From 6980c8006b5a19f31a20e11bf1525c29bd2c196c Mon Sep 17 00:00:00 2001 From: "cmzmasek@gmail.com" Date: Wed, 9 Feb 2011 01:21:22 +0000 Subject: [PATCH] initial commit --- forester/test_data/T4816.nex | 64 + forester/test_data/basics.nh | 14 + forester/test_data/bcl.aln | 121 + forester/test_data/fasta_0.fasta | 26 + forester/test_data/gene_ontology_edit.obo |301663 ++++++++++++++++++++++ forester/test_data/gene_tree_1.xml | 117 + forester/test_data/gene_tree_2.xml | 117 + forester/test_data/hmmpfam_output | 128 + forester/test_data/hmmpfam_output2 | 612 + forester/test_data/hmmpfam_output3 | 178 + forester/test_data/hmmpfam_output_short | 44 + forester/test_data/hmmscan30b3_output_1 | 2264 + forester/test_data/hmmscan30b3_output_2 | 72 + forester/test_data/midpoint_rooting_neg_bl.nh | 1 + forester/test_data/msa_1.txt | 27 + forester/test_data/msa_2.txt | 13 + forester/test_data/msa_3.txt | 33 + forester/test_data/ncbi.fasta | 101 + forester/test_data/nexus_test_1.nex | 5 + forester/test_data/nexus_test_2.nex | 9 + forester/test_data/nexus_test_3.nex | 4 + forester/test_data/nexus_test_4.nex | 89 + forester/test_data/nexus_test_5.nex | 9 + forester/test_data/nexus_test_6.nex | 16 + forester/test_data/nexus_test_7.nex | 54 + forester/test_data/nexus_test_8.nex | 29 + forester/test_data/nexus_test_9.nex | 33 + forester/test_data/obo_test | 293 + forester/test_data/paup_log_test_1 | 119 + forester/test_data/pfam_to_go_test | 434 + forester/test_data/phylogeny27.nhx | 1 + forester/test_data/phylogeny28.nhx | 51 + forester/test_data/phyloxml_distribution.xml | 102 + forester/test_data/phyloxml_test_atv.xml | 142 + forester/test_data/phyloxml_test_t1.xml | 210 + forester/test_data/phyloxml_test_t2.xml | 48 + forester/test_data/phyloxml_test_t3.xml | 54 + forester/test_data/phyloxml_test_t4.xml | 50 + forester/test_data/quotes.nhx | 12 + forester/test_data/special_characters.xml | 31 + forester/test_data/species_tree_1.xml | 117 + forester/test_data/species_tree_1_unresolved.xml | 107 + forester/test_data/tol_16299.tol | 259 + forester/test_data/tol_2.tol | 6156 + forester/test_data/tol_2484.tol | 75 + forester/test_data/tol_4567.tol | 12 + forester/test_data/tol_5.tol | 1846 + 47 files changed, 315962 insertions(+) create mode 100644 forester/test_data/T4816.nex create mode 100644 forester/test_data/basics.nh create mode 100644 forester/test_data/bcl.aln create mode 100644 forester/test_data/fasta_0.fasta create mode 100644 forester/test_data/gene_ontology_edit.obo create mode 100644 forester/test_data/gene_tree_1.xml create mode 100644 forester/test_data/gene_tree_2.xml create mode 100644 forester/test_data/hmmpfam_output create mode 100644 forester/test_data/hmmpfam_output2 create mode 100644 forester/test_data/hmmpfam_output3 create mode 100644 forester/test_data/hmmpfam_output_short create mode 100644 forester/test_data/hmmscan30b3_output_1 create mode 100644 forester/test_data/hmmscan30b3_output_2 create mode 100644 forester/test_data/midpoint_rooting_neg_bl.nh create mode 100644 forester/test_data/msa_1.txt create mode 100644 forester/test_data/msa_2.txt create mode 100644 forester/test_data/msa_3.txt create mode 100644 forester/test_data/ncbi.fasta create mode 100644 forester/test_data/nexus_test_1.nex create mode 100644 forester/test_data/nexus_test_2.nex create mode 100644 forester/test_data/nexus_test_3.nex create mode 100644 forester/test_data/nexus_test_4.nex create mode 100644 forester/test_data/nexus_test_5.nex create mode 100644 forester/test_data/nexus_test_6.nex create mode 100644 forester/test_data/nexus_test_7.nex create mode 100644 forester/test_data/nexus_test_8.nex create mode 100644 forester/test_data/nexus_test_9.nex create mode 100644 forester/test_data/obo_test create mode 100644 forester/test_data/paup_log_test_1 create mode 100644 forester/test_data/pfam_to_go_test create mode 100644 forester/test_data/phylogeny27.nhx create mode 100644 forester/test_data/phylogeny28.nhx create mode 100644 forester/test_data/phyloxml_distribution.xml create mode 100644 forester/test_data/phyloxml_test_atv.xml create mode 100644 forester/test_data/phyloxml_test_t1.xml create mode 100644 forester/test_data/phyloxml_test_t2.xml create mode 100644 forester/test_data/phyloxml_test_t3.xml create mode 100644 forester/test_data/phyloxml_test_t4.xml create mode 100644 forester/test_data/quotes.nhx create mode 100644 forester/test_data/special_characters.xml create mode 100644 forester/test_data/species_tree_1.xml create mode 100644 forester/test_data/species_tree_1_unresolved.xml create mode 100644 forester/test_data/tol_16299.tol create mode 100644 forester/test_data/tol_2.tol create mode 100644 forester/test_data/tol_2484.tol create mode 100644 forester/test_data/tol_4567.tol create mode 100644 forester/test_data/tol_5.tol diff --git a/forester/test_data/T4816.nex b/forester/test_data/T4816.nex new file mode 100644 index 0000000..839de21 --- /dev/null +++ b/forester/test_data/T4816.nex @@ -0,0 +1,64 @@ +#NEXUS + +[!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. + + +Downloaded on March 30, 2010; 21:54 GMT + +TreeBASE (cc) 1994-2008 + +Study reference: +Maddison W., Zhang J., & Bodner M. 2007. A basal phylogenetic placement for the salticid +spider Eupoa, with descriptions of two new species (Araneae: Salticidae). +Zootaxa, 1432: 23-33. + +Study ID = 1787] + +BEGIN TAXA; + TITLE Combined; + DIMENSIONS NTAX=33; + TAXLABELS + Zenodorus_cf._orbiculatus + Tomocyrba_andasibe + Thrandina_paroculus + Xysticus_sp. + Terralonus_mylothrus + Spartaeus_uplandicus + Spartaeus_spinimanus + Sitticus_palustris + Salticus_scenicus + Portia_labiata + Portia_cf._schultzi + Phaeacius_cf._fimbriatus + Pellenes_peninsularis + Orthrus_bicolor + Naphrys_pulex + Cheiracanthium + Massagris_schisma + Massagris_cf._honesta + Lyssomanes_viridis + Holcolaetis_sp. + Hispo_cf._frenata + Helvetia_sp. + Heliophanus_cupreus + Goleba_lyra + Cesonia_sp. + Ghelna_canadensis + Galianora_sacha + Galianora_bryicola + Evarcha_proszynskii + Eupoa_nezha + Euophrys_monadnock + Dendryphantes_hastatus + Hibana_sp. + ; +END; + +BEGIN TREES; + TITLE Tb8353; + LINK TAXA = Combined; + TREE Fig._15 = [&R] (Hibana_sp.,(((((((((Dendryphantes_hastatus,(Ghelna_canadensis,Terralonus_mylothrus)),(Euophrys_monadnock,(Naphrys_pulex,Zenodorus_cf._orbiculatus)),(Evarcha_proszynskii,Pellenes_peninsularis)),Salticus_scenicus),(Heliophanus_cupreus,(Helvetia_sp.,Orthrus_bicolor))),Sitticus_palustris),(Hispo_cf._frenata,((Massagris_cf._honesta,Massagris_schisma),Tomocyrba_andasibe))),(Eupoa_nezha,(((Galianora_bryicola,Galianora_sacha),Thrandina_paroculus),((Holcolaetis_sp.,(Portia_cf._schultzi,Portia_labiata)),(Phaeacius_cf._fimbriatus,Spartaeus_spinimanus),Spartaeus_uplandicus)),(Goleba_lyra,Lyssomanes_viridis))),Cheiracanthium),Xysticus_sp.),Cesonia_sp.); +[! TreeBASE tree Id = 4816 ] + + +END; diff --git a/forester/test_data/basics.nh b/forester/test_data/basics.nh new file mode 100644 index 0000000..b8d8171 --- /dev/null +++ b/forester/test_data/basics.nh @@ -0,0 +1,14 @@ +(a); +(a,b); +(a,b,c); +((a)b); +((((a,b),c),d),e); +(((a,b),c),d); +((a,b),c); +((a,b,c,d),(e,e,f,g,h,i,j,k)); +((a,b),(c,d,e,f,g,h,i,j,k,l,m,n,o,p,q,r,s,t,u,v,w,x,y,z)); +((a,b),(c,d,e,f,g,h,i,j,k,l,m,n,(1,2,3,4,5,6,7,8,9,10,11,12),o,p,q,r,s,t,u,v,w,x,y,z)); +((a,b),(c,d,e)); +((a,b),c,d); +((a,b),(c,d)); +((((((a,b),c),d),e),f),(g,h)); \ No newline at end of file diff --git a/forester/test_data/bcl.aln b/forester/test_data/bcl.aln new file mode 100644 index 0000000..33d4c8d --- /dev/null +++ b/forester/test_data/bcl.aln @@ -0,0 +1,121 @@ +120 99 +21_MOUSE LREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGW +1_HUMAN LREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGW +35_CANFA LREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGW +26_MOUSE LRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGW +66_XENLA MRAAGDEFEERFRQAFSEISTQIHVTPGTAYARFAEVAGSLFQGGVNWGRIVAFFVFGAALCAESVNKEMSPLLPRIQDWMVTYLETNLRDWIQSNGGW +54_CHICK LRDAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFHDGVNWGRIVAFFSFGGALCVESVDKEMRVLVGRIVSWMTTYLTDHLDPWIQENGGW +0_HUMAN LRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGW +29_MOUSE MRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQDWMVAYLETRLADWIHSSGGW +12_HUMAN MRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETRLADWIHSSGGW +44_CANFA MRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETRLADWIHSSGGW +46_CHICK LRQAGDEFSRRYQRDFAQMSGQLHLTPFTAHGRFVAVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIATWMTEYLNRHLHNWIQDNGGW +64_XENLA LLDASEEFELRYQRAFSDLTAQLHLTQDTAQQSFQQVVGELFRDGTNWGRIVAFFSFGRALCVESANKEMTELLPRIVQWMVQYLEHTLQPWMLENGGW +79_BRARE LRDSANEFELRYSRAFNDLSSQLHITPATAYQSFESVMDEVFRDGVNWGRIVGLFAFGGALCVECVEKEMSPLVGRIAEWMTVYLDNHIQPWIQSQGGW +86_FUGRU LRDTGNEFELRYTCAFSDLHNQLHITPATAYQSFENVMDEVFRDGVNWGRIVGLFAFGGALCVECVEKEMSPLVGRIIEWMTVYLDNHIQPWIQSQGGW +108_TETNG LRDTGNEFELRYTCAFSDLHNQLHITPATAYQSFENVMDEVFRDGVNWGRIVGLFAFGGALCVECVEKEMNPLVGRIIEWMTVYLDNHIQPWIQSQGGW +10_HUMAN LAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMHHCIARWIAQRGGW +9_HUMAN LAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMHHCIARWIAQRGGW +3_HUMAN LRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGW +32_CANFA LAIIGDDINQRYDSEFQAMLQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFGYRLALHVYQRGLTGFLGQVTRFVADFMHHCIARWIAQRGGW +4_HUMAN LQNVAFSVQKEVEKNLKSCLDNVNVVSDTARTLFNQVMEKEFEDGINWGRIVTIFAFEGILIKKLLRQQIAPDYKEISYFVAEFIMNNTGEWIRQNGGW +67_XENLA LSRAGDEFSRLYQQDFRQISGLLHLTPSTVRVRFATVVEELFHDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDSIVGWMTEYLNSHLQNWIQEQGGW +30_MOUSE LQRVAFSVQKEVEKNLKSYLDDFHVESDTARIIFNQVMEKEFEDGINWGRIVTIFAFGGVLLKKLPQEQIALDYKQVSSFVAEFIINNTGEWIRRNGGW +135_CAEBR MRSLGTIFEKRHMEMFENFSEQLLAVPKISFSLYQEVVQTVGNCPMSYGRLIGLISFGGMVAAKMMESELQGQVRNLLMYTSLFIKTRIQSWKEHNRSW +90_FUGRU LRDSAEEFEKLFAQAFSDLSSQLDITPDTAYQSFKNVMDEVFKDGVNWGRVVGLFAFGGVLCVECVEKDASQLVCRIADWMTIYLDEHINPWIQSQGGW +82_BRARE LRDAGDEIERIYQREFEEMSQQMVFNPNSAQRSFLTVAEELFRDGVNWGRIIAFFEFGGTMCVESVNREMASQVDNIAHWMTDYLNGPLENWIEENGGW +101_TETNG LRDSAEEFEKLFAQAFSDLSSQLVITPDTAYQSFKNVMDEVFKDGVNWGRIVGLFAFGGVLCVECVEKDASELVCRIADWMTIYLDEHINPWIQSQGGW +27_MOUSE LRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGW +33_CANFA LRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVIVHVFSDGTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGW +104_TETNG LREAGDELERLYQPDFTEMSRQLYLTSTTAQRRFAEVIDELFRDGVNWGRIIAFFEFGAAVCAECAAKEMSPQVDNIAEWMTEYLSGSLNSWIQDNGGW +20_MOUSE LRRIGDELDSNME--LQRMIADVDT--DSPREVFFRVAADMFADGFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGW +5_HUMAN LKRIGDELDSNME--LQRMIAAVDT--DSPREVFFRVAADMFSDGFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGW +6_HUMAN LKRIGDELDSNME--LQRMIAAVDT--DSPREVFFRVAADMFSDGFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGW +18_MOUSE LLRLGDELEQIRPSVYRNVARQLHIPLPVVTDAFLAVAGHIFSAGITWGKVVSLYSVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGW +55_CHICK LAIIGDDINKRYDAEFRHMLKSLQPTKENAYEYFTTIASSLFDSGINWGRVIALLGFGYCMAIHVYQQGITGFLRRIARYVTEFMRNRIARWIAQQGGW +118_BRAFL LAMIGDEIETRYESEFKAMIKTLRVTPSTAYEAFAGVARRLFRDGINWGRIVALLCFGYRMAVDVLERGIPDFVRQIIKYVVKFISERIARWIAEHGGW +119_BRAFL LAMIGDEIETRYESEFKAMIKTLRVTPSTAYEAFAGVARRLFRDGINWGRIVALLCFGYRMAVDVLERGIPDFVRQIIKYVVKFISERIARWIAEHGGW +11_HUMAN LLRLGDELEMIRPSVYRNVARQLHISLPVVTDAFLAVAGHIFSAGITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGW +45_CANFA ------------------MSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGW +116_BRAFL MRELGDKFEERYREQFDEMGDQLHLTPDTAYQKYHNVVAELFREGVRWGRLVALVAFTGACTVTAVEREMPQFVDRYVDWTVQYIDNNLAQWLQENGGW +39_CANFA LQDVAFSVQGQVEKNLKPCLDSFDVVSDTARTIFNQVMEKEFEDGINWGRIVTVFAFEGILTKKLLEQRISSDAEKVSYFVAEFITRNMRDWIRQNGGW +68_XENLA LRKIGDELDANIE--LQRRIECVPC--NSPKQVFFHVAKELFADGFNWGRVVALFYFACKLVVKALCTKVPEMIRTIINWTMEYLREYVVQWIRDQGGW +137_NEMVE LRSLASHMEAEYPDLFETACTKLGITPATARSTFFSVAKEIFQTGINWGRIVALFTFGGVVAHHFIESERPEMVPHVVEWIPSFIADNLLSWIMENGGW +140_NEMVE LRIVADELIADNSELFHSMCDQLHLTPISTYPTFVGIANEIFQSGKNWGRVVAFLAFGATLAVYCAQRELHELVNDIVEWVSRYMDQNLSCWIRENGGW +110_TETNG LQKIGDELDSNME--LQRMIDDSAL--KPTKDMFMKVAFEIFSDGFNWGRVVALFYFACRLVIKALVTHVPDIIRTIISWTMDYLQEHVANWIREQGGW +134_CAEEL MRVMGTIFEKKHAENFETFCEQLLAVPRISFSLYQDVVRTVGNCPMSYGRLIGLISFGGFVAAKMMESELQGQVRNLFVYTSLFIKTRINNWKEHNRSW +143_NEMVE LGEVGDEIDAKYRDQFHDMIESLHLTPGTAYDTFAAVARRLFRSGISWGRIIALLCFGYEIAITVIRRGFSSFLRRIIRFVVDFIRERIARWIAEHGGW +53_CHICK ----GDELEYIRPNVYRNIARQLNISLTVVTDAFLAVAAQIFTAGITWGKVVSLYAVAAGLAVDCVRHAQPAMVHTIVDCLGEFVRKTLVTWLKRRGGW +65_XENLA FLRLGDELEYMRPTVYRNIARQLNISLTILSDAFLAVAAEIFTAGITWGKVVSLYAVAAGLAVDCVKQSQPALVLTIVDCLGEFIRKTLVTWLKRRGGW +8_HUMAN MKTGALLLQ--------GMIAAVDT--DSPREVFFRVAADMFSDGFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGW +72_BRAREa LQQIGDELDGNAQ--LQSMLNNSNL--QPTQDVFIRVAREIFSDGFNWGRVVALFYFACRLVIKAISTRVPDIIRTIISWTMSYIQEHVINWIREQGGW +141_NEMVE LRKLADKIEEQYPALLNHLCHKLNISRSTAYSTFVEIAGEVFADGVNWGRIVVLYAFGGRLAVYCEQHNMKDLVQSVTDWVGKYIAG-LSEWIANEGGW +139_NEMVE LREIGDQLTND--ATLNNLIAECHVTKDTAFDTFLAVALQIFQDGINWGRIVTLFYFGYKLALKVLNQ--IPLIKMIIEWVVKFVKEKLVKWIFQQGGW +100_TETNG LRKATDDFEKKLTRACGDLSSYLPSK--ISHQNFNNTMDQIFEGNVHWGVVIGLFVVGGAMCVQCVRNNHEELVCHIADWMTAYLDEHLEPWIQRQGGW +50_CHICK LRNIASSLQDQTEEALRPFLDRIDITSDVAKRIFNGVMEEKFADGTNWGRIMTIFTFGGLLTKKLQEHGVQLTKEKISYFITEYIINNKAAWIDANGGW +114_BRAFL LQRTADELLERHQYFFNGMVNRLQISPETSYTTFKNVADEMLKDQVNWGRVVALYAFAGRIAVHCREQN-PEVAETVGEFLGKYVGSNLEGWIKENGGW +117_BRAFL LQRTADELLERHQYFFNGMVNRLQISPETSYTTFKNVADEMLKDQVNWGRVVALYAFAGRIAVHCREQN-PEVAETVGEFLGKYVGSNLEGWIKENGGW +122_SPHGR IVNLSEKLMNDYRDSFSDMPNQLKITENTISSTFKAVTSELFVDGISWGRIVAFFSFGGALCEWCQEKDIPRAFPTVEELMVAYINSHLITWIHANGGW +120_CIOIN LRRIGDDMSRDIQ--LNRFIDQVPL--KSTKDIFIKVCLQMFEDGFNWGRIVALFYFAYRLIVRSLLSGLDPWIRELISWVVDFIVKKFAKWIISRGGW +106_TETNG --ASGDELEHLRPNVYCNVARQLNITVSIMSDAFLAVAADIFSTGVTWGKVVSLYAVAGALAVDCVRHGHPAMVHTIVDCMGEFVRKSLTSWLKRRGGW +142_NEMVE LRKLSNQIENKHELFLRNMCDRLDIRQHNAPETFKQVADEIFGDGINWGRIVVLYTFAGKVAKYCQENQ-LDNAENVATWVGNYVAS-KSDWVKKAGGW +126_SPHGR LAQIGDQIDAQYEGEFRQMIQMLHITPSTAYQAFAGVARRLFIKGINWGRISALLMFGYRIARDVMTS-VGDFFHKIVGDLVRFISERIATWIAQQGGW +76_BRARE LLKLGDELECMRPYVYRNIAKQLNISVAVVSDAFLSVATEVIAMGITWGKVVAIYAVAAGLAVDCVRLGHPVMVHTIVDSLGEFVRRSLVPWLKKRGGW +77_BRARE LLKLGDELECMRPYVYRNIAKQLNISVAVVSDAFLSVATEVIAMGITWGKVVAIYAVAAGLAVDCVRLGHPVMVHTIVDSLGEFVRRSLVPWLKKRGGW +73_BRARE MRYLAKEMEQQHRTKFRSLSQEFLDTCADPSKCLQSVMRELVGDGMNWGRVVSIFTFTGVLASELLSRGENSESRRLAETIADYLGGEKQDWLVENGGW +147_HYDAT MMRLVEEIEIKHELFLSNMCKRLNLNTENAQSMFHTIAEEIFSDGINWGRIIVLYAFAGKIAEHCRKSNDEQIIDKIALWVAGFVAK-KSSWIRDSGGW +121_SPHGR LRRVGDEVEERYAITLNGLVNNLEYDPKDGEEAFTASLNAMFEEGCNWGRVVMVYVFAARLAKYCQENGKGYHVGSLADFAGRYVASRLTPWINKQGGW +105_TETNG LLCLGDELESMQPSLYRNVARQLNISVNMVSDAFIAVATEILSTGITWGKVVSMYAVAGALAVDCVRQGHPTTVHILVDSLGQFVRRFLVPWLKRRGGW +47_CHICK LVLGRGLLKQLLYHQTPGMLRKLEIKKEDDLQAVCEVAAHVFNDGTNWGRVVTLISFGAFVAKHLKSINQEKCITSLAGIITDALVSSKREWLMSQGGW +93_FUGRU MKRVVANLMEKHRYVYNGMTKQLTLDDRGDDVSFSSVAKSIFADGTNWGRIASLVAFGAVVAQHMKDNGRRDCVEPVAQEISTYLLTDRRDWLIKNNGW +87_FUGRU LLCLGDELESMQPSLYRNVARQLNISVNMVSDAFIGVATEILSTGITWGKVVSMYAVAGALAVDCVRQGHATTVHILVDSLGQFVRKFLVPWLKRRGGW +115_BRAFL LQRTANELLERHQYFFTGMFNRLQISPETSYTTFKNVADEMLKDQVNWGRVVALYAFAGRIAFHFREQN-PEGAETFGEFLGKYVGGNLEGWIKENGGW +94_FUGRU LRSMANKYERDFMEQAGDLSPYVAVT--RNKAGFNKVMDDMFRDKINWGTVVGLFVVGGATYVQSFEGGASEPVCHVADWMTDYLDQRINPWIESQGGW +146_SUBDO IERIVCQLEDERSQQFIDILRGLEIDQQNLRITYQTIVGEIFNDGVHWGRIVAFLVFSGHLAVHCARSGLENRVRDVVEWTEAEMRLRVHQWVEDRGGW +113_BRAFL LFLMGGELERMYPHLYRDVSRQINITLSILETSFETVANELFSTGITWARVVAMFAVAGAFSVDCVHQGHPMFTRRLVDIVVDFTDRKLSSWLVQEGGW +125_SPHGR LTLVGSELERMYPTLYKDITKQLNVTIQILEQVLFDVGDAVFKAGITWARVVAFFVVSSSLSVECMQQGNGIFVHSITVALTRYVQTKLVKWITQRGGW +97_FUGRU LWSMANKFEQDFIQLAGDLSSYGAMT--RNQASFNKVMDDMFSDEINWGTVVGLFVVGGAICGQSVEGDASEPVCHIADWMAAYLDKRINPWIESQGGW +88_FUGRU LREAGDELERLYQPDFTEMSRQLYLSSTTAQRRFAEVIDELFRDGVNWGRIIAFFEFGGAVCAECAAKEMSPQVDNIA--------------------E +80_BRARE MKRVVDNILVKHQIAYKGMIQRLQLDSQPASLDFRCIASTMFKDGTNWGRIASLVAFGAVVCSRLKELQQDQCVERVAEQISSYLTSEQQDWILKNKSW +98_FUGRU LRSMANKFEQDFIQLAGDLSSYGAVT--RNQASFNKLMDNMFSDEINWGTIVGLFVVGCAICVQSVEGSASQPVCHIADWMTVYLDKRINPWIENQGGW +127_SPHGR LIKVATEFEKCFPYLYEDITEQLQLNFANILSVYNTVGADIFRKGITWARIVALYTLTGALIVECVKQGQHSQANALVDALQKLVRKRLARWIIDQGGW +72_BRAREb MVRIANEMEGNEE--LQGMLNSALL--NPTLEHYILVVNGTFSDVLSWGSVVALFYVACRFVVKAAEINSVDLVRSIINWTMPFIRKCILTWIREQGGW +89_FUGRU RPT----------KVFDAELP-LM-GSQSSVESFNKVMDDMFKDEINWGTVVGLFVVGGAICVQSVECGASEPVCHIADWMTAYLDKQINPWIESQGGW +138_NEMVE -QEVGWMLEECYPRLYADISRHVNASFTVVHDVFSSVCTEIVKDGVNWARIIAVYTFAGALATECYKDSRSVFVTEVSNWMYEFTALHLVDWIKKRGGW +99_FUGRU LRSMANKYERDFMEQAGDLSPYVAVT--RNKAGFNKVMDDMFRDEINWGTVVGLFVVGGATYVQSFEGGASEPVCHVADWMTDYLDQRINPWIESQGGC +59_XENLA TRAVVA---QCSRGRPFSIAS---LAHREDLQKLSEVPALVFNDGVNWGRIVTVISFGAFVAKHLKSIDLEDCIMALAEHFTLFLMTSKKDWIIQEKGW +129_DROME LNSMGEELERMHPRVYTNISRQLSRAPDMAPMLLNLVAKDLFRSSITWGKIISIFAVCGGFAIDCVRQGHFDYLQCLIDGLAEIIEDDLVYWLIDNGGW +95_FUGRU MRHLGQDMEKQHQARFNSLAQTFLRQCPDLCSSLRKVMEELVGDGLNWGRVVSLFTFTGVLARLMQEQKSVPECRGLAETIADYLGEEKKDWLLENGGW +131_DROME VQVLGDELERMHPRIYNGVARQICRNPDAVSLLLGAVGRELFRVEITWSKVISLFAIAGGLSVDCVRQGHPEYLPKLMESVSEVIEDELVPWINENGGW +109_TETNG R--VVGDLMEKHRYTYRGMINKLFMEDRVGDVSFGAVAKSTFEDGTNWGRVASLLAFAAVVAQYLNDHGQRDCVEQVAQEISTYLLTDQRDWLIKNNAW +22_MOUSE LQRVAFSVQKEVEKNLKSYLDDFHVESDTARIIFNQVMEKEFEDGINWGRIVTIFAFGGCSPSKNFHKSR-------------------------LPWM +145_LUBBA TFVCVADITCN-HDEFDQMCLQLDASPTSVQPRVVQIFRETFNDGINWGRIVAFLAFMSHFSADCEKKQLYGSVESICEWSVDLITSHLENWIRAEGGW +92_FUGRU M------------------------T--RNQACFNKVMDDMFRGEINWGTVVGLFVVGGAICVQSVEGDASEPVCHIADWMAAYLDKRINPWIESQGGW +136_NEMVE M-------ENAYPALYQNISEQLNFRIIVVCGMFTCVCDNILASGITWARVVSLYAFAAALAVDCCQTDV-RIAKNISKWMGQYTKKRLSGWVRENGGW +128_SPHGR LIEYCI---HRIRKESIELAS----YQHVSREPYAPVAARMREIGVTWGRIAALIAFSGRLSVHCASNNLEDLVPSIIGWTSRYIGSKLLPWMQDHQNW +85_BRARE MRRVVDNLAVKHELAYKGMIARLNLEQKGEDSFIKQVATELFSDGTNWGRIASLLTFGAMLCKYQNDRGHSKYVSTCCGYLSQRHMVKLH-GIQLKGLW +42_CANFA LKRIGDELDSNME--LQRMIAAVDT--DSPREVFFRVAAEMFSDGFNWGRVVALFYFASKLVLK----------------------------------- +83_BRARE LRHAGDELLIRFPIFFRRWPRVFQVTEHTACPTLLSILDEHFAPTLAWSAVLSVFVLAGQLALHCQDRGMEDITPQIQECVGSYVERVICPEIRDKGGW +103_TETNG LRHAGDELLNRFPIFFRRWPRVFQVTENTACSTLTGILDEHFFPPLAWSAVLSVYVLAGQMALHCNERGMVAVLPQLKECVGAYVEKVICPEIRDKGGW +144_GEOCY GI-V----ERN-VRDFR--RGGWDVTPDNVESEFREVERRTFSDGVHWGRVIAFLAFSMSFAAYVNSRGIDGGAYSVFNWTLRVLNDSLADFIQRENGW +132_DROME LNSMGEELERMHPRVYTNISRQLSRAPDMAPMLLNLVAKDLFRSSITWGKIISIFAVCGGFAIDCVRQGHFDYLQCLIDGLAE---------IIGRPGL +123_SPHGR IAQIGDCIMLHHHDELEQAYQQTL-GHPMNYGVFKSGMKSLVKNSVGWYHVAVMMKFTRRMAVNVLDQGS-RGIAAVTDFAAQYIEENLAQSIIEQGGW +124_SPHGR IAQIGDCIMLHHHDELEQAYQQTL-GHPMNYGVFKSGMKSLVKNSVGWYHVAVMMKFTRRMAVNVLDQGS-RGIAAVTDFAAQYIEENLAQSIIEQGGW +14_HUMAN LRSAAARLRQIHRSFFSAYLGYP-----GNRELVALMADSVLSDPPTWGRVVTLVTFAGTLLERGWEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGW +36_CANFA LKYSGDRLERELKKDKAL-MNS--FQDRLSYPVFKTITDQFLRGVDTRGEEVRARGFKAALAIDVTAKD-NHPMNRVLGFGTKYLKDNFSPWVQQQGGW +40_CANFA LAHLGEKVSQELKEPLQKALQMLL---PVTYQAYRECTLETTVHASGWNKILVPLVLLQQMLLELTRRGQ-EPLSALLQFGVTYLEDYAAEYIIQQGGW +61_XENLA LRQASDELLEKFPIFFKRWPKVFRVTEERACDFLIQIVDENFQQQLPWSTVLSVYVLAGQMAINCQKNGMERALGPLAETVGHYVEENICPLIKEKDGW +15_HUMAN LAHLGEKVSQELKEPLHKALQMLL---PVTYQAFRECTLETTVHASGWNKILVPLVLLRQMLLELTRRGQ-EPLSALLQFGVTYLEDYSAEYIIQQGGW +25_MOUSE LAHLGERVSQDLKEPLQKALQTIL---PVTYEAYRECTVETAVHASGWNKLLVPLVLLQHLLLELTRRGQ-EPLRMLLQFGVMYLEEHAAEFIIQQGGW +13_HUMAN LKYSGDQLERKLKKDKAL-MGH--FQDGLSYSVFKTITDQVLMGVDPRGEEVKAQGFKAALVIDVTAKD-NHPMNRVLGFGTKYLKENFSPWIQQHGGW +2_HUMAN LREAGDEFELRYRRAFSDLTSQLHITPG--------------------------QSFEQDT-FVELYGNNAAAESRKGQERFNRLTGMTVAGVVLLGSL +81_BRARE LKKTGDDLDQKIKEDHAF-FAD--LQKAFSYRFFGKLTKAFISSV-V-PG-DQESWKQIALTFEVTSRD-LQPMNRIMGYGAQYLQEHFAPWIKQKGGW +62_XENLA LSHLCEKLATEIRESLDKASEGLL---SLAAEEFRKAVALISVHATGWNKVLAPLVLLQQLLLELTRRGE-YQLKALVQLGVSYIEDMCADFIIQQGGW +74_BRARE LAVLGDRVSRDLDTHLFSATNTLL---DLNFECFRAAVDEVSSHAGGWSKVLVPLVLLQALQAK-----G-QSLEALLQCGLRYLEESQADFIIQQGGW +84_BRARE LAVLGDRVSRDLDTHLFSATNTLL---DLNFECFRAAVDEVSSHAGGWSKVLVPLVLLQALQAK-----G-QSLEALLQCGLRYLEESQADFIIQQGGW +56_CHICK LRKSGDQLEEKFKKDRSF-YQR--FEDMLSYAFFERLTDLFLENVDSTNEEDQLQCTKVAFTLEVATRD-NHPMNLVMGFGLKYLQEHFSPWIRDRGGW +75_BRARE LKKTGDDLDQKIKEDHAF-FAD--LQKAFSYRFFGKLTQAFISTVVP-GN-QESTCKQIALTFEVTSRD-LQPMNRIMGYGAQYLQEHFAPWIKQKGGW +19_MOUSE LKFSGDQLGREIKKDKAL-MSS--FQDGLSYSTFKTITDLFLRDVDTRGEEVKARGFKAALAIDAIAKD-NHPMNRMLGFGTKYLREYFSPWVQQNGGW +102_TETNG LAAVGDRVAGELHTHLAAALHTLL---PIDYQRFRDVTRGLSTHAGGWKKVLVPLVLLQALQRE-----G-QSLATLLQLGLRFLEEEQAGYILHEGGW +17_HUMAN LRMLGDQFNGELEASAKNVIAETI-KGQT-GAILQDTVES----------------------------------------------------------- +31_MOUSE ------------------------------------------------------------------VIVTRDCCLIVNFLYNLLMRRHRARLEALGGW- diff --git a/forester/test_data/fasta_0.fasta b/forester/test_data/fasta_0.fasta new file mode 100644 index 0000000..a92a610 --- /dev/null +++ b/forester/test_data/fasta_0.fasta @@ -0,0 +1,26 @@ + +23 33 + + > one dumb + + ACGT Gk,fmfdm[e,,,sfmfmf + + +>two dumb + dk,asdf;sf; fkfks;dfksl; +>three dumb +s;dfks;lfsfpwe[prow[err +>four dumb + + AAAAAAAAAA + +AAAAAAA AAA +A +A +A + +>five dumb +ddddddddd + ddddddd dd + + dda>f \ No newline at end of file diff --git a/forester/test_data/gene_ontology_edit.obo b/forester/test_data/gene_ontology_edit.obo new file mode 100644 index 0000000..2e697a0 --- /dev/null +++ b/forester/test_data/gene_ontology_edit.obo @@ -0,0 +1,301663 @@ +format-version: 1.2 +date: 24:11:2008 09:42 +saved-by: tanyaberardini +auto-generated-by: OBO-Edit 1.101 +subsetdef: goslim_candida "Candida GO slim" +subsetdef: goslim_generic "Generic GO slim" +subsetdef: goslim_goa "GOA and proteome slim" +subsetdef: goslim_pir "PIR GO slim" +subsetdef: goslim_plant "Plant GO slim" +subsetdef: goslim_yeast "Yeast GO slim" +subsetdef: gosubset_prok "Prokaryotic GO subset" +synonymtypedef: systematic_synonym "Systematic synonym" EXACT +default-namespace: gene_ontology +remark: cvs version: $Revision: 1.1 $ + +[Term] +id: GO:0000001 +name: mitochondrion inheritance +namespace: biological_process +def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] +synonym: "mitochondrial inheritance" EXACT [] +is_a: GO:0048308 ! organelle inheritance +is_a: GO:0048311 ! mitochondrion distribution + +[Term] +id: GO:0000002 +name: mitochondrial genome maintenance +namespace: biological_process +def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0000003 +name: reproduction +namespace: biological_process +alt_id: GO:0019952 +alt_id: GO:0050876 +def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "reproductive physiological process" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0000005 +name: ribosomal chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] +comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. +is_obsolete: true +consider: GO:0042254 +consider: GO:0051082 + +[Term] +id: GO:0000006 +name: high affinity zinc uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0000007 +name: low-affinity zinc ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0000008 +name: thioredoxin +namespace: molecular_function +alt_id: GO:0000013 +def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] +comment: This term was made obsolete because it represents gene products. +is_obsolete: true +consider: GO:0006467 +consider: GO:0015036 + +[Term] +id: GO:0000009 +name: alpha-1,6-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248] +xref: EC:2.4.1.- +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000010 +name: trans-hexaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30] +subset: gosubset_prok +synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] +synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30] +synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30] +synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30] +synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] +xref: EC:2.5.1.30 +xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0000011 +name: vacuole inheritance +namespace: biological_process +def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] +is_a: GO:0007033 ! vacuole organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0000012 +name: single strand break repair +namespace: biological_process +def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0000014 +name: single-stranded DNA specific endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0000015 +name: phosphopyruvate hydratase complex +namespace: cellular_component +def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "enolase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0000016 +name: lactase activity +namespace: molecular_function +def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] +synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] +synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] +xref: EC:3.2.1.108 +xref: MetaCyc:LACTASE-RXN +xref: Reactome:20536 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0000017 +name: alpha-glucoside transport +namespace: biological_process +def: "The directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042946 ! glucoside transport + +[Term] +id: GO:0000018 +name: regulation of DNA recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006310 ! DNA recombination + +[Term] +id: GO:0000019 +name: regulation of mitotic recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] +synonym: "regulation of recombination within rDNA repeats" NARROW [] +is_a: GO:0000018 ! regulation of DNA recombination +relationship: regulates GO:0006312 ! mitotic recombination + +[Term] +id: GO:0000020 +name: negative regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it describes a substrate-specific process. +is_obsolete: true +consider: GO:0045950 + +[Term] +id: GO:0000022 +name: mitotic spindle elongation +namespace: biological_process +def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] +synonym: "spindle elongation during mitosis" EXACT [] +is_a: GO:0051231 ! spindle elongation +relationship: part_of GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0000023 +name: maltose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malt sugar metabolic process" EXACT [] +synonym: "malt sugar metabolism" EXACT [] +synonym: "maltose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0000024 +name: maltose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malt sugar biosynthesis" EXACT [] +synonym: "malt sugar biosynthetic process" EXACT [] +synonym: "maltose anabolism" EXACT [] +synonym: "maltose biosynthesis" EXACT [] +synonym: "maltose formation" EXACT [] +synonym: "maltose synthesis" EXACT [] +is_a: GO:0000023 ! maltose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0000025 +name: maltose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malt sugar catabolic process" EXACT [] +synonym: "malt sugar catabolism" EXACT [] +synonym: "maltose breakdown" EXACT [] +synonym: "maltose degradation" EXACT [] +synonym: "maltose hydrolysis" NARROW [] +xref: MetaCyc:MALTOSECAT-PWY +is_a: GO:0000023 ! maltose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0000026 +name: alpha-1,2-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541] +xref: EC:2.4.1.- +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000027 +name: ribosomal large subunit assembly and maintenance +namespace: biological_process +def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form and maintain the large ribosomal subunit." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042257 ! ribosomal subunit assembly +relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis + +[Term] +id: GO:0000028 +name: ribosomal small subunit assembly and maintenance +namespace: biological_process +def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form and maintain the small ribosomal subunit." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042257 ! ribosomal subunit assembly +relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis + +[Term] +id: GO:0000030 +name: mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +subset: gosubset_prok +xref: EC:2.4.1.- +xref: Reactome:7672 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0000031 +name: mannosylphosphate transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0000032 +name: cell wall mannoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [GOC:ai] +subset: gosubset_prok +synonym: "cell wall mannoprotein anabolism" EXACT [] +synonym: "cell wall mannoprotein biosynthesis" EXACT [] +synonym: "cell wall mannoprotein formation" EXACT [] +synonym: "cell wall mannoprotein synthesis" EXACT [] +is_a: GO:0006057 ! mannoprotein biosynthetic process +is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process + +[Term] +id: GO:0000033 +name: alpha-1,3-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:mcc, PMID:10521541] +xref: EC:2.4.1.- +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000034 +name: adenine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] +subset: gosubset_prok +synonym: "ADase activity" EXACT [EC:3.5.4.2] +synonym: "adenase activity" EXACT [EC:3.5.4.2] +synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] +synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] +xref: EC:3.5.4.2 +xref: MetaCyc:ADENINE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0000035 +name: acyl binding +namespace: molecular_function +def: "Interacting selectively with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "acyl-CoA or acyl binding" BROAD [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0000036 +name: acyl carrier activity +namespace: molecular_function +def: "Enables the directed movement of acyl groups into, out of, within or between cells." [ChEBI:22221, GOC:cb] +subset: gosubset_prok +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0000038 +name: very-long-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater." [GOC:hjd] +subset: gosubset_prok +synonym: "very-long-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0000039 +name: plasma membrane long-chain fatty acid transporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product and it contains component information. +is_obsolete: true +consider: GO:0005324 +consider: GO:0005886 + +[Term] +id: GO:0000040 +name: low-affinity iron ion transport +namespace: biological_process +def: "The directed, low-affinity movement of iron (Fe) ions into, out of, within or between cells. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] +synonym: "low affinity iron ion transport" EXACT [] +is_a: GO:0034755 ! transmembrane iron ion transport + +[Term] +id: GO:0000041 +name: transition metal ion transport +namespace: biological_process +def: "The directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "transition metal transport" EXACT [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0000042 +name: protein targeting to Golgi +namespace: biological_process +def: "The process of directing proteins towards the Golgi using signals contained within the protein." [GOC:ai] +synonym: "protein-Golgi targeting" EXACT [] +is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi +is_a: GO:0006605 ! protein targeting + +[Term] +id: GO:0000044 +name: ascorbate stabilization +namespace: biological_process +def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] +comment: This term was made obsolete because it is defined as a function term and is in the process ontology. +synonym: "vitamin C stabilization" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000045 +name: autophagic vacuole formation +namespace: biological_process +def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464] +synonym: "autophagosome biosynthesis" EXACT [] +synonym: "autophagosome formation" EXACT [] +synonym: "PAS formation" NARROW [] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0000046 +name: autophagic vacuole fusion +namespace: biological_process +def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole." [PMID:11099404] +synonym: "fusion of autophagosome with lysosome" NARROW [] +is_a: GO:0006944 ! membrane fusion +is_a: GO:0048284 ! organelle fusion +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0000047 +name: Rieske iron-sulfur protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "Rieske iron-sulphur protein" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0000048 +name: peptidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] +synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] +xref: EC:2.3.2.12 +xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN +xref: Reactome:20610 +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0000049 +name: tRNA binding +namespace: molecular_function +def: "Interacting selectively with transfer RNA." [GOC:ai] +subset: gosubset_prok +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0000050 +name: urea cycle +namespace: biological_process +alt_id: GO:0006594 +alt_id: GO:0006871 +def: "A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ornithine cycle" EXACT [] +synonym: "urea biosynthesis" EXACT [] +synonym: "urea biosynthetic process" EXACT [] +xref: Reactome:211547 +xref: Reactome:221324 +xref: Reactome:229964 +xref: Reactome:237981 +xref: Reactome:244600 +xref: Reactome:249543 +xref: Reactome:252354 +xref: Reactome:255509 +xref: Reactome:258881 +xref: Reactome:262258 +xref: Reactome:265108 +xref: Reactome:268232 +xref: Reactome:273914 +xref: Reactome:280393 +xref: Reactome:282778 +xref: Reactome:286409 +xref: Reactome:288203 +xref: Reactome:289764 +xref: Reactome:290323 +xref: Reactome:291648 +xref: Reactome:292335 +xref: Reactome:293622 +xref: Reactome:70635 +is_a: GO:0019627 ! urea metabolic process + +[Term] +id: GO:0000051 +name: urea cycle intermediate metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. +subset: gosubset_prok +synonym: "urea cycle intermediate metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000052 +name: citrulline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "citrulline metabolism" EXACT [] +is_a: GO:0019794 ! nonprotein amino acid metabolic process + +[Term] +id: GO:0000053 +name: argininosuccinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "argininosuccinate metabolism" EXACT [] +is_a: GO:0019794 ! nonprotein amino acid metabolic process + +[Term] +id: GO:0000054 +name: ribosome export from nucleus +namespace: biological_process +def: "The directed movement of a ribosome from the nucleus into the cytoplasm." [GOC:ai] +synonym: "ribosome export from cell nucleus" EXACT [] +synonym: "ribosome export out of nucleus" EXACT [] +synonym: "ribosome transport from nucleus to cytoplasm" EXACT [] +synonym: "ribosome-nucleus export" EXACT [] +is_a: GO:0033753 ! establishment of ribosome localization +is_a: GO:0051168 ! nuclear export +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0000055 +name: ribosomal large subunit export from nucleus +namespace: biological_process +alt_id: GO:0000057 +def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] +synonym: "ribosomal large subunit export from cell nucleus" EXACT [] +synonym: "ribosomal large subunit export out of nucleus" EXACT [] +synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] +synonym: "ribosomal large subunit-nucleus export" EXACT [] +is_a: GO:0000054 ! ribosome export from nucleus + +[Term] +id: GO:0000056 +name: ribosomal small subunit export from nucleus +namespace: biological_process +alt_id: GO:0000058 +def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] +synonym: "ribosomal small subunit export from cell nucleus" EXACT [] +synonym: "ribosomal small subunit export out of nucleus" EXACT [] +synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] +synonym: "ribosomal small subunit-nucleus export" EXACT [] +is_a: GO:0000054 ! ribosome export from nucleus + +[Term] +id: GO:0000059 +name: protein import into nucleus, docking +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins." [GOC:isa_complete, PMID:7878057] +synonym: "protein docking during protein import into nucleus" EXACT [] +synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] +synonym: "protein docking during protein-nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] +synonym: "protein-nucleus import, docking" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0000060 +name: protein import into nucleus, translocation +namespace: biological_process +def: "The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope." [GOC:jl, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "protein import into cell nucleus, translocation" EXACT [] +synonym: "protein translocation during protein import into nucleus" EXACT [] +synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] +synonym: "protein translocation during protein-nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] +synonym: "protein-nucleus import, translocation" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +relationship: part_of GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0000061 +name: protein import into nucleus, substrate release +namespace: biological_process +def: "The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins." [PMID:9687515] +synonym: "protein import into cell nucleus, substrate release" EXACT [] +synonym: "protein substrate release during protein import into nucleus" EXACT [] +synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] +synonym: "protein substrate release during protein-nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] +synonym: "protein-nucleus import, substrate release" EXACT [] +is_a: GO:0043624 ! cellular protein complex disassembly +relationship: part_of GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0000062 +name: acyl-CoA binding +namespace: molecular_function +def: "Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "acyl-CoA or acyl binding" BROAD [] +is_a: GO:0005504 ! fatty acid binding +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0000064 +name: L-ornithine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] +synonym: "L-ornithine transporter activity" BROAD [] +xref: Reactome:20635 +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0000066 +name: mitochondrial ornithine transport +namespace: biological_process +def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015822 ! ornithine transport + +[Term] +id: GO:0000067 +name: DNA replication and chromosome cycle +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept. +is_obsolete: true +consider: GO:0006260 +consider: GO:0007059 +consider: GO:0051276 + +[Term] +id: GO:0000070 +name: mitotic sister chromatid segregation +namespace: biological_process +alt_id: GO:0016359 +def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai] +synonym: "mitotic chromosome segregation" EXACT [] +synonym: "mitotic sister-chromatid adhesion release" NARROW [] +is_a: GO:0000819 ! sister chromatid segregation +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0000072 +name: M phase specific microtubule process +namespace: biological_process +def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] +synonym: "M-phase specific microtubule process" EXACT [] +is_a: GO:0007017 ! microtubule-based process +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0000073 +name: spindle pole body separation +namespace: biological_process +alt_id: GO:0030475 +def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] +synonym: "spindle pole body separation (sensu Fungi)" EXACT [] +synonym: "spindle pole body separation (sensu Saccharomyces)" NARROW [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051300 ! spindle pole body organization + +[Term] +id: GO:0000075 +name: cell cycle checkpoint +namespace: biological_process +def: "A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194] +xref: Reactome:212094 +xref: Reactome:221853 +xref: Reactome:230421 +xref: Reactome:238463 +xref: Reactome:245004 +xref: Reactome:249905 +xref: Reactome:252621 +xref: Reactome:255806 +xref: Reactome:259199 +xref: Reactome:262557 +xref: Reactome:265381 +xref: Reactome:268515 +xref: Reactome:274237 +xref: Reactome:280705 +xref: Reactome:282912 +xref: Reactome:286730 +xref: Reactome:69620 +is_a: GO:0051726 ! regulation of cell cycle + +[Term] +id: GO:0000076 +name: DNA replication checkpoint +namespace: biological_process +def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518] +is_a: GO:0031570 ! DNA integrity checkpoint +is_a: GO:0032297 ! negative regulation of DNA replication initiation + +[Term] +id: GO:0000077 +name: DNA damage checkpoint +namespace: biological_process +def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124] +synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] +is_a: GO:0031570 ! DNA integrity checkpoint +is_a: GO:0042770 ! DNA damage response, signal transduction + +[Term] +id: GO:0000078 +name: cell morphogenesis checkpoint +namespace: biological_process +def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188] +is_a: GO:0007093 ! mitotic cell cycle checkpoint +relationship: part_of GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0000079 +name: regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators] +synonym: "regulation of CDK activity" EXACT [] +is_a: GO:0045859 ! regulation of protein kinase activity +is_a: GO:0051726 ! regulation of cell cycle + +[Term] +id: GO:0000080 +name: G1 phase of mitotic cell cycle +namespace: biological_process +def: "Progression through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [ISBN:0815316194] +xref: Reactome:212033 +xref: Reactome:221797 +xref: Reactome:230372 +xref: Reactome:238411 +xref: Reactome:69236 +is_a: GO:0051318 ! G1 phase +relationship: part_of GO:0051329 ! interphase of mitotic cell cycle + +[Term] +id: GO:0000082 +name: G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah] +xref: Reactome:212021 +xref: Reactome:221784 +xref: Reactome:230362 +xref: Reactome:238403 +xref: Reactome:244953 +xref: Reactome:249850 +xref: Reactome:252607 +xref: Reactome:255745 +xref: Reactome:259140 +xref: Reactome:262495 +xref: Reactome:265325 +xref: Reactome:268498 +xref: Reactome:274174 +xref: Reactome:280647 +xref: Reactome:282899 +xref: Reactome:286666 +xref: Reactome:288375 +xref: Reactome:289876 +xref: Reactome:290408 +xref: Reactome:291794 +xref: Reactome:293774 +xref: Reactome:69206 +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051329 ! interphase of mitotic cell cycle + +[Term] +id: GO:0000083 +name: regulation of transcription of G1/S-phase of mitotic cell cycle +namespace: biological_process +def: "Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "G1/S-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" RELATED [] +xref: Reactome:69205 +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle + +[Term] +id: GO:0000084 +name: S phase of mitotic cell cycle +namespace: biological_process +def: "Progression through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [ISBN:0815316194] +is_a: GO:0051320 ! S phase +relationship: part_of GO:0051329 ! interphase of mitotic cell cycle + +[Term] +id: GO:0000085 +name: G2 phase of mitotic cell cycle +namespace: biological_process +def: "Progression through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [ISBN:0815316194] +xref: Reactome:211891 +xref: Reactome:221655 +xref: Reactome:230246 +xref: Reactome:238281 +xref: Reactome:244852 +xref: Reactome:249746 +xref: Reactome:268392 +xref: Reactome:274099 +xref: Reactome:280573 +xref: Reactome:68911 +is_a: GO:0051319 ! G2 phase +relationship: part_of GO:0051329 ! interphase of mitotic cell cycle + +[Term] +id: GO:0000086 +name: G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah] +xref: Reactome:211972 +xref: Reactome:221737 +xref: Reactome:230316 +xref: Reactome:238398 +xref: Reactome:244912 +xref: Reactome:249804 +xref: Reactome:252543 +xref: Reactome:255721 +xref: Reactome:259114 +xref: Reactome:262473 +xref: Reactome:265322 +xref: Reactome:268466 +xref: Reactome:274171 +xref: Reactome:280644 +xref: Reactome:282855 +xref: Reactome:286663 +xref: Reactome:69275 +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051329 ! interphase of mitotic cell cycle + +[Term] +id: GO:0000087 +name: M phase of mitotic cell cycle +namespace: biological_process +def: "Progression through M phase, the part of the mitotic cell cycle during which mitosis takes place." [GOC:mah, ISBN:0815316194] +synonym: "M-phase of mitotic cell cycle" EXACT [] +xref: Reactome:212043 +xref: Reactome:221806 +xref: Reactome:230379 +xref: Reactome:238418 +xref: Reactome:244995 +xref: Reactome:249877 +xref: Reactome:252596 +xref: Reactome:255795 +xref: Reactome:259176 +xref: Reactome:262532 +xref: Reactome:265359 +xref: Reactome:268488 +xref: Reactome:282892 +xref: Reactome:286702 +xref: Reactome:68886 +is_a: GO:0000279 ! M phase +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0000088 +name: mitotic prophase +namespace: biological_process +def: "Progression through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [ISBN:0815316194] +xref: Reactome:211977 +xref: Reactome:221742 +xref: Reactome:230322 +xref: Reactome:238359 +xref: Reactome:244917 +xref: Reactome:249807 +xref: Reactome:252546 +xref: Reactome:255723 +xref: Reactome:259116 +xref: Reactome:262475 +xref: Reactome:268434 +xref: Reactome:286639 +xref: Reactome:68875 +is_a: GO:0051324 ! prophase +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0000089 +name: mitotic metaphase +namespace: biological_process +def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194] +xref: Reactome:68879 +is_a: GO:0051323 ! metaphase +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0000090 +name: mitotic anaphase +namespace: biological_process +def: "Progression through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [ISBN:0815316194] +xref: Reactome:68882 +is_a: GO:0051322 ! anaphase +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0000091 +name: mitotic anaphase A +namespace: biological_process +def: "Progression through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [ISBN:0815316194] +is_a: GO:0000090 ! mitotic anaphase + +[Term] +id: GO:0000092 +name: mitotic anaphase B +namespace: biological_process +def: "Progression through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [ISBN:0815316194] +is_a: GO:0000090 ! mitotic anaphase + +[Term] +id: GO:0000093 +name: mitotic telophase +namespace: biological_process +def: "Progression through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0051326 ! telophase +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0000094 +name: septin assembly and septum formation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was not defined and the string name implied two separate processes. +is_obsolete: true +consider: GO:0000917 +consider: GO:0000918 +consider: GO:0000921 + +[Term] +id: GO:0000095 +name: S-adenosylmethionine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015177 +def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] +synonym: "S-adenosyl methionine permease activity" EXACT [] +synonym: "S-adenosyl methionine transporter activity" EXACT [] +synonym: "S-adenosylmethionine permease activity" EXACT [] +synonym: "S-adenosylmethionine transporter activity" BROAD [] +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0000096 +name: sulfur amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] +subset: gosubset_prok +synonym: "sulfur amino acid metabolism" EXACT [] +synonym: "sulphur amino acid metabolic process" EXACT [] +synonym: "sulphur amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0000097 +name: sulfur amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] +subset: gosubset_prok +synonym: "sulfur amino acid anabolism" EXACT [] +synonym: "sulfur amino acid biosynthesis" EXACT [] +synonym: "sulfur amino acid formation" EXACT [] +synonym: "sulfur amino acid synthesis" EXACT [] +synonym: "sulphur amino acid biosynthesis" EXACT [] +synonym: "sulphur amino acid biosynthetic process" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0000098 +name: sulfur amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] +subset: gosubset_prok +synonym: "sulfur amino acid breakdown" EXACT [] +synonym: "sulfur amino acid catabolism" EXACT [] +synonym: "sulfur amino acid degradation" EXACT [] +synonym: "sulphur amino acid catabolic process" EXACT [] +synonym: "sulphur amino acid catabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0000099 +name: sulfur amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "sulfur amino acid transporter activity" BROAD [] +synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] +synonym: "sulphur amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0000100 +name: S-methylmethionine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015178 +def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "S-methylmethionine permease activity" EXACT [] +synonym: "S-methylmethionine transporter activity" BROAD [] +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity + +[Term] +id: GO:0000101 +name: sulfur amino acid transport +namespace: biological_process +def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "sulphur amino acid transport" EXACT [] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0000102 +name: L-methionine secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "L-methionine porter activity" RELATED [] +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity +is_a: GO:0015191 ! L-methionine transmembrane transporter activity + +[Term] +id: GO:0000103 +name: sulfate assimilation +namespace: biological_process +def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] +subset: gosubset_prok +synonym: "sulphate assimilation" EXACT [] +is_a: GO:0006791 ! sulfur utilization + +[Term] +id: GO:0000104 +name: succinate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0019739 +def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. No reaction with quinols." [EC:1.3.99.1, GOC:kd] +subset: gosubset_prok +synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] +synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] +synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] +synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] +synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] +synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] +synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] +synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] +synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] +synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] +xref: EC:1.3.99.1 +xref: MetaCyc:SUCC-FUM-OXRED-RXN +xref: Reactome:21566 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0000105 +name: histidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine anabolism" EXACT [] +synonym: "histidine biosynthesis" EXACT [] +synonym: "histidine formation" EXACT [] +synonym: "histidine synthesis" EXACT [] +xref: MetaCyc:HISTSYN-PWY +is_a: GO:0006547 ! histidine metabolic process +is_a: GO:0009076 ! histidine family amino acid biosynthetic process + +[Term] +id: GO:0000107 +name: imidazoleglycerol-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate." [MetaCyc:GLUTAMIDOTRANS-RXN] +subset: gosubset_prok +synonym: "glutamine amidotransferase:cyclase activity" BROAD [] +synonym: "imidazole glycerol phosphate synthase activity" EXACT [] +synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] +synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] +xref: EC:2.4.2.- +xref: MetaCyc:GLUTAMIDOTRANS-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0000108 +name: repairosome +namespace: cellular_component +def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000109 +name: nucleotide-excision repair complex +namespace: cellular_component +def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] +comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000110 +name: nucleotide-excision repair factor 1 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p." [PMID:10915862] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF1 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000111 +name: nucleotide-excision repair factor 2 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF2 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000112 +name: nucleotide-excision repair factor 3 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF3 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000113 +name: nucleotide-excision repair factor 4 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF4 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000114 +name: regulation of transcription during G1 phase of mitotic cell cycle +namespace: biological_process +def: "Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle + +[Term] +id: GO:0000115 +name: regulation of transcription during S-phase of mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] +synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] +synonym: "S-specific transcription in mitotic cell cycle" EXACT [] +xref: Reactome:69241 +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000084 ! S phase of mitotic cell cycle + +[Term] +id: GO:0000116 +name: regulation of transcription during G2-phase of mitotic cell cycle +namespace: biological_process +def: "Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle + +[Term] +id: GO:0000117 +name: regulation of transcription during G2/M-phase of mitotic cell cycle +namespace: biological_process +def: "Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" RELATED [] +xref: Reactome:69274 +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0000118 +name: histone deacetylase complex +namespace: cellular_component +def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] +comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. +synonym: "HDAC complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0000119 +name: mediator complex +namespace: cellular_component +def: "A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription." [PMID:10384286, PMID:11114191, PMID:8187178, PMID:9396788, PMID:9774831] +synonym: "S mediator complex" EXACT [] +synonym: "TRAP complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0000120 +name: RNA polymerase I transcription factor complex +namespace: cellular_component +def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah] +is_a: GO:0005667 ! transcription factor complex +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0000121 +name: glycerol-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] +synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] +synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] +synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] +synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] +synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] +synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] +xref: EC:3.1.3.21 +xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0000122 +name: negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter" NARROW [] +synonym: "negative regulation of transcription from Pol II promoter" EXACT [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0000123 +name: histone acetyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] +comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. +synonym: "histone acetylase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0000124 +name: SAGA complex +namespace: cellular_component +def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] +synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0000125 +name: PCAF complex +namespace: cellular_component +def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] +comment: See also the cellular component term 'SAGA complex ; GO:0000124'. +synonym: "PCAF histone acetylase-associated complex" EXACT [] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0000126 +name: transcription factor TFIIIB complex +namespace: cellular_component +def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0000127 +name: transcription factor TFIIIC complex +namespace: cellular_component +def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species." [GOC:mah, PMID:11433012] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0000128 +name: flocculation +namespace: biological_process +def: "The non-sexual aggregation of single-celled organisms." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0000131 +name: incipient cellular bud site +namespace: cellular_component +def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000132 +name: establishment of mitotic spindle orientation +namespace: biological_process +alt_id: GO:0030607 +alt_id: GO:0030609 +def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] +synonym: "establishment of spindle orientation during mitosis" EXACT [] +synonym: "mitotic spindle orientation" EXACT [] +synonym: "mitotic spindle orientation (sensu Fungi)" NARROW [] +synonym: "mitotic spindle orientation (sensu Saccharomyces)" NARROW [] +synonym: "orienting of mitotic spindle" EXACT [] +is_a: GO:0040001 ! establishment of mitotic spindle localization +is_a: GO:0051294 ! establishment of spindle orientation + +[Term] +id: GO:0000133 +name: polarisome +namespace: cellular_component +def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0030427 ! site of polarized growth + +[Term] +id: GO:0000135 +name: septin checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642] +is_a: GO:0031565 ! cytokinesis checkpoint + +[Term] +id: GO:0000136 +name: alpha-1,6-mannosyltransferase complex +namespace: cellular_component +def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735] +is_a: GO:0031501 ! mannosyltransferase complex +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0000137 ! Golgi cis cisterna + +[Term] +id: GO:0000137 +name: Golgi cis cisterna +namespace: cellular_component +def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] +is_a: GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0000138 +name: Golgi trans cisterna +namespace: cellular_component +def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] +is_a: GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0000139 +name: Golgi membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0000140 +name: acylglycerone-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101] +synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] +synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] +synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] +synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] +synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] +synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] +xref: EC:1.1.1.101 +xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN +xref: Reactome:21659 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000142 +name: cellular bud neck contractile ring +namespace: cellular_component +def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] +synonym: "actomyosin ring (sensu Saccharomyces)" BROAD [] +synonym: "contractile ring (sensu Saccharomyces)" EXACT [] +synonym: "cytokinetic ring (sensu Saccharomyces)" BROAD [] +synonym: "neck ring" EXACT [] +is_a: GO:0005826 ! contractile ring +relationship: part_of GO:0005935 ! cellular bud neck + +[Term] +id: GO:0000144 +name: cellular bud neck septin ring +namespace: cellular_component +def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] +synonym: "septin ring (sensu Saccharomyces)" EXACT [] +is_a: GO:0000399 ! cellular bud neck septin structure +is_a: GO:0005940 ! septin ring +is_a: GO:0032161 ! cleavage apparatus septin structure + +[Term] +id: GO:0000145 +name: exocyst +namespace: cellular_component +def: "A protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] +synonym: "Sec6/8 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044448 ! cell cortex part + +[Term] +id: GO:0000146 +name: microfilament motor activity +namespace: molecular_function +def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] +synonym: "actin filament motor activity" EXACT [GOC:dph] +synonym: "actin-filament motor activity" EXACT [] +synonym: "muscle motor activity" NARROW [] +synonym: "myosin ATPase activity" RELATED [] +is_a: GO:0003774 ! motor activity + +[Term] +id: GO:0000147 +name: actin cortical patch assembly +namespace: biological_process +def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0030866 ! cortical actin cytoskeleton organization + +[Term] +id: GO:0000148 +name: 1,3-beta-glucan synthase complex +namespace: cellular_component +def: "A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0000149 +name: SNARE binding +namespace: molecular_function +def: "Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] +synonym: "SNAP receptor binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0000150 +name: recombinase activity +namespace: molecular_function +def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] +comment: Consider also annotating to the molecular function terms 'double-stranded DNA binding ; GO:0003690' and 'single-stranded DNA binding ; GO:0003697'. Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. +subset: gosubset_prok +synonym: "strand transferase" NARROW [] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0000151 +name: ubiquitin ligase complex +namespace: cellular_component +def: "A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex." [PMID:9529603] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000152 +name: nuclear ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] +is_a: GO:0000151 ! ubiquitin ligase complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000153 +name: cytoplasmic ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] +is_a: GO:0000151 ! ubiquitin ligase complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000154 +name: rRNA modification +namespace: biological_process +alt_id: GO:0016548 +def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. +subset: gosubset_prok +synonym: "rRNA editing" EXACT [] +is_a: GO:0006364 ! rRNA processing +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0000155 +name: two-component sensor activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell." [GOC:mah] +subset: gosubset_prok +synonym: "two-component sensor molecule" NARROW [] +synonym: "two-component system sensor activity " EXACT [] +xref: EC:2.7.3.- +is_a: GO:0004673 ! protein histidine kinase activity +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0000156 +name: two-component response regulator activity +namespace: molecular_function +def: "Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell." [GOC:mah] +subset: gosubset_prok +is_a: GO:0004871 ! signal transducer activity +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0000159 +name: protein phosphatase type 2A complex +namespace: cellular_component +def: "A heterodimer with protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic and regulatory subunits." [GOC:mah, ISBN:0198547684] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000160 +name: two-component signal transduction system (phosphorelay) +namespace: biological_process +def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] +subset: gosubset_prok +synonym: "histidyl-aspartyl phosphorelay" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0000161 +name: MAPKKK cascade during osmolarity sensing +namespace: biological_process +def: "MAPKKK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267] +synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] +is_a: GO:0000165 ! MAPKKK cascade +relationship: part_of GO:0007231 ! osmosensory signaling pathway + +[Term] +id: GO:0000162 +name: tryptophan biosynthetic process +namespace: biological_process +alt_id: GO:0009096 +def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", MetaCyc:TRPSYN-PWY] +subset: gosubset_prok +synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] +synonym: "tryptophan anabolism" EXACT [] +synonym: "tryptophan biosynthesis" EXACT [] +synonym: "tryptophan formation" EXACT [] +synonym: "tryptophan synthesis" EXACT [] +xref: MetaCyc:TRPSYN-PWY +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0009073 ! aromatic amino acid family biosynthetic process +is_a: GO:0046219 ! indolalkylamine biosynthetic process + +[Term] +id: GO:0000164 +name: protein phosphatase type 1 complex +namespace: cellular_component +def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000165 +name: MAPKKK cascade +namespace: biological_process +def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GOC:mah, PMID:9561267] +synonym: "ERK/MAPK cascade" EXACT [] +synonym: "MAP kinase cascade" EXACT [] +synonym: "MAP kinase kinase kinase cascade" EXACT [] +synonym: "MAPK cascade" EXACT [] +synonym: "MAPK signaling" RELATED [] +synonym: "MAPK signalling" RELATED [] +synonym: "MAPKKK cascade during sporulation (sensu Fungi)" NARROW [] +synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" NARROW [] +xref: Reactome:109869 +xref: Reactome:211967 +xref: Reactome:221732 +xref: Reactome:230313 +xref: Reactome:238351 +xref: Reactome:244909 +xref: Reactome:249802 +xref: Reactome:252619 +xref: Reactome:255804 +xref: Reactome:259197 +xref: Reactome:262555 +xref: Reactome:268509 +xref: Reactome:274234 +xref: Reactome:280703 +xref: Reactome:286727 +is_a: GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0000166 +name: nucleotide binding +namespace: molecular_function +def: "Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety." [GOC:mah, ISBN:0198547684] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0000167 +name: activation of MAPKKK activity during osmolarity sensing +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] +synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT [] +synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT [] +synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT [] +is_a: GO:0000185 ! activation of MAPKKK activity +relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing + +[Term] +id: GO:0000168 +name: activation of MAPKK activity during osmolarity sensing +namespace: biological_process +alt_id: GO:0007233 +def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] +synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT [] +synonym: "activation of Pbs2 kinase" NARROW [] +synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT [] +synonym: "osmolarity sensing, activation of MAPKK activity" EXACT [] +is_a: GO:0000186 ! activation of MAPKK activity +relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing + +[Term] +id: GO:0000169 +name: activation of MAPK activity during osmolarity sensing +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] +synonym: "osmolarity sensing, activation of MAPK activity" EXACT [] +is_a: GO:0000187 ! activation of MAPK activity +relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing + +[Term] +id: GO:0000170 +name: sphingosine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0000171 +name: ribonuclease MRP activity +namespace: molecular_function +def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA_mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] +synonym: "RNase MRP" EXACT [] +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0000172 +name: ribonuclease MRP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] +synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] +synonym: "RNase MRP complex" EXACT [] +is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex + +[Term] +id: GO:0000173 +name: inactivation of MAPK activity during osmolarity sensing +namespace: biological_process +def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] +synonym: "osmolarity sensing, inactivation of MAPK" EXACT [] +synonym: "osmolarity sensing, termination of MAPK activity" EXACT [] +synonym: "termination of MAPK activity during osmolarity sensing" EXACT [] +is_a: GO:0000188 ! inactivation of MAPK activity +relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing + +[Term] +id: GO:0000174 +name: inactivation of MAPK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0000175 +name: 3'-5'-exoribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "3'-5' exoribonuclease activity" EXACT [] +xref: EC:3.1.13.- +is_a: GO:0008408 ! 3'-5' exonuclease activity +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0000176 +name: nuclear exosome (RNase complex) +namespace: cellular_component +def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] +synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] +synonym: "nuclear exosome (ribonuclease complex)" EXACT [] +synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] +is_a: GO:0000178 ! exosome (RNase complex) +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000177 +name: cytoplasmic exosome (RNase complex) +namespace: cellular_component +def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] +synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] +synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] +synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] +is_a: GO:0000178 ! exosome (RNase complex) +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000178 +name: exosome (RNase complex) +namespace: cellular_component +def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] +comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. +subset: goslim_pir +synonym: "exosome (ribonucleasease complex)" EXACT [] +synonym: "exosome multienzyme ribonuclease complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000179 +name: rRNA (adenine-N6,N6-)-dimethyltransferase activity +namespace: molecular_function +def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337 "Modification and Editing of RNA", PMID:10690410] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0000180 +name: cytosolic large ribosomal subunit +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because more specific children exist. +is_obsolete: true +consider: GO:0022625 + +[Term] +id: GO:0000181 +name: cytosolic small ribosomal subunit +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because more specific children exist. +is_obsolete: true +consider: GO:0022627 + +[Term] +id: GO:0000182 +name: rDNA binding +namespace: molecular_function +def: "Interacting selectively with DNA sequences encoding ribosomal RNA." [GOC:mah] +synonym: "ribosomal DNA binding" EXACT [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0000183 +name: chromatin silencing at rDNA +namespace: biological_process +def: "Repression of transcription of ribosomal DNA by the formation of heterochromatin." [PMID:10219245] +synonym: "chromatin silencing at ribosomal DNA" EXACT [] +synonym: "heterochromatic silencing at rDNA" EXACT [] +is_a: GO:0006342 ! chromatin silencing + +[Term] +id: GO:0000184 +name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +namespace: biological_process +def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] +synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] +synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] +synonym: "mRNA catabolism, nonsense-mediated" EXACT [] +synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] +synonym: "nonsense-mediated mRNA decay" EXACT [] +synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000185 +name: activation of MAPKKK activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267] +synonym: "activation of MAP kinase kinase kinase" EXACT [] +synonym: "activation of MAPKKK during sporulation (sensu Fungi)" NARROW [] +synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" NARROW [] +synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] +synonym: "positive regulation of MAPKKK activity" BROAD [] +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0000186 +name: activation of MAPKK activity +namespace: biological_process +alt_id: GO:0007255 +def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267] +synonym: "activation of MAP kinase kinase activity" EXACT [] +synonym: "activation of MAP/ERK kinase kinase" EXACT [] +synonym: "activation of MAPKK during sporulation (sensu Fungi)" NARROW [] +synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" NARROW [] +synonym: "positive regulation of MAPKK activity" BROAD [] +xref: Reactome:110049 +xref: Reactome:211601 +xref: Reactome:221376 +xref: Reactome:230014 +xref: Reactome:238032 +xref: Reactome:244648 +xref: Reactome:249583 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0000187 +name: activation of MAPK activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267] +synonym: "activation of MAP kinase" EXACT [] +synonym: "activation of MAPK during sporulation (sensu Fungi)" NARROW [] +synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" NARROW [] +synonym: "MAPK activation" EXACT [] +xref: Reactome:112409 +xref: Reactome:212039 +xref: Reactome:221803 +xref: Reactome:230377 +xref: Reactome:238416 +xref: Reactome:244963 +xref: Reactome:249842 +xref: Reactome:252574 +xref: Reactome:255755 +xref: Reactome:259149 +xref: Reactome:262506 +xref: Reactome:268461 +xref: Reactome:274183 +xref: Reactome:280656 +xref: Reactome:286675 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0043406 ! positive regulation of MAP kinase activity +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0000188 +name: inactivation of MAPK activity +namespace: biological_process +def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] +synonym: "inactivation of MAPK during sporulation (sensu Fungi)" NARROW [] +synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" NARROW [] +synonym: "termination of MAPK activity" EXACT [] +is_a: GO:0043407 ! negative regulation of MAP kinase activity +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0000189 +name: nuclear translocation of MAPK +namespace: biological_process +def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] +xref: Reactome:109867 +xref: Reactome:109868 +xref: Reactome:112353 +xref: Reactome:209891 +xref: Reactome:209896 +xref: Reactome:228348 +xref: Reactome:228351 +xref: Reactome:236568 +xref: Reactome:236573 +xref: Reactome:243599 +xref: Reactome:243605 +xref: Reactome:248698 +xref: Reactome:248703 +xref: Reactome:251790 +xref: Reactome:251793 +xref: Reactome:254938 +xref: Reactome:254943 +xref: Reactome:258208 +xref: Reactome:258211 +xref: Reactome:261726 +xref: Reactome:261729 +xref: Reactome:267714 +xref: Reactome:267717 +xref: Reactome:273179 +xref: Reactome:273186 +xref: Reactome:279660 +xref: Reactome:279666 +xref: Reactome:285768 +xref: Reactome:285771 +is_a: GO:0000060 ! protein import into nucleus, translocation +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0000190 +name: MAPKKK cascade (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000191 +name: activation of MAPKKK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000192 +name: activation of MAPKK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000193 +name: activation of MAPK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000194 +name: inactivation of MAPK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000195 +name: nuclear translocation of MAPK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000196 +name: MAPKKK cascade during cell wall biogenesis +namespace: biological_process +def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase that occurs during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] +is_a: GO:0000165 ! MAPKKK cascade +relationship: part_of GO:0007047 ! cell wall organization + +[Term] +id: GO:0000197 +name: activation of MAPKKK activity during cell wall biogenesis +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] +synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] +synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] +is_a: GO:0000185 ! activation of MAPKKK activity +relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis + +[Term] +id: GO:0000198 +name: activation of MAPKK activity during cell wall biogenesis +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] +synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] +synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] +is_a: GO:0000186 ! activation of MAPKK activity +relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis + +[Term] +id: GO:0000199 +name: activation of MAPK activity during cell wall biogenesis +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme MAP kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] +is_a: GO:0000187 ! activation of MAPK activity +relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis + +[Term] +id: GO:0000200 +name: inactivation of MAPK activity during cell wall biogenesis +namespace: biological_process +def: "Any process that terminates the activity of the active enzyme MAP kinase during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] +synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] +synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] +is_a: GO:0000188 ! inactivation of MAPK activity +relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis + +[Term] +id: GO:0000201 +name: nuclear translocation of MAPK during cell wall biogenesis +namespace: biological_process +def: "The directed movement of a MAP kinase to the nucleus during cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +synonym: "cell wall biogenesis, nuclear translocation of MAPK" EXACT [] +is_a: GO:0000189 ! nuclear translocation of MAPK +relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis + +[Term] +id: GO:0000202 +name: MAPKKK cascade during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000203 +name: activation of MAPKKK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000204 +name: activation of MAPKK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000205 +name: activation of MAPK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000206 +name: inactivation of MAPK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000207 +name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0000208 +name: nuclear translocation of MAPK during osmolarity sensing +namespace: biological_process +def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] +synonym: "osmolarity sensing, nuclear translocation of MAPK" EXACT [] +is_a: GO:0000189 ! nuclear translocation of MAPK +relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing + +[Term] +id: GO:0000209 +name: protein polyubiquitination +namespace: biological_process +def: "Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain." [ISBN:0815316194] +synonym: "polyubiquitin" RELATED [] +synonym: "protein polyubiquitinylation" EXACT [] +synonym: "protein polyubiquitylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0000210 +name: NAD+ diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] +subset: gosubset_prok +synonym: "NAD diphosphatase activity" EXACT [] +synonym: "NAD pyrophosphatase activity" EXACT [] +synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] +synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] +synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] +synonym: "NADH pyrophosphatase activity" EXACT [EC:3.6.1.22] +synonym: "NADP pyrophosphatase activity" EXACT [EC:3.6.1.22] +synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] +xref: EC:3.6.1.22 +xref: MetaCyc:NADPYROPHOSPHAT-RXN +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0000211 +name: protein degradation tagging activity +namespace: molecular_function +def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] +comment: This term was made obsolete because it represents a biological process and a molecular function. +is_obsolete: true +consider: GO:0005515 +consider: GO:0019941 +consider: GO:0042787 + +[Term] +id: GO:0000212 +name: meiotic spindle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] +synonym: "meiotic spindle organisation and biogenesis" EXACT [] +synonym: "meiotic spindle organization and biogenesis" EXACT [] +synonym: "spindle organization and biogenesis during meiosis" EXACT [] +is_a: GO:0007051 ! spindle organization +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0000213 +name: tRNA-intron endonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] +synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] +synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] +synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] +synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] +synonym: "tRNA-intron endoribonuclease activity" EXACT [] +synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] +synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] +xref: EC:3.1.27.9 +xref: MetaCyc:3.1.27.9-RXN +is_a: GO:0004549 ! tRNA-specific ribonuclease activity +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0000214 +name: tRNA-intron endonuclease complex +namespace: cellular_component +def: "A complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000215 +name: tRNA 2'-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O; transfers the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] +synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] +synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] +synonym: "Tpt1" RELATED [EC:2.7.1.160] +synonym: "Tpt1p" RELATED [EC:2.7.1.160] +synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] +xref: EC:2.7.1.160 +is_a: GO:0008665 ! 2'-phosphotransferase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0000216 +name: M/G1 transition of mitotic cell cycle +namespace: biological_process +def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah] +xref: Reactome:211997 +xref: Reactome:221761 +xref: Reactome:230342 +xref: Reactome:238378 +xref: Reactome:244933 +xref: Reactome:249898 +xref: Reactome:252623 +xref: Reactome:255800 +xref: Reactome:259165 +xref: Reactome:262551 +xref: Reactome:265375 +xref: Reactome:274161 +xref: Reactome:280634 +xref: Reactome:286652 +xref: Reactome:68874 +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051329 ! interphase of mitotic cell cycle + +[Term] +id: GO:0000217 +name: DNA secondary structure binding +namespace: molecular_function +def: "Interacting selectively with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0000219 +name: vacuolar hydrogen-transporting ATPase +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "V-ATPase" EXACT [] +is_obsolete: true +consider: GO:0016469 + +[Term] +id: GO:0000220 +name: vacuolar proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] +comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. +synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] +is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex + +[Term] +id: GO:0000221 +name: vacuolar proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] +comment: Note that this domain generally consists of eight subunits. +synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] +is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex + +[Term] +id: GO:0000222 +name: plasma membrane proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] +synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] +is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane +relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex + +[Term] +id: GO:0000223 +name: plasma membrane proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] +synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] +is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane +relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex + +[Term] +id: GO:0000224 +name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] +subset: gosubset_prok +synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] +synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] +synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] +synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] +synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] +synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] +synonym: "peptide:N-glycanase" RELATED [] +synonym: "PNGase" EXACT [] +synonym: "PNGase A" RELATED [EC:3.5.1.52] +synonym: "PNGase F" RELATED [EC:3.5.1.52] +xref: EC:3.5.1.52 +xref: MetaCyc:3.5.1.52-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0000225 +name: N-acetylglucosaminylphosphatidylinositol deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI." [EC:3.5.1.89] +comment: Note that this function was formerly EC:3.1.1.69. +synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] +synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] +synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] +synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] +synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] +synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] +xref: EC:3.5.1.89 +xref: MetaCyc:3.1.1.69-RXN +xref: Reactome:22619 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0000226 +name: microtubule cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] +synonym: "microtubule cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0007017 ! microtubule-based process + +[Term] +id: GO:0000227 +name: oxaloacetate secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "oxaloacetate carrier activity" RELATED [] +is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0000228 +name: nuclear chromosome +namespace: cellular_component +def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] +subset: goslim_generic +synonym: "nuclear interphase chromosome" NARROW [] +is_a: GO:0005694 ! chromosome +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000229 +name: cytoplasmic chromosome +namespace: cellular_component +def: "A chromosome found in the cytoplasm." [GOC:mah] +subset: goslim_generic +subset: gosubset_prok +synonym: "cytoplasmic interphase chromosome" NARROW [] +is_a: GO:0005694 ! chromosome +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000230 +name: nuclear mitotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0000794 + +[Term] +id: GO:0000231 +name: cytoplasmic mitotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0000793 + +[Term] +id: GO:0000232 +name: nuclear interphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0000228 + +[Term] +id: GO:0000233 +name: cytoplasmic interphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0000229 + +[Term] +id: GO:0000234 +name: phosphoethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] +synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] +synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] +xref: EC:2.1.1.103 +xref: MetaCyc:2.1.1.103-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0000235 +name: astral microtubule +namespace: cellular_component +def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] +is_a: GO:0005876 ! spindle microtubule +is_a: GO:0005881 ! cytoplasmic microtubule +relationship: part_of GO:0005818 ! aster + +[Term] +id: GO:0000236 +name: mitotic prometaphase +namespace: biological_process +def: "Progression through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mah, ISBN:0198547684] +xref: Reactome:68877 +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0000237 +name: leptotene +namespace: biological_process +def: "Progression through the first stage of prophase I in meiosis, in which chromosomes first become visible." [ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000238 +name: zygotene +namespace: biological_process +def: "Progression through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000239 +name: pachytene +namespace: biological_process +def: "Progression through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000240 +name: diplotene +namespace: biological_process +def: "Progression through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000241 +name: diakinesis +namespace: biological_process +def: "Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000242 +name: pericentriolar material +namespace: cellular_component +def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0000243 +name: commitment complex +namespace: cellular_component +def: "The first portion of the spliceosome to assemble in mRNA splicing; in commitment complex formation the 5' and 3' splice sites are recognized by the U1 snRNP and the U2 snRNP auxiliary factor, respectively." [PMID:9159080] +synonym: "E complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005681 ! spliceosome + +[Term] +id: GO:0000244 +name: assembly of spliceosomal tri-snRNP +namespace: biological_process +alt_id: GO:0000351 +alt_id: GO:0000355 +def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] +synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] +synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] +synonym: "snRNP recycling" BROAD [] +synonym: "spliceosomal tri-snRNP assembly" EXACT [] +synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] +synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000387 ! spliceosomal snRNP biogenesis + +[Term] +id: GO:0000245 +name: spliceosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000246 +name: delta24(24-1) sterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+." [EC:1.3.1.71, PMID:10722850] +subset: gosubset_prok +synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] +synonym: "D24(24-1)-sterol reductase activity" EXACT [] +synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] +synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] +synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] +synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] +synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] +synonym: "sterol delta-24(28) reductase activity" EXACT [] +synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] +synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] +xref: EC:1.3.1.71 +xref: MetaCyc:1.3.1.71-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000247 +name: C-8 sterol isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [UniProtKB:P32352] +synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] +xref: EC:5.3.3.- +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0000248 +name: C-5 sterol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] +synonym: "sterol-C5-desaturase activity" EXACT [] +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0000249 +name: C-22 sterol desaturase activity +namespace: molecular_function +def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction is 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227, UniProtKB:P54781] +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0000250 +name: lanosterol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7] +subset: gosubset_prok +synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] +synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] +synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] +synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] +synonym: "2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] +synonym: "2,3-oxidosqualene sterol cyclase activity" EXACT [EC:5.4.99.7] +synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] +synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] +synonym: "OSC" EXACT [] +synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] +synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] +synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] +synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] +synonym: "squalene epoxidase-cyclase activity" EXACT [EC:5.4.99.7] +synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] +xref: EC:5.4.99.7 +xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN +xref: Reactome:22668 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0000252 +name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] +synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] +synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] +synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] +synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] +synonym: "C-3 sterol dehydrogenase activity" RELATED [] +synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] +synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] +synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000253 +name: 3-keto sterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + NADPH + H+." [EC:1.1.1.270, PMID:9811880] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000254 +name: C-4 methylsterol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] +synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] +synonym: "4-methylsterol oxidase activity" EXACT [] +synonym: "methylsterol hydroxylase activity" RELATED [] +synonym: "methylsterol monooxygenase activity" RELATED [] +xref: EC:1.14.13.72 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0000255 +name: allantoin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "allantoin metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0000256 +name: allantoin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "allantoin breakdown" EXACT [] +synonym: "allantoin catabolism" EXACT [] +synonym: "allantoin degradation" EXACT [] +is_a: GO:0000255 ! allantoin metabolic process +is_a: GO:0046700 ! heterocycle catabolic process + +[Term] +id: GO:0000257 +name: nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] +subset: gosubset_prok +synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] +synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] +synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] +xref: EC:3.5.5.1 +xref: MetaCyc:3.5.5.1-RXN +xref: UM-BBD_enzymeID:e0283 +is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles + +[Term] +id: GO:0000258 +name: isoleucine/valine:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005283 +consider: GO:0005304 +consider: GO:0015188 + +[Term] +id: GO:0000259 +name: intracellular nucleoside transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] +comment: This term was made obsolete because it contains component and function information. +is_obsolete: true +replaced_by: GO:0005337 +replaced_by: GO:0005622 + +[Term] +id: GO:0000260 +name: hydrogen-translocating V-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0046961 + +[Term] +id: GO:0000261 +name: sodium-translocating V-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0046962 + +[Term] +id: GO:0000262 +name: mitochondrial chromosome +namespace: cellular_component +def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] +synonym: "mitochondrial DNA" NARROW [] +synonym: "mitochondrial genome" RELATED [] +synonym: "mtDNA" NARROW [] +is_a: GO:0000229 ! cytoplasmic chromosome +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0042645 ! mitochondrial nucleoid + +[Term] +id: GO:0000263 +name: heterotrimeric G-protein GTPase, alpha-subunit +namespace: molecular_function +def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0003924 +consider: GO:0005834 + +[Term] +id: GO:0000264 +name: heterotrimeric G-protein GTPase, beta-subunit +namespace: molecular_function +def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0003924 +consider: GO:0005834 + +[Term] +id: GO:0000265 +name: heterotrimeric G-protein GTPase, gamma-subunit +namespace: molecular_function +def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0003924 +consider: GO:0005834 + +[Term] +id: GO:0000266 +name: mitochondrial fission +namespace: biological_process +def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] +synonym: "mitochondrial division" EXACT [] +synonym: "mitochondrial proliferation" RELATED [] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0000267 +name: cell fraction +namespace: cellular_component +def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0000268 +name: peroxisome targeting sequence binding +namespace: molecular_function +alt_id: GO:0005051 +def: "Interacting selectively with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] +synonym: "peroxisome targeting signal receptor" NARROW [] +synonym: "PTS binding" EXACT [] +synonym: "PTS receptor" NARROW [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0000269 +name: toxin export channel activity +namespace: molecular_function +def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +is_a: GO:0015288 ! porin activity +is_a: GO:0019534 ! toxin transporter activity + +[Term] +id: GO:0000270 +name: peptidoglycan metabolic process +namespace: biological_process +alt_id: GO:0009284 +def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "murein metabolic process" EXACT [] +synonym: "murein metabolism" EXACT [] +synonym: "peptidoglycan metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0000271 +name: polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycan biosynthesis" EXACT [] +synonym: "glycan biosynthetic process" EXACT [] +synonym: "polysaccharide anabolism" EXACT [] +synonym: "polysaccharide biosynthesis" EXACT [] +synonym: "polysaccharide formation" EXACT [] +synonym: "polysaccharide synthesis" EXACT [] +is_a: GO:0016051 ! carbohydrate biosynthetic process +is_a: GO:0043284 ! biopolymer biosynthetic process + +[Term] +id: GO:0000272 +name: polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] +subset: gosubset_prok +synonym: "polysaccharide breakdown" EXACT [] +synonym: "polysaccharide catabolism" EXACT [] +synonym: "polysaccharide degradation" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process +is_a: GO:0043285 ! biopolymer catabolic process + +[Term] +id: GO:0000273 +name: lipoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "lipoic acid metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0000274 +name: mitochondrial proton-transporting ATP synthase, stator stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Eukaryota)" EXACT [] +synonym: "proton-transporting ATP synthase, stator stalk (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk +relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) + +[Term] +id: GO:0000275 +name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) +namespace: cellular_component +def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] +synonym: "proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) +relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex + +[Term] +id: GO:0000276 +name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) +namespace: cellular_component +def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Eukaryota)" EXACT [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) +relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex + +[Term] +id: GO:0000277 +name: [cytochrome c]-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] +synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] +synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] +synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] +synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] +synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] +synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] +synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] +xref: EC:2.1.1.59 +xref: MetaCyc:2.1.1.59-RXN +is_a: GO:0016279 ! protein-lysine N-methyltransferase activity + +[Term] +id: GO:0000278 +name: mitotic cell cycle +namespace: biological_process +def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] +xref: Reactome:212083 +xref: Reactome:221841 +xref: Reactome:230408 +xref: Reactome:238450 +xref: Reactome:244991 +xref: Reactome:249871 +xref: Reactome:252608 +xref: Reactome:255794 +xref: Reactome:259188 +xref: Reactome:262544 +xref: Reactome:265374 +xref: Reactome:268486 +xref: Reactome:274210 +xref: Reactome:280680 +xref: Reactome:282900 +xref: Reactome:286715 +xref: Reactome:288392 +xref: Reactome:289890 +xref: Reactome:290421 +xref: Reactome:291802 +xref: Reactome:293782 +xref: Reactome:69278 +is_a: GO:0007049 ! cell cycle + +[Term] +id: GO:0000279 +name: M phase +namespace: biological_process +def: "Progression through M phase, the part of the cell cycle comprising nuclear division." [ISBN:0815316194] +synonym: "M-phase" EXACT [] +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0000280 +name: nuclear division +namespace: biological_process +def: "A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] +subset: goslim_pir +synonym: "karyokinesis" RELATED [] +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0000281 +name: cytokinesis after mitosis +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai] +is_a: GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0000282 +name: cellular bud site selection +namespace: biological_process +def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding." [GOC:mah] +comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (sibling term 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283'). +synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" BROAD [] +is_a: GO:0007105 ! cytokinesis, site selection +is_a: GO:0030010 ! establishment of cell polarity + +[Term] +id: GO:0000284 +name: shmoo orientation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. +is_obsolete: true +replaced_by: GO:0000753 + +[Term] +id: GO:0000285 +name: 1-phosphatidylinositol-3-phosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [EC:2.7.1.150] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] +synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] +synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] +synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] +xref: EC:2.7.1.150 +xref: MetaCyc:2.7.1.150-RXN +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0000286 +name: alanine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1] +subset: gosubset_prok +synonym: "AlaDH" RELATED [EC:1.4.1.1] +synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] +synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] +synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] +synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] +synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] +synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] +synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] +xref: EC:1.4.1.1 +xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0000287 +name: magnesium ion binding +namespace: molecular_function +def: "Interacting selectively with magnesium (Mg) ions." [GOC:ai] +subset: gosubset_prok +synonym: "magnesium binding" EXACT [] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0000288 +name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +namespace: biological_process +def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps: poly(A) tail shortening, deadenylylation-dependent decapping, and decay of the transcript body, and that can regulate mRNA stability." [GOC:krc] +synonym: "deadenylation-dependent mRNA decay" EXACT [] +synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] +synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] +synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] +synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] +synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] +synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] +synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000289 +name: nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] +synonym: "3' to 5' mRNA deadenylation" RELATED [] +synonym: "mRNA deadenylation" RELATED [] +synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:0000290 +name: deadenylation-dependent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] +synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] +synonym: "deadenylylation-dependent decapping" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:0000291 +name: nuclear-transcribed mRNA catabolic process, exonucleolytic +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] +synonym: "exonucleolytic degradation of mRNA" EXACT [] +synonym: "mRNA breakdown, exonucleolytic" EXACT [] +synonym: "mRNA degradation, exonucleolytic" EXACT [] +synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000292 +name: RNA fragment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] +subset: gosubset_prok +synonym: "RNA fragment breakdown" EXACT [] +synonym: "RNA fragment catabolism" EXACT [] +synonym: "RNA fragment degradation" EXACT [] +is_a: GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0000293 +name: ferric-chelate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+." [EC:1.16.1.7] +comment: Note that this function was formerly EC:1.6.99.13. +synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] +synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] +synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] +synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] +synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] +synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] +synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] +synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] +xref: EC:1.16.1.7 +xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0000294 +name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay +namespace: biological_process +def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] +synonym: "endonucleolytic mRNA decay" EXACT [] +synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] +synonym: "mRNA catabolic process, endonucleolytic" EXACT [] +synonym: "mRNA catabolism, endonucleolytic" EXACT [] +synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] +synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000295 +name: adenine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870] +is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity + +[Term] +id: GO:0000296 +name: spermine transport +namespace: biological_process +def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of, within or between cells." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015846 ! polyamine transport + +[Term] +id: GO:0000297 +name: spermine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] +is_a: GO:0015203 ! polyamine transmembrane transporter activity + +[Term] +id: GO:0000298 +name: endopolyphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] +synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] +synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] +synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] +synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] +synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] +xref: EC:3.6.1.10 +xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0000299 +name: integral to membrane of membrane fraction +namespace: cellular_component +def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +is_a: GO:0005624 ! membrane fraction + +[Term] +id: GO:0000300 +name: peripheral to membrane of membrane fraction +namespace: cellular_component +def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +is_a: GO:0005624 ! membrane fraction + +[Term] +id: GO:0000301 +name: retrograde transport, vesicle recycling within Golgi +namespace: biological_process +def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] +synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] +is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport + +[Term] +id: GO:0000302 +name: response to reactive oxygen species +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] +subset: gosubset_prok +synonym: "response to active oxygen species" EXACT [] +synonym: "response to AOS" EXACT [] +synonym: "response to reactive oxidative species" EXACT [] +synonym: "response to reactive oxygen intermediate" EXACT [] +synonym: "response to ROI" EXACT [] +synonym: "response to ROS" EXACT [] +is_a: GO:0006979 ! response to oxidative stress + +[Term] +id: GO:0000303 +name: response to superoxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0000305 ! response to oxygen radical + +[Term] +id: GO:0000304 +name: response to singlet oxygen +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:0000305 +name: response to oxygen radical +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] +subset: gosubset_prok +is_a: GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:0000306 +name: extrinsic to vacuolar membrane +namespace: cellular_component +def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0000307 +name: cyclin-dependent protein kinase holoenzyme complex +namespace: cellular_component +def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] +subset: goslim_pir +synonym: "CDK holoenzyme" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000308 +name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex +namespace: cellular_component +def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] +synonym: "CDK holoenzyme" BROAD [] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000309 +name: nicotinamide-nucleotide adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] +subset: gosubset_prok +synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] +synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] +synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] +synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] +synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] +synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] +synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] +synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] +synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] +synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] +synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] +synonym: "NMNAT activity" NARROW [EC:2.7.7.1] +xref: EC:2.7.7.1 +xref: MetaCyc:2.7.7.1-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0000310 +name: xanthine phosphoribosyltransferase activity +namespace: molecular_function +alt_id: GO:0009043 +def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine." [EC:2.4.2.22, GOC:clt] +subset: gosubset_prok +synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] +synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] +synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] +synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] +synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] +synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] +synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] +synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] +xref: EC:2.4.2.22 +xref: MetaCyc:XANPRIBOSYLTRAN-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0000311 +name: plastid large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] +is_a: GO:0000315 ! organellar large ribosomal subunit +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009547 ! plastid ribosome + +[Term] +id: GO:0000312 +name: plastid small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] +is_a: GO:0000314 ! organellar small ribosomal subunit +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009547 ! plastid ribosome + +[Term] +id: GO:0000313 +name: organellar ribosome +namespace: cellular_component +def: "A ribosome contained within a subcellular organelle." [GOC:mcc] +is_a: GO:0005840 ! ribosome + +[Term] +id: GO:0000314 +name: organellar small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] +is_a: GO:0015935 ! small ribosomal subunit +relationship: part_of GO:0000313 ! organellar ribosome + +[Term] +id: GO:0000315 +name: organellar large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] +is_a: GO:0015934 ! large ribosomal subunit +relationship: part_of GO:0000313 ! organellar ribosome + +[Term] +id: GO:0000316 +name: sulfite transport +namespace: biological_process +def: "The directed movement of sulfite into, out of, within or between cells." [GOC:krc] +synonym: "sulphite transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0000317 +name: methionine-S-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide. Thioredoxin disulfide is the oxidized form of thioredoxin. No reaction on oxidized methionine in peptide linkage." [PMID:11169920] +subset: gosubset_prok +synonym: "methionine sulfoxide reductase activity" EXACT [] +xref: MetaCyc:METHIONINE-S-OXIDE-REDUCTASE-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0000318 +name: protein-methionine-R-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.-, PMID:11929995] +subset: gosubset_prok +synonym: "(protein) methionine-R-sulfoxide reductase activity" EXACT [] +xref: EC:1.8.4.- +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0000319 +name: sulfite transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] +synonym: "sulphite transporter activity" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0000320 +name: re-entry into mitotic cell cycle +namespace: biological_process +def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0000321 +name: re-entry into mitotic cell cycle after pheromone arrest +namespace: biological_process +def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449] +synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" NARROW [] +is_a: GO:0000320 ! re-entry into mitotic cell cycle +is_a: GO:0000754 ! adaptation to pheromone during conjugation with cellular fusion + +[Term] +id: GO:0000322 +name: storage vacuole +namespace: cellular_component +def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000323 +name: lytic vacuole +namespace: cellular_component +def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000324 +name: fungal-type vacuole +namespace: cellular_component +def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] +synonym: "vacuole (sensu Fungi)" EXACT [] +synonym: "vacuole, cell cycle-correlated morphology" EXACT [] +is_a: GO:0000322 ! storage vacuole +is_a: GO:0000323 ! lytic vacuole + +[Term] +id: GO:0000325 +name: plant-type vacuole +namespace: cellular_component +def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase." [GOC:mtg_sensu, ISBN:0815316208] +synonym: "vacuole (sensu Magnoliophyta)" RELATED [] +synonym: "vacuole, cell cycle-independent morphology" EXACT [] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000326 +name: protein storage vacuole +namespace: cellular_component +def: "A compound organelle of plants where there is a lytic vacuole within a storage vacuole." [PMID:11739409] +is_a: GO:0000322 ! storage vacuole +is_a: GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0000327 +name: lytic vacuole within protein storage vacuole +namespace: cellular_component +def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] +is_a: GO:0000323 ! lytic vacuole +is_a: GO:0000326 ! protein storage vacuole + +[Term] +id: GO:0000328 +name: fungal-type vacuole lumen +namespace: cellular_component +def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase." [GOC:krc, GOC:mtg_sensu] +synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] +synonym: "vacuolar lumen (sensu Fungi)" RELATED [] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0000324 ! fungal-type vacuole + +[Term] +id: GO:0000329 +name: fungal-type vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell." [GOC:krc, GOC:mtg_sensu] +synonym: "fungal-type vacuolar membrane" RELATED [] +synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] +synonym: "vacuolar membrane (sensu Fungi)" EXACT [] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0000324 ! fungal-type vacuole + +[Term] +id: GO:0000330 +name: plant-type vacuole lumen +namespace: cellular_component +def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase." [GOC:krc, GOC:mtg_sensu] +synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] +synonym: "vacuolar lumen (sensu Magnoliophyta)" EXACT [] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0000331 +name: contractile vacuole +namespace: cellular_component +def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:10503189] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000332 +name: template for synthesis of G-rich strand of telomere DNA activity +namespace: molecular_function +def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] +synonym: "telomerase RNA" EXACT [] +synonym: "telomerase, template" EXACT [] +is_a: GO:0000497 ! base pairing with DNA +relationship: part_of GO:0003720 ! telomerase activity + +[Term] +id: GO:0000333 +name: telomerase catalytic core complex +namespace: cellular_component +def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619] +is_a: GO:0005697 ! telomerase holoenzyme complex + +[Term] +id: GO:0000334 +name: 3-hydroxyanthranilate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde." [EC:1.13.11.6] +subset: gosubset_prok +synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] +synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] +synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] +synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] +synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] +synonym: "3HAO" RELATED [EC:1.13.11.6] +xref: EC:1.13.11.6 +xref: MetaCyc:1.13.11.6-RXN +xref: Reactome:23302 +xref: UM-BBD_enzymeID:e0633 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0000335 +name: negative regulation of transposition, DNA-mediated +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] +subset: gosubset_prok +synonym: "down regulation of DNA transposition" EXACT [] +synonym: "down-regulation of DNA transposition" EXACT [] +synonym: "downregulation of DNA transposition" EXACT [] +synonym: "inhibition of DNA transposition" NARROW [] +synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] +is_a: GO:0000337 ! regulation of transposition, DNA-mediated +is_a: GO:0010529 ! negative regulation of transposition +relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0000336 +name: positive regulation of transposition, DNA-mediated +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] +subset: gosubset_prok +synonym: "activation of DNA transposition" NARROW [] +synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] +synonym: "stimulation of DNA transposition" NARROW [] +synonym: "up regulation of DNA transposition" EXACT [] +synonym: "up-regulation of DNA transposition" EXACT [] +synonym: "upregulation of DNA transposition" EXACT [] +is_a: GO:0000337 ! regulation of transposition, DNA-mediated +is_a: GO:0010530 ! positive regulation of transposition +relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0000337 +name: regulation of transposition, DNA-mediated +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] +subset: gosubset_prok +synonym: "regulation of DNA transposition" EXACT [GOC:dph] +is_a: GO:0010528 ! regulation of transposition +relationship: regulates GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0000338 +name: protein deneddylation +namespace: biological_process +def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0000339 +name: RNA cap binding +namespace: molecular_function +def: "Interacting selectively with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule." [GOC:krc] +synonym: "binding to mRNA cap" NARROW [] +synonym: "mRNA cap binding" NARROW [] +synonym: "snRNA cap binding" NARROW [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0000340 +name: RNA 7-methylguanosine cap binding +namespace: molecular_function +def: "Interacting selectively with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] +synonym: "RNA m7G cap binding" EXACT [] +is_a: GO:0000339 ! RNA cap binding + +[Term] +id: GO:0000341 +name: RNA trimethylguanosine cap binding +namespace: molecular_function +def: "Interacting selectively with the trimethylguanosine (m(3)(2,2,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] +synonym: "RNA m2,2,7G cap binding" EXACT [] +is_a: GO:0000339 ! RNA cap binding + +[Term] +id: GO:0000342 +name: RNA cap 4 binding +namespace: molecular_function +def: "Interacting selectively with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] +is_a: GO:0000339 ! RNA cap binding + +[Term] +id: GO:0000343 +name: plastid-encoded plastid RNA polymerase complex A +namespace: cellular_component +def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] +synonym: "PEP-A" EXACT [] +is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex + +[Term] +id: GO:0000344 +name: plastid-encoded plastid RNA polymerase complex B +namespace: cellular_component +def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] +synonym: "PEP-B" EXACT [] +is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex + +[Term] +id: GO:0000345 +name: cytosolic DNA-directed RNA polymerase complex +namespace: cellular_component +def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] +subset: gosubset_prok +synonym: "cytosolic DNA-directed RNA polymerase complex (sensu Bacteria)" EXACT [] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0000346 +name: transcription export complex +namespace: cellular_component +def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] +subset: goslim_pir +synonym: "TREX complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000347 +name: THO complex +namespace: cellular_component +def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000348 +name: nuclear mRNA branch site recognition +namespace: biological_process +alt_id: GO:0000370 +alt_id: GO:0000371 +def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). +synonym: "spliceosomal A complex biosynthesis" NARROW [] +synonym: "spliceosomal A complex formation" NARROW [] +synonym: "spliceosomal B complex biosynthesis" NARROW [] +synonym: "spliceosomal B complex formation" NARROW [] +synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] +synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosome assembly + +[Term] +id: GO:0000349 +name: generation of catalytic spliceosome for first transesterification step +namespace: biological_process +alt_id: GO:0000356 +alt_id: GO:0000357 +def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). +synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] +synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] +synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] +synonym: "spliceosomal A2-2 complex formation" NARROW [] +synonym: "spliceosomal C1 complex biosynthesis" NARROW [] +synonym: "spliceosomal C1 complex formation" NARROW [] +synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] +synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation + +[Term] +id: GO:0000350 +name: generation of catalytic spliceosome for second transesterification step +namespace: biological_process +alt_id: GO:0000358 +alt_id: GO:0000359 +def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). +synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] +synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] +synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] +synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] +synonym: "formation of spliceosomal A2-2 complex" NARROW [] +synonym: "formation of spliceosomal C1 complex" NARROW [] +synonym: "lariat formation, 5'-splice site cleavage" RELATED [] +synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] +synonym: "spliceosomal A2-3 complex formation" NARROW [] +synonym: "spliceosomal C2 complex biosynthesis" NARROW [] +synonym: "spliceosomal C2 complex formation" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation + +[Term] +id: GO:0000352 +name: trans assembly of SL-containing precatalytic spliceosome +namespace: biological_process +def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] +synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosome assembly +relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition + +[Term] +id: GO:0000353 +name: formation of quadruple SL/U4/U5/U6 snRNP +namespace: biological_process +def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] +comment: Note that this step is analogous to 5' splice site selection in cis-splicing. +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition + +[Term] +id: GO:0000354 +name: cis assembly of pre-catalytic spliceosome +namespace: biological_process +alt_id: GO:0000360 +alt_id: GO:0000361 +def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] +comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). +synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] +synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] +synonym: "formation of spliceosomal A2-1 complex" NARROW [] +synonym: "formation of spliceosomal B1 complex" NARROW [] +synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] +synonym: "spliceosomal A2-1 complex formation" NARROW [] +synonym: "spliceosomal B1 complex biosynthesis" NARROW [] +synonym: "spliceosomal B1 complex formation" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosome assembly +relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome + +[Term] +id: GO:0000362 +name: first U2-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "lariat formation, 5'-splice site cleavage" BROAD [] +is_obsolete: true +replaced_by: GO:0000384 + +[Term] +id: GO:0000363 +name: first U12-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "lariat formation, 5'-splice site cleavage" BROAD [] +is_obsolete: true +replaced_by: GO:0000384 + +[Term] +id: GO:0000364 +name: second U2-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +is_obsolete: true +replaced_by: GO:0000386 + +[Term] +id: GO:0000365 +name: nuclear mRNA trans splicing, via spliceosome +namespace: biological_process +def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897] +synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] +is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000366 +name: intergenic nuclear mRNA trans splicing +namespace: biological_process +def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] +is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome +is_a: GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000367 +name: second U12-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +is_obsolete: true +replaced_by: GO:0000386 + +[Term] +id: GO:0000372 +name: Group I intron splicing +namespace: biological_process +def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] +comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). +subset: gosubset_prok +synonym: "mRNA splicing" NARROW [] +is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile + +[Term] +id: GO:0000373 +name: Group II intron splicing +namespace: biological_process +def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] +comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. +subset: gosubset_prok +synonym: "mRNA splicing" NARROW [] +is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile + +[Term] +id: GO:0000374 +name: Group III intron splicing +namespace: biological_process +def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] +comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. +subset: gosubset_prok +synonym: "mRNA splicing" NARROW [] +is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile + +[Term] +id: GO:0000375 +name: RNA splicing, via transesterification reactions +namespace: biological_process +def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] +subset: gosubset_prok +is_a: GO:0008380 ! RNA splicing + +[Term] +id: GO:0000376 +name: RNA splicing, via transesterification reactions with guanosine as nucleophile +namespace: biological_process +def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] +subset: gosubset_prok +is_a: GO:0000375 ! RNA splicing, via transesterification reactions + +[Term] +id: GO:0000377 +name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile +namespace: biological_process +def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] +subset: gosubset_prok +synonym: "lariat RNA biosynthesis" RELATED [] +synonym: "lariat RNA formation" RELATED [] +is_a: GO:0000375 ! RNA splicing, via transesterification reactions + +[Term] +id: GO:0000378 +name: RNA exon ligation +namespace: biological_process +def: "The process of joining two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] +comment: Note that this is not a part of spliceosomal RNA splicing. +subset: gosubset_prok +is_a: GO:0016070 ! RNA metabolic process +relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation + +[Term] +id: GO:0000379 +name: tRNA-type intron splice site recognition and cleavage +namespace: biological_process +def: "The process by which the tertiary structure of a tRNA type intron is recognized, and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] +subset: gosubset_prok +is_a: GO:0006396 ! RNA processing +relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation + +[Term] +id: GO:0000380 +name: alternative nuclear mRNA splicing, via spliceosome +namespace: biological_process +def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] +comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. +synonym: "splice site selection" BROAD [] +is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000381 +name: regulation of alternative nuclear mRNA splicing, via spliceosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] +synonym: "splice site selection" BROAD [] +is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome +relationship: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000384 +name: first spliceosomal transesterification activity +namespace: molecular_function +def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] +synonym: "lariat formation, 5'-splice site cleavage" NARROW [] +is_a: GO:0031202 ! RNA splicing factor activity, transesterification mechanism + +[Term] +id: GO:0000386 +name: second spliceosomal transesterification activity +namespace: molecular_function +def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +synonym: "lariat formation, 5'-splice site cleavage" NARROW [] +is_a: GO:0031202 ! RNA splicing factor activity, transesterification mechanism + +[Term] +id: GO:0000387 +name: spliceosomal snRNP biogenesis +namespace: biological_process +def: "The formation and assembly from one or more snRNA and multiple protein components of a ribonucleoprotein complex that in involved in formation of the spliceosome." [GOC:krc, ISBN:0879695897] +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis and assembly +relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000388 +name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) +namespace: biological_process +alt_id: GO:0000396 +alt_id: GO:0000397 +def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +synonym: "spliceosomal A1 complex biosynthesis" NARROW [] +synonym: "spliceosomal A1 complex formation" NARROW [] +synonym: "spliceosomal B2 complex biosynthesis" NARROW [] +synonym: "spliceosomal B2 complex formation" NARROW [] +synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] +synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation + +[Term] +id: GO:0000389 +name: nuclear mRNA 3'-splice site recognition +namespace: biological_process +alt_id: GO:0000382 +alt_id: GO:0000383 +def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] +synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] +synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] +is_a: GO:0006376 ! mRNA splice site selection + +[Term] +id: GO:0000390 +name: spliceosome disassembly +namespace: biological_process +alt_id: GO:0000391 +alt_id: GO:0000392 +def: "Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] +synonym: "spliceosome complex disassembly" EXACT [] +synonym: "U12-type spliceosome disassembly" NARROW [] +synonym: "U2-type spliceosome disassembly" NARROW [] +is_a: GO:0032988 ! ribonucleoprotein complex disassembly +relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000393 +name: spliceosomal conformational changes to generate catalytic conformation +namespace: biological_process +def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0000394 +name: RNA splicing, via endonucleolytic cleavage and ligation +namespace: biological_process +def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] +comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. +subset: gosubset_prok +synonym: "mRNA splicing" BROAD [] +is_a: GO:0008380 ! RNA splicing + +[Term] +id: GO:0000395 +name: nuclear mRNA 5'-splice site recognition +namespace: biological_process +alt_id: GO:0000368 +alt_id: GO:0000369 +def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). +synonym: "nuclear mRNA 5' splice site recognition" EXACT [] +synonym: "spliceosomal CC complex biosynthesis" NARROW [] +synonym: "spliceosomal CC complex formation" NARROW [] +synonym: "spliceosomal commitment complex biosynthesis" NARROW [] +synonym: "spliceosomal commitment complex formation" NARROW [] +synonym: "spliceosomal E complex biosynthesis" NARROW [] +synonym: "spliceosomal E complex formation" NARROW [] +synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] +synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] +synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] +synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] +is_a: GO:0006376 ! mRNA splice site selection +relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome + +[Term] +id: GO:0000398 +name: nuclear mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0006374 +alt_id: GO:0006375 +def: "The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0879695897] +comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. +synonym: "mRNA splicing" BROAD [] +synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] +synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "pre-mRNA splicing" BROAD [] +synonym: "splicing AT-AC intron" RELATED [] +synonym: "splicing GT-AG intron" RELATED [] +xref: Reactome:212002 +xref: Reactome:221766 +xref: Reactome:238383 +xref: Reactome:244938 +xref: Reactome:249819 +xref: Reactome:255735 +xref: Reactome:259129 +xref: Reactome:262486 +xref: Reactome:274165 +xref: Reactome:280638 +xref: Reactome:286656 +xref: Reactome:288338 +xref: Reactome:291782 +xref: Reactome:293761 +xref: Reactome:72172 +is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0000399 +name: cellular bud neck septin structure +namespace: cellular_component +def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] +is_a: GO:0032155 ! cell division site part +relationship: part_of GO:0005935 ! cellular bud neck + +[Term] +id: GO:0000400 +name: four-way junction DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] +synonym: "forked DNA binding" BROAD [] +synonym: "Holliday junction binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000401 +name: open form four-way junction DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] +synonym: "open form Holliday junction binding" EXACT [] +is_a: GO:0000400 ! four-way junction DNA binding + +[Term] +id: GO:0000402 +name: crossed form four-way junction DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] +synonym: "crossed form Holliday junction binding" EXACT [] +is_a: GO:0000400 ! four-way junction DNA binding + +[Term] +id: GO:0000403 +name: Y-form DNA binding +namespace: molecular_function +def: "Interacting selectively with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] +synonym: "forked DNA binding" BROAD [] +synonym: "slayed Y-form DNA binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000404 +name: loop DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] +is_a: GO:0000217 ! DNA secondary structure binding +is_a: GO:0032135 ! DNA insertion or deletion binding + +[Term] +id: GO:0000405 +name: bubble DNA binding +namespace: molecular_function +def: "Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, PMID:16781730] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000406 +name: double-strand/single-strand DNA junction binding +namespace: molecular_function +def: "Interacting selectively with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000407 +name: pre-autophagosomal structure +namespace: cellular_component +def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] +synonym: "PAS" EXACT [] +synonym: "perivacuolar space" NARROW [] +synonym: "phagophore assembly site" RELATED [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000408 +name: EKC/KEOPS protein complex +namespace: cellular_component +def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308] +synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT [] +synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000409 +name: regulation of transcription by galactose +namespace: biological_process +def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0045990 ! regulation of transcription by carbon catabolites + +[Term] +id: GO:0000410 +name: negative regulation of transcription by galactose +namespace: biological_process +def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah] +synonym: "down regulation of transcription by galactose" EXACT [] +synonym: "down-regulation of transcription by galactose" EXACT [] +synonym: "downregulation of transcription by galactose" EXACT [] +synonym: "inhibition of transcription by galactose" NARROW [] +is_a: GO:0000409 ! regulation of transcription by galactose +is_a: GO:0045013 ! negative regulation of transcription by carbon catabolites + +[Term] +id: GO:0000411 +name: positive regulation of transcription by galactose +namespace: biological_process +def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] +synonym: "activation of transcription by galactose" NARROW [] +synonym: "stimulation of transcription by galactose" NARROW [] +synonym: "up regulation of transcription by galactose" EXACT [] +synonym: "up-regulation of transcription by galactose" EXACT [] +synonym: "upregulation of transcription by galactose" EXACT [] +is_a: GO:0000409 ! regulation of transcription by galactose +is_a: GO:0045991 ! positive regulation of transcription by carbon catabolites + +[Term] +id: GO:0000412 +name: histone peptidyl-prolyl isomerization +namespace: biological_process +def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] +synonym: "histone proline isomerization" EXACT [] +is_a: GO:0000413 ! protein peptidyl-prolyl isomerization +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0000413 +name: protein peptidyl-prolyl isomerization +namespace: biological_process +def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] +synonym: "protein proline isomerization" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0000414 +name: regulation of histone H3-K36 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0010452 ! histone H3-K36 methylation + +[Term] +id: GO:0000415 +name: negative regulation of histone H3-K36 methylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] +synonym: "down regulation of histone H3-K36 methylation" EXACT [] +synonym: "down-regulation of histone H3-K36 methylation" EXACT [] +synonym: "downregulation of histone H3-K36 methylation" EXACT [] +synonym: "inhibition of histone H3-K36 methylation" NARROW [] +is_a: GO:0000414 ! regulation of histone H3-K36 methylation +is_a: GO:0031061 ! negative regulation of histone methylation +relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation + +[Term] +id: GO:0000416 +name: positive regulation of histone H3-K36 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] +synonym: "activation of histone H3-K36 methylation" NARROW [] +synonym: "stimulation of histone H3-K36 methylation" NARROW [] +synonym: "up regulation of histone H3-K36 methylation" EXACT [] +synonym: "up-regulation of histone H3-K36 methylation" EXACT [] +synonym: "upregulation of histone H3-K36 methylation" EXACT [] +is_a: GO:0000414 ! regulation of histone H3-K36 methylation +is_a: GO:0031062 ! positive regulation of histone methylation +relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation + +[Term] +id: GO:0000417 +name: HIR complex +namespace: cellular_component +def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] +is_a: GO:0005678 ! chromatin assembly complex + +[Term] +id: GO:0000418 +name: DNA-directed RNA polymerase IV complex +namespace: cellular_component +def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The IVa and IVb complexes contain different forms of the largest subunit. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984] +is_a: GO:0044451 ! nucleoplasm part +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex + +[Term] +id: GO:0000419 +name: DNA-directed RNA polymerase IVb complex +namespace: cellular_component +def: "RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984] +is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex + +[Term] +id: GO:0000420 +name: DNA-directed RNA polymerase IVa complex +namespace: cellular_component +def: "RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984] +is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex + +[Term] +id: GO:0000421 +name: autophagic vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete] +synonym: "autophagosome membrane" EXACT [] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0005776 ! autophagic vacuole + +[Term] +id: GO:0000422 +name: mitochondrion degradation +namespace: biological_process +def: "The process by which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions, autophagy of mitochondria." [PMID:15798367] +synonym: "mitophagy" EXACT [] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0000423 +name: macromitophagy +namespace: biological_process +def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367] +is_a: GO:0000422 ! mitochondrion degradation +is_a: GO:0016236 ! macroautophagy + +[Term] +id: GO:0000424 +name: micromitophagy +namespace: biological_process +def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367] +is_a: GO:0000422 ! mitochondrion degradation +is_a: GO:0016237 ! microautophagy + +[Term] +id: GO:0000425 +name: macropexophagy +namespace: biological_process +def: "Degradation of a peroxisome by macropexophagy." [PMID:12914914, PMID:16973210] +is_a: GO:0016236 ! macroautophagy +is_a: GO:0030242 ! peroxisome degradation + +[Term] +id: GO:0000426 +name: micropexophagy +namespace: biological_process +def: "Degradation of a peroxisome by micropexophagy." [PMID:12914914, PMID:16973210] +is_a: GO:0016237 ! microautophagy +is_a: GO:0030242 ! peroxisome degradation + +[Term] +id: GO:0000427 +name: plastid-encoded plastid RNA polymerase complex +namespace: cellular_component +def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0000428 +name: DNA-directed RNA polymerase complex +namespace: cellular_component +def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] +is_a: GO:0030880 ! RNA polymerase complex + +[Term] +id: GO:0000429 +name: regulation of transcription from RNA polymerase II promoter by carbon catabolites +namespace: biological_process +def: "Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0045990 ! regulation of transcription by carbon catabolites + +[Term] +id: GO:0000430 +name: regulation of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites +is_a: GO:0046015 ! regulation of transcription by glucose + +[Term] +id: GO:0000431 +name: regulation of transcription from RNA polymerase II promoter by galactose +namespace: biological_process +def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +is_a: GO:0000409 ! regulation of transcription by galactose +is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites + +[Term] +id: GO:0000432 +name: positive regulation of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] +synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose +is_a: GO:0000436 ! positive regulation of transcription from RNA polymerase II promoter by carbon catabolites +is_a: GO:0046016 ! positive regulation of transcription by glucose + +[Term] +id: GO:0000433 +name: negative regulation of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] +is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose +is_a: GO:0000437 ! negative regulation of transcription from RNA polymerase II promoter by carbon catabolites +is_a: GO:0045014 ! negative regulation of transcription by glucose + +[Term] +id: GO:0000434 +name: negative regulation of transcription from RNA polymerase II promoter by galactose +namespace: biological_process +def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] +is_a: GO:0000410 ! negative regulation of transcription by galactose +is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose +is_a: GO:0000437 ! negative regulation of transcription from RNA polymerase II promoter by carbon catabolites + +[Term] +id: GO:0000435 +name: positive regulation of transcription from RNA polymerase II promoter by galactose +namespace: biological_process +def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] +synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +is_a: GO:0000411 ! positive regulation of transcription by galactose +is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose +is_a: GO:0000436 ! positive regulation of transcription from RNA polymerase II promoter by carbon catabolites + +[Term] +id: GO:0000436 +name: positive regulation of transcription from RNA polymerase II promoter by carbon catabolites +namespace: biological_process +def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "activation of transcription from RNA polymerase II promoter by carbon catabolites" NARROW [] +synonym: "stimulation of transcription from RNA polymerase II promoter by carbon catabolites" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] +is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0000437 +name: negative regulation of transcription from RNA polymerase II promoter by carbon catabolites +namespace: biological_process +def: "Any process involving carbon catabolites that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "down regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by carbon catabolites" NARROW [] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites + +[Term] +id: GO:0000438 +name: core TFIIH complex portion of holo TFIIH complex +namespace: cellular_component +def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] +is_a: GO:0000439 ! core TFIIH complex +is_a: GO:0044451 ! nucleoplasm part +relationship: part_of GO:0000443 ! SSL2-core TFIIH complex portion of holo TFIIH complex + +[Term] +id: GO:0000439 +name: core TFIIH complex +namespace: cellular_component +def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of XPD, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015] +is_a: GO:0043234 ! protein complex +relationship: part_of GO:0000441 ! SSL2-core TFIIH complex + +[Term] +id: GO:0000440 +name: core TFIIH complex portion of NEF3 complex +namespace: cellular_component +def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] +is_a: GO:0000439 ! core TFIIH complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0000442 ! SSL2-core TFIIH complex portion of NEF3 complex + +[Term] +id: GO:0000441 +name: SSL2-core TFIIH complex +namespace: cellular_component +def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of XPD, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] +subset: goslim_pir +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0000442 +name: SSL2-core TFIIH complex portion of NEF3 complex +namespace: cellular_component +def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of XPD, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] +is_a: GO:0000441 ! SSL2-core TFIIH complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex + +[Term] +id: GO:0000443 +name: SSL2-core TFIIH complex portion of holo TFIIH complex +namespace: cellular_component +def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of XPD, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] +is_a: GO:0000441 ! SSL2-core TFIIH complex +is_a: GO:0044451 ! nucleoplasm part +relationship: part_of GO:0005675 ! holo TFIIH complex + +[Term] +id: GO:0000444 +name: MIS12/MIND type complex +namespace: cellular_component +def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] +synonym: "Mis12 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000777 ! condensed chromosome kinetochore + +[Term] +id: GO:0000445 +name: THO complex part of transcription export complex +namespace: cellular_component +def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] +synonym: "THO complex part of TREX complex" EXACT [] +is_a: GO:0000347 ! THO complex +relationship: part_of GO:0000346 ! transcription export complex + +[Term] +id: GO:0000446 +name: nucleoplasmic THO complex +namespace: cellular_component +def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] +is_a: GO:0000347 ! THO complex +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0000447 +name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +synonym: "endonucleolytic cleavage at A2" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000448 +name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +alt_id: GO:0000490 +def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +synonym: "cleavage at C2" RELATED [] +synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000449 +name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing + +[Term] +id: GO:0000450 +name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing + +[Term] +id: GO:0000451 +name: rRNA 2'-O-methylation +namespace: biological_process +def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] +is_a: GO:0031167 ! rRNA methylation + +[Term] +id: GO:0000452 +name: snoRNA guided rRNA 2'-O-methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] +is_a: GO:0000451 ! rRNA 2'-O-methylation + +[Term] +id: GO:0000453 +name: enzyme-directed rRNA 2'-O-methylation +namespace: biological_process +def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] +is_a: GO:0000451 ! rRNA 2'-O-methylation + +[Term] +id: GO:0000454 +name: snoRNA guided rRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] +is_a: GO:0031118 ! rRNA pseudouridine synthesis + +[Term] +id: GO:0000455 +name: enzyme-directed rRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] +is_a: GO:0031118 ! rRNA pseudouridine synthesis + +[Term] +id: GO:0000456 +name: dimethylation during SSU-rRNA biogenesis +namespace: biological_process +def: "Dimethyation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] +is_a: GO:0031167 ! rRNA methylation + +[Term] +id: GO:0000457 +name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +namespace: biological_process +def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) +relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) + +[Term] +id: GO:0000458 +name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +namespace: biological_process +def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) + +[Term] +id: GO:0000459 +name: exonucleolytic trimming during rRNA processing +namespace: biological_process +def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] +is_a: GO:0000469 ! cleavages during rRNA processing + +[Term] +id: GO:0000460 +name: maturation of 5.8S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000461 +name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] +synonym: "endonucleolytic cleavage at site D" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +is_a: GO:0031125 ! rRNA 3'-end processing +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000462 +name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0000463 +name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0000464 +name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] +synonym: "endonucleolytic cleavage at A3" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000465 +name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] +is_a: GO:0000459 ! exonucleolytic trimming during rRNA processing +is_a: GO:0000967 ! rRNA 5'-end processing +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000466 +name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +is_a: GO:0000460 ! maturation of 5.8S rRNA + +[Term] +id: GO:0000467 +name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] +is_a: GO:0000459 ! exonucleolytic trimming during rRNA processing +is_a: GO:0031125 ! rRNA 3'-end processing +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000468 +name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] +synonym: "processing at B2" NARROW [] +is_a: GO:0031125 ! rRNA 3'-end processing +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000469 +name: cleavages during rRNA processing +namespace: biological_process +def: "Any cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000470 +name: maturation of LSU-rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000471 +name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000472 +name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] +synonym: "endonucleolytic cleavage at A1" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +is_a: GO:0000967 ! rRNA 5'-end processing +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000473 +name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0000474 +name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0000475 +name: maturation of 2S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000476 +name: maturation of 4.5S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000477 +name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +synonym: "processing at C1" NARROW [] +is_a: GO:0000469 ! cleavages during rRNA processing +is_a: GO:0000967 ! rRNA 5'-end processing +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000478 +name: endonucleolytic cleavages during rRNA processing +namespace: biological_process +def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] +is_a: GO:0000469 ! cleavages during rRNA processing + +[Term] +id: GO:0000479 +name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] +is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing + +[Term] +id: GO:0000480 +name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] +synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] +synonym: "endonucleolytic cleavage at A0" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000481 +name: maturation of 5S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000482 +name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000481 ! maturation of 5S rRNA + +[Term] +id: GO:0000483 +name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing + +[Term] +id: GO:0000484 +name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) + +[Term] +id: GO:0000485 +name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] +is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000475 ! maturation of 2S rRNA + +[Term] +id: GO:0000486 +name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] +is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000475 ! maturation of 2S rRNA +relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) + +[Term] +id: GO:0000487 +name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000460 ! maturation of 5.8S rRNA + +[Term] +id: GO:0000488 +name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0000489 +name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0000491 +name: snoRNP assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] +synonym: "small nucleolar ribonucleoprotein complex assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:0000492 +name: box C/D snoRNP assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] +synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] +is_a: GO:0000491 ! snoRNP assembly + +[Term] +id: GO:0000493 +name: box H/ACA snoRNP assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] +synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] +is_a: GO:0000491 ! snoRNP assembly + +[Term] +id: GO:0000494 +name: box C/D snoRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc] +synonym: "box C/D snoRNA 3' end processing" EXACT [] +is_a: GO:0031126 ! snoRNA 3'-end processing +is_a: GO:0034963 ! box C/D snoRNA processing + +[Term] +id: GO:0000495 +name: box H/ACA snoRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] +synonym: "box H/ACA snoRNA 3' end processing" EXACT [] +is_a: GO:0031126 ! snoRNA 3'-end processing +is_a: GO:0034964 ! box H/ACA snoRNA processing + +[Term] +id: GO:0000496 +name: base pairing +namespace: molecular_function +def: "Interacting selectively with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0000497 +name: base pairing with DNA +namespace: molecular_function +def: "Interacting selectively with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0000496 ! base pairing +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0000498 +name: base pairing with RNA +namespace: molecular_function +def: "Interacting selectively with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0000496 ! base pairing +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0000499 +name: base pairing with mRNA +namespace: molecular_function +def: "Interacting selectively with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0000498 ! base pairing with RNA + +[Term] +id: GO:0000500 +name: RNA polymerase I upstream activating factor complex +namespace: cellular_component +def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] +synonym: "RNA polymerase I upstream activation factor complex" EXACT [] +synonym: "UAF" EXACT [] +is_a: GO:0000120 ! RNA polymerase I transcription factor complex + +[Term] +id: GO:0000501 +name: flocculation via cell wall protein-carbohydrate interaction +namespace: biological_process +def: "Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible." [DOI:10.1016/S0963-9969(99)00021-6, GOC:sgd_curators] +subset: gosubset_prok +synonym: "flocculation (sensu Saccharomyces)" NARROW [] +is_a: GO:0000128 ! flocculation + +[Term] +id: GO:0000502 +name: proteasome complex +namespace: cellular_component +def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb] +subset: goslim_pir +synonym: "26S proteasome" NARROW [] +synonym: "proteasome complex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0000504 +name: proteasome regulatory particle (sensu Bacteria) +namespace: cellular_component +def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] +comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. +synonym: "26S proteasome" NARROW [] +is_obsolete: true + +[Term] +id: GO:0000506 +name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] +comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. +synonym: "GPI-GlcNAc transferase complex" EXACT [] +synonym: "GPI-GnT complex" EXACT [] +synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0000508 +name: Rpd3L complex +namespace: cellular_component +def: "A multisubunit histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p." [GOC:rb, PMID:16286008, PMID:16314178] +synonym: "Rpd3C(L)" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0000509 +name: Rpd3S complex +namespace: cellular_component +def: "A multisubunit histone deacetylase complex that is involved in intragenic transcription repression through histone deacetylation. In S. cerevisiae, this complex consists of Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3." [GOC:rb, PMID:16286007, PMID:16286008] +synonym: "Rpd3C(S)" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0000578 +name: embryonic axis specification +namespace: biological_process +def: "Axis specification in the embryo." [GOC:go_curators] +synonym: "embryonic axis determination" EXACT [] +is_a: GO:0009798 ! axis specification +is_a: GO:0009880 ! embryonic pattern specification + +[Term] +id: GO:0000700 +name: mismatch base pair DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0000701 +name: purine-specific mismatch base pair DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] +synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] +xref: EC:3.2.2.- +is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity + +[Term] +id: GO:0000702 +name: oxidized base lesion DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] +subset: gosubset_prok +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0000703 +name: oxidized pyrimidine base lesion DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0019004 +def: "Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:elh, PMID:11554296] +subset: gosubset_prok +synonym: "bifunctional DNA glycosylase" BROAD [] +synonym: "DNA glycosylase/AP-lyase" BROAD [] +synonym: "DNA glycosylase/beta-lyase" BROAD [] +synonym: "endodeoxyribonuclease III" RELATED [] +synonym: "endonuclease III" RELATED [] +synonym: "endonuclease VIII activity" RELATED [] +synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] +xref: Reactome:25087 +is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity +is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0000704 +name: pyrimidine dimer DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] +is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity +is_a: GO:0004520 ! endodeoxyribonuclease activity +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0000705 +name: achiasmate meiosis I +namespace: biological_process +def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] +is_a: GO:0007127 ! meiosis I + +[Term] +id: GO:0000706 +name: meiotic DNA double-strand break processing +namespace: biological_process +def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] +is_a: GO:0000729 ! DNA double-strand break processing +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0000707 +name: meiotic DNA recombinase assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] +is_a: GO:0000730 ! DNA recombinase assembly +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0000708 +name: meiotic strand invasion +namespace: biological_process +def: "The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] +synonym: "meiotic D-loop biosynthesis" RELATED [] +synonym: "meiotic D-loop formation" RELATED [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0042148 ! strand invasion +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0000709 +name: meiotic joint molecule formation +namespace: biological_process +def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0000710 +name: meiotic mismatch repair +namespace: biological_process +def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] +is_a: GO:0006298 ! mismatch repair +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0000711 +name: meiotic DNA repair synthesis +namespace: biological_process +def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] +is_a: GO:0000731 ! DNA synthesis during DNA repair +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0000712 +name: resolution of meiotic joint molecules as recombinants +namespace: biological_process +def: "The cleavage and rejoining of Holliday junctions formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] +synonym: "crossover biosynthesis" NARROW [] +synonym: "crossover formation" NARROW [] +synonym: "formation of chiasmata" NARROW [] +synonym: "homologous chromosome separation at meiosis I" EXACT [] +synonym: "meiotic homologous chromosome separation" RELATED [] +is_a: GO:0051307 ! meiotic chromosome separation +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0000713 +name: meiotic heteroduplex formation +namespace: biological_process +def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0030491 ! heteroduplex formation +relationship: part_of GO:0006310 ! DNA recombination +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0000714 +name: meiotic strand displacement +namespace: biological_process +def: "The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] +is_a: GO:0000732 ! strand displacement +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0000715 +name: nucleotide-excision repair, DNA damage recognition +namespace: biological_process +def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] +subset: gosubset_prok +synonym: "pyrimidine-dimer repair, DNA damage recognition" NARROW [] +xref: Reactome:211942 +xref: Reactome:221707 +xref: Reactome:230290 +xref: Reactome:238329 +xref: Reactome:244887 +xref: Reactome:249779 +xref: Reactome:252522 +xref: Reactome:255701 +xref: Reactome:259092 +xref: Reactome:262453 +xref: Reactome:265289 +xref: Reactome:268410 +xref: Reactome:274127 +xref: Reactome:280600 +xref: Reactome:286618 +xref: Reactome:73940 +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0000716 +name: transcription-coupled nucleotide-excision repair, DNA damage recognition +namespace: biological_process +def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] +subset: gosubset_prok +synonym: "pyrimidine-dimer repair, DNA damage recognition" NARROW [] +xref: Reactome:109972 +xref: Reactome:210886 +xref: Reactome:220729 +xref: Reactome:229402 +xref: Reactome:237442 +xref: Reactome:244172 +xref: Reactome:249214 +xref: Reactome:252110 +xref: Reactome:255302 +xref: Reactome:258636 +xref: Reactome:262040 +xref: Reactome:264803 +xref: Reactome:267995 +xref: Reactome:273565 +xref: Reactome:280034 +xref: Reactome:282629 +xref: Reactome:286146 +xref: Reactome:288025 +is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition +relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair + +[Term] +id: GO:0000717 +name: nucleotide-excision repair, DNA duplex unwinding +namespace: biological_process +def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] +subset: gosubset_prok +xref: Reactome:208565 +xref: Reactome:218172 +xref: Reactome:235389 +xref: Reactome:242666 +xref: Reactome:247842 +xref: Reactome:251415 +xref: Reactome:254509 +xref: Reactome:257677 +xref: Reactome:261330 +xref: Reactome:272410 +xref: Reactome:278451 +xref: Reactome:73934 +is_a: GO:0032508 ! DNA duplex unwinding +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0000718 +name: nucleotide-excision repair, DNA damage removal +namespace: biological_process +def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] +subset: gosubset_prok +xref: Reactome:211584 +xref: Reactome:221360 +xref: Reactome:238017 +xref: Reactome:244631 +xref: Reactome:249570 +xref: Reactome:252375 +xref: Reactome:255531 +xref: Reactome:258905 +xref: Reactome:262280 +xref: Reactome:273941 +xref: Reactome:280420 +xref: Reactome:73941 +is_a: GO:0006308 ! DNA catabolic process +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0000719 +name: photoreactive repair +namespace: biological_process +def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] +subset: gosubset_prok +synonym: "pyrimidine-dimer repair by photolyase" NARROW [] +is_a: GO:0006290 ! pyrimidine dimer repair + +[Term] +id: GO:0000720 +name: pyrimidine dimer repair via nucleotide-excision repair +namespace: biological_process +def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] +comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to the biological process term 'nucleotide-excision repair ; GO:0006289' and its children. +subset: gosubset_prok +is_a: GO:0006289 ! nucleotide-excision repair +is_a: GO:0006290 ! pyrimidine dimer repair + +[Term] +id: GO:0000721 +name: (R,R)-butanediol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [EC:1.1.1.4] +subset: gosubset_prok +synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] +synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] +synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] +synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] +synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] +synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] +xref: EC:1.1.1.4 +xref: MetaCyc:(R\,R)-BUTANEDIOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000722 +name: telomere maintenance via recombination +namespace: biological_process +def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] +synonym: "telomerase-independent telomere maintenance" RELATED [] +xref: Reactome:174411 +xref: Reactome:174414 +xref: Reactome:174417 +xref: Reactome:174425 +xref: Reactome:174427 +xref: Reactome:174430 +xref: Reactome:174437 +xref: Reactome:174438 +xref: Reactome:174439 +xref: Reactome:174441 +xref: Reactome:174444 +xref: Reactome:174445 +xref: Reactome:174446 +xref: Reactome:174447 +xref: Reactome:174448 +xref: Reactome:174451 +xref: Reactome:174452 +xref: Reactome:174456 +xref: Reactome:208435 +xref: Reactome:208569 +xref: Reactome:208585 +xref: Reactome:209382 +xref: Reactome:210707 +xref: Reactome:210851 +xref: Reactome:210855 +xref: Reactome:210872 +xref: Reactome:210874 +xref: Reactome:210929 +xref: Reactome:211161 +xref: Reactome:211769 +xref: Reactome:211798 +xref: Reactome:211806 +xref: Reactome:211909 +xref: Reactome:211927 +xref: Reactome:218009 +xref: Reactome:218176 +xref: Reactome:218192 +xref: Reactome:219128 +xref: Reactome:220598 +xref: Reactome:220701 +xref: Reactome:220705 +xref: Reactome:220722 +xref: Reactome:220724 +xref: Reactome:220777 +xref: Reactome:221006 +xref: Reactome:221537 +xref: Reactome:221562 +xref: Reactome:221570 +xref: Reactome:221673 +xref: Reactome:221693 +xref: Reactome:235265 +xref: Reactome:235393 +xref: Reactome:235406 +xref: Reactome:236130 +xref: Reactome:237249 +xref: Reactome:237405 +xref: Reactome:237419 +xref: Reactome:237421 +xref: Reactome:237685 +xref: Reactome:238179 +xref: Reactome:238200 +xref: Reactome:238208 +xref: Reactome:238299 +xref: Reactome:238317 +xref: Reactome:243289 +xref: Reactome:244165 +xref: Reactome:244167 +xref: Reactome:244377 +xref: Reactome:244820 +xref: Reactome:244881 +xref: Reactome:244981 +xref: Reactome:248384 +xref: Reactome:249207 +xref: Reactome:249209 +xref: Reactome:249344 +xref: Reactome:249717 +xref: Reactome:249772 +xref: Reactome:249859 +xref: Reactome:251385 +xref: Reactome:251419 +xref: Reactome:251431 +xref: Reactome:252037 +xref: Reactome:252098 +xref: Reactome:252236 +xref: Reactome:252452 +xref: Reactome:252458 +xref: Reactome:252463 +xref: Reactome:252504 +xref: Reactome:252515 +xref: Reactome:254797 +xref: Reactome:255295 +xref: Reactome:255297 +xref: Reactome:255384 +xref: Reactome:255652 +xref: Reactome:255693 +xref: Reactome:255770 +xref: Reactome:257640 +xref: Reactome:257680 +xref: Reactome:257692 +xref: Reactome:258055 +xref: Reactome:258545 +xref: Reactome:258619 +xref: Reactome:258629 +xref: Reactome:258631 +xref: Reactome:258735 +xref: Reactome:258999 +xref: Reactome:259011 +xref: Reactome:259016 +xref: Reactome:259072 +xref: Reactome:259085 +xref: Reactome:261295 +xref: Reactome:261335 +xref: Reactome:261347 +xref: Reactome:261619 +xref: Reactome:261958 +xref: Reactome:262023 +xref: Reactome:262033 +xref: Reactome:262035 +xref: Reactome:262150 +xref: Reactome:262369 +xref: Reactome:262380 +xref: Reactome:262385 +xref: Reactome:262432 +xref: Reactome:262446 +xref: Reactome:264182 +xref: Reactome:264215 +xref: Reactome:264228 +xref: Reactome:264509 +xref: Reactome:264790 +xref: Reactome:264796 +xref: Reactome:264798 +xref: Reactome:264965 +xref: Reactome:265210 +xref: Reactome:265220 +xref: Reactome:265224 +xref: Reactome:265272 +xref: Reactome:265280 +xref: Reactome:267581 +xref: Reactome:267988 +xref: Reactome:267990 +xref: Reactome:268086 +xref: Reactome:268377 +xref: Reactome:268401 +xref: Reactome:268477 +xref: Reactome:272370 +xref: Reactome:272413 +xref: Reactome:272427 +xref: Reactome:272964 +xref: Reactome:273486 +xref: Reactome:273542 +xref: Reactome:273558 +xref: Reactome:273560 +xref: Reactome:273723 +xref: Reactome:274037 +xref: Reactome:274052 +xref: Reactome:274057 +xref: Reactome:274106 +xref: Reactome:274119 +xref: Reactome:278371 +xref: Reactome:278480 +xref: Reactome:278492 +xref: Reactome:279401 +xref: Reactome:279950 +xref: Reactome:280009 +xref: Reactome:280027 +xref: Reactome:280029 +xref: Reactome:280175 +xref: Reactome:280515 +xref: Reactome:280528 +xref: Reactome:280533 +xref: Reactome:280579 +xref: Reactome:280592 +xref: Reactome:282237 +xref: Reactome:282625 +xref: Reactome:282822 +xref: Reactome:282880 +xref: Reactome:285566 +xref: Reactome:286139 +xref: Reactome:286141 +xref: Reactome:286258 +xref: Reactome:286574 +xref: Reactome:286609 +xref: Reactome:286692 +xref: Reactome:287887 +xref: Reactome:288018 +xref: Reactome:288020 +xref: Reactome:288080 +xref: Reactome:288292 +xref: Reactome:288306 +xref: Reactome:288360 +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0006312 ! mitotic recombination + +[Term] +id: GO:0000723 +name: telomere maintenance +namespace: biological_process +def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] +xref: Reactome:171306 +xref: Reactome:176702 +xref: Reactome:207366 +xref: Reactome:211833 +xref: Reactome:216958 +xref: Reactome:221598 +xref: Reactome:234482 +xref: Reactome:251274 +xref: Reactome:257471 +xref: Reactome:261145 +xref: Reactome:264065 +xref: Reactome:272144 +xref: Reactome:278133 +is_a: GO:0032200 ! telomere organization +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0000724 +name: double-strand break repair via homologous recombination +namespace: biological_process +alt_id: GO:0016924 +def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] +subset: gosubset_prok +synonym: "homologous recombinational repair" EXACT [] +synonym: "HRR" EXACT [] +synonym: "Rhp51-dependent recombinational repair" NARROW [] +xref: Reactome:212096 +xref: Reactome:221855 +xref: Reactome:230426 +xref: Reactome:238484 +xref: Reactome:245027 +xref: Reactome:249917 +xref: Reactome:252628 +xref: Reactome:255811 +xref: Reactome:259208 +xref: Reactome:262566 +xref: Reactome:265387 +xref: Reactome:268519 +xref: Reactome:274245 +xref: Reactome:280711 +xref: Reactome:282918 +xref: Reactome:286734 +xref: Reactome:288398 +xref: Reactome:289894 +xref: Reactome:290425 +xref: Reactome:73888 +is_a: GO:0000725 ! recombinational repair +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0000725 +name: recombinational repair +namespace: biological_process +def: "The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0000726 +name: non-recombinational repair +namespace: biological_process +def: "The repair of damaged DNA that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0000727 +name: double-strand break repair via break-induced replication +namespace: biological_process +def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] +subset: gosubset_prok +is_a: GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0000728 +name: gene conversion at mating-type locus, DNA double-strand break formation +namespace: biological_process +def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0000729 +name: DNA double-strand break processing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] +xref: Reactome:83897 +is_a: GO:0000738 ! DNA catabolic process, exonucleolytic +relationship: part_of GO:0006302 ! double-strand break repair + +[Term] +id: GO:0000730 +name: DNA recombinase assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] +xref: Reactome:211670 +xref: Reactome:221441 +xref: Reactome:230072 +xref: Reactome:238093 +xref: Reactome:244700 +xref: Reactome:249618 +xref: Reactome:252414 +xref: Reactome:255573 +xref: Reactome:258948 +xref: Reactome:262322 +xref: Reactome:265171 +xref: Reactome:268300 +xref: Reactome:273989 +xref: Reactome:280468 +xref: Reactome:282782 +xref: Reactome:286488 +xref: Reactome:288247 +xref: Reactome:289793 +xref: Reactome:290347 +xref: Reactome:76000 +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:0000731 +name: DNA synthesis during DNA repair +namespace: biological_process +def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template." [PMID:10357855] +subset: gosubset_prok +synonym: "DNA repair synthesis" BROAD [] +xref: Reactome:76011 +is_a: GO:0006260 ! DNA replication +relationship: part_of GO:0006281 ! DNA repair + +[Term] +id: GO:0000732 +name: strand displacement +namespace: biological_process +def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] +subset: gosubset_prok +xref: Reactome:83663 +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0000733 +name: DNA strand renaturation +namespace: biological_process +def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0000734 +name: gene conversion at mating-type locus, DNA repair synthesis +namespace: biological_process +def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh] +is_a: GO:0000731 ! DNA synthesis during DNA repair +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0000735 +name: removal of nonhomologous ends +namespace: biological_process +def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0000736 +name: double-strand break repair via single-strand annealing, removal of nonhomologous ends +namespace: biological_process +def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] +subset: gosubset_prok +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0000737 +name: DNA catabolic process, endonucleolytic +namespace: biological_process +def: "The hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh] +subset: gosubset_prok +synonym: "DNA breakdown, endonucleolytic" EXACT [] +synonym: "DNA degradation, endonucleolytic" EXACT [] +synonym: "endonucleolytic degradation of DNA" EXACT [] +is_a: GO:0006308 ! DNA catabolic process + +[Term] +id: GO:0000738 +name: DNA catabolic process, exonucleolytic +namespace: biological_process +def: "The hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh] +subset: gosubset_prok +synonym: "DNA breakdown, exonucleolytic" EXACT [] +synonym: "DNA degradation, exonucleolytic" EXACT [] +synonym: "exonucleolytic degradation of DNA" EXACT [] +is_a: GO:0006308 ! DNA catabolic process + +[Term] +id: GO:0000739 +name: DNA strand annealing activity +namespace: molecular_function +def: "Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] +is_a: GO:0003690 ! double-stranded DNA binding +is_a: GO:0003697 ! single-stranded DNA binding + +[Term] +id: GO:0000740 +name: nuclear membrane fusion +namespace: biological_process +def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] +is_a: GO:0006944 ! membrane fusion + +[Term] +id: GO:0000741 +name: karyogamy +namespace: biological_process +alt_id: GO:0007335 +def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] +synonym: "nuclear fusion" EXACT [] +synonym: "nuclear fusion during karyogamy" EXACT [] +is_a: GO:0048284 ! organelle fusion +relationship: part_of GO:0006997 ! nucleus organization + +[Term] +id: GO:0000742 +name: karyogamy during conjugation with cellular fusion +namespace: biological_process +def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] +is_a: GO:0000741 ! karyogamy +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000743 +name: nuclear migration during conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0006946 +def: "The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt] +synonym: "nuclear congression" BROAD [] +is_a: GO:0030473 ! nuclear migration along microtubule +relationship: part_of GO:0000742 ! karyogamy during conjugation with cellular fusion + +[Term] +id: GO:0000744 +name: karyogamy during conjugation without cellular fusion +namespace: biological_process +def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh] +is_a: GO:0000741 ! karyogamy +relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000745 +name: nuclear migration during conjugation without cellular fusion +namespace: biological_process +def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] +synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0000744 ! karyogamy during conjugation without cellular fusion + +[Term] +id: GO:0000746 +name: conjugation +namespace: biological_process +def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0000747 +name: conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007322 +alt_id: GO:0007333 +alt_id: GO:0030461 +alt_id: GO:0030477 +def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh] +synonym: "cell fusion (mating sensu Saccharomyces)" NARROW [] +synonym: "conjugation (sensu Fungi)" NARROW [] +synonym: "conjugation (sensu Saccharomyces)" NARROW [] +synonym: "mating (sensu Fungi)" NARROW [] +synonym: "mating (sensu Saccharomyces)" NARROW [] +is_a: GO:0000746 ! conjugation +is_a: GO:0019953 ! sexual reproduction + +[Term] +id: GO:0000748 +name: conjugation with mutual genetic exchange +namespace: biological_process +def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] +synonym: "conjugation without cellular fusion" EXACT [] +is_a: GO:0000746 ! conjugation + +[Term] +id: GO:0000749 +name: response to pheromone during conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007328 +alt_id: GO:0030434 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation with cellular fusion." [GOC:clt] +synonym: "pheromone response (sensu Fungi)" NARROW [] +synonym: "pheromone response (sensu Saccharomyces)" NARROW [] +is_a: GO:0019236 ! response to pheromone +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000750 +name: pheromone-dependent signal transduction during conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007330 +alt_id: GO:0030454 +def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:clt] +synonym: "MAPKKK cascade (mating sensu Fungi)" RELATED [] +synonym: "MAPKKK cascade (mating sensu Saccharomyces)" RELATED [] +synonym: "signal transduction of mating signal (sensu Saccharomyces)" NARROW [] +synonym: "transduction of mating signal (sensu Fungi)" NARROW [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway +is_a: GO:0032005 ! signal transduction during conjugation with cellular fusion +relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion + +[Term] +id: GO:0000751 +name: cell cycle arrest in response to pheromone +namespace: biological_process +alt_id: GO:0030571 +def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus." [GOC:clt, GOC:dph, GOC:tb] +synonym: "cell cycle arrest (sensu Saccharomyces)" RELATED [] +is_a: GO:0007050 ! cell cycle arrest +relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion + +[Term] +id: GO:0000752 +name: agglutination during conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007334 +def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] +synonym: "agglutination (sensu Saccharomyces)" NARROW [] +synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] +synonym: "cell-cell adhesion during mating" EXACT [] +is_a: GO:0000771 ! agglutination +relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion + +[Term] +id: GO:0000753 +name: cellular morphogenesis during conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007332 +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] +synonym: "shmoo orientation" NARROW [] +synonym: "shmooing" NARROW [] +is_a: GO:0000767 ! cell morphogenesis during conjugation +relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion + +[Term] +id: GO:0000754 +name: adaptation to pheromone during conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007331 +alt_id: GO:0030453 +def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] +synonym: "adaptation to mating signal (sensu Fungi)" NARROW [] +synonym: "adaptation to mating signal (sensu Saccharomyces)" NARROW [] +synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] +is_a: GO:0019236 ! response to pheromone +is_a: GO:0022401 ! adaptation of signaling pathway +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000755 +name: cytogamy +namespace: biological_process +alt_id: GO:0000218 +alt_id: GO:0030462 +def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing." [GOC:elh] +synonym: "zygote formation (sensu Fungi)" NARROW [] +is_a: GO:0022413 ! reproductive process in single-celled organism +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000756 +name: response to pheromone during conjugation without cellular fusion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt] +is_a: GO:0007154 ! cell communication +is_a: GO:0019236 ! response to pheromone +relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000757 +name: signal transduction during conjugation without cellular fusion +namespace: biological_process +def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway +relationship: part_of GO:0000756 ! response to pheromone during conjugation without cellular fusion + +[Term] +id: GO:0000758 +name: agglutination during conjugation without cellular fusion +namespace: biological_process +def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] +is_a: GO:0000771 ! agglutination +relationship: part_of GO:0000756 ! response to pheromone during conjugation without cellular fusion + +[Term] +id: GO:0000759 +name: cellular morphogenesis during conjugation without cellular fusion +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] +is_a: GO:0000767 ! cell morphogenesis during conjugation +relationship: part_of GO:0000756 ! response to pheromone during conjugation without cellular fusion + +[Term] +id: GO:0000760 +name: adaptation to pheromone during conjugation without cellular fusion +namespace: biological_process +def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] +synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] +is_a: GO:0019236 ! response to pheromone +is_a: GO:0022401 ! adaptation of signaling pathway +relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000761 +name: conjugant formation +namespace: biological_process +def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000762 +name: pheromone-induced unidirectional conjugation +namespace: biological_process +def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] +is_a: GO:0009291 ! unidirectional conjugation + +[Term] +id: GO:0000763 +name: cellular morphogenesis during unidirectional conjugation +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] +is_a: GO:0000767 ! cell morphogenesis during conjugation +relationship: part_of GO:0009291 ! unidirectional conjugation + +[Term] +id: GO:0000764 +name: cellular morphogenesis during pheromone-induced unidirectional conjugation +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] +is_a: GO:0000767 ! cell morphogenesis during conjugation +relationship: part_of GO:0000765 ! response to pheromone during pheromone-induced unidirectional conjugation + +[Term] +id: GO:0000765 +name: response to pheromone during pheromone-induced unidirectional conjugation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of pheromone-induced unidirectional conjugation." [GOC:clt] +is_a: GO:0019236 ! response to pheromone +relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation + +[Term] +id: GO:0000766 +name: adaptation to pheromone during pheromone-induced unidirectional conjugation +namespace: biological_process +def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] +synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] +is_a: GO:0019236 ! response to pheromone +is_a: GO:0022401 ! adaptation of signaling pathway +relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation + +[Term] +id: GO:0000767 +name: cell morphogenesis during conjugation +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] +is_a: GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0000768 +name: syncytium formation by plasma membrane fusion +namespace: biological_process +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] +synonym: "cell fusion" BROAD [] +synonym: "cell-cell fusion" EXACT [] +is_a: GO:0006949 ! syncytium formation +is_a: GO:0045026 ! plasma membrane fusion + +[Term] +id: GO:0000769 +name: syncytium formation by mitosis without cell division +namespace: biological_process +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cell division." [GOC:tb] +is_a: GO:0006949 ! syncytium formation + +[Term] +id: GO:0000770 +name: peptide pheromone export +namespace: biological_process +alt_id: GO:0007325 +def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] +synonym: "a-factor export" NARROW [] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0000771 +name: agglutination +namespace: biological_process +def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] +is_a: GO:0007157 ! heterophilic cell adhesion +relationship: part_of GO:0000746 ! conjugation + +[Term] +id: GO:0000772 +name: mating pheromone activity +namespace: molecular_function +def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] +is_a: GO:0005186 ! pheromone activity + +[Term] +id: GO:0000773 +name: phosphatidyl-N-methylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] +subset: gosubset_prok +synonym: "methyltransferase II" RELATED [EC:2.1.1.71] +synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] +synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] +synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] +synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] +synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] +synonym: "PLMT" EXACT [] +synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] +xref: EC:2.1.1.71 +xref: MetaCyc:2.1.1.71-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0000774 +name: adenyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] +subset: gosubset_prok +is_a: GO:0030554 ! adenyl nucleotide binding + +[Term] +id: GO:0000775 +name: chromosome, centromeric region +namespace: cellular_component +def: "The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] +comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "centromere" RELATED [] +synonym: "chromosome, centric region" EXACT [] +synonym: "chromosome, pericentric region" RELATED [] +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0000776 +name: kinetochore +namespace: cellular_component +alt_id: GO:0005699 +def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] +subset: goslim_pir +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0000777 +name: condensed chromosome kinetochore +namespace: cellular_component +def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] +is_a: GO:0000776 ! kinetochore +relationship: part_of GO:0000779 ! condensed chromosome, centromeric region + +[Term] +id: GO:0000778 +name: condensed nuclear chromosome kinetochore +namespace: cellular_component +def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh] +is_a: GO:0000777 ! condensed chromosome kinetochore +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region + +[Term] +id: GO:0000779 +name: condensed chromosome, centromeric region +namespace: cellular_component +def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] +comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "condensed chromosome, centric region" EXACT [] +synonym: "condensed chromosome, centromere" RELATED [] +synonym: "condensed chromosome, pericentric region" RELATED [] +is_a: GO:0000775 ! chromosome, centromeric region +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0000780 +name: condensed nuclear chromosome, centromeric region +namespace: cellular_component +def: "The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] +comment: Note that this term can be used in place of the obsoleted cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "condensed nuclear chromosome, centric region" EXACT [] +synonym: "condensed nuclear chromosome, centromere" RELATED [] +synonym: "condensed nuclear chromosome, pericentric region" RELATED [] +is_a: GO:0000779 ! condensed chromosome, centromeric region +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0000781 +name: chromosome, telomeric region +namespace: cellular_component +def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] +comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "telomere" RELATED [] +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0000782 +name: telomere cap complex +namespace: cellular_component +def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] +comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000781 ! chromosome, telomeric region + +[Term] +id: GO:0000783 +name: nuclear telomere cap complex +namespace: cellular_component +def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] +comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. +is_a: GO:0000782 ! telomere cap complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region + +[Term] +id: GO:0000784 +name: nuclear chromosome, telomeric region +namespace: cellular_component +def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh] +comment: Note that this term can be used in place of the obsoleted cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "nuclear chromosome, telomere" EXACT [] +is_a: GO:0000781 ! chromosome, telomeric region +is_a: GO:0044454 ! nuclear chromosome part + +[Term] +id: GO:0000785 +name: chromatin +namespace: cellular_component +alt_id: GO:0005717 +def: "The ordered and organized complex of DNA and protein that forms the chromosome." [GOC:elh] +synonym: "chromosome scaffold" RELATED [] +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0000786 +name: nucleosome +namespace: cellular_component +alt_id: GO:0005718 +def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] +subset: goslim_pir +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0000787 +name: cytoplasmic nucleosome +namespace: cellular_component +def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] +is_a: GO:0000786 ! nucleosome +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0000789 ! cytoplasmic chromatin + +[Term] +id: GO:0000788 +name: nuclear nucleosome +namespace: cellular_component +def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] +is_a: GO:0000786 ! nucleosome +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000790 ! nuclear chromatin + +[Term] +id: GO:0000789 +name: cytoplasmic chromatin +namespace: cellular_component +def: "The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm." [GOC:elh] +is_a: GO:0000785 ! chromatin +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0000229 ! cytoplasmic chromosome + +[Term] +id: GO:0000790 +name: nuclear chromatin +namespace: cellular_component +def: "The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus." [GOC:elh] +is_a: GO:0000785 ! chromatin +is_a: GO:0044454 ! nuclear chromosome part + +[Term] +id: GO:0000791 +name: euchromatin +namespace: cellular_component +def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] +is_a: GO:0000785 ! chromatin + +[Term] +id: GO:0000792 +name: heterochromatin +namespace: cellular_component +def: "A compact and highly condensed form of chromatin." [GOC:elh] +is_a: GO:0000785 ! chromatin + +[Term] +id: GO:0000793 +name: condensed chromosome +namespace: cellular_component +def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] +comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. +synonym: "cytoplasmic mitotic chromosome" RELATED [] +synonym: "metaphase chromosome" RELATED [] +synonym: "mitotic chromosome" RELATED [] +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0000794 +name: condensed nuclear chromosome +namespace: cellular_component +def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh] +comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. +synonym: "meiotic chromosome" RELATED [] +synonym: "nuclear mitotic chromosome" RELATED [] +is_a: GO:0000228 ! nuclear chromosome +is_a: GO:0000793 ! condensed chromosome + +[Term] +id: GO:0000795 +name: synaptonemal complex +namespace: cellular_component +alt_id: GO:0005716 +def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0000796 +name: condensin complex +namespace: cellular_component +alt_id: GO:0005676 +alt_id: GO:0008620 +def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] +subset: goslim_pir +synonym: "13S condensin complex" NARROW [] +synonym: "SMC complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0000797 +name: condensin core heterodimer +namespace: cellular_component +alt_id: GO:0008621 +def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] +synonym: "8S condensin complex" NARROW [] +synonym: "Smc2-Smc4 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000796 ! condensin complex + +[Term] +id: GO:0000798 +name: nuclear cohesin complex +namespace: cellular_component +def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] +comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. +is_a: GO:0008278 ! cohesin complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0000799 +name: nuclear condensin complex +namespace: cellular_component +def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] +is_a: GO:0000796 ! condensin complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0000800 +name: lateral element +namespace: cellular_component +def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] +synonym: "axial element" RELATED [] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000795 ! synaptonemal complex + +[Term] +id: GO:0000801 +name: central element +namespace: cellular_component +def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000795 ! synaptonemal complex + +[Term] +id: GO:0000802 +name: transverse filament +namespace: cellular_component +def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000795 ! synaptonemal complex + +[Term] +id: GO:0000803 +name: sex chromosome +namespace: cellular_component +def: "A chromosome involved in sex determination." [GOC:elh] +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0000804 +name: W chromosome +namespace: cellular_component +def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000805 +name: X chromosome +namespace: cellular_component +def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000806 +name: Y chromosome +namespace: cellular_component +def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000807 +name: Z chromosome +namespace: cellular_component +def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000808 +name: origin recognition complex +namespace: cellular_component +def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] +subset: goslim_pir +subset: gosubset_prok +synonym: "ORC" EXACT [] +synonym: "origin of replication recognition complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0000809 +name: cytoplasmic origin of replication recognition complex +namespace: cellular_component +def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] +subset: gosubset_prok +synonym: "cytoplasmic ORC" EXACT [] +synonym: "prokaryotic ORC" RELATED [] +is_a: GO:0000808 ! origin recognition complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0000229 ! cytoplasmic chromosome + +[Term] +id: GO:0000810 +name: diacylglycerol pyrophosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate." [EC:3.6.1.-, PMID:8567632, PMID:9452443] +synonym: "DGPP phosphatase activity" EXACT [] +synonym: "DGPP phosphohydrolase activity" EXACT [] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0000811 +name: GINS complex +namespace: cellular_component +def: "A multisubunit complex that associates with replication origins and is required for the initiation of DNA replication." [GOC:rn, PMID:12730134] +synonym: "Go, Ichi, Ni and San complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part + +[Term] +id: GO:0000812 +name: SWR1 complex +namespace: cellular_component +def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608] +synonym: "SWR-C" EXACT [] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0000813 +name: ESCRT I complex +namespace: cellular_component +def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] +synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0000814 +name: ESCRT II complex +namespace: cellular_component +def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] +synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0000815 +name: ESCRT III complex +namespace: cellular_component +def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] +synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0000816 +name: nicotinamide riboside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinamide riboside = ADP + nicotinamide nucleotide (NMN)." [PMID:15137942] +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0000817 +name: COMA complex +namespace: cellular_component +def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm1p, Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] +synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore + +[Term] +id: GO:0000818 +name: nuclear MIS12/MIND type complex +namespace: cellular_component +def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] +synonym: "MIND complex" EXACT [] +synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] +is_a: GO:0000444 ! MIS12/MIND type complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore + +[Term] +id: GO:0000819 +name: sister chromatid segregation +namespace: biological_process +def: "The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0000820 +name: regulation of glutamine family amino acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] +synonym: "regulation of glutamine family amino acid metabolism" EXACT [] +is_a: GO:0006521 ! regulation of amino acid metabolic process +relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0000821 +name: regulation of arginine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators] +synonym: "regulation of arginine metabolism" EXACT [] +is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process +relationship: regulates GO:0006525 ! arginine metabolic process + +[Term] +id: GO:0000822 +name: inositol hexakisphosphate binding +namespace: molecular_function +def: "Interacting selectively with inositol hexakisphosphate." [GOC:go_curators] +synonym: "InsP6 binding" EXACT [] +synonym: "IP6 binding" EXACT [] +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0000823 +name: inositol trisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate." [GOC:elh] +synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] +synonym: "EC:2.7.1.151" BROAD [] +synonym: "inositol polyphosphate multikinase activity" BROAD [] +synonym: "IpmK" BROAD [] +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0000824 +name: inositol tetrakisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] +synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] +synonym: "EC:2.7.1.151" BROAD [] +synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] +synonym: "inositol polyphosphate multikinase activity" BROAD [] +synonym: "IpmK" BROAD [] +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0000825 +name: inositol tetrakisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] +synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] +synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0000826 +name: inositol pyrophosphate synthase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of inositol phosphates which possess pyrophosphate bonds." [GOC:elh, PMID:16429326] +synonym: "inositol diphosphate synthase activity" EXACT [] +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0000827 +name: inositol 1,3,4,5,6-pentakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [GOC:elh, PMID:11311242] +synonym: "EC:2.7.4.21" BROAD [] +is_a: GO:0000826 ! inositol pyrophosphate synthase activity + +[Term] +id: GO:0000828 +name: inositol hexakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate (IP6) = ADP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown)." [GOC:elh, PMID:16429326] +is_a: GO:0000826 ! inositol pyrophosphate synthase activity + +[Term] +id: GO:0000829 +name: inositol heptakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown) = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4; isomer unknown)." [GOC:elh, PMID:16429326] +is_a: GO:0000826 ! inositol pyrophosphate synthase activity + +[Term] +id: GO:0000830 +name: inositol hexakisphosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] +is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity + +[Term] +id: GO:0000831 +name: inositol hexakisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] +is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity + +[Term] +id: GO:0000832 +name: inositol hexakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [GOC:elh, PMID:16429326] +synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] +synonym: "EC:2.7.4.21" BROAD [] +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0000833 +name: inositol heptakisphosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] +synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] +synonym: "IP7 4-kinase activity" EXACT [] +is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity + +[Term] +id: GO:0000834 +name: inositol heptakisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] +is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity + +[Term] +id: GO:0000835 +name: ER ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex found in the ER." [GOC:elh] +is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0000836 +name: Hrd1p ubiquitin ligase complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] +is_a: GO:0000835 ! ER ubiquitin ligase complex + +[Term] +id: GO:0000837 +name: Doa10p ubiquitin ligase complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] +synonym: "Ssm4p ubiquitin ligase complex" EXACT [] +is_a: GO:0000835 ! ER ubiquitin ligase complex + +[Term] +id: GO:0000838 +name: Hrd1p ubiquitin ligase ERAD-M complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] +is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex + +[Term] +id: GO:0000839 +name: Hrd1p ubiquitin ligase ERAD-L complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] +is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex + +[Term] +id: GO:0000900 +name: translation repressor activity, nucleic acid binding +namespace: molecular_function +def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [GOC:clt] +is_a: GO:0008135 ! translation factor activity, nucleic acid binding +is_a: GO:0030371 ! translation repressor activity + +[Term] +id: GO:0000901 +name: translation repressor activity, non-nucleic acid binding +namespace: molecular_function +def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] +is_a: GO:0030371 ! translation repressor activity +is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding + +[Term] +id: GO:0000902 +name: cell morphogenesis +namespace: biological_process +alt_id: GO:0007148 +alt_id: GO:0045790 +alt_id: GO:0045791 +def: "The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +synonym: "cellular morphogenesis" EXACT [] +is_a: GO:0032989 ! cellular structure morphogenesis + +[Term] +id: GO:0000903 +name: cellular morphogenesis during vegetative growth +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during the development of a cell as it progresses through a mitotic cell cycle when it is not undergoing terminal differentiation." [GOC:clt, GOC:go_curators] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0016049 ! cell growth + +[Term] +id: GO:0000904 +name: cell morphogenesis involved in differentiation +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0000905 +name: sporocarp development involved in asexual reproduction +namespace: biological_process +def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] +synonym: "conidium development" NARROW [] +synonym: "fruiting body formation during asexual reproduction (sensu Fungi)" EXACT [] +synonym: "haploid fruiting" RELATED [] +synonym: "homokaryotic fruiting" RELATED [] +synonym: "imperfect stage fruiting body development" NARROW [] +synonym: "monokaryotic fruiting" RELATED [] +is_a: GO:0030584 ! sporocarp development +relationship: part_of GO:0019954 ! asexual reproduction + +[Term] +id: GO:0000906 +name: 6,7-dimethyl-8-ribityllumazine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556] +synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] +xref: EC:5.4.-.- +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0000907 +name: sulfonate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] +subset: gosubset_prok +synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] +synonym: "sulphonate dioxygenase activity" EXACT [] +xref: EC:1.14.11.- +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0000908 +name: taurine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: taurine + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.17, MetaCyc:RXN0-299] +subset: gosubset_prok +synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] +synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] +synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] +xref: EC:1.14.11.17 +xref: MetaCyc:RXN0-299 +is_a: GO:0000907 ! sulfonate dioxygenase activity + +[Term] +id: GO:0000909 +name: sporocarp development involved in sexual reproduction +namespace: biological_process +def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] +synonym: "ascus development" NARROW [] +synonym: "fruiting body development during sexual reproduction (sensu Fungi)" EXACT [] +synonym: "fruiting body formation during sexual reproduction (sensu Fungi)" EXACT [] +synonym: "perfect stage fruiting body development" NARROW [] +is_a: GO:0030584 ! sporocarp development +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0000910 +name: cytokinesis +namespace: biological_process +alt_id: GO:0007104 +alt_id: GO:0016288 +def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai] +subset: goslim_candida +subset: goslim_yeast +subset: gosubset_prok +xref: Reactome:211912 +xref: Reactome:221676 +xref: Reactome:230265 +xref: Reactome:238302 +xref: Reactome:244868 +xref: Reactome:249758 +xref: Reactome:252506 +xref: Reactome:259076 +xref: Reactome:262434 +xref: Reactome:265269 +xref: Reactome:268395 +xref: Reactome:282835 +xref: Reactome:286599 +xref: Reactome:68884 +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0000911 +name: cytokinesis by cell plate formation +namespace: biological_process +def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells." [GOC:clt] +synonym: "cytokinesis (sensu Viridiplantae)" NARROW [] +is_a: GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0000912 +name: formation of actomyosin apparatus involved in cytokinesis +namespace: biological_process +def: "The formation of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt] +synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031032 ! actomyosin structure organization +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0000913 +name: preprophase band formation +namespace: biological_process +def: "The process of marking the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt] +is_a: GO:0007105 ! cytokinesis, site selection +relationship: part_of GO:0000911 ! cytokinesis by cell plate formation + +[Term] +id: GO:0000914 +name: phragmoplast formation +namespace: biological_process +def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] +is_a: GO:0000912 ! formation of actomyosin apparatus involved in cytokinesis +relationship: part_of GO:0000911 ! cytokinesis by cell plate formation + +[Term] +id: GO:0000915 +name: cytokinesis, contractile ring formation +namespace: biological_process +alt_id: GO:0045573 +def: "The process of formation of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt] +synonym: "constriction ring assembly" NARROW [] +synonym: "cytokinesis, actomyosin ring biosynthesis" EXACT [] +synonym: "cytokinesis, actomyosin ring formation" EXACT [] +synonym: "cytokinesis, contractile ring assembly" NARROW [] +is_a: GO:0000912 ! formation of actomyosin apparatus involved in cytokinesis + +[Term] +id: GO:0000916 +name: contractile ring contraction involved in cytokinesis +namespace: biological_process +def: "The process of an actomyosin ring, which functions in cytokinesis, getting smaller in diameter." [GOC:clt, GOC:dph, GOC:tb] +synonym: "cytokinesis, actomyosin ring contraction" EXACT [] +synonym: "cytokinesis, contractile ring contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0000917 +name: barrier septum formation +namespace: biological_process +def: "The process of making a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:clt] +synonym: "formation of barrier septum" EXACT [] +synonym: "septation" BROAD [] +synonym: "septin assembly and septum biosynthesis" RELATED [] +synonym: "septin assembly and septum formation" RELATED [] +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0000918 +name: selection of site for barrier septum formation +namespace: biological_process +def: "The process of marking the site where a barrier septum will form." [GOC:clt] +synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] +synonym: "selection of site for barrier cell septum formation" EXACT [] +synonym: "septin assembly and septum biosynthesis" BROAD [] +synonym: "septin assembly and septum formation" BROAD [] +synonym: "septum positioning" EXACT [] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000917 ! barrier septum formation + +[Term] +id: GO:0000919 +name: cell plate formation +namespace: biological_process +def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000911 ! cytokinesis by cell plate formation + +[Term] +id: GO:0000920 +name: cell separation during cytokinesis +namespace: biological_process +def: "The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:clt] +synonym: "rotokinesis" NARROW [] +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0000921 +name: septin ring assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] +subset: gosubset_prok +synonym: "septin assembly and septum biosynthesis" BROAD [] +synonym: "septin assembly and septum formation" BROAD [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0031106 ! septin ring organization + +[Term] +id: GO:0000922 +name: spindle pole +namespace: cellular_component +alt_id: GO:0030615 +def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0000923 +name: equatorial microtubule organizing center +namespace: cellular_component +def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] +synonym: "EMTOC" EXACT [] +synonym: "equatorial microtubule organising centre" EXACT [] +is_a: GO:0005815 ! microtubule organizing center +is_a: GO:0032155 ! cell division site part + +[Term] +id: GO:0000924 +name: gamma-tubulin ring complex, centrosomal +namespace: cellular_component +alt_id: GO:0000925 +alt_id: GO:0000926 +def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] +synonym: "gamma-tubulin large complex (sensu Metazoa)" EXACT [] +synonym: "gamma-tubulin large complex, centrosomal" EXACT [] +synonym: "gamma-tubulin ring complex, centrosomal (sensu Metazoa)" EXACT [] +is_a: GO:0008274 ! gamma-tubulin ring complex +relationship: part_of GO:0000242 ! pericentriolar material + +[Term] +id: GO:0000927 +name: gamma-tubulin small complex, centrosomal +namespace: cellular_component +def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [GOC:mtg_sensu, PMID:12134075] +synonym: "gamma-tubulin small complex (sensu Metazoa)" EXACT [] +is_a: GO:0008275 ! gamma-tubulin small complex + +[Term] +id: GO:0000928 +name: gamma-tubulin small complex, spindle pole body +namespace: cellular_component +def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms." [GOC:mtg_sensu, PMID:12134075] +synonym: "gamma-tubulin complex (sensu Saccharomyces)" BROAD [] +synonym: "Tub4 complex" EXACT [] +is_a: GO:0008275 ! gamma-tubulin small complex +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0000930 +name: gamma-tubulin complex +namespace: cellular_component +def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044450 ! microtubule organizing center part + +[Term] +id: GO:0000931 +name: gamma-tubulin large complex +namespace: cellular_component +alt_id: GO:0000929 +def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes." [GOC:mtg_sensu, PMID:12134075] +synonym: "gamma-tubulin large complex (sensu Schizosaccharomyces)" EXACT [] +is_a: GO:0000930 ! gamma-tubulin complex + +[Term] +id: GO:0000932 +name: cytoplasmic mRNA processing body +namespace: cellular_component +def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] +synonym: "cytoplasmic foci" RELATED [] +synonym: "P body" EXACT [] +synonym: "P-body" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0000933 +name: adventitious septum +namespace: cellular_component +def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0000934 +name: porous cell septum +namespace: cellular_component +def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] +synonym: "porous septum" BROAD [] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0000935 +name: barrier septum +namespace: cellular_component +def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt] +synonym: "complete septum" EXACT [] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0000936 +name: primary cell septum +namespace: cellular_component +def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] +synonym: "primary septum" BROAD [] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0000937 +name: dolipore septum +namespace: cellular_component +def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] +is_a: GO:0000934 ! porous cell septum + +[Term] +id: GO:0000938 +name: GARP complex +namespace: cellular_component +def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] +synonym: "Golgi associated retrograde protein complex" EXACT [] +synonym: "VFT tethering complex" EXACT [] +synonym: "Vps fifty three tethering complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044431 ! Golgi apparatus part +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0000939 +name: inner kinetochore of condensed chromosome +namespace: cellular_component +def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] +synonym: "inner centromere core complex" RELATED [] +synonym: "inner kinetochore plate" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000777 ! condensed chromosome kinetochore + +[Term] +id: GO:0000940 +name: outer kinetochore of condensed chromosome +namespace: cellular_component +def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] +synonym: "outer kinetochore plate" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000777 ! condensed chromosome kinetochore + +[Term] +id: GO:0000941 +name: inner kinetochore of condensed nuclear chromosome +namespace: cellular_component +def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] +is_a: GO:0000939 ! inner kinetochore of condensed chromosome +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore + +[Term] +id: GO:0000942 +name: outer kinetochore of condensed nuclear chromosome +namespace: cellular_component +def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] +is_a: GO:0000940 ! outer kinetochore of condensed chromosome +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore + +[Term] +id: GO:0000943 +name: retrotransposon nucleocapsid +namespace: cellular_component +def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] +synonym: "Virus-like particle" EXACT [] +synonym: "VLP" EXACT [] +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0000944 +name: base pairing with rRNA +namespace: molecular_function +def: "Interacting selectively with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0000498 ! base pairing with RNA +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0000945 +name: base pairing with snRNA +namespace: molecular_function +def: "Interacting selectively with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0000498 ! base pairing with RNA +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0000946 +name: base pairing with tRNA +namespace: molecular_function +def: "Interacting selectively with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +is_a: GO:0000049 ! tRNA binding +is_a: GO:0000498 ! base pairing with RNA + +[Term] +id: GO:0000947 +name: amino acid catabolic process to alcohol via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0000948 +name: amino acid catabolic process to carboxylic acid via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0000949 +name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway +is_a: GO:0009074 ! aromatic amino acid family catabolic process + +[Term] +id: GO:0000950 +name: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway +is_a: GO:0009083 ! branched chain family amino acid catabolic process + +[Term] +id: GO:0000951 +name: methionine catabolic process to 3-methylthiopropanol +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway +is_a: GO:0009087 ! methionine catabolic process + +[Term] +id: GO:0000952 +name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway +is_a: GO:0009074 ! aromatic amino acid family catabolic process + +[Term] +id: GO:0000953 +name: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway +is_a: GO:0009083 ! branched chain family amino acid catabolic process + +[Term] +id: GO:0000954 +name: methionine catabolic process to 3-methylthiopropanoate +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway +is_a: GO:0009087 ! methionine catabolic process + +[Term] +id: GO:0000955 +name: amino acid catabolic process via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0009063 ! amino acid catabolic process + +[Term] +id: GO:0000956 +name: nuclear-transcribed mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] +synonym: "nuclear mRNA breakdown" EXACT [] +synonym: "nuclear mRNA catabolism" EXACT [] +synonym: "nuclear mRNA degradation" EXACT [] +is_a: GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:0000957 +name: mitochondrial RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0000958 +name: mitochondrial mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0000957 ! mitochondrial RNA catabolic process +is_a: GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:0000959 +name: mitochondrial RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0000960 +name: regulation of mitochondrial RNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process + +[Term] +id: GO:0000961 +name: negative regulation of mitochondrial RNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] +is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process + +[Term] +id: GO:0000962 +name: positive regulation of mitochondrial RNA catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] +is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process + +[Term] +id: GO:0000963 +name: mitochondrial RNA processing +namespace: biological_process +def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0000964 +name: mitochondrial RNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] +synonym: "mitochondrial RNA 5' end processing" RELATED [] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0000966 ! RNA 5'-end processing + +[Term] +id: GO:0000965 +name: mitochondrial RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] +synonym: "mitochondrial RNA 3' end processing" RELATED [] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0000966 +name: RNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] +synonym: "RNA 5' end processing" EXACT [] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0000967 +name: rRNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] +synonym: "rRNA 5'-end processing" EXACT [] +is_a: GO:0034471 ! ncRNA 5'-end processing + +[Term] +id: GO:0001100 +name: negative regulation of exit from mitosis +namespace: biological_process +def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] +synonym: "down regulation of exit from mitosis" EXACT [] +synonym: "down-regulation of exit from mitosis" EXACT [] +synonym: "downregulation of exit from mitosis" EXACT [] +synonym: "inhibition of exit from mitosis" NARROW [] +is_a: GO:0007096 ! regulation of exit from mitosis +is_a: GO:0045839 ! negative regulation of mitosis +relationship: negatively_regulates GO:0010458 ! exit from mitosis + +[Term] +id: GO:0001101 +name: response to acid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:rn] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0001300 +name: chronological cell aging +namespace: biological_process +def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] +synonym: "chronological cell ageing" EXACT [] +is_a: GO:0007569 ! cell aging + +[Term] +id: GO:0001301 +name: progressive alteration of chromatin during cell aging +namespace: biological_process +def: "The process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938] +synonym: "age-dependent accumulation of genetic damage" RELATED [] +synonym: "progressive alteration of chromatin during cell ageing" EXACT [] +is_a: GO:0016568 ! chromatin modification +relationship: part_of GO:0007569 ! cell aging + +[Term] +id: GO:0001302 +name: replicative cell aging +namespace: biological_process +def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] +synonym: "replicative cell ageing" EXACT [] +is_a: GO:0007569 ! cell aging + +[Term] +id: GO:0001303 +name: nucleolar fragmentation during replicative aging +namespace: biological_process +def: "Process of enlargement and fragmentation of the nucleolus into multiple rounded structures that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] +synonym: "nucleolar fragmentation during replicative ageing" EXACT [] +is_a: GO:0007576 ! nucleolar fragmentation +relationship: part_of GO:0001302 ! replicative cell aging + +[Term] +id: GO:0001304 +name: progressive alteration of chromatin during replicative cell aging +namespace: biological_process +def: "The process that occurs in dividing cells as they age that results in changes to chromatin structure." [GOC:jh] +synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] +is_a: GO:0001301 ! progressive alteration of chromatin during cell aging +relationship: part_of GO:0001302 ! replicative cell aging + +[Term] +id: GO:0001305 +name: progressive alteration of chromatin during chronological cell aging +namespace: biological_process +def: "The process that occurs in non-dividing cells as they age that results in changes to chromatin structure." [GOC:jh] +synonym: "progressive alteration of chromatin during chronological cell ageing" EXACT [] +is_a: GO:0001301 ! progressive alteration of chromatin during cell aging +relationship: part_of GO:0001300 ! chronological cell aging + +[Term] +id: GO:0001306 +name: age-dependent response to oxidative stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:0007571 ! age-dependent general metabolic decline + +[Term] +id: GO:0001307 +name: extrachromosomal circular DNA accumulation during replicative cell aging +namespace: biological_process +def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] +synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" EXACT [] +is_a: GO:0001304 ! progressive alteration of chromatin during replicative cell aging +is_a: GO:0007580 ! extrachromosomal circular DNA accumulation during cell aging + +[Term] +id: GO:0001308 +name: loss of chromatin silencing during replicative cell aging +namespace: biological_process +def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] +synonym: "loss of chromatin silencing during replicative cell ageing" EXACT [] +is_a: GO:0001304 ! progressive alteration of chromatin during replicative cell aging +is_a: GO:0006345 ! loss of chromatin silencing + +[Term] +id: GO:0001309 +name: age-dependent telomere shortening +namespace: biological_process +def: "Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] +is_a: GO:0001304 ! progressive alteration of chromatin during replicative cell aging +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0032200 ! telomere organization + +[Term] +id: GO:0001310 +name: extrachromosomal rDNA circle accumulation during replicative cell aging +namespace: biological_process +def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] +synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" EXACT [] +synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" EXACT [] +is_a: GO:0001307 ! extrachromosomal circular DNA accumulation during replicative cell aging + +[Term] +id: GO:0001311 +name: formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging +namespace: biological_process +def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] +synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" EXACT [] +synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" EXACT [] +is_a: GO:0001313 ! formation of extrachromosomal circular DNA during replicative cell aging +relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation during replicative cell aging + +[Term] +id: GO:0001312 +name: replication of extrachromosomal rDNA circles during replicative cell aging +namespace: biological_process +def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] +synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" EXACT [] +synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" EXACT [] +is_a: GO:0001314 ! replication of extrachromosomal circular DNA during replicative cell aging +relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation during replicative cell aging + +[Term] +id: GO:0001313 +name: formation of extrachromosomal circular DNA during replicative cell aging +namespace: biological_process +def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] +synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" EXACT [] +is_a: GO:0001325 ! formation of extrachromosomal circular DNA +relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation during replicative cell aging + +[Term] +id: GO:0001314 +name: replication of extrachromosomal circular DNA during replicative cell aging +namespace: biological_process +def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] +synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] +is_a: GO:0001326 ! replication of extrachromosomal circular DNA +relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation during replicative cell aging + +[Term] +id: GO:0001315 +name: age-dependent response to reactive oxygen species +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] +subset: gosubset_prok +synonym: "age-dependent response to active oxygen species" EXACT [] +synonym: "age-dependent response to AOS" EXACT [] +synonym: "age-dependent response to reactive oxidative species" EXACT [] +synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] +synonym: "age-dependent response to ROI" EXACT [] +synonym: "age-dependent response to ROS" EXACT [] +is_a: GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:0001316 +name: age-dependent response to reactive oxygen species during replicative cell aging +namespace: biological_process +def: "A change in state or activity of a cell or an organism occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] +synonym: "age-dependent response to active oxygen species during replicative cell aging" EXACT [] +synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] +synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] +synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" EXACT [] +synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] +synonym: "age-dependent response to ROI during replicative cell aging" EXACT [] +synonym: "age-dependent response to ROS during replicative cell aging" EXACT [] +is_a: GO:0001315 ! age-dependent response to reactive oxygen species +is_a: GO:0001322 ! age-dependent response to oxidative stress during replicative cell aging + +[Term] +id: GO:0001317 +name: accumulation of oxidatively modified proteins during replicative cell aging +namespace: biological_process +def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] +synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" EXACT [] +is_a: GO:0001316 ! age-dependent response to reactive oxygen species during replicative cell aging + +[Term] +id: GO:0001318 +name: formation of oxidatively modified proteins during replicative cell aging +namespace: biological_process +def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] +synonym: "formation of oxidatively modified proteins during replicative cell ageing" EXACT [] +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins during replicative cell aging + +[Term] +id: GO:0001319 +name: inheritance of oxidatively modified proteins during replicative cell aging +namespace: biological_process +def: "Process by which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] +synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" EXACT [] +is_a: GO:0008105 ! asymmetric protein localization +relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins during replicative cell aging + +[Term] +id: GO:0001320 +name: age-dependent response to reactive oxygen species during chronological cell aging +namespace: biological_process +def: "A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] +synonym: "age-dependent response to active oxygen species during chronological cell aging" EXACT [] +synonym: "age-dependent response to AOS during chronological cell aging" EXACT [] +synonym: "age-dependent response to reactive oxidative species during chronological cell aging" EXACT [] +synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" EXACT [] +synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" EXACT [] +synonym: "age-dependent response to ROI during chronological cell aging" EXACT [] +synonym: "age-dependent response to ROS during chronological cell aging" EXACT [] +is_a: GO:0001315 ! age-dependent response to reactive oxygen species +is_a: GO:0001324 ! age-dependent response to oxidative stress during chronological cell aging + +[Term] +id: GO:0001321 +name: age-dependent general metabolic decline during replicative cell aging +namespace: biological_process +def: "The process, arising in dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function." [GOC:jh] +synonym: "age-dependent general metabolic decline during replicative cell ageing" EXACT [] +is_a: GO:0007571 ! age-dependent general metabolic decline +relationship: part_of GO:0001302 ! replicative cell aging + +[Term] +id: GO:0001322 +name: age-dependent response to oxidative stress during replicative cell aging +namespace: biological_process +def: "A change in state or activity of a cell or an organism occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] +synonym: "age-dependent response to oxidative stress during replicative cell ageing" EXACT [] +is_a: GO:0001306 ! age-dependent response to oxidative stress +is_a: GO:0001321 ! age-dependent general metabolic decline during replicative cell aging + +[Term] +id: GO:0001323 +name: age-dependent general metabolic decline during chronological cell aging +namespace: biological_process +def: "The process, arising in non-dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function." [GOC:jh] +synonym: "age-dependent general metabolic decline during chronological cell ageing" EXACT [] +is_a: GO:0007571 ! age-dependent general metabolic decline +relationship: part_of GO:0001300 ! chronological cell aging + +[Term] +id: GO:0001324 +name: age-dependent response to oxidative stress during chronological cell aging +namespace: biological_process +def: "A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] +synonym: "age-dependent response to oxidative stress during chronological cell ageing" EXACT [] +is_a: GO:0001306 ! age-dependent response to oxidative stress +is_a: GO:0001323 ! age-dependent general metabolic decline during chronological cell aging + +[Term] +id: GO:0001325 +name: formation of extrachromosomal circular DNA +namespace: biological_process +def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] +subset: gosubset_prok +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic + +[Term] +id: GO:0001326 +name: replication of extrachromosomal circular DNA +namespace: biological_process +def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] +subset: gosubset_prok +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0001400 +name: mating projection base +namespace: cellular_component +def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] +synonym: "base of shmoo tip" NARROW [] +synonym: "conjugation tube base" NARROW [] +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0001401 +name: mitochondrial sorting and assembly machinery complex +namespace: cellular_component +def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] +comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. +synonym: "SAM complex" EXACT [] +synonym: "TOB complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0001402 +name: signal transduction during filamentous growth +namespace: biological_process +def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] +synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0030447 ! filamentous growth + +[Term] +id: GO:0001403 +name: invasive growth in response to glucose limitation +namespace: biological_process +def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium." [GOC:mcc, PMID:9728395] +comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'invasive growth', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. +synonym: "colony morphology" RELATED [] +synonym: "invasive growth (sensu Saccharomyces)" EXACT [] +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0001404 +name: invasive growth +namespace: biological_process +def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "tissue invasion" EXACT [] +is_obsolete: true +consider: GO:0044409 +consider: GO:0044412 + +[Term] +id: GO:0001405 +name: presequence translocase-associated import motor +namespace: cellular_component +def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855] +synonym: "mitochondrial import motor" EXACT [] +synonym: "PAM complex" EXACT [] +synonym: "pre-sequence translocase-associated import motor" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex + +[Term] +id: GO:0001406 +name: glycerophosphodiester transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity + +[Term] +id: GO:0001407 +name: glycerophosphodiester transport +namespace: biological_process +def: "The directed movement of glycerophosphodiesters into, out of, within or between cells. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] +is_a: GO:0015748 ! organophosphate ester transport + +[Term] +id: GO:0001408 +name: guanine nucleotide transport +namespace: biological_process +def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of, within or between cells." [GOC:mcc] +is_a: GO:0015865 ! purine nucleotide transport + +[Term] +id: GO:0001409 +name: guanine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc] +is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity + +[Term] +id: GO:0001410 +name: chlamydospore formation +namespace: biological_process +alt_id: GO:0055027 +def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] +synonym: "chlamydospore development" EXACT [] +synonym: "chlamydospore development (sensu Candida albicans)" NARROW [] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore +is_a: GO:0048468 ! cell development + +[Term] +id: GO:0001411 +name: hyphal tip +namespace: cellular_component +def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] +subset: goslim_candida +is_a: GO:0030427 ! site of polarized growth + +[Term] +id: GO:0001501 +name: skeletal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jic, GOC:tb, http://www.stedmans.com/] +synonym: "skeletal development" EXACT [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0001502 +name: cartilage condensation +namespace: biological_process +def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0051216 ! cartilage development + +[Term] +id: GO:0001503 +name: ossification +namespace: biological_process +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, http://cancerweb.ncl.ac.uk/] +synonym: "bone biosynthesis" EXACT [] +synonym: "bone formation" EXACT [] +synonym: "osteogenesis" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0001504 +name: neurotransmitter uptake +namespace: biological_process +def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft." [ISBN:0123668387] +synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "neurotransmitter import into glial cell" NARROW [] +synonym: "neurotransmitter import into neuron" NARROW [] +synonym: "neurotransmitter recycling" BROAD [] +synonym: "neurotransmitter reuptake" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0001505 +name: regulation of neurotransmitter levels +namespace: biological_process +def: "Any process that modulates levels of neurotransmitter." [GOC:jl] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0007268 ! synaptic transmission + +[Term] +id: GO:0001506 +name: neurotransmitter biosynthetic process and storage +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] +comment: This term was made obsolete because it is an amalgamation of its two children. +synonym: "neurotransmitter anabolism and storage" EXACT [] +synonym: "neurotransmitter formation and storage" EXACT [] +synonym: "neurotransmitter synthesis and storage" EXACT [] +is_obsolete: true +consider: GO:0042136 +consider: GO:0042137 + +[Term] +id: GO:0001507 +name: acetylcholine catabolic process in synaptic cleft +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] +synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] +synonym: "acetylcholine degradation in synaptic cleft" EXACT [] +is_a: GO:0006581 ! acetylcholine catabolic process +relationship: part_of GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0001508 +name: regulation of action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0042391 ! regulation of membrane potential +relationship: part_of GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0001509 +name: legumain activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] +comment: This term was made obsolete because it represents a gene product. +synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] +synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] +synonym: "citvac" RELATED [EC:3.4.22.34] +synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] +synonym: "phaseolin activity" RELATED [EC:3.4.22.34] +synonym: "proteinase B" RELATED [EC:3.4.22.34] +synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] +synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] +xref: EC:3.4.22.34 +xref: MetaCyc:3.4.22.34-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0001510 +name: RNA methylation +namespace: biological_process +def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] +subset: gosubset_prok +is_a: GO:0009451 ! RNA modification +is_a: GO:0043414 ! biopolymer methylation + +[Term] +id: GO:0001511 +name: fibrillin +namespace: molecular_function +def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0001527 +consider: GO:0005509 + +[Term] +id: GO:0001512 +name: dihydronicotinamide riboside quinone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] +synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] +synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] +synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] +synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] +synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] +synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] +synonym: "NQO2" RELATED [EC:1.10.99.2] +synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] +synonym: "QR2 activity" RELATED [EC:1.10.99.2] +synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] +synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] +xref: EC:1.10.99.2 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0001514 +name: selenocysteine incorporation +namespace: biological_process +def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation, it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] +subset: gosubset_prok +xref: RESID:AA0022 +is_a: GO:0006451 ! translational readthrough + +[Term] +id: GO:0001515 +name: opioid peptide activity +namespace: molecular_function +def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0001516 +name: prostaglandin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] +subset: gosubset_prok +synonym: "prostaglandin anabolism" EXACT [] +synonym: "prostaglandin biosynthesis" EXACT [] +synonym: "prostaglandin formation" EXACT [] +synonym: "prostaglandin synthesis" EXACT [] +is_a: GO:0006693 ! prostaglandin metabolic process +is_a: GO:0046457 ! prostanoid biosynthetic process + +[Term] +id: GO:0001517 +name: N-acetylglucosamine 6-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] +synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0001518 +name: voltage-gated sodium channel complex +namespace: cellular_component +def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "voltage gated sodium channel complex" EXACT [] +synonym: "voltage-dependent sodium channel complex" EXACT [] +synonym: "voltage-sensitive sodium channel complex" EXACT [] +is_a: GO:0034706 ! sodium channel complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0001519 +name: peptide amidation +namespace: biological_process +def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] +subset: gosubset_prok +is_a: GO:0031179 ! peptide modification + +[Term] +id: GO:0001520 +name: outer dense fiber +namespace: cellular_component +def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820] +synonym: "outer dense fibre" EXACT [] +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0001522 +name: pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] +subset: gosubset_prok +synonym: "pseudouridylation" EXACT [] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0001523 +name: retinoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "retinoid metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process + +[Term] +id: GO:0001524 +name: globin +namespace: molecular_function +def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0005344 + +[Term] +id: GO:0001525 +name: angiogenesis +namespace: biological_process +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] +synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0001526 +name: proteoglycan sulfate transfer +namespace: biological_process +def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] +comment: This term was made obsolete because it represents a group of molecular functions. +synonym: "proteoglycan sulphate transfer" EXACT [] +is_obsolete: true +consider: GO:0006029 +consider: GO:0006790 +consider: GO:0050698 + +[Term] +id: GO:0001527 +name: microfibril +namespace: cellular_component +def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235] +synonym: "extended fibrils" EXACT [] +synonym: "fibrillin" RELATED [] +is_a: GO:0043205 ! fibril + +[Term] +id: GO:0001528 +name: elastin +namespace: molecular_function +def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0030023 + +[Term] +id: GO:0001529 +name: elastin +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0030023 + +[Term] +id: GO:0001530 +name: lipopolysaccharide binding +namespace: molecular_function +def: "Interacting selectively with lipopolysaccharide." [PMID:11079463] +synonym: "endotoxin binding" BROAD [] +synonym: "LPS binding" EXACT [] +is_a: GO:0001871 ! pattern binding + +[Term] +id: GO:0001531 +name: interleukin-21 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-21 receptor." [GOC:ai] +synonym: "IL-21" NARROW [] +synonym: "interleukin-21 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0001532 +name: interleukin-21 receptor activity +namespace: molecular_function +def: "Combining with interleukin-21 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-21R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019977 ! interleukin-21 binding + +[Term] +id: GO:0001533 +name: cornified envelope +namespace: cellular_component +def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0001534 +name: radial spoke +namespace: cellular_component +def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0001535 +name: radial spokehead +namespace: cellular_component +def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd] +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part +relationship: part_of GO:0001534 ! radial spoke + +[Term] +id: GO:0001536 +name: radial spoke stalk +namespace: cellular_component +def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part +relationship: part_of GO:0001534 ! radial spoke + +[Term] +id: GO:0001537 +name: N-acetylgalactosamine 4-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] +synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0001539 +name: ciliary or flagellar motility +namespace: biological_process +def: "Cell motility due to movement of cilia or flagella." [GOC:hjd] +subset: gosubset_prok +synonym: "ciliary/flagellar motility" EXACT [] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0001540 +name: beta-amyloid binding +namespace: molecular_function +def: "Interacting selectively with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001541 +name: ovarian follicle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators] +synonym: "follicular phase" RELATED [] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001542 +name: ovulation from ovarian follicle +namespace: biological_process +def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct." [GOC:mtg_sensu, http://ovary.stanford.edu] +synonym: "ovulation (sensu Mammalia)" EXACT [] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0030728 ! ovulation +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001543 +name: ovarian follicle rupture +namespace: biological_process +def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001542 ! ovulation from ovarian follicle + +[Term] +id: GO:0001544 +name: initiation of primordial ovarian follicle growth +namespace: biological_process +def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001545 +name: primary ovarian follicle growth +namespace: biological_process +def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0022605 ! oogenesis stage +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001546 +name: preantral ovarian follicle growth +namespace: biological_process +def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0022605 ! oogenesis stage +relationship: part_of GO:0001541 ! ovarian follicle development +relationship: part_of GO:0048162 ! multi-layer follicle stage, oogenesis + +[Term] +id: GO:0001547 +name: antral ovarian follicle growth +namespace: biological_process +def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001548 +name: follicular fluid formation in ovarian follicle antrum +namespace: biological_process +def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu] +synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] +synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0022605 ! oogenesis stage +relationship: part_of GO:0001547 ! antral ovarian follicle growth + +[Term] +id: GO:0001549 +name: cumulus cell differentiation +namespace: biological_process +def: "The process whereby a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu] +synonym: "ovarian cumulus cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001547 ! antral ovarian follicle growth +relationship: part_of GO:0048165 ! fused antrum stage, oogenesis + +[Term] +id: GO:0001550 +name: ovarian cumulus expansion +namespace: biological_process +def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu] +synonym: "ovarian cumulus growth" RELATED [] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0022605 ! oogenesis stage +relationship: part_of GO:0001547 ! antral ovarian follicle growth +relationship: part_of GO:0048165 ! fused antrum stage, oogenesis + +[Term] +id: GO:0001551 +name: ovarian follicle endowment +namespace: biological_process +def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001552 +name: ovarian follicle atresia +namespace: biological_process +def: "Ovarian follicle demise mediated by apoptosis." [http://ovary.stanford.edu] +is_a: GO:0006915 ! apoptosis +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001553 +name: luteinization +namespace: biological_process +def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu] +synonym: "luteal phase" RELATED [] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001554 +name: luteolysis +namespace: biological_process +def: "Regression of ovarian corpora lutea." [http://ovary.stanford.edu] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001555 +name: oocyte growth +namespace: biological_process +def: "The process by which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0048601 ! oocyte morphogenesis + +[Term] +id: GO:0001556 +name: oocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048599 ! oocyte development + +[Term] +id: GO:0001557 +name: metabolic process resulting in cell growth +namespace: biological_process +def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] +comment: This term was made obsolete because it is redundant with other terms; obsoleted as part of the metabolism rearrangements. +is_obsolete: true +replaced_by: GO:0008152 +replaced_by: GO:0016049 + +[Term] +id: GO:0001558 +name: regulation of cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell growth." [GOC:go_curators] +subset: gosubset_prok +xref: Reactome:110498 +is_a: GO:0040008 ! regulation of growth +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0016049 ! cell growth + +[Term] +id: GO:0001559 +name: regulation of cell growth by detection of nuclear:cytoplasmic ratio +namespace: biological_process +def: "Any process whereby the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] +synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] +synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] +synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] +synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio + +[Term] +id: GO:0001560 +name: regulation of cell growth by extracellular stimulus +namespace: biological_process +def: "Any process whereby external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] +synonym: "interpretation of external signals that regulate cell growth" EXACT [] +synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] +synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] +synonym: "regulation of growth by exogenous signal" EXACT [] +synonym: "regulation of growth by exogenous stimuli" EXACT [] +synonym: "regulation of growth by exogenous stimulus" EXACT [] +synonym: "regulation of growth by external signal" EXACT [] +synonym: "regulation of growth by external stimuli" EXACT [] +synonym: "regulation of growth by external stimulus" EXACT [] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0001561 +name: fatty acid alpha-oxidation +namespace: biological_process +def: "Pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html] +subset: gosubset_prok +xref: MetaCyc:PWY-2501 +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0001562 +name: response to protozoan +namespace: biological_process +alt_id: GO:0042833 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] +synonym: "resistance to pathogenic protozoa" RELATED [] +synonym: "response to protozoa" EXACT [] +synonym: "response to protozoon" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0001563 +name: detection of protozoan +namespace: biological_process +def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] +synonym: "detection of protozoa" EXACT [] +synonym: "detection of protozoon" EXACT [] +synonym: "perception of protozoa" RELATED [] +is_a: GO:0001562 ! response to protozoan +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0001564 +name: resistance to pathogenic protozoa +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0001562 + +[Term] +id: GO:0001565 +name: phorbol ester receptor activity +namespace: molecular_function +def: "Combining with a phorbol ester to initiate a change in cell activity." [GOC:ai, PMID:10506570] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0001566 +name: non-kinase phorbol ester receptor activity +namespace: molecular_function +def: "Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity." [PMID:10506570] +is_a: GO:0001565 ! phorbol ester receptor activity + +[Term] +id: GO:0001567 +name: cholesterol 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O." [EC:1.14.99.38] +synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] +synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] +xref: EC:1.14.99.38 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0001568 +name: blood vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd] +is_a: GO:0001944 ! vasculature development + +[Term] +id: GO:0001569 +name: patterning of blood vessels +namespace: biological_process +def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] +is_a: GO:0009880 ! embryonic pattern specification +is_a: GO:0048754 ! branching morphogenesis of a tube +relationship: part_of GO:0001525 ! angiogenesis + +[Term] +id: GO:0001570 +name: vasculogenesis +namespace: biological_process +def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] +synonym: "vascular morphogenesis" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0001571 +name: non-tyrosine kinase fibroblast growth factor receptor activity +namespace: molecular_function +def: "A receptor belonging to the FGFR family but lacking the tyrosine kinase domain." [PMID:11418238] +synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] +synonym: "non-tyrosine kinase FGFR activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0001572 +name: lactosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471586501] +subset: gosubset_prok +synonym: "lactosylceramide anabolism" EXACT [] +synonym: "lactosylceramide biosynthesis" EXACT [] +synonym: "lactosylceramide formation" EXACT [] +synonym: "lactosylceramide synthesis" EXACT [] +is_a: GO:0046476 ! glycosylceramide biosynthetic process +is_a: GO:0046478 ! lactosylceramide metabolic process + +[Term] +id: GO:0001573 +name: ganglioside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ganglioside metabolism" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0001574 +name: ganglioside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ganglioside anabolism" EXACT [] +synonym: "ganglioside biosynthesis" EXACT [] +synonym: "ganglioside formation" EXACT [] +synonym: "ganglioside synthesis" EXACT [] +is_a: GO:0001573 ! ganglioside metabolic process +is_a: GO:0006688 ! glycosphingolipid biosynthetic process + +[Term] +id: GO:0001575 +name: globoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "globoside metabolism" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0001576 +name: globoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "globoside anabolism" EXACT [] +synonym: "globoside biosynthesis" EXACT [] +synonym: "globoside formation" EXACT [] +synonym: "globoside synthesis" EXACT [] +is_a: GO:0001575 ! globoside metabolic process +is_a: GO:0006688 ! glycosphingolipid biosynthetic process + +[Term] +id: GO:0001577 +name: galectin +namespace: molecular_function +def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "S-type lectin" EXACT [] +is_obsolete: true +consider: GO:0007157 +consider: GO:0016936 + +[Term] +id: GO:0001578 +name: microtubule bundle formation +namespace: biological_process +def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] +synonym: "microtubule bundling" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0001579 +name: medium-chain fatty acid transport +namespace: biological_process +def: "The directed movement of medium-chain fatty acids into, out of, within or between cells. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] +is_a: GO:0015908 ! fatty acid transport + +[Term] +id: GO:0001580 +name: detection of chemical stimulus involved in sensory perception of bitter taste +namespace: biological_process +def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "bitter taste detection" EXACT [] +synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] +synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of bitter taste" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] +synonym: "sensory transduction of bitter taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050913 ! sensory perception of bitter taste + +[Term] +id: GO:0001581 +name: detection of chemical stimulus involved in sensory perception of sour taste +namespace: biological_process +def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] +synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] +synonym: "sensory detection of sour taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] +synonym: "sensory transduction of sour taste" EXACT [] +synonym: "sour taste detection" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050915 ! sensory perception of sour taste + +[Term] +id: GO:0001582 +name: detection of chemical stimulus involved in sensory perception of sweet taste +namespace: biological_process +def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] +synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] +synonym: "sensory detection of sweet taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] +synonym: "sensory transduction of sweet taste" EXACT [] +synonym: "sweet taste detection" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050916 ! sensory perception of sweet taste + +[Term] +id: GO:0001583 +name: detection of chemical stimulus involved in sensory perception of salty taste +namespace: biological_process +def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] +synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "salty taste detection" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] +synonym: "sensory detection of salty taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] +synonym: "sensory transduction of salty taste" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050914 ! sensory perception of salty taste + +[Term] +id: GO:0001584 +name: rhodopsin-like receptor activity +namespace: molecular_function +alt_id: GO:0001620 +def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] +comment: This term was made obsolete because it represents a gene product and is named based on protein features. +subset: gosubset_prok +synonym: "Class A G protein coupled receptor" EXACT [] +synonym: "Class A G-protein coupled receptor" EXACT [] +synonym: "Class A GPCR" EXACT [] +synonym: "class A orphan receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001586 +name: 5-HT1 receptor activity +namespace: molecular_function +is_a: GO:0004993 ! serotonin receptor activity + +[Term] +id: GO:0001587 +name: 5-HT2 receptor activity +namespace: molecular_function +is_a: GO:0004993 ! serotonin receptor activity + +[Term] +id: GO:0001588 +name: dopamine receptor coupled via Gs +namespace: molecular_function +def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033] +is_a: GO:0004952 ! dopamine receptor activity + +[Term] +id: GO:0001589 +name: dopamine D5 receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors." [IUPHAR_RECEPTOR:2260] +is_a: GO:0001588 ! dopamine receptor coupled via Gs + +[Term] +id: GO:0001590 +name: dopamine D1 receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors." [IUPHAR_RECEPTOR:2252] +is_a: GO:0001588 ! dopamine receptor coupled via Gs + +[Term] +id: GO:0001591 +name: dopamine receptor coupled via Gi/Go +namespace: molecular_function +def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033] +is_a: GO:0004952 ! dopamine receptor activity + +[Term] +id: GO:0001592 +name: dopamine D3 receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors." [IUPHAR_RECEPTOR:2256] +is_a: GO:0001591 ! dopamine receptor coupled via Gi/Go + +[Term] +id: GO:0001593 +name: dopamine D4 receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors." [IUPHAR_RECEPTOR:2258] +is_a: GO:0001591 ! dopamine receptor coupled via Gi/Go + +[Term] +id: GO:0001594 +name: trace-amine receptor activity +namespace: molecular_function +is_a: GO:0008227 ! amine receptor activity + +[Term] +id: GO:0001595 +name: angiotensin receptor activity +namespace: molecular_function +def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0001596 +name: angiotensin type I receptor activity +namespace: molecular_function +is_a: GO:0001595 ! angiotensin receptor activity + +[Term] +id: GO:0001597 +name: apelin-like receptor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because the function it represents does not exist. +synonym: "APJ-like receptor" EXACT [] +is_obsolete: true +consider: GO:0031704 + +[Term] +id: GO:0001598 +name: chemokine receptor-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +is_obsolete: true + +[Term] +id: GO:0001599 +name: endothelin-A receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that preferentially binds endothelin 1." [IUPHAR_RECEPTOR:2263, PMID:8582288] +is_a: GO:0004962 ! endothelin receptor activity + +[Term] +id: GO:0001600 +name: endothelin-B receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity." [IUPHAR_RECEPTOR:2265, PMID:8582288] +is_a: GO:0004962 ! endothelin receptor activity + +[Term] +id: GO:0001601 +name: peptide YY receptor activity +namespace: molecular_function +def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] +is_a: GO:0004983 ! neuropeptide Y receptor activity + +[Term] +id: GO:0001602 +name: pancreatic polypeptide receptor activity +namespace: molecular_function +def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] +is_a: GO:0004983 ! neuropeptide Y receptor activity + +[Term] +id: GO:0001603 +name: vasopressin-like receptor activity +namespace: molecular_function +is_obsolete: true + +[Term] +id: GO:0001604 +name: urotensin II receptor activity +namespace: molecular_function +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0001605 +name: adrenomedullin receptor activity +namespace: molecular_function +def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] +synonym: "G10D receptor" NARROW [] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0001606 +name: GPR37/endothelin B-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +is_obsolete: true + +[Term] +id: GO:0001607 +name: neuromedin U receptor activity +namespace: molecular_function +def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] +synonym: "NMUR activity" EXACT [] +is_a: GO:0008188 ! neuropeptide receptor activity +is_a: GO:0042924 ! neuromedin U binding + +[Term] +id: GO:0001608 +name: nucleotide receptor activity, G-protein coupled +namespace: molecular_function +def: "A GPCR that binds a nucleotide or nucleotide derivative as its ligand." [GOC:dph, IUPHAR_GPCR:1294] +synonym: "G protein coupled nucleotide receptor activity" EXACT [] +synonym: "G-protein-coupled nucleotide receptor activity" EXACT [] +synonym: "nucleotide receptor activity, G protein coupled" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001609 +name: adenosine receptor activity, G-protein coupled +namespace: molecular_function +alt_id: GO:0001610 +alt_id: GO:0001611 +alt_id: GO:0001612 +alt_id: GO:0001613 +alt_id: GO:0008501 +def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] +synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "adenosine nucleotide receptor" BROAD [] +synonym: "adenosine receptor activity, G protein coupled" EXACT [] +synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] +synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] +synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] +synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] +synonym: "G protein coupled adenosine receptor activity" EXACT [] +synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled adenosine receptor activity" EXACT [] +is_a: GO:0045028 ! purinergic nucleotide receptor activity, G-protein coupled + +[Term] +id: GO:0001614 +name: purinergic nucleotide receptor activity +namespace: molecular_function +def: "Combining with a purine nucleotide to initiate a change in cell activity." [GOC:mah] +synonym: "P2Y receptor" NARROW [] +synonym: "purinoceptor" BROAD [] +synonym: "purinoreceptor" BROAD [] +is_a: GO:0016502 ! nucleotide receptor activity + +[Term] +id: GO:0001615 +name: thyrotropin releasing hormone and secretagogue-like receptors activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +is_obsolete: true + +[Term] +id: GO:0001616 +name: growth hormone secretagogue receptor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001617 +name: growth hormone secretagogue-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +is_obsolete: true + +[Term] +id: GO:0001618 +name: viral receptor activity +namespace: molecular_function +def: "Combining with a virus component to initiate a change in cell activity." [GOC:dph] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0001619 +name: lysosphingolipid and lysophosphatidic acid receptor activity +namespace: molecular_function +def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] +is_a: GO:0045125 ! bioactive lipid receptor activity + +[Term] +id: GO:0001621 +name: platelet ADP receptor activity +namespace: molecular_function +synonym: "K101 receptor" NARROW [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001622 +name: super conserved receptor expressed in brain receptor activity +namespace: molecular_function +synonym: "SREB receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001623 +name: Mas proto-oncogene receptor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001624 +name: RDC1 receptor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001625 +name: Epstein-Barr Virus-induced receptor activity +namespace: molecular_function +synonym: "EBV-induced receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001626 +name: nociceptin/orphanin-FQ receptor activity +namespace: molecular_function +synonym: "ORPH receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001627 +name: leucine-rich G-protein receptor-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] +synonym: "LGR-like receptor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001628 +name: gastropyloric receptor activity +namespace: molecular_function +synonym: "GPR receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001629 +name: G-protein receptor 45-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "G protein receptor 45-like receptor activity" EXACT [] +synonym: "GPR45-like receptor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001630 +name: GP40-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +is_obsolete: true + +[Term] +id: GO:0001631 +name: cysteinyl leukotriene receptor activity +namespace: molecular_function +def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "CysLT receptor" EXACT [] +is_a: GO:0004974 ! leukotriene receptor activity + +[Term] +id: GO:0001632 +name: leukotriene B4 receptor activity +namespace: molecular_function +def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "BLT receptor" NARROW [] +is_a: GO:0004974 ! leukotriene receptor activity + +[Term] +id: GO:0001633 +name: secretin-like receptor activity +namespace: molecular_function +alt_id: GO:0001638 +def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506] +comment: This term was made obsolete because it represents a gene product and is named based on protein features. +synonym: "class B G protein coupled receptor" EXACT [] +synonym: "class B G-protein coupled receptor" EXACT [] +synonym: "class B GPCR" EXACT [] +synonym: "class B orphan receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001634 +name: pituitary adenylate cyclase activating protein receptor activity +namespace: molecular_function +alt_id: GO:0016522 +synonym: "PACAP receptor" EXACT [] +synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] +synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001635 +name: calcitonin gene-related polypeptide receptor activity +namespace: molecular_function +synonym: "CGRP receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0001636 +name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +is_obsolete: true + +[Term] +id: GO:0001637 +name: G-protein chemoattractant receptor activity +namespace: molecular_function +synonym: "G protein chemoattractant receptor activity" EXACT [] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0001639 +name: PLC activating metabotropic glutamate receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] +synonym: "Group I metabotropic glutamate receptor" RELATED [] +synonym: "group I metabotropic glutamate receptor activity" RELATED [] +synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] +is_a: GO:0008066 ! glutamate receptor activity + +[Term] +id: GO:0001640 +name: adenylate cyclase inhibiting metabotropic glutamate receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity." [GOC:dph] +synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] +is_a: GO:0008066 ! glutamate receptor activity + +[Term] +id: GO:0001641 +name: group II metabotropic glutamate receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] +is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity + +[Term] +id: GO:0001642 +name: group III metabotropic glutamate receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] +is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity + +[Term] +id: GO:0001646 +name: cAMP receptor activity +namespace: molecular_function +alt_id: GO:0001644 +def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity." [GOC:pg] +synonym: "3',5' cAMP receptor activity" EXACT [] +synonym: "3',5'-cAMP receptor activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] +synonym: "class E G protein coupled receptor" BROAD [] +synonym: "class E G-protein coupled receptor" BROAD [] +synonym: "class E GPCR" BROAD [] +synonym: "cyclic AMP receptor activity" EXACT [] +is_a: GO:0016502 ! nucleotide receptor activity +is_a: GO:0030552 ! cAMP binding + +[Term] +id: GO:0001647 +name: G-protein coupled cytokinin receptor activity +namespace: molecular_function +def: "Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled." [GOC:dph] +synonym: "G protein coupled cytokinin receptor activity" EXACT [] +synonym: "G-protein-coupled cytokinin receptor activity" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity +is_a: GO:0009884 ! cytokinin receptor activity + +[Term] +id: GO:0001648 +name: proteinase activated receptor activity +namespace: molecular_function +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0001649 +name: osteoblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "osteoblast cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001503 ! ossification + +[Term] +id: GO:0001650 +name: fibrillar center +namespace: cellular_component +def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] +synonym: "fibrillar centre" EXACT [] +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0001651 +name: dense fibrillar component +namespace: cellular_component +def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0001652 +name: granular component +namespace: cellular_component +def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0001653 +name: peptide receptor activity +namespace: molecular_function +def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] +synonym: "endogenous peptide receptor activity" NARROW [] +synonym: "exogenous peptide receptor activity" NARROW [] +is_a: GO:0004872 ! receptor activity +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0001654 +name: eye development +namespace: biological_process +alt_id: GO:0042460 +def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jic, GOC:jl] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0001655 +name: urogenital system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0001656 +name: metanephros development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is the excretory organ of the fetus which develops into the kidney and is formed from the rear portion of the nephrogenic cord." [ISBN:0192800752] +is_a: GO:0001822 ! kidney development + +[Term] +id: GO:0001657 +name: ureteric bud development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0001658 +name: ureteric bud branching +namespace: biological_process +def: "Branching of the ureteric bud." [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of a tube +relationship: part_of GO:0001657 ! ureteric bud development + +[Term] +id: GO:0001659 +name: temperature homeostasis +namespace: biological_process +def: "A homeostatic process by which an organism modulates its internal body temperature." [GOC:jl] +synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0001660 +name: fever +namespace: biological_process +def: "A rise in body temperature above the normal, often as a response to infection." [GOC:jl] +synonym: "pyrexia" BROAD [] +is_a: GO:0006953 ! acute-phase response +is_a: GO:0031649 ! heat generation + +[Term] +id: GO:0001661 +name: conditioned taste aversion +namespace: biological_process +def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0008306 ! associative learning + +[Term] +id: GO:0001662 +name: behavioral fear response +namespace: biological_process +def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] +synonym: "behavioural fear response" EXACT [] +is_a: GO:0002209 ! behavioral defense response +is_a: GO:0042596 ! fear response + +[Term] +id: GO:0001664 +name: G-protein-coupled receptor binding +namespace: molecular_function +def: "Interacting selectively with a G-protein-coupled receptor." [GOC:ceb, GOC:dph] +synonym: "G protein coupled receptor binding" EXACT [] +synonym: "G protein coupled receptor ligand" NARROW [] +synonym: "G-protein-coupled receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0001665 +name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] +synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] +synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] +xref: EC:2.4.99.3 +xref: MetaCyc:2.4.99.3-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0001666 +name: response to hypoxia +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] +comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. +synonym: "response to hypoxic stress" EXACT [] +synonym: "response to lowered oxygen tension" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0001667 +name: ameboidal cell migration +namespace: biological_process +def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] +synonym: "ameboid cell migration" EXACT [] +synonym: "amoeboid cell migration" EXACT [] +synonym: "amoeboidal cell migration" EXACT [] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0001669 +name: acrosome +namespace: cellular_component +def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0001670 +name: dopamine D2 receptor activity +namespace: molecular_function +def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors." [IUPHAR_RECEPTOR:2254] +is_a: GO:0001591 ! dopamine receptor coupled via Gi/Go + +[Term] +id: GO:0001671 +name: ATPase activator activity +namespace: molecular_function +def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp] +synonym: "ATPase stimulator activity" EXACT [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0001672 +name: regulation of chromatin assembly or disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] +synonym: "regulation of chromatin assembly/disassembly" EXACT [] +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0006333 ! chromatin assembly or disassembly + +[Term] +id: GO:0001673 +name: male germ cell nucleus +namespace: cellular_component +alt_id: GO:0043081 +def: "The nucleus of a male germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:hjd, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk] +synonym: "male germ cell nucleus (sensu Metazoa)" EXACT [] +synonym: "male germ-cell nucleus" EXACT [] +synonym: "male germ-cell nucleus (sensu Metazoa)" EXACT [] +is_a: GO:0043073 ! germ cell nucleus + +[Term] +id: GO:0001674 +name: female germ cell nucleus +namespace: cellular_component +alt_id: GO:0043080 +def: "The nucleus of the female germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:hjd, http://cancerweb.ncl.ac.uk] +synonym: "female germ cell nucleus (sensu Metazoa)" EXACT [] +synonym: "female germ-cell nucleus" EXACT [] +synonym: "female germ-cell nucleus (sensu Animalia)" EXACT [] +is_a: GO:0043073 ! germ cell nucleus + +[Term] +id: GO:0001675 +name: acrosome formation +namespace: biological_process +def: "The formation of the acrosome from the spermatid Golgi." [GOC:hjd] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0001676 +name: long-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:ajp] +subset: gosubset_prok +synonym: "long-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0001677 +name: formation of translation initiation ternary complex +namespace: biological_process +def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] +subset: gosubset_prok +synonym: "translation initiation ternary complex assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0006413 ! translational initiation + +[Term] +id: GO:0001678 +name: cellular glucose homeostasis +namespace: biological_process +def: "A cellular homeostatic process involved in the maintenance of an internal equilibrium of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042593 ! glucose homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0001680 +name: tRNA 3'-terminal CCA addition +namespace: biological_process +def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0042780 ! tRNA 3'-end processing + +[Term] +id: GO:0001681 +name: sialate O-acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] +subset: gosubset_prok +synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] +synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] +synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] +xref: EC:3.1.1.53 +xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN +is_a: GO:0008126 ! acetylesterase activity + +[Term] +id: GO:0001682 +name: tRNA 5'-leader removal +namespace: biological_process +def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] +subset: gosubset_prok +synonym: "tRNA 5' leader removal" EXACT [] +is_a: GO:0008033 ! tRNA processing + +[Term] +id: GO:0001683 +name: axonemal dynein heavy chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001684 +name: axonemal dynein intermediate chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001685 +name: axonemal dynein intermediate light chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001686 +name: axonemal dynein light chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001687 +name: cytoplasmic dynein heavy chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001688 +name: cytoplasmic dynein intermediate chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001689 +name: cytoplasmic dynein intermediate light chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001690 +name: cytoplasmic dynein light chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001691 +name: pseudophosphatase activity +namespace: molecular_function +def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] +is_a: GO:0019212 ! phosphatase inhibitor activity + +[Term] +id: GO:0001692 +name: histamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] +synonym: "histamine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0001694 +name: histamine biosynthetic process +namespace: biological_process +alt_id: GO:0001693 +def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] +synonym: "histamine anabolism" EXACT [] +synonym: "histamine biosynthesis" EXACT [] +synonym: "histamine formation" EXACT [] +synonym: "histamine synthesis" EXACT [] +is_a: GO:0001692 ! histamine metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0001695 +name: histamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] +synonym: "histamine breakdown" EXACT [] +synonym: "histamine catabolism" EXACT [] +synonym: "histamine degradation" EXACT [] +is_a: GO:0001692 ! histamine metabolic process +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:0042402 ! biogenic amine catabolic process +is_a: GO:0046700 ! heterocycle catabolic process + +[Term] +id: GO:0001696 +name: gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] +synonym: "hydrochloric acid secretion" NARROW [] +is_a: GO:0022600 ! digestive system process +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0001697 +name: histamine-induced gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] +is_a: GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0001698 +name: gastrin-induced gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] +is_a: GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0001699 +name: acetylcholine-induced gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] +is_a: GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0001700 +name: embryonic development via the syncytial blastoderm +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva." [GOC:go_curators, GOC:mtg_sensu] +synonym: "embryonic development (sensu Insecta)" EXACT [] +is_a: GO:0009792 ! embryonic development ending in birth or egg hatching + +[Term] +id: GO:0001701 +name: in utero embryonic development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth." [GOC:go_curators, GOC:mtg_sensu] +synonym: "embryonic development (sensu Mammalia)" EXACT [] +is_a: GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0001702 +name: gastrulation with mouth forming second +namespace: biological_process +alt_id: GO:0010003 +alt_id: GO:0048276 +def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. In Deuterostomes the initial blastopore becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] +synonym: "gastrulation (sensu Deuterostomia)" EXACT [] +synonym: "gastrulation (sensu Mammalia)" NARROW [] +synonym: "gastrulation (sensu Vertebrata)" NARROW [] +is_a: GO:0007369 ! gastrulation + +[Term] +id: GO:0001703 +name: gastrulation with mouth forming first +namespace: biological_process +def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. In Protostomes the initial blastopore becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] +synonym: "gastrulation (sensu Protostomia)" EXACT [] +is_a: GO:0007369 ! gastrulation + +[Term] +id: GO:0001704 +name: formation of primary germ layer +namespace: biological_process +def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0001705 +name: ectoderm formation +namespace: biological_process +def: "The formation of ectoderm during gastrulation." [GOC:go_curators] +is_a: GO:0001704 ! formation of primary germ layer +relationship: part_of GO:0007398 ! ectoderm development + +[Term] +id: GO:0001706 +name: endoderm formation +namespace: biological_process +def: "The formation of the endoderm during gastrulation." [GOC:go_curators] +is_a: GO:0001704 ! formation of primary germ layer +relationship: part_of GO:0007492 ! endoderm development + +[Term] +id: GO:0001707 +name: mesoderm formation +namespace: biological_process +def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] +is_a: GO:0001704 ! formation of primary germ layer +relationship: part_of GO:0048332 ! mesoderm morphogenesis + +[Term] +id: GO:0001708 +name: cell fate specification +namespace: biological_process +def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0001709 +name: cell fate determination +namespace: biological_process +def: "Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0001710 +name: mesodermal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] +synonym: "mesoderm cell fate commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0048333 ! mesodermal cell differentiation + +[Term] +id: GO:0001711 +name: endodermal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] +synonym: "endoderm cell fate commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment + +[Term] +id: GO:0001712 +name: ectodermal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] +synonym: "ectoderm cell fate commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0010668 ! ectodermal cell differentiation + +[Term] +id: GO:0001713 +name: ectodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] +synonym: "ectoderm cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0001712 ! ectodermal cell fate commitment + +[Term] +id: GO:0001714 +name: endodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +synonym: "endoderm cell fate specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0001711 ! endodermal cell fate commitment + +[Term] +id: GO:0001715 +name: ectodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +synonym: "ectoderm cell fate specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0001712 ! ectodermal cell fate commitment + +[Term] +id: GO:0001716 +name: L-amino-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.2] +subset: gosubset_prok +synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] +synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] +xref: EC:1.4.3.2 +xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0001717 +name: conversion of seryl-tRNAsec to selenocys-tRNAsec +namespace: biological_process +def: "Process whereby serine carried by a specialized tRNA(ser) (which can read a UGA anticodon) is converted to selenocysteine." [ISBN:155581073X] +subset: gosubset_prok +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0001718 +name: conversion of met-tRNAf to fmet-tRNA +namespace: biological_process +def: "The process whereby methionine carried by an initiator methionine tRNA is N-formylated." [ISBN:155581073X] +subset: gosubset_prok +synonym: "N-terminal peptidyl-methionine N-formylation" EXACT [] +is_a: GO:0018004 ! N-terminal protein formylation +is_a: GO:0019988 ! charged-tRNA amino acid modification +relationship: part_of GO:0006413 ! translational initiation + +[Term] +id: GO:0001720 +name: conversion of lysyl-tRNA to pyrrolysyl-tRNA +namespace: biological_process +def: "Process whereby lysine carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon) is converted to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] +subset: gosubset_prok +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0001721 +name: intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "IFAP" EXACT [] +is_obsolete: true +replaced_by: GO:0005882 + +[Term] +id: GO:0001722 +name: type I intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005882 + +[Term] +id: GO:0001723 +name: type II intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005882 + +[Term] +id: GO:0001724 +name: type III intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0045098 + +[Term] +id: GO:0001725 +name: stress fiber +namespace: cellular_component +def: "Bundle of microfilaments and other proteins found in fibroblasts." [ISBN:0124325653] +synonym: "stress fibre" EXACT [] +is_a: GO:0032432 ! actin filament bundle + +[Term] +id: GO:0001726 +name: ruffle +namespace: cellular_component +def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] +synonym: "membrane ruffle" RELATED [] +is_a: GO:0042995 ! cell projection +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0001727 +name: lipid kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] +subset: gosubset_prok +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0001729 +name: ceramide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide 1-phosphate." [EC:2.7.1.138] +synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] +synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] +xref: EC:2.7.1.138 +xref: MetaCyc:CERAMIDE-KINASE-RXN +is_a: GO:0001727 ! lipid kinase activity + +[Term] +id: GO:0001730 +name: 2'-5'-oligoadenylate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. Requires binding of double-stranded RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "(2-5')oligo(A) synthetase activity" EXACT [] +synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] +synonym: "2-5A synthetase activity" EXACT [] +synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0001731 +name: formation of translation preinitiation complex +namespace: biological_process +def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] +comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0016283', and their children. +subset: gosubset_prok +synonym: "formation of translation pre-initiation complex" EXACT [] +synonym: "translation preinitiation complex assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0006413 ! translational initiation + +[Term] +id: GO:0001732 +name: formation of translation initiation complex +namespace: biological_process +def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] +subset: gosubset_prok +synonym: "translation initiation complex assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0006413 ! translational initiation + +[Term] +id: GO:0001733 +name: galactosylceramide sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] +synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] +synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] +synonym: "cerebroside sulfotransferase activity" EXACT [] +synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] +synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] +synonym: "galactosylceramide sulphotransferase activity" EXACT [] +synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] +synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] +synonym: "GSase" EXACT [EC:2.8.2.11] +xref: EC:2.8.2.11 +xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN +is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity + +[Term] +id: GO:0001734 +name: mRNA (N6-adenosine)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R = purine, and H = C, A, or U." [GOC:hjd] +xref: Reactome:2399 +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0001735 +name: prenylcysteine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H20 = a prenal + L-cysteine + H202." [GOC:hjd] +synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] +synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] +xref: EC:1.8.3.5 +xref: MetaCyc:1.8.3.5-RXN +is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0001736 +name: establishment of planar polarity +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] +synonym: "establishment of planar cell polarity" NARROW [] +is_a: GO:0007164 ! establishment of tissue polarity +relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium + +[Term] +id: GO:0001737 +name: establishment of imaginal disc-derived wing hair orientation +namespace: biological_process +def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:mtg_sensu, PMID:11239465] +synonym: "establishment of wing hair orientation" EXACT [] +is_a: GO:0001736 ! establishment of planar polarity +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0001738 +name: morphogenesis of a polarized epithelium +namespace: biological_process +def: "The process by which the anatomical structures of polarized epithelium are generated and organized. Morphogenesis pertains to the creation of form. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0001739 +name: sex chromatin +namespace: cellular_component +def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005720 ! nuclear heterochromatin +relationship: part_of GO:0000803 ! sex chromosome + +[Term] +id: GO:0001740 +name: Barr body +namespace: cellular_component +def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] +is_a: GO:0000805 ! X chromosome +is_a: GO:0001739 ! sex chromatin + +[Term] +id: GO:0001741 +name: XY body +namespace: cellular_component +def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] +is_a: GO:0001739 ! sex chromatin + +[Term] +id: GO:0001742 +name: oenocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] +synonym: "oenocyte cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0001743 +name: optic placode formation +namespace: biological_process +def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0001744 +name: optic lobe placode formation +namespace: biological_process +alt_id: GO:0007457 +def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] +synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] +synonym: "optic lobe placode formation (sensu Drosophila)" EXACT [] +synonym: "optic placode formation (sensu Endopterygota)" EXACT [] +is_a: GO:0001743 ! optic placode formation +relationship: part_of GO:0001748 ! optic lobe placode development + +[Term] +id: GO:0001745 +name: compound eye morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the compound eye are generated and organized. Morphogenesis pertains to the creation of form. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position." [GOC:dph, GOC:mtg_sensu] +synonym: "compound eye morphogenesis (sensu Endopterygota)" EXACT [] +synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] +is_a: GO:0048592 ! eye morphogenesis +relationship: part_of GO:0048749 ! compound eye development + +[Term] +id: GO:0001746 +name: Bolwig's organ morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the larval eye in Drosophila are generated and organized. Morphogenesis pertains to the creation of form. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] +is_a: GO:0048592 ! eye morphogenesis +relationship: part_of GO:0055034 ! Bolwig's organ development + +[Term] +id: GO:0001748 +name: optic lobe placode development +namespace: biological_process +alt_id: GO:0048049 +def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe." [GOC:mtg_sensu, PMID:8402833] +synonym: "embryonic eye morphogenesis (sensu Endopterygota)" EXACT [] +synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] +synonym: "optic placode development (sensu Endopterygota)" EXACT [] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0001750 +name: photoreceptor outer segment +namespace: cellular_component +def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820] +is_a: GO:0031513 ! nonmotile primary cilium + +[Term] +id: GO:0001751 +name: compound eye photoreceptor cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] +synonym: "eye photoreceptor cell differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0001754 ! eye photoreceptor cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0001752 +name: compound eye photoreceptor fate commitment +namespace: biological_process +alt_id: GO:0007459 +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +synonym: "eye photoreceptor fate commitment (sensu Endopterygota)" EXACT [] +synonym: "photoreceptor fate commitment (sensu Endopterygota)" EXACT [] +is_a: GO:0042706 ! eye photoreceptor cell fate commitment +relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0001753 +name: adult eye photoreceptor development (sensu Drosophila) +namespace: biological_process +def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] +comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. +is_obsolete: true +consider: GO:0042051 + +[Term] +id: GO:0001754 +name: eye photoreceptor cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] +is_a: GO:0046530 ! photoreceptor cell differentiation +relationship: part_of GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0001755 +name: neural crest cell migration +namespace: biological_process +def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [ISBN:0878932437] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0014032 ! neural crest cell development + +[Term] +id: GO:0001756 +name: somitogenesis +namespace: biological_process +def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] +is_a: GO:0009952 ! anterior/posterior pattern formation +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0001757 +name: somite specification +namespace: biological_process +def: "The process by which individual somites establish identity during embryogenesis." [GOC:dph] +is_a: GO:0007379 ! segment specification +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0001758 +name: retinal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] +synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] +synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] +xref: EC:1.2.1.36 +xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0001759 +name: induction of an organ +namespace: biological_process +def: "The close range interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] +is_a: GO:0010092 ! specification of organ identity +is_a: GO:0031128 ! induction + +[Term] +id: GO:0001760 +name: aminocarboxymuconate-semialdehyde decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2." [EC:4.1.1.45] +subset: gosubset_prok +synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] +synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] +synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] +synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] +synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] +synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] +synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] +xref: EC:4.1.1.45 +xref: MetaCyc:4.1.1.45-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0001761 +name: beta-alanine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] +synonym: "beta-alanine transporter activity" BROAD [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0001762 +name: beta-alanine transport +namespace: biological_process +def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of, within or between cells." [GOC:hjd] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0001763 +name: morphogenesis of a branching structure +namespace: biological_process +def: "The process by which the anatomical structures of branches are generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0001764 +name: neuron migration +namespace: biological_process +def: "The characteristic movement of immature neurons from germinal zones to specific positions where they will reside as they mature." [GOC:go_curators] +synonym: "neuronal migration" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0001765 +name: membrane raft formation +namespace: biological_process +def: "Formation of a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] +synonym: "lipid raft formation" EXACT [] +is_a: GO:0031579 ! membrane raft organization + +[Term] +id: GO:0001766 +name: membrane raft polarization +namespace: biological_process +def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889] +synonym: "lipid raft polarization" EXACT [] +is_a: GO:0031580 ! membrane raft distribution + +[Term] +id: GO:0001767 +name: establishment of lymphocyte polarity +namespace: biological_process +def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] +synonym: "lymphocyte polarization" EXACT [] +is_a: GO:0030010 ! establishment of cell polarity +relationship: part_of GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0001768 +name: establishment of T cell polarity +namespace: biological_process +def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] +synonym: "establishment of T lymphocyte polarity" EXACT [] +synonym: "establishment of T-cell polarity" EXACT [] +synonym: "establishment of T-lymphocyte polarity" EXACT [] +synonym: "T cell polarization" EXACT [] +synonym: "T lymphocyte polarization" EXACT [] +synonym: "T-cell polarization" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +relationship: part_of GO:0042110 ! T cell activation + +[Term] +id: GO:0001769 +name: establishment of B cell polarity +namespace: biological_process +def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] +comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. +synonym: "B cell polarization" EXACT [] +synonym: "B lymphocyte polarization" EXACT [] +synonym: "B-cell polarization" EXACT [] +synonym: "establishment of B lymphocyte polarity" EXACT [] +synonym: "establishment of B-cell polarity" EXACT [] +synonym: "establishment of B-lymphocyte polarity" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +relationship: part_of GO:0042113 ! B cell activation + +[Term] +id: GO:0001770 +name: establishment of natural killer cell polarity +namespace: biological_process +def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] +synonym: "establishment of NK cell polarity" EXACT [] +synonym: "natural killer cell polarization" EXACT [] +synonym: "NK cell polarization" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +relationship: part_of GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0001771 +name: formation of immunological synapse +namespace: biological_process +def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] +is_a: GO:0009988 ! cell-cell recognition +relationship: part_of GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0001772 +name: immunological synapse +namespace: cellular_component +def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] +synonym: "c-SMAC" NARROW [PMID:14724296] +synonym: "supramolecular activation cluster" EXACT [PMID:14724296] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0001773 +name: myeloid dendritic cell activation +namespace: biological_process +def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0001774 +name: microglial cell activation +namespace: biological_process +def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] +is_a: GO:0042116 ! macrophage activation + +[Term] +id: GO:0001775 +name: cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0001776 +name: leukocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. +synonym: "immune cell homeostasis" EXACT [] +synonym: "leucocyte homeostasis" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0001777 +name: T cell homeostatic proliferation +namespace: biological_process +def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +synonym: "resting T cell proliferation" EXACT [] +synonym: "resting T-cell proliferation" EXACT [] +synonym: "T lymphocyte homeostatic proliferation" EXACT [] +synonym: "T-cell homeostatic proliferation" EXACT [] +synonym: "T-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation +relationship: part_of GO:0043029 ! T cell homeostasis + +[Term] +id: GO:0001778 +name: plasma membrane repair +namespace: biological_process +def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] +is_a: GO:0007009 ! plasma membrane organization +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0001779 +name: natural killer cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "NK cell differentiation" EXACT [] +is_a: GO:0030098 ! lymphocyte differentiation +is_a: GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0001780 +name: neutrophil homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:12752675, PMID:12960266] +comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0001781 +name: neutrophil apoptosis +namespace: biological_process +def: "The process of apoptosis in neutrophils." [GOC:add, PMID:12752675, PMID:12960266] +synonym: "apoptosis of neutrophils" EXACT [] +synonym: "neutrophil programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] +synonym: "programmed cell death, neutrophils" EXACT [] +is_a: GO:0033028 ! myeloid cell apoptosis +relationship: part_of GO:0001780 ! neutrophil homeostasis + +[Term] +id: GO:0001782 +name: B cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12956429] +comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. +synonym: "B lymphocyte homeostasis" EXACT [] +synonym: "B-cell homeostasis" EXACT [] +synonym: "B-lymphocyte homeostasis" EXACT [] +is_a: GO:0002260 ! lymphocyte homeostasis + +[Term] +id: GO:0001783 +name: B cell apoptosis +namespace: biological_process +def: "The process of apoptosis in B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "apoptosis of B cells" EXACT [] +synonym: "apoptosis of B lymphocytes" EXACT [] +synonym: "apoptosis of B-cells" EXACT [] +synonym: "apoptosis of B-lymphocytes" EXACT [] +synonym: "B cell programmed cell death by apoptosis" EXACT [] +synonym: "B lymphocyte apoptosis" EXACT [] +synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "B-cell apoptosis" EXACT [] +synonym: "B-cell programmed cell death by apoptosis" EXACT [] +synonym: "B-lymphocyte apoptosis" EXACT [] +synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of B cells by apoptosis" EXACT [] +synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death of B-cells by apoptosis" EXACT [] +synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death, B cells" EXACT [] +synonym: "programmed cell death, B lymphocytes" EXACT [] +synonym: "programmed cell death, B-cells" EXACT [] +synonym: "programmed cell death, B-lymphocytes" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0001784 +name: phosphotyrosine binding +namespace: molecular_function +def: "Interacting selectively with a phosphorylated tyrosine residue within a protein." [PMID:14636584] +is_a: GO:0045309 ! protein phosphorylated amino acid binding + +[Term] +id: GO:0001785 +name: prostaglandin J receptor activity +namespace: molecular_function +def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] +synonym: "PGJ receptor activity" RELATED [] +synonym: "PGJ(2) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0001786 +name: phosphatidylserine binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12000961] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0001787 +name: natural killer cell proliferation +namespace: biological_process +def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "NK cell proliferation" EXACT [] +is_a: GO:0030101 ! natural killer cell activation +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0001788 +name: antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [ISBN:0781735149 "Fundamental Immunology", PMID:11677095, PMID:9581795] +synonym: "ADCC" EXACT [] +synonym: "antibody dependent cell death" EXACT [] +synonym: "antibody dependent cell killing" EXACT [] +synonym: "antibody-dependent cell death" EXACT [] +synonym: "antibody-dependent cell killing" EXACT [] +synonym: "type VI hypersensitivity" EXACT [] +is_a: GO:0001794 ! type IIa hypersensitivity +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0006917 ! induction of apoptosis + +[Term] +id: GO:0001789 +name: G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) +namespace: biological_process +def: "A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate." [GOC:dph, PMID:14592418] +synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] +synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] +synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0001790 +name: polymeric immunoglobulin binding +namespace: molecular_function +def: "Interacting selectively with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0001791 +name: IgM binding +namespace: molecular_function +def: "Interacting selectively with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0001792 +name: polymeric immunoglobulin receptor activity +namespace: molecular_function +def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001790 ! polymeric immunoglobulin binding +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0001793 +name: IgM receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001791 ! IgM binding +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0001794 +name: type IIa hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. +is_a: GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0001795 +name: type IIb hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. +synonym: "type V hypersensitivity" EXACT [] +is_a: GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0001796 +name: regulation of type IIa hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: regulates GO:0001794 ! type IIa hypersensitivity + +[Term] +id: GO:0001797 +name: negative regulation of type IIa hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of type IIa hypersensitivity" EXACT [] +synonym: "down-regulation of type IIa hypersensitivity" EXACT [] +synonym: "downregulation of type IIa hypersensitivity" EXACT [] +synonym: "inhibition of type IIa hypersensitivity" NARROW [] +is_a: GO:0001796 ! regulation of type IIa hypersensitivity +is_a: GO:0002893 ! negative regulation of type II hypersensitivity +relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity + +[Term] +id: GO:0001798 +name: positive regulation of type IIa hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of type IIa hypersensitivity" NARROW [] +synonym: "stimulation of type IIa hypersensitivity" NARROW [] +synonym: "up regulation of type IIa hypersensitivity" EXACT [] +synonym: "up-regulation of type IIa hypersensitivity" EXACT [] +synonym: "upregulation of type IIa hypersensitivity" EXACT [] +is_a: GO:0001796 ! regulation of type IIa hypersensitivity +is_a: GO:0002894 ! positive regulation of type II hypersensitivity +relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity + +[Term] +id: GO:0001799 +name: regulation of type IIb hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: regulates GO:0001795 ! type IIb hypersensitivity + +[Term] +id: GO:0001800 +name: negative regulation of type IIb hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of type IIb hypersensitivity" EXACT [] +synonym: "down-regulation of type IIb hypersensitivity" EXACT [] +synonym: "downregulation of type IIb hypersensitivity" EXACT [] +synonym: "inhibition of type IIb hypersensitivity" NARROW [] +is_a: GO:0001799 ! regulation of type IIb hypersensitivity +is_a: GO:0002893 ! negative regulation of type II hypersensitivity +relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity + +[Term] +id: GO:0001801 +name: positive regulation of type IIb hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of type IIb hypersensitivity" NARROW [] +synonym: "stimulation of type IIb hypersensitivity" NARROW [] +synonym: "up regulation of type IIb hypersensitivity" EXACT [] +synonym: "up-regulation of type IIb hypersensitivity" EXACT [] +synonym: "upregulation of type IIb hypersensitivity" EXACT [] +is_a: GO:0001799 ! regulation of type IIb hypersensitivity +is_a: GO:0002894 ! positive regulation of type II hypersensitivity +relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity + +[Term] +id: GO:0001802 +name: type III hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that the Arthus reaction is an example of type III hypersensitivity. +is_a: GO:0002444 ! myeloid leukocyte mediated immunity +is_a: GO:0002524 ! hypersensitivity +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0001803 +name: regulation of type III hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002883 ! regulation of hypersensitivity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0001802 ! type III hypersensitivity + +[Term] +id: GO:0001804 +name: negative regulation of type III hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of type III hypersensitivity" EXACT [] +synonym: "down-regulation of type III hypersensitivity" EXACT [] +synonym: "downregulation of type III hypersensitivity" EXACT [] +synonym: "inhibition of type III hypersensitivity" NARROW [] +is_a: GO:0001803 ! regulation of type III hypersensitivity +is_a: GO:0002884 ! negative regulation of hypersensitivity +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +relationship: negatively_regulates GO:0001802 ! type III hypersensitivity + +[Term] +id: GO:0001805 +name: positive regulation of type III hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of type III hypersensitivity" NARROW [] +synonym: "stimulation of type III hypersensitivity" NARROW [] +synonym: "up regulation of type III hypersensitivity" EXACT [] +synonym: "up-regulation of type III hypersensitivity" EXACT [] +synonym: "upregulation of type III hypersensitivity" EXACT [] +is_a: GO:0001803 ! regulation of type III hypersensitivity +is_a: GO:0002885 ! positive regulation of hypersensitivity +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +relationship: positively_regulates GO:0001802 ! type III hypersensitivity + +[Term] +id: GO:0001806 +name: type IV hypersensitivity +namespace: biological_process +alt_id: GO:0016069 +def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "delayed hypersensitivity response" EXACT [] +synonym: "delayed-type hypersensitivity" EXACT [] +is_a: GO:0002456 ! T cell mediated immunity +is_a: GO:0002524 ! hypersensitivity + +[Term] +id: GO:0001807 +name: regulation of type IV hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002883 ! regulation of hypersensitivity +relationship: regulates GO:0001806 ! type IV hypersensitivity + +[Term] +id: GO:0001808 +name: negative regulation of type IV hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of type IV hypersensitivity" EXACT [] +synonym: "down-regulation of type IV hypersensitivity" EXACT [] +synonym: "downregulation of type IV hypersensitivity" EXACT [] +synonym: "inhibition of type IV hypersensitivity" NARROW [] +is_a: GO:0001807 ! regulation of type IV hypersensitivity +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002884 ! negative regulation of hypersensitivity +relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity + +[Term] +id: GO:0001809 +name: positive regulation of type IV hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of type IV hypersensitivity" NARROW [] +synonym: "stimulation of type IV hypersensitivity" NARROW [] +synonym: "up regulation of type IV hypersensitivity" EXACT [] +synonym: "up-regulation of type IV hypersensitivity" EXACT [] +synonym: "upregulation of type IV hypersensitivity" EXACT [] +is_a: GO:0001807 ! regulation of type IV hypersensitivity +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002885 ! positive regulation of hypersensitivity +relationship: positively_regulates GO:0001806 ! type IV hypersensitivity + +[Term] +id: GO:0001810 +name: regulation of type I hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002883 ! regulation of hypersensitivity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0001811 +name: negative regulation of type I hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of type I hypersensitivity" EXACT [] +synonym: "down-regulation of type I hypersensitivity" EXACT [] +synonym: "downregulation of type I hypersensitivity" EXACT [] +synonym: "inhibition of type I hypersensitivity" NARROW [] +is_a: GO:0001810 ! regulation of type I hypersensitivity +is_a: GO:0002884 ! negative regulation of hypersensitivity +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +relationship: negatively_regulates GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0001812 +name: positive regulation of type I hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of type I hypersensitivity" NARROW [] +synonym: "stimulation of type I hypersensitivity" NARROW [] +synonym: "up regulation of type I hypersensitivity" EXACT [] +synonym: "up-regulation of type I hypersensitivity" EXACT [] +synonym: "upregulation of type I hypersensitivity" EXACT [] +is_a: GO:0001810 ! regulation of type I hypersensitivity +is_a: GO:0002885 ! positive regulation of hypersensitivity +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +relationship: positively_regulates GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0001813 +name: regulation of antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of antibody dependent cell death" EXACT [] +synonym: "regulation of antibody dependent cell killing" EXACT [] +synonym: "regulation of antibody-dependent cell death" EXACT [] +synonym: "regulation of antibody-dependent cell killing" EXACT [] +is_a: GO:0001796 ! regulation of type IIa hypersensitivity +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity + +[Term] +id: GO:0001814 +name: negative regulation of antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] +synonym: "negative regulation of antibody dependent cell death" EXACT [] +synonym: "negative regulation of antibody dependent cell killing" EXACT [] +synonym: "negative regulation of antibody-dependent cell death" EXACT [] +synonym: "negative regulation of antibody-dependent cell killing" EXACT [] +is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity +is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity + +[Term] +id: GO:0001815 +name: positive regulation of antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] +synonym: "positive regulation of antibody dependent cell death" EXACT [] +synonym: "positive regulation of antibody dependent cell killing" EXACT [] +synonym: "positive regulation of antibody-dependent cell death" EXACT [] +synonym: "positive regulation of antibody-dependent cell killing" EXACT [] +synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] +synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] +is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity +is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity + +[Term] +id: GO:0001816 +name: cytokine production +namespace: biological_process +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0001817 +name: regulation of cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0001818 +name: negative regulation of cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of cytokine production" EXACT [] +synonym: "down-regulation of cytokine production" EXACT [] +synonym: "downregulation of cytokine production" EXACT [] +synonym: "inhibition of cytokine production" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0001819 +name: positive regulation of cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of cytokine production" NARROW [] +synonym: "stimulation of cytokine production" NARROW [] +synonym: "up regulation of cytokine production" EXACT [] +synonym: "up-regulation of cytokine production" EXACT [] +synonym: "upregulation of cytokine production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0001820 +name: serotonin secretion +namespace: biological_process +def: "The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"] +synonym: "5-HT secretion" EXACT [] +synonym: "5-hydroxytryptamine secretion" EXACT [] +is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling +is_a: GO:0006837 ! serotonin transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0001821 +name: histamine secretion +namespace: biological_process +def: "The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0051608 ! histamine transport + +[Term] +id: GO:0001822 +name: kidney development +namespace: biological_process +def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0001655 ! urogenital system development + +[Term] +id: GO:0001823 +name: mesonephros development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is a transient excretory organ of the embryo." [GOC:dph, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0001822 ! kidney development + +[Term] +id: GO:0001824 +name: blastocyst development +namespace: biological_process +def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001701 ! in utero embryonic development + +[Term] +id: GO:0001825 +name: blastocyst formation +namespace: biological_process +def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0001824 ! blastocyst development + +[Term] +id: GO:0001826 +name: inner cell mass cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001825 ! blastocyst formation + +[Term] +id: GO:0001827 +name: inner cell mass cell fate commitment +namespace: biological_process +def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001826 ! inner cell mass cell differentiation + +[Term] +id: GO:0001828 +name: inner cell mass cellular morphogenesis +namespace: biological_process +def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0001826 ! inner cell mass cell differentiation + +[Term] +id: GO:0001829 +name: trophectodermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. +synonym: "trophectoderm cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001825 ! blastocyst formation + +[Term] +id: GO:0001830 +name: trophectodermal cell fate commitment +namespace: biological_process +def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. +synonym: "trophectoderm cell fate commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001829 ! trophectodermal cell differentiation + +[Term] +id: GO:0001831 +name: trophectodermal cellular morphogenesis +namespace: biological_process +def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. +synonym: "trophectoderm cellular morphogenesis" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0001829 ! trophectodermal cell differentiation + +[Term] +id: GO:0001832 +name: blastocyst growth +namespace: biological_process +def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0001824 ! blastocyst development + +[Term] +id: GO:0001833 +name: inner cell mass cell proliferation +namespace: biological_process +def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0001832 ! blastocyst growth + +[Term] +id: GO:0001834 +name: trophectodermal cell proliferation +namespace: biological_process +def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. +synonym: "trophectoderm cell proliferation" EXACT [] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0001832 ! blastocyst growth + +[Term] +id: GO:0001835 +name: blastocyst hatching +namespace: biological_process +def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. +is_a: GO:0035188 ! hatching +relationship: part_of GO:0001824 ! blastocyst development + +[Term] +id: GO:0001836 +name: release of cytochrome c from mitochondria +namespace: biological_process +def: "The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:add, GOC:mah, ISBN:0721639976, PMID:12925707, PMID:9560217] +is_a: GO:0008637 ! apoptotic mitochondrial changes + +[Term] +id: GO:0001837 +name: epithelial to mesenchymal transition +namespace: biological_process +def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] +synonym: "EMT" EXACT [] +synonym: "epithelial-mesenchymal transition" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0060232 ! delamination +relationship: part_of GO:0014031 ! mesenchymal cell development + +[Term] +id: GO:0001838 +name: embryonic epithelial tube formation +namespace: biological_process +def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0035239 ! tube morphogenesis + +[Term] +id: GO:0001839 +name: neural plate morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001840 ! neural plate development + +[Term] +id: GO:0001840 +name: neural plate development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium + +[Term] +id: GO:0001841 +name: neural tube formation +namespace: biological_process +alt_id: GO:0001679 +def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] +synonym: "neural tube morphogenesis" EXACT [GOC:dph] +synonym: "neurulation" EXACT [] +is_a: GO:0001838 ! embryonic epithelial tube formation +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0001842 +name: neural fold formation +namespace: biological_process +def: "The process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001839 ! neural plate morphogenesis +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0001843 +name: neural tube closure +namespace: biological_process +def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0001844 +name: protein insertion into mitochondrial membrane during induction of apoptosis +namespace: biological_process +def: "The process by which a protein is incorporated into a mitochondrial membrane as an early step in apoptosis." [GOC:add, PMID:12952892] +comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. +synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" EXACT [] +synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" EXACT [] +xref: Reactome:114264 +xref: Reactome:139905 +xref: Reactome:139909 +xref: Reactome:139914 +xref: Reactome:139919 +xref: Reactome:140216 +xref: Reactome:211289 +xref: Reactome:211290 +xref: Reactome:211292 +xref: Reactome:211294 +xref: Reactome:211310 +xref: Reactome:211313 +xref: Reactome:221100 +xref: Reactome:221101 +xref: Reactome:221103 +xref: Reactome:221105 +xref: Reactome:221120 +xref: Reactome:229760 +xref: Reactome:229762 +xref: Reactome:237763 +xref: Reactome:237765 +is_a: GO:0008637 ! apoptotic mitochondrial changes +is_a: GO:0051204 ! protein insertion into mitochondrial membrane +relationship: part_of GO:0006917 ! induction of apoptosis + +[Term] +id: GO:0001845 +name: phagolysosome formation +namespace: biological_process +def: "The process by which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "late phagosome biosynthesis" RELATED [] +synonym: "late phagosome formation" RELATED [] +is_a: GO:0006909 ! phagocytosis + +[Term] +id: GO:0001846 +name: opsonin binding +namespace: molecular_function +def: "Interacting selectively with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001847 +name: opsonin receptor activity +namespace: molecular_function +def: "Combining with an opsonin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0001848 +name: complement binding +namespace: molecular_function +def: "Interacting selectively with any component or product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001849 +name: complement component C1q binding +namespace: molecular_function +def: "Interacting selectively with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001850 +name: complement component C3a binding +namespace: molecular_function +def: "Interacting selectively with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001851 +name: complement component C3b binding +namespace: molecular_function +def: "Interacting selectively with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001852 +name: complement component iC3b binding +namespace: molecular_function +def: "Interacting selectively with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001853 +name: complement component C3dg binding +namespace: molecular_function +def: "Interacting selectively with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001854 +name: complement component C3d binding +namespace: molecular_function +def: "Interacting selectively with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001855 +name: complement component C4b binding +namespace: molecular_function +def: "Interacting selectively with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001856 +name: complement component C5a binding +namespace: molecular_function +def: "Interacting selectively with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001857 +name: complement component C1q receptor activity +namespace: molecular_function +def: "Combining with the C1q component of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0001849 ! complement component C1q binding +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001858 +name: complement component iC3b receptor activity +namespace: molecular_function +def: "Combining with the iC3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0001852 ! complement component iC3b binding +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001859 +name: complement component C3dg receptor activity +namespace: molecular_function +def: "Combining with the C3dg product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001860 +name: complement component C3d receptor activity +namespace: molecular_function +def: "Combining with the C3d product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001861 +name: complement component C4b receptor activity +namespace: molecular_function +def: "Combining with the C4b product of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0001855 ! complement component C4b binding +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001862 +name: collectin binding +namespace: molecular_function +def: "Interacting selectively with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). +is_a: GO:0001846 ! opsonin binding + +[Term] +id: GO:0001863 +name: collectin receptor activity +namespace: molecular_function +def: "Combining with a collectin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). +is_a: GO:0001847 ! opsonin receptor activity + +[Term] +id: GO:0001864 +name: pentraxin binding +namespace: molecular_function +def: "Interacting selectively with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). +is_a: GO:0001846 ! opsonin binding + +[Term] +id: GO:0001865 +name: NK T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459] +comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. +synonym: "natural killer T cell differentiation" EXACT [] +synonym: "natural T cell differentiation" EXACT [] +synonym: "NK T lymphocyte differentiation" EXACT [] +synonym: "NK T-cell differentiation" EXACT [] +synonym: "NK T-lymphocyte differentiation" EXACT [] +synonym: "NKT cell differentiation" EXACT [] +synonym: "NT cell differentiation" EXACT [] +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0001866 +name: NK T cell proliferation +namespace: biological_process +def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459] +comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. +synonym: "natural killer T cell proliferation" EXACT [] +synonym: "natural T cell proliferation" EXACT [] +synonym: "NK T lymphocyte proliferation" EXACT [] +synonym: "NK T-cell proliferation" EXACT [] +synonym: "NK T-lymphocyte proliferation" EXACT [] +synonym: "NKT cell proliferation" EXACT [] +synonym: "NT cell proliferation" EXACT [] +is_a: GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0001867 +name: complement activation, lectin pathway +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. +xref: Reactome:166662 +xref: Reactome:211612 +xref: Reactome:221386 +xref: Reactome:230022 +is_a: GO:0006956 ! complement activation +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0001868 +name: regulation of complement activation, lectin pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0001867 ! complement activation, lectin pathway + +[Term] +id: GO:0001869 +name: negative regulation of complement activation, lectin pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of complement activation, lectin pathway" EXACT [] +synonym: "down-regulation of complement activation, lectin pathway" EXACT [] +synonym: "downregulation of complement activation, lectin pathway" EXACT [] +synonym: "inhibition of complement activation, lectin pathway" NARROW [] +is_a: GO:0001868 ! regulation of complement activation, lectin pathway +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway + +[Term] +id: GO:0001870 +name: positive regulation of complement activation, lectin pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of complement activation, lectin pathway" NARROW [] +synonym: "stimulation of complement activation, lectin pathway" NARROW [] +synonym: "up regulation of complement activation, lectin pathway" EXACT [] +synonym: "up-regulation of complement activation, lectin pathway" EXACT [] +synonym: "upregulation of complement activation, lectin pathway" EXACT [] +is_a: GO:0001868 ! regulation of complement activation, lectin pathway +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway + +[Term] +id: GO:0001871 +name: pattern binding +namespace: molecular_function +def: "Interacting selectively with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] +comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead. +subset: goslim_pir +subset: gosubset_prok +synonym: "pattern recognition activity" BROAD [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0001872 +name: zymosan binding +namespace: molecular_function +def: "Interacting selectively with zymosan." [PMID:14707091] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0001873 +name: polysaccharide receptor activity +namespace: molecular_function +def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091] +is_a: GO:0008329 ! pattern recognition receptor activity +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0001874 +name: zymosan receptor activity +namespace: molecular_function +def: "Combining with zymosan to initiate a change in cell activity." [PMID:14707091] +is_a: GO:0001872 ! zymosan binding +is_a: GO:0001873 ! polysaccharide receptor activity + +[Term] +id: GO:0001875 +name: lipopolysaccharide receptor activity +namespace: molecular_function +def: "Combining with lipopolysaccharide to initiate a change in cell activity." [PMID:14609719] +synonym: "endotoxin receptor activity" BROAD [] +synonym: "LPS receptor activity" EXACT [] +is_a: GO:0001530 ! lipopolysaccharide binding +is_a: GO:0008329 ! pattern recognition receptor activity + +[Term] +id: GO:0001876 +name: lipoarabinomannan binding +namespace: molecular_function +def: "Interacting selectively with lipoarabinomannan." [PMID:10586073] +synonym: "LAM binding" EXACT [] +is_a: GO:0001871 ! pattern binding + +[Term] +id: GO:0001877 +name: lipoarabinomannan receptor activity +namespace: molecular_function +def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073] +synonym: "LAM receptor activity" EXACT [] +is_a: GO:0001876 ! lipoarabinomannan binding +is_a: GO:0008329 ! pattern recognition receptor activity + +[Term] +id: GO:0001878 +name: response to yeast +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] +is_a: GO:0009620 ! response to fungus + +[Term] +id: GO:0001879 +name: detection of yeast +namespace: biological_process +def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] +is_a: GO:0001878 ! response to yeast +is_a: GO:0016046 ! detection of fungus + +[Term] +id: GO:0001880 +name: Mullerian duct regression +namespace: biological_process +def: "The process by which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0001881 +name: receptor recycling +namespace: biological_process +def: "The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] +is_a: GO:0043112 ! receptor metabolic process +relationship: part_of GO:0007165 ! signal transduction + +[Term] +id: GO:0001882 +name: nucleoside binding +namespace: molecular_function +def: "Interacting selectively with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0001883 +name: purine nucleoside binding +namespace: molecular_function +def: "Interacting selectively with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0001884 +name: pyrimidine nucleoside binding +namespace: molecular_function +def: "Interacting selectively with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0001885 +name: endothelial cell development +namespace: biological_process +def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0001886 +name: endothelial cell morphogenesis +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:dph] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0001885 ! endothelial cell development + +[Term] +id: GO:0001887 +name: selenium metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nonmetallic element selenium or compounds that contain selenium, such as selenocysteine." [PMID:12730456] +subset: gosubset_prok +synonym: "selenium metabolism" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0001888 +name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] +synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] +synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] +synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] +synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] +xref: EC:2.4.1.223 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0001889 +name: liver development +namespace: biological_process +def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] +is_a: GO:0009887 ! organ morphogenesis +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0001890 +name: placenta development +namespace: biological_process +def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] +synonym: "placental development" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0001891 +name: phagocytic cup +namespace: cellular_component +def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0001892 +name: embryonic placenta development +namespace: biological_process +def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] +is_a: GO:0001890 ! placenta development +relationship: part_of GO:0001701 ! in utero embryonic development + +[Term] +id: GO:0001893 +name: maternal placenta development +namespace: biological_process +def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] +is_a: GO:0001890 ! placenta development + +[Term] +id: GO:0001894 +name: tissue homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] +synonym: "tissue maintenance" NARROW [GOC:add] +is_a: GO:0060249 ! anatomical structure homeostasis +relationship: part_of GO:0048871 ! multicellular organismal homeostasis + +[Term] +id: GO:0001895 +name: retina homeostasis +namespace: biological_process +def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0001896 +name: autolysis +namespace: biological_process +def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add] +subset: gosubset_prok +is_a: GO:0019835 ! cytolysis + +[Term] +id: GO:0001897 +name: cytolysis by symbiont of host cells +namespace: biological_process +def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +synonym: "cytolysis by organism of host cells" EXACT [] +is_a: GO:0001907 ! killing by symbiont of host cells +is_a: GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction +is_a: GO:0052025 ! modification by symbiont of host cell membrane + +[Term] +id: GO:0001898 +name: regulation of cytolysis by symbiont of host cells +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction +relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0001899 +name: negative regulation of cytolysis by symbiont of host cells +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] +synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells +is_a: GO:0051803 ! negative regulation of cytolysis of cells in other organism during symbiotic interaction +relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0001900 +name: positive regulation of cytolysis by symbiont of host cells +namespace: biological_process +def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "activation by symbiont of cytolysis of host cells" NARROW [] +synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] +synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] +is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells +is_a: GO:0051804 ! positive regulation of cytolysis of cells in other organism during symbiotic interaction +relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0001905 +name: activation of membrane attack complex +namespace: biological_process +def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of MAC" EXACT [] +synonym: "activation of TCC" NARROW [] +synonym: "activation of the terminal complement cascade" NARROW [] +is_a: GO:0006956 ! complement activation + +[Term] +id: GO:0001906 +name: cell killing +namespace: biological_process +def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] +subset: goslim_pir +subset: gosubset_prok +synonym: "necrosis" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0001907 +name: killing by symbiont of host cells +namespace: biological_process +def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0044004 ! disruption by symbiont of host cells +is_a: GO:0051883 ! killing of cells in other organism during symbiotic interaction + +[Term] +id: GO:0001909 +name: leukocyte mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a leukocyte." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] +comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. +synonym: "immune cell mediated cell death" EXACT [] +synonym: "immune cell mediated cell killing" EXACT [] +synonym: "immune cell mediated cytotoxicity" EXACT [] +synonym: "leucocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001906 ! cell killing +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0001910 +name: regulation of leukocyte mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] +synonym: "regulation of immune cell mediated cell death" EXACT [] +synonym: "regulation of immune cell mediated cell killing" EXACT [] +synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] +synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0031341 ! regulation of cell killing +relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001911 +name: negative regulation of leukocyte mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] +synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] +synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] +synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0031342 ! negative regulation of cell killing +relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001912 +name: positive regulation of leukocyte mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] +synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] +synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] +synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] +synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] +synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0031343 ! positive regulation of cell killing +relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001913 +name: T cell mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. +synonym: "T cell mediated apoptosis" EXACT [] +synonym: "T cell mediated cell death" EXACT [] +synonym: "T cell mediated cell killing" EXACT [] +synonym: "T cell mediated cytolysis" RELATED [] +synonym: "T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "T-cell mediated apoptosis" EXACT [] +synonym: "T-cell mediated cell death" EXACT [] +synonym: "T-cell mediated cell killing" EXACT [] +synonym: "T-cell mediated cytotoxicity" EXACT [] +synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0002456 ! T cell mediated immunity +is_a: GO:0006917 ! induction of apoptosis + +[Term] +id: GO:0001914 +name: regulation of T cell mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of T cell mediated apoptosis" EXACT [] +synonym: "regulation of T cell mediated cell death" EXACT [] +synonym: "regulation of T cell mediated cell killing" EXACT [] +synonym: "regulation of T cell mediated cytolysis" RELATED [] +synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "regulation of T-cell mediated apoptosis" EXACT [] +synonym: "regulation of T-cell mediated cell death" EXACT [] +synonym: "regulation of T-cell mediated cell killing" EXACT [] +synonym: "regulation of T-cell mediated cytolysis" RELATED [] +synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] +synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002709 ! regulation of T cell mediated immunity +relationship: regulates GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0001915 +name: negative regulation of T cell mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] +synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] +synonym: "negative regulation of T cell mediated apoptosis" EXACT [] +synonym: "negative regulation of T cell mediated cell death" EXACT [] +synonym: "negative regulation of T cell mediated cell killing" EXACT [] +synonym: "negative regulation of T cell mediated cytolysis" RELATED [] +synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] +synonym: "negative regulation of T-cell mediated cell death" EXACT [] +synonym: "negative regulation of T-cell mediated cell killing" EXACT [] +synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] +synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] +synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0001916 +name: positive regulation of T cell mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of T cell mediated cytotoxicity" NARROW [] +synonym: "positive regulation of T cell mediated apoptosis" EXACT [] +synonym: "positive regulation of T cell mediated cell death" EXACT [] +synonym: "positive regulation of T cell mediated cell killing" EXACT [] +synonym: "positive regulation of T cell mediated cytolysis" RELATED [] +synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] +synonym: "positive regulation of T-cell mediated cell death" EXACT [] +synonym: "positive regulation of T-cell mediated cell killing" EXACT [] +synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] +synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] +synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] +synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] +synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0001917 +name: photoreceptor inner segment +namespace: cellular_component +def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] +subset: goslim_pir +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0001918 +name: farnesylated protein binding +namespace: molecular_function +def: "Interacting selectively with a farnesylated protein." [GOC:add, PMID:14555765] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001919 +name: regulation of receptor recycling +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of receptor recyling." [GOC:add] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0001881 ! receptor recycling + +[Term] +id: GO:0001920 +name: negative regulation of receptor recycling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of receptor recyling." [GOC:add] +synonym: "down regulation of receptor recycling" EXACT [] +synonym: "down-regulation of receptor recycling" EXACT [] +synonym: "downregulation of receptor recycling" EXACT [] +synonym: "inhibition of receptor recycling" NARROW [] +is_a: GO:0001919 ! regulation of receptor recycling +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +relationship: negatively_regulates GO:0001881 ! receptor recycling + +[Term] +id: GO:0001921 +name: positive regulation of receptor recycling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor recyling." [GOC:add] +synonym: "activation of receptor recycling" NARROW [] +synonym: "stimulation of receptor recycling" NARROW [] +synonym: "up regulation of receptor recycling" EXACT [] +synonym: "up-regulation of receptor recycling" EXACT [] +synonym: "upregulation of receptor recycling" EXACT [] +is_a: GO:0001919 ! regulation of receptor recycling +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +relationship: positively_regulates GO:0001881 ! receptor recycling + +[Term] +id: GO:0001922 +name: B-1 B cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. +synonym: "B-1 B lymphocyte homeostasis" EXACT [] +synonym: "B-1 B-cell homeostasis" EXACT [] +synonym: "B-1 B-lymphocyte homeostasis" EXACT [] +is_a: GO:0001782 ! B cell homeostasis + +[Term] +id: GO:0001923 +name: B-1 B cell differentiation +namespace: biological_process +def: "The process whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B-1 B lymphocyte differentiation" EXACT [] +synonym: "B-1 B-cell differentiation" EXACT [] +synonym: "B-1 B-lymphocyte differentiation" EXACT [] +is_a: GO:0002335 ! mature B cell differentiation + +[Term] +id: GO:0001924 +name: regulation of B-1 B cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] +synonym: "regulation of B-1 B-cell differentiation" EXACT [] +synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] +is_a: GO:0045577 ! regulation of B cell differentiation +relationship: regulates GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0001925 +name: negative regulation of B-1 B cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of B-1 B cell differentiation" EXACT [] +synonym: "down-regulation of B-1 B cell differentiation" EXACT [] +synonym: "downregulation of B-1 B cell differentiation" EXACT [] +synonym: "inhibition of B-1 B cell differentiation" NARROW [] +synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] +synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] +synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] +is_a: GO:0001924 ! regulation of B-1 B cell differentiation +is_a: GO:0045578 ! negative regulation of B cell differentiation +relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0001926 +name: positive regulation of B-1 B cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of B-1 B cell differentiation" NARROW [] +synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] +synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] +synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] +synonym: "stimulation of B-1 B cell differentiation" NARROW [] +synonym: "up regulation of B-1 B cell differentiation" EXACT [] +synonym: "up-regulation of B-1 B cell differentiation" EXACT [] +synonym: "upregulation of B-1 B cell differentiation" EXACT [] +is_a: GO:0001924 ! regulation of B-1 B cell differentiation +is_a: GO:0045579 ! positive regulation of B cell differentiation +relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0001927 +name: exocyst assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, http://en.wikipedia.org/wiki/Exocyst] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0006904 ! vesicle docking during exocytosis + +[Term] +id: GO:0001928 +name: regulation of exocyst assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] +comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0043254 ! regulation of protein complex assembly +relationship: regulates GO:0001927 ! exocyst assembly + +[Term] +id: GO:0001929 +name: negative regulation of exocyst assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of exocyst assembly." [GOC:hjd] +synonym: "down regulation of exocyst assembly" EXACT [] +synonym: "down-regulation of exocyst assembly" EXACT [] +synonym: "downregulation of exocyst assembly" EXACT [] +synonym: "inhibition of exocyst assembly" NARROW [] +is_a: GO:0001928 ! regulation of exocyst assembly +is_a: GO:0031333 ! negative regulation of protein complex assembly +relationship: negatively_regulates GO:0001927 ! exocyst assembly + +[Term] +id: GO:0001930 +name: positive regulation of exocyst assembly +namespace: biological_process +def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] +synonym: "activation of exocyst assembly" NARROW [] +synonym: "stimulation of exocyst assembly" NARROW [] +synonym: "up regulation of exocyst assembly" EXACT [] +synonym: "up-regulation of exocyst assembly" EXACT [] +synonym: "upregulation of exocyst assembly" EXACT [] +is_a: GO:0001928 ! regulation of exocyst assembly +is_a: GO:0031334 ! positive regulation of protein complex assembly +relationship: positively_regulates GO:0001927 ! exocyst assembly + +[Term] +id: GO:0001931 +name: uropod +namespace: cellular_component +def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750] +synonym: "distal pole complex" RELATED [] +synonym: "retractile pole" RELATED [] +synonym: "uropodium" EXACT [] +is_a: GO:0042995 ! cell projection +relationship: part_of GO:0031254 ! trailing edge + +[Term] +id: GO:0001932 +name: regulation of protein amino acid phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] +subset: gosubset_prok +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0042325 ! regulation of phosphorylation +relationship: regulates GO:0006468 ! protein amino acid phosphorylation + +[Term] +id: GO:0001933 +name: negative regulation of protein amino acid phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] +subset: gosubset_prok +synonym: "down regulation of protein amino acid phosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] +synonym: "downregulation of protein amino acid phosphorylation" EXACT [] +synonym: "inhibition of protein amino acid phosphorylation" NARROW [] +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0042326 ! negative regulation of phosphorylation +relationship: negatively_regulates GO:0006468 ! protein amino acid phosphorylation + +[Term] +id: GO:0001934 +name: positive regulation of protein amino acid phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] +subset: gosubset_prok +synonym: "activation of protein amino acid phosphorylation" NARROW [] +synonym: "stimulation of protein amino acid phosphorylation" NARROW [] +synonym: "up regulation of protein amino acid phosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] +synonym: "upregulation of protein amino acid phosphorylation" EXACT [] +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0042327 ! positive regulation of phosphorylation +relationship: positively_regulates GO:0006468 ! protein amino acid phosphorylation + +[Term] +id: GO:0001935 +name: endothelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0001936 +name: regulation of endothelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0001937 +name: negative regulation of endothelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] +synonym: "down regulation of endothelial cell proliferation" EXACT [] +synonym: "down-regulation of endothelial cell proliferation" EXACT [] +synonym: "downregulation of endothelial cell proliferation" EXACT [] +synonym: "inhibition of endothelial cell proliferation" NARROW [] +is_a: GO:0001936 ! regulation of endothelial cell proliferation +is_a: GO:0008285 ! negative regulation of cell proliferation +relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0001938 +name: positive regulation of endothelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] +synonym: "activation of endothelial cell proliferation" NARROW [] +synonym: "stimulation of endothelial cell proliferation" NARROW [] +synonym: "up regulation of endothelial cell proliferation" EXACT [] +synonym: "up-regulation of endothelial cell proliferation" EXACT [] +synonym: "upregulation of endothelial cell proliferation" EXACT [] +is_a: GO:0001936 ! regulation of endothelial cell proliferation +is_a: GO:0008284 ! positive regulation of cell proliferation +relationship: positively_regulates GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0001939 +name: female pronucleus +namespace: cellular_component +def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0045120 ! pronucleus + +[Term] +id: GO:0001940 +name: male pronucleus +namespace: cellular_component +def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0045120 ! pronucleus + +[Term] +id: GO:0001941 +name: postsynaptic membrane organization +namespace: biological_process +def: "The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph] +synonym: "postsynaptic membrane organisation" EXACT [] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0001942 +name: hair follicle development +namespace: biological_process +alt_id: GO:0001943 +def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, http://cancerweb.ncl.ac.uk] +is_a: GO:0008544 ! epidermis development +is_a: GO:0022405 ! hair cycle process + +[Term] +id: GO:0001944 +name: vasculature development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0001945 +name: lymph vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lymphatic vasculature over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0001944 ! vasculature development + +[Term] +id: GO:0001946 +name: lymphangiogenesis +namespace: biological_process +def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] +synonym: "lymph vessel formation" EXACT systematic_synonym [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001945 ! lymph vessel development + +[Term] +id: GO:0001947 +name: heart looping +namespace: biological_process +def: "The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceeding their future integration." [GOC:dph, PMID:12094232] +synonym: "cardiac jogging" EXACT [] +synonym: "cardiac looping" RELATED [] +is_a: GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0001948 +name: glycoprotein binding +namespace: molecular_function +def: "Interacting selectively with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001949 +name: sebaceous gland cell differentiation +namespace: biological_process +def: "Process whereby a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] +synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] +is_a: GO:0009913 ! epidermal cell differentiation +relationship: part_of GO:0048733 ! sebaceous gland development + +[Term] +id: GO:0001950 +name: PME fraction +namespace: cellular_component +def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] +is_a: GO:0000267 ! cell fraction +relationship: part_of GO:0005624 ! membrane fraction + +[Term] +id: GO:0001951 +name: D-glucose absorption +namespace: biological_process +def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] +is_a: GO:0050892 ! intestinal absorption + +[Term] +id: GO:0001952 +name: regulation of cell-matrix adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] +is_a: GO:0010810 ! regulation of cell-substrate adhesion +relationship: regulates GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0001953 +name: negative regulation of cell-matrix adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] +synonym: "down regulation of cell-matrix adhesion" EXACT [] +synonym: "down-regulation of cell-matrix adhesion" EXACT [] +synonym: "downregulation of cell-matrix adhesion" EXACT [] +synonym: "inhibition of cell-matrix adhesion" NARROW [] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0010812 ! negative regulation of cell-substrate adhesion +relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0001954 +name: positive regulation of cell-matrix adhesion +namespace: biological_process +def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] +synonym: "activation of cell-matrix adhesion" NARROW [] +synonym: "stimulation of cell-matrix adhesion" NARROW [] +synonym: "up regulation of cell-matrix adhesion" EXACT [] +synonym: "up-regulation of cell-matrix adhesion" EXACT [] +synonym: "upregulation of cell-matrix adhesion" EXACT [] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +is_a: GO:0010811 ! positive regulation of cell-substrate adhesion +relationship: positively_regulates GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0001955 +name: blood vessel maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0001568 ! blood vessel development + +[Term] +id: GO:0001956 +name: positive regulation of neurotransmitter secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] +synonym: "activation of neurotransmitter secretion" NARROW [] +synonym: "stimulation of neurotransmitter secretion" NARROW [] +synonym: "up regulation of neurotransmitter secretion" EXACT [] +synonym: "up-regulation of neurotransmitter secretion" EXACT [] +synonym: "upregulation of neurotransmitter secretion" EXACT [] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051590 ! positive regulation of neurotransmitter transport +relationship: positively_regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0001957 +name: intramembranous ossification +namespace: biological_process +def: "The formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified. Intramembranous ossification is the way flat bones and the shell of a turtle are formed." [ISBN:0878932437] +is_a: GO:0001503 ! ossification + +[Term] +id: GO:0001958 +name: endochondral ossification +namespace: biological_process +def: "The formation of bone by the replacement of cartilage tissue with mineralized bone." [ISBN:0878932437] +is_a: GO:0001503 ! ossification +relationship: part_of GO:0060350 ! endochondral bone morphogenesis + +[Term] +id: GO:0001959 +name: regulation of cytokine mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] +synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "regulation of cytokine mediated signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0001960 +name: negative regulation of cytokine mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] +synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] +synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] +synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0001961 +name: positive regulation of cytokine mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] +synonym: "activation of cytokine mediated signaling pathway" NARROW [] +synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] +synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] +synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0001962 +name: alpha-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:hjd, PMID:10854427] +synonym: "isoglobotriaosylceramide synthase" NARROW [] +xref: EC:2.4.1.- +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0001963 +name: synaptic transmission, dopaminergic +namespace: biological_process +def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph] +is_a: GO:0007270 ! nerve-nerve synaptic transmission + +[Term] +id: GO:0001964 +name: startle response +namespace: biological_process +def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0001965 +name: G-protein alpha-subunit binding +namespace: molecular_function +def: "Interacting selectively with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] +synonym: "G-alpha protein subunit binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001966 +name: thigmotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] +synonym: "stereotaxis" EXACT [] +synonym: "taxis in response to mechanical stimulus" BROAD [] +synonym: "taxis in response to touch stimulus" EXACT [] +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0001967 +name: suckling behavior +namespace: biological_process +def: "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph] +synonym: "nursing behavior" EXACT [] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0051705 ! behavioral interaction between organisms + +[Term] +id: GO:0001968 +name: fibronectin binding +namespace: molecular_function +def: "Interacting selectively with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001969 +name: regulation of activation of membrane attack complex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0042268 ! regulation of cytolysis +relationship: regulates GO:0001905 ! activation of membrane attack complex + +[Term] +id: GO:0001970 +name: positive regulation of activation of membrane attack complex +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] +synonym: "activation of activation of membrane attack complex" NARROW [] +synonym: "stimulation of activation of membrane attack complex" NARROW [] +synonym: "up regulation of activation of membrane attack complex" EXACT [] +synonym: "up-regulation of activation of membrane attack complex" EXACT [] +synonym: "upregulation of activation of membrane attack complex" EXACT [] +is_a: GO:0001969 ! regulation of activation of membrane attack complex +is_a: GO:0045917 ! positive regulation of complement activation +is_a: GO:0045919 ! positive regulation of cytolysis +relationship: positively_regulates GO:0001905 ! activation of membrane attack complex + +[Term] +id: GO:0001971 +name: negative regulation of activation of membrane attack complex +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] +synonym: "down regulation of activation of membrane attack complex" EXACT [] +synonym: "down-regulation of activation of membrane attack complex" EXACT [] +synonym: "downregulation of activation of membrane attack complex" EXACT [] +synonym: "inhibition of activation of membrane attack complex" NARROW [] +is_a: GO:0001969 ! regulation of activation of membrane attack complex +is_a: GO:0045916 ! negative regulation of complement activation +is_a: GO:0045918 ! negative regulation of cytolysis +relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex + +[Term] +id: GO:0001972 +name: retinoic acid binding +namespace: molecular_function +def: "Interacting selectively with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] +is_a: GO:0005501 ! retinoid binding + +[Term] +id: GO:0001973 +name: adenosine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "adenosine receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0001974 +name: blood vessel remodeling +namespace: biological_process +def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0001975 +name: response to amphetamine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef] +is_a: GO:0014075 ! response to amine stimulus + +[Term] +id: GO:0001976 +name: regulation of systemic arterial blood pressure by neurological process +namespace: biological_process +def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "blood pressure regulation by neurological process" EXACT [] +synonym: "fast control of arterial pressure" RELATED [] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure +is_a: GO:0050877 ! neurological system process + +[Term] +id: GO:0001977 +name: regulation of blood volume by renal system process +namespace: biological_process +def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "renal blood volume control of blood pressure" RELATED [] +synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] +is_a: GO:0003071 ! regulation of systemic arterial blood pressure by renal system process +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0001978 +name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback +namespace: biological_process +def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "baroreceptor feedback control of blood pressure" RELATED [] +synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X "Stedman's Medical Dictionary"] +synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process +relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback + +[Term] +id: GO:0001979 +name: regulation of systemic arterial blood pressure by chemoreceptor +namespace: biological_process +def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "chemoreceptor control of blood pressure" RELATED [] +synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process + +[Term] +id: GO:0001980 +name: regulation of systemic arterial blood pressure by ischemic conditions +namespace: biological_process +def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "CNS ischemic response" RELATED [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "ischemic control of blood pressure" RELATED [] +synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process + +[Term] +id: GO:0001981 +name: baroreceptor detection of arterial stretch +namespace: biological_process +def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0050982 ! detection of mechanical stimulus +relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback + +[Term] +id: GO:0001982 +name: baroreceptor response to decreased systemic arterial blood pressure +namespace: biological_process +def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0001983 +name: baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback +relationship: part_of GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0001984 +name: vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0001985 +name: negative regulation of heart rate in baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] +synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] +synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +is_a: GO:0010459 ! negative regulation of heart rate +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0001986 +name: negative regulation of the force of heart contraction during baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] +synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] +is_a: GO:0045822 ! negative regulation of heart contraction +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0001987 +name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0001988 +name: positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] +synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] +synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] +synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0001989 +name: positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" EXACT [] +synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] +is_a: GO:0045823 ! positive regulation of heart contraction +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0001990 +name: regulation of systemic arterial blood pressure by hormone +namespace: biological_process +def: "The process by which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "blood pressure regulation by hormone" EXACT [] +synonym: "hormonal control of blood pressure" RELATED [] +synonym: "hormonal regulation of blood pressure" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal +is_a: GO:0050886 ! endocrine process + +[Term] +id: GO:0001991 +name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin +namespace: biological_process +def: "The process by which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] +synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] +synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] +synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] +synonym: "renin-angiotensin blood pressure control" RELATED [] +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin + +[Term] +id: GO:0001992 +name: regulation of systemic arterial blood pressure by vasopressin +namespace: biological_process +def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "blood pressure regulation by vasopressin" EXACT [] +synonym: "vasopressin control of blood pressure" RELATED [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0001993 +name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine +namespace: biological_process +def: "The process by which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] +synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] +synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal + +[Term] +id: GO:0001994 +name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] +synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] +synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] +synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0001995 +name: norepinephrine-epinephrine catabolic process in blood stream +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] +synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] +is_a: GO:0042419 ! epinephrine catabolic process +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0001996 +name: positive regulation of heart rate by epinephrine-norepinephrine +namespace: biological_process +def: "The process by which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] +synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] +synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] +synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] +synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] +synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] +synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] +synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] +synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] +synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] +synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0001997 +name: positive regulation of the force of heart contraction by epinephrine-norepinephrine +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] +synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] +synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] +synonym: "increased inotropy by epinephrine-norepinephrine " RELATED [] +synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] +synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] +synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] +is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0001998 +name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] +synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] +synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0001999 +name: renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure +namespace: biological_process +def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] +synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] +is_a: GO:0003014 ! renal system process +relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin + +[Term] +id: GO:0002000 +name: detection of renal blood flow +namespace: biological_process +def: "The process by which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0050982 ! detection of mechanical stimulus +relationship: part_of GO:0001999 ! renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure + +[Term] +id: GO:0002001 +name: renin secretion into blood stream +namespace: biological_process +def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "renin release into blood stream" EXACT [] +is_a: GO:0009306 ! protein secretion +relationship: part_of GO:0001999 ! renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure + +[Term] +id: GO:0002002 +name: regulation of angiotensin levels in blood +namespace: biological_process +def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph] +synonym: "control of angiotensin levels in blood" RELATED [] +synonym: "control of blood angiotensin level" RELATED [] +synonym: "regulation of blood angiotensin level" EXACT [] +is_a: GO:0010817 ! regulation of hormone levels +is_a: GO:0060177 ! regulation of angiotensin metabolic process +relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin + +[Term] +id: GO:0002003 +name: angiotensin maturation +namespace: biological_process +def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0016486 ! peptide hormone processing +is_a: GO:0051605 ! protein maturation via proteolysis +relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood + +[Term] +id: GO:0002004 +name: secretion of vasopressin during fast regulation of systemic arterial blood pressure +namespace: biological_process +def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland during fast regulation of blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "secretion of vasopressin during fast control of blood pressure" EXACT [] +is_a: GO:0030103 ! vasopressin secretion +relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin + +[Term] +id: GO:0002005 +name: angiotensin catabolic process in blood +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0044254 ! multicellular organismal protein catabolic process +relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood + +[Term] +id: GO:0002006 +name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control +namespace: biological_process +def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002007 +name: detection of hypoxic conditions in blood by chemoreceptors +namespace: biological_process +def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] +is_a: GO:0009593 ! detection of chemical stimulus +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor + +[Term] +id: GO:0002008 +name: excitation of vasomotor center by chemoreceptor signaling +namespace: biological_process +def: "The process by which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] +synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] +is_a: GO:0050877 ! neurological system process +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002009 +name: morphogenesis of an epithelium +namespace: biological_process +def: "The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0002010 +name: excitation of vasomotor center by baroreceptor signaling +namespace: biological_process +def: "The process by which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] +synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] +is_a: GO:0050877 ! neurological system process +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0002011 +name: morphogenesis of an epithelial sheet +namespace: biological_process +def: "The process by which the anatomical structures of an epithelial sheet are generated and organized. Morphogenesis pertains to the creation of form. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0002012 +name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002013 +name: detection of carbon dioxide by vasomotor center +namespace: biological_process +def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0003031 ! detection of carbon dioxide +relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions + +[Term] +id: GO:0002014 +name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002015 +name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback +namespace: biological_process +def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] +synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "atrial control of blood pressure" RELATED [] +synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] +synonym: "atrial reflex" RELATED [GOC:dph] +is_a: GO:0003015 ! heart process +relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback + +[Term] +id: GO:0002016 +name: regulation of blood volume by renin-angiotensin +namespace: biological_process +def: "The process by which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "renin-angiotensin control of body fluid levels" RELATED [] +synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin + +[Term] +id: GO:0002017 +name: regulation of blood volume by renal aldosterone +namespace: biological_process +def: "The process by which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "aldosterone mediated control of body fluids" RELATED [] +synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] +synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001977 ! regulation of blood volume by renal system process +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002018 +name: renin-angiotensin regulation of aldosterone production +namespace: biological_process +def: "The process by which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "renin-angiotensin control of aldosterone production" RELATED [] +is_a: GO:0003014 ! renal system process +relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin + +[Term] +id: GO:0002019 +name: regulation of renal output by angiotensin +namespace: biological_process +def: "The process by which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "angiotensin mediated control of renal output" RELATED [] +synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin + +[Term] +id: GO:0002020 +name: protease binding +namespace: molecular_function +def: "Interacting selectively with any protease or peptidase." [GOC:hjd] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0002021 +name: response to dietary excess +namespace: biological_process +def: "The physiological process by which dietary excess is sensed by the central nervous system and results in a reduction in food intake and increased energy expenditure." [PMID:12161655] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0050896 ! response to stimulus +relationship: part_of GO:0040014 ! regulation of multicellular organism growth + +[Term] +id: GO:0002022 +name: detection of dietary excess +namespace: biological_process +def: "The mechanism by which the brain senses excessive caloric intake." [PMID:12161655] +is_a: GO:0050877 ! neurological system process +relationship: part_of GO:0002021 ! response to dietary excess + +[Term] +id: GO:0002023 +name: reduction of food intake in response to dietary excess +namespace: biological_process +def: "The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food." [PMID:12161655] +is_a: GO:0042755 ! eating behavior +relationship: part_of GO:0002021 ! response to dietary excess + +[Term] +id: GO:0002024 +name: diet induced thermogenesis +namespace: biological_process +def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] +is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process +relationship: part_of GO:0002021 ! response to dietary excess + +[Term] +id: GO:0002025 +name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] +synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] +synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine +relationship: part_of GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0002026 +name: regulation of the force of heart contraction +namespace: biological_process +def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] +synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] +synonym: "heart inotropy" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0002027 +name: regulation of heart rate +namespace: biological_process +def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] +synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of heart contraction rate" EXACT [] +synonym: "regulation of rate of heart contraction" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0002028 +name: regulation of sodium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells." [GOC:dph] +synonym: "regulation of Na+ transport" EXACT [] +synonym: "regulation of sodium transport" EXACT [] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0002029 +name: desensitization of G-protein coupled receptor protein signaling pathway +namespace: biological_process +def: "The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717] +synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] +is_a: GO:0022401 ! adaptation of signaling pathway +is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0002030 +name: inhibitory G-protein coupled receptor phosphorylation +namespace: biological_process +def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] +is_a: GO:0006468 ! protein amino acid phosphorylation +relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0002031 +name: G-protein coupled receptor internalization +namespace: biological_process +def: "The process by which a G-protein coupled receptor is taken up into an endocytic vesicle." [PMID:8396717] +is_a: GO:0031623 ! receptor internalization +relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0002032 +name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin +namespace: biological_process +def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] +synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] +is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0002033 +name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951 "Principles of Physiology", PMID:10425188] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin +relationship: part_of GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0002034 +name: regulation of blood vessel size by renin-angiotensin +namespace: biological_process +def: "The process where the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb] +synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003072 ! regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin +is_a: GO:0050880 ! regulation of blood vessel size + +[Term] +id: GO:0002035 +name: brain renin-angiotensin system +namespace: biological_process +def: "The process by which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process +is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin + +[Term] +id: GO:0002036 +name: regulation of L-glutamate transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd] +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0015813 ! L-glutamate transport + +[Term] +id: GO:0002037 +name: negative regulation of L-glutamate transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd] +synonym: "down regulation of L-glutamate transport" EXACT [] +synonym: "down-regulation of L-glutamate transport" EXACT [] +synonym: "downregulation of L-glutamate transport" EXACT [] +synonym: "inhibition of L-glutamate transport" NARROW [] +is_a: GO:0002036 ! regulation of L-glutamate transport +is_a: GO:0051956 ! negative regulation of amino acid transport +relationship: negatively_regulates GO:0015813 ! L-glutamate transport + +[Term] +id: GO:0002038 +name: positive regulation of L-glutamate transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd] +synonym: "activation of L-glutamate transport" NARROW [] +synonym: "stimulation of L-glutamate transport" NARROW [] +synonym: "up regulation of L-glutamate transport" EXACT [] +synonym: "up-regulation of L-glutamate transport" EXACT [] +synonym: "upregulation of L-glutamate transport" EXACT [] +is_a: GO:0002036 ! regulation of L-glutamate transport +is_a: GO:0051957 ! positive regulation of amino acid transport +relationship: positively_regulates GO:0015813 ! L-glutamate transport + +[Term] +id: GO:0002039 +name: p53 binding +namespace: molecular_function +def: "Interacting selectively with one of the p53 family of proteins." [GOC:hjd] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0002040 +name: sprouting angiogenesis +namespace: biological_process +def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003] +is_a: GO:0001525 ! angiogenesis + +[Term] +id: GO:0002041 +name: intussusceptive angiogenesis +namespace: biological_process +def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] +is_a: GO:0001525 ! angiogenesis + +[Term] +id: GO:0002042 +name: cell migration during sprouting angiogenesis +namespace: biological_process +def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during sprouting angiogenesis." [PMID:16391003] +is_a: GO:0043534 ! blood vessel endothelial cell migration +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0002043 +name: blood vessel endothelial cell proliferation during sprouting angiogenesis +namespace: biological_process +def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population during sprouting angiogenesis." [PMID:16391003] +is_a: GO:0001935 ! endothelial cell proliferation +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0002044 +name: blood vessel endothelial cell migration during intussusceptive angiogenesis +namespace: biological_process +def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] +is_a: GO:0043534 ! blood vessel endothelial cell migration +relationship: part_of GO:0002041 ! intussusceptive angiogenesis + +[Term] +id: GO:0002045 +name: regulation of cell adhesion during intussusceptive angiogenesis +namespace: biological_process +def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix during intussusceptive angiogenesis." [PMID:16391003] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: part_of GO:0002041 ! intussusceptive angiogenesis + +[Term] +id: GO:0002046 +name: opsin binding +namespace: molecular_function +def: "Interacting selectively with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0002047 +name: phenazine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] +subset: gosubset_prok +synonym: "acridizine biosynthesis" RELATED [] +synonym: "acridizine biosynthetic process" RELATED [] +synonym: "azophenylene biosynthesis" RELATED [] +synonym: "azophenylene biosynthetic process" RELATED [] +synonym: "dibenzo-p-diazine biosynthesis" RELATED [] +synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] +synonym: "dibenzopyrazine biosynthesis" RELATED [] +synonym: "dibenzopyrazine biosynthetic process" RELATED [] +is_a: GO:0017000 ! antibiotic biosynthetic process + +[Term] +id: GO:0002048 +name: pyoverdine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] +synonym: "pyoverdine metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0002049 +name: pyoverdine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] +is_a: GO:0002048 ! pyoverdine metabolic process +is_a: GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0002050 +name: pyoverdine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] +is_a: GO:0002048 ! pyoverdine metabolic process +is_a: GO:0046215 ! siderophore catabolic process + +[Term] +id: GO:0002051 +name: osteoblast fate commitment +namespace: biological_process +def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0002052 +name: positive regulation of neuroblast proliferation +namespace: biological_process +def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] +synonym: "activation of neuroblast proliferation" NARROW [] +synonym: "stimulation of neuroblast proliferation" NARROW [] +synonym: "up regulation of neuroblast proliferation" EXACT [] +synonym: "up-regulation of neuroblast proliferation" EXACT [] +synonym: "upregulation of neuroblast proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +relationship: positively_regulates GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:0002053 +name: positive regulation of mesenchymal cell proliferation +namespace: biological_process +def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] +synonym: "activation of mesenchymal cell proliferation" NARROW [] +synonym: "stimulation of mesenchymal cell proliferation" NARROW [] +synonym: "up regulation of mesenchymal cell proliferation" EXACT [] +synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] +synonym: "upregulation of mesenchymal cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation + +[Term] +id: GO:0002054 +name: nucleobase binding +namespace: molecular_function +def: "Interacting selectively with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0002055 +name: adenine binding +namespace: molecular_function +def: "Interacting selectively with adenine, a purine base." [GOC:hjd] +synonym: "6-aminopurine binding" EXACT [] +is_a: GO:0002060 ! purine binding + +[Term] +id: GO:0002056 +name: cytosine binding +namespace: molecular_function +def: "Interactiing selectively with cytosine." [GOC:hjd] +is_a: GO:0002061 ! pyrimidine binding + +[Term] +id: GO:0002057 +name: guanine binding +namespace: molecular_function +def: "Interacting selectively with guanine." [GOC:hjd] +is_a: GO:0002060 ! purine binding + +[Term] +id: GO:0002058 +name: uracil binding +namespace: molecular_function +def: "Interacting selectively with uracil." [GOC:hjd] +is_a: GO:0002061 ! pyrimidine binding + +[Term] +id: GO:0002059 +name: thymine binding +namespace: molecular_function +def: "Interacting selectively with thymine." [GOC:hjd] +is_a: GO:0002061 ! pyrimidine binding + +[Term] +id: GO:0002060 +name: purine binding +namespace: molecular_function +def: "Interacting selectively with a purine, an organic nitrogenous base." [GOC:hjd] +is_a: GO:0002054 ! nucleobase binding + +[Term] +id: GO:0002061 +name: pyrimidine binding +namespace: molecular_function +def: "Interacting selectively with a pyrimidine, an organic nitrogenous base." [GOC:hjd] +synonym: "1,3-diazine binding" EXACT [] +is_a: GO:0002054 ! nucleobase binding + +[Term] +id: GO:0002062 +name: chondrocyte differentiation +namespace: biological_process +def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0051216 ! cartilage development + +[Term] +id: GO:0002063 +name: chondrocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0002064 +name: epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0002065 +name: columnar/cuboidal epithelial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0002066 +name: columnar/cuboidal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation + +[Term] +id: GO:0002067 +name: glandular epithelial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation + +[Term] +id: GO:0002068 +name: glandular epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002066 ! columnar/cuboidal epithelial cell development +relationship: part_of GO:0002067 ! glandular epithelial cell differentiation + +[Term] +id: GO:0002069 +name: columnar/cuboidal epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0002070 ! epithelial cell maturation +relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development + +[Term] +id: GO:0002070 +name: epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0002064 ! epithelial cell development + +[Term] +id: GO:0002071 +name: glandular epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation +relationship: part_of GO:0002068 ! glandular epithelial cell development + +[Term] +id: GO:0002072 +name: optic cup morphogenesis involved in camera-type eye development +namespace: biological_process +def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina." [GOC:dph, GOC:mtg_sensu, ISBN:0878932437] +synonym: "optic cup morphogenesis (sensu Mammalia)" EXACT [] +synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0002074 +name: extraocular skeletal muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] +synonym: "extraocular skeletal muscle development (sensu Mammalia)" EXACT [] +is_a: GO:0007519 ! skeletal muscle development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0002075 +name: somitomeric trunk muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:dph, PMID:16638982] +synonym: "somitomeric trunk muscle development (sensu Mammalia)" NARROW [] +is_a: GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0002076 +name: osteoblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0002077 +name: acrosome matrix dispersal +namespace: biological_process +def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029] +is_a: GO:0006508 ! proteolysis +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0002078 +name: membrane fusion during acrosome reaction +namespace: biological_process +def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] +synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] +is_a: GO:0006944 ! membrane fusion +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0002079 +name: inner acrosomal membrane +namespace: cellular_component +def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] +comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. +is_a: GO:0044425 ! membrane part +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0002080 ! acrosomal membrane + +[Term] +id: GO:0002080 +name: acrosomal membrane +namespace: cellular_component +def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0001669 ! acrosome + +[Term] +id: GO:0002081 +name: outer acrosomal membrane +namespace: cellular_component +def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] +comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. +is_a: GO:0044425 ! membrane part +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0002080 ! acrosomal membrane + +[Term] +id: GO:0002082 +name: regulation of oxidative phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0002083 +name: 4-hydroxybenzoate decaprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: decaprenyl-PP + p-hydroxybenzoate = decaprenyl-4-hydroxybenzoate + diphosphate." [GOC:hjd] +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0002084 +name: protein depalmitoylation +namespace: biological_process +def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] +is_a: GO:0006464 ! protein modification process +is_a: GO:0042159 ! lipoprotein catabolic process + +[Term] +id: GO:0002085 +name: repression of premature neural plate formation +namespace: biological_process +def: "The process that prevents cells of the epiblast from differentiating into neuroepithelial cells before the appropriate time." [GOC:dph, PMID:16678814] +synonym: "negative regulation of neural plate biosynthesis" EXACT [] +synonym: "negative regulation of neural plate formation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0048505 ! regulation of timing of cell differentiation +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0002086 +name: diaphragm contraction +namespace: biological_process +def: "A process whereby force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] +is_a: GO:0003011 ! involuntary skeletal muscle contraction +is_a: GO:0003016 ! respiratory system process +relationship: part_of GO:0010802 ! respiratory gaseous exchange by respiratory system + +[Term] +id: GO:0002087 +name: regulation of respiratory gaseous exchange by neurological process +namespace: biological_process +def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] +synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043576 ! regulation of respiratory gaseous exchange +is_a: GO:0050877 ! neurological system process +relationship: regulates GO:0010802 ! respiratory gaseous exchange by respiratory system + +[Term] +id: GO:0002088 +name: lens development in camera-type eye +namespace: biological_process +def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina." [GOC:dph, ISBN:0582064333] +synonym: "lens development (sensu Vertebrata)" EXACT [] +synonym: "lens development in camera-style eye" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0002089 +name: lens morphogenesis in camera-type eye +namespace: biological_process +def: "The process by which the anatomical structures of the lens are generated and organized. Morphogenesis pertains to the creation of form. The lens is a transparent structure in the eye through which light is focused onto the retina." [GOC:dph, GOC:mtg_sensu] +synonym: "lens morphogenesis (sensu Vertebrata)" EXACT [] +synonym: "lens morphogenesis in camera-style eye" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0002088 ! lens development in camera-type eye +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0002090 +name: regulation of receptor internalization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: regulates GO:0031623 ! receptor internalization + +[Term] +id: GO:0002091 +name: negative regulation of receptor internalization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] +synonym: "down regulation of receptor internalization" EXACT [] +synonym: "down-regulation of receptor internalization" EXACT [] +synonym: "downregulation of receptor internalization" EXACT [] +synonym: "inhibition of receptor internalization" NARROW [] +is_a: GO:0002090 ! regulation of receptor internalization +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis +relationship: negatively_regulates GO:0031623 ! receptor internalization + +[Term] +id: GO:0002092 +name: positive regulation of receptor internalization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] +synonym: "activation of receptor internalization" NARROW [] +synonym: "stimulation of receptor internalization" NARROW [] +synonym: "up regulation of receptor internalization" EXACT [] +synonym: "up-regulation of receptor internalization" EXACT [] +synonym: "upregulation of receptor internalization" EXACT [] +is_a: GO:0002090 ! regulation of receptor internalization +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis +relationship: positively_regulates GO:0031623 ! receptor internalization + +[Term] +id: GO:0002093 +name: auditory receptor cell morphogenesis +namespace: biological_process +def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] +synonym: "hair cell morphogenesis" BROAD [GO:dph] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0060117 ! auditory receptor cell development + +[Term] +id: GO:0002094 +name: polyprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] +subset: gosubset_prok +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0002095 +name: caveolar macromolecular signaling complex +namespace: cellular_component +def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] +synonym: "caveolar macromolecular signalling complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005901 ! caveola + +[Term] +id: GO:0002096 +name: polkadots +namespace: cellular_component +def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] +comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0002097 +name: tRNA wobble base modification +namespace: biological_process +def: "The process whereby the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0002098 +name: tRNA wobble uridine modification +namespace: biological_process +def: "The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002099 +name: tRNA wobble guanine modification +namespace: biological_process +def: "The process whereby a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002100 +name: tRNA wobble adenosine to inosine editing +namespace: biological_process +def: "The process whereby an adenosine in position 34 of a tRNA is post-transcriptionally corverted to inosine." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002101 +name: tRNA wobble cytosine modification +namespace: biological_process +def: "The process whereby a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002102 +name: podosome +namespace: cellular_component +def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] +comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0002103 +name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing + +[Term] +id: GO:0002104 +name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) + +[Term] +id: GO:0002105 +name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) + +[Term] +id: GO:0002106 +name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) + +[Term] +id: GO:0002107 +name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III +namespace: biological_process +def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] +is_a: GO:0000481 ! maturation of 5S rRNA +is_a: GO:0031125 ! rRNA 3'-end processing + +[Term] +id: GO:0002108 +name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0002109 +name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0002110 +name: cotranscriptional mitochondrial rRNA nucleotide insertion +namespace: biological_process +def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA", PMID:8306965] +is_a: GO:0000154 ! rRNA modification +is_a: GO:0016552 ! cotranscriptional insertion or deletion editing + +[Term] +id: GO:0002111 +name: BRCA2-BRAF35 complex +namespace: cellular_component +def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0002112 +name: interleukin-33 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-33 receptor." [GOC:hjd] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0002113 +name: interleukin-33 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-33." [GOC:hjd] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0002114 +name: interleukin-33 receptor activity +namespace: molecular_function +def: "Combining with interleukin-33 to initiate a change in cell activity." [GOC:hjd] +is_a: GO:0002113 ! interleukin-33 binding +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0002115 +name: store-operated calcium entry +namespace: biological_process +def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] +comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2) , inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. +synonym: "calcium ion import" BROAD [] +synonym: "capacitative calcium entry" EXACT [] +synonym: "SOCE" EXACT [] +synonym: "store-operated calcium import" EXACT [] +is_a: GO:0006816 ! calcium ion transport + +[Term] +id: GO:0002116 +name: semaphorin receptor complex +namespace: cellular_component +def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] +synonym: "plexin-neurophilin complex" EXACT [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0002117 +name: amphibian larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:go_curators, GOC:rf, http://www.livingunderworld.org/biology/] +synonym: "larval development (sensu Amphibia)" EXACT [] +is_a: GO:0002164 ! larval development + +[Term] +id: GO:0002118 +name: aggressive behavior +namespace: biological_process +def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] +synonym: "aggression" EXACT [] +is_a: GO:0051705 ! behavioral interaction between organisms + +[Term] +id: GO:0002119 +name: nematode larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (fr example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] +synonym: "larval development (sensu Nematoda)" EXACT [] +is_a: GO:0002164 ! larval development + +[Term] +id: GO:0002120 +name: predatory aggressive behavior +namespace: biological_process +def: "Aggressive behavior involving attack on prey by a predator, characterized by lack of threatening displays, silence, and no sex differences." [GOC:hjd] +synonym: "predatory aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002121 +name: inter-male aggressive behavior +namespace: biological_process +def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] +synonym: "inter-male aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002122 +name: fear-induced aggressive behavior +namespace: biological_process +def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] +synonym: "fear-induced aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002123 +name: irritable aggressive behavior +namespace: biological_process +def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] +synonym: "irritable aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002124 +name: territorial aggressive behavior +namespace: biological_process +def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] +synonym: "territorial aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002125 +name: maternal aggressive behavior +namespace: biological_process +def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] +comment: Paternal aggression also exists. Serves to protect the offspring from intruders. +synonym: "maternal aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002126 +name: instrumental aggressive behavior +namespace: biological_process +def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] +synonym: "instrumental aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002164 +name: larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0002165 +name: instar larval or pupal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure." [GOC:jic, GOC:mtg_sensu] +synonym: "larval or pupal development (sensu Insecta)" EXACT [] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0002168 +name: instar larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage." [GOC:bf, GOC:mtg_sensu] +synonym: "larval development (sensu Insecta)" EXACT [] +is_a: GO:0002164 ! larval development +is_a: GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0002200 +name: somatic diversification of immune receptors +namespace: biological_process +def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509] +comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0002520 ! immune system development + +[Term] +id: GO:0002201 +name: somatic diversification of DSCAM-based immune receptors +namespace: biological_process +def: "The somatic process by means of which sequence diversity of the DSCAM-based immune receptors of insects is generated." [GOC:add, PMID:16261174] +comment: Note that this type of immune receptor may not be limited to insects. +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002202 +name: somatic diversification of variable lymphocyte receptors of jawless fish +namespace: biological_process +def: "The somatic process by means of which sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish is generated." [GOC:add, PMID:16373579] +comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002203 +name: proteolysis by cytosolic proteases associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] +comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002204 +name: somatic recombination of immunoglobulin genes during immune response +namespace: biological_process +def: "The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic recombination of antibody genes during immune response" EXACT [] +is_a: GO:0002208 ! somatic diversification of immunoglobulins during immune response +is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments + +[Term] +id: GO:0002205 +name: somatic hypermutation of immunoglobulin genes during immune response +namespace: biological_process +def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205333, PMID:14991701] +synonym: "somatic hypermutation of antibody genes during immune response" EXACT [] +is_a: GO:0002208 ! somatic diversification of immunoglobulins during immune response +is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes +relationship: part_of GO:0002344 ! B cell affinity maturation + +[Term] +id: GO:0002206 +name: gene conversion of immunoglobulin genes +namespace: biological_process +def: "The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] +synonym: "gene conversion of antibody genes" EXACT [] +is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0002207 +name: gene conversion of immunoglobulin genes during immune response +namespace: biological_process +def: "The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of an immune response." [GOC:add, PMID:14991701] +synonym: "gene conversion of antibody genes during immune response" EXACT [] +is_a: GO:0002206 ! gene conversion of immunoglobulin genes +is_a: GO:0002208 ! somatic diversification of immunoglobulins during immune response + +[Term] +id: GO:0002208 +name: somatic diversification of immunoglobulins during immune response +namespace: biological_process +def: "The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14991701] +synonym: "somatic diversification of antibodies during immune response" EXACT [] +is_a: GO:0016445 ! somatic diversification of immunoglobulins +relationship: part_of GO:0002381 ! immunoglobulin production during immune response + +[Term] +id: GO:0002209 +name: behavioral defense response +namespace: biological_process +def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GOC:add, GOC:mtg_15nov05] +comment: This term was added by GO_REF:0000022. +synonym: "behavioural defense response" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0002210 +name: behavioral response to wounding +namespace: biological_process +def: "A behavioral response resulting from wounding." [GOC:add, GOC:mtg_15nov05] +comment: This term was added by GO_REF:0000022. +synonym: "behavioural response to wounding" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0002211 +name: behavioral defense response to insect +namespace: biological_process +def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] +synonym: "behavioural defense response to insect" EXACT [] +is_a: GO:0002209 ! behavioral defense response +is_a: GO:0002213 ! defense response to insect + +[Term] +id: GO:0002212 +name: behavioral defense response to nematode +namespace: biological_process +def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] +synonym: "behavioural defense response to nematode" EXACT [] +is_a: GO:0002209 ! behavioral defense response +is_a: GO:0002215 ! defense response to nematode + +[Term] +id: GO:0002213 +name: defense response to insect +namespace: biological_process +alt_id: GO:0002214 +def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] +synonym: "physiological defense response to insect" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0009625 ! response to insect + +[Term] +id: GO:0002215 +name: defense response to nematode +namespace: biological_process +alt_id: GO:0002216 +def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] +synonym: "physiological defense response to nematode" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0009624 ! response to nematode + +[Term] +id: GO:0002218 +name: activation of innate immune response +namespace: biological_process +alt_id: GO:0002219 +def: "Any process that initiates an innate immune response." [GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:16177805] +comment: This term was added by GO_REF:0000022. +synonym: "activation of innate immune response (sensu Viridiplantae)" RELATED [] +is_a: GO:0002253 ! activation of immune response +is_a: GO:0045089 ! positive regulation of innate immune response + +[Term] +id: GO:0002220 +name: innate immune response activating cell surface receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] +synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] +synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway +is_a: GO:0002758 ! innate immune response-activating signal transduction + +[Term] +id: GO:0002221 +name: pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] +synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] +synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] +synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] +synonym: "PRR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] +is_a: GO:0002758 ! innate immune response-activating signal transduction + +[Term] +id: GO:0002222 +name: stimulatory killer cell immunoglobulin-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] +synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway + +[Term] +id: GO:0002223 +name: stimulatory C-type lectin receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] +synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway + +[Term] +id: GO:0002224 +name: toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] +comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. +synonym: "TLR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"] +synonym: "toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0002225 +name: positive regulation of antimicrobial peptide production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] +synonym: "activation of antimicrobial peptide production" NARROW [] +synonym: "antimicrobial peptide induction" EXACT [] +synonym: "stimulation of antimicrobial peptide production" NARROW [] +synonym: "up regulation of antimicrobial peptide production" EXACT [] +synonym: "up-regulation of antimicrobial peptide production" EXACT [] +synonym: "upregulation of antimicrobial peptide production" EXACT [] +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:0002784 ! regulation of antimicrobial peptide production +relationship: positively_regulates GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002227 +name: innate immune response in mucosa +namespace: biological_process +def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] +is_a: GO:0002385 ! mucosal immune response +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0002228 +name: natural killer cell mediated immunity +namespace: biological_process +def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "NK cell mediated immunity" EXACT [] +is_a: GO:0002449 ! lymphocyte mediated immunity +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0002229 +name: defense response to oomycetes +namespace: biological_process +def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] +is_a: GO:0002239 ! response to oomycetes +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0002230 +name: positive regulation of defense response to virus by host +namespace: biological_process +def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of antiviral response by host" NARROW [] +synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of antiviral response by host" NARROW [] +synonym: "up regulation of antiviral response by host" EXACT [] +synonym: "up-regulation of antiviral response by host" EXACT [] +synonym: "upregulation of antiviral response by host" EXACT [] +is_a: GO:0050691 ! regulation of defense response to virus by host + +[Term] +id: GO:0002231 +name: detection of oomycetes +namespace: biological_process +def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] +is_a: GO:0002239 ! response to oomycetes +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0002232 +name: leukocyte chemotaxis during inflammatory response +namespace: biological_process +def: "The movement of an immune cell in response to an external stimulus during an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune cell chemotaxis during inflammatory response" EXACT [] +synonym: "leucocyte chemotaxis during inflammatory response" EXACT [] +is_a: GO:0002523 ! leukocyte migration during inflammatory response +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002233 +name: leukocyte chemotaxis during immune response +namespace: biological_process +def: "The movement of an immune cell in response to an external stimulus during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune cell chemotaxis during immune response" EXACT [] +synonym: "leucocyte chemotaxis during immune response" EXACT [] +is_a: GO:0002522 ! leukocyte migration during immune response +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002234 +name: detection of endoplasmic reticulum overloading +namespace: biological_process +def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] +synonym: "detection of ER overloading" EXACT [] +is_a: GO:0006983 ! ER overload response +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0002235 +name: detection of unfolded protein +namespace: biological_process +def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] +is_a: GO:0006986 ! response to unfolded protein +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0002236 +name: detection of misfolded protein +namespace: biological_process +def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0051788 ! response to misfolded protein + +[Term] +id: GO:0002237 +name: response to molecule of bacterial origin +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] +synonym: "response to bacteria associated molecule" EXACT [] +synonym: "response to bacterial associated molecule" EXACT [] +synonym: "response to bacterium associated molecule" EXACT [] +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0042221 ! response to chemical stimulus +relationship: part_of GO:0009617 ! response to bacterium + +[Term] +id: GO:0002238 +name: response to molecule of fungal origin +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octomer oligosaccharide." [GOC:rl, GOC:sm] +synonym: "response to fungus associated molecule" EXACT [] +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0042221 ! response to chemical stimulus +relationship: part_of GO:0009620 ! response to fungus + +[Term] +id: GO:0002239 +name: response to oomycetes +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0002240 +name: response to molecule of oomycetes origin +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] +synonym: "response to oomycetes associated molecule" EXACT [] +is_a: GO:0009607 ! response to biotic stimulus +relationship: part_of GO:0002239 ! response to oomycetes + +[Term] +id: GO:0002241 +name: response to parasitic plant +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] +is_a: GO:0009608 ! response to symbiont + +[Term] +id: GO:0002242 +name: defense response to parasitic plant +namespace: biological_process +def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] +is_a: GO:0002241 ! response to parasitic plant +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0002243 +name: detection of parasitic plant +namespace: biological_process +def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] +is_a: GO:0002241 ! response to parasitic plant +is_a: GO:0009602 ! detection of symbiont + +[Term] +id: GO:0002244 +name: hemopoietic progenitor cell differentiation +namespace: biological_process +def: "The process whereby precursor cell type acquires the specialized features of a hemopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551251] +synonym: "haematopoietic progenitor cell differentiation" EXACT [] +synonym: "haemopoietic progenitor cell differentiation" EXACT [] +synonym: "hematopoietic progenitor cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0002246 +name: healing during inflammatory response +namespace: biological_process +def: "The series of events that restore integrity to damaged tissue during or following an inflammatory response." [GOC:jal, ISBN:0721601871] +is_a: GO:0042060 ! wound healing +relationship: part_of GO:0006954 ! inflammatory response + +[Term] +id: GO:0002247 +name: clearance of damaged tissue during inflammatory response +namespace: biological_process +def: "The series of events leading to removal of necrotic debris during or following an inflammatory response." [GOC:jal, ISBN:0721601871] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0002246 ! healing during inflammatory response + +[Term] +id: GO:0002248 +name: connective tissue replacement during inflammatory response +namespace: biological_process +def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared during or following an inflammatory response." [GOC:jal, ISBN:0721601871] +synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0002246 ! healing during inflammatory response + +[Term] +id: GO:0002249 +name: lymphocyte anergy +namespace: biological_process +def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002250 +name: adaptive immune response +namespace: biological_process +def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "acquired immune response" EXACT [ISBN:068340007X "Stedman's Medical Dictionary"] +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002251 +name: organ or tissue specific immune response +namespace: biological_process +def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GOC:jal, GOC:mtg_15nov05] +comment: This term was added by GO_REF:0000022. +synonym: "immune response in organ or tissue" EXACT [] +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002252 +name: immune effector process +namespace: biological_process +def: "Any process of the immune system that occurs as part of an immune response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0002253 +name: activation of immune response +namespace: biological_process +def: "Any process that initiates an immune response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002376 ! immune system process +is_a: GO:0050778 ! positive regulation of immune response + +[Term] +id: GO:0002254 +name: kinin cascade +namespace: biological_process +def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002255 +name: tissue kallikrein-kinin cascade +namespace: biological_process +def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] +synonym: "glandular kallikrein-kinin cascade" EXACT [] +is_a: GO:0002254 ! kinin cascade + +[Term] +id: GO:0002256 +name: regulation of kinin cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] +is_a: GO:0002673 ! regulation of acute inflammatory response +relationship: regulates GO:0002254 ! kinin cascade + +[Term] +id: GO:0002257 +name: negative regulation of kinin cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] +synonym: "down regulation of kinin cascade" EXACT [] +synonym: "down-regulation of kinin cascade" EXACT [] +synonym: "downregulation of kinin cascade" EXACT [] +synonym: "inhibition of kinin cascade" NARROW [] +is_a: GO:0002256 ! regulation of kinin cascade +is_a: GO:0002674 ! negative regulation of acute inflammatory response +relationship: negatively_regulates GO:0002254 ! kinin cascade + +[Term] +id: GO:0002258 +name: positive regulation of kinin cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] +synonym: "activation of kinin cascade" NARROW [] +synonym: "stimulation of kinin cascade" NARROW [] +synonym: "up regulation of kinin cascade" EXACT [] +synonym: "up-regulation of kinin cascade" EXACT [] +synonym: "upregulation of kinin cascade" EXACT [] +is_a: GO:0002256 ! regulation of kinin cascade +is_a: GO:0002675 ! positive regulation of acute inflammatory response +relationship: positively_regulates GO:0002254 ! kinin cascade + +[Term] +id: GO:0002259 +name: endothelial cell activation within high endothelial venule during immune response +namespace: biological_process +def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002264 ! endothelial cell activation during immune response + +[Term] +id: GO:0002260 +name: lymphocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] +is_a: GO:0001776 ! leukocyte homeostasis + +[Term] +id: GO:0002261 +name: mucosal lymphocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] +is_a: GO:0002260 ! lymphocyte homeostasis + +[Term] +id: GO:0002262 +name: myeloid cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add] +is_a: GO:0001776 ! leukocyte homeostasis + +[Term] +id: GO:0002263 +name: cell activation during immune response +namespace: biological_process +def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0002264 +name: endothelial cell activation during immune response +namespace: biological_process +def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002263 ! cell activation during immune response +is_a: GO:0042118 ! endothelial cell activation + +[Term] +id: GO:0002265 +name: astrocyte activation during immune response +namespace: biological_process +def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] +is_a: GO:0002263 ! cell activation during immune response +is_a: GO:0048143 ! astrocyte activation + +[Term] +id: GO:0002266 +name: follicular dendritic cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0002267 +name: follicular dendritic cell activation during immune response +namespace: biological_process +def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] +is_a: GO:0002263 ! cell activation during immune response +is_a: GO:0002266 ! follicular dendritic cell activation + +[Term] +id: GO:0002268 +name: follicular dendritic cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002266 ! follicular dendritic cell activation +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0002269 +name: leukocyte activation during inflammatory response +namespace: biological_process +def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune cell activation during inflammatory response" EXACT [] +is_a: GO:0045321 ! leukocyte activation +relationship: part_of GO:0006954 ! inflammatory response + +[Term] +id: GO:0002270 +name: plasmacytoid dendritic cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002271 +name: plasmacytoid dendritic cell activation during immune response +namespace: biological_process +def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] +is_a: GO:0002270 ! plasmacytoid dendritic cell activation +is_a: GO:0002366 ! leukocyte activation during immune response + +[Term] +id: GO:0002272 +name: plasmacytoid dendritic cell differentiation during immune response +namespace: biological_process +def: "The process whereby an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell during an immune response." [GOC:add, PMID:15990333] +is_a: GO:0002271 ! plasmacytoid dendritic cell activation during immune response +is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation + +[Term] +id: GO:0002273 +name: plasmacytoid dendritic cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] +is_a: GO:0002270 ! plasmacytoid dendritic cell activation +is_a: GO:0002521 ! leukocyte differentiation + +[Term] +id: GO:0002274 +name: myeloid leukocyte activation +namespace: biological_process +def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "myeloid leucocyte activation" EXACT [] +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002275 +name: myeloid cell activation during immune response +namespace: biological_process +def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation +is_a: GO:0002366 ! leukocyte activation during immune response + +[Term] +id: GO:0002276 +name: basophil activation during immune response +namespace: biological_process +def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002275 ! myeloid cell activation during immune response +is_a: GO:0045575 ! basophil activation + +[Term] +id: GO:0002277 +name: myeloid dendritic cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001773 ! myeloid dendritic cell activation +is_a: GO:0002275 ! myeloid cell activation during immune response + +[Term] +id: GO:0002278 +name: eosinophil activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002275 ! myeloid cell activation during immune response +is_a: GO:0043307 ! eosinophil activation + +[Term] +id: GO:0002279 +name: mast cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002275 ! myeloid cell activation during immune response +is_a: GO:0045576 ! mast cell activation + +[Term] +id: GO:0002280 +name: monocyte activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551245] +is_a: GO:0002275 ! myeloid cell activation during immune response +is_a: GO:0042117 ! monocyte activation + +[Term] +id: GO:0002281 +name: macrophage activation during immune response +namespace: biological_process +def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002275 ! myeloid cell activation during immune response +is_a: GO:0042116 ! macrophage activation + +[Term] +id: GO:0002282 +name: microglial cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001774 ! microglial cell activation +is_a: GO:0002281 ! macrophage activation during immune response + +[Term] +id: GO:0002283 +name: neutrophil activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002275 ! myeloid cell activation during immune response +is_a: GO:0042119 ! neutrophil activation + +[Term] +id: GO:0002284 +name: myeloid dendritic cell differentiation during immune response +namespace: biological_process +def: "The process whereby an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002277 ! myeloid dendritic cell activation during immune response +is_a: GO:0043011 ! myeloid dendritic cell differentiation + +[Term] +id: GO:0002285 +name: lymphocyte activation during immune response +namespace: biological_process +def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002366 ! leukocyte activation during immune response +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0002286 +name: T cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte activation during immune response" EXACT [] +synonym: "T-cell activation during immune response" EXACT [] +synonym: "T-lymphocyte activation during immune response" EXACT [] +is_a: GO:0002285 ! lymphocyte activation during immune response +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0002287 +name: alpha-beta T cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "alpha-beta T lymphocyte activation during immune response" EXACT [] +synonym: "alpha-beta T-cell activation during immune response" EXACT [] +synonym: "alpha-beta T-lymphocyte activation during immune response" EXACT [] +is_a: GO:0002286 ! T cell activation during immune response +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0002288 +name: NK T cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] +synonym: "natural killer T lymphocyte activation during immune response" EXACT [] +synonym: "natural killer T-cell activation during immune response" EXACT [] +synonym: "natural killer T-lymphocyte activation during immune response" EXACT [] +synonym: "NK T lymphocyte activation during immune response" EXACT [] +synonym: "NK T-cell activation during immune response" EXACT [] +synonym: "NK T-lymphocyte activation during immune response" EXACT [] +is_a: GO:0002287 ! alpha-beta T cell activation during immune response +is_a: GO:0051132 ! NK T cell activation + +[Term] +id: GO:0002289 +name: NK T cell proliferation during immune response +namespace: biological_process +def: "The expansion of a NK T cell population by cell division during an immune response." [GOC:add, PMID:15771592] +synonym: "natural killer T lymphocyte proliferation during immune response" EXACT [] +synonym: "natural killer T-cell proliferation during immune response" EXACT [] +synonym: "natural killer T-lymphocyte proliferation during immune response" EXACT [] +synonym: "NK T lymphocyte proliferation during immune response" EXACT [] +synonym: "NK T-cell proliferation during immune response" EXACT [] +synonym: "NK T-lymphocyte proliferation during immune response" EXACT [] +is_a: GO:0001866 ! NK T cell proliferation +is_a: GO:0002288 ! NK T cell activation during immune response +is_a: GO:0002310 ! alpha-beta T cell proliferation during immune response + +[Term] +id: GO:0002290 +name: gamma-delta T cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] +synonym: "gamma-delta T lymphocyte activation during immune response" EXACT [] +synonym: "gamma-delta T-cell activation during immune response" EXACT [] +synonym: "gamma-delta T-lymphocyte activation during immune response" EXACT [] +is_a: GO:0002286 ! T cell activation during immune response +is_a: GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0002291 +name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] +synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] +synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] +is_a: GO:0002286 ! T cell activation during immune response + +[Term] +id: GO:0002292 +name: T cell differentiation during immune response +namespace: biological_process +def: "The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte differentiation during immune response" EXACT [] +synonym: "T-cell differentiation during immune response" EXACT [] +synonym: "T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002286 ! T cell activation during immune response +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002293 +name: alpha-beta T cell differentiation during immune response +namespace: biological_process +def: "The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "alpha-beta T lymphocyte differentiation during immune response" EXACT [] +synonym: "alpha-beta T-cell differentiation during immune response" EXACT [] +synonym: "alpha-beta T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002292 ! T cell differentiation during immune response +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0002294 +name: CD4-positive, alpha-beta T cell differentiation during immune response +namespace: biological_process +def: "The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" EXACT [] +synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" EXACT [] +synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002293 ! alpha-beta T cell differentiation during immune response +is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation + +[Term] +id: GO:0002295 +name: T-helper cell lineage commitment +namespace: biological_process +def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T-helper cell fate commitment" EXACT [] +synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"] +synonym: "Thp lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0002296 +name: T-helper 1 cell lineage commitment +namespace: biological_process +def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] +synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] +synonym: "Th1 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002295 ! T-helper cell lineage commitment +relationship: part_of GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0002297 +name: T-helper 2 cell lineage commitment +namespace: biological_process +def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] +synonym: "Th2 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002295 ! T-helper cell lineage commitment +relationship: part_of GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0002298 +name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response +namespace: biological_process +def: "The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell during an immune response." [GOC:add, PMID:12093005] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation during immune response +is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0002299 +name: alpha-beta intraepithelial T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] +synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0002300 +name: CD8-positive, alpha-beta intraepithelial T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0002301 +name: CD4-positive, alpha-beta intraepithelial T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation +is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation + +[Term] +id: GO:0002302 +name: CD8-positive, alpha-beta T cell differentiation during immune response +namespace: biological_process +def: "The process whereby an antigenically nave CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" EXACT [] +synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" EXACT [] +synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002293 ! alpha-beta T cell differentiation during immune response +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0002303 +name: gamma-delta T cell differentiation during immune response +namespace: biological_process +def: "The process whereby an antigenically nave gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] +synonym: "gamma-delta T lymphocyte differentiation during immune response" EXACT [] +synonym: "gamma-delta T-cell differentiation during immune response" EXACT [] +synonym: "gamma-delta T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002292 ! T cell differentiation during immune response +is_a: GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0002304 +name: gamma-delta intraepithelial T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] +synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0002305 +name: CD8-positive, gamma-delta intraepithelial T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation + +[Term] +id: GO:0002306 +name: CD4-positive gamma-delta intraepithelial T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation + +[Term] +id: GO:0002307 +name: CD8-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation +is_a: GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0002308 +name: CD8-positive, alpha-beta cytotoxic T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation +is_a: GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0002309 +name: T cell proliferation during immune response +namespace: biological_process +def: "The expansion of a T cell population by cell division during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte proliferation during immune response" EXACT [] +synonym: "T-cell proliferation during immune response" EXACT [] +synonym: "T-lymphocyte proliferation during immune response" EXACT [] +is_a: GO:0002286 ! T cell activation during immune response +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0002310 +name: alpha-beta T cell proliferation during immune response +namespace: biological_process +def: "The expansion of an alpha-beta T cell population by cell division during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "alpha-beta T lymphocyte proliferation during immune response" EXACT [] +synonym: "alpha-beta T-cell proliferation during immune response" EXACT [] +synonym: "alpha-beta T-lymphocyte proliferation during immune response" EXACT [] +is_a: GO:0002287 ! alpha-beta T cell activation during immune response +is_a: GO:0002309 ! T cell proliferation during immune response +is_a: GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0002311 +name: gamma-delta T cell proliferation during immune response +namespace: biological_process +def: "The expansion of a gamma-delta T cell population by cell division during an immune response." [GOC:add] +synonym: "gamma-delta T lymphocyte proliferation during immune response" EXACT [] +synonym: "gamma-delta T-cell proliferation during immune response" EXACT [] +synonym: "gamma-delta T-lymphocyte proliferation during immune response" EXACT [] +is_a: GO:0002309 ! T cell proliferation during immune response +is_a: GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0002312 +name: B cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] +synonym: "B lymphocyte activation during immune response" EXACT [] +synonym: "B-cell activation during immune response" EXACT [] +synonym: "B-lymphocyte activation during immune response" EXACT [] +is_a: GO:0002285 ! lymphocyte activation during immune response +is_a: GO:0042113 ! B cell activation + +[Term] +id: GO:0002313 +name: mature B cell differentiation during immune response +namespace: biological_process +def: "The process whereby a nave B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] +synonym: "mature B lymphocyte differentiation during immune response" EXACT [] +synonym: "mature B-cell differentiation during immune response" EXACT [] +synonym: "mature B-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0002312 ! B cell activation during immune response +is_a: GO:0002335 ! mature B cell differentiation + +[Term] +id: GO:0002314 +name: germinal center B cell differentiation +namespace: biological_process +def: "The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "germinal center B lymphocyte differentiation" EXACT [] +synonym: "germinal center B-cell differentiation" EXACT [] +synonym: "germinal center B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation during immune response + +[Term] +id: GO:0002315 +name: marginal zone B cell differentiation +namespace: biological_process +def: "The process whereby a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "marginal zone B lymphocyte differentiation" EXACT [] +synonym: "marginal zone B-cell differentiation" EXACT [] +synonym: "marginal zone B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation during immune response + +[Term] +id: GO:0002316 +name: follicular B cell differentiation +namespace: biological_process +def: "The process whereby a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "follicular B lymphocyte differentiation" EXACT [] +synonym: "follicular B-cell differentiation" EXACT [] +synonym: "follicular B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation during immune response + +[Term] +id: GO:0002317 +name: plasma cell differentiation +namespace: biological_process +def: "The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] +is_a: GO:0002313 ! mature B cell differentiation during immune response + +[Term] +id: GO:0002318 +name: myeloid progenitor cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] +is_a: GO:0002244 ! hemopoietic progenitor cell differentiation + +[Term] +id: GO:0002319 +name: memory B cell differentiation +namespace: biological_process +def: "The process whereby a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "memory B lymphocyte differentiation" EXACT [] +synonym: "memory B-cell differentiation" EXACT [] +synonym: "memory B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation during immune response + +[Term] +id: GO:0002320 +name: lymphoid progenitor cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] +is_a: GO:0002244 ! hemopoietic progenitor cell differentiation + +[Term] +id: GO:0002321 +name: natural killer cell progenitor differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] +is_a: GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:0002322 +name: B cell proliferation during immune response +namespace: biological_process +def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] +synonym: "B lymphocyte proliferation during immune response" EXACT [] +synonym: "B-cell proliferation during immune response" EXACT [] +synonym: "B-lymphocyte proliferation during immune response" EXACT [] +is_a: GO:0002312 ! B cell activation during immune response +is_a: GO:0042100 ! B cell proliferation + +[Term] +id: GO:0002323 +name: natural killer cell activation during immune response +namespace: biological_process +def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] +synonym: "NK cell activation during immune response" EXACT [] +is_a: GO:0002285 ! lymphocyte activation during immune response +is_a: GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0002324 +name: natural killer cell proliferation during immune response +namespace: biological_process +def: "The expansion of a natural killer cell population by cell division during an immune response." [GOC:add, PMID:15032583] +synonym: "NK cell proliferation during immune response" EXACT [] +is_a: GO:0001787 ! natural killer cell proliferation +is_a: GO:0002323 ! natural killer cell activation during immune response + +[Term] +id: GO:0002325 +name: natural killer cell differentiation during immune response +namespace: biological_process +def: "The process whereby a nave natural killer cell acquires the specialized features of an effector natural killer T cell during an immune response." [GOC:add, PMID:11698225] +synonym: "NK cell differentiation during immune response" EXACT [] +is_a: GO:0001779 ! natural killer cell differentiation +is_a: GO:0002323 ! natural killer cell activation during immune response + +[Term] +id: GO:0002326 +name: B cell lineage commitment +namespace: biological_process +def: "The process whereby a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B lymphocyte lineage commitment" EXACT [] +synonym: "B-cell lineage commitment" EXACT [] +synonym: "B-lymphocyte lineage commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002327 +name: immature B cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551251] +synonym: "immature B lymphocyte differentiation" EXACT [] +synonym: "immature B-cell differentiation" EXACT [] +synonym: "immature B-lymphocyte differentiation" EXACT [] +is_a: GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002328 +name: pro-B cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "pro-B lymphocyte differentiation" EXACT [] +is_a: GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:0002329 +name: pre-B cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "pre-B lymphocyte differentiation" EXACT [] +is_a: GO:0002327 ! immature B cell differentiation + +[Term] +id: GO:0002330 +name: pre-B cell receptor expression +namespace: biological_process +def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002329 ! pre-B cell differentiation + +[Term] +id: GO:0002331 +name: pre-B cell allelic exclusion +namespace: biological_process +def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "pre-B lymphocyte allelic exclusion" EXACT [] +is_a: GO:0002329 ! pre-B cell differentiation + +[Term] +id: GO:0002332 +name: transitional stage B cell differentiation +namespace: biological_process +def: "The process whereby immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "transitional stage B lymphocyte differentiation" EXACT [] +synonym: "transitional stage B-cell differentiation" EXACT [] +synonym: "transitional stage B-lymphocyte differentiation" EXACT [] +is_a: GO:0002327 ! immature B cell differentiation + +[Term] +id: GO:0002333 +name: transitional one stage B cell differentiation +namespace: biological_process +def: "The process whereby immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T1 stage B cell differentiation" EXACT [] +synonym: "transitional one stage B lymphocyte differentiation" EXACT [] +synonym: "transitional one stage B-cell differentiation" EXACT [] +synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] +is_a: GO:0002332 ! transitional stage B cell differentiation + +[Term] +id: GO:0002334 +name: transitional two stage B cell differentiation +namespace: biological_process +def: "The process whereby immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T2 stage B cell differentiation" EXACT [] +synonym: "transitional two stage B lymphocyte differentiation" EXACT [] +synonym: "transitional two stage B-cell differentiation" EXACT [] +synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] +is_a: GO:0002332 ! transitional stage B cell differentiation + +[Term] +id: GO:0002335 +name: mature B cell differentiation +namespace: biological_process +def: "The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "mature B lymphocyte differentiation" EXACT [] +synonym: "mature B-cell differentiation" EXACT [] +synonym: "mature B-lymphocyte differentiation" EXACT [] +is_a: GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002336 +name: B-1 B cell lineage commitment +namespace: biological_process +def: "The process by which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B-1 B lymphocyte lineage commitment" EXACT [] +synonym: "B-1 B-cell lineage commitment" EXACT [] +synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002326 ! B cell lineage commitment +relationship: part_of GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0002337 +name: B-1a B cell differentiation +namespace: biological_process +def: "The process whereby B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B-1a B lymphocyte differentiation" EXACT [] +synonym: "B-1a B-cell differentiation" EXACT [] +synonym: "B-1a B-lymphocyte differentiation" EXACT [] +is_a: GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0002338 +name: B-1b B cell differentiation +namespace: biological_process +def: "The process whereby B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B-1b B lymphocyte differentiation" EXACT [] +synonym: "B-1b B-cell differentiation" EXACT [] +synonym: "B-1b B-lymphocyte differentiation" EXACT [] +is_a: GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0002339 +name: B cell selection +namespace: biological_process +def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] +synonym: "B lymphocyte selection" EXACT [] +synonym: "B-cell selection" EXACT [] +synonym: "B-lymphocyte selection" EXACT [] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002340 +name: central B cell selection +namespace: biological_process +def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] +synonym: "central B lymphocyte selection" EXACT [] +synonym: "central B-cell selection" EXACT [] +synonym: "central B-lymphocyte selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002341 +name: central B cell anergy +namespace: biological_process +def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] +synonym: "central B lymphocyte anergy" EXACT [] +synonym: "central B-cell anergy" EXACT [] +synonym: "central B-lymphocyte anergy" EXACT [] +is_a: GO:0002515 ! B cell anergy +relationship: part_of GO:0002340 ! central B cell selection +relationship: part_of GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002342 +name: central B cell deletion +namespace: biological_process +def: "The deletion of B cells by apoptosis occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal] +synonym: "central B lymphocyte deletion" EXACT [] +synonym: "central B-cell deletion" EXACT [] +synonym: "central B-lymphocyte deletion" EXACT [] +is_a: GO:0002516 ! B cell deletion +relationship: part_of GO:0002340 ! central B cell selection +relationship: part_of GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002343 +name: peripheral B cell selection +namespace: biological_process +def: "Any B cell selection process that occurs in the periphery." [GOC:jal] +synonym: "peripheral B lymphocyte selection" EXACT [] +synonym: "peripheral B-cell selection" EXACT [] +synonym: "peripheral B-lymphocyte selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002344 +name: B cell affinity maturation +namespace: biological_process +def: "The process by which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "B lymphocyte affinity maturation" EXACT [] +synonym: "B-cell affinity maturation" EXACT [] +synonym: "B-lymphocyte affinity maturation" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +relationship: part_of GO:0002381 ! immunoglobulin production during immune response + +[Term] +id: GO:0002345 +name: peripheral B cell receptor editing +namespace: biological_process +def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] +synonym: "peripheral B lymphocyte receptor editing" EXACT [] +synonym: "peripheral B-cell receptor editing" EXACT [] +synonym: "peripheral B-lymphocyte receptor editing" EXACT [] +is_a: GO:0002452 ! B cell receptor editing + +[Term] +id: GO:0002346 +name: B cell positive selection +namespace: biological_process +def: "Any process by which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] +synonym: "B lymphocyte positive selection" EXACT [] +synonym: "B-cell positive selection" EXACT [] +synonym: "B-lymphocyte positive selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002347 +name: response to tumor cell +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002348 +name: central B cell positive selection +namespace: biological_process +def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] +synonym: "central B lymphocyte positive selection" EXACT [] +synonym: "central B-cell positive selection" EXACT [] +synonym: "central B-lymphocyte positive selection" EXACT [] +is_a: GO:0002340 ! central B cell selection +is_a: GO:0002346 ! B cell positive selection + +[Term] +id: GO:0002349 +name: histamine production during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of histamine following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response + +[Term] +id: GO:0002350 +name: peripheral B cell positive selection +namespace: biological_process +def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] +synonym: "peripheral B lymphocyte positive selection" EXACT [] +synonym: "peripheral B-cell positive selection" EXACT [] +synonym: "peripheral B-lymphocyte positive selection" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +is_a: GO:0002346 ! B cell positive selection + +[Term] +id: GO:0002351 +name: serotonin production during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of serotonin following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response + +[Term] +id: GO:0002352 +name: B cell negative selection +namespace: biological_process +def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] +synonym: "B lymphocyte negative selection" EXACT [] +synonym: "B-cell negative selection" EXACT [] +synonym: "B-lymphocyte negative selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002353 +name: plasma kallikrein-kinin cascade +namespace: biological_process +def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] +is_a: GO:0002254 ! kinin cascade + +[Term] +id: GO:0002354 +name: central B cell negative selection +namespace: biological_process +def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] +synonym: "central B lymphocyte negative selection" EXACT [] +synonym: "central B-cell negative selection" EXACT [] +synonym: "central B-lymphocyte negative selection" EXACT [] +is_a: GO:0002340 ! central B cell selection +is_a: GO:0002352 ! B cell negative selection + +[Term] +id: GO:0002355 +name: detection of tumor cell +namespace: biological_process +def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0002356 +name: peripheral B cell negative selection +namespace: biological_process +def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] +synonym: "peripheral B lymphocyte negative selection" EXACT [] +synonym: "peripheral B-cell negative selection" EXACT [] +synonym: "peripheral B-lymphocyte negative selection" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +is_a: GO:0002352 ! B cell negative selection + +[Term] +id: GO:0002357 +name: defense response to tumor cell +namespace: biological_process +def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0002358 +name: B cell homeostatic proliferation +namespace: biological_process +def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] +synonym: "B lymphocyte homeostatic proliferation" EXACT [] +synonym: "B-cell homeostatic proliferation" EXACT [] +synonym: "B-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042100 ! B cell proliferation + +[Term] +id: GO:0002359 +name: B-1 B cell proliferation +namespace: biological_process +def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] +synonym: "B-1 B lymphocyte proliferation" EXACT [] +synonym: "B-1 B-cell proliferation" EXACT [] +synonym: "B-1 B-lymphocyte proliferation" EXACT [] +is_a: GO:0042100 ! B cell proliferation + +[Term] +id: GO:0002360 +name: T cell lineage commitment +namespace: biological_process +def: "The process by which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte lineage commitment" EXACT [] +synonym: "T-cell lineage commitment" EXACT [] +synonym: "T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002361 +name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation +is_a: GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0002362 +name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment +namespace: biological_process +def: "The process by which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0002363 +name: alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process by which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "alpha-beta T-cell lineage commitment" EXACT [] +synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0002364 +name: NK T cell lineage commitment +namespace: biological_process +def: "The process by which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "natural killer T lymphocyte lineage commitment" EXACT [] +synonym: "natural killer T-cell lineage commitment" EXACT [] +synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] +synonym: "NK T lymphocyte lineage commitment" EXACT [] +synonym: "NK T-cell lineage commitment" EXACT [] +synonym: "NK T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0002365 +name: gamma-delta T cell lineage commitment +namespace: biological_process +def: "The process by which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] +synonym: "gamma-delta T-cell lineage commitment" EXACT [] +synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0002366 +name: leukocyte activation during immune response +namespace: biological_process +def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune cell activation during immune response" EXACT [] +synonym: "leucocyte activation during immune response" EXACT [] +is_a: GO:0002263 ! cell activation during immune response +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002367 +name: cytokine production during immune response +namespace: biological_process +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. +is_a: GO:0001816 ! cytokine production +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002368 +name: B cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B lymphocyte cytokine production" EXACT [] +synonym: "B-cell cytokine production" EXACT [] +synonym: "B-lymphocyte cytokine production" EXACT [] +is_a: GO:0002367 ! cytokine production during immune response +is_a: GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002369 +name: T cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte cytokine production" EXACT [] +synonym: "T-cell cytokine production" EXACT [] +synonym: "T-lymphocyte cytokine production" EXACT [] +is_a: GO:0002367 ! cytokine production during immune response +is_a: GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002370 +name: natural killer cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "NK cell cytokine production" EXACT [] +is_a: GO:0002228 ! natural killer cell mediated immunity +is_a: GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002371 +name: dendritic cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002372 +name: myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002373 +name: plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002374 +name: cytokine secretion during immune response +namespace: biological_process +def: "The regulated release of cytokines from a cell or group of cells during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0050663 ! cytokine secretion +relationship: part_of GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002375 +name: cytokine biosynthetic process during immune response +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cytokine during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002376 +name: immune system process +namespace: biological_process +def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GOC:add, GOC:mtg_15nov05] +comment: This term was added by GO_REF:0000022. +subset: goslim_pir +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0002377 +name: immunoglobulin production +namespace: biological_process +def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "antibody production" EXACT [] +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002378 +name: immunoglobulin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "antibody biosynthesis" EXACT [] +synonym: "antibody biosynthetic process" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +relationship: part_of GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002379 +name: immunoglobulin biosynthetic process during immune response +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of immunoglobulin during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "antibody biosynthesis during immune response" EXACT [] +synonym: "antibody biosynthetic process during immune response" EXACT [] +is_a: GO:0002378 ! immunoglobulin biosynthetic process +relationship: part_of GO:0002381 ! immunoglobulin production during immune response + +[Term] +id: GO:0002380 +name: immunoglobulin secretion during immune response +namespace: biological_process +def: "The regulated release of immunoglobulins from a B cell or plasma cell during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563] +synonym: "antibody secretion during immune response" EXACT [] +is_a: GO:0048305 ! immunoglobulin secretion +relationship: part_of GO:0002381 ! immunoglobulin production during immune response + +[Term] +id: GO:0002381 +name: immunoglobulin production during immune response +namespace: biological_process +def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "antibody production during immune response" EXACT [] +is_a: GO:0002377 ! immunoglobulin production +relationship: part_of GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002382 +name: regulation of tissue kallikrein-kinin cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] +synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] +is_a: GO:0002256 ! regulation of kinin cascade +relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade + +[Term] +id: GO:0002383 +name: immune response in brain or nervous system +namespace: biological_process +def: "An immune response taking place in the brain or nervous system." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002251 ! organ or tissue specific immune response + +[Term] +id: GO:0002384 +name: hepatic immune response +namespace: biological_process +def: "An immune response taking place in the liver." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002251 ! organ or tissue specific immune response + +[Term] +id: GO:0002385 +name: mucosal immune response +namespace: biological_process +def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002251 ! organ or tissue specific immune response + +[Term] +id: GO:0002386 +name: immune response in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune response in MALT" EXACT [] +is_a: GO:0002385 ! mucosal immune response + +[Term] +id: GO:0002387 +name: immune response in gut-associated lymphoid tissue +namespace: biological_process +def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune response in GALT" EXACT [] +is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002388 +name: immune response in Peyer's patch +namespace: biological_process +def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue + +[Term] +id: GO:0002389 +name: tolerance induction in Peyer's patch +namespace: biological_process +def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002388 ! immune response in Peyer's patch +is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue + +[Term] +id: GO:0002390 +name: platelet activating factor production +namespace: biological_process +def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0002391 +name: platelet activating factor production during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of platelet activating factor following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002390 ! platelet activating factor production +is_a: GO:0002534 ! cytokine production during acute inflammatory response + +[Term] +id: GO:0002392 +name: platelet activating factor secretion +namespace: biological_process +def: "The regulated release of platelet activating factor by a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0050663 ! cytokine secretion + +[Term] +id: GO:0002393 +name: production of lysosomal enzymes during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of lysosomal enzymes following a stimulus during an acute inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response + +[Term] +id: GO:0002394 +name: tolerance induction in gut-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "oral tolerance" RELATED [] +synonym: "tolerance induction in GALT" EXACT [] +is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002395 +name: immune response in nasopharyngeal-associated lymphoid tissue +namespace: biological_process +def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immune response in NALT" EXACT [] +is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002396 +name: MHC protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0002397 +name: MHC class I protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0002396 ! MHC protein complex assembly + +[Term] +id: GO:0002398 +name: MHC class Ib protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0002396 ! MHC protein complex assembly + +[Term] +id: GO:0002399 +name: MHC class II protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0002396 ! MHC protein complex assembly + +[Term] +id: GO:0002400 +name: tolerance induction in nasopharyngeal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "nasal tolerance" RELATED [] +synonym: "tolerance induction in NALT" EXACT [] +is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002401 +name: tolerance induction in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "tolerance induction in MALT" EXACT [] +is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue +is_a: GO:0002427 ! mucosal tolerance induction + +[Term] +id: GO:0002402 +name: B cell tolerance induction in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B cell tolerance induction in MALT" EXACT [] +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue +is_a: GO:0002451 ! peripheral B cell tolerance induction + +[Term] +id: GO:0002403 +name: T cell tolerance induction in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263] +synonym: "T cell tolerance induction in MALT" EXACT [] +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue +is_a: GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002404 +name: antigen sampling in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process initiating the mucosal immune response which entails the apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] +synonym: "antigen sampling in MALT" EXACT [] +synonym: "antigen transport in MALT" RELATED [] +synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002405 +name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] +synonym: "antigen sampling by dendritic cells in MALT" EXACT [] +is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue +relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002406 +name: antigen sampling by M cells in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] +synonym: "antigen sampling by M cells in MALT" EXACT [] +is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002407 +name: dendritic cell chemotaxis +namespace: biological_process +def: "The movement of a dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002408 +name: myeloid dendritic cell chemotaxis +namespace: biological_process +def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255] +is_a: GO:0002407 ! dendritic cell chemotaxis + +[Term] +id: GO:0002409 +name: Langerhans cell chemotaxis +namespace: biological_process +def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] +is_a: GO:0002408 ! myeloid dendritic cell chemotaxis + +[Term] +id: GO:0002410 +name: plasmacytoid dendritic cell chemotaxis +namespace: biological_process +def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] +is_a: GO:0002407 ! dendritic cell chemotaxis + +[Term] +id: GO:0002411 +name: T cell tolerance induction to tumor cell +namespace: biological_process +def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002413 ! tolerance induction to tumor cell +is_a: GO:0002424 ! T cell mediated immune response to tumor cell +is_a: GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002412 +name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:12843411] +synonym: "antigen transcytosis by M cells in MALT" EXACT [] +synonym: "antigen transport by M cells in MALT" EXACT [] +synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] +is_a: GO:0045056 ! transcytosis +relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002413 +name: tolerance induction to tumor cell +namespace: biological_process +def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] +is_a: GO:0002418 ! immune response to tumor cell +is_a: GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002414 +name: immunoglobulin transcytosis in epithelial cells +namespace: biological_process +def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543] +is_a: GO:0045056 ! transcytosis + +[Term] +id: GO:0002415 +name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor +namespace: biological_process +def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543] +synonym: "antibody transcytosis mediated by pIgR" EXACT [] +synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] +is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells +relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002416 +name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor +namespace: biological_process +def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X] +synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] +synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] +is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells + +[Term] +id: GO:0002417 +name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen +namespace: biological_process +def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] +synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] +synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] +is_a: GO:0002450 ! B cell antigen processing and presentation +is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis + +[Term] +id: GO:0002418 +name: immune response to tumor cell +namespace: biological_process +def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002419 +name: T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. +synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0001913 ! T cell mediated cytotoxicity +is_a: GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002420 +name: natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. +synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell +is_a: GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0002421 +name: B cell antigen processing and presentation following pinocytosis +namespace: biological_process +def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] +synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] +synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] +synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] +is_a: GO:0002450 ! B cell antigen processing and presentation +is_a: GO:0002746 ! antigen processing and presentation following pinocytosis + +[Term] +id: GO:0002422 +name: immune response in urogenital tract +namespace: biological_process +def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal] +is_a: GO:0002385 ! mucosal immune response + +[Term] +id: GO:0002423 +name: natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +is_a: GO:0002228 ! natural killer cell mediated immunity +is_a: GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002424 +name: T cell mediated immune response to tumor cell +namespace: biological_process +def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] +comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. +is_a: GO:0002418 ! immune response to tumor cell +is_a: GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002425 +name: tolerance induction in urogenital tract +namespace: biological_process +def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] +is_a: GO:0002422 ! immune response in urogenital tract +is_a: GO:0002427 ! mucosal tolerance induction + +[Term] +id: GO:0002426 +name: immunoglobulin production in mucosal tissue +namespace: biological_process +def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] +synonym: "antibody production in mucosal tissue " EXACT [] +is_a: GO:0002381 ! immunoglobulin production during immune response +relationship: part_of GO:0002385 ! mucosal immune response + +[Term] +id: GO:0002427 +name: mucosal tolerance induction +namespace: biological_process +def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] +is_a: GO:0002385 ! mucosal immune response +is_a: GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002428 +name: antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] +synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002429 +name: immune response-activating cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] +synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002757 ! immune response-activating signal transduction +is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway + +[Term] +id: GO:0002430 +name: complement receptor mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "complement receptor mediated signalling pathway" EXACT [] +synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway + +[Term] +id: GO:0002431 +name: Fc receptor mediated stimulatory signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] +synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway + +[Term] +id: GO:0002432 +name: granuloma formation +namespace: biological_process +def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0721601464, ISBN:081533642X] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002252 ! immune effector process +relationship: part_of GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002433 +name: phagocytosis triggered by activation of immune response cell surface activating receptor +namespace: biological_process +def: "Phagocytosis occurring as the result of a ligand binding an immune response cell surface activating receptor." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002252 ! immune effector process +is_a: GO:0006909 ! phagocytosis + +[Term] +id: GO:0002434 +name: immune complex clearance +namespace: biological_process +def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0002435 +name: immune complex clearance by erythrocytes +namespace: biological_process +def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352] +synonym: "immune complex clearance by red blood cells" EXACT [] +is_a: GO:0002434 ! immune complex clearance + +[Term] +id: GO:0002436 +name: immune complex clearance by monocytes and macrophages +namespace: biological_process +def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002434 ! immune complex clearance + +[Term] +id: GO:0002437 +name: inflammatory response to antigenic stimulus +namespace: biological_process +def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0006954 ! inflammatory response +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002438 +name: acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002437 ! inflammatory response to antigenic stimulus +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002439 +name: chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002437 ! inflammatory response to antigenic stimulus +is_a: GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002440 +name: production of molecular mediator of immune response +namespace: biological_process +def: "The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "production of cellular mediator of immune response" RELATED [] +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0002441 +name: histamine secretion during acute inflammatory response +namespace: biological_process +def: "The regulated release of histamine by a cell or group of cells during an acute inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001821 ! histamine secretion +is_a: GO:0046879 ! hormone secretion +relationship: part_of GO:0002349 ! histamine production during acute inflammatory response + +[Term] +id: GO:0002442 +name: serotonin secretion during acute inflammatory response +namespace: biological_process +def: "The regulated release of serotonin by a cell or group of cells during an acute inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001820 ! serotonin secretion +relationship: part_of GO:0002351 ! serotonin production during acute inflammatory response + +[Term] +id: GO:0002443 +name: leukocyte mediated immunity +namespace: biological_process +alt_id: GO:0019723 +alt_id: GO:0042087 +def: "Any process involved in the carrying out of an immune response by a leukocyte." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "cell-mediated immune response" RELATED [] +synonym: "cellular immune response" RELATED [] +synonym: "immune cell effector process" EXACT [] +synonym: "immune cell mediated immunity" EXACT [] +synonym: "leucocyte immune effector process" EXACT [] +synonym: "leucocyte mediated immunity" EXACT [] +synonym: "leukocyte immune effector process" EXACT [] +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0002444 +name: myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "myeloid leucocyte immune effector process" EXACT [] +synonym: "myeloid leucocyte mediated immunity" EXACT [] +synonym: "myeloid leukocyte immune effector process" EXACT [] +is_a: GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002445 +name: type II hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002444 ! myeloid leukocyte mediated immunity +is_a: GO:0002524 ! hypersensitivity +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002446 +name: neutrophil mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a neutrophil." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002447 +name: eosinophil mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by an eosinophil." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002448 +name: mast cell mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a mast cell." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002449 +name: lymphocyte mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "cell-mediated immunity" BROAD [] +synonym: "cellular immune response" BROAD [] +is_a: GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002450 +name: B cell antigen processing and presentation +namespace: biological_process +def: "The process by which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "B lymphocyte antigen processing and presentation" EXACT [] +synonym: "B-cell antigen processing and presentation" EXACT [] +synonym: "B-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation +relationship: part_of GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002451 +name: peripheral B cell tolerance induction +namespace: biological_process +def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "peripheral B lymphocyte tolerance induction" EXACT [] +synonym: "peripheral B-cell tolerance induction" EXACT [] +synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002465 ! peripheral tolerance induction +is_a: GO:0002514 ! B cell tolerance induction +is_a: GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002452 +name: B cell receptor editing +namespace: biological_process +def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B lymphocyte receptor editing" EXACT [] +synonym: "B-cell receptor editing" EXACT [] +synonym: "B-lymphocyte receptor editing" EXACT [] +is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments + +[Term] +id: GO:0002453 +name: peripheral B cell anergy +namespace: biological_process +def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "peripheral B lymphocyte anergy" EXACT [] +synonym: "peripheral B-cell anergy" EXACT [] +synonym: "peripheral B-lymphocyte anergy" EXACT [] +is_a: GO:0002515 ! B cell anergy +relationship: part_of GO:0002451 ! peripheral B cell tolerance induction + +[Term] +id: GO:0002454 +name: peripheral B cell deletion +namespace: biological_process +def: "The deletion of B cells by apoptosis occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "peripheral B lymphocyte deletion" EXACT [] +synonym: "peripheral B-cell deletion" EXACT [] +synonym: "peripheral B-lymphocyte deletion" EXACT [] +is_a: GO:0002516 ! B cell deletion +relationship: part_of GO:0002451 ! peripheral B cell tolerance induction + +[Term] +id: GO:0002455 +name: humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "An immune response dependent upon secreted immunoglobulin." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "circulating antibody mediated immune response" EXACT [] +synonym: "circulating immunoglobulin mediated immune response" EXACT [] +synonym: "humoral defence mechanism (sensu Vertebrata)" RELATED [] +synonym: "humoral defense mechanism (sensu Vertebrata)" RELATED [] +synonym: "humoral immune response mediated by circulating antibody" EXACT [] +is_a: GO:0006959 ! humoral immune response +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002456 +name: T cell mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a T cell." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "cell-mediated immunity" BROAD [] +synonym: "cellular immune response" BROAD [] +synonym: "T lymphocyte mediated immunity" EXACT [] +synonym: "T-cell mediated immunity" EXACT [] +synonym: "T-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002449 ! lymphocyte mediated immunity +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002457 +name: T cell antigen processing and presentation +namespace: biological_process +def: "The process by which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] +synonym: "T lymphocyte antigen processing and presentation" EXACT [] +synonym: "T-cell antigen processing and presentation" EXACT [] +synonym: "T-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation +relationship: part_of GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002458 +name: peripheral T cell tolerance induction +namespace: biological_process +def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "peripheral T lymphocyte tolerance induction" EXACT [] +synonym: "peripheral T-cell tolerance induction" EXACT [] +synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002456 ! T cell mediated immunity +is_a: GO:0002465 ! peripheral tolerance induction +is_a: GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002459 +name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains +namespace: biological_process +def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:mtg_sensu, PMID:16373579] +synonym: "adaptive immune response (sensu Myxinidae and Petromyzontidae)" RELATED [] +synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] +synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] +synonym: "adaptive immune response in jawless fish" EXACT [] +is_a: GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002460 +name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies)." [GOC:add, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology"] +synonym: "adaptive immune response (sensu Gnathostomata)" EXACT [] +is_a: GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002461 +name: tolerance induction dependent upon immune response +namespace: biological_process +def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +synonym: "immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002462 +name: tolerance induction to nonself antigen +namespace: biological_process +def: "Tolerance induction in response to nonself antigens." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002463 +name: central tolerance induction to nonself antigen +namespace: biological_process +def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] +is_a: GO:0002462 ! tolerance induction to nonself antigen +is_a: GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002464 +name: peripheral tolerance induction to nonself antigen +namespace: biological_process +def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002462 ! tolerance induction to nonself antigen +is_a: GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002465 +name: peripheral tolerance induction +namespace: biological_process +def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002466 +name: peripheral tolerance induction to self antigen +namespace: biological_process +def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002465 ! peripheral tolerance induction +is_a: GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002467 +name: germinal center formation +namespace: biological_process +def: "The process by which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GOC:jal, GOC:mtg_15nov05, ISBN:081533642X] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002468 +name: dendritic cell antigen processing and presentation +namespace: biological_process +def: "The process by which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002469 +name: myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "The process by which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002470 +name: plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "The process by which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002471 +name: monocyte antigen processing and presentation +namespace: biological_process +def: "The process by which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002472 +name: macrophage antigen processing and presentation +namespace: biological_process +def: "The process by which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002473 +name: non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "The process by which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002474 +name: antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] +synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002475 +name: antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002476 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib +is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen + +[Term] +id: GO:0002477 +name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib +is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen + +[Term] +id: GO:0002478 +name: antigen processing and presentation of exogenous peptide antigen +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "exogenous peptide antigen processing and presentation" EXACT [] +is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002479 +name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] +synonym: "cross presentation" BROAD [] +synonym: "cross-presentation" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] +synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I + +[Term] +id: GO:0002480 +name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] +synonym: "cross presentation" BROAD [] +synonym: "cross-presentation" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] +synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I + +[Term] +id: GO:0002481 +name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] +synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib + +[Term] +id: GO:0002482 +name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] +synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib + +[Term] +id: GO:0002483 +name: antigen processing and presentation of endogenous peptide antigen +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "endogenous peptide antigen processing and presentation" EXACT [] +is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002484 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] +is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:0002485 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] +synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] +is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway + +[Term] +id: GO:0002486 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] +synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] +is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway + +[Term] +id: GO:0002487 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] +is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:0002488 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] +is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib + +[Term] +id: GO:0002489 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] +synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] +is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway + +[Term] +id: GO:0002490 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] +synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] +is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway + +[Term] +id: GO:0002491 +name: antigen processing and presentation of endogenous peptide antigen via MHC class II +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] +synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen +is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002492 +name: peptide antigen assembly with MHC class Ib protein complex +namespace: biological_process +def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex +relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly +relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002493 +name: lipid antigen assembly with MHC class Ib protein complex +namespace: biological_process +def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0065005 ! protein-lipid complex assembly +relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly +relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002494 +name: lipid antigen transport +namespace: biological_process +def: "The directed movement of a lipid antigen into, out of, within or between cells." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0006869 ! lipid transport +relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002495 +name: antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591] +synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002496 +name: proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002497 +name: proteasomal proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation +is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0002498 +name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] +synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002499 +name: proteolysis within endosome associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002500 +name: proteolysis within lysosome associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation +is_a: GO:0007039 ! vacuolar protein catabolic process + +[Term] +id: GO:0002501 +name: peptide antigen assembly with MHC protein complex +namespace: biological_process +def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0002396 ! MHC protein complex assembly +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002502 +name: peptide antigen assembly with MHC class I protein complex +namespace: biological_process +def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex +relationship: part_of GO:0002397 ! MHC class I protein complex assembly +relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002503 +name: peptide antigen assembly with MHC class II protein complex +namespace: biological_process +def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex +relationship: part_of GO:0002399 ! MHC class II protein complex assembly +relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002504 +name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591, PMID:16153240] +synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002505 +name: antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] +synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002506 +name: polysaccharide assembly with MHC class II protein complex +namespace: biological_process +def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240] +is_a: GO:0065006 ! protein-carbohydrate complex assembly +relationship: part_of GO:0002399 ! MHC class II protein complex assembly +relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002507 +name: tolerance induction +namespace: biological_process +def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002376 ! immune system process + +[Term] +id: GO:0002508 +name: central tolerance induction +namespace: biological_process +def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002507 ! tolerance induction +relationship: part_of GO:0002520 ! immune system development + +[Term] +id: GO:0002509 +name: central tolerance induction to self antigen +namespace: biological_process +def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922] +is_a: GO:0002508 ! central tolerance induction +is_a: GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002510 +name: central B cell tolerance induction +namespace: biological_process +def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] +synonym: "central B lymphocyte tolerance induction" EXACT [] +synonym: "central B-cell tolerance induction" EXACT [] +synonym: "central B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002508 ! central tolerance induction +is_a: GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002511 +name: central B cell receptor editing +namespace: biological_process +def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] +synonym: "central B lymphocyte receptor editing" EXACT [] +synonym: "central B-cell receptor editing" EXACT [] +synonym: "central B-lymphocyte receptor editing" EXACT [] +is_a: GO:0002452 ! B cell receptor editing + +[Term] +id: GO:0002512 +name: central T cell tolerance induction +namespace: biological_process +def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "central T lymphocyte tolerance induction" EXACT [] +synonym: "central T-cell tolerance induction" EXACT [] +synonym: "central T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002508 ! central tolerance induction +is_a: GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002513 +name: tolerance induction to self antigen +namespace: biological_process +def: "Tolerance induction directed at self antigens." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002514 +name: B cell tolerance induction +namespace: biological_process +def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922] +synonym: "B lymphocyte tolerance induction" EXACT [] +synonym: "B-cell tolerance induction" EXACT [] +synonym: "B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002515 +name: B cell anergy +namespace: biological_process +def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B lymphocyte anergy" EXACT [] +synonym: "B-cell anergy" EXACT [] +synonym: "B-lymphocyte anergy" EXACT [] +is_a: GO:0002249 ! lymphocyte anergy +is_a: GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002516 +name: B cell deletion +namespace: biological_process +def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "B lymphocyte deletion" EXACT [] +synonym: "B-cell deletion" EXACT [] +synonym: "B-lymphocyte deletion" EXACT [] +is_a: GO:0001783 ! B cell apoptosis +relationship: part_of GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002517 +name: T cell tolerance induction +namespace: biological_process +def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263] +synonym: "T lymphocyte tolerance induction" EXACT [] +synonym: "T-cell tolerance induction" EXACT [] +synonym: "T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002518 +name: lymphocyte chemotaxis across high endothelial venule +namespace: biological_process +def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15122201] +is_a: GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:0002519 +name: natural killer cell tolerance induction +namespace: biological_process +def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] +synonym: "NK cell tolerance induction" EXACT [] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002520 +name: immune system development +namespace: biological_process +def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] +is_a: GO:0002376 ! immune system process +is_a: GO:0048731 ! system development + +[Term] +id: GO:0002521 +name: leukocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages." [GOC:add, PMID:16551264] +synonym: "immune cell differentiation" EXACT [] +synonym: "leucocyte differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0002522 +name: leukocyte migration during immune response +namespace: biological_process +def: "The movement of leukocytes within or between different tissues and organs of the body during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "immune cell migration during immune response" EXACT [] +synonym: "immune cell trafficking during immune response" EXACT [] +synonym: "leucocyte migration during immune response" EXACT [] +synonym: "leucocyte trafficking during immune response" EXACT [] +synonym: "leukocyte trafficking during immune response" EXACT [] +is_a: GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002523 +name: leukocyte migration during inflammatory response +namespace: biological_process +def: "The movement of leukocytes within or between different tissues and organs of the body during an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "immune cell migration during inflammatory response" EXACT [] +synonym: "immune cell trafficking during inflammatory response" EXACT [] +synonym: "leucocyte migration during inflammatory response" EXACT [] +synonym: "leucocyte trafficking during inflammatory response" EXACT [] +synonym: "leukocyte trafficking during inflammatory response" EXACT [] +is_a: GO:0050900 ! leukocyte migration +relationship: part_of GO:0006954 ! inflammatory response + +[Term] +id: GO:0002524 +name: hypersensitivity +namespace: biological_process +def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "hypersensitivity response" RELATED [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002525 +name: acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002526 +name: acute inflammatory response +namespace: biological_process +def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0006954 ! inflammatory response + +[Term] +id: GO:0002527 +name: vasodilation during acute inflammatory response +namespace: biological_process +def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure during an acute inflammatory response." [GOC:jal] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002528 +name: regulation of vascular permeability during acute inflammatory response +namespace: biological_process +def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid during an acute inflammatory response." [GOC:jal] +is_a: GO:0043114 ! regulation of vascular permeability +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002529 +name: regulation of plasma kallikrein-kinin cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] +is_a: GO:0002256 ! regulation of kinin cascade +relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002530 +name: regulation of systemic arterial blood pressure during acute phase response +namespace: biological_process +def: "Any process that modulates the force with which blood travels through the circulatory system during the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] +synonym: "blood pressure regulation during acute phase response" EXACT [] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure +relationship: part_of GO:0006953 ! acute-phase response + +[Term] +id: GO:0002531 +name: regulation of heart contraction during acute phase response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heart contraction during the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] +synonym: "regulation of cardiac contraction during acute phase response" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +relationship: part_of GO:0006953 ! acute-phase response + +[Term] +id: GO:0002532 +name: production of molecular mediator of acute inflammatory response +namespace: biological_process +def: "The synthesis or release of any molecular mediator of the acute inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "production of cellular mediator of acute inflammation" RELATED [] +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002533 +name: secretion of lysosomal enzymes during acute inflammatory response +namespace: biological_process +def: "The regulated release of lysosomal enzymes by a cell or group of cells during an acute inflammatory response." [GOC:jal, PMID:11836514] +is_a: GO:0033299 ! secretion of lysosomal enzymes +relationship: part_of GO:0002393 ! production of lysosomal enzymes during acute inflammatory response + +[Term] +id: GO:0002534 +name: cytokine production during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of a cytokine following a inflammatory stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001816 ! cytokine production +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response + +[Term] +id: GO:0002535 +name: platelet activating factor secretion during acute inflammatory response +namespace: biological_process +def: "The regulated release of platelet activating factor by a cell or group of cells during an acute inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002392 ! platelet activating factor secretion +relationship: part_of GO:0002391 ! platelet activating factor production during acute inflammatory response + +[Term] +id: GO:0002536 +name: respiratory burst during acute inflammatory response +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus during an acute inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "oxidative burst during acute inflammatory response " EXACT [] +synonym: "production of reactive oxygen species during acute inflammatory response" EXACT [] +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response +is_a: GO:0002679 ! respiratory burst during defense response + +[Term] +id: GO:0002537 +name: production of nitric oxide during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of nitric oxide following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response + +[Term] +id: GO:0002538 +name: production of arachidonic acid metabolites during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus during an acute inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response + +[Term] +id: GO:0002539 +name: prostaglandin production during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of any prostaglandin following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002538 ! production of arachidonic acid metabolites during acute inflammatory response + +[Term] +id: GO:0002540 +name: leukotriene production during acute inflammatory response +namespace: biological_process +def: "The synthesis or release of any leukotriene following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002538 ! production of arachidonic acid metabolites during acute inflammatory response + +[Term] +id: GO:0002541 +name: activation of plasma proteins during acute inflammatory response +namespace: biological_process +def: "Any process activating plasma proteins via proteolysis during an acute inflammatory response." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0006508 ! proteolysis +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002542 +name: Factor XII activation +namespace: biological_process +def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] +synonym: "Hageman factor activation" EXACT [] +is_a: GO:0002541 ! activation of plasma proteins during acute inflammatory response +relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002543 +name: activation of blood coagulation via clotting cascade +namespace: biological_process +def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of clotting cascade" EXACT [] +is_a: GO:0030194 ! positive regulation of blood coagulation +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002544 +name: chronic inflammatory response +namespace: biological_process +def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was added by GO_REF:0000022. +is_a: GO:0006954 ! inflammatory response + +[Term] +id: GO:0002545 +name: chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] +is_a: GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002546 +name: negative regulation of tissue kallikrein-kinin cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] +synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] +synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] +is_a: GO:0002257 ! negative regulation of kinin cascade +is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade +relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade + +[Term] +id: GO:0002547 +name: positive regulation of tissue kallikrein-kinin cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] +synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] +synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] +synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] +synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] +is_a: GO:0002258 ! positive regulation of kinin cascade +is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade +relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade + +[Term] +id: GO:0002548 +name: monocyte chemotaxis +namespace: biological_process +def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002549 +name: negative regulation of plasma kallikrein-kinin cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] +synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] +is_a: GO:0002257 ! negative regulation of kinin cascade +is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade +relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002550 +name: positive regulation of plasma kallikrein-kinin cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] +synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] +synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] +synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] +is_a: GO:0002258 ! positive regulation of kinin cascade +is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade +relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002551 +name: mast cell chemotaxis +namespace: biological_process +def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002552 +name: serotonin secretion by mast cell +namespace: biological_process +def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002442 ! serotonin secretion during acute inflammatory response +relationship: part_of GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0002553 +name: histamine secretion by mast cell +namespace: biological_process +def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002441 ! histamine secretion during acute inflammatory response +relationship: part_of GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0002554 +name: serotonin secretion by platelet +namespace: biological_process +def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002442 ! serotonin secretion during acute inflammatory response +relationship: part_of GO:0002576 ! platelet degranulation + +[Term] +id: GO:0002555 +name: histamine secretion by platelet +namespace: biological_process +def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] +is_a: GO:0002441 ! histamine secretion during acute inflammatory response +relationship: part_of GO:0002576 ! platelet degranulation + +[Term] +id: GO:0002556 +name: serotonin secretion by basophil +namespace: biological_process +def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002442 ! serotonin secretion during acute inflammatory response +relationship: part_of GO:0002561 ! basophil degranulation + +[Term] +id: GO:0002557 +name: histamine secretion by basophil +namespace: biological_process +def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002441 ! histamine secretion during acute inflammatory response +relationship: part_of GO:0002561 ! basophil degranulation + +[Term] +id: GO:0002558 +name: type I hypersensitivity mediated by mast cells +namespace: biological_process +def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002448 ! mast cell mediated immunity +is_a: GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0002559 +name: type I hypersensitivity mediated by basophils +namespace: biological_process +def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002560 ! basophil mediated immunity +is_a: GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0002560 +name: basophil mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002561 +name: basophil degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0043299 ! leukocyte degranulation +is_a: GO:0045575 ! basophil activation +relationship: part_of GO:0002560 ! basophil mediated immunity + +[Term] +id: GO:0002562 +name: somatic diversification of immune receptors via germline recombination within a single locus +namespace: biological_process +def: "The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509] +is_a: GO:0002200 ! somatic diversification of immune receptors +is_a: GO:0016444 ! somatic cell DNA recombination + +[Term] +id: GO:0002563 +name: somatic diversification of immune receptors via alternate splicing +namespace: biological_process +def: "The process by which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16166509] +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002564 +name: alternate splicing of immunoglobulin genes +namespace: biological_process +def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149 "Fundamental Immunology", PMID:9185563] +synonym: "alternate splicing of antibody genes" EXACT [] +is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0002565 +name: somatic diversification of immune receptors via gene conversion +namespace: biological_process +def: "The process by which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002200 ! somatic diversification of immune receptors +is_a: GO:0016444 ! somatic cell DNA recombination + +[Term] +id: GO:0002566 +name: somatic diversification of immune receptors via somatic mutation +namespace: biological_process +def: "The process by which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149 "Fundamental Immunology", PMID:16102575] +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002567 +name: somatic diversification of FREP-based immune receptors +namespace: biological_process +def: "The process by means of which sequence diversity of the FREP-based immune receptors of snails is generated." [GOC:add, PMID:16102575] +comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002568 +name: somatic diversification of T cell receptor genes +namespace: biological_process +def: "The somatic process by means of which sequence diversity of T cell receptor genes is generated." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic diversification of TCR genes" EXACT [] +is_a: GO:0002200 ! somatic diversification of immune receptors +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002569 +name: somatic diversification of immune receptors by N region addition +namespace: biological_process +def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002570 +name: somatic diversification of immunoglobulin genes by N region addition +namespace: biological_process +def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic diversification of antibody genes by N region addition" EXACT [] +is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition +is_a: GO:0016445 ! somatic diversification of immunoglobulins +relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments + +[Term] +id: GO:0002571 +name: somatic diversification of T cell receptor genes by N region addition +namespace: biological_process +def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic diversification of TCR genes by N region addition" EXACT [] +is_a: GO:0002568 ! somatic diversification of T cell receptor genes +is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition +relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments + +[Term] +id: GO:0002572 +name: pro-T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "pro-T lymphocyte differentiation " EXACT [] +is_a: GO:0002320 ! lymphoid progenitor cell differentiation +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002573 +name: myeloid leukocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] +synonym: "myeloid leucocyte differentiation" EXACT [] +is_a: GO:0002521 ! leukocyte differentiation +is_a: GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0002574 +name: thrombocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] +comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. +is_a: GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0002575 +name: basophil chemotaxis +namespace: biological_process +def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002576 +name: platelet degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] +synonym: "platelet exocytosis" EXACT [] +is_a: GO:0006887 ! exocytosis + +[Term] +id: GO:0002577 +name: regulation of antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +relationship: regulates GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002578 +name: negative regulation of antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] +synonym: "down regulation of antigen processing and presentation" EXACT [] +synonym: "down-regulation of antigen processing and presentation" EXACT [] +synonym: "downregulation of antigen processing and presentation" EXACT [] +synonym: "inhibition of antigen processing and presentation" NARROW [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002683 ! negative regulation of immune system process +relationship: negatively_regulates GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002579 +name: positive regulation of antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] +synonym: "activation of antigen processing and presentation" NARROW [] +synonym: "stimulation of antigen processing and presentation" NARROW [] +synonym: "up regulation of antigen processing and presentation" EXACT [] +synonym: "up-regulation of antigen processing and presentation" EXACT [] +synonym: "upregulation of antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002684 ! positive regulation of immune system process +relationship: positively_regulates GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002580 +name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] +synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002581 +name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] +synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002582 +name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] +synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002583 +name: regulation of antigen processing and presentation of peptide antigen +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002584 +name: negative regulation of antigen processing and presentation of peptide antigen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002585 +name: positive regulation of antigen processing and presentation of peptide antigen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002586 +name: regulation of antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002587 +name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II +relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002588 +name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II +relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002589 +name: regulation of antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002590 +name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I +relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002591 +name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I +relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002592 +name: regulation of antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0002593 +name: negative regulation of antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] +synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0002594 +name: positive regulation of antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] +synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] +synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] +synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0002595 +name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002596 +name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib +relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002597 +name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib +relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002598 +name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] +synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002599 +name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] +synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] +synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib +relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002600 +name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] +synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] +synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] +synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib +relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002601 +name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] +synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002602 +name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] +synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] +synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002603 +name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] +synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] +synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] +synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] +synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002604 +name: regulation of dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002605 +name: negative regulation of dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002606 +name: positive regulation of dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] +synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] +synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] +synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002607 +name: regulation of myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002608 +name: negative regulation of myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] +is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation +is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation +relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002609 +name: positive regulation of myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] +synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] +synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation +is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation +relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002610 +name: regulation of plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002611 +name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] +is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation +is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation +relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002612 +name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] +synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] +synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation +is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation +relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002613 +name: regulation of monocyte antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002471 ! monocyte antigen processing and presentation + +[Term] +id: GO:0002614 +name: negative regulation of monocyte antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] +synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] +synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation +relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation + +[Term] +id: GO:0002615 +name: positive regulation of monocyte antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] +synonym: "activation of monocyte antigen processing and presentation" NARROW [] +synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] +synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation +relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation + +[Term] +id: GO:0002616 +name: regulation of macrophage antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002472 ! macrophage antigen processing and presentation + +[Term] +id: GO:0002617 +name: negative regulation of macrophage antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] +synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] +synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation +relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation + +[Term] +id: GO:0002618 +name: positive regulation of macrophage antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] +synonym: "activation of macrophage antigen processing and presentation" NARROW [] +synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] +synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation +relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation + +[Term] +id: GO:0002619 +name: regulation of non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation + +[Term] +id: GO:0002620 +name: negative regulation of non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation +relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation + +[Term] +id: GO:0002621 +name: positive regulation of non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] +synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] +synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] +synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation +relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation + +[Term] +id: GO:0002622 +name: regulation of B cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] +synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] +synonym: "regulation of B-cell antigen processing and presentation" EXACT [] +synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002712 ! regulation of B cell mediated immunity +relationship: regulates GO:0002450 ! B cell antigen processing and presentation + +[Term] +id: GO:0002623 +name: negative regulation of B cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of B cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] +synonym: "downregulation of B cell antigen processing and presentation" EXACT [] +synonym: "inhibition of B cell antigen processing and presentation" NARROW [] +synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] +synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] +synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002622 ! regulation of B cell antigen processing and presentation +relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation + +[Term] +id: GO:0002624 +name: positive regulation of B cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] +synonym: "activation of B cell antigen processing and presentation" NARROW [] +synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] +synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] +synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] +synonym: "stimulation of B cell antigen processing and presentation" NARROW [] +synonym: "up regulation of B cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] +synonym: "upregulation of B cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002622 ! regulation of B cell antigen processing and presentation +relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation + +[Term] +id: GO:0002625 +name: regulation of T cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] +synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] +synonym: "regulation of T-cell antigen processing and presentation" EXACT [] +synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002709 ! regulation of T cell mediated immunity +relationship: regulates GO:0002457 ! T cell antigen processing and presentation + +[Term] +id: GO:0002626 +name: negative regulation of T cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of T cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] +synonym: "downregulation of T cell antigen processing and presentation" EXACT [] +synonym: "inhibition of T cell antigen processing and presentation" NARROW [] +synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] +synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] +synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002625 ! regulation of T cell antigen processing and presentation +relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation + +[Term] +id: GO:0002627 +name: positive regulation of T cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] +synonym: "activation of T cell antigen processing and presentation" NARROW [] +synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] +synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] +synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] +synonym: "stimulation of T cell antigen processing and presentation" NARROW [] +synonym: "up regulation of T cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] +synonym: "upregulation of T cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002625 ! regulation of T cell antigen processing and presentation +relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation + +[Term] +id: GO:0002628 +name: regulation of proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002629 +name: negative regulation of proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] +synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] +is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:0045861 ! negative regulation of proteolysis +relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002630 +name: positive regulation of proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] +synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] +synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] +synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] +is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:0045862 ! positive regulation of proteolysis +relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002631 +name: regulation of granuloma formation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0002697 ! regulation of immune effector process +relationship: regulates GO:0002432 ! granuloma formation + +[Term] +id: GO:0002632 +name: negative regulation of granuloma formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] +synonym: "down regulation of granuloma formation" EXACT [] +synonym: "down-regulation of granuloma formation" EXACT [] +synonym: "downregulation of granuloma formation" EXACT [] +synonym: "inhibition of granuloma formation" NARROW [] +is_a: GO:0002631 ! regulation of granuloma formation +is_a: GO:0002698 ! negative regulation of immune effector process +relationship: negatively_regulates GO:0002432 ! granuloma formation + +[Term] +id: GO:0002633 +name: positive regulation of granuloma formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] +synonym: "activation of granuloma formation" NARROW [] +synonym: "stimulation of granuloma formation" NARROW [] +synonym: "up regulation of granuloma formation" EXACT [] +synonym: "up-regulation of granuloma formation" EXACT [] +synonym: "upregulation of granuloma formation" EXACT [] +is_a: GO:0002631 ! regulation of granuloma formation +is_a: GO:0002699 ! positive regulation of immune effector process +relationship: positively_regulates GO:0002432 ! granuloma formation + +[Term] +id: GO:0002634 +name: regulation of germinal center formation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0002467 ! germinal center formation + +[Term] +id: GO:0002635 +name: negative regulation of germinal center formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] +synonym: "down regulation of germinal center formation" EXACT [] +synonym: "down-regulation of germinal center formation" EXACT [] +synonym: "downregulation of germinal center formation" EXACT [] +synonym: "inhibition of germinal center formation" NARROW [] +is_a: GO:0002634 ! regulation of germinal center formation +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002467 ! germinal center formation + +[Term] +id: GO:0002636 +name: positive regulation of germinal center formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] +synonym: "activation of germinal center formation" NARROW [] +synonym: "stimulation of germinal center formation" NARROW [] +synonym: "up regulation of germinal center formation" EXACT [] +synonym: "up-regulation of germinal center formation" EXACT [] +synonym: "upregulation of germinal center formation" EXACT [] +is_a: GO:0002634 ! regulation of germinal center formation +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002467 ! germinal center formation + +[Term] +id: GO:0002637 +name: regulation of immunoglobulin production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: regulates GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002638 +name: negative regulation of immunoglobulin production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] +synonym: "down regulation of immunoglobulin production" EXACT [] +synonym: "down-regulation of immunoglobulin production" EXACT [] +synonym: "downregulation of immunoglobulin production" EXACT [] +synonym: "inhibition of immunoglobulin production" NARROW [] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +relationship: negatively_regulates GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002639 +name: positive regulation of immunoglobulin production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] +synonym: "activation of immunoglobulin production" NARROW [] +synonym: "stimulation of immunoglobulin production" NARROW [] +synonym: "up regulation of immunoglobulin production" EXACT [] +synonym: "up-regulation of immunoglobulin production" EXACT [] +synonym: "upregulation of immunoglobulin production" EXACT [] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +relationship: positively_regulates GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002640 +name: regulation of immunoglobulin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process + +[Term] +id: GO:0002641 +name: negative regulation of immunoglobulin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] +synonym: "down regulation of immunoglobulin biosynthetic process" EXACT [] +synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT [] +synonym: "downregulation of immunoglobulin biosynthetic process" EXACT [] +synonym: "inhibition of immunoglobulin biosynthetic process" NARROW [] +is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process + +[Term] +id: GO:0002642 +name: positive regulation of immunoglobulin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] +synonym: "activation of immunoglobulin biosynthetic process" NARROW [] +synonym: "stimulation of immunoglobulin biosynthetic process" NARROW [] +synonym: "up regulation of immunoglobulin biosynthetic process" EXACT [] +synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT [] +synonym: "upregulation of immunoglobulin biosynthetic process" EXACT [] +is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process + +[Term] +id: GO:0002643 +name: regulation of tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +relationship: regulates GO:0002507 ! tolerance induction + +[Term] +id: GO:0002644 +name: negative regulation of tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] +synonym: "down regulation of tolerance induction" EXACT [] +synonym: "down-regulation of tolerance induction" EXACT [] +synonym: "downregulation of tolerance induction" EXACT [] +synonym: "inhibition of tolerance induction" NARROW [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002683 ! negative regulation of immune system process +relationship: negatively_regulates GO:0002507 ! tolerance induction + +[Term] +id: GO:0002645 +name: positive regulation of tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] +synonym: "activation of tolerance induction" NARROW [] +synonym: "stimulation of tolerance induction" NARROW [] +synonym: "up regulation of tolerance induction" EXACT [] +synonym: "up-regulation of tolerance induction" EXACT [] +synonym: "upregulation of tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002684 ! positive regulation of immune system process +relationship: positively_regulates GO:0002507 ! tolerance induction + +[Term] +id: GO:0002646 +name: regulation of central tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002647 +name: negative regulation of central tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] +synonym: "down regulation of central tolerance induction" EXACT [] +synonym: "down-regulation of central tolerance induction" EXACT [] +synonym: "downregulation of central tolerance induction" EXACT [] +synonym: "inhibition of central tolerance induction" NARROW [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002646 ! regulation of central tolerance induction +relationship: negatively_regulates GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002648 +name: positive regulation of central tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] +synonym: "activation of central tolerance induction" NARROW [] +synonym: "stimulation of central tolerance induction" NARROW [] +synonym: "up regulation of central tolerance induction" EXACT [] +synonym: "up-regulation of central tolerance induction" EXACT [] +synonym: "upregulation of central tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002646 ! regulation of central tolerance induction +relationship: positively_regulates GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002649 +name: regulation of tolerance induction to self antigen +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002650 +name: negative regulation of tolerance induction to self antigen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] +synonym: "down regulation of tolerance induction to self antigen" EXACT [] +synonym: "down-regulation of tolerance induction to self antigen" EXACT [] +synonym: "downregulation of tolerance induction to self antigen" EXACT [] +synonym: "inhibition of tolerance induction to self antigen" NARROW [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002649 ! regulation of tolerance induction to self antigen +relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002651 +name: positive regulation of tolerance induction to self antigen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] +synonym: "activation of tolerance induction to self antigen" NARROW [] +synonym: "stimulation of tolerance induction to self antigen" NARROW [] +synonym: "up regulation of tolerance induction to self antigen" EXACT [] +synonym: "up-regulation of tolerance induction to self antigen" EXACT [] +synonym: "upregulation of tolerance induction to self antigen" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002649 ! regulation of tolerance induction to self antigen +relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002652 +name: regulation of tolerance induction dependent upon immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] +synonym: "regulation of immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002653 +name: negative regulation of tolerance induction dependent upon immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] +synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] +synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002654 +name: positive regulation of tolerance induction dependent upon immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] +synonym: "activation of tolerance induction dependent upon immune response" NARROW [] +synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] +synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] +synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002655 +name: regulation of tolerance induction to nonself antigen +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +relationship: regulates GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002656 +name: negative regulation of tolerance induction to nonself antigen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] +synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] +synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] +is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response +is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen +relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002657 +name: positive regulation of tolerance induction to nonself antigen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] +synonym: "activation of tolerance induction to nonself antigen" NARROW [] +synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] +synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] +is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response +is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen +relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002658 +name: regulation of peripheral tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +relationship: regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002659 +name: negative regulation of peripheral tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] +synonym: "down regulation of peripheral tolerance induction" EXACT [] +synonym: "down-regulation of peripheral tolerance induction" EXACT [] +synonym: "downregulation of peripheral tolerance induction" EXACT [] +synonym: "inhibition of peripheral tolerance induction" NARROW [] +is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response +is_a: GO:0002658 ! regulation of peripheral tolerance induction +relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002660 +name: positive regulation of peripheral tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] +synonym: "activation of peripheral tolerance induction" NARROW [] +synonym: "stimulation of peripheral tolerance induction" NARROW [] +synonym: "up regulation of peripheral tolerance induction" EXACT [] +synonym: "up-regulation of peripheral tolerance induction" EXACT [] +synonym: "upregulation of peripheral tolerance induction" EXACT [] +is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response +is_a: GO:0002658 ! regulation of peripheral tolerance induction +relationship: positively_regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002661 +name: regulation of B cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] +synonym: "regulation of B lymphocyte tolerance induction" EXACT [] +synonym: "regulation of B-cell tolerance induction" EXACT [] +synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002662 +name: negative regulation of B cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] +synonym: "down regulation of B cell tolerance induction" EXACT [] +synonym: "down-regulation of B cell tolerance induction" EXACT [] +synonym: "downregulation of B cell tolerance induction" EXACT [] +synonym: "inhibition of B cell tolerance induction" NARROW [] +synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] +synonym: "negative regulation of B-cell tolerance induction" EXACT [] +synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002661 ! regulation of B cell tolerance induction +relationship: negatively_regulates GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002663 +name: positive regulation of B cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] +synonym: "activation of B cell tolerance induction" NARROW [] +synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] +synonym: "positive regulation of B-cell tolerance induction" EXACT [] +synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] +synonym: "stimulation of B cell tolerance induction" NARROW [] +synonym: "up regulation of B cell tolerance induction" EXACT [] +synonym: "up-regulation of B cell tolerance induction" EXACT [] +synonym: "upregulation of B cell tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002661 ! regulation of B cell tolerance induction +relationship: positively_regulates GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002664 +name: regulation of T cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] +synonym: "regulation of T lymphocyte tolerance induction" EXACT [] +synonym: "regulation of T-cell tolerance induction" EXACT [] +synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002665 +name: negative regulation of T cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] +synonym: "down regulation of T cell tolerance induction" EXACT [] +synonym: "down-regulation of T cell tolerance induction" EXACT [] +synonym: "downregulation of T cell tolerance induction" EXACT [] +synonym: "inhibition of T cell tolerance induction" NARROW [] +synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] +synonym: "negative regulation of T-cell tolerance induction" EXACT [] +synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002664 ! regulation of T cell tolerance induction +relationship: negatively_regulates GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002666 +name: positive regulation of T cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] +synonym: "activation of T cell tolerance induction" NARROW [] +synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] +synonym: "positive regulation of T-cell tolerance induction" EXACT [] +synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] +synonym: "stimulation of T cell tolerance induction" NARROW [] +synonym: "up regulation of T cell tolerance induction" EXACT [] +synonym: "up-regulation of T cell tolerance induction" EXACT [] +synonym: "upregulation of T cell tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002664 ! regulation of T cell tolerance induction +relationship: positively_regulates GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002667 +name: regulation of T cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] +synonym: "regulation of T lymphocyte anergy" EXACT [] +synonym: "regulation of T-cell anergy" EXACT [] +synonym: "regulation of T-lymphocyte anergy" EXACT [] +is_a: GO:0002664 ! regulation of T cell tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: regulates GO:0002870 ! T cell anergy + +[Term] +id: GO:0002668 +name: negative regulation of T cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] +synonym: "down regulation of T cell anergy" EXACT [] +synonym: "down-regulation of T cell anergy" EXACT [] +synonym: "downregulation of T cell anergy" EXACT [] +synonym: "inhibition of T cell anergy" NARROW [] +synonym: "negative regulation of T lymphocyte anergy" EXACT [] +synonym: "negative regulation of T-cell anergy" EXACT [] +synonym: "negative regulation of T-lymphocyte anergy" EXACT [] +is_a: GO:0002665 ! negative regulation of T cell tolerance induction +is_a: GO:0002667 ! regulation of T cell anergy +is_a: GO:0002912 ! negative regulation of lymphocyte anergy +relationship: negatively_regulates GO:0002870 ! T cell anergy + +[Term] +id: GO:0002669 +name: positive regulation of T cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] +synonym: "activation of T cell anergy" NARROW [] +synonym: "positive regulation of T lymphocyte anergy" EXACT [] +synonym: "positive regulation of T-cell anergy" EXACT [] +synonym: "positive regulation of T-lymphocyte anergy" EXACT [] +synonym: "stimulation of T cell anergy" NARROW [] +synonym: "up regulation of T cell anergy" EXACT [] +synonym: "up-regulation of T cell anergy" EXACT [] +synonym: "upregulation of T cell anergy" EXACT [] +is_a: GO:0002666 ! positive regulation of T cell tolerance induction +is_a: GO:0002667 ! regulation of T cell anergy +is_a: GO:0002913 ! positive regulation of lymphocyte anergy +relationship: positively_regulates GO:0002870 ! T cell anergy + +[Term] +id: GO:0002670 +name: regulation of B cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] +synonym: "regulation of B lymphocyte anergy" EXACT [] +synonym: "regulation of B-cell anergy" EXACT [] +synonym: "regulation of B-lymphocyte anergy" EXACT [] +is_a: GO:0002661 ! regulation of B cell tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: regulates GO:0002515 ! B cell anergy + +[Term] +id: GO:0002671 +name: negative regulation of B cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] +synonym: "down regulation of B cell anergy" EXACT [] +synonym: "down-regulation of B cell anergy" EXACT [] +synonym: "downregulation of B cell anergy" EXACT [] +synonym: "inhibition of B cell anergy" NARROW [] +synonym: "negative regulation of B lymphocyte anergy" EXACT [] +synonym: "negative regulation of B-cell anergy" EXACT [] +synonym: "negative regulation of B-lymphocyte anergy" EXACT [] +is_a: GO:0002662 ! negative regulation of B cell tolerance induction +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002912 ! negative regulation of lymphocyte anergy +relationship: negatively_regulates GO:0002515 ! B cell anergy + +[Term] +id: GO:0002672 +name: positive regulation of B cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] +synonym: "activation of B cell anergy" NARROW [] +synonym: "positive regulation of B lymphocyte anergy" EXACT [] +synonym: "positive regulation of B-cell anergy" EXACT [] +synonym: "positive regulation of B-lymphocyte anergy" EXACT [] +synonym: "stimulation of B cell anergy" NARROW [] +synonym: "up regulation of B cell anergy" EXACT [] +synonym: "up-regulation of B cell anergy" EXACT [] +synonym: "upregulation of B cell anergy" EXACT [] +is_a: GO:0002663 ! positive regulation of B cell tolerance induction +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002913 ! positive regulation of lymphocyte anergy +relationship: positively_regulates GO:0002515 ! B cell anergy + +[Term] +id: GO:0002673 +name: regulation of acute inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] +is_a: GO:0050727 ! regulation of inflammatory response +relationship: regulates GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002674 +name: negative regulation of acute inflammatory response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] +synonym: "down regulation of acute inflammatory response" EXACT [] +synonym: "down-regulation of acute inflammatory response" EXACT [] +synonym: "downregulation of acute inflammatory response" EXACT [] +synonym: "inhibition of acute inflammatory response" NARROW [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0050728 ! negative regulation of inflammatory response +relationship: negatively_regulates GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002675 +name: positive regulation of acute inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] +synonym: "activation of acute inflammatory response" NARROW [] +synonym: "stimulation of acute inflammatory response" NARROW [] +synonym: "up regulation of acute inflammatory response" EXACT [] +synonym: "up-regulation of acute inflammatory response" EXACT [] +synonym: "upregulation of acute inflammatory response" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0050729 ! positive regulation of inflammatory response +relationship: positively_regulates GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002676 +name: regulation of chronic inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] +is_a: GO:0050727 ! regulation of inflammatory response +relationship: regulates GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002677 +name: negative regulation of chronic inflammatory response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] +synonym: "down regulation of chronic inflammatory response" EXACT [] +synonym: "down-regulation of chronic inflammatory response" EXACT [] +synonym: "downregulation of chronic inflammatory response" EXACT [] +synonym: "inhibition of chronic inflammatory response" NARROW [] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0050728 ! negative regulation of inflammatory response +relationship: negatively_regulates GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002678 +name: positive regulation of chronic inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] +synonym: "activation of chronic inflammatory response" NARROW [] +synonym: "stimulation of chronic inflammatory response" NARROW [] +synonym: "up regulation of chronic inflammatory response" EXACT [] +synonym: "up-regulation of chronic inflammatory response" EXACT [] +synonym: "upregulation of chronic inflammatory response" EXACT [] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0050729 ! positive regulation of inflammatory response +relationship: positively_regulates GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002679 +name: respiratory burst during defense response +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12789499] +is_a: GO:0002252 ! immune effector process +is_a: GO:0045087 ! innate immune response +is_a: GO:0045730 ! respiratory burst + +[Term] +id: GO:0002680 +name: pro-T cell lineage commitment +namespace: biological_process +def: "The process by which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "pro-T cell fate commitment" EXACT [] +synonym: "pro-T lymphocyte fate commitment" EXACT [] +synonym: "pro-T lymphocyte lineage commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0002572 ! pro-T cell differentiation + +[Term] +id: GO:0002681 +name: somatic recombination of T cell receptor gene segments +namespace: biological_process +def: "The process by which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic recombination of TCR gene segments" EXACT [] +is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus +is_a: GO:0002568 ! somatic diversification of T cell receptor genes + +[Term] +id: GO:0002682 +name: regulation of immune system process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0002376 ! immune system process + +[Term] +id: GO:0002683 +name: negative regulation of immune system process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] +synonym: "down regulation of immune system process" EXACT [] +synonym: "down-regulation of immune system process" EXACT [] +synonym: "downregulation of immune system process" EXACT [] +synonym: "inhibition of immune system process" NARROW [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0002376 ! immune system process + +[Term] +id: GO:0002684 +name: positive regulation of immune system process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] +synonym: "activation of immune system process" NARROW [] +synonym: "stimulation of immune system process" NARROW [] +synonym: "up regulation of immune system process" EXACT [] +synonym: "up-regulation of immune system process" EXACT [] +synonym: "upregulation of immune system process" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0002376 ! immune system process + +[Term] +id: GO:0002685 +name: regulation of leukocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] +synonym: "regulation of immune cell migration" EXACT [] +synonym: "regulation of leucocyte migration" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002686 +name: negative regulation of leukocyte migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] +synonym: "down regulation of leukocyte migration" EXACT [] +synonym: "down-regulation of leukocyte migration" EXACT [] +synonym: "downregulation of leukocyte migration" EXACT [] +synonym: "inhibition of leukocyte migration" NARROW [] +synonym: "negative regulation of immune cell migration" EXACT [] +synonym: "negative regulation of leucocyte migration" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0002685 ! regulation of leukocyte migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002687 +name: positive regulation of leukocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] +synonym: "activation of leukocyte migration" NARROW [] +synonym: "positive regulation of immune cell migration" EXACT [] +synonym: "positive regulation of leucocyte migration" EXACT [] +synonym: "stimulation of leukocyte migration" NARROW [] +synonym: "up regulation of leukocyte migration" EXACT [] +synonym: "up-regulation of leukocyte migration" EXACT [] +synonym: "upregulation of leukocyte migration" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002685 ! regulation of leukocyte migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002688 +name: regulation of leukocyte chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] +synonym: "regulation of immune cell chemotaxis" EXACT [] +synonym: "regulation of leucocyte chemotaxis" EXACT [] +is_a: GO:0002685 ! regulation of leukocyte migration +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002689 +name: negative regulation of leukocyte chemotaxis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] +synonym: "down regulation of leukocyte chemotaxis" EXACT [] +synonym: "down-regulation of leukocyte chemotaxis" EXACT [] +synonym: "downregulation of leukocyte chemotaxis" EXACT [] +synonym: "inhibition of leukocyte chemotaxis" NARROW [] +synonym: "negative regulation of immune cell chemotaxis" EXACT [] +synonym: "negative regulation of leucocyte chemotaxis" EXACT [] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:0050922 ! negative regulation of chemotaxis +relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002690 +name: positive regulation of leukocyte chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] +synonym: "activation of leukocyte chemotaxis" NARROW [] +synonym: "positive regulation of immune cell chemotaxis" EXACT [] +synonym: "positive regulation of leucocyte chemotaxis" EXACT [] +synonym: "stimulation of leukocyte chemotaxis" NARROW [] +synonym: "up regulation of leukocyte chemotaxis" EXACT [] +synonym: "up-regulation of leukocyte chemotaxis" EXACT [] +synonym: "upregulation of leukocyte chemotaxis" EXACT [] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:0050921 ! positive regulation of chemotaxis +relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002691 +name: regulation of cellular extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] +is_a: GO:0002685 ! regulation of leukocyte migration +relationship: regulates GO:0045123 ! cellular extravasation + +[Term] +id: GO:0002692 +name: negative regulation of cellular extravasation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] +synonym: "down regulation of cellular extravasation" EXACT [] +synonym: "down-regulation of cellular extravasation" EXACT [] +synonym: "downregulation of cellular extravasation" EXACT [] +synonym: "inhibition of cellular extravasation" NARROW [] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:0002691 ! regulation of cellular extravasation +relationship: negatively_regulates GO:0045123 ! cellular extravasation + +[Term] +id: GO:0002693 +name: positive regulation of cellular extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] +synonym: "activation of cellular extravasation" NARROW [] +synonym: "stimulation of cellular extravasation" NARROW [] +synonym: "up regulation of cellular extravasation" EXACT [] +synonym: "up-regulation of cellular extravasation" EXACT [] +synonym: "upregulation of cellular extravasation" EXACT [] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:0002691 ! regulation of cellular extravasation +relationship: positively_regulates GO:0045123 ! cellular extravasation + +[Term] +id: GO:0002694 +name: regulation of leukocyte activation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] +synonym: "regulation of immune cell activation" EXACT [] +synonym: "regulation of leucocyte activation" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002695 +name: negative regulation of leukocyte activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] +synonym: "down regulation of leukocyte activation" EXACT [] +synonym: "down-regulation of leukocyte activation" EXACT [] +synonym: "downregulation of leukocyte activation" EXACT [] +synonym: "inhibition of leukocyte activation" NARROW [] +synonym: "negative regulation of immune cell activation" EXACT [] +synonym: "negative regulation of leucocyte activation" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0050866 ! negative regulation of cell activation +relationship: negatively_regulates GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002696 +name: positive regulation of leukocyte activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] +synonym: "activation of leukocyte activation" NARROW [] +synonym: "positive regulation of immune cell activation" EXACT [] +synonym: "positive regulation of leucocyte activation" EXACT [] +synonym: "stimulation of leukocyte activation" NARROW [] +synonym: "up regulation of leukocyte activation" EXACT [] +synonym: "up-regulation of leukocyte activation" EXACT [] +synonym: "upregulation of leukocyte activation" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0050867 ! positive regulation of cell activation +relationship: positively_regulates GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002697 +name: regulation of immune effector process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002252 ! immune effector process + +[Term] +id: GO:0002698 +name: negative regulation of immune effector process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] +synonym: "down regulation of immune effector process" EXACT [] +synonym: "down-regulation of immune effector process" EXACT [] +synonym: "downregulation of immune effector process" EXACT [] +synonym: "inhibition of immune effector process" NARROW [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0002697 ! regulation of immune effector process +relationship: negatively_regulates GO:0002252 ! immune effector process + +[Term] +id: GO:0002699 +name: positive regulation of immune effector process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] +synonym: "activation of immune effector process" NARROW [] +synonym: "stimulation of immune effector process" NARROW [] +synonym: "up regulation of immune effector process" EXACT [] +synonym: "up-regulation of immune effector process" EXACT [] +synonym: "upregulation of immune effector process" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002697 ! regulation of immune effector process +relationship: positively_regulates GO:0002252 ! immune effector process + +[Term] +id: GO:0002700 +name: regulation of production of molecular mediator of immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] +is_a: GO:0002697 ! regulation of immune effector process +relationship: regulates GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002701 +name: negative regulation of production of molecular mediator of immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] +synonym: "down regulation of production of molecular mediator of immune response" EXACT [] +synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] +synonym: "downregulation of production of molecular mediator of immune response" EXACT [] +synonym: "inhibition of production of molecular mediator of immune response" NARROW [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002702 +name: positive regulation of production of molecular mediator of immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] +synonym: "activation of production of molecular mediator of immune response" NARROW [] +synonym: "stimulation of production of molecular mediator of immune response" NARROW [] +synonym: "up regulation of production of molecular mediator of immune response" EXACT [] +synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] +synonym: "upregulation of production of molecular mediator of immune response" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002703 +name: regulation of leukocyte mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] +synonym: "regulation of immune cell mediated immunity" EXACT [] +synonym: "regulation of leucocyte mediated immunity" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +relationship: regulates GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002704 +name: negative regulation of leukocyte mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] +synonym: "down regulation of leukocyte mediated immunity" EXACT [] +synonym: "down-regulation of leukocyte mediated immunity" EXACT [] +synonym: "downregulation of leukocyte mediated immunity" EXACT [] +synonym: "inhibition of leukocyte mediated immunity" NARROW [] +synonym: "negative regulation of immune cell mediated immunity" EXACT [] +synonym: "negative regulation of leucocyte mediated immunity" EXACT [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002705 +name: positive regulation of leukocyte mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] +synonym: "activation of leukocyte mediated immunity" NARROW [] +synonym: "positive regulation of immune cell mediated immunity" EXACT [] +synonym: "positive regulation of leucocyte mediated immunity" EXACT [] +synonym: "stimulation of leukocyte mediated immunity" NARROW [] +synonym: "up regulation of leukocyte mediated immunity" EXACT [] +synonym: "up-regulation of leukocyte mediated immunity" EXACT [] +synonym: "upregulation of leukocyte mediated immunity" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002706 +name: regulation of lymphocyte mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: regulates GO:0002449 ! lymphocyte mediated immunity + +[Term] +id: GO:0002707 +name: negative regulation of lymphocyte mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] +synonym: "down regulation of lymphocyte mediated immunity" EXACT [] +synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] +synonym: "downregulation of lymphocyte mediated immunity" EXACT [] +synonym: "inhibition of lymphocyte mediated immunity" NARROW [] +is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity + +[Term] +id: GO:0002708 +name: positive regulation of lymphocyte mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] +synonym: "activation of lymphocyte mediated immunity" NARROW [] +synonym: "stimulation of lymphocyte mediated immunity" NARROW [] +synonym: "up regulation of lymphocyte mediated immunity" EXACT [] +synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] +synonym: "upregulation of lymphocyte mediated immunity" EXACT [] +is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity + +[Term] +id: GO:0002709 +name: regulation of T cell mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] +synonym: "regulation of T lymphocyte mediated immunity" EXACT [] +synonym: "regulation of T-cell mediated immunity" EXACT [] +synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002710 +name: negative regulation of T cell mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] +synonym: "down regulation of T cell mediated immunity" EXACT [] +synonym: "down-regulation of T cell mediated immunity" EXACT [] +synonym: "downregulation of T cell mediated immunity" EXACT [] +synonym: "inhibition of T cell mediated immunity" NARROW [] +synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] +synonym: "negative regulation of T-cell mediated immunity" EXACT [] +synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002711 +name: positive regulation of T cell mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] +synonym: "activation of T cell mediated immunity" NARROW [] +synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] +synonym: "positive regulation of T-cell mediated immunity" EXACT [] +synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] +synonym: "stimulation of T cell mediated immunity" NARROW [] +synonym: "up regulation of T cell mediated immunity" EXACT [] +synonym: "up-regulation of T cell mediated immunity" EXACT [] +synonym: "upregulation of T cell mediated immunity" EXACT [] +is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002712 +name: regulation of B cell mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] +synonym: "regulation of B lymphocyte mediated immunity" EXACT [] +synonym: "regulation of B-cell mediated immunity" EXACT [] +synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002713 +name: negative regulation of B cell mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] +synonym: "down regulation of B cell mediated immunity" EXACT [] +synonym: "down-regulation of B cell mediated immunity" EXACT [] +synonym: "downregulation of B cell mediated immunity" EXACT [] +synonym: "inhibition of B cell mediated immunity" NARROW [] +synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] +synonym: "negative regulation of B-cell mediated immunity" EXACT [] +synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002714 +name: positive regulation of B cell mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] +synonym: "activation of B cell mediated immunity" NARROW [] +synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] +synonym: "positive regulation of B-cell mediated immunity" EXACT [] +synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] +synonym: "stimulation of B cell mediated immunity" NARROW [] +synonym: "up regulation of B cell mediated immunity" EXACT [] +synonym: "up-regulation of B cell mediated immunity" EXACT [] +synonym: "upregulation of B cell mediated immunity" EXACT [] +is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002715 +name: regulation of natural killer cell mediated immunity +namespace: biological_process +alt_id: GO:0045845 +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] +synonym: "regulation of natural killer cell activity" RELATED [] +synonym: "regulation of NK cell mediated immunity" EXACT [] +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0002716 +name: negative regulation of natural killer cell mediated immunity +namespace: biological_process +alt_id: GO:0030102 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] +synonym: "down regulation of natural killer cell mediated immunity" EXACT [] +synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] +synonym: "downregulation of natural killer cell mediated immunity" EXACT [] +synonym: "inhibition of natural killer cell mediated immunity" NARROW [] +synonym: "negative regulation of natural killer cell activity" RELATED [] +synonym: "negative regulation of NK cell activity" RELATED [] +synonym: "negative regulation of NK cell mediated immunity" EXACT [] +is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0002717 +name: positive regulation of natural killer cell mediated immunity +namespace: biological_process +alt_id: GO:0045846 +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] +synonym: "activation of natural killer cell mediated immunity" NARROW [] +synonym: "positive regulation of natural killer cell activity" RELATED [] +synonym: "positive regulation of NK cell activity" RELATED [] +synonym: "positive regulation of NK cell mediated immunity" EXACT [] +synonym: "stimulation of natural killer cell mediated immunity" NARROW [] +synonym: "up regulation of natural killer cell mediated immunity" EXACT [] +synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] +synonym: "upregulation of natural killer cell mediated immunity" EXACT [] +is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0045089 ! positive regulation of innate immune response +relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0002718 +name: regulation of cytokine production during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cytokine production during immune response." [GOC:add] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: regulates GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002719 +name: negative regulation of cytokine production during immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production during an immune response." [GOC:add] +synonym: "down regulation of cytokine production during immune response" EXACT [] +synonym: "down-regulation of cytokine production during immune response" EXACT [] +synonym: "downregulation of cytokine production during immune response" EXACT [] +synonym: "inhibition of cytokine production during immune response" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: negatively_regulates GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002720 +name: positive regulation of cytokine production during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cytokine production during immune response." [GOC:add] +synonym: "activation of cytokine production during immune response" NARROW [] +synonym: "stimulation of cytokine production during immune response" NARROW [] +synonym: "up regulation of cytokine production during immune response" EXACT [] +synonym: "up-regulation of cytokine production during immune response" EXACT [] +synonym: "upregulation of cytokine production during immune response" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: positively_regulates GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0002721 +name: regulation of B cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] +synonym: "regulation of B lymphocyte cytokine production" EXACT [] +synonym: "regulation of B-cell cytokine production" EXACT [] +synonym: "regulation of B-lymphocyte cytokine production" EXACT [] +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: regulates GO:0002368 ! B cell cytokine production + +[Term] +id: GO:0002722 +name: negative regulation of B cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] +synonym: "down regulation of B cell cytokine production" EXACT [] +synonym: "down-regulation of B cell cytokine production" EXACT [] +synonym: "downregulation of B cell cytokine production" EXACT [] +synonym: "inhibition of B cell cytokine production" NARROW [] +synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] +synonym: "negative regulation of B-cell cytokine production" EXACT [] +synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production during immune response +is_a: GO:0002721 ! regulation of B cell cytokine production +relationship: negatively_regulates GO:0002368 ! B cell cytokine production + +[Term] +id: GO:0002723 +name: positive regulation of B cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] +synonym: "activation of B cell cytokine production" NARROW [] +synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] +synonym: "positive regulation of B-cell cytokine production" EXACT [] +synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] +synonym: "stimulation of B cell cytokine production" NARROW [] +synonym: "up regulation of B cell cytokine production" EXACT [] +synonym: "up-regulation of B cell cytokine production" EXACT [] +synonym: "upregulation of B cell cytokine production" EXACT [] +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production during immune response +is_a: GO:0002721 ! regulation of B cell cytokine production +relationship: positively_regulates GO:0002368 ! B cell cytokine production + +[Term] +id: GO:0002724 +name: regulation of T cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] +synonym: "regulation of T lymphocyte cytokine production" EXACT [] +synonym: "regulation of T-cell cytokine production" EXACT [] +synonym: "regulation of T-lymphocyte cytokine production" EXACT [] +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: regulates GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0002725 +name: negative regulation of T cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] +synonym: "down regulation of T cell cytokine production" EXACT [] +synonym: "down-regulation of T cell cytokine production" EXACT [] +synonym: "downregulation of T cell cytokine production" EXACT [] +synonym: "inhibition of T cell cytokine production" NARROW [] +synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] +synonym: "negative regulation of T-cell cytokine production" EXACT [] +synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production during immune response +is_a: GO:0002724 ! regulation of T cell cytokine production +relationship: negatively_regulates GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0002726 +name: positive regulation of T cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] +synonym: "activation of T cell cytokine production" NARROW [] +synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] +synonym: "positive regulation of T-cell cytokine production" EXACT [] +synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] +synonym: "stimulation of T cell cytokine production" NARROW [] +synonym: "up regulation of T cell cytokine production" EXACT [] +synonym: "up-regulation of T cell cytokine production" EXACT [] +synonym: "upregulation of T cell cytokine production" EXACT [] +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production during immune response +is_a: GO:0002724 ! regulation of T cell cytokine production +relationship: positively_regulates GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0002727 +name: regulation of natural killer cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] +synonym: "regulation of NK cell cytokine production" EXACT [] +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: regulates GO:0002370 ! natural killer cell cytokine production + +[Term] +id: GO:0002728 +name: negative regulation of natural killer cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] +synonym: "down regulation of natural killer cell cytokine production" EXACT [] +synonym: "down-regulation of natural killer cell cytokine production" EXACT [] +synonym: "downregulation of natural killer cell cytokine production" EXACT [] +synonym: "inhibition of natural killer cell cytokine production" NARROW [] +synonym: "negative regulation of NK cell cytokine production" EXACT [] +is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production during immune response +is_a: GO:0002727 ! regulation of natural killer cell cytokine production +relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production + +[Term] +id: GO:0002729 +name: positive regulation of natural killer cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] +synonym: "activation of natural killer cell cytokine production" NARROW [] +synonym: "positive regulation of NK cell cytokine production" EXACT [] +synonym: "stimulation of natural killer cell cytokine production" NARROW [] +synonym: "up regulation of natural killer cell cytokine production" EXACT [] +synonym: "up-regulation of natural killer cell cytokine production" EXACT [] +synonym: "upregulation of natural killer cell cytokine production" EXACT [] +is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production during immune response +is_a: GO:0002727 ! regulation of natural killer cell cytokine production +relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production + +[Term] +id: GO:0002730 +name: regulation of dendritic cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: regulates GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002731 +name: negative regulation of dendritic cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] +synonym: "down regulation of dendritic cell cytokine production" EXACT [] +synonym: "down-regulation of dendritic cell cytokine production" EXACT [] +synonym: "downregulation of dendritic cell cytokine production" EXACT [] +synonym: "inhibition of dendritic cell cytokine production" NARROW [] +is_a: GO:0002719 ! negative regulation of cytokine production during immune response +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002732 +name: positive regulation of dendritic cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] +synonym: "activation of dendritic cell cytokine production" NARROW [] +synonym: "stimulation of dendritic cell cytokine production" NARROW [] +synonym: "up regulation of dendritic cell cytokine production" EXACT [] +synonym: "up-regulation of dendritic cell cytokine production" EXACT [] +synonym: "upregulation of dendritic cell cytokine production" EXACT [] +is_a: GO:0002720 ! positive regulation of cytokine production during immune response +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002733 +name: regulation of myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production + +[Term] +id: GO:0002734 +name: negative regulation of myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] +synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] +is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production +is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production +relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production + +[Term] +id: GO:0002735 +name: positive regulation of myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] +synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] +synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] +synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] +is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production +is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production +relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production + +[Term] +id: GO:0002736 +name: regulation of plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production + +[Term] +id: GO:0002737 +name: negative regulation of plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] +synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] +is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production +is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production +relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production + +[Term] +id: GO:0002738 +name: positive regulation of plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] +synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] +synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] +synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] +is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production +is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production +relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production + +[Term] +id: GO:0002739 +name: regulation of cytokine secretion during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cytokine secretion during immune response." [GOC:add] +is_a: GO:0002718 ! regulation of cytokine production during immune response +is_a: GO:0050707 ! regulation of cytokine secretion +relationship: regulates GO:0002374 ! cytokine secretion during immune response + +[Term] +id: GO:0002740 +name: negative regulation of cytokine secretion during immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion during immune response." [GOC:add] +synonym: "down regulation of cytokine secretion during immune response" EXACT [] +synonym: "down-regulation of cytokine secretion during immune response" EXACT [] +synonym: "downregulation of cytokine secretion during immune response" EXACT [] +synonym: "inhibition of cytokine secretion during immune response" NARROW [] +is_a: GO:0002739 ! regulation of cytokine secretion during immune response +is_a: GO:0050710 ! negative regulation of cytokine secretion +relationship: negatively_regulates GO:0002374 ! cytokine secretion during immune response + +[Term] +id: GO:0002741 +name: positive regulation of cytokine secretion during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion during immune response." [GOC:add] +synonym: "activation of cytokine secretion during immune response" NARROW [] +synonym: "stimulation of cytokine secretion during immune response" NARROW [] +synonym: "up regulation of cytokine secretion during immune response" EXACT [] +synonym: "up-regulation of cytokine secretion during immune response" EXACT [] +synonym: "upregulation of cytokine secretion during immune response" EXACT [] +is_a: GO:0002739 ! regulation of cytokine secretion during immune response +is_a: GO:0050715 ! positive regulation of cytokine secretion +relationship: positively_regulates GO:0002374 ! cytokine secretion during immune response + +[Term] +id: GO:0002742 +name: regulation of cytokine biosynthetic process during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis during immune response." [GOC:add] +is_a: GO:0002718 ! regulation of cytokine production during immune response +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0002375 ! cytokine biosynthetic process during immune response + +[Term] +id: GO:0002743 +name: negative regulation of cytokine biosynthetic process during immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis during immune response." [GOC:add] +synonym: "down regulation of cytokine biosynthetic process during immune response" EXACT [] +synonym: "down-regulation of cytokine biosynthetic process during immune response" EXACT [] +synonym: "downregulation of cytokine biosynthetic process during immune response" EXACT [] +synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] +is_a: GO:0002742 ! regulation of cytokine biosynthetic process during immune response +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process during immune response + +[Term] +id: GO:0002744 +name: positive regulation of cytokine biosynthetic process during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis during immune response." [GOC:add] +synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] +synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] +synonym: "up regulation of cytokine biosynthetic process during immune response" EXACT [] +synonym: "up-regulation of cytokine biosynthetic process during immune response" EXACT [] +synonym: "upregulation of cytokine biosynthetic process during immune response" EXACT [] +is_a: GO:0002742 ! regulation of cytokine biosynthetic process during immune response +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process during immune response + +[Term] +id: GO:0002745 +name: antigen processing and presentation initiated by receptor mediated uptake of antigen +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002746 +name: antigen processing and presentation following pinocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002747 +name: antigen processing and presentation following phagocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002748 +name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] +synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] +is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen + +[Term] +id: GO:0002749 +name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen +namespace: biological_process +def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15596122] +synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] +is_a: GO:0002747 ! antigen processing and presentation following phagocytosis +is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen + +[Term] +id: GO:0002750 +name: antigen processing and presentation following macropinocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] +is_a: GO:0002746 ! antigen processing and presentation following pinocytosis + +[Term] +id: GO:0002751 +name: antigen processing and presentation following receptor mediated endocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen + +[Term] +id: GO:0002752 +name: cell surface pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] +synonym: "cell surface PAMP receptor signaling pathway" EXACT [] +synonym: "cell surface pathogen receptor signaling pathway" EXACT [] +synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] +synonym: "cell surface PRR signaling pathway" EXACT [] +is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway +is_a: GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0002753 +name: cytoplasmic pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a cytoplasmic pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] +synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] +synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] +synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] +synonym: "cytoplasmic PRR signaling pathway" EXACT [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0002754 +name: intracellular vesicle pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] +synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT [] +synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT [] +synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT [] +synonym: "intracellular vesicle PRR signaling pathway" EXACT [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0002755 +name: MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] +synonym: "MyD88-dependent TLR signaling pathway" EXACT [] +synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0002756 +name: MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] +synonym: "MyD88-independent TLR signaling pathway" EXACT [] +synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0002757 +name: immune response-activating signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] +is_a: GO:0002253 ! activation of immune response +is_a: GO:0002764 ! immune response-regulating signal transduction + +[Term] +id: GO:0002758 +name: innate immune response-activating signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GOC:add, GOC:mtg_15nov05] +comment: This term was added by GO_REF:0000022. +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0002757 ! immune response-activating signal transduction + +[Term] +id: GO:0002759 +name: regulation of antimicrobial humoral response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0002760 +name: positive regulation of antimicrobial humoral response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] +synonym: "activation of antimicrobial humoral response" NARROW [] +synonym: "stimulation of antimicrobial humoral response" NARROW [] +synonym: "up regulation of antimicrobial humoral response" EXACT [] +synonym: "up-regulation of antimicrobial humoral response" EXACT [] +synonym: "upregulation of antimicrobial humoral response" EXACT [] +is_a: GO:0002759 ! regulation of antimicrobial humoral response +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0043902 ! positive regulation of multi-organism process +relationship: positively_regulates GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0002761 +name: regulation of myeloid leukocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: regulates GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0002762 +name: negative regulation of myeloid leukocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] +synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] +synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0002763 +name: positive regulation of myeloid leukocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] +synonym: "activation of myeloid leukocyte differentiation" NARROW [] +synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] +synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0002764 +name: immune response-regulating signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +is_a: GO:0007165 ! signal transduction +is_a: GO:0050776 ! regulation of immune response + +[Term] +id: GO:0002765 +name: immune response-inhibiting signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002764 ! immune response-regulating signal transduction + +[Term] +id: GO:0002766 +name: innate immune response-inhibiting signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +is_a: GO:0002765 ! immune response-inhibiting signal transduction + +[Term] +id: GO:0002767 +name: immune response-inhibiting cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002765 ! immune response-inhibiting signal transduction +is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway + +[Term] +id: GO:0002768 +name: immune response-regulating cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002764 ! immune response-regulating signal transduction +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0002769 +name: natural killer cell inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +synonym: "inhibitory KIR signaling pathway" NARROW [] +synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] +synonym: "Ly49 inhibitory receptor signaling pathway" NARROW [] +synonym: "natural killer cell inhibitory signalling pathway" EXACT [] +synonym: "NK cell inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002770 +name: T cell inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] +synonym: "T cell inhibitory signalling pathway" EXACT [] +synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] +synonym: "T-cell inhibitory signaling pathway" EXACT [] +synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002771 +name: inhibitory killer cell immunoglobulin-like receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] +synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] +synonym: "KIR signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002772 +name: inhibitory C-type lectin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] +synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] +synonym: "Ly49 inhibitory receptor signaling pathway" NARROW [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002773 +name: B cell inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] +synonym: "B cell inhibitory signalling pathway" EXACT [] +synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] +synonym: "B-cell inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002774 +name: Fc receptor mediated inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] +synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002775 +name: antimicrobial peptide production +namespace: biological_process +def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002440 ! production of molecular mediator of immune response +relationship: part_of GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0002776 +name: antimicrobial peptide secretion +namespace: biological_process +def: "The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002790 ! peptide secretion +relationship: part_of GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002777 +name: antimicrobial peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0043043 ! peptide biosynthetic process +relationship: part_of GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002778 +name: antibacterial peptide production +namespace: biological_process +def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002775 ! antimicrobial peptide production +relationship: part_of GO:0019731 ! antibacterial humoral response + +[Term] +id: GO:0002779 +name: antibacterial peptide secretion +namespace: biological_process +def: "The regulated release of an antibacterial peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002776 ! antimicrobial peptide secretion +relationship: part_of GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002780 +name: antibacterial peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002777 ! antimicrobial peptide biosynthetic process +relationship: part_of GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002781 +name: antifungal peptide production +namespace: biological_process +def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002775 ! antimicrobial peptide production +relationship: part_of GO:0019732 ! antifungal humoral response + +[Term] +id: GO:0002782 +name: antifungal peptide secretion +namespace: biological_process +def: "The regulated release of an antifungal peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002776 ! antimicrobial peptide secretion +relationship: part_of GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002783 +name: antifungal peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] +is_a: GO:0002777 ! antimicrobial peptide biosynthetic process +relationship: part_of GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002784 +name: regulation of antimicrobial peptide production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +is_a: GO:0002759 ! regulation of antimicrobial humoral response +relationship: regulates GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002785 +name: negative regulation of antimicrobial peptide production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] +synonym: "down regulation of antimicrobial peptide production" EXACT [] +synonym: "down-regulation of antimicrobial peptide production" EXACT [] +synonym: "downregulation of antimicrobial peptide production" EXACT [] +synonym: "inhibition of antimicrobial peptide production" NARROW [] +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +is_a: GO:0002784 ! regulation of antimicrobial peptide production +relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002786 +name: regulation of antibacterial peptide production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0031347 ! regulation of defense response +relationship: regulates GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002787 +name: negative regulation of antibacterial peptide production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] +synonym: "down regulation of antibacterial peptide production" EXACT [] +synonym: "down-regulation of antibacterial peptide production" EXACT [] +synonym: "downregulation of antibacterial peptide production" EXACT [] +synonym: "inhibition of antibacterial peptide production" NARROW [] +is_a: GO:0002785 ! negative regulation of antimicrobial peptide production +is_a: GO:0002786 ! regulation of antibacterial peptide production +relationship: negatively_regulates GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002788 +name: regulation of antifungal peptide production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0031347 ! regulation of defense response +relationship: regulates GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002789 +name: negative regulation of antifungal peptide production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] +synonym: "down regulation of antifungal peptide production" EXACT [] +synonym: "down-regulation of antifungal peptide production" EXACT [] +synonym: "downregulation of antifungal peptide production" EXACT [] +synonym: "inhibition of antifungal peptide production" NARROW [] +is_a: GO:0002785 ! negative regulation of antimicrobial peptide production +is_a: GO:0002788 ! regulation of antifungal peptide production +relationship: negatively_regulates GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002790 +name: peptide secretion +namespace: biological_process +def: "The regulated release of a peptide from a cell or group of cells." [GOC:add] +is_a: GO:0015833 ! peptide transport +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0002791 +name: regulation of peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0002790 ! peptide secretion + +[Term] +id: GO:0002792 +name: negative regulation of peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] +synonym: "down regulation of peptide secretion" EXACT [] +synonym: "down-regulation of peptide secretion" EXACT [] +synonym: "downregulation of peptide secretion" EXACT [] +synonym: "inhibition of peptide secretion" NARROW [] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0002790 ! peptide secretion + +[Term] +id: GO:0002793 +name: positive regulation of peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] +synonym: "activation of peptide secretion" NARROW [] +synonym: "stimulation of peptide secretion" NARROW [] +synonym: "up regulation of peptide secretion" EXACT [] +synonym: "up-regulation of peptide secretion" EXACT [] +synonym: "upregulation of peptide secretion" EXACT [] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0002790 ! peptide secretion + +[Term] +id: GO:0002794 +name: regulation of antimicrobial peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0002791 ! regulation of peptide secretion +relationship: regulates GO:0002776 ! antimicrobial peptide secretion + +[Term] +id: GO:0002795 +name: negative regulation of antimicrobial peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] +synonym: "down regulation of antimicrobial peptide secretion" EXACT [] +synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] +synonym: "downregulation of antimicrobial peptide secretion" EXACT [] +synonym: "inhibition of antimicrobial peptide secretion" NARROW [] +is_a: GO:0002792 ! negative regulation of peptide secretion +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion + +[Term] +id: GO:0002796 +name: positive regulation of antimicrobial peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] +synonym: "activation of antimicrobial peptide secretion" NARROW [] +synonym: "stimulation of antimicrobial peptide secretion" NARROW [] +synonym: "up regulation of antimicrobial peptide secretion" EXACT [] +synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] +synonym: "upregulation of antimicrobial peptide secretion" EXACT [] +is_a: GO:0002793 ! positive regulation of peptide secretion +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion + +[Term] +id: GO:0002797 +name: regulation of antibacterial peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] +is_a: GO:0002786 ! regulation of antibacterial peptide production +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: regulates GO:0002779 ! antibacterial peptide secretion + +[Term] +id: GO:0002798 +name: negative regulation of antibacterial peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] +synonym: "down regulation of antibacterial peptide secretion" EXACT [] +synonym: "down-regulation of antibacterial peptide secretion" EXACT [] +synonym: "downregulation of antibacterial peptide secretion" EXACT [] +synonym: "inhibition of antibacterial peptide secretion" NARROW [] +is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion +is_a: GO:0002797 ! regulation of antibacterial peptide secretion +relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion + +[Term] +id: GO:0002799 +name: positive regulation of antibacterial peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] +synonym: "activation of antibacterial peptide secretion" NARROW [] +synonym: "stimulation of antibacterial peptide secretion" NARROW [] +synonym: "up regulation of antibacterial peptide secretion" EXACT [] +synonym: "up-regulation of antibacterial peptide secretion" EXACT [] +synonym: "upregulation of antibacterial peptide secretion" EXACT [] +is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion +is_a: GO:0002797 ! regulation of antibacterial peptide secretion +relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion + +[Term] +id: GO:0002800 +name: regulation of antifungal peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] +is_a: GO:0002788 ! regulation of antifungal peptide production +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: regulates GO:0002782 ! antifungal peptide secretion + +[Term] +id: GO:0002801 +name: negative regulation of antifungal peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] +synonym: "down regulation of antifungal peptide secretion" EXACT [] +synonym: "down-regulation of antifungal peptide secretion" EXACT [] +synonym: "downregulation of antifungal peptide secretion" EXACT [] +synonym: "inhibition of antifungal peptide secretion" NARROW [] +is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion +is_a: GO:0002800 ! regulation of antifungal peptide secretion +relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion + +[Term] +id: GO:0002802 +name: positive regulation of antifungal peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] +synonym: "activation of antifungal peptide secretion" NARROW [] +synonym: "stimulation of antifungal peptide secretion" NARROW [] +synonym: "up regulation of antifungal peptide secretion" EXACT [] +synonym: "up-regulation of antifungal peptide secretion" EXACT [] +synonym: "upregulation of antifungal peptide secretion" EXACT [] +is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion +is_a: GO:0002800 ! regulation of antifungal peptide secretion +relationship: positively_regulates GO:0002782 ! antifungal peptide secretion + +[Term] +id: GO:0002803 +name: positive regulation of antibacterial peptide production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] +synonym: "activation of antibacterial peptide production" NARROW [] +synonym: "stimulation of antibacterial peptide production" NARROW [] +synonym: "up regulation of antibacterial peptide production" EXACT [] +synonym: "up-regulation of antibacterial peptide production" EXACT [] +synonym: "upregulation of antibacterial peptide production" EXACT [] +is_a: GO:0002225 ! positive regulation of antimicrobial peptide production +is_a: GO:0002786 ! regulation of antibacterial peptide production +relationship: positively_regulates GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002804 +name: positive regulation of antifungal peptide production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] +synonym: "activation of antifungal peptide production" NARROW [] +synonym: "stimulation of antifungal peptide production" NARROW [] +synonym: "up regulation of antifungal peptide production" EXACT [] +synonym: "up-regulation of antifungal peptide production" EXACT [] +synonym: "upregulation of antifungal peptide production" EXACT [] +is_a: GO:0002225 ! positive regulation of antimicrobial peptide production +is_a: GO:0002788 ! regulation of antifungal peptide production +relationship: positively_regulates GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002805 +name: regulation of antimicrobial peptide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process + +[Term] +id: GO:0002806 +name: negative regulation of antimicrobial peptide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] +synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process + +[Term] +id: GO:0002807 +name: positive regulation of antimicrobial peptide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] +synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] +synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] +synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process + +[Term] +id: GO:0002808 +name: regulation of antibacterial peptide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] +is_a: GO:0002786 ! regulation of antibacterial peptide production +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process + +[Term] +id: GO:0002809 +name: negative regulation of antibacterial peptide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] +synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] +is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process + +[Term] +id: GO:0002810 +name: regulation of antifungal peptide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] +is_a: GO:0002788 ! regulation of antifungal peptide production +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process + +[Term] +id: GO:0002811 +name: negative regulation of antifungal peptide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] +synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] +is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process +relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process + +[Term] +id: GO:0002812 +name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] +is_a: GO:0002780 ! antibacterial peptide biosynthetic process +relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium + +[Term] +id: GO:0002813 +name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria + +[Term] +id: GO:0002814 +name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] +synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] +is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process +is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria + +[Term] +id: GO:0002815 +name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] +is_a: GO:0002780 ! antibacterial peptide biosynthetic process +relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium + +[Term] +id: GO:0002816 +name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria + +[Term] +id: GO:0002817 +name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] +synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] +is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process +is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria + +[Term] +id: GO:0002818 +name: intracellular defense response +namespace: biological_process +def: "A physiological defense response which occurs intracellularly." [GOC:add] +synonym: "intracellular defence response" EXACT [] +is_a: GO:0006968 ! cellular defense response +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0002819 +name: regulation of adaptive immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002820 +name: negative regulation of adaptive immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] +synonym: "down regulation of adaptive immune response" EXACT [] +synonym: "down-regulation of adaptive immune response" EXACT [] +synonym: "downregulation of adaptive immune response" EXACT [] +synonym: "inhibition of adaptive immune response" NARROW [] +is_a: GO:0002819 ! regulation of adaptive immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002821 +name: positive regulation of adaptive immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] +synonym: "activation of adaptive immune response" NARROW [] +synonym: "stimulation of adaptive immune response" NARROW [] +synonym: "up regulation of adaptive immune response" EXACT [] +synonym: "up-regulation of adaptive immune response" EXACT [] +synonym: "upregulation of adaptive immune response" EXACT [] +is_a: GO:0002819 ! regulation of adaptive immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002822 +name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains." [GOC:add, GOC:mtg_sensu] +synonym: "regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +is_a: GO:0002819 ! regulation of adaptive immune response +relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002823 +name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains." [GOC:add, GOC:mtg_sensu] +synonym: "down regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +synonym: "down-regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +synonym: "downregulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +synonym: "inhibition of adaptive immune response (sensu Gnathostomata)" NARROW [] +synonym: "negative regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +is_a: GO:0002820 ! negative regulation of adaptive immune response +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002824 +name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains." [GOC:add, GOC:mtg_sensu] +synonym: "activation of adaptive immune response (sensu Gnathostomata)" NARROW [] +synonym: "positive regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +synonym: "stimulation of adaptive immune response (sensu Gnathostomata)" NARROW [] +synonym: "up regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +synonym: "up-regulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +synonym: "upregulation of adaptive immune response (sensu Gnathostomata)" EXACT [] +is_a: GO:0002821 ! positive regulation of adaptive immune response +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002825 +name: regulation of T-helper 1 type immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0002826 +name: negative regulation of T-helper 1 type immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] +synonym: "down regulation of T-helper 1 type immune response" EXACT [] +synonym: "down-regulation of T-helper 1 type immune response" EXACT [] +synonym: "downregulation of T-helper 1 type immune response" EXACT [] +synonym: "inhibition of T-helper 1 type immune response" NARROW [] +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0002827 +name: positive regulation of T-helper 1 type immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] +synonym: "activation of T-helper 1 type immune response" NARROW [] +synonym: "stimulation of T-helper 1 type immune response" NARROW [] +synonym: "up regulation of T-helper 1 type immune response" EXACT [] +synonym: "up-regulation of T-helper 1 type immune response" EXACT [] +synonym: "upregulation of T-helper 1 type immune response" EXACT [] +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0002828 +name: regulation of T-helper 2 type immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add] +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0042092 ! T-helper 2 type immune response + +[Term] +id: GO:0002829 +name: negative regulation of T-helper 2 type immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add] +synonym: "down regulation of T-helper 2 type immune response" EXACT [] +synonym: "down-regulation of T-helper 2 type immune response" EXACT [] +synonym: "downregulation of T-helper 2 type immune response" EXACT [] +synonym: "inhibition of T-helper 2 type immune response" NARROW [] +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002828 ! regulation of T-helper 2 type immune response +relationship: negatively_regulates GO:0042092 ! T-helper 2 type immune response + +[Term] +id: GO:0002830 +name: positive regulation of T-helper 2 type immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add] +synonym: "activation of T-helper 2 type immune response" NARROW [] +synonym: "stimulation of T-helper 2 type immune response" NARROW [] +synonym: "up regulation of T-helper 2 type immune response" EXACT [] +synonym: "up-regulation of T-helper 2 type immune response" EXACT [] +synonym: "upregulation of T-helper 2 type immune response" EXACT [] +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002828 ! regulation of T-helper 2 type immune response +relationship: positively_regulates GO:0042092 ! T-helper 2 type immune response + +[Term] +id: GO:0002831 +name: regulation of response to biotic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002832 +name: negative regulation of response to biotic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +synonym: "down regulation of response to biotic stimulus" EXACT [] +synonym: "down-regulation of response to biotic stimulus" EXACT [] +synonym: "downregulation of response to biotic stimulus" EXACT [] +synonym: "inhibition of response to biotic stimulus" NARROW [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002833 +name: positive regulation of response to biotic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +synonym: "activation of response to biotic stimulus" NARROW [] +synonym: "stimulation of response to biotic stimulus" NARROW [] +synonym: "up regulation of response to biotic stimulus" EXACT [] +synonym: "up-regulation of response to biotic stimulus" EXACT [] +synonym: "upregulation of response to biotic stimulus" EXACT [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002834 +name: regulation of response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] +synonym: "regulation of response to tumour cell" EXACT [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +relationship: regulates GO:0002347 ! response to tumor cell + +[Term] +id: GO:0002835 +name: negative regulation of response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] +synonym: "down regulation of response to tumor cell" EXACT [] +synonym: "down-regulation of response to tumor cell" EXACT [] +synonym: "downregulation of response to tumor cell" EXACT [] +synonym: "inhibition of response to tumor cell" NARROW [] +synonym: "negative regulation of response to tumour cell" EXACT [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0002834 ! regulation of response to tumor cell +relationship: negatively_regulates GO:0002347 ! response to tumor cell + +[Term] +id: GO:0002836 +name: positive regulation of response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] +synonym: "activation of response to tumor cell" NARROW [] +synonym: "positive regulation of response to tumour cell" EXACT [] +synonym: "stimulation of response to tumor cell" NARROW [] +synonym: "up regulation of response to tumor cell" EXACT [] +synonym: "up-regulation of response to tumor cell" EXACT [] +synonym: "upregulation of response to tumor cell" EXACT [] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0002834 ! regulation of response to tumor cell +relationship: positively_regulates GO:0002347 ! response to tumor cell + +[Term] +id: GO:0002837 +name: regulation of immune response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] +synonym: "regulation of immune response to tumour cell" EXACT [] +is_a: GO:0002834 ! regulation of response to tumor cell +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002838 +name: negative regulation of immune response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] +synonym: "down regulation of immune response to tumor cell" EXACT [] +synonym: "down-regulation of immune response to tumor cell" EXACT [] +synonym: "downregulation of immune response to tumor cell" EXACT [] +synonym: "inhibition of immune response to tumor cell" NARROW [] +synonym: "negative regulation of immune response to tumour cell" EXACT [] +is_a: GO:0002835 ! negative regulation of response to tumor cell +is_a: GO:0002837 ! regulation of immune response to tumor cell +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002839 +name: positive regulation of immune response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] +synonym: "activation of immune response to tumor cell" NARROW [] +synonym: "positive regulation of immune response to tumour cell" EXACT [] +synonym: "stimulation of immune response to tumor cell" NARROW [] +synonym: "up regulation of immune response to tumor cell" EXACT [] +synonym: "up-regulation of immune response to tumor cell" EXACT [] +synonym: "upregulation of immune response to tumor cell" EXACT [] +is_a: GO:0002836 ! positive regulation of response to tumor cell +is_a: GO:0002837 ! regulation of immune response to tumor cell +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002840 +name: regulation of T cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] +synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] +synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] +synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002837 ! regulation of immune response to tumor cell +relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002841 +name: negative regulation of T cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] +synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] +synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] +synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] +synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002838 ! negative regulation of immune response to tumor cell +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002842 +name: positive regulation of T cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] +synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] +synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] +synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] +synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] +synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002839 ! positive regulation of immune response to tumor cell +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002843 +name: regulation of tolerance induction to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] +synonym: "regulation of tolerance induction to tumour cell" EXACT [] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002837 ! regulation of immune response to tumor cell +relationship: regulates GO:0002413 ! tolerance induction to tumor cell + +[Term] +id: GO:0002844 +name: negative regulation of tolerance induction to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] +synonym: "down regulation of tolerance induction to tumor cell" EXACT [] +synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] +synonym: "downregulation of tolerance induction to tumor cell" EXACT [] +synonym: "inhibition of tolerance induction to tumor cell" NARROW [] +synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] +is_a: GO:0002659 ! negative regulation of peripheral tolerance induction +is_a: GO:0002838 ! negative regulation of immune response to tumor cell +is_a: GO:0002843 ! regulation of tolerance induction to tumor cell +relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell + +[Term] +id: GO:0002845 +name: positive regulation of tolerance induction to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] +synonym: "activation of tolerance induction to tumor cell" NARROW [] +synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] +synonym: "stimulation of tolerance induction to tumor cell" NARROW [] +synonym: "up regulation of tolerance induction to tumor cell" EXACT [] +synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] +synonym: "upregulation of tolerance induction to tumor cell" EXACT [] +is_a: GO:0002660 ! positive regulation of peripheral tolerance induction +is_a: GO:0002839 ! positive regulation of immune response to tumor cell +is_a: GO:0002843 ! regulation of tolerance induction to tumor cell +relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell + +[Term] +id: GO:0002846 +name: regulation of T cell tolerance induction to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +is_a: GO:0002843 ! regulation of tolerance induction to tumor cell +is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction +relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell + +[Term] +id: GO:0002847 +name: negative regulation of T cell tolerance induction to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] +synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] +is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell +is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell +is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell +is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction +relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell + +[Term] +id: GO:0002848 +name: positive regulation of T cell tolerance induction to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] +synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] +synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] +synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] +is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell +is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell +is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell +is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction +relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell + +[Term] +id: GO:0002849 +name: regulation of peripheral T cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002664 ! regulation of T cell tolerance induction +is_a: GO:0002709 ! regulation of T cell mediated immunity +relationship: regulates GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002850 +name: negative regulation of peripheral T cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] +synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] +synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] +is_a: GO:0002659 ! negative regulation of peripheral tolerance induction +is_a: GO:0002665 ! negative regulation of T cell tolerance induction +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction +relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002851 +name: positive regulation of peripheral T cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] +synonym: "activation of peripheral T cell tolerance induction" NARROW [] +synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] +synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] +is_a: GO:0002660 ! positive regulation of peripheral tolerance induction +is_a: GO:0002666 ! positive regulation of T cell tolerance induction +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction +relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002852 +name: regulation of T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002853 +name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] +synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] +is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity +is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell +is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target +relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002854 +name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] +synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity +is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell +is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target +relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002855 +name: regulation of natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0002837 ! regulation of immune response to tumor cell +relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell + +[Term] +id: GO:0002856 +name: negative regulation of natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] +synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] +is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity +is_a: GO:0002838 ! negative regulation of immune response to tumor cell +is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell +relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell + +[Term] +id: GO:0002857 +name: positive regulation of natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] +synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] +synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] +synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] +is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity +is_a: GO:0002839 ! positive regulation of immune response to tumor cell +is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell +relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell + +[Term] +id: GO:0002858 +name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] +is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002859 +name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] +synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] +is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell +is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity +relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002860 +name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] +synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell +is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity +relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002861 +name: regulation of inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] +is_a: GO:0050727 ! regulation of inflammatory response +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus + +[Term] +id: GO:0002862 +name: negative regulation of inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus + +[Term] +id: GO:0002863 +name: positive regulation of inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] +synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] +synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus + +[Term] +id: GO:0002864 +name: regulation of acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002865 +name: negative regulation of acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus +is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus +relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002866 +name: positive regulation of acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] +synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] +synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus +is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus +relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002867 +name: regulation of B cell deletion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] +synonym: "regulation of B lymphocyte deletion" EXACT [] +synonym: "regulation of B-cell deletion" EXACT [] +synonym: "regulation of B-lymphocyte deletion" EXACT [] +is_a: GO:0002661 ! regulation of B cell tolerance induction +is_a: GO:0002902 ! regulation of B cell apoptosis +relationship: regulates GO:0002516 ! B cell deletion + +[Term] +id: GO:0002868 +name: negative regulation of B cell deletion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] +synonym: "down regulation of B cell deletion" EXACT [] +synonym: "down-regulation of B cell deletion" EXACT [] +synonym: "downregulation of B cell deletion" EXACT [] +synonym: "inhibition of B cell deletion" NARROW [] +synonym: "negative regulation of B lymphocyte deletion" EXACT [] +synonym: "negative regulation of B-cell deletion" EXACT [] +synonym: "negative regulation of B-lymphocyte deletion" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002867 ! regulation of B cell deletion +is_a: GO:0002903 ! negative regulation of B cell apoptosis +relationship: negatively_regulates GO:0002516 ! B cell deletion + +[Term] +id: GO:0002869 +name: positive regulation of B cell deletion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] +synonym: "activation of B cell deletion" NARROW [] +synonym: "positive regulation of B lymphocyte deletion" EXACT [] +synonym: "positive regulation of B-cell deletion" EXACT [] +synonym: "positive regulation of B-lymphocyte deletion" EXACT [] +synonym: "stimulation of B cell deletion" NARROW [] +synonym: "up regulation of B cell deletion" EXACT [] +synonym: "up-regulation of B cell deletion" EXACT [] +synonym: "upregulation of B cell deletion" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002867 ! regulation of B cell deletion +is_a: GO:0002904 ! positive regulation of B cell apoptosis +relationship: positively_regulates GO:0002516 ! B cell deletion + +[Term] +id: GO:0002870 +name: T cell anergy +namespace: biological_process +def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte anergy" EXACT [] +synonym: "T-cell anergy" EXACT [] +synonym: "T-lymphocyte anergy" EXACT [] +is_a: GO:0002249 ! lymphocyte anergy +is_a: GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002871 +name: regulation of natural killer cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] +synonym: "regulation of NK cell tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002519 ! natural killer cell tolerance induction + +[Term] +id: GO:0002872 +name: negative regulation of natural killer cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] +synonym: "down regulation of natural killer cell tolerance induction" EXACT [] +synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] +synonym: "downregulation of natural killer cell tolerance induction" EXACT [] +synonym: "inhibition of natural killer cell tolerance induction" NARROW [] +synonym: "negative regulation of NK cell tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002871 ! regulation of natural killer cell tolerance induction +relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction + +[Term] +id: GO:0002873 +name: positive regulation of natural killer cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] +synonym: "activation of natural killer cell tolerance induction" NARROW [] +synonym: "positive regulation of NK cell tolerance induction" EXACT [] +synonym: "stimulation of natural killer cell tolerance induction" NARROW [] +synonym: "up regulation of natural killer cell tolerance induction" EXACT [] +synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] +synonym: "upregulation of natural killer cell tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002871 ! regulation of natural killer cell tolerance induction +relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction + +[Term] +id: GO:0002874 +name: regulation of chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus + +[Term] +id: GO:0002875 +name: negative regulation of chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] +is_a: GO:0002677 ! negative regulation of chronic inflammatory response +is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus +is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus +relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus + +[Term] +id: GO:0002876 +name: positive regulation of chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] +synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] +synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] +is_a: GO:0002678 ! positive regulation of chronic inflammatory response +is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus +is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus +relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus + +[Term] +id: GO:0002877 +name: regulation of acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] +is_a: GO:0002673 ! regulation of acute inflammatory response +relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002878 +name: negative regulation of acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus +relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002879 +name: positive regulation of acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus +relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002880 +name: regulation of chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] +is_a: GO:0002676 ! regulation of chronic inflammatory response +relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002881 +name: negative regulation of chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] +is_a: GO:0002677 ! negative regulation of chronic inflammatory response +is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus +relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002882 +name: positive regulation of chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +is_a: GO:0002678 ! positive regulation of chronic inflammatory response +is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus +relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002883 +name: regulation of hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] +is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus +relationship: regulates GO:0002524 ! hypersensitivity + +[Term] +id: GO:0002884 +name: negative regulation of hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] +synonym: "down regulation of hypersensitivity" EXACT [] +synonym: "down-regulation of hypersensitivity" EXACT [] +synonym: "downregulation of hypersensitivity" EXACT [] +synonym: "inhibition of hypersensitivity" NARROW [] +is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus +is_a: GO:0002883 ! regulation of hypersensitivity +relationship: negatively_regulates GO:0002524 ! hypersensitivity + +[Term] +id: GO:0002885 +name: positive regulation of hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] +synonym: "activation of hypersensitivity" NARROW [] +synonym: "stimulation of hypersensitivity" NARROW [] +synonym: "up regulation of hypersensitivity" EXACT [] +synonym: "up-regulation of hypersensitivity" EXACT [] +synonym: "upregulation of hypersensitivity" EXACT [] +is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus +is_a: GO:0002883 ! regulation of hypersensitivity +relationship: positively_regulates GO:0002524 ! hypersensitivity + +[Term] +id: GO:0002886 +name: regulation of myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002887 +name: negative regulation of myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] +synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] +is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002888 +name: positive regulation of myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] +synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] +synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] +synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] +is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002889 +name: regulation of immunoglobulin mediated immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] +is_a: GO:0002712 ! regulation of B cell mediated immunity +relationship: regulates GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002890 +name: negative regulation of immunoglobulin mediated immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] +synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] +synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002891 +name: positive regulation of immunoglobulin mediated immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] +synonym: "activation of immunoglobulin mediated immune response" NARROW [] +synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] +synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002892 +name: regulation of type II hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] +is_a: GO:0002883 ! regulation of hypersensitivity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0002893 +name: negative regulation of type II hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] +synonym: "down regulation of type II hypersensitivity" EXACT [] +synonym: "down-regulation of type II hypersensitivity" EXACT [] +synonym: "downregulation of type II hypersensitivity" EXACT [] +synonym: "inhibition of type II hypersensitivity" NARROW [] +is_a: GO:0002884 ! negative regulation of hypersensitivity +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: negatively_regulates GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0002894 +name: positive regulation of type II hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] +synonym: "activation of type II hypersensitivity" NARROW [] +synonym: "stimulation of type II hypersensitivity" NARROW [] +synonym: "up regulation of type II hypersensitivity" EXACT [] +synonym: "up-regulation of type II hypersensitivity" EXACT [] +synonym: "upregulation of type II hypersensitivity" EXACT [] +is_a: GO:0002885 ! positive regulation of hypersensitivity +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: positively_regulates GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0002895 +name: regulation of central B cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] +is_a: GO:0002646 ! regulation of central tolerance induction +is_a: GO:0002661 ! regulation of B cell tolerance induction +relationship: regulates GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002896 +name: negative regulation of central B cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] +synonym: "down regulation of central B cell tolerance induction" EXACT [] +synonym: "down-regulation of central B cell tolerance induction" EXACT [] +synonym: "downregulation of central B cell tolerance induction" EXACT [] +synonym: "inhibition of central B cell tolerance induction" NARROW [] +is_a: GO:0002647 ! negative regulation of central tolerance induction +is_a: GO:0002662 ! negative regulation of B cell tolerance induction +is_a: GO:0002895 ! regulation of central B cell tolerance induction +relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002897 +name: positive regulation of central B cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] +synonym: "activation of central B cell tolerance induction" NARROW [] +synonym: "stimulation of central B cell tolerance induction" NARROW [] +synonym: "up regulation of central B cell tolerance induction" EXACT [] +synonym: "up-regulation of central B cell tolerance induction" EXACT [] +synonym: "upregulation of central B cell tolerance induction" EXACT [] +is_a: GO:0002648 ! positive regulation of central tolerance induction +is_a: GO:0002663 ! positive regulation of B cell tolerance induction +is_a: GO:0002895 ! regulation of central B cell tolerance induction +relationship: positively_regulates GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002898 +name: regulation of central B cell deletion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] +is_a: GO:0002867 ! regulation of B cell deletion +is_a: GO:0002895 ! regulation of central B cell tolerance induction +is_a: GO:0045577 ! regulation of B cell differentiation +relationship: regulates GO:0002342 ! central B cell deletion + +[Term] +id: GO:0002899 +name: negative regulation of central B cell deletion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] +synonym: "down regulation of central B cell deletion" EXACT [] +synonym: "down-regulation of central B cell deletion" EXACT [] +synonym: "downregulation of central B cell deletion" EXACT [] +synonym: "inhibition of central B cell deletion" NARROW [] +is_a: GO:0002868 ! negative regulation of B cell deletion +is_a: GO:0002898 ! regulation of central B cell deletion +relationship: negatively_regulates GO:0002342 ! central B cell deletion + +[Term] +id: GO:0002900 +name: positive regulation of central B cell deletion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] +synonym: "activation of central B cell deletion" NARROW [] +synonym: "stimulation of central B cell deletion" NARROW [] +synonym: "up regulation of central B cell deletion" EXACT [] +synonym: "up-regulation of central B cell deletion" EXACT [] +synonym: "upregulation of central B cell deletion" EXACT [] +is_a: GO:0002869 ! positive regulation of B cell deletion +is_a: GO:0002898 ! regulation of central B cell deletion +relationship: positively_regulates GO:0002342 ! central B cell deletion + +[Term] +id: GO:0002901 +name: mature B cell apoptosis +namespace: biological_process +def: "The process of apoptosis in mature B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "apoptosis of mature B cells" EXACT [] +synonym: "apoptosis of mature B lymphocytes" EXACT [] +synonym: "apoptosis of mature B-cells" EXACT [] +synonym: "apoptosis of mature B-lymphocytes" EXACT [] +synonym: "mature B cell programmed cell death by apoptosis" EXACT [] +synonym: "mature B lymphocyte apoptosis" EXACT [] +synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "mature B-cell apoptosis" EXACT [] +synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] +synonym: "mature B-lymphocyte apoptosis" EXACT [] +synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] +synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] +synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death, mature B cells" EXACT [] +synonym: "programmed cell death, mature B lymphocytes" EXACT [] +synonym: "programmed cell death, mature B-cells" EXACT [] +synonym: "programmed cell death, mature B-lymphocytes" EXACT [] +is_a: GO:0001783 ! B cell apoptosis +relationship: part_of GO:0001782 ! B cell homeostasis + +[Term] +id: GO:0002902 +name: regulation of B cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell apoptosis." [GOC:add] +is_a: GO:0042981 ! regulation of apoptosis +relationship: regulates GO:0001783 ! B cell apoptosis + +[Term] +id: GO:0002903 +name: negative regulation of B cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptosis." [GOC:add] +synonym: "down regulation of B cell apoptosis" EXACT [] +synonym: "down-regulation of B cell apoptosis" EXACT [] +synonym: "downregulation of B cell apoptosis" EXACT [] +synonym: "inhibition of B cell apoptosis" NARROW [] +is_a: GO:0002902 ! regulation of B cell apoptosis +is_a: GO:0043066 ! negative regulation of apoptosis +relationship: negatively_regulates GO:0001783 ! B cell apoptosis + +[Term] +id: GO:0002904 +name: positive regulation of B cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptosis." [GOC:add] +synonym: "activation of B cell apoptosis" NARROW [] +synonym: "stimulation of B cell apoptosis" NARROW [] +synonym: "up regulation of B cell apoptosis" EXACT [] +synonym: "up-regulation of B cell apoptosis" EXACT [] +synonym: "upregulation of B cell apoptosis" EXACT [] +is_a: GO:0002902 ! regulation of B cell apoptosis +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: positively_regulates GO:0001783 ! B cell apoptosis + +[Term] +id: GO:0002905 +name: regulation of mature B cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0002902 ! regulation of B cell apoptosis +is_a: GO:0032844 ! regulation of homeostatic process +relationship: regulates GO:0002901 ! mature B cell apoptosis + +[Term] +id: GO:0002906 +name: negative regulation of mature B cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] +synonym: "down regulation of mature B cell apoptosis" EXACT [] +synonym: "down-regulation of mature B cell apoptosis" EXACT [] +synonym: "downregulation of mature B cell apoptosis" EXACT [] +synonym: "inhibition of mature B cell apoptosis" NARROW [] +is_a: GO:0002903 ! negative regulation of B cell apoptosis +is_a: GO:0002905 ! regulation of mature B cell apoptosis +relationship: negatively_regulates GO:0002901 ! mature B cell apoptosis + +[Term] +id: GO:0002907 +name: positive regulation of mature B cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] +synonym: "activation of mature B cell apoptosis" NARROW [] +synonym: "stimulation of mature B cell apoptosis" NARROW [] +synonym: "up regulation of mature B cell apoptosis" EXACT [] +synonym: "up-regulation of mature B cell apoptosis" EXACT [] +synonym: "upregulation of mature B cell apoptosis" EXACT [] +is_a: GO:0002904 ! positive regulation of B cell apoptosis +is_a: GO:0002905 ! regulation of mature B cell apoptosis +relationship: positively_regulates GO:0002901 ! mature B cell apoptosis + +[Term] +id: GO:0002908 +name: regulation of peripheral B cell deletion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002867 ! regulation of B cell deletion +relationship: regulates GO:0002454 ! peripheral B cell deletion + +[Term] +id: GO:0002909 +name: negative regulation of peripheral B cell deletion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] +synonym: "down regulation of peripheral B cell deletion" EXACT [] +synonym: "down-regulation of peripheral B cell deletion" EXACT [] +synonym: "downregulation of peripheral B cell deletion" EXACT [] +synonym: "inhibition of peripheral B cell deletion" NARROW [] +is_a: GO:0002868 ! negative regulation of B cell deletion +is_a: GO:0002908 ! regulation of peripheral B cell deletion +relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion + +[Term] +id: GO:0002910 +name: positive regulation of peripheral B cell deletion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] +synonym: "activation of peripheral B cell deletion" NARROW [] +synonym: "stimulation of peripheral B cell deletion" NARROW [] +synonym: "up regulation of peripheral B cell deletion" EXACT [] +synonym: "up-regulation of peripheral B cell deletion" EXACT [] +synonym: "upregulation of peripheral B cell deletion" EXACT [] +is_a: GO:0002869 ! positive regulation of B cell deletion +is_a: GO:0002908 ! regulation of peripheral B cell deletion +relationship: positively_regulates GO:0002454 ! peripheral B cell deletion + +[Term] +id: GO:0002911 +name: regulation of lymphocyte anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002249 ! lymphocyte anergy + +[Term] +id: GO:0002912 +name: negative regulation of lymphocyte anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] +synonym: "down regulation of lymphocyte anergy" EXACT [] +synonym: "down-regulation of lymphocyte anergy" EXACT [] +synonym: "downregulation of lymphocyte anergy" EXACT [] +synonym: "inhibition of lymphocyte anergy" NARROW [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: negatively_regulates GO:0002249 ! lymphocyte anergy + +[Term] +id: GO:0002913 +name: positive regulation of lymphocyte anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] +synonym: "activation of lymphocyte anergy" NARROW [] +synonym: "stimulation of lymphocyte anergy" NARROW [] +synonym: "up regulation of lymphocyte anergy" EXACT [] +synonym: "up-regulation of lymphocyte anergy" EXACT [] +synonym: "upregulation of lymphocyte anergy" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: positively_regulates GO:0002249 ! lymphocyte anergy + +[Term] +id: GO:0002914 +name: regulation of central B cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002895 ! regulation of central B cell tolerance induction +is_a: GO:0045577 ! regulation of B cell differentiation +relationship: regulates GO:0002341 ! central B cell anergy + +[Term] +id: GO:0002915 +name: negative regulation of central B cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] +synonym: "down regulation of central B cell anergy" EXACT [] +synonym: "down-regulation of central B cell anergy" EXACT [] +synonym: "downregulation of central B cell anergy" EXACT [] +synonym: "inhibition of central B cell anergy" NARROW [] +is_a: GO:0002671 ! negative regulation of B cell anergy +is_a: GO:0002914 ! regulation of central B cell anergy +relationship: negatively_regulates GO:0002341 ! central B cell anergy + +[Term] +id: GO:0002916 +name: positive regulation of central B cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] +synonym: "activation of central B cell anergy" NARROW [] +synonym: "stimulation of central B cell anergy" NARROW [] +synonym: "up regulation of central B cell anergy" EXACT [] +synonym: "up-regulation of central B cell anergy" EXACT [] +synonym: "upregulation of central B cell anergy" EXACT [] +is_a: GO:0002672 ! positive regulation of B cell anergy +is_a: GO:0002914 ! regulation of central B cell anergy +relationship: positively_regulates GO:0002341 ! central B cell anergy + +[Term] +id: GO:0002917 +name: regulation of peripheral B cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002712 ! regulation of B cell mediated immunity +relationship: regulates GO:0002453 ! peripheral B cell anergy + +[Term] +id: GO:0002918 +name: negative regulation of peripheral B cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] +synonym: "down regulation of peripheral B cell anergy" EXACT [] +synonym: "down-regulation of peripheral B cell anergy" EXACT [] +synonym: "downregulation of peripheral B cell anergy" EXACT [] +synonym: "inhibition of peripheral B cell anergy" NARROW [] +is_a: GO:0002671 ! negative regulation of B cell anergy +is_a: GO:0002917 ! regulation of peripheral B cell anergy +relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy + +[Term] +id: GO:0002919 +name: positive regulation of peripheral B cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] +synonym: "activation of peripheral B cell anergy" NARROW [] +synonym: "stimulation of peripheral B cell anergy" NARROW [] +synonym: "up regulation of peripheral B cell anergy" EXACT [] +synonym: "up-regulation of peripheral B cell anergy" EXACT [] +synonym: "upregulation of peripheral B cell anergy" EXACT [] +is_a: GO:0002672 ! positive regulation of B cell anergy +is_a: GO:0002917 ! regulation of peripheral B cell anergy +relationship: positively_regulates GO:0002453 ! peripheral B cell anergy + +[Term] +id: GO:0002920 +name: regulation of humoral immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0006959 ! humoral immune response + +[Term] +id: GO:0002921 +name: negative regulation of humoral immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] +synonym: "down regulation of humoral immune response" EXACT [] +synonym: "down-regulation of humoral immune response" EXACT [] +synonym: "downregulation of humoral immune response" EXACT [] +synonym: "inhibition of humoral immune response" NARROW [] +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0006959 ! humoral immune response + +[Term] +id: GO:0002922 +name: positive regulation of humoral immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] +synonym: "activation of humoral immune response" NARROW [] +synonym: "stimulation of humoral immune response" NARROW [] +synonym: "up regulation of humoral immune response" EXACT [] +synonym: "up-regulation of humoral immune response" EXACT [] +synonym: "upregulation of humoral immune response" EXACT [] +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0006959 ! humoral immune response + +[Term] +id: GO:0002923 +name: regulation of humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +is_a: GO:0002920 ! regulation of humoral immune response +relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0002924 +name: negative regulation of humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] +synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin +relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0002925 +name: positive regulation of humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] +synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] +synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] +synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin +relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0003001 +name: generation of a signal involved in cell-cell signaling +namespace: biological_process +def: "The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] +synonym: "formation of a signal" RELATED [] +synonym: "generation of a signal involved in cell-cell signalling" EXACT [] +synonym: "signal generation" EXACT [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0003002 +name: regionalization +namespace: biological_process +def: "The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0003003 +name: follicular fluid formation in ovarian follicle antrum during fused antrum stage +namespace: biological_process +def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] +is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum +relationship: part_of GO:0048165 ! fused antrum stage, oogenesis + +[Term] +id: GO:0003004 +name: follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage +namespace: biological_process +def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] +is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum +relationship: part_of GO:0048164 ! distinct antral spaces stage, oogenesis + +[Term] +id: GO:0003005 +name: follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage +namespace: biological_process +def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] +is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum +relationship: part_of GO:0048163 ! scattered antral spaces stage, oogenesis + +[Term] +id: GO:0003006 +name: reproductive developmental process +namespace: biological_process +def: "A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] +is_a: GO:0022414 ! reproductive process +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0003007 +name: heart morphogenesis +namespace: biological_process +def: "The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] +synonym: "cardiac morphogenesis" RELATED [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003008 +name: system process +namespace: biological_process +def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] +synonym: "organ system process" EXACT [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0003009 +name: skeletal muscle contraction +namespace: biological_process +def: "A process whereby force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] +is_a: GO:0006941 ! striated muscle contraction +relationship: part_of GO:0050881 ! musculoskeletal movement + +[Term] +id: GO:0003010 +name: voluntary skeletal muscle contraction +namespace: biological_process +def: "A process whereby force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] +is_a: GO:0003009 ! skeletal muscle contraction + +[Term] +id: GO:0003011 +name: involuntary skeletal muscle contraction +namespace: biological_process +def: "A process whereby force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] +is_a: GO:0003009 ! skeletal muscle contraction + +[Term] +id: GO:0003012 +name: muscle system process +namespace: biological_process +def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] +synonym: "muscle physiological process" RELATED [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003013 +name: circulatory system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003014 +name: renal system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism." [GOC:mtg_cardio] +synonym: "kidney system process" RELATED [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003015 +name: heart process +namespace: biological_process +def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] +synonym: "cardiac process" RELATED [] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0003016 +name: respiratory system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:mtg_cardio] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003017 +name: lymph circulation +namespace: biological_process +def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0003018 +name: vascular process in circulatory system +namespace: biological_process +def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] +synonym: "vasculature process" EXACT [] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0003019 +name: central nervous system control of baroreceptor feedback +namespace: biological_process +def: "The neurological process by which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] +is_a: GO:0050877 ! neurological system process +relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback + +[Term] +id: GO:0003020 +name: detection of reduced oxygen by chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] +is_a: GO:0003032 ! detection of oxygen +relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptors + +[Term] +id: GO:0003021 +name: detection of increased carbon dioxide by chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] +is_a: GO:0003031 ! detection of carbon dioxide +relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptors + +[Term] +id: GO:0003022 +name: detection of pH by chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] +is_a: GO:0003030 ! detection of hydrogen ion +relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptors + +[Term] +id: GO:0003023 +name: baroreceptor detection of increased arterial stretch +namespace: biological_process +def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] +is_a: GO:0001981 ! baroreceptor detection of arterial stretch +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0003024 +name: baroreceptor detection of decreased arterial stretch +namespace: biological_process +def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] +is_a: GO:0001981 ! baroreceptor detection of arterial stretch +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0003025 +name: regulation of systemic arterial blood pressure by baroreceptor feedback +namespace: biological_process +def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process + +[Term] +id: GO:0003026 +name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback +namespace: biological_process +def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process +relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback + +[Term] +id: GO:0003027 +name: regulation of systemic arterial blood pressure by carotid body chemoreceptor +namespace: biological_process +def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "vagal reflex" BROAD [] +is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor + +[Term] +id: GO:0003028 +name: regulation of systemic arterial blood pressure by aortic body chemoreceptor +namespace: biological_process +def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor + +[Term] +id: GO:0003029 +name: detection of hypoxic conditions in blood by carotid body chemoreceptors +namespace: biological_process +def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] +is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptors +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor + +[Term] +id: GO:0003030 +name: detection of hydrogen ion +namespace: biological_process +def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0003031 +name: detection of carbon dioxide +namespace: biological_process +def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0003032 +name: detection of oxygen +namespace: biological_process +def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0003033 +name: detection of hypoxic conditions in blood by aortic body chemoreceptors +namespace: biological_process +def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] +is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptors +relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor + +[Term] +id: GO:0003034 +name: detection of increased carbon dioxide by aortic body chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] +is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptors +relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptors + +[Term] +id: GO:0003035 +name: detection of increased carbon dioxide by carotid body chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] +is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptors +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptors + +[Term] +id: GO:0003036 +name: detection of pH by aortic body chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] +is_a: GO:0003022 ! detection of pH by chemoreceptors +relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptors + +[Term] +id: GO:0003037 +name: detection of pH by carotid body chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] +is_a: GO:0003022 ! detection of pH by chemoreceptors +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptors + +[Term] +id: GO:0003038 +name: detection of reduced oxygen by aortic body chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] +is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptors +relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptors + +[Term] +id: GO:0003039 +name: detection of reduced oxygen by carotid body chemoreceptors +namespace: biological_process +def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] +is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptors +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptors + +[Term] +id: GO:0003040 +name: excitation of vasomotor center by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process by which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] +is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling +relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor + +[Term] +id: GO:0003041 +name: excitation of vasomotor center by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process by which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] +is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor + +[Term] +id: GO:0003042 +name: vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951 "Principles of Physiology"] +is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor + +[Term] +id: GO:0003043 +name: vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] +is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure +relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor + +[Term] +id: GO:0003044 +name: regulation of systemic arterial blood pressure mediated by a chemical signal +namespace: biological_process +def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] +synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003045 +name: regulation of systemic arterial blood pressure by physical factors +namespace: biological_process +def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] +synonym: "blood pressure regulation by physical factors" EXACT [] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003046 +name: regulation of systemic arterial blood pressure by stress relaxation +namespace: biological_process +def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "blood pressure regulation by stress relaxation" EXACT [] +is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors +relationship: part_of GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0003047 +name: regulation of systemic arterial blood pressure by epinephrine +namespace: biological_process +def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] +synonym: "blood pressure regulation by epinephrine" RELATED [] +synonym: "regulation of blood pressure by adrenaline" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0003048 +name: regulation of systemic arterial blood pressure by norepinephrine +namespace: biological_process +def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] +synonym: "blood pressure regulation by norepinephrine" RELATED [] +synonym: "regulation of blood pressure by noradrenaline" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0003049 +name: regulation of systemic arterial blood pressure by capillary fluid shift +namespace: biological_process +def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "blood pressure regulation by capillary fluid shift" EXACT [] +is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors + +[Term] +id: GO:0003050 +name: regulation of systemic arterial blood pressure by atrial natriuretic peptide +namespace: biological_process +def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] +synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] +synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003051 +name: angiotensin-mediated drinking behavior +namespace: biological_process +def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] +synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042756 ! drinking behavior +relationship: part_of GO:0002035 ! brain renin-angiotensin system + +[Term] +id: GO:0003052 +name: circadian regulation of systemic arterial blood pressure +namespace: biological_process +def: "Any process by which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0003053 +name: circadian regulation of heart rate +namespace: biological_process +def: "Any process by which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +synonym: "circadian regulation of heart contraction rate" RELATED [] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0003054 +name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus +namespace: biological_process +def: "The process by which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +synonym: "master pacemaker clock regulation of blood pressure" EXACT [] +synonym: "SCN regulation of blood pressure" EXACT [] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process +is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure + +[Term] +id: GO:0003055 +name: circadian regulation of heart rate by the suprachiasmatic nucleus +namespace: biological_process +def: "The process by which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] +synonym: "master pacemaker clock regulation of heart rate" EXACT [] +synonym: "SCN regulation of heart rate" EXACT [] +is_a: GO:0003053 ! circadian regulation of heart rate + +[Term] +id: GO:0003056 +name: regulation of vascular smooth muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0019229 ! regulation of vasoconstriction +relationship: regulates GO:0014829 ! vascular smooth muscle contraction + +[Term] +id: GO:0003057 +name: regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] +synonym: "chemical cardiac inotropy" EXACT [] +synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] +is_a: GO:0002026 ! regulation of the force of heart contraction + +[Term] +id: GO:0003058 +name: hormonal regulation of the force of heart contraction +namespace: biological_process +def: "The process by which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] +synonym: "hormonal cardiac inotropy" EXACT [] +synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] +is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal + +[Term] +id: GO:0003059 +name: positive regulation of the force of heart contraction by epinephrine +namespace: biological_process +def: "The process by which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "adrenaline cardiac inotropy" EXACT [] +synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] +synonym: "epinephrine cardiac inotropy" EXACT [] +synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of heart contraction by adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by epinephrine" RELATED [] +is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003060 +name: negative regulation of the force of heart contraction by acetylcholine +namespace: biological_process +def: "The process by which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "decreased force of heart contraction by acetylcholine" EXACT [] +is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine + +[Term] +id: GO:0003061 +name: positive regulation of the force of heart contraction by norepinephrine +namespace: biological_process +def: "The process by which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] +synonym: "increased force of heart contraction by adrenaline" RELATED [] +synonym: "increased force of heart contraction by norepinephrine" EXACT [] +synonym: "noradrenaline cardiac inotropy" EXACT [] +synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] +synonym: "norepinephrine cardiac inotropy" EXACT [] +synonym: "positive regulation of heart contraction by adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] +is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003062 +name: regulation of heart rate by chemical signal +namespace: biological_process +def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] +synonym: "chemical cardiac chronotropy" EXACT [] +synonym: "chemical signal regulation of heart contraction rate" RELATED [] +synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002027 ! regulation of heart rate + +[Term] +id: GO:0003063 +name: negative regulation of heart rate by acetylcholine +namespace: biological_process +def: "The process by which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal +relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine + +[Term] +id: GO:0003064 +name: regulation of the rate of heart contraction by hormone +namespace: biological_process +def: "The process by which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] +synonym: "hormonal cardiac chronotropy" EXACT [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal + +[Term] +id: GO:0003065 +name: positive regulation of heart rate by epinephrine +namespace: biological_process +def: "The process by which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "adrenaline cardiac chronotropy" EXACT [] +synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] +synonym: "epinephrine cardiac chronotropy" EXACT [] +synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] +synonym: "positive regulation of heart rate by adrenaline" RELATED [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine + +[Term] +id: GO:0003066 +name: positive regulation of heart rate by norepinephrine +namespace: biological_process +def: "The process by which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "noradrenaline cardiac chronotropy" EXACT [] +synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] +synonym: "norepinephrine cardiac chronotropy" EXACT [] +synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] +synonym: "positive regulation of heart rate by adrenaline" EXACT [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine + +[Term] +id: GO:0003067 +name: circadian regulation of systemic arterial blood pressure by hormone +namespace: biological_process +def: "The process by which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone +relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure + +[Term] +id: GO:0003068 +name: regulation of systemic arterial blood pressure by acetylcholine +namespace: biological_process +def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] +synonym: "blood pressure regulation by acetylcholine" EXACT [] +is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter + +[Term] +id: GO:0003069 +name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process by which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine +relationship: part_of GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0003070 +name: regulation of systemic arterial blood pressure by neurotransmitter +namespace: biological_process +def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio, http://cancerweb.ncl.ac.uk] +is_a: GO:0001976 ! regulation of systemic arterial blood pressure by neurological process +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal + +[Term] +id: GO:0003071 +name: regulation of systemic arterial blood pressure by renal system process +namespace: biological_process +def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "renal control of blood pressure" EXACT [] +synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003014 ! renal system process +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003072 +name: regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence +namespace: biological_process +def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] +synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003071 ! regulation of systemic arterial blood pressure by renal system process + +[Term] +id: GO:0003073 +name: regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0003074 +name: regulation of diuresis +namespace: biological_process +def: "Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0030146 ! diuresis + +[Term] +id: GO:0003075 +name: regulation of systemic arterial blood pressure by renal vasodilation of the peripheral vascular system +namespace: biological_process +def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] +synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003071 ! regulation of systemic arterial blood pressure by renal system process +relationship: part_of GO:0003072 ! regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence + +[Term] +id: GO:0003077 +name: negative regulation of diuresis +namespace: biological_process +def: "Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] +is_a: GO:0003074 ! regulation of diuresis +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0030146 ! diuresis + +[Term] +id: GO:0003078 +name: regulation of natriuresis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0030147 ! natriuresis + +[Term] +id: GO:0003079 +name: positive regulation of natriuresis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] +is_a: GO:0003078 ! regulation of natriuresis +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0030147 ! natriuresis + +[Term] +id: GO:0003080 +name: negative regulation of natriuresis +namespace: biological_process +def: "Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] +is_a: GO:0003078 ! regulation of natriuresis +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0030147 ! natriuresis + +[Term] +id: GO:0003081 +name: regulation of systemic arterial blood pressure by renin-angiotensin +namespace: biological_process +def: "The process by which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] +synonym: "blood pressure regulation by renin-angiotensin" EXACT [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003082 +name: positive regulation of renal output by angiotensin +namespace: biological_process +def: "The process by which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002019 ! regulation of renal output by angiotensin +is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0003083 +name: negative regulation of renal output by angiotensin +namespace: biological_process +def: "The process by which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002019 ! regulation of renal output by angiotensin +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0003084 +name: positive regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] +is_a: GO:0045777 ! positive regulation of blood pressure +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003085 +name: negative regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] +is_a: GO:0045776 ! negative regulation of blood pressure +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003086 +name: regulation of systemic arterial blood pressure by local renal renin-angiotensin +namespace: biological_process +def: "The process by which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin + +[Term] +id: GO:0003087 +name: positive regulation of the force of heart contraction by neuronal epinephrine +namespace: biological_process +def: "The process by which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] +synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] +synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of heart contraction by adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] +is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine +relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine + +[Term] +id: GO:0003088 +name: positive regulation of the force of heart contraction by circulating epinephrine +namespace: biological_process +def: "The process by which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] +synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] +synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] +is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine +relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine + +[Term] +id: GO:0003089 +name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] +synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] +synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] +synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] +is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003090 +name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] +synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] +synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] +synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] +is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003091 +name: renal water homeostasis +namespace: biological_process +def: "Renal process involved in the maintenance of internal equilibrium of water in the body." [GOC:mtg_cardio] +is_a: GO:0003014 ! renal system process +is_a: GO:0050891 ! multicellular organismal water homeostasis + +[Term] +id: GO:0003092 +name: renal water retention +namespace: biological_process +def: "The process whereby renal water excretion is decreased." [GOC:mtg_cardio] +synonym: "negative regulation of renal water excretion" EXACT [] +is_a: GO:0003077 ! negative regulation of diuresis + +[Term] +id: GO:0003093 +name: regulation of glomerular filtration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] +is_a: GO:0001977 ! regulation of blood volume by renal system process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0003094 ! glomerular filtration + +[Term] +id: GO:0003094 +name: glomerular filtration +namespace: biological_process +def: "The process whereby plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +is_a: GO:0003014 ! renal system process + +[Term] +id: GO:0003095 +name: pressure natriuresis +namespace: biological_process +def: "The process by which the volume of blood increases renal pressure and results in an increase in natriuresis and diuresis." [GOC:mtg_cardio] +is_a: GO:0001977 ! regulation of blood volume by renal system process + +[Term] +id: GO:0003096 +name: renal sodium ion transport +namespace: biological_process +def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] +is_a: GO:0003014 ! renal system process +is_a: GO:0006814 ! sodium ion transport +relationship: part_of GO:0001977 ! regulation of blood volume by renal system process + +[Term] +id: GO:0003097 +name: renal water transport +namespace: biological_process +def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio] +is_a: GO:0003014 ! renal system process +is_a: GO:0006833 ! water transport +relationship: part_of GO:0001977 ! regulation of blood volume by renal system process + +[Term] +id: GO:0003098 +name: tubuloglomerular feedback +namespace: biological_process +def: "The process by which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] +is_a: GO:0001977 ! regulation of blood volume by renal system process +relationship: part_of GO:0003093 ! regulation of glomerular filtration + +[Term] +id: GO:0003099 +name: positive regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] +synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] +is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal +is_a: GO:0045823 ! positive regulation of heart contraction + +[Term] +id: GO:0003100 +name: regulation of systemic arterial blood pressure by endothelin +namespace: biological_process +def: "The process by which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003101 +name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine +namespace: biological_process +def: "The process by which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] +synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003102 +name: positive regulation of diuresis by angiotensin +namespace: biological_process +def: "Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003103 ! positive regulation of diuresis +relationship: part_of GO:0003082 ! positive regulation of renal output by angiotensin + +[Term] +id: GO:0003103 +name: positive regulation of diuresis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] +is_a: GO:0003074 ! regulation of diuresis +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0030146 ! diuresis + +[Term] +id: GO:0003104 +name: positive regulation of glomerular filtration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] +is_a: GO:0003093 ! regulation of glomerular filtration +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0003094 ! glomerular filtration + +[Term] +id: GO:0003105 +name: negative regulation of glomerular filtration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] +is_a: GO:0003093 ! regulation of glomerular filtration +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0003094 ! glomerular filtration + +[Term] +id: GO:0003106 +name: regulation of glomerular filtration by angiotensin +namespace: biological_process +def: "The process by which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] +synonym: "angiotensin-mediated regulation of glomerular filtration" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003083 ! negative regulation of renal output by angiotensin +relationship: part_of GO:0003105 ! negative regulation of glomerular filtration + +[Term] +id: GO:0003107 +name: positive regulation of natriuresis by angiotensin +namespace: biological_process +def: "The process by which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003079 ! positive regulation of natriuresis +relationship: part_of GO:0003102 ! positive regulation of diuresis by angiotensin + +[Term] +id: GO:0003108 +name: negative regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] +synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] +is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal +is_a: GO:0045822 ! negative regulation of heart contraction + +[Term] +id: GO:0003109 +name: positive regulation of the force of heart contraction by circulating norepinephrine +namespace: biological_process +def: "The process by which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] +synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine + +[Term] +id: GO:0003110 +name: positive regulation of the force of heart contraction by neuronal norepinephrine +namespace: biological_process +def: "The process by which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] +synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine + +[Term] +id: GO:0003111 +name: positive regulation of heart rate by circulating epinephrine +namespace: biological_process +def: "The process by which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] +is_a: GO:0003065 ! positive regulation of heart rate by epinephrine + +[Term] +id: GO:0003112 +name: positive regulation of heart rate by neuronal epinephrine +namespace: biological_process +def: "The process by which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] +is_a: GO:0003065 ! positive regulation of heart rate by epinephrine + +[Term] +id: GO:0003113 +name: positive regulation of heart rate by neuronal norepinephrine +namespace: biological_process +def: "The process by which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] +is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine + +[Term] +id: GO:0003114 +name: positive regulation of heart rate by circulating norepinephrine +namespace: biological_process +def: "The process by which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] +is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine + +[Term] +id: GO:0003115 +name: regulation of vasoconstriction by epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +is_a: GO:0019229 ! regulation of vasoconstriction + +[Term] +id: GO:0003116 +name: regulation of vasoconstriction by norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +is_a: GO:0019229 ! regulation of vasoconstriction + +[Term] +id: GO:0003117 +name: regulation of vasoconstriction by circulating norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] +is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine + +[Term] +id: GO:0003118 +name: regulation of vasoconstriction by neuronal norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] +is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine + +[Term] +id: GO:0003119 +name: regulation of vasoconstriction by neuronal epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] +is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine + +[Term] +id: GO:0003120 +name: regulation of vasoconstriction by circulating epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] +is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine + +[Term] +id: GO:0003121 +name: regulation of vasodilation by epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by adrenaline" EXACT [] +is_a: GO:0042312 ! regulation of vasodilation + +[Term] +id: GO:0003122 +name: regulation of vasodilation by norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by noradrenaline" EXACT [] +is_a: GO:0042312 ! regulation of vasodilation + +[Term] +id: GO:0003123 +name: regulation of vasodilation by circulating epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by circulating adrenaline" EXACT [] +is_a: GO:0003121 ! regulation of vasodilation by epinephrine + +[Term] +id: GO:0003124 +name: regulation of vasodilation by neuronal epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by neuronal adrenaline" EXACT [] +is_a: GO:0003121 ! regulation of vasodilation by epinephrine + +[Term] +id: GO:0003125 +name: regulation of vasodilation by circulating norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by circulating noradrenaline" EXACT [] +is_a: GO:0003122 ! regulation of vasodilation by norepinephrine + +[Term] +id: GO:0003126 +name: regulation of vasodilation by neuronal norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT [] +is_a: GO:0003122 ! regulation of vasodilation by norepinephrine + +[Term] +id: GO:0003673 +name: Gene_Ontology +namespace: biological_process +def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +is_obsolete: true + +[Term] +id: GO:0003674 +name: molecular_function +namespace: molecular_function +alt_id: GO:0005554 +def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] +comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "molecular function" EXACT [] +synonym: "molecular function unknown" NARROW [] + +[Term] +id: GO:0003675 +name: protein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0003676 +name: nucleic acid binding +namespace: molecular_function +def: "Interacting selectively with any nucleic acid." [GOC:jl] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0003677 +name: DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA (deoxyribonucleic acid)." [GOC:jl] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "microtubule/chromatin interaction" RELATED [] +synonym: "plasmid binding" NARROW [] +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0003678 +name: DNA helicase activity +namespace: molecular_function +alt_id: GO:0003679 +def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] +comment: Consider also annotating to the molecular function term 'DNA binding ; GO:0003677'. +subset: gosubset_prok +is_a: GO:0004386 ! helicase activity + +[Term] +id: GO:0003680 +name: AT DNA binding +namespace: molecular_function +def: "Interacting selectively with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, UniProtKB:P13483] +synonym: "AT binding" EXACT [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0003681 +name: bent DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA in a bent conformation." [GOC:jl, PMID:12627977] +subset: gosubset_prok +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0003682 +name: chromatin binding +namespace: molecular_function +def: "Interacting selectively with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +synonym: "lamin/chromatin binding" BROAD [] +synonym: "microtubule/chromatin interaction" RELATED [] +synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0003683 +name: lamin/chromatin binding +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents two functions. +is_obsolete: true +replaced_by: GO:0003682 +replaced_by: GO:0005521 + +[Term] +id: GO:0003684 +name: damaged DNA binding +namespace: molecular_function +def: "Interacting selectively with damaged DNA." [GOC:jl] +subset: gosubset_prok +synonym: "DNA repair enzyme" RELATED [] +synonym: "DNA repair protein" RELATED [] +xref: Reactome:7372 +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0003685 +name: DNA repair protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it includes a process term. +is_obsolete: true +consider: GO:0003684 + +[Term] +id: GO:0003686 +name: DNA repair enzyme +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it includes a process term. +is_obsolete: true +consider: GO:0003684 + +[Term] +id: GO:0003687 +name: DNA replication factor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +is_obsolete: true +consider: GO:0006260 + +[Term] +id: GO:0003688 +name: DNA replication origin binding +namespace: molecular_function +def: "Interacting selectively with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "ARS binding" NARROW [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0003689 +name: DNA clamp loader activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] +subset: gosubset_prok +synonym: "DNA clamp loading ATPase activity" EXACT [] +synonym: "PCNA loading activity" NARROW [] +synonym: "PCNA loading complex activity" NARROW [] +xref: Reactome:9823 +is_a: GO:0003677 ! DNA binding +is_a: GO:0033170 ! DNA-protein loading ATPase activity + +[Term] +id: GO:0003690 +name: double-stranded DNA binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA." [GOC:elh] +subset: gosubset_prok +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0003691 +name: double-stranded telomeric DNA binding +namespace: molecular_function +def: "Interacting selectively with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] +is_a: GO:0003690 ! double-stranded DNA binding +is_a: GO:0042162 ! telomeric DNA binding + +[Term] +id: GO:0003692 +name: left-handed Z-DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0003693 +name: P-element binding +namespace: molecular_function +def: "Interacting selectively with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0003694 +name: plasmid binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it refers to component information. +synonym: "plasmid-associated protein" RELATED [] +is_obsolete: true +consider: GO:0003677 +consider: GO:0005727 + +[Term] +id: GO:0003695 +name: random coil DNA binding +namespace: molecular_function +alt_id: GO:0016017 +def: "Interacting selectively with DNA in a random coil configuration." [GOC:mah] +synonym: "random coil binding" EXACT [] +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0003696 +name: satellite DNA binding +namespace: molecular_function +def: "Interacting selectively with satellite DNA, DNA containing highly repetitive sequences which makes up a large proportion of the eukaryotic genome." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0003697 +name: single-stranded DNA binding +namespace: molecular_function +alt_id: GO:0003698 +alt_id: GO:0003699 +def: "Interacting selectively with single-stranded DNA." [GOC:elh] +subset: gosubset_prok +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0003700 +name: transcription factor activity +namespace: molecular_function +alt_id: GO:0000130 +def: "The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0003677 ! DNA binding +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003701 +name: RNA polymerase I transcription factor activity +namespace: molecular_function +def: "Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003702 +name: RNA polymerase II transcription factor activity +namespace: molecular_function +def: "Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003704 +name: specific RNA polymerase II transcription factor activity +namespace: molecular_function +def: "Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] +is_a: GO:0003702 ! RNA polymerase II transcription factor activity + +[Term] +id: GO:0003705 +name: RNA polymerase II transcription factor activity, enhancer binding +namespace: molecular_function +def: "Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA." [GOC:jl] +is_a: GO:0003700 ! transcription factor activity +is_a: GO:0003702 ! RNA polymerase II transcription factor activity + +[Term] +id: GO:0003706 +name: ligand-regulated transcription factor activity +namespace: molecular_function +is_a: GO:0003704 ! specific RNA polymerase II transcription factor activity + +[Term] +id: GO:0003707 +name: steroid hormone receptor activity +namespace: molecular_function +def: "Combining with a steroid hormone to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0004879 ! ligand-dependent nuclear receptor activity + +[Term] +id: GO:0003708 +name: retinoic acid receptor activity +namespace: molecular_function +def: "Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +synonym: "vitamin A receptor activity" BROAD [] +is_a: GO:0004879 ! ligand-dependent nuclear receptor activity + +[Term] +id: GO:0003709 +name: RNA polymerase III transcription factor activity +namespace: molecular_function +def: "Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003711 +name: transcription elongation regulator activity +namespace: molecular_function +def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] +subset: gosubset_prok +synonym: "transcription elongation factor activity" EXACT [] +synonym: "transcriptional elongation regulator activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003712 +name: transcription cofactor activity +namespace: molecular_function +def: "The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself." [PMID:10213677] +subset: gosubset_prok +synonym: "transcriptional co-regulator" EXACT [] +synonym: "transcriptional cofactor activity" EXACT [] +is_a: GO:0008134 ! transcription factor binding +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003713 +name: transcription coactivator activity +namespace: molecular_function +def: "The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma] +subset: gosubset_prok +synonym: "transcription co-activator activity" EXACT [] +is_a: GO:0003712 ! transcription cofactor activity +is_a: GO:0016563 ! transcription activator activity + +[Term] +id: GO:0003714 +name: transcription corepressor activity +namespace: molecular_function +def: "The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma] +synonym: "transcription co-repressor activity" EXACT [] +is_a: GO:0003712 ! transcription cofactor activity +is_a: GO:0016564 ! transcription repressor activity + +[Term] +id: GO:0003715 +name: transcription termination factor activity +namespace: molecular_function +def: "Any activity that brings about termination of transcription." [GOC:mah] +subset: gosubset_prok +synonym: "transcriptional termination factor activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0003716 +name: RNA polymerase I transcription termination factor activity +namespace: molecular_function +def: "Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] +synonym: "Pol I transcription termination factor activity" EXACT [] +is_a: GO:0003715 ! transcription termination factor activity + +[Term] +id: GO:0003717 +name: RNA polymerase II transcription termination factor activity +namespace: molecular_function +def: "Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] +synonym: "Pol II transcription termination factor activity" EXACT [] +is_a: GO:0003715 ! transcription termination factor activity + +[Term] +id: GO:0003718 +name: RNA polymerase III transcription termination factor activity +namespace: molecular_function +def: "Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] +synonym: "Pol III transcription termination factor activity" EXACT [] +is_a: GO:0003715 ! transcription termination factor activity + +[Term] +id: GO:0003719 +name: transcription factor binding, cytoplasmic sequestering +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because sequestering is a process rather than a function. +is_obsolete: true +replaced_by: GO:0042994 + +[Term] +id: GO:0003720 +name: telomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] +comment: Consider also annotating to the molecular function term 'telomeric DNA binding ; GO:0042162'. +xref: EC:2.7.7.- +xref: Reactome:10567 +is_a: GO:0003964 ! RNA-directed DNA polymerase activity + +[Term] +id: GO:0003721 +name: telomeric template RNA reverse transcriptase activity +namespace: molecular_function +def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] +synonym: "telomerase, catalyst" EXACT [] +is_a: GO:0003964 ! RNA-directed DNA polymerase activity +relationship: part_of GO:0003720 ! telomerase activity + +[Term] +id: GO:0003723 +name: RNA binding +namespace: molecular_function +def: "Interacting selectively with an RNA molecule or a portion thereof." [GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0003724 +name: RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] +comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'. +subset: gosubset_prok +xref: EC:2.7.7.- +xref: Reactome:7008 +is_a: GO:0004386 ! helicase activity + +[Term] +id: GO:0003725 +name: double-stranded RNA binding +namespace: molecular_function +def: "Interacting selectively with double-stranded RNA." [GOC:jl] +subset: gosubset_prok +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0003726 +name: double-stranded RNA adenosine deaminase activity +namespace: molecular_function +alt_id: GO:0003971 +def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] +subset: gosubset_prok +synonym: "double-stranded RNA specific editase activity" RELATED [] +xref: Reactome:10576 +is_a: GO:0004000 ! adenosine deaminase activity + +[Term] +id: GO:0003727 +name: single-stranded RNA binding +namespace: molecular_function +alt_id: GO:0003728 +def: "Interacting selectively with single-stranded RNA." [GOC:jl] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0003729 +name: mRNA binding +namespace: molecular_function +def: "Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA)." [GOC:jl] +subset: gosubset_prok +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0003730 +name: mRNA 3'-UTR binding +namespace: molecular_function +def: "Interacting selectively with the 3' untranslated region of an mRNA molecule." [GOC:mah] +synonym: "mRNA 3' UTR binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0003731 +name: mRNA cap binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] +comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. +is_obsolete: true +consider: GO:0000339 + +[Term] +id: GO:0003732 +name: snRNA cap binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] +comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. +is_obsolete: true +consider: GO:0000339 + +[Term] +id: GO:0003733 +name: ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +is_obsolete: true +replaced_by: GO:0030529 + +[Term] +id: GO:0003734 +name: small nuclear ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "snRNP" EXACT [] +is_obsolete: true +replaced_by: GO:0030532 + +[Term] +id: GO:0003735 +name: structural constituent of ribosome +namespace: molecular_function +alt_id: GO:0003736 +alt_id: GO:0003737 +alt_id: GO:0003738 +alt_id: GO:0003739 +alt_id: GO:0003740 +alt_id: GO:0003741 +alt_id: GO:0003742 +def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] +comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. +subset: gosubset_prok +synonym: "ribosomal protein" BROAD [] +synonym: "ribosomal RNA" RELATED [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0003743 +name: translation initiation factor activity +namespace: molecular_function +alt_id: GO:0003744 +alt_id: GO:0003745 +def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: Reactome:10611 +is_a: GO:0008135 ! translation factor activity, nucleic acid binding + +[Term] +id: GO:0003746 +name: translation elongation factor activity +namespace: molecular_function +alt_id: GO:0008182 +alt_id: GO:0008183 +def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: Reactome:10616 +is_a: GO:0008135 ! translation factor activity, nucleic acid binding + +[Term] +id: GO:0003747 +name: translation release factor activity +namespace: molecular_function +alt_id: GO:0003748 +alt_id: GO:0003749 +def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0008079 ! translation termination factor activity + +[Term] +id: GO:0003750 +name: cell cycle regulator +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it does not represent a single molecular function. +is_obsolete: true +replaced_by: GO:0051726 + +[Term] +id: GO:0003754 +name: chaperone activity +namespace: molecular_function +alt_id: GO:0003757 +alt_id: GO:0003758 +alt_id: GO:0003760 +alt_id: GO:0003761 +def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] +comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 + +[Term] +id: GO:0003755 +name: peptidyl-prolyl cis-trans isomerase activity +namespace: molecular_function +alt_id: GO:0004752 +def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] +subset: gosubset_prok +synonym: "cis-trans proline isomerase activity" EXACT [] +synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] +synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] +synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] +synonym: "immunophilin" RELATED [] +synonym: "parvulin" RELATED [] +synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] +synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] +synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] +synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] +synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] +synonym: "PPIase activity" EXACT [EC:5.2.1.8] +synonym: "rotamase activity" EXACT [EC:5.2.1.8] +xref: EC:5.2.1.8 +xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0003756 +name: protein disulfide isomerase activity +namespace: molecular_function +def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] +subset: gosubset_prok +synonym: "protein cysteine-thiol oxidation" RELATED [] +synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] +synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] +synonym: "protein disulphide isomerase activity" EXACT [] +synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] +xref: EC:5.3.4.1 +xref: MetaCyc:5.3.4.1-RXN +xref: MetaCyc:DISULISOM-RXN +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups +is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds + +[Term] +id: GO:0003759 +name: glycoprotein-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] +comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 + +[Term] +id: GO:0003762 +name: histone-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] +comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. +synonym: "nucleosome assembly chaperone" EXACT [] +is_obsolete: true +consider: GO:0006333 +consider: GO:0006334 +consider: GO:0042393 +consider: GO:0051082 + +[Term] +id: GO:0003763 +name: chaperonin ATPase activity +namespace: molecular_function +alt_id: GO:0003764 +alt_id: GO:0003765 +alt_id: GO:0003766 +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +synonym: "chaperonin" EXACT [] +is_obsolete: true +replaced_by: GO:0042623 +consider: GO:0006457 + +[Term] +id: GO:0003767 +name: co-chaperone activity +namespace: molecular_function +alt_id: GO:0003768 +alt_id: GO:0003769 +alt_id: GO:0003770 +alt_id: GO:0003771 +def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] +comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. +is_obsolete: true +consider: GO:0006457 +consider: GO:0051087 + +[Term] +id: GO:0003772 +name: co-chaperonin activity +namespace: molecular_function +def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] +comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. +is_obsolete: true +consider: GO:0006457 +consider: GO:0051087 + +[Term] +id: GO:0003773 +name: heat shock protein activity +namespace: molecular_function +def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] +comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. +is_obsolete: true +consider: GO:0006986 +consider: GO:0042026 + +[Term] +id: GO:0003774 +name: motor activity +namespace: molecular_function +def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0003775 +name: axonemal motor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes cellular component information. +is_obsolete: true +consider: GO:0003777 +consider: GO:0005930 + +[Term] +id: GO:0003776 +name: muscle motor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes anatomy information. +is_obsolete: true +replaced_by: GO:0000146 +consider: GO:0006936 +consider: GO:0043292 + +[Term] +id: GO:0003777 +name: microtubule motor activity +namespace: molecular_function +def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] +comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. +synonym: "axonemal motor activity" NARROW [] +synonym: "dynein" BROAD [] +synonym: "dynein ATPase activity" NARROW [] +synonym: "kinesin" BROAD [] +synonym: "kinesin motor activity" NARROW [] +synonym: "kinetochore motor activity" NARROW [] +is_a: GO:0003774 ! motor activity + +[Term] +id: GO:0003778 +name: dynactin motor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] +comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. +is_obsolete: true + +[Term] +id: GO:0003779 +name: actin binding +namespace: molecular_function +def: "Interacting selectively with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] +subset: goslim_generic +synonym: "membrane associated actin binding" NARROW [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0003780 +name: actin cross-linking activity +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jic] +comment: This term was made obsolete because it represents a combination of molecular functions. +is_obsolete: true +replaced_by: GO:0030674 +replaced_by: GO:0051015 + +[Term] +id: GO:0003781 +name: actin bundling activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0051017 + +[Term] +id: GO:0003782 +name: F-actin capping activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true +replaced_by: GO:0051016 + +[Term] +id: GO:0003783 +name: barbed-end actin capping activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true +replaced_by: GO:0051016 + +[Term] +id: GO:0003784 +name: barbed-end actin capping/severing activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes two biological processes. +is_obsolete: true +replaced_by: GO:0051014 +replaced_by: GO:0051016 + +[Term] +id: GO:0003785 +name: actin monomer binding +namespace: molecular_function +def: "Interacting selectively with monomeric actin, also known as G-actin." [GOC:ai] +synonym: "G actin binding" EXACT [] +is_a: GO:0003779 ! actin binding + +[Term] +id: GO:0003786 +name: actin lateral binding +namespace: molecular_function +def: "Interacting selectively with an actin filament along its length." [GOC:mah] +is_a: GO:0051015 ! actin filament binding + +[Term] +id: GO:0003787 +name: actin depolymerizing activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0030042 + +[Term] +id: GO:0003788 +name: actin monomer sequestering activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because sequestering is a process, not an activity. +is_obsolete: true +replaced_by: GO:0042989 + +[Term] +id: GO:0003789 +name: actin filament severing activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true +replaced_by: GO:0051014 + +[Term] +id: GO:0003790 +name: actin modulating activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not make sense. +is_obsolete: true +consider: GO:0030036 + +[Term] +id: GO:0003791 +name: membrane associated actin binding +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0003779 +consider: GO:0016020 + +[Term] +id: GO:0003792 +name: regulation of actin thin filament length activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the concept belongs in the process ontology. +is_obsolete: true +replaced_by: GO:0030832 + +[Term] +id: GO:0003793 +name: defense/immunity protein activity +namespace: molecular_function +def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] +comment: This term was made obsolete because it refers to involvement in a biological process. +synonym: "defence/immunity protein activity" EXACT [] +is_obsolete: true +consider: GO:0006952 + +[Term] +id: GO:0003794 +name: acute-phase response protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to involvement in a biological process. +is_obsolete: true +consider: GO:0006953 + +[Term] +id: GO:0003795 +name: antimicrobial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +is_obsolete: true +consider: GO:0006952 + +[Term] +id: GO:0003796 +name: lysozyme activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] +subset: gosubset_prok +synonym: "1,4-N-acetylmuramidase activity" EXACT [] +synonym: "globulin G" RELATED [EC:3.2.1.17] +synonym: "globulin G1" RELATED [EC:3.2.1.17] +synonym: "L-7001" RELATED [EC:3.2.1.17] +synonym: "lysozyme g" RELATED [EC:3.2.1.17] +synonym: "mucopeptide glucohydrolase activity" EXACT [] +synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] +synonym: "muramidase activity" EXACT [] +synonym: "N,O-diacetylmuramidase activity" EXACT [] +synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] +synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] +xref: EC:3.2.1.17 +xref: MetaCyc:3.2.1.17-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0003797 +name: antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +is_obsolete: true +consider: GO:0042742 + +[Term] +id: GO:0003798 +name: male-specific antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +is_obsolete: true +consider: GO:0050831 + +[Term] +id: GO:0003799 +name: antifungal peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +is_obsolete: true +consider: GO:0050832 + +[Term] +id: GO:0003800 +name: antiviral response protein activity +namespace: molecular_function +def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] +comment: This term was made obsolete because it refers to involvement in a biological process. +is_obsolete: true +consider: GO:0009615 + +[Term] +id: GO:0003801 +name: blood coagulation factor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to involvement in a biological process. +is_obsolete: true +consider: GO:0004252 +consider: GO:0007596 + +[Term] +id: GO:0003802 +name: coagulation factor VIIa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] +synonym: "blood coagulation factor VII activity" EXACT [] +synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] +xref: EC:3.4.21.21 +xref: MetaCyc:3.4.21.21-RXN +xref: Reactome:11520 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003803 +name: coagulation factor IXa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] +synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] +synonym: "activated christmas factor" RELATED [EC:3.4.21.22] +synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] +synonym: "blood coagulation factor IX activity" EXACT [] +synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] +synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] +synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] +xref: EC:3.4.21.22 +xref: MetaCyc:3.4.21.22-RXN +xref: Reactome:11522 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003804 +name: coagulation factor Xa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] +synonym: "activated factor X" RELATED [EC:3.4.21.6] +synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] +synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] +synonym: "blood coagulation factor X activity" EXACT [] +synonym: "factor Xa" RELATED [EC:3.4.21.6] +synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] +synonym: "prothrombase activity" EXACT [EC:3.4.21.6] +synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] +synonym: "Stuart factor" RELATED [EC:3.4.21.6] +synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] +synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] +synonym: "thromboplastin" RELATED [EC:3.4.21.6] +xref: EC:3.4.21.6 +xref: MetaCyc:3.4.21.6-RXN +xref: Reactome:11523 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003805 +name: coagulation factor XIa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] +synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] +synonym: "blood coagulation factor XI activity" EXACT [] +synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] +synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] +xref: EC:3.4.21.27 +xref: MetaCyc:3.4.21.27-RXN +xref: Reactome:11530 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003806 +name: coagulation factor XIIa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] +synonym: "blood coagulation factor XII activity" EXACT [] +synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] +synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] +synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] +synonym: "hageman factor activity" EXACT [EC:3.4.21.38] +synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] +synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] +synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] +synonym: "prealbumin activator" RELATED [EC:3.4.21.38] +synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] +xref: EC:3.4.21.38 +xref: MetaCyc:3.4.21.38-RXN +xref: Reactome:11532 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003807 +name: plasma kallikrein activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] +comment: This term was made obsolete because it represents a gene product. +synonym: "bradykininogenase" BROAD [EC:3.4.21.34] +synonym: "callicrein" RELATED [EC:3.4.21.34] +synonym: "depot-padutin" RELATED [EC:3.4.21.34] +synonym: "dilminal D" RELATED [EC:3.4.21.34] +synonym: "glumorin" RELATED [EC:3.4.21.34] +synonym: "kallidinogenase" BROAD [EC:3.4.21.34] +synonym: "kallikrein" RELATED [EC:3.4.21.34] +synonym: "kallikrein I" RELATED [EC:3.4.21.34] +synonym: "kallikrein II" RELATED [EC:3.4.21.34] +synonym: "kininogenase" BROAD [EC:3.4.21.34] +synonym: "kininogenin activity" RELATED [EC:3.4.21.34] +synonym: "onokrein P" RELATED [EC:3.4.21.34] +synonym: "padreatin" RELATED [EC:3.4.21.34] +synonym: "padutin" RELATED [EC:3.4.21.34] +synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] +synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] +synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] +synonym: "urokallikrein" RELATED [EC:3.4.21.34] +xref: EC:3.4.21.34 +xref: MetaCyc:3.4.21.34-RXN +xref: Reactome:11535 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003808 +name: protein C (activated) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] +synonym: "activated protein C" RELATED [EC:3.4.21.69] +synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] +synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] +synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] +synonym: "GSAPC" RELATED [EC:3.4.21.69] +synonym: "protein Ca" RELATED [EC:3.4.21.69] +xref: EC:3.4.21.69 +xref: MetaCyc:3.4.21.69-RXN +xref: Reactome:11537 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003809 +name: thrombin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] +synonym: "beta-thrombin" RELATED [EC:3.4.21.5] +synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] +synonym: "E thrombin" RELATED [EC:3.4.21.5] +synonym: "factor IIa" RELATED [EC:3.4.21.5] +synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] +synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] +synonym: "thrombase activity" EXACT [EC:3.4.21.5] +synonym: "thrombin-C" RELATED [EC:3.4.21.5] +synonym: "thrombofort" RELATED [EC:3.4.21.5] +synonym: "topical" RELATED [EC:3.4.21.5] +synonym: "tropostasin" RELATED [EC:3.4.21.5] +xref: EC:3.4.21.5 +xref: MetaCyc:3.4.21.5-RXN +xref: Reactome:11540 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003810 +name: protein-glutamine gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] +subset: gosubset_prok +synonym: "factor XIIIa" RELATED [EC:2.3.2.13] +synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] +synonym: "fibrinoligase activity" EXACT [] +synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] +synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] +synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] +synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] +synonym: "TGase activity" EXACT [] +synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] +synonym: "transglutaminase activity" EXACT [] +xref: EC:2.3.2.13 +xref: MetaCyc:2.3.2.13-RXN +xref: Reactome:11549 +xref: RESID:AA0124 +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0003811 +name: complement activity +namespace: molecular_function +def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] +comment: This term was made obsolete because it refers to involvement in a biological process. +is_obsolete: true +consider: GO:0006956 + +[Term] +id: GO:0003812 +name: alternative-complement-pathway C3/C5 convertase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] +comment: This term was made obsolete because it represents a gene product. +synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] +synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] +synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] +synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] +synonym: "C3 proactivator" RELATED [EC:3.4.21.47] +synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] +synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] +synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] +synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] +synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] +synonym: "complement factor B activity" EXACT [EC:3.4.21.47] +synonym: "CVF,Bb" RELATED [EC:3.4.21.47] +synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] +synonym: "heat-labile factor" RELATED [EC:3.4.21.47] +synonym: "proenzyme factor B" EXACT [] +synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] +xref: EC:3.4.21.47 +xref: MetaCyc:3.4.21.47-RXN +xref: Reactome:11550 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003813 +name: classical-complement-pathway C3/C5 convertase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] +comment: This term was made obsolete because it represents a gene product. +synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] +synonym: "C42" RELATED [EC:3.4.21.43] +synonym: "C423" RELATED [EC:3.4.21.43] +synonym: "C4b,2a" RELATED [EC:3.4.21.43] +synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] +synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] +synonym: "complement C2 activity" BROAD [EC:3.4.21.43] +synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] +synonym: "complement C42" RELATED [EC:3.4.21.43] +xref: EC:3.4.21.43 +xref: MetaCyc:3.4.21.43-RXN +xref: Reactome:11551 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003815 +name: complement component C1r activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated complement C1r" RELATED [EC:3.4.21.41] +synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] +synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] +xref: EC:3.4.21.41 +xref: MetaCyc:3.4.21.41-RXN +xref: Reactome:11553 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003816 +name: complement component C1s activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated complement C1s" RELATED [EC:3.4.21.42] +synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] +synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] +synonym: "complement C1s" RELATED [EC:3.4.21.42] +synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] +xref: EC:3.4.21.42 +xref: MetaCyc:3.4.21.42-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003817 +name: complement factor D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] +comment: This term was made obsolete because it represents a gene product. +synonym: "adipsin" EXACT [] +synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] +synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] +synonym: "factor D" RELATED [EC:3.4.21.46] +synonym: "factor D (complement)" RELATED [EC:3.4.21.46] +synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] +xref: EC:3.4.21.46 +xref: MetaCyc:3.4.21.46-RXN +xref: Reactome:11557 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003818 +name: complement factor I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] +comment: This term was made obsolete because it represents a gene product. +synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] +synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] +synonym: "C3bINA" RELATED [EC:3.4.21.45] +synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] +synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] +synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] +synonym: "complement C4bi" RELATED [EC:3.4.21.45] +synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] +synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] +synonym: "factor I" RELATED [EC:3.4.21.45] +xref: EC:3.4.21.45 +xref: MetaCyc:3.4.21.45-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003819 +name: major histocompatibility complex antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "MHC protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003820 +name: class I major histocompatibility complex antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true +consider: GO:0042612 + +[Term] +id: GO:0003821 +name: class II major histocompatibility complex antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true +consider: GO:0042613 + +[Term] +id: GO:0003822 +name: MHC-interacting protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0003823 +name: antigen binding +namespace: molecular_function +def: "Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: goslim_pir +synonym: "antibody" RELATED [] +synonym: "B cell receptor activity" RELATED [] +synonym: "immunoglobulin" RELATED [] +synonym: "opsonin activity" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0003824 +name: catalytic activity +namespace: molecular_function +def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "enzyme activity" RELATED [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0003825 +name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate." [EC:2.4.1.15] +subset: gosubset_prok +synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] +synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] +synonym: "transglucosylase activity" EXACT [] +synonym: "trehalose 6-phosphate synthase activity" EXACT [] +synonym: "trehalose 6-phosphate synthetase activity" EXACT [] +synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] +synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] +synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] +synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] +synonym: "trehalose-phosphate synthase activity" EXACT [] +synonym: "trehalose-phosphate synthetase activity" EXACT [] +synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] +synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] +synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] +synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] +synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] +xref: EC:2.4.1.15 +xref: MetaCyc:TREHALOSE6PSYN-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0003826 +name: alpha-ketoacid dehydrogenase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0003827 +name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2." [EC:2.4.1.101] +synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] +synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] +synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "GnTI" RELATED [EC:2.4.1.101] +synonym: "GNTI activity" EXACT [EC:2.4.1.101] +synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] +synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] +synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] +synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] +synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] +xref: EC:2.4.1.101 +xref: MetaCyc:2.4.1.101-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0003828 +name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R." [EC:2.4.99.8] +synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] +synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] +synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] +synonym: "CMP-NeuAc:LM1(alpha2-8) sialyltranferase activity" EXACT [EC:2.4.99.8] +synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] +synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] +synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] +synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] +synonym: "SAT-2" RELATED [EC:2.4.99.8] +xref: EC:2.4.99.8 +xref: MetaCyc:2.4.99.8-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0003829 +name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] +synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] +synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] +synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] +synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] +synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] +synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] +xref: EC:2.4.1.102 +xref: MetaCyc:2.4.1.102-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0003830 +name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] +subset: gosubset_prok +synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] +synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] +synonym: "GnTIII activity" EXACT [EC:2.4.1.144] +synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] +xref: EC:2.4.1.144 +xref: MetaCyc:2.4.1.144-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0003831 +name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] +synonym: "beta-N-acetyl-beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "GalT activity" RELATED [EC:2.4.1.38] +synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] +synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] +synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] +synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] +synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] +xref: EC:2.4.1.38 +xref: MetaCyc:2.4.1.38-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0003832 +name: beta-alanyl-dopamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] +synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] +synonym: "NBAD hydrolase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0003833 +name: beta-alanyl-dopamine synthase activity +namespace: molecular_function +def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] +synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] +synonym: "NBAD transferase activity" EXACT [] +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0003834 +name: beta-carotene 15,15'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + O2 = 2 retinal." [EC:1.14.99.36] +comment: Note that this function was formerly EC:1.13.11.21. +synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] +synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] +synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] +synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] +xref: EC:1.14.99.36 +xref: MetaCyc:BETA-CAROTENE-15\,15'-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0003835 +name: beta-galactoside alpha-2,6-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] +synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] +synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] +synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] +xref: EC:2.4.99.1 +xref: MetaCyc:2.4.99.1-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0003836 +name: beta-galactoside alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] +synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] +synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] +xref: EC:2.4.99.4 +xref: MetaCyc:2.4.99.4-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0003837 +name: beta-ureidopropionase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] +subset: gosubset_prok +synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] +xref: EC:3.5.1.6 +xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN +xref: Reactome:11609 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0003838 +name: sterol 24-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] +subset: gosubset_prok +synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] +synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] +synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] +synonym: "SMT1 activity" NARROW [EC:2.1.1.41] +synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] +xref: EC:2.1.1.41 +xref: MetaCyc:RXN3O-178 +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0003839 +name: gamma-glutamylcyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] +synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4] +synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4] +synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4] +synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4] +xref: EC:2.3.2.4 +xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0003840 +name: gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] +subset: gosubset_prok +synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] +synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] +synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] +synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] +synonym: "gamma-GPT" RELATED [EC:2.3.2.2] +synonym: "gamma-GT" RELATED [EC:2.3.2.2] +synonym: "gamma-GTP" RELATED [EC:2.3.2.2] +synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] +synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] +synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] +synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] +xref: EC:2.3.2.2 +xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0003841 +name: 1-acylglycerol-3-phosphate O-acyltransferase activity +namespace: molecular_function +alt_id: GO:0004469 +def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate." [EC:2.3.1.51] +subset: gosubset_prok +synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] +synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] +synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] +synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] +synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] +synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] +synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] +synonym: "lysophosphatidate acyltransferase activity" EXACT [] +synonym: "lysophosphatidic acid-acyltransferase activity" EXACT [EC:2.3.1.51] +xref: EC:2.3.1.51 +xref: MetaCyc:RXN-1623 +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0003842 +name: 1-pyrroline-5-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+." [EC:1.5.1.12] +subset: gosubset_prok +synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] +synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] +synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] +synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] +synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] +synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] +xref: EC:1.5.1.12 +xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN +xref: Reactome:11630 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003843 +name: 1,3-beta-glucan synthase activity +namespace: molecular_function +alt_id: GO:0009981 +def: "Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1)." [EC:2.4.1.34] +synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] +synonym: "1,3-beta-D-glucan synthase activity" EXACT [EC:2.4.1.34] +synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] +synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "beta-1,3-glucan synthase activity" EXACT [] +synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] +synonym: "callose synthase activity" EXACT [] +synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] +synonym: "GS-II" RELATED [EC:2.4.1.34] +synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] +synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] +synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] +synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] +xref: EC:2.4.1.34 +xref: MetaCyc:1\,3-BETA-GLUCAN-SYNTHASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0003844 +name: 1,4-alpha-glucan branching enzyme activity +namespace: molecular_function +def: "Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] +synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] +synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] +synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] +synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] +synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] +synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] +synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] +synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] +synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] +synonym: "enzyme Q" RELATED [EC:2.4.1.18] +synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] +synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] +synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] +synonym: "Q-enzyme" RELATED [EC:2.4.1.18] +synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] +xref: EC:2.4.1.18 +xref: MetaCyc:GLYCOGEN-BRANCH-RXN +xref: Reactome:11632 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0003845 +name: 11-beta-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [EC:1.1.1.146, PMID:15761036] +subset: gosubset_prok +synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] +synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] +synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] +synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] +synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] +synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003846 +name: 2-acylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] +synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] +synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] +synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] +synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] +synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] +xref: EC:2.3.1.22 +xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0003847 +name: 1-alkyl-2-acetylglycerophosphocholine esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] +subset: gosubset_prok +synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] +synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] +synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] +synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] +synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] +synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] +synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] +synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] +synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] +synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] +synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] +xref: EC:3.1.1.47 +xref: MetaCyc:3.1.1.47-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0003848 +name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine." [EC:2.7.6.3] +subset: gosubset_prok +synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] +synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] +synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] +synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] +synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] +synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] +synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] +synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] +synonym: "HPPK" RELATED [EC:2.7.6.3] +synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] +xref: EC:2.7.6.3 +xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0003849 +name: 3-deoxy-7-phosphoheptulonate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate." [EC:2.5.1.54] +comment: Note that this function was formerly EC:4.1.2.15. +subset: gosubset_prok +synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] +synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] +synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] +synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] +synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] +synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] +synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] +synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] +synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] +synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] +synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] +synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] +synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] +synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] +synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] +synonym: "DS-Co activity" RELATED [EC:2.5.1.54] +synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] +synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] +synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] +synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] +synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] +synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] +synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] +synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] +synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] +xref: EC:2.5.1.54 +xref: MetaCyc:DAHPSYN-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003850 +name: 2-deoxyglucose-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] +synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] +synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] +xref: EC:3.1.3.68 +xref: MetaCyc:3.1.3.68-RXN +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0003851 +name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] +synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] +synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] +synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] +synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] +synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] +synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] +synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] +synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] +xref: EC:2.4.1.45 +xref: MetaCyc:2.4.1.45-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0003852 +name: 2-isopropylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA." [EC:2.3.3.13] +comment: Note that this function was formerly EC:4.1.3.12. +subset: gosubset_prok +synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] +synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] +synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] +synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] +synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] +synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] +synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] +synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] +xref: EC:2.3.3.13 +xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0003853 +name: 2-methylacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] +synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] +synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] +synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] +synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] +xref: EC:1.3.99.12 +xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0003854 +name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+." [EC:1.1.1.145] +subset: gosubset_prok +synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] +synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] +synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] +synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] +synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] +synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] +synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] +synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] +synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] +synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] +xref: EC:1.1.1.145 +xref: MetaCyc:1.1.1.145-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003855 +name: 3-dehydroquinate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O." [EC:4.2.1.10] +subset: gosubset_prok +synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] +synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] +synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] +synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] +synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] +synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] +synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] +synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] +synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] +synonym: "DHQase" EXACT [EC:4.2.1.10] +xref: EC:4.2.1.10 +xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003856 +name: 3-dehydroquinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate." [EC:4.2.3.4] +subset: gosubset_prok +synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4] +synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] +synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4] +synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] +synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4] +synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4] +synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4] +xref: EC:4.2.3.4 +xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0003857 +name: 3-hydroxyacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35] +comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. +subset: gosubset_prok +synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] +synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] +synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] +synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] +synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] +synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] +synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] +synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] +xref: EC:1.1.1.35 +xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN +xref: Reactome:11645 +xref: UM-BBD_enzymeID:e0664 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003858 +name: 3-hydroxybutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+." [EC:1.1.1.30] +subset: gosubset_prok +synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] +xref: EC:1.1.1.30 +xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN +xref: Reactome:11646 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003859 +name: 3-hydroxybutyryl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O." [EC:4.2.1.55] +subset: gosubset_prok +synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] +synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] +synonym: "crotonase activity" EXACT [EC:4.2.1.55] +synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] +synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] +synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] +xref: EC:4.2.1.55 +xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003860 +name: 3-hydroxyisobutyryl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] +subset: gosubset_prok +synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] +synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] +synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] +xref: EC:3.1.2.4 +xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN +xref: Reactome:11660 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0003861 +name: 3-isopropylmalate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33] +subset: gosubset_prok +synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] +synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] +synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] +synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] +synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] +synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] +xref: EC:4.2.1.33 +xref: MetaCyc:3-ISOPROPYLMALISOM-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003862 +name: 3-isopropylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] +subset: gosubset_prok +synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] +synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] +synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] +synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] +synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] +synonym: "IMDH activity" EXACT [EC:1.1.1.85] +synonym: "IPMDH" RELATED [EC:1.1.1.85] +synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] +xref: EC:1.1.1.85 +xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003863 +name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] +subset: gosubset_prok +synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] +synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] +synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] +synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] +synonym: "BCKDH activity" RELATED [EC:1.2.4.4] +synonym: "BCOAD activity" RELATED [EC:1.2.4.4] +synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] +synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] +xref: EC:1.2.4.4 +xref: MetaCyc:1.2.4.4-RXN +xref: Reactome:11663 +is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + +[Term] +id: GO:0003864 +name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] +subset: gosubset_prok +synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] +synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] +synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] +synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] +synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] +synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] +xref: EC:2.1.2.11 +xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0003865 +name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] +synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] +synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] +synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] +synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] +synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] +synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] +synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] +synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] +synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] +synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] +synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] +synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] +synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] +synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] +xref: EC:1.3.99.5 +xref: MetaCyc:1.3.99.5-RXN +is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0003866 +name: 3-phosphoshikimate 1-carboxyvinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate." [EC:2.5.1.19] +subset: gosubset_prok +synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] +synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] +synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] +synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] +xref: EC:2.5.1.19 +xref: MetaCyc:2.5.1.19-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003867 +name: 4-aminobutyrate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah] +subset: gosubset_prok +synonym: "4-aminobutanoate transaminase activity" EXACT [] +synonym: "4-aminobutyrate aminotransferase activity" EXACT [] +synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19] +synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "GABA transaminase activity" EXACT [] +synonym: "GABA transferase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] +synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19] +synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19] +xref: EC:2.6.1.19 +xref: MetaCyc:GABATRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0003868 +name: 4-hydroxyphenylpyruvate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] +subset: gosubset_prok +synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] +synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] +synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] +xref: EC:1.13.11.27 +xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN +xref: Reactome:11670 +xref: UM-BBD_enzymeID:e0126 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0003869 +name: 4-nitrophenylphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [EC:3.1.3.41] +subset: gosubset_prok +synonym: "4-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] +synonym: "ecto-p-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] +synonym: "K-pNPPase activity" EXACT [EC:3.1.3.41] +synonym: "nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] +synonym: "NPPase activity" EXACT [EC:3.1.3.41] +synonym: "p-nitrophenylphosphatase activity" EXACT [EC:3.1.3.41] +synonym: "p-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] +synonym: "para-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] +synonym: "PNPPase activity" EXACT [EC:3.1.3.41] +xref: EC:3.1.3.41 +xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0003870 +name: 5-aminolevulinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2." [EC:2.3.1.37] +subset: gosubset_prok +synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] +synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] +synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] +synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] +synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] +synonym: "ALAS activity" EXACT [EC:2.3.1.37] +synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] +synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] +synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] +synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] +synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] +synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] +synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] +synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] +synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] +synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] +synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] +synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] +synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] +xref: EC:2.3.1.37 +xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN +xref: Reactome:11690 +is_a: GO:0016749 ! N-succinyltransferase activity + +[Term] +id: GO:0003871 +name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine." [EC:2.1.1.14] +subset: gosubset_prok +synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] +synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] +synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] +synonym: "MetE" RELATED [EC:2.1.1.14] +synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] +synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] +synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] +synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] +synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] +xref: EC:2.1.1.14 +xref: MetaCyc:HOMOCYSMET-RXN +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity + +[Term] +id: GO:0003872 +name: 6-phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] +subset: gosubset_prok +synonym: "6-phosphofructokinase reduction" EXACT [] +synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] +synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] +synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] +synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] +synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] +synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] +synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] +synonym: "PFK" RELATED [EC:2.7.1.11] +synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] +synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] +synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] +synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] +xref: EC:2.7.1.11 +xref: MetaCyc:6PFRUCTPHOS-RXN +xref: Reactome:11692 +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0003873 +name: 6-phosphofructo-2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate." [EC:2.7.1.105] +synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] +synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] +synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] +synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] +synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] +synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] +xref: EC:2.7.1.105 +xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN +xref: Reactome:11695 +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0003874 +name: 6-pyruvoyltetrahydropterin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate." [EC:4.2.3.12] +subset: gosubset_prok +synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] +synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] +synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] +synonym: "PTPS activity" EXACT [EC:4.2.3.12] +xref: EC:4.2.3.12 +xref: MetaCyc:4.2.3.12-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0003875 +name: ADP-ribosylarginine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] +subset: gosubset_prok +synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] +synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] +synonym: "ADPribosylarginine hydrolase activity" EXACT [] +synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] +synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] +synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] +synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] +synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] +xref: EC:3.2.2.19 +xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0003876 +name: AMP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] +synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] +synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] +synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] +synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] +synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenylate deaminase reaction" EXACT [] +synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] +synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] +synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] +synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] +synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] +xref: EC:3.5.4.6 +xref: MetaCyc:AMP-DEAMINASE-RXN +xref: Reactome:11698 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0003877 +name: ATP adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] +subset: gosubset_prok +synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] +synonym: "ADP:ATP adenylyltransferase activity" EXACT [] +synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] +synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] +synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] +synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] +synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] +synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] +xref: EC:2.7.7.53 +xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0003878 +name: ATP citrate synthase activity +namespace: molecular_function +alt_id: GO:0046913 +def: "Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA." [EC:2.3.3.8] +comment: Note that this function was formerly EC:4.1.3.8. +synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] +synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] +synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] +synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] +synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] +synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] +synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] +synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] +synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] +synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] +synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] +synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] +synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] +xref: EC:2.3.3.8 +xref: MetaCyc:ATP-CITRATE-(PRO-S-)-LYASE-RXN +xref: MetaCyc:PWY-5172 +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0003879 +name: ATP phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] +subset: gosubset_prok +synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] +synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] +synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] +xref: EC:2.4.2.17 +xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0003880 +name: C-terminal protein carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carbon atom of the C-terminal residue of a protein." [PMID:8428937] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008276 ! protein methyltransferase activity + +[Term] +id: GO:0003881 +name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol." [EC:2.7.8.11] +subset: gosubset_prok +synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] +synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] +synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] +synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] +synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] +synonym: "phosphatidylinositol synthase activity" EXACT [] +xref: EC:2.7.8.11 +xref: MetaCyc:2.7.8.11-RXN +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0003882 +name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] +subset: gosubset_prok +synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] +synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] +synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] +synonym: "PS synthase activity" EXACT [EC:2.7.8.8] +synonym: "serine exchange enzyme" BROAD [] +xref: EC:2.7.8.8 +xref: MetaCyc:PHOSPHASERSYN-RXN +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0003883 +name: CTP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] +subset: gosubset_prok +synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] +synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] +synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] +synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] +synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] +synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] +xref: EC:6.3.4.2 +xref: MetaCyc:CTPSYN-RXN +xref: Reactome:11718 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0003884 +name: D-amino-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.3] +subset: gosubset_prok +synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] +synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] +synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] +xref: EC:1.4.3.3 +xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0003885 +name: D-arabinono-1,4-lactone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = D-erythro-ascorbate + H2O2." [EC:1.1.3.37] +subset: gosubset_prok +synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] +xref: EC:1.1.3.37 +xref: MetaCyc:1.1.3.37-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0003886 +name: DNA (cytosine-5-)-methyltransferase activity +namespace: molecular_function +alt_id: GO:0008326 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] +comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). +subset: gosubset_prok +synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] +synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] +synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] +synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] +synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] +synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] +synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] +synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] +synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] +synonym: "DNA cytosine c5 methylase activity" EXACT [EC:2.1.1.37] +synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] +synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] +synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] +synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] +synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "modification methylase activity" RELATED [EC:2.1.1.37] +synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] +synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] +synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] +synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] +xref: EC:2.1.1.37 +xref: MetaCyc:2.1.1.73-RXN +xref: MetaCyc:DNA-(CYTOSINE-5-)-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0009008 ! DNA-methyltransferase activity + +[Term] +id: GO:0003887 +name: DNA-directed DNA polymerase activity +namespace: molecular_function +alt_id: GO:0003888 +alt_id: GO:0003889 +alt_id: GO:0003890 +alt_id: GO:0003891 +alt_id: GO:0003893 +alt_id: GO:0003894 +alt_id: GO:0003895 +alt_id: GO:0008723 +alt_id: GO:0015999 +alt_id: GO:0016000 +alt_id: GO:0016448 +alt_id: GO:0016449 +alt_id: GO:0016450 +alt_id: GO:0016451 +alt_id: GO:0016452 +alt_id: GO:0019984 +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684] +subset: gosubset_prok +synonym: "alpha DNA polymerase activity" NARROW [] +synonym: "beta DNA polymerase activity" NARROW [] +synonym: "delta DNA polymerase activity" NARROW [] +synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] +synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] +synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] +synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] +synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] +synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] +synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase V activity" NARROW [] +synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] +synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] +synonym: "duplicase" BROAD [EC:2.7.7.7] +synonym: "epsilon DNA polymerase activity" NARROW [] +synonym: "eta DNA polymerase activity" NARROW [] +synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] +synonym: "iota DNA polymerase activity" NARROW [] +synonym: "kappa DNA polymerase activity" NARROW [] +synonym: "Klenow fragment" NARROW [EC:2.7.7.7] +synonym: "lambda DNA polymerase activity" NARROW [] +synonym: "mu DNA polymerase activity" NARROW [] +synonym: "nu DNA polymerase activity" NARROW [] +synonym: "sequenase" RELATED [EC:2.7.7.7] +synonym: "sigma DNA polymerase activity" NARROW [] +synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] +synonym: "Taq Pol I" NARROW [EC:2.7.7.7] +synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] +synonym: "theta DNA polymerase activity" NARROW [] +synonym: "zeta DNA polymerase activity" NARROW [] +xref: EC:2.7.7.- +xref: EC:2.7.7.7 +xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN +xref: Reactome:11722 +xref: Reactome:11738 +xref: Reactome:26112 +xref: Reactome:69114 +is_a: GO:0034061 ! DNA polymerase activity + +[Term] +id: GO:0003892 +name: proliferating cell nuclear antigen +namespace: molecular_function +alt_id: GO:0005661 +def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] +comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "PCNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003896 +name: DNA primase activity +namespace: molecular_function +alt_id: GO:0003897 +alt_id: GO:0003898 +def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094] +subset: gosubset_prok +xref: EC:2.7.7.- +is_a: GO:0003899 ! DNA-directed RNA polymerase activity + +[Term] +id: GO:0003899 +name: DNA-directed RNA polymerase activity +namespace: molecular_function +alt_id: GO:0000129 +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] +subset: gosubset_prok +synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] +synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] +synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] +synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] +synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] +synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] +synonym: "DNA-directed RNA polymerase I activity" NARROW [] +synonym: "DNA-directed RNA polymerase II activity" NARROW [] +synonym: "DNA-directed RNA polymerase III activity" NARROW [] +synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] +synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] +synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] +synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] +synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] +synonym: "transcriptase" BROAD [EC:2.7.7.6] +xref: EC:2.7.7.6 +xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN +xref: Reactome:11745 +is_a: GO:0034062 ! RNA polymerase activity + +[Term] +id: GO:0003900 +name: DNA-directed RNA polymerase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] +comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0003901 +name: DNA-directed RNA polymerase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] +comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0003902 +name: DNA-directed RNA polymerase III activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] +comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0003904 +name: deoxyribodipyrimidine photo-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). The enzyme catalyzes the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme." [EC:4.1.99.3] +comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. +subset: gosubset_prok +synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] +synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] +synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] +synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] +synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] +synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] +synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] +synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] +synonym: "photolyase activity" EXACT [EC:4.1.99.3] +synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] +synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] +synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] +synonym: "PRE" RELATED [EC:4.1.99.3] +xref: EC:4.1.99.3 +xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN +is_a: GO:0003913 ! DNA photolyase activity + +[Term] +id: GO:0003905 +name: alkylbase DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0004036 +def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] +subset: gosubset_prok +synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] +synonym: "AlkA" RELATED [EC:3.2.2.21] +synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] +synonym: "alkylbase DNA glycosidase activity" EXACT [] +synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] +synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] +synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] +synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] +xref: EC:3.2.2.21 +xref: MetaCyc:3.2.2.21-RXN +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0003906 +name: DNA-(apurinic or apyrimidinic site) lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] +comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. +subset: gosubset_prok +synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18] +synonym: "AP lyase activity" EXACT [EC:4.2.99.18] +synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] +synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] +synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] +synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18] +synonym: "E. coli endonuclease III activity" NARROW [EC:4.2.99.18] +synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] +synonym: "endonuclease VIII activity" RELATED [] +synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18] +synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18] +synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18] +synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18] +synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18] +synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18] +xref: EC:4.2.99.18 +xref: MetaCyc:4.2.99.18-RXN +xref: Reactome:12450 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0003908 +name: methylated-DNA-[protein]-cysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] +comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. +subset: gosubset_prok +synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] +synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] +synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] +synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] +synonym: "MGMT" EXACT [] +synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] +synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] +xref: EC:2.1.1.63 +xref: MetaCyc:2.1.1.63-RXN +xref: Reactome:12455 +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0003909 +name: DNA ligase activity +namespace: molecular_function +def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another; requires an energy source such as ATP or NAD+." [ISBN:0716720094] +subset: gosubset_prok +xref: EC:6.5.1.- +xref: Reactome:12459 +is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds + +[Term] +id: GO:0003910 +name: DNA ligase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] +subset: gosubset_prok +synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] +synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] +synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] +synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] +synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] +synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] +synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] +synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] +synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] +synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] +synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] +synonym: "sealase activity" RELATED [EC:6.5.1.1] +xref: EC:6.5.1.1 +xref: MetaCyc:DNA-LIGASE-(ATP)-RXN +is_a: GO:0003909 ! DNA ligase activity + +[Term] +id: GO:0003911 +name: DNA ligase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] +subset: gosubset_prok +synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] +synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] +synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] +synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] +synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] +synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] +synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] +synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] +synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] +synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] +synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] +synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] +synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] +synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] +synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] +synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] +synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] +xref: EC:6.5.1.2 +xref: MetaCyc:DNA-LIGASE-(NAD(+))-RXN +is_a: GO:0003909 ! DNA ligase activity + +[Term] +id: GO:0003912 +name: DNA nucleotidylexotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] +synonym: "addase activity" EXACT [EC:2.7.7.31] +synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] +synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] +synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] +synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] +synonym: "TdT" RELATED [EC:2.7.7.31] +synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] +synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] +synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] +synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] +synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] +xref: EC:2.7.7.31 +xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0003913 +name: DNA photolyase activity +namespace: molecular_function +def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] +subset: gosubset_prok +xref: EC:4.1.99.- +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0003914 +name: DNA (6-4) photolyase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] +is_a: GO:0003913 ! DNA photolyase activity + +[Term] +id: GO:0003916 +name: DNA topoisomerase activity +namespace: molecular_function +alt_id: GO:0009387 +def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] +subset: gosubset_prok +xref: EC:5.99.1.- +is_a: GO:0003677 ! DNA binding +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0003917 +name: DNA topoisomerase type I activity +namespace: molecular_function +def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] +comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. +subset: gosubset_prok +synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] +synonym: "DNA topoisomerase I activity" NARROW [] +synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] +synonym: "omega-protein activity" RELATED [EC:5.99.1.2] +synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] +synonym: "swivelase activity" RELATED [EC:5.99.1.2] +synonym: "topoisomerase" BROAD [EC:5.99.1.2] +synonym: "type I DNA topoisomerase activity" EXACT [] +synonym: "type I topoisomerase activity" EXACT [] +synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] +xref: EC:5.99.1.2 +xref: MetaCyc:5.99.1.2-RXN +is_a: GO:0003916 ! DNA topoisomerase activity + +[Term] +id: GO:0003918 +name: DNA topoisomerase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] +subset: gosubset_prok +synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3] +synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3] +synonym: "DNA gyrase activity" NARROW [] +synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3] +synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3] +synonym: "DNA topoisomerase IV activity" EXACT [] +synonym: "DNA topoisomerase type II activity" EXACT [] +synonym: "DNA-gyrase activity" EXACT [EC:5.99.1.3] +synonym: "topoisomerase" BROAD [EC:5.99.1.3] +synonym: "topoisomerase II" EXACT [] +synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3] +xref: EC:5.99.1.3 +xref: MetaCyc:5.99.1.3-RXN +is_a: GO:0003916 ! DNA topoisomerase activity + +[Term] +id: GO:0003919 +name: FMN adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2] +subset: gosubset_prok +synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] +synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] +synonym: "ATP:FMN adenylyltransferase activity" EXACT [] +synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] +synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] +synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] +synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] +synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] +synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] +synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] +xref: EC:2.7.7.2 +xref: MetaCyc:FADSYN-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0003920 +name: GMP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+." [EC:1.7.1.7] +comment: Note that this function was formerly EC:1.6.6.8. +subset: gosubset_prok +synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] +synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] +synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] +synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] +synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] +synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] +synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] +synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] +synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] +xref: EC:1.7.1.7 +xref: MetaCyc:GMP-REDUCT-RXN +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0003921 +name: GMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1] +synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1] +synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1] +synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1] +synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1] +synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1] +synonym: "XMP aminase activity" EXACT [EC:6.3.4.1] +xref: EC:6.3.4.1 +xref: MetaCyc:GMP-SYN-NH3-RXN +xref: Reactome:12506 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0003922 +name: GMP synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2] +subset: gosubset_prok +synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] +synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] +synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] +synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] +synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] +synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] +synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] +synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] +synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] +xref: EC:6.3.5.2 +xref: MetaCyc:GMP-SYN-GLUT-RXN +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0003923 +name: GPI-anchor transamidase activity +namespace: molecular_function +def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309 "Biochemical Pathways"] +xref: EC:3.-.-.- +xref: Reactome:12511 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0003924 +name: GTPase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] +comment: Consider also annotating to the molecular function term 'GTP binding ; GO:0005525'. +subset: gosubset_prok +synonym: "ARF small monomeric GTPase activity" NARROW [] +synonym: "dynamin GTPase activity" NARROW [] +synonym: "heterotrimeric G-protein GTPase activity" NARROW [] +synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] +synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] +synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] +synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] +synonym: "protein-synthesizing GTPase activity" NARROW [] +synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] +synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] +synonym: "protein-synthesizing GTPase activity, termination" NARROW [] +synonym: "Rab small monomeric GTPase activity" NARROW [] +synonym: "Ran small monomeric GTPase activity" NARROW [] +synonym: "Ras small monomeric GTPase activity" NARROW [] +synonym: "RHEB small monomeric GTPase activity" NARROW [] +synonym: "Rho small monomeric GTPase activity" NARROW [] +synonym: "Sar small monomeric GTPase activity" NARROW [] +synonym: "signal-recognition-particle GTPase activity" NARROW [] +synonym: "small monomeric GTPase activity" NARROW [] +synonym: "tubulin GTPase activity" NARROW [] +xref: Reactome:12513 +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0003925 +name: small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN] +comment: This term was made obsolete because it represents a gene product and contains cellular component information. +is_obsolete: true +replaced_by: GO:0003924 + +[Term] +id: GO:0003926 +name: ARF small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0016191 +consider: GO:0016192 + +[Term] +id: GO:0003927 +name: heterotrimeric G-protein GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN] +comment: This term was made obsolete because it represents a cellular component. +is_obsolete: true +replaced_by: GO:0003924 +replaced_by: GO:0005834 + +[Term] +id: GO:0003928 +name: RAB small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0016191 +consider: GO:0016192 + +[Term] +id: GO:0003929 +name: RAN small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0006606 + +[Term] +id: GO:0003930 +name: RAS small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0001558 + +[Term] +id: GO:0003931 +name: Rho small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0007010 + +[Term] +id: GO:0003932 +name: SAR small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0046903 + +[Term] +id: GO:0003933 +name: GTP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [GOC:jl, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +xref: EC:3.5.4.- +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0003934 +name: GTP cyclohydrolase I activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [EC:3.5.4.16] +subset: gosubset_prok +synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] +synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] +synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] +synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] +synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] +xref: EC:3.5.4.16 +xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0003935 +name: GTP cyclohydrolase II activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate." [EC:3.5.4.25] +subset: gosubset_prok +synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] +synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] +synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] +xref: EC:3.5.4.25 +xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0003936 +name: hydrogen-transporting two-sector ATPase activity +namespace: molecular_function +alt_id: GO:0004006 +alt_id: GO:0008729 +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] +comment: This term was made obsolete because it refers to a bifunctional gene product. +synonym: "proton-transporting two-sector ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0046933 +consider: GO:0046961 + +[Term] +id: GO:0003937 +name: IMP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] +subset: gosubset_prok +synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] +synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] +synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] +synonym: "inosinicase activity" EXACT [EC:3.5.4.10] +xref: EC:3.5.4.10 +xref: MetaCyc:IMPCYCLOHYDROLASE-RXN +xref: Reactome:12558 +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0003938 +name: IMP dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] +subset: gosubset_prok +synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] +synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] +synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] +synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] +synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] +synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] +synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] +synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] +xref: EC:1.1.1.205 +xref: MetaCyc:IMP-DEHYDROG-RXN +xref: Reactome:12563 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003939 +name: L-iditol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] +comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. +subset: gosubset_prok +synonym: " L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14] +synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14] +synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] +synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] +synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] +xref: EC:1.1.1.14 +xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003940 +name: L-iduronidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in desulfated dermatan." [EC:3.2.1.76] +synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] +synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] +xref: EC:3.2.1.76 +xref: MetaCyc:3.2.1.76-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0003941 +name: L-serine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] +comment: Note that this function was formerly EC:4.3.1.13. +subset: gosubset_prok +synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] +synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] +synonym: "L-serine deaminase activity" EXACT [] +synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] +synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] +synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] +xref: EC:4.3.1.17 +xref: MetaCyc:4.3.1.17-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0003942 +name: N-acetyl-gamma-glutamyl-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] +subset: gosubset_prok +synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] +synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] +synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] +synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] +synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] +synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] +synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] +xref: EC:1.2.1.38 +xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003943 +name: N-acetylgalactosamine-4-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] +subset: gosubset_prok +synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] +synonym: "arylsulfatase B" EXACT [] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] +synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] +synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] +synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] +xref: EC:3.1.6.12 +xref: MetaCyc:3.1.6.12-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0003944 +name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] +synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] +synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] +synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] +synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] +synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] +synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] +xref: EC:3.1.4.45 +xref: MetaCyc:3.1.4.45-RXN +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0003945 +name: N-acetyllactosamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] +subset: gosubset_prok +synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] +synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "beta-N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "beta1-4GalT" RELATED [EC:2.4.1.90] +synonym: "Gal-T" RELATED [EC:2.4.1.90] +synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] +synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] +synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] +synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "N-acetylglucosamine (beta1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] +synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase activity" EXACT [EC:2.4.1.90] +synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] +xref: EC:2.4.1.90 +xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0003947 +name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] +synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] +synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] +synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] +synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] +synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] +synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] +xref: EC:2.4.1.92 +xref: MetaCyc:2.4.1.92-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0003948 +name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-glucosaminylamine + L-aspartate." [EC:3.5.1.26] +subset: gosubset_prok +synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] +synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] +synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] +synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] +synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] +synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] +synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] +synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] +synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] +synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] +synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] +xref: EC:3.5.1.26 +xref: MetaCyc:3.5.1.26-RXN +is_a: GO:0004067 ! asparaginase activity + +[Term] +id: GO:0003949 +name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide." [EC:5.3.1.16] +subset: gosubset_prok +synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] +synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] +synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] +synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] +synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] +synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] +xref: EC:5.3.1.16 +xref: MetaCyc:PRIBFAICARPISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0003950 +name: NAD+ ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] +subset: gosubset_prok +synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] +synonym: "NAD ADP-ribosyltransferase activity" EXACT [] +synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] +synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] +synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] +synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] +synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] +xref: EC:2.4.2.30 +xref: MetaCyc:NAD(+)-ADP-RIBOSYLTRANSFERASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0003951 +name: NAD+ kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NAD+ = ADP + NADP+." [EC:2.7.1.23] +subset: gosubset_prok +synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] +synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] +synonym: "NAD kinase activity" EXACT [] +synonym: "NADK" RELATED [EC:2.7.1.23] +synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] +synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] +xref: EC:2.7.1.23 +xref: MetaCyc:NAD-KIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0003952 +name: NAD+ synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] +subset: gosubset_prok +synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] +synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] +synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] +synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] +synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] +synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] +synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] +synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] +synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] +xref: EC:6.3.5.1 +xref: MetaCyc:NAD-SYNTH-GLN-RXN +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0003953 +name: NAD+ nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5] +subset: gosubset_prok +synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5] +synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5] +synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5] +synonym: "DPNase activity" EXACT [EC:3.2.2.5] +synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5] +synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5] +synonym: "NAD nucleosidase activity" EXACT [] +synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5] +synonym: "NADase activity" EXACT [EC:3.2.2.5] +synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5] +synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5] +xref: EC:3.2.2.5 +xref: MetaCyc:NADNUCLEOSID-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0003954 +name: NADH dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] +subset: gosubset_prok +synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] +synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] +synonym: "diaphorase activity" BROAD [EC:1.6.99.3] +synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] +synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] +synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] +synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] +synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] +synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] +synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] +synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] +synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] +synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] +synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] +synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] +synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] +synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] +synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] +synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] +xref: EC:1.6.99.3 +xref: MetaCyc:NADH-DEHYDROGENASE-RXN +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0003955 +name: NAD(P)H dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)(+) + a hydroquinone." [EC:1.6.5.2] +subset: gosubset_prok +synonym: "azoreductase activity" BROAD [EC:1.6.5.2] +synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] +synonym: "diaphorase activity" BROAD [EC:1.6.5.2] +synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] +synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] +synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] +synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] +synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] +synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] +synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] +synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] +synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] +synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] +synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] +synonym: "NQO1" RELATED [EC:1.6.5.2] +synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] +synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] +synonym: "QR1" RELATED [EC:1.6.5.2] +synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] +synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] +synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] +synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] +synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] +synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] +xref: EC:1.6.5.2 +xref: MetaCyc:NQOR-RXN +xref: UM-BBD_enzymeID:e0202 +is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor + +[Term] +id: GO:0003956 +name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] +synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] +synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] +synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] +synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] +synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] +synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] +synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] +synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] +synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] +synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] +synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] +synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] +xref: EC:2.4.2.31 +xref: MetaCyc:2.4.2.31-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0003957 +name: NAD(P)+ transhydrogenase (B-specific) activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid=6006l3] +subset: gosubset_prok +synonym: "H+-thase" BROAD [EC:1.6.1.1] +synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] +synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] +synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] +synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] +synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] +synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] +synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] +xref: EC:1.6.1.1 +xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN +is_a: GO:0008746 ! NAD(P) transhydrogenase activity +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity + +[Term] +id: GO:0003958 +name: NADPH-hemoprotein reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] +subset: gosubset_prok +synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] +synonym: "CPR activity" RELATED [EC:1.6.2.4] +synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] +synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] +synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] +synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] +synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] +synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] +synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] +synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] +synonym: "NADPH:cytochrome c reductase activity" EXACT [] +synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] +synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] +synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] +synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] +synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] +synonym: "POR" RELATED [EC:1.6.2.4] +synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] +synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] +xref: EC:1.6.2.4 +xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN +is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor + +[Term] +id: GO:0003959 +name: NADPH dehydrogenase activity +namespace: molecular_function +alt_id: GO:0008468 +alt_id: GO:0016660 +def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1] +subset: gosubset_prok +synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] +synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] +synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] +synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] +synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] +synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] +synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] +synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] +synonym: "OYE" RELATED [EC:1.6.99.1] +synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] +synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] +synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] +synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] +synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] +xref: EC:1.6.99.1 +xref: MetaCyc:NADPH-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0523 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0003960 +name: NADPH:quinone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] +subset: gosubset_prok +synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] +synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] +synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] +xref: EC:1.6.5.5 +xref: MetaCyc:QOR-RXN +is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor + +[Term] +id: GO:0003961 +name: O-acetylhomoserine aminocarboxypropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [EC:2.5.1.49] +comment: Note that this function was formerly EC:4.2.99.10. +subset: gosubset_prok +synonym: "4.2.99.9" RELATED [] +synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] +synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] +synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] +synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] +synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] +synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] +xref: EC:2.5.1.49 +xref: MetaCyc:O-ACETYLHOMOSERINE-(THIOL)-LYASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003962 +name: cystathionine gamma-synthase activity +namespace: molecular_function +alt_id: GO:0000505 +def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] +comment: Formerly EC 4.2.99.9. +subset: gosubset_prok +synonym: "CTT gamma synthase activity" EXACT [] +synonym: "cystathionine g-synthase activity" EXACT [] +synonym: "cystathionine gamma synthase activity" EXACT [] +synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] +synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] +synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] +synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] +synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] +synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] +synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] +synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] +synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] +synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] +synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] +xref: EC:2.5.1.48 +xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003963 +name: RNA-3'-phosphate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] +subset: gosubset_prok +synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] +synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] +synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] +xref: EC:6.5.1.4 +xref: MetaCyc:RNA-3'-PHOSPHATE-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds + +[Term] +id: GO:0003964 +name: RNA-directed DNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] +subset: gosubset_prok +synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] +synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] +synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] +synonym: "revertase activity" RELATED [EC:2.7.7.49] +synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] +synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] +synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] +synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] +synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] +synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] +synonym: "RT" RELATED [EC:2.7.7.49] +xref: EC:2.7.7.49 +xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN +xref: Reactome:10568 +is_a: GO:0034061 ! DNA polymerase activity + +[Term] +id: GO:0003966 +name: RNA-directed DNA polymerase, transposon encoded +namespace: molecular_function +def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] +comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. +is_obsolete: true +replaced_by: GO:0003964 + +[Term] +id: GO:0003967 +name: RNA-directed DNA polymerase, group II intron encoded +namespace: molecular_function +def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] +comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. +is_obsolete: true +replaced_by: GO:0003964 + +[Term] +id: GO:0003968 +name: RNA-directed RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA (n) = diphosphate + RNA (n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] +subset: gosubset_prok +synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] +synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] +synonym: "PB1 proteins" RELATED [EC:2.7.7.48] +synonym: "PB2 proteins" RELATED [EC:2.7.7.48] +synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] +synonym: "polymerase L" RELATED [EC:2.7.7.48] +synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] +synonym: "RDRP" RELATED [EC:2.7.7.48] +synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] +synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] +synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] +synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] +synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] +synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] +synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] +synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] +synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] +synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] +synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] +synonym: "transcriptase" BROAD [EC:2.7.7.48] +xref: EC:2.7.7.48 +xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN +xref: Reactome:12642 +is_a: GO:0034062 ! RNA polymerase activity + +[Term] +id: GO:0003969 +name: RNA editase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true + +[Term] +id: GO:0003972 +name: RNA ligase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)." [EC:6.5.1.3] +subset: gosubset_prok +synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] +synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] +synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] +synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] +xref: EC:6.5.1.3 +xref: MetaCyc:RNA-LIGASE-(ATP)-RXN +is_a: GO:0008452 ! RNA ligase activity + +[Term] +id: GO:0003973 +name: (S)-2-hydroxy-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2." [EC:1.1.3.15] +subset: gosubset_prok +synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] +synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] +synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] +synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] +synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] +synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] +synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] +xref: EC:1.1.3.15 +xref: MetaCyc:(S)-2-HYDROXY-ACID-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0003974 +name: UDP-N-acetylglucosamine 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] +subset: gosubset_prok +synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] +synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] +synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] +synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] +synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] +synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] +xref: EC:5.1.3.7 +xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0003975 +name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] +subset: gosubset_prok +synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] +synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] +synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] +synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] +synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] +synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] +xref: EC:2.7.8.15 +xref: MetaCyc:2.7.8.15-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0003976 +name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] +synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] +synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] +synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] +synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] +synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] +synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] +synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] +xref: EC:2.7.8.17 +xref: MetaCyc:2.7.8.17-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0003977 +name: UDP-N-acetylglucosamine diphosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine." [EC:2.7.7.23] +subset: gosubset_prok +synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] +synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] +synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] +synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] +synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] +synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] +synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] +synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] +synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] +synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] +synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] +xref: EC:2.7.7.23 +xref: MetaCyc:NAG1P-URIDYLTRANS-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0003978 +name: UDP-glucose 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] +subset: gosubset_prok +synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] +synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] +synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] +synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] +xref: EC:5.1.3.2 +xref: MetaCyc:UDPGLUCEPIM-RXN +xref: Reactome:12673 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0003979 +name: UDP-glucose 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + H+." [EC:1.1.1.22] +subset: gosubset_prok +xref: EC:1.1.1.22 +xref: MetaCyc:UGD-RXN +xref: Reactome:12674 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003980 +name: UDP-glucose:glycoprotein glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [PMID:10764828] +synonym: "UGGT activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0003983 +name: UTP:glucose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose." [EC:2.7.7.9] +subset: gosubset_prok +synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] +synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] +synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] +synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] +xref: EC:2.7.7.9 +xref: MetaCyc:GLUC1PURIDYLTRANS-RXN +xref: Reactome:12708 +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0003984 +name: acetolactate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] +comment: Note that this function was formerly EC:4.1.3.18. +subset: gosubset_prok +synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] +synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] +synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] +synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] +synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] +synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] +synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] +synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] +synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] +xref: EC:2.2.1.6 +xref: MetaCyc:ACETOLACTSYN-RXN +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0003985 +name: acetyl-CoA C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] +subset: gosubset_prok +synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] +synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] +synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] +synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] +synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] +synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] +synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] +synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] +synonym: "thiolase II" RELATED [EC:2.3.1.9] +xref: EC:2.3.1.9 +xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN +xref: UM-BBD_enzymeID:e0144 +is_a: GO:0016453 ! C-acetyltransferase activity + +[Term] +id: GO:0003986 +name: acetyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O = CoA + acetate." [EC:3.1.2.1] +subset: gosubset_prok +synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] +synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] +synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] +synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] +synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] +synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] +xref: EC:3.1.2.1 +xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0003987 +name: acetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] +subset: gosubset_prok +synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] +synonym: "acetate to acetyl-CoA" RELATED [] +synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] +synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] +synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] +synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] +synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] +synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] +synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] +synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] +synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] +synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] +synonym: "ACS" RELATED [EC:6.2.1.1] +synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] +synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] +synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] +xref: EC:6.2.1.1 +xref: MetaCyc:ACETATE--COA-LIGASE-RXN +xref: Reactome:12714 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0003988 +name: acetyl-CoA C-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] +subset: gosubset_prok +synonym: "2-keto-acyl thiolase activity" EXACT [] +synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] +synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] +synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] +synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] +synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] +synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] +synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] +synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] +synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] +synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] +synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] +synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] +synonym: "KAT" RELATED [EC:2.3.1.16] +synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] +synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] +synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] +synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] +synonym: "thiolase I" RELATED [EC:2.3.1.16] +xref: EC:2.3.1.16 +xref: MetaCyc:KETOACYLCOATHIOL-RXN +xref: UM-BBD_enzymeID:e0653 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0003989 +name: acetyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] +subset: gosubset_prok +synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] +synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] +xref: EC:6.4.1.2 +xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN +xref: Reactome:12716 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0003990 +name: acetylcholinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] +subset: gosubset_prok +synonym: "AcCholE" RELATED [EC:3.1.1.7] +synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] +synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] +synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] +synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] +synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] +synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] +xref: EC:3.1.1.7 +xref: MetaCyc:ACETYLCHOLINESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0003991 +name: acetylglutamate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate." [EC:2.7.2.8] +subset: gosubset_prok +synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] +synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] +synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] +synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] +synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] +synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] +xref: EC:2.7.2.8 +xref: MetaCyc:ACETYLGLUTKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0003992 +name: acetylornithine transaminase activity +namespace: molecular_function +alt_id: GO:0047318 +def: "Catalysis of the reaction: N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11] +subset: gosubset_prok +synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] +synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] +synonym: "acetylornithine aminotransferase activity" EXACT [] +synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] +synonym: "ACOAT activity" EXACT [EC:2.6.1.11] +synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] +synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] +synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] +synonym: "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] +synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] +synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] +synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] +synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] +xref: EC:2.6.1.11 +xref: MetaCyc:ACETYLORNTRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0003993 +name: acid phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] +subset: gosubset_prok +synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] +synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] +synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] +synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] +synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] +synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] +synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] +synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] +synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] +synonym: "uteroferrin" RELATED [EC:3.1.3.2] +xref: EC:3.1.3.2 +xref: MetaCyc:ACID-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0003994 +name: aconitate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3] +subset: gosubset_prok +synonym: "aconitase activity" EXACT [] +synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] +synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] +synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] +synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] +xref: EC:4.2.1.3 +xref: MetaCyc:ACONITATEDEHYDR-RXN +xref: Reactome:12740 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003995 +name: acyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] +subset: gosubset_prok +synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] +synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] +synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] +synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] +synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] +xref: EC:1.3.99.3 +xref: MetaCyc:ACYLCOADEHYDROG-RXN +xref: Reactome:4266 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0003996 +name: acyl-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acyl + ATP + CoASH = AMP + diphosphate + acyl-CoA." [GOC:mah] +subset: gosubset_prok +xref: EC:6.2.1.- +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0003997 +name: acyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2." [EC:1.3.3.6] +subset: gosubset_prok +synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] +synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] +synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] +synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] +xref: EC:1.3.3.6 +xref: MetaCyc:ACYL-COA-OXIDASE-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0003998 +name: acylphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] +subset: gosubset_prok +synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] +synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] +synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] +synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] +synonym: "GP 1-3" RELATED [EC:3.6.1.7] +synonym: "Ho 1-3" RELATED [EC:3.6.1.7] +xref: EC:3.6.1.7 +xref: MetaCyc:ACYLPHOSPHATASE-RXN +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0003999 +name: adenine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] +subset: gosubset_prok +synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] +synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] +synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] +synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] +synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] +synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] +synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] +synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] +synonym: "APRT activity" EXACT [EC:2.4.2.7] +synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] +xref: EC:2.4.2.7 +xref: MetaCyc:ADENPRIBOSYLTRAN-RXN +xref: Reactome:12749 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004000 +name: adenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] +subset: gosubset_prok +synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] +synonym: "adenosine deaminase reaction" EXACT [] +xref: EC:3.5.4.4 +xref: MetaCyc:ADENODEAMIN-RXN +xref: Reactome:6985 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004001 +name: adenosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] +subset: gosubset_prok +synonym: "adenosine 5-phosphotransferase activity" EXACT [] +synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] +synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] +xref: EC:2.7.1.20 +xref: MetaCyc:ADENOSINE-KINASE-RXN +xref: Reactome:6989 +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0004003 +name: ATP-dependent DNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0003678 ! DNA helicase activity +is_a: GO:0008026 ! ATP-dependent helicase activity +is_a: GO:0008094 ! DNA-dependent ATPase activity + +[Term] +id: GO:0004004 +name: ATP-dependent RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0003724 ! RNA helicase activity +is_a: GO:0008026 ! ATP-dependent helicase activity +is_a: GO:0008186 ! RNA-dependent ATPase activity + +[Term] +id: GO:0004005 +name: plasma membrane cation-transporting ATPase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0005886 +consider: GO:0019829 + +[Term] +id: GO:0004007 +name: heavy metal-exporting ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +is_obsolete: true +consider: GO:0046873 + +[Term] +id: GO:0004008 +name: copper-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [EC:3.6.3.4] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4] +synonym: "copper exporting ATPase activity" EXACT [] +synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4] +synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4] +synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] +synonym: "cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] +xref: EC:3.6.3.4 +xref: MetaCyc:3.6.3.4-RXN +is_a: GO:0043682 ! copper-transporting ATPase activity + +[Term] +id: GO:0004009 +name: ATP-binding cassette (ABC) transporter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0004012 +name: phospholipid-translocating ATPase activity +namespace: molecular_function +alt_id: GO:0008557 +def: "Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "aminophospholipid-transporting ATPase" NARROW [] +synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1] +synonym: "flippase activity" BROAD [EC:3.6.3.1] +synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1] +synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1] +synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1] +synonym: "phospholipid translocating ATPase activity" EXACT [] +synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1] +xref: EC:3.6.3.1 +xref: MetaCyc:3.6.3.1-RXN +is_a: GO:0015247 ! aminophospholipid transporter activity +is_a: GO:0043492 ! ATPase activity, coupled to movement of substances + +[Term] +id: GO:0004013 +name: adenosylhomocysteinase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] +subset: gosubset_prok +synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] +synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] +synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] +synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] +synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] +synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] +synonym: "SAHase activity" EXACT [EC:3.3.1.1] +xref: EC:3.3.1.1 +xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN +xref: Reactome:7047 +is_a: GO:0016802 ! trialkylsulfonium hydrolase activity + +[Term] +id: GO:0004014 +name: adenosylmethionine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2." [EC:4.1.1.50] +subset: gosubset_prok +synonym: "adenosyl methionine decarboxylase activity" EXACT [] +synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] +synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] +synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] +synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] +xref: EC:4.1.1.50 +xref: MetaCyc:SAMDECARB-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004015 +name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate." [EC:2.6.1.62] +subset: gosubset_prok +synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] +synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] +synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] +synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] +synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] +synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] +synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] +synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] +synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] +synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] +synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] +synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] +synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] +synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] +xref: EC:2.6.1.62 +xref: MetaCyc:DAPASYN-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004016 +name: adenylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] +subset: gosubset_prok +synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] +synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] +synonym: "adenylyl cyclase activity" EXACT [] +synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] +synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] +synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] +synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] +synonym: "cAMP generating peptide activity" RELATED [] +xref: EC:4.6.1.1 +xref: MetaCyc:ADENYLATECYC-RXN +xref: Reactome:7056 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0004017 +name: adenylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] +subset: gosubset_prok +synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] +synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] +synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] +synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] +synonym: "myokinase activity" NARROW [EC:2.7.4.3] +xref: EC:2.7.4.3 +xref: MetaCyc:ADENYL-KIN-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019201 ! nucleotide kinase activity + +[Term] +id: GO:0004018 +name: adenylosuccinate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] +subset: gosubset_prok +synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] +synonym: "adenylosuccinase activity" EXACT [EC:4.3.2.2] +synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] +synonym: "succino AMP-lyase activity" EXACT [EC:4.3.2.2] +xref: EC:4.3.2.2 +xref: MetaCyc:AMPSYN-RXN +xref: Reactome:7065 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0004019 +name: adenylosuccinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP." [EC:6.3.4.4] +subset: gosubset_prok +synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] +synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] +synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] +synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] +synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] +xref: EC:6.3.4.4 +xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN +xref: Reactome:7069 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004020 +name: adenylylsulfate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] +subset: gosubset_prok +synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] +synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] +synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] +synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] +synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] +synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] +synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] +synonym: "adenylyl-sulfate kinase activity" EXACT [] +synonym: "adenylyl-sulphate kinase activity" EXACT [] +synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] +synonym: "APS kinase activity" EXACT [EC:2.7.1.25] +synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] +xref: EC:2.7.1.25 +xref: MetaCyc:ADENYLYLSULFKIN-RXN +xref: Reactome:7077 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004021 +name: alanine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate." [EC:2.6.1.2] +subset: gosubset_prok +synonym: "alanine aminotransferase activity" EXACT [] +synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "ALT" RELATED [EC:2.6.1.2] +synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] +synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] +synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] +synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] +synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "GPT" RELATED [EC:2.6.1.2] +synonym: "L-alanine aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "L-alanine transaminase activity" EXACT [EC:2.6.1.2] +synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "L-alanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "pyruvate transaminase activity" EXACT [EC:2.6.1.2] +synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] +synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] +xref: EC:2.6.1.2 +xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN +xref: Reactome:7079 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004022 +name: alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] +subset: gosubset_prok +synonym: "ADH" RELATED [EC:1.1.1.1] +synonym: "alcohol dehydrogenase (NAD) activity" NARROW [] +synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] +synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] +synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] +synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] +synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] +synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] +synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] +synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] +synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] +xref: EC:1.1.1.1 +xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN +xref: UM-BBD_enzymeID:e0023 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004023 +name: alcohol dehydrogenase activity, metal ion-independent +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] +is_a: GO:0004022 ! alcohol dehydrogenase activity + +[Term] +id: GO:0004024 +name: alcohol dehydrogenase activity, zinc-dependent +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] +subset: gosubset_prok +xref: Reactome:7085 +is_a: GO:0004022 ! alcohol dehydrogenase activity + +[Term] +id: GO:0004025 +name: alcohol dehydrogenase activity, iron-dependent +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] +subset: gosubset_prok +is_a: GO:0004022 ! alcohol dehydrogenase activity + +[Term] +id: GO:0004026 +name: alcohol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] +synonym: "AATASE activity" EXACT [EC:2.3.1.84] +synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] +synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] +xref: EC:2.3.1.84 +xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity + +[Term] +id: GO:0004027 +name: alcohol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] +subset: gosubset_prok +synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "alcohol sulphotransferase activity" EXACT [] +synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] +synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] +synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] +synonym: "HST" RELATED [EC:2.8.2.2] +synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] +synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] +synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] +synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] +synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] +xref: EC:2.8.2.2 +xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN +xref: Reactome:7092 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0004028 +name: 3-chloroallyl aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] +subset: gosubset_prok +xref: EC:1.2.1.- +xref: Reactome:7095 +xref: UM-BBD_enzymeID:e0432 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004029 +name: aldehyde dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] +subset: gosubset_prok +synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] +synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] +synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] +synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] +synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] +synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] +synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] +synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] +synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] +xref: EC:1.2.1.3 +xref: MetaCyc:ALDHDEHYDROG-RXN +xref: Reactome:7097 +xref: UM-BBD_enzymeID:e0024 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004030 +name: aldehyde dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] +subset: gosubset_prok +synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] +synonym: "ALDH" RELATED [EC:1.2.1.5] +xref: EC:1.2.1.5 +xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-(NAD(P)+)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004031 +name: aldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + H2O2." [EC:1.2.3.1] +subset: gosubset_prok +synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] +synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] +xref: EC:1.2.3.1 +xref: MetaCyc:ALDEHYDE-OXIDASE-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0004032 +name: aldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] +subset: gosubset_prok +synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] +synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] +xref: EC:1.1.1.21 +xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN +is_a: GO:0004033 ! aldo-keto reductase activity + +[Term] +id: GO:0004033 +name: aldo-keto reductase activity +namespace: molecular_function +def: "Catalysis of the NADPH-dependent reduction of carbonyl compounds." [GOC:jl, PMID:2498333] +subset: gosubset_prok +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004034 +name: aldose 1-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] +subset: gosubset_prok +synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] +synonym: "mutarotase activity" RELATED [EC:5.1.3.3] +xref: EC:5.1.3.3 +xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0004035 +name: alkaline phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] +subset: gosubset_prok +synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] +synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] +synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] +synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] +synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] +synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] +synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] +xref: EC:3.1.3.1 +xref: MetaCyc:ALKAPHOSPHA-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004037 +name: allantoicase activity +namespace: molecular_function +def: "Catalysis of the reaction: allantoate + H2O = (-)-ureidoglycolate + urea." [EC:3.5.3.4] +subset: gosubset_prok +synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] +synonym: "allantoine amidinohydrolase activity" EXACT [] +xref: EC:3.5.3.4 +xref: MetaCyc:ALLANTOICASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004038 +name: allantoinase activity +namespace: molecular_function +def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] +subset: gosubset_prok +synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] +xref: EC:3.5.2.5 +xref: MetaCyc:ALLANTOINASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0004039 +name: allophanate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: urea-1-carboxylate + H2O = 2 CO2 + 2 NH3." [EC:3.5.1.54] +subset: gosubset_prok +synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] +synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] +xref: EC:3.5.1.54 +xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN +xref: UM-BBD_enzymeID:e0534 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004040 +name: amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] +subset: gosubset_prok +synonym: "acetamidase activity" EXACT [] +synonym: "acylamidase activity" EXACT [EC:3.5.1.4] +synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] +synonym: "acylase activity" EXACT [EC:3.5.1.4] +synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] +synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] +synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] +xref: EC:3.5.1.4 +xref: MetaCyc:AMIDASE-RXN +xref: UM-BBD_enzymeID:e0068 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004042 +name: amino-acid N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate." [EC:2.3.1.1] +subset: gosubset_prok +synonym: "acetyl-CoA:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.1] +synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] +synonym: "AGAS" RELATED [EC:2.3.1.1] +synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] +synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] +xref: EC:2.3.1.1 +xref: MetaCyc:N-ACETYLTRANSFER-RXN +xref: Reactome:7143 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004043 +name: L-aminoadipate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] +subset: gosubset_prok +synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] +synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] +synonym: "AAR" EXACT [EC:1.2.1.31] +synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] +synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] +synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] +synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] +synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] +synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] +synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] +synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] +xref: EC:1.2.1.31 +xref: MetaCyc:1.2.1.31-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004044 +name: amidophosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O." [EC:2.4.2.14] +subset: gosubset_prok +synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] +synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] +synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] +xref: EC:2.4.2.14 +xref: MetaCyc:PRPPAMIDOTRANS-RXN +xref: Reactome:7147 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004045 +name: aminoacyl-tRNA hydrolase activity +namespace: molecular_function +alt_id: GO:0019850 +def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] +subset: gosubset_prok +synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] +synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] +synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] +synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] +synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] +xref: EC:3.1.1.29 +xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0004046 +name: aminoacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] +subset: gosubset_prok +synonym: "acylase I activity" NARROW [EC:3.5.1.14] +synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] +synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] +synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] +synonym: "benzamidase activity" RELATED [EC:3.5.1.14] +synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] +synonym: "hippurase activity" EXACT [EC:3.5.1.14] +synonym: "histozyme activity" RELATED [EC:3.5.1.14] +synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] +synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] +synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] +synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] +synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] +xref: EC:3.5.1.14 +xref: MetaCyc:AMINOACYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004047 +name: aminomethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] +subset: gosubset_prok +synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] +synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] +synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] +synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] +synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] +synonym: "T-protein" RELATED [EC:2.1.2.10] +synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] +xref: EC:2.1.2.10 +xref: MetaCyc:GCVT-RXN +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0004048 +name: anthranilate phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate." [EC:2.4.2.18] +subset: gosubset_prok +synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] +synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] +synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] +synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] +synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] +synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] +synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] +synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] +synonym: "PRT" RELATED [EC:2.4.2.18] +xref: EC:2.4.2.18 +xref: MetaCyc:PRTRANS-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004049 +name: anthranilate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] +subset: gosubset_prok +synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] +synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] +xref: EC:4.1.3.27 +xref: MetaCyc:ANTHRANSYN-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0004050 +name: apyrase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] +comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. +is_obsolete: true +consider: GO:0017110 +consider: GO:0017111 + +[Term] +id: GO:0004051 +name: arachidonate 5-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] +subset: gosubset_prok +synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] +synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] +synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] +synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] +synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] +synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] +synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] +synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] +synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] +synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] +synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] +xref: EC:1.13.11.34 +xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004052 +name: arachidonate 12-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31] +synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] +synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] +synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] +synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] +synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] +synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] +synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] +synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] +xref: EC:1.13.11.31 +xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004053 +name: arginase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] +subset: gosubset_prok +synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] +synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] +synonym: "canavanase activity" EXACT [EC:3.5.3.1] +synonym: "L-arginase activity" EXACT [EC:3.5.3.1] +synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] +xref: EC:3.5.3.1 +xref: MetaCyc:ARGINASE-RXN +xref: Reactome:7167 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004054 +name: arginine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-arginine = ADP + N-phospho-L-arginine." [EC:2.7.3.3] +synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] +synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] +synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] +synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] +xref: EC:2.7.3.3 +xref: MetaCyc:ARGININE-KINASE-RXN +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004055 +name: argininosuccinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] +subset: gosubset_prok +synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] +synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] +synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] +synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] +synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] +synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] +xref: EC:6.3.4.5 +xref: MetaCyc:ARGSUCCINSYN-RXN +xref: Reactome:7171 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004056 +name: argininosuccinate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] +subset: gosubset_prok +synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] +synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] +synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] +synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] +synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] +synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] +synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] +xref: EC:4.3.2.1 +xref: MetaCyc:ARGSUCCINLYA-RXN +xref: Reactome:7173 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0004057 +name: arginyltransferase activity +namespace: molecular_function +alt_id: GO:0042172 +def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] +subset: gosubset_prok +synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] +synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] +synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] +synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] +synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] +synonym: "arginyl-tRNA-protein transferase activity" EXACT [] +synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] +xref: EC:2.3.2.8 +xref: MetaCyc:ARGINYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0004058 +name: aromatic-L-amino-acid decarboxylase activity +namespace: molecular_function +alt_id: GO:0016400 +def: "Catalysis of the reaction: L-tryptophan = tryptamine + CO2." [EC:4.1.1.28] +synonym: "5-hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] +synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] +synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" EXACT [EC:4.1.1.28] +synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] +synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28] +synonym: "hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] +synonym: "L-DOPA decarboxylase activity" EXACT [EC:4.1.1.28] +synonym: "tryptophan decarboxylase activity" EXACT [EC:4.1.1.28] +xref: EC:4.1.1.28 +xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004059 +name: aralkylamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] +synonym: "AANAT activity" EXACT [EC:2.3.1.87] +synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] +synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] +synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] +synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] +synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] +synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] +xref: EC:2.3.1.87 +xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004060 +name: arylamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] +subset: gosubset_prok +synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] +synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] +synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] +xref: EC:2.3.1.5 +xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN +xref: Reactome:7187 +xref: UM-BBD_enzymeID:e0341 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004061 +name: arylformamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] +subset: gosubset_prok +synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] +synonym: "formamidase I" RELATED [EC:3.5.1.9] +synonym: "formamidase II" RELATED [EC:3.5.1.9] +synonym: "formylase activity" EXACT [EC:3.5.1.9] +synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] +synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] +synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] +xref: EC:3.5.1.9 +xref: MetaCyc:ARYLFORMAMIDASE-RXN +xref: Reactome:7190 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004062 +name: aryl sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] +subset: gosubset_prok +synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] +synonym: "aryl sulphotransferase activity" EXACT [] +synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] +synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] +synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "PST" RELATED [EC:2.8.2.1] +synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] +synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] +xref: EC:2.8.2.1 +xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN +xref: Reactome:7193 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0004063 +name: aryldialkylphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] +subset: gosubset_prok +synonym: "A-esterase activity" BROAD [EC:3.1.8.1] +synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] +synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] +synonym: "esterase B1" RELATED [EC:3.1.8.1] +synonym: "esterase E4" RELATED [EC:3.1.8.1] +synonym: "OPH" RELATED [EC:3.1.8.1] +synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] +synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] +synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] +synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] +synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] +synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] +synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] +synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] +synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] +xref: EC:3.1.8.1 +xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN +xref: UM-BBD_enzymeID:e0054 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004064 +name: arylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] +subset: gosubset_prok +synonym: "A-esterase activity" BROAD [EC:3.1.1.2] +synonym: "aromatic esterase" NARROW [EC:3.1.1.2] +synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] +synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] +xref: EC:3.1.1.2 +xref: MetaCyc:ARYLESTERASE-RXN +xref: UM-BBD_enzymeID:e0535 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0004065 +name: arylsulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate)." [EC:3.1.6.1] +subset: gosubset_prok +synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] +synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] +synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] +synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] +synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] +synonym: "arylsulphatase activity" EXACT [] +synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] +synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] +synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] +synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] +synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] +synonym: "sulfatase activity" RELATED [EC:3.1.6.1] +xref: EC:3.1.6.1 +xref: MetaCyc:ARYLSULFAT-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004066 +name: asparagine synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] +subset: gosubset_prok +synonym: "AS" RELATED [EC:6.3.5.4] +synonym: "AS-B activity" EXACT [EC:6.3.5.4] +synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] +synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] +synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] +synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] +synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] +synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] +xref: EC:6.3.5.4 +xref: MetaCyc:ASNSYNB-RXN +xref: Reactome:7213 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0004067 +name: asparaginase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] +subset: gosubset_prok +synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] +synonym: "asparaginase II" RELATED [EC:3.5.1.1] +synonym: "colaspase activity" EXACT [EC:3.5.1.1] +synonym: "crasnitin" RELATED [EC:3.5.1.1] +synonym: "elspar" RELATED [EC:3.5.1.1] +synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] +synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] +synonym: "leunase activity" EXACT [EC:3.5.1.1] +xref: EC:3.5.1.1 +xref: MetaCyc:ASPARAGHYD-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004068 +name: aspartate 1-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] +subset: gosubset_prok +synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] +synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] +synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] +synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] +synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] +xref: EC:4.1.1.11 +xref: MetaCyc:ASPDECARBOX-RXN +xref: MetaCyc:PWY-5155 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004069 +name: aspartate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] +subset: gosubset_prok +synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "AAT" RELATED [EC:2.6.1.1] +synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] +synonym: "aspartate aminotransferase activity" EXACT [] +synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] +synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "aspartic acid aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "aspartic aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "aspartyl aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "AspT" RELATED [EC:2.6.1.1] +synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] +synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] +synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] +synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] +synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] +synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] +synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] +synonym: "L-aspartate transaminase activity" EXACT [EC:2.6.1.1] +synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] +synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] +synonym: "L-aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "L-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] +synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] +synonym: "transaminase A activity" EXACT [EC:2.6.1.1] +xref: EC:2.6.1.1 +xref: MetaCyc:ASPAMINOTRANS-RXN +xref: Reactome:7220 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004070 +name: aspartate carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate." [EC:2.1.3.2] +subset: gosubset_prok +synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] +synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] +synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] +synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] +synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] +synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] +synonym: "ATCase activity" EXACT [EC:2.1.3.2] +synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] +synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] +synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] +synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] +synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] +xref: EC:2.1.3.2 +xref: MetaCyc:ASPCARBTRANS-RXN +xref: Reactome:7225 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0004071 +name: aspartate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] +subset: gosubset_prok +synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] +synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] +synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] +xref: EC:6.3.1.1 +xref: MetaCyc:ASNSYNA-RXN +is_a: GO:0016211 ! ammonia ligase activity + +[Term] +id: GO:0004072 +name: aspartate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate." [EC:2.7.2.4] +subset: gosubset_prok +synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] +synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] +synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] +synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] +xref: EC:2.7.2.4 +xref: MetaCyc:ASPARTATEKIN-RXN +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004073 +name: aspartate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+." [EC:1.2.1.11] +subset: gosubset_prok +synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] +synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] +synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] +synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] +synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] +synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] +synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] +xref: EC:1.2.1.11 +xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004074 +name: biliverdin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] +synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] +xref: EC:1.3.1.24 +xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004075 +name: biotin carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] +subset: gosubset_prok +synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] +synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] +xref: EC:6.3.4.14 +xref: MetaCyc:BIOTIN-CARBOXYL-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004076 +name: biotin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: dethiobiotin + sulfur = biotin." [EC:2.8.1.6] +subset: gosubset_prok +synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] +synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] +xref: EC:2.8.1.6 +xref: MetaCyc:2.8.1.6-RXN +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0004077 +name: biotin-[acetyl-CoA-carboxylase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] +subset: gosubset_prok +synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] +synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] +synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] +synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] +synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] +synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] +synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] +synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] +synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] +synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] +synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] +synonym: "HCS" RELATED [EC:6.3.4.15] +xref: EC:6.3.4.15 +xref: MetaCyc:BIOTINLIG-RXN +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004078 +name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] +synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] +synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] +synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] +synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] +synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] +synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] +synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11] +xref: EC:6.3.4.11 +xref: MetaCyc:6.3.4.11-RXN +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004079 +name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] +synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] +synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] +synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] +synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] +synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] +synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] +synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] +synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] +synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] +xref: EC:6.3.4.9 +xref: MetaCyc:6.3.4.9-RXN +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004080 +name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] +synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] +synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] +synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] +synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] +synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] +synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] +synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] +synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] +xref: EC:6.3.4.10 +xref: MetaCyc:6.3.4.10-RXN +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004081 +name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity +namespace: molecular_function +def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] +subset: gosubset_prok +synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] +synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] +synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] +synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] +synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] +synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] +synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] +synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] +synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] +synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] +synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] +synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] +synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] +synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] +xref: EC:3.6.1.17 +xref: MetaCyc:3.6.1.17-RXN +is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity + +[Term] +id: GO:0004082 +name: bisphosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] +synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] +synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] +synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] +synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] +synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] +synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] +synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] +synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] +synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] +synonym: "BPGM activity" EXACT [EC:5.4.2.4] +synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] +synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] +synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] +synonym: "DPGM" RELATED [EC:5.4.2.4] +synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] +xref: EC:5.4.2.4 +xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004083 +name: bisphosphoglycerate 2-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate." [EC:3.1.3.13] +synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" EXACT [EC:3.1.3.13] +xref: EC:3.1.3.13 +xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN +is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity + +[Term] +id: GO:0004084 +name: branched-chain-amino-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine." [EC:2.6.1.42, GOC:mah] +subset: gosubset_prok +synonym: "branched-chain amino acid aminotransferase activity" EXACT [] +synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] +synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] +synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] +synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] +synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] +synonym: "transaminase B activity" RELATED [EC:2.6.1.42] +xref: EC:2.6.1.42 +xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN +xref: Reactome:70697 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004085 +name: butyryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + ETF = 2-butenoyl-CoA + reduced ETF." [EC:1.3.99.2] +subset: gosubset_prok +synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.99.2] +synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] +synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] +synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] +synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.99.2] +synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.99.2] +synonym: "ethylene reductase activity" EXACT [EC:1.3.99.2] +synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.2] +synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] +synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.2] +synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.99.2] +synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.99.2] +xref: EC:1.3.99.2 +xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0034 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0004086 +name: carbamoyl-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] +subset: gosubset_prok +synonym: "carbamoyl phosphate synthase activity" EXACT [] +xref: EC:6.3.-.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004087 +name: carbamoyl-phosphate synthase (ammonia) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate." [EC:6.3.4.16] +subset: gosubset_prok +synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] +synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] +synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] +synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] +synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] +synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] +synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] +synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] +synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] +synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] +synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] +synonym: "CPS I activity" NARROW [EC:6.3.4.16] +xref: EC:6.3.4.16 +xref: MetaCyc:6.3.4.16-RXN +xref: Reactome:7296 +is_a: GO:0004086 ! carbamoyl-phosphate synthase activity + +[Term] +id: GO:0004088 +name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] +subset: gosubset_prok +synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] +synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] +synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] +synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] +synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] +synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] +synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] +synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] +synonym: "CPS activity" EXACT [EC:6.3.5.5] +synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] +synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] +synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] +synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] +xref: EC:6.3.5.5 +xref: MetaCyc:CARBPSYN-RXN +xref: Reactome:7299 +is_a: GO:0004086 ! carbamoyl-phosphate synthase activity +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0004089 +name: carbonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] +subset: gosubset_prok +synonym: "anhydrase activity" EXACT [EC:4.2.1.1] +synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] +synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] +synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] +synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] +synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] +synonym: "carbonic anhydrase activity" EXACT [] +synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] +synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] +xref: EC:4.2.1.1 +xref: MetaCyc:CARBODEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004090 +name: carbonyl reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] +subset: gosubset_prok +synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] +synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] +synonym: "ALR3" RELATED [EC:1.1.1.184] +synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] +synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] +synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] +synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] +synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] +synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] +synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] +xref: EC:1.1.1.184 +xref: MetaCyc:CARBONYL-REDUCTASE-(NADPH)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004091 +name: carboxylesterase activity +namespace: molecular_function +alt_id: GO:0004302 +alt_id: GO:0004759 +alt_id: GO:0016789 +def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1] +subset: gosubset_prok +synonym: "Ali-esterase activity" RELATED [EC:3.1.1] +synonym: "ali-esterase activity" EXACT [EC:3.1.1] +synonym: "alpha-carboxylesterase activity" EXACT [EC:3.1.1] +synonym: "B-esterase activity" RELATED [EC:3.1.1] +synonym: "carboxyesterase activity" EXACT [EC:3.1.1] +synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1] +synonym: "carboxylate esterase activity" EXACT [EC:3.1.1] +synonym: "carboxylic acid esterase activity" EXACT [] +synonym: "carboxylic ester hydrolase activity" EXACT [] +synonym: "carboxylic esterase activity" EXACT [EC:3.1.1] +synonym: "carboxylic-ester hydrolase activity" EXACT [EC:3.1.1] +synonym: "cocaine esterase activity" NARROW [EC:3.1.1] +synonym: "esterase A" RELATED [EC:3.1.1] +synonym: "esterase B" RELATED [EC:3.1.1] +synonym: "nonspecific carboxylesterase activity" EXACT [EC:3.1.1] +synonym: "procaine esterase activity" NARROW [EC:3.1.1] +synonym: "serine esterase activity" EXACT [] +synonym: "triacetin esterase" NARROW [EC:3.1.1] +synonym: "vitamin A esterase" NARROW [EC:3.1.1] +xref: EC:3.1.1 +xref: EC:3.1.1.1 +xref: MetaCyc:CARBOXYLESTERASE-RXN +xref: UM-BBD_enzymeID:e0631 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0004092 +name: carnitine O-acetyltransferase activity +namespace: molecular_function +alt_id: GO:0004093 +alt_id: GO:0004094 +def: "Catalysis of the reaction: acetyl-CoA + carnitine = CoA + O-acetylcarnitine." [EC:2.3.1.7] +subset: gosubset_prok +synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] +synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] +synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] +synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] +synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] +synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] +synonym: "carnitine O-acetyltransferase I activity" NARROW [] +synonym: "carnitine O-acetyltransferase II activity" NARROW [] +synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] +synonym: "CATC" RELATED [EC:2.3.1.7] +xref: EC:2.3.1.7 +xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016406 ! carnitine O-acyltransferase activity +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0004095 +name: carnitine O-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] +synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] +synonym: "CPT" RELATED [EC:2.3.1.21] +synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] +synonym: "CPT-A" RELATED [EC:2.3.1.21] +synonym: "CPT-B" RELATED [EC:2.3.1.21] +synonym: "CPTi" RELATED [EC:2.3.1.21] +synonym: "CPTo" RELATED [EC:2.3.1.21] +synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] +synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] +synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] +synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] +xref: EC:2.3.1.21 +xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN +is_a: GO:0016406 ! carnitine O-acyltransferase activity +is_a: GO:0016416 ! O-palmitoyltransferase activity + +[Term] +id: GO:0004096 +name: catalase activity +namespace: molecular_function +alt_id: GO:0016952 +alt_id: GO:0016953 +def: "Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O." [EC:1.11.1.6] +subset: gosubset_prok +synonym: "bacterial catalase-peroxidase activity" NARROW [] +synonym: "caperase activity" EXACT [EC:1.11.1.6] +synonym: "CAT" RELATED [EC:1.11.1.6] +synonym: "catalase reaction" EXACT [] +synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] +synonym: "equilase activity" EXACT [EC:1.11.1.6] +synonym: "haem catalase activity" NARROW [] +synonym: "heme catalase activity" NARROW [] +synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] +synonym: "manganese catalase activity" NARROW [] +synonym: "optidase activity" EXACT [EC:1.11.1.6] +xref: EC:1.11.1.6 +xref: MetaCyc:CATAL-RXN +xref: Reactome:76029 +xref: UM-BBD_enzymeID:e0834 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004097 +name: catechol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] +subset: gosubset_prok +synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] +synonym: "catecholase" BROAD [EC:1.10.3.1] +synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] +synonym: "dopa oxidase" BROAD [EC:1.10.3.1] +synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] +synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] +synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] +synonym: "phenolase activity" BROAD [EC:1.10.3.1] +synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] +synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] +synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] +xref: EC:1.10.3.1 +xref: MetaCyc:CATECHOL-OXIDASE-RXN +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0004098 +name: cerebroside-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + SO4(2-) (sulfate)." [EC:3.1.6.8] +subset: gosubset_prok +synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] +synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] +synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] +synonym: "cerebroside-sulphatase activity" EXACT [] +xref: EC:3.1.6.8 +xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004099 +name: chitin deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] +subset: gosubset_prok +synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] +xref: EC:3.5.1.41 +xref: MetaCyc:CHITIN-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0004100 +name: chitin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1)." [EC:2.4.1.16] +subset: gosubset_prok +synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] +synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] +synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] +synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] +synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] +synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] +xref: EC:2.4.1.16 +xref: MetaCyc:CHITIN-SYNTHASE-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0004102 +name: choline O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + choline = CoA + O-acetylcholine." [EC:2.3.1.6] +subset: gosubset_prok +synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] +synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] +synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] +synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] +xref: EC:2.3.1.6 +xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0004103 +name: choline kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + choline = ADP + O-phosphocholine." [EC:2.7.1.32] +subset: gosubset_prok +synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] +synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] +synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] +synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] +xref: EC:2.7.1.32 +xref: MetaCyc:CHOLINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004104 +name: cholinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] +subset: gosubset_prok +synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] +synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] +synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] +synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] +synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] +synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] +synonym: "choline esterase activity" EXACT [EC:3.1.1.8] +synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] +synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] +synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] +synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] +xref: EC:3.1.1.8 +xref: MetaCyc:CHOLINESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0004105 +name: choline-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] +subset: gosubset_prok +synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] +synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] +synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] +synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] +synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] +synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] +synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] +synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] +synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] +synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] +synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] +synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] +xref: EC:2.7.7.15 +xref: MetaCyc:2.7.7.15-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004106 +name: chorismate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5] +subset: gosubset_prok +synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] +synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] +xref: EC:5.4.99.5 +xref: MetaCyc:CHORISMATEMUT-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0004107 +name: chorismate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5] +subset: gosubset_prok +synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] +synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] +synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] +xref: EC:4.2.3.5 +xref: MetaCyc:CHORISMATE-SYNTHASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0004108 +name: citrate (Si)-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [EC:2.3.3.1] +comment: Note that this function was formerly EC:4.1.3.7. +subset: gosubset_prok +synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] +synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] +synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] +synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] +synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] +synonym: "citric synthase activity" EXACT [EC:2.3.3.1] +synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] +synonym: "citrogenase activity" EXACT [EC:2.3.3.1] +synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] +synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] +synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] +xref: EC:2.3.3.1 +xref: MetaCyc:CITSYN-RXN +xref: Reactome:8157 +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004109 +name: coproporphyrinogen oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O." [EC:1.3.3.3] +subset: gosubset_prok +synonym: "coprogen oxidase activity" EXACT [] +synonym: "coproporphyrinogen-III oxidase activity" EXACT [] +synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] +synonym: "coproporphyrinogenase activity" EXACT [] +xref: EC:1.3.3.3 +xref: MetaCyc:RXN0-1461 +xref: Reactome:8160 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0004110 +name: corticosteroid side-chain-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21] +synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] +synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] +xref: EC:5.3.1.21 +xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004111 +name: creatine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + creatine = ADP + phosphocreatine." [EC:2.7.3.2] +synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] +synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] +synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] +synonym: "BB-CK" RELATED [EC:2.7.3.2] +synonym: "CK" RELATED [EC:2.7.3.2] +synonym: "CK-BB" RELATED [EC:2.7.3.2] +synonym: "CK-MB" RELATED [EC:2.7.3.2] +synonym: "CK-MM" RELATED [EC:2.7.3.2] +synonym: "CKMiMi" RELATED [EC:2.7.3.2] +synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] +synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] +synonym: "MB-CK" RELATED [EC:2.7.3.2] +synonym: "Mi-CK" RELATED [EC:2.7.3.2] +synonym: "MiMi-CK" RELATED [EC:2.7.3.2] +synonym: "MM-CK" RELATED [EC:2.7.3.2] +synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] +xref: EC:2.7.3.2 +xref: MetaCyc:CREATINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0004112 +name: cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] +subset: gosubset_prok +xref: EC:3.1.4.- +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004113 +name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] +subset: gosubset_prok +synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] +synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] +synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] +synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] +synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] +synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] +synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] +synonym: "CNPase activity" EXACT [EC:3.1.4.37] +synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] +synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] +synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] +synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] +xref: EC:3.1.4.37 +xref: MetaCyc:3.1.4.37-RXN +is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004114 +name: 3',5'-cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] +subset: gosubset_prok +synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] +synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] +synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] +synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] +synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] +synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] +synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] +synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] +synonym: "PDE" RELATED [EC:3.1.4.17] +xref: EC:3.1.4.17 +xref: MetaCyc:3.1.4.17-RXN +is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004115 +name: 3',5'-cyclic-AMP phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] +subset: gosubset_prok +synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] +synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] +synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] +synonym: "cAMP-specific phosphodiesterase activity" EXACT [] +synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.- +xref: Reactome:8212 +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004117 +name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] +xref: EC:3.1.4.- +xref: Reactome:8219 +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004118 +name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] +xref: EC:3.1.4.- +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004119 +name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] +xref: EC:3.1.4.- +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004120 +name: photoreceptor cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of bonds in a cyclic nucleotide (nucleoside cyclic phosphate + H2O = nucleoside phosphate)." [EC:3.1.4.-] +xref: EC:3.1.4.- +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004121 +name: cystathionine beta-lyase activity +namespace: molecular_function +alt_id: GO:0008799 +def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] +subset: gosubset_prok +synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] +synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] +synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] +synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] +synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] +synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] +xref: EC:4.4.1.8 +xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004122 +name: cystathionine beta-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] +subset: gosubset_prok +synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] +synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] +synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] +synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] +synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] +synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] +xref: EC:4.2.1.22 +xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004123 +name: cystathionine gamma-lyase activity +namespace: molecular_function +alt_id: GO:0016225 +def: "Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate." [EC:4.4.1.1] +subset: gosubset_prok +synonym: "cystalysin" RELATED [EC:4.4.1.1] +synonym: "cystathionase activity" EXACT [EC:4.4.1.1] +synonym: "cystathioninase activity" EXACT [EC:4.4.1.1] +synonym: "cysteine desulfhydrase activity" EXACT [] +synonym: "cystine desulfhydrase activity" EXACT [EC:4.4.1.1] +synonym: "gamma-CTL" RELATED [EC:4.4.1.1] +synonym: "gamma-cystathionase activity" EXACT [EC:4.4.1.1] +synonym: "homoserine deaminase activity" EXACT [EC:4.4.1.1] +synonym: "homoserine deaminase-cystathionase activity" EXACT [EC:4.4.1.1] +synonym: "homoserine dehydratase activity" EXACT [EC:4.4.1.1] +synonym: "L-cystathionine cysteine-lyase (deaminating)" EXACT [EC:4.4.1.1] +synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] +xref: EC:4.4.1.1 +xref: MetaCyc:CYSTAGLY-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004124 +name: cysteine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate." [EC:4.2.99.8] +comment: Note that this function was formerly 4.2.99.8. +subset: gosubset_prok +synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] +synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] +synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] +synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] +synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] +synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] +synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] +synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] +synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] +synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] +synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] +xref: EC:2.5.1.47 +xref: MetaCyc:ACSERLY-RXN +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0004125 +name: L-seryl-tRNASec selenium transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] +subset: gosubset_prok +synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] +synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] +synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] +synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] +synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] +synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] +synonym: "selenocysteine synthase activity" EXACT [] +synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] +synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] +xref: EC:2.9.1.1 +xref: MetaCyc:2.9.1.1-RXN +is_a: GO:0016786 ! selenotransferase activity + +[Term] +id: GO:0004126 +name: cytidine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] +subset: gosubset_prok +synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] +synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] +xref: EC:3.5.4.5 +xref: MetaCyc:CYTIDEAM2-RXN +xref: Reactome:8270 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004127 +name: cytidylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] +subset: gosubset_prok +synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] +synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] +synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] +synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] +synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] +synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] +synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] +synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] +synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] +synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] +xref: EC:2.7.4.14 +xref: MetaCyc:CMPKI-RXN +is_a: GO:0019201 ! nucleotide kinase activity + +[Term] +id: GO:0004128 +name: cytochrome-b5 reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] +synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] +synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] +synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] +synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] +synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] +synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] +synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] +synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] +xref: EC:1.6.2.2 +xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN +is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor + +[Term] +id: GO:0004129 +name: cytochrome-c oxidase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +subset: gosubset_prok +synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] +synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] +synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] +synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] +synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] +synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] +synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] +synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] +synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] +synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] +synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] +synonym: "indophenolase" NARROW [EC:1.9.3.1] +synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] +synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] +xref: EC:1.9.3.1 +xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN +xref: Reactome:8283 +is_a: GO:0015002 ! heme-copper terminal oxidase activity +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0016676 ! oxidoreductase activity, acting on heme group of donors, oxygen as acceptor + +[Term] +id: GO:0004130 +name: cytochrome-c peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] +subset: gosubset_prok +synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] +synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] +synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] +synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] +synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] +synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] +synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] +synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] +synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] +xref: EC:1.11.1.5 +xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004131 +name: cytosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] +subset: gosubset_prok +synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] +synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] +xref: EC:3.5.4.1 +xref: MetaCyc:CYTDEAM-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004132 +name: dCMP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] +subset: gosubset_prok +synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] +synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] +synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] +synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] +synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] +synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] +synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] +xref: EC:3.5.4.12 +xref: MetaCyc:DCMP-DEAMINASE-RXN +xref: Reactome:8340 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004133 +name: glycogen debranching enzyme activity +namespace: molecular_function +def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0004134 +name: 4-alpha-glucanotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan." [EC:2.4.1.25] +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] +synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] +synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] +synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] +synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] +synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] +synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] +synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] +xref: EC:2.4.1.25 +xref: MetaCyc:2.4.1.25-RXN +xref: Reactome:8344 +is_a: GO:0004133 ! glycogen debranching enzyme activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0004135 +name: amylo-alpha-1,6-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "amylo-1,6-glucosidase activity" EXACT [] +synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] +synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] +synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] +synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] +xref: EC:3.2.1.33 +xref: MetaCyc:3.2.1.33-RXN +xref: Reactome:8347 +is_a: GO:0004133 ! glycogen debranching enzyme activity +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004136 +name: deoxyadenosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP." [EC:2.7.1.76] +subset: gosubset_prok +synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] +synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] +synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] +xref: EC:2.7.1.76 +xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004137 +name: deoxycytidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] +subset: gosubset_prok +synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] +synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] +synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] +synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] +synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] +synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] +xref: EC:2.7.1.74 +xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004138 +name: deoxyguanosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deoxyguanosine = ADP + dGMP." [EC:2.7.1.113] +subset: gosubset_prok +synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] +synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] +synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] +synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] +synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] +xref: EC:2.7.1.113 +xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004139 +name: deoxyribose-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4] +subset: gosubset_prok +synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] +synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] +synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] +synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] +synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] +synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] +xref: EC:4.1.2.4 +xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004140 +name: dephospho-CoA kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA." [EC:2.7.1.24] +subset: gosubset_prok +synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] +synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] +synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] +synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] +xref: EC:2.7.1.24 +xref: MetaCyc:DEPHOSPHOCOAKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004141 +name: dethiobiotin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin." [EC:6.3.3.3] +subset: gosubset_prok +synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] +synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] +synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] +xref: EC:6.3.3.3 +xref: MetaCyc:DETHIOBIOTIN-SYN-RXN +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0004142 +name: diacylglycerol cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] +synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "CPT" RELATED [EC:2.7.8.2] +synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] +synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] +synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] +synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] +synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] +synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] +xref: EC:2.7.8.2 +xref: MetaCyc:2.7.8.2-RXN +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0004143 +name: diacylglycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate." [EC:2.7.1.107, GOC:elh] +subset: gosubset_prok +synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] +synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] +synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] +synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] +synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] +synonym: "CTP:diacylglycerol kinase activity" NARROW [] +synonym: "DG kinase activity" EXACT [EC:2.7.1.107] +synonym: "DGK activity" EXACT [EC:2.7.1.107] +synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] +synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] +synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] +xref: EC:2.7.1.107 +xref: MetaCyc:DIACYLGLYKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004144 +name: diacylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] +subset: gosubset_prok +synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] +synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] +synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] +synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] +synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] +synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] +xref: EC:2.3.1.20 +xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN +xref: Reactome:8383 +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0004145 +name: diamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] +subset: gosubset_prok +synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] +synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] +synonym: "diamine acetyltransferase activity" EXACT [] +synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] +synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] +synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] +synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] +synonym: "spermine acetyltransferase" NARROW [] +synonym: "spermine N(1)-acetyltransferase" NARROW [] +synonym: "spermine N-acetyltransferase" RELATED [] +xref: EC:2.3.1.57 +xref: MetaCyc:DIAMACTRANS-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004146 +name: dihydrofolate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] +subset: gosubset_prok +synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] +synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] +synonym: "DHFR" RELATED [EC:1.5.1.3] +synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] +synonym: "dihydrofolate reduction" EXACT [] +synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] +synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] +synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] +synonym: "folic reductase activity" EXACT [EC:1.5.1.3] +synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] +synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] +synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] +synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] +xref: EC:1.5.1.3 +xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004147 +name: dihydrolipoamide branched chain acyltransferase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] +xref: EC:2.3.1.- +xref: Reactome:8394 +is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity + +[Term] +id: GO:0004148 +name: dihydrolipoyl dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] +subset: gosubset_prok +synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "diaphorase activity" EXACT [EC:1.8.1.4] +synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] +synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] +synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] +synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] +synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] +synonym: "L-protein activity" RELATED [EC:1.8.1.4] +synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] +synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] +synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] +synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] +synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] +synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] +synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] +synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] +synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] +xref: EC:1.8.1.4 +xref: MetaCyc:DIHYDLIPOXN-RXN +xref: Reactome:8399 +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004149 +name: dihydrolipoyllysine-residue succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] +subset: gosubset_prok +synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] +synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] +synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] +synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] +synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] +synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] +synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] +synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] +synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] +synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] +synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] +synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] +synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] +synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] +xref: EC:2.3.1.61 +xref: MetaCyc:DIHYDLIPSUCCTRANS-RXN +xref: Reactome:8404 +is_a: GO:0016751 ! S-succinyltransferase activity + +[Term] +id: GO:0004150 +name: dihydroneopterin aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] +subset: gosubset_prok +synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] +synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] +xref: EC:4.1.2.25 +xref: MetaCyc:H2NEOPTERINALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004151 +name: dihydroorotase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.3] +subset: gosubset_prok +synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] +synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] +synonym: "DHOase activity" EXACT [EC:3.5.2.3] +synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] +xref: EC:3.5.2.3 +xref: MetaCyc:DIHYDROOROT-RXN +xref: Reactome:8410 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0004152 +name: dihydroorotate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor." [EC:1.3.99.11] +subset: gosubset_prok +synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.3.1] +synonym: "(S)-dihydroorotate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.11] +synonym: "(S)-dihydroorotate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.11] +synonym: "DHOdehase activity" EXACT [EC:1.3.3.1] +synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.3.1] +synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.99.11] +xref: EC:1.3.99.11 +xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN +xref: Reactome:8412 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0004153 +name: dihydropterin deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydropterin + H20 = 7,8-dihydrolumazine + NH3." [GOC:jl, ISSN:05829879] +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004154 +name: dihydropterin oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + H2O2." [GOC:mah, PMID:1745247, PMID:6815189] +xref: EC:1.5.3.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004155 +name: 6,7-dihydropteridine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] +comment: Note that this function was formerly EC:1.6.99.7. +subset: gosubset_prok +synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] +synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] +synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] +synonym: "DHPR activity" EXACT [EC:1.5.1.34] +synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] +synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] +synonym: "dihydropteridine reductase activity" EXACT [] +synonym: "dihydropteridine reduction" RELATED [] +synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] +synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] +synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] +synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] +synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] +xref: EC:1.5.1.34 +xref: MetaCyc:1.5.1.34-RXN +xref: Reactome:8421 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004156 +name: dihydropteroate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] +subset: gosubset_prok +synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] +synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] +synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] +synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] +synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] +synonym: "DHPS activity" EXACT [EC:2.5.1.15] +synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] +synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] +synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] +synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] +xref: EC:2.5.1.15 +xref: MetaCyc:H2PTEROATESYNTH-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004157 +name: dihydropyrimidinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] +subset: gosubset_prok +synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] +synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] +synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] +synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] +synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] +synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] +xref: EC:3.5.2.2 +xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN +xref: Reactome:8430 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0004158 +name: dihydroorotate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2." [EC:1.3.3.1] +subset: gosubset_prok +synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] +synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] +xref: EC:1.3.3.1 +xref: MetaCyc:DIHYDROOROTOX-RXN +is_a: GO:0004152 ! dihydroorotate dehydrogenase activity +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0004159 +name: dihydrouracil dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] +synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] +synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] +synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] +synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] +synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] +xref: EC:1.3.1.1 +xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-(NAD+)-RXN +xref: Reactome:8435 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004160 +name: dihydroxy-acid dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] +subset: gosubset_prok +synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] +synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] +synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] +synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] +synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] +synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] +synonym: "DHAD" RELATED [EC:4.2.1.9] +synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] +xref: EC:4.2.1.9 +xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004161 +name: dimethylallyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] +comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. +subset: gosubset_prok +synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] +synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] +synonym: "dimethylallyltransferase activity" EXACT [] +synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] +synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] +synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] +synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] +synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] +synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] +xref: EC:2.5.1.1 +xref: MetaCyc:GPPSYN-RXN +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0004162 +name: dimethylnitrosamine demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] +synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0004163 +name: diphosphomevalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2." [EC:4.1.1.33] +subset: gosubset_prok +synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] +synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] +synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] +synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] +synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] +synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] +synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] +synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] +synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] +xref: EC:4.1.1.33 +xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN +xref: Reactome:8449 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004164 +name: diphthine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] +subset: gosubset_prok +synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] +synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] +synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] +xref: EC:2.1.1.98 +xref: MetaCyc:DIPHTHINE-SYNTHASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004165 +name: dodecenoyl-CoA delta-isomerase activity +namespace: molecular_function +alt_id: GO:0008461 +def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] +subset: gosubset_prok +synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] +synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] +synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] +synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] +synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] +synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] +synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] +synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] +synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] +synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] +synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] +xref: EC:5.3.3.8 +xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN +xref: Reactome:8459 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004166 +name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +alt_id: GO:0004101 +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] +synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] +synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] +synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] +synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] +synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] +synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] +synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] +xref: EC:2.4.1.153 +xref: MetaCyc:2.4.1.153-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0004167 +name: dopachrome isomerase activity +namespace: molecular_function +alt_id: GO:0048059 +def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12] +synonym: "DCF activity" EXACT [EC:5.3.3.12] +synonym: "DCT activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome conversion activity" BROAD [] +synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] +synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome delta-isomerase activity" EXACT [] +synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] +synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] +synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] +synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] +synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] +synonym: "TRP activity" EXACT [EC:5.3.3.12] +synonym: "TRP-1" RELATED [EC:5.3.3.12] +synonym: "TRP-2" RELATED [EC:5.3.3.12] +synonym: "TRP2" RELATED [EC:5.3.3.12] +synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] +synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] +xref: EC:5.3.3.12 +xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004168 +name: dolichol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] +synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] +synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] +xref: EC:2.7.1.108 +xref: MetaCyc:DOLICHOL-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004169 +name: dolichyl-phosphate-mannose-protein mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109] +subset: gosubset_prok +synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] +synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] +synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] +synonym: "O-glycoside mannosyltransferase" BROAD [] +synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] +synonym: "protein O-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.109 +xref: MetaCyc:2.4.1.109-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004170 +name: dUTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] +subset: gosubset_prok +synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] +synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] +synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] +synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] +synonym: "dUTP pyrophosphatase activity" EXACT [] +synonym: "dUTPase activity" EXACT [EC:3.6.1.23] +xref: EC:3.6.1.23 +xref: MetaCyc:DUTP-PYROP-RXN +xref: Reactome:8479 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0004171 +name: deoxyhypusine synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] +comment: This term was made obsolete because it represents a multistep reaction. +synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] +is_obsolete: true +replaced_by: GO:0008612 +replaced_by: GO:0034038 +replaced_by: GO:0050983 + +[Term] +id: GO:0004172 +name: ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents two molecular functions. +is_obsolete: true +consider: GO:0050488 +consider: GO:0050489 + +[Term] +id: GO:0004173 +name: ecdysone O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate." [EC:2.3.1.139] +synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] +synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] +synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] +xref: EC:2.3.1.139 +xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004174 +name: electron-transferring-flavoprotein dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] +subset: gosubset_prok +synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] +synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] +synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] +synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] +synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] +synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] +synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] +synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] +synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] +xref: EC:1.5.5.1 +xref: MetaCyc:1.5.5.1-RXN +xref: Reactome:8494 +is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0004175 +name: endopeptidase activity +namespace: molecular_function +alt_id: GO:0016809 +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] +subset: gosubset_prok +synonym: "endoprotease activity" EXACT [] +synonym: "proteasome endopeptidase activity" NARROW [] +synonym: "proteasome endopeptidase regulator" RELATED [] +synonym: "proteinase" BROAD [] +xref: Reactome:1793 +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0004176 +name: ATP-dependent peptidase activity +namespace: molecular_function +alt_id: GO:0004280 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds." [GOC:mah] +subset: gosubset_prok +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0004177 +name: aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.4.11 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0004178 +name: leucyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] +synonym: "cathepsin III" RELATED [EC:3.4.11.1] +synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] +synonym: "FTBL proteins" RELATED [EC:3.4.11.1] +synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] +synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] +synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] +synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] +synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] +synonym: "peptidase S activity" NARROW [EC:3.4.11.1] +synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] +xref: EC:3.4.11.1 +xref: MetaCyc:3.4.11.1-RXN +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0004179 +name: membrane alanyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] +synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] +synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] +synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] +synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] +synonym: "CD13" RELATED [EC:3.4.11.2] +synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] +synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] +synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] +synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] +synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] +synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] +synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] +synonym: "peptidase E activity" BROAD [EC:3.4.11.2] +synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] +xref: EC:3.4.11.2 +xref: MetaCyc:3.4.11.2-RXN +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0004180 +name: carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0004181 +name: metallocarboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.4.17 +is_a: GO:0004180 ! carboxypeptidase activity +is_a: GO:0008235 ! metalloexopeptidase activity + +[Term] +id: GO:0004182 +name: carboxypeptidase A activity +namespace: molecular_function +alt_id: GO:0008731 +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] +synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] +synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] +xref: EC:3.4.17.1 +xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004183 +name: carboxypeptidase E activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase H activity" EXACT [] +synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] +synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] +synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] +synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] +synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] +synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] +synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] +xref: EC:3.4.17.10 +xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004184 +name: lysine carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] +synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] +synonym: "bradykinase activity" EXACT [EC:3.4.17.3] +synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] +synonym: "carboxypeptidase N activity" EXACT [] +synonym: "CPase N" RELATED [EC:3.4.17.3] +synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] +synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] +synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] +synonym: "kininase I activity" EXACT [EC:3.4.17.3] +synonym: "kininase Ia" RELATED [EC:3.4.17.3] +synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] +synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] +synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] +synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] +xref: EC:3.4.17.3 +xref: MetaCyc:LYSINE(ARGININE)-CARBOXYPEPTIDASE-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004185 +name: serine-type carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] +subset: gosubset_prok +synonym: "serine carboxypeptidase activity" EXACT [] +xref: EC:3.4.16 +xref: Reactome:8533 +is_a: GO:0004180 ! carboxypeptidase activity +is_a: GO:0070008 ! serine-type exopeptidase activity + +[Term] +id: GO:0004186 +name: carboxypeptidase C activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5] +synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] +synonym: "deamidase" RELATED [EC:3.4.16.5] +synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] +synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] +synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] +synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] +synonym: "vacuolar carboxypeptidase Y" NARROW [] +xref: EC:3.4.16.5 +xref: MetaCyc:3.4.16.5-RXN +is_obsolete: true +replaced_by: GO:0004185 + +[Term] +id: GO:0004187 +name: carboxypeptidase D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] +synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] +synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6] +synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] +synonym: "CPDW-II" RELATED [EC:3.4.16.6] +synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] +synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] +synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] +synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] +synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] +xref: EC:3.4.16.6 +xref: MetaCyc:3.4.16.6-RXN +is_obsolete: true +replaced_by: GO:0004185 + +[Term] +id: GO:0004188 +name: serine-type Pro-X carboxypeptidase activity +namespace: molecular_function +alt_id: GO:0008323 +def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2] +synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] +synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] +synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] +synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2] +synonym: "PCP" RELATED [EC:3.4.16.2] +synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2] +synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] +synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] +synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] +xref: EC:3.4.16.2 +xref: MetaCyc:3.4.16.2-RXN +is_obsolete: true +replaced_by: GO:0004185 + +[Term] +id: GO:0004189 +name: tubulinyl-Tyr carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] +comment: This term was made obsolete because it represents a gene product. +synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17] +synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17] +synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "TTCPase activity" EXACT [EC:3.4.17.17] +synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] +synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] +synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] +synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] +synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] +synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] +xref: EC:3.4.17.17 +xref: MetaCyc:3.4.17.17-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004190 +name: aspartic-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aspartic endopeptidase activity" EXACT [] +synonym: "aspartic protease activity" EXACT [] +synonym: "aspartyl protease activity" EXACT [] +synonym: "carboxyl protease activity" EXACT [] +xref: EC:3.4.23 +xref: Reactome:1933 +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0070001 ! aspartic-type peptidase activity + +[Term] +id: GO:0004191 +name: barrierpepsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] +comment: This term was made obsolete because it represents a gene product. +synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] +synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] +synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] +xref: EC:3.4.23.35 +xref: MetaCyc:3.4.23.35-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004192 +name: cathepsin D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.23.5 +xref: MetaCyc:3.4.23.5-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004193 +name: cathepsin E activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34] +synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34] +synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34] +synonym: "EMAP" RELATED [EC:3.4.23.34] +synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] +synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] +synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] +synonym: "SMP" RELATED [EC:3.4.23.34] +xref: EC:3.4.23.34 +xref: MetaCyc:3.4.23.34-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004194 +name: pepsin A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] +synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] +synonym: "lactated pepsin" RELATED [EC:3.4.23.1] +synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] +synonym: "P I" RELATED [EC:3.4.23.1] +synonym: "P II" RELATED [EC:3.4.23.1] +synonym: "pepsin activity" BROAD [EC:3.4.23.1] +synonym: "pepsin D" RELATED [EC:3.4.23.1] +synonym: "pepsin fortior" RELATED [EC:3.4.23.1] +synonym: "pepsin R" RELATED [EC:3.4.23.1] +xref: EC:3.4.23.1 +xref: MetaCyc:3.4.23.1-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004195 +name: renin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] +comment: This term was made obsolete because it represents a gene product. +synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] +synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] +xref: EC:3.4.23.15 +xref: MetaCyc:3.4.23.15-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004196 +name: saccharopepsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] +comment: This term was made obsolete because it represents a gene product. +synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] +synonym: "PRA" RELATED [EC:3.4.23.25] +synonym: "proteinase A" RELATED [EC:3.4.23.25] +synonym: "proteinase yscA" RELATED [EC:3.4.23.25] +synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25] +synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] +synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] +synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] +synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] +xref: EC:3.4.23.25 +xref: MetaCyc:3.4.23.25-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004197 +name: cysteine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] +subset: gosubset_prok +synonym: "lysosomal cysteine-type endopeptidase" NARROW [] +synonym: "thiol endopeptidase activity" EXACT [] +xref: EC:3.4.22 +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0008234 ! cysteine-type peptidase activity + +[Term] +id: GO:0004198 +name: calcium-dependent cysteine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] +subset: gosubset_prok +synonym: "calpain activity" NARROW [] +is_a: GO:0004197 ! cysteine-type endopeptidase activity + +[Term] +id: GO:0004200 +name: signaling (initiator) caspase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes biological process information. +synonym: "signalling (initiator) caspase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 +consider: GO:0006915 + +[Term] +id: GO:0004201 +name: caspase-1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36] +comment: This term was made obsolete because it represents a gene product. +synonym: "ICE" BROAD [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004202 +name: caspase-2 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004203 +name: caspase-4 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004204 +name: caspase-5 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004205 +name: caspase-8 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004206 +name: caspase-10 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004207 +name: effector caspase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes biological process information. +is_obsolete: true +replaced_by: GO:0004197 +consider: GO:0006915 + +[Term] +id: GO:0004208 +name: caspase-3 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004209 +name: caspase-6 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004210 +name: caspase-7 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004211 +name: caspase-9 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004212 +name: lysosomal cysteine-type endopeptidase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0004197 +consider: GO:0005764 + +[Term] +id: GO:0004213 +name: cathepsin B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] +synonym: "cathepsin II" RELATED [EC:3.4.22.1] +xref: EC:3.4.22.1 +xref: MetaCyc:3.4.22.1-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004214 +name: dipeptidyl-peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin C activity" EXACT [EC:3.4.14.1] +synonym: "cathepsin J activity" EXACT [EC:3.4.14.1] +synonym: "DAP I" RELATED [EC:3.4.14.1] +synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] +synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1] +synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1] +xref: EC:3.4.14.1 +xref: MetaCyc:3.4.14.1-RXN +is_obsolete: true +replaced_by: GO:0008234 +replaced_by: GO:0008239 + +[Term] +id: GO:0004215 +name: cathepsin H activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] +comment: This term was made obsolete because it represents a gene product. +synonym: "aleurain activity" EXACT [EC:3.4.22.16] +synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16] +synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16] +synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] +synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] +synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] +xref: EC:3.4.22.16 +xref: MetaCyc:3.4.22.16-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004216 +name: cathepsin K activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] +synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] +synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] +xref: EC:3.4.22.38 +xref: MetaCyc:3.4.22.38-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004217 +name: cathepsin L activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] +comment: This term was made obsolete because it represents a gene product. +synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] +xref: EC:3.4.22.15 +xref: MetaCyc:3.4.22.15-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004218 +name: cathepsin S activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.22.27 +xref: MetaCyc:3.4.22.27-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004219 +name: pyroglutamyl-peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3] +synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3] +synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyrase activity" EXACT [EC:3.4.19.3] +synonym: "PYRase activity" EXACT [EC:3.4.19.3] +synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3] +synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3] +synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3] +xref: EC:3.4.19.3 +xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN +is_obsolete: true +replaced_by: GO:0008234 +replaced_by: GO:0016920 + +[Term] +id: GO:0004221 +name: ubiquitin thiolesterase activity +namespace: molecular_function +alt_id: GO:0008577 +def: "Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15] +comment: Note that this term is distinguished from its parent in that it specifically refers to hydrolysis of thiolester bonds. +subset: gosubset_prok +synonym: "ubiquitin C-terminal hydrolase activity" RELATED [] +synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15] +synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15] +synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15] +synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15] +synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] +xref: EC:3.1.2.15 +xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0004222 +name: metalloendopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] +subset: gosubset_prok +synonym: "metalloendoprotease activity" EXACT [GOC:mah] +synonym: "metalloendoproteinase activity" EXACT [GOC:mah] +xref: EC:3.4.24 +xref: Reactome:1791 +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0008237 ! metallopeptidase activity + +[Term] +id: GO:0004226 +name: Gly-X carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] +synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4] +synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] +synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] +synonym: "peptidase alpha" RELATED [EC:3.4.17.4] +synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] +xref: EC:3.4.17.4 +xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004228 +name: gelatinase A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24] +comment: This term was made obsolete because it represents a gene product. +synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24] +synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24] +synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24] +synonym: "collagenase IV" RELATED [EC:3.4.24.24] +synonym: "collagenase type IV" RELATED [EC:3.4.24.24] +synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24] +synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24] +synonym: "MMP 2" RELATED [EC:3.4.24.24] +synonym: "MMP-2" EXACT [] +synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] +synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] +synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] +xref: EC:3.4.24.24 +xref: MetaCyc:3.4.24.24-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004229 +name: gelatinase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35] +comment: This term was made obsolete because it represents a gene product. +synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35] +synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35] +synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35] +synonym: "collagenase IV" RELATED [EC:3.4.24.35] +synonym: "collagenase type IV" RELATED [EC:3.4.24.35] +synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35] +synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35] +synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35] +synonym: "MMP 9" RELATED [EC:3.4.24.35] +synonym: "MMP-9" EXACT [] +synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] +synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] +xref: EC:3.4.24.35 +xref: MetaCyc:3.4.24.35-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004230 +name: glutamyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] +synonym: "angiotensinase A" RELATED [EC:3.4.11.7] +synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] +synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] +synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] +synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7] +synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7] +synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] +synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] +xref: EC:3.4.11.7 +xref: MetaCyc:3.4.11.7-RXN +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0004231 +name: insulysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "IDE" RELATED [EC:3.4.24.56] +synonym: "insulin protease activity" EXACT [EC:3.4.24.56] +synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56] +synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56] +synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56] +synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56] +synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] +synonym: "insulinase activity" EXACT [EC:3.4.24.56] +synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] +xref: EC:3.4.24.56 +xref: MetaCyc:3.4.24.56-RXN +xref: Reactome:9609 +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004232 +name: interstitial collagenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 1" EXACT [] +synonym: "MMP-1" EXACT [] +synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] +xref: EC:3.4.24.7 +xref: MetaCyc:3.4.24.7-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004234 +name: macrophage elastase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] +comment: This term was made obsolete because it represents a gene product. +synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65] +synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65] +synonym: "metalloelastase activity" EXACT [EC:3.4.24.65] +synonym: "metalloesterase activity" EXACT [] +synonym: "MMP-12" EXACT [] +xref: EC:3.4.24.65 +xref: MetaCyc:3.4.24.65-RXN +is_obsolete: true +replaced_by: GO:0004175 +replaced_by: GO:0004222 + +[Term] +id: GO:0004235 +name: matrilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrin activity" EXACT [EC:3.4.24.23] +synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23] +synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23] +synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23] +synonym: "MMP" RELATED [EC:3.4.24.23] +synonym: "MMP 7" RELATED [EC:3.4.24.23] +synonym: "MMP-7" EXACT [] +synonym: "PUMP" RELATED [EC:3.4.24.23] +synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23] +synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] +synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] +synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] +synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] +xref: EC:3.4.24.23 +xref: MetaCyc:3.4.24.23-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004237 +name: membrane dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19] +synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] +synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19] +synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] +synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19] +synonym: "DPH I activity" NARROW [EC:3.4.13.19] +synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19] +synonym: "MDP" RELATED [EC:3.4.13.19] +synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] +synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19] +synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] +xref: EC:3.4.13.19 +xref: MetaCyc:3.4.13.19-RXN +is_obsolete: true +replaced_by: GO:0008235 +replaced_by: GO:0016805 + +[Term] +id: GO:0004238 +name: meprin A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] +comment: This term was made obsolete because it represents a gene product. +synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18] +synonym: "meprin" RELATED [EC:3.4.24.18] +synonym: "meprin-a" RELATED [EC:3.4.24.18] +synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] +synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] +synonym: "PPH" RELATED [EC:3.4.24.18] +xref: EC:3.4.24.18 +xref: MetaCyc:3.4.24.18-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004239 +name: methionyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18] +synonym: "MAP" RELATED [EC:3.4.11.18] +synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18] +synonym: "peptidase M activity" EXACT [EC:3.4.11.18] +xref: EC:3.4.11.18 +xref: MetaCyc:3.4.11.18-RXN +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0004240 +name: mitochondrial processing peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-mitochondrial processing peptidase" NARROW [] +synonym: "beta-mitochondrial processing peptidase" NARROW [] +synonym: "matrix peptidase" RELATED [EC:3.4.24.64] +synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64] +synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64] +synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64] +synonym: "MPP" EXACT [] +synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] +synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] +xref: EC:3.4.24.64 +xref: MetaCyc:3.4.24.64-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004241 +name: alpha-mitochondrial processing peptidase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-MPP" EXACT [] +is_obsolete: true +consider: GO:0004222 +consider: GO:0005739 + +[Term] +id: GO:0004242 +name: beta-mitochondrial processing peptidase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "beta-MPP" EXACT [] +is_obsolete: true +consider: GO:0004222 +consider: GO:0005739 + +[Term] +id: GO:0004243 +name: mitochondrial intermediate peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59] +comment: This term was made obsolete because it represents a gene product. +synonym: "MIP" BROAD [] +synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] +xref: EC:3.4.24.59 +xref: MetaCyc:3.4.24.59-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004244 +name: mitochondrial inner membrane peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] +comment: This term was made obsolete because it represents a gene product. +synonym: "IMP" BROAD [] +xref: EC:3.4.99.- +is_obsolete: true +replaced_by: GO:0004175 + +[Term] +id: GO:0004245 +name: neprilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] +synonym: "CALLA" RELATED [EC:3.4.24.11] +synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11] +synonym: "CALLA antigen" RELATED [EC:3.4.24.11] +synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11] +synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11] +synonym: "CD10" RELATED [EC:3.4.24.11] +synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] +synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11] +synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11] +synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11] +synonym: "enkephalinase activity" EXACT [EC:3.4.24.11] +synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11] +synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11] +synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11] +synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11] +synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] +synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] +synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] +xref: EC:3.4.24.11 +xref: MetaCyc:3.4.24.11-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004246 +name: peptidyl-dipeptidase A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "ACE activity" BROAD [] +synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] +synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1] +synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1] +synonym: "DCP" RELATED [EC:3.4.15.1] +synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] +synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1] +synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1] +synonym: "kininase II activity" EXACT [EC:3.4.15.1] +synonym: "PDH" RELATED [EC:3.4.15.1] +synonym: "peptidase P activity" EXACT [EC:3.4.15.1] +synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] +synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1] +synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] +synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1] +synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1] +synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1] +xref: EC:3.4.15.1 +xref: MetaCyc:3.4.15.1-RXN +is_obsolete: true +replaced_by: GO:0008237 +replaced_by: GO:0008241 + +[Term] +id: GO:0004247 +name: saccharolysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37] +comment: This term was made obsolete because it represents a gene product. +synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37] +synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] +synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] +synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] +xref: EC:3.4.24.37 +xref: MetaCyc:3.4.24.37-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004248 +name: stromelysin 1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17] +comment: This term was made obsolete because it represents a gene product. +synonym: "collagen-activating protein" RELATED [EC:3.4.24.17] +synonym: "collagenase activating protein" RELATED [EC:3.4.24.17] +synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17] +synonym: "MMP-3" EXACT [] +synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17] +synonym: "procollagenase activator" RELATED [EC:3.4.24.17] +synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] +synonym: "stromelysin" RELATED [EC:3.4.24.17] +synonym: "transin activity" EXACT [EC:3.4.24.17] +xref: EC:3.4.24.17 +xref: MetaCyc:3.4.24.17-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004249 +name: stromelysin 3 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 11" EXACT [] +synonym: "MMP-11" EXACT [] +xref: EC:3.4.24.- +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004250 +name: aminopeptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22] +synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] +synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22] +synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] +synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] +xref: EC:3.4.11.22 +xref: MetaCyc:3.4.11.22-RXN +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0004251 +name: X-Pro dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9] +synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9] +synonym: "peptidase D" RELATED [EC:3.4.13.9] +synonym: "prolidase activity" EXACT [EC:3.4.13.9] +synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9] +synonym: "Xaa-Pro dipeptidase activity" EXACT [] +xref: EC:3.4.13.9 +xref: MetaCyc:3.4.13.9-RXN +is_obsolete: true +replaced_by: GO:0008235 +replaced_by: GO:0016805 + +[Term] +id: GO:0004252 +name: serine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] +subset: gosubset_prok +synonym: "blood coagulation factor activity" RELATED [] +xref: EC:3.4.21 +xref: Reactome:1683 +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0008236 ! serine-type peptidase activity + +[Term] +id: GO:0004253 +name: gamma-renin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.21.54 +xref: MetaCyc:3.4.21.54-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004254 +name: acylaminoacyl-peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1] +subset: gosubset_prok +synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1] +synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] +synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] +synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] +xref: EC:3.4.19.1 +xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004258 +name: vacuolar carboxypeptidase Y +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0004185 +consider: GO:0005773 + +[Term] +id: GO:0004261 +name: cathepsin G activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20] +comment: This term was made obsolete because it represents a gene product. +synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] +synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] +xref: EC:3.4.21.20 +xref: MetaCyc:3.4.21.20-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004262 +name: cerevisin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48] +comment: This term was made obsolete because it represents a gene product. +synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48] +synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48] +synonym: "peptidase beta" RELATED [EC:3.4.21.48] +synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] +synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] +xref: EC:3.4.21.48 +xref: MetaCyc:3.4.21.48-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004263 +name: chymotrypsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "alpha-chymar" RELATED [EC:3.4.21.1] +synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] +synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1] +synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1] +synonym: "avazyme" RELATED [EC:3.4.21.1] +synonym: "chymar" RELATED [EC:3.4.21.1] +synonym: "chymotest" RELATED [EC:3.4.21.1] +synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1] +synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1] +synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] +synonym: "enzeon" RELATED [EC:3.4.21.1] +synonym: "quimar" RELATED [EC:3.4.21.1] +synonym: "quimotrase activity" EXACT [EC:3.4.21.1] +xref: EC:3.4.21.1 +xref: MetaCyc:3.4.21.1-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004274 +name: dipeptidyl-peptidase IV activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5] +synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] +synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] +synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] +synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5] +synonym: "DPP IV activity" EXACT [EC:3.4.14.5] +synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] +synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5] +synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] +synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5] +synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5] +synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] +synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] +synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] +synonym: "pep X" RELATED [EC:3.4.14.5] +synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] +synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] +synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] +synonym: "X-PDAP" RELATED [EC:3.4.14.5] +synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5] +synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] +xref: EC:3.4.14.5 +xref: MetaCyc:3.4.14.5-RXN +is_obsolete: true +replaced_by: GO:0008236 +replaced_by: GO:0008239 + +[Term] +id: GO:0004275 +name: enteropeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "enterokinase activity" RELATED [EC:3.4.21.9] +xref: EC:3.4.21.9 +xref: MetaCyc:3.4.21.9-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004276 +name: furin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75] +comment: This term was made obsolete because it represents a gene product. +synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75] +synonym: "PACE" RELATED [EC:3.4.21.75] +synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75] +synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75] +synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75] +synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] +synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] +synonym: "SPC3" RELATED [EC:3.4.21.75] +xref: EC:3.4.21.75 +xref: MetaCyc:3.4.21.75-RXN +xref: Reactome:9708 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004277 +name: granzyme A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78] +comment: This term was made obsolete because it represents a gene product. +synonym: "CTLA3" RELATED [EC:3.4.21.78] +synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78] +synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78] +synonym: "HuTPS" RELATED [EC:3.4.21.78] +synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] +synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] +synonym: "TSP-1" RELATED [EC:3.4.21.78] +xref: EC:3.4.21.78 +xref: MetaCyc:3.4.21.78-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004278 +name: granzyme B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79] +comment: This term was made obsolete because it represents a gene product. +synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79] +synonym: "CCPII" RELATED [EC:3.4.21.79] +synonym: "CTLA1" RELATED [EC:3.4.21.79] +synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79] +synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] +synonym: "granzyme G" RELATED [EC:3.4.21.79] +synonym: "granzyme H" RELATED [EC:3.4.21.79] +xref: EC:3.4.21.79 +xref: MetaCyc:3.4.21.79-RXN +xref: Reactome:9714 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004281 +name: pancreatic elastase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71] +comment: This term was made obsolete because it represents a gene product. +synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] +xref: EC:3.4.21.71 +xref: MetaCyc:3.4.21.71-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004283 +name: plasmin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7] +comment: This term was made obsolete because it represents a gene product. +synonym: "actase activity" EXACT [EC:3.4.21.7] +synonym: "fibrinase activity" EXACT [EC:3.4.21.7] +synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] +synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] +synonym: "thrombolysin" RELATED [EC:3.4.21.7] +xref: EC:3.4.21.7 +xref: MetaCyc:3.4.21.7-RXN +xref: Reactome:9727 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004284 +name: acrosin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10] +comment: This term was made obsolete because it represents a gene product. +synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10] +synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10] +synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10] +synonym: "acrozonase activity" EXACT [EC:3.4.21.10] +synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] +synonym: "beta-acrosin" RELATED [EC:3.4.21.10] +synonym: "psi-acrosin" RELATED [EC:3.4.21.10] +xref: EC:3.4.21.10 +xref: MetaCyc:3.4.21.10-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004285 +name: proprotein convertase 1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93] +comment: This term was made obsolete because it represents a gene product. +synonym: "NEC 1 activity" NARROW [EC:3.4.21.93] +synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93] +synonym: "PC1 activity" NARROW [EC:3.4.21.93] +synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] +synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] +xref: EC:3.4.21.93 +xref: MetaCyc:3.4.21.93-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004286 +name: proprotein convertase 2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94] +comment: This term was made obsolete because it represents a gene product. +synonym: "NEC 2 activity" NARROW [EC:3.4.21.94] +synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] +synonym: "PC2 activity" NARROW [EC:3.4.21.94] +synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] +xref: EC:3.4.21.94 +xref: MetaCyc:3.4.21.94-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004287 +name: prolyl oligopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26] +synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26] +synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26] +synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] +synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] +synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] +xref: EC:3.4.21.26 +xref: MetaCyc:3.4.21.26-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004289 +name: subtilase activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +xref: EC:3.4.21.- +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004290 +name: kexin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61] +comment: This term was made obsolete because it represents a gene product. +synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61] +synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61] +synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61] +synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61] +synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61] +synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61] +synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61] +synonym: "Kex2 protease" NARROW [EC:3.4.21.61] +synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61] +synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61] +synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61] +synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61] +synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61] +synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61] +synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61] +synonym: "protease KEX2" RELATED [EC:3.4.21.61] +synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] +synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] +synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] +synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] +xref: EC:3.4.21.61 +xref: MetaCyc:3.4.21.61-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004291 +name: subtilisin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62] +synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62] +synonym: "alcalase activity" EXACT [EC:3.4.21.62] +synonym: "ALK-enzyme" RELATED [EC:3.4.21.62] +synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62] +synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62] +synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62] +synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62] +synonym: "bioprase AL 15" RELATED [EC:3.4.21.62] +synonym: "bioprase APL 30" RELATED [EC:3.4.21.62] +synonym: "colistinase activity" EXACT [EC:3.4.21.62] +synonym: "esperase activity" EXACT [EC:3.4.21.62] +synonym: "genenase I" RELATED [EC:3.4.21.62] +synonym: "kazusase activity" EXACT [EC:3.4.21.62] +synonym: "maxatase activity" EXACT [EC:3.4.21.62] +synonym: "opticlean" RELATED [EC:3.4.21.62] +synonym: "orientase 10B" RELATED [EC:3.4.21.62] +synonym: "protease S" RELATED [EC:3.4.21.62] +synonym: "protease VIII" RELATED [EC:3.4.21.62] +synonym: "protease XXVII" RELATED [EC:3.4.21.62] +synonym: "protin A 3L" RELATED [EC:3.4.21.62] +synonym: "savinase 16.0L" RELATED [EC:3.4.21.62] +synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62] +synonym: "savinase 4.0T" RELATED [EC:3.4.21.62] +synonym: "savinase 8.0L" RELATED [EC:3.4.21.62] +synonym: "savinase activity" EXACT [EC:3.4.21.62] +synonym: "SP 266" RELATED [EC:3.4.21.62] +synonym: "subtilisin BL" RELATED [EC:3.4.21.62] +synonym: "subtilisin DY" RELATED [EC:3.4.21.62] +synonym: "subtilisin E" RELATED [EC:3.4.21.62] +synonym: "subtilisin GX" RELATED [EC:3.4.21.62] +synonym: "subtilisin J" RELATED [EC:3.4.21.62] +synonym: "subtilisin S41" RELATED [EC:3.4.21.62] +synonym: "subtilisin sendai" RELATED [EC:3.4.21.62] +synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] +synonym: "superase activity" EXACT [EC:3.4.21.62] +synonym: "thermoase" BROAD [EC:3.4.21.62] +synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] +xref: EC:3.4.21.62 +xref: MetaCyc:3.4.21.62-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004293 +name: tissue kallikrein activity +namespace: molecular_function +alt_id: GO:0004279 +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35] +comment: This term was made obsolete because it represents a gene product. +synonym: "bradykininogenase" BROAD [EC:3.4.21.35] +synonym: "callicrein" RELATED [EC:3.4.21.35] +synonym: "depot-padutin" RELATED [EC:3.4.21.35] +synonym: "dilminal D" RELATED [EC:3.4.21.35] +synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35] +synonym: "glumorin" RELATED [EC:3.4.21.35] +synonym: "kallidinogenase" BROAD [EC:3.4.21.35] +synonym: "kallikrein" RELATED [EC:3.4.21.35] +synonym: "kidney kallikrein" RELATED [EC:3.4.21.35] +synonym: "kininogenase" BROAD [EC:3.4.21.35] +synonym: "kininogenin activity" RELATED [EC:3.4.21.35] +synonym: "onokrein P" RELATED [EC:3.4.21.35] +synonym: "padreatin" RELATED [EC:3.4.21.35] +synonym: "padutin" RELATED [EC:3.4.21.35] +synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35] +synonym: "salivary kallikrein" RELATED [EC:3.4.21.35] +synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35] +synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] +synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] +synonym: "urokallikrein" RELATED [EC:3.4.21.35] +xref: EC:3.4.21.35 +xref: MetaCyc:3.4.21.35-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004294 +name: tripeptidyl-peptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] +comment: This term was made obsolete because it represents a gene product. +synonym: "TPP" RELATED [EC:3.4.14.10] +synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] +synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] +synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] +synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] +xref: EC:3.4.14.10 +xref: MetaCyc:3.4.14.10-RXN +is_obsolete: true +replaced_by: GO:0008240 + +[Term] +id: GO:0004295 +name: trypsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4] +synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4] +synonym: "cocoonase activity" EXACT [EC:3.4.21.4] +synonym: "parenzyme" RELATED [EC:3.4.21.4] +synonym: "parenzymol" RELATED [EC:3.4.21.4] +synonym: "pseudotrypsin" RELATED [EC:3.4.21.4] +synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4] +synonym: "tripcellim" RELATED [EC:3.4.21.4] +synonym: "tryptar" RELATED [EC:3.4.21.4] +synonym: "trypure" RELATED [EC:3.4.21.4] +xref: EC:3.4.21.4 +xref: MetaCyc:3.4.21.4-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004298 +name: threonine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] +subset: gosubset_prok +synonym: "26S protease" NARROW [EC:3.4.25] +synonym: "alkaline protease" RELATED [EC:3.4.25] +synonym: "ingensin" RELATED [EC:3.4.25] +synonym: "large multicatalytic protease" NARROW [EC:3.4.25] +synonym: "lens neutral proteinase" NARROW [EC:3.4.25] +synonym: "MCP" RELATED [EC:3.4.25] +synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25] +synonym: "multicatalytic proteinase" NARROW [EC:3.4.25] +synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25] +synonym: "prosome" RELATED [EC:3.4.25] +synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25] +synonym: "threonine endopeptidase activity" EXACT [] +synonym: "tricorn protease" NARROW [EC:3.4.25] +synonym: "tricorn proteinase" NARROW [EC:3.4.25] +xref: EC:3.4.25 +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0070003 ! threonine-type peptidase activity + +[Term] +id: GO:0004299 +name: proteasome endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1] +comment: This term was made obsolete because it mentions a component term in the text string. +synonym: "multicatalytic endopeptidase" RELATED [] +synonym: "proteasome" RELATED [] +synonym: "proteasome endopeptidase complex" RELATED [] +is_obsolete: true +consider: GO:0004175 +consider: GO:0008233 + +[Term] +id: GO:0004300 +name: enoyl-CoA hydratase activity +namespace: molecular_function +alt_id: GO:0016510 +def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O." [EC:4.2.1.17] +subset: gosubset_prok +synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17] +synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] +synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] +synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] +synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17] +synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17] +synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17] +synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] +synonym: "ECH" RELATED [EC:4.2.1.17] +synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17] +synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] +synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17] +synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] +synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17] +synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17] +synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] +synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] +synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] +synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] +xref: EC:4.2.1.17 +xref: MetaCyc:ENOYL-COA-HYDRAT-RXN +xref: Reactome:10287 +xref: UM-BBD_enzymeID:e0014 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004301 +name: epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] +subset: gosubset_prok +synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] +synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] +synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] +synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] +synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] +synonym: "sEH" RELATED [EC:3.3.2.10] +synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] +synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] +xref: EC:3.3.2.10 +xref: MetaCyc:3.3.2.10-RXN +xref: UM-BBD_enzymeID:e0397 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0004303 +name: estradiol 17-beta-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] +synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] +synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] +synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] +synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] +synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] +synonym: "17beta-HSD" RELATED [EC:1.1.1.62] +synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] +synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] +synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62] +synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] +synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62] +synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62] +xref: EC:1.1.1.62 +xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004304 +name: estrone sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] +synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] +synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] +synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4] +synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] +synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4] +synonym: "estrone sulphotransferase activity" EXACT [] +synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4] +xref: EC:2.8.2.4 +xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN +xref: Reactome:10293 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0004305 +name: ethanolamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ethanolamine = ADP + O-phosphoethanolamine." [EC:2.7.1.82] +synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82] +synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82] +synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82] +xref: EC:2.7.1.82 +xref: MetaCyc:ETHANOLAMINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004306 +name: ethanolamine-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] +synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] +synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] +synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] +synonym: "ET" RELATED [EC:2.7.7.14] +synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14] +synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] +synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] +xref: EC:2.7.7.14 +xref: MetaCyc:2.7.7.14-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004307 +name: ethanolaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] +synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] +synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1] +synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] +synonym: "EPT" RELATED [EC:2.7.8.1] +synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1] +xref: EC:2.7.8.1 +xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0004308 +name: exo-alpha-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] +subset: gosubset_prok +synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18] +synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18] +synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18] +synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18] +synonym: "neuraminidase activity" EXACT [EC:3.2.1.18] +synonym: "sialidase activity" EXACT [EC:3.2.1.18] +xref: EC:3.2.1.18 +xref: MetaCyc:3.2.1.18-RXN +is_a: GO:0016997 ! alpha-sialidase activity + +[Term] +id: GO:0004309 +name: exopolyphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] +subset: gosubset_prok +synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11] +synonym: "exopolypase activity" EXACT [EC:3.6.1.11] +synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11] +synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] +synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] +xref: EC:3.6.1.11 +xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004310 +name: farnesyl-diphosphate farnesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] +subset: gosubset_prok +synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21] +synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.21] +synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21] +synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21] +synonym: "squalene synthase activity" EXACT [EC:2.5.1.21] +synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21] +xref: EC:2.5.1.21 +xref: MetaCyc:2.5.1.21-RXN +xref: Reactome:10334 +is_a: GO:0004311 ! farnesyltranstransferase activity + +[Term] +id: GO:0004311 +name: farnesyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29] +subset: gosubset_prok +synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] +synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] +synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] +synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] +synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] +synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] +xref: EC:2.5.1.29 +xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN +xref: Reactome:10335 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0004312 +name: fatty-acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] +subset: gosubset_prok +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] +xref: EC:2.3.1.85 +xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0004313 +name: [acyl-carrier-protein] S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] +synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] +synonym: "ACAT activity" BROAD [EC:2.3.1.38] +synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38] +synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] +synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38] +synonym: "ACP S-acetyltransferase activity" EXACT [] +synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38] +synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38] +synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] +synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] +xref: EC:2.3.1.38 +xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN +xref: Reactome:76142 +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0004314 +name: [acyl-carrier-protein] S-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] +subset: gosubset_prok +synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] +synonym: "ACP S-malonyltransferase activity" EXACT [] +synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39] +synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39] +synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] +synonym: "FabD" RELATED [EC:2.3.1.39] +synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] +synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] +synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] +synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] +synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39] +synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39] +synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] +synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] +synonym: "MAT" RELATED [EC:2.3.1.39] +synonym: "MCAT activity" EXACT [EC:2.3.1.39] +xref: EC:2.3.1.39 +xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN +xref: Reactome:10341 +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0016419 ! S-malonyltransferase activity + +[Term] +id: GO:0004315 +name: 3-oxoacyl-[acyl-carrier-protein] synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] +subset: gosubset_prok +synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] +synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] +synonym: "3-oxoacyl-ACP synthase activity" EXACT [] +synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41] +synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41] +synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41] +synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41] +synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41] +synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] +synonym: "FabB" RELATED [EC:2.3.1.41] +synonym: "FabF1" RELATED [EC:2.3.1.41] +synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] +synonym: "KAS I activity" NARROW [EC:2.3.1.41] +synonym: "KASI" RELATED [EC:2.3.1.41] +synonym: "ketoacyl-ACP synthase activity" EXACT [] +xref: EC:2.3.1.41 +xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN +xref: Reactome:76136 +is_a: GO:0004312 ! fatty-acid synthase activity + +[Term] +id: GO:0004316 +name: 3-oxoacyl-[acyl-carrier-protein] reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] +subset: gosubset_prok +synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100] +synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] +synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] +synonym: "3-oxoacyl-ACP reductase activity" EXACT [] +synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100] +synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100] +synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100] +synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100] +synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100] +synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100] +synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] +synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100] +synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100] +xref: EC:1.1.1.100 +xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN +xref: Reactome:76148 +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004317 +name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61] +synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61] +synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61] +synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61] +synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] +synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] +synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61] +synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61] +synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61] +synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61] +synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] +xref: EC:4.2.1.61 +xref: MetaCyc:4.2.1.61-RXN +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0004318 +name: enoyl-[acyl-carrier-protein] reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] +subset: gosubset_prok +synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9] +synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9] +synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9] +synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9] +synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9] +synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9] +xref: EC:1.3.1.9 +xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity + +[Term] +id: GO:0004319 +name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] +subset: gosubset_prok +synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10] +synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10] +synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] +synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] +synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10] +synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10] +synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10] +synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10] +xref: EC:1.3.1.10 +xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN +xref: Reactome:76151 +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity + +[Term] +id: GO:0004320 +name: oleoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] +subset: gosubset_prok +synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "oleoyl-ACP hydrolase activity" EXACT [] +synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14] +synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14] +synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] +xref: EC:3.1.2.14 +xref: MetaCyc:3.1.2.14-RXN +xref: MetaCyc:PWY-5142 +xref: Reactome:76154 +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0004321 +name: fatty-acyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86] +synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] +xref: EC:2.3.1.86 +xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0004322 +name: ferroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] +subset: gosubset_prok +synonym: "caeruloplasmin" RELATED [EC:1.16.3.1] +synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1] +synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] +synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1] +synonym: "ferroxidase I" RELATED [EC:1.16.3.1] +synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] +synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] +synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] +xref: EC:1.16.3.1 +xref: MetaCyc:RXN0-1483 +is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor + +[Term] +id: GO:0004323 +name: multicopper ferroxidase iron transport mediator activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0004322 +consider: GO:0005381 + +[Term] +id: GO:0004324 +name: ferredoxin-NADP+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd] +comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. +subset: gosubset_prok +synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2] +synonym: "ferredoxin-NADP reductase activity" EXACT [] +synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2] +synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2] +synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2] +synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2] +synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2] +synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] +synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] +synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2] +synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] +xref: EC:1.18.1.2 +is_a: GO:0008937 ! ferredoxin reductase activity + +[Term] +id: GO:0004325 +name: ferrochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [EC:4.99.1.1] +subset: gosubset_prok +synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1] +synonym: "heme synthase activity" EXACT [EC:4.99.1.1] +synonym: "heme synthetase activity" EXACT [EC:4.99.1.1] +synonym: "iron chelatase activity" EXACT [EC:4.99.1.1] +synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1] +synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1] +synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1] +xref: EC:4.99.1.1 +xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN +xref: Reactome:10394 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0004326 +name: tetrahydrofolylpolyglutamate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] +subset: gosubset_prok +synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17] +synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17] +synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17] +synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17] +synonym: "folylpolyglutamate synthase activity" EXACT [] +synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17] +synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17] +synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] +synonym: "FPGS activity" EXACT [EC:6.3.2.17] +synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] +synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] +synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17] +synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17] +synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] +synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] +xref: EC:6.3.2.17 +xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004327 +name: formaldehyde dehydrogenase (glutathione) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] +comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries. +subset: gosubset_prok +xref: UM-BBD_enzymeID:e0028 +is_obsolete: true +consider: GO:0051903 +consider: GO:0051907 + +[Term] +id: GO:0004328 +name: formamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: formamide + H2O = formate + NH3." [EC:3.5.1.49] +subset: gosubset_prok +synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49] +xref: EC:3.5.1.49 +xref: MetaCyc:FORMAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004329 +name: formate-tetrahydrofolate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] +subset: gosubset_prok +synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] +synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3] +synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] +synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3] +synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3] +xref: EC:6.3.4.3 +xref: MetaCyc:FORMATETHFLIG-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004331 +name: fructose-2,6-bisphosphate 2-phosphatase activity +namespace: molecular_function +alt_id: GO:0004330 +def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.46] +subset: gosubset_prok +synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] +synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] +synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46] +xref: EC:3.1.3.46 +xref: MetaCyc:3.1.3.46-RXN +xref: Reactome:10434 +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0004332 +name: fructose-bisphosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.13] +subset: gosubset_prok +synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] +synonym: "aldolase activity" BROAD [EC:4.1.2.13] +synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13] +synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13] +synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] +synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13] +synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13] +synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13] +synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] +synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13] +synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13] +synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] +synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13] +synonym: "SMALDO" RELATED [EC:4.1.2.13] +synonym: "zymohexase activity" EXACT [EC:4.1.2.13] +xref: EC:4.1.2.13 +xref: MetaCyc:F16ALDOLASE-RXN +xref: Reactome:10435 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004333 +name: fumarate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2] +subset: gosubset_prok +synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2] +synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2] +synonym: "fumarase activity" EXACT [EC:4.2.1.2] +synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2] +xref: EC:4.2.1.2 +xref: MetaCyc:FUMHYDR-RXN +xref: Reactome:10436 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004334 +name: fumarylacetoacetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate." [EC:3.7.1.2] +subset: gosubset_prok +synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2] +synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2] +synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2] +xref: EC:3.7.1.2 +xref: MetaCyc:FUMARYLACETOACETASE-RXN +xref: Reactome:10438 +xref: UM-BBD_enzymeID:e0083 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0004335 +name: galactokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate." [EC:2.7.1.6] +subset: gosubset_prok +synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6] +synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6] +synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6] +xref: EC:2.7.1.6 +xref: MetaCyc:GALACTOKIN-RXN +xref: Reactome:10440 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004336 +name: galactosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] +synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46] +synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46] +synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46] +synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactocerebroside.beta-galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] +synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactosylceramide.beta-galactosidase activity" EXACT [EC:3.2.1.46] +synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46] +synonym: "galcerase activity" EXACT [EC:3.2.1.46] +synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46] +synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] +xref: EC:3.2.1.46 +xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0017040 ! ceramidase activity + +[Term] +id: GO:0004337 +name: geranyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate." [EC:2.5.1.10] +comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. +subset: gosubset_prok +synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10] +synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] +synonym: "farnesyl-diphosphate synthase activity" EXACT [] +synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10] +synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10] +synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] +synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10] +synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10] +xref: EC:2.5.1.10 +xref: MetaCyc:FPPSYN-RXN +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0004338 +name: glucan 1,3-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] +synonym: "1,3-beta-glucan glucohydrolase activity" EXACT [EC:3.2.1.58] +synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58] +synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58] +synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58] +synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58] +synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58] +synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58] +synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58] +synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58] +synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58] +xref: EC:3.2.1.58 +xref: MetaCyc:3.2.1.58-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0004339 +name: glucan 1,4-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] +comment: Note that this term is not a child of 'alpha-glucosides activity ; GO:0004558', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0004558 alpha-D-glucose is released. +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] +synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3] +synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3] +synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] +synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3] +synonym: "glucoamylase activity" EXACT [] +synonym: "glucose amylase activity" EXACT [EC:3.2.1.3] +synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] +xref: EC:3.2.1.3 +xref: MetaCyc:3.2.1.3-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004340 +name: glucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate." [EC:2.7.1.2] +subset: gosubset_prok +synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2] +synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2] +synonym: "glucose kinase activity" EXACT [EC:2.7.1.2] +xref: EC:2.7.1.2 +xref: MetaCyc:GLUCOKIN-RXN +xref: Reactome:10457 +is_a: GO:0004396 ! hexokinase activity + +[Term] +id: GO:0004341 +name: gluconolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] +subset: gosubset_prok +synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17] +synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17] +synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17] +synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17] +synonym: "lactonase activity" BROAD [EC:3.1.1.17] +xref: EC:3.1.1.17 +xref: MetaCyc:GLUCONOLACT-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0004342 +name: glucosamine-6-phosphate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3." [EC:3.5.99.6] +comment: Note that this function was formerly EC:5.3.1.10. +subset: gosubset_prok +synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6] +synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6] +synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6] +synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6] +synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6] +synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] +synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6] +synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6] +xref: EC:3.5.99.6 +xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004343 +name: glucosamine 6-phosphate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate." [EC:2.3.1.4] +subset: gosubset_prok +synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4] +synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4] +synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4] +synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4] +synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4] +synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] +synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4] +synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4] +synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4] +synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4] +xref: EC:2.3.1.4 +xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004344 +name: glucose dehydrogenase activity +namespace: molecular_function +alt_id: GO:0008708 +def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] +synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10] +synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2] +synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] +synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] +synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10] +xref: EC:1.1.-.- +xref: EC:1.1.99.10 +xref: MetaCyc:GLUCOSE-DEHYDROGENASE-(ACCEPTOR)-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0004345 +name: glucose-6-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] +subset: gosubset_prok +synonym: "6-phosphoglucose dehydrogenas" RELATED [] +synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] +synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] +synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49] +synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] +synonym: "G6PD activity" EXACT [EC:1.1.1.49] +synonym: "G6PDH" EXACT [] +synonym: "GDH" RELATED [] +synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] +synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] +synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] +synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] +synonym: "Zwischenferment" RELATED [] +synonym: "zwischenferment" RELATED [EC:1.1.1.49] +xref: EC:1.1.1.49 +xref: MetaCyc:GLU6PDEHYDROG-RXN +xref: Reactome:10468 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004346 +name: glucose-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.9] +subset: gosubset_prok +synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9] +synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9] +xref: EC:3.1.3.9 +xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN +xref: Reactome:10470 +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0004347 +name: glucose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] +subset: gosubset_prok +synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9] +synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9] +synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9] +synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] +synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9] +synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] +synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] +synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9] +synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9] +synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] +synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] +synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] +synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] +xref: EC:5.3.1.9 +xref: MetaCyc:PGLUCISOM-RXN +xref: Reactome:10472 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004348 +name: glucosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] +subset: gosubset_prok +synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45] +synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45] +synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45] +synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45] +synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45] +synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45] +synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45] +synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45] +synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45] +synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45] +synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45] +synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45] +synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45] +xref: EC:3.2.1.45 +xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0017040 ! ceramidase activity + +[Term] +id: GO:0004349 +name: glutamate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate." [EC:2.7.2.11] +subset: gosubset_prok +synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] +synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11] +synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] +synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11] +synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11] +synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11] +xref: EC:2.7.2.11 +xref: MetaCyc:GLUTKIN-RXN +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004350 +name: glutamate-5-semialdehyde dehydrogenase activity +namespace: molecular_function +alt_id: GO:0001513 +def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+." [EC:1.2.1.41] +subset: gosubset_prok +synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] +synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41] +synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] +synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] +synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] +synonym: "glutamate-phosphate reductase activity" EXACT [] +synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] +synonym: "glutamylphosphate reductase activity" EXACT [] +synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41] +xref: EC:1.2.1.41 +xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004351 +name: glutamate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] +subset: gosubset_prok +synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] +synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15] +synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15] +synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15] +synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15] +synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15] +synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15] +synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] +synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] +xref: EC:4.1.1.15 +xref: MetaCyc:GLUTDECARBOX-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004352 +name: glutamate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] +subset: gosubset_prok +synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] +synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] +synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] +synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] +synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] +synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] +synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] +synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] +synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] +xref: EC:1.4.1.2 +xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004353 +name: glutamate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +subset: gosubset_prok +synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] +synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] +synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] +synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3] +xref: EC:1.4.1.3 +xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-(NAD(P)+)-RXN +xref: MetaCyc:GLUTAMATE-SYN2-PWY +xref: Reactome:10485 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004354 +name: glutamate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] +subset: gosubset_prok +synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] +synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] +synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] +synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] +synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] +synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] +synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] +synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] +xref: EC:1.4.1.4 +xref: MetaCyc:GLUTDEHYD-RXN +xref: MetaCyc:GLUTSYNIII-PWY +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004355 +name: glutamate synthase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +subset: gosubset_prok +synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13] +synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13] +synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13] +synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13] +synonym: "GOGAT activity" EXACT [EC:1.4.1.13] +synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] +synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] +synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13] +synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13] +synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13] +synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13] +synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13] +xref: EC:1.4.1.13 +xref: MetaCyc:GLUGLNSYN-PWY +xref: MetaCyc:GLUTAMATESYN-RXN +xref: MetaCyc:GLUTSYN-PWY +is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor + +[Term] +id: GO:0004356 +name: glutamate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine." [EC:6.3.1.2] +subset: gosubset_prok +synonym: "glutamine synthetase activity" EXACT [] +synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] +synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] +synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] +xref: EC:6.3.1.2 +xref: MetaCyc:GLUTAMINESYN-RXN +xref: Reactome:10495 +is_a: GO:0016211 ! ammonia ligase activity + +[Term] +id: GO:0004357 +name: glutamate-cysteine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine." [EC:6.3.2.2] +subset: gosubset_prok +synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] +synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] +synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] +synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] +xref: EC:6.3.2.2 +xref: MetaCyc:GLUTCYSLIG-RXN +xref: Reactome:10497 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004358 +name: glutamate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate." [EC:2.3.1.35] +subset: gosubset_prok +synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] +synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35] +synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] +synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35] +synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] +synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] +synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] +synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] +synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] +synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] +synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] +synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] +synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] +synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35] +synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35] +xref: EC:2.3.1.35 +xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004359 +name: glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] +subset: gosubset_prok +synonym: "glutaminase I" RELATED [EC:3.5.1.2] +synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2] +synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2] +synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2] +xref: EC:3.5.1.2 +xref: MetaCyc:GLUTAMIN-RXN +xref: Reactome:10219 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004360 +name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate." [EC:2.6.1.16] +subset: gosubset_prok +synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] +synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16] +synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16] +synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16] +synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] +synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16] +synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] +synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16] +synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] +synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16] +xref: EC:2.6.1.16 +xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004361 +name: glutaryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7] +subset: gosubset_prok +synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7] +synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] +synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] +xref: EC:1.3.99.7 +xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN +xref: Reactome:10507 +xref: UM-BBD_enzymeID:e0123 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0004362 +name: glutathione-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this function was formerly EC:1.6.4.2. +subset: gosubset_prok +synonym: "glutathione reductase (NADPH) activity" EXACT [] +synonym: "glutathione reductase activity" EXACT [] +synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] +synonym: "glutathione-disulphide reductase activity" EXACT [] +synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] +synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] +synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] +synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] +synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] +synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] +synonym: "oxidized glutathione reduction" RELATED [] +xref: EC:1.8.1.7 +xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN +xref: Reactome:10508 +is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004363 +name: glutathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione." [EC:6.3.2.3] +subset: gosubset_prok +synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] +synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] +synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] +xref: EC:6.3.2.3 +xref: MetaCyc:GLUTATHIONE-SYN-RXN +xref: Reactome:10524 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004364 +name: glutathione transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] +subset: gosubset_prok +synonym: "glutathione conjugation reaction" EXACT [] +synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] +synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] +synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] +synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] +synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] +synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] +synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] +xref: EC:2.5.1.18 +xref: MetaCyc:GSHTRAN-RXN +xref: Reactome:10527 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004365 +name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] +subset: gosubset_prok +synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] +synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12] +synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12] +synonym: "GAPDH activity" EXACT [EC:1.2.1.12] +synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12] +synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12] +synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] +synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] +synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] +synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] +synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] +xref: EC:1.2.1.12 +xref: MetaCyc:GAPOXNPHOSPHN-RXN +xref: Reactome:10530 +is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity + +[Term] +id: GO:0004366 +name: glycerol-3-phosphate O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] +subset: gosubset_prok +synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15] +synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15] +synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] +synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] +xref: EC:2.3.1.15 +xref: MetaCyc:RXN-1381 +xref: Reactome:10531 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004367 +name: glycerol-3-phosphate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8] +subset: gosubset_prok +synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] +synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] +synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] +synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] +synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] +synonym: "hydroglycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "L-alpha-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "L-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "L-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] +synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] +xref: EC:1.1.1.8 +xref: MetaCyc:1.1.1.8-RXN +xref: Reactome:10533 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004368 +name: glycerol-3-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor." [EC:1.1.99.5] +subset: gosubset_prok +synonym: "alpha-glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5] +synonym: "alpha-glycerophosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5] +synonym: "dehydrogenase, glycerol phosphate (acceptor)" EXACT [EC:1.1.99.5] +synonym: "DL-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5] +synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "FAD-dependent sn-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "FAD-linked glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "FAD-linked L-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "flavoprotein-linked L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "glycerol 3-phosphate cytochrome c reductase" NARROW [EC:1.1.99.5] +synonym: "glycerol phosphate dehydrogenase" EXACT [EC:1.1.99.5] +synonym: "glycerol phosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5] +synonym: "glycerol phosphate dehydrogenase (FAD)" NARROW [EC:1.1.99.5] +synonym: "glycerol-3-phosphate dehydrogenase (flavin-linked)" NARROW [EC:1.1.99.5] +synonym: "glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5] +synonym: "L-3-glycerophosphate-ubiquinone oxidoreductase" EXACT [EC:1.1.99.5] +synonym: "L-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5] +synonym: "NAD-independent glycerol phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] +synonym: "sn-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5] +synonym: "sn-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5] +synonym: "sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.5] +synonym: "sn-glycerol-3-phosphate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.5] +xref: EC:1.1.99.5 +xref: MetaCyc:GLYCEROL-3-PHOSPHATE-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0004369 +name: glycerol-3-phosphate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2." [EC:1.1.3.21] +subset: gosubset_prok +synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] +synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21] +synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21] +synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21] +synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] +synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21] +xref: EC:1.1.3.21 +xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0004370 +name: glycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate." [EC:2.7.1.30] +subset: gosubset_prok +synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30] +synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30] +synonym: "GK" RELATED [EC:2.7.1.30] +synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30] +synonym: "glycerokinase activity" EXACT [EC:2.7.1.30] +synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30] +xref: EC:2.7.1.30 +xref: MetaCyc:GLYCEROL-KIN-RXN +xref: Reactome:10545 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004371 +name: glycerone kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate." [EC:2.7.1.29] +subset: gosubset_prok +synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29] +synonym: "acetol kinase activity" EXACT [EC:2.7.1.29] +synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29] +synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29] +xref: EC:2.7.1.29 +xref: MetaCyc:GLYCERONE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004372 +name: glycine hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] +subset: gosubset_prok +synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] +synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1] +synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] +synonym: "serine aldolase activity" EXACT [EC:2.1.2.1] +synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1] +synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] +synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1] +xref: EC:2.1.2.1 +xref: MetaCyc:GLYOHMETRANS-RXN +xref: Reactome:1060 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0004373 +name: glycogen (starch) synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] +subset: gosubset_prok +synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] +synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] +synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] +synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] +synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11] +synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11] +synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] +synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] +xref: EC:2.4.1.11 +xref: MetaCyc:GLYCOGEN-(STARCH)-SYNTHASE-RXN +xref: Reactome:10552 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0004374 +name: glycine cleavage system +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10] +comment: This term was made obsolete because it represents a process rather than a function. +synonym: "glycine synthase" BROAD [] +is_obsolete: true +replaced_by: GO:0019464 + +[Term] +id: GO:0004375 +name: glycine dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] +subset: gosubset_prok +synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] +synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2] +synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] +synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2] +synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2] +synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2] +synonym: "P-protein" NARROW [EC:1.4.4.2] +synonym: "protein P1" NARROW [EC:1.4.4.2] +xref: EC:1.4.4.2 +xref: MetaCyc:GCVP-RXN +is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor + +[Term] +id: GO:0004376 +name: glycolipid mannosyltransferase activity +namespace: molecular_function +alt_id: GO:0004580 +def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] +synonym: "glycolipid mannosyl transferase activity" EXACT [] +xref: EC:2.4.1.- +xref: Reactome:10559 +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004377 +name: glycolipid 2-alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] +synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] +synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131] +synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] +synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] +xref: EC:2.4.1.131 +xref: MetaCyc:2.4.1.131-RXN +is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity +is_a: GO:0004376 ! glycolipid mannosyltransferase activity + +[Term] +id: GO:0004378 +name: glycolipid 3-alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] +synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] +synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132] +synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132] +synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132] +xref: EC:2.4.1.132 +xref: MetaCyc:2.4.1.132-RXN +is_a: GO:0004376 ! glycolipid mannosyltransferase activity + +[Term] +id: GO:0004379 +name: glycylpeptide N-tetradecanoyltransferase activity +namespace: molecular_function +alt_id: GO:0019106 +def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] +synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] +synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97] +synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] +synonym: "N-myristoyltransferase activity" EXACT [] +synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97] +synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] +synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] +synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] +xref: EC:2.3.1.97 +xref: MetaCyc:2.3.1.97-RXN +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0019107 ! myristoyltransferase activity + +[Term] +id: GO:0004380 +name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] +synonym: "A transferase activity" RELATED [EC:2.4.1.40] +synonym: "A-transferase activity" EXACT [EC:2.4.1.40] +synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] +synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40] +synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] +synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] +synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] +xref: EC:2.4.1.40 +xref: MetaCyc:2.4.1.40-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0004381 +name: fucosylgalactoside 3-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] +synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "B transferase activity" RELATED [EC:2.4.1.37] +synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37] +synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] +synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] +synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37] +synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] +synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] +synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] +synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] +xref: EC:2.4.1.37 +xref: MetaCyc:2.4.1.37-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0004382 +name: guanosine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] +synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] +synonym: "GDPase activity" EXACT [EC:3.6.1.42] +synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] +synonym: "guanosine diphosphatase activity" EXACT [] +xref: EC:3.6.1.42 +xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0004383 +name: guanylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] +subset: gosubset_prok +synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2] +synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2] +synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2] +synonym: "guanylyl cyclase activity" EXACT [] +synonym: "receptor guanylate cyclase activity" NARROW [] +xref: EC:4.6.1.2 +xref: MetaCyc:GUANYLCYC-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0004384 +name: membrane-associated guanylate kinase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8] +comment: This term was made obsolete because it represents a gene product and not a function. +synonym: "MAGUK" EXACT [] +is_obsolete: true +consider: GO:0004385 +consider: GO:0005102 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0050839 + +[Term] +id: GO:0004385 +name: guanylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] +subset: gosubset_prok +synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8] +synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8] +synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8] +synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] +synonym: "GMP kinase activity" EXACT [EC:2.7.4.8] +synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8] +synonym: "membrane-associated guanylate kinase" NARROW [] +xref: EC:2.7.4.8 +xref: MetaCyc:GUANYL-KIN-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019201 ! nucleotide kinase activity + +[Term] +id: GO:0004386 +name: helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that most helicases catalyze processive duplex unwinding. +subset: goslim_candida +subset: goslim_goa +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +xref: Reactome:7001 +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0004392 +name: heme oxygenase (decyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3] +synonym: "haem oxidase activity" EXACT [EC:1.14.99.3] +synonym: "haem oxygenase (decyclizing) activity" EXACT [] +synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3] +synonym: "heme oxidase activity" EXACT [EC:1.14.99.3] +synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3] +synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3] +synonym: "ORP33 proteins" RELATED [EC:1.14.99.3] +xref: EC:1.14.99.3 +xref: MetaCyc:HEME-OXYGENASE-(DECYCLIZING)-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004394 +name: heparan sulfate 2-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] +synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] +synonym: "heparin 2-sulfotransferase activity" RELATED [] +synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] +xref: EC:2.8.2.- +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0004395 +name: hexaprenyldihydroxybenzoate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] +synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] +synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114] +synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114] +synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] +synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114] +xref: EC:2.1.1.114 +xref: MetaCyc:2.1.1.114-RXN +is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity + +[Term] +id: GO:0004396 +name: hexokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] +subset: gosubset_prok +synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1] +synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1] +synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1] +synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1] +synonym: "hexokinase D" RELATED [EC:2.7.1.1] +synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] +synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1] +xref: EC:2.7.1.1 +xref: MetaCyc:HEXOKINASE-RXN +xref: Reactome:10602 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004397 +name: histidine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] +subset: gosubset_prok +synonym: "histidase activity" RELATED [GOC:hjd] +synonym: "histidinase activity" RELATED [GOC:hjd] +synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] +synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3] +synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3] +xref: EC:4.3.1.3 +xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN +xref: Reactome:10604 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0004398 +name: histidine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] +subset: gosubset_prok +synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22] +synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22] +synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22] +xref: EC:4.1.1.22 +xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004399 +name: histidinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] +subset: gosubset_prok +xref: EC:1.1.1.23 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004400 +name: histidinol-phosphate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] +subset: gosubset_prok +synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] +synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] +synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] +synonym: "histidinol-phosphate aminotransferase activity" EXACT [] +synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9] +synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9] +synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] +synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9] +synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9] +synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] +synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9] +xref: EC:2.6.1.9 +xref: MetaCyc:HISTAMINOTRANS-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004401 +name: histidinol-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidinol-phosphate + H2O = L-histidinol + phosphate." [EC:3.1.3.15] +subset: gosubset_prok +synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] +synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15] +synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15] +synonym: "HPpase activity" EXACT [EC:3.1.3.15] +synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] +synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15] +xref: EC:3.1.3.15 +xref: MetaCyc:HISTIDPHOS-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004402 +name: histone acetyltransferase activity +namespace: molecular_function +alt_id: GO:0004403 +alt_id: GO:0004404 +alt_id: GO:0046971 +def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] +comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. +synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48] +synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48] +synonym: "histone acetylase activity" EXACT [] +synonym: "histone lysine acetyltransferase activity" EXACT [] +synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48] +synonym: "nucleosome-histone acetyltransferase activity" EXACT [EC:2.3.1.48] +xref: EC:2.3.1.48 +xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN +is_a: GO:0004468 ! lysine N-acetyltransferase activity + +[Term] +id: GO:0004405 +name: H2A/H2B histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H2A and H2B." [GOC:jl, PMID:9241414] +xref: EC:2.3.1.- +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0004406 +name: H3/H4 histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H3 and H4." [GOC:jl, PMID:9241414] +xref: EC:2.3.1.- +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0004407 +name: histone deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, http://cancerweb.ncl.ac.uk/] +xref: EC:3.5.1.- +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0033558 ! protein deacetylase activity + +[Term] +id: GO:0004408 +name: holocytochrome-c synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] +subset: gosubset_prok +synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17] +synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] +synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17] +synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17] +synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] +xref: EC:4.4.1.17 +xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004409 +name: homoaconitate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxybutane-1,2,4-tricarboxylate = but-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.36] +subset: gosubset_prok +synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] +synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36] +synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36] +synonym: "HACN activity" EXACT [EC:4.2.1.36] +synonym: "homoaconitase activity" EXACT [EC:4.2.1.36] +synonym: "Lys4" RELATED [EC:4.2.1.36] +synonym: "LysF" RELATED [EC:4.2.1.36] +xref: EC:4.2.1.36 +xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004410 +name: homocitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA." [EC:2.3.3.14] +comment: Note that this function was formerly EC:4.1.3.21. +subset: gosubset_prok +synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] +synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] +synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] +synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] +synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] +xref: EC:2.3.3.14 +xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004411 +name: homogentisate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate." [EC:1.13.11.5] +subset: gosubset_prok +synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5] +synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5] +synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5] +synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5] +synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5] +synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5] +synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5] +synonym: "homogentisicase activity" EXACT [EC:1.13.11.5] +xref: EC:1.13.11.5 +xref: MetaCyc:HOMOGENTISATE-1\,2-DIOXYGENASE-RXN +xref: Reactome:11355 +xref: UM-BBD_enzymeID:e0081 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004412 +name: homoserine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] +subset: gosubset_prok +xref: EC:1.1.1.3 +xref: MetaCyc:HOMOSERDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004413 +name: homoserine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine." [EC:2.7.1.39] +subset: gosubset_prok +synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39] +synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39] +synonym: "HSK" RELATED [EC:2.7.1.39] +xref: EC:2.7.1.39 +xref: MetaCyc:HOMOSERKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004414 +name: homoserine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine." [EC:2.3.1.31] +subset: gosubset_prok +synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] +synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31] +synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31] +synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] +synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31] +synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] +xref: EC:2.3.1.31 +xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0004415 +name: hyalurononglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] +subset: gosubset_prok +synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] +synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35] +synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35] +synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] +synonym: "hyaluronoglucosaminidase activity" EXACT [] +synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35] +xref: EC:3.2.1.35 +xref: MetaCyc:3.2.1.35-RXN +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0004416 +name: hydroxyacylglutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] +subset: gosubset_prok +synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6] +synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6] +synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6] +synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6] +xref: EC:3.1.2.6 +xref: MetaCyc:GLYOXII-RXN +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0004417 +name: hydroxyethylthiazole kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole." [EC:2.7.1.50] +subset: gosubset_prok +synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50] +synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50] +synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50] +xref: EC:2.7.1.50 +xref: MetaCyc:THIAZOLSYN3-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004418 +name: hydroxymethylbilane synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3." [EC:2.5.1.61] +comment: Note that this function was formerly EC:4.3.1.8. +subset: gosubset_prok +synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61] +synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] +synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61] +synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61] +synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61] +synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] +synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] +synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] +synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] +synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] +synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61] +xref: EC:2.5.1.61 +xref: MetaCyc:OHMETHYLBILANESYN-RXN +xref: Reactome:11374 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004419 +name: hydroxymethylglutaryl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate." [EC:4.1.3.4] +subset: gosubset_prok +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4] +synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4] +synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] +synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] +xref: EC:4.1.3.4 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN +xref: Reactome:74178 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0004420 +name: hydroxymethylglutaryl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+." [EC:1.1.1.34] +subset: gosubset_prok +synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] +synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] +xref: EC:1.1.1.34 +xref: MetaCyc:1.1.1.34-RXN +xref: Reactome:11408 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004421 +name: hydroxymethylglutaryl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA." [EC:2.3.3.10] +comment: Note that this function was formerly EC:4.1.3.5. +subset: gosubset_prok +synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10] +synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10] +synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10] +synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] +synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10] +synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] +synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] +synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10] +xref: EC:2.3.3.10 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN +xref: Reactome:74169 +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004422 +name: hypoxanthine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] +comment: Note that GO uses one molecular function term for consistency with Enzyme Nomenclature; also, all hypoxanthine phosphoribosyltransferases identified to date can act on either hypoxanthine or guanine, as well as xanthine or 6-mercaptopurine. +subset: gosubset_prok +synonym: "6-hydroxypurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "6-mercaptopurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "GPRT" RELATED [EC:2.4.2.8] +synonym: "guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "HGPRTase activity" EXACT [EC:2.4.2.8] +synonym: "HPRT" RELATED [EC:2.4.2.8] +synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8] +synonym: "purine-6-thiol phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] +synonym: "Transphosphoribosidase activity" EXACT [EC:2.4.2.8] +xref: EC:2.4.2.8 +xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN +xref: Reactome:11410 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004423 +name: iduronate-2-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] +subset: gosubset_prok +synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] +synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "iduronate-2-sulphatase activity" EXACT [] +synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13] +synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13] +synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13] +synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13] +xref: EC:3.1.6.13 +xref: MetaCyc:3.1.6.13-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004424 +name: imidazoleglycerol-phosphate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O." [EC:4.2.1.19] +subset: gosubset_prok +synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] +synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19] +synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19] +synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] +xref: EC:4.2.1.19 +xref: MetaCyc:IMIDPHOSDEHYD-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004425 +name: indole-3-glycerol-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] +subset: gosubset_prok +synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48] +synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] +synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48] +synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48] +synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48] +xref: EC:4.1.1.48 +xref: MetaCyc:IGPSYN-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004427 +name: inorganic diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + H2O = 2 phosphate." [EC:3.6.1.1] +subset: gosubset_prok +synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] +synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1] +synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] +xref: EC:3.6.1.1 +xref: MetaCyc:INORGPYROPHOSPHAT-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004428 +name: inositol or phosphatidylinositol kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] +subset: gosubset_prok +synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0004430 +name: 1-phosphatidylinositol 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate." [EC:2.7.1.67, PMID:9759495] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67] +synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] +synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] +synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] +synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67] +synonym: "PI kinase activity" BROAD [EC:2.7.1.67] +synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] +synonym: "PI4K" BROAD [EC:2.7.1.67] +synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] +synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] +synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] +xref: EC:2.7.1.67 +xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004432 +name: 1-phosphatidylinositol-4-phosphate kinase, class IA +namespace: molecular_function +def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418] +comment: This term was made obsolete because it is not a valid molecular function. +is_obsolete: true +consider: GO:0016308 + +[Term] +id: GO:0004433 +name: 1-phosphatidylinositol-4-phosphate kinase, class IB +namespace: molecular_function +def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418] +comment: This term was made obsolete because it is not a valid molecular function. +is_obsolete: true +consider: GO:0016308 + +[Term] +id: GO:0004434 +name: inositol or phosphatidylinositol phosphodiesterase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "inositol/phosphatidylinositol phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.- +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004435 +name: phosphoinositide phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." [EC:3.1.4.11] +subset: gosubset_prok +synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] +synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] +synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] +synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] +synonym: "phosphatidylinositol phospholipase C activity" EXACT [EC:3.1.4.11] +synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] +synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11] +synonym: "PI-PLC activity" EXACT [EC:3.1.4.11] +synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] +xref: EC:3.1.4.11 +xref: MetaCyc:3.1.4.11-RXN +is_a: GO:0004434 ! inositol or phosphatidylinositol phosphodiesterase activity +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0004436 +name: phosphatidylinositol diacylglycerol-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] +comment: Note that this function was formerly EC:3.1.4.10. +subset: gosubset_prok +synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] +synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] +synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] +synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] +synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] +xref: EC:4.6.1.13 +xref: MetaCyc:3.1.4.10-RXN +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0004437 +name: inositol or phosphatidylinositol phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] +subset: gosubset_prok +synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004438 +name: phosphatidylinositol-3-phosphatase activity +namespace: molecular_function +alt_id: GO:0016315 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] +comment: Note that this function includes EC:3.1.3.65. +synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] +synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] +synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64] +synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] +synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] +synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] +synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] +xref: EC:3.1.3.64 +xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0004439 +name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity +namespace: molecular_function +alt_id: GO:0001668 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36] +synonym: "inositol 1,4,5-triphosphate 5-phosphomonoesterase activity" EXACT [EC:3.1.3.36] +synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] +synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] +synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] +synonym: "PtdIns(4,5)P(2) phosphatase activity" EXACT [EC:3.1.3.36] +synonym: "PtdIns(4,5)P2 phosphatase activity" EXACT [EC:3.1.3.36] +synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] +synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] +xref: EC:3.1.3.36 +xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity +is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity + +[Term] +id: GO:0004441 +name: inositol-1,4-bisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] +synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57] +synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] +synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57] +xref: EC:3.1.3.57 +xref: MetaCyc:3.1.3.57-RXN +is_a: GO:0016312 ! inositol bisphosphate phosphatase activity + +[Term] +id: GO:0004442 +name: inositol-1,4,-bisphosphate 3-phosphatase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators] +is_obsolete: true +consider: GO:0004438 + +[Term] +id: GO:0004443 +name: inositol-1,4,-bisphosphate 4-phosphatase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators] +is_obsolete: true +consider: GO:0016316 + +[Term] +id: GO:0004444 +name: inositol-1,4,5-trisphosphate 1-phosphatase +namespace: molecular_function +def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb] +comment: This term was made obsolete because the existence of this function has not been established. +is_obsolete: true +consider: GO:0046030 + +[Term] +id: GO:0004445 +name: inositol-polyphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] +synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56] +synonym: "5PTase activity" RELATED [EC:3.1.3.56] +synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] +synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "inositol triphosphate 5-phosphomonoesterase activity" EXACT [] +synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56] +synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [] +synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] +synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] +synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] +synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] +xref: EC:3.1.3.56 +xref: MetaCyc:3.1.3.56-RXN +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:0004446 +name: multiple inositol-polyphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] +synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.62] +synonym: "inositol tetrakisphosphate phosphomonoesterase activity" EXACT [EC:3.1.3.62] +synonym: "MIPP activity" EXACT [EC:3.1.3.62] +xref: EC:3.1.3.62 +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0004447 +name: iodide peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O." [EC:1.11.1.8] +synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8] +synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8] +synonym: "iodinase activity" RELATED [EC:1.11.1.8] +synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8] +synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8] +synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] +synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] +synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] +synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] +synonym: "TPO activity" RELATED [EC:1.11.1.8] +synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8] +xref: EC:1.11.1.8 +xref: MetaCyc:IODIDE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004448 +name: isocitrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] +subset: gosubset_prok +synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] +synonym: "IDH activity" EXACT [EC:1.1.1.-] +synonym: "IDP activity" EXACT [EC:1.1.1.-] +synonym: "IDP1" RELATED [EC:1.1.1.-] +synonym: "IDP2" RELATED [EC:1.1.1.-] +synonym: "IDP3" RELATED [EC:1.1.1.-] +synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] +synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] +synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] +synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] +synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004449 +name: isocitrate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] +subset: gosubset_prok +synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] +synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] +synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] +synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] +synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] +synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] +synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] +synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] +xref: EC:1.1.1.41 +xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-(NAD+)-RXN +xref: Reactome:11496 +is_a: GO:0004448 ! isocitrate dehydrogenase activity + +[Term] +id: GO:0004450 +name: isocitrate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] +subset: gosubset_prok +synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42] +synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42] +synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42] +synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42] +synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42] +synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] +synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase- activity" RELATED [EC:1.1.1.42] +xref: EC:1.1.1.42 +xref: MetaCyc:ISOCITDEH-RXN +is_a: GO:0004448 ! isocitrate dehydrogenase activity + +[Term] +id: GO:0004451 +name: isocitrate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate = succinate + glyoxylate." [EC:4.1.3.1] +subset: gosubset_prok +synonym: "ICL activity" EXACT [EC:4.1.3.1] +synonym: "isocitrase activity" EXACT [EC:4.1.3.1] +synonym: "isocitratase activity" EXACT [EC:4.1.3.1] +synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1] +synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] +synonym: "isocitritase activity" EXACT [EC:4.1.3.1] +synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] +xref: EC:4.1.3.1 +xref: MetaCyc:ISOCIT-CLEAV-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0004452 +name: isopentenyl-diphosphate delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the isomerization of isopentenyl diphosphate into dimethylallyl diphosphate." [EC:5.3.3.2] +subset: gosubset_prok +synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2] +synonym: "ipp isomerase activity" EXACT [EC:5.3.3.2] +synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] +synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2] +synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2] +synonym: "isopentenylpyrophosphate Delta-isomerase activity" EXACT [EC:5.3.3.2] +synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] +synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] +xref: EC:5.3.3.2 +xref: MetaCyc:IPPISOM-RXN +xref: Reactome:11501 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004453 +name: juvenile-hormone esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352] +synonym: "JH esterase activity" EXACT [EC:3.1.1.59] +synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] +synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] +synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] +synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] +xref: EC:3.1.1.59 +xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0004454 +name: ketohexokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] +subset: gosubset_prok +synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3] +synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] +synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3] +xref: EC:2.7.1.3 +xref: MetaCyc:KETOHEXOKINASE-RXN +xref: Reactome:11506 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004455 +name: ketol-acid reductoisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] +subset: gosubset_prok +synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86] +synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86] +synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86] +synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86] +synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86] +synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86] +synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86] +synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86] +synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86] +synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] +synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] +xref: EC:1.1.1.86 +xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004456 +name: phosphogluconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O." [EC:4.2.1.12] +subset: gosubset_prok +synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12] +synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12] +synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12] +synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12] +synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12] +synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] +synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] +xref: EC:4.2.1.12 +xref: MetaCyc:PGLUCONDEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004457 +name: lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the oxidation of lactate to produce pyruvate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0004458 +name: D-lactate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] +subset: gosubset_prok +synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4] +synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4] +synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4] +synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4] +synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4] +synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] +synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] +xref: EC:1.1.2.4 +xref: MetaCyc:D-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0004459 +name: L-lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27] +subset: gosubset_prok +synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27] +synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27] +xref: EC:1.1.1.27 +xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN +xref: Reactome:11515 +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004460 +name: L-lactate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3] +subset: gosubset_prok +synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3] +synonym: "cytochrome b2" RELATED [] +synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] +synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3] +synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] +synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] +synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] +synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3] +synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] +synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3] +synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] +synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] +xref: EC:1.1.2.3 +xref: MetaCyc:L-LACTATE-DEHYDROGENASE-(CYTOCHROME)-RXN +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0004461 +name: lactose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] +synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22] +synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] +synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] +synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] +synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] +synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] +xref: EC:2.4.1.22 +xref: MetaCyc:LACTOSE-SYNTHASE-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0004462 +name: lactoylglutathione lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5] +subset: gosubset_prok +synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5] +synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5] +synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5] +synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5] +synonym: "glyoxylase I" RELATED [EC:4.4.1.5] +synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5] +synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5] +xref: EC:4.4.1.5 +xref: MetaCyc:GLYOXI-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004463 +name: leukotriene-A4 hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate." [EC:3.3.2.6] +subset: gosubset_prok +synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6] +synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6] +synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6] +synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6] +synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6] +synonym: "LTA4H" RELATED [EC:3.3.2.6] +xref: EC:3.3.2.6 +xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0004464 +name: leukotriene-C4 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione." [EC:2.5.1.37] +comment: Note that this function was EC:2.5.1.37. +synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20] +synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20] +synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] +synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] +synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20] +synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20] +synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20] +synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20] +synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20] +synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20] +synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20] +xref: EC:4.4.1.20 +xref: MetaCyc:LEUKOTRIENE-C(4)-SYNTHASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004465 +name: lipoprotein lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.34] +synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] +synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34] +synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34] +synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34] +synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] +synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34] +synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34] +synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34] +xref: EC:3.1.1.34 +xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN +xref: Reactome:11541 +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0016298 ! lipase activity + +[Term] +id: GO:0004466 +name: long-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13] +subset: gosubset_prok +synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] +synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] +synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] +synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13] +synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] +xref: EC:1.3.99.13 +xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0004467 +name: long-chain-fatty-acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [EC:6.2.1.3] +subset: gosubset_prok +synonym: "ACS3" NARROW [EC:6.2.1.3] +synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] +synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] +synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] +synonym: "FAA1" NARROW [EC:6.2.1.3] +synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] +synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] +synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] +synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] +synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] +synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] +synonym: "long-chain acyl-CoA synthetase activity" EXACT [] +synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] +synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] +synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] +synonym: "long-chain fatty acid activation" RELATED [] +synonym: "long-chain fatty acid-CoA ligase activity" EXACT [] +synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] +synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] +synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] +synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] +synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] +synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] +synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] +synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] +synonym: "thiokinase" RELATED [EC:6.2.1.3] +xref: EC:6.2.1.3 +xref: MetaCyc:ACYLCOASYN-RXN +xref: MetaCyc:PWY-5143 +xref: Reactome:11544 +xref: UM-BBD_enzymeID:e0025 +is_a: GO:0015645 ! fatty-acid ligase activity + +[Term] +id: GO:0004468 +name: lysine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] +subset: gosubset_prok +synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32] +synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] +synonym: "LAT activity" EXACT [EC:2.3.1.32] +synonym: "lysine acetyltransferase activity" EXACT [] +synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32] +synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] +xref: EC:2.3.1.32 +xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004470 +name: malic enzyme activity +namespace: molecular_function +def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] +is_a: GO:0016615 ! malate dehydrogenase activity + +[Term] +id: GO:0004471 +name: malate dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate." [EC:1.1.1.39] +subset: gosubset_prok +synonym: "'malic' enzyme" RELATED [EC:1.1.1.39] +synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] +synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.39] +synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.39] +xref: EC:1.1.1.39 +xref: MetaCyc:1.1.1.39-RXN +is_a: GO:0004470 ! malic enzyme activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004473 +name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.40] +subset: gosubset_prok +synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] +synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40] +synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40] +synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40] +synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40] +synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] +synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40] +synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40] +synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] +xref: EC:1.1.1.40 +xref: MetaCyc:MALIC-NADP-RXN +is_a: GO:0004470 ! malic enzyme activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004474 +name: malate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + glyoxylate = L-malate + CoA." [EC:2.3.3.9] +comment: Note that this function was formerly EC:4.1.3.2. +subset: gosubset_prok +synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9] +synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9] +synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9] +synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9] +synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9] +synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] +synonym: "malate synthetase activity" EXACT [EC:2.3.3.9] +synonym: "malic synthetase activity" EXACT [EC:2.3.3.9] +synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] +xref: EC:2.3.3.9 +xref: MetaCyc:MALSYN-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004475 +name: mannose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose." [EC:2.7.7.13] +subset: gosubset_prok +synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] +synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] +synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] +synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] +synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] +synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] +synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13] +synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] +xref: EC:2.7.7.13 +xref: MetaCyc:2.7.7.13-RXN +is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity + +[Term] +id: GO:0004476 +name: mannose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] +subset: gosubset_prok +synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8] +synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8] +synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8] +synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] +synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] +synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8] +synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8] +xref: EC:5.3.1.8 +xref: MetaCyc:MANNPISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004477 +name: methenyltetrahydrofolate cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] +subset: gosubset_prok +synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9] +synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9] +synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9] +xref: EC:3.5.4.9 +xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0004478 +name: methionine adenosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] +subset: gosubset_prok +synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] +synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6] +synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6] +synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] +synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] +synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] +synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6] +synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6] +synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] +xref: EC:2.5.1.6 +xref: MetaCyc:S-ADENMETSYN-RXN +xref: Reactome:11567 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004479 +name: methionyl-tRNA formyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] +subset: gosubset_prok +synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9] +synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9] +synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9] +synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] +synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9] +synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9] +synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9] +synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] +synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] +xref: EC:2.1.2.9 +xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0004481 +name: methylene-fatty-acyl-phospholipid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] +synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] +synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16] +synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] +xref: EC:2.1.1.16 +xref: MetaCyc:2.1.1.16-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004482 +name: mRNA (guanine-N7-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] +synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56] +synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] +synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] +synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56] +synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56] +xref: EC:2.1.1.56 +xref: MetaCyc:MRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN +xref: Reactome:72079 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0004483 +name: mRNA (nucleoside-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] +subset: gosubset_prok +synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57] +synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57] +synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] +synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] +xref: EC:2.1.1.57 +xref: MetaCyc:2.1.1.57-RXN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0004484 +name: mRNA guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] +synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] +synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] +synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] +synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] +synonym: "protein lambda2" RELATED [EC:2.7.7.50] +xref: EC:2.7.7.50 +xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN +xref: Reactome:80327 +is_a: GO:0008192 ! RNA guanylyltransferase activity + +[Term] +id: GO:0004485 +name: methylcrotonoyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-methylcrotonyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA." [EC:6.4.1.4] +subset: gosubset_prok +synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4] +synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4] +synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] +synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] +synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] +synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] +xref: EC:6.4.1.4 +xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN +xref: Reactome:11585 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0004486 +name: methylenetetrahydrofolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15] +subset: gosubset_prok +synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] +xref: EC:1.5.1.- +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004487 +name: methylenetetrahydrofolate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+." [EC:1.5.1.15] +synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] +synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15] +xref: EC:1.5.1.15 +xref: MetaCyc:1.5.1.15-RXN +is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase activity + +[Term] +id: GO:0004488 +name: methylenetetrahydrofolate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+." [EC:1.5.1.5] +subset: gosubset_prok +synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5] +synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5] +xref: EC:1.5.1.5 +xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN +is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase activity + +[Term] +id: GO:0004489 +name: methylenetetrahydrofolate reductase (NADPH) activity +namespace: molecular_function +alt_id: GO:0008702 +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] +comment: Includes EC 1.7.99.5. +subset: gosubset_prok +synonym: "1.7.99.5" RELATED [] +synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] +synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] +synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] +synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] +synonym: "MetF" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] +synonym: "MTHFR activity" BROAD [EC:1.5.1.20] +synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] +synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] +xref: EC:1.5.1.20 +xref: MetaCyc:1.5.1.20-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004490 +name: methylglutaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O." [EC:4.2.1.18] +subset: gosubset_prok +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18] +synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18] +synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18] +synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18] +xref: EC:4.2.1.18 +xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004491 +name: methylmalonate-semialdehyde dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] +subset: gosubset_prok +synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27] +synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27] +synonym: "MSDH activity" EXACT [EC:1.2.1.27] +xref: EC:1.2.1.27 +xref: MetaCyc:1.2.1.27-RXN +xref: Reactome:70889 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004492 +name: methylmalonyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41] +subset: gosubset_prok +synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] +synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41] +synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] +synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41] +xref: EC:4.1.1.41 +xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004493 +name: methylmalonyl-CoA epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = (S)-2-methyl-3-oxopropanoyl-CoA." [EC:5.1.99.1] +subset: gosubset_prok +synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] +synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] +synonym: "dl-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] +synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1] +synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] +synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] +xref: EC:5.1.99.1 +xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN +xref: Reactome:11610 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0004494 +name: methylmalonyl-CoA mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = succinyl-CoA." [EC:5.4.99.2] +subset: gosubset_prok +synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] +synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] +synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2] +synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2] +synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2] +synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2] +xref: EC:5.4.99.2 +xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN +xref: Reactome:11612 +xref: UM-BBD_enzymeID:e0575 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0004495 +name: mevaldate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004496 +name: mevalonate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate." [EC:2.7.1.36] +subset: gosubset_prok +synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] +synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] +synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] +synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36] +synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36] +synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36] +synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36] +synonym: "MVA kinase activity" EXACT [EC:2.7.1.36] +xref: EC:2.7.1.36 +xref: MetaCyc:MEVALONATE-KINASE-RXN +xref: Reactome:11620 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004497 +name: monooxygenase activity +namespace: molecular_function +def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004498 +name: calcidiol 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [EC:1.14.13.13] +synonym: "1-hydroxylase-25-hydroxyvitamin D3" RELATED [EC:1.14.13.13] +synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] +synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] +synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] +synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13] +synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] +synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13] +synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13] +synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] +synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13] +synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13] +synonym: "cytochrome P450 CYP27B" NARROW [] +xref: EC:1.14.13.13 +xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004499 +name: flavin-containing monooxygenase activity +namespace: molecular_function +alt_id: GO:0047076 +def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] +subset: gosubset_prok +synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11] +synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] +synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11] +synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11] +synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11] +synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] +synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] +synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] +synonym: "FMO activity" RELATED [EC:1.13.12.11] +synonym: "FMO-I" RELATED [EC:1.13.12.11] +synonym: "FMO-II" RELATED [EC:1.13.12.11] +synonym: "FMO1" RELATED [EC:1.13.12.11] +synonym: "FMO2" RELATED [EC:1.13.12.11] +synonym: "FMO3" RELATED [EC:1.13.12.11] +synonym: "FMO4" RELATED [EC:1.13.12.11] +synonym: "FMO5" RELATED [EC:1.13.12.11] +synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] +synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] +synonym: "N,N-dimethylaniline monooxygenase activity" EXACT [EC:1.13.12.11] +synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11] +synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] +xref: EC:1.14.13.8 +xref: MetaCyc:1.14.13.8-RXN +xref: Reactome:11625 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004500 +name: dopamine beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1] +subset: gosubset_prok +synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1] +synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1] +synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1] +synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1] +synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1] +synonym: "dopamine b-hydroxylase activity" EXACT [] +synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] +synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1] +synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1] +synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1] +synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] +synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1] +synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] +synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] +xref: EC:1.14.17.1 +xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN +is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004501 +name: ecdysone 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ecdysone + donor-H2 + O2 = 20-hydroxyecdysone + acceptor + H2O." [EC:1.14.99.22] +synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22] +synonym: "ecdysone 20-hydroxylase activity" EXACT [] +synonym: "ecdysone modification" BROAD [] +synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22] +xref: EC:1.14.99.22 +xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004502 +name: kynurenine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O." [EC:1.14.13.9] +subset: gosubset_prok +synonym: "kynurenine 3-hydroxylase activity" EXACT [] +synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9] +synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9] +synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9] +xref: EC:1.14.13.9 +xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN +xref: Reactome:12242 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004503 +name: monophenol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1] +subset: gosubset_prok +synonym: "catecholase" BROAD [EC:1.14.18.1] +synonym: "chlorogenic acid oxidase activity" EXACT [EC:1.14.18.1] +synonym: "chlorogenic oxidase activity" EXACT [EC:1.14.18.1] +synonym: "cresolase activity" EXACT [EC:1.14.18.1] +synonym: "dopa oxidase" BROAD [EC:1.14.18.1] +synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] +synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1] +synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1] +synonym: "monophenol oxygenase" EXACT [PMID:2494997] +synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] +synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] +synonym: "monophenolase activity" EXACT [EC:1.14.18.1] +synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1] +synonym: "o-diphenol oxidase activity" EXACT [EC:1.14.18.1] +synonym: "o-diphenol oxidoreductase" BROAD [EC:1.14.18.1] +synonym: "o-diphenol:O2 oxidoreductase activity" EXACT [EC:1.14.18.1] +synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.14.18.1] +synonym: "phenol oxidase activity" EXACT [] +synonym: "phenolase activity" BROAD [EC:1.14.18.1] +synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1] +synonym: "polyphenolase activity" EXACT [EC:1.14.18.1] +synonym: "prophenol oxidase" RELATED [] +synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1] +synonym: "tyrosinase activity" BROAD [EC:1.14.18.1] +synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1] +xref: EC:1.14.18.1 +xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN +is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004504 +name: peptidylglycine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] +subset: gosubset_prok +synonym: "PAM activity" EXACT [EC:1.14.17.3] +synonym: "PAM-A" RELATED [EC:1.14.17.3] +synonym: "PAM-B" RELATED [EC:1.14.17.3] +synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] +synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3] +synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3] +synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3] +synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] +synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3] +synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3] +synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3] +synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] +xref: EC:1.14.17.3 +xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN +is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004505 +name: phenylalanine 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1] +subset: gosubset_prok +synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1] +synonym: "PAH activity" EXACT [EC:1.14.16.1] +synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1] +synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1] +synonym: "phenylalanine hydroxylase activity" EXACT [] +xref: EC:1.14.16.1 +xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN +xref: Reactome:12249 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004506 +name: squalene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the formation of a 2,3-epoxide in squalene." [EC:1.14.99.7] +synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.99.7] +synonym: "squalene epoxidase activity" EXACT [EC:1.14.99.7] +synonym: "squalene hydroxylase activity" EXACT [] +synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.99.7] +synonym: "squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.7] +synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.99.7] +synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.99.7] +xref: EC:1.14.99.7 +xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN +xref: Reactome:12251 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004507 +name: steroid 11-beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] +synonym: "cytochrome P450 CYP11B1" NARROW [] +synonym: "cytochrome P450 CYP11B2" NARROW [] +synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] +synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4] +synonym: "steroid 11-beta-hydroxylase activity" EXACT [] +synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] +synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4] +synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4] +synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] +synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4] +xref: EC:1.14.15.4 +xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004508 +name: steroid 17-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9] +synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9] +synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9] +synonym: "cytochrome P450 CYP17" NARROW [] +synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9] +synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9] +synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] +synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] +synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] +synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9] +synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9] +synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] +synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9] +xref: EC:1.14.99.9 +xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004509 +name: steroid 21-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10] +synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10] +synonym: "cytochrome P450 CYP21A1" NARROW [] +synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10] +synonym: "steroid 21-hydroxylase activity" EXACT [] +synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10] +xref: EC:1.14.99.10 +xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004510 +name: tryptophan 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] +synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4] +synonym: "L-tryptophan hydroxylase activity" EXACT [] +synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4] +synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4] +synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4] +xref: EC:1.14.16.4 +xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004511 +name: tyrosine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] +synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2] +synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2] +synonym: "tyrosine 3-hydroxylase activity" EXACT [] +synonym: "tyrosine hydroxylase activity" EXACT [] +xref: EC:1.14.16.2 +xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004512 +name: inositol-3-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4] +subset: gosubset_prok +synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4] +synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4] +synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4] +synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4] +synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4] +synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4] +synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4] +synonym: "myo-inositol-1-phosphate synthase activity" EXACT [] +xref: EC:5.5.1.4 +xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0004513 +name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] +synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10] +synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10] +synonym: "SAT-3" RELATED [EC:2.4.99.10] +synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] +xref: EC:2.4.99.10 +xref: MetaCyc:2.4.99.10-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0004514 +name: nicotinate-nucleotide diphosphorylase (carboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.19] +subset: gosubset_prok +synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19] +synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19] +synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] +synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19] +synonym: "QAPRTase activity" EXACT [EC:2.4.2.19] +synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19] +synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] +synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] +xref: EC:2.4.2.19 +xref: MetaCyc:QUINOPRIBOTRANS-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004515 +name: nicotinate-nucleotide adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] +subset: gosubset_prok +synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] +synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] +synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18] +synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18] +synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18] +synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18] +synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18] +synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] +synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] +xref: EC:2.7.7.18 +xref: MetaCyc:NICONUCADENYLYLTRAN-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004516 +name: nicotinate phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.11] +subset: gosubset_prok +synonym: "niacin ribonucleotidase activity" EXACT [EC:2.4.2.11] +synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.11] +synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:2.4.2.11] +synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.11] +synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.11] +xref: EC:2.4.2.11 +xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004517 +name: nitric-oxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] +subset: gosubset_prok +synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] +synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] +synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39] +synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39] +synonym: "nitric oxide synthase activity" EXACT [] +synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39] +synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39] +synonym: "NO synthase activity" EXACT [EC:1.14.13.39] +xref: EC:1.14.13.39 +xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004518 +name: nuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] +comment: Consider also annotating to the molecular function term 'nucleic acid binding ; GO:0003676'. Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +xref: EC:3.1.-.- +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0004519 +name: endonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +xref: Reactome:3138 +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0004520 +name: endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "endonuclease G activity" NARROW [] +xref: Reactome:3136 +is_a: GO:0004519 ! endonuclease activity +is_a: GO:0004536 ! deoxyribonuclease activity + +[Term] +id: GO:0004521 +name: endoribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "endonuclease G activity" NARROW [] +is_a: GO:0004519 ! endonuclease activity +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0004522 +name: pancreatic ribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5] +synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5] +synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5] +synonym: "endoribonuclease I" RELATED [EC:3.1.27.5] +synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5] +synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5] +synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5] +synonym: "ribonuclease A" EXACT [] +synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5] +synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5] +synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5] +synonym: "RNase A activity" EXACT [EC:3.1.27.5] +synonym: "RNase activity" BROAD [EC:3.1.27.5] +synonym: "RNase I activity" EXACT [EC:3.1.27.5] +synonym: "S-genotype-assocd. glycoproteins" RELATED [EC:3.1.27.5] +synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5] +xref: EC:3.1.27.5 +xref: MetaCyc:3.1.27.5-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0004523 +name: ribonuclease H activity +namespace: molecular_function +alt_id: GO:0004524 +def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] +comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. +subset: gosubset_prok +synonym: "calf thymus ribonuclease H activity" EXACT [] +synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] +synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] +synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] +synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4] +synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4] +synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4] +synonym: "hybridase activity" EXACT [EC:3.1.26.4] +synonym: "ribonuclease H1 activity" NARROW [] +synonym: "ribonuclease H2 activity" NARROW [] +synonym: "ribonuclease H3 activity" NARROW [] +synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4] +synonym: "RNase H activity" EXACT [] +synonym: "RNase H1 activity" NARROW [] +synonym: "RNase H2 activity" NARROW [] +synonym: "RNase H3 activity" NARROW [] +xref: EC:3.1.26.4 +xref: MetaCyc:3.1.26.4-RXN +xref: Reactome:12321 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004525 +name: ribonuclease III activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] +subset: gosubset_prok +synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] +synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3] +synonym: "RNase III activity" EXACT [EC:3.1.26.3] +xref: EC:3.1.26.3 +xref: MetaCyc:3.1.26.3-RXN +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004526 +name: ribonuclease P activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] +subset: gosubset_prok +synonym: "RNase P" EXACT [] +synonym: "tRNA 5' leader endonuclease activity" EXACT [] +xref: EC:3.1.26.5 +xref: MetaCyc:3.1.26.5-RXN +is_a: GO:0004549 ! tRNA-specific ribonuclease activity +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004527 +name: exonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0004528 +name: phosphodiesterase I activity +namespace: molecular_function +def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] +subset: gosubset_prok +synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] +synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] +synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] +synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] +synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] +synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] +synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] +synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] +synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] +synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] +synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] +synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] +synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] +synonym: "PDE I activity" EXACT [EC:3.1.4.1] +synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] +xref: EC:3.1.4.1 +xref: MetaCyc:3.1.4.1-RXN +is_a: GO:0004527 ! exonuclease activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004529 +name: exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0004527 ! exonuclease activity +is_a: GO:0004536 ! deoxyribonuclease activity + +[Term] +id: GO:0004530 +name: deoxyribonuclease I activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] +subset: gosubset_prok +synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1] +synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1] +synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] +synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] +synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1] +synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1] +synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1] +synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1] +synonym: "DNAase activity" EXACT [EC:3.1.21.1] +synonym: "DNase activity" NARROW [EC:3.1.21.1] +synonym: "DNase I" RELATED [EC:3.1.21.1] +synonym: "dornava" RELATED [EC:3.1.21.1] +synonym: "dornavac" RELATED [EC:3.1.21.1] +synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] +synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] +synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] +synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] +synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] +synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] +synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1] +xref: EC:3.1.21.1 +xref: MetaCyc:3.1.21.1-RXN +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004531 +name: deoxyribonuclease II activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] +subset: gosubset_prok +synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1] +synonym: "acid DNase activity" EXACT [EC:3.1.22.1] +synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1] +synonym: "DNase II activity" EXACT [EC:3.1.22.1] +synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] +synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] +xref: EC:3.1.22.1 +xref: MetaCyc:3.1.22.1-RXN +is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0004532 +name: exoribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0004527 ! exonuclease activity +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0004533 +name: exoribonuclease H activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] +synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] +xref: EC:3.1.13.2 +xref: MetaCyc:3.1.13.2-RXN +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004534 +name: 5'-3' exoribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] +xref: EC:3.1.13.- +is_a: GO:0008409 ! 5'-3' exonuclease activity +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004535 +name: poly(A)-specific ribonuclease activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] +synonym: "2',3'-exoribonuclease activity" EXACT [EC:3.1.13.4] +synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4] +synonym: "poly(A)-specific RNase activity" EXACT [] +xref: EC:3.1.13.4 +xref: MetaCyc:3.1.13.4-RXN +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004536 +name: deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] +comment: Consider also annotating to the molecular function term 'DNA binding ; GO:0003677'. +subset: gosubset_prok +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0004537 +name: caspase-activated deoxyribonuclease activity +namespace: molecular_function +is_a: GO:0004536 ! deoxyribonuclease activity + +[Term] +id: GO:0004540 +name: ribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] +comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'. +subset: gosubset_prok +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0004549 +name: tRNA-specific ribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] +subset: gosubset_prok +synonym: "tRNA-specific RNase activity" EXACT [] +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0004550 +name: nucleoside diphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] +subset: gosubset_prok +synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] +synonym: "NDK activity" EXACT [EC:2.7.4.6] +synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] +synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] +synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] +synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] +synonym: "nucleoside-diphosphate kinase activity" EXACT [] +synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] +synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] +synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] +xref: EC:2.7.4.6 +xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN +xref: Reactome:12403 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0004551 +name: nucleotide diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] +subset: gosubset_prok +synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] +synonym: "nucleotide pyrophosphatase activity" EXACT [] +synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] +xref: EC:3.6.1.9 +xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004552 +name: octanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + NADH + H+." [EC:1.1.1.73] +synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73] +synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73] +xref: EC:1.1.1.73 +xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004553 +name: hydrolase activity, hydrolyzing O-glycosyl compounds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] +subset: gosubset_prok +synonym: "O-glucosyl hydrolase activity" EXACT [] +xref: EC:3.2.1 +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0004555 +name: alpha,alpha-trehalase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] +subset: gosubset_prok +synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] +xref: EC:3.2.1.28 +xref: MetaCyc:TREHALA-RXN +xref: Reactome:12414 +is_a: GO:0015927 ! trehalase activity + +[Term] +id: GO:0004556 +name: alpha-amylase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units." [EC:3.2.1.1] +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1] +synonym: "alpha amylase activity" EXACT [EC:3.2.1.1] +synonym: "endoamylase activity" EXACT [EC:3.2.1.1] +synonym: "glycogenase activity" BROAD [EC:3.2.1.1] +synonym: "taka-amylase A" RELATED [EC:3.2.1.1] +xref: EC:3.2.1.1 +xref: MetaCyc:3.2.1.1-RXN +xref: Reactome:12418 +is_a: GO:0016160 ! amylase activity + +[Term] +id: GO:0004557 +name: alpha-galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] +subset: gosubset_prok +synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] +synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] +synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] +synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] +synonym: "melibiase activity" EXACT [] +xref: EC:3.2.1.22 +xref: MetaCyc:ALPHAGALACTOSID-RXN +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0004558 +name: alpha-glucosidase activity +namespace: molecular_function +alt_id: GO:0004562 +alt_id: GO:0016982 +def: "Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] +subset: gosubset_prok +synonym: "acid maltase activity" EXACT [EC:3.2.1.20] +synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] +synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] +synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] +synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] +synonym: "alpha-glucosidase II" RELATED [] +synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] +synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] +synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] +synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] +synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] +synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] +xref: EC:3.2.1.20 +xref: MetaCyc:3.2.1.20-RXN +xref: Reactome:12426 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004559 +name: alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] +subset: gosubset_prok +synonym: "1,2-alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] +synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.24] +synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24] +synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] +synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24] +synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24] +synonym: "p-nitrophenyl-alpha-mannosidase activity" EXACT [EC:3.2.1.24] +xref: EC:3.2.1.24 +xref: MetaCyc:3.2.1.24-RXN +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0004560 +name: alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] +subset: gosubset_prok +synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51] +synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] +xref: EC:3.2.1.51 +xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN +is_a: GO:0015928 ! fucosidase activity + +[Term] +id: GO:0004561 +name: alpha-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] +synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50] +synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50] +synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50] +synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50] +synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50] +synonym: "NAG activity" EXACT [EC:3.2.1.50] +xref: EC:3.2.1.50 +xref: MetaCyc:3.2.1.50-RXN +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0004563 +name: beta-N-acetylhexosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] +subset: gosubset_prok +synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52] +synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52] +synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52] +synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] +synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52] +synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] +xref: EC:3.2.1.52 +xref: MetaCyc:3.2.1.52-RXN +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0004564 +name: beta-fructofuranosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides." [EC:3.2.1.26] +subset: gosubset_prok +synonym: "acid invertase activity" EXACT [] +synonym: "alkaline invertase activity" EXACT [] +synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] +synonym: "beta-fructosidase activity" BROAD [] +synonym: "beta-h-fructosidase activity" EXACT [] +synonym: "fructosylinvertase activity" EXACT [] +synonym: "glucosucrase activity" EXACT [] +synonym: "invertase activity" BROAD [] +synonym: "invertin activity" BROAD [] +synonym: "maxinvert L 1000 activity" EXACT [] +synonym: "saccharase activity" EXACT [] +synonym: "sucrase activity" BROAD [] +xref: EC:3.2.1.26 +xref: MetaCyc:3.2.1.26-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004565 +name: beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] +comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. +subset: gosubset_prok +synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23] +synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23] +synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23] +synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23] +synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23] +synonym: "hydrolact" RELATED [EC:3.2.1.23] +synonym: "lactose hydrolysis" RELATED [] +synonym: "lactozym" RELATED [EC:3.2.1.23] +synonym: "maxilact" RELATED [EC:3.2.1.23] +synonym: "oryzatym" RELATED [EC:3.2.1.23] +synonym: "S 2107" RELATED [EC:3.2.1.23] +synonym: "sumiklat" RELATED [EC:3.2.1.23] +synonym: "trilactase activity" EXACT [EC:3.2.1.23] +xref: EC:3.2.1.23 +xref: MetaCyc:3.2.1.23-RXN +xref: MetaCyc:BGALACT-PWY +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0004566 +name: beta-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] +subset: gosubset_prok +synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31] +synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31] +synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31] +synonym: "glucuronidase activity" EXACT [EC:3.2.1.31] +synonym: "ketodase activity" EXACT [EC:3.2.1.31] +xref: EC:3.2.1.31 +xref: MetaCyc:BETA-GLUCURONID-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004567 +name: beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] +subset: gosubset_prok +synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25] +synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] +synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] +synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25] +synonym: "mannanase activity" EXACT [EC:3.2.1.25] +synonym: "mannase activity" EXACT [EC:3.2.1.25] +xref: EC:3.2.1.25 +xref: MetaCyc:3.2.1.25-RXN +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0004568 +name: chitinase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins." [EC:3.2.1.14] +subset: gosubset_prok +synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14] +synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14] +synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14] +synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14] +synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14] +xref: EC:3.2.1.14 +xref: MetaCyc:3.2.1.14-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004569 +name: glycoprotein endo-alpha-1,2-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] +synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130] +synonym: "endomannosidase activity" EXACT [EC:3.2.1.130] +synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130] +synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130] +synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] +xref: EC:3.2.1.130 +xref: MetaCyc:3.2.1.130-RXN +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0004571 +name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] +subset: gosubset_prok +synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.113] +synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113] +synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113] +synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] +synonym: "man9-mannosidase activity" RELATED [EC:3.2.1.113] +synonym: "Man9-mannosidase activity" EXACT [EC:3.2.1.113] +synonym: "ManI activity" NARROW [EC:3.2.1.113] +synonym: "mannose-9 processing alpha-mannosidase activity" EXACT [EC:3.2.1.113] +synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] +synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] +synonym: "mannosidase I" RELATED [EC:3.2.1.113] +xref: EC:3.2.1.113 +xref: MetaCyc:3.2.1.113-RXN +is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity + +[Term] +id: GO:0004572 +name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] +synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114] +synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] +synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] +synonym: "alpha1-3,6-mannosidase activity" EXACT [EC:3.2.1.114] +synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114] +synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114] +synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] +synonym: "ManII activity" NARROW [EC:3.2.1.114] +synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] +xref: EC:3.2.1.114 +xref: MetaCyc:3.2.1.114-RXN +is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity + +[Term] +id: GO:0004573 +name: mannosyl-oligosaccharide glucosidase activity +namespace: molecular_function +def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] +synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106] +synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106] +synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] +synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] +synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106] +xref: EC:3.2.1.106 +xref: MetaCyc:3.2.1.106-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004574 +name: oligo-1,6-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose." [EC:3.2.1.10] +subset: gosubset_prok +synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10] +synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10] +synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10] +synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10] +synonym: "isomaltase activity" RELATED [EC:3.2.1.10] +synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10] +synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10] +synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10] +synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] +xref: EC:3.2.1.10 +xref: MetaCyc:3.2.1.10-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004575 +name: sucrose alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action." [EC:3.2.1.48] +synonym: "intestinal sucrase activity" EXACT [EC:3.2.1.48] +synonym: "sucrase activity" EXACT [EC:3.2.1.48] +synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] +synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48] +synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] +synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48] +synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48] +synonym: "sucrose.alpha.-glucohydrolase activity" EXACT [EC:3.2.1.48] +xref: EC:3.2.1.48 +xref: MetaCyc:3.2.1.48-RXN +xref: Reactome:12493 +is_a: GO:0004558 ! alpha-glucosidase activity + +[Term] +id: GO:0004576 +name: oligosaccharyl transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +subset: gosubset_prok +xref: EC:2.4.1.- +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0004577 +name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] +synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141] +synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141] +synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141] +synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141] +xref: EC:2.4.1.141 +xref: MetaCyc:2.4.1.141-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0004578 +name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] +synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] +synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142] +synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] +xref: EC:2.4.1.142 +xref: MetaCyc:2.4.1.142-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004579 +name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] +synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119] +synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] +synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119] +synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] +synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] +synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] +synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] +synonym: "oligomannosyltransferase activity" EXACT [EC:2.4.1.119] +synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119] +xref: EC:2.4.1.119 +xref: MetaCyc:2.4.1.119-RXN +is_a: GO:0004576 ! oligosaccharyl transferase activity + +[Term] +id: GO:0004581 +name: dolichyl-phosphate beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] +subset: gosubset_prok +synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] +synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117] +xref: EC:2.4.1.117 +xref: MetaCyc:2.4.1.117-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0004582 +name: dolichyl-phosphate beta-D-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] +subset: gosubset_prok +synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83] +synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] +synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] +synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83] +synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] +synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83] +synonym: "DPM synthase activity" EXACT [] +synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] +synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83] +synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83] +xref: EC:2.4.1.83 +xref: MetaCyc:2.4.1.83-RXN +xref: Reactome:12521 +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004583 +name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity +namespace: molecular_function +xref: EC:2.4.1.- +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0004584 +name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] +synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130] +synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130] +synonym: "oligomannosylsynthase activity" EXACT [EC:2.4.1.130] +xref: EC:2.4.1.130 +xref: MetaCyc:2.4.1.130-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004585 +name: ornithine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] +subset: gosubset_prok +synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] +synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] +synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] +synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] +synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] +synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] +synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] +synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] +synonym: "OTC activity" EXACT [EC:2.1.3.3] +synonym: "OTCase activity" EXACT [EC:2.1.3.3] +xref: EC:2.1.3.3 +xref: MetaCyc:ORNCARBAMTRANSFER-RXN +xref: Reactome:12530 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0004586 +name: ornithine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine = putrescine + CO2." [EC:4.1.1.17] +subset: gosubset_prok +synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17] +synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] +synonym: "SpeC" RELATED [EC:4.1.1.17] +xref: EC:4.1.1.17 +xref: MetaCyc:ORNDECARBOX-RXN +xref: Reactome:12531 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004587 +name: ornithine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] +subset: gosubset_prok +synonym: "GabT" RELATED [EC:2.6.1.13] +synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "OAT" RELATED [EC:2.6.1.13] +synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13] +synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] +synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13] +xref: EC:2.6.1.13 +xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN +xref: Reactome:12532 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004588 +name: orotate phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] +subset: gosubset_prok +synonym: "OPRT activity" EXACT [EC:2.4.2.10] +synonym: "OPRTase activity" EXACT [EC:2.4.2.10] +synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10] +synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] +synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] +synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10] +synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] +synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10] +synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10] +xref: EC:2.4.2.10 +xref: MetaCyc:OROPRIBTRANS-RXN +xref: Reactome:12534 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004589 +name: orotate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + NAD+ = orotate + NADH + H+." [EC:1.3.1.14] +synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14] +xref: EC:1.3.1.14 +xref: MetaCyc:OROTATE-REDUCTASE-(NADH)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004590 +name: orotidine-5'-phosphate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2." [EC:4.1.1.23] +subset: gosubset_prok +synonym: "ODCase activity" EXACT [EC:4.1.1.23] +synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "OMP-DC" RELATED [EC:4.1.1.23] +synonym: "OMPdcase activity" EXACT [EC:4.1.1.23] +synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23] +synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23] +synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23] +synonym: "UMP synthase activity" EXACT [EC:4.1.1.23] +synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23] +xref: EC:4.1.1.23 +xref: MetaCyc:OROTPDECARB-RXN +xref: Reactome:12548 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004591 +name: oxoglutarate dehydrogenase (succinyl-transferring) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] +subset: gosubset_prok +synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2] +synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2] +synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2] +synonym: "AKGDH activity" EXACT [EC:1.2.4.2] +synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] +synonym: "OGDC activity" EXACT [EC:1.2.4.2] +synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2] +synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] +synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] +xref: EC:1.2.4.2 +xref: MetaCyc:RXN0-1146 +is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + +[Term] +id: GO:0004592 +name: pantoate-beta-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] +subset: gosubset_prok +synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] +synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] +synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] +synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] +synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1] +xref: EC:6.3.2.1 +xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004593 +name: pantothenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pantothenate + H2O = pantoate + beta-alanine." [EC:3.5.1.22] +synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] +synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] +synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22] +xref: EC:3.5.1.22 +xref: MetaCyc:PANTOTHENASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004594 +name: pantothenate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] +subset: gosubset_prok +synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] +synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] +synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33] +synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33] +synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33] +xref: EC:2.7.1.33 +xref: MetaCyc:PANTOTHENATE-KIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004595 +name: pantetheine-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = diphosphate + dephospho-CoA." [EC:2.7.7.3] +subset: gosubset_prok +synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] +synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] +synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] +synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3] +synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] +synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3] +synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] +synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] +synonym: "PPAT activity" EXACT [EC:2.7.7.3] +xref: EC:2.7.7.3 +xref: MetaCyc:PANTEPADENYLYLTRAN-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004596 +name: peptide alpha-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the acetylation of the N-terminal amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide." [EC:2.3.1.88, GOC:mah] +subset: gosubset_prok +synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88] +synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] +synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88] +synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88] +synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88] +synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] +synonym: "NAT activity" RELATED [EC:2.3.1.88] +synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88] +synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88] +xref: EC:2.3.1.88 +xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN +is_a: GO:0034212 ! peptide N-acetyltransferase activity + +[Term] +id: GO:0004597 +name: peptide-aspartate beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] +subset: gosubset_prok +synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16] +synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] +synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16] +synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16] +xref: EC:1.14.11.16 +xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0004598 +name: peptidylamidoglycolate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] +synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5] +synonym: "HGAD" RELATED [EC:4.3.2.5] +synonym: "PAL" RELATED [EC:4.3.2.5] +synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5] +synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5] +synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5] +synonym: "PGL" RELATED [EC:4.3.2.5] +xref: EC:4.3.2.5 +xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0004600 +name: cyclophilin +namespace: molecular_function +def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0003755 +consider: GO:0016018 + +[Term] +id: GO:0004601 +name: peroxidase activity +namespace: molecular_function +alt_id: GO:0016685 +alt_id: GO:0016686 +alt_id: GO:0016687 +def: "Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.7] +subset: gosubset_prok +synonym: "bacterial catalase-peroxidase activity" NARROW [] +synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] +synonym: "eosinophil peroxidase activity" NARROW [] +synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] +synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] +synonym: "heme peroxidase" NARROW [EC:1.11.1.7] +synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] +synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] +synonym: "lactoperoxidase activity" NARROW [] +synonym: "MPO" RELATED [EC:1.11.1.7] +synonym: "myeloperoxidase activity" NARROW [] +synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] +synonym: "peroxidase reaction" EXACT [] +synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] +synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] +synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] +synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] +synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] +xref: EC:1.11.1.7 +xref: MetaCyc:PEROXID-RXN +xref: Reactome:4411 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:0004602 +name: glutathione peroxidase activity +namespace: molecular_function +alt_id: GO:0016224 +def: "Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O." [EC:1.11.1.9] +subset: gosubset_prok +synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] +synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] +synonym: "non-selenium glutathione peroxidase activity" NARROW [] +synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] +synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] +xref: EC:1.11.1.9 +xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN +xref: Reactome:13237 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004603 +name: phenylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] +synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28] +synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28] +synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28] +synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28] +synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] +synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] +xref: EC:2.1.1.28 +xref: MetaCyc:2.1.1.28-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004604 +name: phosphoadenylyl-sulfate reductase (thioredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8] +subset: gosubset_prok +synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8] +synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] +synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] +synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8] +synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8] +synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8] +synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8] +synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] +synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] +synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8] +synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] +xref: EC:1.8.4.8 +xref: MetaCyc:1.8.4.8-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0004605 +name: phosphatidate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] +subset: gosubset_prok +synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] +synonym: "CDP-DG" RELATED [EC:2.7.7.41] +synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41] +synonym: "CDP-diacylglycerol synthase activity" EXACT [] +synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] +synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] +synonym: "CDP-diglyceride synthase activity" EXACT [] +synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41] +synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41] +synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41] +synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41] +synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] +synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41] +synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41] +synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41] +xref: EC:2.7.7.41 +xref: MetaCyc:CDPDIGLYSYN-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004607 +name: phosphatidylcholine-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] +subset: gosubset_prok +synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] +synonym: "LCAT activity" EXACT [EC:2.3.1.43] +synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] +synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] +synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43] +synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] +xref: EC:2.3.1.43 +xref: MetaCyc:2.3.1.43-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004608 +name: phosphatidylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17] +subset: gosubset_prok +synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17] +synonym: "LMTase activity" EXACT [EC:2.1.1.17] +synonym: "PEMT" RELATED [EC:2.1.1.17] +synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17] +synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17] +synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17] +synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17] +xref: EC:2.1.1.17 +xref: MetaCyc:2.1.1.17-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004609 +name: phosphatidylserine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2." [EC:4.1.1.65] +subset: gosubset_prok +synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65] +synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65] +synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65] +xref: EC:4.1.1.65 +xref: MetaCyc:PHOSPHASERDECARB-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004610 +name: phosphoacetylglucosamine mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3] +subset: gosubset_prok +synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3] +synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3] +synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] +synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] +synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3] +synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3] +xref: EC:5.4.2.3 +xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004611 +name: phosphoenolpyruvate carboxykinase activity +namespace: molecular_function +def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2." [EC:4.1.1.-] +subset: gosubset_prok +synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.-] +synonym: "PEPCK activity" EXACT [EC:4.1.1.-] +synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.-] +xref: EC:4.1.1.- +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004612 +name: phosphoenolpyruvate carboxykinase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2." [EC:4.1.1.49] +subset: gosubset_prok +synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49] +synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49] +synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] +synonym: "PEPK" RELATED [EC:4.1.1.49] +synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] +synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] +synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] +synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49] +synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] +xref: EC:4.1.1.49 +xref: MetaCyc:PEPCARBOXYKIN-RXN +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0004613 +name: phosphoenolpyruvate carboxykinase (GTP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] +subset: gosubset_prok +synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32] +synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32] +synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] +synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] +synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32] +synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32] +synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32] +synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32] +xref: EC:4.1.1.32 +xref: MetaCyc:4.1.1.32-RXN +xref: Reactome:13265 +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0004614 +name: phosphoglucomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] +subset: gosubset_prok +synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2] +synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2] +synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2] +xref: EC:5.4.2.2 +xref: MetaCyc:PHOSPHOGLUCMUT-RXN +xref: Reactome:13266 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004615 +name: phosphomannomutase activity +namespace: molecular_function +alt_id: GO:0008971 +def: "Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8] +subset: gosubset_prok +synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] +synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] +synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8] +synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8] +xref: EC:5.4.2.8 +xref: MetaCyc:PHOSMANMUT-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004616 +name: phosphogluconate dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] +subset: gosubset_prok +synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44] +synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44] +synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44] +synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44] +synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] +synonym: "6PGD activity" EXACT [EC:1.1.1.44] +synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44] +xref: EC:1.1.1.44 +xref: MetaCyc:6PGLUCONDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004617 +name: phosphoglycerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] +subset: gosubset_prok +synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] +synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] +synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95] +synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95] +synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95] +synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] +synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95] +synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "PGDH activity" EXACT [EC:1.1.1.95] +synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95] +synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] +synonym: "SerA" RELATED [EC:1.1.1.95] +synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] +xref: EC:1.1.1.95 +xref: MetaCyc:PGLYCDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004618 +name: phosphoglycerate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.3] +subset: gosubset_prok +synonym: "3-PGK" RELATED [EC:2.7.2.3] +synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3] +synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3] +synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] +synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3] +synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] +synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3] +synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] +synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] +synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3] +synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3] +synonym: "PGK" RELATED [EC:2.7.2.3] +synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] +synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] +synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3] +xref: EC:2.7.2.3 +xref: MetaCyc:PHOSGLYPHOS-RXN +xref: Reactome:13282 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0004619 +name: phosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] +subset: gosubset_prok +synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] +synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] +synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] +synonym: "GriP mutase" NARROW [EC:5.4.2.1] +synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] +synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] +synonym: "MPGM" RELATED [EC:5.4.2.1] +synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] +synonym: "PGAM activity" EXACT [EC:5.4.2.1] +synonym: "PGM" EXACT [] +synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] +synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] +xref: EC:5.4.2.1 +xref: MetaCyc:3PGAREARR-RXN +xref: Reactome:13285 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004620 +name: phospholipase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.1.1.- +is_a: GO:0016298 ! lipase activity + +[Term] +id: GO:0004621 +name: glycosylphosphatidylinositol phospholipase D activity +namespace: molecular_function +def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] +synonym: "glycoprotein phospholipase D activity" EXACT [] +synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50] +synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50] +synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50] +synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50] +synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50] +xref: EC:3.1.4.50 +xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN +is_a: GO:0004630 ! phospholipase D activity + +[Term] +id: GO:0004622 +name: lysophospholipase activity +namespace: molecular_function +alt_id: GO:0045126 +def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] +subset: gosubset_prok +synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] +synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] +synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] +synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] +synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] +synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] +synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] +synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] +synonym: "phosphatidase B" RELATED [EC:3.1.1.5] +synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] +xref: EC:3.1.1.5 +xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0004620 ! phospholipase activity + +[Term] +id: GO:0004623 +name: phospholipase A2 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] +subset: gosubset_prok +synonym: "cytosolic phospholipase A2 activity" NARROW [] +synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] +synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] +synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] +synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] +synonym: "phospholipase A" RELATED [EC:3.1.1.4] +synonym: "secreted phospholipase A2 activity" NARROW [] +xref: EC:3.1.1.4 +xref: MetaCyc:PHOSPHOLIPASE-A2-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0004620 ! phospholipase activity + +[Term] +id: GO:0004624 +name: secreted phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +is_obsolete: true +replaced_by: GO:0004623 +replaced_by: GO:0005576 + +[Term] +id: GO:0004625 +name: calcium-dependent secreted phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +is_obsolete: true +replaced_by: GO:0005576 +replaced_by: GO:0047498 + +[Term] +id: GO:0004626 +name: cytosolic phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +is_obsolete: true +replaced_by: GO:0004623 +replaced_by: GO:0005829 + +[Term] +id: GO:0004627 +name: calcium-dependent cytosolic phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +is_obsolete: true +replaced_by: GO:0005829 +replaced_by: GO:0047498 + +[Term] +id: GO:0004628 +name: calcium-independent cytosolic phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +is_obsolete: true +replaced_by: GO:0005829 +replaced_by: GO:0047499 + +[Term] +id: GO:0004629 +name: phospholipase C activity +namespace: molecular_function +alt_id: GO:0042298 +def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah] +subset: gosubset_prok +synonym: "lecithinase C activity" RELATED [EC:3.1.4.3] +synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] +synonym: "phosphatidase C" RELATED [EC:3.1.4.3] +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004630 +name: phospholipase D activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] +subset: gosubset_prok +synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] +synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] +synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] +synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] +xref: EC:3.1.4.4 +xref: MetaCyc:PHOSPHOLIPASE-D-RXN +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004631 +name: phosphomevalonate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate." [EC:2.7.4.2] +subset: gosubset_prok +synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2] +synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] +synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] +synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2] +synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2] +synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2] +xref: EC:2.7.4.2 +xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN +xref: Reactome:13380 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0004632 +name: phosphopantothenate--cysteine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] +subset: gosubset_prok +synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5] +synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] +synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] +xref: EC:6.3.2.5 +xref: MetaCyc:P-PANTOCYSLIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004633 +name: phosphopantothenoylcysteine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-((R)-4-phosphopantothenoyl)-L-cysteine = pantetheine 4'-phosphate + CO2." [EC:4.1.1.36] +subset: gosubset_prok +synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36] +synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36] +synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] +synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36] +synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] +synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36] +xref: EC:4.1.1.36 +xref: MetaCyc:P-PANTOCYSDECARB-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004634 +name: phosphopyruvate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] +synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11] +synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11] +synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] +synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11] +synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11] +synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11] +synonym: "enolase activity" EXACT [EC:4.2.1.11] +synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11] +synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] +synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11] +xref: EC:4.2.1.11 +xref: MetaCyc:2PGADEHYDRAT-RXN +xref: Reactome:13384 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004635 +name: phosphoribosyl-AMP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide." [EC:3.5.4.19] +subset: gosubset_prok +synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19] +synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19] +synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19] +xref: EC:3.5.4.19 +xref: MetaCyc:HISTCYCLOHYD-RXN +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0004636 +name: phosphoribosyl-ATP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate." [EC:3.6.1.31] +subset: gosubset_prok +synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31] +synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] +synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31] +xref: EC:3.6.1.31 +xref: MetaCyc:HISTPRATPHYD-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004637 +name: phosphoribosylamine-glycine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide." [EC:6.3.4.13] +subset: gosubset_prok +synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] +synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] +synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] +synonym: "GAR" RELATED [EC:6.3.4.13] +synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] +synonym: "GARS activity" EXACT [EC:6.3.4.13] +synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] +synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] +synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] +synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] +xref: EC:6.3.4.13 +xref: MetaCyc:GLYRIBONUCSYN-RXN +xref: Reactome:13392 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004638 +name: phosphoribosylaminoimidazole carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21] +subset: gosubset_prok +synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] +synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21] +synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21] +synonym: "ADE2" RELATED [EC:4.1.1.21] +synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21] +synonym: "class II PurE" RELATED [EC:4.1.1.21] +xref: EC:4.1.1.21 +xref: MetaCyc:AIRCARBOXY-RXN +xref: Reactome:13396 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004639 +name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate." [EC:6.3.2.6] +subset: gosubset_prok +synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] +synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6] +synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6] +synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] +synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6] +synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] +synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] +synonym: "PurC" RELATED [EC:6.3.2.6] +synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6] +synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6] +synonym: "SAICARs activity" EXACT [EC:6.3.2.6] +xref: EC:6.3.2.6 +xref: MetaCyc:SAICARSYN-RXN +xref: Reactome:13398 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004640 +name: phosphoribosylanthranilate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24] +subset: gosubset_prok +synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] +synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24] +synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24] +synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24] +synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24] +synonym: "PRAI activity" EXACT [EC:5.3.1.24] +xref: EC:5.3.1.24 +xref: MetaCyc:PRAISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004641 +name: phosphoribosylformylglycinamidine cyclo-ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.3.1] +subset: gosubset_prok +synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] +synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] +synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] +synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] +synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] +synonym: "AIRS activity" EXACT [EC:6.3.3.1] +synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] +synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] +xref: EC:6.3.3.1 +xref: MetaCyc:AIRS-RXN +xref: Reactome:13434 +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0004642 +name: phosphoribosylformylglycinamidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate." [EC:6.3.5.3] +subset: gosubset_prok +synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] +synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] +synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3] +synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3] +synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3] +synonym: "FGARAT activity" EXACT [EC:6.3.5.3] +synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3] +synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3] +synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] +synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3] +synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3] +xref: EC:6.3.5.3 +xref: MetaCyc:FGAMSYN-RXN +xref: Reactome:13437 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0004643 +name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] +subset: gosubset_prok +synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] +synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] +synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] +synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] +synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] +synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] +synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] +synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] +synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] +xref: EC:2.1.2.3 +xref: MetaCyc:AICARTRANSFORM-RXN +xref: Reactome:13439 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0004644 +name: phosphoribosylglycinamide formyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] +subset: gosubset_prok +synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2] +synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2] +synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2] +synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] +synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2] +synonym: "GAR TFase activity" EXACT [EC:2.1.2.2] +synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2] +synonym: "GART activity" EXACT [EC:2.1.2.2] +synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] +xref: EC:2.1.2.2 +xref: MetaCyc:GART-RXN +xref: Reactome:13440 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0004645 +name: phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1] +synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1] +synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] +synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] +synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] +synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] +synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] +synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] +synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] +synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] +synonym: "myophosphorylase" NARROW [EC:2.4.1.1] +synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1] +synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] +synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] +xref: EC:2.4.1.1 +xref: MetaCyc:RXN-1826 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0004647 +name: phosphoserine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3] +subset: gosubset_prok +synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] +xref: EC:3.1.3.3 +xref: MetaCyc:PSERPHOSPHA-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004648 +name: phosphoserine transaminase activity +namespace: molecular_function +alt_id: GO:0004646 +def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] +subset: gosubset_prok +synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] +synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] +synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52] +synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52] +synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] +synonym: "O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] +synonym: "PdxC" RELATED [EC:2.6.1.52] +synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52] +synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52] +synonym: "phosphoserine aminotransferase activity" EXACT [] +synonym: "PSAT activity" EXACT [EC:2.6.1.52] +synonym: "SerC" RELATED [EC:2.6.1.52] +xref: EC:2.6.1.52 +xref: MetaCyc:PSERTRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004649 +name: poly(ADP-ribose) glycohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] +xref: EC:3.2.1.143 +xref: MetaCyc:3.2.1.143-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004650 +name: polygalacturonase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] +subset: gosubset_prok +synonym: "endo-D-galacturonase activity" EXACT [] +synonym: "endo-polygalacturonase activity" EXACT [] +synonym: "endogalacturonase activity" EXACT [] +synonym: "endopolygalacturonase activity" EXACT [] +synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] +synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15] +synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15] +synonym: "pectinase activity" NARROW [EC:3.2.1.15] +synonym: "pectolase activity" EXACT [EC:3.2.1.15] +synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] +synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] +xref: EC:3.2.1.15 +xref: MetaCyc:3.2.1.15-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004651 +name: polynucleotide 5'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] +synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] +synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] +synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] +xref: EC:3.1.3.33 +xref: MetaCyc:POLYNUCLEOTIDE-5'-PHOSPHATASE-RXN +xref: Reactome:13463 +is_a: GO:0019204 ! nucleotide phosphatase activity + +[Term] +id: GO:0004652 +name: polynucleotide adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] +subset: gosubset_prok +synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19] +synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] +synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] +synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] +synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] +synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19] +synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19] +synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19] +synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19] +synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19] +synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19] +synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19] +synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19] +synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19] +synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19] +synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19] +synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] +synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] +xref: EC:2.7.7.19 +xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN +xref: Reactome:72182 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004653 +name: polypeptide N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] +synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41] +synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] +synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] +xref: EC:2.4.1.41 +xref: MetaCyc:2.4.1.41-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0004654 +name: polyribonucleotide nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] +subset: gosubset_prok +synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8] +synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8] +synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] +synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] +xref: EC:2.7.7.8 +xref: MetaCyc:2.7.7.8-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004655 +name: porphobilinogen synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O." [EC:4.2.1.24] +subset: gosubset_prok +synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24] +synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24] +synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24] +synonym: "aminolevulinate dehydratase activity" EXACT [] +synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] +synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24] +synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24] +synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] +synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] +xref: EC:4.2.1.24 +xref: MetaCyc:PORPHOBILSYNTH-RXN +xref: Reactome:13469 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004656 +name: procollagen-proline 4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] +synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2] +synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2] +synonym: "peptidyl proline hydroxylase activity" EXACT [EC:1.14.11.2] +synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2] +synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] +synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2] +synonym: "proline, 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.2] +synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] +synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" EXACT [EC:1.14.11.2] +synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2] +synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2] +synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2] +synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2] +synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2] +synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2] +xref: EC:1.14.11.2 +xref: MetaCyc:1.14.11.2-RXN +is_a: GO:0019798 ! procollagen-proline dioxygenase activity +is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity + +[Term] +id: GO:0004657 +name: proline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] +subset: gosubset_prok +synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8] +synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8] +synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8] +xref: EC:1.5.99.8 +xref: MetaCyc:RXN-7181 +xref: Reactome:13472 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0004658 +name: propionyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] +subset: gosubset_prok +synonym: "PCCase activity" EXACT [EC:6.4.1.3] +synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3] +synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3] +xref: EC:6.4.1.3 +xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN +xref: Reactome:13473 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0004659 +name: prenyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] +subset: gosubset_prok +xref: EC:2.5.1.- +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004660 +name: protein farnesyltransferase activity +namespace: molecular_function +alt_id: GO:0018223 +def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] +synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] +synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] +synonym: "FTase activity" EXACT [EC:2.5.1.58] +synonym: "protein-cysteine farnesyltransferase activity" EXACT [] +xref: EC:2.5.1.58 +is_a: GO:0008318 ! protein prenyltransferase activity + +[Term] +id: GO:0004661 +name: protein geranylgeranyltransferase activity +namespace: molecular_function +alt_id: GO:0018224 +def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] +synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] +xref: EC:2.5.1.- +is_a: GO:0008318 ! protein prenyltransferase activity + +[Term] +id: GO:0004662 +name: CAAX-protein geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] +synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] +synonym: "geranylgeranyltransferase type I activity" EXACT [] +synonym: "GGTase-I activity" EXACT [] +synonym: "GGTaseI activity" EXACT [] +synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] +synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] +xref: EC:2.5.1.59 +is_a: GO:0004661 ! protein geranylgeranyltransferase activity + +[Term] +id: GO:0004663 +name: Rab-protein geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] +synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] +synonym: "GGTase-II activity" EXACT [] +synonym: "GGTaseII activity" EXACT [] +synonym: "protein geranylgeranyltransferase type II activity" EXACT [] +synonym: "Rab geranylgeranyltransferase activity" EXACT [] +synonym: "RabGGTase activity" EXACT [] +synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] +xref: EC:2.5.1.60 +is_a: GO:0004661 ! protein geranylgeranyltransferase activity + +[Term] +id: GO:0004664 +name: prephenate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] +subset: gosubset_prok +synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51] +synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51] +xref: EC:4.2.1.51 +xref: MetaCyc:PREPHENATEDEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004665 +name: prephenate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+." [EC:1.3.1.13] +subset: gosubset_prok +synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13] +synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13] +xref: EC:1.3.1.13 +xref: MetaCyc:PREPHENATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004666 +name: prostaglandin-endoperoxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] +synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1] +synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1] +synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] +synonym: "PG synthetase activity" EXACT [EC:1.14.99.1] +synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1] +synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1] +synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1] +synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1] +xref: EC:1.14.99.1 +xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN +xref: Reactome:13496 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004667 +name: prostaglandin-D synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:5.3.99.2] +synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2] +synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2] +synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2] +synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2] +synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2] +synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2] +xref: EC:5.3.99.2 +xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0004668 +name: protein-arginine deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15] +subset: gosubset_prok +synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15] +synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15] +xref: EC:3.5.3.15 +xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004671 +name: protein-S-isoprenylcysteine O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0018225 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] +subset: gosubset_prok +synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] +synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] +xref: EC:2.1.1.100 +xref: MetaCyc:2.1.1.100-RXN +is_a: GO:0003880 ! C-terminal protein carboxyl methyltransferase activity +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004672 +name: protein kinase activity +namespace: molecular_function +alt_id: GO:0050222 +def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] +comment: Note that triphosphate is used as a phosphate donor by at least one kinase. +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +subset: gosubset_prok +synonym: "protamine kinase activity" NARROW [] +xref: MetaCyc:PROTEIN-KINASE-RXN +xref: Reactome:4030 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004673 +name: protein histidine kinase activity +namespace: molecular_function +alt_id: GO:0008896 +def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] +subset: gosubset_prok +synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3] +synonym: "EnvZ" NARROW [EC:2.7.13.3] +synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] +synonym: "histidine kinase activity" EXACT [] +synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3] +synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3] +synonym: "HK1" RELATED [EC:2.7.13.3] +synonym: "HP165" RELATED [EC:2.7.13.3] +synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] +synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3] +synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3] +synonym: "protein-histidine kinase activity" EXACT [] +synonym: "Sln1p" NARROW [EC:2.7.13.3] +xref: EC:2.7.13.3 +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0004674 +name: protein serine/threonine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate." [GOC:bf] +subset: gosubset_prok +synonym: "A-kinase activity" NARROW [EC:2.7.11.1] +synonym: "AP50 kinase activity" NARROW [EC:2.7.11.1] +synonym: "ATP-protein transphosphorylase activity" NARROW [EC:2.7.11.1] +synonym: "ATP:protein phosphotransferase (non-specific) activity" NARROW [EC:2.7.11.1] +synonym: "betaIIPKC" RELATED [EC:2.7.11.1] +synonym: "calcium/phospholipid-dependent protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "casein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] +synonym: "cytidine 3',5'-cyclic monophosphate-responsive protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "dsk1" RELATED [EC:2.7.11.1] +synonym: "epsilon PKC" RELATED [EC:2.7.11.1] +synonym: "glycogen synthase a kinase activity" NARROW [EC:2.7.11.1] +synonym: "glycogen synthase A kinase activity" NARROW [EC:2.7.11.1] +synonym: "glycogen synthase kinase activity" NARROW [EC:2.7.11.1] +synonym: "HIPK2" RELATED [EC:2.7.11.1] +synonym: "Hpr kinase activity" NARROW [EC:2.7.11.1] +synonym: "hydroxyalkyl-protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "M phase-specific cdc2 kinase activity" NARROW [EC:2.7.11.1] +synonym: "MAPK" RELATED [EC:2.7.11.1] +synonym: "mitogen-activated protein kinase activity" BROAD [EC:2.7.11.1] +synonym: "mitogen-activated S6 kinase activity" NARROW [EC:2.7.11.1] +synonym: "non-specific serine/threonine protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "p82 kinase activity" NARROW [EC:2.7.11.1] +synonym: "phosphorylase B kinase kinase activity" NARROW [EC:2.7.11.1] +synonym: "phosphorylase b kinase kinase activity" BROAD [EC:2.7.11.1] +synonym: "PKA" RELATED [EC:2.7.11.1] +synonym: "PKC" RELATED [EC:2.7.11.1] +synonym: "protein glutamyl kinase activity" NARROW [EC:2.7.11.1] +synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] +synonym: "protein kinase A activity" BROAD [EC:2.7.11.1] +synonym: "protein kinase p58 activity" NARROW [EC:2.7.11.1] +synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] +synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] +synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] +synonym: "protein-aspartyl kinase activity" RELATED [EC:2.7.11.1] +synonym: "protein-cysteine kinase activity" NARROW [EC:2.7.11.1] +synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] +synonym: "Prp4 protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "Raf kinase activity" NARROW [EC:2.7.11.1] +synonym: "Raf-1" RELATED [EC:2.7.11.1] +synonym: "ribosomal protein S6 kinase II activity" NARROW [EC:2.7.11.1] +synonym: "ribosomal S6 protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] +synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] +synonym: "STK32" RELATED [EC:2.7.11.1] +synonym: "T-antigen kinase activity" NARROW [EC:2.7.11.1] +synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "twitchin kinase activity" NARROW [EC:2.7.11.1] +synonym: "Wee 1-like kinase activity" NARROW [EC:2.7.11.1] +synonym: "Wee-kinase activity" NARROW [EC:2.7.11.1] +synonym: "WEE1Hu" RELATED [EC:2.7.11.1] +xref: EC:2.7.11 +xref: Reactome:4028 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004675 +name: transmembrane receptor protein serine/threonine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + receptor-protein serine/threonine = ADP + receptor-protein serine/threonine phosphate." [EC:2.7.11.30] +synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30] +synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30] +synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30] +synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30] +synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] +synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] +synonym: "STK13" RELATED [EC:2.7.11.30] +synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30] +xref: EC:2.7.11.- +xref: Reactome:11160 +is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + +[Term] +id: GO:0004676 +name: 3-phosphoinositide-dependent protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide." [GOC:mah] +xref: EC:2.7.11.- +xref: Reactome:13519 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004677 +name: DNA-dependent protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, requiring the presence of DNA." [GOC:mah] +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004679 +name: AMP-activated protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of AMP." [GOC:mah] +synonym: "5'-AMP-activated protein kinase activity" EXACT [] +synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] +xref: EC:2.7.11.- +xref: Reactome:13522 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004680 +name: casein kinase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +xref: EC:2.7.11.- +is_obsolete: true + +[Term] +id: GO:0004681 +name: casein kinase I activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +xref: EC:2.7.11.- +is_obsolete: true + +[Term] +id: GO:0004682 +name: protein kinase CK2 activity +namespace: molecular_function +alt_id: GO:0008604 +def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "casein kinase II activity" RELATED [] +synonym: "casein kinase II, catalytic activity" EXACT [] +synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0004683 +name: calmodulin-dependent protein kinase activity +namespace: molecular_function +alt_id: GO:0004684 +alt_id: GO:0004685 +alt_id: GO:0004688 +def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] +subset: gosubset_prok +synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] +synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] +synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] +synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] +synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] +synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] +synonym: "calmodulin regulated protein kinase activity" EXACT [] +synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] +synonym: "calmodulin-dependent protein kinase I activity" NARROW [] +synonym: "CaM kinase activity" EXACT [EC:2.7.11.17] +synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] +synonym: "CAM PKII" RELATED [EC:2.7.11.17] +synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17] +synonym: "CaMKI" RELATED [EC:2.7.11.17] +synonym: "CaMKII" RELATED [EC:2.7.11.17] +synonym: "CaMKIV" RELATED [EC:2.7.11.17] +synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] +synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] +synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] +synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] +synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] +synonym: "STK20" RELATED [EC:2.7.11.17] +xref: EC:2.7.11.17 +xref: MetaCyc:2.7.11.17-RXN +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004686 +name: elongation factor-2 kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of eukaryotic elongation factor-2." [GOC:jl, PMID:11904175] +synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20] +synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20] +synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20] +synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20] +synonym: "eEF-2 kinase activity" EXACT [] +synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20] +synonym: "eEF2K" RELATED [EC:2.7.11.20] +synonym: "EF2K" RELATED [EC:2.7.11.20] +synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] +synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] +synonym: "STK19" RELATED [EC:2.7.11.20] +xref: EC:2.7.11.20 +is_a: GO:0004683 ! calmodulin-dependent protein kinase activity + +[Term] +id: GO:0004687 +name: myosin light chain kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (myosin-light-chain) = ADP + (myosin-light-chain) phosphate." [EC:2.7.11.18] +synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] +synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18] +synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18] +synonym: "MLCK" RELATED [EC:2.7.11.18] +synonym: "MLCkase activity" EXACT [EC:2.7.11.18] +synonym: "myosin kinase activity" EXACT [EC:2.7.11.18] +synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18] +synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] +synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18] +synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18] +synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18] +synonym: "myosin-light-chain kinase activity" EXACT [] +synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] +synonym: "STK18" RELATED [EC:2.7.11.18] +xref: EC:2.7.11.18 +xref: MetaCyc:MYOSIN-LIGHT-CHAIN-KINASE-RXN +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004689 +name: phosphorylase kinase activity +namespace: molecular_function +alt_id: GO:0008606 +def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] +subset: gosubset_prok +synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19] +synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19] +synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19] +synonym: "PHK" RELATED [EC:2.7.11.19] +synonym: "phosphorylase b kinase activity" EXACT [EC:2.7.11.19] +synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19] +synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19] +synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] +synonym: "STK17" RELATED [EC:2.7.11.19] +xref: EC:2.7.11.19 +xref: MetaCyc:PHOSPHORYLASE-KINASE-RXN +xref: Reactome:13545 +is_a: GO:0004683 ! calmodulin-dependent protein kinase activity + +[Term] +id: GO:0004690 +name: cyclic nucleotide-dependent protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide." [GOC:mah] +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004691 +name: cAMP-dependent protein kinase activity +namespace: molecular_function +alt_id: GO:0008602 +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP." [EC:2.7.11.11] +synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] +synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] +synonym: "AMPK" RELATED [EC:2.7.11.11] +synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] +synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] +synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] +synonym: "PKA" RELATED [EC:2.7.11.11] +synonym: "PKA C" RELATED [EC:2.7.11.11] +synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] +synonym: "STK22" RELATED [EC:2.7.11.11] +xref: EC:2.7.11.11 +xref: Reactome:13562 +is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity + +[Term] +id: GO:0004692 +name: cGMP-dependent protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cGMP." [GOC:mah] +synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12] +synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12] +synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12] +synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12] +synonym: "PKG" RELATED [EC:2.7.11.12] +synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] +synonym: "PKG 1beta" RELATED [EC:2.7.11.12] +synonym: "PKG II" RELATED [EC:2.7.11.12] +synonym: "STK23" RELATED [EC:2.7.11.12] +xref: EC:2.7.11.12 +is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity + +[Term] +id: GO:0004693 +name: cyclin-dependent protein kinase activity +namespace: molecular_function +alt_id: GO:0016537 +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670] +synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22] +synonym: "Bur1" RELATED [EC:2.7.11.22] +synonym: "Bur1 Cdk" RELATED [EC:2.7.11.22] +synonym: "Cak1" RELATED [EC:2.7.11.22] +synonym: "Cak1p" RELATED [EC:2.7.11.22] +synonym: "cdc2" RELATED [EC:2.7.11.22] +synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] +synonym: "Cdc28p" RELATED [EC:2.7.11.22] +synonym: "CDK" RELATED [EC:2.7.11.22] +synonym: "CDK activity" EXACT [] +synonym: "CDK, catalytic subunit activity" EXACT [] +synonym: "cdk-activating kinase activity" EXACT [EC:2.7.11.22] +synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22] +synonym: "cdk1" RELATED [EC:2.7.11.22] +synonym: "cdk2" RELATED [EC:2.7.11.22] +synonym: "Cdk2" RELATED [EC:2.7.11.22] +synonym: "cdk3" RELATED [EC:2.7.11.22] +synonym: "cdk4" RELATED [EC:2.7.11.22] +synonym: "cdk5" RELATED [EC:2.7.11.22] +synonym: "cdk6" RELATED [EC:2.7.11.22] +synonym: "cdk7" RELATED [EC:2.7.11.22] +synonym: "cdk8" RELATED [EC:2.7.11.22] +synonym: "cdk9" RELATED [EC:2.7.11.22] +synonym: "cyclin A-activated cdc2" RELATED [EC:2.7.11.22] +synonym: "cyclin A-activated cdk2" RELATED [EC:2.7.11.22] +synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] +synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] +synonym: "cyk" RELATED [EC:2.7.11.22] +synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] +synonym: "nclk" RELATED [EC:2.7.11.22] +synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] +synonym: "PCTAIRE-1" RELATED [EC:2.7.11.22] +synonym: "STK25" RELATED [EC:2.7.11.22] +xref: EC:2.7.11.22 +xref: Reactome:13565 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004694 +name: eukaryotic translation initiation factor 2alpha kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (EIF2)." [GOC:mah, InterPro:IPR015516] +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004695 +name: galactosyltransferase-associated kinase activity +namespace: molecular_function +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004696 +name: glycogen synthase kinase 3 activity +namespace: molecular_function +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004697 +name: protein kinase C activity +namespace: molecular_function +alt_id: GO:0004701 +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol." [EC:2.7.11.13] +synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13] +synonym: "cPKC" RELATED [EC:2.7.11.13] +synonym: "cPKCalpha" RELATED [EC:2.7.11.13] +synonym: "cPKCbeta" RELATED [EC:2.7.11.13] +synonym: "cPKCgamma" RELATED [EC:2.7.11.13] +synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] +synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] +synonym: "nPKC" RELATED [EC:2.7.11.13] +synonym: "nPKCdelta" RELATED [EC:2.7.11.13] +synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] +synonym: "nPKCeta" RELATED [EC:2.7.11.13] +synonym: "nPKCtheta" RELATED [EC:2.7.11.13] +synonym: "PKC" RELATED [EC:2.7.11.13] +synonym: "PKC activity" EXACT [] +synonym: "Pkc1p" RELATED [EC:2.7.11.13] +synonym: "PKCalpha" RELATED [EC:2.7.11.13] +synonym: "PKCbeta" RELATED [EC:2.7.11.13] +synonym: "PKCdelta" RELATED [EC:2.7.11.13] +synonym: "PKCepsilon" RELATED [EC:2.7.11.13] +synonym: "PKCgamma" RELATED [EC:2.7.11.13] +synonym: "PKCzeta" RELATED [EC:2.7.11.13] +synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] +synonym: "STK24" RELATED [EC:2.7.11.13] +xref: EC:2.7.11.13 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004698 +name: calcium-dependent protein kinase C activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah] +synonym: "calcium-dependent PKC activity" EXACT [] +xref: EC:2.7.11.- +xref: Reactome:13572 +is_a: GO:0004697 ! protein kinase C activity + +[Term] +id: GO:0004699 +name: calcium-independent protein kinase C activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] +synonym: "calcium-independent PKC activity" EXACT [] +is_a: GO:0004697 ! protein kinase C activity + +[Term] +id: GO:0004700 +name: atypical protein kinase C activity +namespace: molecular_function +synonym: "atypical PKC activity" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004697 ! protein kinase C activity + +[Term] +id: GO:0004702 +name: receptor signaling protein serine/threonine kinase activity +namespace: molecular_function +synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0004703 +name: G-protein coupled receptor kinase activity +namespace: molecular_function +alt_id: GO:0004678 +def: "Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity." [GOC:dph] +synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16] +synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] +synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] +synonym: "G-protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] +synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] +synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16] +synonym: "GPCR phosphorylating protein kinase activity" EXACT [] +synonym: "GPCRK" RELATED [EC:2.7.11.16] +synonym: "GRK4" RELATED [EC:2.7.11.16] +synonym: "GRK5" RELATED [EC:2.7.11.16] +synonym: "GRK6" RELATED [EC:2.7.11.16] +synonym: "STK16" RELATED [EC:2.7.11.16] +xref: EC:2.7.11.16 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004704 +name: NF-kappaB-inducing kinase activity +namespace: molecular_function +synonym: "NIK" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity + +[Term] +id: GO:0004705 +name: JUN kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "c-Jun N-terminal kinase activity" NARROW [] +synonym: "JNK" EXACT [] +synonym: "JNK3alpha1" RELATED [] +synonym: "SAPK1" NARROW [] +xref: EC:2.7.11.- +is_a: GO:0016909 ! SAP kinase activity + +[Term] +id: GO:0004706 +name: JUN kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] +synonym: "JNK kinase kinase activity" RELATED [] +synonym: "JNKKK" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004709 ! MAP kinase kinase kinase activity + +[Term] +id: GO:0004707 +name: MAP kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] +synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24] +synonym: "Dp38" RELATED [EC:2.7.11.24] +synonym: "ERK" RELATED [EC:2.7.11.24] +synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] +synonym: "LeMPK3" RELATED [EC:2.7.11.24] +synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24] +synonym: "MAPK" RELATED [EC:2.7.11.24] +synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] +synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] +synonym: "mitogen activated kinase activity" EXACT [] +synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24] +synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] +synonym: "p38-2" RELATED [EC:2.7.11.24] +synonym: "p38delta" RELATED [EC:2.7.11.24] +synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24] +synonym: "p42mapk" RELATED [EC:2.7.11.24] +synonym: "p44mpk" RELATED [EC:2.7.11.24] +synonym: "PMK-1" RELATED [EC:2.7.11.24] +synonym: "PMK-2" RELATED [EC:2.7.11.24] +synonym: "PMK-3" RELATED [EC:2.7.11.24] +synonym: "pp42" RELATED [EC:2.7.11.24] +synonym: "pp44mapk" RELATED [EC:2.7.11.24] +synonym: "STK26" RELATED [EC:2.7.11.24] +xref: EC:2.7.11.24 +xref: Reactome:4049 +is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity + +[Term] +id: GO:0004708 +name: MAP kinase kinase activity +namespace: molecular_function +def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase." [ISBN:0198547684] +synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2] +synonym: "ERK activator kinase activity" EXACT [] +synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] +synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] +synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] +synonym: "MAP2K" RELATED [EC:2.7.12.2] +synonym: "MAPKK" RELATED [EC:2.7.12.2] +synonym: "MAPKK activity" EXACT [] +synonym: "MAPKK1" RELATED [EC:2.7.12.2] +synonym: "MEK activity" BROAD [] +synonym: "MEK1" RELATED [EC:2.7.12.2] +synonym: "MEK2" RELATED [EC:2.7.12.2] +synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2] +synonym: "MKK" RELATED [EC:2.7.12.2] +synonym: "MKK2" RELATED [EC:2.7.12.2] +synonym: "MKK4" RELATED [EC:2.7.12.2] +synonym: "MKK6" RELATED [EC:2.7.12.2] +synonym: "MKK7" RELATED [EC:2.7.12.2] +synonym: "STK27" RELATED [EC:2.7.12.2] +xref: EC:2.7.11.- +is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity + +[Term] +id: GO:0004709 +name: MAP kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] +synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25] +synonym: "cMos" RELATED [EC:2.7.11.25] +synonym: "cRaf" RELATED [EC:2.7.11.25] +synonym: "MAP3K" RELATED [EC:2.7.11.25] +synonym: "MAPKKK activity" EXACT [EC:2.7.11.25] +synonym: "MEK kinase activity" EXACT [EC:2.7.11.25] +synonym: "MEKK" RELATED [EC:2.7.11.25] +synonym: "MEKK1" RELATED [EC:2.7.11.25] +synonym: "MEKK2" RELATED [EC:2.7.11.25] +synonym: "MEKK3" RELATED [EC:2.7.11.25] +synonym: "Mil/Raf" RELATED [EC:2.7.11.25] +synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25] +synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] +synonym: "MLTK" RELATED [EC:2.7.11.25] +synonym: "MLTKa" RELATED [EC:2.7.11.25] +synonym: "MLTKb" RELATED [EC:2.7.11.25] +synonym: "REKS" RELATED [EC:2.7.11.25] +synonym: "STK28" RELATED [EC:2.7.11.25] +xref: EC:2.7.11.25 +is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity + +[Term] +id: GO:0004710 +name: MAP/ERK kinase kinase activity +namespace: molecular_function +synonym: "MEKK activity" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004709 ! MAP kinase kinase kinase activity + +[Term] +id: GO:0004711 +name: ribosomal protein S6 kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of ribosomal protein S6." [GOC:mah, PMID:9822608] +xref: EC:2.7.11.- +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004712 +name: protein serine/threonine/tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein serine/threonine/tyrosine = ADP + protein serine/threonine/tyrosine phosphate." [GOC:mah] +subset: gosubset_prok +synonym: "ADK1" RELATED [EC:2.7.12.1] +synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1] +synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1] +synonym: "CLK1" RELATED [EC:2.7.12.1] +synonym: "dDYRK2" RELATED [EC:2.7.12.1] +synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1] +synonym: "dual-specificity protein kinase" BROAD [] +synonym: "Mps1p" RELATED [EC:2.7.12.1] +synonym: "protein threonine/tyrosine kinase activity" NARROW [] +xref: EC:2.7.112.1 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004713 +name: protein tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] +subset: gosubset_prok +synonym: "protein-tyrosine kinase activity" EXACT [] +xref: EC:2.7.10 +xref: MetaCyc:PROTEIN-TYROSINE-KINASE-RXN +xref: Reactome:11065 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004714 +name: transmembrane receptor protein tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity." [EC:2.7.10.1, GOC:mah] +subset: gosubset_prok +synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1] +synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1] +synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1] +synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1] +synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1] +synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1] +synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1] +synonym: "neurotrophin TRK receptor activity" RELATED [] +synonym: "neurotrophin TRKA receptor activity" RELATED [] +synonym: "neurotrophin TRKB receptor activity" RELATED [] +synonym: "neurotrophin TRKC receptor activity" RELATED [] +synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1] +synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1] +synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1] +synonym: "sevenless receptor activity" RELATED [] +xref: EC:2.7.10.1 +xref: Reactome:11064 +is_a: GO:0004713 ! protein tyrosine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + +[Term] +id: GO:0004715 +name: non-membrane spanning protein tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] +synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2] +synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] +synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] +synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] +synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] +synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] +synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] +synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] +synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2] +synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] +xref: EC:2.7.10.2 +is_a: GO:0004713 ! protein tyrosine kinase activity + +[Term] +id: GO:0004716 +name: receptor signaling protein tyrosine kinase activity +namespace: molecular_function +synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] +xref: EC:2.7.10.- +is_a: GO:0004713 ! protein tyrosine kinase activity +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0004717 +name: focal adhesion kinase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic] +comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. +synonym: "FAK" EXACT [] +is_obsolete: true +replaced_by: GO:0004713 + +[Term] +id: GO:0004718 +name: Janus kinase activity +namespace: molecular_function +synonym: "JAK" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004716 ! receptor signaling protein tyrosine kinase activity + +[Term] +id: GO:0004719 +name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] +subset: gosubset_prok +synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77] +synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77] +synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] +xref: EC:2.1.1.77 +xref: MetaCyc:2.1.1.77-RXN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004720 +name: protein-lysine 6-oxidase activity +namespace: molecular_function +alt_id: GO:0018056 +def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2." [EC:1.4.3.13] +synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13] +synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13] +xref: EC:1.4.3.13 +xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0004721 +name: phosphoprotein phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +subset: gosubset_prok +synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] +synonym: "protein phosphatase activity" EXACT [] +synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] +xref: EC:3.1.3.16 +xref: MetaCyc:3.1.3.16-RXN +xref: Reactome:1887 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004722 +name: protein serine/threonine phosphatase activity +namespace: molecular_function +alt_id: GO:0000158 +alt_id: GO:0000163 +alt_id: GO:0008598 +alt_id: GO:0008600 +alt_id: GO:0015071 +alt_id: GO:0030357 +alt_id: GO:0030358 +alt_id: GO:0030360 +alt_id: GO:0030361 +def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:bf] +subset: gosubset_prok +synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] +synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] +synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] +synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] +synonym: "calcineurin" NARROW [] +synonym: "casein phosphatase" NARROW [EC:3.1.3.16] +synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] +synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] +synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] +synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] +synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] +synonym: "phosphatase I" NARROW [EC:3.1.3.16] +synonym: "phosphatase IB" NARROW [EC:3.1.3.16] +synonym: "phosphatase II" NARROW [EC:3.1.3.16] +synonym: "phosphatase III" NARROW [EC:3.1.3.16] +synonym: "phosphatase IV" NARROW [EC:3.1.3.16] +synonym: "phosphatase SP" NARROW [EC:3.1.3.16] +synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] +synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] +synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] +synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase type 1 activity" NARROW [] +synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] +synonym: "protein phosphatase type 2A activity" NARROW [] +synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] +synonym: "protein phosphatase type 2B activity" NARROW [] +synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] +synonym: "protein phosphatase type 2C activity" NARROW [] +synonym: "protein phosphatase type 4 activity" NARROW [] +synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] +synonym: "protein phosphatase X" NARROW [] +synonym: "serine/threonine specific protein phosphatase activity" EXACT [] +xref: Reactome:21718 +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0004723 +name: calcium-dependent protein serine/threonine phosphatase activity +namespace: molecular_function +alt_id: GO:0008596 +def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions." [EC:3.1.3.16, GOC:mah] +synonym: "calcineurin" NARROW [] +synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0004724 +name: magnesium-dependent protein serine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of a serine- or threonine-bound phosphate group from a protein; action dependent on magnesium." [EC:3.1.3.16] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0004725 +name: protein tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] +subset: gosubset_prok +synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48] +synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48] +synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "PTPase activity" EXACT [EC:3.1.3.48] +synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48] +synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] +xref: EC:3.1.3.48 +xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN +xref: Reactome:11061 +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0004726 +name: non-membrane spanning protein tyrosine phosphatase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0004727 +name: prenylated protein tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0004728 +name: receptor signaling protein tyrosine phosphatase activity +namespace: molecular_function +synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] +is_a: GO:0004725 ! protein tyrosine phosphatase activity +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0004729 +name: protoporphyrinogen oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2." [EC:1.3.3.4] +subset: gosubset_prok +synonym: "protoporphyrinogen IX oxidase activity" EXACT [EC:1.3.3.4] +synonym: "protoporphyrinogen-IX oxidase activity" EXACT [EC:1.3.3.4] +synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4] +synonym: "protoporphyrinogenase activity" EXACT [EC:1.3.3.4] +xref: EC:1.3.3.4 +xref: MetaCyc:PROTOPORGENOXI-RXN +xref: Reactome:14184 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0004730 +name: pseudouridylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O." [EC:4.2.1.70] +comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. +subset: gosubset_prok +synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70] +synonym: "pseudouridine monophosphate synthase activity" EXACT [] +synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70] +synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70] +synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70] +synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70] +synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70] +synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70] +synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] +xref: EC:4.2.1.70 +xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004731 +name: purine-nucleoside phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] +subset: gosubset_prok +synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] +synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1] +synonym: "PNPase activity" EXACT [EC:2.4.2.1] +synonym: "PUNPI" RELATED [EC:2.4.2.1] +synonym: "PUNPII" RELATED [EC:2.4.2.1] +synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1] +synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] +synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1] +synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] +synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1] +xref: EC:2.4.2.1 +xref: MetaCyc:PNP-RXN +xref: Reactome:14201 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004732 +name: pyridoxal oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + H2O2." [EC:1.2.3.8] +synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8] +xref: EC:1.2.3.8 +xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0004733 +name: pyridoxamine-phosphate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2." [EC:1.4.3.5] +subset: gosubset_prok +synonym: "PdxH" RELATED [EC:1.4.3.5] +synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] +synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] +synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] +synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] +synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] +synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] +synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] +synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] +synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] +xref: EC:1.4.3.5 +xref: MetaCyc:PMPOXI-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0004734 +name: pyrimidodiazepine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] +synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] +synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] +xref: EC:1.5.4.1 +xref: MetaCyc:1.5.4.1-RXN +is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor + +[Term] +id: GO:0004735 +name: pyrroline-5-carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] +subset: gosubset_prok +synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2] +synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2] +synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] +synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] +synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2] +synonym: "P5CR activity" EXACT [EC:1.5.1.2] +xref: EC:1.5.1.2 +xref: MetaCyc:PYRROLINECARBREDUCT-RXN +xref: Reactome:14208 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004736 +name: pyruvate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate." [EC:6.4.1.1] +subset: gosubset_prok +synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1] +synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1] +xref: EC:6.4.1.1 +xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN +xref: Reactome:14209 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0004737 +name: pyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] +subset: gosubset_prok +synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1] +synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1] +synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1] +synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1] +synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1] +xref: EC:4.1.1.1 +xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004738 +name: pyruvate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094] +subset: gosubset_prok +synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] +synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0004739 +name: pyruvate dehydrogenase (acetyl-transferring) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] +subset: gosubset_prok +synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] +synonym: "PDH" RELATED [EC:1.2.4.1] +synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] +synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] +synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] +synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] +xref: EC:1.2.4.1 +xref: MetaCyc:PYRUVATEDECARB-RXN +xref: Reactome:14213 +is_a: GO:0004738 ! pyruvate dehydrogenase activity +is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + +[Term] +id: GO:0004740 +name: pyruvate dehydrogenase (acetyl-transferring) kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] +synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT [] +synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2] +synonym: "PDH kinase activity" EXACT [EC:2.7.11.2] +synonym: "PDHK" RELATED [EC:2.7.11.2] +synonym: "PDK" RELATED [EC:2.7.11.2] +synonym: "PDK1" RELATED [EC:2.7.11.2] +synonym: "PDK2" RELATED [EC:2.7.11.2] +synonym: "PDK3" RELATED [EC:2.7.11.2] +synonym: "PDK4" RELATED [EC:2.7.11.2] +synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT [] +synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2] +synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2] +synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2] +synonym: "STK1" RELATED [EC:2.7.11.2] +xref: EC:2.7.11.2 +xref: MetaCyc:2.7.11.2-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004741 +name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity +namespace: molecular_function +alt_id: GO:0019906 +def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] +synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] +synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] +synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] +synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43] +synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43] +synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] +xref: EC:3.1.3.43 +xref: MetaCyc:3.1.3.43-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004742 +name: dihydrolipoyllysine-residue acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] +subset: gosubset_prok +synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] +synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12] +synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12] +synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12] +synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12] +synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] +synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] +xref: EC:2.3.1.12 +xref: MetaCyc:DIHYDLIPACETRANS-RXN +xref: Reactome:14238 +is_a: GO:0016418 ! S-acetyltransferase activity +is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity + +[Term] +id: GO:0004743 +name: pyruvate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] +subset: gosubset_prok +synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40] +synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] +synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] +xref: EC:2.7.1.40 +xref: MetaCyc:PEPDEPHOS-RXN +xref: Reactome:14240 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004744 +name: retinal isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [EC:5.2.1.3] +synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3] +synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] +synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] +xref: EC:5.2.1.3 +xref: MetaCyc:RETINAL-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0004745 +name: retinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] +subset: gosubset_prok +synonym: "all-trans retinol dehydrogenase activity" EXACT [EC:1.1.1.105] +synonym: "MDR" RELATED [EC:1.1.1.105] +synonym: "microsomal retinol dehydrogenase activity" EXACT [EC:1.1.1.105] +synonym: "retinene reductase activity" EXACT [EC:1.1.1.105] +synonym: "retinol (vitamin A1) dehydrogenase activity" EXACT [EC:1.1.1.105] +synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105] +xref: EC:1.1.1.105 +xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004746 +name: riboflavin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine." [EC:2.5.1.9] +subset: gosubset_prok +synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9] +synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] +synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] +synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] +synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9] +synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9] +synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9] +synonym: "vitamin B2 synthase activity" EXACT [] +xref: EC:2.5.1.9 +xref: MetaCyc:RIBOFLAVIN-SYN-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004747 +name: ribokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] +subset: gosubset_prok +synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15] +synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15] +synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15] +synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15] +xref: EC:2.7.1.15 +xref: MetaCyc:RIBOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004748 +name: ribonucleoside-diphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] +subset: gosubset_prok +synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] +synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] +synonym: "nucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] +synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED [] +synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [EC:1.17.4.1] +synonym: "ribonucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] +synonym: "ribonucleotide diphosphate reductase activity" EXACT [EC:1.17.4.1] +synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.1] +synonym: "RNR" EXACT [] +xref: EC:1.17.4.1 +xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN +is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor + +[Term] +id: GO:0004749 +name: ribose phosphate diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.6.1] +subset: gosubset_prok +synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1] +synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1] +synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1] +synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1] +synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1] +synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1] +synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1] +synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] +synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] +synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1] +synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] +xref: EC:2.7.6.1 +xref: MetaCyc:PRPPSYN-RXN +xref: MetaCyc:PWY0-662 +xref: Reactome:14245 +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0004750 +name: ribulose-phosphate 3-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1] +subset: gosubset_prok +synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1] +synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1] +synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1] +synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1] +synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1] +synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1] +synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] +synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] +xref: EC:5.1.3.1 +xref: MetaCyc:RIBULP3EPIM-RXN +xref: Reactome:14262 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0004751 +name: ribose-5-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6] +subset: gosubset_prok +synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] +synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] +synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] +synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] +synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] +synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] +synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] +synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] +synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] +xref: EC:5.3.1.6 +xref: MetaCyc:RIB5PISOM-RXN +xref: Reactome:14263 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004753 +name: saccharopine dehydrogenase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] +synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] +xref: EC:1.5.1.- +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004754 +name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+." [EC:1.5.1.7] +subset: gosubset_prok +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] +synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7] +synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7] +synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] +xref: EC:1.5.1.7 +xref: MetaCyc:1.5.1.7-RXN +xref: Reactome:70922 +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0004755 +name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+." [EC:1.5.1.10] +subset: gosubset_prok +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] +synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] +synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] +synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10] +synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] +synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10] +synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10] +xref: EC:1.5.1.10 +xref: MetaCyc:1.5.1.10-RXN +xref: Reactome:70935 +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0004756 +name: selenide, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + selenide + H2O = AMP + selenophosphate + phosphate." [EC:2.7.9.3] +subset: gosubset_prok +synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3] +synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3] +synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3] +synonym: "selenophosphate synthase activity" EXACT [] +synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3] +xref: EC:2.7.9.3 +xref: MetaCyc:2.7.9.3-RXN +xref: UM-BBD_enzymeID:e0509 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0004757 +name: sepiapterin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] +subset: gosubset_prok +synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153] +xref: EC:1.1.1.153 +xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004758 +name: serine C-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2." [EC:2.3.1.50] +synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50] +synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] +synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50] +synonym: "serine palmitoyltransferase" BROAD [] +synonym: "SPT" RELATED [EC:2.3.1.50] +xref: EC:2.3.1.50 +xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN +is_a: GO:0016454 ! C-palmitoyltransferase activity + +[Term] +id: GO:0004760 +name: serine-pyruvate transaminase activity +namespace: molecular_function +alt_id: GO:0004761 +alt_id: GO:0004762 +alt_id: GO:0004763 +def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51] +subset: gosubset_prok +synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51] +synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] +synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] +synonym: "serine-pyruvate aminotransferase activity" EXACT [] +synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] +synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] +synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] +synonym: "SPT" RELATED [EC:2.6.1.51] +xref: EC:2.6.1.51 +xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004764 +name: shikimate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] +subset: gosubset_prok +synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] +synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] +synonym: "dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] +synonym: "DHS reductase activity" EXACT [EC:1.1.1.25] +synonym: "shikimate oxidoreductase activity" EXACT [EC:1.1.1.25] +synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25] +synonym: "shikimate:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.25] +xref: EC:1.1.1.25 +xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004765 +name: shikimate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate." [EC:2.7.1.71] +subset: gosubset_prok +synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71] +synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71] +synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] +xref: EC:2.7.1.71 +xref: MetaCyc:SHIKIMATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004766 +name: spermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] +subset: gosubset_prok +synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16] +synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16] +synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16] +synonym: "SpeE" RELATED [EC:2.5.1.16] +synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16] +xref: EC:2.5.1.16 +xref: MetaCyc:SPERMIDINESYN-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004767 +name: sphingomyelin phosphodiesterase activity +namespace: molecular_function +alt_id: GO:0030230 +alt_id: GO:0030231 +def: "Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate." [EC:3.1.4.12] +subset: gosubset_prok +synonym: "acid sphingomyelin phosphodiesterase" NARROW [] +synonym: "acid sphingomyelinase activity" NARROW [EC:3.1.4.12] +synonym: "neutral sphingomyelin phosphodiesterase" NARROW [] +synonym: "neutral sphingomyelinase activity" NARROW [EC:3.1.4.12] +synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] +synonym: "sphingomyelinase activity" EXACT [] +xref: EC:3.1.4.12 +xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004768 +name: stearoyl-CoA 9-desaturase activity +namespace: molecular_function +alt_id: GO:0016214 +def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] +comment: Note that this function was formerly EC:1.14.99.5. +subset: gosubset_prok +synonym: "acyl-CoA desaturase activity" EXACT [EC:1.14.19.1] +synonym: "delta(9)-desaturase activity" EXACT [EC:1.14.19.1] +synonym: "delta9-desaturase activity" EXACT [EC:1.14.19.1] +synonym: "fatty acid desaturase activity" EXACT [EC:1.14.19.1] +synonym: "stearoyl-CoA desaturase activity" EXACT [] +synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1] +synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1] +xref: EC:1.14.19.1 +xref: MetaCyc:1.14.19.1-RXN +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0004769 +name: steroid delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] +subset: gosubset_prok +synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1] +synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1] +synonym: "steroid D-isomerase activity" EXACT [] +synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1] +xref: EC:5.3.3.1 +xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004770 +name: sterol carrier protein X-related thiolase activity +namespace: molecular_function +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0004771 +name: sterol esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] +synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] +synonym: "cholesterase activity" EXACT [EC:3.1.1.13] +synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] +synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] +synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] +synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] +synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] +synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] +synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] +synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] +synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] +xref: EC:3.1.1.13 +xref: MetaCyc:STEROL-ESTERASE-RXN +xref: Reactome:14316 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0004772 +name: sterol O-acyltransferase activity +namespace: molecular_function +alt_id: GO:0017066 +def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah] +synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26] +synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004773 +name: steryl-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + SO4(2-) (sulfate)." [EC:3.1.6.2] +synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2] +synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] +synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2] +synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] +synonym: "steryl-sulphatase activity" EXACT [] +xref: EC:3.1.6.2 +xref: MetaCyc:STERYL-SULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004774 +name: succinate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction between succinate and CoA to form succinyl-CoA." [EC:6.2.1.-, GOC:ai] +subset: gosubset_prok +xref: EC:6.2.1.- +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0004775 +name: succinate-CoA ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] +subset: gosubset_prok +synonym: "A-SCS" RELATED [EC:6.2.1.5] +synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5] +synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5] +synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5] +synonym: "succinic thiokinase" BROAD [EC:6.2.1.5] +synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5] +synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5] +synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5] +synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5] +xref: EC:6.2.1.5 +xref: MetaCyc:SUCCCOASYN-RXN +xref: Reactome:14321 +is_a: GO:0004774 ! succinate-CoA ligase activity + +[Term] +id: GO:0004776 +name: succinate-CoA ligase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] +subset: gosubset_prok +synonym: "G-STK" RELATED [EC:6.2.1.4] +synonym: "P-enzyme" RELATED [EC:6.2.1.4] +synonym: "SCS" RELATED [EC:6.2.1.4] +synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4] +synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4] +synonym: "succinic thiokinase" BROAD [EC:6.2.1.4] +synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4] +synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4] +synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] +synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4] +synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] +xref: EC:6.2.1.4 +xref: MetaCyc:SUCCINATE--COA-LIGASE-(GDP-FORMING)-RXN +xref: Reactome:14322 +is_a: GO:0004774 ! succinate-CoA ligase activity + +[Term] +id: GO:0004777 +name: succinate-semialdehyde dehydrogenase activity +namespace: molecular_function +alt_id: GO:0008952 +def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] +subset: gosubset_prok +synonym: "succinate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] +synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] +synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] +synonym: "succinic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] +synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] +xref: EC:1.2.1.24 +xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004778 +name: succinyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + H2O = CoA + succinate." [EC:3.1.2.3] +synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3] +synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3] +synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3] +xref: EC:3.1.2.3 +xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0004779 +name: sulfate adenylyltransferase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "sulphate adenylyltransferase activity" EXACT [] +xref: EC:2.7.7.- +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004780 +name: sulfate adenylyltransferase (ADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + SO4(2-) (sulfate) = phosphate + adenylylsulfate." [EC:2.7.7.5] +synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5] +synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5] +synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] +synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5] +synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] +xref: EC:2.7.7.5 +xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-(ADP)-RXN +is_a: GO:0004779 ! sulfate adenylyltransferase activity + +[Term] +id: GO:0004781 +name: sulfate adenylyltransferase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + SO4(2-) (sulfate) = diphosphate + adenylylsulfate." [EC:2.7.7.4] +subset: gosubset_prok +synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4] +synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4] +synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4] +synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4] +synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4] +synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] +synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4] +synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] +synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] +xref: EC:2.7.7.4 +xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN +xref: Reactome:14341 +is_a: GO:0004779 ! sulfate adenylyltransferase activity + +[Term] +id: GO:0004782 +name: sulfinoalanine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] +synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29] +synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29] +synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29] +synonym: "CSAD" RELATED [EC:4.1.1.29] +synonym: "CSADCase activity" EXACT [EC:4.1.1.29] +synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29] +synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29] +synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29] +synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] +synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] +synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] +synonym: "sulphinoalanine decarboxylase activity" EXACT [] +xref: EC:4.1.1.29 +xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004783 +name: sulfite reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: H2S + 3 NADP+ + 3 H2O = SO3(2-) (sulfite) + 3 NADPH + 3 H+." [EC:1.8.1.2] +subset: gosubset_prok +synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2] +synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2] +synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2] +synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2] +synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] +synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2] +synonym: "sulphite reductase (NADPH) activity" EXACT [] +xref: EC:1.8.1.2 +xref: MetaCyc:SULFITE-REDUCT-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004784 +name: superoxide dismutase activity +namespace: molecular_function +alt_id: GO:0004785 +alt_id: GO:0008382 +alt_id: GO:0008383 +alt_id: GO:0016954 +def: "Catalysis of the reaction: 2 peroxide radical + 2 H+ = O2 + H2O2." [EC:1.15.1.1] +subset: gosubset_prok +synonym: "copper, zinc superoxide dismutase activity" NARROW [] +synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] +synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] +synonym: "cuprein" RELATED [EC:1.15.1.1] +synonym: "cytocuprein" RELATED [EC:1.15.1.1] +synonym: "erythrocuprein" RELATED [EC:1.15.1.1] +synonym: "Fe-SOD" RELATED [EC:1.15.1.1] +synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] +synonym: "hemocuprein" RELATED [EC:1.15.1.1] +synonym: "hepatocuprein" RELATED [EC:1.15.1.1] +synonym: "iron superoxide dismutase activity" NARROW [] +synonym: "iron superoxide oxidoreductase" RELATED [] +synonym: "manganese superoxide dismutase activity" NARROW [] +synonym: "manganese superoxide oxidoreductase" RELATED [] +synonym: "Mn, Fe superoxide dismutase" NARROW [] +synonym: "Mn-SOD" RELATED [EC:1.15.1.1] +synonym: "nickel superoxide dismutase activity" NARROW [] +synonym: "nickel superoxide oxidoreductase" RELATED [] +synonym: "SOD" RELATED [EC:1.15.1.1] +synonym: "SOD-1" RELATED [EC:1.15.1.1] +synonym: "SOD-2" RELATED [EC:1.15.1.1] +synonym: "SOD-3" RELATED [EC:1.15.1.1] +synonym: "SOD-4" RELATED [EC:1.15.1.1] +synonym: "SODF" RELATED [EC:1.15.1.1] +synonym: "SODS" RELATED [EC:1.15.1.1] +synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] +synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] +synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] +synonym: "zinc superoxide oxidoreductase" RELATED [] +xref: EC:1.15.1.1 +xref: MetaCyc:SUPEROX-DISMUT-RXN +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0004786 +name: Mn, Fe superoxide dismutase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the function is covered by an existing term. +is_obsolete: true +consider: GO:0004784 + +[Term] +id: GO:0004787 +name: thiamin-pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai] +synonym: "thiamin pyrophosphatase activity" EXACT [] +synonym: "thiamine pyrophosphatase activity" EXACT [] +synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6] +synonym: "TPPase activity" EXACT [] +xref: EC:3.6.1.- +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0004788 +name: thiamin diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate." [EC:2.7.6.2] +subset: gosubset_prok +synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] +synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] +synonym: "thiamin pyrophosphokinase activity" EXACT [] +synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] +synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] +synonym: "thiamine diphosphokinase activity" EXACT [EC:2.7.6.2] +synonym: "thiamine pyrophosphokinase activity" EXACT [] +synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] +synonym: "TPTase activity" EXACT [EC:2.7.6.2] +xref: EC:2.7.6.2 +xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0004789 +name: thiamin-phosphate diphosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate." [EC:2.5.1.3] +subset: gosubset_prok +synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3] +synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] +synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] +synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] +synonym: "thiamine-phosphate diphosphorylase activity" EXACT [EC:2.5.1.3] +synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] +synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3] +synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3] +synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3] +synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3] +xref: EC:2.5.1.3 +xref: MetaCyc:THI-P-SYN-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004790 +name: thioether S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96] +synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96] +synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96] +synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96] +xref: EC:2.1.1.96 +xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004791 +name: thioredoxin-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+." [EC:1.8.1.9, ISBN:0198547684] +subset: gosubset_prok +synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] +synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] +synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] +synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] +synonym: "thioredoxin disulfide reductase activity" EXACT [] +synonym: "thioredoxin reductase (NADPH) activity" EXACT [] +synonym: "thioredoxin-disulphide reductase activity" EXACT [] +synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] +xref: EC:1.8.1.9 +xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN +xref: Reactome:14367 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004792 +name: thiosulfate sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiosulfate + cyanide = SO3(2-) (sulfite) + thiocyanate." [EC:2.8.1.1] +subset: gosubset_prok +synonym: "rhodanase activity" EXACT [EC:2.8.1.1] +synonym: "rhodanese activity" RELATED [EC:2.8.1.1] +synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1] +synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1] +synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1] +synonym: "thiosulphate sulphurtransferase activity" EXACT [] +xref: EC:2.8.1.1 +xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0004793 +name: threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] +subset: gosubset_prok +synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5] +synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5] +synonym: "L-threonine aldolase activity" EXACT [] +xref: EC:4.1.2.5 +xref: MetaCyc:THREONINE-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004794 +name: L-threonine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] +comment: Note that this function was formerly EC:4.2.1.16. +subset: gosubset_prok +synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] +synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19] +synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19] +synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19] +synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19] +synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] +synonym: "threonine ammonia-lyase activity" EXACT [] +synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19] +synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19] +synonym: "threonine dehydratase activity" EXACT [] +xref: EC:4.3.1.19 +xref: MetaCyc:THREDEHYD-RXN +xref: UM-BBD_enzymeID:e0306 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0004795 +name: threonine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] +subset: gosubset_prok +synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1] +synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1] +synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1] +xref: EC:4.2.3.1 +xref: MetaCyc:THRESYN-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0004796 +name: thromboxane-A synthase activity +namespace: molecular_function +alt_id: GO:0008400 +def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromba-5,13-dienoate." [EC:5.3.99.5] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5] +synonym: "cytochrome P450 CYP5" NARROW [] +synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5] +synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5] +xref: EC:5.3.99.5 +xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN +xref: Reactome:14373 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0004797 +name: thymidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] +subset: gosubset_prok +synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21] +synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21] +synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] +synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] +xref: EC:2.7.1.21 +xref: MetaCyc:THYKI-RXN +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004798 +name: thymidylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] +subset: gosubset_prok +synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9] +synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] +synonym: "dTMP kinase activity" EXACT [] +synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] +synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9] +synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9] +synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9] +synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9] +synonym: "TMPK activity" EXACT [EC:2.7.4.9] +xref: EC:2.7.4.9 +xref: MetaCyc:DTMPKI-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019201 ! nucleotide kinase activity + +[Term] +id: GO:0004799 +name: thymidylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45] +subset: gosubset_prok +synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] +synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45] +synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] +synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45] +synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45] +xref: EC:2.1.1.45 +xref: MetaCyc:THYMIDYLATESYN-RXN +xref: Reactome:14376 +is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0004800 +name: thyroxine 5'-deiodinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10] +comment: Note that this was EC:3.8.1.4. +synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10] +synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] +synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] +synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10] +synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10] +synonym: "thyroxine 5' deiodinase activity" EXACT [] +synonym: "thyroxine deiodinase activity" BROAD [] +synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] +synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] +xref: EC:1.97.1.10 +xref: MetaCyc:THYROXINE-DEIODINASE-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004801 +name: transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] +subset: gosubset_prok +synonym: "dihydroxyacetone transferase activity" EXACT [EC:2.2.1.2] +synonym: "dihydroxyacetonetransferase activity" EXACT [EC:2.2.1.2] +synonym: "glycerone transferase activity" EXACT [EC:2.2.1.2] +synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" EXACT [EC:2.2.1.2] +xref: EC:2.2.1.2 +xref: MetaCyc:TRANSALDOL-RXN +xref: Reactome:15049 +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0004802 +name: transketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate." [EC:2.2.1.1] +subset: gosubset_prok +synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1] +synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] +synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] +xref: EC:2.2.1.1 +xref: MetaCyc:1TRANSKETO-RXN +xref: Reactome:15050 +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0004803 +name: transposase activity +namespace: molecular_function +def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0004804 +name: P-element encoded transposase activity +namespace: molecular_function +is_a: GO:0004803 ! transposase activity + +[Term] +id: GO:0004805 +name: trehalose-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] +subset: gosubset_prok +synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12] +synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12] +synonym: "trehalose phosphatase activity" EXACT [] +synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12] +xref: EC:3.1.3.12 +xref: MetaCyc:TREHALOSEPHOSPHA-RXN +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0004806 +name: triacylglycerol lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3] +subset: gosubset_prok +synonym: "amano AP" RELATED [EC:3.1.1.3] +synonym: "amano B" RELATED [EC:3.1.1.3] +synonym: "amano CE" RELATED [EC:3.1.1.3] +synonym: "amano CES" RELATED [EC:3.1.1.3] +synonym: "amano P" RELATED [EC:3.1.1.3] +synonym: "amno N-AP" RELATED [EC:3.1.1.3] +synonym: "butyrinase activity" EXACT [EC:3.1.1.3] +synonym: "cacordase activity" EXACT [EC:3.1.1.3] +synonym: "capalase L" RELATED [EC:3.1.1.3] +synonym: "GA 56" RELATED [EC:3.1.1.3] +synonym: "GEH" RELATED [EC:3.1.1.3] +synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] +synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] +synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] +synonym: "hepatic lipase" NARROW [EC:3.1.1.3] +synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] +synonym: "lipazin" RELATED [EC:3.1.1.3] +synonym: "liver lipase" NARROW [EC:3.1.1.3] +synonym: "meito MY 30" RELATED [EC:3.1.1.3] +synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] +synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] +synonym: "PPL" RELATED [EC:3.1.1.3] +synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] +synonym: "steapsin" RELATED [EC:3.1.1.3] +synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] +synonym: "triacetinase activity" EXACT [EC:3.1.1.3] +synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] +synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] +synonym: "tributyrase activity" RELATED [EC:3.1.1.3] +synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] +synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] +synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] +synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] +synonym: "triglyceride lipase activity" EXACT [EC:3.1.1.3] +synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] +synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] +synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] +synonym: "tweenase activity" EXACT [EC:3.1.1.3] +synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] +xref: EC:3.1.1.3 +xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN +xref: Reactome:15058 +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0016298 ! lipase activity + +[Term] +id: GO:0004807 +name: triose-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1] +subset: gosubset_prok +synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1] +synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1] +synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1] +synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1] +synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1] +synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1] +synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1] +xref: EC:5.3.1.1 +xref: MetaCyc:TRIOSEPISOMERIZATION-RXN +xref: Reactome:70450 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004808 +name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity +namespace: molecular_function +alt_id: GO:0016425 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61] +subset: gosubset_prok +synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61] +synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61] +synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61] +xref: EC:2.1.1.61 +xref: MetaCyc:2.1.1.61-RXN +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004809 +name: tRNA (guanine-N2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] +subset: gosubset_prok +synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32] +synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32] +synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32] +xref: EC:2.1.1.32 +xref: MetaCyc:TRNA-(GUANINE-N2-)-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0004810 +name: tRNA adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25] +subset: gosubset_prok +synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] +synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] +synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25] +synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] +synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25] +synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] +synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] +synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] +synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] +xref: EC:2.7.7.25 +xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004811 +name: tRNA isopentenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine." [EC:2.5.1.8] +subset: gosubset_prok +synonym: "delta2-isopentenyl pyrophosphate:transfer ribonucleic acid delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.8] +synonym: "delta2-isopentenyl pyrophosphate:tRNA-delta2-isopentenyl transferase activity" EXACT [EC:2.5.1.8] +synonym: "IPP transferase activity" EXACT [EC:2.5.1.8] +synonym: "isopentenyl-diphosphate:tRNA isopentenyltransferase activity" EXACT [EC:2.5.1.8] +synonym: "transfer ribonucleate isopentenyltransferase activity" EXACT [EC:2.5.1.8] +xref: EC:2.5.1.8 +xref: MetaCyc:TRNA-ISOPENTENYLTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004812 +name: aminoacyl-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. +subset: gosubset_prok +synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] +xref: EC:6.1.1.- +is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds + +[Term] +id: GO:0004813 +name: alanine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] +subset: gosubset_prok +synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7] +synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7] +synonym: "alanine translase activity" EXACT [EC:6.1.1.7] +synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7] +synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7] +synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7] +synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7] +synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7] +synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7] +synonym: "alanyl-tRNA synthetase activity" EXACT [] +synonym: "AlaRS" RELATED [EC:6.1.1.7] +synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7] +xref: EC:6.1.1.7 +xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004814 +name: arginine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] +subset: gosubset_prok +synonym: "arginine translase activity" EXACT [EC:6.1.1.19] +synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19] +synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19] +synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19] +synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19] +synonym: "arginyl-tRNA synthetase activity" EXACT [] +synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19] +xref: EC:6.1.1.19 +xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004815 +name: aspartate-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] +subset: gosubset_prok +synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12] +synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12] +synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12] +synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12] +synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12] +synonym: "aspartyl-tRNA synthetase activity" EXACT [] +synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12] +xref: EC:6.1.1.12 +xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004816 +name: asparagine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)." [EC:6.1.1.22] +subset: gosubset_prok +synonym: "asparagine translase activity" EXACT [EC:6.1.1.22] +synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22] +synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22] +synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22] +synonym: "asparaginyl-tRNA synthetase activity" EXACT [] +synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22] +synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22] +xref: EC:6.1.1.22 +xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004817 +name: cysteine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] +subset: gosubset_prok +synonym: "cysteine translase activity" EXACT [EC:6.1.1.16] +synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16] +synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16] +synonym: "cysteinyl-tRNA synthetase activity" EXACT [] +synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16] +xref: EC:6.1.1.16 +xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004818 +name: glutamate-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] +subset: gosubset_prok +synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17] +synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17] +synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17] +synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17] +synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17] +synonym: "glutamyl-tRNA synthetase activity" EXACT [] +synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17] +xref: EC:6.1.1.17 +xref: MetaCyc:GLURS-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004819 +name: glutamine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] +subset: gosubset_prok +synonym: "GlnRS" RELATED [EC:6.1.1.18] +synonym: "glutamine translase activity" EXACT [EC:6.1.1.18] +synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18] +synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] +synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18] +synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18] +synonym: "glutaminyl-tRNA synthetase activity" EXACT [] +synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18] +xref: EC:6.1.1.18 +xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004820 +name: glycine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] +subset: gosubset_prok +synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14] +synonym: "glycyl translase activity" EXACT [EC:6.1.1.14] +synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14] +synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14] +synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14] +synonym: "glycyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.14 +xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004821 +name: histidine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] +subset: gosubset_prok +synonym: "histidine translase activity" EXACT [EC:6.1.1.21] +synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21] +synonym: "histidyl-tRNA synthetase activity" EXACT [] +synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21] +xref: EC:6.1.1.21 +xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004822 +name: isoleucine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)." [EC:6.1.1.5] +subset: gosubset_prok +synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5] +synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5] +synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5] +synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5] +synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5] +synonym: "isoleucyl-tRNA synthetase activity" EXACT [] +synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5] +xref: EC:6.1.1.5 +xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004823 +name: leucine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)." [EC:6.1.1.4] +subset: gosubset_prok +synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4] +synonym: "leucine translase activity" EXACT [EC:6.1.1.4] +synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4] +synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4] +synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4] +synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4] +synonym: "leucyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.4 +xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004824 +name: lysine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] +subset: gosubset_prok +synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6] +synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6] +synonym: "lysine translase activity" EXACT [EC:6.1.1.6] +synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6] +synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6] +synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6] +synonym: "lysyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.6 +xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004825 +name: methionine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] +subset: gosubset_prok +synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10] +synonym: "methionine translase activity" EXACT [EC:6.1.1.10] +synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10] +synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10] +synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10] +synonym: "methionyl-tRNA synthetase activity" EXACT [] +synonym: "MetRS activity" EXACT [EC:6.1.1.10] +xref: EC:6.1.1.10 +xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004826 +name: phenylalanine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] +subset: gosubset_prok +synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20] +synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20] +synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.20 +xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004827 +name: proline-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] +subset: gosubset_prok +synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15] +synonym: "proline translase activity" EXACT [EC:6.1.1.15] +synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15] +synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15] +synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15] +synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15] +synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15] +synonym: "prolyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.15 +xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004828 +name: serine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] +subset: gosubset_prok +synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11] +synonym: "serine translase activity" EXACT [EC:6.1.1.11] +synonym: "SerRS activity" EXACT [EC:6.1.1.11] +synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11] +synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11] +synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11] +synonym: "seryl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.11 +xref: MetaCyc:SERINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004829 +name: threonine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] +subset: gosubset_prok +synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3] +synonym: "threonine translase activity" EXACT [EC:6.1.1.3] +synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] +synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3] +synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] +synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3] +synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3] +synonym: "threonyl-tRNA synthetase activity" EXACT [] +synonym: "TRS" RELATED [EC:6.1.1.3] +xref: EC:6.1.1.3 +xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004830 +name: tryptophan-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] +subset: gosubset_prok +synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2] +synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] +synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] +synonym: "TrpRS activity" EXACT [EC:6.1.1.2] +synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2] +synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.2 +xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004831 +name: tyrosine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)." [EC:6.1.1.1] +subset: gosubset_prok +synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1] +synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] +synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] +synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1] +synonym: "tyrosyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.1 +xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004832 +name: valine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)." [EC:6.1.1.9] +subset: gosubset_prok +synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9] +synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9] +synonym: "valine translase activity" EXACT [EC:6.1.1.9] +synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9] +synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9] +synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9] +synonym: "valyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.9 +xref: MetaCyc:VALINE--TRNA-LIGASE-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004833 +name: tryptophan 2,3-dioxygenase activity +namespace: molecular_function +alt_id: GO:0004426 +def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] +subset: gosubset_prok +synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] +synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] +synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] +synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11] +synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11] +synonym: "TDO" RELATED [EC:1.13.11.11] +synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] +synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] +synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] +synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] +synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] +xref: EC:1.13.11.11 +xref: MetaCyc:INDOLEAMINE-PYRROLE-2\,3-DIOXYGENASE-RXN +xref: MetaCyc:TRYPTOPHAN-2\,3-DIOXYGENASE-RXN +xref: Reactome:15133 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004834 +name: tryptophan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [EC:4.2.1.20] +subset: gosubset_prok +synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20] +synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20] +synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] +synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20] +synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20] +synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20] +xref: EC:4.2.1.20 +xref: MetaCyc:TRYPSYN-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004835 +name: tubulin-tyrosine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] +synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25] +synonym: "TTL activity" EXACT [EC:6.3.2.25] +synonym: "tubulinyl-tyrosine ligase activity" EXACT [] +xref: EC:6.3.2.25 +xref: MetaCyc:6.3.2.25-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004836 +name: tyramine-beta hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004837 +name: tyrosine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] +synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25] +synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25] +synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25] +synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25] +xref: EC:4.1.1.25 +xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004838 +name: tyrosine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] +subset: gosubset_prok +synonym: "glutamic phenylpyruvic aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" EXACT [EC:2.6.1.5] +synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "L-tyrosine aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "phenylalanine aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "phenylalanine transaminase activity" EXACT [EC:2.6.1.5] +synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.5] +synonym: "phenylpyruvate transaminase activity" EXACT [EC:2.6.1.5] +synonym: "phenylpyruvic acid transaminase activity" EXACT [EC:2.6.1.5] +synonym: "TyrAT activity" EXACT [EC:2.6.1.5] +synonym: "tyrosine aminotransferase activity" EXACT [] +synonym: "tyrosine-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.5] +synonym: "tyrosine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.5] +xref: EC:2.6.1.5 +xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN +xref: Reactome:15141 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004839 +name: ubiquitin activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner." [http://www.bostonbiochem.com/E-301.html, PMID:10072378] +synonym: "E1" EXACT [] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0004842 +name: ubiquitin-protein ligase activity +namespace: molecular_function +alt_id: GO:0004840 +alt_id: GO:0004841 +def: "Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407] +subset: gosubset_prok +synonym: "E2" NARROW [] +synonym: "E3" NARROW [] +synonym: "ubiquitin activity" RELATED [EC:6.3.2.19] +synonym: "ubiquitin conjugating enzyme activity" EXACT [] +synonym: "ubiquitin ligase activity" EXACT [] +synonym: "ubiquitin protein ligase activity" EXACT [] +synonym: "ubiquitin protein-ligase activity" EXACT [] +synonym: "ubiquitin-activating enzyme" EXACT [] +synonym: "ubiquitin-conjugating enzyme activity" EXACT [] +synonym: "ubiquitin-ligase activity" EXACT [] +synonym: "ubiquitin:protein-lysine N-ligase (AMP-forming) activity" EXACT [EC:6.3.2.19] +xref: EC:6.3.2.19 +xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN +xref: Reactome:15168 +xref: Reactome:15171 +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0004843 +name: ubiquitin-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups." [ISBN:0120793709] +comment: Note that this term encompasses hydrolysis of any type of bonds formed between ubiquitin and another molecule. +subset: gosubset_prok +synonym: "UBP" NARROW [] +synonym: "UCH2" NARROW [] +is_a: GO:0019783 ! small conjugating protein-specific protease activity + +[Term] +id: GO:0004844 +name: uracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, PMID:9224623] +subset: gosubset_prok +synonym: "uracil-DNA glycosylase activity" EXACT [] +xref: EC:3.2.2.- +xref: Reactome:15174 +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0004845 +name: uracil phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.9] +subset: gosubset_prok +synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9] +synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9] +synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9] +synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9] +synonym: "UPRTase activity" EXACT [EC:2.4.2.9] +synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] +synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] +synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9] +synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9] +xref: EC:2.4.2.9 +xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN +xref: Reactome:15175 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004846 +name: urate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2." [EC:1.7.3.3] +subset: gosubset_prok +synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3] +synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3] +synonym: "uricase activity" EXACT [EC:1.7.3.3] +synonym: "uricase II activity" NARROW [EC:1.7.3.3] +xref: EC:1.7.3.3 +xref: MetaCyc:URATE-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0832 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0004847 +name: urea carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + urea + CO2 = ADP + phosphate + urea-1-carboxylate." [EC:6.3.4.6] +subset: gosubset_prok +synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6] +synonym: "UALase activity" EXACT [EC:6.3.4.6] +synonym: "UCA activity" EXACT [EC:6.3.4.6] +synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6] +synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6] +synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6] +synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6] +synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6] +synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6] +xref: EC:6.3.4.6 +xref: MetaCyc:UREA-CARBOXYLASE-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004848 +name: ureidoglycolate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2." [EC:3.5.3.19] +subset: gosubset_prok +synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19] +xref: EC:3.5.3.19 +xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004849 +name: uridine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] +subset: gosubset_prok +synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48] +synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48] +synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48] +synonym: "uridine kinase reaction" EXACT [] +synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48] +synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48] +synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48] +xref: EC:2.7.1.48 +xref: MetaCyc:URIDINEKIN-RXN +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0004850 +name: uridine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] +subset: gosubset_prok +synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] +synonym: "UPase activity" EXACT [EC:2.4.2.3] +synonym: "UPH" RELATED [EC:2.4.2.3] +synonym: "UrdPase activity" EXACT [EC:2.4.2.3] +synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3] +xref: EC:2.4.2.3 +xref: MetaCyc:URPHOS-RXN +xref: Reactome:15196 +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0004851 +name: uroporphyrin-III C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] +subset: gosubset_prok +synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107] +synonym: "CobA" RELATED [EC:2.1.1.107] +synonym: "CysG" RELATED [EC:2.1.1.107] +synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] +synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107] +synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] +synonym: "SirA" RELATED [EC:2.1.1.107] +synonym: "SUMT activity" EXACT [EC:2.1.1.107] +synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107] +synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] +synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107] +synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] +synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] +synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] +xref: EC:2.1.1.107 +xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004852 +name: uroporphyrinogen-III synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O." [EC:4.2.1.75] +subset: gosubset_prok +synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75] +synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75] +synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75] +synonym: "URO-synthase activity" EXACT [EC:4.2.1.75] +synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75] +synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75] +synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75] +synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75] +xref: EC:4.2.1.75 +xref: MetaCyc:UROGENIIISYN-RXN +xref: Reactome:15200 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004853 +name: uroporphyrinogen decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] +subset: gosubset_prok +synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37] +synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37] +synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37] +synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37] +synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37] +xref: EC:4.1.1.37 +xref: MetaCyc:UROGENDECARBOX-RXN +xref: Reactome:15202 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004854 +name: xanthine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] +subset: gosubset_prok +synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4] +synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] +synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] +synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] +synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] +synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] +xref: EC:1.17.1.4 +xref: MetaCyc:XANTHINE-DEHYDROGENASE-RXN +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0004855 +name: xanthine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2." [EC:1.17.3.2] +subset: gosubset_prok +synonym: "hypoxanthine oxidase activity" EXACT [EC:1.17.3.2] +synonym: "hypoxanthine-xanthine oxidase activity" EXACT [EC:1.17.3.2] +synonym: "hypoxanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] +synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] +synonym: "Schardinger enzyme activity" EXACT [EC:1.17.3.2] +synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] +synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] +synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] +synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] +synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2] +xref: EC:1.17.3.2 +xref: MetaCyc:XANTHINE-OXIDASE-RXN +xref: Reactome:15204 +xref: UM-BBD_enzymeID:e0781 +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0004856 +name: xylulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-xylulose = ADP + D-xylulose 5-phosphate." [EC:2.7.1.17] +subset: gosubset_prok +synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17] +synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17] +synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17] +synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17] +xref: EC:2.7.1.17 +xref: MetaCyc:XYLULOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004857 +name: enzyme inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of an enzyme." [GOC:ai] +subset: gosubset_prok +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0004858 +name: dUTP pyrophosphatase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0004859 +name: phospholipase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] +is_a: GO:0055102 ! lipase inhibitor activity + +[Term] +id: GO:0004860 +name: protein kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0019210 ! kinase inhibitor activity +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0004861 +name: cyclin-dependent protein kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah] +synonym: "CDK inhibitor" RELATED [] +synonym: "cyclin dependent kinase inhibitor" RELATED [] +synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] +synonym: "cyclin-dependent kinase inhibitor" RELATED [] +xref: Reactome:15226 +is_a: GO:0016538 ! cyclin-dependent protein kinase regulator activity +is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity + +[Term] +id: GO:0004862 +name: cAMP-dependent protein kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] +is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity + +[Term] +id: GO:0004863 +name: diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity +namespace: molecular_function +synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] +is_a: GO:0008426 ! protein kinase C inhibitor activity + +[Term] +id: GO:0004864 +name: protein phosphatase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins." [GOC:ai] +is_a: GO:0019212 ! phosphatase inhibitor activity + +[Term] +id: GO:0004865 +name: type 1 serine/threonine specific protein phosphatase inhibitor activity +namespace: molecular_function +is_a: GO:0004864 ! protein phosphatase inhibitor activity + +[Term] +id: GO:0004866 +name: endopeptidase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] +subset: gosubset_prok +synonym: "alpha-2 macroglobulin" RELATED [] +synonym: "endoproteinase inhibitor" EXACT [] +synonym: "proteinase inhibitor" BROAD [] +is_a: GO:0030414 ! protease inhibitor activity + +[Term] +id: GO:0004867 +name: serine-type endopeptidase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] +subset: gosubset_prok +synonym: "serine protease inhibitor activity" EXACT [] +synonym: "serine proteinase inhibitor activity" EXACT [] +synonym: "serpin activity" NARROW [] +xref: Reactome:15233 +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0004868 +name: serpin +namespace: molecular_function +def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0004867 + +[Term] +id: GO:0004869 +name: cysteine protease inhibitor activity +namespace: molecular_function +alt_id: GO:0004870 +subset: gosubset_prok +synonym: "thiol protease inhibitor" EXACT [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0004871 +name: signal transducer activity +namespace: molecular_function +def: "Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0060089 ! molecular transducer activity + +[Term] +id: GO:0004872 +name: receptor activity +namespace: molecular_function +def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +synonym: "receptor guanylate cyclase activity" NARROW [] +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0004873 +name: asialoglycoprotein receptor activity +namespace: molecular_function +def: "The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane." [UniProtKB:P24721] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0004874 +name: aryl hydrocarbon receptor activity +namespace: molecular_function +def: "Combining with an aryl hydrocarbon to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0004875 +name: complement receptor activity +namespace: molecular_function +def: "Combining with any component or product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. +is_a: GO:0001848 ! complement binding +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0004876 +name: complement component C3a receptor activity +namespace: molecular_function +def: "Combining with the C3a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0004877 +name: complement component C3b receptor activity +namespace: molecular_function +def: "Combining with the C3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0001850 ! complement component C3a binding +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0004878 +name: complement component C5a receptor activity +namespace: molecular_function +def: "Combining with the C5a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0001856 ! complement component C5a binding +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0004879 +name: ligand-dependent nuclear receptor activity +namespace: molecular_function +def: "A ligand-dependent receptor found in the nucleus of the cell." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +synonym: "nuclear hormone receptor" NARROW [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0004880 +name: juvenile hormone receptor activity +namespace: molecular_function +def: "Combining with juvenile hormone to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0004879 ! ligand-dependent nuclear receptor activity + +[Term] +id: GO:0004882 +name: androgen receptor activity +namespace: molecular_function +def: "Combining with an androgen to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0004883 +name: glucocorticoid receptor activity +namespace: molecular_function +def: "Combining with a glucocorticoid to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0004884 +name: ecdysteroid hormone receptor activity +namespace: molecular_function +def: "Combining with ecdysteroid hormone to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0004886 +name: retinoid-X receptor activity +namespace: molecular_function +synonym: "RXR" EXACT [] +is_a: GO:0003708 ! retinoic acid receptor activity + +[Term] +id: GO:0004887 +name: thyroid hormone receptor activity +namespace: molecular_function +def: "Combining with thyroid hormone to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0004879 ! ligand-dependent nuclear receptor activity + +[Term] +id: GO:0004888 +name: transmembrane receptor activity +namespace: molecular_function +def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle." [GOC:go_curators, http://en.wikipedia.org/] +subset: gosubset_prok +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0004889 +name: nicotinic acetylcholine-activated cation-selective channel activity +namespace: molecular_function +alt_id: GO:0016904 +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0004890 +name: GABA-A receptor activity +namespace: molecular_function +def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. +is_a: GO:0016917 ! GABA receptor activity + +[Term] +id: GO:0004891 +name: glycine-inhibited chloride channel activity +namespace: molecular_function +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'receptor activity ; GO:0004872'. +is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity +is_a: GO:0005254 ! chloride channel activity + +[Term] +id: GO:0004892 +name: B cell receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes the receptor type, and not an activity. +is_obsolete: true +consider: GO:0003823 + +[Term] +id: GO:0004894 +name: T cell receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes a receptor type, and not an activity. +is_obsolete: true +consider: GO:0032394 +consider: GO:0032395 +consider: GO:0042605 + +[Term] +id: GO:0004895 +name: cell adhesion receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with cell adhesion molecules to initiate a change in cell activity." [GOC:ai] +comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0030246 +consider: GO:0050839 + +[Term] +id: GO:0004896 +name: cytokine receptor activity +namespace: molecular_function +alt_id: GO:0004907 +def: "Combining with a cytokine to initiate a change in cell activity." [GOC:add, GOC:mah] +synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] +synonym: "IL receptor" NARROW [] +synonym: "interleukin receptor activity" NARROW [] +is_a: GO:0004888 ! transmembrane receptor activity +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0004897 +name: ciliary neurotrophic factor receptor activity +namespace: molecular_function +synonym: "gp130" NARROW [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004898 +name: gp130 +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0004897 +consider: GO:0004915 +consider: GO:0004921 +consider: GO:0005062 + +[Term] +id: GO:0004899 +name: leukemia inhibitory factor receptor beta-protein activity +namespace: molecular_function +is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity +is_a: GO:0005062 ! hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity + +[Term] +id: GO:0004900 +name: erythropoietin receptor activity +namespace: molecular_function +def: "Combining with erythropoietin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004901 +name: granulocyte macrophage colony-stimulating factor receptor activity +namespace: molecular_function +alt_id: GO:0030525 +def: "Combining with granulocyte macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah] +synonym: "CSF-2" RELATED [] +synonym: "GM-CSF receptor activity" EXACT [] +synonym: "GMC-SF receptor activity" EXACT [] +is_a: GO:0004900 ! erythropoietin receptor activity + +[Term] +id: GO:0004902 +name: granulocyte colony-stimulating factor receptor activity +namespace: molecular_function +alt_id: GO:0030524 +def: "Combining with granulocyte colony-stimulating factor to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004903 +name: growth hormone receptor activity +namespace: molecular_function +def: "Combining with growth hormone to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004904 +name: interferon receptor activity +namespace: molecular_function +def: "Combining with an interferon to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0004905 +name: type I interferon receptor activity +namespace: molecular_function +def: "Combining with a type I interferon to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "interferon-alpha receptor activity" NARROW [] +synonym: "interferon-alpha/beta receptor activity" NARROW [] +synonym: "interferon-beta receptor activity" NARROW [] +synonym: "interferon-delta receptor activity" NARROW [] +synonym: "interferon-epsilon receptor activity" NARROW [] +synonym: "interferon-kappa receptor activity" NARROW [] +synonym: "interferon-omega receptor activity" NARROW [] +synonym: "interferon-tau receptor activity" NARROW [] +synonym: "interferon-zeta receptor activity" NARROW [] +is_a: GO:0004904 ! interferon receptor activity +is_a: GO:0019962 ! type I interferon binding + +[Term] +id: GO:0004906 +name: interferon-gamma receptor activity +namespace: molecular_function +def: "Combining with interferon-gamma to initiate a change in cell activity. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] +synonym: "type II interferon receptor activity" EXACT [] +is_a: GO:0004904 ! interferon receptor activity +is_a: GO:0019964 ! interferon-gamma binding + +[Term] +id: GO:0004908 +name: interleukin-1 receptor activity +namespace: molecular_function +def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] +synonym: "IL-1R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019966 ! interleukin-1 binding + +[Term] +id: GO:0004909 +name: interleukin-1, Type I, activating receptor activity +namespace: molecular_function +synonym: "IL-1 type I, activating receptor" EXACT [] +is_a: GO:0004908 ! interleukin-1 receptor activity +is_a: GO:0019967 ! interleukin-1, Type I, activating binding + +[Term] +id: GO:0004910 +name: interleukin-1, Type II, blocking receptor activity +namespace: molecular_function +synonym: "IL-1 type II, blocking receptor" EXACT [] +is_a: GO:0004908 ! interleukin-1 receptor activity +is_a: GO:0019968 ! interleukin-1, Type II, blocking binding + +[Term] +id: GO:0004911 +name: interleukin-2 receptor activity +namespace: molecular_function +def: "Combining with interleukin-2 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-2R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019976 ! interleukin-2 binding + +[Term] +id: GO:0004912 +name: interleukin-3 receptor activity +namespace: molecular_function +def: "Combining with interleukin-3 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-3R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019978 ! interleukin-3 binding + +[Term] +id: GO:0004913 +name: interleukin-4 receptor activity +namespace: molecular_function +def: "Combining with interleukin-4 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-4R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019979 ! interleukin-4 binding + +[Term] +id: GO:0004914 +name: interleukin-5 receptor activity +namespace: molecular_function +def: "Combining with interleukin-5 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-5R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019980 ! interleukin-5 binding + +[Term] +id: GO:0004915 +name: interleukin-6 receptor activity +namespace: molecular_function +def: "Combining with interleukin-6 to initiate a change in cell activity." [GOC:jl] +synonym: "gp130" NARROW [] +synonym: "IL-6R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019981 ! interleukin-6 binding + +[Term] +id: GO:0004917 +name: interleukin-7 receptor activity +namespace: molecular_function +def: "Combining with interleukin-7 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-7R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019982 ! interleukin-7 binding + +[Term] +id: GO:0004918 +name: interleukin-8 receptor activity +namespace: molecular_function +def: "Combining with interleukin-8 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-8R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0016494 ! C-X-C chemokine receptor activity +is_a: GO:0019959 ! interleukin-8 binding + +[Term] +id: GO:0004919 +name: interleukin-9 receptor activity +namespace: molecular_function +def: "Combining with interleukin-9 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-9R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019983 ! interleukin-9 binding + +[Term] +id: GO:0004920 +name: interleukin-10 receptor activity +namespace: molecular_function +def: "Combining with interleukin-10 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-10R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019969 ! interleukin-10 binding + +[Term] +id: GO:0004921 +name: interleukin-11 receptor activity +namespace: molecular_function +def: "Combining with interleukin-11 to initiate a change in cell activity." [GOC:jl] +synonym: "gp130" NARROW [] +synonym: "IL-11R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019970 ! interleukin-11 binding + +[Term] +id: GO:0004923 +name: leukemia inhibitory factor receptor activity +namespace: molecular_function +def: "Combining with leukemia inhibitory factor to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004924 +name: oncostatin-M receptor activity +namespace: molecular_function +def: "Combining with oncostatin-M to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004925 +name: prolactin receptor activity +namespace: molecular_function +def: "Combining with prolactin to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004926 +name: non-G-protein coupled 7TM receptor activity +namespace: molecular_function +subset: gosubset_prok +synonym: "non G protein coupled 7TM receptor activity" EXACT [] +synonym: "non-G-protein-coupled 7TM receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0004927 +name: sevenless receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a gene product rather than an activity. +is_obsolete: true +consider: GO:0004714 +consider: GO:0004926 +consider: GO:0008288 + +[Term] +id: GO:0004928 +name: frizzled receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product rather than an activity. +is_obsolete: true +replaced_by: GO:0042813 +consider: GO:0016055 + +[Term] +id: GO:0004929 +name: frizzled-2 receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product rather than an activity. +is_obsolete: true +replaced_by: GO:0042813 +consider: GO:0007223 + +[Term] +id: GO:0004930 +name: G-protein coupled receptor activity +namespace: molecular_function +alt_id: GO:0016526 +def: "A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph, GOC:tb, http://www.iuphar-db.org] +subset: gosubset_prok +synonym: "G protein coupled receptor activity" EXACT [] +synonym: "G protein linked receptor activity" EXACT [] +synonym: "G-protein coupled receptor activity, unknown ligand" EXACT [] +synonym: "G-protein linked receptor activity" EXACT [] +synonym: "G-protein-coupled receptor activity" EXACT [] +synonym: "GPCR activity" EXACT [] +synonym: "ligand-dependent GPCR activity" EXACT [] +synonym: "orphan G protein coupled receptor activity" EXACT [] +synonym: "orphan G-protein coupled receptor activity" EXACT [] +synonym: "orphan GPCR activity" EXACT [] +xref: Reactome:35 +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0004931 +name: ATP-gated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:9755289] +comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. +synonym: "P2X activity" RELATED [] +synonym: "purinoceptor" BROAD [] +synonym: "purinoreceptor" BROAD [] +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0004932 +name: mating-type factor pheromone receptor activity +namespace: molecular_function +def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph] +subset: gosubset_prok +is_a: GO:0016503 ! pheromone receptor activity + +[Term] +id: GO:0004933 +name: mating-type a-factor pheromone receptor activity +namespace: molecular_function +def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] +synonym: "class D G protein coupled receptor activity" BROAD [] +synonym: "class D G-protein coupled receptor activity" BROAD [] +synonym: "class D G-protein-coupled receptor activity" BROAD [] +synonym: "class D GPCR activity" BROAD [] +is_a: GO:0004932 ! mating-type factor pheromone receptor activity + +[Term] +id: GO:0004934 +name: mating-type alpha-factor pheromone receptor activity +namespace: molecular_function +def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] +synonym: "class D G protein coupled receptor activity" BROAD [] +synonym: "class D G-protein coupled receptor activity" BROAD [] +synonym: "class D G-protein-coupled receptor activity" BROAD [] +synonym: "class D GPCR activity" BROAD [] +is_a: GO:0004932 ! mating-type factor pheromone receptor activity + +[Term] +id: GO:0004935 +name: adrenoceptor activity +namespace: molecular_function +synonym: "adrenergic receptor" EXACT [] +is_a: GO:0008227 ! amine receptor activity + +[Term] +id: GO:0004936 +name: alpha-adrenergic receptor activity +namespace: molecular_function +synonym: "alpha adrenoceptor" EXACT [] +is_a: GO:0004935 ! adrenoceptor activity + +[Term] +id: GO:0004937 +name: alpha1-adrenergic receptor activity +namespace: molecular_function +synonym: "alpha1 adrenoceptor" EXACT [] +is_a: GO:0004936 ! alpha-adrenergic receptor activity + +[Term] +id: GO:0004938 +name: alpha2-adrenergic receptor activity +namespace: molecular_function +synonym: "alpha2 adrenoceptor" EXACT [] +is_a: GO:0004936 ! alpha-adrenergic receptor activity + +[Term] +id: GO:0004939 +name: beta-adrenergic receptor activity +namespace: molecular_function +synonym: "beta adrenoceptor" EXACT [] +is_a: GO:0004935 ! adrenoceptor activity + +[Term] +id: GO:0004940 +name: beta1-adrenergic receptor activity +namespace: molecular_function +synonym: "beta1 adrenoceptor" EXACT [] +is_a: GO:0004939 ! beta-adrenergic receptor activity + +[Term] +id: GO:0004941 +name: beta2-adrenergic receptor activity +namespace: molecular_function +synonym: "beta2 adrenoceptor" EXACT [] +is_a: GO:0004939 ! beta-adrenergic receptor activity + +[Term] +id: GO:0004942 +name: anaphylatoxin receptor activity +namespace: molecular_function +def: "Combining with anaphylatoxin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004943 +name: C3a anaphylatoxin receptor activity +namespace: molecular_function +def: "Combining with anaphylatoxin C3a to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004942 ! anaphylatoxin receptor activity + +[Term] +id: GO:0004944 +name: C5a anaphylatoxin receptor activity +namespace: molecular_function +def: "Combining with anaphylatoxin C5a to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004942 ! anaphylatoxin receptor activity + +[Term] +id: GO:0004945 +name: angiotensin type II receptor activity +namespace: molecular_function +is_a: GO:0001595 ! angiotensin receptor activity + +[Term] +id: GO:0004946 +name: bombesin receptor activity +namespace: molecular_function +def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004947 +name: bradykinin receptor activity +namespace: molecular_function +def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004948 +name: calcitonin receptor activity +namespace: molecular_function +def: "Combining with calcitonin to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004949 +name: cannabinoid receptor activity +namespace: molecular_function +def: "Combining with cannabinoids to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1279] +synonym: "cannaboid receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004950 +name: chemokine receptor activity +namespace: molecular_function +def: "Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity." [IUPHAR_GPCR:1280, PMID:8662823] +is_a: GO:0001637 ! G-protein chemoattractant receptor activity +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0004951 +name: cholecystokinin receptor activity +namespace: molecular_function +def: "Combining with cholecystokinin, a 33-amino acid peptide secreted by the upper intestinal mucosa and also found in the central nervous system, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004952 +name: dopamine receptor activity +namespace: molecular_function +def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282] +is_a: GO:0008227 ! amine receptor activity +is_a: GO:0030594 ! neurotransmitter receptor activity +is_a: GO:0035240 ! dopamine binding + +[Term] +id: GO:0004953 +name: icosanoid receptor activity +namespace: molecular_function +def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] +synonym: "eicosanoid receptor activity" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004954 +name: prostanoid receptor activity +namespace: molecular_function +def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004953 ! icosanoid receptor activity + +[Term] +id: GO:0004955 +name: prostaglandin receptor activity +namespace: molecular_function +def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004954 ! prostanoid receptor activity + +[Term] +id: GO:0004956 +name: prostaglandin D receptor activity +namespace: molecular_function +def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "PGD receptor activity" RELATED [] +synonym: "PGD(2) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0004957 +name: prostaglandin E receptor activity +namespace: molecular_function +def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "PGE receptor activity" RELATED [] +synonym: "PGE(2) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0004958 +name: prostaglandin F receptor activity +namespace: molecular_function +def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "PGF receptor activity" RELATED [] +synonym: "PGF(2-alpha) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0004960 +name: thromboxane receptor activity +namespace: molecular_function +def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "TXA receptor activity" EXACT [] +is_a: GO:0004954 ! prostanoid receptor activity + +[Term] +id: GO:0004961 +name: thromboxane A2 receptor activity +namespace: molecular_function +def: "Combining with thromboxane A2 (TXA(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "TXA(2) receptor activity" EXACT [] +is_a: GO:0004960 ! thromboxane receptor activity + +[Term] +id: GO:0004962 +name: endothelin receptor activity +namespace: molecular_function +def: "Combining with endothelin to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1283] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004963 +name: follicle-stimulating hormone receptor activity +namespace: molecular_function +def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] +synonym: "follicle stimulating hormone receptor activity" EXACT [] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004964 +name: lutropin-choriogonadotropic hormone receptor activity +namespace: molecular_function +alt_id: GO:0004976 +def: "Combining with lutropin-choriogonadotropic hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004965 +name: GABA-B receptor activity +namespace: molecular_function +def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors." [GOC:ai, IUPHAR_RECEPTOR:1276] +is_a: GO:0008066 ! glutamate receptor activity +is_a: GO:0016917 ! GABA receptor activity + +[Term] +id: GO:0004966 +name: galanin receptor activity +namespace: molecular_function +def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004967 +name: glucagon receptor activity +namespace: molecular_function +def: "Combining with glucagon to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004968 +name: gonadotropin-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004969 +name: histamine receptor activity +namespace: molecular_function +def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +is_a: GO:0008227 ! amine receptor activity + +[Term] +id: GO:0004970 +name: ionotropic glutamate receptor activity +namespace: molecular_function +def: "Combining with glutamate to initiate a change in cell activity through the regulation of ion channels." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. +subset: gosubset_prok +is_a: GO:0008066 ! glutamate receptor activity + +[Term] +id: GO:0004971 +name: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity +namespace: molecular_function +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'inotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. +is_a: GO:0004970 ! ionotropic glutamate receptor activity + +[Term] +id: GO:0004972 +name: N-methyl-D-aspartate selective glutamate receptor activity +namespace: molecular_function +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'inotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. +synonym: "NMDA receptor" EXACT [] +is_a: GO:0004970 ! ionotropic glutamate receptor activity + +[Term] +id: GO:0004973 +name: N-methyl-D-aspartate receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0004974 +name: leukotriene receptor activity +namespace: molecular_function +def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004977 +name: melanocortin receptor activity +namespace: molecular_function +def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004978 +name: adrenocorticotropin receptor activity +namespace: molecular_function +def: "Combining with adrenocorticotropin to initiate a change in cell activity." [GOC:ai] +synonym: "ACTH receptor activity" EXACT [] +synonym: "adrenocorticotropic hormone receptor activity" EXACT [] +is_a: GO:0004977 ! melanocortin receptor activity +is_a: GO:0008188 ! neuropeptide receptor activity +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0004979 +name: beta-endorphin receptor activity +namespace: molecular_function +def: "Combining with beta-endorphin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004977 ! melanocortin receptor activity +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004980 +name: melanocyte stimulating hormone receptor activity +namespace: molecular_function +def: "Combining with melanocyte stimulating hormone to initiate a change in cell activity." [GOC:jl, UniProtKB:Q01726] +synonym: "melanophore stimulating hormone receptor activity" EXACT [] +synonym: "MSH receptor activity" BROAD [] +synonym: "MSHR activity" BROAD [] +is_a: GO:0004977 ! melanocortin receptor activity +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0004981 +name: muscarinic acetylcholine receptor activity +namespace: molecular_function +is_a: GO:0008227 ! amine receptor activity +is_a: GO:0015464 ! acetylcholine receptor activity + +[Term] +id: GO:0004982 +name: N-formyl peptide receptor activity +namespace: molecular_function +def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] +synonym: "Fmet-leu-phe receptor" EXACT [] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004983 +name: neuropeptide Y receptor activity +namespace: molecular_function +def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004984 +name: olfactory receptor activity +namespace: molecular_function +def: "Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell." [GOC:dph] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004985 +name: opioid receptor activity +namespace: molecular_function +def: "Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004986 +name: delta-opioid receptor activity +namespace: molecular_function +is_a: GO:0004985 ! opioid receptor activity + +[Term] +id: GO:0004987 +name: kappa-opioid receptor activity +namespace: molecular_function +is_a: GO:0004985 ! opioid receptor activity + +[Term] +id: GO:0004988 +name: mu-opioid receptor activity +namespace: molecular_function +is_a: GO:0004985 ! opioid receptor activity + +[Term] +id: GO:0004989 +name: octopamine receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai, http://cancerweb.ncl.ac.uk/] +is_a: GO:0008227 ! amine receptor activity + +[Term] +id: GO:0004990 +name: oxytocin receptor activity +namespace: molecular_function +def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0004991 +name: parathyroid hormone receptor activity +namespace: molecular_function +def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004992 +name: platelet activating factor receptor activity +namespace: molecular_function +def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] +synonym: "PAF receptor activity" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004993 +name: serotonin receptor activity +namespace: molecular_function +alt_id: GO:0001585 +def: "Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "5-HT receptor" EXACT [] +synonym: "5-hydroxytryptamine receptor" EXACT [] +is_a: GO:0008227 ! amine receptor activity + +[Term] +id: GO:0004994 +name: somatostatin receptor activity +namespace: molecular_function +def: "Combining with somatostatin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004995 +name: tachykinin receptor activity +namespace: molecular_function +def: "Combining with tachykinin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004996 +name: thyroid-stimulating hormone receptor activity +namespace: molecular_function +def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] +synonym: "thyrotropin receptor" EXACT [] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004997 +name: thyrotropin-releasing hormone receptor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0004998 +name: transferrin receptor activity +namespace: molecular_function +def: "Combining with transferrin to initiate a change in cell activity." [GOC:mah] +subset: gosubset_prok +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0004999 +name: vasoactive intestinal polypeptide receptor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0005000 +name: vasopressin receptor activity +namespace: molecular_function +def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0005001 +name: transmembrane receptor protein tyrosine phosphatase activity +namespace: molecular_function +is_a: GO:0004725 ! protein tyrosine phosphatase activity +is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity + +[Term] +id: GO:0005003 +name: ephrin receptor activity +namespace: molecular_function +def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah] +synonym: "Eph receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005004 +name: GPI-linked ephrin receptor activity +namespace: molecular_function +synonym: "GPI-linked Eph receptor activity" EXACT [] +is_a: GO:0005003 ! ephrin receptor activity + +[Term] +id: GO:0005005 +name: transmembrane-ephrin receptor activity +namespace: molecular_function +synonym: "transmembrane-Eph receptor activity" EXACT [] +is_a: GO:0005003 ! ephrin receptor activity + +[Term] +id: GO:0005006 +name: epidermal growth factor receptor activity +namespace: molecular_function +alt_id: GO:0005023 +def: "Combining with an epidermal growth factor to initiate a change in cell activity." [GOC:bf] +subset: gosubset_prok +synonym: "EGF receptor activity" EXACT [] +synonym: "EGFR" EXACT [] +synonym: "TGF-alpha receptor activity" EXACT [] +synonym: "transforming growth factor-alpha receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005007 +name: fibroblast growth factor receptor activity +namespace: molecular_function +def: "Combining with fibroblast growth factor to initiate a change in cell activity." [GOC:mah] +synonym: "FGF receptor activity" EXACT [] +synonym: "FGFR" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005008 +name: hepatocyte growth factor receptor activity +namespace: molecular_function +def: "Combining with hepatocye growth factor to initiate a change in cell activity." [GOC:mah] +synonym: "HGF receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005009 +name: insulin receptor activity +namespace: molecular_function +def: "Combining with insulin to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005010 +name: insulin-like growth factor receptor activity +namespace: molecular_function +synonym: "IGF receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005011 +name: macrophage colony stimulating factor receptor activity +namespace: molecular_function +def: "Combining with macrophage colony stimulating factor to initiate a change in cell activity." [GOC:mah] +synonym: "CSF-1" NARROW [] +synonym: "Fms" NARROW [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005012 +name: Neu/ErbB-2 receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a class of receptor rather than an activity. +is_obsolete: true +consider: GO:0043125 + +[Term] +id: GO:0005013 +name: neurotrophin TRK receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0019838 +consider: GO:0043121 + +[Term] +id: GO:0005014 +name: neurotrophin TRKA receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0048404 +consider: GO:0048406 + +[Term] +id: GO:0005015 +name: neurotrophin TRKB receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0048403 +consider: GO:0048404 +consider: GO:0048405 + +[Term] +id: GO:0005016 +name: neurotrophin TRKC receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0048404 + +[Term] +id: GO:0005017 +name: platelet-derived growth factor receptor activity +namespace: molecular_function +def: "Combining with platelet-derived growth factor to initiate a change in cell activity." [GOC:mah] +synonym: "PDGF receptor activity" EXACT [] +synonym: "PDGFR activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005018 +name: platelet-derived growth factor alpha-receptor activity +namespace: molecular_function +synonym: "PDGF alpha-receptor activity" EXACT [] +is_a: GO:0005017 ! platelet-derived growth factor receptor activity + +[Term] +id: GO:0005019 +name: platelet-derived growth factor beta-receptor activity +namespace: molecular_function +synonym: "PDGF beta-receptor activity" EXACT [] +is_a: GO:0005017 ! platelet-derived growth factor receptor activity + +[Term] +id: GO:0005020 +name: stem cell factor receptor activity +namespace: molecular_function +def: "Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity." [GOC:jl, PMID:10698217] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005021 +name: vascular endothelial growth factor receptor activity +namespace: molecular_function +def: "Combining with vascular endothelial growth factor to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005024 +name: transforming growth factor beta receptor activity +namespace: molecular_function +def: "Combining with transforming growth factor beta to initiate a change in cell activity." [GOC:mah] +synonym: "TGF-beta receptor activity" EXACT [] +synonym: "TGFbeta receptor activity" EXACT [] +synonym: "TGFbetaR" EXACT [] +is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity + +[Term] +id: GO:0005025 +name: transforming growth factor beta receptor activity, type I +namespace: molecular_function +def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity." [GOC:mah, Reactome:REACT_6945.1] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "type I TGF-beta receptor activity" EXACT [] +synonym: "type I TGFbeta receptor activity" EXACT [] +synonym: "type I transforming growth factor beta receptor activity" EXACT [] +is_a: GO:0005024 ! transforming growth factor beta receptor activity + +[Term] +id: GO:0005026 +name: transforming growth factor beta receptor activity, type II +namespace: molecular_function +def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:REACT_6872.1] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +synonym: "type II TGF-beta receptor activity" EXACT [] +synonym: "type II TGFbeta receptor activity" EXACT [] +synonym: "type II transforming growth factor beta receptor activity" EXACT [] +xref: Reactome:11166 +is_a: GO:0005024 ! transforming growth factor beta receptor activity + +[Term] +id: GO:0005027 +name: NGF/TNF (6 C-domain) receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a protein family rather than a molecular function. +is_obsolete: true +consider: GO:0005031 + +[Term] +id: GO:0005028 +name: CD40 receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes the receptor type, and not an activity. +is_obsolete: true +consider: GO:0042615 + +[Term] +id: GO:0005029 +name: CD27 receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes the receptor type, and not an activity. +is_obsolete: true +consider: GO:0042614 + +[Term] +id: GO:0005030 +name: neurotrophin receptor activity +namespace: molecular_function +def: "Combining with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth, to initiate a change in cell activity." [GOC:jl, http://www.mercksource.com/] +is_a: GO:0004872 ! receptor activity +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0005031 +name: tumor necrosis factor receptor activity +namespace: molecular_function +alt_id: GO:0005032 +alt_id: GO:0005033 +def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] +synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] +synonym: "TNF receptor activity" EXACT [] +synonym: "TNF receptor activity, type I" NARROW [] +synonym: "TNF receptor activity, type II" NARROW [] +synonym: "tumor necrosis factor receptor activity, type I" NARROW [] +synonym: "tumor necrosis factor receptor activity, type II" NARROW [] +is_a: GO:0005035 ! death receptor activity +is_a: GO:0043120 ! tumor necrosis factor binding + +[Term] +id: GO:0005034 +name: osmosensor activity +namespace: molecular_function +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005035 +name: death receptor activity +namespace: molecular_function +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005037 +name: death receptor adaptor protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005123 +consider: GO:0005515 + +[Term] +id: GO:0005038 +name: death receptor interacting protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005123 +consider: GO:0005515 + +[Term] +id: GO:0005039 +name: death receptor-associated factor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005123 +consider: GO:0005515 + +[Term] +id: GO:0005040 +name: decoy death receptor activity +namespace: molecular_function +is_a: GO:0005035 ! death receptor activity + +[Term] +id: GO:0005041 +name: low-density lipoprotein receptor activity +namespace: molecular_function +alt_id: GO:0008032 +def: "Combining with a low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "LDL receptor" EXACT [] +is_a: GO:0030169 ! low-density lipoprotein binding +is_a: GO:0030228 ! lipoprotein receptor activity + +[Term] +id: GO:0005042 +name: netrin receptor activity +namespace: molecular_function +def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated." [GOC:dph] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005043 +name: repulsive netrin receptor activity +namespace: molecular_function +def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated." [GOC:dph] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005044 +name: scavenger receptor activity +namespace: molecular_function +def: "Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity." [PMID:11790542, PMID:12379907, PMID:12621157] +comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. +subset: gosubset_prok +synonym: "macrophage receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005045 +name: endoplasmic reticulum receptor activity +namespace: molecular_function +def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai] +comment: This term was made obsolete because it represents cellular component and molecular function information. +is_obsolete: true +replaced_by: GO:0004872 +replaced_by: GO:0005783 + +[Term] +id: GO:0005046 +name: KDEL sequence binding +namespace: molecular_function +def: "Interacting selectively with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] +synonym: "KDEL receptor activity" NARROW [] +is_a: GO:0046923 ! ER retention sequence binding + +[Term] +id: GO:0005047 +name: signal recognition particle binding +namespace: molecular_function +def: "Interacting selectively with the signal recognition particle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. +subset: gosubset_prok +synonym: "docking protein" BROAD [] +synonym: "signal recognition particle receptor" NARROW [] +is_a: GO:0043021 ! ribonucleoprotein binding + +[Term] +id: GO:0005048 +name: signal sequence binding +namespace: molecular_function +alt_id: GO:0008249 +def: "Interacting selectively with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] +subset: gosubset_prok +synonym: "leader sequence binding" NARROW [] +synonym: "protein signal sequence binding" NARROW [] +synonym: "signal sequence receptor" NARROW [] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0005049 +name: nuclear export signal receptor activity +namespace: molecular_function +def: "Combining with a nuclear export signal to initiate a change in cell activity." [GOC:ai] +synonym: "NES receptor" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005050 +name: peroxisome receptor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular component. +is_obsolete: true +consider: GO:0004872 +consider: GO:0005777 + +[Term] +id: GO:0005052 +name: peroxisome matrix targeting signal-1 binding +namespace: molecular_function +def: "Interacting selectively with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] +synonym: "peroxisome targeting signal-1 binding" EXACT [] +synonym: "peroxisome targeting signal-1 receptor" NARROW [] +synonym: "PEX5" NARROW [] +synonym: "PTS1 receptor" NARROW [] +is_a: GO:0000268 ! peroxisome targeting sequence binding + +[Term] +id: GO:0005053 +name: peroxisome matrix targeting signal-2 binding +namespace: molecular_function +def: "Interacting selectively with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] +synonym: "peroxisome targeting signal-2 binding" EXACT [] +synonym: "peroxisome targeting signal-2 receptor" NARROW [] +synonym: "PEX7" NARROW [] +synonym: "PTS2 receptor" EXACT [] +is_a: GO:0000268 ! peroxisome targeting sequence binding + +[Term] +id: GO:0005054 +name: peroxisome integral membrane receptor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular component. +synonym: "Pas20p" RELATED [] +is_obsolete: true +consider: GO:0004872 +consider: GO:0005778 + +[Term] +id: GO:0005055 +name: laminin receptor activity +namespace: molecular_function +def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. +subset: gosubset_prok +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005056 +name: tiggrin receptor activity +namespace: molecular_function +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0005057 +name: receptor signaling protein activity +namespace: molecular_function +synonym: "receptor signalling protein activity" EXACT [] +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0005061 +name: aryl hydrocarbon receptor nuclear translocator activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0005062 +name: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity +namespace: molecular_function +synonym: "gp130" NARROW [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0005065 +name: heterotrimeric G-protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a cellular component and not a molecular function. +is_obsolete: true +replaced_by: GO:0005834 + +[Term] +id: GO:0005066 +name: transmembrane receptor protein tyrosine kinase signaling protein activity +namespace: molecular_function +synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0005068 +name: transmembrane receptor protein tyrosine kinase adaptor protein activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a transmembrane receptor protein kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +is_a: GO:0005066 ! transmembrane receptor protein tyrosine kinase signaling protein activity +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0005069 +name: transmembrane receptor protein tyrosine kinase docking protein activity +namespace: molecular_function +is_a: GO:0005066 ! transmembrane receptor protein tyrosine kinase signaling protein activity + +[Term] +id: GO:0005070 +name: SH3/SH2 adaptor activity +namespace: molecular_function +def: "Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] +synonym: "SH3/SH2 adaptor protein activity" NARROW [] +is_a: GO:0004871 ! signal transducer activity +is_a: GO:0030674 ! protein binding, bridging +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0005071 +name: transmembrane receptor protein serine/threonine kinase signaling protein activity +namespace: molecular_function +synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0005072 +name: transforming growth factor beta receptor, cytoplasmic mediator activity +namespace: molecular_function +def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd] +comment: Note that this term and its children are useful for annotating proteins of the SMAD family. +synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] +is_a: GO:0005071 ! transmembrane receptor protein serine/threonine kinase signaling protein activity + +[Term] +id: GO:0005073 +name: common-partner SMAD protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it names a family of gene products. +is_obsolete: true +replaced_by: GO:0030616 + +[Term] +id: GO:0005074 +name: inhibitory SMAD protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it names a family of gene products. +is_obsolete: true +replaced_by: GO:0030617 + +[Term] +id: GO:0005075 +name: pathway-specific SMAD protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a family of gene products. +is_obsolete: true +replaced_by: GO:0030618 + +[Term] +id: GO:0005076 +name: receptor signaling protein serine/threonine kinase signaling protein activity +namespace: molecular_function +synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0005077 +name: MAP-kinase anchoring activity +namespace: molecular_function +def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai] +comment: This term was made obsolete because it represents a combination of process and function information. +synonym: "MAP-kinase anchor protein activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008104 +replaced_by: GO:0051019 + +[Term] +id: GO:0005078 +name: MAP-kinase scaffold activity +namespace: molecular_function +def: "Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins." [PMID:12511654] +synonym: "MAP-kinase scaffold protein activity" EXACT [] +is_a: GO:0030159 ! receptor signaling complex scaffold activity + +[Term] +id: GO:0005079 +name: protein kinase A anchoring activity +namespace: molecular_function +def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567] +comment: This term was made obsolete because it represents a combination of process and function information. +synonym: "A-kinase anchor protein activity" EXACT [] +synonym: "AKAP activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008104 +replaced_by: GO:0051018 + +[Term] +id: GO:0005080 +name: protein kinase C binding +namespace: molecular_function +def: "Interacting selectively with protein kinase C." [GOC:jl] +synonym: "PKC binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0005081 +name: receptor signaling protein serine/threonine phosphatase signaling protein activity +namespace: molecular_function +synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0005082 +name: receptor signaling protein tyrosine phosphatase signaling protein activity +namespace: molecular_function +synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0005083 +name: small GTPase regulator activity +namespace: molecular_function +def: "Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah] +subset: gosubset_prok +synonym: "small GTPase regulatory/interacting protein activity" RELATED [] +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005085 +name: guanyl-nucleotide exchange factor activity +namespace: molecular_function +alt_id: GO:0008433 +alt_id: GO:0019839 +def: "Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] +subset: gosubset_prok +synonym: "GEF" EXACT [] +synonym: "GNRP" NARROW [] +synonym: "guanyl-nucleotide release factor activity" EXACT [] +synonym: "guanyl-nucleotide releasing factor" EXACT [] +xref: Reactome:11431 +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005086 +name: ARF guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0005087 +name: Ran guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +synonym: "RCC1" EXACT [] +xref: Reactome:11435 +is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0005088 +name: Ras guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +xref: Reactome:11436 +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0005089 +name: Rho guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +synonym: "Rho guanine nucleotide exchange factor" EXACT [] +synonym: "RhoGEF" EXACT [] +is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0005090 +name: Sar guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by the GTPase Sar. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0005091 +name: guanyl-nucleotide exchange factor adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0005092 +name: GDP-dissociation inhibitor activity +namespace: molecular_function +def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] +synonym: "GDI" EXACT [] +is_a: GO:0005083 ! small GTPase regulator activity + +[Term] +id: GO:0005093 +name: Rab GDP-dissociation inhibitor activity +namespace: molecular_function +def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] +is_a: GO:0005092 ! GDP-dissociation inhibitor activity + +[Term] +id: GO:0005094 +name: Rho GDP-dissociation inhibitor activity +namespace: molecular_function +def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] +is_a: GO:0005092 ! GDP-dissociation inhibitor activity + +[Term] +id: GO:0005095 +name: GTPase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] +synonym: "GIP" BROAD [] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005096 +name: GTPase activator activity +namespace: molecular_function +def: "Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] +subset: gosubset_prok +synonym: "GAP activity" EXACT [] +xref: Reactome:11473 +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005097 +name: Rab GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah] +is_a: GO:0005099 ! Ras GTPase activator activity + +[Term] +id: GO:0005098 +name: Ran GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [GOC:mah] +synonym: "RanGAP" RELATED [] +is_a: GO:0005099 ! Ras GTPase activator activity + +[Term] +id: GO:0005099 +name: Ras GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [GOC:mah] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0005096 ! GTPase activator activity + +[Term] +id: GO:0005100 +name: Rho GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Rho family." [GOC:mah] +is_a: GO:0005099 ! Ras GTPase activator activity + +[Term] +id: GO:0005101 +name: Sar GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by the GTPase Sar." [GOC:mah] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0005096 ! GTPase activator activity + +[Term] +id: GO:0005102 +name: receptor binding +namespace: molecular_function +def: "Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +synonym: "receptor ligand" NARROW [] +synonym: "receptor-associated protein activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005104 +name: fibroblast growth factor receptor binding +namespace: molecular_function +alt_id: GO:0001521 +alt_id: GO:0005162 +def: "Interacting selectively with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] +comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. +synonym: "FGF receptor binding" EXACT [] +synonym: "FGFR binding" EXACT [] +synonym: "FGFR ligand" NARROW [] +synonym: "fibroblast growth factor" BROAD [] +synonym: "fibroblast growth factor receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005105 +name: type 1 fibroblast growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] +comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). +synonym: "breathless binding" NARROW [] +synonym: "breathless ligand" NARROW [] +synonym: "FGFR1 binding" BROAD [] +synonym: "FGFR1 ligand" NARROW [] +synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] +is_a: GO:0005104 ! fibroblast growth factor receptor binding + +[Term] +id: GO:0005106 +name: ephrin +namespace: molecular_function +def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +consider: GO:0046875 + +[Term] +id: GO:0005107 +name: GPI-linked ephrin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +consider: GO:0046658 +consider: GO:0046875 + +[Term] +id: GO:0005108 +name: transmembrane ephrin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +consider: GO:0005887 +consider: GO:0046875 + +[Term] +id: GO:0005109 +name: frizzled binding +namespace: molecular_function +def: "Interacting selectively with the frizzled (fz) receptor." [GOC:ceb] +synonym: "frizzled ligand" NARROW [] +synonym: "fz binding" EXACT [] +synonym: "fz ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0005110 +name: frizzled-2 binding +namespace: molecular_function +def: "Interacting selectively with frizzled-2 (fz2)." [GOC:ceb] +synonym: "frizzled-2 ligand" NARROW [] +synonym: "fz2 binding" EXACT [] +synonym: "fz2 ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0005111 +name: type 2 fibroblast growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] +comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). +synonym: "FGFR2 binding" EXACT [] +synonym: "FGFR2 ligand" NARROW [] +synonym: "heartless binding" EXACT [] +synonym: "heartless ligand" NARROW [] +synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] +is_a: GO:0005104 ! fibroblast growth factor receptor binding + +[Term] +id: GO:0005112 +name: Notch binding +namespace: molecular_function +def: "Interacting selectively with the Notch (N) protein, a surface receptor." [GOC:ceb] +synonym: "N binding" EXACT [] +synonym: "N ligand" NARROW [] +synonym: "Notch ligand" NARROW [] +synonym: "Notch receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005113 +name: patched binding +namespace: molecular_function +def: "Interacting selectively with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] +synonym: "patched ligand" NARROW [] +synonym: "ptc binding" EXACT [] +synonym: "ptc ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005114 +name: type II transforming growth factor beta receptor binding +namespace: molecular_function +def: "Interacting selectively with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892] +synonym: "punt binding" NARROW [] +synonym: "punt ligand" NARROW [] +synonym: "TGF-beta type II binding" EXACT [] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +synonym: "transforming growth factor beta receptor type II binding" EXACT [] +synonym: "type II TGF-beta binding" EXACT [] +is_a: GO:0005160 ! transforming growth factor beta receptor binding + +[Term] +id: GO:0005115 +name: receptor tyrosine kinase-like orphan receptor binding +namespace: molecular_function +def: "Interaction with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb] +synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] +synonym: "Ror binding" BROAD [] +synonym: "Ror ligand" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005117 +name: wishful thinking binding +namespace: molecular_function +def: "Interacting selectively with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] +synonym: "SE20 receptor binding" NARROW [] +synonym: "wishful thinking ligand" NARROW [] +synonym: "Wit binding" EXACT [] +synonym: "Wit ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005118 +name: sevenless binding +namespace: molecular_function +def: "Interacting selectively with the sevenless (sev) protein, a receptor tyrosine kinase." [FB:gn0003366, GOC:ceb] +synonym: "sev binding" EXACT [] +synonym: "sev ligand" NARROW [] +synonym: "sevenless ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005119 +name: smoothened binding +namespace: molecular_function +def: "Interacting selectively with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] +synonym: "smo binding" EXACT [] +synonym: "smo ligand" NARROW [] +synonym: "smoothened ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005121 +name: Toll binding +namespace: molecular_function +def: "Interacting selectively with the Toll protein, a transmembrane receptor." [GOC:ceb] +synonym: "Tl binding" EXACT [] +synonym: "Toll ligand" NARROW [] +synonym: "Toll receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005122 +name: torso binding +namespace: molecular_function +def: "Interacting selectively with the torso (tor) protein, a receptor tyrosine kinase." [FB:gn0003733, GOC:ceb] +synonym: "tor binding" EXACT [] +synonym: "tor ligand" NARROW [] +synonym: "torso ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005123 +name: death receptor binding +namespace: molecular_function +def: "Interacting selectively with a death receptor." [GOC:ceb] +synonym: "death receptor adaptor protein activity" RELATED [] +synonym: "death receptor interacting protein activity" RELATED [] +synonym: "death receptor ligand" NARROW [] +synonym: "death receptor-associated factor activity" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005124 +name: scavenger receptor binding +namespace: molecular_function +def: "Interacting selectively with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] +synonym: "scavenger receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005125 +name: cytokine activity +namespace: molecular_function +def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005126 +name: hematopoietin/interferon-class (D200-domain) cytokine receptor binding +namespace: molecular_function +synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005127 +name: ciliary neurotrophic factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the ciliary neurotrophic factor receptor." [GOC:ai] +synonym: "ciliary neurotrophic factor" NARROW [] +synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005128 +name: erythropoietin receptor binding +namespace: molecular_function +def: "Interacting selectively with the erythropoietin receptor." [GOC:ai] +synonym: "erythropoietin" NARROW [] +synonym: "erythropoietin receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005129 +name: granulocyte macrophage colony-stimulating factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] +synonym: "GM-CSF receptor ligand" NARROW [] +synonym: "GMC-SF receptor ligand" NARROW [] +synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] +synonym: "granulocyte-macrophage colony stimulating factor" NARROW [] +is_a: GO:0005128 ! erythropoietin receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005130 +name: granulocyte colony-stimulating factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the granulocyte colony-stimulating factor receptor." [GOC:ai] +synonym: "G-CSF receptor ligand" EXACT [] +synonym: "GC-SF receptor ligand" EXACT [] +synonym: "granulocyte colony-stimulating factor" NARROW [] +synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005131 +name: growth hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with the growth hormone receptor." [GOC:ai] +synonym: "growth hormone" NARROW [] +synonym: "growth hormone receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005132 +name: interferon-alpha/beta receptor binding +namespace: molecular_function +def: "Interacting selectively with the interferon-alpha/beta receptor." [GOC:ai] +synonym: "interferon-alpha/beta" NARROW [] +synonym: "interferon-alpha/beta receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005133 +name: interferon-gamma receptor binding +namespace: molecular_function +def: "Interacting selectively with the interferon-gamma receptor." [GOC:ai] +synonym: "interferon-gamma" NARROW [] +synonym: "interferon-gamma receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005134 +name: interleukin-2 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-2 receptor." [GOC:ai] +synonym: "IL-2" NARROW [] +synonym: "interleukin-2 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005135 +name: interleukin-3 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-3 receptor." [GOC:ai] +synonym: "IL-3" NARROW [] +synonym: "interleukin-3 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005136 +name: interleukin-4 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-4 receptor." [GOC:ai] +synonym: "IL-4" NARROW [] +synonym: "interleukin-4 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005137 +name: interleukin-5 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-5 receptor." [GOC:ai] +synonym: "IL-5" NARROW [] +synonym: "interleukin-5 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005138 +name: interleukin-6 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-6 receptor." [GOC:ai] +synonym: "IL-6" NARROW [] +synonym: "interleukin-6 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005139 +name: interleukin-7 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-7 receptor." [GOC:ai] +synonym: "IL-7" NARROW [] +synonym: "interleukin-7 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005140 +name: interleukin-9 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-9 receptor." [GOC:ai] +synonym: "IL-9" NARROW [] +synonym: "interleukin-9 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005141 +name: interleukin-10 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-10 receptor." [GOC:ai] +synonym: "IL-10" NARROW [] +synonym: "interleukin-10 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005142 +name: interleukin-11 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-11 receptor." [GOC:ai] +synonym: "IL-11" NARROW [] +synonym: "interleukin-11 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005143 +name: interleukin-12 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-12 receptor." [GOC:ai] +synonym: "IL-12" NARROW [] +synonym: "interleukin-12 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005144 +name: interleukin-13 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-13 receptor." [GOC:ai] +synonym: "IL-13" NARROW [] +synonym: "interleukin-13 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005145 +name: interleukin-14 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-14 receptor." [GOC:ai] +synonym: "IL-14" NARROW [] +synonym: "interleukin-14 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005146 +name: leukemia inhibitory factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the leukemia inhibitory factor receptor." [GOC:ai] +synonym: "leukemia inhibitory factor" NARROW [] +synonym: "leukemia inhibitory factor receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005147 +name: oncostatin-M receptor binding +namespace: molecular_function +def: "Interacting selectively with the oncostatin-M receptor." [GOC:ai] +synonym: "oncostatin-M" NARROW [] +synonym: "oncostatin-M receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005148 +name: prolactin receptor binding +namespace: molecular_function +def: "Interacting selectively with the prolactin receptor." [GOC:ai] +synonym: "prolactin" NARROW [] +synonym: "prolactin receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0005149 +name: interleukin-1 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-1 receptor." [GOC:go_curators] +synonym: "IL-1" NARROW [] +synonym: "interleukin-1 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005150 +name: interleukin-1, Type I receptor binding +namespace: molecular_function +def: "Interacting selectively with a Type I interleukin-1 receptor." [GOC:ai] +synonym: "IL-1 type I" NARROW [] +synonym: "interleukin-1, Type I receptor ligand" NARROW [] +is_a: GO:0005149 ! interleukin-1 receptor binding + +[Term] +id: GO:0005151 +name: interleukin-1, Type II receptor binding +namespace: molecular_function +def: "Interacting selectively with a Type II interleukin-1 receptor." [GOC:ai] +synonym: "IL-1 type II" NARROW [] +synonym: "interleukin-1, Type II receptor ligand" NARROW [] +is_a: GO:0005149 ! interleukin-1 receptor binding + +[Term] +id: GO:0005152 +name: interleukin-1 receptor antagonist activity +namespace: molecular_function +def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] +synonym: "IL-1ra" EXACT [] +is_a: GO:0005149 ! interleukin-1 receptor binding +is_a: GO:0030353 ! fibroblast growth factor receptor antagonist activity + +[Term] +id: GO:0005153 +name: interleukin-8 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-8 receptor." [GOC:go_curators] +synonym: "IL-8" NARROW [] +synonym: "interleukin-8 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005154 +name: epidermal growth factor receptor binding +namespace: molecular_function +alt_id: GO:0008185 +def: "Interacting selectively with the epidermal growth factor receptor." [GOC:ai] +synonym: "EGF" NARROW [] +synonym: "EGF receptor binding" EXACT [] +synonym: "EGF receptor ligand" NARROW [] +synonym: "EGFR binding" EXACT [] +synonym: "epidermal growth factor" NARROW [] +synonym: "epidermal growth factor receptor ligand" NARROW [] +synonym: "TGF-alpha receptor binding" EXACT [] +synonym: "TGFalpha receptor binding" EXACT [] +synonym: "transforming growth factor alpha" NARROW [] +synonym: "transforming growth factor alpha receptor binding" EXACT [] +synonym: "transforming growth factor alpha receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005155 +name: epidermal growth factor receptor activating ligand activity +namespace: molecular_function +synonym: "EGF receptor activating ligand activity" EXACT [] +synonym: "EGFR activating ligand activity" EXACT [] +is_a: GO:0005154 ! epidermal growth factor receptor binding + +[Term] +id: GO:0005156 +name: epidermal growth factor receptor inhibiting ligand activity +namespace: molecular_function +synonym: "EGF receptor inhibiting ligand activity" EXACT [] +synonym: "EGFR inhibiting ligand activity" EXACT [] +is_a: GO:0005154 ! epidermal growth factor receptor binding + +[Term] +id: GO:0005157 +name: macrophage colony stimulating factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the macrophage colony stimulating factor receptor." [GOC:ai] +synonym: "macrophage colony stimulating factor receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0005158 +name: insulin receptor binding +namespace: molecular_function +def: "Interacting selectively with the insulin receptor." [GOC:ai] +synonym: "insulin receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0005159 +name: insulin-like growth factor receptor binding +namespace: molecular_function +alt_id: GO:0005067 +def: "Interacting selectively with the insulin-like growth factor receptor." [GOC:jl] +synonym: "IGF receptor binding" EXACT [] +synonym: "insulin-like growth factor" NARROW [] +synonym: "insulin-like growth factor receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005160 +name: transforming growth factor beta receptor binding +namespace: molecular_function +def: "Interacting selectively with the transforming growth factor beta receptor." [GOC:ai] +synonym: "activin" RELATED [] +synonym: "inhibin" RELATED [] +synonym: "TGF-beta receptor binding" EXACT [] +synonym: "TGFbeta receptor binding" EXACT [] +synonym: "transforming growth factor beta" NARROW [] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] +synonym: "transforming growth factor beta receptor ligand" NARROW [] +xref: Reactome:4078 +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005161 +name: platelet-derived growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the platelet-derived growth factor receptor." [GOC:ai] +synonym: "PDGF" NARROW [] +synonym: "PDGF receptor binding" EXACT [] +synonym: "PDGFR binding" EXACT [] +synonym: "platelet-derived growth factor" NARROW [] +synonym: "platelet-derived growth factor receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005163 +name: nerve growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the nerve growth factor receptor." [GOC:ai] +synonym: "nerve growth factor receptor ligand" NARROW [] +synonym: "neurotrophin" NARROW [] +synonym: "NGF receptor binding" EXACT [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0005164 +name: tumor necrosis factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the tumor necrosis factor receptor." [GOC:ai] +synonym: "TNF receptor binding" EXACT [] +synonym: "tumor necrosis factor" NARROW [] +synonym: "tumor necrosis factor receptor ligand" NARROW [] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005165 +name: neurotrophin receptor binding +namespace: molecular_function +def: "Interacting selectively with a neurotrophin receptor." [GOC:ai] +synonym: "neurotrophin" NARROW [] +synonym: "neurotrophin receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005166 +name: neurotrophin p75 receptor binding +namespace: molecular_function +def: "Interacting selectively with the neurotrophin p75 receptor." [GOC:ai] +synonym: "neurotrophin p75 receptor ligand" NARROW [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0005167 +name: neurotrophin TRK receptor binding +namespace: molecular_function +def: "Interacting selectively with a neurotrophin TRK receptor." [GOC:ai] +synonym: "neurotrophin TRK receptor ligand" NARROW [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0005168 +name: neurotrophin TRKA receptor binding +namespace: molecular_function +def: "Interacting selectively with the neurotrophin TRKA receptor." [GOC:ai] +synonym: "neurotrophin TRKA receptor ligand" NARROW [] +is_a: GO:0005167 ! neurotrophin TRK receptor binding + +[Term] +id: GO:0005169 +name: neurotrophin TRKB receptor binding +namespace: molecular_function +def: "Interacting selectively with the neurotrophin TRKB receptor." [GOC:ai] +synonym: "neurotrophin TRKB receptor ligand" NARROW [] +is_a: GO:0005167 ! neurotrophin TRK receptor binding + +[Term] +id: GO:0005170 +name: neurotrophin TRKC receptor binding +namespace: molecular_function +def: "Interacting selectively with the neurotrophin TRKC receptor." [GOC:ai] +synonym: "neurotrophin TRKC receptor ligand" NARROW [] +is_a: GO:0005167 ! neurotrophin TRK receptor binding + +[Term] +id: GO:0005171 +name: hepatocyte growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the hepatocyte growth factor receptor." [GOC:ai] +synonym: "hepatocyte growth factor" NARROW [] +synonym: "hepatocyte growth factor receptor ligand" NARROW [] +synonym: "HGF receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005172 +name: vascular endothelial growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with any vascular endothelial growth factor receptor." [GOC:ai] +synonym: "vascular endothelial growth factor" NARROW [] +synonym: "vascular endothelial growth factor receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005173 +name: stem cell factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] +synonym: "KIT binding" NARROW [] +synonym: "SCF" NARROW [] +synonym: "SCFR binding" EXACT [] +synonym: "stem cell factor" NARROW [] +synonym: "stem cell factor receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005174 +name: CD40 receptor binding +namespace: molecular_function +def: "Interacting selectively with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005175 +name: CD27 receptor binding +namespace: molecular_function +def: "Interacting selectively with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005176 +name: ErbB-2 class receptor binding +namespace: molecular_function +def: "Interacting selectively with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] +synonym: "ErbB-2 class receptor ligand" NARROW [] +synonym: "HER2 receptor binding" EXACT [] +synonym: "HER2 receptor ligand" NARROW [] +synonym: "Neu receptor binding" EXACT [] +synonym: "Neu receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005177 +name: neuroligin +namespace: molecular_function +def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai] +is_obsolete: true +consider: GO:0042043 + +[Term] +id: GO:0005178 +name: integrin binding +namespace: molecular_function +def: "Interacting selectively with an integrin." [GOC:ceb] +synonym: "integrin ligand" NARROW [] +is_a: GO:0005102 ! receptor binding +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0005179 +name: hormone activity +namespace: molecular_function +def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "cAMP generating peptide activity" NARROW [] +synonym: "glycopeptide hormone" NARROW [] +synonym: "lipopeptide hormone" NARROW [] +synonym: "peptide hormone" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005180 +name: peptide hormone +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. +is_obsolete: true +consider: GO:0005179 + +[Term] +id: GO:0005181 +name: glycopeptide hormone +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. +is_obsolete: true +consider: GO:0005179 + +[Term] +id: GO:0005182 +name: lipopeptide hormone +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. +is_obsolete: true +consider: GO:0005179 + +[Term] +id: GO:0005183 +name: luteinizing hormone-releasing factor activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0005184 +name: neuropeptide hormone activity +namespace: molecular_function +def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] +synonym: "neurohormone" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0005185 +name: neurohypophyseal hormone activity +namespace: molecular_function +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0005186 +name: pheromone activity +namespace: molecular_function +def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0005187 +name: storage protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular location rather than a function. +is_obsolete: true +replaced_by: GO:0045735 + +[Term] +id: GO:0005188 +name: larval serum protein (sensu Insecta) +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "arylphorin" NARROW [] +is_obsolete: true + +[Term] +id: GO:0005189 +name: milk protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005190 +name: seminal fluid protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005191 +name: acidic epididymal glycoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005192 +name: urinary protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005193 +name: major urinary protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005194 +name: cell adhesion molecule activity +namespace: molecular_function +def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0030246 +consider: GO:0050839 + +[Term] +id: GO:0005198 +name: structural molecule activity +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005199 +name: structural constituent of cell wall +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] +subset: gosubset_prok +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005200 +name: structural constituent of cytoskeleton +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] +subset: gosubset_prok +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005201 +name: extracellular matrix structural constituent +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] +subset: gosubset_prok +synonym: "extracellular matrix glycoprotein" NARROW [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005202 +name: collagen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0005581 + +[Term] +id: GO:0005203 +name: proteoglycan +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. +is_obsolete: true + +[Term] +id: GO:0005204 +name: chondroitin sulfate proteoglycan +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. +synonym: "chondroitin sulphate proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005205 +name: chondroitin sulfate/dermatan sulfate proteoglycan +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. +synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005206 +name: heparin sulfate proteoglycan +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "heparin sulphate proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005207 +name: extracellular matrix glycoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes localization and modification rather than activity. +is_obsolete: true +consider: GO:0005201 + +[Term] +id: GO:0005208 +name: amyloid protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0005209 +name: plasma protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005211 +name: plasma glycoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. +is_obsolete: true + +[Term] +id: GO:0005212 +name: structural constituent of eye lens +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005213 +name: structural constituent of chorion +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a chorion." [GOC:mah, GOC:sensu] +synonym: "structural constituent of chorion (sensu Insecta)" EXACT [] +synonym: "structural protein of chorion (sensu Drosophila)" NARROW [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005214 +name: structural constituent of chitin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of cuticle (sensu Insecta)" EXACT [] +is_a: GO:0042302 ! structural constituent of cuticle + +[Term] +id: GO:0005215 +name: transporter activity +namespace: molecular_function +alt_id: GO:0005478 +def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai, GOC:df] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "small-molecule carrier or transporter" RELATED [] +xref: Reactome:1391 +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005216 +name: ion channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729] +subset: goslim_generic +subset: gosubset_prok +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022838 ! substrate specific channel activity + +[Term] +id: GO:0005217 +name: intracellular ligand-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0005218 +name: intracellular ligand-gated calcium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0005219 +name: ryanodine-sensitive calcium-release channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] +synonym: "caffeine-sensitive calcium-release channel" RELATED [] +synonym: "ryanodine receptor" NARROW [] +is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity + +[Term] +id: GO:0005220 +name: inositol 1,4,5-triphosphate-sensitive calcium-release channel activity +namespace: molecular_function +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0005221 +name: intracellular cyclic nucleotide activated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0005261 ! cation channel activity +is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity + +[Term] +id: GO:0005222 +name: intracellular cAMP activated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] +synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] +synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] +synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] +synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] +is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity + +[Term] +id: GO:0005223 +name: intracellular cGMP activated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] +is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity + +[Term] +id: GO:0005224 +name: ATP-binding and phosphorylation-dependent chloride channel activity +namespace: molecular_function +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0005254 ! chloride channel activity + +[Term] +id: GO:0005225 +name: volume-sensitive anion channel activity +namespace: molecular_function +synonym: "volume-regulated channel" BROAD [] +is_a: GO:0005253 ! anion channel activity + +[Term] +id: GO:0005227 +name: calcium activated cation channel activity +namespace: molecular_function +def: "Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] +synonym: "intracellular calcium-activated potassium channel" NARROW [] +synonym: "polycystin" NARROW [] +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0005228 +name: intracellular sodium activated potassium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0005229 +name: intracellular calcium activated chloride channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0005230 +name: extracellular ligand-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0005231 +name: excitatory extracellular ligand-gated ion channel activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity + +[Term] +id: GO:0005232 +name: serotonin-activated cation-selective channel activity +namespace: molecular_function +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'serotonin receptor activity ; GO:0004993'. +synonym: "5-hydroxytryptamine-gated receptor-channel" EXACT [] +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0005234 +name: extracellular-glutamate-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. +subset: gosubset_prok +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity + +[Term] +id: GO:0005237 +name: inhibitory extracellular ligand-gated ion channel activity +namespace: molecular_function +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity + +[Term] +id: GO:0005240 +name: glycine receptor-associated protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not describe a molecular function. +is_obsolete: true +consider: GO:0005515 + +[Term] +id: GO:0005241 +name: inward rectifier channel +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +is_obsolete: true +consider: GO:0005242 + +[Term] +id: GO:0005242 +name: inward rectifier potassium channel activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0005243 +name: gap junction channel activity +namespace: molecular_function +alt_id: GO:0015285 +alt_id: GO:0015286 +def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] +synonym: "connexin" RELATED [] +synonym: "innexin" NARROW [] +synonym: "innexin channel activity" EXACT [] +synonym: "intercellular channel" BROAD [] +is_a: GO:0022829 ! wide pore channel activity + +[Term] +id: GO:0005244 +name: voltage-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "voltage gated ion channel activity" EXACT [] +synonym: "voltage-dependent ion channel activity" EXACT [] +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022832 ! voltage-gated channel activity + +[Term] +id: GO:0005245 +name: voltage-gated calcium channel activity +namespace: molecular_function +alt_id: GO:0010173 +def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] +synonym: "depolarization-activated calcium channel" BROAD [] +synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] +synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] +synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] +synonym: "voltage gated calcium channel activity" EXACT [] +synonym: "voltage-dependent calcium channel activity" EXACT [] +synonym: "voltage-gated calcium ion channel activity" EXACT [] +synonym: "voltage-sensitive calcium channel" EXACT [] +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0005246 +name: calcium channel regulator activity +namespace: molecular_function +is_a: GO:0016247 ! channel regulator activity + +[Term] +id: GO:0005247 +name: voltage-gated chloride channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "voltage gated chloride channel activity" EXACT [] +synonym: "voltage-dependent chloride channel activity" EXACT [] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0008308 ! voltage-gated anion channel activity + +[Term] +id: GO:0005248 +name: voltage-gated sodium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] +synonym: "voltage gated sodium channel activity" EXACT [] +synonym: "voltage-dependent sodium channel activity" EXACT [] +synonym: "voltage-gated sodium ion channel activity" EXACT [] +synonym: "voltage-sensitive sodium channel" EXACT [] +is_a: GO:0005272 ! sodium channel activity +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0005249 +name: voltage-gated potassium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "voltage gated potassium channel activity" EXACT [] +synonym: "voltage-dependent potassium channel activity" EXACT [] +synonym: "voltage-gated potassium ion channel activity" EXACT [] +synonym: "voltage-sensitive potassium channel" EXACT [] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0005250 +name: A-type (transient outward) potassium channel activity +namespace: molecular_function +is_a: GO:0015271 ! outward rectifier potassium channel activity + +[Term] +id: GO:0005251 +name: delayed rectifier potassium channel activity +namespace: molecular_function +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0005252 +name: open rectifier potassium channel activity +namespace: molecular_function +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0005253 +name: anion channel activity +namespace: molecular_function +def: "Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0005216 ! ion channel activity +is_a: GO:0008509 ! anion transmembrane transporter activity + +[Term] +id: GO:0005254 +name: chloride channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0005253 ! anion channel activity + +[Term] +id: GO:0005260 +name: channel-conductance-controlling ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49] +synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49] +synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] +synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49] +xref: EC:3.6.3.49 +xref: MetaCyc:3.6.3.49-RXN +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0005261 +name: cation channel activity +namespace: molecular_function +alt_id: GO:0015281 +alt_id: GO:0015338 +def: "Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "cation diffusion facilitator activity" EXACT [] +synonym: "nonselective cation channel activity" EXACT [] +is_a: GO:0005216 ! ion channel activity +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0005262 +name: calcium channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of a calcium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:13088 +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0005267 +name: potassium channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0005272 +name: sodium channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0005274 +name: allantoin uptake transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015206 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] +synonym: "allantoin permease activity" RELATED [] +synonym: "allantoin/allantoate transporter" BROAD [] +is_a: GO:0015391 ! nucleobase:cation symporter activity +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0005275 +name: amine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005279 +def: "Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "amine/amide/polyamine channel activity" BROAD [] +synonym: "amine/polyamine transmembrane transporter activity" EXACT [] +synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] +is_a: GO:0022804 ! active transmembrane transporter activity +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0005276 +name: hydrogen:vesicular amine antiporter activity +namespace: molecular_function +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0015299 ! solute:hydrogen antiporter activity + +[Term] +id: GO:0005277 +name: acetylcholine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0005326 ! neurotransmitter transporter activity + +[Term] +id: GO:0005278 +name: acetylcholine:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] +synonym: "acetylcholine:proton antiporter" EXACT [] +is_a: GO:0005277 ! acetylcholine transmembrane transporter activity +is_a: GO:0015299 ! solute:hydrogen antiporter activity + +[Term] +id: GO:0005280 +name: hydrogen:amino acid symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "cation/amino acid symporter" BROAD [] +is_a: GO:0005416 ! cation:amino acid symporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity + +[Term] +id: GO:0005281 +name: general amino acid permease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "general amino acid transporter" BROAD [] +is_obsolete: true +replaced_by: GO:0015171 + +[Term] +id: GO:0005283 +name: sodium:amino acid symporter activity +namespace: molecular_function +alt_id: GO:0005285 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] +synonym: "isoleucine/valine:sodium symporter activity" NARROW [] +synonym: "sodium/amino acid transporter" EXACT [] +synonym: "sodium/excitatory amino acid cotransporter activity" EXACT [] +synonym: "sodium/excitatory amino acid symporter activity" EXACT [] +synonym: "sodium:amino acid transporter activity" EXACT [] +synonym: "threonine/serine:sodium symporter activity" NARROW [] +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0005416 ! cation:amino acid symporter activity + +[Term] +id: GO:0005284 +name: insulin-activated sodium:amino acid symporter activity +namespace: molecular_function +synonym: "insulin-activated sodium/amino acid transporter activity" EXACT [] +synonym: "insulin-activated sodium:amino acid transporter activity" EXACT [] +is_a: GO:0005283 ! sodium:amino acid symporter activity + +[Term] +id: GO:0005287 +name: high affinity basic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high-affinity basic amino acid transporter activity" BROAD [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity + +[Term] +id: GO:0005289 +name: high affinity arginine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of arginine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high-affinity arginine transporter activity" BROAD [] +is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity +is_a: GO:0015181 ! arginine transmembrane transporter activity + +[Term] +id: GO:0005290 +name: L-histidine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] +synonym: "L-histidine transporter activity" BROAD [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0005291 +name: high affinity L-histidine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity histidine permease activity" RELATED [] +is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity +is_a: GO:0005290 ! L-histidine transmembrane transporter activity + +[Term] +id: GO:0005292 +name: high affinity lysine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of lysine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity lysine transporter activity" BROAD [] +is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity +is_a: GO:0015189 ! L-lysine transmembrane transporter activity + +[Term] +id: GO:0005294 +name: neutral L-amino acid secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +subset: gosubset_prok +synonym: "neutral L-amino acid porter activity" RELATED [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0005295 +name: neutral amino acid:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005282 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] +synonym: "neutral amino acid-sodium cotransporter" BROAD [] +synonym: "sodium/neutral amino acid transporter" BROAD [] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0005297 +name: hydrogen:proline symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] +synonym: "hydrogen/proline transporter" BROAD [] +is_a: GO:0005280 ! hydrogen:amino acid symporter activity +is_a: GO:0015193 ! L-proline transmembrane transporter activity + +[Term] +id: GO:0005298 +name: proline:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] +subset: gosubset_prok +synonym: "sodium/proline symporter" EXACT [] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0015193 ! L-proline transmembrane transporter activity + +[Term] +id: GO:0005300 +name: high-affinity tryptophan transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] +synonym: "high-affinity tryptophan transporter activity" BROAD [] +is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity + +[Term] +id: GO:0005301 +name: valine/tyrosine/tryptophan permease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT [] +is_obsolete: true +consider: GO:0005302 +consider: GO:0005304 +consider: GO:0015196 +consider: GO:0022857 + +[Term] +id: GO:0005302 +name: L-tyrosine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015508 +def: "Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-tyrosine permease activity" EXACT [] +synonym: "L-tyrosine transporter activity" BROAD [] +synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0005304 +name: L-valine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "isoleucine/valine:sodium symporter activity" NARROW [] +synonym: "L-valine transporter activity" BROAD [] +synonym: "leucine/isoleucine/valine porter activity" NARROW [] +synonym: "leucine/valine/isoleucine permease activity" NARROW [] +synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0005307 +name: choline:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] +synonym: "sodium/choline symporter" EXACT [] +is_a: GO:0015220 ! choline transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005308 +name: creatine transporter activity +namespace: molecular_function +def: "Enables the directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0005309 +name: creatine:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] +synonym: "sodium/chloride-dependent creatine transporter" BROAD [] +is_a: GO:0005308 ! creatine transporter activity +is_a: GO:0005328 ! neurotransmitter:sodium symporter activity + +[Term] +id: GO:0005310 +name: dicarboxylic acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005312 +alt_id: GO:0015365 +def: "Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] +subset: gosubset_prok +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] +synonym: "dicarboxylate carrier" NARROW [] +synonym: "dicarboxylic acid permease activity" RELATED [] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0005311 +name: sodium:dicarboxylate/tricarboxylate symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" EXACT [] +is_obsolete: true +consider: GO:0005310 +consider: GO:0005343 +consider: GO:0015142 + +[Term] +id: GO:0005313 +name: L-glutamate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "glutamate/aspartate porter activity" NARROW [] +synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] +synonym: "L-glutamate transporter activity" BROAD [] +is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0005314 +name: high-affinity glutamate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in)." [TC:2.A.3.10.5] +synonym: "high-affinity glutamate transporter activity" BROAD [] +is_a: GO:0005313 ! L-glutamate transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005315 +name: inorganic phosphate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005317 +def: "Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +subset: gosubset_prok +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0005316 +name: high affinity inorganic phosphate:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in)." [TC:2.A.20.2.2] +synonym: "sodium/phosphate cotransporter" BROAD [] +is_a: GO:0005436 ! sodium:phosphate symporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005318 +name: phosphate:hydrogen symporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +synonym: "phosphate:proton symporter" EXACT [] +is_obsolete: true +consider: GO:0015317 + +[Term] +id: GO:0005319 +name: lipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of lipids into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "apolipoprotein" RELATED [] +synonym: "high-density lipoprotein" RELATED [] +synonym: "lipophorin" NARROW [] +synonym: "low-density lipoprotein" RELATED [] +synonym: "very-low-density lipoprotein" RELATED [] +xref: Reactome:7042 +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0005320 +name: apolipoprotein +namespace: molecular_function +alt_id: GO:0015907 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0005319 + +[Term] +id: GO:0005321 +name: high-density lipoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "HDL" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0005322 +name: low-density lipoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "LDL" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0005323 +name: very-low-density lipoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "VLDL" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0005324 +name: long-chain fatty acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of long-chain fatty acids into, out of, within or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "plasma membrane long-chain fatty acid transporter" NARROW [] +is_a: GO:0015245 ! fatty acid transporter activity + +[Term] +id: GO:0005325 +name: peroxisomal fatty acyl CoA transporter activity +namespace: molecular_function +alt_id: GO:0008562 +def: "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47] +synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47] +synonym: "fatty-acyl-CoA-transporting ATPase" BROAD [] +xref: EC:3.6.3.47 +is_a: GO:0005324 ! long-chain fatty acid transporter activity +is_a: GO:0015607 ! fatty acyl CoA transporter activity + +[Term] +id: GO:0005326 +name: neurotransmitter transporter activity +namespace: molecular_function +def: "Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0005328 +name: neurotransmitter:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] +subset: gosubset_prok +synonym: "sodium/neurotransmitter symporter" EXACT [] +is_a: GO:0005326 ! neurotransmitter transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005329 +name: dopamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0005330 +name: dopamine:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3] +synonym: "sodium/dopamine symporter" EXACT [] +is_a: GO:0005328 ! neurotransmitter:sodium symporter activity +is_a: GO:0005329 ! dopamine transmembrane transporter activity + +[Term] +id: GO:0005332 +name: gamma-aminobutyric acid:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] +comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. +synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] +synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] +synonym: "betaine/GABA:sodium symporter activity" EXACT [] +synonym: "GABA:sodium symporter activity" EXACT [] +synonym: "sodium/chloride-dependent GABA transporter" RELATED [] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity + +[Term] +id: GO:0005333 +name: norepinephrine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "levarterenol transporter" EXACT [] +synonym: "noradrenaline transporter" EXACT [] +is_a: GO:0005326 ! neurotransmitter transporter activity +is_a: GO:0008504 ! monoamine transmembrane transporter activity + +[Term] +id: GO:0005334 +name: norephinephrine:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2] +synonym: "noradrenaline:sodium symporter activity" EXACT [] +synonym: "sodium/norepinephrine symporter" EXACT [] +is_a: GO:0005328 ! neurotransmitter:sodium symporter activity +is_a: GO:0005333 ! norepinephrine transmembrane transporter activity + +[Term] +id: GO:0005335 +name: serotonin:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005336 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1] +synonym: "sodium/serotonin symporter" EXACT [] +is_a: GO:0005328 ! neurotransmitter:sodium symporter activity + +[Term] +id: GO:0005337 +name: nucleoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] +is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity + +[Term] +id: GO:0005338 +name: nucleotide-sugar transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005339 +def: "Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0005340 +name: nucleotide-sulfate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005341 +def: "Catalysis of the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] +synonym: "nucleotide-sulphate transporter activity" EXACT [] +is_a: GO:0015116 ! sulfate transmembrane transporter activity + +[Term] +id: GO:0005342 +name: organic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0005343 +name: organic acid:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] +subset: gosubset_prok +synonym: "sodium/chloride-dependent organic acid cotransporter" NARROW [] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +is_a: GO:0005342 ! organic acid transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005344 +name: oxygen transporter activity +namespace: molecular_function +alt_id: GO:0015033 +def: "Enables the directed movement of oxygen into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "globin" NARROW [] +synonym: "hemerythrin" NARROW [] +synonym: "hemocyanin" NARROW [] +synonym: "oxygen-carrying" NARROW [] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0005345 +name: purine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015205 ! nucleobase transmembrane transporter activity + +[Term] +id: GO:0005346 +name: purine ribonucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity + +[Term] +id: GO:0005347 +name: ATP transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005348 +def: "Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity + +[Term] +id: GO:0005350 +name: pyrimidine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015205 ! nucleobase transmembrane transporter activity + +[Term] +id: GO:0005351 +name: sugar:hydrogen symporter activity +namespace: molecular_function +alt_id: GO:0005403 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] +subset: gosubset_prok +synonym: "cation/sugar symporter activity" BROAD [] +synonym: "hydrogen:sugar symporter activity" EXACT [] +synonym: "hydrogen:sugar transporter activity" BROAD [] +synonym: "proton:sugar symporter activity" EXACT [] +synonym: "sugar porter activity" RELATED [] +synonym: "sugar transporter" BROAD [] +synonym: "sugar:hydrogen ion symporter activity" EXACT [] +is_a: GO:0005402 ! cation:sugar symporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0051119 ! sugar transmembrane transporter activity + +[Term] +id: GO:0005352 +name: alpha-glucoside:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] +synonym: "general alpha-glucoside transporter activity" BROAD [] +synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] +synonym: "general alpha-glucoside:proton symporter activity" EXACT [] +is_a: GO:0005402 ! cation:sugar symporter activity +is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity + +[Term] +id: GO:0005353 +name: fructose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015585 +alt_id: GO:0019192 +def: "Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "fructose permease activity" EXACT [] +synonym: "fructose porter activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0005354 +name: galactose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0005355 +name: glucose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015579 +def: "Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] +synonym: "glucose permease activity" EXACT [] +synonym: "lactose/glucose efflux transporter activity" NARROW [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0005356 +name: hydrogen:glucose symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "hydrogen:glucose transporter activity" RELATED [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0009679 ! hexose:hydrogen symporter activity + +[Term] +id: GO:0005357 +name: constitutive hydrogen:glucose symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constituitive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "constitutive hydrogen/glucose transporter" EXACT [] +synonym: "constitutive hydrogen:glucose transporter activity" RELATED [] +is_a: GO:0005356 ! hydrogen:glucose symporter activity + +[Term] +id: GO:0005358 +name: high-affinity hydrogen:glucose symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constituitive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high-affinity hydrogen/glucose transporter" EXACT [] +synonym: "high-affinity hydrogen:glucose transporter activity" RELATED [] +is_a: GO:0005356 ! hydrogen:glucose symporter activity + +[Term] +id: GO:0005359 +name: low-affinity hydrogen:glucose symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "low-affinity hydrogen/glucose transporter" EXACT [] +synonym: "low-affinity hydrogen:glucose transporter activity" RELATED [] +is_a: GO:0005356 ! hydrogen:glucose symporter activity + +[Term] +id: GO:0005360 +name: insulin-responsive hydrogen:glucose symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] +synonym: "transepithelial hydrogen/glucose transporter" RELATED [] +is_a: GO:0005356 ! hydrogen:glucose symporter activity + +[Term] +id: GO:0005361 +name: transepithelial hydrogen:glucose symporter activity +namespace: molecular_function +synonym: "transepithelial hydrogen/glucose transporter" EXACT [] +synonym: "transepithelial hydrogen:glucose transporter activity" RELATED [] +is_a: GO:0005356 ! hydrogen:glucose symporter activity + +[Term] +id: GO:0005362 +name: low-affinity glucose:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] +synonym: "low-affinity glucose-sodium cotransporter" BROAD [] +is_a: GO:0005412 ! glucose:sodium symporter activity + +[Term] +id: GO:0005363 +name: maltose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015581 +def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "maltose porter activity" EXACT [] +is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0005364 +name: maltose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] +synonym: "hydrogen/maltose transporter" NARROW [] +synonym: "maltose permease" BROAD [] +synonym: "maltose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0005363 ! maltose transmembrane transporter activity + +[Term] +id: GO:0005365 +name: myo-inositol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin Bh transporter activity" EXACT [] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0005366 +name: myo-inositol:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] +synonym: "hydrogen/myo-inositol transporter" BROAD [] +synonym: "myo-inositol:proton symporter" EXACT [] +is_a: GO:0005365 ! myo-inositol transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity + +[Term] +id: GO:0005367 +name: myo-inositol:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] +synonym: "myo-inositol-sodium cotransporter" BROAD [] +is_a: GO:0005365 ! myo-inositol transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005368 +name: taurine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0005369 +name: taurine:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] +synonym: "sodium/chloride-dependent taurine transporter" BROAD [] +is_a: GO:0005328 ! neurotransmitter:sodium symporter activity +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0005368 ! taurine transmembrane transporter activity + +[Term] +id: GO:0005371 +name: tricarboxylate secondary active transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005370 +def: "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "citrate carrier" EXACT [] +synonym: "tricarboxylate carrier activity" EXACT [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0005372 +name: water transporter activity +namespace: molecular_function +def: "Enables the directed movement of water (H2O) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0005373 +name: heavy metal ion porter activity +namespace: molecular_function +def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "metal ion transporter" BROAD [] +is_obsolete: true +consider: GO:0015291 +consider: GO:0046873 + +[Term] +id: GO:0005375 +name: copper ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005378 +alt_id: GO:0005379 +alt_id: GO:0005380 +def: "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "intracellular copper ion transporter" NARROW [] +synonym: "plasma membrane copper transporter" NARROW [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005376 +name: plasma membrane copper transporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0005375 +consider: GO:0005886 + +[Term] +id: GO:0005377 +name: intracellular copper ion transporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "intracellular copper transporter" EXACT [] +is_obsolete: true +replaced_by: GO:0005375 +replaced_by: GO:0005622 + +[Term] +id: GO:0005381 +name: iron ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005382 +alt_id: GO:0016033 +def: "Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "iron transporter" EXACT [] +synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] +synonym: "transmembrane iron ion permease activity" EXACT [] +synonym: "transmembrane iron permease activity" EXACT [] +synonym: "zinc, iron permease activity" RELATED [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005384 +name: manganese ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:df] +subset: gosubset_prok +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005385 +name: zinc ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:df] +subset: gosubset_prok +synonym: "cobalt, zinc uptake permease activity" NARROW [] +synonym: "zinc, cadmium uptake permease activity" NARROW [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +synonym: "zinc, iron permease activity" NARROW [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005388 +name: calcium-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8] +synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8] +synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8] +synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8] +synonym: "calcium ABC transporter" NARROW [] +synonym: "calcium efflux ATPase" NARROW [] +synonym: "calcium pump" BROAD [] +synonym: "calcium transporting ATPase activity" EXACT [] +synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8] +synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8] +synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8] +synonym: "sarcoplasmic reticulum ATPase" NARROW [] +xref: EC:3.6.3.8 +xref: MetaCyc:3.6.3.8-RXN +is_a: GO:0015085 ! calcium ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0005391 +name: sodium:potassium-exchanging ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9] +synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9] +synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9] +synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9] +synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9] +synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9] +synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9] +synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9] +synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] +synonym: "na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] +synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9] +synonym: "Na,K-pump" RELATED [EC:3.6.3.9] +synonym: "sodium pump" BROAD [] +synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] +synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9] +synonym: "sodium:potassium exchanging ATPase activity" EXACT [] +xref: EC:3.6.3.9 +xref: MetaCyc:3.6.3.9-RXN +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0005395 +name: eye pigment precursor transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0005396 +name: transmembrane conductance regulator activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. +is_obsolete: true +consider: GO:0043267 + +[Term] +id: GO:0005400 +name: peroxisomal membrane transporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0005215 +consider: GO:0005777 + +[Term] +id: GO:0005402 +name: cation:sugar symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] +subset: gosubset_prok +synonym: "cation/sugar symporter" EXACT [] +synonym: "sugar:cation symporter activity" EXACT [] +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0005412 +name: glucose:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] +synonym: "sodium/glucose symporter" EXACT [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005415 +name: nucleoside:sodium symporter activity +namespace: molecular_function +alt_id: GO:0008522 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "nucleoside-sodium cotransporter" BROAD [] +synonym: "sodium-dependent nucleoside transporter" BROAD [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005416 +name: cation:amino acid symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] +subset: gosubset_prok +synonym: "cation/amino acid symporter" EXACT [] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0005427 +name: proton-dependent oligopeptide secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] +subset: gosubset_prok +synonym: "hydrogen/oligopeptide symporter" RELATED [] +synonym: "proton-dependent oligopeptide transporter activity" EXACT [] +is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity + +[Term] +id: GO:0005429 +name: chromaffin granule amine transmembrane transporter activity +namespace: molecular_function +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0005430 +name: synaptic vesicle amine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of amines across synaptic vesicle membranes." [GOC:ai] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0005432 +name: calcium:sodium antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [UniProtKB:P70414] +subset: gosubset_prok +synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] +synonym: "sodium/calcium exchanger" EXACT [] +synonym: "sodium:calcium exchange" RELATED [] +is_a: GO:0015368 ! calcium:cation antiporter activity + +[Term] +id: GO:0005436 +name: sodium:phosphate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] +subset: gosubset_prok +synonym: "sodium/phosphate symporter" EXACT [] +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0005451 +name: monovalent cation:proton antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0015299 ! solute:hydrogen antiporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0005452 +name: inorganic anion exchanger activity +namespace: molecular_function +is_a: GO:0015380 ! anion exchanger activity + +[Term] +id: GO:0005456 +name: CMP-sialic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a CMP-sialic acid from one side of the membrane to the other. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005457 +name: GDP-fucose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005458 +name: GDP-mannose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005459 +name: UDP-galactose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005460 +name: UDP-glucose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005461 +name: UDP-glucuronic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:15054 +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005462 +name: UDP-N-acetylglucosamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005463 +name: UDP-N-acetylgalactosamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005464 +name: UDP-xylose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity + +[Term] +id: GO:0005468 +name: small-molecule carrier or transporter +namespace: molecular_function +alt_id: GO:0005453 +alt_id: GO:0005454 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not provide a useful functional classification. +is_obsolete: true +consider: GO:0005215 + +[Term] +id: GO:0005469 +name: succinate:fumarate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] +is_a: GO:0015138 ! fumarate transmembrane transporter activity +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0005471 +name: ATP:ADP antiporter activity +namespace: molecular_function +alt_id: GO:0005349 +def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] +subset: gosubset_prok +synonym: "adenine nucleotide translocase" EXACT [] +synonym: "ADP/ATP translocase" EXACT [] +synonym: "ATP/ADP exchange" EXACT [] +synonym: "ATP/ADP exchanger" EXACT [] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0005472 +name: FAD carrier activity +namespace: molecular_function +synonym: "flavin adenine dinucleotide carrier activity" EXACT [] +synonym: "flavin-adenine dinucleotide carrier activity" EXACT [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0005476 +name: carnitine:acyl carnitine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] +synonym: "carnitine/acyl carnitine carrier activity" EXACT [] +synonym: "carnitine:acyl carnitine carrier activity" EXACT [] +synonym: "fatty acyl carnitine carrier" EXACT [] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0005477 +name: pyruvate secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "pyruvate carrier activity" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0050833 ! pyruvate transmembrane transporter activity + +[Term] +id: GO:0005479 +name: vacuolar assembly +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +is_obsolete: true +replaced_by: GO:0007033 + +[Term] +id: GO:0005480 +name: vesicle transport +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +is_obsolete: true +replaced_by: GO:0016192 + +[Term] +id: GO:0005481 +name: vesicle fusion +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +is_obsolete: true +consider: GO:0006906 +consider: GO:0007086 +consider: GO:0016189 +consider: GO:0016192 +consider: GO:0019817 + +[Term] +id: GO:0005482 +name: vesicle targeting +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +is_obsolete: true +consider: GO:0006903 +consider: GO:0016080 + +[Term] +id: GO:0005483 +name: soluble NSF attachment protein activity +namespace: molecular_function +def: "Interacting selectively with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] +synonym: "SNAP" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005484 +name: SNAP receptor activity +namespace: molecular_function +alt_id: GO:0005485 +alt_id: GO:0005486 +def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] +synonym: "Q-SNARE activity" NARROW [] +synonym: "R-SNARE activity" NARROW [] +synonym: "SNAP-25" NARROW [] +synonym: "SNARE" EXACT [] +synonym: "t-SNARE activity" NARROW [] +synonym: "v-SNARE activity" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005487 +name: nucleocytoplasmic transporter activity +namespace: molecular_function +def: "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai] +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0005488 +name: binding +namespace: molecular_function +def: "The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "ligand" NARROW [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005489 +name: electron transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai] +comment: This term was made obsolete because the activity described by the definition does not exist. +synonym: "class I cytochrome c" RELATED [] +synonym: "class II cytochrome c" RELATED [] +synonym: "class IIa cytochrome c" RELATED [] +synonym: "class IIb cytochrome c" RELATED [] +synonym: "class III cytochrome c" RELATED [] +synonym: "class IV cytochrome c" RELATED [] +synonym: "cytochrome b" RELATED [] +synonym: "cytochrome b5" RELATED [] +synonym: "cytochrome c3 (tetraheme)" RELATED [] +synonym: "cytochrome c554" RELATED [] +synonym: "cytochrome c7 (triheme)" RELATED [] +synonym: "cytochrome d" RELATED [] +synonym: "diheme class I cytochrome c" RELATED [] +synonym: "electron transfer carrier" RELATED [] +synonym: "flavin-containing electron transporter" RELATED [] +synonym: "flavodoxin" RELATED [] +synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED [] +synonym: "monoheme class I cytochrome c" RELATED [] +synonym: "nonaheme cytochrome c" RELATED [] +synonym: "respiratory chain cytochrome b6" RELATED [] +synonym: "Rieske iron-sulfur protein" RELATED [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0005490 +name: cytochrome P450 +namespace: molecular_function +def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684] +comment: This term was made obsolete because its definition was changed and because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0005496 +name: steroid binding +namespace: molecular_function +def: "Interacting selectively with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0005497 +name: androgen binding +namespace: molecular_function +def: "Interacting selectively with any androgen, male sex hormones." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0005496 ! steroid binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0005498 +name: sterol carrier activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0032934 ! sterol binding + +[Term] +id: GO:0005499 +name: vitamin D binding +namespace: molecular_function +def: "Interacting selectively with vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol." [GOC:ai] +synonym: "calciferol binding" EXACT [] +synonym: "cholecalciferol binding" NARROW [] +synonym: "ergocalciferol binding" NARROW [] +is_a: GO:0005496 ! steroid binding +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0005500 +name: juvenile hormone binding +namespace: molecular_function +def: "Interacting selectively with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0005501 +name: retinoid binding +namespace: molecular_function +def: "Interacting selectively with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0019840 ! isoprenoid binding + +[Term] +id: GO:0005502 +name: 11-cis retinal binding +namespace: molecular_function +def: "Interacting selectively with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [http://cancerweb.ncl.ac.uk/] +synonym: "11-cis retinaldehyde binding" EXACT [] +synonym: "vitamin A binding" BROAD [] +is_a: GO:0016918 ! retinal binding + +[Term] +id: GO:0005503 +name: all-trans retinal binding +namespace: molecular_function +def: "Interacting selectively with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [http://cancerweb.ncl.ac.uk/] +synonym: "all-trans retinaldehyde binding" EXACT [] +synonym: "trans retinal binding" EXACT [] +synonym: "visual yellow binding" EXACT [] +synonym: "vitamin A binding" BROAD [] +synonym: "xanthopsin" RELATED [] +is_a: GO:0016918 ! retinal binding + +[Term] +id: GO:0005504 +name: fatty acid binding +namespace: molecular_function +def: "Interacting selectively with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0005505 +name: heavy metal binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +is_obsolete: true +consider: GO:0046872 + +[Term] +id: GO:0005506 +name: iron ion binding +namespace: molecular_function +def: "Interacting selectively with iron (Fe) ions." [GOC:ai] +subset: gosubset_prok +synonym: "iron binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0005507 +name: copper ion binding +namespace: molecular_function +def: "Interacting selectively with copper (Cu) ions." [GOC:ai] +subset: gosubset_prok +synonym: "copper binding" EXACT [] +synonym: "copper/cadmium binding" BROAD [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0005508 +name: copper/cadmium binding +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a composite function. +is_obsolete: true +consider: GO:0005507 +consider: GO:0046870 + +[Term] +id: GO:0005509 +name: calcium ion binding +namespace: molecular_function +def: "Interacting selectively with calcium ions (Ca2+)." [GOC:ai] +subset: goslim_generic +subset: gosubset_prok +synonym: "calcium ion storage activity" RELATED [] +is_a: GO:0043169 ! cation binding +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0005513 +name: detection of calcium ion +namespace: biological_process +def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg] +synonym: "Ca2+ ion detection" EXACT [] +synonym: "calcium ion detection" EXACT [] +synonym: "calcium ion sensing" EXACT [] +synonym: "detection of Ca2+ ion" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051592 ! response to calcium ion + +[Term] +id: GO:0005514 +name: calcium ion storage activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0005509 +replaced_by: GO:0051208 + +[Term] +id: GO:0005515 +name: protein binding +namespace: molecular_function +alt_id: GO:0045308 +def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED [] +synonym: "protein amino acid binding" EXACT [] +synonym: "protein degradation tagging activity" RELATED [] +synonym: "protein tagging activity" RELATED [] +xref: Reactome:6125 +is_a: GO:0005488 ! binding + +[Term] +id: GO:0005516 +name: calmodulin binding +namespace: molecular_function +def: "Interacting selectively with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] +subset: gosubset_prok +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005517 +name: calmodulin inhibitor activity +namespace: molecular_function +is_a: GO:0005516 ! calmodulin binding + +[Term] +id: GO:0005518 +name: collagen binding +namespace: molecular_function +def: "Interacting selectively with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005519 +name: cytoskeletal regulatory protein binding +namespace: molecular_function +def: "Interacting selectively with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0005520 +name: insulin-like growth factor binding +namespace: molecular_function +def: "Interacting selectively with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "IGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0005521 +name: lamin binding +namespace: molecular_function +def: "Interacting selectively with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "lamin/chromatin binding" BROAD [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005522 +name: profilin binding +namespace: molecular_function +def: "Interacting selectively with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005523 +name: tropomyosin binding +namespace: molecular_function +def: "Interacting selectively with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0005524 +name: ATP binding +namespace: molecular_function +def: "Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0032559 ! adenyl ribonucleotide binding + +[Term] +id: GO:0005525 +name: GTP binding +namespace: molecular_function +def: "Interacting selectively with GTP, guanosine triphosphate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0032561 ! guanyl ribonucleotide binding + +[Term] +id: GO:0005527 +name: macrolide binding +namespace: molecular_function +def: "Interacting selectively with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0005528 +name: FK506 binding +namespace: molecular_function +def: "Interacting selectively with the immunosuppressant FK506." [GOC:jl] +synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] +is_a: GO:0005527 ! macrolide binding + +[Term] +id: GO:0005529 +name: sugar binding +namespace: molecular_function +def: "Interacting selectively with any mono-, di- or trisaccharide carbohydrate." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0030246 ! carbohydrate binding + +[Term] +id: GO:0005530 +name: lectin +namespace: molecular_function +def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [http://cancerweb.ncl.ac.uk/] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +consider: GO:0005529 +consider: GO:0007157 + +[Term] +id: GO:0005531 +name: galactose binding lectin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +consider: GO:0005534 +consider: GO:0007157 + +[Term] +id: GO:0005532 +name: mannose binding lectin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "mannose receptor" RELATED [] +is_obsolete: true +consider: GO:0005537 +consider: GO:0007157 + +[Term] +id: GO:0005533 +name: N-acetylgalactosamine lectin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +consider: GO:0007157 +consider: GO:0046871 + +[Term] +id: GO:0005534 +name: galactose binding +namespace: molecular_function +def: "Interacting selectively with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [ChEBI:28260, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactose binding lectin" RELATED [] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0005536 +name: glucose binding +namespace: molecular_function +def: "Interacting selectively with the D- or L-enantiomer of glucose." [ChEBI:17234, GOC:jl] +subset: gosubset_prok +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0005537 +name: mannose binding +namespace: molecular_function +def: "Interacting selectively with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [ChEBI:37684, GOC:jl, ISBN:0192800981] +subset: gosubset_prok +synonym: "mannose binding lectin" RELATED [] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0005539 +name: glycosaminoglycan binding +namespace: molecular_function +def: "Interacting selectively with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0005540 +name: hyaluronic acid binding +namespace: molecular_function +def: "Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "hyaluronan binding" EXACT [] +is_a: GO:0005539 ! glycosaminoglycan binding + +[Term] +id: GO:0005541 +name: acyl-CoA or acyl binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it was replaced by more appropriate terms. +is_obsolete: true +consider: GO:0000035 +consider: GO:0000062 + +[Term] +id: GO:0005542 +name: folic acid binding +namespace: molecular_function +def: "Interacting selectively with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "folate binding" EXACT [] +synonym: "vitamin B9 binding" EXACT [] +synonym: "vitamin M binding" EXACT [] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0005543 +name: phospholipid binding +namespace: molecular_function +def: "Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0005544 +name: calcium-dependent phospholipid binding +namespace: molecular_function +def: "Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0005545 +name: phosphatidylinositol binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0005546 +name: phosphatidylinositol-4,5-bisphosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol-4,5-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [GOC:bf, GOC:jl] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0005547 +name: phosphatidylinositol-3,4,5-triphosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol-3,4,5-triphosphate, the triphosphorylated derivative of phosphatidylinositol." [GOC:bf, GOC:jl] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0005548 +name: phospholipid transporter activity +namespace: molecular_function +alt_id: GO:0008497 +def: "Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0005549 +name: odorant binding +namespace: molecular_function +def: "Interacting selectively with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0005550 +name: pheromone binding +namespace: molecular_function +def: "Interacting selectively with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] +is_a: GO:0005549 ! odorant binding + +[Term] +id: GO:0005551 +name: ubiquitin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0016567 +consider: GO:0031386 + +[Term] +id: GO:0005552 +name: polyubiquitin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0000209 + +[Term] +id: GO:0005553 +name: ubiquitin-ribosomal protein fusion protein +namespace: molecular_function +def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it describes a gene product. +is_obsolete: true + +[Term] +id: GO:0005555 +name: blood group antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true + +[Term] +id: GO:0005557 +name: lymphocyte antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true + +[Term] +id: GO:0005558 +name: minor histocompatibility antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true + +[Term] +id: GO:0005559 +name: ribozyme +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005561 +name: nucleic acid +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005562 +name: RNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005563 +name: transfer RNA +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0030533 + +[Term] +id: GO:0005564 +name: cytosolic tRNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005565 +name: mitochondrial tRNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005566 +name: ribosomal RNA +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0003735 +consider: GO:0005840 + +[Term] +id: GO:0005567 +name: cytosolic ribosomal RNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005568 +name: mitochondrial rRNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005569 +name: small nucleolar RNA +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents gene products. +is_obsolete: true +consider: GO:0030555 + +[Term] +id: GO:0005570 +name: small nuclear RNA +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents gene products. +is_obsolete: true +consider: GO:0017069 +consider: GO:0031202 + +[Term] +id: GO:0005571 +name: untranslated RNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005572 +name: RNA polymerase II transcribed untranslated RNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005573 +name: telomerase RNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0000332 + +[Term] +id: GO:0005574 +name: DNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +is_obsolete: true + +[Term] +id: GO:0005575 +name: cellular_component +namespace: cellular_component +alt_id: GO:0008372 +def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators] +comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "cellular component" EXACT [] +synonym: "cellular component unknown" NARROW [] + +[Term] +id: GO:0005576 +name: extracellular region +namespace: cellular_component +def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] +comment: Note that this term is intended to annotate gene products that are not uniformly attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "extracellular" EXACT [] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0005577 +name: fibrinogen complex +namespace: cellular_component +def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] +synonym: "fibrinogen" EXACT [] +synonym: "fibrinogen alpha chain" NARROW [] +synonym: "fibrinogen beta chain" NARROW [] +synonym: "fibrinogen gamma chain" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005578 +name: proteinaceous extracellular matrix +namespace: cellular_component +def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity." [GOC:mtg_sensu, ISBN:0198547684] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +synonym: "extracellular matrix (sensu Metazoa)" EXACT [] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0005579 +name: membrane attack complex +namespace: cellular_component +def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] +synonym: "MAC" EXACT [] +synonym: "membrane attack complex protein alphaM chain" NARROW [] +synonym: "membrane attack complex protein beta2 chain" NARROW [] +synonym: "TCC" EXACT [] +synonym: "terminal complement complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0046930 ! pore complex +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005580 +name: membrane attack complex protein alphaM chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005579 + +[Term] +id: GO:0005581 +name: collagen +namespace: cellular_component +def: "Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976] +synonym: "other collagen" RELATED [] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0005582 +name: collagen type XV +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes." [PMID:11158616, PMID:11937714] +is_a: GO:0005581 ! collagen + +[Term] +id: GO:0005583 +name: fibrillar collagen +namespace: cellular_component +def: "Any collagen polymer in which collagen triple helices associate to form fibrils." [GOC:mah, ISBN:0721639976] +is_a: GO:0005581 ! collagen + +[Term] +id: GO:0005584 +name: collagen type I +namespace: cellular_component +def: "A collagen heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; type I collagen triple helices associate to form banded fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen + +[Term] +id: GO:0005585 +name: collagen type II +namespace: cellular_component +def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen + +[Term] +id: GO:0005586 +name: collagen type III +namespace: cellular_component +def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen + +[Term] +id: GO:0005587 +name: collagen type IV +namespace: cellular_component +def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes." [ISBN:0721639976] +is_a: GO:0030935 ! sheet-forming collagen +relationship: part_of GO:0005604 ! basement membrane + +[Term] +id: GO:0005588 +name: collagen type V +namespace: cellular_component +def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen + +[Term] +id: GO:0005589 +name: collagen type VI +namespace: cellular_component +def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976] +is_a: GO:0030934 ! anchoring collagen + +[Term] +id: GO:0005590 +name: collagen type VII +namespace: cellular_component +def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue." [ISBN:0721639976] +is_a: GO:0030934 ! anchoring collagen + +[Term] +id: GO:0005591 +name: collagen type VIII +namespace: cellular_component +def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976] +is_a: GO:0005598 ! short-chain collagen + +[Term] +id: GO:0005592 +name: collagen type XI +namespace: cellular_component +def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen + +[Term] +id: GO:0005593 +name: FACIT collagen +namespace: cellular_component +def: "Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix." [ISBN:0198599587] +is_a: GO:0030934 ! anchoring collagen + +[Term] +id: GO:0005594 +name: collagen type IX +namespace: cellular_component +def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] +is_a: GO:0005593 ! FACIT collagen + +[Term] +id: GO:0005595 +name: collagen type XII +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] +is_a: GO:0005593 ! FACIT collagen + +[Term] +id: GO:0005596 +name: collagen type XIV +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] +is_a: GO:0005593 ! FACIT collagen + +[Term] +id: GO:0005597 +name: collagen type XVI +namespace: cellular_component +def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] +is_a: GO:0005593 ! FACIT collagen + +[Term] +id: GO:0005598 +name: short-chain collagen +namespace: cellular_component +def: "Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens." [ISBN:0198599587] +is_a: GO:0030935 ! sheet-forming collagen + +[Term] +id: GO:0005599 +name: collagen type X +namespace: cellular_component +def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets." [ISBN:0721639976] +is_a: GO:0005598 ! short-chain collagen + +[Term] +id: GO:0005600 +name: collagen type XIII +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes." [ISBN:0721639976] +is_a: GO:0030936 ! transmembrane collagen + +[Term] +id: GO:0005601 +name: classical-complement-pathway C3/C5 convertase complex +namespace: cellular_component +def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005602 +name: complement component C1 complex +namespace: cellular_component +def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "complement component C1q complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005603 +name: complement component C2 complex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entitiy corresponding to "complement C2 complex". +is_obsolete: true + +[Term] +id: GO:0005604 +name: basement membrane +namespace: cellular_component +def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0005605 +name: basal lamina +namespace: cellular_component +def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684] +synonym: "basement lamina" EXACT [] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005604 ! basement membrane + +[Term] +id: GO:0005606 +name: laminin-1 complex +namespace: cellular_component +def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005607 +name: laminin-2 complex +namespace: cellular_component +def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0005608 +name: laminin-3 complex +namespace: cellular_component +def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005609 +name: laminin-4 complex +namespace: cellular_component +def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005610 +name: laminin-5 complex +namespace: cellular_component +def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005611 +name: laminin-6 complex +namespace: cellular_component +def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005612 +name: laminin-7 complex +namespace: cellular_component +def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005613 +name: laminin receptor protein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. +is_obsolete: true +consider: GO:0008305 + +[Term] +id: GO:0005614 +name: interstitial matrix +namespace: cellular_component +def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] +is_a: GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0005615 +name: extracellular space +namespace: cellular_component +def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] +comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +synonym: "intercellular space" RELATED [] +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0005616 +name: larval serum protein complex +namespace: cellular_component +def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, UniProtKB:P11995] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005617 +name: larval serum protein-1 +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "LSP1" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005618 +name: cell wall +namespace: cellular_component +def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0005619 +name: fungal-type spore wall +namespace: cellular_component +def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division." [GOC:vw, ISBN:0879693568] +synonym: "spore wall (sensu Fungi)" EXACT [] +is_a: GO:0031160 ! spore wall + +[Term] +id: GO:0005621 +name: cellular bud scar +namespace: cellular_component +def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0005622 +name: intracellular +namespace: cellular_component +def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "protoplasm" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0005623 +name: cell +namespace: cellular_component +def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0005624 +name: membrane fraction +namespace: cellular_component +def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +subset: goslim_candida +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0005626 ! insoluble fraction + +[Term] +id: GO:0005625 +name: soluble fraction +namespace: cellular_component +def: "That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +synonym: "soluble" BROAD [] +is_a: GO:0000267 ! cell fraction + +[Term] +id: GO:0005626 +name: insoluble fraction +namespace: cellular_component +def: "That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +subset: gosubset_prok +synonym: "particle-bound" RELATED [] +is_a: GO:0000267 ! cell fraction + +[Term] +id: GO:0005627 +name: ascus +namespace: cellular_component +def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684] +comment: This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'. +is_obsolete: true + +[Term] +id: GO:0005628 +name: prospore membrane +namespace: cellular_component +def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls." [ISBN:0879693649] +subset: gosubset_prok +synonym: "forespore membrane (sensu Fungi)" EXACT [] +synonym: "FSM" EXACT [] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:0005630 +name: dityrosine layer of spore wall +namespace: cellular_component +def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0005619 ! fungal-type spore wall + +[Term] +id: GO:0005631 +name: chitosan layer of spore wall +namespace: cellular_component +def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0005619 ! fungal-type spore wall + +[Term] +id: GO:0005632 +name: inner layer of spore wall +namespace: cellular_component +def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0005619 ! fungal-type spore wall + +[Term] +id: GO:0005633 +name: ascus lipid droplet +namespace: cellular_component +def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] +is_a: GO:0005811 ! lipid particle + +[Term] +id: GO:0005634 +name: nucleus +namespace: cellular_component +def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "cell nucleus" EXACT [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0005635 +name: nuclear envelope +namespace: cellular_component +alt_id: GO:0005636 +def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] +subset: goslim_generic +subset: goslim_plant +is_a: GO:0031967 ! organelle envelope +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0005637 +name: nuclear inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] +synonym: "inner envelope" BROAD [] +is_a: GO:0019866 ! organelle inner membrane +is_a: GO:0031965 ! nuclear membrane + +[Term] +id: GO:0005638 +name: lamin filament +namespace: cellular_component +def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] +synonym: "type V intermediate filament" EXACT [] +is_a: GO:0005882 ! intermediate filament +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005652 ! nuclear lamina + +[Term] +id: GO:0005639 +name: integral to nuclear inner membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] +is_a: GO:0031229 ! intrinsic to nuclear inner membrane +is_a: GO:0031301 ! integral to organelle membrane + +[Term] +id: GO:0005640 +name: nuclear outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] +synonym: "outer envelope" BROAD [] +synonym: "perinuclear membrane" EXACT [] +is_a: GO:0031965 ! nuclear membrane +is_a: GO:0031968 ! organelle outer membrane +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network + +[Term] +id: GO:0005641 +name: nuclear envelope lumen +namespace: cellular_component +alt_id: GO:0005653 +def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] +comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. +synonym: "nuclear intermembrane space" EXACT [] +synonym: "nuclear membrane lumen" RELATED [] +synonym: "perinuclear space" EXACT [] +is_a: GO:0031970 ! organelle envelope lumen +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0005642 +name: annulate lamellae +namespace: cellular_component +def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network + +[Term] +id: GO:0005643 +name: nuclear pore +namespace: cellular_component +alt_id: GO:0005644 +def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] +subset: goslim_pir +synonym: "NPC" EXACT [] +synonym: "nuclear pore complex" EXACT [] +synonym: "nuclear pore membrane protein" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part +is_a: GO:0046930 ! pore complex +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0005645 +name: RAN-binding protein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0008536 +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005646 +name: importin +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "karyopherin" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005647 +name: importin, alpha-subunit +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "karyopherin-alpha" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005648 +name: importin, beta-subunit +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "karyopherin-beta1" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005649 +name: transportin +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "karyopherin-beta2" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005650 +name: importin, alpha-subunit transport factor +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "CAS" RELATED [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005651 +name: exportin +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005652 +name: nuclear lamina +namespace: cellular_component +def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005637 ! nuclear inner membrane +relationship: part_of GO:0034399 ! nuclear periphery + +[Term] +id: GO:0005654 +name: nucleoplasm +namespace: cellular_component +def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] +subset: goslim_generic +subset: goslim_plant +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0005655 +name: nucleolar ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] +synonym: "nucleolar RNase P complex" EXACT [] +is_a: GO:0030681 ! multimeric ribonuclease P complex +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0005656 +name: pre-replicative complex +namespace: cellular_component +def: "A multiprotein complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] +synonym: "pre-RC" EXACT [] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0005657 +name: replication fork +namespace: cellular_component +def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "replication focus" RELATED [] +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0005658 +name: alpha DNA polymerase:primase complex +namespace: cellular_component +def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402] +synonym: "DNA polymerase alpha:primase complex" EXACT [] +synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] +synonym: "pol-prim" RELATED [] +synonym: "primosome" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0005660 +name: delta-DNA polymerase cofactor complex +namespace: cellular_component +def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl, UniProtKB:P35249] +comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. +synonym: "delta DNA polymerase cofactor complex" EXACT [] +is_obsolete: true +replaced_by: GO:0005663 +replaced_by: GO:0043626 + +[Term] +id: GO:0005662 +name: DNA replication factor A complex +namespace: cellular_component +def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] +synonym: "replication protein A" EXACT [] +synonym: "RPA" EXACT [] +synonym: "single-stranded DNA-binding protein complex" RELATED [] +synonym: "SSB" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0005663 +name: DNA replication factor C complex +namespace: cellular_component +def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520] +subset: goslim_pir +subset: gosubset_prok +synonym: "activator 1 complex" EXACT [] +synonym: "RFC complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005657 ! replication fork + +[Term] +id: GO:0005664 +name: nuclear origin of replication recognition complex +namespace: cellular_component +def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] +synonym: "eukaryotic ORC" EXACT [] +synonym: "nuclear ORC" EXACT [] +is_a: GO:0000808 ! origin recognition complex +is_a: GO:0044454 ! nuclear chromosome part + +[Term] +id: GO:0005665 +name: DNA-directed RNA polymerase II, core complex +namespace: cellular_component +def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] +synonym: "RNA polymerase II complex" BROAD [] +synonym: "RNAP II complex" BROAD [] +is_a: GO:0044451 ! nucleoplasm part +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0005666 +name: DNA-directed RNA polymerase III complex +namespace: cellular_component +def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] +synonym: "DNA-directed RNA polymerase III activity" RELATED [] +is_a: GO:0044451 ! nucleoplasm part +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex + +[Term] +id: GO:0005667 +name: transcription factor complex +namespace: cellular_component +def: "Any complex, distinct from RNA polymerase, including one or more polypeptides capable of binding DNA at promoters or at cis-acting regulatory sequences, and regulating transcription." [GOC:mah] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0005668 +name: selectivity factor SL1 complex +namespace: cellular_component +def: "A RNA polymerase I-specific protein complex which in humans has two subunits, tata-binding protein (TBP) and TBP-associated factor 1 (TAF1)." [GOC:jl, PMID:9857193] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0005669 +name: transcription factor TFIID complex +namespace: cellular_component +def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0005670 +name: transcription-activating factor, 30kD +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005669 + +[Term] +id: GO:0005671 +name: Ada2/Gcn5/Ada3 transcription activator complex +namespace: cellular_component +def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0005672 +name: transcription factor TFIIA complex +namespace: cellular_component +def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, UniProtKB:P52655] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0005673 +name: transcription factor TFIIE complex +namespace: cellular_component +def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, UniProtKB:P29083] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0005674 +name: transcription factor TFIIF complex +namespace: cellular_component +def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, UniProtKB:P13984] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0005675 +name: holo TFIIH complex +namespace: cellular_component +def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of XPD, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015, UniProtKB:Q13889] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0005677 +name: chromatin silencing complex +namespace: cellular_component +def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0005678 +name: chromatin assembly complex +namespace: cellular_component +def: "Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] +synonym: "nucleosome assembly complex" NARROW [] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0005680 +name: anaphase-promoting complex +namespace: cellular_component +def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, PMID:10465783, PMID:10611969] +comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. +synonym: "anaphase promoting complex" EXACT [] +synonym: "APC" BROAD [] +synonym: "cyclosome" EXACT [] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex + +[Term] +id: GO:0005681 +name: spliceosome +namespace: cellular_component +def: "A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron." [ISBN:0198547684] +subset: goslim_pir +synonym: "spliceosome complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0005682 +name: snRNP U5 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U5; a component of both the major and minor spliceosome complexes." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005684 ! U2-dependent spliceosome +relationship: part_of GO:0005689 ! U12-dependent spliceosome + +[Term] +id: GO:0005683 +name: snRNP U7 +namespace: cellular_component +def: "A ribonucleoprotein complex, that includes the U7 snRNA, required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex + +[Term] +id: GO:0005684 +name: U2-dependent spliceosome +namespace: cellular_component +def: "The major (U2-dependent) spliceosome is composed of five snRNP complexes (U1, U2, U4, U5, and U6) as well as many non-snRNP proteins. It acts through many RNA-RNA, RNA-protein, and protein-protein interactions to precisely excise each intron and join the flanking exons." [PMID:11343900] +synonym: "GT-AG spliceosome" EXACT [] +synonym: "major (U2-dependent) spliceosome" EXACT [] +synonym: "major spliceosome" EXACT [] +is_a: GO:0005681 ! spliceosome + +[Term] +id: GO:0005685 +name: snRNP U1 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U1; a component of the major spliceosome complex." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005684 ! U2-dependent spliceosome + +[Term] +id: GO:0005686 +name: snRNP U2 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U2; a component of the major spliceosome complex." [GOC:krc] +synonym: "17S U2 snRNP" NARROW [] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005684 ! U2-dependent spliceosome + +[Term] +id: GO:0005687 +name: snRNP U4 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U4; a component of the major spliceosome complex." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005684 ! U2-dependent spliceosome + +[Term] +id: GO:0005688 +name: snRNP U6 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U6; a component of the major spliceosome complex." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005684 ! U2-dependent spliceosome + +[Term] +id: GO:0005689 +name: U12-dependent spliceosome +namespace: cellular_component +def: "The minor (U12-dependent) spliceosome is composed of the snRNPs, U11, U12, U4atac, U6atac, and U5 (which is also a component of the major spliceosome). This minor form of the spliceosome is responsible for the splicing of the majority of introns with atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [PMID:11574683, PMID:11971955] +synonym: "AT-AC spliceosome" EXACT [] +synonym: "minor (U12-dependent) spliceosome complex" EXACT [] +synonym: "minor spliceosome" EXACT [] +is_a: GO:0005681 ! spliceosome + +[Term] +id: GO:0005690 +name: snRNP U4atac +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U4atac; a component of the minor spliceosome complex." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005689 ! U12-dependent spliceosome + +[Term] +id: GO:0005691 +name: snRNP U6atac +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U6atac; a component of the minor spliceosome complex." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005689 ! U12-dependent spliceosome + +[Term] +id: GO:0005692 +name: snRNP U11 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U11; a component of the minor spliceosome complex." [GOC:krc] +synonym: "12S U11 snRNP" NARROW [] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005689 ! U12-dependent spliceosome + +[Term] +id: GO:0005693 +name: snRNP U12 +namespace: cellular_component +def: "Ribonucleoprotein complex containing small nuclear RNA U12; a component of the minor spliceosome complex." [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005689 ! U12-dependent spliceosome + +[Term] +id: GO:0005694 +name: chromosome +namespace: cellular_component +def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "chromatid" RELATED [] +synonym: "interphase chromosome" NARROW [] +synonym: "prophase chromosome" NARROW [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005695 +name: chromatid +namespace: cellular_component +def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. +is_obsolete: true +consider: GO:0000793 +consider: GO:0000794 +consider: GO:0005694 + +[Term] +id: GO:0005696 +name: telomere +namespace: cellular_component +def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11352055] +comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. +is_obsolete: true +consider: GO:0000781 +consider: GO:0000782 + +[Term] +id: GO:0005697 +name: telomerase holoenzyme complex +namespace: cellular_component +def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] +subset: goslim_pir +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0005698 +name: centromere +namespace: cellular_component +def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it is genetically defined region and not a specific subcellular localization. +is_obsolete: true +consider: GO:0000775 + +[Term] +id: GO:0005700 +name: polytene chromosome +namespace: cellular_component +def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0005701 +name: polytene chromosome chromocenter +namespace: cellular_component +def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] +synonym: "polytene chromosome chromocentre" EXACT [] +is_a: GO:0010369 ! chromocenter +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005702 +name: polytene chromosome weak point +namespace: cellular_component +def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] +synonym: "constriction" BROAD [] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005703 +name: polytene chromosome puff +namespace: cellular_component +def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005704 +name: polytene chromosome band +namespace: cellular_component +def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005705 +name: polytene chromosome interband +namespace: cellular_component +def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005706 +name: polytene chromosome ectopic fiber +namespace: cellular_component +def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] +synonym: "polytene chromosome ectopic fibre" EXACT [] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005707 +name: interphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0005694 + +[Term] +id: GO:0005708 +name: mitotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai] +comment: This term was made obsolete because it is based on a process. +is_obsolete: true +consider: GO:0000793 +consider: GO:0000794 + +[Term] +id: GO:0005709 +name: prophase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0005694 + +[Term] +id: GO:0005710 +name: metaphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +is_obsolete: true +consider: GO:0000793 +consider: GO:0000794 + +[Term] +id: GO:0005711 +name: meiotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai] +comment: This term was made obsolete because it is based on a process. +is_obsolete: true +consider: GO:0000794 + +[Term] +id: GO:0005712 +name: chiasma +namespace: cellular_component +def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0005713 +name: recombination nodule +namespace: cellular_component +def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0005714 +name: early recombination nodule +namespace: cellular_component +def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] +is_a: GO:0005713 ! recombination nodule + +[Term] +id: GO:0005715 +name: late recombination nodule +namespace: cellular_component +def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] +is_a: GO:0005713 ! recombination nodule + +[Term] +id: GO:0005719 +name: nuclear euchromatin +namespace: cellular_component +def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0000790 ! nuclear chromatin +is_a: GO:0000791 ! euchromatin + +[Term] +id: GO:0005720 +name: nuclear heterochromatin +namespace: cellular_component +def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0000790 ! nuclear chromatin +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0005721 +name: centromeric heterochromatin +namespace: cellular_component +def: "A region of heterochromatin located near the centromere of a chromosome." [PMID:12019236] +synonym: "centric heterochromatin" EXACT [] +is_a: GO:0000792 ! heterochromatin +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0005722 +name: beta-heterochromatin +namespace: cellular_component +def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] +is_a: GO:0005721 ! centromeric heterochromatin +relationship: part_of GO:0005701 ! polytene chromosome chromocenter + +[Term] +id: GO:0005723 +name: alpha-heterochromatin +namespace: cellular_component +def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] +is_a: GO:0005721 ! centromeric heterochromatin +relationship: part_of GO:0005701 ! polytene chromosome chromocenter + +[Term] +id: GO:0005724 +name: nuclear telomeric heterochromatin +namespace: cellular_component +def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] +is_a: GO:0005720 ! nuclear heterochromatin +is_a: GO:0031933 ! telomeric heterochromatin +relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region + +[Term] +id: GO:0005725 +name: intercalary heterochromatin +namespace: cellular_component +def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] +is_a: GO:0005720 ! nuclear heterochromatin + +[Term] +id: GO:0005726 +name: perichromatin fibrils +namespace: cellular_component +def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000790 ! nuclear chromatin + +[Term] +id: GO:0005727 +name: extrachromosomal circular DNA +namespace: cellular_component +def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] +subset: gosubset_prok +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0046821 ! extrachromosomal DNA + +[Term] +id: GO:0005728 +name: extrachromosomal rDNA circle +namespace: cellular_component +def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] +synonym: "extrachromosomal ribosomal DNA circle" EXACT [] +is_a: GO:0005727 ! extrachromosomal circular DNA + +[Term] +id: GO:0005729 +name: 2-micrometer circle DNA +namespace: cellular_component +def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] +is_a: GO:0005727 ! extrachromosomal circular DNA + +[Term] +id: GO:0005730 +name: nucleolus +namespace: cellular_component +def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0005731 +name: nucleolus organizer region +namespace: cellular_component +def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] +synonym: "NOR" EXACT [] +synonym: "nucleolus organiser region" EXACT [] +synonym: "nucleolus organizer complex" RELATED [] +is_a: GO:0030874 ! nucleolar chromatin +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0005732 +name: small nucleolar ribonucleoprotein complex +namespace: cellular_component +def: "A complex composed of RNA of the small nucleolar RNA (snoRNA) and protein, found in the nucleolus of a eukaryotic cell. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] +subset: goslim_pir +synonym: "small nucleolar ribonucleoprotein" EXACT [] +synonym: "snoRNP" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0005733 +name: small nucleolar RNA +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "snoRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005734 +name: box C + D snoRNP protein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0005735 +name: box H + ACA snoRNP protein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0005736 +name: DNA-directed RNA polymerase I complex +namespace: cellular_component +def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] +synonym: "DNA-directed RNA polymerase I activity" RELATED [] +is_a: GO:0044452 ! nucleolar part +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex + +[Term] +id: GO:0005737 +name: cytoplasm +namespace: cellular_component +def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005739 +name: mitochondrion +namespace: cellular_component +def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "mitochondria" EXACT [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005740 +name: mitochondrial envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] +subset: goslim_candida +subset: goslim_yeast +is_a: GO:0031967 ! organelle envelope +is_a: GO:0044429 ! mitochondrial part + +[Term] +id: GO:0005741 +name: mitochondrial outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] +synonym: "outer mitochondrial membrane" EXACT [] +is_a: GO:0031966 ! mitochondrial membrane +is_a: GO:0031968 ! organelle outer membrane + +[Term] +id: GO:0005742 +name: mitochondrial outer membrane translocase complex +namespace: cellular_component +def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] +synonym: "GIP complex" NARROW [] +synonym: "TOM complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0005743 +name: mitochondrial inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] +synonym: "inner mitochondrial membrane" EXACT [] +is_a: GO:0019866 ! organelle inner membrane +is_a: GO:0031966 ! mitochondrial membrane + +[Term] +id: GO:0005744 +name: mitochondrial inner membrane presequence translocase complex +namespace: cellular_component +def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +subset: goslim_pir +synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] +synonym: "mitochondrial inner membrane translocase complex" EXACT [] +synonym: "Tim23 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0005745 +name: m-AAA complex +namespace: cellular_component +def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [PMID:12417197] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0005746 +name: mitochondrial respiratory chain +namespace: cellular_component +def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. Complexes I, III and IV can transport protons if embedded in an oriented membrane, such as an intact mitochondrial inner membrane." [GOC:curators, ISBN:0198547684] +synonym: "mitochondrial electron transport chain" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0005747 +name: mitochondrial respiratory chain complex I +namespace: cellular_component +alt_id: GO:0005748 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "NADH dehydrogenase complex (ubiquinone) (sensu Eukaryota)" EXACT [] +synonym: "respiratory chain complex I (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045271 ! respiratory chain complex I +relationship: part_of GO:0005746 ! mitochondrial respiratory chain + +[Term] +id: GO:0005749 +name: mitochondrial respiratory chain complex II +namespace: cellular_component +alt_id: GO:0008136 +alt_id: GO:0009362 +alt_id: GO:0019738 +alt_id: GO:0030390 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "fumarate reductase complex (sensu Eukaryota)" EXACT [] +synonym: "mitochondrial fumarate reductase complex" EXACT [] +synonym: "respiratory chain complex II (sensu Eukaryota)" EXACT [] +synonym: "succinate dehydrogenase complex (sensu Eukaryota)" EXACT [] +synonym: "succinate dehydrogenase complex (ubiquinone) (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) +is_a: GO:0045283 ! fumarate reductase complex +relationship: part_of GO:0005746 ! mitochondrial respiratory chain + +[Term] +id: GO:0005750 +name: mitochondrial respiratory chain complex III +namespace: cellular_component +alt_id: GO:0015008 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "respiratory chain complex III (sensu Eukaryota)" EXACT [] +synonym: "ubiquinol-cytochrome c oxidoreductase complex (sensu Eukaryota)" EXACT [] +synonym: "ubiquinol-cytochrome-c reductase complex (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045275 ! respiratory chain complex III +relationship: part_of GO:0005746 ! mitochondrial respiratory chain + +[Term] +id: GO:0005751 +name: mitochondrial respiratory chain complex IV +namespace: cellular_component +alt_id: GO:0005752 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "cytochrome c oxidase complex (sensu Eukaryota)" EXACT [] +synonym: "respiratory chain complex IV (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045277 ! respiratory chain complex IV +relationship: part_of GO:0005746 ! mitochondrial respiratory chain + +[Term] +id: GO:0005753 +name: mitochondrial proton-transporting ATP synthase complex +namespace: cellular_component +alt_id: GO:0016470 +def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] +synonym: "hydrogen-translocating F-type ATPase complex (sensu Eukaryota)" EXACT [] +synonym: "hydrogen-transporting ATP synthase" BROAD [] +synonym: "proton-transporting ATP synthase complex (sensu Eukaryota)" EXACT [] +synonym: "respiratory chain complex V (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045259 ! proton-transporting ATP synthase complex +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0005754 +name: mitochondrial proton-transporting ATP synthase, catalytic core +namespace: cellular_component +def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, catalytic core (sensu Eukaryota)" EXACT [] +synonym: "proton-transporting ATP synthase, catalytic core (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core +relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0005755 +name: hydrogen-transporting ATP synthase, coupling factor CF(0) +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +is_obsolete: true +consider: GO:0045263 + +[Term] +id: GO:0005756 +name: mitochondrial proton-transporting ATP synthase, central stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, central stalk (sensu Eukaryota)" EXACT [] +synonym: "proton-transporting ATP synthase, central stalk (sensu Eukaryota)" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk +relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0005757 +name: mitochondrial permeability transition pore complex +namespace: cellular_component +def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol." [PMID:10393078] +synonym: "mitochondrial PT pore complex" EXACT [] +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0046930 ! pore complex +relationship: part_of GO:0005740 ! mitochondrial envelope + +[Term] +id: GO:0005758 +name: mitochondrial intermembrane space +namespace: cellular_component +alt_id: GO:0031971 +def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] +synonym: "mitochondrial envelope lumen" EXACT [] +synonym: "mitochondrial membrane lumen" RELATED [] +is_a: GO:0031970 ! organelle envelope lumen +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005740 ! mitochondrial envelope + +[Term] +id: GO:0005759 +name: mitochondrial matrix +namespace: cellular_component +def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty-acid oxidation." [GOC:as, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "mitochondrial stroma" NARROW [] +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0031980 ! mitochondrial lumen + +[Term] +id: GO:0005760 +name: gamma DNA polymerase complex +namespace: cellular_component +def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0005761 +name: mitochondrial ribosome +namespace: cellular_component +def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "55S ribosome, mitochondrial" NARROW [] +is_a: GO:0000313 ! organellar ribosome +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0005762 +name: mitochondrial large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] +synonym: "39S ribosomal subunit, mitochondrial" NARROW [] +is_a: GO:0000315 ! organellar large ribosomal subunit +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005761 ! mitochondrial ribosome + +[Term] +id: GO:0005763 +name: mitochondrial small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] +synonym: "28S ribosomal subunit, mitochondrial" NARROW [] +synonym: "mitochondrial ribosomal small subunit complex" EXACT [] +synonym: "mitochondrial ribosomal SSU complex" EXACT [] +is_a: GO:0000314 ! organellar small ribosomal subunit +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005761 ! mitochondrial ribosome + +[Term] +id: GO:0005764 +name: lysosome +namespace: cellular_component +def: "A cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_plant +is_a: GO:0000323 ! lytic vacuole + +[Term] +id: GO:0005765 +name: lysosomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0005766 +name: primary lysosome +namespace: cellular_component +def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0005767 +name: secondary lysosome +namespace: cellular_component +def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0005768 +name: endosome +namespace: cellular_component +def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005769 +name: early endosome +namespace: cellular_component +def: "Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered." [GOC:rb] +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0005770 +name: late endosome +namespace: cellular_component +def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [PMID:11964142, PMID:2557062] +synonym: "prevacuolar compartment" EXACT [] +synonym: "PVC" BROAD [] +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0005771 +name: multivesicular body +namespace: cellular_component +def: "A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881] +synonym: "multivesicular endosome" EXACT [PMID:12122203] +synonym: "MVB" EXACT [] +synonym: "MVE" EXACT [PMID:12122203] +is_a: GO:0005770 ! late endosome + +[Term] +id: GO:0005773 +name: vacuole +namespace: cellular_component +def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "vacuolar carboxypeptidase Y" RELATED [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005774 +name: vacuolar membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] +subset: gosubset_prok +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044437 ! vacuolar part + +[Term] +id: GO:0005775 +name: vacuolar lumen +namespace: cellular_component +def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0044437 ! vacuolar part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0005776 +name: autophagic vacuole +namespace: cellular_component +def: "A double-membrane-bounded vesicle in which endogenous cellular material is sequestered; known as autophagosome in yeast." [ISBN:0198547684, PMID:11099404] +synonym: "autophagosome" EXACT [] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0005777 +name: peroxisome +namespace: cellular_component +alt_id: GO:0019818 +def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0042579 ! microbody + +[Term] +id: GO:0005778 +name: peroxisomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] +synonym: "peroxisome membrane" EXACT [] +is_a: GO:0031903 ! microbody membrane +is_a: GO:0044439 ! peroxisomal part + +[Term] +id: GO:0005779 +name: integral to peroxisomal membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031231 ! intrinsic to peroxisomal membrane +is_a: GO:0031301 ! integral to organelle membrane + +[Term] +id: GO:0005780 +name: extrinsic to intraperoxisomal membrane +namespace: cellular_component +def: "Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region." [GOC:mah] +synonym: "intra-peroxisomal peripheral membrane" RELATED [] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044439 ! peroxisomal part +relationship: part_of GO:0005778 ! peroxisomal membrane + +[Term] +id: GO:0005781 +name: peroxisome targeting signal receptor complex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. +is_obsolete: true +consider: GO:0000268 +consider: GO:0006625 +consider: GO:0044439 + +[Term] +id: GO:0005782 +name: peroxisomal matrix +namespace: cellular_component +def: "The material contained within the membrane of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:mah, ISBN:0815316194] +is_a: GO:0044439 ! peroxisomal part + +[Term] +id: GO:0005783 +name: endoplasmic reticulum +namespace: cellular_component +def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "ER" EXACT [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005784 +name: translocon complex +namespace: cellular_component +def: "A translocation complex that constitutes the specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. Composed of a heterotetramer of alpha, beta, gamma and delta subunits (translocon-associated proteins or TRAPs). In yeast it is a heterotrimeric complex consisting of Sec61p, Sbh1p, and Sss1p. The Sec61 complex functions in cotranslational and posttranslational translocation events." [GOC:rb, ISBN:0198599471] +subset: goslim_pir +synonym: "sec61 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0005785 +name: signal recognition particle receptor complex +namespace: cellular_component +def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "docking protein complex" RELATED [] +synonym: "SR complex" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0005786 +name: signal recognition particle, endoplasmic reticulum targeting +namespace: cellular_component +alt_id: GO:0005855 +def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "signal recognition particle (sensu Eukaryota)" EXACT [] +synonym: "signal sequence receptor complex" EXACT [] +synonym: "SRP" EXACT [] +is_a: GO:0048500 ! signal recognition particle + +[Term] +id: GO:0005787 +name: signal peptidase complex +namespace: cellular_component +def: "A multi subunit protease complex located in the endoplasmic reticulum membrane that cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0005788 +name: endoplasmic reticulum lumen +namespace: cellular_component +alt_id: GO:0016022 +def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] +synonym: "cisternal lumen" EXACT [] +synonym: "endoplasmic reticulum cisterna" EXACT [] +synonym: "ER cisterna" EXACT [] +synonym: "ER lumen" EXACT [] +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0005789 +name: endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] +synonym: "ER membrane" EXACT [] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network + +[Term] +id: GO:0005790 +name: smooth endoplasmic reticulum +namespace: cellular_component +def: "The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "smooth ER" EXACT [] +is_a: GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0005791 +name: rough endoplasmic reticulum +namespace: cellular_component +def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "rough ER" EXACT [] +is_a: GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0005792 +name: microsome +namespace: cellular_component +def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +synonym: "microsomal membrane" RELATED [] +is_a: GO:0042598 ! vesicular fraction + +[Term] +id: GO:0005793 +name: ER-Golgi intermediate compartment +namespace: cellular_component +def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [PMID:16723730] +synonym: "endoplasmic reticulum-Golgi intermediate compartment" EXACT [] +synonym: "ERGIC" EXACT [] +synonym: "pre-Golgi intermediate compartment" EXACT [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005794 +name: Golgi apparatus +namespace: cellular_component +def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "Golgi" BROAD [] +synonym: "Golgi complex" EXACT [] +synonym: "Golgi ribbon" NARROW [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005795 +name: Golgi stack +namespace: cellular_component +alt_id: GO:0016940 +def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] +synonym: "dictyosome" NARROW [] +synonym: "Golgi cisternae" EXACT [] +is_a: GO:0044431 ! Golgi apparatus part + +[Term] +id: GO:0005796 +name: Golgi lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah] +is_a: GO:0044431 ! Golgi apparatus part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0005797 +name: Golgi medial cisterna +namespace: cellular_component +def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] +is_a: GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0005798 +name: Golgi-associated vesicle +namespace: cellular_component +def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] +comment: Note that this definition includes vesicles that are transiently associated with the Golgi. +synonym: "Golgi vesicle" RELATED [] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle +is_a: GO:0044431 ! Golgi apparatus part + +[Term] +id: GO:0005799 +name: coatomer +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. +synonym: "COPI vesicle" RELATED [] +is_obsolete: true +consider: GO:0030126 +consider: GO:0030137 + +[Term] +id: GO:0005800 +name: COPII vesicle +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +is_obsolete: true +consider: GO:0030134 + +[Term] +id: GO:0005801 +name: cis-Golgi network +namespace: cellular_component +def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] +synonym: "cis Golgi network" EXACT [] +synonym: "forming face" RELATED [] +synonym: "Golgi cis face" RELATED [] +synonym: "Golgi cis-face" RELATED [] +is_a: GO:0044431 ! Golgi apparatus part + +[Term] +id: GO:0005802 +name: trans-Golgi network +namespace: cellular_component +def: "The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] +synonym: "Golgi trans face" RELATED [] +synonym: "Golgi trans-face" RELATED [] +synonym: "maturing face" RELATED [] +synonym: "TGN" EXACT [] +synonym: "trans Golgi network" EXACT [] +is_a: GO:0044431 ! Golgi apparatus part + +[Term] +id: GO:0005803 +name: secretory vesicle +namespace: cellular_component +def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684] +comment: This term was made obsolete because it was being used to describe two different components. +synonym: "transition vesicle" NARROW [] +is_obsolete: true +consider: GO:0030133 +consider: GO:0030141 + +[Term] +id: GO:0005804 +name: secretory vesicle membrane +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its parent was made obsolete. +is_obsolete: true +consider: GO:0030658 +consider: GO:0030667 + +[Term] +id: GO:0005805 +name: ER-Golgi transport vesicle +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +is_obsolete: true +consider: GO:0030134 + +[Term] +id: GO:0005806 +name: Golgi-ER transport vesicle +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +is_obsolete: true +consider: GO:0030142 + +[Term] +id: GO:0005808 +name: Golgi-plasma membrane transport vesicle +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. +is_obsolete: true +consider: GO:0030133 + +[Term] +id: GO:0005809 +name: Golgi-vacuole transport vesicle +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +is_obsolete: true +consider: GO:0030133 + +[Term] +id: GO:0005810 +name: endocytotic transport vesicle +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +is_obsolete: true +replaced_by: GO:0030139 + +[Term] +id: GO:0005811 +name: lipid particle +namespace: cellular_component +def: "Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins." [GOC:mah] +comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. +subset: goslim_generic +synonym: "adiposome" EXACT [] +synonym: "lipid body" EXACT [] +synonym: "lipid droplet" EXACT [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005813 +name: centrosome +namespace: cellular_component +def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] +subset: goslim_pir +is_a: GO:0005815 ! microtubule organizing center +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005814 +name: centriole +namespace: cellular_component +def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0005815 +name: microtubule organizing center +namespace: cellular_component +def: "A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [ISBN:0815316194] +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +synonym: "microtubule organising centre" EXACT [] +synonym: "MTOC" EXACT [] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005816 +name: spindle pole body +namespace: cellular_component +def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] +is_a: GO:0005815 ! microtubule organizing center +relationship: part_of GO:0000922 ! spindle pole + +[Term] +id: GO:0005817 +name: centrosomal mitotic factor +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt] +comment: This term was made obsolete because it was not defined. +is_obsolete: true + +[Term] +id: GO:0005818 +name: aster +namespace: cellular_component +def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0005819 +name: spindle +namespace: cellular_component +def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005821 +name: intermediate layer of spindle pole body +namespace: cellular_component +def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005822 +name: inner plaque of spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005823 +name: central plaque of spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005824 +name: outer plaque of spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005825 +name: half bridge of spindle pole body +namespace: cellular_component +def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005826 +name: contractile ring +namespace: cellular_component +alt_id: GO:0030480 +def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194] +synonym: "actomyosin ring" RELATED [] +synonym: "actomyosin ring (sensu Fungi)" NARROW [] +synonym: "CAR" EXACT [] +synonym: "constriction ring" RELATED [] +synonym: "contractile actomyosin ring" EXACT [] +synonym: "contractile ring (sensu Fungi)" NARROW [] +synonym: "cytokinetic ring (sensu Fungi)" NARROW [] +is_a: GO:0032155 ! cell division site part +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005827 +name: polar microtubule +namespace: cellular_component +def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] +synonym: "pole-to-pole microtubule" EXACT [] +is_a: GO:0005876 ! spindle microtubule +relationship: part_of GO:0000922 ! spindle pole + +[Term] +id: GO:0005828 +name: kinetochore microtubule +namespace: cellular_component +def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] +synonym: "pole-to-kinetochore microtubule" EXACT [] +is_a: GO:0005876 ! spindle microtubule + +[Term] +id: GO:0005829 +name: cytosol +namespace: cellular_component +def: "That part of the cytoplasm that does not contain membranous or particulate subcellular components." [ISBN:0198547684] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005831 +name: steroid hormone aporeceptor complex +namespace: cellular_component +def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0005832 +name: chaperonin-containing T-complex +namespace: cellular_component +def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] +synonym: "CCT particle" EXACT [] +synonym: "TriC" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0005833 +name: hemoglobin complex +namespace: cellular_component +def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "haemoglobin complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0005834 +name: heterotrimeric G-protein complex +namespace: cellular_component +def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] +comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'. +subset: gosubset_prok +synonym: "heterotrimeric G-protein GTPase activity" RELATED [] +synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] +synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] +synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] +is_a: GO:0019897 ! extrinsic to plasma membrane +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0005835 +name: fatty acid synthase complex +namespace: cellular_component +def: "A multienzyme complex required to convert carbohydrates to fatty acids, specifically acetyl CoA to palmitate." [GOC:sgd_curators, ISBN:0716746840] +subset: goslim_pir +subset: gosubset_prok +synonym: "FAS complex" EXACT [] +synonym: "fatty acid synthetase complex" EXACT [] +synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005836 +name: fatty-acyl-CoA synthase complex +namespace: cellular_component +def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] +comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0005837 +name: 26S proteasome +namespace: cellular_component +def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin moiety. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804] +comment: This term was made obsolete because its definition was inaccurate. +is_obsolete: true +consider: GO:0000502 + +[Term] +id: GO:0005838 +name: proteasome regulatory particle +namespace: cellular_component +def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome, GOC:rb] +synonym: "19S regulatory particle" NARROW [] +synonym: "PA700 proteasome activator" NARROW [] +synonym: "proteasome regulatory particle (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0022624 ! proteasome accessory complex + +[Term] +id: GO:0005839 +name: proteasome core complex +namespace: cellular_component +alt_id: GO:0000503 +def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] +synonym: "20S core complex" NARROW [] +synonym: "26S proteasome" NARROW [] +synonym: "macropain" EXACT [] +synonym: "proteasome core complex (sensu Bacteria)" EXACT [] +synonym: "proteasome core complex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0000502 ! proteasome complex + +[Term] +id: GO:0005840 +name: ribosome +namespace: cellular_component +def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "ribosomal RNA" RELATED [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005844 +name: polysome +namespace: cellular_component +def: "Several ribosomes bound to one mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +synonym: "polyribosome" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0005845 +name: mRNA cap binding complex +namespace: cellular_component +def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jic] +synonym: "mRNA cap complex" RELATED [] +is_a: GO:0034518 ! RNA cap binding complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005846 +name: nuclear cap binding complex +namespace: cellular_component +def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] +comment: Note that this complex can be found in the cytoplasm as well as the nucleus. +synonym: "CBC" RELATED [] +synonym: "mRNA cap binding complex" NARROW [] +synonym: "NCBP-NIP1 complex" NARROW [] +synonym: "snRNA cap binding complex" NARROW [] +is_a: GO:0034518 ! RNA cap binding complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005847 +name: mRNA cleavage and polyadenylation specificity factor complex +namespace: cellular_component +def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] +synonym: "CFII complex" RELATED [] +synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] +synonym: "CPF complex" NARROW [] +synonym: "CPSF complex" NARROW [] +is_a: GO:0005849 ! mRNA cleavage factor complex + +[Term] +id: GO:0005848 +name: mRNA cleavage stimulating factor complex +namespace: cellular_component +def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] +synonym: "cleavage stimulation factor activity" RELATED [] +synonym: "CstF complex" NARROW [] +is_a: GO:0005849 ! mRNA cleavage factor complex + +[Term] +id: GO:0005849 +name: mRNA cleavage factor complex +namespace: cellular_component +def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0005850 +name: eukaryotic translation initiation factor 2 complex +namespace: cellular_component +def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] +synonym: "eIF-2" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005851 +name: eukaryotic translation initiation factor 2B complex +namespace: cellular_component +def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] +synonym: "eIF-2B" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005852 +name: eukaryotic translation initiation factor 3 complex +namespace: cellular_component +def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex." [PMID:15904532] +synonym: "eIF-3" EXACT [] +synonym: "eIF3" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005853 +name: eukaryotic translation elongation factor 1 complex +namespace: cellular_component +def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950, UniProtKB:P24534] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005854 +name: nascent polypeptide-associated complex +namespace: cellular_component +def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] +synonym: "NAC" EXACT [] +synonym: "NACA" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005856 +name: cytoskeleton +namespace: cellular_component +def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005858 +name: axonemal dynein complex +namespace: cellular_component +def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which in converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194] +synonym: "axonemal dynein heavy chain" NARROW [] +synonym: "axonemal dynein intermediate chain" NARROW [] +synonym: "axonemal dynein intermediate light chain" NARROW [] +synonym: "axonemal dynein light chain" NARROW [] +is_a: GO:0030286 ! dynein complex +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0005859 +name: muscle myosin complex +namespace: cellular_component +def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] +is_a: GO:0016460 ! myosin II complex +is_a: GO:0044449 ! contractile fiber part + +[Term] +id: GO:0005861 +name: troponin complex +namespace: cellular_component +def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0005865 ! striated muscle thin filament + +[Term] +id: GO:0005862 +name: muscle thin filament tropomyosin +namespace: cellular_component +def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0005865 ! striated muscle thin filament + +[Term] +id: GO:0005863 +name: striated muscle thick filament +namespace: cellular_component +def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] +is_a: GO:0005859 ! muscle myosin complex +is_a: GO:0032982 ! myosin filament +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0005865 +name: striated muscle thin filament +namespace: cellular_component +def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0015629 ! actin cytoskeleton +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0005868 +name: cytoplasmic dynein complex +namespace: cellular_component +def: "Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311] +synonym: "cytoplasmic dynein heavy chain" NARROW [] +synonym: "cytoplasmic dynein intermediate chain" NARROW [] +synonym: "cytoplasmic dynein intermediate light chain" NARROW [] +synonym: "cytoplasmic dynein light chain" NARROW [] +is_a: GO:0030286 ! dynein complex + +[Term] +id: GO:0005869 +name: dynactin complex +namespace: cellular_component +def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005875 ! microtubule associated complex +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005870 +name: actin capping protein of dynactin complex +namespace: cellular_component +def: "A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, UniProtKB:P14315] +is_a: GO:0008290 ! F-actin capping protein complex +relationship: part_of GO:0005869 ! dynactin complex + +[Term] +id: GO:0005871 +name: kinesin complex +namespace: cellular_component +def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] +is_a: GO:0005875 ! microtubule associated complex + +[Term] +id: GO:0005872 +name: minus-end kinesin complex +namespace: cellular_component +def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0005873 +name: plus-end kinesin complex +namespace: cellular_component +def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0005874 +name: microtubule +namespace: cellular_component +def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005875 +name: microtubule associated complex +namespace: cellular_component +def: "Any multimeric complex connected to a microtubule." [GOC:jl] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005876 +name: spindle microtubule +namespace: cellular_component +def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0005879 +name: axonemal microtubule +namespace: cellular_component +def: "A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [ISBN:0815316194] +is_a: GO:0005874 ! microtubule +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0005880 +name: nuclear microtubule +namespace: cellular_component +def: "Any microtubule in the nucleus of a cell." [GOC:mah] +is_a: GO:0005874 ! microtubule +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0005881 +name: cytoplasmic microtubule +namespace: cellular_component +def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] +synonym: "non-spindle-associated astral microtubule" NARROW [] +is_a: GO:0005874 ! microtubule + +[Term] +id: GO:0005882 +name: intermediate filament +namespace: cellular_component +def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "intermediate filament associated protein" RELATED [] +synonym: "type I intermediate filament associated protein" RELATED [] +synonym: "type II intermediate filament associated protein" RELATED [] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0045111 ! intermediate filament cytoskeleton + +[Term] +id: GO:0005883 +name: neurofilament +namespace: cellular_component +def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363, ISBN:0815316194] +synonym: "type IV intermediate filament" EXACT [] +is_a: GO:0005882 ! intermediate filament +relationship: part_of GO:0060053 ! neurofilament cytoskeleton + +[Term] +id: GO:0005884 +name: actin filament +namespace: cellular_component +def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10666339] +synonym: "microfilament" BROAD [] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005885 +name: Arp2/3 protein complex +namespace: cellular_component +def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005886 +name: plasma membrane +namespace: cellular_component +def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "bacterial inner membrane" NARROW [] +synonym: "cell membrane" EXACT [] +synonym: "cytoplasmic membrane" EXACT [] +synonym: "inner endospore membrane" NARROW [] +synonym: "juxtamembrane" BROAD [] +synonym: "plasmalemma" EXACT [] +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0005887 +name: integral to plasma membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0016021 ! integral to membrane +is_a: GO:0031226 ! intrinsic to plasma membrane + +[Term] +id: GO:0005888 +name: proteoglycan integral to plasma membrane +namespace: cellular_component +def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. +is_obsolete: true +replaced_by: GO:0005887 + +[Term] +id: GO:0005889 +name: hydrogen:potassium-exchanging ATPase complex +namespace: cellular_component +def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of Na+ and K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] +synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] +synonym: "proton pump" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005890 +name: sodium:potassium-exchanging ATPase complex +namespace: cellular_component +def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "sodium pump" BROAD [] +synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005891 +name: voltage-gated calcium channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] +subset: goslim_pir +synonym: "voltage gated calcium channel complex" EXACT [] +synonym: "voltage-dependent calcium channel complex" EXACT [] +synonym: "voltage-sensitive calcium channel complex" EXACT [] +is_a: GO:0034704 ! calcium channel complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0005892 +name: nicotinic acetylcholine-gated receptor-channel complex +namespace: cellular_component +def: "A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily." [GOC:mah, PMID:12381728, PMID:15579462] +synonym: "nicotinic acetylcholine receptor" BROAD [] +is_a: GO:0034702 ! ion channel complex +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005893 +name: interleukin-2 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005894 +name: interleukin-3 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005895 +name: interleukin-5 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005896 +name: interleukin-6 receptor complex +namespace: cellular_component +def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005897 +name: interleukin-9 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005898 +name: interleukin-13 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-4 receptor alpha chain and interleukin-4 receptor alpha chain." [UniProtKB:P78552] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005899 +name: insulin receptor complex +namespace: cellular_component +def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005900 +name: oncostatin-M receptor complex +namespace: cellular_component +def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0005901 +name: caveola +namespace: cellular_component +alt_id: GO:0016599 +def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the cell membrane formed during pinocytosis, that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "caveolae" EXACT [] +synonym: "caveolar membrane" RELATED [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045121 ! membrane raft + +[Term] +id: GO:0005902 +name: microvillus +namespace: cellular_component +def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] +comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. +subset: goslim_pir +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0005903 +name: brush border +namespace: cellular_component +def: "Dense covering of microvilli on the apical surface of epithelial cells in the intestine and kidney; the microvilli aid absorption by increasing the surface area of the cell." [ISBN:0815316194] +subset: goslim_pir +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0005904 +name: plasma membrane lipid bilayer +namespace: cellular_component +def: "The phospholipid membrane surrounding a cell that separates the cell from its external environment, excluding intergral and associated proteins." [GOC:go_curators] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0005905 +name: coated pit +namespace: cellular_component +def: "An invagination of the cell membrane of many eukaryotic cells, concerned in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane. During endocytosis it is converted into a coated vesicle. The coat is of clathrin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0005906 +name: clathrin adaptor +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. +synonym: "adaptin" RELATED [] +is_obsolete: true +replaced_by: GO:0030119 + +[Term] +id: GO:0005907 +name: HA1 clathrin adaptor +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. +synonym: "AP1" RELATED [] +is_obsolete: true +consider: GO:0030121 + +[Term] +id: GO:0005908 +name: HA2 clathrin adaptor +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. +synonym: "AP2" RELATED [] +is_obsolete: true +consider: GO:0030122 + +[Term] +id: GO:0005911 +name: cell-cell junction +namespace: cellular_component +def: "A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] +synonym: "intercellular junction" EXACT [] +is_a: GO:0030054 ! cell junction + +[Term] +id: GO:0005912 +name: adherens junction +namespace: cellular_component +def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0070161 ! anchoring junction + +[Term] +id: GO:0005913 +name: cell-cell adherens junction +namespace: cellular_component +def: "An adherens junction which connects two cells to each other." [GOC:hb] +is_a: GO:0005911 ! cell-cell junction +is_a: GO:0005912 ! adherens junction + +[Term] +id: GO:0005914 +name: spot adherens junction +namespace: cellular_component +def: "A small junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] +synonym: "dense plaque" BROAD [] +synonym: "punctum adherens" EXACT [] +is_a: GO:0005913 ! cell-cell adherens junction + +[Term] +id: GO:0005915 +name: zonula adherens +namespace: cellular_component +def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] +synonym: "adhesion belt" EXACT [] +synonym: "belt desmosome" EXACT [] +synonym: "intermediate junction" EXACT [] +is_a: GO:0005913 ! cell-cell adherens junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0005916 +name: fascia adherens +namespace: cellular_component +def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, PMID:11732910] +is_a: GO:0005913 ! cell-cell adherens junction +relationship: part_of GO:0014704 ! intercalated disc + +[Term] +id: GO:0005917 +name: nephrocyte junction +namespace: cellular_component +def: "A tissue-specific adherens junction found in kidney cells." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] +is_a: GO:0005913 ! cell-cell adherens junction + +[Term] +id: GO:0005918 +name: septate junction +namespace: cellular_component +def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] +synonym: "septate desmosome" RELATED [] +is_a: GO:0070160 ! occluding junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0005919 +name: pleated septate junction +namespace: cellular_component +def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] +synonym: "pleated desmosome" RELATED [] +is_a: GO:0005918 ! septate junction + +[Term] +id: GO:0005920 +name: smooth septate junction +namespace: cellular_component +def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] +synonym: "zonula continua" EXACT [] +is_a: GO:0005918 ! septate junction + +[Term] +id: GO:0005921 +name: gap junction +namespace: cellular_component +def: "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2Ð4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] +synonym: "communicating junction" EXACT [] +synonym: "macula communicans" EXACT [] +synonym: "zonula communicans" EXACT [] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0005922 +name: connexon complex +namespace: cellular_component +def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005921 ! gap junction + +[Term] +id: GO:0005923 +name: tight junction +namespace: cellular_component +def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] +synonym: "zonula occludens" EXACT [] +is_a: GO:0070160 ! occluding junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0005924 +name: cell-substrate adherens junction +namespace: cellular_component +def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] +synonym: "hemi-adherens junction" RELATED [] +is_a: GO:0005912 ! adherens junction +is_a: GO:0030055 ! cell-substrate junction + +[Term] +id: GO:0005925 +name: focal adhesion +namespace: cellular_component +alt_id: GO:0008357 +def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] +synonym: "focal contact" EXACT [] +synonym: "hemi-adherens junction" RELATED [] +is_a: GO:0005924 ! cell-substrate adherens junction + +[Term] +id: GO:0005926 +name: connecting hemi-adherens junction +namespace: cellular_component +def: "A hemiadherens junction (HAJ) that forms one of a pair of HAJs in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] +is_a: GO:0005924 ! cell-substrate adherens junction + +[Term] +id: GO:0005927 +name: muscle tendon junction +namespace: cellular_component +def: "Terminal anchorage site of skeletal muscle cells to tendons; a specialised type of contact between the cell and the extracellular matrix in skeletal muscle." [GOC:mtg_muscle, PMID:12842007] +synonym: "myotendinous junction" EXACT [] +is_a: GO:0005924 ! cell-substrate adherens junction + +[Term] +id: GO:0005928 +name: apical hemi-adherens junction +namespace: cellular_component +def: "An adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] +synonym: "apical dense plaque" EXACT [] +is_a: GO:0005924 ! cell-substrate adherens junction + +[Term] +id: GO:0005929 +name: cilium +namespace: cellular_component +def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, ISBN:0198547684] +subset: goslim_generic +subset: goslim_pir +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0005930 +name: axoneme +namespace: cellular_component +def: "The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [ISBN:0198547684] +is_a: GO:0044422 ! organelle part +is_a: GO:0044424 ! intracellular part +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0005931 +name: nexin complex +namespace: cellular_component +def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0005932 +name: basal body +namespace: cellular_component +def: "A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth." [GOC:clt] +is_a: GO:0005815 ! microtubule organizing center +is_a: GO:0044463 ! cell projection part + +[Term] +id: GO:0005933 +name: cellular bud +namespace: cellular_component +def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0005934 +name: cellular bud tip +namespace: cellular_component +def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] +is_a: GO:0030427 ! site of polarized growth +relationship: part_of GO:0005933 ! cellular bud + +[Term] +id: GO:0005935 +name: cellular bud neck +namespace: cellular_component +def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] +is_a: GO:0030427 ! site of polarized growth +relationship: part_of GO:0005933 ! cellular bud + +[Term] +id: GO:0005936 +name: shmoo +namespace: cellular_component +def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc] +comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'. +is_obsolete: true +consider: GO:0001400 +consider: GO:0005937 + +[Term] +id: GO:0005937 +name: mating projection +namespace: cellular_component +def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] +subset: goslim_pir +synonym: "conjugation tube" NARROW [] +synonym: "shmoo" NARROW [] +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0005938 +name: cell cortex +namespace: cellular_component +def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] +subset: goslim_candida +subset: goslim_yeast +synonym: "cell periphery" RELATED [] +synonym: "peripheral cytoplasm" RELATED [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005940 +name: septin ring +namespace: cellular_component +alt_id: GO:0030481 +def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] +synonym: "septin ring (sensu Fungi)" NARROW [] +is_a: GO:0032156 ! septin cytoskeleton +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part + +[Term] +id: GO:0005941 +name: unlocalized protein complex +namespace: cellular_component +def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma] +comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed. +is_obsolete: true + +[Term] +id: GO:0005942 +name: phosphoinositide 3-kinase complex +namespace: cellular_component +def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K)." [GOC:bf] +subset: goslim_pir +synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] +synonym: "PI3K complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0005943 +name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex +namespace: cellular_component +alt_id: GO:0035030 +def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] +synonym: "class IA PI3K complex" EXACT [] +synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] +is_a: GO:0005942 ! phosphoinositide 3-kinase complex + +[Term] +id: GO:0005944 +name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex +namespace: cellular_component +alt_id: GO:0035031 +def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] +synonym: "class IB PI3K complex" EXACT [] +synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] +is_a: GO:0005942 ! phosphoinositide 3-kinase complex + +[Term] +id: GO:0005945 +name: 6-phosphofructokinase complex +namespace: cellular_component +def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0005946 +name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) +namespace: cellular_component +def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] +comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. +synonym: "trehalose-6-phosphate synthase complex" EXACT [] +synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] +synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005947 +name: mitochondrial alpha-ketoglutarate dehydrogenase complex +namespace: cellular_component +def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] +synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] +synonym: "alpha-ketoglutarate dehydrogenase complex (sensu Eukaryota)" EXACT [] +is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex +is_a: GO:0045240 ! alpha-ketoglutarate dehydrogenase complex + +[Term] +id: GO:0005948 +name: acetolactate synthase complex +namespace: cellular_component +def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, UniProtKB:P37252] +comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. +subset: gosubset_prok +synonym: "acetohydroxyacid synthase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005949 +name: aminoadipate-semialdehyde dehydrogenase complex +namespace: cellular_component +def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31, UniProtKB:Q12572] +comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products. +is_obsolete: true + +[Term] +id: GO:0005950 +name: anthranilate synthase complex +namespace: cellular_component +def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, UniProtKB:P09785] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005951 +name: carbamoyl-phosphate synthase complex +namespace: cellular_component +def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] +comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. +subset: gosubset_prok +synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] +synonym: "carbamoyl phosphate synthase complex" EXACT [] +synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005952 +name: cAMP-dependent protein kinase complex +namespace: cellular_component +def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] +synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] +synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] +synonym: "PKA" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005953 +name: CAAX-protein geranylgeranyltransferase complex +namespace: cellular_component +def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874, UniProtKB:P53609] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005954 +name: calcium- and calmodulin-dependent protein kinase complex +namespace: cellular_component +def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17, UniProtKB:Q9UQM7] +synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] +synonym: "CAMK2" EXACT [] +synonym: "CaMKII" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005955 +name: calcineurin complex +namespace: cellular_component +def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951] +synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] +synonym: "protein phosphatase type 2B complex" EXACT [] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005956 +name: protein kinase CK2 complex +namespace: cellular_component +def: "Complex that possesses casein kinase activity, found in nearly every subcellular compartment. Protein kinase CK2 complexes are usually tetramers of two alpha and two beta subunits, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. One function possessed by this complex is represented by the molecular function term 'casein kinase II ; GO:0004682'. +synonym: "casein kinase II complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005957 +name: debranching enzyme +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. +is_obsolete: true +consider: GO:0043033 + +[Term] +id: GO:0005958 +name: DNA-dependent protein kinase complex +namespace: cellular_component +alt_id: GO:0005959 +def: "A large protein complex which is involved in the repair of DNA double-strand breaks and V(D)J recombination events. In mammals, it consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer, Ku, the nuclear phosphoprotein XRCC4 and DNA ligase IV." [GOC:jl, PMID:10854421, PMID:12235392] +synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW [] +synonym: "DNA-PK complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0005960 +name: glycine cleavage complex +namespace: cellular_component +alt_id: GO:0005961 +def: "A multienzyme complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase." [MetaCyc:GCVMULTI-CPLX] +subset: goslim_pir +subset: gosubset_prok +synonym: "glycine cleavage system" EXACT [] +synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] +synonym: "glycine synthase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005962 +name: mitochondrial isocitrate dehydrogenase complex (NAD+) +namespace: cellular_component +def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. +synonym: "isocitrate dehydrogenase complex (NAD+) (sensu Eukaryota)" EXACT [] +is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex +is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) + +[Term] +id: GO:0005963 +name: magnesium-dependent protein serine/threonine phosphatase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0005964 +name: phosphorylase kinase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005965 +name: protein farnesyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005966 +name: cyclic-nucleotide phosphodiesterase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] +synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0005967 +name: mitochondrial pyruvate dehydrogenase complex +namespace: cellular_component +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. +synonym: "pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)" EXACT [] +synonym: "pyruvate dehydrogenase complex (sensu Eukaryota)" EXACT [] +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0045254 ! pyruvate dehydrogenase complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0005968 +name: Rab-protein geranylgeranyltransferase complex +namespace: cellular_component +def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217, UniProtKB:Q08602] +synonym: "GGTase-II complex" EXACT [] +synonym: "Rab geranylgeranyltransferase complex" EXACT [] +synonym: "RAB-protein geranylgeranyltransferase complex" EXACT [] +synonym: "RabGGTase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005969 +name: serine-pyruvate aminotransferase complex +namespace: cellular_component +alt_id: GO:0005970 +def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] +synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] +synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005971 +name: ribonucleoside-diphosphate reductase complex +namespace: cellular_component +def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin." [BRENDA:1.17.4.1] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0005972 +name: fibrinogen alpha chain +namespace: cellular_component +alt_id: GO:0008005 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +consider: GO:0005577 + +[Term] +id: GO:0005973 +name: fibrinogen beta chain +namespace: cellular_component +alt_id: GO:0008006 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +consider: GO:0005577 + +[Term] +id: GO:0005974 +name: fibrinogen gamma chain +namespace: cellular_component +alt_id: GO:0008007 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +consider: GO:0005577 + +[Term] +id: GO:0005975 +name: carbohydrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "carbohydrate metabolism" EXACT [] +xref: Reactome:211962 +xref: Reactome:221727 +xref: Reactome:230309 +xref: Reactome:238347 +xref: Reactome:244905 +xref: Reactome:249798 +xref: Reactome:252538 +xref: Reactome:255716 +xref: Reactome:259109 +xref: Reactome:262468 +xref: Reactome:265303 +xref: Reactome:268427 +xref: Reactome:274144 +xref: Reactome:280617 +xref: Reactome:282867 +xref: Reactome:286632 +xref: Reactome:288323 +xref: Reactome:289858 +xref: Reactome:290396 +xref: Reactome:291760 +xref: Reactome:292414 +xref: Reactome:293735 +xref: Reactome:71387 +is_a: GO:0044238 ! primary metabolic process + +[Term] +id: GO:0005976 +name: polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polysaccharides, a polymer of more than 10 monosaccharide residues joined by glycosidic linkages." [ISBN:0198547684] +subset: goslim_pir +subset: gosubset_prok +synonym: "glycan metabolic process" EXACT [] +synonym: "glycan metabolism" EXACT [] +synonym: "polysaccharide metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0043283 ! biopolymer metabolic process + +[Term] +id: GO:0005977 +name: glycogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycogen metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process +is_a: GO:0006112 ! energy reserve metabolic process + +[Term] +id: GO:0005978 +name: glycogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycogen anabolism" EXACT [] +synonym: "glycogen biosynthesis" EXACT [] +synonym: "glycogen formation" EXACT [] +synonym: "glycogen synthesis" EXACT [] +xref: MetaCyc:GLYCOGENSYNTH-PWY +xref: Reactome:211986 +xref: Reactome:221750 +xref: Reactome:230331 +xref: Reactome:238368 +xref: Reactome:244923 +xref: Reactome:249811 +xref: Reactome:252551 +xref: Reactome:255728 +xref: Reactome:259121 +xref: Reactome:262479 +xref: Reactome:265310 +xref: Reactome:268440 +xref: Reactome:274153 +xref: Reactome:280626 +xref: Reactome:282857 +xref: Reactome:286645 +xref: Reactome:291768 +xref: Reactome:292418 +xref: Reactome:293744 +xref: Reactome:70302 +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009250 ! glucan biosynthetic process + +[Term] +id: GO:0005979 +name: regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of glycogen anabolism" EXACT [] +synonym: "regulation of glycogen biosynthesis" EXACT [] +synonym: "regulation of glycogen formation" EXACT [] +synonym: "regulation of glycogen synthesis" EXACT [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0005978 ! glycogen biosynthetic process + +[Term] +id: GO:0005980 +name: glycogen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycogen breakdown" EXACT [] +synonym: "glycogen catabolism" EXACT [] +synonym: "glycogen degradation" EXACT [] +xref: MetaCyc:GLYCOCAT-PWY +xref: Reactome:211812 +xref: Reactome:221578 +xref: Reactome:230179 +xref: Reactome:238214 +xref: Reactome:244793 +xref: Reactome:249694 +xref: Reactome:252467 +xref: Reactome:255629 +xref: Reactome:259022 +xref: Reactome:262390 +xref: Reactome:265227 +xref: Reactome:268352 +xref: Reactome:274062 +xref: Reactome:280537 +xref: Reactome:282814 +xref: Reactome:286554 +xref: Reactome:291720 +xref: Reactome:292384 +xref: Reactome:293699 +xref: Reactome:70221 +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009251 ! glucan catabolic process + +[Term] +id: GO:0005981 +name: regulation of glycogen catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of glycogen breakdown" EXACT [] +synonym: "regulation of glycogen catabolism" EXACT [] +synonym: "regulation of glycogen degradation" EXACT [] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0005980 ! glycogen catabolic process + +[Term] +id: GO:0005982 +name: starch metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "starch metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process + +[Term] +id: GO:0005983 +name: starch catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] +subset: gosubset_prok +synonym: "starch breakdown" EXACT [] +synonym: "starch catabolism" EXACT [] +synonym: "starch degradation" EXACT [] +xref: MetaCyc:PWY-842 +is_a: GO:0005982 ! starch metabolic process +is_a: GO:0009251 ! glucan catabolic process + +[Term] +id: GO:0005984 +name: disaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X] +subset: gosubset_prok +synonym: "disaccharide metabolism" EXACT [] +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0005985 +name: sucrose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] +subset: gosubset_prok +synonym: "sucrose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005986 +name: sucrose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] +subset: gosubset_prok +synonym: "sucrose anabolism" EXACT [] +synonym: "sucrose biosynthesis" EXACT [] +synonym: "sucrose formation" EXACT [] +synonym: "sucrose synthesis" EXACT [] +xref: MetaCyc:SUCSYN-PWY +is_a: GO:0005985 ! sucrose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0005987 +name: sucrose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] +subset: gosubset_prok +synonym: "sucrose breakdown" EXACT [] +synonym: "sucrose catabolism" EXACT [] +synonym: "sucrose degradation" EXACT [] +is_a: GO:0005985 ! sucrose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005988 +name: lactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005989 +name: lactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactose anabolism" EXACT [] +synonym: "lactose biosynthesis" EXACT [] +synonym: "lactose formation" EXACT [] +synonym: "lactose synthesis" EXACT [] +is_a: GO:0005988 ! lactose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0005990 +name: lactose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactose breakdown" EXACT [] +synonym: "lactose catabolism" EXACT [] +synonym: "lactose degradation" EXACT [] +xref: MetaCyc:GALACTOGLUCAT-PWY +is_a: GO:0005988 ! lactose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005991 +name: trehalose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] +subset: gosubset_prok +synonym: "mycose metabolic process" EXACT [] +synonym: "mycose metabolism" EXACT [] +synonym: "mykose metabolic process" EXACT [] +synonym: "mykose metabolism" EXACT [] +synonym: "trehalose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005992 +name: trehalose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] +subset: gosubset_prok +synonym: "mycose biosynthesis" EXACT [] +synonym: "mycose biosynthetic process" EXACT [] +synonym: "mykose biosynthesis" EXACT [] +synonym: "mykose biosynthetic process" EXACT [] +synonym: "trehalose anabolism" EXACT [] +synonym: "trehalose biosynthesis" EXACT [] +synonym: "trehalose formation" EXACT [] +synonym: "trehalose synthesis" EXACT [] +xref: MetaCyc:PWY-881 +xref: MetaCyc:TREHALOSESYN-PWY +xref: MetaCyc:TRESYN-PWY +is_a: GO:0005991 ! trehalose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0005993 +name: trehalose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] +subset: gosubset_prok +synonym: "mycose catabolic process" EXACT [] +synonym: "mycose catabolism" EXACT [] +synonym: "mykose catabolic process" EXACT [] +synonym: "mykose catabolism" EXACT [] +synonym: "trehalose breakdown" EXACT [] +synonym: "trehalose catabolism" EXACT [] +synonym: "trehalose degradation" EXACT [] +xref: MetaCyc:TREDEGLOW-PWY +is_a: GO:0005991 ! trehalose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005994 +name: melibiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] +subset: gosubset_prok +synonym: "melibiose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005995 +name: melibiose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] +subset: gosubset_prok +synonym: "melibiose breakdown" EXACT [] +synonym: "melibiose catabolism" EXACT [] +synonym: "melibiose degradation" EXACT [] +is_a: GO:0005994 ! melibiose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005996 +name: monosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "monosaccharide metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0005997 +name: xylulose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] +subset: gosubset_prok +synonym: "xylulose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0005998 +name: xylulose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] +subset: gosubset_prok +synonym: "xylulose breakdown" EXACT [] +synonym: "xylulose catabolism" EXACT [] +synonym: "xylulose degradation" EXACT [] +xref: MetaCyc:XYLCAT-PWY +is_a: GO:0005997 ! xylulose metabolic process +is_a: GO:0019323 ! pentose catabolic process + +[Term] +id: GO:0005999 +name: xylulose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] +subset: gosubset_prok +synonym: "xylulose anabolism" EXACT [] +synonym: "xylulose biosynthesis" EXACT [] +synonym: "xylulose formation" EXACT [] +synonym: "xylulose synthesis" EXACT [] +xref: Reactome:163754 +xref: Reactome:211746 +xref: Reactome:221513 +xref: Reactome:230133 +xref: Reactome:238159 +xref: Reactome:244748 +xref: Reactome:249655 +xref: Reactome:252438 +xref: Reactome:255604 +xref: Reactome:258984 +xref: Reactome:262354 +xref: Reactome:265202 +xref: Reactome:268323 +xref: Reactome:274022 +xref: Reactome:280500 +xref: Reactome:282796 +xref: Reactome:286521 +xref: Reactome:288260 +xref: Reactome:289804 +xref: Reactome:290353 +xref: Reactome:291710 +xref: Reactome:292377 +xref: Reactome:293688 +is_a: GO:0005997 ! xylulose metabolic process +is_a: GO:0019322 ! pentose biosynthetic process + +[Term] +id: GO:0006000 +name: fructose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fructose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006001 +name: fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] +subset: gosubset_prok +synonym: "fructose breakdown" EXACT [] +synonym: "fructose catabolism" EXACT [] +synonym: "fructose degradation" EXACT [] +xref: Reactome:211677 +xref: Reactome:221448 +xref: Reactome:238100 +xref: Reactome:244706 +xref: Reactome:258954 +xref: Reactome:280473 +xref: Reactome:70350 +is_a: GO:0006000 ! fructose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0006002 +name: fructose 6-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fructose 6-phosphate metabolism" EXACT [] +is_a: GO:0006000 ! fructose metabolic process + +[Term] +id: GO:0006003 +name: fructose 2,6-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fructose 2,6-bisphosphate metabolism" EXACT [] +is_a: GO:0006000 ! fructose metabolic process + +[Term] +id: GO:0006004 +name: fucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fucose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006005 +name: L-fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl] +subset: gosubset_prok +synonym: "L-fucose anabolism" EXACT [] +synonym: "L-fucose biosynthesis" EXACT [] +synonym: "L-fucose formation" EXACT [] +synonym: "L-fucose synthesis" EXACT [] +is_a: GO:0042353 ! fucose biosynthetic process +is_a: GO:0042354 ! L-fucose metabolic process + +[Term] +id: GO:0006006 +name: glucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucose metabolism" EXACT [] +xref: Reactome:212005 +xref: Reactome:221769 +xref: Reactome:230348 +xref: Reactome:238386 +xref: Reactome:244941 +xref: Reactome:249822 +xref: Reactome:252560 +xref: Reactome:255738 +xref: Reactome:259132 +xref: Reactome:262489 +xref: Reactome:265318 +xref: Reactome:268449 +xref: Reactome:274168 +xref: Reactome:280641 +xref: Reactome:282865 +xref: Reactome:286658 +xref: Reactome:288373 +xref: Reactome:289878 +xref: Reactome:290410 +xref: Reactome:291774 +xref: Reactome:292428 +xref: Reactome:293750 +xref: Reactome:70326 +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006007 +name: glucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] +subset: gosubset_prok +synonym: "glucose breakdown" EXACT [] +synonym: "glucose catabolism" EXACT [] +synonym: "glucose degradation" EXACT [] +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0006008 +name: glucose 1-phosphate utilization +namespace: biological_process +subset: gosubset_prok +is_a: GO:0019255 ! glucose 1-phosphate metabolic process + +[Term] +id: GO:0006009 +name: glucose 1-phosphate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0019255 ! glucose 1-phosphate metabolic process +is_a: GO:0046835 ! carbohydrate phosphorylation + +[Term] +id: GO:0006010 +name: glucose 6-phosphate utilization +namespace: biological_process +subset: gosubset_prok +is_a: GO:0051156 ! glucose 6-phosphate metabolic process + +[Term] +id: GO:0006011 +name: UDP-glucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-glucose metabolism" EXACT [] +xref: MetaCyc:P61-PWY +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0006012 +name: galactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactose metabolism" EXACT [] +xref: MetaCyc:GALACTMETAB-PWY +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006013 +name: mannose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannose metabolism" EXACT [] +xref: MetaCyc:MANGDPMET-PWY +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006014 +name: D-ribose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-ribose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0006015 +name: 5-phosphoribose 1-diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] +subset: gosubset_prok +synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT [] +synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT [] +synonym: "5-phosphoribose 1-diphosphate formation" EXACT [] +synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT [] +synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT [] +synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT [] +synonym: "PRPP biosynthetic process" EXACT [] +xref: MetaCyc:PWY0-661 +is_a: GO:0046390 ! ribose phosphate biosynthetic process +is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process + +[Term] +id: GO:0006016 +name: 2-deoxyribose 1-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "2-deoxyribose 1-phosphate anabolism" EXACT [] +synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT [] +synonym: "2-deoxyribose 1-phosphate formation" EXACT [] +synonym: "2-deoxyribose 1-phosphate synthesis" EXACT [] +is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process +is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process + +[Term] +id: GO:0006017 +name: deoxyribose 1,5-bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT [] +synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT [] +synonym: "deoxyribose 1,5-bisphosphate formation" EXACT [] +synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT [] +is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process +is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process + +[Term] +id: GO:0006018 +name: deoxyribose 1-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribose 1-phosphate breakdown" EXACT [] +synonym: "deoxyribose 1-phosphate catabolism" EXACT [] +synonym: "deoxyribose 1-phosphate degradation" EXACT [] +is_a: GO:0046386 ! deoxyribose phosphate catabolic process +is_a: GO:0046388 ! deoxyribose 1-phosphate metabolic process + +[Term] +id: GO:0006019 +name: deoxyribose 5-phosphate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process +is_a: GO:0046835 ! carbohydrate phosphorylation + +[Term] +id: GO:0006020 +name: inositol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, ISBN:0198547684] +subset: gosubset_prok +synonym: "inositol metabolism" EXACT [] +synonym: "myo-inositol metabolic process" NARROW [] +synonym: "myo-inositol metabolism" NARROW [] +synonym: "vitamin Bh metabolic process" EXACT [] +synonym: "vitamin Bh metabolism" EXACT [] +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:0006021 +name: inositol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, ISBN:0198547684] +subset: gosubset_prok +synonym: "inositol anabolism" EXACT [] +synonym: "inositol biosynthesis" EXACT [] +synonym: "inositol formation" EXACT [] +synonym: "inositol synthesis" EXACT [] +synonym: "myo-inositol biosynthesis" NARROW [] +synonym: "myo-inositol biosynthetic process" NARROW [] +synonym: "vitamin Bh biosynthesis" EXACT [] +synonym: "vitamin Bh biosynthetic process" EXACT [] +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0046173 ! polyol biosynthetic process + +[Term] +id: GO:0006022 +name: aminoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminoglycan metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0006023 +name: aminoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminoglycan anabolism" EXACT [] +synonym: "aminoglycan biosynthesis" EXACT [] +synonym: "aminoglycan formation" EXACT [] +synonym: "aminoglycan synthesis" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0006024 +name: glycosaminoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +subset: gosubset_prok +synonym: "glycosaminoglycan anabolism" EXACT [] +synonym: "glycosaminoglycan biosynthesis" EXACT [] +synonym: "glycosaminoglycan formation" EXACT [] +synonym: "glycosaminoglycan synthesis" EXACT [] +is_a: GO:0006023 ! aminoglycan biosynthetic process +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0006025 +name: galactosaminoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] +subset: gosubset_prok +synonym: "galactosaminoglycan anabolism" EXACT [] +synonym: "galactosaminoglycan biosynthesis" EXACT [] +synonym: "galactosaminoglycan formation" EXACT [] +synonym: "galactosaminoglycan synthesis" EXACT [] +is_a: GO:0006023 ! aminoglycan biosynthetic process +is_a: GO:0046350 ! galactosaminoglycan metabolic process + +[Term] +id: GO:0006026 +name: aminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminoglycan breakdown" EXACT [] +synonym: "aminoglycan catabolism" EXACT [] +synonym: "aminoglycan degradation" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0006027 +name: glycosaminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +subset: gosubset_prok +synonym: "glycosaminoglycan breakdown" EXACT [] +synonym: "glycosaminoglycan catabolism" EXACT [] +synonym: "glycosaminoglycan degradation" EXACT [] +is_a: GO:0006026 ! aminoglycan catabolic process +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0006028 +name: galactosaminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] +subset: gosubset_prok +synonym: "galactosaminoglycan breakdown" EXACT [] +synonym: "galactosaminoglycan catabolism" EXACT [] +synonym: "galactosaminoglycan degradation" EXACT [] +is_a: GO:0006026 ! aminoglycan catabolic process +is_a: GO:0046350 ! galactosaminoglycan metabolic process + +[Term] +id: GO:0006029 +name: proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "proteoglycan metabolism" EXACT [] +synonym: "proteoglycan sulfate transfer" NARROW [] +is_a: GO:0044262 ! cellular carbohydrate metabolic process +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006030 +name: chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] +synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] +synonym: "chitin metabolism" EXACT [] +is_a: GO:0006044 ! N-acetylglucosamine metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0006031 +name: chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT [] +synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT [] +synonym: "chitin anabolism" EXACT [] +synonym: "chitin biosynthesis" EXACT [] +synonym: "chitin formation" EXACT [] +synonym: "chitin synthesis" EXACT [] +is_a: GO:0006030 ! chitin metabolic process +is_a: GO:0006045 ! N-acetylglucosamine biosynthetic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0006032 +name: chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT [] +synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT [] +synonym: "chitin breakdown" EXACT [] +synonym: "chitin catabolism" EXACT [] +synonym: "chitin degradation" EXACT [] +is_a: GO:0006030 ! chitin metabolic process +is_a: GO:0006046 ! N-acetylglucosamine catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0006033 +name: chitin localization +namespace: biological_process +def: "A process by which chitin is transported to, or maintained in, a specific location." [GOC:ai] +subset: gosubset_prok +synonym: "establishment and maintenance of chitin localization" EXACT [] +is_a: GO:0033037 ! polysaccharide localization + +[Term] +id: GO:0006034 +name: cuticle chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] +synonym: "cuticle chitin metabolism" EXACT [] +is_a: GO:0006030 ! chitin metabolic process + +[Term] +id: GO:0006035 +name: cuticle chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] +synonym: "cuticle chitin anabolism" EXACT [] +synonym: "cuticle chitin biosynthesis" EXACT [] +synonym: "cuticle chitin formation" EXACT [] +synonym: "cuticle chitin synthesis" EXACT [] +is_a: GO:0006031 ! chitin biosynthetic process +is_a: GO:0006034 ! cuticle chitin metabolic process +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0006036 +name: cuticle chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] +synonym: "cuticle chitin breakdown" EXACT [] +synonym: "cuticle chitin catabolism" EXACT [] +synonym: "cuticle chitin degradation" EXACT [] +is_a: GO:0006032 ! chitin catabolic process +is_a: GO:0006034 ! cuticle chitin metabolic process + +[Term] +id: GO:0006037 +name: cell wall chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] +subset: gosubset_prok +synonym: "cell wall chitin metabolism" EXACT [] +is_a: GO:0006030 ! chitin metabolic process +is_a: GO:0010383 ! cell wall polysaccharide metabolic process + +[Term] +id: GO:0006038 +name: cell wall chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] +synonym: "cell wall chitin anabolism" EXACT [] +synonym: "cell wall chitin biosynthesis" EXACT [] +synonym: "cell wall chitin formation" EXACT [] +synonym: "cell wall chitin synthesis" EXACT [] +is_a: GO:0006031 ! chitin biosynthetic process +is_a: GO:0006037 ! cell wall chitin metabolic process + +[Term] +id: GO:0006039 +name: cell wall chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] +subset: gosubset_prok +synonym: "cell wall chitin breakdown" EXACT [] +synonym: "cell wall chitin catabolism" EXACT [] +synonym: "cell wall chitin degradation" EXACT [] +is_a: GO:0006032 ! chitin catabolic process +is_a: GO:0006037 ! cell wall chitin metabolic process +is_a: GO:0016998 ! cell wall catabolic process + +[Term] +id: GO:0006040 +name: amino sugar metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "amino sugar metabolism" EXACT [] +synonym: "aminosaccharide metabolic process" EXACT [] +synonym: "aminosaccharide metabolism" EXACT [] +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0006041 +name: glucosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chitosamine metabolic process" EXACT [] +synonym: "chitosamine metabolism" EXACT [] +synonym: "glucosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process + +[Term] +id: GO:0006042 +name: glucosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chitosamine biosynthesis" EXACT [] +synonym: "chitosamine biosynthetic process" EXACT [] +synonym: "glucosamine anabolism" EXACT [] +synonym: "glucosamine biosynthesis" EXACT [] +synonym: "glucosamine formation" EXACT [] +synonym: "glucosamine synthesis" EXACT [] +is_a: GO:0006041 ! glucosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0006043 +name: glucosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chitosamine catabolic process" EXACT [] +synonym: "chitosamine catabolism" EXACT [] +synonym: "glucosamine breakdown" EXACT [] +synonym: "glucosamine catabolism" EXACT [] +synonym: "glucosamine degradation" EXACT [] +xref: MetaCyc:GLUAMCAT-PWY +is_a: GO:0006041 ! glucosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0006044 +name: N-acetylglucosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylglucosamine metabolism" EXACT [] +is_a: GO:0006041 ! glucosamine metabolic process + +[Term] +id: GO:0006045 +name: N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylglucosamine anabolism" EXACT [] +synonym: "N-acetylglucosamine biosynthesis" EXACT [] +synonym: "N-acetylglucosamine formation" EXACT [] +synonym: "N-acetylglucosamine synthesis" EXACT [] +is_a: GO:0006042 ! glucosamine biosynthetic process +is_a: GO:0006044 ! N-acetylglucosamine metabolic process + +[Term] +id: GO:0006046 +name: N-acetylglucosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylglucosamine breakdown" EXACT [] +synonym: "N-acetylglucosamine catabolism" EXACT [] +synonym: "N-acetylglucosamine degradation" EXACT [] +is_a: GO:0006043 ! glucosamine catabolic process +is_a: GO:0006044 ! N-acetylglucosamine metabolic process + +[Term] +id: GO:0006047 +name: UDP-N-acetylglucosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-N-acetylglucosamine metabolism" EXACT [] +is_a: GO:0006044 ! N-acetylglucosamine metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0006048 +name: UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-GlcNAc biosynthesis" EXACT [] +synonym: "UDP-GlcNAc biosynthetic process" EXACT [] +synonym: "UDP-N-acetylglucosamine anabolism" EXACT [] +synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT [] +synonym: "UDP-N-acetylglucosamine formation" EXACT [] +synonym: "UDP-N-acetylglucosamine synthesis" EXACT [] +xref: MetaCyc:UDPNAGSYN-PWY +is_a: GO:0006045 ! N-acetylglucosamine biosynthetic process +is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process + +[Term] +id: GO:0006049 +name: UDP-N-acetylglucosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-N-acetylglucosamine breakdown" EXACT [] +synonym: "UDP-N-acetylglucosamine catabolism" EXACT [] +synonym: "UDP-N-acetylglucosamine degradation" EXACT [] +is_a: GO:0006046 ! N-acetylglucosamine catabolic process +is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process + +[Term] +id: GO:0006050 +name: mannosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "mannosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process + +[Term] +id: GO:0006051 +name: N-acetylmannosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylmannosamine metabolism" EXACT [] +is_a: GO:0006050 ! mannosamine metabolic process + +[Term] +id: GO:0006052 +name: N-acetylmannosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylmannosamine anabolism" EXACT [] +synonym: "N-acetylmannosamine biosynthesis" EXACT [] +synonym: "N-acetylmannosamine formation" EXACT [] +synonym: "N-acetylmannosamine synthesis" EXACT [] +is_a: GO:0006051 ! N-acetylmannosamine metabolic process +is_a: GO:0046347 ! mannosamine biosynthetic process + +[Term] +id: GO:0006053 +name: N-acetylmannosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylmannosamine breakdown" EXACT [] +synonym: "N-acetylmannosamine catabolism" EXACT [] +synonym: "N-acetylmannosamine degradation" EXACT [] +is_a: GO:0006051 ! N-acetylmannosamine metabolic process +is_a: GO:0046346 ! mannosamine catabolic process + +[Term] +id: GO:0006054 +name: N-acetylneuraminate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylneuraminate metabolism" EXACT [] +synonym: "sialic acid metabolic process" BROAD [] +synonym: "sialic acid metabolism" BROAD [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006055 +name: CMP-N-acetylneuraminate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] +subset: gosubset_prok +synonym: "CMP-N-acetylneuraminate anabolism" EXACT [] +synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT [] +synonym: "CMP-N-acetylneuraminate formation" EXACT [] +synonym: "CMP-N-acetylneuraminate synthesis" EXACT [] +is_a: GO:0046380 ! N-acetylneuraminate biosynthetic process +is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process + +[Term] +id: GO:0006056 +name: mannoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannoprotein metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0006057 +name: mannoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannoprotein anabolism" EXACT [] +synonym: "mannoprotein biosynthesis" EXACT [] +synonym: "mannoprotein formation" EXACT [] +synonym: "mannoprotein synthesis" EXACT [] +is_a: GO:0006056 ! mannoprotein metabolic process +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0006058 +name: mannoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannoprotein breakdown" EXACT [] +synonym: "mannoprotein catabolism" EXACT [] +synonym: "mannoprotein degradation" EXACT [] +is_a: GO:0006056 ! mannoprotein metabolic process +is_a: GO:0006516 ! glycoprotein catabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0006059 +name: hexitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hexitol metabolism" EXACT [] +synonym: "sugar alcohol (hexitol) metabolic process" EXACT [] +synonym: "sugar alcohol (hexitol) metabolism" EXACT [] +is_a: GO:0019400 ! alditol metabolic process + +[Term] +id: GO:0006060 +name: sorbitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sorbitol metabolism" EXACT [] +xref: MetaCyc:P461-PWY +is_a: GO:0006059 ! hexitol metabolic process + +[Term] +id: GO:0006061 +name: sorbitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sorbitol anabolism" EXACT [] +synonym: "sorbitol biosynthesis" EXACT [] +synonym: "sorbitol formation" EXACT [] +synonym: "sorbitol synthesis" EXACT [] +is_a: GO:0006060 ! sorbitol metabolic process +is_a: GO:0019406 ! hexitol biosynthetic process + +[Term] +id: GO:0006062 +name: sorbitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sorbitol breakdown" EXACT [] +synonym: "sorbitol catabolism" EXACT [] +synonym: "sorbitol degradation" EXACT [] +xref: MetaCyc:SORBDEG-PWY +is_a: GO:0006060 ! sorbitol metabolic process +is_a: GO:0019407 ! hexitol catabolic process + +[Term] +id: GO:0006063 +name: uronic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "uronic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006064 +name: glucuronate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glucuronate breakdown" EXACT [] +synonym: "glucuronate catabolism" EXACT [] +synonym: "glucuronate degradation" EXACT [] +xref: MetaCyc:GURGAPCAT-PWY6 +is_a: GO:0019585 ! glucuronate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0006065 +name: UDP-glucuronate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-glucuronate anabolism" EXACT [] +synonym: "UDP-glucuronate biosynthesis" EXACT [] +synonym: "UDP-glucuronate formation" EXACT [] +synonym: "UDP-glucuronate synthesis" EXACT [] +xref: MetaCyc:PWY-4841 +xref: Reactome:173599 +xref: Reactome:211938 +xref: Reactome:221702 +xref: Reactome:230286 +xref: Reactome:238324 +xref: Reactome:244885 +xref: Reactome:249777 +xref: Reactome:252521 +xref: Reactome:255699 +xref: Reactome:259090 +xref: Reactome:262452 +xref: Reactome:265286 +xref: Reactome:268407 +xref: Reactome:274124 +xref: Reactome:280597 +xref: Reactome:282845 +xref: Reactome:286615 +xref: Reactome:289832 +xref: Reactome:290376 +xref: Reactome:291746 +xref: Reactome:292404 +xref: Reactome:293722 +is_a: GO:0046398 ! UDP-glucuronate metabolic process +is_a: GO:0046399 ! glucuronate biosynthetic process + +[Term] +id: GO:0006066 +name: cellular alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [ChEBI:30879, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "alcohol metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006067 +name: ethanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ethanol metabolism" EXACT [] +is_a: GO:0034308 ! monohydric alcohol metabolic process + +[Term] +id: GO:0006068 +name: ethanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ethanol breakdown" EXACT [] +synonym: "ethanol catabolism" EXACT [] +synonym: "ethanol degradation" EXACT [] +xref: MetaCyc:PWY0-341 +xref: Reactome:211963 +xref: Reactome:221728 +xref: Reactome:230310 +xref: Reactome:238348 +xref: Reactome:244906 +xref: Reactome:249799 +xref: Reactome:252539 +xref: Reactome:255717 +xref: Reactome:259110 +xref: Reactome:262469 +xref: Reactome:265316 +xref: Reactome:268428 +xref: Reactome:274145 +xref: Reactome:280618 +xref: Reactome:282875 +xref: Reactome:286633 +xref: Reactome:288339 +xref: Reactome:289840 +xref: Reactome:291761 +xref: Reactome:292422 +xref: Reactome:293736 +xref: Reactome:71384 +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0034310 ! monohydric alcohol catabolic process + +[Term] +id: GO:0006069 +name: ethanol oxidation +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006067 ! ethanol metabolic process + +[Term] +id: GO:0006070 +name: octanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators] +subset: gosubset_prok +synonym: "octanol metabolism" EXACT [] +is_a: GO:0034308 ! monohydric alcohol metabolic process + +[Term] +id: GO:0006071 +name: glycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerol metabolism" EXACT [] +xref: MetaCyc:GLYCEROLMETAB-PWY +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:0006072 +name: glycerol-3-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerol-3-phosphate metabolism" EXACT [] +is_a: GO:0006071 ! glycerol metabolic process + +[Term] +id: GO:0006073 +name: glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [ISBN:0198547684] +subset: gosubset_prok +synonym: "glucan metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0006074 +name: 1,3-beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "1,3-beta-glucan metabolism" EXACT [] +synonym: "beta-1,3 glucan metabolic process" EXACT [] +synonym: "beta-1,3 glucan metabolism" EXACT [] +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0006075 +name: 1,3-beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:ai] +synonym: "1,3-beta-glucan anabolism" EXACT [] +synonym: "1,3-beta-glucan biosynthesis" EXACT [] +synonym: "1,3-beta-glucan formation" EXACT [] +synonym: "1,3-beta-glucan synthesis" EXACT [] +synonym: "beta-1,3 glucan anabolism" EXACT [] +synonym: "beta-1,3 glucan biosynthesis" EXACT [] +synonym: "beta-1,3 glucan biosynthetic process" EXACT [] +synonym: "beta-1,3 glucan formation" EXACT [] +synonym: "beta-1,3 glucan synthesis" EXACT [] +is_a: GO:0006074 ! 1,3-beta-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0006076 +name: 1,3-beta-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-1,3 glucans." [GOC:ai] +subset: gosubset_prok +synonym: "1,3-beta-glucan breakdown" EXACT [] +synonym: "1,3-beta-glucan catabolism" EXACT [] +synonym: "1,3-beta-glucan degradation" EXACT [] +synonym: "beta-1,3 glucan breakdown" EXACT [] +synonym: "beta-1,3 glucan catabolic process" EXACT [] +synonym: "beta-1,3 glucan catabolism" EXACT [] +synonym: "beta-1,3 glucan degradation" EXACT [] +is_a: GO:0006074 ! 1,3-beta-glucan metabolic process +is_a: GO:0051275 ! beta-glucan catabolic process + +[Term] +id: GO:0006077 +name: 1,6-beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,6 glucans, compounds composed of glucose residues linked by 1,6-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "1,6-beta-glucan metabolism" EXACT [] +synonym: "beta-1,6 glucan metabolic process" EXACT [] +synonym: "beta-1,6 glucan metabolism" EXACT [] +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0006078 +name: 1,6-beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-1,6 glucans." [GOC:ai] +synonym: "1,6-beta-glucan anabolism" EXACT [] +synonym: "1,6-beta-glucan biosynthesis" EXACT [] +synonym: "1,6-beta-glucan formation" EXACT [] +synonym: "1,6-beta-glucan synthesis" EXACT [] +synonym: "beta-1,6 glucan anabolism" EXACT [] +synonym: "beta-1,6 glucan biosynthesis" EXACT [] +synonym: "beta-1,6 glucan biosynthetic process" EXACT [] +synonym: "beta-1,6 glucan formation" EXACT [] +synonym: "beta-1,6 glucan synthesis" EXACT [] +is_a: GO:0006077 ! 1,6-beta-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0006079 +name: 1,6-beta-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-1,6 glucans." [GOC:ai] +subset: gosubset_prok +synonym: "1,6-beta-glucan breakdown" EXACT [] +synonym: "1,6-beta-glucan catabolism" EXACT [] +synonym: "1,6-beta-glucan degradation" EXACT [] +synonym: "beta-1,6 glucan breakdown" EXACT [] +synonym: "beta-1,6 glucan catabolic process" EXACT [] +synonym: "beta-1,6 glucan catabolism" EXACT [] +synonym: "beta-1,6 glucan degradation" EXACT [] +is_a: GO:0006077 ! 1,6-beta-glucan metabolic process +is_a: GO:0051275 ! beta-glucan catabolic process + +[Term] +id: GO:0006080 +name: substituted mannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators] +subset: gosubset_prok +synonym: "substituted mannan metabolism" EXACT [] +is_a: GO:0010412 ! mannan metabolic process + +[Term] +id: GO:0006081 +name: cellular aldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "aldehyde metabolism" EXACT [] +synonym: "alkanal metabolic process" EXACT [] +synonym: "alkanal metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006082 +name: organic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "organic acid metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006083 +name: acetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "acetate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006084 +name: acetyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] +subset: gosubset_prok +synonym: "acetyl coenzyme A metabolic process" EXACT [] +synonym: "acetyl coenzyme A metabolism" EXACT [] +synonym: "acetyl-CoA metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0006085 +name: acetyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators] +subset: gosubset_prok +synonym: "acetyl-CoA anabolism" EXACT [] +synonym: "acetyl-CoA biosynthesis" EXACT [] +synonym: "acetyl-CoA formation" EXACT [] +synonym: "acetyl-CoA synthesis" EXACT [] +xref: MetaCyc:PWY-5173 +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process + +[Term] +id: GO:0006086 +name: acetyl-CoA biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +synonym: "acetyl-CoA anabolism from pyruvate" EXACT [] +synonym: "acetyl-CoA formation from pyruvate" EXACT [] +synonym: "acetyl-CoA synthesis from pyruvate" EXACT [] +synonym: "pyruvate dehydrogenase pathway" EXACT [] +xref: MetaCyc:PYRUVDEHYD-PWY +xref: Reactome:211577 +xref: Reactome:221353 +xref: Reactome:229992 +xref: Reactome:238011 +xref: Reactome:244626 +xref: Reactome:249565 +xref: Reactome:255528 +xref: Reactome:258900 +xref: Reactome:262277 +xref: Reactome:265130 +xref: Reactome:268253 +xref: Reactome:273936 +xref: Reactome:280415 +xref: Reactome:286432 +xref: Reactome:71397 +is_a: GO:0006085 ! acetyl-CoA biosynthetic process +is_a: GO:0006090 ! pyruvate metabolic process + +[Term] +id: GO:0006087 +name: pyruvate dehydrogenase bypass +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006090 ! pyruvate metabolic process + +[Term] +id: GO:0006088 +name: acetate to acetyl-CoA +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +consider: GO:0003987 + +[Term] +id: GO:0006089 +name: lactate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] +subset: gosubset_prok +synonym: "2-hydroxypropanoate metabolic process" EXACT [] +synonym: "2-hydroxypropanoate metabolism" EXACT [] +synonym: "alpha-hydroxypropionate metabolic process" EXACT [] +synonym: "alpha-hydroxypropionate metabolism" EXACT [] +synonym: "lactate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006090 +name: pyruvate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyruvate metabolism" EXACT [] +xref: MetaCyc:P41-PWY +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006091 +name: generation of precursor metabolites and energy +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "energy pathways" BROAD [] +synonym: "metabolic energy generation" RELATED [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006094 +name: gluconeogenesis +namespace: biological_process +def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "glucose biosynthesis" EXACT [] +synonym: "glucose biosynthetic process" EXACT [] +xref: MetaCyc:GLUCONEO-PWY +xref: Reactome:211959 +xref: Reactome:221724 +xref: Reactome:230306 +xref: Reactome:238346 +xref: Reactome:244904 +xref: Reactome:249797 +xref: Reactome:252537 +xref: Reactome:255715 +xref: Reactome:259108 +xref: Reactome:262467 +xref: Reactome:265302 +xref: Reactome:268426 +xref: Reactome:274143 +xref: Reactome:280616 +xref: Reactome:282853 +xref: Reactome:286631 +xref: Reactome:288321 +xref: Reactome:289853 +xref: Reactome:290391 +xref: Reactome:291759 +xref: Reactome:292413 +xref: Reactome:293734 +xref: Reactome:70263 +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0006096 +name: glycolysis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [ISBN:0716720094] +subset: gosubset_prok +xref: MetaCyc:PWY-1042 +xref: Reactome:205678 +xref: Reactome:211678 +xref: Reactome:215022 +xref: Reactome:221449 +xref: Reactome:224309 +xref: Reactome:230078 +xref: Reactome:232889 +xref: Reactome:238101 +xref: Reactome:241068 +xref: Reactome:244707 +xref: Reactome:246626 +xref: Reactome:249623 +xref: Reactome:250880 +xref: Reactome:252418 +xref: Reactome:253953 +xref: Reactome:255579 +xref: Reactome:256993 +xref: Reactome:258955 +xref: Reactome:260605 +xref: Reactome:262328 +xref: Reactome:263636 +xref: Reactome:265175 +xref: Reactome:266579 +xref: Reactome:268303 +xref: Reactome:271266 +xref: Reactome:273994 +xref: Reactome:277357 +xref: Reactome:280474 +xref: Reactome:281774 +xref: Reactome:282785 +xref: Reactome:284467 +xref: Reactome:286492 +xref: Reactome:288329 +xref: Reactome:289846 +xref: Reactome:290386 +xref: Reactome:290856 +xref: Reactome:291697 +xref: Reactome:292416 +xref: Reactome:292897 +xref: Reactome:293675 +xref: Reactome:70171 +xref: Reactome:70467 +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0006097 +name: glyoxylate cycle +namespace: biological_process +def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glyoxylate bypass" EXACT [] +xref: MetaCyc:GLYOXYLATE-BYPASS +is_a: GO:0044262 ! cellular carbohydrate metabolic process +is_a: GO:0046487 ! glyoxylate metabolic process + +[Term] +id: GO:0006098 +name: pentose-phosphate shunt +namespace: biological_process +def: "The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:PENTOSE-P-PWY] +subset: gosubset_prok +synonym: "hexose monophosphate pathway" EXACT [] +synonym: "pentose phosphate pathway" EXACT [] +synonym: "pentose phosphate shunt" EXACT [] +synonym: "pentose-phosphate pathway" EXACT [] +xref: MetaCyc:PENTOSE-P-PWY +xref: Reactome:211595 +xref: Reactome:221371 +xref: Reactome:230009 +xref: Reactome:238027 +xref: Reactome:244643 +xref: Reactome:249579 +xref: Reactome:252383 +xref: Reactome:255538 +xref: Reactome:258912 +xref: Reactome:262287 +xref: Reactome:265141 +xref: Reactome:268265 +xref: Reactome:273950 +xref: Reactome:280429 +xref: Reactome:282800 +xref: Reactome:286444 +xref: Reactome:288225 +xref: Reactome:289807 +xref: Reactome:290356 +xref: Reactome:291674 +xref: Reactome:292354 +xref: Reactome:293650 +xref: Reactome:71336 +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0006740 ! NADPH regeneration + +[Term] +id: GO:0006099 +name: tricarboxylic acid cycle +namespace: biological_process +def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "citric acid cycle" EXACT [] +synonym: "Krebs cycle" EXACT [] +synonym: "TCA cycle" EXACT [] +xref: MetaCyc:P102-PWY +xref: MetaCyc:P103-PWY +xref: MetaCyc:P104-PWY +xref: MetaCyc:P105-PWY +xref: MetaCyc:P42-PWY +xref: MetaCyc:P62-PWY +xref: MetaCyc:P63-PWY +xref: MetaCyc:P82-PWY +xref: MetaCyc:TCA +xref: Reactome:211545 +xref: Reactome:221322 +xref: Reactome:229962 +xref: Reactome:237979 +xref: Reactome:244598 +xref: Reactome:249541 +xref: Reactome:252352 +xref: Reactome:255507 +xref: Reactome:258879 +xref: Reactome:262256 +xref: Reactome:265143 +xref: Reactome:268230 +xref: Reactome:273912 +xref: Reactome:280391 +xref: Reactome:282813 +xref: Reactome:286448 +xref: Reactome:288227 +xref: Reactome:289779 +xref: Reactome:290340 +xref: Reactome:291646 +xref: Reactome:292355 +xref: Reactome:293654 +xref: Reactome:71403 +is_a: GO:0046356 ! acetyl-CoA catabolic process +relationship: part_of GO:0009060 ! aerobic respiration + +[Term] +id: GO:0006100 +name: tricarboxylic acid cycle intermediate metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai] +comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. +synonym: "citric acid cycle intermediate metabolic process" EXACT [] +synonym: "citric acid cycle intermediate metabolism" EXACT [] +synonym: "Krebs cycle intermediate metabolic process" EXACT [] +synonym: "Krebs cycle intermediate metabolism" EXACT [] +synonym: "TCA intermediate metabolic process" EXACT [] +synonym: "TCA intermediate metabolism" EXACT [] +synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT [] +is_obsolete: true +consider: GO:0006099 +consider: GO:0006101 +consider: GO:0006103 +consider: GO:0006104 +consider: GO:0006105 +consider: GO:0006106 +consider: GO:0006107 +consider: GO:0006108 + +[Term] +id: GO:0006101 +name: citrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "citrate metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006102 +name: isocitrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "isocitrate metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006103 +name: 2-oxoglutarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "2-ketoglutarate metabolic process" EXACT [] +synonym: "2-ketoglutarate metabolism" EXACT [] +synonym: "2-oxoglutarate metabolism" EXACT [] +synonym: "alpha-ketoglutarate metabolic process" EXACT [] +synonym: "alpha-ketoglutarate metabolism" EXACT [] +synonym: "alpha-oxoglutarate metabolic process" EXACT [] +synonym: "alpha-oxoglutarate metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006104 +name: succinyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the univalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai] +subset: gosubset_prok +synonym: "succinyl-CoA metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0006105 +name: succinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "succinate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006106 +name: fumarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fumarate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006107 +name: oxaloacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "oxaloacetate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006108 +name: malate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006109 +name: regulation of carbohydrate metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of carbohydrate metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0006110 +name: regulation of glycolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0006096 ! glycolysis + +[Term] +id: GO:0006111 +name: regulation of gluconeogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of glucose biosynthesis" BROAD [] +synonym: "regulation of glucose biosynthetic process" BROAD [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0006094 ! gluconeogenesis + +[Term] +id: GO:0006112 +name: energy reserve metabolic process +namespace: biological_process +subset: goslim_pir +subset: gosubset_prok +synonym: "energy reserve metabolism" EXACT [] +xref: Reactome:163685 +xref: Reactome:211615 +xref: Reactome:221389 +xref: Reactome:230333 +xref: Reactome:238041 +xref: Reactome:244657 +xref: Reactome:249589 +xref: Reactome:252553 +xref: Reactome:255545 +xref: Reactome:258920 +xref: Reactome:262294 +xref: Reactome:265146 +xref: Reactome:268270 +xref: Reactome:273956 +xref: Reactome:280435 +xref: Reactome:282866 +xref: Reactome:286452 +xref: Reactome:288345 +xref: Reactome:289856 +xref: Reactome:290394 +xref: Reactome:291775 +xref: Reactome:292426 +xref: Reactome:293756 +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + +[Term] +id: GO:0006113 +name: fermentation +namespace: biological_process +def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP)." [http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +subset: gosubset_prok +xref: MetaCyc:FERMENTATION-PWY +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + +[Term] +id: GO:0006114 +name: glycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerol anabolism" EXACT [] +synonym: "glycerol biosynthesis" EXACT [] +synonym: "glycerol formation" EXACT [] +synonym: "glycerol synthesis" EXACT [] +is_a: GO:0006071 ! glycerol metabolic process +is_a: GO:0046173 ! polyol biosynthetic process +relationship: part_of GO:0006113 ! fermentation + +[Term] +id: GO:0006115 +name: ethanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ethanol anabolism" EXACT [] +synonym: "ethanol biosynthesis" EXACT [] +synonym: "ethanol formation" EXACT [] +synonym: "ethanol synthesis" EXACT [] +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0034309 ! monohydric alcohol biosynthetic process + +[Term] +id: GO:0006116 +name: NADH oxidation +namespace: biological_process +def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] +subset: gosubset_prok +synonym: "NAD (reduced) dehydrogenation" EXACT [] +synonym: "NAD (reduced) oxidation" EXACT [] +synonym: "NADH dehydrogenation" EXACT [] +synonym: "reduced NAD dehydrogenation" EXACT [] +synonym: "reduced NAD oxidation" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] +is_a: GO:0006734 ! NADH metabolic process +is_a: GO:0019674 ! NAD metabolic process + +[Term] +id: GO:0006117 +name: acetaldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "acetaldehyde metabolism" EXACT [] +synonym: "ethanal metabolic process" EXACT [] +synonym: "ethanal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:0006118 +name: electron transport +namespace: biological_process +def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [http://cancerweb.ncl.ac.uk/] +comment: This term was obsoleted because it describes a molecular function. +synonym: "6-phosphofructokinase reduction" RELATED [] +synonym: "dihydrobiopterin reduction" RELATED [] +synonym: "dihydrolipoamide reduction" RELATED [] +synonym: "dihydrolipoylprotein reduction" RELATED [] +synonym: "dihydropteridine reduction" RELATED [] +synonym: "electron transfer" EXACT [] +synonym: "other pathways of electron transport" RELATED [] +synonym: "oxidized glutathione reduction" RELATED [] +synonym: "protein-disulfide reduction" RELATED [] +is_obsolete: true +replaced_by: GO:0055114 +consider: GO:0016491 +consider: GO:0022904 + +[Term] +id: GO:0006119 +name: oxidative phosphorylation +namespace: biological_process +def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471331309 "Biochemical Pathways"] +subset: goslim_pir +subset: gosubset_prok +synonym: "respiratory-chain phosphorylation" EXACT [] +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0006120 +name: mitochondrial electron transport, NADH to ubiquinone +namespace: biological_process +def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] +synonym: "complex I (NADH to ubiquinone)" RELATED [] +synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] +xref: Reactome:163217 +xref: Reactome:209721 +xref: Reactome:219484 +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006121 +name: mitochondrial electron transport, succinate to ubiquinone +namespace: biological_process +def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] +synonym: "complex II (succinate to ubiquinone)" RELATED [] +synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] +synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] +xref: Reactome:163213 +xref: Reactome:165642 +xref: Reactome:211276 +xref: Reactome:221095 +xref: Reactome:237760 +xref: Reactome:244428 +xref: Reactome:249392 +xref: Reactome:252261 +xref: Reactome:255413 +xref: Reactome:258765 +xref: Reactome:262169 +xref: Reactome:264987 +xref: Reactome:268119 +xref: Reactome:273768 +xref: Reactome:286293 +xref: Reactome:291579 +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006122 +name: mitochondrial electron transport, ubiquinol to cytochrome c +namespace: biological_process +def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] +synonym: "complex III (ubiquinone to cytochrome c)" RELATED [] +xref: Reactome:164651 +xref: Reactome:207804 +xref: Reactome:217332 +xref: Reactome:234706 +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006123 +name: mitochondrial electron transport, cytochrome c to oxygen +namespace: biological_process +def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] +synonym: "complex IV (reduction of O2)" RELATED [] +xref: Reactome:163214 +xref: Reactome:207777 +xref: Reactome:217302 +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006124 +name: ferredoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ferredoxin metabolism" EXACT [] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006125 +name: thioredoxin pathway +namespace: biological_process +def: "OBSOLETE." [GOC:mtg_electron_transport] +comment: This term was made obsolete because it is not clear what it is intended to represent. +synonym: "thioredoxin reduction" NARROW [] +xref: MetaCyc:THIOREDOX-PWY +is_obsolete: true +consider: GO:0045454 + +[Term] +id: GO:0006126 +name: other pathways of electron transport +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +replaced_by: GO:0022900 + +[Term] +id: GO:0006127 +name: glycerophosphate shuttle +namespace: biological_process +def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006839 ! mitochondrial transport +relationship: part_of GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0006128 +name: oxidized glutathione reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway. +is_obsolete: true +consider: GO:0004362 +consider: GO:0006749 +consider: GO:0022900 + +[Term] +id: GO:0006129 +name: protein-disulfide reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "protein-disulphide reduction" EXACT [] +is_obsolete: true +consider: GO:0019153 +consider: GO:0022900 + +[Term] +id: GO:0006130 +name: 6-phosphofructokinase reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. +is_obsolete: true +consider: GO:0003872 +consider: GO:0022900 + +[Term] +id: GO:0006131 +name: dihydrolipoamide reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0004148 +consider: GO:0022900 +consider: GO:0051068 + +[Term] +id: GO:0006132 +name: dihydrolipoylprotein reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0004148 +consider: GO:0022900 + +[Term] +id: GO:0006133 +name: 5,10-methylenetetrahydrofolate oxidation +namespace: biological_process +def: "OBSOLETE." [GOC:mtg_electron_transport] +comment: This term was made obsolete because it is defined as a function term and is in the process ontology. +is_obsolete: true +consider: GO:0004487 +consider: GO:0004488 +consider: GO:0004489 +consider: GO:0033738 + +[Term] +id: GO:0006134 +name: dihydrobiopterin reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0022900 +consider: GO:0047040 +consider: GO:0051066 + +[Term] +id: GO:0006135 +name: dihydropteridine reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0004155 +consider: GO:0022900 +consider: GO:0051067 + +[Term] +id: GO:0006139 +name: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044238 ! primary metabolic process + +[Term] +id: GO:0006140 +name: regulation of nucleotide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of nucleotide metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: regulates GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0006141 +name: regulation of purine base metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of purine base metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: regulates GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0006142 +name: regulation of pyrimidine base metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidines." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of pyrimidine base metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: regulates GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0006143 +name: purine metabolic process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more appropriate terms were created. +is_obsolete: true +consider: GO:0006144 +consider: GO:0006163 +consider: GO:0042278 + +[Term] +id: GO:0006144 +name: purine base metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] +subset: gosubset_prok +synonym: "purine base metabolism" EXACT [] +synonym: "purine metabolic process" NARROW [] +synonym: "purine metabolism" NARROW [] +is_a: GO:0009112 ! nucleobase metabolic process + +[Term] +id: GO:0006145 +name: purine base catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] +subset: gosubset_prok +synonym: "purine base breakdown" EXACT [] +synonym: "purine base catabolism" EXACT [] +synonym: "purine base degradation" EXACT [] +is_a: GO:0006144 ! purine base metabolic process +is_a: GO:0046113 ! nucleobase catabolic process + +[Term] +id: GO:0006146 +name: adenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "adenine breakdown" EXACT [] +synonym: "adenine catabolism" EXACT [] +synonym: "adenine degradation" EXACT [] +is_a: GO:0006145 ! purine base catabolic process +is_a: GO:0046083 ! adenine metabolic process + +[Term] +id: GO:0006147 +name: guanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] +subset: gosubset_prok +synonym: "guanine breakdown" EXACT [] +synonym: "guanine catabolism" EXACT [] +synonym: "guanine degradation" EXACT [] +is_a: GO:0006145 ! purine base catabolic process +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0006148 +name: inosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] +subset: gosubset_prok +synonym: "inosine breakdown" EXACT [] +synonym: "inosine catabolism" EXACT [] +synonym: "inosine degradation" EXACT [] +is_a: GO:0046102 ! inosine metabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process + +[Term] +id: GO:0006149 +name: deoxyinosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyinosine breakdown" EXACT [] +synonym: "deoxyinosine catabolism" EXACT [] +synonym: "deoxyinosine degradation" EXACT [] +is_a: GO:0046094 ! deoxyinosine metabolic process +is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006150 +name: hypoxanthine oxidation +namespace: biological_process +subset: gosubset_prok +is_a: GO:0009114 ! hypoxanthine catabolic process + +[Term] +id: GO:0006151 +name: xanthine oxidation +namespace: biological_process +def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009115 ! xanthine catabolic process + +[Term] +id: GO:0006152 +name: purine nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] +subset: gosubset_prok +synonym: "purine nucleoside breakdown" EXACT [] +synonym: "purine nucleoside catabolism" EXACT [] +synonym: "purine nucleoside degradation" EXACT [] +is_a: GO:0009164 ! nucleoside catabolic process +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0006153 +name: purine nucleosidase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0008477 + +[Term] +id: GO:0006154 +name: adenosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] +subset: gosubset_prok +synonym: "adenosine breakdown" EXACT [] +synonym: "adenosine catabolism" EXACT [] +synonym: "adenosine degradation" EXACT [] +is_a: GO:0046085 ! adenosine metabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process + +[Term] +id: GO:0006155 +name: adenosine deaminase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0004000 + +[Term] +id: GO:0006156 +name: adenosine phosphorolysis +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006154 ! adenosine catabolic process + +[Term] +id: GO:0006157 +name: deoxyadenosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyadenosine breakdown" EXACT [] +synonym: "deoxyadenosine catabolism" EXACT [] +synonym: "deoxyadenosine degradation" EXACT [] +is_a: GO:0046090 ! deoxyadenosine metabolic process +is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006158 +name: deoxyadenosine deaminase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0046936 + +[Term] +id: GO:0006159 +name: deoxyadenosine phosphorolysis +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006157 ! deoxyadenosine catabolic process + +[Term] +id: GO:0006160 +name: guanosine phosphorolysis +namespace: biological_process +subset: gosubset_prok +is_a: GO:0008617 ! guanosine metabolic process + +[Term] +id: GO:0006161 +name: deoxyguanosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "deoxyguanosine breakdown" EXACT [] +synonym: "deoxyguanosine catabolism" EXACT [] +synonym: "deoxyguanosine degradation" EXACT [] +is_a: GO:0042453 ! deoxyguanosine metabolic process +is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006162 +name: purine/pyrimidine nucleoside diphosphate reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0004748 + +[Term] +id: GO:0006163 +name: purine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine metabolic process" NARROW [] +synonym: "purine metabolism" NARROW [] +synonym: "purine nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0006164 +name: purine nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleotide anabolism" EXACT [] +synonym: "purine nucleotide biosynthesis" EXACT [] +synonym: "purine nucleotide formation" EXACT [] +synonym: "purine nucleotide synthesis" EXACT [] +xref: MetaCyc:DENOVOPURINE2-PWY +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0006165 +name: nucleoside diphosphate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:0046939 ! nucleotide phosphorylation + +[Term] +id: GO:0006166 +name: purine ribonucleoside salvage +namespace: biological_process +def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +xref: MetaCyc:P121-PWY +is_a: GO:0043101 ! purine salvage +is_a: GO:0043174 ! nucleoside salvage +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0006167 +name: AMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "AMP anabolism" EXACT [] +synonym: "AMP biosynthesis" EXACT [] +synonym: "AMP formation" EXACT [] +synonym: "AMP synthesis" EXACT [] +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046033 ! AMP metabolic process + +[Term] +id: GO:0006168 +name: adenine salvage +namespace: biological_process +def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "adenine salvage pathway" EXACT [] +synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] +is_a: GO:0043096 ! purine base salvage +is_a: GO:0046083 ! adenine metabolic process + +[Term] +id: GO:0006169 +name: adenosine salvage +namespace: biological_process +def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] +is_a: GO:0006166 ! purine ribonucleoside salvage +is_a: GO:0046085 ! adenosine metabolic process + +[Term] +id: GO:0006170 +name: dAMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dAMP anabolism" EXACT [] +synonym: "dAMP biosynthesis" EXACT [] +synonym: "dAMP formation" EXACT [] +synonym: "dAMP synthesis" EXACT [] +is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046053 ! dAMP metabolic process + +[Term] +id: GO:0006171 +name: cAMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3',5' cAMP biosynthesis" EXACT [] +synonym: "3',5' cAMP biosynthetic process" EXACT [] +synonym: "3',5'-cAMP biosynthesis" EXACT [] +synonym: "3',5'-cAMP biosynthetic process" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "cAMP anabolism" EXACT [] +synonym: "cAMP biosynthesis" EXACT [] +synonym: "cAMP formation" EXACT [] +synonym: "cAMP synthesis" EXACT [] +synonym: "cyclic AMP biosynthesis" EXACT [] +synonym: "cyclic AMP biosynthetic process" EXACT [] +is_a: GO:0009190 ! cyclic nucleotide biosynthetic process +is_a: GO:0046058 ! cAMP metabolic process + +[Term] +id: GO:0006172 +name: ADP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "ADP anabolism" EXACT [] +synonym: "ADP biosynthesis" EXACT [] +synonym: "ADP formation" EXACT [] +synonym: "ADP synthesis" EXACT [] +is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0006173 +name: dADP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dADP anabolism" EXACT [] +synonym: "dADP biosynthesis" EXACT [] +synonym: "dADP formation" EXACT [] +synonym: "dADP synthesis" EXACT [] +is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046056 ! dADP metabolic process + +[Term] +id: GO:0006174 +name: dADP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046056 ! dADP metabolic process + +[Term] +id: GO:0006175 +name: dATP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dATP anabolism" EXACT [] +synonym: "dATP biosynthesis" EXACT [] +synonym: "dATP formation" EXACT [] +synonym: "dATP synthesis" EXACT [] +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046060 ! dATP metabolic process + +[Term] +id: GO:0006176 +name: dATP biosynthetic process from ADP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dATP anabolism from ADP" EXACT [] +synonym: "dATP formation from ADP" EXACT [] +synonym: "dATP synthesis from ADP" EXACT [] +is_a: GO:0006175 ! dATP biosynthetic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0006177 +name: GMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GMP anabolism" EXACT [] +synonym: "GMP biosynthesis" EXACT [] +synonym: "GMP formation" EXACT [] +synonym: "GMP synthesis" EXACT [] +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046037 ! GMP metabolic process + +[Term] +id: GO:0006178 +name: guanine salvage +namespace: biological_process +def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] +is_a: GO:0043096 ! purine base salvage +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0006179 +name: guanosine salvage +namespace: biological_process +def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] +is_a: GO:0006166 ! purine ribonucleoside salvage +is_a: GO:0008617 ! guanosine metabolic process + +[Term] +id: GO:0006180 +name: deoxyguanosine salvage +namespace: biological_process +def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043098 ! purine deoxyribonucleoside salvage + +[Term] +id: GO:0006181 +name: dGMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dGMP anabolism" EXACT [] +synonym: "dGMP biosynthesis" EXACT [] +synonym: "dGMP formation" EXACT [] +synonym: "dGMP synthesis" EXACT [] +is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046054 ! dGMP metabolic process + +[Term] +id: GO:0006182 +name: cGMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cGMP anabolism" EXACT [] +synonym: "cGMP biosynthesis" EXACT [] +synonym: "cGMP formation" EXACT [] +synonym: "cGMP synthesis" EXACT [] +is_a: GO:0009190 ! cyclic nucleotide biosynthetic process +is_a: GO:0046068 ! cGMP metabolic process + +[Term] +id: GO:0006183 +name: GTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GTP anabolism" EXACT [] +synonym: "GTP biosynthesis" EXACT [] +synonym: "GTP formation" EXACT [] +synonym: "GTP synthesis" EXACT [] +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046039 ! GTP metabolic process + +[Term] +id: GO:0006184 +name: GTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GTP breakdown" EXACT [] +synonym: "GTP catabolism" EXACT [] +synonym: "GTP degradation" EXACT [] +synonym: "GTP hydrolysis" EXACT [] +is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process +is_a: GO:0046039 ! GTP metabolic process + +[Term] +id: GO:0006185 +name: dGDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dGDP anabolism" EXACT [] +synonym: "dGDP biosynthesis" EXACT [] +synonym: "dGDP formation" EXACT [] +synonym: "dGDP synthesis" EXACT [] +is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046066 ! dGDP metabolic process + +[Term] +id: GO:0006186 +name: dGDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046066 ! dGDP metabolic process + +[Term] +id: GO:0006187 +name: dGTP biosynthetic process from dGDP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dGTP anabolism from dGDP" EXACT [] +synonym: "dGTP formation from dGDP" EXACT [] +synonym: "dGTP synthesis from dGDP" EXACT [] +is_a: GO:0046066 ! dGDP metabolic process +is_a: GO:0046071 ! dGTP biosynthetic process + +[Term] +id: GO:0006188 +name: IMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "IMP anabolism" EXACT [] +synonym: "IMP biosynthesis" EXACT [] +synonym: "IMP formation" EXACT [] +synonym: "IMP synthesis" EXACT [] +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046040 ! IMP metabolic process + +[Term] +id: GO:0006189 +name: 'de novo' IMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] +subset: gosubset_prok +synonym: "'de novo' IMP anabolism" EXACT [] +synonym: "'de novo' IMP biosynthesis" EXACT [] +synonym: "'de novo' IMP formation" EXACT [] +synonym: "'de novo' IMP synthesis" EXACT [] +synonym: "'de novo' purine biosynthesis" BROAD [] +synonym: "'de novo' purine biosynthetic process" BROAD [] +is_a: GO:0006188 ! IMP biosynthetic process + +[Term] +id: GO:0006190 +name: inosine salvage +namespace: biological_process +def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED [] +synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] +is_a: GO:0006166 ! purine ribonucleoside salvage +is_a: GO:0046102 ! inosine metabolic process + +[Term] +id: GO:0006191 +name: deoxyinosine salvage +namespace: biological_process +def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043098 ! purine deoxyribonucleoside salvage + +[Term] +id: GO:0006192 +name: IDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046707 ! IDP metabolic process + +[Term] +id: GO:0006193 +name: ITP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ITP breakdown" EXACT [] +synonym: "ITP catabolism" EXACT [] +synonym: "ITP degradation" EXACT [] +synonym: "ITP hydrolysis" EXACT [] +is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process +is_a: GO:0046041 ! ITP metabolic process + +[Term] +id: GO:0006194 +name: dIDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process + +[Term] +id: GO:0006195 +name: purine nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleotide breakdown" EXACT [] +synonym: "purine nucleotide catabolism" EXACT [] +synonym: "purine nucleotide degradation" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0006196 +name: AMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "AMP breakdown" EXACT [] +synonym: "AMP catabolism" EXACT [] +synonym: "AMP degradation" EXACT [] +is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process +is_a: GO:0046033 ! AMP metabolic process + +[Term] +id: GO:0006197 +name: adenylate deaminase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0003876 + +[Term] +id: GO:0006198 +name: cAMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3',5' cAMP catabolic process" EXACT [] +synonym: "3',5' cAMP catabolism" EXACT [] +synonym: "3',5'-cAMP catabolic process" EXACT [] +synonym: "3',5'-cAMP catabolism" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "cAMP breakdown" EXACT [] +synonym: "cAMP catabolism" EXACT [] +synonym: "cAMP degradation" EXACT [] +synonym: "cyclic AMP catabolic process" EXACT [] +synonym: "cyclic AMP catabolism" EXACT [] +is_a: GO:0009214 ! cyclic nucleotide catabolic process +is_a: GO:0046058 ! cAMP metabolic process + +[Term] +id: GO:0006199 +name: ADP reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0051061 + +[Term] +id: GO:0006200 +name: ATP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] +subset: gosubset_prok +synonym: "ATP breakdown" EXACT [] +synonym: "ATP catabolism" EXACT [] +synonym: "ATP degradation" EXACT [] +synonym: "ATP hydrolysis" EXACT [] +is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process +is_a: GO:0046034 ! ATP metabolic process + +[Term] +id: GO:0006201 +name: GMP catabolic process to IMP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GMP breakdown to IMP" EXACT [] +synonym: "GMP degradation to IMP" EXACT [] +is_a: GO:0046038 ! GMP catabolic process +is_a: GO:0046040 ! IMP metabolic process + +[Term] +id: GO:0006202 +name: GMP catabolic process to guanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GMP breakdown to guanine" EXACT [] +synonym: "GMP degradation to guanine" EXACT [] +is_a: GO:0046038 ! GMP catabolic process +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0006203 +name: dGTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dGTP breakdown" EXACT [] +synonym: "dGTP catabolism" EXACT [] +synonym: "dGTP degradation" EXACT [] +is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046070 ! dGTP metabolic process + +[Term] +id: GO:0006204 +name: IMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "IMP breakdown" EXACT [] +synonym: "IMP catabolism" EXACT [] +synonym: "IMP degradation" EXACT [] +is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process +is_a: GO:0046040 ! IMP metabolic process + +[Term] +id: GO:0006205 +name: pyrimidine metabolic process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more appropriate terms were created. +is_obsolete: true +consider: GO:0006206 +consider: GO:0006213 +consider: GO:0006220 + +[Term] +id: GO:0006206 +name: pyrimidine base metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyrimidine base metabolism" EXACT [] +synonym: "pyrimidine metabolic process" BROAD [] +synonym: "pyrimidine metabolism" BROAD [] +is_a: GO:0009112 ! nucleobase metabolic process + +[Term] +id: GO:0006207 +name: 'de novo' pyrimidine base biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] +subset: gosubset_prok +synonym: "'de novo' pyrimidine base anabolism" EXACT [] +synonym: "'de novo' pyrimidine base biosynthesis" EXACT [] +synonym: "'de novo' pyrimidine base formation" EXACT [] +synonym: "'de novo' pyrimidine base synthesis" EXACT [] +xref: MetaCyc:PYRIMSYN-PWY +is_a: GO:0019856 ! pyrimidine base biosynthetic process + +[Term] +id: GO:0006208 +name: pyrimidine base catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyrimidine base breakdown" EXACT [] +synonym: "pyrimidine base catabolism" EXACT [] +synonym: "pyrimidine base degradation" EXACT [] +is_a: GO:0006206 ! pyrimidine base metabolic process +is_a: GO:0046113 ! nucleobase catabolic process + +[Term] +id: GO:0006209 +name: cytosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] +subset: gosubset_prok +synonym: "cytosine breakdown" EXACT [] +synonym: "cytosine catabolism" EXACT [] +synonym: "cytosine degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine base catabolic process +is_a: GO:0019858 ! cytosine metabolic process + +[Term] +id: GO:0006210 +name: thymine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] +subset: gosubset_prok +synonym: "thymine breakdown" EXACT [] +synonym: "thymine catabolism" EXACT [] +synonym: "thymine degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine base catabolic process +is_a: GO:0019859 ! thymine metabolic process + +[Term] +id: GO:0006211 +name: 5-methylcytosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "5-methylcytosine breakdown" EXACT [] +synonym: "5-methylcytosine catabolism" EXACT [] +synonym: "5-methylcytosine degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine base catabolic process +is_a: GO:0019857 ! 5-methylcytosine metabolic process + +[Term] +id: GO:0006212 +name: uracil catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "uracil breakdown" EXACT [] +synonym: "uracil catabolism" EXACT [] +synonym: "uracil degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine base catabolic process +is_a: GO:0019860 ! uracil metabolic process + +[Term] +id: GO:0006213 +name: pyrimidine nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +subset: gosubset_prok +synonym: "pyrimidine metabolic process" BROAD [] +synonym: "pyrimidine metabolism" BROAD [] +synonym: "pyrimidine nucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0006214 +name: thymidine catabolic process +namespace: biological_process +alt_id: GO:0006215 +def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyribosylthymine catabolic process" EXACT [] +synonym: "deoxyribosylthymine catabolism" EXACT [] +synonym: "thymidine breakdown" EXACT [] +synonym: "thymidine catabolism" EXACT [] +synonym: "thymidine degradation" EXACT [] +is_a: GO:0046104 ! thymidine metabolic process +is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006216 +name: cytidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai] +subset: gosubset_prok +synonym: "cytidine breakdown" EXACT [] +synonym: "cytidine catabolism" EXACT [] +synonym: "cytidine degradation" EXACT [] +is_a: GO:0046087 ! cytidine metabolic process +is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process + +[Term] +id: GO:0006217 +name: deoxycytidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxycytidine breakdown" EXACT [] +synonym: "deoxycytidine catabolism" EXACT [] +synonym: "deoxycytidine degradation" EXACT [] +is_a: GO:0046092 ! deoxycytidine metabolic process +is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006218 +name: uridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "uridine breakdown" EXACT [] +synonym: "uridine catabolism" EXACT [] +synonym: "uridine degradation" EXACT [] +is_a: GO:0046108 ! uridine metabolic process +is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process + +[Term] +id: GO:0006219 +name: deoxyuridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyuridine breakdown" EXACT [] +synonym: "deoxyuridine catabolism" EXACT [] +synonym: "deoxyuridine degradation" EXACT [] +is_a: GO:0046096 ! deoxyuridine metabolic process +is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006220 +name: pyrimidine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine metabolic process" BROAD [] +synonym: "pyrimidine metabolism" BROAD [] +synonym: "pyrimidine nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0006221 +name: pyrimidine nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleotide anabolism" EXACT [] +synonym: "pyrimidine nucleotide biosynthesis" EXACT [] +synonym: "pyrimidine nucleotide formation" EXACT [] +synonym: "pyrimidine nucleotide synthesis" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0006222 +name: UMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "UMP anabolism" EXACT [] +synonym: "UMP biosynthesis" EXACT [] +synonym: "UMP formation" EXACT [] +synonym: "UMP synthesis" EXACT [] +is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046049 ! UMP metabolic process + +[Term] +id: GO:0006223 +name: uracil salvage +namespace: biological_process +def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0019860 ! uracil metabolic process +is_a: GO:0043100 ! pyrimidine base salvage + +[Term] +id: GO:0006224 +name: uridine kinase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0004849 + +[Term] +id: GO:0006225 +name: UDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "UDP anabolism" EXACT [] +synonym: "UDP biosynthesis" EXACT [] +synonym: "UDP formation" EXACT [] +synonym: "UDP synthesis" EXACT [] +is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046048 ! UDP metabolic process + +[Term] +id: GO:0006226 +name: dUMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dUMP anabolism" EXACT [] +synonym: "dUMP biosynthesis" EXACT [] +synonym: "dUMP formation" EXACT [] +synonym: "dUMP synthesis" EXACT [] +is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046078 ! dUMP metabolic process + +[Term] +id: GO:0006227 +name: dUDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dUDP anabolism" EXACT [] +synonym: "dUDP biosynthesis" EXACT [] +synonym: "dUDP formation" EXACT [] +synonym: "dUDP synthesis" EXACT [] +is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046077 ! dUDP metabolic process + +[Term] +id: GO:0006228 +name: UTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "UTP anabolism" EXACT [] +synonym: "UTP biosynthesis" EXACT [] +synonym: "UTP formation" EXACT [] +synonym: "UTP synthesis" EXACT [] +is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046051 ! UTP metabolic process + +[Term] +id: GO:0006229 +name: dUTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dUTP anabolism" EXACT [] +synonym: "dUTP biosynthesis" EXACT [] +synonym: "dUTP formation" EXACT [] +synonym: "dUTP synthesis" EXACT [] +is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046080 ! dUTP metabolic process + +[Term] +id: GO:0006230 +name: TMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "TMP anabolism" EXACT [] +synonym: "TMP biosynthesis" EXACT [] +synonym: "TMP formation" EXACT [] +synonym: "TMP synthesis" EXACT [] +is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046044 ! TMP metabolic process + +[Term] +id: GO:0006231 +name: dTMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dTMP anabolism" EXACT [] +synonym: "dTMP biosynthesis" EXACT [] +synonym: "dTMP formation" EXACT [] +synonym: "dTMP synthesis" EXACT [] +is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046073 ! dTMP metabolic process + +[Term] +id: GO:0006232 +name: TDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "TDP anabolism" EXACT [] +synonym: "TDP biosynthesis" EXACT [] +synonym: "TDP formation" EXACT [] +synonym: "TDP synthesis" EXACT [] +is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046043 ! TDP metabolic process + +[Term] +id: GO:0006233 +name: dTDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dTDP anabolism" EXACT [] +synonym: "dTDP biosynthesis" EXACT [] +synonym: "dTDP formation" EXACT [] +synonym: "dTDP synthesis" EXACT [] +is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046072 ! dTDP metabolic process + +[Term] +id: GO:0006234 +name: TTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "TTP anabolism" EXACT [] +synonym: "TTP biosynthesis" EXACT [] +synonym: "TTP formation" EXACT [] +synonym: "TTP synthesis" EXACT [] +is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046046 ! TTP metabolic process + +[Term] +id: GO:0006235 +name: dTTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dTTP anabolism" EXACT [] +synonym: "dTTP biosynthesis" EXACT [] +synonym: "dTTP formation" EXACT [] +synonym: "dTTP synthesis" EXACT [] +is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046075 ! dTTP metabolic process + +[Term] +id: GO:0006236 +name: cytidine salvage +namespace: biological_process +def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043097 ! pyrimidine nucleoside salvage +is_a: GO:0046087 ! cytidine metabolic process + +[Term] +id: GO:0006237 +name: deoxycytidine salvage +namespace: biological_process +def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage +is_a: GO:0046092 ! deoxycytidine metabolic process + +[Term] +id: GO:0006238 +name: CMP salvage +namespace: biological_process +def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "cytidine monophosphate salvage" EXACT [] +is_a: GO:0010138 ! pyrimidine ribonucleotide salvage +is_a: GO:0046035 ! CMP metabolic process + +[Term] +id: GO:0006239 +name: dCMP salvage +namespace: biological_process +def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "deoxycytidine monophosphate salvage" EXACT [] +is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage +is_a: GO:0046063 ! dCMP metabolic process + +[Term] +id: GO:0006240 +name: dCDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dCDP anabolism" EXACT [] +synonym: "dCDP biosynthesis" EXACT [] +synonym: "dCDP formation" EXACT [] +synonym: "dCDP synthesis" EXACT [] +is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046062 ! dCDP metabolic process + +[Term] +id: GO:0006241 +name: CTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "CTP anabolism" EXACT [] +synonym: "CTP biosynthesis" EXACT [] +synonym: "CTP formation" EXACT [] +synonym: "CTP synthesis" EXACT [] +is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046036 ! CTP metabolic process + +[Term] +id: GO:0006242 +name: dCTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dCTP anabolism" EXACT [] +synonym: "dCTP biosynthesis" EXACT [] +synonym: "dCTP formation" EXACT [] +synonym: "dCTP synthesis" EXACT [] +is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046065 ! dCTP metabolic process + +[Term] +id: GO:0006243 +name: CTP deamination +namespace: biological_process +subset: gosubset_prok +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0046036 ! CTP metabolic process + +[Term] +id: GO:0006244 +name: pyrimidine nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleotide breakdown" EXACT [] +synonym: "pyrimidine nucleotide catabolism" EXACT [] +synonym: "pyrimidine nucleotide degradation" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0006245 +name: TDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "TDP breakdown" EXACT [] +synonym: "TDP catabolism" EXACT [] +synonym: "TDP degradation" EXACT [] +is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process +is_a: GO:0046043 ! TDP metabolic process + +[Term] +id: GO:0006246 +name: dTDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dTDP breakdown" EXACT [] +synonym: "dTDP catabolism" EXACT [] +synonym: "dTDP degradation" EXACT [] +is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046072 ! dTDP metabolic process + +[Term] +id: GO:0006247 +name: TTP reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0051064 + +[Term] +id: GO:0006248 +name: CMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "CMP breakdown" EXACT [] +synonym: "CMP catabolism" EXACT [] +synonym: "CMP degradation" EXACT [] +is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process +is_a: GO:0046035 ! CMP metabolic process + +[Term] +id: GO:0006249 +name: dCMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dCMP breakdown" EXACT [] +synonym: "dCMP catabolism" EXACT [] +synonym: "dCMP degradation" EXACT [] +is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046063 ! dCMP metabolic process + +[Term] +id: GO:0006250 +name: CDP reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0051063 + +[Term] +id: GO:0006251 +name: dCDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dCDP breakdown" EXACT [] +synonym: "dCDP catabolism" EXACT [] +synonym: "dCDP degradation" EXACT [] +is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046062 ! dCDP metabolic process + +[Term] +id: GO:0006252 +name: CTP reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0051065 + +[Term] +id: GO:0006253 +name: dCTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dCTP breakdown" EXACT [] +synonym: "dCTP catabolism" EXACT [] +synonym: "dCTP degradation" EXACT [] +is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046065 ! dCTP metabolic process + +[Term] +id: GO:0006254 +name: CTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "CTP breakdown" EXACT [] +synonym: "CTP catabolism" EXACT [] +synonym: "CTP degradation" EXACT [] +synonym: "CTP hydrolysis" EXACT [] +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0046036 ! CTP metabolic process + +[Term] +id: GO:0006255 +name: UDP reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0051062 + +[Term] +id: GO:0006256 +name: UDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "UDP breakdown" EXACT [] +synonym: "UDP catabolism" EXACT [] +synonym: "UDP degradation" EXACT [] +is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process +is_a: GO:0046048 ! UDP metabolic process + +[Term] +id: GO:0006257 +name: dUDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dUDP breakdown" EXACT [] +synonym: "dUDP catabolism" EXACT [] +synonym: "dUDP degradation" EXACT [] +is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046077 ! dUDP metabolic process + +[Term] +id: GO:0006258 +name: UDP-glucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-glucose breakdown" EXACT [] +synonym: "UDP-glucose catabolism" EXACT [] +synonym: "UDP-glucose degradation" EXACT [] +is_a: GO:0006011 ! UDP-glucose metabolic process +is_a: GO:0009227 ! nucleotide-sugar catabolic process + +[Term] +id: GO:0006259 +name: DNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "DNA metabolism" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0034960 ! cellular biopolymer metabolic process + +[Term] +id: GO:0006260 +name: DNA replication +namespace: biological_process +def: "The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. +subset: goslim_pir +subset: gosubset_prok +synonym: "DNA biosynthesis" RELATED [] +synonym: "DNA biosynthetic process" RELATED [] +synonym: "DNA synthesis" RELATED [] +xref: Reactome:176101 +xref: Reactome:176116 +xref: Reactome:176175 +xref: Reactome:176187 +xref: Reactome:176250 +xref: Reactome:176264 +xref: Reactome:176298 +xref: Reactome:176318 +xref: Reactome:204211 +xref: Reactome:205947 +xref: Reactome:209363 +xref: Reactome:210696 +xref: Reactome:210713 +xref: Reactome:211049 +xref: Reactome:211609 +xref: Reactome:213204 +xref: Reactome:215512 +xref: Reactome:219112 +xref: Reactome:220587 +xref: Reactome:220604 +xref: Reactome:220896 +xref: Reactome:221383 +xref: Reactome:222984 +xref: Reactome:224670 +xref: Reactome:227905 +xref: Reactome:229236 +xref: Reactome:229253 +xref: Reactome:229565 +xref: Reactome:230019 +xref: Reactome:231470 +xref: Reactome:236114 +xref: Reactome:237238 +xref: Reactome:238037 +xref: Reactome:239451 +xref: Reactome:243273 +xref: Reactome:244047 +xref: Reactome:244652 +xref: Reactome:249742 +xref: Reactome:252497 +xref: Reactome:255670 +xref: Reactome:259062 +xref: Reactome:262424 +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0034961 ! cellular biopolymer biosynthetic process + +[Term] +id: GO:0006261 +name: DNA-dependent DNA replication +namespace: biological_process +alt_id: GO:0006262 +alt_id: GO:0006263 +def: "The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0006264 +name: mitochondrial DNA replication +namespace: biological_process +def: "The process whereby new strands of DNA are synthesized in the mitochondrion." [GOC:ai] +synonym: "mitochondrial DNA synthesis" RELATED [] +synonym: "mtDNA replication" EXACT [] +synonym: "mtDNA synthesis" RELATED [] +synonym: "replication of mitochondrial DNA" EXACT [] +is_a: GO:0006261 ! DNA-dependent DNA replication +is_a: GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:0006265 +name: DNA topological change +namespace: biological_process +def: "The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] +comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. +subset: gosubset_prok +synonym: "DNA conformation modification" EXACT [] +synonym: "DNA underwinding" NARROW [] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0006266 +name: DNA ligation +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0006267 +name: pre-replicative complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, multiprotein complex that forms at eukaryotic DNA replication origins during late M phase; its presence is required for replication initiation." [GOC:mah] +subset: gosubset_prok +synonym: "pre-replicative complex formation" EXACT [] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006268 +name: DNA unwinding during replication +namespace: biological_process +def: "The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194] +subset: gosubset_prok +synonym: "DNA unwinding factor" RELATED [] +is_a: GO:0032508 ! DNA duplex unwinding +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006269 +name: DNA replication, synthesis of RNA primer +namespace: biological_process +def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] +subset: gosubset_prok +synonym: "replication priming" RELATED [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006270 +name: DNA replication initiation +namespace: biological_process +def: "The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006271 +name: DNA strand elongation during DNA replication +namespace: biological_process +def: "The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194] +subset: gosubset_prok +synonym: "DNA replication elongation" EXACT [] +is_a: GO:0022616 ! DNA strand elongation +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006272 +name: leading strand elongation +namespace: biological_process +def: "The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork." [ISBN:071673706X, ISBN:0815316194] +subset: gosubset_prok +is_a: GO:0006271 ! DNA strand elongation during DNA replication + +[Term] +id: GO:0006273 +name: lagging strand elongation +namespace: biological_process +def: "The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [ISBN:071673706X, ISBN:0815316194] +subset: gosubset_prok +is_a: GO:0006271 ! DNA strand elongation during DNA replication + +[Term] +id: GO:0006274 +name: DNA replication termination +namespace: biological_process +def: "The process by which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006275 +name: regulation of DNA replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006260 ! DNA replication + +[Term] +id: GO:0006276 +name: plasmid maintenance +namespace: biological_process +def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0006277 +name: DNA amplification +namespace: biological_process +def: "The process by which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464] +subset: gosubset_prok +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0006278 +name: RNA-dependent DNA replication +namespace: biological_process +def: "The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: Reactome:162589 +xref: Reactome:164516 +xref: Reactome:164525 +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0006279 +name: premeiotic DNA synthesis +namespace: biological_process +def: "The replication of DNA that precedes meiotic cell division." [GOC:ai] +synonym: "meiotic DNA replication" EXACT [] +synonym: "meiotic DNA synthesis" EXACT [] +synonym: "premeiotic DNA replication" EXACT [] +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0006280 +name: mutagenesis +namespace: biological_process +def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent. +subset: gosubset_prok +is_obsolete: true +consider: GO:0006281 +consider: GO:0051276 + +[Term] +id: GO:0006281 +name: DNA repair +namespace: biological_process +def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] +subset: goslim_pir +subset: gosubset_prok +xref: Reactome:211856 +xref: Reactome:212077 +xref: Reactome:221621 +xref: Reactome:221835 +xref: Reactome:230215 +xref: Reactome:230400 +xref: Reactome:238255 +xref: Reactome:238446 +xref: Reactome:244827 +xref: Reactome:244986 +xref: Reactome:249726 +xref: Reactome:249863 +xref: Reactome:252611 +xref: Reactome:255661 +xref: Reactome:255776 +xref: Reactome:259050 +xref: Reactome:259167 +xref: Reactome:262414 +xref: Reactome:262525 +xref: Reactome:265253 +xref: Reactome:265355 +xref: Reactome:268383 +xref: Reactome:268483 +xref: Reactome:274226 +xref: Reactome:274239 +xref: Reactome:280695 +xref: Reactome:282916 +xref: Reactome:286582 +xref: Reactome:286697 +xref: Reactome:288391 +xref: Reactome:289825 +xref: Reactome:289866 +xref: Reactome:290370 +xref: Reactome:290403 +xref: Reactome:291735 +xref: Reactome:291787 +xref: Reactome:292397 +xref: Reactome:292434 +xref: Reactome:293712 +xref: Reactome:293765 +xref: Reactome:73894 +xref: Reactome:73942 +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0034984 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0006282 +name: regulation of DNA repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0006283 +name: transcription-coupled nucleotide-excision repair +namespace: biological_process +def: "The preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the general nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] +subset: gosubset_prok +xref: Reactome:211917 +xref: Reactome:221682 +xref: Reactome:230269 +xref: Reactome:238308 +xref: Reactome:244870 +xref: Reactome:249760 +xref: Reactome:252508 +xref: Reactome:255682 +xref: Reactome:259078 +xref: Reactome:262436 +xref: Reactome:265273 +xref: Reactome:268397 +xref: Reactome:274110 +xref: Reactome:280583 +xref: Reactome:282837 +xref: Reactome:286601 +xref: Reactome:288301 +xref: Reactome:289865 +xref: Reactome:290401 +xref: Reactome:292431 +xref: Reactome:293764 +xref: Reactome:73937 +is_a: GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006284 +name: base-excision repair +namespace: biological_process +def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] +subset: gosubset_prok +synonym: "BER" EXACT [] +xref: Reactome:212109 +xref: Reactome:221868 +xref: Reactome:230447 +xref: Reactome:238477 +xref: Reactome:245023 +xref: Reactome:249910 +xref: Reactome:252629 +xref: Reactome:255812 +xref: Reactome:259200 +xref: Reactome:262558 +xref: Reactome:265382 +xref: Reactome:268518 +xref: Reactome:274238 +xref: Reactome:280706 +xref: Reactome:282917 +xref: Reactome:286728 +xref: Reactome:288393 +xref: Reactome:289891 +xref: Reactome:290423 +xref: Reactome:291803 +xref: Reactome:292445 +xref: Reactome:293783 +xref: Reactome:73884 +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006285 +name: base-excision repair, AP site formation +namespace: biological_process +def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] +subset: gosubset_prok +xref: Reactome:212106 +xref: Reactome:221865 +xref: Reactome:230436 +xref: Reactome:238474 +xref: Reactome:245015 +xref: Reactome:249901 +xref: Reactome:252617 +xref: Reactome:255802 +xref: Reactome:259195 +xref: Reactome:262553 +xref: Reactome:265377 +xref: Reactome:268508 +xref: Reactome:274232 +xref: Reactome:280701 +xref: Reactome:282904 +xref: Reactome:286724 +xref: Reactome:288381 +xref: Reactome:289881 +xref: Reactome:290412 +xref: Reactome:291797 +xref: Reactome:292442 +xref: Reactome:293778 +xref: Reactome:73929 +is_a: GO:0006308 ! DNA catabolic process +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006286 +name: base-excision repair, base-free sugar-phosphate removal +namespace: biological_process +def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194] +subset: gosubset_prok +xref: Reactome:110375 +xref: Reactome:207842 +xref: Reactome:217379 +xref: Reactome:234753 +xref: Reactome:285128 +xref: Reactome:291211 +xref: Reactome:293216 +is_a: GO:0006308 ! DNA catabolic process +is_a: GO:0016311 ! dephosphorylation +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006287 +name: base-excision repair, gap-filling +namespace: biological_process +def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006288 +name: base-excision repair, DNA ligation +namespace: biological_process +def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131] +subset: gosubset_prok +xref: Reactome:110370 +xref: Reactome:207477 +xref: Reactome:209333 +xref: Reactome:217110 +xref: Reactome:219097 +xref: Reactome:234563 +xref: Reactome:236081 +xref: Reactome:258025 +xref: Reactome:261598 +xref: Reactome:264479 +xref: Reactome:272909 +xref: Reactome:279336 +xref: Reactome:285051 +xref: Reactome:73931 +is_a: GO:0051103 ! DNA ligation during DNA repair +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006289 +name: nucleotide-excision repair +namespace: biological_process +alt_id: GO:0045001 +def: "In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] +comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. +subset: gosubset_prok +synonym: "interstrand crosslink repair" NARROW [] +synonym: "intrastrand cross-link repair" RELATED [] +synonym: "NER" EXACT [] +synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] +xref: Reactome:212087 +xref: Reactome:221845 +xref: Reactome:230413 +xref: Reactome:238455 +xref: Reactome:244997 +xref: Reactome:249879 +xref: Reactome:252598 +xref: Reactome:255784 +xref: Reactome:259178 +xref: Reactome:262534 +xref: Reactome:265361 +xref: Reactome:268490 +xref: Reactome:274215 +xref: Reactome:280684 +xref: Reactome:282893 +xref: Reactome:286704 +xref: Reactome:288368 +xref: Reactome:289886 +xref: Reactome:290417 +xref: Reactome:292443 +xref: Reactome:293781 +xref: Reactome:73885 +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006290 +name: pyrimidine dimer repair +namespace: biological_process +def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006291 +name: pyrimidine-dimer repair, DNA damage excision +namespace: biological_process +def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194] +comment: This term was made obsolete because this process can be subdivided into multiple processes. +is_obsolete: true +consider: GO:0006289 + +[Term] +id: GO:0006292 +name: pyrimidine-dimer repair, DNA damage recognition +namespace: biological_process +def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194] +comment: This term was made obsolete because it is a substrate specific DNA repair process. +is_obsolete: true +consider: GO:0000715 +consider: GO:0000716 + +[Term] +id: GO:0006293 +name: nucleotide-excision repair, preincision complex stabilization +namespace: biological_process +def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] +subset: gosubset_prok +xref: Reactome:109953 +is_a: GO:0031334 ! positive regulation of protein complex assembly +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006294 +name: nucleotide-excision repair, preincision complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] +subset: gosubset_prok +synonym: "nucleotide-excision repair, preincision complex formation" EXACT [] +xref: Reactome:73936 +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006295 +name: nucleotide-excision repair, DNA incision, 3'-to lesion +namespace: biological_process +def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977] +subset: gosubset_prok +synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT [] +xref: Reactome:203599 +xref: Reactome:212566 +xref: Reactome:230921 +xref: Reactome:238961 +xref: Reactome:245314 +xref: Reactome:250129 +xref: Reactome:252827 +xref: Reactome:256058 +xref: Reactome:259419 +xref: Reactome:268931 +xref: Reactome:274736 +xref: Reactome:73938 +is_a: GO:0033683 ! nucleotide-excision repair, DNA incision + +[Term] +id: GO:0006296 +name: nucleotide-excision repair, DNA incision, 5'-to lesion +namespace: biological_process +def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977] +subset: gosubset_prok +synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT [] +xref: Reactome:73939 +is_a: GO:0033683 ! nucleotide-excision repair, DNA incision + +[Term] +id: GO:0006297 +name: nucleotide-excision repair, DNA gap filling +namespace: biological_process +def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194] +subset: gosubset_prok +xref: Reactome:211846 +xref: Reactome:221611 +xref: Reactome:230207 +xref: Reactome:238245 +xref: Reactome:244816 +xref: Reactome:249713 +xref: Reactome:252483 +xref: Reactome:255648 +xref: Reactome:259040 +xref: Reactome:262406 +xref: Reactome:265246 +xref: Reactome:268374 +xref: Reactome:274083 +xref: Reactome:280557 +xref: Reactome:282820 +xref: Reactome:286571 +xref: Reactome:288289 +xref: Reactome:289823 +xref: Reactome:290367 +xref: Reactome:292393 +xref: Reactome:293709 +xref: Reactome:74969 +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006298 +name: mismatch repair +namespace: biological_process +alt_id: GO:0006300 +def: "A system for the correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11687886] +subset: gosubset_prok +synonym: "long patch mismatch repair system" NARROW [] +synonym: "mismatch repair, MutL-like pathway" RELATED [] +synonym: "MMR" EXACT [] +synonym: "MutS/MutL/MutH pathway" RELATED [] +is_a: GO:0006281 ! DNA repair +is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication + +[Term] +id: GO:0006299 +name: short patch mismatch repair system +namespace: biological_process +def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254] +comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. +is_obsolete: true +consider: GO:0006284 +consider: GO:0006289 + +[Term] +id: GO:0006301 +name: postreplication repair +namespace: biological_process +def: "Pathways for DNA repair which occur after DNA has replicated, e.g. mismatch repair, and which involve translesion synthesis (TLS-type) DNA polymerases." [GOC:ai, ISBN:0716735202, PMID:12154119] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006302 +name: double-strand break repair +namespace: biological_process +def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] +subset: gosubset_prok +xref: Reactome:211994 +xref: Reactome:221758 +xref: Reactome:230339 +xref: Reactome:238375 +xref: Reactome:244932 +xref: Reactome:249918 +xref: Reactome:252555 +xref: Reactome:255732 +xref: Reactome:259126 +xref: Reactome:262483 +xref: Reactome:265390 +xref: Reactome:268526 +xref: Reactome:274159 +xref: Reactome:280632 +xref: Reactome:282923 +xref: Reactome:286651 +xref: Reactome:288400 +xref: Reactome:289895 +xref: Reactome:290426 +xref: Reactome:73890 +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006303 +name: double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends." [PMID:10827453] +subset: gosubset_prok +synonym: "NHEJ" EXACT [] +xref: Reactome:211656 +xref: Reactome:221428 +xref: Reactome:230060 +xref: Reactome:238080 +xref: Reactome:244696 +xref: Reactome:252411 +xref: Reactome:255571 +xref: Reactome:258946 +xref: Reactome:262319 +xref: Reactome:273984 +xref: Reactome:280463 +xref: Reactome:286483 +xref: Reactome:73889 +is_a: GO:0000726 ! non-recombinational repair +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0006304 +name: DNA modification +namespace: biological_process +def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0043412 ! biopolymer modification + +[Term] +id: GO:0006305 +name: DNA alkylation +namespace: biological_process +def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] +subset: gosubset_prok +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0006306 +name: DNA methylation +namespace: biological_process +def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006305 ! DNA alkylation +is_a: GO:0040029 ! regulation of gene expression, epigenetic +is_a: GO:0043414 ! biopolymer methylation + +[Term] +id: GO:0006307 +name: DNA dealkylation +namespace: biological_process +def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226] +subset: gosubset_prok +xref: Reactome:112122 +xref: Reactome:112126 +xref: Reactome:209544 +xref: Reactome:211876 +xref: Reactome:211877 +xref: Reactome:212080 +xref: Reactome:219289 +xref: Reactome:221641 +xref: Reactome:221642 +xref: Reactome:221838 +xref: Reactome:228099 +xref: Reactome:230234 +xref: Reactome:230235 +xref: Reactome:230403 +xref: Reactome:236309 +xref: Reactome:238272 +xref: Reactome:238273 +xref: Reactome:238448 +xref: Reactome:243457 +xref: Reactome:248543 +xref: Reactome:254903 +xref: Reactome:258169 +xref: Reactome:259057 +xref: Reactome:259169 +xref: Reactome:261697 +xref: Reactome:264565 +xref: Reactome:267681 +xref: Reactome:268387 +xref: Reactome:268388 +xref: Reactome:268485 +xref: Reactome:274096 +xref: Reactome:274207 +xref: Reactome:285672 +xref: Reactome:289549 +xref: Reactome:290244 +xref: Reactome:291427 +xref: Reactome:292243 +xref: Reactome:292399 +xref: Reactome:292435 +xref: Reactome:293427 +xref: Reactome:293716 +xref: Reactome:293766 +xref: Reactome:73892 +xref: Reactome:73943 +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006308 +name: DNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "DNA breakdown" EXACT [] +synonym: "DNA catabolism" EXACT [] +synonym: "DNA degradation" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0043285 ! biopolymer catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0006309 +name: DNA fragmentation during apoptosis +namespace: biological_process +alt_id: GO:0008178 +def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:mah, ISBN:0721639976] +synonym: "DNA catabolic process during apoptosis" EXACT [] +synonym: "DNA catabolism during apoptosis" EXACT [] +synonym: "DNA fragmentation" BROAD [] +xref: Reactome:140342 +is_a: GO:0006308 ! DNA catabolic process +is_a: GO:0006921 ! cell structure disassembly during apoptosis +relationship: part_of GO:0030262 ! apoptotic nuclear changes + +[Term] +id: GO:0006310 +name: DNA recombination +namespace: biological_process +def: "Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0006311 +name: meiotic gene conversion +namespace: biological_process +def: "The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] +synonym: "gene conversion without reciprocal crossover" EXACT [] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0006312 +name: mitotic recombination +namespace: biological_process +def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0006313 +name: transposition, DNA-mediated +namespace: biological_process +alt_id: GO:0006317 +alt_id: GO:0006318 +def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:1555812090] +subset: gosubset_prok +synonym: "Class II transposition" EXACT [] +synonym: "cut-and-paste transposition" EXACT [] +synonym: "DNA transposition" EXACT [GOC:dph] +synonym: "P-element excision" NARROW [] +synonym: "P-element transposition" NARROW [] +synonym: "Tc1/mariner transposition" NARROW [] +synonym: "Tc3 transposition" NARROW [] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0006314 +name: intron homing +namespace: biological_process +def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208] +subset: gosubset_prok +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0006315 +name: homing of group II introns +namespace: biological_process +def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208] +subset: gosubset_prok +is_a: GO:0006314 ! intron homing + +[Term] +id: GO:0006316 +name: movement of group I intron +namespace: biological_process +def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208] +subset: gosubset_prok +is_a: GO:0006314 ! intron homing + +[Term] +id: GO:0006323 +name: DNA packaging +namespace: biological_process +def: "Any process by which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] +subset: goslim_pir +synonym: "DNA organisation" EXACT [] +synonym: "DNA organization" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0006324 +name: S-phase-specific histone modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] +is_a: GO:0016570 ! histone modification +relationship: part_of GO:0051320 ! S phase + +[Term] +id: GO:0006325 +name: establishment or maintenance of chromatin architecture +namespace: biological_process +def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0006326 +name: bent DNA binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0003681 + +[Term] +id: GO:0006327 +name: random coil binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +consider: GO:0003695 + +[Term] +id: GO:0006328 +name: AT binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0003680 + +[Term] +id: GO:0006329 +name: satellite DNA binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0003696 + +[Term] +id: GO:0006330 +name: single-stranded DNA binding +namespace: biological_process +alt_id: GO:0006331 +alt_id: GO:0006332 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0003697 + +[Term] +id: GO:0006333 +name: chromatin assembly or disassembly +namespace: biological_process +def: "The formation or destruction of chromatin structures." [GOC:mah] +synonym: "chromatin assembly/disassembly" EXACT [] +is_a: GO:0006325 ! establishment or maintenance of chromatin architecture + +[Term] +id: GO:0006334 +name: nucleosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] +synonym: "nucleosome modeling" EXACT [] +is_a: GO:0034728 ! nucleosome organization +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0031497 ! chromatin assembly + +[Term] +id: GO:0006335 +name: DNA replication-dependent nucleosome assembly +namespace: biological_process +def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah] +is_a: GO:0006334 ! nucleosome assembly +is_a: GO:0034723 ! DNA replication-dependent nucleosome organization + +[Term] +id: GO:0006336 +name: DNA replication-independent nucleosome assembly +namespace: biological_process +def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] +synonym: "transcription-coupled nucleosome assembly" EXACT [] +is_a: GO:0006334 ! nucleosome assembly +is_a: GO:0034724 ! DNA replication-independent nucleosome organization + +[Term] +id: GO:0006337 +name: nucleosome disassembly +namespace: biological_process +def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] +is_a: GO:0032986 ! protein-DNA complex disassembly +is_a: GO:0034728 ! nucleosome organization +relationship: part_of GO:0031498 ! chromatin disassembly + +[Term] +id: GO:0006338 +name: chromatin remodeling +namespace: biological_process +def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jic, PMID:12697820] +synonym: "chromatin modeling" EXACT [] +synonym: "chromatin modelling" EXACT [] +synonym: "chromatin remodelling" EXACT [] +is_a: GO:0016568 ! chromatin modification + +[Term] +id: GO:0006339 +name: positive regulation of transcription of homeotic gene (trithorax group) +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +is_obsolete: true +consider: GO:0006342 +consider: GO:0048096 + +[Term] +id: GO:0006340 +name: negative regulation of transcription of homeotic gene (Polycomb group) +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +is_obsolete: true +consider: GO:0006342 +consider: GO:0048096 + +[Term] +id: GO:0006341 +name: chromatin insulator sequence binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0043035 + +[Term] +id: GO:0006342 +name: chromatin silencing +namespace: biological_process +alt_id: GO:0016440 +def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] +comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription. +synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT [] +synonym: "chromatin-mediated silencing" EXACT [] +synonym: "heterochromatic silencing" RELATED [] +synonym: "TGS" EXACT [] +synonym: "transcriptional gene silencing" EXACT [] +is_a: GO:0016458 ! gene silencing +is_a: GO:0045814 ! negative regulation of gene expression, epigenetic +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent + +[Term] +id: GO:0006343 +name: establishment of chromatin silencing +namespace: biological_process +def: "The initial formation of transcriptionally silent heterochromatin." [GOC:mah] +synonym: "establishment of heterochromatic silencing" EXACT [] +is_a: GO:0031507 ! heterochromatin formation +relationship: part_of GO:0006342 ! chromatin silencing + +[Term] +id: GO:0006344 +name: maintenance of chromatin silencing +namespace: biological_process +def: "The maintenance of chromatin in a transciptionally silent heterochromatin state." [GOC:mah] +synonym: "maintenance of heterochromatic silencing" EXACT [] +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0006342 ! chromatin silencing + +[Term] +id: GO:0006345 +name: loss of chromatin silencing +namespace: biological_process +def: "The process leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:go_curators] +is_a: GO:0031936 ! negative regulation of chromatin silencing + +[Term] +id: GO:0006346 +name: methylation-dependent chromatin silencing +namespace: biological_process +def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah] +synonym: "methylation-dependent heterochromatic silencing" EXACT [] +is_a: GO:0006342 ! chromatin silencing +is_a: GO:0016569 ! covalent chromatin modification + +[Term] +id: GO:0006348 +name: chromatin silencing at telomere +namespace: biological_process +def: "Repression of transcription of telomeric DNA by the formation of heterochromatin." [PMID:10219245] +synonym: "heterochromatic silencing at telomere" EXACT [] +is_a: GO:0006342 ! chromatin silencing +is_a: GO:0031509 ! telomeric heterochromatin formation + +[Term] +id: GO:0006349 +name: genetic imprinting +namespace: biological_process +def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11498578] +synonym: "DNA imprinting" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0006350 +name: transcription +namespace: biological_process +def: "The synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +xref: Reactome:212088 +xref: Reactome:221846 +xref: Reactome:230414 +xref: Reactome:238456 +xref: Reactome:244998 +xref: Reactome:249880 +xref: Reactome:252609 +xref: Reactome:255785 +xref: Reactome:259179 +xref: Reactome:262535 +xref: Reactome:265362 +xref: Reactome:268499 +xref: Reactome:274216 +xref: Reactome:280685 +xref: Reactome:282909 +xref: Reactome:286705 +xref: Reactome:288376 +xref: Reactome:74159 +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0034961 ! cellular biopolymer biosynthetic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0006351 +name: transcription, DNA-dependent +namespace: biological_process +def: "The synthesis of RNA on a template of DNA." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006350 ! transcription +is_a: GO:0032774 ! RNA biosynthetic process + +[Term] +id: GO:0006352 +name: transcription initiation +namespace: biological_process +def: "Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter." [GOC:jic] +subset: gosubset_prok +synonym: "RNA polymerase complex assembly at promoter" EXACT [] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006353 +name: transcription termination +namespace: biological_process +def: "The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [ISBN:0716720094] +subset: gosubset_prok +synonym: "transcriptional complex disassembly" EXACT [] +is_a: GO:0043624 ! cellular protein complex disassembly +relationship: part_of GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006354 +name: RNA elongation +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "transcription elongation" BROAD [] +synonym: "transcriptional elongation" BROAD [] +is_a: GO:0016070 ! RNA metabolic process +relationship: part_of GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006355 +name: regulation of transcription, DNA-dependent +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA-dependent transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "transcriptional control" BROAD [] +is_a: GO:0045449 ! regulation of transcription +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006356 +name: regulation of transcription from RNA polymerase I promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators] +synonym: "regulation of transcription from Pol I promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +relationship: regulates GO:0006360 ! transcription from RNA polymerase I promoter + +[Term] +id: GO:0006357 +name: regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "regulation of transcription from Pol II promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0006358 +name: regulation of transcription from RNA polymerase II promoter, global +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of global transcription from Pol II promoter." [GOC:go_curators] +synonym: "global transcription regulation from Pol II promoter" EXACT [] +synonym: "regulation of global transcription from Pol II promoter" EXACT [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0006359 +name: regulation of transcription from RNA polymerase III promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators] +synonym: "regulation of transcription from Pol III promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +relationship: regulates GO:0006383 ! transcription from RNA polymerase III promoter + +[Term] +id: GO:0006360 +name: transcription from RNA polymerase I promoter +namespace: biological_process +def: "The synthesis of RNA from a DNA template by RNA polymerase I (Pol I), originating at a Pol I-specific promoter." [GOC:jl] +synonym: "transcription from Pol I promoter" EXACT [] +xref: Reactome:212045 +xref: Reactome:221808 +xref: Reactome:230416 +xref: Reactome:238420 +xref: Reactome:245011 +xref: Reactome:249846 +xref: Reactome:252614 +xref: Reactome:255758 +xref: Reactome:259152 +xref: Reactome:262509 +xref: Reactome:265372 +xref: Reactome:268502 +xref: Reactome:274187 +xref: Reactome:280660 +xref: Reactome:286679 +xref: Reactome:288378 +xref: Reactome:73864 +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006361 +name: transcription initiation from RNA polymerase I promoter +namespace: biological_process +synonym: "transcription initiation from Pol I promoter" EXACT [] +xref: Reactome:211654 +xref: Reactome:221426 +xref: Reactome:230100 +xref: Reactome:238079 +xref: Reactome:244718 +xref: Reactome:249615 +xref: Reactome:252425 +xref: Reactome:255570 +xref: Reactome:258945 +xref: Reactome:262318 +xref: Reactome:265183 +xref: Reactome:268296 +xref: Reactome:273977 +xref: Reactome:280456 +xref: Reactome:286478 +xref: Reactome:288245 +xref: Reactome:73762 +is_a: GO:0006352 ! transcription initiation +relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter + +[Term] +id: GO:0006362 +name: RNA elongation from RNA polymerase I promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase I-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah] +synonym: "RNA elongation from Pol I promoter" EXACT [] +xref: Reactome:211786 +xref: Reactome:221551 +xref: Reactome:238191 +xref: Reactome:249680 +xref: Reactome:255622 +xref: Reactome:259007 +xref: Reactome:262377 +xref: Reactome:274046 +xref: Reactome:280524 +xref: Reactome:286547 +xref: Reactome:73777 +is_a: GO:0006354 ! RNA elongation +relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter + +[Term] +id: GO:0006363 +name: termination of RNA polymerase I transcription +namespace: biological_process +alt_id: GO:0019223 +def: "The process by which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed; typically occurs within U-rich regions." [GOC:mah, PMID:12944462] +synonym: "RNA polymerase I transcription termination" EXACT [] +synonym: "transcription termination from Pol I promoter" EXACT [] +synonym: "transcription termination from RNA polymerase I promoter" EXACT [] +xref: Reactome:211897 +xref: Reactome:221661 +xref: Reactome:230285 +xref: Reactome:238288 +xref: Reactome:73863 +is_a: GO:0006353 ! transcription termination +relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter + +[Term] +id: GO:0006364 +name: rRNA processing +namespace: biological_process +alt_id: GO:0006365 +def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] +subset: gosubset_prok +synonym: "35S primary transcript processing" NARROW [] +is_a: GO:0016072 ! rRNA metabolic process +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0006366 +name: transcription from RNA polymerase II promoter +namespace: biological_process +def: "The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, ISBN:0321000382] +synonym: "transcription from Pol II promoter" EXACT [] +xref: Reactome:211919 +xref: Reactome:221684 +xref: Reactome:230271 +xref: Reactome:238311 +xref: Reactome:244872 +xref: Reactome:249762 +xref: Reactome:252544 +xref: Reactome:255684 +xref: Reactome:259080 +xref: Reactome:262438 +xref: Reactome:265275 +xref: Reactome:268432 +xref: Reactome:274112 +xref: Reactome:280585 +xref: Reactome:286603 +xref: Reactome:288327 +xref: Reactome:73857 +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006367 +name: transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process involved in starting transcription from the RNA polymerase II promoter." [GOC:jic] +synonym: "transcription initiation from Pol II promoter" EXACT [] +xref: Reactome:167161 +xref: Reactome:211863 +xref: Reactome:221628 +xref: Reactome:230221 +xref: Reactome:238260 +xref: Reactome:244832 +xref: Reactome:249731 +xref: Reactome:255664 +xref: Reactome:259054 +xref: Reactome:262417 +xref: Reactome:265256 +xref: Reactome:274092 +xref: Reactome:280567 +xref: Reactome:286585 +xref: Reactome:75953 +is_a: GO:0006352 ! transcription initiation +relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0006368 +name: RNA elongation from RNA polymerase II promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase II-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah] +synonym: "RNA elongation from Pol II promoter" EXACT [] +xref: Reactome:167169 +xref: Reactome:211622 +xref: Reactome:221396 +xref: Reactome:230030 +xref: Reactome:238048 +xref: Reactome:244663 +xref: Reactome:249844 +xref: Reactome:255756 +xref: Reactome:259150 +xref: Reactome:262507 +xref: Reactome:265336 +xref: Reactome:274185 +xref: Reactome:280658 +xref: Reactome:286677 +xref: Reactome:288348 +xref: Reactome:75955 +is_a: GO:0006354 ! RNA elongation +relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0006369 +name: termination of RNA polymerase II transcription +namespace: biological_process +alt_id: GO:0019224 +def: "The process by which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah] +synonym: "RNA polymerase II transcription termination" EXACT [] +synonym: "transcription termination from Pol II promoter" EXACT [] +synonym: "transcription termination from RNA polymerase II promoter" EXACT [] +xref: Reactome:167168 +xref: Reactome:212031 +xref: Reactome:221794 +xref: Reactome:244958 +xref: Reactome:286670 +xref: Reactome:73856 +is_a: GO:0006353 ! transcription termination +relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0006370 +name: mRNA capping +namespace: biological_process +def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] +comment: See also the biological process term 'RNA capping ; GO:0009452'. +synonym: "5' end capping" EXACT [] +synonym: "5' mRNA capping" EXACT [] +synonym: "5'-end mRNA processing" EXACT [] +synonym: "5'-end processing" BROAD [] +xref: Reactome:211717 +xref: Reactome:221487 +xref: Reactome:230111 +xref: Reactome:238133 +xref: Reactome:244728 +xref: Reactome:249639 +xref: Reactome:252428 +xref: Reactome:255589 +xref: Reactome:258966 +xref: Reactome:262338 +xref: Reactome:265186 +xref: Reactome:274006 +xref: Reactome:280485 +xref: Reactome:286505 +xref: Reactome:72086 +is_a: GO:0006397 ! mRNA processing +is_a: GO:0009452 ! RNA capping + +[Term] +id: GO:0006371 +name: mRNA splicing +namespace: biological_process +def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents several different processes. +is_obsolete: true +consider: GO:0000372 +consider: GO:0000373 +consider: GO:0000374 +consider: GO:0000394 +consider: GO:0000398 + +[Term] +id: GO:0006372 +name: lariat formation, 5'-splice site cleavage +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +consider: GO:0000350 +consider: GO:0000386 + +[Term] +id: GO:0006373 +name: 3'-splice site cleavage, exon ligation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +consider: GO:0000386 +consider: GO:0000388 +consider: GO:0000393 + +[Term] +id: GO:0006376 +name: mRNA splice site selection +namespace: biological_process +def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] +synonym: "spliceosomal commitment complex biosynthesis" NARROW [] +synonym: "spliceosomal commitment complex formation" NARROW [] +synonym: "spliceosomal E complex biosynthesis" NARROW [] +synonym: "spliceosomal E complex formation" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosome assembly + +[Term] +id: GO:0006377 +name: MATa1 (A1) pre-mRNA splicing +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. +is_obsolete: true +consider: GO:0000244 + +[Term] +id: GO:0006378 +name: mRNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cleavage and polyadenylylation specificity factor activity" NARROW [] +synonym: "mRNA polyadenylylation" EXACT [] +xref: Reactome:209549 +xref: Reactome:219294 +xref: Reactome:243459 +xref: Reactome:248545 +xref: Reactome:72185 +is_a: GO:0031124 ! mRNA 3'-end processing +is_a: GO:0043631 ! RNA polyadenylation + +[Term] +id: GO:0006379 +name: mRNA cleavage +namespace: biological_process +def: "Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] +subset: gosubset_prok +synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] +synonym: "cleavage stimulation factor activity" RELATED [] +synonym: "pre-mRNA cleavage factor activity" RELATED [] +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0006380 +name: poly-A binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +consider: GO:0008143 + +[Term] +id: GO:0006382 +name: adenosine to inosine editing +namespace: biological_process +def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] +subset: gosubset_prok +xref: Reactome:212011 +xref: Reactome:221775 +xref: Reactome:238390 +xref: Reactome:268450 +xref: Reactome:75064 +is_a: GO:0016553 ! base conversion or substitution editing + +[Term] +id: GO:0006383 +name: transcription from RNA polymerase III promoter +namespace: biological_process +def: "The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter." [GOC:jl] +subset: gosubset_prok +synonym: "transcription from Pol III promoter" EXACT [] +xref: Reactome:112054 +xref: Reactome:112055 +xref: Reactome:112149 +xref: Reactome:112153 +xref: Reactome:112155 +xref: Reactome:112156 +xref: Reactome:113442 +xref: Reactome:113446 +xref: Reactome:113451 +xref: Reactome:113705 +xref: Reactome:209117 +xref: Reactome:210862 +xref: Reactome:210890 +xref: Reactome:210892 +xref: Reactome:210894 +xref: Reactome:210895 +xref: Reactome:210896 +xref: Reactome:210899 +xref: Reactome:210900 +xref: Reactome:210901 +xref: Reactome:210902 +xref: Reactome:212063 +xref: Reactome:218844 +xref: Reactome:220712 +xref: Reactome:220733 +xref: Reactome:220735 +xref: Reactome:220737 +xref: Reactome:220738 +xref: Reactome:220739 +xref: Reactome:220742 +xref: Reactome:220743 +xref: Reactome:220744 +xref: Reactome:220745 +xref: Reactome:221826 +xref: Reactome:227651 +xref: Reactome:229391 +xref: Reactome:229406 +xref: Reactome:229408 +xref: Reactome:229410 +xref: Reactome:229411 +xref: Reactome:229412 +xref: Reactome:229415 +xref: Reactome:229416 +xref: Reactome:229417 +xref: Reactome:229418 +xref: Reactome:230394 +xref: Reactome:235872 +xref: Reactome:237412 +xref: Reactome:237446 +xref: Reactome:237448 +xref: Reactome:237450 +xref: Reactome:237451 +xref: Reactome:237452 +xref: Reactome:237455 +xref: Reactome:237456 +xref: Reactome:237457 +xref: Reactome:237458 +xref: Reactome:238433 +xref: Reactome:243049 +xref: Reactome:244155 +xref: Reactome:244176 +xref: Reactome:244178 +xref: Reactome:244179 +xref: Reactome:244180 +xref: Reactome:244182 +xref: Reactome:244183 +xref: Reactome:244184 +xref: Reactome:244976 +xref: Reactome:248196 +xref: Reactome:249198 +xref: Reactome:249219 +xref: Reactome:249221 +xref: Reactome:249222 +xref: Reactome:249226 +xref: Reactome:249228 +xref: Reactome:249229 +xref: Reactome:249230 +xref: Reactome:249855 +xref: Reactome:251616 +xref: Reactome:252099 +xref: Reactome:252131 +xref: Reactome:252132 +xref: Reactome:252137 +xref: Reactome:252138 +xref: Reactome:252584 +xref: Reactome:255765 +xref: Reactome:257936 +xref: Reactome:258620 +xref: Reactome:258639 +xref: Reactome:258640 +xref: Reactome:259161 +xref: Reactome:261528 +xref: Reactome:262024 +xref: Reactome:262053 +xref: Reactome:262055 +xref: Reactome:262056 +xref: Reactome:262060 +xref: Reactome:262065 +xref: Reactome:262066 +xref: Reactome:262067 +xref: Reactome:262518 +xref: Reactome:267451 +xref: Reactome:267982 +xref: Reactome:267996 +xref: Reactome:267997 +xref: Reactome:268472 +xref: Reactome:272748 +xref: Reactome:273552 +xref: Reactome:273584 +xref: Reactome:273586 +xref: Reactome:273587 +xref: Reactome:273591 +xref: Reactome:273596 +xref: Reactome:273597 +xref: Reactome:273598 +xref: Reactome:274196 +xref: Reactome:279017 +xref: Reactome:280021 +xref: Reactome:280050 +xref: Reactome:280052 +xref: Reactome:280053 +xref: Reactome:280057 +xref: Reactome:280062 +xref: Reactome:280063 +xref: Reactome:280064 +xref: Reactome:280668 +xref: Reactome:282204 +xref: Reactome:282618 +xref: Reactome:282635 +xref: Reactome:282636 +xref: Reactome:282878 +xref: Reactome:285455 +xref: Reactome:286132 +xref: Reactome:286151 +xref: Reactome:286153 +xref: Reactome:286154 +xref: Reactome:286158 +xref: Reactome:286160 +xref: Reactome:286161 +xref: Reactome:286162 +xref: Reactome:286687 +xref: Reactome:287828 +xref: Reactome:288011 +xref: Reactome:288026 +xref: Reactome:288027 +xref: Reactome:288353 +xref: Reactome:74158 +xref: Reactome:76060 +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0006384 +name: transcription initiation from RNA polymerase III promoter +namespace: biological_process +synonym: "transcription initiation from Pol III promoter" EXACT [] +is_a: GO:0006352 ! transcription initiation +relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter + +[Term] +id: GO:0006385 +name: RNA elongation from RNA polymerase III promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase III-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah] +synonym: "RNA elongation from Pol III promoter" EXACT [] +xref: Reactome:211834 +xref: Reactome:221599 +xref: Reactome:230198 +xref: Reactome:238232 +xref: Reactome:244808 +xref: Reactome:249708 +xref: Reactome:252479 +xref: Reactome:255641 +xref: Reactome:259035 +xref: Reactome:262400 +xref: Reactome:268365 +xref: Reactome:274075 +xref: Reactome:280549 +xref: Reactome:282819 +xref: Reactome:286567 +xref: Reactome:288283 +xref: Reactome:73780 +is_a: GO:0006354 ! RNA elongation +relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter + +[Term] +id: GO:0006386 +name: termination of RNA polymerase III transcription +namespace: biological_process +alt_id: GO:0019225 +def: "The process by which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462] +synonym: "RNA polymerase III transcription termination" EXACT [] +synonym: "transcription termination from Pol III promoter" EXACT [] +synonym: "transcription termination from RNA polymerase III promoter" EXACT [] +xref: Reactome:112466 +xref: Reactome:112480 +xref: Reactome:113454 +xref: Reactome:210922 +xref: Reactome:211921 +xref: Reactome:220770 +xref: Reactome:221686 +xref: Reactome:229433 +xref: Reactome:230273 +xref: Reactome:237464 +xref: Reactome:238313 +xref: Reactome:244196 +xref: Reactome:244874 +xref: Reactome:249241 +xref: Reactome:249765 +xref: Reactome:252142 +xref: Reactome:252511 +xref: Reactome:255689 +xref: Reactome:258644 +xref: Reactome:259082 +xref: Reactome:262071 +xref: Reactome:262442 +xref: Reactome:268004 +xref: Reactome:268399 +xref: Reactome:273602 +xref: Reactome:274116 +xref: Reactome:280075 +xref: Reactome:280589 +xref: Reactome:282643 +xref: Reactome:282839 +xref: Reactome:286169 +xref: Reactome:286606 +xref: Reactome:288029 +xref: Reactome:288303 +xref: Reactome:73980 +is_a: GO:0006353 ! transcription termination +relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter + +[Term] +id: GO:0006387 +name: snRNA capping +namespace: biological_process +is_a: GO:0009452 ! RNA capping +is_a: GO:0016180 ! snRNA processing + +[Term] +id: GO:0006388 +name: tRNA splicing, via endonucleolytic cleavage and ligation +namespace: biological_process +def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] +comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. +subset: gosubset_prok +synonym: "tRNA-Y splicing" NARROW [] +is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation +is_a: GO:0008033 ! tRNA processing + +[Term] +id: GO:0006389 +name: tRNA-Y splicing +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. +is_obsolete: true +consider: GO:0006388 + +[Term] +id: GO:0006390 +name: transcription from mitochondrial promoter +namespace: biological_process +def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] +synonym: "mitochondrial transcription" EXACT [] +xref: Reactome:211999 +xref: Reactome:221763 +xref: Reactome:230345 +xref: Reactome:238380 +xref: Reactome:244937 +xref: Reactome:249884 +xref: Reactome:252600 +xref: Reactome:262537 +xref: Reactome:75944 +is_a: GO:0006351 ! transcription, DNA-dependent +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0006391 +name: transcription initiation from mitochondrial promoter +namespace: biological_process +xref: Reactome:163282 +xref: Reactome:211672 +xref: Reactome:221443 +xref: Reactome:230074 +xref: Reactome:238095 +xref: Reactome:244701 +xref: Reactome:249770 +xref: Reactome:252513 +xref: Reactome:262444 +is_a: GO:0006352 ! transcription initiation +relationship: part_of GO:0006390 ! transcription from mitochondrial promoter + +[Term] +id: GO:0006392 +name: RNA elongation from mitochondrial promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah] +is_a: GO:0006354 ! RNA elongation +relationship: part_of GO:0006390 ! transcription from mitochondrial promoter + +[Term] +id: GO:0006393 +name: termination of mitochondrial transcription +namespace: biological_process +def: "The process by which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah] +synonym: "mitochondrial transcription termination" EXACT [] +synonym: "RNA transcription termination from mitochondrial promoter" EXACT [] +xref: Reactome:163316 +xref: Reactome:211666 +xref: Reactome:221437 +xref: Reactome:238089 +is_a: GO:0006353 ! transcription termination +relationship: part_of GO:0006390 ! transcription from mitochondrial promoter + +[Term] +id: GO:0006396 +name: RNA processing +namespace: biological_process +alt_id: GO:0006394 +def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0016070 ! RNA metabolic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0006397 +name: mRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] +subset: gosubset_prok +synonym: "mRNA maturation" RELATED [] +xref: Reactome:206758 +xref: Reactome:212012 +xref: Reactome:216307 +xref: Reactome:221776 +xref: Reactome:230353 +xref: Reactome:241665 +xref: Reactome:244946 +xref: Reactome:249825 +xref: Reactome:255781 +xref: Reactome:259174 +xref: Reactome:262531 +xref: Reactome:265358 +xref: Reactome:274212 +xref: Reactome:284708 +xref: Reactome:286661 +xref: Reactome:75067 +xref: Reactome:77586 +is_a: GO:0006396 ! RNA processing +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0006398 +name: histone mRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah] +synonym: "histone mRNA 3' end processing" EXACT [] +is_a: GO:0008334 ! histone mRNA metabolic process +is_a: GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0006399 +name: tRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0006400 +name: tRNA modification +namespace: biological_process +alt_id: GO:0016549 +def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. +subset: gosubset_prok +synonym: "tRNA editing" EXACT [] +is_a: GO:0008033 ! tRNA processing +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0006401 +name: RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "RNA breakdown" EXACT [] +synonym: "RNA catabolism" EXACT [] +synonym: "RNA degradation" EXACT [] +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0043285 ! biopolymer catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0006402 +name: mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mRNA breakdown" EXACT [] +synonym: "mRNA catabolism" EXACT [] +synonym: "mRNA degradation" EXACT [] +is_a: GO:0006401 ! RNA catabolic process +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0006403 +name: RNA localization +namespace: biological_process +def: "A process by which RNA is transported to, or maintained in, a specific location." [GOC:ai] +subset: gosubset_prok +synonym: "establishment and maintenance of RNA localization" EXACT [] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0006404 +name: RNA import into nucleus +namespace: biological_process +def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] +synonym: "RNA import into cell nucleus" EXACT [] +synonym: "RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "RNA-nucleus import" EXACT [] +is_a: GO:0050658 ! RNA transport +is_a: GO:0051170 ! nuclear import + +[Term] +id: GO:0006405 +name: RNA export from nucleus +namespace: biological_process +def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "RNA export from cell nucleus" EXACT [] +synonym: "RNA export out of nucleus" EXACT [] +synonym: "RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "RNA-nucleus export" EXACT [] +xref: Reactome:158441 +xref: Reactome:158447 +xref: Reactome:158481 +xref: Reactome:159101 +xref: Reactome:210719 +xref: Reactome:210819 +xref: Reactome:211324 +xref: Reactome:211326 +xref: Reactome:220610 +xref: Reactome:237378 +xref: Reactome:237784 +xref: Reactome:237787 +xref: Reactome:244059 +xref: Reactome:244143 +xref: Reactome:244447 +xref: Reactome:244449 +xref: Reactome:249112 +is_a: GO:0050658 ! RNA transport +is_a: GO:0051168 ! nuclear export + +[Term] +id: GO:0006406 +name: mRNA export from nucleus +namespace: biological_process +def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "mRNA export from cell nucleus" EXACT [] +synonym: "mRNA export out of nucleus" EXACT [] +synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "mRNA-nucleus export" EXACT [] +xref: Reactome:111439 +xref: Reactome:158484 +xref: Reactome:159046 +xref: Reactome:159050 +xref: Reactome:159234 +xref: Reactome:159236 +xref: Reactome:207621 +xref: Reactome:207624 +xref: Reactome:207627 +xref: Reactome:210824 +xref: Reactome:210828 +xref: Reactome:211322 +xref: Reactome:211328 +xref: Reactome:211910 +xref: Reactome:212042 +xref: Reactome:212086 +xref: Reactome:221674 +xref: Reactome:221844 +xref: Reactome:237384 +xref: Reactome:237388 +xref: Reactome:237791 +xref: Reactome:238454 +xref: Reactome:238480 +xref: Reactome:242316 +xref: Reactome:242319 +xref: Reactome:242322 +xref: Reactome:244148 +xref: Reactome:244152 +xref: Reactome:244445 +xref: Reactome:244451 +xref: Reactome:244865 +xref: Reactome:244964 +xref: Reactome:244994 +xref: Reactome:249756 +xref: Reactome:249876 +xref: Reactome:72202 +xref: Reactome:75096 +xref: Reactome:75097 +xref: Reactome:75098 +xref: Reactome:77587 +xref: Reactome:77594 +is_a: GO:0006405 ! RNA export from nucleus +is_a: GO:0051028 ! mRNA transport + +[Term] +id: GO:0006407 +name: rRNA export from nucleus +namespace: biological_process +def: "The directed movement of rRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "rRNA export from cell nucleus" EXACT [] +synonym: "rRNA export out of nucleus" EXACT [] +synonym: "rRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "rRNA-nucleus export" EXACT [] +is_a: GO:0006405 ! RNA export from nucleus +is_a: GO:0051029 ! rRNA transport + +[Term] +id: GO:0006408 +name: snRNA export from nucleus +namespace: biological_process +def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "snRNA export from cell nucleus" EXACT [] +synonym: "snRNA export out of nucleus" EXACT [] +synonym: "snRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "snRNA-nucleus export" EXACT [] +is_a: GO:0006405 ! RNA export from nucleus +is_a: GO:0051030 ! snRNA transport + +[Term] +id: GO:0006409 +name: tRNA export from nucleus +namespace: biological_process +def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "tRNA export from cell nucleus" EXACT [] +synonym: "tRNA export out of nucleus" EXACT [] +synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "tRNA-nucleus export" EXACT [] +is_a: GO:0006405 ! RNA export from nucleus +is_a: GO:0051031 ! tRNA transport + +[Term] +id: GO:0006410 +name: transcription, RNA-dependent +namespace: biological_process +def: "The synthesis of DNA on a template of RNA." [GOC:jl] +subset: gosubset_prok +synonym: "reverse transcription" EXACT [] +is_a: GO:0006350 ! transcription + +[Term] +id: GO:0006412 +name: translation +namespace: biological_process +alt_id: GO:0006416 +alt_id: GO:0006453 +alt_id: GO:0043037 +def: "The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:go_curators] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "protein anabolism" EXACT [] +synonym: "protein biosynthesis" EXACT [] +synonym: "protein formation" EXACT [] +synonym: "protein synthesis" EXACT [] +synonym: "protein translation" EXACT [] +is_a: GO:0034961 ! cellular biopolymer biosynthetic process +is_a: GO:0044267 ! cellular protein metabolic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0006413 +name: translational initiation +namespace: biological_process +alt_id: GO:0006440 +alt_id: GO:0006454 +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] +subset: gosubset_prok +synonym: "biopolymerisation" BROAD [] +synonym: "biopolymerization" BROAD [] +synonym: "protein synthesis initiation" BROAD [] +synonym: "translation initiation" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006414 +name: translational elongation +namespace: biological_process +alt_id: GO:0006442 +alt_id: GO:0006455 +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] +subset: gosubset_prok +synonym: "protein synthesis elongation" BROAD [] +synonym: "translation elongation" EXACT [] +xref: Reactome:156842 +xref: Reactome:211780 +xref: Reactome:221545 +xref: Reactome:230156 +xref: Reactome:238185 +xref: Reactome:244773 +xref: Reactome:249675 +xref: Reactome:252453 +xref: Reactome:255618 +xref: Reactome:259002 +xref: Reactome:262372 +xref: Reactome:265213 +xref: Reactome:268339 +xref: Reactome:274042 +xref: Reactome:280519 +xref: Reactome:282807 +xref: Reactome:286542 +xref: Reactome:288269 +xref: Reactome:289812 +xref: Reactome:290358 +xref: Reactome:291717 +is_a: GO:0034961 ! cellular biopolymer biosynthetic process +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006415 +name: translational termination +namespace: biological_process +alt_id: GO:0006443 +alt_id: GO:0006456 +def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] +subset: gosubset_prok +synonym: "protein synthesis termination" BROAD [] +synonym: "translation termination" EXACT [] +synonym: "translational complex disassembly" EXACT [] +xref: Reactome:141667 +xref: Reactome:141671 +xref: Reactome:141673 +xref: Reactome:141687 +xref: Reactome:141691 +xref: Reactome:141696 +xref: Reactome:141698 +xref: Reactome:208893 +xref: Reactome:208896 +xref: Reactome:210467 +xref: Reactome:211821 +xref: Reactome:218548 +xref: Reactome:218551 +xref: Reactome:220306 +xref: Reactome:221586 +xref: Reactome:227431 +xref: Reactome:227434 +xref: Reactome:228888 +xref: Reactome:230186 +xref: Reactome:235698 +xref: Reactome:235701 +xref: Reactome:236981 +xref: Reactome:238221 +xref: Reactome:242928 +xref: Reactome:242931 +xref: Reactome:243977 +xref: Reactome:244800 +xref: Reactome:248075 +xref: Reactome:248078 +xref: Reactome:248974 +xref: Reactome:249700 +xref: Reactome:251521 +xref: Reactome:251524 +xref: Reactome:251941 +xref: Reactome:252471 +xref: Reactome:255633 +xref: Reactome:257826 +xref: Reactome:257829 +xref: Reactome:258421 +xref: Reactome:259027 +xref: Reactome:261431 +xref: Reactome:261434 +xref: Reactome:261913 +xref: Reactome:262393 +xref: Reactome:264321 +xref: Reactome:264324 +xref: Reactome:264714 +xref: Reactome:265232 +xref: Reactome:267357 +xref: Reactome:267360 +xref: Reactome:267898 +xref: Reactome:268356 +xref: Reactome:272612 +xref: Reactome:272615 +xref: Reactome:273418 +xref: Reactome:274067 +xref: Reactome:278840 +xref: Reactome:278843 +xref: Reactome:279871 +xref: Reactome:280542 +xref: Reactome:282150 +xref: Reactome:282153 +xref: Reactome:282455 +xref: Reactome:282815 +xref: Reactome:285329 +xref: Reactome:285332 +xref: Reactome:285986 +xref: Reactome:286558 +xref: Reactome:287775 +xref: Reactome:287778 +xref: Reactome:287994 +xref: Reactome:288280 +xref: Reactome:289379 +xref: Reactome:289632 +xref: Reactome:289817 +xref: Reactome:72764 +is_a: GO:0043624 ! cellular protein complex disassembly +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006417 +name: regulation of translation +namespace: biological_process +alt_id: GO:0006445 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] +subset: gosubset_prok +synonym: "regulation of protein anabolism" EXACT [] +synonym: "regulation of protein biosynthesis" EXACT [] +synonym: "regulation of protein formation" EXACT [] +synonym: "regulation of protein synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0006412 ! translation + +[Term] +id: GO:0006418 +name: tRNA aminoacylation for protein translation +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] +subset: gosubset_prok +synonym: "tRNA charging" NARROW [] +xref: MetaCyc:TRNA-CHARGING-PWY +is_a: GO:0043039 ! tRNA aminoacylation +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006419 +name: alanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006420 +name: arginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006421 +name: asparaginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006422 +name: aspartyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006423 +name: cysteinyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006424 +name: glutamyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006425 +name: glutaminyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006426 +name: glycyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006427 +name: histidyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006428 +name: isoleucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006429 +name: leucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006430 +name: lysyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006431 +name: methionyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006432 +name: phenylalanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006433 +name: prolyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006434 +name: seryl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006435 +name: threonyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006436 +name: tryptophanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006437 +name: tyrosyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006438 +name: valyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] +subset: gosubset_prok +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006439 +name: aminoacyl-tRNA hydrolase reaction +namespace: biological_process +def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0004045 + +[Term] +id: GO:0006441 +name: binding to mRNA cap +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +consider: GO:0000339 + +[Term] +id: GO:0006446 +name: regulation of translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006417 ! regulation of translation +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006413 ! translational initiation + +[Term] +id: GO:0006447 +name: regulation of translational initiation by iron +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006446 ! regulation of translational initiation + +[Term] +id: GO:0006448 +name: regulation of translational elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translational elongation." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006417 ! regulation of translation +relationship: regulates GO:0006414 ! translational elongation + +[Term] +id: GO:0006449 +name: regulation of translational termination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006417 ! regulation of translation +is_a: GO:0043244 ! regulation of protein complex disassembly +relationship: regulates GO:0006415 ! translational termination + +[Term] +id: GO:0006450 +name: regulation of translational fidelity +namespace: biological_process +alt_id: GO:0000029 +def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "regulation of translational accuracy" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0006451 +name: translational readthrough +namespace: biological_process +def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg] +subset: gosubset_prok +synonym: "natural nonsense suppression" RELATED [] +is_a: GO:0006414 ! translational elongation +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0006452 +name: translational frameshifting +namespace: biological_process +def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425] +subset: gosubset_prok +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0006457 +name: protein folding +namespace: biological_process +def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "chaperone activity" RELATED [] +synonym: "chaperonin ATPase activity" RELATED [] +synonym: "co-chaperone activity" RELATED [] +synonym: "co-chaperonin activity" RELATED [] +synonym: "glycoprotein-specific chaperone activity" RELATED [] +synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] +synonym: "protein complex assembly, multichaperone pathway" RELATED [] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006458 +name: 'de novo' protein folding +namespace: biological_process +def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] +subset: gosubset_prok +synonym: "nascent chain protein folding" EXACT [] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0006459 +name: binding unfolded ER proteins +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +consider: GO:0005783 +consider: GO:0051082 + +[Term] +id: GO:0006460 +name: peptidyl-prolyl isomerase B reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +consider: GO:0003755 + +[Term] +id: GO:0006461 +name: protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] +subset: gosubset_prok +synonym: "chaperone activity" RELATED [] +synonym: "protein complex biosynthesis" EXACT [] +synonym: "protein complex formation" EXACT [] +is_a: GO:0065003 ! macromolecular complex assembly + +[Term] +id: GO:0006462 +name: protein complex assembly, multichaperone pathway +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. +is_obsolete: true +consider: GO:0006457 +consider: GO:0051131 + +[Term] +id: GO:0006463 +name: steroid hormone receptor complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, http://en.wikipedia.org/] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0006464 +name: protein modification process +namespace: biological_process +def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "process resulting in protein modification" RELATED [] +synonym: "protein tagging activity" RELATED [] +xref: Reactome:163841 +xref: Reactome:212091 +xref: Reactome:221849 +xref: Reactome:230417 +xref: Reactome:238459 +xref: Reactome:245000 +xref: Reactome:249885 +xref: Reactome:252603 +xref: Reactome:255790 +xref: Reactome:259184 +xref: Reactome:262540 +xref: Reactome:268494 +xref: Reactome:274221 +xref: Reactome:280690 +xref: Reactome:282898 +xref: Reactome:286709 +xref: Reactome:288370 +is_a: GO:0043412 ! biopolymer modification +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006465 +name: signal peptide processing +namespace: biological_process +def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] +subset: gosubset_prok +synonym: "leader peptide processing" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0006466 +name: protein disulfide-isomerase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it presents a molecular function. +synonym: "protein disulphide-isomerase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0003756 + +[Term] +id: GO:0006467 +name: protein thiol-disulfide exchange +namespace: biological_process +def: "Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond." [GOC:jsg] +subset: gosubset_prok +synonym: "disulphide bond biosynthesis" EXACT [] +synonym: "disulphide bond formation" EXACT [] +synonym: "protein thiol-disulphide exchange" EXACT [] +is_a: GO:0006457 ! protein folding +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0006468 +name: protein amino acid phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group on to a protein." [GOC:hb] +subset: gosubset_prok +xref: Reactome:210076 +xref: Reactome:219891 +xref: Reactome:236701 +xref: Reactome:73722 +is_a: GO:0016310 ! phosphorylation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0006469 +name: negative regulation of protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of protein kinase activity" EXACT [] +synonym: "down-regulation of protein kinase activity" EXACT [] +synonym: "downregulation of protein kinase activity" EXACT [] +synonym: "inhibition of protein kinase activity" NARROW [] +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0006470 +name: protein amino acid dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] +subset: gosubset_prok +is_a: GO:0016311 ! dephosphorylation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0006471 +name: protein amino acid ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] +subset: gosubset_prok +xref: RESID:AA0040 +xref: RESID:AA0168 +xref: RESID:AA0169 +xref: RESID:AA0231 +xref: RESID:AA0237 +xref: RESID:AA0295 +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0006473 +name: protein amino acid acetylation +namespace: biological_process +def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0006474 +name: N-terminal protein amino acid acetylation +namespace: biological_process +def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006473 ! protein amino acid acetylation +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0006475 +name: internal protein amino acid acetylation +namespace: biological_process +def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006473 ! protein amino acid acetylation + +[Term] +id: GO:0006476 +name: protein amino acid deacetylation +namespace: biological_process +def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0006477 +name: protein amino acid sulfation +namespace: biological_process +def: "The addition of a sulfate group as an ester to a protein amino acid." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "protein amino acid sulphation" EXACT [] +is_a: GO:0043687 ! post-translational protein modification +is_a: GO:0051923 ! sulfation + +[Term] +id: GO:0006478 +name: peptidyl-tyrosine sulfation +namespace: biological_process +def: "The posttranslational sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172] +subset: gosubset_prok +synonym: "peptidyl-tyrosine sulphation" EXACT [] +xref: RESID:AA0172 +is_a: GO:0006477 ! protein amino acid sulfation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0006479 +name: protein amino acid methylation +namespace: biological_process +def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008213 ! protein amino acid alkylation +is_a: GO:0043414 ! biopolymer methylation + +[Term] +id: GO:0006480 +name: N-terminal protein amino acid methylation +namespace: biological_process +def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0006481 +name: C-terminal protein amino acid methylation +namespace: biological_process +def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking + +[Term] +id: GO:0006482 +name: protein amino acid demethylation +namespace: biological_process +def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] +subset: gosubset_prok +is_a: GO:0008214 ! protein amino acid dealkylation + +[Term] +id: GO:0006483 +name: peptidyl-aspartic acid/asparagine hydroxylation +namespace: biological_process +def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai] +comment: This term was made obsolete because it is a redundant grouping term. +synonym: "aspartic acid/asparagine hydroxylation" EXACT [] +is_obsolete: true +consider: GO:0042264 +consider: GO:0042265 + +[Term] +id: GO:0006484 +name: protein cysteine-thiol oxidation +namespace: biological_process +def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025] +comment: This term was made obsolete because it represents a single activity. +is_obsolete: true +consider: GO:0003756 + +[Term] +id: GO:0006486 +name: protein amino acid glycosylation +namespace: biological_process +def: "The addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006464 ! protein modification process +is_a: GO:0043413 ! biopolymer glycosylation +relationship: part_of GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0006487 +name: protein amino acid N-linked glycosylation +namespace: biological_process +def: "The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine or the N1' atom peptidyl-tryptophan." [RESID:AA0151, RESID:AA0156, RESID:AA0327] +subset: gosubset_prok +synonym: "N-glycan biosynthesis" RELATED [] +synonym: "N-glycan metabolism" RELATED [] +xref: RESID:AA0151 +xref: RESID:AA0156 +xref: RESID:AA0327 +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0006488 +name: dolichol-linked oligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309 "Biochemical Pathways"] +subset: gosubset_prok +synonym: "dolichol-linked oligosaccharide anabolism" EXACT [] +synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT [] +synonym: "dolichol-linked oligosaccharide formation" EXACT [] +synonym: "dolichol-linked oligosaccharide synthesis" EXACT [] +synonym: "oligosaccharide-PP-dolichol assembly" EXACT [] +xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL+BIOSYNTHESIS +is_a: GO:0006487 ! protein amino acid N-linked glycosylation + +[Term] +id: GO:0006489 +name: dolichyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dolichyl diphosphate anabolism" EXACT [] +synonym: "dolichyl diphosphate biosynthesis" EXACT [] +synonym: "dolichyl diphosphate formation" EXACT [] +synonym: "dolichyl diphosphate synthesis" EXACT [] +xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL+BIOSYNTHESIS +is_a: GO:0019408 ! dolichol biosynthetic process +is_a: GO:0046465 ! dolichyl diphosphate metabolic process +relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process + +[Term] +id: GO:0006490 +name: oligosaccharide-lipid intermediate assembly +namespace: biological_process +def: "The cellular metabolic process by which an intermediate molecule of dolichol-P-man or dolicol-P-Glc is assembled to be used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0044255 ! cellular lipid metabolic process +is_a: GO:0051691 ! cellular oligosaccharide metabolic process +relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process + +[Term] +id: GO:0006491 +name: N-glycan processing +namespace: biological_process +alt_id: GO:0006492 +def: "The conversion of N-linked glycan structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] +subset: gosubset_prok +synonym: "N-glycan catabolism" RELATED [] +synonym: "N-glycan degradation" RELATED [] +synonym: "N-linked glycoprotein maturation" EXACT [] +is_a: GO:0006487 ! protein amino acid N-linked glycosylation + +[Term] +id: GO:0006493 +name: protein amino acid O-linked glycosylation +namespace: biological_process +def: "The formation of O-glycans by addition of glycosyl groups either to the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or to the phenol group of peptidyl-tyrosine." [ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] +subset: gosubset_prok +xref: RESID:AA0153 +xref: RESID:AA0154 +xref: RESID:AA0155 +xref: RESID:AA0157 +xref: RESID:AA0212 +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0006494 +name: protein amino acid terminal glycosylation +namespace: biological_process +def: "The glycosylation of a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0006495 +name: terminal O-glycosylation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg] +comment: This term was made obsolete because there is no evidence for the existence of this process. +is_obsolete: true + +[Term] +id: GO:0006496 +name: protein amino acid terminal N-glycosylation +namespace: biological_process +def: "The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg] +comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine. +subset: gosubset_prok +is_a: GO:0006487 ! protein amino acid N-linked glycosylation +is_a: GO:0006494 ! protein amino acid terminal glycosylation + +[Term] +id: GO:0006497 +name: protein amino acid lipidation +namespace: biological_process +alt_id: GO:0042050 +def: "The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein." [GOC:jl] +subset: gosubset_prok +synonym: "lipid:protein modification" EXACT [] +synonym: "protein lipidation" EXACT [] +xref: RESID:AA0059 +xref: RESID:AA0060 +xref: RESID:AA0077 +xref: RESID:AA0078 +xref: RESID:AA0079 +xref: RESID:AA0080 +xref: RESID:AA0102 +xref: RESID:AA0103 +xref: RESID:AA0104 +xref: RESID:AA0106 +xref: RESID:AA0107 +xref: RESID:AA0158 +xref: RESID:AA0159 +xref: RESID:AA0160 +xref: RESID:AA0161 +xref: RESID:AA0162 +xref: RESID:AA0163 +xref: RESID:AA0166 +xref: RESID:AA0223 +xref: RESID:AA0290 +xref: RESID:AA0307 +xref: RESID:AA0308 +xref: RESID:AA0309 +xref: RESID:AA0316 +is_a: GO:0006464 ! protein modification process +relationship: part_of GO:0042158 ! lipoprotein biosynthetic process + +[Term] +id: GO:0006498 +name: N-terminal protein lipidation +namespace: biological_process +def: "The covalent or non-covalent attachment of a lipid moiety to the amino terminus of a protein." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0006499 +name: N-terminal protein myristoylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a myristoyl moiety to the N-terminal amino acid residue of a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006498 ! N-terminal protein lipidation +is_a: GO:0018319 ! protein amino acid myristoylation + +[Term] +id: GO:0006500 +name: N-terminal protein palmitoylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006498 ! N-terminal protein lipidation +is_a: GO:0018318 ! protein amino acid palmitoylation + +[Term] +id: GO:0006501 +name: C-terminal protein lipidation +namespace: biological_process +def: "The covalent or non-covalent attachment of a lipid moiety to the carboxy terminus of a protein." [GOC:jl] +subset: gosubset_prok +xref: Reactome:163125 +xref: Reactome:211944 +xref: Reactome:221709 +xref: Reactome:230292 +xref: Reactome:238331 +xref: Reactome:244889 +xref: Reactome:249781 +xref: Reactome:252523 +xref: Reactome:255703 +xref: Reactome:259094 +xref: Reactome:262454 +xref: Reactome:268411 +xref: Reactome:274128 +xref: Reactome:280601 +xref: Reactome:282846 +xref: Reactome:286619 +xref: Reactome:288310 +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking + +[Term] +id: GO:0006502 +name: C-terminal protein prenylation +namespace: biological_process +def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl moiety to the carboxy terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl] +comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. +is_obsolete: true +replaced_by: GO:0018346 + +[Term] +id: GO:0006503 +name: C-terminal protein farnesylation +namespace: biological_process +def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl moiety to the carboxy terminus of a protein." [GOC:jl] +comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. +is_obsolete: true +replaced_by: GO:0018347 + +[Term] +id: GO:0006504 +name: C-terminal protein geranylgeranylation +namespace: biological_process +def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl moiety to the carboxy terminus of a protein." [GOC:jl] +comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. +is_obsolete: true +replaced_by: GO:0018348 + +[Term] +id: GO:0006505 +name: GPI anchor metabolic process +namespace: biological_process +alt_id: GO:0046472 +def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycosylphosphatidylinositol metabolic process" EXACT [] +synonym: "glycosylphosphatidylinositol metabolism" EXACT [] +synonym: "GPI anchor metabolism" EXACT [] +synonym: "GPI/GSI anchor metabolic process" BROAD [] +synonym: "GPI/GSI anchor metabolism" BROAD [] +is_a: GO:0030384 ! phosphoinositide metabolic process + +[Term] +id: GO:0006506 +name: GPI anchor biosynthetic process +namespace: biological_process +alt_id: GO:0015998 +def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] +subset: gosubset_prok +synonym: "glycosylphosphatidylinositol biosynthesis" EXACT [] +synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT [] +synonym: "GPI anchor anabolism" EXACT [] +synonym: "GPI anchor biosynthesis" EXACT [] +synonym: "GPI anchor formation" EXACT [] +synonym: "GPI anchor synthesis" EXACT [] +synonym: "GPI/GSI anchor biosynthesis" BROAD [] +synonym: "GPI/GSI anchor biosynthetic process" BROAD [] +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0006505 ! GPI anchor metabolic process +is_a: GO:0046489 ! phosphoinositide biosynthetic process + +[Term] +id: GO:0006507 +name: GPI anchor release +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006505 ! GPI anchor metabolic process + +[Term] +id: GO:0006508 +name: proteolysis +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein." [GOC:jsg] +subset: goslim_pir +subset: gosubset_prok +synonym: "peptidolysis" EXACT [] +xref: Reactome:159782 +xref: Reactome:211900 +xref: Reactome:221664 +xref: Reactome:230255 +xref: Reactome:238291 +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006509 +name: membrane protein ectodomain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] +subset: gosubset_prok +synonym: "membrane protein solubilization" RELATED [] +synonym: "receptor shedding" RELATED [] +is_a: GO:0033619 ! membrane protein proteolysis + +[Term] +id: GO:0006510 +name: ATP-dependent proteolysis +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl] +subset: gosubset_prok +synonym: "ATP-dependent peptidolysis" EXACT [] +is_a: GO:0006508 ! proteolysis + +[Term] +id: GO:0006511 +name: ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein." [GOC:go_curators] +synonym: "ubiquitin-dependent protein breakdown" EXACT [] +synonym: "ubiquitin-dependent protein catabolism" EXACT [] +synonym: "ubiquitin-dependent protein degradation" EXACT [] +synonym: "ubiquitin-dependent proteolysis" EXACT [] +is_a: GO:0019941 ! modification-dependent protein catabolic process + +[Term] +id: GO:0006512 +name: ubiquitin cycle +namespace: biological_process +def: "OBSOLETE. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093] +comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers. +is_obsolete: true + +[Term] +id: GO:0006513 +name: protein monoubiquitination +namespace: biological_process +def: "Addition of a single ubiquitin moiety to a protein." [GOC:ai] +synonym: "protein monoubiquitinylation" EXACT [] +synonym: "protein monoubiquitylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0006515 +name: misfolded or incompletely synthesized protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] +subset: gosubset_prok +synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] +synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] +synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] +synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0006516 +name: glycoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycoprotein breakdown" EXACT [] +synonym: "glycoprotein catabolism" EXACT [] +synonym: "glycoprotein degradation" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0006517 +name: protein deglycosylation +namespace: biological_process +def: "The removal of sugar residues from a glycosylated protein." [GOC:mah] +subset: gosubset_prok +synonym: "glycoprotein deglycosylation" EXACT [] +is_a: GO:0006464 ! protein modification process +is_a: GO:0006516 ! glycoprotein catabolic process + +[Term] +id: GO:0006518 +name: peptide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +subset: gosubset_prok +synonym: "peptide metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006519 +name: cellular amino acid and derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "amino acid and derivative metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044238 ! primary metabolic process + +[Term] +id: GO:0006520 +name: amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "amino acid metabolism" EXACT [] +is_a: GO:0006519 ! cellular amino acid and derivative metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006521 +name: regulation of amino acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of amino acid metabolism" EXACT [] +is_a: GO:0033238 ! regulation of amine metabolic process +relationship: regulates GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0006522 +name: alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "alanine metabolism" EXACT [] +xref: Reactome:211637 +xref: Reactome:221409 +xref: Reactome:230044 +xref: Reactome:238062 +xref: Reactome:244676 +xref: Reactome:249605 +xref: Reactome:252402 +xref: Reactome:255560 +xref: Reactome:258934 +xref: Reactome:262308 +xref: Reactome:265159 +xref: Reactome:268285 +xref: Reactome:273966 +xref: Reactome:280445 +xref: Reactome:282772 +xref: Reactome:286467 +xref: Reactome:290343 +xref: Reactome:70525 +is_a: GO:0009078 ! pyruvate family amino acid metabolic process + +[Term] +id: GO:0006523 +name: alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "alanine anabolism" EXACT [] +synonym: "alanine biosynthesis" EXACT [] +synonym: "alanine formation" EXACT [] +synonym: "alanine synthesis" EXACT [] +is_a: GO:0006522 ! alanine metabolic process +is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process + +[Term] +id: GO:0006524 +name: alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "alanine breakdown" EXACT [] +synonym: "alanine catabolism" EXACT [] +synonym: "alanine degradation" EXACT [] +is_a: GO:0006522 ! alanine metabolic process +is_a: GO:0009080 ! pyruvate family amino acid catabolic process + +[Term] +id: GO:0006525 +name: arginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators] +subset: gosubset_prok +synonym: "arginine metabolism" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006526 +name: arginine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "arginine anabolism" EXACT [] +synonym: "arginine biosynthesis" EXACT [] +synonym: "arginine formation" EXACT [] +synonym: "arginine synthesis" EXACT [] +xref: MetaCyc:ARGININE-SYN4-PWY +xref: MetaCyc:ARGSYN-PWY +xref: MetaCyc:ARGSYN-SHORT-PWY +xref: MetaCyc:ARGSYNBSUB-PWY +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006527 +name: arginine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators] +subset: gosubset_prok +synonym: "arginine breakdown" EXACT [] +synonym: "arginine catabolism" EXACT [] +synonym: "arginine degradation" EXACT [] +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006528 +name: asparagine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "asparagine metabolism" EXACT [] +xref: MetaCyc:ASPARAGINESYN-PWY +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006529 +name: asparagine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "asparagine anabolism" EXACT [] +synonym: "asparagine biosynthesis" EXACT [] +synonym: "asparagine formation" EXACT [] +synonym: "asparagine synthesis" EXACT [] +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0006530 +name: asparagine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "asparagine breakdown" EXACT [] +synonym: "asparagine catabolism" EXACT [] +synonym: "asparagine degradation" EXACT [] +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006531 +name: aspartate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aspartate metabolism" EXACT [] +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006532 +name: aspartate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aspartate anabolism" EXACT [] +synonym: "aspartate biosynthesis" EXACT [] +synonym: "aspartate formation" EXACT [] +synonym: "aspartate synthesis" EXACT [] +xref: MetaCyc:ASPBIO-PWY +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0006533 +name: aspartate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aspartate breakdown" EXACT [] +synonym: "aspartate catabolism" EXACT [] +synonym: "aspartate degradation" EXACT [] +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006534 +name: cysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "cysteine metabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0006535 +name: cysteine biosynthetic process from serine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] +subset: gosubset_prok +synonym: "cysteine anabolism from serine" EXACT [] +synonym: "cysteine formation from serine" EXACT [] +synonym: "cysteine synthesis from serine" EXACT [] +xref: MetaCyc:CYSTSYN-PWY +is_a: GO:0006563 ! L-serine metabolic process +is_a: GO:0019344 ! cysteine biosynthetic process + +[Term] +id: GO:0006536 +name: glutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate metabolism" EXACT [] +synonym: "glutamic acid metabolic process" EXACT [] +synonym: "glutamic acid metabolism" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006537 +name: glutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate anabolism" EXACT [] +synonym: "glutamate biosynthesis" EXACT [] +synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] +synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] +synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] +synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] +synonym: "glutamate formation" EXACT [] +synonym: "glutamate synthesis" EXACT [] +synonym: "glutamic acid biosynthesis" EXACT [] +synonym: "glutamic acid biosynthetic process" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006538 +name: glutamate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown" EXACT [] +synonym: "glutamate catabolism" EXACT [] +synonym: "glutamate degradation" EXACT [] +synonym: "glutamic acid catabolic process" EXACT [] +synonym: "glutamic acid catabolism" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006539 +name: glutamate catabolic process via 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown via 2-oxoglutarate" EXACT [] +synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT [] +synonym: "glutamate catabolism via 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT [] +synonym: "glutamate degradation via 2-oxoglutarate" EXACT [] +xref: MetaCyc:GLUTAMINE-DEG1-PWY +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0006540 +name: glutamate decarboxylation to succinate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438] +subset: gosubset_prok +synonym: "4-aminobutyrate shunt" EXACT [] +synonym: "GABA shunt" EXACT [] +synonym: "gamma-aminobutyrate shunt" EXACT [] +xref: MetaCyc:GLUDEG-I-PWY +xref: MetaCyc:PWY-4321 +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0006541 +name: glutamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "glutamine metabolism" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006542 +name: glutamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "glutamine anabolism" EXACT [] +synonym: "glutamine biosynthesis" EXACT [] +synonym: "glutamine formation" EXACT [] +synonym: "glutamine synthesis" EXACT [] +xref: MetaCyc:GLNSYN-PWY +xref: MetaCyc:GLUTAMINE-SYN2-PWY +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006543 +name: glutamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "glutamine breakdown" EXACT [] +synonym: "glutamine catabolism" EXACT [] +synonym: "glutamine degradation" EXACT [] +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006544 +name: glycine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0006545 +name: glycine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine anabolism" EXACT [] +synonym: "glycine biosynthesis" EXACT [] +synonym: "glycine formation" EXACT [] +synonym: "glycine synthesis" EXACT [] +xref: MetaCyc:GLYCINE-SYN2-PWY +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process + +[Term] +id: GO:0006546 +name: glycine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine breakdown" EXACT [] +synonym: "glycine catabolism" EXACT [] +synonym: "glycine degradation" EXACT [] +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process + +[Term] +id: GO:0006547 +name: histidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine metabolism" EXACT [] +is_a: GO:0009075 ! histidine family amino acid metabolic process + +[Term] +id: GO:0006548 +name: histidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine breakdown" EXACT [] +synonym: "histidine catabolism" EXACT [] +synonym: "histidine degradation" EXACT [] +xref: Reactome:211825 +xref: Reactome:221590 +xref: Reactome:230190 +xref: Reactome:238225 +xref: Reactome:249704 +xref: Reactome:259031 +xref: Reactome:274069 +xref: Reactome:280546 +xref: Reactome:286562 +xref: Reactome:70921 +is_a: GO:0006547 ! histidine metabolic process +is_a: GO:0009077 ! histidine family amino acid catabolic process + +[Term] +id: GO:0006549 +name: isoleucine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "isoleucine metabolism" EXACT [] +xref: MetaCyc:BRANCHED-CHAIN +is_a: GO:0009081 ! branched chain family amino acid metabolic process + +[Term] +id: GO:0006550 +name: isoleucine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "isoleucine breakdown" EXACT [] +synonym: "isoleucine catabolism" EXACT [] +synonym: "isoleucine degradation" EXACT [] +xref: MetaCyc:ILEU-DEG2-PWY +xref: MetaCyc:ILEUDEG-PWY +xref: Reactome:211644 +xref: Reactome:221416 +xref: Reactome:230051 +xref: Reactome:238069 +xref: Reactome:244681 +xref: Reactome:249609 +xref: Reactome:252407 +xref: Reactome:255566 +xref: Reactome:258939 +xref: Reactome:262314 +xref: Reactome:265164 +xref: Reactome:268290 +xref: Reactome:273971 +xref: Reactome:280450 +xref: Reactome:286472 +xref: Reactome:288240 +xref: Reactome:289788 +xref: Reactome:290365 +xref: Reactome:291691 +xref: Reactome:292390 +xref: Reactome:293668 +xref: Reactome:70845 +is_a: GO:0006549 ! isoleucine metabolic process +is_a: GO:0009083 ! branched chain family amino acid catabolic process + +[Term] +id: GO:0006551 +name: leucine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "leucine metabolism" EXACT [] +is_a: GO:0009081 ! branched chain family amino acid metabolic process + +[Term] +id: GO:0006552 +name: leucine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "leucine breakdown" EXACT [] +synonym: "leucine catabolism" EXACT [] +synonym: "leucine degradation" EXACT [] +xref: MetaCyc:LEU-DEG2-PWY +xref: MetaCyc:LEUDEG-PWY +xref: Reactome:211695 +xref: Reactome:221466 +xref: Reactome:230093 +xref: Reactome:238115 +xref: Reactome:244713 +xref: Reactome:249630 +xref: Reactome:252423 +xref: Reactome:255647 +xref: Reactome:258960 +xref: Reactome:262404 +xref: Reactome:265181 +xref: Reactome:268369 +xref: Reactome:273999 +xref: Reactome:280479 +xref: Reactome:286497 +xref: Reactome:288320 +xref: Reactome:289798 +xref: Reactome:290366 +xref: Reactome:291732 +xref: Reactome:292392 +xref: Reactome:293707 +xref: Reactome:70793 +is_a: GO:0006551 ! leucine metabolic process +is_a: GO:0009083 ! branched chain family amino acid catabolic process + +[Term] +id: GO:0006553 +name: lysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "lysine metabolism" EXACT [] +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006554 +name: lysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "lysine breakdown" EXACT [] +synonym: "lysine catabolism" EXACT [] +synonym: "lysine degradation" EXACT [] +xref: Reactome:211540 +xref: Reactome:221317 +xref: Reactome:229957 +xref: Reactome:237974 +xref: Reactome:244677 +xref: Reactome:249536 +xref: Reactome:252347 +xref: Reactome:255562 +xref: Reactome:258874 +xref: Reactome:262310 +xref: Reactome:265102 +xref: Reactome:268225 +xref: Reactome:273907 +xref: Reactome:280386 +xref: Reactome:286403 +xref: Reactome:288322 +xref: Reactome:289758 +xref: Reactome:291641 +xref: Reactome:293616 +xref: Reactome:71064 +is_a: GO:0006553 ! lysine metabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006555 +name: methionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methionine and threonine metabolic process" BROAD [] +synonym: "methionine and threonine metabolism" BROAD [] +synonym: "methionine metabolism" EXACT [] +xref: UM-BBD_pathwayID:met +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006556 +name: S-adenosylmethionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-adenosyl methionine biosynthesis" EXACT [] +synonym: "S-adenosyl methionine biosynthetic process" EXACT [] +synonym: "S-adenosylmethionine anabolism" EXACT [] +synonym: "S-adenosylmethionine biosynthesis" EXACT [] +synonym: "S-adenosylmethionine formation" EXACT [] +synonym: "S-adenosylmethionine synthesis" EXACT [] +synonym: "SAM biosynthetic process" EXACT [] +xref: MetaCyc:PWY-802 +xref: MetaCyc:SAM-PWY +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046500 ! S-adenosylmethionine metabolic process +relationship: part_of GO:0000097 ! sulfur amino acid biosynthetic process + +[Term] +id: GO:0006557 +name: S-adenosylmethioninamine biosynthetic process +namespace: biological_process +alt_id: GO:0006745 +def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] +subset: gosubset_prok +synonym: "S-adenosylmethioninamine anabolism" EXACT [] +synonym: "S-adenosylmethioninamine biosynthesis" EXACT [] +synonym: "S-adenosylmethioninamine formation" EXACT [] +synonym: "S-adenosylmethioninamine synthesis" EXACT [] +is_a: GO:0006743 ! ubiquinone metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process + +[Term] +id: GO:0006558 +name: L-phenylalanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-phenylalanine metabolism" EXACT [] +synonym: "phenylalanine metabolic process" BROAD [] +synonym: "phenylalanine metabolism" BROAD [] +is_a: GO:0009072 ! aromatic amino acid family metabolic process + +[Term] +id: GO:0006559 +name: L-phenylalanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-phenylalanine breakdown" EXACT [] +synonym: "L-phenylalanine catabolism" EXACT [] +synonym: "L-phenylalanine degradation" EXACT [] +synonym: "phenylalanine catabolic process" BROAD [] +synonym: "phenylalanine catabolism" BROAD [] +xref: Reactome:211591 +xref: Reactome:221367 +xref: Reactome:230005 +xref: Reactome:238024 +xref: Reactome:244640 +xref: Reactome:249576 +xref: Reactome:255536 +xref: Reactome:259020 +xref: Reactome:262285 +xref: Reactome:265139 +xref: Reactome:268263 +xref: Reactome:273947 +xref: Reactome:280426 +xref: Reactome:286441 +xref: Reactome:289775 +xref: Reactome:291745 +xref: Reactome:292352 +xref: Reactome:293648 +xref: Reactome:71182 +is_a: GO:0006558 ! L-phenylalanine metabolic process +is_a: GO:0009074 ! aromatic amino acid family catabolic process + +[Term] +id: GO:0006560 +name: proline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "proline metabolism" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006561 +name: proline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "proline anabolism" EXACT [] +synonym: "proline biosynthesis" EXACT [] +synonym: "proline formation" EXACT [] +synonym: "proline synthesis" EXACT [] +xref: MetaCyc:PROLINE-SYN2-PWY +xref: MetaCyc:PROSYN-PWY +xref: MetaCyc:PWY-3341 +xref: Reactome:211841 +xref: Reactome:221606 +xref: Reactome:230204 +xref: Reactome:238240 +xref: Reactome:244814 +xref: Reactome:249711 +xref: Reactome:252482 +xref: Reactome:255646 +xref: Reactome:259038 +xref: Reactome:262403 +xref: Reactome:265244 +xref: Reactome:268371 +xref: Reactome:274081 +xref: Reactome:280555 +xref: Reactome:286570 +xref: Reactome:288288 +xref: Reactome:289822 +xref: Reactome:290371 +xref: Reactome:291729 +xref: Reactome:292391 +xref: Reactome:293708 +xref: Reactome:70665 +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006562 +name: proline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "proline breakdown" EXACT [] +synonym: "proline catabolism" EXACT [] +synonym: "proline degradation" EXACT [] +xref: Reactome:211813 +xref: Reactome:221579 +xref: Reactome:230180 +xref: Reactome:238215 +xref: Reactome:244794 +xref: Reactome:249695 +xref: Reactome:252468 +xref: Reactome:255630 +xref: Reactome:259023 +xref: Reactome:262391 +xref: Reactome:265228 +xref: Reactome:268353 +xref: Reactome:274063 +xref: Reactome:280538 +xref: Reactome:286555 +xref: Reactome:288277 +xref: Reactome:289815 +xref: Reactome:290359 +xref: Reactome:291721 +xref: Reactome:292385 +xref: Reactome:293700 +xref: Reactome:70688 +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006563 +name: L-serine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "L-serine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0006564 +name: L-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "L-serine anabolism" EXACT [] +synonym: "L-serine biosynthesis" EXACT [] +synonym: "L-serine formation" EXACT [] +synonym: "L-serine synthesis" EXACT [] +xref: MetaCyc:SERGLYSII-PWY +xref: MetaCyc:SERSYN-PWY +is_a: GO:0006563 ! L-serine metabolic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process + +[Term] +id: GO:0006565 +name: L-serine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "L-serine breakdown" EXACT [] +synonym: "L-serine catabolism" EXACT [] +synonym: "L-serine degradation" EXACT [] +xref: MetaCyc:SERDEG-PWY +is_a: GO:0006563 ! L-serine metabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process + +[Term] +id: GO:0006566 +name: threonine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methionine and threonine metabolic process" BROAD [] +synonym: "methionine and threonine metabolism" BROAD [] +synonym: "threonine metabolism" EXACT [] +xref: UM-BBD_pathwayID:met +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006567 +name: threonine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "threonine breakdown" EXACT [] +synonym: "threonine catabolism" EXACT [] +synonym: "threonine degradation" EXACT [] +xref: MetaCyc:THREOCAT-PWY +xref: UM-BBD_pathwayID:met +is_a: GO:0006566 ! threonine metabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006568 +name: tryptophan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] +subset: gosubset_prok +synonym: "tryptophan metabolism" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0009072 ! aromatic amino acid family metabolic process + +[Term] +id: GO:0006569 +name: tryptophan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] +subset: gosubset_prok +synonym: "tryptophan breakdown" EXACT [] +synonym: "tryptophan catabolic process, using tryptophanase" NARROW [] +synonym: "tryptophan catabolism" EXACT [] +synonym: "tryptophan catabolism, using tryptophanase" NARROW [] +synonym: "tryptophan degradation" EXACT [] +xref: Reactome:211579 +xref: Reactome:221355 +xref: Reactome:229995 +xref: Reactome:238013 +xref: Reactome:244813 +xref: Reactome:249566 +xref: Reactome:252377 +xref: Reactome:255533 +xref: Reactome:258901 +xref: Reactome:265135 +xref: Reactome:268370 +xref: Reactome:286433 +xref: Reactome:71240 +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0009074 ! aromatic amino acid family catabolic process +is_a: GO:0046218 ! indolalkylamine catabolic process + +[Term] +id: GO:0006570 +name: tyrosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "tyrosine metabolism" EXACT [] +xref: UM-BBD_pathwayID:tyr +is_a: GO:0009072 ! aromatic amino acid family metabolic process + +[Term] +id: GO:0006571 +name: tyrosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm] +subset: gosubset_prok +synonym: "tyrosine anabolism" EXACT [] +synonym: "tyrosine biosynthesis" EXACT [] +synonym: "tyrosine formation" EXACT [] +synonym: "tyrosine synthesis" EXACT [] +xref: MetaCyc:PWY-3461 +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway + +[Term] +id: GO:0006572 +name: tyrosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "tyrosine breakdown" EXACT [] +synonym: "tyrosine catabolism" EXACT [] +synonym: "tyrosine degradation" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0009074 ! aromatic amino acid family catabolic process + +[Term] +id: GO:0006573 +name: valine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "valine metabolism" EXACT [] +is_a: GO:0009081 ! branched chain family amino acid metabolic process + +[Term] +id: GO:0006574 +name: valine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "valine breakdown" EXACT [] +synonym: "valine catabolism" EXACT [] +synonym: "valine degradation" EXACT [] +xref: MetaCyc:VAL-DEG2-PWY +xref: MetaCyc:VALDEG-PWY +xref: Reactome:211694 +xref: Reactome:221465 +xref: Reactome:230092 +xref: Reactome:238114 +xref: Reactome:244712 +xref: Reactome:249629 +xref: Reactome:252422 +xref: Reactome:255583 +xref: Reactome:258959 +xref: Reactome:262332 +xref: Reactome:265180 +xref: Reactome:268308 +xref: Reactome:273998 +xref: Reactome:280478 +xref: Reactome:286496 +xref: Reactome:288253 +xref: Reactome:289797 +xref: Reactome:290377 +xref: Reactome:291702 +xref: Reactome:292372 +xref: Reactome:293678 +xref: Reactome:70894 +is_a: GO:0006573 ! valine metabolic process +is_a: GO:0009083 ! branched chain family amino acid catabolic process + +[Term] +id: GO:0006575 +name: amino acid derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] +subset: gosubset_prok +synonym: "amino acid derivative metabolism" EXACT [] +is_a: GO:0006519 ! cellular amino acid and derivative metabolic process + +[Term] +id: GO:0006576 +name: biogenic amine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] +subset: gosubset_prok +synonym: "biogenic amine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0006577 +name: betaine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "betaine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006578 +name: betaine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "betaine anabolism" EXACT [] +synonym: "betaine biosynthesis" EXACT [] +synonym: "betaine formation" EXACT [] +synonym: "betaine synthesis" EXACT [] +is_a: GO:0006577 ! betaine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0006579 +name: betaine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "betaine breakdown" EXACT [] +synonym: "betaine catabolism" EXACT [] +synonym: "betaine degradation" EXACT [] +is_a: GO:0006577 ! betaine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0006580 +name: ethanolamine metabolic process +namespace: biological_process +alt_id: GO:0006645 +def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:jl, ISBN:01928006X] +subset: gosubset_prok +synonym: "ethanolamine metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0042439 ! ethanolamine and derivative metabolic process + +[Term] +id: GO:0006581 +name: acetylcholine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] +synonym: "acetylcholine breakdown" EXACT [] +synonym: "acetylcholine catabolism" EXACT [] +synonym: "acetylcholine degradation" EXACT [] +is_a: GO:0008291 ! acetylcholine metabolic process +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0006582 +name: melanin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators] +subset: gosubset_prok +synonym: "melanin metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0006583 +name: melanin biosynthetic process from tyrosine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] +subset: gosubset_prok +synonym: "melanin anabolism from tyrosine" EXACT [] +synonym: "melanin formation from tyrosine" EXACT [] +synonym: "melanin synthesis from tyrosine" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0006584 +name: catecholamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "catecholamine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0006585 +name: dopamine biosynthetic process from tyrosine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "dopamine anabolism from tyrosine" EXACT [] +synonym: "dopamine formation from tyrosine" EXACT [] +synonym: "dopamine synthesis from tyrosine" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0042416 ! dopamine biosynthetic process + +[Term] +id: GO:0006586 +name: indolalkylamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "indolalkylamine metabolism" EXACT [] +synonym: "indolamine metabolic process" BROAD [] +synonym: "indolamine metabolism" BROAD [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0042434 ! indole derivative metabolic process + +[Term] +id: GO:0006587 +name: serotonin biosynthetic process from tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "serotonin anabolism from tryptophan" EXACT [] +synonym: "serotonin formation from tryptophan" EXACT [] +synonym: "serotonin synthesis from tryptophan" EXACT [] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0042427 ! serotonin biosynthetic process + +[Term] +id: GO:0006588 +name: activation of tryptophan 5-monooxygenase activity +namespace: biological_process +def: "The process by which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb] +synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan + +[Term] +id: GO:0006589 +name: octopamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "octopamine anabolism" EXACT [] +synonym: "octopamine biosynthesis" EXACT [] +synonym: "octopamine formation" EXACT [] +synonym: "octopamine synthesis" EXACT [] +is_a: GO:0042136 ! neurotransmitter biosynthetic process +is_a: GO:0042401 ! biogenic amine biosynthetic process +is_a: GO:0046333 ! octopamine metabolic process + +[Term] +id: GO:0006590 +name: thyroid hormone generation +namespace: biological_process +def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] +comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. +is_a: GO:0042403 ! thyroid hormone metabolic process + +[Term] +id: GO:0006591 +name: ornithine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "ornithine metabolism" EXACT [] +xref: Reactome:211653 +xref: Reactome:221425 +xref: Reactome:230058 +xref: Reactome:238078 +xref: Reactome:244689 +xref: Reactome:249614 +xref: Reactome:252410 +xref: Reactome:255569 +xref: Reactome:258944 +xref: Reactome:262317 +xref: Reactome:265169 +xref: Reactome:268295 +xref: Reactome:273976 +xref: Reactome:280455 +xref: Reactome:282779 +xref: Reactome:286477 +xref: Reactome:288244 +xref: Reactome:289792 +xref: Reactome:290345 +xref: Reactome:291694 +xref: Reactome:292367 +xref: Reactome:293671 +xref: Reactome:70693 +is_a: GO:0019794 ! nonprotein amino acid metabolic process + +[Term] +id: GO:0006592 +name: ornithine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "ornithine anabolism" EXACT [] +synonym: "ornithine biosynthesis" EXACT [] +synonym: "ornithine formation" EXACT [] +synonym: "ornithine synthesis" EXACT [] +xref: MetaCyc:ORNSPNANA-PWY +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0019795 ! nonprotein amino acid biosynthetic process + +[Term] +id: GO:0006593 +name: ornithine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "ornithine breakdown" EXACT [] +synonym: "ornithine catabolism" EXACT [] +synonym: "ornithine degradation" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0019796 ! nonprotein amino acid catabolic process + +[Term] +id: GO:0006595 +name: polyamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyamine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process + +[Term] +id: GO:0006596 +name: polyamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyamine anabolism" EXACT [] +synonym: "polyamine biosynthesis" EXACT [] +synonym: "polyamine formation" EXACT [] +synonym: "polyamine synthesis" EXACT [] +xref: MetaCyc:POLYAMSYN-PWY +is_a: GO:0006595 ! polyamine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0006597 +name: spermine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "spermine anabolism" EXACT [] +synonym: "spermine biosynthesis" EXACT [] +synonym: "spermine formation" EXACT [] +synonym: "spermine synthesis" EXACT [] +xref: MetaCyc:ORNSPNANA-PWY +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0008215 ! spermine metabolic process + +[Term] +id: GO:0006598 +name: polyamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyamine breakdown" EXACT [] +synonym: "polyamine catabolism" EXACT [] +synonym: "polyamine degradation" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0006599 +name: phosphagen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphagen metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0006600 +name: creatine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "creatine metabolism" EXACT [] +xref: Reactome:211652 +xref: Reactome:221424 +xref: Reactome:230057 +xref: Reactome:238077 +xref: Reactome:252473 +xref: Reactome:255635 +xref: Reactome:258943 +xref: Reactome:262395 +xref: Reactome:268358 +xref: Reactome:274068 +xref: Reactome:280543 +xref: Reactome:71288 +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006601 +name: creatine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "creatine anabolism" EXACT [] +synonym: "creatine biosynthesis" EXACT [] +synonym: "creatine formation" EXACT [] +synonym: "creatine synthesis" EXACT [] +is_a: GO:0006600 ! creatine metabolic process +is_a: GO:0042396 ! phosphagen biosynthetic process + +[Term] +id: GO:0006602 +name: creatinine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "creatinine breakdown" EXACT [] +synonym: "creatinine catabolism" EXACT [] +synonym: "creatinine degradation" EXACT [] +is_a: GO:0042397 ! phosphagen catabolic process +is_a: GO:0046449 ! creatinine metabolic process + +[Term] +id: GO:0006603 +name: phosphocreatine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "phosphocreatine metabolism" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process + +[Term] +id: GO:0006604 +name: phosphoarginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "phosphoarginine metabolism" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process + +[Term] +id: GO:0006605 +name: protein targeting +namespace: biological_process +def: "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] +subset: gosubset_prok +synonym: "nascent polypeptide association" RELATED [] +synonym: "protein sorting along secretory pathway" NARROW [] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0006606 +name: protein import into nucleus +namespace: biological_process +def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] +synonym: "protein import into cell nucleus" EXACT [] +synonym: "protein nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus" EXACT [] +xref: Reactome:170796 +xref: Reactome:208668 +xref: Reactome:235532 +is_a: GO:0006605 ! protein targeting +is_a: GO:0017038 ! protein import +is_a: GO:0051170 ! nuclear import + +[Term] +id: GO:0006607 +name: NLS-bearing substrate import into nucleus +namespace: biological_process +def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] +synonym: "NLS-bearing substrate import into cell nucleus" EXACT [] +synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT [] +synonym: "NLS-bearing substrate-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0006608 +name: snRNP protein import into nucleus +namespace: biological_process +def: "The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] +synonym: "snRNP protein import into cell nucleus" EXACT [] +synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT [] +synonym: "snRNP protein-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0006609 +name: mRNA-binding (hnRNP) protein import into nucleus +namespace: biological_process +def: "The directed movement of a heterogeneous nuclear ribonucleoprotein complex from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT [] +synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT [] +synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0006610 +name: ribosomal protein import into nucleus +namespace: biological_process +def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] +synonym: "ribosomal protein import into cell nucleus" EXACT [] +synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT [] +synonym: "ribosomal protein-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0006611 +name: protein export from nucleus +namespace: biological_process +def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] +synonym: "protein export from cell nucleus" EXACT [] +synonym: "protein export out of nucleus" EXACT [] +synonym: "protein transport from nucleus to cytoplasm" EXACT [] +synonym: "protein-nucleus export" EXACT [] +xref: Reactome:170825 +xref: Reactome:208674 +xref: Reactome:218326 +xref: Reactome:227213 +xref: Reactome:235538 +xref: Reactome:242757 +is_a: GO:0006605 ! protein targeting +is_a: GO:0051168 ! nuclear export + +[Term] +id: GO:0006612 +name: protein targeting to membrane +namespace: biological_process +def: "The process of directing proteins towards a membrane using signals contained within the protein." [http://cancerweb.ncl.ac.uk/] +synonym: "protein membrane targeting" EXACT [] +synonym: "protein-membrane targeting" EXACT [] +is_a: GO:0006605 ! protein targeting + +[Term] +id: GO:0006613 +name: cotranslational protein targeting to membrane +namespace: biological_process +def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] +synonym: "cotranslational membrane targeting" EXACT [] +synonym: "cotranslational protein membrane targeting" EXACT [] +synonym: "cotranslational protein-membrane targeting" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane + +[Term] +id: GO:0006614 +name: SRP-dependent cotranslational protein targeting to membrane +namespace: biological_process +def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] +synonym: "ER translocation" BROAD [] +synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] +is_a: GO:0006613 ! cotranslational protein targeting to membrane +is_a: GO:0045047 ! protein targeting to ER + +[Term] +id: GO:0006615 +name: SRP-dependent cotranslational protein targeting to membrane, docking +namespace: biological_process +def: "The process by which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194] +synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT [] +is_a: GO:0022615 ! protein to membrane docking +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006616 +name: SRP-dependent cotranslational protein targeting to membrane, translocation +namespace: biological_process +def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363] +synonym: "ER translocation" BROAD [] +synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT [] +synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +is_a: GO:0065002 ! intracellular protein transmembrane transport +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006617 +name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition +namespace: biological_process +def: "The process by which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194] +synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006618 +name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing +namespace: biological_process +def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194] +synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT [] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006619 +name: SRP-independent cotranslational protein-membrane targeting +namespace: biological_process +def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515] +comment: This term was made obsolete because there is no evidence for the existence of this process. +synonym: "ER translocation" BROAD [] +synonym: "SRP-independent cotranslational membrane targeting" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006620 +name: posttranslational protein targeting to membrane +namespace: biological_process +def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363] +synonym: "posttranslational membrane targeting" EXACT [] +synonym: "posttranslational protein membrane targeting" EXACT [] +synonym: "posttranslational protein-membrane targeting" EXACT [] +synonym: "SRP-independent protein-membrane targeting" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane +is_a: GO:0045047 ! protein targeting to ER + +[Term] +id: GO:0006621 +name: protein retention in ER lumen +namespace: biological_process +def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] +synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb] +synonym: "protein-endoplasmic reticulum retention" EXACT [] +synonym: "protein-ER retention" EXACT [] +synonym: "retention of protein in endoplasmic reticulum" EXACT [] +synonym: "retention of protein in ER" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0006622 +name: protein targeting to lysosome +namespace: biological_process +def: "The process of directing proteins towards the lysosome using signals contained within the protein." [http://cancerweb.ncl.ac.uk/] +synonym: "protein-lysosome targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0007041 ! lysosomal transport + +[Term] +id: GO:0006623 +name: protein targeting to vacuole +namespace: biological_process +def: "The process of directing proteins towards the vacuole using signals contained within the protein." [http://cancerweb.ncl.ac.uk/] +synonym: "protein vacuolar targeting" EXACT [] +synonym: "protein-vacuolar targeting" EXACT [] +synonym: "protein-vacuole targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0006624 +name: vacuolar protein processing +namespace: biological_process +def: "The posttranslational modification of proteins in the vacuole, including proteolytic cleavage of precursors to form active enzymes." [GOC:mah] +synonym: "vacuolar protein maturation" EXACT [] +synonym: "vacuolar proteolysis" EXACT [] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0006625 +name: protein targeting to peroxisome +namespace: biological_process +def: "The process of directing proteins towards the peroxisome using signals contained within the protein." [GOC:ai] +synonym: "protein-peroxisome targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0043574 ! peroxisomal transport +relationship: part_of GO:0007031 ! peroxisome organization + +[Term] +id: GO:0006626 +name: protein targeting to mitochondrion +namespace: biological_process +def: "The process of directing proteins towards and into the mitochondrion, mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] +synonym: "mitochondrial protein import" RELATED [] +synonym: "mitochondrial translocation" RELATED [] +synonym: "protein targeting to mitochondria" EXACT [] +synonym: "protein-mitochondrial targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0006839 ! mitochondrial transport +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0006627 +name: mitochondrial protein processing during import +namespace: biological_process +def: "The cleavage of proteins, usually near the N terminus, during the process of import into the mitochondrion; several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769] +synonym: "mitochondrial processing" BROAD [] +is_a: GO:0034982 ! mitochondrial protein processing +relationship: part_of GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:0006628 +name: mitochondrial translocation +namespace: biological_process +def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576] +comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. +is_obsolete: true +consider: GO:0006626 + +[Term] +id: GO:0006629 +name: lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "lipid metabolism" EXACT [] +xref: Reactome:211949 +xref: Reactome:221714 +xref: Reactome:230304 +xref: Reactome:238336 +xref: Reactome:244894 +xref: Reactome:249787 +xref: Reactome:252529 +xref: Reactome:255713 +xref: Reactome:259099 +xref: Reactome:262464 +xref: Reactome:265294 +xref: Reactome:268417 +xref: Reactome:274140 +xref: Reactome:280613 +xref: Reactome:282852 +xref: Reactome:286671 +xref: Reactome:288319 +xref: Reactome:289875 +xref: Reactome:290413 +xref: Reactome:291758 +xref: Reactome:292446 +xref: Reactome:293732 +xref: Reactome:73923 +is_a: GO:0044238 ! primary metabolic process + +[Term] +id: GO:0006630 +name: lipid binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +consider: GO:0008289 + +[Term] +id: GO:0006631 +name: fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] +subset: gosubset_prok +synonym: "fatty acid metabolism" EXACT [] +xref: Reactome:207636 +xref: Reactome:217132 +xref: Reactome:242340 +xref: Reactome:247601 +xref: Reactome:267118 +xref: Reactome:272214 +xref: Reactome:278210 +xref: Reactome:76466 +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006633 +name: fatty acid biosynthetic process +namespace: biological_process +alt_id: GO:0000037 +def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fatty acid anabolism" EXACT [] +synonym: "fatty acid biosynthesis" EXACT [] +synonym: "fatty acid formation" EXACT [] +synonym: "fatty acid synthesis" EXACT [] +xref: MetaCyc:FASYN-INITIAL-PWY +xref: MetaCyc:PWY-4381 +xref: MetaCyc:PWY-5156 +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0006634 +name: hexadecanal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "hexadecanal anabolism" EXACT [] +synonym: "hexadecanal biosynthesis" EXACT [] +synonym: "hexadecanal formation" EXACT [] +synonym: "hexadecanal synthesis" EXACT [] +synonym: "palmitaldehyde biosynthesis" EXACT [] +synonym: "palmitaldehyde biosynthetic process" EXACT [] +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0046458 ! hexadecanal metabolic process + +[Term] +id: GO:0006635 +name: fatty acid beta-oxidation +namespace: biological_process +def: "The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: Reactome:109339 +xref: Reactome:109341 +xref: Reactome:109342 +xref: Reactome:109343 +xref: Reactome:109998 +xref: Reactome:207162 +xref: Reactome:209200 +xref: Reactome:210740 +xref: Reactome:210841 +xref: Reactome:210856 +xref: Reactome:211757 +xref: Reactome:212036 +xref: Reactome:216731 +xref: Reactome:218933 +xref: Reactome:220631 +xref: Reactome:220691 +xref: Reactome:220706 +xref: Reactome:221524 +xref: Reactome:221800 +xref: Reactome:227736 +xref: Reactome:229307 +xref: Reactome:229381 +xref: Reactome:229389 +xref: Reactome:230202 +xref: Reactome:230396 +xref: Reactome:234264 +xref: Reactome:235965 +xref: Reactome:237300 +xref: Reactome:237395 +xref: Reactome:237408 +xref: Reactome:238167 +xref: Reactome:238413 +xref: Reactome:242015 +xref: Reactome:243139 +xref: Reactome:244757 +xref: Reactome:244960 +xref: Reactome:247389 +xref: Reactome:249130 +xref: Reactome:249663 +xref: Reactome:249839 +xref: Reactome:251206 +xref: Reactome:252064 +xref: Reactome:252445 +xref: Reactome:252572 +xref: Reactome:255267 +xref: Reactome:255679 +xref: Reactome:255782 +xref: Reactome:258563 +xref: Reactome:259074 +xref: Reactome:259175 +xref: Reactome:265366 +xref: Reactome:267507 +xref: Reactome:267955 +xref: Reactome:268368 +xref: Reactome:268473 +xref: Reactome:273504 +xref: Reactome:274108 +xref: Reactome:274213 +xref: Reactome:279976 +xref: Reactome:280581 +xref: Reactome:280682 +xref: Reactome:286710 +xref: Reactome:289872 +xref: Reactome:291790 +xref: Reactome:293500 +xref: Reactome:293508 +xref: Reactome:293509 +xref: Reactome:293718 +xref: Reactome:293767 +xref: Reactome:77288 +xref: Reactome:77289 +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0006636 +name: unsaturated fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782] +subset: gosubset_prok +synonym: "fatty acid desaturation" RELATED [] +synonym: "unsaturated fatty acid anabolism" EXACT [] +synonym: "unsaturated fatty acid biosynthesis" EXACT [] +synonym: "unsaturated fatty acid formation" EXACT [] +synonym: "unsaturated fatty acid synthesis" EXACT [] +xref: MetaCyc:PWY-762 +xref: MetaCyc:PWY-782 +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0033559 ! unsaturated fatty acid metabolic process + +[Term] +id: GO:0006637 +name: acyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "acyl-CoA metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0006638 +name: neutral lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] +subset: gosubset_prok +synonym: "neutral lipid metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006639 +name: acylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "acylglycerol metabolism" EXACT [] +synonym: "glyceride metabolic process" EXACT [] +synonym: "glyceride metabolism" EXACT [] +is_a: GO:0006638 ! neutral lipid metabolic process +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0006640 +name: monoacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "monoacylglycerol anabolism" EXACT [] +synonym: "monoacylglycerol biosynthesis" EXACT [] +synonym: "monoacylglycerol formation" EXACT [] +synonym: "monoacylglycerol synthesis" EXACT [] +synonym: "monoglyceride biosynthesis" EXACT [] +synonym: "monoglyceride biosynthetic process" EXACT [] +is_a: GO:0046462 ! monoacylglycerol metabolic process +is_a: GO:0046463 ! acylglycerol biosynthetic process + +[Term] +id: GO:0006641 +name: triacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving triacylglycerol, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "triacylglycerol metabolism" EXACT [] +synonym: "triglyceride metabolic process" EXACT [] +synonym: "triglyceride metabolism" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0006642 +name: triacylglycerol mobilization +namespace: biological_process +def: "The release of triacylglycerols, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] +subset: gosubset_prok +synonym: "triglyceride mobilization" EXACT [] +is_a: GO:0006641 ! triacylglycerol metabolic process + +[Term] +id: GO:0006643 +name: membrane lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] +subset: gosubset_prok +synonym: "membrane lipid metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006644 +name: phospholipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phospholipid metabolism" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process + +[Term] +id: GO:0006646 +name: phosphatidylethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylethanolamine anabolism" EXACT [] +synonym: "phosphatidylethanolamine biosynthesis" EXACT [] +synonym: "phosphatidylethanolamine formation" EXACT [] +synonym: "phosphatidylethanolamine synthesis" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0046335 ! ethanolamine biosynthetic process +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0006647 +name: phosphatidyl-N-monomethylethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai] +subset: gosubset_prok +synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT [] +synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT [] +synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT [] +synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT [] +synonym: "PMME biosynthesis" EXACT [] +synonym: "PMME biosynthetic process" EXACT [] +is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process +is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process + +[Term] +id: GO:0006648 +name: dihydrosphingosine-1-P pathway +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process + +[Term] +id: GO:0006649 +name: phospholipid transfer to membrane +namespace: biological_process +def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0015914 ! phospholipid transport + +[Term] +id: GO:0006650 +name: glycerophospholipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerophospholipid metabolism" EXACT [] +synonym: "phosphoglyceride metabolic process" EXACT [] +synonym: "phosphoglyceride metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:0006651 +name: diacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "diacylglycerol anabolism" EXACT [] +synonym: "diacylglycerol biosynthesis" EXACT [] +synonym: "diacylglycerol formation" EXACT [] +synonym: "diacylglycerol synthesis" EXACT [] +is_a: GO:0046339 ! diacylglycerol metabolic process +is_a: GO:0046463 ! acylglycerol biosynthetic process + +[Term] +id: GO:0006652 +name: alpha-glycerophosphate pathway +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0006653 +name: lecithin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lecithin, any 3-sn-phosphatidylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lecithin metabolism" EXACT [] +is_a: GO:0046470 ! phosphatidylcholine metabolic process + +[Term] +id: GO:0006654 +name: phosphatidic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidic acid anabolism" EXACT [] +synonym: "phosphatidic acid biosynthesis" EXACT [] +synonym: "phosphatidic acid formation" EXACT [] +synonym: "phosphatidic acid synthesis" EXACT [] +xref: MetaCyc:PHOSACIDSYN-PWY +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046473 ! phosphatidic acid metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006655 +name: phosphatidylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylglycerol anabolism" EXACT [] +synonym: "phosphatidylglycerol biosynthesis" EXACT [] +synonym: "phosphatidylglycerol formation" EXACT [] +synonym: "phosphatidylglycerol synthesis" EXACT [] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006656 +name: phosphatidylcholine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylcholine anabolism" EXACT [] +synonym: "phosphatidylcholine biosynthesis" EXACT [] +synonym: "phosphatidylcholine formation" EXACT [] +synonym: "phosphatidylcholine synthesis" EXACT [] +is_a: GO:0046470 ! phosphatidylcholine metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006657 +name: CDP-choline pathway +namespace: biological_process +def: "The formation of phosphatidylcholines via the combination of CDP-choline with diacylglycerol." [ISBN:0471331309 "Biochemical Pathways"] +subset: gosubset_prok +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0006658 +name: phosphatidylserine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylserine metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0006659 +name: phosphatidylserine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylserine anabolism" EXACT [] +synonym: "phosphatidylserine biosynthesis" EXACT [] +synonym: "phosphatidylserine formation" EXACT [] +synonym: "phosphatidylserine synthesis" EXACT [] +is_a: GO:0006658 ! phosphatidylserine metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006660 +name: phosphatidylserine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylserine breakdown" EXACT [] +synonym: "phosphatidylserine catabolism" EXACT [] +synonym: "phosphatidylserine degradation" EXACT [] +is_a: GO:0006658 ! phosphatidylserine metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0006661 +name: phosphatidylinositol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylinositol anabolism" EXACT [] +synonym: "phosphatidylinositol biosynthesis" EXACT [] +synonym: "phosphatidylinositol formation" EXACT [] +synonym: "phosphatidylinositol synthesis" EXACT [] +synonym: "PtdIns biosynthesis" EXACT [] +synonym: "PtdIns biosynthetic process" EXACT [] +is_a: GO:0046488 ! phosphatidylinositol metabolic process +is_a: GO:0046489 ! phosphoinositide biosynthetic process + +[Term] +id: GO:0006662 +name: glycerol ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "glycerol ether metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006663 +name: platelet activating factor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] +synonym: "PAF biosynthesis" EXACT [] +synonym: "PAF biosynthetic process" EXACT [] +synonym: "platelet activating factor anabolism" EXACT [] +synonym: "platelet activating factor biosynthesis" EXACT [] +synonym: "platelet activating factor formation" EXACT [] +synonym: "platelet activating factor synthesis" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0046469 ! platelet activating factor metabolic process + +[Term] +id: GO:0006664 +name: glycolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [ISBN:0198547684] +subset: gosubset_prok +synonym: "glycolipid metabolism" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process + +[Term] +id: GO:0006665 +name: sphingolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingolipid metabolism" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process + +[Term] +id: GO:0006666 +name: 3-keto-sphinganine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai] +subset: gosubset_prok +synonym: "3-keto-dihydrosphingosine metabolic process" EXACT [] +synonym: "3-keto-dihydrosphingosine metabolism" EXACT [] +synonym: "3-keto-sphinganine metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006667 +name: sphinganine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18] +subset: gosubset_prok +synonym: "dihydrosphingosine metabolic process" EXACT [] +synonym: "dihydrosphingosine metabolism" EXACT [] +synonym: "sphinganine metabolism" EXACT [] +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006668 +name: sphinganine-1-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +subset: gosubset_prok +synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT [] +synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT [] +synonym: "sphinganine-1-phosphate metabolism" EXACT [] +is_a: GO:0006667 ! sphinganine metabolic process + +[Term] +id: GO:0006669 +name: sphinganine-1-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +subset: gosubset_prok +synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT [] +synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT [] +synonym: "sphinganine-1-phosphate anabolism" EXACT [] +synonym: "sphinganine-1-phosphate biosynthesis" EXACT [] +synonym: "sphinganine-1-phosphate formation" EXACT [] +synonym: "sphinganine-1-phosphate synthesis" EXACT [] +is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process +is_a: GO:0046511 ! sphinganine biosynthetic process + +[Term] +id: GO:0006670 +name: sphingosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "(4E)-sphing-4-enine metabolic process" EXACT [] +synonym: "(4E)-sphing-4-enine metabolism" EXACT [] +synonym: "sphing-4-enine metabolic process" EXACT [] +synonym: "sphing-4-enine metabolism" EXACT [] +synonym: "sphingosine metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006671 +name: phytosphingosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-amino-1,3,4-octadecanetriol, a constituent of many plant sphingolipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phytosphingosine metabolism" EXACT [] +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006672 +name: ceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684] +subset: gosubset_prok +synonym: "ceramide metabolism" EXACT [] +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006673 +name: inositolphosphoceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inositolphosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html] +subset: gosubset_prok +synonym: "inositolphosphoceramide metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006672 ! ceramide metabolic process + +[Term] +id: GO:0006674 +name: inositol phosphorylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inositol phosphorylceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety. The phosphate-containing moiety is the trivalent -P(O)= and the ceramide moiety of this lipid consists of phytosphingosine and a hydroxy C26 fatty acid." [http://www.cyberlipid.org/] +subset: gosubset_prok +synonym: "inositol phosphorylceramide metabolism" EXACT [] +is_a: GO:0006673 ! inositolphosphoceramide metabolic process + +[Term] +id: GO:0006675 +name: mannose inositol phosphoceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannose inositol phosphoceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] +subset: gosubset_prok +synonym: "mannose inositol phosphoceramide metabolism" EXACT [] +synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT [] +synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] +synonym: "MIPC metabolic process" EXACT [] +synonym: "MIPC metabolism" EXACT [] +is_a: GO:0006673 ! inositolphosphoceramide metabolic process + +[Term] +id: GO:0006676 +name: mannosyl diphosphorylinositol ceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] +subset: gosubset_prok +synonym: "M(IP)2C metabolic process" EXACT [] +synonym: "M(IP)2C metabolism" EXACT [] +synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT [] +is_a: GO:0006673 ! inositolphosphoceramide metabolic process + +[Term] +id: GO:0006677 +name: glycosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycosylceramide metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0006672 ! ceramide metabolic process + +[Term] +id: GO:0006678 +name: glucosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucosylceramide metabolism" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process + +[Term] +id: GO:0006679 +name: glucosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "glucosylceramide anabolism" EXACT [] +synonym: "glucosylceramide biosynthesis" EXACT [] +synonym: "glucosylceramide formation" EXACT [] +synonym: "glucosylceramide synthesis" EXACT [] +is_a: GO:0006678 ! glucosylceramide metabolic process +is_a: GO:0046476 ! glycosylceramide biosynthetic process + +[Term] +id: GO:0006680 +name: glucosylceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "glucosylceramide breakdown" EXACT [] +synonym: "glucosylceramide catabolism" EXACT [] +synonym: "glucosylceramide degradation" EXACT [] +is_a: GO:0006678 ! glucosylceramide metabolic process +is_a: GO:0046477 ! glycosylceramide catabolic process + +[Term] +id: GO:0006681 +name: galactosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "galactosylceramide metabolism" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process +is_a: GO:0019374 ! galactolipid metabolic process + +[Term] +id: GO:0006682 +name: galactosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "galactosylceramide anabolism" EXACT [] +synonym: "galactosylceramide biosynthesis" EXACT [] +synonym: "galactosylceramide formation" EXACT [] +synonym: "galactosylceramide synthesis" EXACT [] +is_a: GO:0006681 ! galactosylceramide metabolic process +is_a: GO:0019375 ! galactolipid biosynthetic process +is_a: GO:0046476 ! glycosylceramide biosynthetic process + +[Term] +id: GO:0006683 +name: galactosylceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "galactosylceramide breakdown" EXACT [] +synonym: "galactosylceramide catabolism" EXACT [] +synonym: "galactosylceramide degradation" EXACT [] +is_a: GO:0006681 ! galactosylceramide metabolic process +is_a: GO:0019376 ! galactolipid catabolic process +is_a: GO:0046477 ! glycosylceramide catabolic process + +[Term] +id: GO:0006684 +name: sphingomyelin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingomyelin metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0006685 +name: sphingomyelin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingomyelin breakdown" EXACT [] +synonym: "sphingomyelin catabolism" EXACT [] +synonym: "sphingomyelin degradation" EXACT [] +is_a: GO:0006684 ! sphingomyelin metabolic process +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0006686 +name: sphingomyelin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingomyelin anabolism" EXACT [] +synonym: "sphingomyelin biosynthesis" EXACT [] +synonym: "sphingomyelin formation" EXACT [] +synonym: "sphingomyelin synthesis" EXACT [] +is_a: GO:0006684 ! sphingomyelin metabolic process +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0006687 +name: glycosphingolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] +subset: gosubset_prok +synonym: "glycosphingolipid metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0006688 +name: glycosphingolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycosphingolipid anabolism" EXACT [] +synonym: "glycosphingolipid biosynthesis" EXACT [] +synonym: "glycosphingolipid formation" EXACT [] +synonym: "glycosphingolipid synthesis" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0006689 +name: ganglioside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684] +subset: gosubset_prok +synonym: "ganglioside breakdown" EXACT [] +synonym: "ganglioside catabolism" EXACT [] +synonym: "ganglioside degradation" EXACT [] +is_a: GO:0001573 ! ganglioside metabolic process +is_a: GO:0046479 ! glycosphingolipid catabolic process + +[Term] +id: GO:0006690 +name: icosanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma] +subset: gosubset_prok +synonym: "eicosanoid metabolic process" EXACT [] +synonym: "eicosanoid metabolism" EXACT [] +synonym: "icosanoid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0006691 +name: leukotriene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma] +subset: gosubset_prok +synonym: "leukotriene metabolism" EXACT [] +is_a: GO:0006690 ! icosanoid metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0006692 +name: prostanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "prostanoid metabolism" EXACT [] +is_a: GO:0006690 ! icosanoid metabolic process + +[Term] +id: GO:0006693 +name: prostaglandin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "prostaglandin metabolism" EXACT [] +is_a: GO:0006692 ! prostanoid metabolic process + +[Term] +id: GO:0006694 +name: steroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] +subset: gosubset_prok +synonym: "steroid anabolism" EXACT [] +synonym: "steroid biosynthesis" EXACT [] +synonym: "steroid formation" EXACT [] +synonym: "steroid synthesis" EXACT [] +synonym: "steroidogenesis" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0006695 +name: cholesterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] +synonym: "cholesterol anabolism" EXACT [] +synonym: "cholesterol biosynthesis" EXACT [] +synonym: "cholesterol formation" EXACT [] +synonym: "cholesterol synthesis" EXACT [] +xref: Reactome:191273 +xref: Reactome:211620 +xref: Reactome:221394 +xref: Reactome:230028 +xref: Reactome:238046 +xref: Reactome:244661 +xref: Reactome:249645 +xref: Reactome:252392 +xref: Reactome:255548 +xref: Reactome:258923 +xref: Reactome:262347 +xref: Reactome:265194 +xref: Reactome:268274 +xref: Reactome:274015 +xref: Reactome:280493 +xref: Reactome:286456 +xref: Reactome:289781 +xref: Reactome:290352 +xref: Reactome:291728 +xref: Reactome:293706 +is_a: GO:0008203 ! cholesterol metabolic process +is_a: GO:0016126 ! sterol biosynthetic process + +[Term] +id: GO:0006696 +name: ergosterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ergosterol anabolism" EXACT [] +synonym: "ergosterol biosynthesis" EXACT [] +synonym: "ergosterol formation" EXACT [] +synonym: "ergosterol synthesis" EXACT [] +is_a: GO:0008204 ! ergosterol metabolic process +is_a: GO:0016126 ! sterol biosynthetic process + +[Term] +id: GO:0006697 +name: ecdysone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ecdysone anabolism" EXACT [] +synonym: "ecdysone biosynthesis" EXACT [] +synonym: "ecdysone formation" EXACT [] +synonym: "ecdysone synthesis" EXACT [] +is_a: GO:0008205 ! ecdysone metabolic process +is_a: GO:0016126 ! sterol biosynthetic process +is_a: GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0006698 +name: ecdysone modification +namespace: biological_process +def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl] +comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process. +is_obsolete: true +replaced_by: GO:0004501 + +[Term] +id: GO:0006699 +name: bile acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +synonym: "bile acid anabolism" EXACT [] +synonym: "bile acid biosynthesis" EXACT [] +synonym: "bile acid formation" EXACT [] +synonym: "bile acid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0006700 +name: C21-steroid hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] +synonym: "C21-steroid hormone anabolism" EXACT [] +synonym: "C21-steroid hormone biosynthesis" EXACT [] +synonym: "C21-steroid hormone formation" EXACT [] +synonym: "C21-steroid hormone synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006701 +name: progesterone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] +synonym: "progesterone anabolism" EXACT [] +synonym: "progesterone biosynthesis" EXACT [] +synonym: "progesterone formation" EXACT [] +synonym: "progesterone synthesis" EXACT [] +is_a: GO:0006700 ! C21-steroid hormone biosynthetic process +is_a: GO:0042448 ! progesterone metabolic process + +[Term] +id: GO:0006702 +name: androgen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "androgen anabolism" EXACT [] +synonym: "androgen biosynthesis" EXACT [] +synonym: "androgen formation" EXACT [] +synonym: "androgen synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008209 ! androgen metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006703 +name: estrogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "estrogen anabolism" EXACT [] +synonym: "estrogen biosynthesis" EXACT [] +synonym: "estrogen formation" EXACT [] +synonym: "estrogen synthesis" EXACT [] +synonym: "oestrogen biosynthesis" EXACT [] +synonym: "oestrogen biosynthetic process" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008210 ! estrogen metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006704 +name: glucocorticoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "glucocorticoid anabolism" EXACT [] +synonym: "glucocorticoid biosynthesis" EXACT [] +synonym: "glucocorticoid formation" EXACT [] +synonym: "glucocorticoid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008211 ! glucocorticoid metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006705 +name: mineralocorticoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "mineralocorticoid anabolism" EXACT [] +synonym: "mineralocorticoid biosynthesis" EXACT [] +synonym: "mineralocorticoid formation" EXACT [] +synonym: "mineralocorticoid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008212 ! mineralocorticoid metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006706 +name: steroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] +subset: gosubset_prok +synonym: "steroid breakdown" EXACT [] +synonym: "steroid catabolism" EXACT [] +synonym: "steroid degradation" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0006707 +name: cholesterol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] +synonym: "cholesterol breakdown" EXACT [] +synonym: "cholesterol catabolism" EXACT [] +synonym: "cholesterol degradation" EXACT [] +is_a: GO:0008203 ! cholesterol metabolic process +is_a: GO:0016127 ! sterol catabolic process + +[Term] +id: GO:0006708 +name: ecdysone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ecdysone breakdown" EXACT [] +synonym: "ecdysone catabolism" EXACT [] +synonym: "ecdysone degradation" EXACT [] +is_a: GO:0008205 ! ecdysone metabolic process +is_a: GO:0016127 ! sterol catabolic process +is_a: GO:0046344 ! ecdysteroid catabolic process + +[Term] +id: GO:0006709 +name: progesterone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] +synonym: "progesterone breakdown" EXACT [] +synonym: "progesterone catabolism" EXACT [] +synonym: "progesterone degradation" EXACT [] +is_a: GO:0008208 ! C21-steroid hormone catabolic process +is_a: GO:0042448 ! progesterone metabolic process + +[Term] +id: GO:0006710 +name: androgen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "androgen breakdown" EXACT [] +synonym: "androgen catabolism" EXACT [] +synonym: "androgen degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008209 ! androgen metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006711 +name: estrogen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "estrogen breakdown" EXACT [] +synonym: "estrogen catabolism" EXACT [] +synonym: "estrogen degradation" EXACT [] +synonym: "oestrogen catabolic process" EXACT [] +synonym: "oestrogen catabolism" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008210 ! estrogen metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006712 +name: mineralocorticoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "mineralocorticoid breakdown" EXACT [] +synonym: "mineralocorticoid catabolism" EXACT [] +synonym: "mineralocorticoid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008212 ! mineralocorticoid metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006713 +name: glucocorticoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "glucocorticoid breakdown" EXACT [] +synonym: "glucocorticoid catabolism" EXACT [] +synonym: "glucocorticoid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008211 ! glucocorticoid metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006714 +name: sesquiterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] +subset: gosubset_prok +synonym: "sesquiterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:0006715 +name: farnesol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684] +subset: gosubset_prok +synonym: "farnesol anabolism" EXACT [] +synonym: "farnesol biosynthesis" EXACT [] +synonym: "farnesol formation" EXACT [] +synonym: "farnesol synthesis" EXACT [] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0016487 ! farnesol metabolic process +is_a: GO:0034309 ! monohydric alcohol biosynthetic process + +[Term] +id: GO:0006716 +name: juvenile hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +synonym: "juvenile hormone metabolism" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0006717 +name: juvenile hormone binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +consider: GO:0005500 + +[Term] +id: GO:0006718 +name: juvenile hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +synonym: "juvenile hormone anabolism" EXACT [] +synonym: "juvenile hormone biosynthesis" EXACT [] +synonym: "juvenile hormone formation" EXACT [] +synonym: "juvenile hormone synthesis" EXACT [] +is_a: GO:0006716 ! juvenile hormone metabolic process +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006719 +name: juvenile hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +synonym: "juvenile hormone breakdown" EXACT [] +synonym: "juvenile hormone catabolism" EXACT [] +synonym: "juvenile hormone degradation" EXACT [] +is_a: GO:0006716 ! juvenile hormone metabolic process +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006720 +name: isoprenoid metabolic process +namespace: biological_process +alt_id: GO:0016096 +def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] +subset: gosubset_prok +synonym: "isoprenoid metabolism" EXACT [] +synonym: "polyisoprenoid metabolic process" NARROW [] +synonym: "polyisoprenoid metabolism" NARROW [] +synonym: "polyterpene metabolic process" NARROW [] +synonym: "polyterpene metabolism" NARROW [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006721 +name: terpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "terpenoid metabolism" EXACT [] +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0006722 +name: triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684] +subset: gosubset_prok +synonym: "triterpene metabolic process" NARROW [] +synonym: "triterpene metabolism" NARROW [] +synonym: "triterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0006723 +name: cuticle hydrocarbon biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] +synonym: "cuticle hydrocarbon anabolism" EXACT [] +synonym: "cuticle hydrocarbon biosynthesis" EXACT [] +synonym: "cuticle hydrocarbon formation" EXACT [] +synonym: "cuticle hydrocarbon synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0006725 +name: cellular aromatic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "aromatic compound metabolism" EXACT [] +synonym: "aromatic hydrocarbon metabolic process" NARROW [] +synonym: "aromatic hydrocarbon metabolism" NARROW [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006726 +name: eye pigment biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] +synonym: "eye pigment anabolism" EXACT [] +synonym: "eye pigment biosynthesis" EXACT [] +synonym: "eye pigment formation" EXACT [] +synonym: "eye pigment synthesis" EXACT [] +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0006727 +name: ommochrome biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ommochrome anabolism" EXACT [] +synonym: "ommochrome biosynthesis" EXACT [] +synonym: "ommochrome formation" EXACT [] +synonym: "ommochrome synthesis" EXACT [] +is_a: GO:0006726 ! eye pigment biosynthetic process +is_a: GO:0008055 ! ocellus pigment biosynthetic process +is_a: GO:0046152 ! ommochrome metabolic process + +[Term] +id: GO:0006728 +name: pteridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pteridine anabolism" EXACT [] +synonym: "pteridine biosynthesis" EXACT [] +synonym: "pteridine formation" EXACT [] +synonym: "pteridine synthesis" EXACT [] +synonym: "pterin biosynthesis" NARROW [] +synonym: "pterin biosynthetic process" NARROW [] +is_a: GO:0019889 ! pteridine metabolic process +is_a: GO:0042559 ! pteridine and derivative biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0006729 +name: tetrahydrobiopterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tetrahydrobiopterin anabolism" EXACT [] +synonym: "tetrahydrobiopterin biosynthesis" EXACT [] +synonym: "tetrahydrobiopterin formation" EXACT [] +synonym: "tetrahydrobiopterin synthesis" EXACT [] +is_a: GO:0042559 ! pteridine and derivative biosynthetic process +is_a: GO:0046146 ! tetrahydrobiopterin metabolic process + +[Term] +id: GO:0006730 +name: one-carbon compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving compounds containing a single carbon atom." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "one carbon compound metabolic process" EXACT [] +synonym: "one carbon compound metabolism" EXACT [] +synonym: "one-carbon compound metabolism" EXACT [] +xref: UM-BBD_pathwayID:C1cyc +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006731 +name: coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +is_obsolete: true +consider: GO:0006732 +consider: GO:0051189 + +[Term] +id: GO:0006732 +name: coenzyme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "coenzyme and prosthetic group metabolism" BROAD [] +synonym: "coenzyme metabolism" EXACT [] +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0006733 +name: oxidoreduction coenzyme metabolic process +namespace: biological_process +subset: gosubset_prok +synonym: "oxidoreduction coenzyme metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0006734 +name: NADH metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] +subset: gosubset_prok +synonym: "NAD (reduced) metabolic process" EXACT [] +synonym: "NAD (reduced) metabolism" EXACT [] +synonym: "NADH metabolism" EXACT [] +synonym: "reduced NAD metabolic process" EXACT [] +synonym: "reduced NAD metabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT [] +is_a: GO:0006769 ! nicotinamide metabolic process + +[Term] +id: GO:0006735 +name: NADH regeneration +namespace: biological_process +subset: gosubset_prok +synonym: "NAD (reduced) regeneration" EXACT [] +synonym: "reduced NAD regeneration" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] +is_a: GO:0006734 ! NADH metabolic process + +[Term] +id: GO:0006738 +name: nicotinamide riboside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nicotinamide riboside breakdown" EXACT [] +synonym: "nicotinamide riboside catabolism" EXACT [] +synonym: "nicotinamide riboside degradation" EXACT [] +xref: MetaCyc:RIBOSYLNICOTINAMIDE+DEGRADATION +is_a: GO:0006734 ! NADH metabolic process +is_a: GO:0019364 ! pyridine nucleotide catabolic process +is_a: GO:0046495 ! nicotinamide riboside metabolic process + +[Term] +id: GO:0006739 +name: NADP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] +subset: gosubset_prok +synonym: "NAD phosphorylation and dephosphorylation" RELATED [] +synonym: "NADP (oxidized) metabolic process" EXACT [] +synonym: "NADP (oxidized) metabolism" EXACT [] +synonym: "NADP (reduced) metabolic process" EXACT [] +synonym: "NADP (reduced) metabolism" EXACT [] +synonym: "NADP metabolism" EXACT [] +synonym: "NADPH metabolic process" EXACT [] +synonym: "NADPH metabolism" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] +synonym: "oxidized NADP metabolic process" EXACT [] +synonym: "oxidized NADP metabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] +synonym: "reduced NADP metabolic process" EXACT [] +synonym: "reduced NADP metabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] +is_a: GO:0006769 ! nicotinamide metabolic process + +[Term] +id: GO:0006740 +name: NADPH regeneration +namespace: biological_process +subset: gosubset_prok +synonym: "NADP (reduced) regeneration" EXACT [] +synonym: "reduced NADP regeneration" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT [] +is_a: GO:0006739 ! NADP metabolic process + +[Term] +id: GO:0006741 +name: NADP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] +subset: gosubset_prok +synonym: "NADP (oxidized) biosynthesis" EXACT [] +synonym: "NADP (oxidized) biosynthetic process" EXACT [] +synonym: "NADP (reduced) biosynthesis" EXACT [] +synonym: "NADP (reduced) biosynthetic process" EXACT [] +synonym: "NADP anabolism" EXACT [] +synonym: "NADP biosynthesis" EXACT [] +synonym: "NADP formation" EXACT [] +synonym: "NADP synthesis" EXACT [] +synonym: "NADPH biosynthesis" EXACT [] +synonym: "NADPH biosynthetic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] +synonym: "oxidized NADP biosynthesis" EXACT [] +synonym: "oxidized NADP biosynthetic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] +synonym: "reduced NADP biosynthesis" EXACT [] +synonym: "reduced NADP biosynthetic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] +is_a: GO:0006739 ! NADP metabolic process +is_a: GO:0019363 ! pyridine nucleotide biosynthetic process + +[Term] +id: GO:0006742 +name: NADP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] +subset: gosubset_prok +synonym: "NADP (oxidized) catabolic process" EXACT [] +synonym: "NADP (oxidized) catabolism" EXACT [] +synonym: "NADP (reduced) catabolic process" EXACT [] +synonym: "NADP (reduced) catabolism" EXACT [] +synonym: "NADP breakdown" EXACT [] +synonym: "NADP catabolism" EXACT [] +synonym: "NADP degradation" EXACT [] +synonym: "NADPH catabolic process" EXACT [] +synonym: "NADPH catabolism" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] +synonym: "oxidized NADP catabolic process" EXACT [] +synonym: "oxidized NADP catabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] +synonym: "reduced NADP catabolic process" EXACT [] +synonym: "reduced NADP catabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] +is_a: GO:0006739 ! NADP metabolic process +is_a: GO:0019364 ! pyridine nucleotide catabolic process + +[Term] +id: GO:0006743 +name: ubiquinone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +subset: gosubset_prok +synonym: "coenzyme Q metabolic process" EXACT [] +synonym: "coenzyme Q metabolism" EXACT [] +synonym: "coenzyme Q6 metabolic process" NARROW [] +synonym: "coenzyme Q6 metabolism" NARROW [] +synonym: "ubiquinone metabolism" EXACT [] +is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process +is_a: GO:0042375 ! quinone cofactor metabolic process + +[Term] +id: GO:0006744 +name: ubiquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +subset: gosubset_prok +synonym: "coenzyme Q biosynthesis" EXACT [] +synonym: "coenzyme Q biosynthetic process" EXACT [] +synonym: "coenzyme Q10 biosynthesis" NARROW [] +synonym: "coenzyme Q10 biosynthetic process" NARROW [] +synonym: "coenzyme Q6 biosynthesis" NARROW [] +synonym: "coenzyme Q6 biosynthetic process" NARROW [] +synonym: "coenzyme Q8 biosynthesis" NARROW [] +synonym: "coenzyme Q8 biosynthetic process" NARROW [] +synonym: "coenzyme Q9 biosynthesis" NARROW [] +synonym: "coenzyme Q9 biosynthetic process" NARROW [] +synonym: "ubiquinone anabolism" EXACT [] +synonym: "ubiquinone biosynthesis" EXACT [] +synonym: "ubiquinone formation" EXACT [] +synonym: "ubiquinone synthesis" EXACT [] +xref: MetaCyc:UBISYN-PWY +is_a: GO:0006743 ! ubiquinone metabolic process +is_a: GO:0045426 ! quinone cofactor biosynthetic process + +[Term] +id: GO:0006746 +name: FADH2 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the reduced form of flavin-adenine dinucleotide." [GOC:ai] +subset: gosubset_prok +synonym: "FADH2 metabolism" EXACT [] +is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process + +[Term] +id: GO:0006747 +name: FAD biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "FAD anabolism" EXACT [] +synonym: "FAD biosynthesis" EXACT [] +synonym: "FAD formation" EXACT [] +synonym: "FAD synthesis" EXACT [] +synonym: "flavin adenine dinucleotide biosynthesis" EXACT [] +synonym: "flavin adenine dinucleotide biosynthetic process" EXACT [] +synonym: "flavin-adenine dinucleotide biosynthesis" EXACT [] +synonym: "flavin-adenine dinucleotide biosynthetic process" EXACT [] +xref: MetaCyc:RIBOSYN2-PWYRI +is_a: GO:0006746 ! FADH2 metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0042727 ! riboflavin and derivative biosynthetic process +is_a: GO:0046443 ! FAD metabolic process + +[Term] +id: GO:0006748 +name: lipoamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "lipoamide metabolism" EXACT [] +is_a: GO:0000273 ! lipoic acid metabolic process + +[Term] +id: GO:0006749 +name: glutathione metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glutathione metabolism" EXACT [] +synonym: "oxidized glutathione reduction" NARROW [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0006750 +name: glutathione biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glutathione anabolism" EXACT [] +synonym: "glutathione biosynthesis" EXACT [] +synonym: "glutathione formation" EXACT [] +synonym: "glutathione synthesis" EXACT [] +xref: MetaCyc:GLUTATHIONESYN-PWY +is_a: GO:0006749 ! glutathione metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0006751 +name: glutathione catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glutathione breakdown" EXACT [] +synonym: "glutathione catabolism" EXACT [] +synonym: "glutathione degradation" EXACT [] +is_a: GO:0006749 ! glutathione metabolic process +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0006752 +name: group transfer coenzyme metabolic process +namespace: biological_process +subset: gosubset_prok +synonym: "group transfer coenzyme metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0006753 +name: nucleoside phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] +subset: gosubset_prok +synonym: "nucleoside phosphate metabolism" EXACT [] +is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process + +[Term] +id: GO:0006754 +name: ATP biosynthetic process +namespace: biological_process +alt_id: GO:0006758 +def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ATP anabolism" EXACT [] +synonym: "ATP biosynthesis" EXACT [] +synonym: "ATP formation" EXACT [] +synonym: "ATP synthesis" EXACT [] +xref: Reactome:164832 +xref: Reactome:164840 +xref: Reactome:204646 +xref: Reactome:205713 +xref: Reactome:213726 +xref: Reactome:215073 +xref: Reactome:223471 +xref: Reactome:224346 +xref: Reactome:231946 +xref: Reactome:232930 +xref: Reactome:239869 +xref: Reactome:241125 +xref: Reactome:246059 +xref: Reactome:246657 +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046034 ! ATP metabolic process + +[Term] +id: GO:0006755 +name: carbamoyl phosphate-ADP transphosphorylation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2). +is_obsolete: true + +[Term] +id: GO:0006756 +name: AMP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006754 ! ATP biosynthetic process +is_a: GO:0046033 ! AMP metabolic process +is_a: GO:0046940 ! nucleoside monophosphate phosphorylation + +[Term] +id: GO:0006757 +name: ADP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0006754 ! ATP biosynthetic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0006759 +name: ATP regeneration +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006754 ! ATP biosynthetic process + +[Term] +id: GO:0006760 +name: folic acid and derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving folic acid and its derivatives." [GOC:ai] +subset: gosubset_prok +synonym: "folate and derivative metabolic process" EXACT [] +synonym: "folate and derivative metabolism" EXACT [] +synonym: "folic acid and derivative metabolism" EXACT [] +synonym: "vitamin B9 and derivative metabolic process" EXACT [] +synonym: "vitamin B9 and derivative metabolism" EXACT [] +synonym: "vitamin M and derivative metabolic process" EXACT [] +synonym: "vitamin M and derivative metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006752 ! group transfer coenzyme metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0006761 +name: dihydrofolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai] +subset: gosubset_prok +synonym: "7,8-dihydrofolate biosynthesis" EXACT [] +synonym: "7,8-dihydrofolate biosynthetic process" EXACT [] +synonym: "dihydrofolate anabolism" EXACT [] +synonym: "dihydrofolate biosynthesis" EXACT [] +synonym: "dihydrofolate formation" EXACT [] +synonym: "dihydrofolate synthesis" EXACT [] +is_a: GO:0009396 ! folic acid and derivative biosynthetic process +is_a: GO:0046452 ! dihydrofolate metabolic process + +[Term] +id: GO:0006762 +name: dihydrofolate reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0004146 +consider: GO:0046452 + +[Term] +id: GO:0006766 +name: vitamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "vitamin metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006767 +name: water-soluble vitamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] +subset: gosubset_prok +synonym: "water-soluble vitamin metabolism" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0006768 +name: biotin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "biotin metabolism" EXACT [] +synonym: "vitamin B7 metabolic process" EXACT [] +synonym: "vitamin B7 metabolism" EXACT [] +synonym: "vitamin H metabolic process" EXACT [] +synonym: "vitamin H metabolism" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0006769 +name: nicotinamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "niacin metabolic process" BROAD [] +synonym: "niacin metabolism" BROAD [] +synonym: "nicotinamide metabolism" EXACT [] +synonym: "vitamin B3 metabolic process" BROAD [] +synonym: "vitamin B3 metabolism" BROAD [] +xref: MetaCyc:PWY-5083 +is_a: GO:0019362 ! pyridine nucleotide metabolic process + +[Term] +id: GO:0006771 +name: riboflavin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "riboflavin metabolism" EXACT [] +synonym: "vitamin B2 metabolic process" EXACT [] +synonym: "vitamin B2 metabolism" EXACT [] +synonym: "vitamin G metabolic process" EXACT [] +synonym: "vitamin G metabolism" EXACT [] +is_a: GO:0042726 ! riboflavin and derivative metabolic process + +[Term] +id: GO:0006772 +name: thiamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "thiamin metabolism" EXACT [] +synonym: "thiamine metabolic process" EXACT [] +synonym: "thiamine metabolism" EXACT [] +synonym: "vitamin B1 metabolic process" EXACT [] +synonym: "vitamin B1 metabolism" EXACT [] +is_a: GO:0042723 ! thiamin and derivative metabolic process + +[Term] +id: GO:0006774 +name: vitamin B12 reduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +consider: GO:0009235 +consider: GO:0050453 + +[Term] +id: GO:0006775 +name: fat-soluble vitamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fat-soluble vitamin metabolism" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0006776 +name: vitamin A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "vitamin A metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process + +[Term] +id: GO:0006777 +name: Mo-molybdopterin cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] +subset: gosubset_prok +synonym: "Mo-molybdopterin cofactor anabolism" EXACT [] +synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT [] +synonym: "Mo-molybdopterin cofactor formation" EXACT [] +synonym: "Mo-molybdopterin cofactor synthesis" EXACT [] +synonym: "Moco biosynthesis" EXACT [] +synonym: "Moco biosynthetic process" EXACT [] +synonym: "molybdenum cofactor biosynthetic process" RELATED [] +xref: MetaCyc:PWY-5354 +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process +is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process +is_a: GO:0042559 ! pteridine and derivative biosynthetic process + +[Term] +id: GO:0006778 +name: porphyrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "porphyrin metabolism" EXACT [] +xref: Reactome:189445 +xref: Reactome:211983 +xref: Reactome:221747 +xref: Reactome:230328 +xref: Reactome:238365 +xref: Reactome:244922 +xref: Reactome:249883 +xref: Reactome:252549 +xref: Reactome:255726 +xref: Reactome:259119 +xref: Reactome:262477 +xref: Reactome:265308 +xref: Reactome:268438 +xref: Reactome:274151 +xref: Reactome:280624 +xref: Reactome:286643 +xref: Reactome:288330 +xref: Reactome:289847 +xref: Reactome:290388 +xref: Reactome:291767 +xref: Reactome:292417 +xref: Reactome:293743 +is_a: GO:0033013 ! tetrapyrrole metabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0006779 +name: porphyrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "porphyrin anabolism" EXACT [] +synonym: "porphyrin biosynthesis" EXACT [] +synonym: "porphyrin formation" EXACT [] +synonym: "porphyrin synthesis" EXACT [] +is_a: GO:0006778 ! porphyrin metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process +is_a: GO:0051188 ! cofactor biosynthetic process + +[Term] +id: GO:0006780 +name: uroporphyrinogen III biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai] +subset: gosubset_prok +synonym: "uroporphyrinogen III anabolism" EXACT [] +synonym: "uroporphyrinogen III biosynthesis" EXACT [] +synonym: "uroporphyrinogen III formation" EXACT [] +synonym: "uroporphyrinogen III synthesis" EXACT [] +is_a: GO:0046502 ! uroporphyrinogen III metabolic process +relationship: part_of GO:0006779 ! porphyrin biosynthetic process + +[Term] +id: GO:0006781 +name: succinyl-CoA pathway +namespace: biological_process +def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479] +subset: gosubset_prok +synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT [] +synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT [] +synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT [] +synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT [] +synonym: "succinyl CoA pathway" EXACT [] +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0006779 ! porphyrin biosynthetic process +relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process + +[Term] +id: GO:0006782 +name: protoporphyrinogen IX biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] +subset: gosubset_prok +synonym: "protoporphyrinogen IX anabolism" EXACT [] +synonym: "protoporphyrinogen IX biosynthesis" EXACT [] +synonym: "protoporphyrinogen IX formation" EXACT [] +synonym: "protoporphyrinogen IX synthesis" EXACT [] +is_a: GO:0006779 ! porphyrin biosynthetic process +is_a: GO:0046501 ! protoporphyrinogen IX metabolic process +relationship: part_of GO:0006783 ! heme biosynthetic process + +[Term] +id: GO:0006783 +name: heme biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] +subset: gosubset_prok +synonym: "haem biosynthesis" EXACT [] +synonym: "haem biosynthetic process" EXACT [] +synonym: "heme anabolism" EXACT [] +synonym: "heme biosynthesis" EXACT [] +synonym: "heme formation" EXACT [] +synonym: "heme synthesis" EXACT [] +xref: MetaCyc:HEME+BIOSYNTHESIS+II +xref: MetaCyc:HEMESYN2-PWY +xref: Reactome:189451 +xref: Reactome:211636 +xref: Reactome:221408 +xref: Reactome:230043 +xref: Reactome:238061 +xref: Reactome:244675 +xref: Reactome:249768 +xref: Reactome:252401 +xref: Reactome:255559 +xref: Reactome:258933 +xref: Reactome:262307 +xref: Reactome:265158 +xref: Reactome:268284 +xref: Reactome:273965 +xref: Reactome:280444 +xref: Reactome:286466 +xref: Reactome:288237 +xref: Reactome:289786 +xref: Reactome:290342 +xref: Reactome:291687 +xref: Reactome:292362 +xref: Reactome:293665 +is_a: GO:0006779 ! porphyrin biosynthetic process +is_a: GO:0042168 ! heme metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0006784 +name: heme a biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "haem a biosynthesis" EXACT [] +synonym: "haem a biosynthetic process" EXACT [] +synonym: "heme a anabolism" EXACT [] +synonym: "heme a biosynthesis" EXACT [] +synonym: "heme a formation" EXACT [] +synonym: "heme a synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046160 ! heme a metabolic process + +[Term] +id: GO:0006785 +name: heme b biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25] +subset: gosubset_prok +synonym: "haem b biosynthesis" EXACT [] +synonym: "haem b biosynthetic process" EXACT [] +synonym: "heme b anabolism" EXACT [] +synonym: "heme b biosynthesis" EXACT [] +synonym: "heme b formation" EXACT [] +synonym: "heme b synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046492 ! heme b metabolic process + +[Term] +id: GO:0006786 +name: heme c biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "haem c biosynthesis" EXACT [] +synonym: "haem c biosynthetic process" EXACT [] +synonym: "heme c anabolism" EXACT [] +synonym: "heme c biosynthesis" EXACT [] +synonym: "heme c formation" EXACT [] +synonym: "heme c synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046162 ! heme c metabolic process + +[Term] +id: GO:0006787 +name: porphyrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "porphyrin breakdown" EXACT [] +synonym: "porphyrin catabolism" EXACT [] +synonym: "porphyrin degradation" EXACT [] +is_a: GO:0006778 ! porphyrin metabolic process +is_a: GO:0033015 ! tetrapyrrole catabolic process +is_a: GO:0051187 ! cofactor catabolic process + +[Term] +id: GO:0006788 +name: heme oxidation +namespace: biological_process +subset: gosubset_prok +synonym: "haem oxidation" EXACT [] +is_a: GO:0042168 ! heme metabolic process +relationship: part_of GO:0006787 ! porphyrin catabolic process + +[Term] +id: GO:0006789 +name: bilirubin conjugation +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006787 ! porphyrin catabolic process + +[Term] +id: GO:0006790 +name: sulfur metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] +subset: gosubset_prok +synonym: "sulfur metabolism" EXACT [] +synonym: "sulphur metabolic process" EXACT [] +synonym: "sulphur metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006791 +name: sulfur utilization +namespace: biological_process +subset: gosubset_prok +synonym: "sulphur utilization" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0006792 +name: regulation of sulfur utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of sulphur utilization" EXACT [] +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: regulates GO:0006791 ! sulfur utilization + +[Term] +id: GO:0006793 +name: phosphorus metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "phosphorus metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006794 +name: phosphorus utilization +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0006795 +name: regulation of phosphorus utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: regulates GO:0006794 ! phosphorus utilization + +[Term] +id: GO:0006796 +name: phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] +subset: gosubset_prok +synonym: "phosphate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0006797 +name: polyphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyphosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate metabolic process + +[Term] +id: GO:0006798 +name: polyphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyphosphate breakdown" EXACT [] +synonym: "polyphosphate catabolism" EXACT [] +synonym: "polyphosphate degradation" EXACT [] +is_a: GO:0006797 ! polyphosphate metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0006799 +name: polyphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyphosphate anabolism" EXACT [] +synonym: "polyphosphate biosynthesis" EXACT [] +synonym: "polyphosphate formation" EXACT [] +synonym: "polyphosphate synthesis" EXACT [] +is_a: GO:0006797 ! polyphosphate metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0006800 +name: oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731] +subset: goslim_pir +subset: gosubset_prok +synonym: "oxygen and active oxygen species metabolism" EXACT [] +synonym: "oxygen and AOS metabolism" EXACT [] +synonym: "oxygen and reactive oxidative species metabolism" EXACT [] +synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT [] +synonym: "oxygen and reactive oxygen species metabolism" EXACT [] +synonym: "oxygen and ROI metabolism" EXACT [] +synonym: "oxygen and ROS metabolic process" EXACT [] +synonym: "oxygen and ROS metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006801 +name: superoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "oxygen free radical metabolic process" EXACT [] +synonym: "oxygen free radical metabolism" EXACT [] +synonym: "superoxide free radical metabolic process" EXACT [] +synonym: "superoxide free radical metabolism" EXACT [] +synonym: "superoxide metabolism" EXACT [] +is_a: GO:0006800 ! oxygen and reactive oxygen species metabolic process + +[Term] +id: GO:0006802 +name: catalase reaction +namespace: biological_process +def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904] +comment: This term was made obsolete because it represents a molecular function. +synonym: "hydroperoxidase reaction" RELATED [] +is_obsolete: true +consider: GO:0004096 + +[Term] +id: GO:0006803 +name: glutathione conjugation reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0004364 + +[Term] +id: GO:0006804 +name: peroxidase reaction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0004601 + +[Term] +id: GO:0006805 +name: xenobiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] +subset: goslim_pir +subset: gosubset_prok +synonym: "xenobiotic metabolism" EXACT [] +xref: Reactome:140191 +xref: Reactome:140192 +xref: Reactome:156580 +xref: Reactome:156587 +xref: Reactome:159424 +xref: Reactome:159443 +xref: Reactome:159566 +xref: Reactome:159567 +xref: Reactome:159574 +xref: Reactome:177128 +xref: Reactome:177135 +xref: Reactome:177157 +xref: Reactome:177160 +xref: Reactome:177162 +xref: Reactome:205900 +xref: Reactome:205904 +xref: Reactome:209998 +xref: Reactome:210969 +xref: Reactome:210971 +xref: Reactome:211692 +xref: Reactome:211879 +xref: Reactome:211922 +xref: Reactome:211957 +xref: Reactome:211990 +xref: Reactome:212010 +xref: Reactome:212092 +xref: Reactome:212099 +xref: Reactome:215453 +xref: Reactome:215472 +xref: Reactome:219821 +xref: Reactome:220815 +xref: Reactome:220816 +xref: Reactome:221463 +xref: Reactome:221644 +xref: Reactome:221687 +xref: Reactome:221722 +xref: Reactome:221754 +xref: Reactome:221774 +xref: Reactome:221850 +xref: Reactome:221858 +xref: Reactome:224628 +xref: Reactome:229483 +xref: Reactome:230090 +xref: Reactome:230274 +xref: Reactome:230305 +xref: Reactome:230336 +xref: Reactome:230352 +xref: Reactome:230418 +xref: Reactome:230430 +xref: Reactome:238345 +xref: Reactome:238372 +xref: Reactome:238460 +xref: Reactome:244903 +xref: Reactome:244929 +xref: Reactome:245001 +xref: Reactome:249796 +xref: Reactome:249886 +xref: Reactome:249900 +xref: Reactome:252581 +xref: Reactome:252605 +xref: Reactome:252616 +xref: Reactome:255787 +xref: Reactome:255792 +xref: Reactome:255801 +xref: Reactome:259107 +xref: Reactome:259123 +xref: Reactome:259185 +xref: Reactome:262466 +xref: Reactome:262541 +xref: Reactome:262552 +xref: Reactome:265343 +xref: Reactome:265370 +xref: Reactome:265376 +xref: Reactome:268425 +xref: Reactome:268495 +xref: Reactome:268507 +xref: Reactome:274142 +xref: Reactome:274222 +xref: Reactome:274231 +xref: Reactome:280615 +xref: Reactome:280691 +xref: Reactome:280700 +xref: Reactome:282894 +xref: Reactome:282907 +xref: Reactome:282919 +xref: Reactome:286684 +xref: Reactome:286712 +xref: Reactome:286726 +xref: Reactome:288352 +xref: Reactome:288380 +xref: Reactome:289869 +xref: Reactome:289873 +xref: Reactome:289884 +xref: Reactome:290404 +xref: Reactome:290420 +xref: Reactome:291786 +xref: Reactome:291792 +xref: Reactome:291801 +xref: Reactome:292433 +xref: Reactome:292441 +xref: Reactome:293733 +xref: Reactome:293771 +xref: Reactome:293777 +is_a: GO:0044237 ! cellular metabolic process +relationship: part_of GO:0009410 ! response to xenobiotic stimulus + +[Term] +id: GO:0006806 +name: insecticide resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0017085 + +[Term] +id: GO:0006807 +name: nitrogen compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node. +subset: goslim_pir +subset: gosubset_prok +synonym: "nitrogen compound metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0006808 +name: regulation of nitrogen utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0006809 +name: nitric oxide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] +subset: gosubset_prok +synonym: "nitric oxide anabolism" EXACT [] +synonym: "nitric oxide biosynthesis" EXACT [] +synonym: "nitric oxide formation" EXACT [] +synonym: "nitric oxide synthesis" EXACT [] +is_a: GO:0044271 ! nitrogen compound biosynthetic process +is_a: GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:0006810 +name: transport +namespace: biological_process +def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism." [GOC:mah] +comment: Note that 'electron transport ; GO:0006118' is not a child of transport because electron transport is not a type of directed movement of substances. +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "small molecule transport" NARROW [] +synonym: "solute:solute exchange" NARROW [] +is_a: GO:0051234 ! establishment of localization + +[Term] +id: GO:0006811 +name: ion transport +namespace: biological_process +def: "The directed movement of charged atoms or small charged molecules into, out of, within or between cells." [GOC:ai] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006812 +name: cation transport +namespace: biological_process +alt_id: GO:0006819 +def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006811 ! ion transport + +[Term] +id: GO:0006813 +name: potassium ion transport +namespace: biological_process +def: "The directed movement of potassium ions (K+) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "K+ conductance" EXACT [] +synonym: "potassium conductance" NARROW [] +synonym: "potassium ion conductance" NARROW [] +synonym: "potassium transport" EXACT [] +synonym: "sodium/potassium transport" BROAD [] +is_a: GO:0015672 ! monovalent inorganic cation transport +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0006814 +name: sodium ion transport +namespace: biological_process +alt_id: GO:0006834 +def: "The directed movement of sodium ions (Na+) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] +synonym: "sodium transport" EXACT [] +synonym: "sodium/potassium transport" BROAD [] +synonym: "sodium:calcium exchange" NARROW [] +synonym: "sodium:solute transport" NARROW [] +is_a: GO:0015672 ! monovalent inorganic cation transport +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0006815 +name: sodium/potassium transport +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +is_obsolete: true +consider: GO:0006813 +consider: GO:0006814 + +[Term] +id: GO:0006816 +name: calcium ion transport +namespace: biological_process +def: "The directed movement of calcium (Ca) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "calcium transport" EXACT [] +synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] +synonym: "sodium:calcium exchange" NARROW [] +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0006817 +name: phosphate transport +namespace: biological_process +def: "The directed movement of phosphate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0006818 +name: hydrogen transport +namespace: biological_process +def: "The directed movement of hydrogen (H2 or H+), into, out of, within or between cells." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006820 +name: anion transport +namespace: biological_process +alt_id: GO:0006822 +def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006811 ! ion transport + +[Term] +id: GO:0006821 +name: chloride transport +namespace: biological_process +def: "The directed movement of chloride into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0006823 +name: heavy metal ion transport +namespace: biological_process +def: "OBSOLETE. The directed movement of heavy metal ions into, out of, within or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +is_obsolete: true +consider: GO:0030001 + +[Term] +id: GO:0006824 +name: cobalt ion transport +namespace: biological_process +def: "The directed movement of cobalt (Co) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "cobalt transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport + +[Term] +id: GO:0006825 +name: copper ion transport +namespace: biological_process +def: "The directed movement of copper (Cu) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006826 +name: iron ion transport +namespace: biological_process +alt_id: GO:0015681 +def: "The directed movement of iron (Fe) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "iron transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport + +[Term] +id: GO:0006827 +name: high-affinity iron ion transport +namespace: biological_process +def: "The directed, high-affinity movement of iron (Fe) ions into, out of, within or between cells. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +subset: gosubset_prok +synonym: "high affinity iron ion transport" EXACT [] +is_a: GO:0034755 ! transmembrane iron ion transport + +[Term] +id: GO:0006828 +name: manganese ion transport +namespace: biological_process +def: "The directed movement of manganese (Mn) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006829 +name: zinc ion transport +namespace: biological_process +def: "The directed movement of zinc (Zn) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006830 +name: high-affinity zinc ion transport +namespace: biological_process +def: "The directed, high-affinity movement of zinc (Zn) ions into, out of, within or between cells. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +is_a: GO:0006829 ! zinc ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0006831 +name: low-affinity zinc ion transport +namespace: biological_process +def: "The directed, low-affinity movement of zinc (Zn) ions into, out of, within or between cells. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] +is_a: GO:0006829 ! zinc ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0006832 +name: small molecule transport +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0006810 + +[Term] +id: GO:0006833 +name: water transport +namespace: biological_process +def: "The directed movement of water (H2O) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0042044 ! fluid transport + +[Term] +id: GO:0006835 +name: dicarboxylic acid transport +namespace: biological_process +alt_id: GO:0006841 +def: "The directed movement of dicarboxylic acids into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +synonym: "sodium:dicarboxylate transport" RELATED [] +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006836 +name: neurotransmitter transport +namespace: biological_process +def: "The directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] +subset: goslim_pir +synonym: "sodium:neurotransmitter transport" NARROW [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006837 +name: serotonin transport +namespace: biological_process +def: "The directed movement of serotonin into, out of, within or between cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006838 +name: allantoin/allantoate transport +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +is_obsolete: true +consider: GO:0015719 +consider: GO:0015720 + +[Term] +id: GO:0006839 +name: mitochondrial transport +namespace: biological_process +def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] +synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] +synonym: "mitochondrial aspartate/glutamate transport" NARROW [] +synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0006840 +name: mitochondrial alpha-ketoglutarate/malate transport +namespace: biological_process +def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "mitochondrial oxoglutarate/malate transport" EXACT [] +is_obsolete: true +replaced_by: GO:0006839 +replaced_by: GO:0015367 +replaced_by: GO:0015742 +replaced_by: GO:0015743 + +[Term] +id: GO:0006842 +name: tricarboxylic acid transport +namespace: biological_process +def: "The directed movement of tricarboxylic acids into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006843 +name: mitochondrial citrate transport +namespace: biological_process +def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015746 ! citrate transport + +[Term] +id: GO:0006844 +name: acyl carnitine transport +namespace: biological_process +def: "The directed movement of acyl carnitine into, out of, within or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0006845 +name: mitochondrial aspartate/glutamate transport +namespace: biological_process +def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +replaced_by: GO:0006839 +replaced_by: GO:0015810 +replaced_by: GO:0015813 + +[Term] +id: GO:0006846 +name: acetate transport +namespace: biological_process +def: "The directed movement of acetate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0006847 +name: plasma membrane acetate transport +namespace: biological_process +def: "The directed movement of acetate across a plasma membrane." [GOC:ai] +is_a: GO:0006846 ! acetate transport + +[Term] +id: GO:0006848 +name: pyruvate transport +namespace: biological_process +def: "The directed movement of pyruvate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0006849 +name: plasma membrane pyruvate transport +namespace: biological_process +def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai] +is_a: GO:0006848 ! pyruvate transport + +[Term] +id: GO:0006850 +name: mitochondrial pyruvate transport +namespace: biological_process +def: "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0006848 ! pyruvate transport + +[Term] +id: GO:0006851 +name: mitochondrial calcium ion transport +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion." [GOC:ai] +synonym: "mitochondrial calcium transport" EXACT [] +is_a: GO:0006816 ! calcium ion transport +is_a: GO:0006839 ! mitochondrial transport + +[Term] +id: GO:0006852 +name: mitochondrial sodium/calcium ion exchange +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents function rather than a process. +synonym: "mitochondrial sodium/calcium exchange" EXACT [] +is_obsolete: true +replaced_by: GO:0006814 +replaced_by: GO:0006816 +replaced_by: GO:0006839 +consider: GO:0005432 + +[Term] +id: GO:0006853 +name: carnitine shuttle +namespace: biological_process +def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015879 ! carnitine transport +is_a: GO:0015909 ! long-chain fatty acid transport +is_a: GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0006854 +name: ATP/ADP exchange +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0005471 + +[Term] +id: GO:0006855 +name: multidrug transport +namespace: biological_process +def: "The directed movement of drugs into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0006856 +name: eye pigment precursor transport +namespace: biological_process +def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of, within or between cells." [GOC:ai] +is_a: GO:0006810 ! transport +relationship: part_of GO:0048066 ! pigmentation during development + +[Term] +id: GO:0006857 +name: oligopeptide transport +namespace: biological_process +def: "The directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0006858 +name: extracellular transport +namespace: biological_process +def: "The transport of substances that occurs outside cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006859 +name: extracellular carbohydrate transport +namespace: biological_process +def: "The directed extracellular movement of carbohydrates." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006858 ! extracellular transport +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0006860 +name: extracellular amino acid transport +namespace: biological_process +def: "The directed extracellular movement of amino acids." [GOC:ai] +is_a: GO:0006858 ! extracellular transport +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0006862 +name: nucleotide transport +namespace: biological_process +def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0006863 +name: purine transport +namespace: biological_process +alt_id: GO:0015852 +def: "The directed movement of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015851 ! nucleobase transport + +[Term] +id: GO:0006864 +name: pyrimidine nucleotide transport +namespace: biological_process +def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0006865 +name: amino acid transport +namespace: biological_process +alt_id: GO:0006866 +def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0015837 ! amine transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006867 +name: asparagine transport +namespace: biological_process +def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-asparagine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0006868 +name: glutamine transport +namespace: biological_process +alt_id: GO:0015815 +def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-glutamine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0006869 +name: lipid transport +namespace: biological_process +def: "The directed movement of lipids into, out of, within or between cells. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006873 +name: cellular ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of ions within a cell or between a cell and its external environment." [GOC:mah] +subset: gosubset_prok +is_a: GO:0050801 ! ion homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0006874 +name: cellular calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions within a cell or between a cell and its external environment." [GOC:ceb] +synonym: "regulation of calcium ion concentration" BROAD [] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055074 ! calcium ion homeostasis + +[Term] +id: GO:0006875 +name: cellular metal ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of metal ions within a cell or between a cell and its external environment." [GOC:ai] +subset: gosubset_prok +synonym: "cellular heavy metal ion homeostasis" NARROW [] +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0055065 ! metal ion homeostasis + +[Term] +id: GO:0006876 +name: cellular cadmium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of cadmium ions within a cell or between a cell and its external environment." [GOC:ai] +synonym: "cadmium homeostasis" BROAD [] +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055073 ! cadmium ion homeostasis + +[Term] +id: GO:0006877 +name: cellular cobalt ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of cobalt ions within a cell or between a cell and its external environment." [GOC:ai] +synonym: "cobalt homeostasis" BROAD [] +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055068 ! cobalt ion homeostasis + +[Term] +id: GO:0006878 +name: cellular copper ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of copper ions within a cell or between a cell and its external environment." [GOC:ai] +subset: gosubset_prok +synonym: "copper homeostasis" BROAD [] +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055070 ! copper ion homeostasis + +[Term] +id: GO:0006879 +name: cellular iron ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of iron ions within a cell or between a cell and its external environment." [GOC:ai] +subset: gosubset_prok +synonym: "iron homeostasis" BROAD [] +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055072 ! iron ion homeostasis + +[Term] +id: GO:0006880 +name: intracellular sequestering of iron ion +namespace: biological_process +def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai] +subset: gosubset_prok +synonym: "intracellular iron ion retention" EXACT [] +synonym: "intracellular iron ion sequestering" EXACT [] +synonym: "intracellular iron ion sequestration" EXACT [] +synonym: "intracellular iron ion storage" EXACT [] +synonym: "intracellular retention of iron ion" EXACT [] +synonym: "intracellular sequestration of iron ion" EXACT [] +synonym: "intracellular storage of iron ion" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0006879 ! cellular iron ion homeostasis + +[Term] +id: GO:0006881 +name: extracellular sequestering of iron ion +namespace: biological_process +def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai] +synonym: "extracellular iron ion retention" EXACT [] +synonym: "extracellular iron ion sequestering" EXACT [] +synonym: "extracellular iron ion sequestration" EXACT [] +synonym: "extracellular iron ion storage" EXACT [] +synonym: "extracellular retention of iron ion" EXACT [] +synonym: "extracellular sequestration of iron ion" EXACT [] +synonym: "extracellular storage of iron ion" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +relationship: part_of GO:0033212 ! iron assimilation + +[Term] +id: GO:0006882 +name: cellular zinc ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of zinc ions within a cell or between a cell and its external environment." [GOC:ai] +synonym: "zinc homeostasis" BROAD [] +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055069 ! zinc ion homeostasis + +[Term] +id: GO:0006883 +name: cellular sodium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of sodium ions within a cell or between a cell and its external environment." [GOC:ai] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0055078 ! sodium ion homeostasis + +[Term] +id: GO:0006884 +name: cell volume homeostasis +namespace: biological_process +def: "Any process involved in maintaining the equilibrium of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] +is_a: GO:0019725 ! cellular homeostasis + +[Term] +id: GO:0006885 +name: regulation of pH +namespace: biological_process +def: "Any process that modulates the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0006886 +name: intracellular protein transport +namespace: biological_process +def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] +subset: gosubset_prok +is_a: GO:0015031 ! protein transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0006887 +name: exocytosis +namespace: biological_process +alt_id: GO:0016194 +alt_id: GO:0016195 +def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] +subset: gosubset_prok +synonym: "nonselective vesicle exocytosis" RELATED [] +synonym: "vesicle exocytosis" EXACT [] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0006888 +name: ER to Golgi vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [ISBN:0716731363] +synonym: "endoplasmic reticulum to Golgi transport" EXACT [] +synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [] +synonym: "ER to Golgi transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006889 +name: regulation of calcium in ER +namespace: biological_process +def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators] +comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). +is_obsolete: true +consider: GO:0005783 +consider: GO:0006874 + +[Term] +id: GO:0006890 +name: retrograde vesicle-mediated transport, Golgi to ER +namespace: biological_process +def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] +synonym: "retrograde (Golgi to ER) transport" EXACT [] +synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT [] +synonym: "retrograde transport, Golgi to ER" EXACT [] +synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006891 +name: intra-Golgi vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] +synonym: "intra-Golgi transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006892 +name: post-Golgi vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] +synonym: "post-Golgi transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006893 +name: Golgi to plasma membrane transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] +synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] +is_a: GO:0006892 ! post-Golgi vesicle-mediated transport + +[Term] +id: GO:0006894 +name: Golgi to secretory vesicle transport +namespace: biological_process +def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363] +comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms. +synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT [] +is_obsolete: true +consider: GO:0055107 +consider: GO:0055108 + +[Term] +id: GO:0006895 +name: Golgi to endosome transport +namespace: biological_process +alt_id: GO:0048218 +def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832] +synonym: "Golgi to endosome vesicle-mediated transport" EXACT [] +synonym: "TGN to endosome transport" EXACT [] +synonym: "trans-Golgi to endosome transport" EXACT [] +is_a: GO:0006892 ! post-Golgi vesicle-mediated transport +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0006896 +name: Golgi to vacuole transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] +synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] +is_a: GO:0006892 ! post-Golgi vesicle-mediated transport +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0006897 +name: endocytosis +namespace: biological_process +alt_id: GO:0016193 +alt_id: GO:0016196 +def: "A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] +subset: gosubset_prok +synonym: "nonselective vesicle endocytosis" RELATED [] +synonym: "plasma membrane invagination" EXACT [] +synonym: "vesicle endocytosis" EXACT [] +is_a: GO:0010324 ! membrane invagination +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006898 +name: receptor-mediated endocytosis +namespace: biological_process +def: "The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [ISBN:0716731363] +synonym: "receptor mediated endocytosis" EXACT [] +xref: Reactome:171052 +xref: Reactome:171059 +xref: Reactome:171087 +xref: Reactome:171106 +xref: Reactome:171118 +xref: Reactome:171122 +xref: Reactome:171141 +xref: Reactome:174624 +xref: Reactome:174657 +xref: Reactome:174808 +xref: Reactome:206358 +xref: Reactome:206384 +xref: Reactome:206399 +xref: Reactome:209279 +xref: Reactome:209288 +xref: Reactome:209290 +xref: Reactome:209306 +xref: Reactome:209307 +xref: Reactome:211842 +xref: Reactome:215912 +xref: Reactome:215938 +xref: Reactome:215954 +xref: Reactome:219043 +xref: Reactome:219049 +xref: Reactome:219051 +xref: Reactome:219061 +xref: Reactome:219062 +xref: Reactome:221607 +xref: Reactome:227815 +xref: Reactome:227829 +xref: Reactome:227832 +xref: Reactome:227846 +xref: Reactome:227847 +xref: Reactome:230205 +xref: Reactome:233525 +xref: Reactome:233547 +xref: Reactome:233560 +xref: Reactome:236045 +xref: Reactome:236052 +xref: Reactome:236054 +xref: Reactome:236066 +xref: Reactome:236067 +xref: Reactome:238242 +xref: Reactome:243198 +xref: Reactome:243209 +xref: Reactome:243215 +xref: Reactome:243225 +xref: Reactome:243226 +xref: Reactome:244815 +xref: Reactome:248328 +xref: Reactome:249712 +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0006900 +name: membrane budding +namespace: biological_process +alt_id: GO:0006902 +def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jic, GOC:tb] +synonym: "membrane evagination" EXACT [] +synonym: "nonselective vesicle assembly" RELATED [] +synonym: "vesicle biosynthesis" EXACT [] +synonym: "vesicle budding" RELATED [] +synonym: "vesicle formation" EXACT [] +is_a: GO:0016044 ! membrane organization +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006901 +name: vesicle coating +namespace: biological_process +def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jic] +synonym: "vesicle coat assembly" BROAD [] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0006900 ! membrane budding + +[Term] +id: GO:0006903 +name: vesicle targeting +namespace: biological_process +def: "The process by which vesicles are directed to specific destination membranes, mediated by microtubules that grow between molecules at the vesicle membrane and target membrane surfaces." [GOC:isa_complete, PMID:11356872] +is_a: GO:0007017 ! microtubule-based process +relationship: part_of GO:0016192 ! vesicle-mediated transport +relationship: part_of GO:0051650 ! establishment of vesicle localization + +[Term] +id: GO:0006904 +name: vesicle docking during exocytosis +namespace: biological_process +def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during exocytosis." [GOC:jic] +subset: gosubset_prok +is_a: GO:0048278 ! vesicle docking +relationship: part_of GO:0006887 ! exocytosis + +[Term] +id: GO:0006905 +name: vesicle transport +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous. +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0006906 +name: vesicle fusion +namespace: biological_process +def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jic] +is_a: GO:0006944 ! membrane fusion +is_a: GO:0048284 ! organelle fusion +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006907 +name: pinocytosis +namespace: biological_process +def: "The process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "fluid-phase endocytosis" EXACT [] +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0006908 +name: clathrin-independent pinocytosis +namespace: biological_process +is_a: GO:0006907 ! pinocytosis + +[Term] +id: GO:0006909 +name: phagocytosis +namespace: biological_process +def: "The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0006910 +name: phagocytosis, recognition +namespace: biological_process +def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term GO:0008367 bacterial binding. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term GO:0001846 opsonin binding. +synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT [] +is_a: GO:0008037 ! cell recognition +relationship: part_of GO:0006909 ! phagocytosis + +[Term] +id: GO:0006911 +name: phagocytosis, engulfment +namespace: biological_process +def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"] +synonym: "phagosome biosynthesis" RELATED [] +synonym: "phagosome formation" RELATED [] +is_a: GO:0010324 ! membrane invagination +relationship: part_of GO:0006909 ! phagocytosis + +[Term] +id: GO:0006912 +name: phagosome formation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] +comment: This term was made obsolete because of the ambiguity in its meaning. +is_obsolete: true +consider: GO:0001845 +consider: GO:0006911 + +[Term] +id: GO:0006913 +name: nucleocytoplasmic transport +namespace: biological_process +alt_id: GO:0000063 +def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] +synonym: "nucleocytoplasmic shuttling" NARROW [] +is_a: GO:0051169 ! nuclear transport + +[Term] +id: GO:0006914 +name: autophagy +namespace: biological_process +def: "The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464] +subset: goslim_pir +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0006915 +name: apoptosis +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "apoptotic programmed cell death" EXACT [] +synonym: "programmed cell death by apoptosis" EXACT [] +synonym: "signaling (initiator) caspase activity" RELATED [] +synonym: "type I programmed cell death" NARROW [] +xref: Reactome:109581 +xref: Reactome:212025 +xref: Reactome:221788 +xref: Reactome:230365 +xref: Reactome:238478 +xref: Reactome:245020 +xref: Reactome:249908 +xref: Reactome:252627 +xref: Reactome:255810 +xref: Reactome:259206 +xref: Reactome:262565 +xref: Reactome:265386 +xref: Reactome:268517 +xref: Reactome:274243 +xref: Reactome:280709 +xref: Reactome:286733 +xref: Reactome:288390 +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0006916 +name: anti-apoptosis +namespace: biological_process +def: "A process which directly inhibits any of the steps required for cell death by apoptosis." [GOC:go_curators] +synonym: "apoptosis inhibitor activity" RELATED [] +is_a: GO:0043066 ! negative regulation of apoptosis + +[Term] +id: GO:0006917 +name: induction of apoptosis +namespace: biological_process +def: "A process that directly activates any of the steps required for cell death by apoptosis." [GOC:go_curators] +synonym: "activation of apoptosis" EXACT [] +synonym: "apoptosis activator activity" RELATED [] +synonym: "apoptosis signaling" BROAD [] +synonym: "commitment to apoptosis" EXACT [] +synonym: "induction of apoptosis by p53" NARROW [] +is_a: GO:0012502 ! induction of programmed cell death +is_a: GO:0043065 ! positive regulation of apoptosis + +[Term] +id: GO:0006918 +name: induction of apoptosis by p53 +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more accurate terms were created. +is_obsolete: true +consider: GO:0006917 + +[Term] +id: GO:0006919 +name: caspase activation +namespace: biological_process +def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] +xref: Reactome:211794 +xref: Reactome:221558 +xref: Reactome:230166 +xref: Reactome:69416 +is_a: GO:0043280 ! positive regulation of caspase activity +relationship: part_of GO:0008632 ! apoptotic program + +[Term] +id: GO:0006920 +name: commitment to apoptosis +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more accurate terms were created. +is_obsolete: true +consider: GO:0006917 + +[Term] +id: GO:0006921 +name: cell structure disassembly during apoptosis +namespace: biological_process +def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:mah] +synonym: "disassembly of cell structures" BROAD [] +is_a: GO:0022411 ! cellular component disassembly +relationship: part_of GO:0008632 ! apoptotic program + +[Term] +id: GO:0006922 +name: cleavage of lamin +namespace: biological_process +def: "The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, ISBN:0815332181] +is_a: GO:0006923 ! cleavage of cytoskeletal proteins during apoptosis + +[Term] +id: GO:0006923 +name: cleavage of cytoskeletal proteins during apoptosis +namespace: biological_process +def: "The proteolytic degradation of cytoskeletal proteins during apoptosis, leading to the collapse of cytoskeletal structures." [GOC:mah, ISBN:0815332181] +synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT [] +is_a: GO:0006921 ! cell structure disassembly during apoptosis + +[Term] +id: GO:0006924 +name: activated T cell apoptosis +namespace: biological_process +def: "The process of apoptosis in activated T cells." [GOC:jl] +synonym: "activated T cell programmed cell death by apoptosis" EXACT [] +synonym: "activated T lymphocyte apoptosis" EXACT [] +synonym: "activated T lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "activated T-cell apoptosis" EXACT [] +synonym: "activated T-cell programmed cell death by apoptosis" EXACT [] +synonym: "activated T-lymphocyte apoptosis" EXACT [] +synonym: "activated T-lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "apoptosis of activated T cells" EXACT [] +synonym: "apoptosis of activated T lymphocytes" EXACT [] +synonym: "apoptosis of activated T-cells" EXACT [] +synonym: "apoptosis of activated T-lymphocytes" EXACT [] +synonym: "peripheral killing of activated T cells" EXACT [] +synonym: "programmed cell death of activated T cells by apoptosis" EXACT [] +synonym: "programmed cell death of activated T lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death of activated T-cells by apoptosis" EXACT [] +synonym: "programmed cell death of activated T-lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death, activated T cells" EXACT [] +synonym: "programmed cell death, activated T lymphocytes" EXACT [] +synonym: "programmed cell death, activated T-cells" EXACT [] +synonym: "programmed cell death, activated T-lymphocytes" EXACT [] +is_a: GO:0006915 ! apoptosis +relationship: part_of GO:0043029 ! T cell homeostasis + +[Term] +id: GO:0006925 +name: inflammatory cell apoptosis +namespace: biological_process +def: "The process of apoptosis in inflammatory cells, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, http://www.mercksource.com/] +synonym: "apoptosis of inflammatory cells" EXACT [] +synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] +synonym: "killing of inflammatory cells" EXACT [] +synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] +synonym: "programmed cell death, inflammatory cells" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0006926 +name: virus-infected cell apoptosis +namespace: biological_process +def: "The process of apoptosis in cells infected with a virus." [GOC:jl] +synonym: "apoptosis of virus-infected cells" EXACT [] +synonym: "killing virus-infected cells" EXACT [] +synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT [] +synonym: "programmed cell death, virus-infected cells" EXACT [] +synonym: "virus-infected cell programmed cell death by apoptosis" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0006927 +name: transformed cell apoptosis +namespace: biological_process +def: "The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, MeSH:C04.697.152] +synonym: "apoptosis of transformed cells" EXACT [] +synonym: "killing transformed cells" EXACT [] +synonym: "programmed cell death of transformed cells by apoptosis" EXACT [] +synonym: "programmed cell death, transformed cells" EXACT [] +synonym: "transformed cell programmed cell death by apoptosis" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0006928 +name: cell motion +namespace: biological_process +def: "Any process involved in the controlled movement of a cell." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "cell locomotion" RELATED [] +synonym: "cell movement" EXACT [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0051674 ! localization of cell + +[Term] +id: GO:0006929 +name: substrate-bound cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0006930 +name: substrate-bound cell migration, cell extension +namespace: biological_process +def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486] +is_a: GO:0030031 ! cell projection biogenesis +relationship: part_of GO:0006929 ! substrate-bound cell migration + +[Term] +id: GO:0006931 +name: substrate-bound cell migration, cell attachment to substrate +namespace: biological_process +def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486] +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0006929 ! substrate-bound cell migration + +[Term] +id: GO:0006932 +name: substrate-bound cell migration, cell contraction +namespace: biological_process +def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486] +is_a: GO:0030029 ! actin filament-based process +relationship: part_of GO:0006929 ! substrate-bound cell migration + +[Term] +id: GO:0006933 +name: negative regulation of cell adhesion involved in substrate-bound cell migration +namespace: biological_process +def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] +synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007162 ! negative regulation of cell adhesion +relationship: part_of GO:0006929 ! substrate-bound cell migration + +[Term] +id: GO:0006934 +name: substrate-bound cell migration, adhesion receptor recycling +namespace: biological_process +def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043] +is_a: GO:0001881 ! receptor recycling +relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration + +[Term] +id: GO:0006935 +name: chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "taxis in response to chemical stimulus" EXACT [] +is_a: GO:0042221 ! response to chemical stimulus +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0006936 +name: muscle contraction +namespace: biological_process +def: "A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +is_a: GO:0003012 ! muscle system process + +[Term] +id: GO:0006937 +name: regulation of muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0006936 ! muscle contraction + +[Term] +id: GO:0006939 +name: smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "visceral muscle contraction" EXACT [] +is_a: GO:0006936 ! muscle contraction + +[Term] +id: GO:0006940 +name: regulation of smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] +is_a: GO:0006937 ! regulation of muscle contraction +relationship: regulates GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0006941 +name: striated muscle contraction +namespace: biological_process +def: "A process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "sarcomeric muscle contraction" EXACT [] +is_a: GO:0006936 ! muscle contraction + +[Term] +id: GO:0006942 +name: regulation of striated muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] +is_a: GO:0006937 ! regulation of muscle contraction +relationship: regulates GO:0006941 ! striated muscle contraction + +[Term] +id: GO:0006943 +name: chemi-mechanical coupling +namespace: biological_process +def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jic, http://www.m-w.com] +comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO. +synonym: "mechanochemical coupling" EXACT [] +is_obsolete: true +consider: GO:0009612 +consider: GO:0050954 + +[Term] +id: GO:0006944 +name: membrane fusion +namespace: biological_process +def: "The joining of two lipid bilayers to form a single membrane." [GOC:mah] +subset: goslim_goa +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0006945 +name: nuclear fusion during karyogamy +namespace: biological_process +def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101] +comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology. +is_obsolete: true +consider: GO:0000741 + +[Term] +id: GO:0006948 +name: induction by virus of cell-cell fusion in host +namespace: biological_process +def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325] +synonym: "viral-induced cell-cell fusion" EXACT [] +synonym: "viral-induced host cell-cell fusion" EXACT [] +synonym: "viral-induced membrane fusion" NARROW [] +is_a: GO:0019048 ! virus-host interaction + +[Term] +id: GO:0006949 +name: syncytium formation +namespace: biological_process +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +is_a: GO:0009987 ! cellular process +is_a: GO:0048646 ! anatomical structure formation + +[Term] +id: GO:0006950 +name: response to stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "response to abiotic stress" RELATED [] +synonym: "response to biotic stress" RELATED [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0006952 +name: defense response +namespace: biological_process +alt_id: GO:0002217 +alt_id: GO:0042829 +def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] +subset: gosubset_prok +synonym: "antimicrobial peptide activity" RELATED [] +synonym: "defence response" EXACT [] +synonym: "defense/immunity protein activity" RELATED [] +synonym: "physiological defense response" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0006953 +name: acute-phase response +namespace: biological_process +def: "Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0006954 +name: inflammatory response +namespace: biological_process +def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GOC:mtg_15nov05, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was improved by GO_REF:0000022. It was moved. +is_a: GO:0006952 ! defense response +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0006955 +name: immune response +namespace: biological_process +def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:add, GOC:mtg_15nov05] +comment: This term was improved by GO_REF:0000022. It was redefined and moved. +is_a: GO:0002376 ! immune system process +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0006956 +name: complement activation +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was improved by GO_REF:0000022. It was moved. +synonym: "complement activity" RELATED [] +synonym: "complement response" EXACT [] +xref: Reactome:166663 +xref: Reactome:211734 +xref: Reactome:221852 +xref: Reactome:230422 +is_a: GO:0002252 ! immune effector process +is_a: GO:0002253 ! activation of immune response +is_a: GO:0002541 ! activation of plasma proteins during acute inflammatory response +is_a: GO:0006959 ! humoral immune response + +[Term] +id: GO:0006957 +name: complement activation, alternative pathway +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +xref: Reactome:173736 +is_a: GO:0006956 ! complement activation +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0006958 +name: complement activation, classical pathway +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +xref: Reactome:173623 +xref: Reactome:211607 +xref: Reactome:221381 +is_a: GO:0006956 ! complement activation +relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0006959 +name: humoral immune response +namespace: biological_process +def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0006962 +name: male-specific antibacterial humoral response +namespace: biological_process +def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] +is_a: GO:0019731 ! antibacterial humoral response +is_a: GO:0050831 ! male-specific defense response to bacterium + +[Term] +id: GO:0006963 +name: positive regulation of antibacterial peptide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] +synonym: "activation of antibacterial peptide biosynthetic process" NARROW [] +synonym: "antibacterial peptide induction" EXACT [] +synonym: "antibacterial polypeptide induction" EXACT [] +synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW [] +synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT [] +is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process + +[Term] +id: GO:0006964 +name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] +synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] +synonym: "anti-Gram-negative bacterial peptide induction" EXACT [] +synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT [] +synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] +synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process +relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria + +[Term] +id: GO:0006965 +name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] +synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] +synonym: "anti-Gram-positive bacterial peptide induction" EXACT [] +synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT [] +synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] +synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process +relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria + +[Term] +id: GO:0006967 +name: positive regulation of antifungal peptide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] +synonym: "activation of antifungal peptide biosynthetic process" NARROW [] +synonym: "antifungal peptide induction" EXACT [] +synonym: "antifungal polypeptide induction" EXACT [] +synonym: "stimulation of antifungal peptide biosynthetic process" NARROW [] +synonym: "up regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "upregulation of antifungal peptide biosynthetic process" EXACT [] +is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process +relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process + +[Term] +id: GO:0006968 +name: cellular defense response +namespace: biological_process +alt_id: GO:0016066 +alt_id: GO:0016067 +def: "A defense response that is mediated by cells." [GOC:ebc] +comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes. +synonym: "cellular defence response" EXACT [] +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0006969 +name: melanotic tumor response +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] +comment: This term was made obsolete because it was undefined and represented an abnormal process. +synonym: "melanotic mass response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006970 +name: response to osmotic stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] +subset: gosubset_prok +synonym: "osmotic response" EXACT [] +synonym: "osmotic stress response" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0006971 +name: hypotonic response +namespace: biological_process +def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "hypo-osmotic response" EXACT [] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0006972 +name: hyperosmotic response +namespace: biological_process +def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "HOG response" EXACT [] +synonym: "hypertonic response" EXACT [] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0006973 +name: intracellular accumulation of glycerol +namespace: biological_process +def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666] +is_a: GO:0019725 ! cellular homeostasis +relationship: part_of GO:0006972 ! hyperosmotic response + +[Term] +id: GO:0006974 +name: response to DNA damage stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] +subset: gosubset_prok +synonym: "DNA damage response" EXACT [] +synonym: "response to genotoxic stress" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0006975 +name: DNA damage induced protein phosphorylation +namespace: biological_process +def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0034984 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0006977 +name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest +namespace: biological_process +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] +is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator +relationship: part_of GO:0031571 ! G1 DNA damage checkpoint + +[Term] +id: GO:0006978 +name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +namespace: biological_process +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] +is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator +is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription + +[Term] +id: GO:0006979 +name: response to oxidative stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] +subset: gosubset_prok +is_a: GO:0006950 ! response to stress +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0006980 +name: redox signal response +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:0051775 ! response to redox state + +[Term] +id: GO:0006981 +name: activation of SoxR protein +namespace: biological_process +def: "The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757] +subset: gosubset_prok +is_a: GO:0006980 ! redox signal response + +[Term] +id: GO:0006982 +name: response to lipid hydroperoxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149] +subset: gosubset_prok +synonym: "response to LHPO" EXACT [] +is_a: GO:0033194 ! response to hydroperoxide + +[Term] +id: GO:0006983 +name: ER overload response +namespace: biological_process +def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] +synonym: "endoplasmic reticulum overload response" EXACT [] +synonym: "EOR" EXACT [] +synonym: "ER-overload response" EXACT [] +is_a: GO:0006984 ! ER-nuclear signaling pathway +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:0006984 +name: ER-nuclear signaling pathway +namespace: biological_process +def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] +synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT [] +synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT [] +synonym: "ER to nucleus signaling pathway" EXACT [] +synonym: "ER to nucleus signalling pathway" EXACT [] +synonym: "ER-nuclear signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0006985 +name: positive regulation of NF-kappaB transcription factor activity by ER overload response +namespace: biological_process +def: "The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum." [GOC:dph, GOC:mah, GOC:tb, PMID:10390516] +synonym: "EOR-mediated activation of NF-kappaB " EXACT [GOC:dph, GOC:tb] +synonym: "EOR-mediated NF-kappaB activation" EXACT [] +synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity +relationship: part_of GO:0006983 ! ER overload response + +[Term] +id: GO:0006986 +name: response to unfolded protein +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] +comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. +subset: gosubset_prok +synonym: "heat shock protein activity" RELATED [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0051789 ! response to protein stimulus + +[Term] +id: GO:0006987 +name: activation of signaling protein activity involved in unfolded protein response +namespace: biological_process +def: "The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] +synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb] +synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT [] +synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT [] +is_a: GO:0032075 ! positive regulation of nuclease activity +is_a: GO:0045860 ! positive regulation of protein kinase activity +relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:0006988 +name: unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +consider: GO:0004521 +consider: GO:0030969 + +[Term] +id: GO:0006989 +name: unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +consider: GO:0008452 +consider: GO:0030969 + +[Term] +id: GO:0006990 +name: positive regulation of gene-specific transcription involved in unfolded protein response +namespace: biological_process +def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] +synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb] +synonym: "unfolded protein response, activation of target gene transcription" NARROW [] +synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb] +synonym: "unfolded protein response, stimulation of target gene transcription" NARROW [] +synonym: "unfolded protein response, target gene transcriptional activation" BROAD [] +synonym: "unfolded protein response, up regulation of target gene transcription" EXACT [] +synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT [] +synonym: "unfolded protein response, upregulation of target gene transcription" EXACT [] +is_a: GO:0043193 ! positive regulation of gene-specific transcription +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter +relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:0006991 +name: response to sterol depletion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0006992 +name: sterol depletion response, sterol regulatory element binding protein cleavage +namespace: biological_process +def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to depleted sterol levels." [GOC:bf, PMID:12923525] +synonym: "sterol depletion response, SREBP cleavage" EXACT [] +is_a: GO:0035103 ! sterol regulatory element binding protein cleavage +relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway + +[Term] +id: GO:0006993 +name: sterol depletion response, sterol regulatory element binding protein nuclear translocation +namespace: biological_process +def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus across the nuclear membrane, in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] +synonym: "sterol depletion response, SREBP nuclear translocation" EXACT [] +is_a: GO:0035105 ! sterol regulatory element binding protein nuclear translocation +relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway + +[Term] +id: GO:0006994 +name: positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response +namespace: biological_process +def: "The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] +synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0035104 ! positive regulation of transcription via sterol regulatory element binding +relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway + +[Term] +id: GO:0006995 +name: cellular response to nitrogen starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0043562 ! cellular response to nitrogen levels + +[Term] +id: GO:0006996 +name: organelle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "organelle organisation and biogenesis" EXACT [] +synonym: "organelle organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0006997 +name: nucleus organization +namespace: biological_process +alt_id: GO:0048287 +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +synonym: "nuclear morphology" RELATED [] +synonym: "nuclear organisation and biogenesis" EXACT [] +synonym: "nuclear organization" EXACT [] +synonym: "nuclear organization and biogenesis" EXACT [] +synonym: "nucleus organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0006998 +name: nuclear envelope organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] +synonym: "nuclear envelope organisation" EXACT [GOC:mah] +synonym: "nuclear envelope organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0006999 +name: nuclear pore organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jic, GOC:jl, GOC:mah] +synonym: "nuclear pore complex organization and biogenesis" EXACT [] +synonym: "nuclear pore organisation and biogenesis" EXACT [] +synonym: "nuclear pore organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0007000 +name: nucleolus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly the nucleolus." [GOC:dph, GOC:jic, GOC:jl, GOC:mah] +synonym: "nucleolus organisation and biogenesis" EXACT [] +synonym: "nucleolus organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0007002 +name: centromere binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0019237 + +[Term] +id: GO:0007003 +name: telomere binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0042162 + +[Term] +id: GO:0007004 +name: telomere maintenance via telomerase +namespace: biological_process +def: "The maintenace of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] +synonym: "telomerase-dependent telomere maintenance" EXACT [] +xref: Reactome:163090 +xref: Reactome:163096 +xref: Reactome:163099 +xref: Reactome:163120 +xref: Reactome:164616 +xref: Reactome:164617 +xref: Reactome:164620 +xref: Reactome:171319 +xref: Reactome:204681 +xref: Reactome:207368 +xref: Reactome:207812 +xref: Reactome:207815 +xref: Reactome:210720 +xref: Reactome:211317 +xref: Reactome:211638 +xref: Reactome:213765 +xref: Reactome:216960 +xref: Reactome:217340 +xref: Reactome:217343 +xref: Reactome:220611 +xref: Reactome:221126 +xref: Reactome:221410 +xref: Reactome:223502 +xref: Reactome:225815 +xref: Reactome:226015 +xref: Reactome:226016 +xref: Reactome:229293 +xref: Reactome:229780 +xref: Reactome:230045 +xref: Reactome:231985 +xref: Reactome:234484 +xref: Reactome:234714 +xref: Reactome:234717 +xref: Reactome:237268 +xref: Reactome:237781 +xref: Reactome:238063 +xref: Reactome:250481 +xref: Reactome:251276 +xref: Reactome:251340 +xref: Reactome:251341 +xref: Reactome:252051 +xref: Reactome:252274 +xref: Reactome:252403 +xref: Reactome:253320 +xref: Reactome:254353 +xref: Reactome:254423 +xref: Reactome:254433 +xref: Reactome:255254 +xref: Reactome:255428 +xref: Reactome:255561 +xref: Reactome:256500 +xref: Reactome:257473 +xref: Reactome:257575 +xref: Reactome:257585 +xref: Reactome:258550 +xref: Reactome:258778 +xref: Reactome:258935 +xref: Reactome:259951 +xref: Reactome:261147 +xref: Reactome:261239 +xref: Reactome:261249 +xref: Reactome:261963 +xref: Reactome:262182 +xref: Reactome:262309 +xref: Reactome:263242 +xref: Reactome:264067 +xref: Reactome:264128 +xref: Reactome:264129 +xref: Reactome:264762 +xref: Reactome:264997 +xref: Reactome:265160 +xref: Reactome:266139 +xref: Reactome:267091 +xref: Reactome:267162 +xref: Reactome:267163 +xref: Reactome:267939 +xref: Reactome:268129 +xref: Reactome:268286 +xref: Reactome:269901 +xref: Reactome:272146 +xref: Reactome:272282 +xref: Reactome:272292 +xref: Reactome:273491 +xref: Reactome:273780 +xref: Reactome:273967 +xref: Reactome:275803 +xref: Reactome:278135 +xref: Reactome:278288 +xref: Reactome:278298 +xref: Reactome:279958 +xref: Reactome:280233 +xref: Reactome:280446 +xref: Reactome:283872 +xref: Reactome:285016 +xref: Reactome:285107 +xref: Reactome:285117 +xref: Reactome:286058 +xref: Reactome:286303 +xref: Reactome:286468 +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0006278 ! RNA-dependent DNA replication + +[Term] +id: GO:0007005 +name: mitochondrion organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphology and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] +subset: goslim_generic +subset: goslim_pir +synonym: "mitochondria organization and biogenesis" EXACT [] +synonym: "mitochondrion organisation and biogenesis" EXACT [] +synonym: "mitochondrion organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007006 +name: mitochondrial membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "mitochondrial membrane organisation and biogenesis" EXACT [] +synonym: "mitochondrial membrane organization and biogenesis" EXACT [] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0007007 +name: inner mitochondrial membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +synonym: "inner mitochondrial membrane organisation and biogenesis" EXACT [] +synonym: "inner mitochondrial membrane organization and biogenesis" EXACT [] +synonym: "mitochondrial inner membrane organization" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization + +[Term] +id: GO:0007008 +name: outer mitochondrial membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. +synonym: "outer mitochondrial membrane organisation and biogenesis" EXACT [] +synonym: "outer mitochondrial membrane organization and biogenesis" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization + +[Term] +id: GO:0007009 +name: plasma membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] +subset: gosubset_prok +synonym: "plasma membrane organisation and biogenesis" EXACT [] +synonym: "plasma membrane organization and biogenesis" EXACT [] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0007010 +name: cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +subset: gosubset_prok +synonym: "cytoskeletal organization and biogenesis" EXACT [] +synonym: "cytoskeletal regulator activity" RELATED [] +synonym: "cytoskeleton organisation and biogenesis" EXACT [] +synonym: "cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007011 +name: regulation of cytoskeleton +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] +comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense. +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0007014 +name: indirect flight muscle actin ubiquitination +namespace: biological_process +is_a: GO:0016567 ! protein ubiquitination +is_a: GO:0030047 ! actin modification + +[Term] +id: GO:0007015 +name: actin filament organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] +synonym: "actin filament organisation" EXACT [] +synonym: "regulation of actin filament localization" NARROW [] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0007016 +name: cytoskeletal anchoring at plasma membrane +namespace: biological_process +def: "Process by which cytoskeletal filaments are directly or indirectly linked to the plasma membrane." [ISBN:0198599323] +synonym: "cytoskeletal anchoring activity" RELATED [] +is_a: GO:0007010 ! cytoskeleton organization +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0007017 +name: microtubule-based process +namespace: biological_process +def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007018 +name: microtubule-based movement +namespace: biological_process +def: "Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [ISBN:0815316194] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport + +[Term] +id: GO:0007019 +name: microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] +synonym: "microtubule depolymerization during nuclear congression" NARROW [] +synonym: "microtubule disassembly" EXACT [] +is_a: GO:0031109 ! microtubule polymerization or depolymerization +is_a: GO:0051261 ! protein depolymerization + +[Term] +id: GO:0007020 +name: microtubule nucleation +namespace: biological_process +def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [ISBN:0815316194] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0007021 +name: tubulin complex assembly +namespace: biological_process +def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] +synonym: "tubulin assembly" EXACT [] +synonym: "tubulin folding" RELATED [] +synonym: "tubulin-specific chaperone activity" RELATED [] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0007022 +name: chaperonin-mediated tubulin folding +namespace: biological_process +def: "Partial folding of alpha- or beta-tubulin into a non-native folding intermediate, mediated by cytosolic chaperonin CCT." [PMID:10542094] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0007023 +name: post-chaperonin tubulin folding pathway +namespace: biological_process +def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0007024 +name: alpha-tubulin folding +namespace: biological_process +def: "Folding of the microtubule constituent protein alpha-tubulin." [GOC:mah] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0007025 +name: beta-tubulin folding +namespace: biological_process +def: "Folding of the microtubule constituent protein beta-tubulin." [GOC:mah] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0007026 +name: negative regulation of microtubule depolymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] +synonym: "down regulation of microtubule depolymerization" EXACT [] +synonym: "down-regulation of microtubule depolymerization" EXACT [] +synonym: "downregulation of microtubule depolymerization" EXACT [] +synonym: "inhibition of microtubule depolymerization" NARROW [] +synonym: "microtubule stabilization" EXACT [] +synonym: "negative regulation of microtubule disassembly" EXACT [] +is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization +is_a: GO:0031114 ! regulation of microtubule depolymerization +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0043242 ! negative regulation of protein complex disassembly +relationship: negatively_regulates GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0007027 +name: negative regulation of microtubule depolymerization in axoneme +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] +synonym: "axonemal microtubule stabilization" EXACT [] +synonym: "negative regulation of axonemal microtubule depolymerization" RELATED [GOC:dph] +is_a: GO:0007026 ! negative regulation of microtubule depolymerization + +[Term] +id: GO:0007028 +name: cytoplasm organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +synonym: "cytoplasm organisation and biogenesis" EXACT [] +synonym: "cytoplasm organization and biogenesis" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0007029 +name: endoplasmic reticulum organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "endoplasmic reticulum morphology" RELATED [] +synonym: "endoplasmic reticulum organisation and biogenesis" EXACT [] +synonym: "endoplasmic reticulum organization and biogenesis" EXACT [] +synonym: "ER organisation and biogenesis" EXACT [] +synonym: "ER organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007030 +name: Golgi organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "Golgi organisation and biogenesis" EXACT [] +synonym: "Golgi organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007031 +name: peroxisome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] +subset: goslim_pir +synonym: "peroxisome organisation and biogenesis" EXACT [] +synonym: "peroxisome organization and biogenesis" EXACT [] +synonym: "peroxisome-assembly ATPase activity" RELATED [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007032 +name: endosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "endosome organisation and biogenesis" EXACT [] +synonym: "endosome organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007033 +name: vacuole organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] +subset: goslim_pir +synonym: "vacuolar assembly" EXACT [] +synonym: "vacuole organisation and biogenesis" EXACT [] +synonym: "vacuole organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007034 +name: vacuolar transport +namespace: biological_process +def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0007035 +name: vacuolar acidification +namespace: biological_process +def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jic] +is_a: GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0007036 +name: vacuolar calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0007037 +name: vacuolar phosphate transport +namespace: biological_process +def: "The directed movement of phosphates into, out of or within a vacuole." [GOC:ai] +is_a: GO:0006817 ! phosphate transport +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0007038 +name: endocytosed protein transport to vacuole +namespace: biological_process +def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai] +comment: See also the biological process term 'endocytosis ; GO:0006897'. +synonym: "delivery of endocytosed proteins to the vacuole" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0007039 +name: vacuolar protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah] +synonym: "vacuolar protein breakdown" EXACT [] +synonym: "vacuolar protein catabolism" EXACT [] +synonym: "vacuolar protein degradation" EXACT [] +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0007040 +name: lysosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] +synonym: "lysosome organisation and biogenesis" EXACT [] +synonym: "lysosome organization and biogenesis" EXACT [] +is_a: GO:0007033 ! vacuole organization + +[Term] +id: GO:0007041 +name: lysosomal transport +namespace: biological_process +def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0007042 +name: lysosomal lumen acidification +namespace: biological_process +def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jic] +is_a: GO:0051452 ! intracellular pH reduction +relationship: part_of GO:0007040 ! lysosome organization + +[Term] +id: GO:0007043 +name: cell-cell junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] +synonym: "intercellular junction assembly" EXACT [] +is_a: GO:0006461 ! protein complex assembly +is_a: GO:0034329 ! cell junction assembly +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0007044 +name: cell-substrate junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] +is_a: GO:0034329 ! cell junction assembly + +[Term] +id: GO:0007045 +name: hemi-adherens junction assembly +namespace: biological_process +def: "The formation of a hemi-adherens junction. Within proximal sheath cells, actin/myosin bundles are anchored to the plasma membrane at plaque-like structures termed hemi-adherens junctions, which in turn are closely associated with the gonadal basal lamina. It is proposed that hemi-adherens junctions function to anchor the myofilament apparatus within the basal plasma membrane of the sheath cell and to the exterior basal lamina." [PMID:10419689] +is_a: GO:0007044 ! cell-substrate junction assembly + +[Term] +id: GO:0007047 +name: cell wall organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "cell wall organisation and biogenesis" EXACT [] +synonym: "cell wall organization and biogenesis" EXACT [] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0007048 +name: oncogenesis +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a pathological process. +is_obsolete: true + +[Term] +id: GO:0007049 +name: cell cycle +namespace: biological_process +def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "cell-division cycle" EXACT [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007050 +name: cell cycle arrest +namespace: biological_process +def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] +synonym: "arrest of cell cycle progression" EXACT [] +synonym: "cessation of cell cycle" EXACT [] +synonym: "termination of cell cycle" EXACT [] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0007051 +name: spindle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] +synonym: "spindle organisation and biogenesis" EXACT [] +synonym: "spindle organization and biogenesis" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0007052 +name: mitotic spindle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] +synonym: "mitotic spindle organisation and biogenesis" EXACT [] +synonym: "mitotic spindle organization and biogenesis" EXACT [] +synonym: "spindle organization and biogenesis during mitosis" EXACT [] +is_a: GO:0007051 ! spindle organization +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0007053 +name: spindle assembly involved in male meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] +synonym: "male meiotic spindle assembly (sensu Metazoa)" RELATED [] +is_a: GO:0051225 ! spindle assembly +relationship: part_of GO:0007140 ! male meiosis + +[Term] +id: GO:0007054 +name: spindle assembly involved in male meiosis I +namespace: biological_process +def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] +synonym: "male meiosis I spindle assembly (sensu Metazoa)" RELATED [] +is_a: GO:0007053 ! spindle assembly involved in male meiosis +relationship: part_of GO:0007141 ! male meiosis I + +[Term] +id: GO:0007055 +name: spindle assembly involved male meiosis II +namespace: biological_process +def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] +synonym: "male meiosis II spindle assembly (sensu Metazoa)" RELATED [] +is_a: GO:0007053 ! spindle assembly involved in male meiosis +relationship: part_of GO:0007142 ! male meiosis II + +[Term] +id: GO:0007056 +name: spindle assembly involved in female meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] +synonym: "female meiotic spindle assembly (sensu Metazoa)" RELATED [] +is_a: GO:0051225 ! spindle assembly +relationship: part_of GO:0007143 ! female meiosis + +[Term] +id: GO:0007057 +name: spindle assembly involved in female meiosis I +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] +synonym: "female meiosis I spindle assembly (sensu Metazoa)" RELATED [] +is_a: GO:0007056 ! spindle assembly involved in female meiosis +relationship: part_of GO:0007144 ! female meiosis I + +[Term] +id: GO:0007058 +name: spindle assembly involved in female meiosis II +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. As in, but not restricted to, the multicellular animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:mah] +synonym: "female meiosis II spindle assembly (sensu Metazoa)" RELATED [] +is_a: GO:0007056 ! spindle assembly involved in female meiosis +relationship: part_of GO:0007147 ! female meiosis II + +[Term] +id: GO:0007059 +name: chromosome segregation +namespace: biological_process +def: "The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "chromosome division" EXACT [] +synonym: "chromosome transmission" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007060 +name: male meiosis chromosome segregation +namespace: biological_process +def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0045132 ! meiotic chromosome segregation +relationship: part_of GO:0007140 ! male meiosis + +[Term] +id: GO:0007062 +name: sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process by which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome." [GOC:mah, ISBN:0815316194] +xref: Reactome:163048 +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0007063 +name: regulation of sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: regulates GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0007064 +name: mitotic sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] +is_a: GO:0007062 ! sister chromatid cohesion +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007065 +name: male meiosis sister chromatid cohesion +namespace: biological_process +def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007140 ! male meiosis + +[Term] +id: GO:0007066 +name: female meiosis sister chromatid cohesion +namespace: biological_process +def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007143 ! female meiosis + +[Term] +id: GO:0007067 +name: mitosis +namespace: biological_process +def: "Progression through mitosis, the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:ma, ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000087 ! M phase of mitotic cell cycle + +[Term] +id: GO:0007068 +name: negative regulation of transcription, mitotic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] +synonym: "down regulation of transcription, mitotic" EXACT [] +synonym: "down-regulation of transcription, mitotic" EXACT [] +synonym: "downregulation of transcription, mitotic" EXACT [] +synonym: "inhibition of transcription, mitotic" NARROW [] +synonym: "mitotic repression of transcription" EXACT [] +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +is_a: GO:0045896 ! regulation of transcription, mitotic + +[Term] +id: GO:0007069 +name: negative regulation of transcription from RNA polymerase I promoter, mitotic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] +synonym: "downregulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] +synonym: "inhibition of transcription from RNA polymerase I promoter, mitotic" NARROW [] +synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] +synonym: "negative regulation of transcription from Pol I promoter, mitotic" EXACT [] +is_a: GO:0007068 ! negative regulation of transcription, mitotic +is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter +is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic + +[Term] +id: GO:0007070 +name: negative regulation of transcription from RNA polymerase II promoter, mitotic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter, mitotic" NARROW [] +synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] +synonym: "negative regulation of transcription from Pol II promoter, mitotic" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0007068 ! negative regulation of transcription, mitotic +is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic + +[Term] +id: GO:0007071 +name: negative regulation of transcription from RNA polymerase III promoter, mitotic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] +synonym: "downregulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] +synonym: "inhibition of transcription from RNA polymerase III promoter, mitotic" NARROW [] +synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] +synonym: "negative regulation of transcription from Pol III promoter, mitotic" EXACT [] +is_a: GO:0007068 ! negative regulation of transcription, mitotic +is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter +is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic + +[Term] +id: GO:0007072 +name: positive regulation of transcription on exit from mitosis +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0045941 ! positive regulation of transcription +relationship: part_of GO:0010458 ! exit from mitosis + +[Term] +id: GO:0007073 +name: positive regulation of transcription on exit from mitosis, from RNA polymerase I promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] +is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis + +[Term] +id: GO:0007074 +name: positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] +synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] +is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis + +[Term] +id: GO:0007075 +name: positive regulation of transcription on exit from mitosis, from RNA polymerase III promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] +synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] +is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis + +[Term] +id: GO:0007076 +name: mitotic chromosome condensation +namespace: biological_process +def: "The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0030261 ! chromosome condensation +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007077 +name: mitotic nuclear envelope disassembly +namespace: biological_process +def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf] +synonym: "mitotic nuclear envelope breakdown" EXACT [] +synonym: "mitotic nuclear envelope catabolism" EXACT [] +synonym: "mitotic nuclear envelope degradation" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051081 ! nuclear envelope disassembly +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0007078 +name: lamin depolymerization +namespace: biological_process +def: "The cell cycle process whereby lamin is depolymerized." [GOC:jic] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051261 ! protein depolymerization +relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly + +[Term] +id: GO:0007079 +name: mitotic chromosome movement towards spindle pole +namespace: biological_process +alt_id: GO:0007082 +def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] +synonym: "chromosome migration to spindle pole during mitosis" EXACT [] +synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] +synonym: "mitotic chromosome movement" BROAD [] +synonym: "mitotic chromosome movement to spindle pole" EXACT [] +synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] +synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051305 ! chromosome movement towards spindle pole +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007080 +name: mitotic metaphase plate congression +namespace: biological_process +def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051310 ! metaphase plate congression +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007081 +name: mitotic sister-chromatid adhesion release +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes. +is_obsolete: true +consider: GO:0000070 +consider: GO:0007064 + +[Term] +id: GO:0007083 +name: mitotic chromosome decondensation +namespace: biological_process +def: "The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051312 ! chromosome decondensation +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007084 +name: mitotic nuclear envelope reassembly +namespace: biological_process +def: "The cell cycle process whereby the nuclear envelope reforms during mitotic cell division." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031468 ! nuclear envelope reassembly +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0007085 +name: nuclear membrane vesicle binding to chromatin +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +consider: GO:0003682 + +[Term] +id: GO:0007086 +name: vesicle fusion with nuclear membrane +namespace: biological_process +def: "The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs." [GOC:jic] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly + +[Term] +id: GO:0007087 +name: mitotic nuclear pore complex reassembly +namespace: biological_process +def: "The cell cycle process whereby nuclear pore complexes reform during mitotic cell division." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051292 ! nuclear pore complex assembly +relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly + +[Term] +id: GO:0007088 +name: regulation of mitosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0007067 ! mitosis + +[Term] +id: GO:0007089 +name: traversing start control point of mitotic cell cycle +namespace: biological_process +alt_id: GO:0000081 +def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194] +synonym: "G1 checkpoint" RELATED [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle + +[Term] +id: GO:0007090 +name: regulation of S phase of mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0033261 ! regulation of S phase +relationship: regulates GO:0000084 ! S phase of mitotic cell cycle + +[Term] +id: GO:0007091 +name: mitotic metaphase/anaphase transition +namespace: biological_process +def: "The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783] +xref: Reactome:211778 +xref: Reactome:221543 +xref: Reactome:230154 +xref: Reactome:238183 +xref: Reactome:68881 +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0007092 +name: activation of anaphase-promoting complex during mitotic cell cycle +namespace: biological_process +def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] +synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT [] +synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT [] +synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT [] +synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT [] +synonym: "anaphase-promoting complex activation during mitotic cell cycle" EXACT [] +synonym: "APC activation during mitotic cell cycle" EXACT [] +synonym: "mitotic anaphase promoting complex activation" EXACT [] +synonym: "mitotic anaphase promoting complex activator" NARROW [] +synonym: "mitotic anaphase-promoting complex activation" EXACT [] +synonym: "mitotic anaphase-promoting complex activator" NARROW [] +synonym: "mitotic APC activation" EXACT [] +synonym: "mitotic APC activator" NARROW [] +xref: Reactome:162659 +xref: Reactome:163010 +xref: Reactome:204411 +xref: Reactome:207643 +xref: Reactome:213411 +xref: Reactome:217136 +xref: Reactome:223197 +xref: Reactome:225891 +xref: Reactome:231660 +xref: Reactome:234574 +xref: Reactome:239612 +xref: Reactome:245838 +xref: Reactome:250346 +xref: Reactome:253161 +xref: Reactome:256356 +xref: Reactome:259780 +xref: Reactome:265942 +xref: Reactome:283716 +is_a: GO:0051437 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle +is_a: GO:0051488 ! activation of anaphase-promoting complex +relationship: part_of GO:0030071 ! regulation of mitotic metaphase/anaphase transition +relationship: part_of GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0007093 +name: mitotic cell cycle checkpoint +namespace: biological_process +def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, GOC:rn, PMID:12360190] +synonym: "mitotic checkpoint" RELATED [] +is_a: GO:0000075 ! cell cycle checkpoint +is_a: GO:0007346 ! regulation of mitotic cell cycle + +[Term] +id: GO:0007094 +name: mitotic cell cycle spindle assembly checkpoint +namespace: biological_process +def: "A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:rn, PMID:12360190] +synonym: "Mad2-dependent checkpoint" NARROW [] +synonym: "mitotic spindle checkpoint" RELATED [] +xref: Reactome:212060 +xref: Reactome:221823 +xref: Reactome:230392 +xref: Reactome:238432 +xref: Reactome:244975 +xref: Reactome:252583 +xref: Reactome:255764 +xref: Reactome:259160 +xref: Reactome:262517 +xref: Reactome:265345 +xref: Reactome:268471 +xref: Reactome:274195 +xref: Reactome:280667 +xref: Reactome:286686 +xref: Reactome:69618 +is_a: GO:0007093 ! mitotic cell cycle checkpoint +is_a: GO:0031577 ! spindle checkpoint + +[Term] +id: GO:0007095 +name: mitotic cell cycle G2/M transition DNA damage checkpoint +namespace: biological_process +def: "A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA." [GOC:mah, PMID:10856933, PMID:11406266] +synonym: "mitotic G2 checkpoint" RELATED [] +is_a: GO:0031572 ! G2/M transition DNA damage checkpoint + +[Term] +id: GO:0007096 +name: regulation of exit from mitosis +namespace: biological_process +def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] +is_a: GO:0007088 ! regulation of mitosis +relationship: regulates GO:0010458 ! exit from mitosis + +[Term] +id: GO:0007097 +name: nuclear migration +namespace: biological_process +def: "The directed movement of the nucleus." [GOC:ai] +synonym: "nucleus migration" EXACT [] +is_a: GO:0040023 ! establishment of nucleus localization + +[Term] +id: GO:0007098 +name: centrosome cycle +namespace: biological_process +def: "The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051297 ! centrosome organization + +[Term] +id: GO:0007099 +name: centriole replication +namespace: biological_process +def: "The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] +synonym: "centriole duplication" EXACT [] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051298 ! centrosome duplication + +[Term] +id: GO:0007100 +name: mitotic centrosome separation +namespace: biological_process +def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] +is_a: GO:0051299 ! centrosome separation + +[Term] +id: GO:0007101 +name: male meiosis centrosome cycle +namespace: biological_process +def: "Centrosome duplication and separation in the context of male meiosis." [GOC:mah] +is_a: GO:0007098 ! centrosome cycle + +[Term] +id: GO:0007103 +name: spindle pole body duplication in nuclear envelope +namespace: biological_process +def: "Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence." [ISBN:0879693649] +synonym: "spindle pole body duplication (sensu Saccharomyces)" EXACT [] +is_a: GO:0030474 ! spindle pole body duplication + +[Term] +id: GO:0007105 +name: cytokinesis, site selection +namespace: biological_process +def: "The process of marking the place where cytokinesis will occur." [GOC:clt, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "actomyosin ring positioning" NARROW [] +synonym: "contractile ring positioning" NARROW [] +synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0007106 +name: cytokinesis, protein recruitment +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was not defined. +is_obsolete: true + +[Term] +id: GO:0007107 +name: membrane addition at site of cytokinesis +namespace: biological_process +def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt] +synonym: "cytokinesis, membrane recruitment/generation" EXACT [] +is_a: GO:0016044 ! membrane organization +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0007108 +name: cytokinesis, initiation of separation +namespace: biological_process +def: "The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb] +synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000920 ! cell separation during cytokinesis + +[Term] +id: GO:0007109 +name: cytokinesis, completion of separation +namespace: biological_process +def: "The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb] +synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000920 ! cell separation during cytokinesis + +[Term] +id: GO:0007110 +name: cytokinesis after meiosis I +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai] +is_a: GO:0033206 ! cytokinesis after meiosis + +[Term] +id: GO:0007111 +name: cytokinesis after meiosis II +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai] +is_a: GO:0033206 ! cytokinesis after meiosis + +[Term] +id: GO:0007112 +name: male meiosis cytokinesis +namespace: biological_process +def: "A cell cycle process that occurs during male meiosis and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] +is_a: GO:0033206 ! cytokinesis after meiosis + +[Term] +id: GO:0007113 +name: endomitotic cell cycle +namespace: biological_process +def: "A cell cycle in which chromosomes are replicated and sister chromatids separate, but neither spindle formation nor nuclear membrane breakdown, and nuclear division does not occur, resulting in an increased number of chromosomes in the cell." [GOC:expert_vm, http://www.onelook.com] +synonym: "endomitosis" EXACT [] +is_a: GO:0007049 ! cell cycle + +[Term] +id: GO:0007114 +name: cell budding +namespace: biological_process +def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_yeast +subset: gosubset_prok +synonym: "budding" BROAD [] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0032505 ! reproduction of a single-celled organism + +[Term] +id: GO:0007115 +name: bud site selection/establishment of cell polarity (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents two concepts. +is_obsolete: true +consider: GO:0000282 +consider: GO:0030010 + +[Term] +id: GO:0007116 +name: regulation of cell budding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah] +synonym: "regulation of budding" BROAD [] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0007114 ! cell budding + +[Term] +id: GO:0007117 +name: budding cell bud growth +namespace: biological_process +def: "The process by which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators] +synonym: "bud growth" BROAD [] +is_a: GO:0022413 ! reproductive process in single-celled organism +is_a: GO:0048590 ! non-developmental growth +relationship: part_of GO:0007114 ! cell budding + +[Term] +id: GO:0007118 +name: budding cell apical bud growth +namespace: biological_process +def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators] +synonym: "apical bud growth" BROAD [] +is_a: GO:0007117 ! budding cell bud growth + +[Term] +id: GO:0007119 +name: budding cell isotropic bud growth +namespace: biological_process +def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators] +synonym: "isotropic bud growth" BROAD [] +is_a: GO:0007117 ! budding cell bud growth + +[Term] +id: GO:0007120 +name: axial cellular bud site selection +namespace: biological_process +def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt] +synonym: "axial bud site selection" EXACT [] +synonym: "axial budding" BROAD [] +is_a: GO:0000282 ! cellular bud site selection +is_a: GO:0007114 ! cell budding + +[Term] +id: GO:0007121 +name: bipolar cellular bud site selection +namespace: biological_process +def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt] +synonym: "bipolar bud site selection" EXACT [] +synonym: "bipolar budding" BROAD [] +synonym: "polar budding" BROAD [] +is_a: GO:0000282 ! cellular bud site selection +is_a: GO:0007114 ! cell budding + +[Term] +id: GO:0007122 +name: loss of asymmetric budding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is a phenotype rather than a biological process. +is_obsolete: true +consider: GO:0006033 + +[Term] +id: GO:0007123 +name: bud scar accumulation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is a phenotype rather than a biological process. +is_obsolete: true +consider: GO:0000282 + +[Term] +id: GO:0007124 +name: pseudohyphal growth +namespace: biological_process +def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] +subset: goslim_candida +subset: goslim_yeast +is_a: GO:0016049 ! cell growth +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0007125 +name: invasive growth +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it has been split into two new terms. +is_obsolete: true +consider: GO:0001403 +consider: GO:0044409 +consider: GO:0044412 + +[Term] +id: GO:0007126 +name: meiosis +namespace: biological_process +def: "Progression through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [PMID:9334324] +subset: goslim_yeast +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051327 ! M phase of meiotic cell cycle + +[Term] +id: GO:0007127 +name: meiosis I +namespace: biological_process +def: "Progression through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [PMID:9334324] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007126 ! meiosis + +[Term] +id: GO:0007128 +name: meiotic prophase I +namespace: biological_process +def: "Progression through prophase of meiosis I; divided into several stages." [GOC:mah] +is_a: GO:0051324 ! prophase +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007129 +name: synapsis +namespace: biological_process +def: "The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh] +synonym: "homologous chromosome pairing at meiosis" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007130 +name: synaptonemal complex assembly +namespace: biological_process +def: "The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "synaptonemal complex formation" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0007129 ! synapsis + +[Term] +id: GO:0007131 +name: reciprocal meiotic recombination +namespace: biological_process +alt_id: GO:0000021 +alt_id: GO:0007145 +def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] +synonym: "female meiotic recombination" NARROW [] +synonym: "gene conversion with reciprocal crossover" EXACT [] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007132 +name: meiotic metaphase I +namespace: biological_process +def: "Progression through metaphase of meiosis I; analogous to mitotic metaphase." [GOC:mah] +is_a: GO:0051323 ! metaphase +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007133 +name: meiotic anaphase I +namespace: biological_process +def: "Progression through anaphase of meiosis I; analogous to mitotic anaphase." [GOC:mah] +is_a: GO:0051322 ! anaphase +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007134 +name: meiotic telophase I +namespace: biological_process +def: "Progression through telophase of meiosis I; analogous to mitotic telophase." [GOC:mah] +is_a: GO:0051326 ! telophase +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007135 +name: meiosis II +namespace: biological_process +def: "Progression through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [ISBN:0198547684] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007126 ! meiosis + +[Term] +id: GO:0007136 +name: meiotic prophase II +namespace: biological_process +def: "Progression through prophase of meiosis II; analogous to mitotic prophase." [GOC:mah] +is_a: GO:0051324 ! prophase +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0007137 +name: meiotic metaphase II +namespace: biological_process +def: "Progression through metaphase of meiosis II; analogous to mitotic metaphase." [GOC:mah] +is_a: GO:0051323 ! metaphase +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0007138 +name: meiotic anaphase II +namespace: biological_process +def: "Progression through anaphase of meiosis II; analogous to mitotic anaphase." [GOC:mah] +is_a: GO:0051322 ! anaphase +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0007139 +name: meiotic telophase II +namespace: biological_process +def: "Progression through telophase of meiosis II; analogous to mitotic telophase." [GOC:mah] +is_a: GO:0051326 ! telophase +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0007140 +name: male meiosis +namespace: biological_process +def: "Progression through the nuclear division phase of a meiotic cell cycle in the male germline." [GOC:mah] +is_a: GO:0007126 ! meiosis + +[Term] +id: GO:0007141 +name: male meiosis I +namespace: biological_process +def: "Progression through male meiosis I, the first meiotic division in the male germline." [GOC:mah] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007140 ! male meiosis + +[Term] +id: GO:0007142 +name: male meiosis II +namespace: biological_process +def: "Progression through male meiosis II, the second meiotic division in the male germline." [GOC:mah] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0007140 ! male meiosis + +[Term] +id: GO:0007143 +name: female meiosis +namespace: biological_process +def: "Progression through the nuclear division phase of a meiotic cell cycle in the female germline." [GOC:ems, GOC:mah] +comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'. +is_a: GO:0007126 ! meiosis + +[Term] +id: GO:0007144 +name: female meiosis I +namespace: biological_process +def: "The cell cycle process whereby the first meiotic division occurs in the female germline." [GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007143 ! female meiosis + +[Term] +id: GO:0007146 +name: meiotic recombination nodule assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] +is_a: GO:0000707 ! meiotic DNA recombinase assembly + +[Term] +id: GO:0007147 +name: female meiosis II +namespace: biological_process +def: "The cell cycle process whereby the second meiotic division occurs in the female germline." [GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007143 ! female meiosis + +[Term] +id: GO:0007149 +name: colony morphology +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it describes a phenotype rather than a biological goal. +is_obsolete: true + +[Term] +id: GO:0007150 +name: growth pattern +namespace: biological_process +def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jic] +comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process. +is_obsolete: true +consider: GO:0040007 + +[Term] +id: GO:0007154 +name: cell communication +namespace: biological_process +def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007155 +name: cell adhesion +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] +subset: goslim_candida +subset: goslim_pir +subset: gosubset_prok +synonym: "cell adhesion molecule activity" RELATED [] +is_a: GO:0009987 ! cellular process +is_a: GO:0022610 ! biological adhesion + +[Term] +id: GO:0007156 +name: homophilic cell adhesion +namespace: biological_process +def: "The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0007157 +name: heterophilic cell adhesion +namespace: biological_process +def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0007158 +name: neuron adhesion +namespace: biological_process +def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators] +synonym: "neuronal cell adhesion" EXACT [] +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0007159 +name: leukocyte adhesion +namespace: biological_process +def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] +synonym: "leukocyte cell adhesion" EXACT [] +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0007160 +name: cell-matrix adhesion +namespace: biological_process +def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] +subset: gosubset_prok +is_a: GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0007161 +name: calcium-independent cell-matrix adhesion +namespace: biological_process +def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] +synonym: "calcium-independent cell adhesion molecule activity" RELATED [] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0007162 +name: negative regulation of cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] +synonym: "cell adhesion receptor inhibitor activity" RELATED [] +synonym: "down regulation of cell adhesion" EXACT [] +synonym: "down-regulation of cell adhesion" EXACT [] +synonym: "downregulation of cell adhesion" EXACT [] +synonym: "inhibition of cell adhesion" NARROW [] +is_a: GO:0030155 ! regulation of cell adhesion +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0007155 ! cell adhesion + +[Term] +id: GO:0007163 +name: establishment or maintenance of cell polarity +namespace: biological_process +alt_id: GO:0030012 +alt_id: GO:0030467 +def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +synonym: "establishment and/or maintenance of cell polarity (sensu Fungi)" NARROW [] +synonym: "establishment and/or maintenance of cell polarity (sensu Saccharomyces)" NARROW [] +synonym: "establishment and/or maintenance of cell polarization" EXACT [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0007164 +name: establishment of tissue polarity +namespace: biological_process +def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0007165 +name: signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell." [GOC:go_curators] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "signaling" EXACT [] +synonym: "signaling cascade" EXACT [] +synonym: "signalling" EXACT [] +synonym: "signalling cascade" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0007166 +name: cell surface receptor linked signal transduction +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell." [GOC:mah] +subset: gosubset_prok +xref: Reactome:110437 +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0007167 +name: enzyme linked receptor protein signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase." [GOC:mah, ISBN:0185316194] +synonym: "enzyme linked receptor protein signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007168 +name: receptor guanylyl cyclase signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity." [GOC:mah] +synonym: "receptor guanylyl cyclase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007169 +name: transmembrane receptor protein tyrosine kinase signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:ceb] +synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007170 +name: transmembrane receptor protein tyrosine kinase ligand binding +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +consider: GO:0030971 + +[Term] +id: GO:0007171 +name: activation of transmembrane receptor protein tyrosine kinase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] +synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] +synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] +is_a: GO:0032147 ! activation of protein kinase activity +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0007172 +name: signal complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors." [PMID:9646862] +synonym: "signal complex formation" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0007173 +name: epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "EGF receptor signaling pathway" EXACT [] +synonym: "EGF receptor signalling pathway" EXACT [] +synonym: "EGFR signaling pathway" EXACT [] +synonym: "epidermal growth factor receptor signalling pathway" EXACT [] +xref: Reactome:177929 +xref: Reactome:211781 +xref: Reactome:221546 +xref: Reactome:230157 +xref: Reactome:238186 +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0007174 +name: epidermal growth factor ligand processing +namespace: biological_process +def: "The proteolysis of epidermal growth factor after its internalization via binding to its receptor." [GOC:isa_complete, PMID:2985587] +synonym: "EGF receptor ligand processing" EXACT [] +is_a: GO:0006508 ! proteolysis +relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0007175 +name: negative regulation of epidermal growth factor receptor activity +namespace: biological_process +alt_id: GO:0007177 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity." [GOC:go_curators] +synonym: "down regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "down-regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "downregulation of epidermal growth factor receptor activity" EXACT [] +synonym: "EGF receptor downregulation" EXACT [] +synonym: "inhibition of epidermal growth factor receptor activity" NARROW [] +synonym: "negative regulation of EGF receptor activity" EXACT [] +synonym: "negative regulation of EGFR activity" EXACT [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity +is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0007176 +name: regulation of epidermal growth factor receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of EGF receptor activity." [GOC:dph, GOC:go_curators] +synonym: "regulation of EGF receptor activity" EXACT [] +synonym: "regulation of EGFR activity" EXACT [] +is_a: GO:0010469 ! regulation of receptor activity +is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0007178 +name: transmembrane receptor protein serine/threonine kinase signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:mah] +synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007179 +name: transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "TGF-beta receptor signaling pathway" EXACT [] +synonym: "TGF-beta receptor signalling pathway" EXACT [] +synonym: "TGFbeta receptor signaling pathway" EXACT [] +synonym: "TGFbeta receptor signalling pathway" EXACT [] +synonym: "transforming growth factor beta receptor signalling pathway" EXACT [] +xref: Reactome:170834 +xref: Reactome:211602 +xref: Reactome:221377 +xref: Reactome:230015 +xref: Reactome:238033 +xref: Reactome:244845 +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0007180 +name: transforming growth factor beta ligand binding to type II receptor +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a function. +synonym: "TGF-beta ligand binding to type II receptor" EXACT [] +synonym: "TGFbeta ligand binding to type II receptor" EXACT [] +is_obsolete: true +consider: GO:0005026 +consider: GO:0005160 +consider: GO:0050431 + +[Term] +id: GO:0007181 +name: transforming growth factor beta receptor complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, http://en.wikipedia.org/wiki/TGF_beta_signaling_pathway, Reactome:REACT_7425] +synonym: "TGF-beta receptor complex assembly" EXACT [] +synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT [] +synonym: "TGFbeta receptor complex assembly" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0007182 +name: common-partner SMAD protein phosphorylation +namespace: biological_process +is_a: GO:0006468 ! protein amino acid phosphorylation +relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0007183 +name: SMAD protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete] +synonym: "SMAD protein heteromerization" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0007184 +name: SMAD protein nuclear translocation +namespace: biological_process +is_a: GO:0000060 ! protein import into nucleus, translocation +relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0007185 +name: transmembrane receptor protein tyrosine phosphatase signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand." [GOC:mah] +synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007186 +name: G-protein coupled receptor protein signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] +synonym: "G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "G-protein coupled receptor protein signal transduction" EXACT [] +synonym: "G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "G-protein-coupled receptor protein signaling pathway" EXACT [] +synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "GPCR protein signaling pathway" EXACT [] +synonym: "GPCR protein signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007187 +name: G-protein signaling, coupled to cyclic nucleotide second messenger +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, ISBN:0815316194] +synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] +synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway +is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling + +[Term] +id: GO:0007188 +name: G-protein signaling, coupled to cAMP nucleotide second messenger +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP." [GOC:mah, ISBN:0815316194] +synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT [] +synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] +synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger +is_a: GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0007189 +name: G-protein signaling, adenylate cyclase activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:mah, ISBN:0815316194] +synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT [] +synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT [] +synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT [] +synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT [] +synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT [] +synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT [] +synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT [] +is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger +is_a: GO:0045762 ! positive regulation of adenylate cyclase activity + +[Term] +id: GO:0007190 +name: activation of adenylate cyclase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai] +synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb] +synonym: "adenylate cyclase activator" RELATED [] +synonym: "adenylyl cyclase activation" EXACT [] +is_a: GO:0045762 ! positive regulation of adenylate cyclase activity + +[Term] +id: GO:0007191 +name: dopamine receptor, adenylate cyclase activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:mah] +synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT [] +is_a: GO:0007189 ! G-protein signaling, adenylate cyclase activating pathway +is_a: GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0007192 +name: serotonin receptor, adenylate cyclase activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:mah] +synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT [] +is_a: GO:0007189 ! G-protein signaling, adenylate cyclase activating pathway + +[Term] +id: GO:0007193 +name: G-protein signaling, adenylate cyclase inhibiting pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:mah, ISBN:0815316194] +synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT [] +synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT [] +synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT [] +synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger +is_a: GO:0007194 ! negative regulation of adenylate cyclase activity + +[Term] +id: GO:0007194 +name: negative regulation of adenylate cyclase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] +synonym: "adenylate cyclase inhibitor" RELATED [] +synonym: "down regulation of adenylate cyclase activity" EXACT [] +synonym: "down-regulation of adenylate cyclase activity" EXACT [] +synonym: "downregulation of adenylate cyclase activity" EXACT [] +synonym: "inhibition of adenylate cyclase activity" NARROW [] +synonym: "negative regulation of adenylyl cyclase activity" EXACT [] +is_a: GO:0031280 ! negative regulation of cyclase activity +is_a: GO:0045761 ! regulation of adenylate cyclase activity +is_a: GO:0051350 ! negative regulation of lyase activity + +[Term] +id: GO:0007195 +name: dopamine receptor, adenylate cyclase inhibiting pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:mah] +synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007193 ! G-protein signaling, adenylate cyclase inhibiting pathway +is_a: GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0007196 +name: metabotropic glutamate receptor, adenylate cyclase inhibiting pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:mah] +synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007193 ! G-protein signaling, adenylate cyclase inhibiting pathway +is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway + +[Term] +id: GO:0007197 +name: muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:mah] +synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007193 ! G-protein signaling, adenylate cyclase inhibiting pathway + +[Term] +id: GO:0007198 +name: serotonin receptor, adenylate cyclase inhibiting pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:mah] +synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007193 ! G-protein signaling, adenylate cyclase inhibiting pathway + +[Term] +id: GO:0007199 +name: G-protein signaling, coupled to cGMP nucleotide second messenger +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase and a subsequent increase in the concentration of cyclic GMP." [GOC:mah, ISBN:0815316194] +synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] +synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] +is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger +is_a: GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0007200 +name: G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah, ISBN:0815316194] +synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway +is_a: GO:0048015 ! phosphoinositide-mediated signaling + +[Term] +id: GO:0007201 +name: G-protein dissociation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about. +is_obsolete: true + +[Term] +id: GO:0007202 +name: activation of phospholipase C activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] +comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. +synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051345 ! positive regulation of hydrolase activity +relationship: part_of GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0007203 +name: phosphatidylinositol-4,5-bisphosphate hydrolysis +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because hydrolysis is a reaction, not a process. +is_obsolete: true +consider: GO:0004435 + +[Term] +id: GO:0007204 +name: elevation of cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] +synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] +synonym: "cytosolic calcium ion concentration elevation" EXACT [] +synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] +synonym: "elevation of calcium ion concentration in cytosol" EXACT [] +synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] +is_a: GO:0051480 ! cytosolic calcium ion homeostasis + +[Term] +id: GO:0007205 +name: activation of protein kinase C activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] +synonym: "PKC activation" EXACT [] +synonym: "protein kinase C activation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0007206 +name: metabotropic glutamate receptor, phospholipase C activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah] +is_a: GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) +is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway + +[Term] +id: GO:0007207 +name: muscarinic acetylcholine receptor, phospholipase C activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah] +is_a: GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0007208 +name: serotonin receptor, phospholipase C activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah] +is_a: GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0007209 +name: tachykinin receptor, phospholipase C activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah] +is_a: GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0007210 +name: serotonin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "serotonin receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007211 +name: octopamine/tyramine signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an octopamine/tyramine receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "octopamine/tyramine signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007212 +name: dopamine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "dopamine receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007213 +name: acetylcholine receptor signaling, muscarinic pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine." [GOC:mah, ISBN:0815316194] +synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007214 +name: gamma-aminobutyric acid signaling pathway +namespace: biological_process +def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] +synonym: "4-aminobutanoate signaling pathway" EXACT [] +synonym: "4-aminobutanoate signalling pathway" EXACT [] +synonym: "4-aminobutyrate signaling pathway" EXACT [] +synonym: "4-aminobutyrate signalling pathway" EXACT [] +synonym: "GABA signaling pathway" EXACT [] +synonym: "GABA signalling pathway" EXACT [] +synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007215 +name: glutamate signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor." [GOC:mah, PMID:9131252] +synonym: "glutamate signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007216 +name: metabotropic glutamate receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins." [GOC:mah, PMID:9131252] +synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway +is_a: GO:0007215 ! glutamate signaling pathway + +[Term] +id: GO:0007217 +name: tachykinin signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] +synonym: "tachykinin signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007218 +name: neuropeptide signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] +synonym: "neuropeptide signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0007219 +name: Notch signaling pathway +namespace: biological_process +alt_id: GO:0030179 +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GOC:go_curators] +synonym: "N signaling pathway" EXACT [] +synonym: "N signalling pathway" EXACT [] +synonym: "Notch receptor signaling pathway" EXACT [] +synonym: "Notch receptor signalling pathway" EXACT [] +synonym: "Notch signalling pathway" EXACT [] +synonym: "Notch-receptor signaling pathway" EXACT [] +synonym: "Notch-receptor signalling pathway" EXACT [] +xref: Reactome:157118 +xref: Reactome:212079 +xref: Reactome:221837 +xref: Reactome:230401 +xref: Reactome:238447 +xref: Reactome:244988 +xref: Reactome:249867 +xref: Reactome:286699 +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007220 +name: Notch receptor processing +namespace: biological_process +def: "The series of successive proteolytic cleavage events that take place after a Notch receptor binds a ligand, and which lead to the release of the Notch Intracellular Domain (NICD), which is the active form of the receptor." [PMID:12651094, PMID:14986688] +synonym: "N receptor processing" EXACT [] +xref: Reactome:156988 +xref: Reactome:157212 +xref: Reactome:211864 +xref: Reactome:211871 +xref: Reactome:221629 +xref: Reactome:221636 +xref: Reactome:230222 +xref: Reactome:230229 +xref: Reactome:238261 +xref: Reactome:238268 +xref: Reactome:244833 +xref: Reactome:244840 +xref: Reactome:249732 +xref: Reactome:286586 +is_a: GO:0051605 ! protein maturation via proteolysis +relationship: part_of GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0007221 +name: positive regulation of transcription of Notch receptor target +namespace: biological_process +def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] +synonym: "N receptor target transcription factor activation" RELATED [] +synonym: "Notch receptor target transcription factor activation" RELATED [] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0007223 +name: Wnt receptor signaling pathway, calcium modulating pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] +synonym: "frizzled-2 signaling pathway" NARROW [] +synonym: "frizzled-2 signalling pathway" NARROW [] +synonym: "non-canonical Wnt signaling pathway" RELATED [] +is_a: GO:0016055 ! Wnt receptor signaling pathway + +[Term] +id: GO:0007224 +name: smoothened signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] +synonym: "hedgehog signaling pathway" EXACT [] +synonym: "hh signaling pathway" EXACT [] +synonym: "hh signalling pathway" EXACT [] +synonym: "smoothened signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007225 +name: patched ligand processing +namespace: biological_process +def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties." [PMID:15057936] +synonym: "Hedgehog protein processing" NARROW [] +is_a: GO:0016485 ! protein processing +relationship: part_of GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0007227 +name: signal transduction downstream of smoothened +namespace: biological_process +def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0007228 +name: positive regulation of hh target transcription factor activity +namespace: biological_process +def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] +synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051091 ! positive regulation of transcription factor activity +relationship: part_of GO:0007227 ! signal transduction downstream of smoothened + +[Term] +id: GO:0007229 +name: integrin-mediated signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GOC:mah] +synonym: "integrin-mediated signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007230 +name: calcium-o-sensing receptor pathway +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it does not make sense. +is_obsolete: true +consider: GO:0019722 + +[Term] +id: GO:0007231 +name: osmosensory signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl] +subset: gosubset_prok +synonym: "osmolarity sensing" EXACT [] +synonym: "osmolarity sensing signaling pathway" EXACT [] +synonym: "osmolarity sensing signalling pathway" EXACT [] +synonym: "osmosensory signalling pathway" EXACT [] +synonym: "signal transduction during osmotic stress" EXACT [] +is_a: GO:0006970 ! response to osmotic stress +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0007232 +name: osmosensory signaling pathway via Sho1 osmosensor +namespace: biological_process +def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl] +synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT [] +synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT [] +is_a: GO:0007231 ! osmosensory signaling pathway + +[Term] +id: GO:0007234 +name: osmosensory signaling pathway via two-component system +namespace: biological_process +def: "A series of molecular signals generated in response to osmotic change, as mediated through a two-component (phosphorelay) system." [PMID:9843501] +subset: gosubset_prok +synonym: "osmolarity sensing via two-component system" EXACT [] +synonym: "osmolarity signaling pathway via two-component system" EXACT [] +synonym: "osmolarity signalling pathway via two-component system" EXACT [] +synonym: "osmosensory signalling pathway via two-component system" EXACT [] +synonym: "signal transduction during osmotic stress via two-component system" EXACT [] +is_a: GO:0007231 ! osmosensory signaling pathway +relationship: part_of GO:0000160 ! two-component signal transduction system (phosphorelay) + +[Term] +id: GO:0007235 +name: activation of Ypd1 protein +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007236 +name: activation of Ssk1 protein +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007237 +name: activation of Ssk2/Ssk22 proteins +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007238 +name: activation of Pbs2 +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007239 +name: activation of Hog1 +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007240 +name: nuclear translocation of Hog1 +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007241 +name: inactivation of Hog1 +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +is_obsolete: true + +[Term] +id: GO:0007242 +name: intracellular signaling cascade +namespace: biological_process +def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "intracellular signalling cascade" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0007243 +name: protein kinase cascade +namespace: biological_process +def: "A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:jl, http://cancerweb.ncl.ac.uk/] +xref: Reactome:163358 +xref: Reactome:211745 +xref: Reactome:221512 +xref: Reactome:230132 +xref: Reactome:238158 +xref: Reactome:244747 +xref: Reactome:249654 +xref: Reactome:252437 +xref: Reactome:255603 +xref: Reactome:258983 +xref: Reactome:262353 +xref: Reactome:265200 +xref: Reactome:268322 +xref: Reactome:274021 +xref: Reactome:280499 +xref: Reactome:282794 +xref: Reactome:286520 +xref: Reactome:288299 +xref: Reactome:291709 +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0007244 +name: MAPKKK cascade (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007245 +name: activation of MAPKKK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007246 +name: activation of MAPKK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007247 +name: activation of MAPK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +consider: GO:0000750 + +[Term] +id: GO:0007248 +name: nuclear translocation of MAPK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007249 +name: I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GOC:jl, PMID:12773372] +synonym: "activation of the inhibitor of kappa kinase" RELATED [] +synonym: "NIK-I-kappaB/NF-kappaB cascade" EXACT [] +xref: Reactome:166058 +xref: Reactome:166166 +xref: Reactome:211840 +xref: Reactome:238238 +is_a: GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0007250 +name: activation of NF-kappaB-inducing kinase activity +namespace: biological_process +def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372] +synonym: "positive regulation of NF-kappaB-inducing kinase activity" EXACT [] +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0007251 +name: activation of the inhibitor of kappa kinase +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its meaning was unclear. +is_obsolete: true +consider: GO:0007249 + +[Term] +id: GO:0007252 +name: I-kappaB phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into an I-kappaB protein." [GOC:jl] +is_a: GO:0006468 ! protein amino acid phosphorylation +relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0007253 +name: cytoplasmic sequestering of NF-kappaB +namespace: biological_process +def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] +synonym: "cytoplasmic NF-kappaB retention" EXACT [] +synonym: "cytoplasmic NF-kappaB sequestration" EXACT [] +synonym: "cytoplasmic NF-kappaB storage" EXACT [] +synonym: "cytoplasmic retention of NF-kappaB" EXACT [] +synonym: "cytoplasmic sequestration of NF-kappaB" EXACT [] +synonym: "cytoplasmic storage of NF-kappaB" EXACT [] +synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042347 ! negative regulation of NF-kappaB import into nucleus +is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor +relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0007254 +name: JNK cascade +namespace: biological_process +def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] +synonym: "SAPK cascade" BROAD [] +synonym: "stress-activated protein kinase cascade" BROAD [] +is_a: GO:0000165 ! MAPKKK cascade +is_a: GO:0031098 ! stress-activated protein kinase signaling pathway + +[Term] +id: GO:0007256 +name: activation of JNKK activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] +synonym: "activation of JUN kinase kinase activity" EXACT [] +synonym: "positive regulation of JUNKK activity" BROAD [] +is_a: GO:0000186 ! activation of MAPKK activity +relationship: part_of GO:0007254 ! JNK cascade + +[Term] +id: GO:0007257 +name: activation of JNK activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK)." [GOC:bf] +synonym: "activation of JUN kinase activity" EXACT [] +synonym: "activation of SAPK activity" BROAD [] +is_a: GO:0000187 ! activation of MAPK activity +is_a: GO:0043507 ! positive regulation of JNK activity +relationship: part_of GO:0007254 ! JNK cascade + +[Term] +id: GO:0007258 +name: JUN phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl] +is_a: GO:0006468 ! protein amino acid phosphorylation +relationship: part_of GO:0007254 ! JNK cascade + +[Term] +id: GO:0007259 +name: JAK-STAT cascade +namespace: biological_process +def: "Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:jl, PMID:12039028] +is_a: GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0007260 +name: tyrosine phosphorylation of STAT protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation +relationship: part_of GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0007261 +name: JAK-induced STAT protein dimerization +namespace: biological_process +def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0007262 +name: STAT protein nuclear translocation +namespace: biological_process +def: "The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] +is_a: GO:0000060 ! protein import into nucleus, translocation +relationship: part_of GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0007263 +name: nitric oxide mediated signal transduction +namespace: biological_process +def: "A series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:jl] +synonym: "nitric oxide-mediated signal transduction" EXACT [] +synonym: "NO mediated signal transduction" EXACT [] +synonym: "NO-mediated signal transduction" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0007264 +name: small GTPase mediated signal transduction +namespace: biological_process +def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] +subset: gosubset_prok +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0007265 +name: Ras protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] +synonym: "Ras mediated signal transduction" EXACT [] +is_a: GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0007266 +name: Rho protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] +synonym: "Rho mediated signal transduction" EXACT [] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0007267 +name: cell-cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another." [GOC:mah] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +synonym: "cell-cell signalling" EXACT [] +is_a: GO:0007154 ! cell communication + +[Term] +id: GO:0007268 +name: synaptic transmission +namespace: biological_process +def: "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] +synonym: "neurotransmission" RELATED [GOC:dph] +synonym: "regulation of synapse" RELATED [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0007269 +name: neurotransmitter secretion +namespace: biological_process +def: "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, http://cancerweb.ncl.ac.uk] +synonym: "neurotransmitter release" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling +is_a: GO:0006836 ! neurotransmitter transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0007270 +name: nerve-nerve synaptic transmission +namespace: biological_process +def: "The process of communication from a neuron to another neuron across a synapse." [GOC:jl, MeSH:D009435] +is_a: GO:0007268 ! synaptic transmission + +[Term] +id: GO:0007271 +name: synaptic transmission, cholinergic +namespace: biological_process +def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:kmv] +is_a: GO:0007268 ! synaptic transmission + +[Term] +id: GO:0007272 +name: ensheathment of neurons +namespace: biological_process +def: "The process whereby glial cells envelop neuronal cell bodies and/or axons to form and insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] +synonym: "ionic insulation of neurons by glial cells" RELATED [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0007399 ! nervous system development +relationship: part_of GO:0019228 ! regulation of action potential in neuron + +[Term] +id: GO:0007273 +name: regulation of synapse +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term string made no sense. +is_obsolete: true +consider: GO:0007268 + +[Term] +id: GO:0007274 +name: neuromuscular synaptic transmission +namespace: biological_process +def: "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] +is_a: GO:0007268 ! synaptic transmission + +[Term] +id: GO:0007275 +name: multicellular organismal development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] +comment: Note that this term was 'developmental process'. +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0007276 +name: gamete generation +namespace: biological_process +alt_id: GO:0009552 +def: "The generation and maintenance of gametes. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] +synonym: "gamete generation (sensu Magnoliophyta)" RELATED [] +synonym: "gametogenesis" RELATED [] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0007277 +name: pole cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0007278 +name: pole cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0007277 ! pole cell development + +[Term] +id: GO:0007279 +name: pole cell formation +namespace: biological_process +def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] +comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. +is_a: GO:0007349 ! cellularization +relationship: part_of GO:0007277 ! pole cell development + +[Term] +id: GO:0007280 +name: pole cell migration +namespace: biological_process +def: "The directed movement of pole cells (germline progenitors in insects) from their site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] +comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. +is_a: GO:0008354 ! germ cell migration + +[Term] +id: GO:0007281 +name: germ cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the immature germ cell over time, from its formation to the mature structure (gamete)." [GOC:go_curators] +synonym: "germ-cell development" EXACT [] +synonym: "primordial germ cell development" NARROW [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0007282 +name: cystoblast division +namespace: biological_process +def: "The four rounds of incomplete mitosis undergone by the cystoblast to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells." [PMID:11131529] +synonym: "cystoblast cell division" EXACT [] +is_a: GO:0008356 ! asymmetric cell division +relationship: part_of GO:0007281 ! germ cell development + +[Term] +id: GO:0007283 +name: spermatogenesis +namespace: biological_process +def: "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "generation of spermatozoa" EXACT systematic_synonym [] +is_a: GO:0048232 ! male gamete generation + +[Term] +id: GO:0007284 +name: spermatogonial cell division +namespace: biological_process +def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form a cyst of secondary spermatogonia (primary spermatocytes)." [GOC:bf, ISBN:0879694238] +comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. +is_a: GO:0051301 ! cell division +relationship: part_of GO:0048136 ! male germ-line cyst formation + +[Term] +id: GO:0007285 +name: primary spermatocyte growth +namespace: biological_process +def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jic, ISBN:0879694238] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0007286 +name: spermatid development +namespace: biological_process +def: "The process whose specific outcome is the progression of a male gamete over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:go_curators] +synonym: "spermatid cell development" EXACT [] +synonym: "spermiogenesis" EXACT [] +is_a: GO:0007281 ! germ cell development +relationship: part_of GO:0048515 ! spermatid differentiation + +[Term] +id: GO:0007287 +name: Nebenkern formation +namespace: biological_process +def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238] +comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. +is_a: GO:0008053 ! mitochondrial fusion +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007288 +name: sperm axoneme assembly +namespace: biological_process +def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0035084 ! flagellar axoneme biogenesis +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007289 +name: spermatid nucleus differentiation +namespace: biological_process +def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] +comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. +synonym: "spermatid nuclear differentiation" EXACT [] +is_a: GO:0006997 ! nucleus organization +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007290 +name: spermatid nucleus elongation +namespace: biological_process +def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] +synonym: "spermatid nuclear elongation" EXACT [] +is_a: GO:0006997 ! nucleus organization +relationship: part_of GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0007291 +name: sperm individualization +namespace: biological_process +def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] +is_a: GO:0007349 ! cellularization +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007292 +name: female gamete generation +namespace: biological_process +def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0007276 ! gamete generation + +[Term] +id: GO:0007293 +name: germarium-derived egg chamber formation +namespace: biological_process +def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "egg chamber formation (sensu Insecta)" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007294 +name: germarium-derived oocyte fate determination +namespace: biological_process +alt_id: GO:0016350 +def: "Process by which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "maintenance of oocyte identity (sensu Insecta)" EXACT [] +synonym: "oocyte cell fate determination (sensu Insecta)" EXACT [] +synonym: "oocyte fate determination (sensu Insecta)" RELATED [] +is_a: GO:0030716 ! oocyte fate determination +relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation + +[Term] +id: GO:0007295 +name: growth of a germarium-derived egg chamber +namespace: biological_process +def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "egg chamber growth (sensu Insecta)" EXACT [] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007296 +name: vitellogenesis +namespace: biological_process +def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] +synonym: "yolk production" EXACT systematic_synonym [] +is_a: GO:0007028 ! cytoplasm organization +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0007297 +name: ovarian follicle cell migration +namespace: biological_process +def: "The directed movement of ovarian follicle cells that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg." [GOC:mtg_sensu, PMID:10822261] +synonym: "follicle cell migration (sensu Insecta)" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0007298 +name: border follicle cell migration +namespace: biological_process +def: "The directed movement of the border cells through the nurse cells to reach the oocyte." [GOC:mtg_sensu, PMID:10822261] +synonym: "border cell migration (sensu Insecta)" BROAD [] +synonym: "border follicle cell migration (sensu Insecta)" EXACT [] +is_a: GO:0007297 ! ovarian follicle cell migration + +[Term] +id: GO:0007299 +name: ovarian follicle cell adhesion +namespace: biological_process +def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells." [GOC:bf, GOC:mtg_sensu, PMID:12642496] +synonym: "follicle cell adhesion (sensu Insecta)" EXACT [] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0007300 +name: ovarian nurse cell to oocyte transport +namespace: biological_process +def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "nurse cell to oocyte transport (sensu Insecta)" EXACT [] +is_a: GO:0006810 ! transport +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007301 +name: ovarian ring canal formation +namespace: biological_process +def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] +is_a: GO:0030725 ! ring canal formation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0007302 +name: nurse cell nucleus anchoring +namespace: biological_process +def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0007303 +name: cytoplasmic transport, nurse cell to oocyte +namespace: biological_process +def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] +is_a: GO:0016482 ! cytoplasmic transport +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0007304 +name: chorion-containing eggshell formation +namespace: biological_process +def: "The construction of a chorion-containing eggshell." [GOC:mah, GOC:mtg_sensu] +synonym: "eggshell formation (sensu Insecta)" EXACT [] +is_a: GO:0030703 ! eggshell formation +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0007305 +name: vitelline membrane formation in chorion-containing eggshell +namespace: biological_process +def: "Construction of the vitelline membrane portion of a chorion-containing eggshells, such as those eggshells found in insects." [GOC:mah, GOC:mtg_sensu] +synonym: "vitelline membrane formation (sensu Insecta)" EXACT [] +is_a: GO:0030704 ! vitelline membrane formation +relationship: part_of GO:0007304 ! chorion-containing eggshell formation + +[Term] +id: GO:0007306 +name: eggshell chorion formation +namespace: biological_process +def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "insect chorion formation" RELATED [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007304 ! chorion-containing eggshell formation + +[Term] +id: GO:0007307 +name: eggshell chorion gene amplification +namespace: biological_process +def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] +is_a: GO:0006277 ! DNA amplification +relationship: part_of GO:0007306 ! eggshell chorion formation + +[Term] +id: GO:0007308 +name: oocyte construction +namespace: biological_process +alt_id: GO:0048110 +def: "The synthesis, deposition, and organization of the materials in a cell of an animal ovary that can then undergo meiosis and form an ovum." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte construction (sensu Insecta)" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048601 ! oocyte morphogenesis + +[Term] +id: GO:0007309 +name: oocyte axis specification +namespace: biological_process +alt_id: GO:0048111 +def: "The establishment, maintenance and elaboration of an axis in the oocyte." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte axis determination (sensu Insecta)" RELATED [] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0007308 ! oocyte construction + +[Term] +id: GO:0007310 +name: oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0008072 +alt_id: GO:0048123 +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte dorsal/ventral axis determination (sensu Insecta)" RELATED [] +is_a: GO:0007309 ! oocyte axis specification +is_a: GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0007311 +name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded +namespace: biological_process +alt_id: GO:0048124 +def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb] +synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded (sensu Insecta)" RELATED [] +is_a: GO:0007310 ! oocyte dorsal/ventral axis specification + +[Term] +id: GO:0007312 +name: oocyte nucleus migration during oocyte axis specification +namespace: biological_process +alt_id: GO:0008102 +alt_id: GO:0048128 +def: "The directed movement of the oocyte nucleus within the cell during the establishment and maintenance of the axes of the oocyte." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] +synonym: "oocyte axis determination, oocyte nuclear migration" EXACT [] +synonym: "oocyte axis determination, oocyte nuclear migration (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus migration" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus migration (sensu Insecta)" EXACT [] +synonym: "oocyte nuclear migration during oocyte axis determination" EXACT [] +synonym: "oocyte nuclear migration during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte nucleus migration during oocyte axis determination (sensu Insecta)" RELATED [] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0030722 ! establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification + +[Term] +id: GO:0007313 +name: maternal specification of dorsal/ventral axis, oocyte, soma encoded +namespace: biological_process +alt_id: GO:0048125 +def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb] +synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded (sensu Insecta)" RELATED [] +is_a: GO:0007310 ! oocyte dorsal/ventral axis specification + +[Term] +id: GO:0007314 +name: oocyte anterior/posterior axis specification +namespace: biological_process +alt_id: GO:0048112 +def: "Polarization of the oocyte along its anterior-posterior axis." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte anterior/posterior axis determination (sensu Insecta)" RELATED [] +is_a: GO:0007309 ! oocyte axis specification +is_a: GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0007315 +name: pole plasm assembly +namespace: biological_process +alt_id: GO:0048113 +def: "Establishment of the specialized cytoplasm found at the poles of the egg." [GOC:mtg_sensu] +synonym: "pole plasm assembly (sensu Insecta)" RELATED [] +is_a: GO:0007028 ! cytoplasm organization +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification + +[Term] +id: GO:0007316 +name: pole plasm RNA localization +namespace: biological_process +alt_id: GO:0048116 +def: "Any process by which RNA is transported to, or maintained in, the oocyte pole plasm." [GOC:ai] +synonym: "establishment and maintenance of pole plasm RNA localization" EXACT [] +synonym: "oocyte pole plasm RNA localization" EXACT [] +synonym: "pole plasm RNA localization (sensu Insecta)" EXACT [] +is_a: GO:0006403 ! RNA localization +relationship: part_of GO:0007315 ! pole plasm assembly + +[Term] +id: GO:0007317 +name: regulation of pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] +synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT [] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0060281 ! regulation of oocyte development +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization + +[Term] +id: GO:0007318 +name: pole plasm protein localization +namespace: biological_process +alt_id: GO:0048115 +def: "Any process by which a protein is transported to, or maintained in, the oocyte pole plasm." [GOC:ai] +synonym: "establishment and maintenance of pole plasm protein localization" EXACT [] +synonym: "oocyte pole plasm protein localization" EXACT [] +synonym: "pole plasm protein localization (sensu Insecta)" EXACT [] +is_a: GO:0008105 ! asymmetric protein localization +relationship: part_of GO:0007315 ! pole plasm assembly + +[Term] +id: GO:0007319 +name: negative regulation of oskar mRNA translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] +synonym: "down regulation of oskar mRNA translation" EXACT [] +synonym: "down-regulation of oskar mRNA translation" EXACT [] +synonym: "downregulation of oskar mRNA translation" EXACT [] +synonym: "inhibition of oskar mRNA translation" NARROW [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0046011 ! regulation of oskar mRNA translation + +[Term] +id: GO:0007320 +name: insemination +namespace: biological_process +def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007620 ! copulation + +[Term] +id: GO:0007321 +name: sperm displacement +namespace: biological_process +def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373] +is_a: GO:0046692 ! sperm competition + +[Term] +id: GO:0007323 +name: peptide pheromone maturation +namespace: biological_process +alt_id: GO:0007324 +alt_id: GO:0007326 +alt_id: GO:0046613 +def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification." [GOC:elh] +subset: gosubset_prok +synonym: "a-factor processing (proteolytic)" NARROW [] +synonym: "alpha-factor maturation" NARROW [] +synonym: "pheromone processing" EXACT [] +synonym: "pheromone processing (sensu Saccharomyces)" NARROW [] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0007329 +name: positive regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] +synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] +synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +is_a: GO:0009371 ! positive regulation of transcription by pheromones +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones + +[Term] +id: GO:0007336 +name: bilateral process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it gives no indication of what it refers to. +is_obsolete: true + +[Term] +id: GO:0007337 +name: unilateral process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it gives no indication of what it refers to. +is_obsolete: true + +[Term] +id: GO:0007338 +name: single fertilization +namespace: biological_process +def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] +synonym: "fertilization (sensu Metazoa)" EXACT [] +synonym: "zygote biosynthesis" BROAD [] +synonym: "zygote formation" BROAD [] +is_a: GO:0009566 ! fertilization + +[Term] +id: GO:0007339 +name: binding of sperm to zona pellucida +namespace: biological_process +def: "The process by which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] +synonym: "ZPG binding" RELATED [] +is_a: GO:0035036 ! sperm-egg recognition + +[Term] +id: GO:0007340 +name: acrosome reaction +namespace: biological_process +def: "The discharge, by sperm, of a single, anterior secretory granule following their attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the disperasl of the acrosomal contents into the egg." [GOC:dph, PMID:3886029] +is_a: GO:0017156 ! calcium ion-dependent exocytosis +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007341 +name: penetration of zona pellucida +namespace: biological_process +def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007342 +name: fusion of sperm to egg plasma membrane +namespace: biological_process +def: "The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +synonym: "sperm-oocyte fusion" NARROW [] +is_a: GO:0045026 ! plasma membrane fusion +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007343 +name: egg activation +namespace: biological_process +def: "The process whereby the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007344 +name: pronuclear fusion +namespace: biological_process +def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] +is_a: GO:0000741 ! karyogamy +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007345 +name: embryogenesis and morphogenesis +namespace: biological_process +def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888] +comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis. +is_obsolete: true +consider: GO:0009653 +consider: GO:0009790 + +[Term] +id: GO:0007346 +name: regulation of mitotic cell cycle +namespace: biological_process +def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "control of mitotic cell cycle progression" EXACT [] +synonym: "mitotic cell cycle control" EXACT [] +synonym: "mitotic cell cycle modulation" EXACT [] +synonym: "mitotic cell cycle regulation" EXACT [] +synonym: "mitotic cell cycle regulator" RELATED [] +synonym: "modulation of mitotic cell cycle progression" EXACT [] +synonym: "regulation of mitotic cell cycle progression" EXACT [] +synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051726 ! regulation of cell cycle +relationship: regulates GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0007347 +name: regulation of preblastoderm mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "control of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "preblastoderm mitotic cell cycle control" EXACT [] +synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] +synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] +synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] +synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle + +[Term] +id: GO:0007348 +name: regulation of syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "control of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] +synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "syncytial blastoderm cell cycle control" EXACT [] +synonym: "syncytial blastoderm cell cycle modulation" EXACT [] +synonym: "syncytial blastoderm cell cycle regulation" EXACT [] +synonym: "syncytial blastoderm cell cycle regulator" RELATED [] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +is_a: GO:0022402 ! cell cycle process +relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle + +[Term] +id: GO:0007349 +name: cellularization +namespace: biological_process +alt_id: GO:0009796 +def: "The separation of a multi-nucleate cell or syncytium into individual cells." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] +synonym: "cellularization (sensu Metazoa)" NARROW [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0007350 +name: blastoderm segmentation +namespace: biological_process +def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009880 ! embryonic pattern specification +is_a: GO:0035282 ! segmentation + +[Term] +id: GO:0007351 +name: tripartite regional subdivision +namespace: biological_process +def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0007352 +name: zygotic determination of dorsal/ventral axis +namespace: biological_process +def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] +is_a: GO:0000578 ! embryonic axis specification +is_a: GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0007353 +name: ventral/lateral system +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0009880 + +[Term] +id: GO:0007354 +name: zygotic determination of anterior/posterior axis, embryo +namespace: biological_process +def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0008595 ! determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007355 +name: anterior region determination +namespace: biological_process +def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007356 +name: thorax and anterior abdomen determination +namespace: biological_process +def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007357 +name: positive regulation of central gap gene transcription +namespace: biological_process +def: "The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +synonym: "activation of central gap gene" BROAD [] +synonym: "activation of central gap gene transcription" NARROW [] +synonym: "stimulation of central gap gene transcription" NARROW [] +synonym: "up regulation of central gap gene transcription" EXACT [] +synonym: "up-regulation of central gap gene transcription" EXACT [] +synonym: "upregulation of central gap gene transcription" EXACT [] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0007356 ! thorax and anterior abdomen determination + +[Term] +id: GO:0007358 +name: establishment of central gap gene boundaries +namespace: biological_process +def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0007356 ! thorax and anterior abdomen determination + +[Term] +id: GO:0007359 +name: posterior abdomen determination +namespace: biological_process +def: "The regionalization process by which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +comment: Note that this process is exemplified in insects by the actions of the knirps gene product. +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007360 +name: positive regulation of posterior gap gene transcription +namespace: biological_process +def: "The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +synonym: "activation of posterior gap gene" BROAD [] +synonym: "activation of posterior gap gene transcription" NARROW [] +synonym: "knirps activation" NARROW [] +synonym: "stimulation of posterior gap gene transcription" NARROW [] +synonym: "up regulation of posterior gap gene transcription" EXACT [] +synonym: "up-regulation of posterior gap gene transcription" EXACT [] +synonym: "upregulation of posterior gap gene transcription" EXACT [] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0007359 ! posterior abdomen determination + +[Term] +id: GO:0007361 +name: establishment of posterior gap gene boundaries +namespace: biological_process +def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0007359 ! posterior abdomen determination + +[Term] +id: GO:0007362 +name: terminal region determination +namespace: biological_process +def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009880 ! embryonic pattern specification +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007363 +name: positive regulation of terminal gap gene transcription +namespace: biological_process +def: "The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +synonym: "activation of terminal gap gene" BROAD [] +synonym: "activation of terminal gap gene transcription" NARROW [] +synonym: "stimulation of terminal gap gene transcription" NARROW [] +synonym: "up regulation of terminal gap gene transcription" EXACT [] +synonym: "up-regulation of terminal gap gene transcription" EXACT [] +synonym: "upregulation of terminal gap gene transcription" EXACT [] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0007362 ! terminal region determination + +[Term] +id: GO:0007364 +name: establishment of terminal gap gene boundary +namespace: biological_process +def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0007362 ! terminal region determination + +[Term] +id: GO:0007365 +name: periodic partitioning +namespace: biological_process +def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] +comment: Note that examples of periodic partitions are tagmata, segments or parasegments. +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0007366 +name: periodic partitioning by pair rule gene +namespace: biological_process +def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] +is_a: GO:0007365 ! periodic partitioning + +[Term] +id: GO:0007367 +name: segment polarity determination +namespace: biological_process +def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] +is_a: GO:0007365 ! periodic partitioning + +[Term] +id: GO:0007368 +name: determination of left/right symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jic] +is_a: GO:0009855 ! determination of bilateral symmetry + +[Term] +id: GO:0007369 +name: gastrulation +namespace: biological_process +def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0007370 +name: ventral furrow formation +namespace: biological_process +def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007371 +name: ventral midline determination +namespace: biological_process +def: "The regionalization process by which the area where the ventral furrow will begin invagination is specified." [GOC:dph, GOC:isa_complete] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007370 ! ventral furrow formation + +[Term] +id: GO:0007372 +name: determination of anterior border of ventral midline +namespace: biological_process +is_a: GO:0007371 ! ventral midline determination + +[Term] +id: GO:0007373 +name: determination of posterior border of ventral midline +namespace: biological_process +is_a: GO:0007371 ! ventral midline determination + +[Term] +id: GO:0007374 +name: posterior midgut invagination +namespace: biological_process +def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007375 +name: anterior midgut invagination +namespace: biological_process +def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:08795694238] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007376 +name: cephalic furrow formation +namespace: biological_process +def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:08795694238] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007377 +name: germ-band extension +namespace: biological_process +def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007378 +name: amnioserosa formation +namespace: biological_process +def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007379 +name: segment specification +namespace: biological_process +def: "The process whereby segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009880 ! embryonic pattern specification +relationship: part_of GO:0035282 ! segmentation + +[Term] +id: GO:0007380 +name: specification of segmental identity, head +namespace: biological_process +def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +is_a: GO:0007379 ! segment specification +relationship: part_of GO:0035287 ! head segmentation + +[Term] +id: GO:0007381 +name: specification of segmental identity, labial segment +namespace: biological_process +def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035289 ! posterior head segmentation + +[Term] +id: GO:0007382 +name: specification of segmental identity, maxillary segment +namespace: biological_process +def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035289 ! posterior head segmentation + +[Term] +id: GO:0007383 +name: specification of segmental identity, antennal segment +namespace: biological_process +def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035288 ! anterior head segmentation + +[Term] +id: GO:0007384 +name: specification of segmental identity, thorax +namespace: biological_process +def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +is_a: GO:0035292 ! specification of segmental identity, trunk + +[Term] +id: GO:0007385 +name: specification of segmental identity, abdomen +namespace: biological_process +def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +is_a: GO:0035292 ! specification of segmental identity, trunk + +[Term] +id: GO:0007386 +name: compartment specification +namespace: biological_process +def: "The regionalization process by which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009952 ! anterior/posterior pattern formation + +[Term] +id: GO:0007387 +name: anterior compartment specification +namespace: biological_process +def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0007386 ! compartment specification + +[Term] +id: GO:0007388 +name: posterior compartment specification +namespace: biological_process +def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0007386 ! compartment specification + +[Term] +id: GO:0007389 +name: pattern specification process +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] +synonym: "pattern biosynthesis" RELATED [] +synonym: "pattern formation" RELATED [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0007390 +name: germ-band shortening +namespace: biological_process +def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] +synonym: "germ-band retraction" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0007391 +name: dorsal closure +namespace: biological_process +def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0007392 +name: initiation of dorsal closure +namespace: biological_process +def: "Events that occur at the start of dorsal closure." [GOC:bf] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0007393 +name: dorsal closure, leading edge cell fate determination +namespace: biological_process +def: "Process by which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] +is_a: GO:0035028 ! leading edge cell fate determination +relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment + +[Term] +id: GO:0007394 +name: dorsal closure, elongation of leading edge cells +namespace: biological_process +def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] +is_a: GO:0009826 ! unidimensional cell growth +is_a: GO:0016476 ! regulation of embryonic cell shape +relationship: part_of GO:0007392 ! initiation of dorsal closure + +[Term] +id: GO:0007395 +name: dorsal closure, spreading of leading edge cells +namespace: biological_process +def: "Dorsally-directed movement of the cells at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0007396 +name: suture of dorsal opening +namespace: biological_process +def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0007397 +name: histogenesis and organogenesis +namespace: biological_process +def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems] +comment: This term was made obsolete because more appropriate terms were created. +is_obsolete: true +consider: GO:0009887 +consider: GO:0009888 + +[Term] +id: GO:0007398 +name: ectoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0007399 +name: nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] +synonym: "neurite biosynthesis" EXACT [] +synonym: "neurite formation" EXACT [] +synonym: "neurite growth" EXACT [] +synonym: "pan-neural process" RELATED [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0007400 +name: neuroblast fate determination +namespace: biological_process +alt_id: GO:0007408 +alt_id: GO:0043347 +alt_id: GO:0043348 +def: "Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "neuroblast cell fate determination" EXACT [] +synonym: "neuroblast fate determination (sensu Nematoda and Protostomia)" EXACT [] +synonym: "neuroblast fate determination (sensu Vertebrata)" EXACT [] +synonym: "neuroblast identity determination" EXACT [] +is_a: GO:0048867 ! stem cell fate determination +relationship: part_of GO:0014017 ! neuroblast fate commitment + +[Term] +id: GO:0007401 +name: pan-neural process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because its meaning is ambiguous. +is_obsolete: true +consider: GO:0007399 +consider: GO:0050877 + +[Term] +id: GO:0007402 +name: ganglion mother cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0048867 ! stem cell fate determination + +[Term] +id: GO:0007403 +name: glial cell fate determination +namespace: biological_process +alt_id: GO:0043361 +def: "Process by which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu] +synonym: "glial cell fate determination (sensu Nematoda and Protostomia)" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0021781 ! glial cell fate commitment + +[Term] +id: GO:0007405 +name: neuroblast proliferation +namespace: biological_process +alt_id: GO:0043349 +alt_id: GO:0043350 +def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] +synonym: "neuroblast proliferation (sensu Nematoda and Protostomia)" EXACT [] +synonym: "neuroblast proliferation (sensu Vertebrata)" EXACT [] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0007406 +name: negative regulation of neuroblast proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] +synonym: "down regulation of neuroblast proliferation" EXACT [] +synonym: "down-regulation of neuroblast proliferation" EXACT [] +synonym: "downregulation of neuroblast proliferation" EXACT [] +synonym: "inhibition of neuroblast proliferation" NARROW [] +synonym: "suppression of neuroblast proliferation" EXACT [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0050768 ! negative regulation of neurogenesis +relationship: negatively_regulates GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:0007407 +name: neuroblast activation +namespace: biological_process +alt_id: GO:0043351 +alt_id: GO:0043352 +def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] +synonym: "neuroblast activation (sensu Nematoda and Protostomia)" EXACT [] +synonym: "neuroblast activation (sensu Vertebrata)" EXACT [] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0007409 +name: axonogenesis +namespace: biological_process +alt_id: GO:0007410 +def: "Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "axon growth" NARROW [] +synonym: "neuron long process generation" EXACT systematic_synonym [] +is_a: GO:0048812 ! neurite morphogenesis + +[Term] +id: GO:0007411 +name: axon guidance +namespace: biological_process +alt_id: GO:0008040 +def: "The process by which the migration of an axon growth cone is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] +synonym: "axon growth cone guidance" NARROW [] +is_a: GO:0006928 ! cell motion +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0007412 +name: axon target recognition +namespace: biological_process +def: "The process by which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0007413 +name: axonal fasciculation +namespace: biological_process +def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] +synonym: "fasciculation of neuron" RELATED [] +is_a: GO:0008038 ! neuron recognition +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0007414 +name: axonal defasciculation +namespace: biological_process +def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] +synonym: "defasciculation of neuron" RELATED [] +is_a: GO:0008038 ! neuron recognition +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0007415 +name: defasciculation of motor neuron axon +namespace: biological_process +def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] +is_a: GO:0007414 ! axonal defasciculation + +[Term] +id: GO:0007416 +name: synaptogenesis +namespace: biological_process +def: "The biosynthesis of a synapse." [http://cancerweb.ncl.ac.uk/] +synonym: "synapse biogenesis" EXACT systematic_synonym [] +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007417 +name: central nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jic, ISBN:0582227089] +synonym: "CNS development" EXACT [] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007418 +name: ventral midline development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0007419 +name: ventral cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0007420 +name: brain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0007421 +name: stomatogastric nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007422 +name: peripheral nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, http://cancerweb.ncl.ac.uk] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007423 +name: sensory organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] +synonym: "sense organ development" EXACT [GOC:dph] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0007424 +name: open tracheal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles." [GOC:mtg_sensu, PMID:8625828] +comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. +synonym: "trachea development (sensu Insecta)" EXACT [] +synonym: "tracheal system development (sensu Insecta)" EXACT [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0007425 +name: epithelial cell fate determination, open tracheal system +namespace: biological_process +alt_id: GO:0046846 +def: "Process by which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes)." [GOC:mtg_sensu, PMID:11063940] +synonym: "tracheal cell fate determination (sensu Insecta)" BROAD [] +synonym: "tracheal epithelial cell fate determination (sensu Insecta)" EXACT [] +synonym: "tracheal placode cell fate determination (sensu Insecta)" RELATED [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007426 +name: tracheal outgrowth, open tracheal system +namespace: biological_process +def: "The projection of branches of an open tracheal system towards their target tissues." [GOC:bf, GOC:mtg_sensu] +synonym: "tracheal outgrowth (sensu Insecta)" EXACT [] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007427 +name: epithelial cell migration, open tracheal system +namespace: biological_process +def: "The orderly movement of epithelial cells during development of an open tracheal system." [GOC:bf, GOC:mtg_sensu] +synonym: "tracheal cell migration (sensu Insecta)" BROAD [] +synonym: "tracheal epithelial cell migration (sensu Insecta)" RELATED [] +is_a: GO:0010631 ! epithelial cell migration +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007428 +name: primary branching, open tracheal system +namespace: biological_process +def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] +synonym: "primary tracheal branching (sensu Insecta)" EXACT [] +is_a: GO:0048754 ! branching morphogenesis of a tube +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007429 +name: secondary branching, open tracheal system +namespace: biological_process +def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] +synonym: "secondary tracheal branching (sensu Insecta)" EXACT [] +is_a: GO:0048754 ! branching morphogenesis of a tube +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007430 +name: terminal branching, open tracheal system +namespace: biological_process +def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] +synonym: "terminal branching of trachea, cytoplasmic projection extension (sensu Insecta)" EXACT [] +is_a: GO:0048754 ! branching morphogenesis of a tube +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007431 +name: salivary gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035272 ! exocrine system development + +[Term] +id: GO:0007432 +name: salivary gland boundary specification +namespace: biological_process +def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] +synonym: "salivary gland determination" EXACT [] +is_a: GO:0010160 ! formation of organ boundary +relationship: part_of GO:0007431 ! salivary gland development + +[Term] +id: GO:0007433 +name: larval salivary gland boundary specification +namespace: biological_process +def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] +synonym: "larval salivary gland determination" BROAD [GOC:tb] +is_a: GO:0007432 ! salivary gland boundary specification +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0007434 +name: adult salivary gland boundary specification +namespace: biological_process +def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] +synonym: "larval salivary gland determination" BROAD [GOC:tb] +is_a: GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0007435 +name: salivary gland morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0007431 ! salivary gland development + +[Term] +id: GO:0007436 +name: larval salivary gland morphogenesis +namespace: biological_process +def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0007435 ! salivary gland morphogenesis +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0007437 +name: adult salivary gland morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the adult salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0007438 +name: oenocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0001742 ! oenocyte differentiation + +[Term] +id: GO:0007439 +name: ectodermal gut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. The ectodermal gut includes those portions of the gut that are derived from ectoderm." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048565 ! gut development + +[Term] +id: GO:0007440 +name: foregut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the foregut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048567 ! ectodermal gut morphogenesis + +[Term] +id: GO:0007441 +name: anterior midgut (ectodermal) morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0048567 ! ectodermal gut morphogenesis + +[Term] +id: GO:0007442 +name: hindgut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the hindgut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048567 ! ectodermal gut morphogenesis + +[Term] +id: GO:0007443 +name: Malpighian tubule morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. Morphogenesis pertains to the creation of form. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] +comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis + +[Term] +id: GO:0007444 +name: imaginal disc development +namespace: biological_process +def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, http://cancerweb.ncl.ac.uk/] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0007445 +name: determination of imaginal disc primordium +namespace: biological_process +def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0007444 ! imaginal disc development + +[Term] +id: GO:0007446 +name: imaginal disc growth +namespace: biological_process +def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jic, PMID:10679387] +is_a: GO:0035265 ! organ growth +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0007444 ! imaginal disc development + +[Term] +id: GO:0007447 +name: imaginal disc pattern formation +namespace: biological_process +def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jic] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007444 ! imaginal disc development + +[Term] +id: GO:0007448 +name: anterior/posterior pattern formation, imaginal disc +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, http://cancerweb.ncl.ac.uk] +is_a: GO:0007447 ! imaginal disc pattern formation +is_a: GO:0009952 ! anterior/posterior pattern formation + +[Term] +id: GO:0007449 +name: proximal/distal pattern formation, imaginal disc +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0007447 ! imaginal disc pattern formation +is_a: GO:0009954 ! proximal/distal pattern formation + +[Term] +id: GO:0007450 +name: dorsal/ventral pattern formation, imaginal disc +namespace: biological_process +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0007447 ! imaginal disc pattern formation +is_a: GO:0009953 ! dorsal/ventral pattern formation + +[Term] +id: GO:0007451 +name: dorsal/ventral lineage restriction, imaginal disc +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] +is_a: GO:0035161 ! imaginal disc lineage restriction +relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc + +[Term] +id: GO:0007453 +name: clypeo-labral disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the clypeo-labral disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238] +synonym: "clypeo-labral disc metamorphosis" EXACT [] +synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0007454 +name: labial disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the labial disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] +synonym: "labial disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035217 ! labial disc development + +[Term] +id: GO:0007455 +name: eye-antennal disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the eye-antennal disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] +synonym: "eye-antennal disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035214 ! eye-antennal disc development + +[Term] +id: GO:0007458 +name: progression of morphogenetic furrow during compound eye morphogenesis +namespace: biological_process +def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] +synonym: "progression of morphogenetic furrow (sensu Endopterygota)" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0007460 +name: R8 cell fate commitment +namespace: biological_process +alt_id: GO:0007461 +def: "The process whereby the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] +synonym: "restriction of R8 fate" EXACT [] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0007462 +name: R1/R6 cell fate commitment +namespace: biological_process +def: "The process whereby the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0048052 ! R1/R6 cell differentiation + +[Term] +id: GO:0007463 +name: R2/R5 cell fate commitment +namespace: biological_process +def: "The process whereby the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0048054 ! R2/R5 cell differentiation + +[Term] +id: GO:0007464 +name: R3/R4 cell fate commitment +namespace: biological_process +def: "The process whereby the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0042067 ! establishment of ommatidial polarity +relationship: part_of GO:0048056 ! R3/R4 cell differentiation + +[Term] +id: GO:0007465 +name: R7 cell fate commitment +namespace: biological_process +def: "The process whereby the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0007468 +name: regulation of rhodopsin gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression +relationship: part_of GO:0042461 ! photoreceptor cell development + +[Term] +id: GO:0007469 +name: antennal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +relationship: part_of GO:0035214 ! eye-antennal disc development + +[Term] +id: GO:0007470 +name: prothoracic disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the prothoracic disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] +synonym: "prothoracic disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +is_a: GO:0035219 ! prothoracic disc development + +[Term] +id: GO:0007471 +name: prothoracic morphogenesis +namespace: biological_process +def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process. +is_obsolete: true +consider: GO:0007470 + +[Term] +id: GO:0007472 +name: wing disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the wing disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] +synonym: "wing disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0007473 +name: wing disc proximal/distal pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] +is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc +is_a: GO:0035222 ! wing disc pattern formation + +[Term] +id: GO:0007474 +name: imaginal disc-derived wing vein specification +namespace: biological_process +def: "The regionalization process by which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] +synonym: "wing vein specification" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0007475 +name: apposition of dorsal and ventral imaginal disc-derived wing surfaces +namespace: biological_process +def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] +synonym: "apposition of dorsal and ventral wing surfaces" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis + +[Term] +id: GO:0007476 +name: imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the imaginal disc-derived wing are generated and organized. Morphogenesis pertains to the creation of form. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] +synonym: "wing morphogenesis" EXACT [] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +relationship: part_of GO:0007472 ! wing disc morphogenesis + +[Term] +id: GO:0007477 +name: notum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0007478 +name: leg disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the leg disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] +synonym: "leg disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035218 ! leg disc development + +[Term] +id: GO:0007479 +name: leg disc proximal/distal pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] +is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc +is_a: GO:0035223 ! leg disc pattern formation + +[Term] +id: GO:0007480 +name: imaginal disc-derived leg morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a leg derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands." [GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/] +synonym: "leg morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0035109 ! imaginal disc-derived limb morphogenesis +is_a: GO:0035110 ! leg morphogenesis +relationship: part_of GO:0007478 ! leg disc morphogenesis + +[Term] +id: GO:0007481 +name: haltere disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the haltere disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] +synonym: "haltere disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035216 ! haltere disc development + +[Term] +id: GO:0007482 +name: haltere development +namespace: biological_process +def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jic, http://www.earthlife.net] +is_a: GO:0048737 ! imaginal disc-derived appendage development +relationship: part_of GO:0035216 ! haltere disc development + +[Term] +id: GO:0007483 +name: genital disc morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the genital disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] +synonym: "genital disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0007484 +name: imaginal disc-derived genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure." [GOC:ai, GOC:sensu] +synonym: "genital development (sensu Endopterygota)" EXACT [] +synonym: "genitalia development (sensu Endopterygota)" EXACT [] +is_a: GO:0048806 ! genitalia development +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0007485 +name: imaginal disc-derived male genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure." [GOC:ai, GOC:sensu] +synonym: "male genital development (sensu Endopterygota)" EXACT [] +synonym: "male genitalia development (sensu Endopterygota)" EXACT [] +is_a: GO:0007484 ! imaginal disc-derived genitalia development + +[Term] +id: GO:0007486 +name: imaginal disc-derived female genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure." [GOC:ai, GOC:sensu] +synonym: "female genital development (sensu Endopterygota)" EXACT [] +synonym: "female genitalia development (sensu Endopterygota)" EXACT [] +is_a: GO:0007484 ! imaginal disc-derived genitalia development +is_a: GO:0030540 ! female genitalia development + +[Term] +id: GO:0007487 +name: analia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [GOC:ai, GOC:mtg_sensu] +synonym: "analia development (sensu Endopterygota)" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0007488 +name: histoblast morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures derived from the histoblast disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] +synonym: "histoblast metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0007489 +name: maintenance of imaginal histoblast diploidy +namespace: biological_process +def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238] +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: part_of GO:0007488 ! histoblast morphogenesis + +[Term] +id: GO:0007490 +name: tergite morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the tergite are generated and organized. Morphogenesis pertains to the creation of form. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jic, http://www.earthlife.net] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007488 ! histoblast morphogenesis + +[Term] +id: GO:0007491 +name: sternite morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the sternite are generated and organized. Morphogenesis pertains to the creation of form. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jic, http://www.earthlife.net] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007488 ! histoblast morphogenesis + +[Term] +id: GO:0007492 +name: endoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0007493 +name: endodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] +comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. +synonym: "endoderm cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0001706 ! endoderm formation +relationship: part_of GO:0001711 ! endodermal cell fate commitment + +[Term] +id: GO:0007494 +name: midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048565 ! gut development + +[Term] +id: GO:0007495 +name: visceral mesoderm-endoderm interaction involved in midgut development +namespace: biological_process +def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete] +synonym: "visceral mesoderm/endoderm interaction" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0007494 ! midgut development + +[Term] +id: GO:0007496 +name: anterior midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007494 ! midgut development + +[Term] +id: GO:0007497 +name: posterior midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007494 ! midgut development + +[Term] +id: GO:0007498 +name: mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0007499 +name: ectoderm and mesoderm interaction +namespace: biological_process +def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] +synonym: "ectoderm/mesoderm interaction" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0007500 +name: mesodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] +comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. +synonym: "mesoderm cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0001710 ! mesodermal cell fate commitment + +[Term] +id: GO:0007501 +name: mesodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. +synonym: "mesoderm cell fate specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0001710 ! mesodermal cell fate commitment + +[Term] +id: GO:0007502 +name: gut mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gut mesoderm over time, from its formation to the mature structure. The gut mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gut of the organism." [GOC:ai] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0007503 +name: fat body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0007504 +name: larval fat body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238] +is_a: GO:0007503 ! fat body development +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0007505 +name: adult fat body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238] +is_a: GO:0007503 ! fat body development + +[Term] +id: GO:0007506 +name: gonadal mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] +is_a: GO:0007498 ! mesoderm development +relationship: part_of GO:0008406 ! gonad development + +[Term] +id: GO:0007507 +name: heart development +namespace: biological_process +alt_id: GO:0007511 +def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "cardiac development" RELATED [] +synonym: "dorsal vessel development" NARROW [] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0007508 +name: larval heart development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238] +is_a: GO:0007507 ! heart development +relationship: part_of GO:0002164 ! larval development + +[Term] +id: GO:0007509 +name: mesoderm migration +namespace: biological_process +def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0001707 ! mesoderm formation + +[Term] +id: GO:0007510 +name: cardioblast cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0042684 ! cardioblast cell fate commitment + +[Term] +id: GO:0007512 +name: adult heart development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf] +synonym: "adult cardiac development" RELATED [] +is_a: GO:0007507 ! heart development + +[Term] +id: GO:0007513 +name: pericardial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized features of a pericardial cell. In insects, pericardial cells are loosely arranged non-myogenic cells that flank the cardioblasts and probably act in the filtration of hemolymph." [GOC:bf, PMID:12435360] +is_a: GO:0035051 ! cardiac cell differentiation + +[Term] +id: GO:0007514 +name: garland cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis." [PMID:7588884] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0007515 +name: lymph gland development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jic, http://cancerweb.ncl.ac.uk] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0048535 +consider: GO:0048542 + +[Term] +id: GO:0007516 +name: hemocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "arthropod blood cell development" EXACT [] +synonym: "hemocyte development (sensu Arthropoda)" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0007517 +name: muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jic, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0007518 +name: myoblast cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0048625 ! myoblast cell fate commitment + +[Term] +id: GO:0007519 +name: skeletal muscle development +namespace: biological_process +alt_id: GO:0048637 +def: "The developmental sequence of events leading to the formation of adult muscle that occurs in the anima. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/] +synonym: "myogenesis" RELATED [] +is_a: GO:0014706 ! striated muscle development + +[Term] +id: GO:0007520 +name: myoblast fusion +namespace: biological_process +def: "A process whereby non-proliferating myoblasts fuse to existing fibres or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/] +is_a: GO:0000768 ! syncytium formation by plasma membrane fusion +relationship: part_of GO:0014902 ! myotube differentiation + +[Term] +id: GO:0007521 +name: muscle cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0007517 ! muscle development +relationship: part_of GO:0042693 ! muscle cell fate commitment + +[Term] +id: GO:0007522 +name: visceral muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0007517 ! muscle development + +[Term] +id: GO:0007523 +name: larval visceral muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0007522 ! visceral muscle development +relationship: part_of GO:0002164 ! larval development + +[Term] +id: GO:0007524 +name: adult visceral muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0007522 ! visceral muscle development + +[Term] +id: GO:0007525 +name: somatic muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. This muscle is found in Nematodes." [GOC:jic, GOC:mtg_muscle] +is_a: GO:0007517 ! muscle development + +[Term] +id: GO:0007526 +name: larval somatic muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0007525 ! somatic muscle development +relationship: part_of GO:0002164 ! larval development + +[Term] +id: GO:0007527 +name: adult somatic muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0007525 ! somatic muscle development + +[Term] +id: GO:0007528 +name: neuromuscular junction development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neuromuscular junction over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0007529 +name: establishment of synaptic specificity at neuromuscular junction +namespace: biological_process +def: "The biological process by which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete] +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0007528 ! neuromuscular junction development + +[Term] +id: GO:0007530 +name: sex determination +namespace: biological_process +def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0003006 ! reproductive developmental process + +[Term] +id: GO:0007531 +name: mating type determination +namespace: biological_process +def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0007532 +name: regulation of transcription, mating-type specific +namespace: biological_process +def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription." [GOC:go_curators] +synonym: "mating-type specific transcriptional control" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0007531 ! mating type determination + +[Term] +id: GO:0007533 +name: mating type switching +namespace: biological_process +def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] +synonym: "mating type switching and recombination" RELATED [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0007531 ! mating type determination +is_a: GO:0022413 ! reproductive process in single-celled organism + +[Term] +id: GO:0007534 +name: gene conversion at mating-type locus +namespace: biological_process +def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492] +is_a: GO:0006312 ! mitotic recombination +relationship: part_of GO:0007533 ! mating type switching + +[Term] +id: GO:0007535 +name: donor selection +namespace: biological_process +def: "The process by which a cell uses one locus in preference to another as the donor in mating type switching." [GOC:mah, PMID:9928492] +synonym: "donor preference" RELATED [] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0007533 ! mating type switching + +[Term] +id: GO:0007536 +name: activation of recombination (HML) +namespace: biological_process +def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] +is_a: GO:0007535 ! donor selection +is_a: GO:0045911 ! positive regulation of DNA recombination + +[Term] +id: GO:0007537 +name: inactivation of recombination (HML) +namespace: biological_process +def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] +is_a: GO:0007535 ! donor selection +is_a: GO:0045910 ! negative regulation of DNA recombination + +[Term] +id: GO:0007538 +name: primary sex determination +namespace: biological_process +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0007539 +name: primary sex determination, soma +namespace: biological_process +def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] +is_a: GO:0007538 ! primary sex determination +relationship: part_of GO:0018993 ! somatic sex determination + +[Term] +id: GO:0007540 +name: sex determination, establishment of X:A ratio +namespace: biological_process +def: "The developmental process by which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete] +is_a: GO:0003006 ! reproductive developmental process +relationship: part_of GO:0007539 ! primary sex determination, soma + +[Term] +id: GO:0007541 +name: sex determination, primary response to X:A ratio +namespace: biological_process +def: "The developmental process by which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] +is_a: GO:0003006 ! reproductive developmental process +relationship: part_of GO:0007539 ! primary sex determination, soma + +[Term] +id: GO:0007542 +name: primary sex determination, germ-line +namespace: biological_process +def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems] +is_a: GO:0007538 ! primary sex determination +relationship: part_of GO:0018992 ! germ-line sex determination + +[Term] +id: GO:0007543 +name: sex determination, somatic-gonadal interaction +namespace: biological_process +def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete] +synonym: "sex determination, somatic/gonadal interaction" EXACT [] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0007542 ! primary sex determination, germ-line + +[Term] +id: GO:0007545 +name: processes downstream of sex determination signal +namespace: biological_process +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0007546 +name: somatic processes downstream of sex determination signal +namespace: biological_process +def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems] +is_a: GO:0007545 ! processes downstream of sex determination signal + +[Term] +id: GO:0007547 +name: germ-line processes downstream of sex determination signal +namespace: biological_process +def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems] +is_a: GO:0007545 ! processes downstream of sex determination signal +relationship: part_of GO:0018992 ! germ-line sex determination + +[Term] +id: GO:0007548 +name: sex differentiation +namespace: biological_process +def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] +is_a: GO:0003006 ! reproductive developmental process + +[Term] +id: GO:0007549 +name: dosage compensation +namespace: biological_process +def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0007550 +name: establishment of dosage compensation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] +comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. +is_obsolete: true +consider: GO:0007549 + +[Term] +id: GO:0007551 +name: maintenance of dosage compensation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] +comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. +is_obsolete: true +consider: GO:0007549 + +[Term] +id: GO:0007552 +name: metamorphosis +namespace: biological_process +alt_id: GO:0046698 +alt_id: GO:0046699 +def: "A biological process by which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. For example the change from tadpole to frog, and the change from larva to adult." [GOC:sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "metamorphosis (sensu Amphibia)" NARROW [] +synonym: "metamorphosis (sensu Insecta)" NARROW [] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0007553 +name: regulation of ecdysteroid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "regulation of ecdysteroid metabolism" EXACT [] +is_a: GO:0010565 ! regulation of ketone metabolic process +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0007554 +name: regulation of ecdysteroid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] +synonym: "regulation of ecdysteroid anabolism" EXACT [] +synonym: "regulation of ecdysteroid biosynthesis" EXACT [] +synonym: "regulation of ecdysteroid formation" EXACT [] +synonym: "regulation of ecdysteroid synthesis" EXACT [] +is_a: GO:0007553 ! regulation of ecdysteroid metabolic process +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0007555 +name: regulation of ecdysteroid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell or group of cells." [GOC:go_curators] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0045457 ! ecdysteroid secretion + +[Term] +id: GO:0007556 +name: regulation of juvenile hormone metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] +synonym: "regulation of juvenile hormone metabolism" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: part_of GO:0002165 ! instar larval or pupal development +relationship: regulates GO:0006716 ! juvenile hormone metabolic process + +[Term] +id: GO:0007557 +name: regulation of juvenile hormone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] +synonym: "regulation of juvenile hormone anabolism" EXACT [] +synonym: "regulation of juvenile hormone biosynthesis" EXACT [] +synonym: "regulation of juvenile hormone formation" EXACT [] +synonym: "regulation of juvenile hormone synthesis" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process + +[Term] +id: GO:0007558 +name: regulation of juvenile hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0045443 ! juvenile hormone secretion + +[Term] +id: GO:0007559 +name: histolysis +namespace: biological_process +def: "The breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:dph, GOC:ma] +is_a: GO:0016271 ! tissue death +relationship: part_of GO:0009888 ! tissue development + +[Term] +id: GO:0007560 +name: imaginal disc morphogenesis +namespace: biological_process +alt_id: GO:0007452 +def: "The process by which the anatomical structures derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jic] +synonym: "imaginal disc metamorphosis" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0007444 ! imaginal disc development +relationship: part_of GO:0007552 ! metamorphosis +relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis + +[Term] +id: GO:0007561 +name: imaginal disc eversion +namespace: biological_process +def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0007562 +name: eclosion +namespace: biological_process +def: "The emergence of an insect from a pupa-case or of a larva from an egg." [ISBN:0198600461] +is_a: GO:0035188 ! hatching + +[Term] +id: GO:0007563 +name: regulation of eclosion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007562 ! eclosion + +[Term] +id: GO:0007564 +name: regulation of chitin-based cuticle tanning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jic, GOC:mtg_sensu] +synonym: "regulation of cuticle hardening" NARROW [] +synonym: "regulation of cuticle tanning" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007593 ! chitin-based cuticle tanning + +[Term] +id: GO:0007565 +name: female pregnancy +namespace: biological_process +def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] +synonym: "carrying of young" RELATED [] +synonym: "gestation" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0007566 +name: embryo implantation +namespace: biological_process +def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com] +synonym: "blastocyst implantation" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development +relationship: part_of GO:0007565 ! female pregnancy + +[Term] +id: GO:0007567 +name: parturition +namespace: biological_process +def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "egg laying" NARROW [] +synonym: "giving birth" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0007568 +name: aging +namespace: biological_process +alt_id: GO:0016280 +def: "The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:ems] +synonym: "ageing" EXACT [] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0007569 +name: cell aging +namespace: biological_process +def: "Progression of the cell from its inception to the end of its lifespan." [GOC:jh, PMID:12044934] +synonym: "cell ageing" EXACT [] +synonym: "cell aging (sensu Fungi)" NARROW [] +synonym: "cell aging (sensu Saccharomyces)" NARROW [] +synonym: "cellular senescence" EXACT [] +is_a: GO:0007568 ! aging +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007570 +name: age dependent accumulation of genetic damage +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0001301 + +[Term] +id: GO:0007571 +name: age-dependent general metabolic decline +namespace: biological_process +def: "The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis." [GOC:jh, PMID:9891807] +synonym: "age-dependent decreased translational activity" NARROW [] +synonym: "age-dependent increased protein content" NARROW [] +synonym: "age-dependent yeast cell size increase" RELATED [] +synonym: "nucleolar size increase" RELATED [] +synonym: "nucleolar size increase (sensu Saccharomyces)" RELATED [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007568 ! aging + +[Term] +id: GO:0007572 +name: age dependent decreased translational activity +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0007571 + +[Term] +id: GO:0007573 +name: age dependent increased protein content +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0007571 + +[Term] +id: GO:0007574 +name: cell aging (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators] +comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. +is_obsolete: true +replaced_by: GO:0007569 + +[Term] +id: GO:0007575 +name: nucleolar size increase +namespace: biological_process +def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0007571 +consider: GO:0007576 + +[Term] +id: GO:0007576 +name: nucleolar fragmentation +namespace: biological_process +alt_id: GO:0046616 +synonym: "nucleolar fragmentation (sensu Saccharomyces)" NARROW [] +synonym: "nucleolar size increase" RELATED [] +synonym: "nucleolar size increase (sensu Saccharomyces)" RELATED [] +is_a: GO:0007000 ! nucleolus organization +relationship: part_of GO:0007569 ! cell aging + +[Term] +id: GO:0007577 +name: autophagic death (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators] +comment: This term was made obsolete because a more correct term has been created. +is_obsolete: true +consider: GO:0048102 + +[Term] +id: GO:0007578 +name: aging dependent sterility (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators] +comment: This term was made obsolete because it reflected a trait or phenotype. +is_obsolete: true +consider: GO:0030466 + +[Term] +id: GO:0007579 +name: senescence factor accumulation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jh] +comment: This term was made obsolete because it does not represent a process. +is_obsolete: true + +[Term] +id: GO:0007580 +name: extrachromosomal circular DNA accumulation during cell aging +namespace: biological_process +def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807] +comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. +synonym: "extrachromosomal circular DNA accumulation during cell ageing" EXACT [] +is_a: GO:0001301 ! progressive alteration of chromatin during cell aging + +[Term] +id: GO:0007581 +name: age-dependent yeast cell size increase +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0007571 + +[Term] +id: GO:0007583 +name: killer activity +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes. +is_obsolete: true +consider: GO:0042267 + +[Term] +id: GO:0007584 +name: response to nutrient +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] +subset: gosubset_prok +synonym: "nutritional response pathway" NARROW [] +synonym: "response to nutrients" EXACT [] +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0007585 +name: respiratory gaseous exchange +namespace: biological_process +def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "breathing" BROAD [] +synonym: "respiration" BROAD [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0007586 +name: digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0007587 +name: sugar utilization +namespace: biological_process +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0007588 +name: excretion +namespace: biological_process +def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] +subset: goslim_pir +is_a: GO:0003008 ! system process +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0007589 +name: body fluid secretion +namespace: biological_process +def: "The regulated release of a fluid by a cell or group of cells in a multicellular organism." [GOC:ai, GOC:dph, GOC:tb] +is_a: GO:0046903 ! secretion +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0007590 +name: fat body metabolic process (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body. +is_obsolete: true +consider: GO:0008152 +consider: GO:0015032 + +[Term] +id: GO:0007591 +name: molting cycle, chitin-based cuticle +namespace: biological_process +def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle." [GOC:jl, GOC:mtg_sensu] +synonym: "molting cycle (sensu Insecta)" EXACT [] +is_a: GO:0018988 ! molting cycle, protein-based cuticle + +[Term] +id: GO:0007592 +name: protein-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet." [GOC:ems, GOC:mtg_sensu] +synonym: "cuticle anabolism (sensu Protostomia and Nematoda)" EXACT [] +synonym: "cuticle biosynthetic process (sensu Protostomia and Nematoda)" EXACT [] +synonym: "cuticle formation (sensu Protostomia and Nematoda)" EXACT [] +synonym: "cuticle synthesis (sensu Protostomia and Nematoda)" EXACT [] +is_a: GO:0042335 ! cuticle development + +[Term] +id: GO:0007593 +name: chitin-based cuticle tanning +namespace: biological_process +alt_id: GO:0045452 +def: "The cross-linking of chitin and other cuticle proteins, rendering them insoluble and hardening the cuticle. This process generally darkens the color of the cuticle." [GOC:bf, GOC:jic, GOC:mtg_sensu] +synonym: "cuticle hardening" NARROW [] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0040006 ! protein-based cuticle attachment to epithelium +relationship: part_of GO:0008365 ! adult chitin-based cuticle development + +[Term] +id: GO:0007594 +name: puparial adhesion +namespace: biological_process +def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma] +synonym: "puparial glue (sensu Diptera)" RELATED [] +is_a: GO:0022609 ! multicellular organism adhesion to substrate +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0007595 +name: lactation +namespace: biological_process +def: "The secretion of milk by the mammary gland." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048609 ! reproductive process in a multicellular organism + +[Term] +id: GO:0007596 +name: blood coagulation +namespace: biological_process +def: "The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "blood clotting" EXACT [] +xref: Reactome:140875 +xref: Reactome:140877 +xref: Reactome:211647 +xref: Reactome:211988 +xref: Reactome:221419 +xref: Reactome:221752 +xref: Reactome:230054 +xref: Reactome:230334 +xref: Reactome:238072 +xref: Reactome:238370 +xref: Reactome:244684 +xref: Reactome:244925 +is_a: GO:0007599 ! hemostasis +is_a: GO:0050817 ! coagulation +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0007597 +name: blood coagulation, intrinsic pathway +namespace: biological_process +def: "A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. +xref: Reactome:140837 +xref: Reactome:211792 +xref: Reactome:221605 +xref: Reactome:230203 +xref: Reactome:238239 +is_a: GO:0007596 ! blood coagulation + +[Term] +id: GO:0007598 +name: blood coagulation, extrinsic pathway +namespace: biological_process +def: "A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. +xref: Reactome:140834 +xref: Reactome:211793 +xref: Reactome:221557 +xref: Reactome:230165 +xref: Reactome:238197 +is_a: GO:0007596 ! blood coagulation + +[Term] +id: GO:0007599 +name: hemostasis +namespace: biological_process +def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0007600 +name: sensory perception +namespace: biological_process +def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai, GOC:dph] +is_a: GO:0050890 ! cognition + +[Term] +id: GO:0007601 +name: visual perception +namespace: biological_process +def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] +synonym: "sense of sight" EXACT [] +synonym: "sensory visual perception" EXACT [] +synonym: "vision" EXACT [] +is_a: GO:0050953 ! sensory perception of light stimulus + +[Term] +id: GO:0007602 +name: phototransduction +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] +subset: gosubset_prok +synonym: "opsin" RELATED [] +synonym: "phototransduction, visible light, light adaptation" NARROW [] +synonym: "phototrophin mediated phototransduction" NARROW [] +is_a: GO:0050908 ! detection of light stimulus involved in visual perception +relationship: part_of GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0007603 +name: phototransduction, visible light +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0007602 ! phototransduction +relationship: part_of GO:0009584 ! detection of visible light + +[Term] +id: GO:0007604 +name: phototransduction, UV +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "phototransduction, ultraviolet light" EXACT [] +synonym: "phototransduction, ultraviolet radiation" EXACT [] +synonym: "phototransduction, UV light" EXACT [] +synonym: "phototransduction, UV radiation" EXACT [] +synonym: "UV-sensitive opsin" RELATED [] +is_a: GO:0007602 ! phototransduction +relationship: part_of GO:0009589 ! detection of UV + +[Term] +id: GO:0007605 +name: sensory perception of sound +namespace: biological_process +def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] +synonym: "hearing" EXACT [] +synonym: "perception of sound" EXACT [] +is_a: GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0007606 +name: sensory perception of chemical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "chemosensory perception" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0007607 +name: taste perception +namespace: biological_process +def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172] +comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. +is_obsolete: true +consider: GO:0050909 +consider: GO:0050912 + +[Term] +id: GO:0007608 +name: sensory perception of smell +namespace: biological_process +def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors." [GOC:ai, http://www.onelook.com/] +synonym: "olfaction" EXACT [] +synonym: "scent perception" EXACT [] +synonym: "sense of smell" EXACT [] +synonym: "smell perception" EXACT [] +is_a: GO:0007606 ! sensory perception of chemical stimulus + +[Term] +id: GO:0007610 +name: behavior +namespace: biological_process +def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:ems, ISBN:0395448956] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +synonym: "behavioral response to stimulus" EXACT [] +synonym: "behaviour" EXACT [] +synonym: "behavioural response to stimulus" EXACT [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0007611 +name: learning or memory +namespace: biological_process +def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jic, PMID:8938125] +is_a: GO:0007610 ! behavior +is_a: GO:0050890 ! cognition + +[Term] +id: GO:0007612 +name: learning +namespace: biological_process +def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0007611 ! learning or memory + +[Term] +id: GO:0007613 +name: memory +namespace: biological_process +def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [http://cancerweb.ncl.ac.uk/, http://www.onelook.com/, ISBN:0582227089] +is_a: GO:0007611 ! learning or memory + +[Term] +id: GO:0007614 +name: short-term memory +namespace: biological_process +def: "The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] +is_a: GO:0007613 ! memory + +[Term] +id: GO:0007615 +name: anesthesia-resistant memory +namespace: biological_process +is_a: GO:0007613 ! memory + +[Term] +id: GO:0007616 +name: long-term memory +namespace: biological_process +def: "The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] +is_a: GO:0007613 ! memory + +[Term] +id: GO:0007617 +name: mating behavior +namespace: biological_process +def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] +synonym: "mating behaviour" EXACT [] +is_a: GO:0019098 ! reproductive behavior +is_a: GO:0051705 ! behavioral interaction between organisms +relationship: part_of GO:0007618 ! mating + +[Term] +id: GO:0007618 +name: mating +namespace: biological_process +def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [ISBN:0387520546] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0007619 +name: courtship behavior +namespace: biological_process +def: "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] +synonym: "courtship behaviour" EXACT [] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0007620 +name: copulation +namespace: biological_process +def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0007618 ! mating + +[Term] +id: GO:0007621 +name: negative regulation of female receptivity +namespace: biological_process +def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827] +synonym: "down regulation of female receptivity" EXACT [] +synonym: "down-regulation of female receptivity" EXACT [] +synonym: "downregulation of female receptivity" EXACT [] +synonym: "inhibition of female receptivity" NARROW [] +is_a: GO:0045924 ! regulation of female receptivity +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0060181 ! female receptivity + +[Term] +id: GO:0007622 +name: rhythmic behavior +namespace: biological_process +def: "The specific actions or reactions of an organism that recur with measured regularity." [GOC:jl] +synonym: "rhythmic behavioral response to stimulus" EXACT [] +synonym: "rhythmic behaviour" EXACT [] +synonym: "rhythmic behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0048511 ! rhythmic process + +[Term] +id: GO:0007623 +name: circadian rhythm +namespace: biological_process +alt_id: GO:0050895 +def: "Any biological process in an organism that recur with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] +subset: gosubset_prok +synonym: "circadian process" EXACT [] +synonym: "circadian response" RELATED [] +synonym: "response to circadian rhythm" RELATED [] +is_a: GO:0048511 ! rhythmic process + +[Term] +id: GO:0007624 +name: ultradian rhythm +namespace: biological_process +def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0048511 ! rhythmic process + +[Term] +id: GO:0007625 +name: grooming behavior +namespace: biological_process +def: "The specific actions or reactions of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl] +synonym: "grooming behaviour" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0007626 +name: locomotory behavior +namespace: biological_process +def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] +subset: gosubset_prok +synonym: "locomotion in response to stimulus" EXACT [] +synonym: "locomotory behavioral response to stimulus" EXACT [] +synonym: "locomotory behaviour" EXACT [] +synonym: "locomotory behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0007627 +name: larval behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jic] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +is_obsolete: true +replaced_by: GO:0030537 + +[Term] +id: GO:0007628 +name: adult walking behavior +namespace: biological_process +def: "The actions or reactions of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jic, ISBN:0198606907] +synonym: "adult walking behaviour" EXACT [] +is_a: GO:0008344 ! adult locomotory behavior + +[Term] +id: GO:0007629 +name: flight behavior +namespace: biological_process +def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jic, ISBN:0198606907] +synonym: "flight behaviour" EXACT [] +is_a: GO:0008344 ! adult locomotory behavior + +[Term] +id: GO:0007630 +name: jump response +namespace: biological_process +def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jic, ISBN:0198606907] +is_a: GO:0008344 ! adult locomotory behavior + +[Term] +id: GO:0007631 +name: feeding behavior +namespace: biological_process +def: "Behavior associated with the intake of food." [GOC:mah] +comment: See also the biological process term 'behavior ; GO:0007610'. +synonym: "behavioral response to food" EXACT [] +synonym: "behavioural response to food" EXACT [] +synonym: "drinking" NARROW [] +synonym: "eating" NARROW [] +synonym: "feeding behaviour" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0007632 +name: visual behavior +namespace: biological_process +def: "The actions or reactions of an organism in response to a visual stimulus." [GOC:jic] +synonym: "behavioral response to visual stimulus" EXACT [] +synonym: "behavioural response to visual stimulus" EXACT [] +synonym: "visual behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0007633 +name: pattern orientation +namespace: biological_process +def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jic, PMID:9933535] +synonym: "behavioral response to pattern orientation" EXACT [] +synonym: "behavioural response to pattern orientation" EXACT [] +is_a: GO:0007632 ! visual behavior + +[Term] +id: GO:0007634 +name: optokinetic behavior +namespace: biological_process +def: "The actions or reactions of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jic, http://www.mercksource.com] +synonym: "optokinetic behaviour" EXACT [] +is_a: GO:0007632 ! visual behavior + +[Term] +id: GO:0007635 +name: chemosensory behavior +namespace: biological_process +def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] +synonym: "behavioral response to chemical stimulus" EXACT [] +synonym: "behavioural response to chemical stimulus" EXACT [] +synonym: "chemosensory behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0007636 +name: chemosensory jump behavior +namespace: biological_process +def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jic] +synonym: "chemosensory jump behaviour" EXACT [] +synonym: "jump response to chemical stimulus" EXACT [] +is_a: GO:0007630 ! jump response +is_a: GO:0007635 ! chemosensory behavior + +[Term] +id: GO:0007637 +name: proboscis extension reflex +namespace: biological_process +def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jic, http://fbserver.gen.cam.ac.uk] +synonym: "behavioral response to sugar stimulus, proboscis extension" EXACT [] +synonym: "proboscis extension in response to sugar stimulus" EXACT [] +is_a: GO:0007635 ! chemosensory behavior +is_a: GO:0051780 ! behavioral response to nutrient +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0007638 +name: mechanosensory behavior +namespace: biological_process +def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] +synonym: "behavioral response to mechanical stimulus" EXACT [] +synonym: "behavioural response to mechanical stimulus" EXACT [] +synonym: "mechanosensory behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0007639 +name: homeostasis of number of meristem cells +namespace: biological_process +def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells in the meristem." [GOC:isa_complete] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0008001 +name: fibrinogen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it does not describe an activity. +is_obsolete: true +replaced_by: GO:0005577 + +[Term] +id: GO:0008002 +name: lamina lucida +namespace: cellular_component +def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005605 ! basal lamina + +[Term] +id: GO:0008003 +name: lamina densa +namespace: cellular_component +def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005605 ! basal lamina + +[Term] +id: GO:0008004 +name: lamina reticularis +namespace: cellular_component +def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005605 ! basal lamina + +[Term] +id: GO:0008008 +name: membrane attack complex protein beta2 chain +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0005579 + +[Term] +id: GO:0008009 +name: chemokine activity +namespace: molecular_function +def: "The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation." [http://www.copewithcytokines.de/cope.cgi?001252] +comment: See also the molecular function term 'cytokine activity ; GO:0005125'. +is_a: GO:0005125 ! cytokine activity +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0008010 +name: structural constituent of chitin-based larval cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of larval cuticle (sensu Insecta)" EXACT [] +is_a: GO:0005214 ! structural constituent of chitin-based cuticle + +[Term] +id: GO:0008011 +name: structural constituent of pupal chitin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of pupal cuticle (sensu Insecta)" EXACT [] +is_a: GO:0005214 ! structural constituent of chitin-based cuticle + +[Term] +id: GO:0008012 +name: structural constituent of adult chitin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of adult cuticle (sensu Insecta)" EXACT [] +is_a: GO:0005214 ! structural constituent of chitin-based cuticle + +[Term] +id: GO:0008013 +name: beta-catenin binding +namespace: molecular_function +def: "Interacting selectively with the beta subunit of the catenin complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008014 +name: calcium-dependent cell adhesion molecule activity +namespace: molecular_function +alt_id: GO:0001538 +def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +synonym: "cadherin" NARROW [] +is_obsolete: true +replaced_by: GO:0005515 +replaced_by: GO:0016021 +replaced_by: GO:0016339 + +[Term] +id: GO:0008015 +name: blood circulation +namespace: biological_process +def: "The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products." [ISBN:0192800825] +subset: goslim_pir +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0008016 +name: regulation of heart contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of cardiac contraction" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0060047 ! heart contraction + +[Term] +id: GO:0008017 +name: microtubule binding +namespace: molecular_function +def: "Interacting selectively with microtubules, filaments composed of tubulin monomers." [GOC:krc] +synonym: "microtubule severing activity" RELATED [] +synonym: "microtubule/chromatin interaction" RELATED [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0008018 +name: structural protein of chorion (sensu Drosophila) +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the function is covered by a parent term. +is_obsolete: true +replaced_by: GO:0005213 + +[Term] +id: GO:0008019 +name: macrophage receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its name is ambiguous, and it was never defined. +is_obsolete: true +consider: GO:0005044 +consider: GO:0008329 + +[Term] +id: GO:0008020 +name: G-protein coupled photoreceptor activity +namespace: molecular_function +alt_id: GO:0004975 +def: "A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "G protein coupled photoreceptor activity" EXACT [] +synonym: "G-protein-coupled photoreceptor activity" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity +is_a: GO:0009881 ! photoreceptor activity + +[Term] +id: GO:0008021 +name: synaptic vesicle +namespace: cellular_component +def: "Secretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] +is_a: GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0008022 +name: protein C-terminus binding +namespace: molecular_function +def: "Interacting selectively with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "C-terminal binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008023 +name: transcription elongation factor complex +namespace: cellular_component +def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0008024 +name: transcription elongation factor complex b +namespace: cellular_component +def: "A complex of cyclin T and a cyclin-dependent protein kinase, catalyst, that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme." [UniProtKB:O60563] +comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0008025 +name: diazepam binding inhibitor activity +namespace: molecular_function +def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11883709] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "DBI" EXACT [] +synonym: "diazepam-binding inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0004857 +consider: GO:0030156 +consider: GO:0050796 +consider: GO:0050809 +consider: GO:0050810 +consider: GO:0050811 +consider: GO:0050812 + +[Term] +id: GO:0008026 +name: ATP-dependent helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0042623 ! ATPase activity, coupled +is_a: GO:0070035 ! purine NTP-dependent helicase activity + +[Term] +id: GO:0008028 +name: monocarboxylic acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0008505 +def: "Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] +subset: gosubset_prok +synonym: "monocarboxylate carrier" NARROW [] +synonym: "prostaglandin/thromboxane transporter activity" NARROW [] +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0008029 +name: pentraxin receptor activity +namespace: molecular_function +def: "Combining with a pentraxin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). +synonym: "pentaxin receptor" EXACT [] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0001864 ! pentraxin binding + +[Term] +id: GO:0008030 +name: neuronal pentraxin receptor activity +namespace: molecular_function +synonym: "neuronal pentaxin receptor" EXACT [] +is_a: GO:0008029 ! pentraxin receptor activity + +[Term] +id: GO:0008031 +name: eclosion hormone activity +namespace: molecular_function +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0008033 +name: tRNA processing +namespace: biological_process +def: "The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] +subset: gosubset_prok +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0008034 +name: lipoprotein binding +namespace: molecular_function +def: "Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008035 +name: high-density lipoprotein binding +namespace: molecular_function +def: "Interacting selectively with high-density lipoprotein: one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008034 ! lipoprotein binding + +[Term] +id: GO:0008036 +name: diuretic hormone receptor activity +namespace: molecular_function +def: "Combining with a diuretic hormone to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0008037 +name: cell recognition +namespace: biological_process +def: "The process by which a cell in a multicellular organism interprets its surroundings." [GOC:go_curators] +subset: goslim_generic +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0008038 +name: neuron recognition +namespace: biological_process +def: "The process by which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] +synonym: "neuronal cell recognition" EXACT [] +is_a: GO:0008037 ! cell recognition + +[Term] +id: GO:0008039 +name: synaptic target recognition +namespace: biological_process +def: "The process by which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] +synonym: "neuronal targeting" EXACT [] +is_a: GO:0008038 ! neuron recognition + +[Term] +id: GO:0008041 +name: storage protein of fat body (sensu Insecta) +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular location rather than a function. +is_obsolete: true +replaced_by: GO:0045735 + +[Term] +id: GO:0008042 +name: iron-sulfur electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "ferredoxin" NARROW [] +synonym: "iron-sulphur electron transfer carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0008043 +name: ferritin complex +namespace: cellular_component +def: "A iron-storing protein complex, which in humans has 24 subunits. There are two different ferritin subunits, the L (light) chain and H (heavy) chain." [GOC:jl, UniProtKB:P02792] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0008044 +name: adult behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jic] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +is_obsolete: true +replaced_by: GO:0030534 + +[Term] +id: GO:0008045 +name: motor axon guidance +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0008046 +name: axon guidance receptor activity +namespace: molecular_function +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0008047 +name: enzyme activator activity +namespace: molecular_function +def: "Increases the activity of an enzyme." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0008048 +name: calcium sensitive guanylate cyclase activator activity +namespace: molecular_function +is_a: GO:0030250 ! guanylate cyclase activator activity + +[Term] +id: GO:0008049 +name: male courtship behavior +namespace: biological_process +alt_id: GO:0016542 +def: "The actions or reactions of a male, for the purpose of attracting a sexual partner." [GOC:mtg_sensu] +synonym: "male courtship behavior (sensu Insecta)" EXACT [] +synonym: "male courtship behaviour" EXACT [] +synonym: "male courtship behaviour (sensu Insecta)" EXACT [] +is_a: GO:0060179 ! male mating behavior +relationship: part_of GO:0007619 ! courtship behavior + +[Term] +id: GO:0008050 +name: female courtship behavior +namespace: biological_process +def: "The actions or reactions of a female, for the purpose of attracting a sexual partner." [GOC:bf] +synonym: "female courtship behaviour" EXACT [] +is_a: GO:0060180 ! female mating behavior +relationship: part_of GO:0007619 ! courtship behavior + +[Term] +id: GO:0008051 +name: farnesyl-diphosphate farnesyl transferase complex +namespace: cellular_component +def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah] +comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. +is_obsolete: true +consider: GO:0004310 + +[Term] +id: GO:0008052 +name: sensory organ boundary specification +namespace: biological_process +def: "The process by which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "sense organ boundary specification" EXACT [GOC:dph] +is_a: GO:0010160 ! formation of organ boundary +relationship: part_of GO:0007423 ! sensory organ development + +[Term] +id: GO:0008053 +name: mitochondrial fusion +namespace: biological_process +def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] +is_a: GO:0006944 ! membrane fusion +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0048284 ! organelle fusion + +[Term] +id: GO:0008054 +name: cyclin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, http://cancerweb.ncl.ac.uk/] +synonym: "cyclin breakdown" EXACT [] +synonym: "cyclin catabolism" EXACT [] +synonym: "cyclin degradation" EXACT [] +synonym: "degradation of cyclin" EXACT [] +is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0008055 +name: ocellus pigment biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "ocellus pigment anabolism" EXACT [] +synonym: "ocellus pigment biosynthesis" EXACT [] +synonym: "ocellus pigment formation" EXACT [] +synonym: "ocellus pigment synthesis" EXACT [] +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0046158 ! ocellus pigment metabolic process + +[Term] +id: GO:0008056 +name: ocellus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035214 ! eye-antennal disc development + +[Term] +id: GO:0008057 +name: eye pigment granule organization +namespace: biological_process +alt_id: GO:0008059 +alt_id: GO:0045318 +alt_id: GO:0048751 +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] +synonym: "eye pigment granule organization and biogenesis" EXACT [] +is_a: GO:0048753 ! pigment granule organization + +[Term] +id: GO:0008058 +name: ocellus pigment granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm] +synonym: "ocellus pigment granule organisation and biogenesis" EXACT [] +synonym: "ocellus pigment granule organization and biogenesis" EXACT [] +is_a: GO:0048753 ! pigment granule organization + +[Term] +id: GO:0008060 +name: ARF GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0005096 ! GTPase activator activity + +[Term] +id: GO:0008061 +name: chitin binding +namespace: molecular_function +def: "Interacting selectively with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0008062 +name: eclosion rhythm +namespace: biological_process +def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] +is_a: GO:0048512 ! circadian behavior +relationship: part_of GO:0007562 ! eclosion + +[Term] +id: GO:0008063 +name: Toll signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to an extracellular ligand to the Toll receptor on the surface of the target cell." [GOC:go_curators] +synonym: "Tl signaling pathway" EXACT [] +synonym: "Tl signalling pathway" EXACT [] +synonym: "Toll signalling pathway" EXACT [] +xref: Reactome:166016 +xref: Reactome:211663 +xref: Reactome:221435 +xref: Reactome:230067 +xref: Reactome:238087 +xref: Reactome:273985 +xref: Reactome:280464 +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0008064 +name: regulation of actin polymerization or depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] +is_a: GO:0030832 ! regulation of actin filament length +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0008154 ! actin polymerization or depolymerization + +[Term] +id: GO:0008065 +name: establishment of blood-nerve barrier +namespace: biological_process +def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] +synonym: "establishment of blood/nerve barrier" EXACT [] +is_a: GO:0001885 ! endothelial cell development +relationship: part_of GO:0007422 ! peripheral nervous system development + +[Term] +id: GO:0008066 +name: glutamate receptor activity +namespace: molecular_function +def: "Combining with glutamate to initiate a change in cell activity." [GOC:ai] +subset: gosubset_prok +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0008067 +name: metabotropic glutamate, GABA-B-like receptor activity +namespace: molecular_function +alt_id: GO:0001643 +alt_id: GO:0001645 +def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285] +comment: This term was made obsolete because it represents a gene product and is named based on protein features. +synonym: "class C G protein coupled receptor" BROAD [] +synonym: "class C G-protein coupled receptor" BROAD [] +synonym: "class C GPCR" BROAD [] +synonym: "class C orphan receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0008068 +name: extracellular-glutamate-gated chloride channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. +is_a: GO:0005234 ! extracellular-glutamate-gated ion channel activity +is_a: GO:0005254 ! chloride channel activity + +[Term] +id: GO:0008069 +name: dorsal/ventral axis specification, ovarian follicular epithelium +namespace: biological_process +def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] +synonym: "dorsal/ventral axis determination, follicular epithelium (sensu Insecta)" EXACT [] +synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009950 ! dorsal/ventral axis specification +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0008070 +name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded +namespace: biological_process +def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238] +is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium + +[Term] +id: GO:0008071 +name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded +namespace: biological_process +def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta)" EXACT [] +is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium + +[Term] +id: GO:0008073 +name: ornithine decarboxylase inhibitor activity +namespace: molecular_function +def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0042979 ! ornithine decarboxylase regulator activity + +[Term] +id: GO:0008074 +name: guanylate cyclase complex, soluble +namespace: cellular_component +def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] +comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0008075 +name: receptor guanylate cyclase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0004383 +consider: GO:0004872 + +[Term] +id: GO:0008076 +name: voltage-gated potassium channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] +subset: gosubset_prok +synonym: "voltage gated potassium channel complex" EXACT [] +synonym: "voltage-dependent potassium channel complex" EXACT [] +synonym: "voltage-sensitive potassium channel complex" EXACT [] +is_a: GO:0034705 ! potassium channel complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0008077 +name: Hsp70/Hsp90 organizing protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:rb] +comment: This term was made obsolete because it represents a specific gene product rather than a molecular function. +synonym: "Hsp70/Hsp90 organising protein activity" EXACT [] +is_obsolete: true +consider: GO:0030674 + +[Term] +id: GO:0008078 +name: mesodermal cell migration +namespace: biological_process +def: "The orderly movement of mesodermal cells from one site to another." [GOC:mah] +synonym: "mesoderm cell migration" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007509 ! mesoderm migration + +[Term] +id: GO:0008079 +name: translation termination factor activity +namespace: molecular_function +def: "Functions in the termination of translation." [GOC:ma] +subset: gosubset_prok +is_a: GO:0008135 ! translation factor activity, nucleic acid binding + +[Term] +id: GO:0008080 +name: N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0016407 ! acetyltransferase activity +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0008081 +name: phosphoric diester hydrolase activity +namespace: molecular_function +alt_id: GO:0016792 +def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "endonuclease VIII activity" RELATED [] +synonym: "phosphodiesterase" NARROW [] +xref: EC:3.1.4 +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0008083 +name: growth factor activity +namespace: molecular_function +def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0008084 +name: imaginal disc growth factor activity +namespace: molecular_function +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0008085 +name: phototransduction, visible light, light adaptation +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term name is ambiguous. +is_obsolete: true +consider: GO:0007602 + +[Term] +id: GO:0008086 +name: light-activated voltage-gated calcium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light." [GOC:mtg_transport] +synonym: "light-activated voltage gated calcium channel activity" EXACT [] +synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] +is_a: GO:0005245 ! voltage-gated calcium channel activity +is_a: GO:0010461 ! light-activated channel activity + +[Term] +id: GO:0008087 +name: light-activated voltage-gated calcium channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] +synonym: "light-activated voltage gated calcium channel complex" EXACT [] +synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] +synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] +is_a: GO:0005891 ! voltage-gated calcium channel complex + +[Term] +id: GO:0008088 +name: axon cargo transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] +synonym: "axonal transport" EXACT [] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0008089 +name: anterograde axon cargo transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] +synonym: "anterograde axonal transport" EXACT [] +is_a: GO:0008088 ! axon cargo transport + +[Term] +id: GO:0008090 +name: retrograde axon cargo transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] +synonym: "retrograde axonal transport" RELATED [] +is_a: GO:0008088 ! axon cargo transport + +[Term] +id: GO:0008091 +name: spectrin +namespace: cellular_component +def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0008092 +name: cytoskeletal protein binding +namespace: molecular_function +def: "Interacting selectively with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] +subset: goslim_generic +subset: gosubset_prok +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008093 +name: cytoskeletal adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a cytoskeletal molecule and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +is_a: GO:0008092 ! cytoskeletal protein binding +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0008094 +name: DNA-dependent ATPase activity +namespace: molecular_function +alt_id: GO:0004011 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] +synonym: "DNA dependent ATPase activity" EXACT [] +synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] +is_a: GO:0042623 ! ATPase activity, coupled + +[Term] +id: GO:0008095 +name: inositol-1,4,5-triphosphate receptor activity +namespace: molecular_function +def: "Combining with inositol-1,4,5-triphosphate to initiate a change in cell activity." [GOC:ai] +synonym: "IP3 receptor activity" EXACT [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0008096 +name: juvenile hormone epoxide hydrolase activity +namespace: molecular_function +xref: EC:3.3.2.- +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0008097 +name: 5S rRNA binding +namespace: molecular_function +def: "Interacting selectively with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] +subset: gosubset_prok +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0008098 +name: 5S rRNA primary transcript binding +namespace: molecular_function +def: "Interacting selectively with the unprocessed 5S ribosomal RNA transcript." [GOC:jl] +is_a: GO:0008097 ! 5S rRNA binding + +[Term] +id: GO:0008100 +name: lipophorin +namespace: molecular_function +def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0008101 +name: decapentaplegic receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:ai] +synonym: "decapentaplegic receptor signalling pathway" EXACT [] +synonym: "dpp receptor signaling pathway" EXACT [] +synonym: "dpp receptor signalling pathway" EXACT [] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0008103 +name: oocyte microtubule cytoskeleton polarization +namespace: biological_process +alt_id: GO:0048129 +def: "Establishment and maintenance of an axis of polarity of the oocyte microtubule network such that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively." [GOC:mtg_sensu, PMID:11807042] +synonym: "oocyte microtubule cytoskeleton polarization (sensu Insecta)" RELATED [] +is_a: GO:0007017 ! microtubule-based process +relationship: part_of GO:0007309 ! oocyte axis specification +relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization + +[Term] +id: GO:0008104 +name: protein localization +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained in, a specific location." [GOC:ai] +subset: gosubset_prok +synonym: "establishment and maintenance of protein localization" EXACT [] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0008105 +name: asymmetric protein localization +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained in, a specific asymmetric distribution." [GOC:ma] +subset: gosubset_prok +synonym: "establishment and maintenance of asymmetric protein localization" EXACT [] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0008106 +name: alcohol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] +subset: gosubset_prok +synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2] +synonym: "aldehyde reductase (NADPH2)" EXACT [] +synonym: "NADP-aldehyde reductase activity" EXACT [] +xref: EC:1.1.1.2 +xref: MetaCyc:ALCOHOL-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0004033 ! aldo-keto reductase activity + +[Term] +id: GO:0008107 +name: galactoside 2-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] +subset: gosubset_prok +synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] +synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] +synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] +xref: EC:2.4.1.69 +xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN +is_a: GO:0031127 ! alpha(1,2)-fucosyltransferase activity + +[Term] +id: GO:0008108 +name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose." [EC:2.7.7.12] +subset: gosubset_prok +synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] +synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] +synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] +synonym: "uridyltransferase activity" EXACT [EC:2.7.7.12] +synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] +xref: EC:2.7.7.12 +xref: MetaCyc:GALACTURIDYLYLTRANS-RXN +xref: Reactome:22869 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008109 +name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] +synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] +synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] +synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150] +synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] +xref: EC:2.4.1.150 +xref: MetaCyc:2.4.1.150-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008110 +name: histidine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidine + 2-oxoglutarate = imidazol-5-yl-pyruvate + L-glutamate." [EC:2.6.1.38] +synonym: "histidine aminotransferase activity" EXACT [] +synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] +synonym: "L-histidine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] +xref: EC:2.6.1.38 +xref: MetaCyc:HISTTRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0008111 +name: alpha-methylacyl-CoA racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] +subset: gosubset_prok +synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4] +xref: EC:5.1.99.4 +xref: MetaCyc:5.1.99.4-RXN +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0008112 +name: nicotinamide N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide." [EC:2.1.1.1] +subset: gosubset_prok +synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1] +synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1] +xref: EC:2.1.1.1 +xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN +xref: Reactome:22892 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008113 +name: peptide-methionine-(S)-S-oxide reductase activity +namespace: molecular_function +alt_id: GO:0033742 +def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.11, PMID:11169920] +subset: gosubset_prok +synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11] +synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] +synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] +synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11] +synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] +synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11] +synonym: "MsrA" RELATED [EC:1.8.4.11] +synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11] +synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11] +synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11] +synonym: "protein-methionine-S-oxide reductase activity" EXACT [EC:1.8.4.11] +xref: EC:1.8.4.11 +xref: MetaCyc:PROTEIN-METHIONINE-S-OXIDE-REDUCTASE-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0008114 +name: phosphogluconate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] +synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43] +synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43] +synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] +synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43] +synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] +synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43] +synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43] +xref: EC:1.1.1.43 +xref: MetaCyc:1.1.1.43-RXN +xref: Reactome:22895 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008115 +name: sarcosine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: sarcosine + H2O + O2 = glycine + formaldehyde + H2O2." [EC:1.5.3.1] +subset: gosubset_prok +synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1] +xref: EC:1.5.3.1 +xref: MetaCyc:SARCOX-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0008116 +name: prostaglandin-I synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate." [EC:5.3.99.4] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4] +synonym: "cytochrome P450 CYP8A1" NARROW [] +synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4] +synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4] +synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4] +synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4] +synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4] +synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4] +synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4] +xref: EC:5.3.99.4 +xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN +xref: Reactome:22900 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0008117 +name: sphinganine-1-phosphate aldolase activity +namespace: molecular_function +alt_id: GO:0016001 +def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] +subset: gosubset_prok +synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27] +synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27] +synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] +xref: EC:4.1.2.27 +xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008118 +name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6] +synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6] +synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6] +synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6] +synonym: "SiaT" RELATED [EC:2.4.99.6] +xref: EC:2.4.99.6 +xref: MetaCyc:2.4.99.6-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0008119 +name: thiopurine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] +subset: gosubset_prok +synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67] +synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67] +synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67] +synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67] +synonym: "TPMT" RELATED [EC:2.1.1.67] +xref: EC:2.1.1.67 +xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN +xref: Reactome:22905 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008120 +name: ceramide glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] +subset: gosubset_prok +synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80] +synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80] +synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80] +synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] +synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] +synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] +synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] +synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] +xref: EC:2.4.1.80 +xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0008121 +name: ubiquinol-cytochrome-c reductase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c." [EC:1.10.2.2, ISBN:0198547684] +subset: gosubset_prok +synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] +synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] +synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] +synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "cytochrome bc1 complex" RELATED [] +synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] +synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] +synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] +synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] +synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] +synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] +synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] +xref: EC:1.10.2.2 +xref: MetaCyc:1.10.2.2-RXN +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor + +[Term] +id: GO:0008123 +name: cholesterol 7-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17] +synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] +synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17] +synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17] +synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17] +synonym: "cytochrome P450 CYP7A1" NARROW [] +xref: EC:1.14.13.17 +xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008124 +name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96] +subset: gosubset_prok +synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] +synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] +synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] +synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96] +synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] +synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] +synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] +synonym: "pterin-4alpha-carbinolamine dehydratase activity" EXACT [EC:4.2.1.96] +synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96] +xref: EC:4.2.1.96 +xref: MetaCyc:4.2.1.96-RXN +xref: Reactome:22934 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008125 +name: pancreatic elastase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36] +comment: This term was made obsolete because it represents a gene product. +synonym: "elaszym" RELATED [EC:3.4.21.36] +synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] +synonym: "serine elastase" BROAD [EC:3.4.21.36] +xref: EC:3.4.21.36 +xref: MetaCyc:3.4.21.36-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008126 +name: acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] +subset: gosubset_prok +synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6] +synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6] +synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] +synonym: "chloroesterase" NARROW [EC:3.1.1.6] +synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] +synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] +xref: EC:3.1.1.6 +xref: MetaCyc:ACETYLESTERASE-RXN +xref: UM-BBD_enzymeID:e0052 +is_a: GO:0034338 ! short-chain carboxylesterase activity + +[Term] +id: GO:0008127 +name: quercetin 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin + O2 = 2-protocatechuoylphloroglucinolcarboxylate + CO." [EC:1.13.11.24] +synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24] +synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24] +synonym: "quercetinase activity" EXACT [EC:1.13.11.24] +xref: EC:1.13.11.24 +xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0559 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0008129 +name: actinidain activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] +comment: This term was made obsolete because it represents a gene product. +synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] +synonym: "actinidin activity" EXACT [EC:3.4.22.14] +synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] +xref: EC:3.4.22.14 +xref: MetaCyc:3.4.22.14-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0008130 +name: neutrophil collagenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] +synonym: "MMP-8" EXACT [] +synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] +xref: EC:3.4.24.34 +xref: MetaCyc:3.4.24.34-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008131 +name: amine oxidase activity +namespace: molecular_function +alt_id: GO:0004041 +alt_id: GO:0008122 +def: "Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2." [EC:1.4.3.4, EC:1.4.3.6] +subset: gosubset_prok +synonym: "adrenalin oxidase" NARROW [EC:1.4.3.4] +synonym: "adrenaline oxidase activity" NARROW [EC:1.4.3.4] +synonym: "amine oxidase (copper-containing) activity" NARROW [] +synonym: "amine oxidase (flavin-containing) activity" NARROW [] +synonym: "amine oxidase (pyridoxal containing)" NARROW [EC:1.4.3.4] +synonym: "amine oxygen oxidoreductase activity" EXACT [EC:1.4.3.4] +synonym: "amine:oxygen oxidoreductase (deaminating) (copper-containing)" NARROW [EC:1.4.3.6] +synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing)" NARROW [EC:1.4.3.4] +synonym: "benzylamine oxidase" NARROW [EC:1.4.3.4] +synonym: "Cu-amine oxidase activity" NARROW [EC:1.4.3.6] +synonym: "DAO activity" NARROW [EC:1.4.3.4] +synonym: "diamine oxidase activity" NARROW [EC:1.4.3.6] +synonym: "diamine:O2 oxidoreductase (deaminating)" NARROW [EC:1.4.3.6] +synonym: "diamino oxhydrase activity" NARROW [EC:1.4.3.4] +synonym: "epinephrine oxidase" NARROW [EC:1.4.3.4] +synonym: "histaminase activity" NARROW [EC:1.4.3.6] +synonym: "histamine deaminase" NARROW [EC:1.4.3.6] +synonym: "histamine oxidase" NARROW [EC:1.4.3.6] +synonym: "MAO" RELATED [EC:1.4.3.4] +synonym: "monoamine oxidase activity" NARROW [EC:1.4.3.4] +synonym: "monoamine:O2 oxidoreductase (deaminating)" NARROW [EC:1.4.3.4] +synonym: "semicarbazide-sensitive amine oxidase" NARROW [EC:1.4.3.6] +synonym: "serotonin deaminase" NARROW [EC:1.4.3.4] +synonym: "spermidine oxidase" NARROW [EC:1.4.3.4] +synonym: "spermine oxidase" NARROW [EC:1.4.3.4] +synonym: "SSAO" RELATED [EC:1.4.3.4] +synonym: "tyraminase activity" NARROW [EC:1.4.3.4] +synonym: "tyramine oxidase activity" NARROW [EC:1.4.3.4] +xref: EC:1.4.3.4 +xref: EC:1.4.3.6 +xref: MetaCyc:AMINE-OXIDASE-(FLAVIN-CONTAINING)-RXN +xref: MetaCyc:AMINEOXID-RXN +xref: Reactome:7141 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0008132 +name: pancreatic elastase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.21.- +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008133 +name: collagenase activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.24.- +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008134 +name: transcription factor binding +namespace: molecular_function +def: "Interacting selectively with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "TF binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008135 +name: translation factor activity, nucleic acid binding +namespace: molecular_function +def: "Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome." [GOC:ai] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0003676 ! nucleic acid binding +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0008137 +name: NADH dehydrogenase (ubiquinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] +subset: gosubset_prok +synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3] +synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3] +synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3] +synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3] +synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3] +synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] +synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] +synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] +synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3] +synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3] +synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3] +synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] +synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3] +synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] +synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3] +synonym: "ubiquinone reductase activity" EXACT [] +xref: EC:1.6.5.3 +xref: MetaCyc:NADH-DEHYDROG-RXN +xref: Reactome:22973 +is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity + +[Term] +id: GO:0008138 +name: protein tyrosine/serine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate." [GOC:mah] +subset: gosubset_prok +synonym: "dual-specificity protein phosphatase" BROAD [] +xref: EC:3.1.3.- +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0008139 +name: nuclear localization sequence binding +namespace: molecular_function +def: "Interacting selectively with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] +synonym: "NLS binding" EXACT [] +synonym: "nuclear localization signal binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0008140 +name: cAMP response element binding protein binding +namespace: molecular_function +synonym: "3',5' cAMP response element binding protein binding" EXACT [] +synonym: "3',5'-cAMP response element binding protein binding" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] +synonym: "cyclic AMP response element binding protein binding" EXACT [] +is_a: GO:0003713 ! transcription coactivator activity + +[Term] +id: GO:0008141 +name: puparial glue (sensu Diptera) +namespace: molecular_function +def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +replaced_by: GO:0005198 +replaced_by: GO:0007594 + +[Term] +id: GO:0008142 +name: oxysterol binding +namespace: molecular_function +def: "Interacting selectively with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/] +is_a: GO:0032934 ! sterol binding + +[Term] +id: GO:0008143 +name: poly(A) binding +namespace: molecular_function +def: "Interacting selectively with the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "poly-A binding" EXACT [] +synonym: "polyadenylate binding" EXACT [] +is_a: GO:0003727 ! single-stranded RNA binding +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0008144 +name: drug binding +namespace: molecular_function +def: "Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0008145 +name: phenylalkylamine binding +namespace: molecular_function +def: "Interacting selectively with phenylalkylamine or any of its derivatives." [GOC:jl] +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0008146 +name: sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "sulphotransferase activity" EXACT [] +xref: EC:2.8.2 +xref: Reactome:2397 +is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups + +[Term] +id: GO:0008147 +name: structural constituent of bone +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0008148 +name: negative transcription elongation factor activity +namespace: molecular_function +def: "Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] +is_a: GO:0003711 ! transcription elongation regulator activity + +[Term] +id: GO:0008149 +name: para-aminobenzoic acid (PABA) synthase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX] +comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. +is_obsolete: true +consider: GO:0008696 +consider: GO:0046820 + +[Term] +id: GO:0008150 +name: biological_process +namespace: biological_process +alt_id: GO:0000004 +alt_id: GO:0007582 +def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete] +comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "biological process" EXACT [] +synonym: "biological process unknown" NARROW [] +synonym: "physiological process" EXACT [] + +[Term] +id: GO:0008152 +name: metabolic process +namespace: biological_process +def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] +comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "metabolic process resulting in cell growth" NARROW [] +synonym: "metabolism" EXACT [] +synonym: "metabolism resulting in cell growth" NARROW [] +xref: Reactome:212093 +xref: Reactome:221851 +xref: Reactome:230419 +xref: Reactome:238461 +xref: Reactome:245002 +xref: Reactome:249887 +xref: Reactome:252604 +xref: Reactome:255791 +xref: Reactome:259186 +xref: Reactome:262542 +xref: Reactome:265367 +xref: Reactome:268496 +xref: Reactome:274223 +xref: Reactome:280692 +xref: Reactome:282903 +xref: Reactome:286711 +xref: Reactome:288374 +xref: Reactome:289882 +xref: Reactome:290414 +xref: Reactome:291791 +xref: Reactome:292439 +xref: Reactome:293772 +xref: Reactome:71408 +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0008153 +name: para-aminobenzoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743] +subset: gosubset_prok +synonym: "4-aminobenzoic acid biosynthesis" EXACT [] +synonym: "4-aminobenzoic acid biosynthetic process" EXACT [] +synonym: "p-aminobenzoic acid biosynthesis" EXACT [] +synonym: "p-aminobenzoic acid biosynthetic process" EXACT [] +synonym: "PABA biosynthesis" EXACT [] +synonym: "PABA biosynthetic process" EXACT [] +synonym: "para-aminobenzoic acid anabolism" EXACT [] +synonym: "para-aminobenzoic acid biosynthesis" EXACT [] +synonym: "para-aminobenzoic acid formation" EXACT [] +synonym: "para-aminobenzoic acid synthesis" EXACT [] +synonym: "vitamin Bx biosynthesis" EXACT [] +synonym: "vitamin Bx biosynthetic process" EXACT [] +is_a: GO:0009396 ! folic acid and derivative biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046482 ! para-aminobenzoic acid metabolic process + +[Term] +id: GO:0008154 +name: actin polymerization or depolymerization +namespace: biological_process +def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] +is_a: GO:0007015 ! actin filament organization +is_a: GO:0034621 ! cellular macromolecular complex subunit organization + +[Term] +id: GO:0008155 +name: larval behavior (sensu Drosophila) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. +is_obsolete: true +replaced_by: GO:0030537 + +[Term] +id: GO:0008156 +name: negative regulation of DNA replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] +subset: gosubset_prok +synonym: "DNA replication inhibitor" RELATED [] +synonym: "down regulation of DNA replication" EXACT [] +synonym: "down-regulation of DNA replication" EXACT [] +synonym: "downregulation of DNA replication" EXACT [] +synonym: "inhibition of DNA replication" NARROW [] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0006260 ! DNA replication + +[Term] +id: GO:0008157 +name: protein phosphatase 1 binding +namespace: molecular_function +def: "Interacting selectively with the enzyme protein phosphatase 1." [GOC:jl] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:0008158 +name: hedgehog receptor activity +namespace: molecular_function +def: "Combining with the hedgehog protein to initiate a change in cell activity." [GOC:go_curators] +synonym: "patched activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0008159 +name: positive transcription elongation factor activity +namespace: molecular_function +def: "Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] +is_a: GO:0003711 ! transcription elongation regulator activity + +[Term] +id: GO:0008160 +name: protein tyrosine phosphatase activator activity +namespace: molecular_function +def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0019211 ! phosphatase activator activity + +[Term] +id: GO:0008161 +name: carbamate resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046681 + +[Term] +id: GO:0008162 +name: cyclodiene resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046682 + +[Term] +id: GO:0008163 +name: DDT resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046680 + +[Term] +id: GO:0008164 +name: organophosphorus resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046683 + +[Term] +id: GO:0008165 +name: pyrethroid resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046684 + +[Term] +id: GO:0008166 +name: viral replication +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms. +is_obsolete: true +consider: GO:0019079 + +[Term] +id: GO:0008167 +name: sigma virus replication +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +is_obsolete: true +replaced_by: GO:0019079 + +[Term] +id: GO:0008168 +name: methyltransferase activity +namespace: molecular_function +alt_id: GO:0004480 +def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methylase" BROAD [] +xref: EC:2.1.1 +xref: Reactome:1062 +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups + +[Term] +id: GO:0008169 +name: C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008170 +name: N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008171 +name: O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008172 +name: S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008173 +name: RNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] +comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008174 +name: mRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008173 ! RNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008175 +name: tRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008173 ! RNA methyltransferase activity + +[Term] +id: GO:0008176 +name: tRNA (guanine-N7-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] +subset: gosubset_prok +synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33] +synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33] +synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] +synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] +xref: EC:2.1.1.33 +xref: MetaCyc:TRNA-(GUANINE-N7-)-METHYLTRANSFERASE-RXN +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0008177 +name: succinate dehydrogenase (ubiquinone) activity +namespace: molecular_function +alt_id: GO:0019737 +def: "Catalysis of the reaction: succinate + quinone = fumarate + quinol." [EC:1.3.5.1] +subset: gosubset_prok +synonym: "complex II" RELATED [EC:1.3.5.1] +synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] +synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] +synonym: "quinol:fumarate oxidoreductase activity" EXACT [] +synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] +synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] +synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] +xref: EC:1.3.5.1 +xref: Reactome:23070 +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor + +[Term] +id: GO:0008179 +name: adenylate cyclase binding +namespace: molecular_function +def: "Interacting selectively with the enzyme adenylate cyclase." [GOC:jl] +synonym: "adenylyl cyclase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0008180 +name: signalosome +namespace: cellular_component +def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] +synonym: "COP9 complex" NARROW [] +synonym: "CSN" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0008181 +name: tumor suppressor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way. +is_obsolete: true +consider: GO:0051726 + +[Term] +id: GO:0008184 +name: glycogen phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] +subset: gosubset_prok +xref: MetaCyc:GLYCOPHOSPHORYL-RXN +xref: Reactome:23099 +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0008186 +name: RNA-dependent ATPase activity +namespace: molecular_function +alt_id: GO:0004010 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] +is_a: GO:0042623 ! ATPase activity, coupled + +[Term] +id: GO:0008187 +name: poly-pyrimidine tract binding +namespace: molecular_function +def: "Interacting selectively with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0008188 +name: neuropeptide receptor activity +namespace: molecular_function +def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled +is_a: GO:0030594 ! neurotransmitter receptor activity +is_a: GO:0042923 ! neuropeptide binding + +[Term] +id: GO:0008189 +name: apoptosis inhibitor activity +namespace: molecular_function +def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb] +comment: This term was made obsolete because it represents involvement in a biological process. +is_obsolete: true +replaced_by: GO:0006916 + +[Term] +id: GO:0008190 +name: eukaryotic initiation factor 4E binding +namespace: molecular_function +def: "Interacting selectively with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "eIF4E binding" EXACT [] +is_a: GO:0031369 ! translation initiation factor binding + +[Term] +id: GO:0008191 +name: metalloendopeptidase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] +subset: gosubset_prok +synonym: "metalloprotease inhibitor" BROAD [] +synonym: "metalloproteinase inhibitor" BROAD [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0008192 +name: RNA guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] +xref: EC:2.7.7.- +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008193 +name: tRNA guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] +xref: EC:2.7.7.- +is_a: GO:0008192 ! RNA guanylyltransferase activity + +[Term] +id: GO:0008194 +name: UDP-glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] +subset: gosubset_prok +xref: Reactome:23123 +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0008195 +name: phosphatidate phosphatase activity +namespace: molecular_function +alt_id: GO:0004606 +def: "Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4] +synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4] +synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4] +synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4] +synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4] +synonym: "phosphatidate phosphohydrolase activity" EXACT [] +synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4] +xref: EC:3.1.3.4 +xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN +xref: Reactome:23125 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008196 +name: vitellogenin receptor activity +namespace: molecular_function +def: "Combining with vitellogenin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0008197 +name: yolk protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0005198 +consider: GO:0045735 + +[Term] +id: GO:0008198 +name: ferrous iron binding +namespace: molecular_function +def: "Interacting selectively with ferrous iron, Fe(II)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005506 ! iron ion binding + +[Term] +id: GO:0008199 +name: ferric iron binding +namespace: molecular_function +def: "Interacting selectively with ferric iron, Fe(III)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005506 ! iron ion binding + +[Term] +id: GO:0008200 +name: ion channel inhibitor activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016248 ! channel inhibitor activity + +[Term] +id: GO:0008201 +name: heparin binding +namespace: molecular_function +def: "Interacting selectively with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "heparan sulfate binding" RELATED [] +is_a: GO:0005539 ! glycosaminoglycan binding + +[Term] +id: GO:0008202 +name: steroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] +subset: gosubset_prok +synonym: "steroid metabolism" EXACT [] +xref: Reactome:192076 +xref: Reactome:211979 +xref: Reactome:221744 +xref: Reactome:230324 +xref: Reactome:238361 +xref: Reactome:244919 +xref: Reactome:249836 +xref: Reactome:252547 +xref: Reactome:255724 +xref: Reactome:259117 +xref: Reactome:262501 +xref: Reactome:265331 +xref: Reactome:268436 +xref: Reactome:274179 +xref: Reactome:280652 +xref: Reactome:286641 +xref: Reactome:289845 +xref: Reactome:290393 +xref: Reactome:291785 +xref: Reactome:293762 +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0008203 +name: cholesterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cholesterol metabolism" EXACT [] +is_a: GO:0016125 ! sterol metabolic process + +[Term] +id: GO:0008204 +name: ergosterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ergosterol metabolism" EXACT [] +is_a: GO:0016125 ! sterol metabolic process + +[Term] +id: GO:0008205 +name: ecdysone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ecdysone metabolism" EXACT [] +is_a: GO:0016125 ! sterol metabolic process + +[Term] +id: GO:0008206 +name: bile acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] +synonym: "bile acid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0008207 +name: C21-steroid hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] +synonym: "C21-steroid hormone metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0008208 +name: C21-steroid hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] +synonym: "C21-steroid hormone breakdown" EXACT [] +synonym: "C21-steroid hormone catabolism" EXACT [] +synonym: "C21-steroid hormone degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0008209 +name: androgen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "androgen metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0008210 +name: estrogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "estrogen metabolism" EXACT [] +synonym: "oestrogen metabolic process" EXACT [] +synonym: "oestrogen metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0008211 +name: glucocorticoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "glucocorticoid metabolism" EXACT [] +synonym: "glucocorticosteroid metabolic process" EXACT [] +synonym: "glucocorticosteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0008212 +name: mineralocorticoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "mineralocorticoid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0008213 +name: protein amino acid alkylation +namespace: biological_process +def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0008214 +name: protein amino acid dealkylation +namespace: biological_process +def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0008215 +name: spermine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "spermine metabolism" EXACT [] +xref: Reactome:141341 +xref: Reactome:211033 +xref: Reactome:220877 +xref: Reactome:229541 +xref: Reactome:273659 +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0008216 +name: spermidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +subset: gosubset_prok +synonym: "spermidine metabolism" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0008217 +name: regulation of blood pressure +namespace: biological_process +def: "The process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] +synonym: "blood pressure homeostasis" RELATED [] +synonym: "blood pressure regulation" EXACT [] +synonym: "control of blood pressure" RELATED [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0008218 +name: bioluminescence +namespace: biological_process +def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0008219 +name: cell death +namespace: biological_process +def: "The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:ems] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +synonym: "necrosis" RELATED [] +is_a: GO:0009987 ! cellular process +is_a: GO:0016265 ! death + +[Term] +id: GO:0008220 +name: necrosis +namespace: biological_process +def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma] +comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created. +is_obsolete: true +consider: GO:0001906 +consider: GO:0008219 +consider: GO:0012501 +consider: GO:0019835 + +[Term] +id: GO:0008222 +name: tumor antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true + +[Term] +id: GO:0008224 +name: Gram-positive antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +is_obsolete: true +consider: GO:0050830 + +[Term] +id: GO:0008225 +name: Gram-negative antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +is_obsolete: true +consider: GO:0050829 + +[Term] +id: GO:0008226 +name: tyramine receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/] +is_a: GO:0008227 ! amine receptor activity + +[Term] +id: GO:0008227 +name: amine receptor activity +namespace: molecular_function +def: "Combining with a biogenic amine to initiate a change in cell activity." [GOC:dph] +subset: gosubset_prok +synonym: "biogenic amine receptor" NARROW [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0008228 +name: opsonization +namespace: biological_process +def: "The process by which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002252 ! immune effector process +relationship: part_of GO:0006909 ! phagocytosis + +[Term] +id: GO:0008229 +name: opsonin activity +namespace: molecular_function +def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0003823 + +[Term] +id: GO:0008230 +name: ecdysone receptor holocomplex +namespace: cellular_component +def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] +is_a: GO:0005667 ! transcription factor complex +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0008231 +name: repressor ecdysone receptor complex +namespace: cellular_component +def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] +synonym: "repressor ecdysone receptor holocomplex" RELATED [] +is_a: GO:0008230 ! ecdysone receptor holocomplex + +[Term] +id: GO:0008232 +name: activator ecdysone receptor complex +namespace: cellular_component +def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] +synonym: "activator ecdysone receptor holocomplex" RELATED [] +is_a: GO:0008230 ! ecdysone receptor holocomplex + +[Term] +id: GO:0008233 +name: peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "hydrolase, acting on peptide bonds" EXACT [] +synonym: "peptide hydrolase activity" EXACT [] +synonym: "protease activity" EXACT [] +synonym: "proteinase activity" EXACT [] +xref: EC:3.4 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0008234 +name: cysteine-type peptidase activity +namespace: molecular_function +alt_id: GO:0004220 +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +subset: gosubset_prok +synonym: "cysteine protease activity" EXACT [] +synonym: "thiol protease activity" EXACT [] +xref: EC:3.4.-.- +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0008235 +name: metalloexopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE] +subset: gosubset_prok +is_a: GO:0008237 ! metallopeptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008236 +name: serine-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] +subset: gosubset_prok +synonym: "serine protease activity" EXACT [] +is_a: GO:0017171 ! serine hydrolase activity +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0008237 +name: metallopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +subset: gosubset_prok +synonym: "metalloprotease activity" EXACT [GOC:mah] +synonym: "metalloproteinase activity" EXACT [GOC:mah] +xref: Reactome:1795 +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0008238 +name: exopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE] +subset: gosubset_prok +synonym: "exoprotease activity" EXACT [] +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0008239 +name: dipeptidyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] +subset: gosubset_prok +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008240 +name: tripeptidyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] +xref: EC:3.4.14.- +is_a: GO:0008236 ! serine-type peptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008241 +name: peptidyl-dipeptidase activity +namespace: molecular_function +def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] +subset: gosubset_prok +xref: EC:3.4.15 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008242 +name: omega peptidase activity +namespace: molecular_function +def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] +subset: gosubset_prok +synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] +xref: EC:3.4.19 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008243 +name: plasminogen activator activity +namespace: molecular_function +alt_id: GO:0004296 +alt_id: GO:0004297 +def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "abbokinase activity" EXACT [EC:3.4.21.68] +synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-] +synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] +synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68] +synonym: "t-PA" RELATED [EC:3.4.21.68] +synonym: "t-plasminogen activator activity" NARROW [] +synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-] +synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-] +synonym: "tPA activity" NARROW [EC:3.4.21.-] +synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] +synonym: "u-PA" RELATED [EC:3.4.21.68] +synonym: "u-plasminogen activator activity" NARROW [] +synonym: "uPA" RELATED [EC:3.4.21.68] +synonym: "urinary esterase A" RELATED [EC:3.4.21.68] +synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] +synonym: "urokinase activity" RELATED [EC:3.4.21.-] +synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] +synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] +xref: EC:3.4.21.- +xref: EC:3.4.21.68 +xref: EC:3.4.21.73 +xref: MetaCyc:3.4.21.68-RXN +xref: MetaCyc:3.4.21.73-RXN +xref: Reactome:9757 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008245 +name: lysosomal membrane hydrogen-transporting ATPase +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "V-ATPase" RELATED [] +is_obsolete: true +consider: GO:0046611 + +[Term] +id: GO:0008246 +name: electron transfer flavoprotein +namespace: molecular_function +def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "ETF" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0008247 +name: 2-acetyl-1-alkylglycerophosphocholine esterase complex +namespace: cellular_component +def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206, UniProtKB:Q28017] +comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. +subset: gosubset_prok +synonym: "1-alkyl-2-acetylglycerophosphocholine esterase complex" EXACT [] +synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0008248 +name: pre-mRNA splicing factor activity +namespace: molecular_function +def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true +consider: GO:0008380 +consider: GO:0031202 + +[Term] +id: GO:0008250 +name: oligosaccharyltransferase complex +namespace: cellular_component +def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887] +synonym: "oligosaccharyl transferase complex" EXACT [] +synonym: "OST complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0008251 +name: tRNA-specific adenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] +subset: gosubset_prok +synonym: "tRNA-adenosine deaminase activity" EXACT [] +xref: EC:3.5.4.- +is_a: GO:0004000 ! adenosine deaminase activity + +[Term] +id: GO:0008252 +name: nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] +subset: gosubset_prok +synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31] +synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31] +synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31] +synonym: "NSP I" RELATED [EC:3.1.3.31] +synonym: "NSP II" RELATED [EC:3.1.3.31] +synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] +synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] +xref: EC:3.1.3.31 +xref: MetaCyc:NUCLEOTIDASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008253 +name: 5'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] +subset: gosubset_prok +synonym: "5' nucleotidase activity" EXACT [] +synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] +synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] +synonym: "5'-AMPase" NARROW [EC:3.1.3.5] +synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5] +synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5] +synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] +synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] +synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] +synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] +synonym: "AMPase" NARROW [EC:3.1.3.5] +synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] +synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] +synonym: "UMPase" NARROW [EC:3.1.3.5] +synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] +xref: EC:3.1.3.5 +xref: Reactome:23614 +is_a: GO:0008252 ! nucleotidase activity + +[Term] +id: GO:0008254 +name: 3'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] +synonym: "3' nucleotidase activity" EXACT [] +synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6] +synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6] +synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] +synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] +xref: EC:3.1.3.6 +xref: MetaCyc:3-NUCLEOTID-RXN +is_a: GO:0008252 ! nucleotidase activity + +[Term] +id: GO:0008255 +name: ecdysis-triggering hormone activity +namespace: molecular_function +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0008256 +name: protein histidine pros-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] +subset: gosubset_prok +synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1] +synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1] +synonym: "HK2" RELATED [EC:2.7.13.1] +synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] +xref: EC:2.7.13.1 +xref: MetaCyc:PROTEIN-HISTIDINE-PROS-KINASE-RXN +is_a: GO:0004673 ! protein histidine kinase activity + +[Term] +id: GO:0008257 +name: protein histidine tele-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] +synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2] +synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2] +synonym: "HK3" RELATED [EC:2.7.13.2] +synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] +xref: EC:2.7.13.2 +xref: MetaCyc:PROTEIN-HISTIDINE-TELE-KINASE-RXN +is_a: GO:0004673 ! protein histidine kinase activity + +[Term] +id: GO:0008258 +name: head involution +namespace: biological_process +def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0008259 +name: transforming growth factor beta ligand binding to type I receptor +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a function. +synonym: "TGF-beta ligand binding to type I receptor" EXACT [] +synonym: "TGFbeta ligand binding to type I receptor" EXACT [] +is_obsolete: true +consider: GO:0005025 +consider: GO:0005160 +consider: GO:0050431 + +[Term] +id: GO:0008260 +name: 3-oxoacid CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] +subset: gosubset_prok +synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5] +synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5] +synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5] +synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5] +synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5] +synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] +synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5] +synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5] +synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] +synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5] +synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5] +xref: EC:2.8.3.5 +xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN +xref: Reactome:23643 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008261 +name: allatostatin receptor activity +namespace: molecular_function +def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0008262 +name: importin-alpha export receptor activity +namespace: molecular_function +def: "Interacting selectively with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm." [GOC:mah, GOC:vw, PMID:12486120] +synonym: "importin-alpha binding" RELATED [] +is_a: GO:0005049 ! nuclear export signal receptor activity +is_a: GO:0008565 ! protein transporter activity + +[Term] +id: GO:0008263 +name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] +synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] +is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity + +[Term] +id: GO:0008265 +name: Mo-molybdopterin cofactor sulfurase activity +namespace: molecular_function +synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] +synonym: "molybdopterin cofactor sulfurase activity" EXACT [] +synonym: "molybdopterin synthase sulfurylase activity" EXACT [] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0008266 +name: poly(U) binding +namespace: molecular_function +def: "Interacting selectively with a sequence of uracil residues in an RNA molecule." [GOC:mah] +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0008267 +name: poly-glutamine tract binding +namespace: molecular_function +def: "Interacting selectively with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008268 +name: receptor signaling protein tyrosine kinase signaling protein activity +namespace: molecular_function +synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0008269 +name: JAK pathway signal transduction adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a molecule of the JAK signal transduction pathway and one or more other molecules of the pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +is_a: GO:0008268 ! receptor signaling protein tyrosine kinase signaling protein activity +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0008270 +name: zinc ion binding +namespace: molecular_function +def: "Interacting selectively with zinc (Zn) ions." [GOC:ai] +subset: gosubset_prok +synonym: "zinc binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0008271 +name: secondary active sulfate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +subset: gosubset_prok +synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] +synonym: "sulfate porter activity" RELATED [] +synonym: "sulphate porter activity" EXACT [] +is_a: GO:0015116 ! sulfate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0008272 +name: sulfate transport +namespace: biological_process +alt_id: GO:0006870 +def: "The directed movement of sulfate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +synonym: "sulphate transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0008273 +name: calcium, potassium:sodium antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] +synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] +is_a: GO:0015368 ! calcium:cation antiporter activity + +[Term] +id: GO:0008274 +name: gamma-tubulin ring complex +namespace: cellular_component +def: "A multiprotein complex composed of gamma-tubulin other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075] +synonym: "gammaTuRC" EXACT [] +is_a: GO:0000931 ! gamma-tubulin large complex + +[Term] +id: GO:0008275 +name: gamma-tubulin small complex +namespace: cellular_component +def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] +synonym: "gammaTuSC" EXACT [] +is_a: GO:0000930 ! gamma-tubulin complex + +[Term] +id: GO:0008276 +name: protein methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008277 +name: regulation of G-protein coupled receptor protein signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] +synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] +synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "regulation of GPCR protein signaling pathway" EXACT [] +synonym: "regulation of GPCR protein signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0008278 +name: cohesin complex +namespace: cellular_component +alt_id: GO:0008279 +def: "A protein complex required for sister chromatid cohesion in eukaryotes." [PMID:9887095] +subset: goslim_pir +synonym: "14S cohesin" NARROW [] +synonym: "SMC complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0008280 +name: cohesin core heterodimer +namespace: cellular_component +def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl] +synonym: "9S cohesin" NARROW [] +synonym: "Smc1-Smc3 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0008278 ! cohesin complex + +[Term] +id: GO:0008281 +name: sulfonylurea receptor activity +namespace: molecular_function +def: "Combining with sulfonylurea to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. +synonym: "sulphonylurea receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0008282 +name: ATP-sensitive potassium channel complex +namespace: cellular_component +def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity." [PMID:16308567, PMID:16956886] +is_a: GO:0034702 ! ion channel complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0008283 +name: cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0008284 +name: positive regulation of cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of cell proliferation" NARROW [] +synonym: "stimulation of cell proliferation" NARROW [] +synonym: "up regulation of cell proliferation" EXACT [] +synonym: "up-regulation of cell proliferation" EXACT [] +synonym: "upregulation of cell proliferation" EXACT [] +is_a: GO:0042127 ! regulation of cell proliferation +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0008283 ! cell proliferation + +[Term] +id: GO:0008285 +name: negative regulation of cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] +synonym: "down regulation of cell proliferation" EXACT [] +synonym: "down-regulation of cell proliferation" EXACT [] +synonym: "downregulation of cell proliferation" EXACT [] +synonym: "inhibition of cell proliferation" NARROW [] +is_a: GO:0042127 ! regulation of cell proliferation +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0008283 ! cell proliferation + +[Term] +id: GO:0008286 +name: insulin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] +synonym: "daf-2 receptor signaling pathway" NARROW [] +synonym: "insulin receptor signalling pathway" EXACT [] +xref: Reactome:211690 +xref: Reactome:221461 +xref: Reactome:230089 +xref: Reactome:238112 +xref: Reactome:244710 +xref: Reactome:249874 +xref: Reactome:252635 +xref: Reactome:255820 +xref: Reactome:259220 +xref: Reactome:262576 +xref: Reactome:265392 +xref: Reactome:268531 +xref: Reactome:274256 +xref: Reactome:280719 +xref: Reactome:282926 +xref: Reactome:286743 +xref: Reactome:288405 +xref: Reactome:74752 +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0008287 +name: protein serine/threonine phosphatase complex +namespace: cellular_component +def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0008288 +name: boss receptor activity +namespace: molecular_function +def: "Combining with the protein bride of sevenless (boss) to initiate a change in cell activity." [GOC:jl] +synonym: "sevenless receptor activity" RELATED [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0008289 +name: lipid binding +namespace: molecular_function +def: "Interacting selectively with a lipid." [GOC:ai] +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0008290 +name: F-actin capping protein complex +namespace: cellular_component +def: "A heterodimer consisting of alpha and a beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0008291 +name: acetylcholine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] +synonym: "acetylcholine metabolism" EXACT [] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0042439 ! ethanolamine and derivative metabolic process + +[Term] +id: GO:0008292 +name: acetylcholine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] +synonym: "acetylcholine anabolism" EXACT [] +synonym: "acetylcholine biosynthesis" EXACT [] +synonym: "acetylcholine formation" EXACT [] +synonym: "acetylcholine synthesis" EXACT [] +is_a: GO:0008291 ! acetylcholine metabolic process +is_a: GO:0042136 ! neurotransmitter biosynthetic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0008293 +name: torso signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the torso transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:go_curators] +synonym: "torso signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0008294 +name: calcium- and calmodulin-responsive adenylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] +synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] +synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] +xref: Reactome:23748 +is_a: GO:0004016 ! adenylate cyclase activity + +[Term] +id: GO:0008295 +name: spermidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "spermidine anabolism" EXACT [] +synonym: "spermidine biosynthesis" EXACT [] +synonym: "spermidine formation" EXACT [] +synonym: "spermidine synthesis" EXACT [] +xref: MetaCyc:BSUBPOLYAMSYN-PWY +xref: MetaCyc:POLYAMINSYN3-PWY +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0008216 ! spermidine metabolic process + +[Term] +id: GO:0008296 +name: 3'-5'-exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] +synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] +is_a: GO:0008408 ! 3'-5' exonuclease activity +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008297 +name: single-stranded DNA specific exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008298 +name: intracellular mRNA localization +namespace: biological_process +def: "Any process by which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of intracellular RNA localization" EXACT [] +synonym: "intracellular mRNA positioning" NARROW [] +synonym: "mRNA localization, intracellular" EXACT [] +synonym: "mRNA positioning, intracellular" NARROW [] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:0008299 +name: isoprenoid biosynthetic process +namespace: biological_process +alt_id: GO:0009241 +def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "isoprenoid anabolism" EXACT [] +synonym: "isoprenoid biosynthesis" EXACT [] +synonym: "isoprenoid formation" EXACT [] +synonym: "isoprenoid synthesis" EXACT [] +synonym: "polyisoprenoid anabolism" NARROW [] +synonym: "polyisoprenoid biosynthesis" NARROW [] +synonym: "polyisoprenoid biosynthetic process" NARROW [] +synonym: "polyisoprenoid formation" NARROW [] +synonym: "polyisoprenoid synthesis" NARROW [] +synonym: "polyterpene biosynthesis" NARROW [] +synonym: "polyterpene biosynthetic process" NARROW [] +xref: MetaCyc:POLYISOPRENSYN-PWY +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0008300 +name: isoprenoid catabolic process +namespace: biological_process +alt_id: GO:0016097 +def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "isoprenoid breakdown" EXACT [] +synonym: "isoprenoid catabolism" EXACT [] +synonym: "isoprenoid degradation" EXACT [] +synonym: "polyisoprenoid breakdown" NARROW [] +synonym: "polyisoprenoid catabolic process" NARROW [] +synonym: "polyisoprenoid catabolism" NARROW [] +synonym: "polyisoprenoid degradation" NARROW [] +synonym: "polyterpene catabolic process" NARROW [] +synonym: "polyterpene catabolism" NARROW [] +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0008301 +name: DNA bending activity +namespace: molecular_function +def: "The function of causing local conformational micropolymorphism of DNA in which the original B-DNA structure is only distorted but not extensively modified." [GOC:jl, PMID:10710711] +subset: gosubset_prok +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0008302 +name: ring canal formation, actin assembly +namespace: biological_process +def: "Recruitment and organization of actin filaments in female ring canals." [ISBN:0879694238] +is_a: GO:0007015 ! actin filament organization +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0007301 ! ovarian ring canal formation + +[Term] +id: GO:0008303 +name: caspase complex +namespace: cellular_component +def: "A cytosolic endopeptidase with specificity for the hydrolysis of aspartyl bonds. Caspases are involved in apoptosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0008304 +name: eukaryotic translation initiation factor 4 complex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "eIF-4" EXACT [] +is_obsolete: true +replaced_by: GO:0016281 + +[Term] +id: GO:0008305 +name: integrin complex +namespace: cellular_component +def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] +subset: gosubset_prok +synonym: "laminin receptor protein" RELATED [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0008306 +name: associative learning +namespace: biological_process +def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] +synonym: "classical conditioning" EXACT [] +synonym: "conditional learning" EXACT [] +synonym: "conditional response" EXACT [] +synonym: "Pavlovian conditioning" EXACT [] +is_a: GO:0007612 ! learning + +[Term] +id: GO:0008307 +name: structural constituent of muscle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0008308 +name: voltage-gated anion channel activity +namespace: molecular_function +alt_id: GO:0022844 +def: "Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion." [GOC:mtg_transport, ISBN:0815340729] +synonym: "voltage-dependent ion-selective channel activity" RELATED [] +synonym: "voltage-gated ion-selective channel activity" RELATED [] +is_a: GO:0005244 ! voltage-gated ion channel activity +is_a: GO:0005253 ! anion channel activity + +[Term] +id: GO:0008309 +name: double-stranded DNA specific exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008310 +name: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah] +is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity +is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity + +[Term] +id: GO:0008311 +name: double-stranded DNA specific 3'-5' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah] +is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity +is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity + +[Term] +id: GO:0008312 +name: 7S RNA binding +namespace: molecular_function +def: "Interacting selectively with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, UniProtKB:P37108] +subset: gosubset_prok +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0008313 +name: gurken receptor activity +namespace: molecular_function +def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] +is_a: GO:0005006 ! epidermal growth factor receptor activity + +[Term] +id: GO:0008314 +name: gurken receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf] +synonym: "gurken receptor signalling pathway" EXACT [] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0008315 +name: meiotic G2/MI transition +namespace: biological_process +def: "The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I." [PMID:15088480] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0008316 +name: structural constituent of vitelline membrane +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg." [GOC:mah, GOC:sensu] +synonym: "structural constituent of vitelline membrane (sensu Insecta)" NARROW [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0008317 +name: gurken receptor binding +namespace: molecular_function +def: "Interacting selectively with the gurken growth factor receptor." [GOC:ai] +synonym: "gurken receptor ligand" NARROW [] +is_a: GO:0005154 ! epidermal growth factor receptor binding + +[Term] +id: GO:0008318 +name: protein prenyltransferase activity +namespace: molecular_function +alt_id: GO:0008244 +def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] +xref: EC:2.5.1.- +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0008319 +name: prenyl protein specific endopeptidase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.24.- +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008320 +name: protein transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a protein from one side of a membrane to the other." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005515 ! protein binding +is_a: GO:0008565 ! protein transporter activity +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0008321 +name: Ral guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0008322 +name: Pro-X carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0030536 + +[Term] +id: GO:0008324 +name: cation transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:df, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "transmembrane cation transporter activity" EXACT [] +is_a: GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0008327 +name: methyl-CpG binding +namespace: molecular_function +def: "Interacting selectively with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] +is_a: GO:0000166 ! nucleotide binding +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0008328 +name: ionotropic glutamate receptor complex +namespace: cellular_component +def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0008329 +name: pattern recognition receptor activity +namespace: molecular_function +def: "Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens." [PMID:12507420, PMID:12925128, PMID:14523544] +comment: Note that this term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway; gene products which recognize polymeric structures such as polysaccharides or peptidoglycans in extracellular space, but are not directly coupled to signal transduction pathway, should use the term 'pattern binding ; GO:0001871' or its child terms. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'. +synonym: "macrophage receptor activity" RELATED [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0008330 +name: protein tyrosine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein threonine/tyrosine phosphate + H2O = protein threonine/tyrosine + phosphate." [GOC:mah] +xref: EC:3.1.3.- +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0008331 +name: high voltage-gated calcium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] +synonym: "high voltage gated calcium channel activity" EXACT [] +synonym: "high voltage-dependent calcium channel activity" EXACT [] +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0008332 +name: low voltage-gated calcium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] +synonym: "low voltage gated calcium channel activity" EXACT [] +synonym: "low voltage-dependent calcium channel activity" EXACT [] +synonym: "T-type channel" EXACT [] +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0008333 +name: endosome to lysosome transport +namespace: biological_process +def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0008334 +name: histone mRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:mah] +synonym: "histone mRNA metabolism" EXACT [] +xref: Reactome:111367 +xref: Reactome:111438 +xref: Reactome:206064 +xref: Reactome:210721 +xref: Reactome:210722 +xref: Reactome:211703 +xref: Reactome:211730 +xref: Reactome:215630 +xref: Reactome:220612 +xref: Reactome:220613 +xref: Reactome:221474 +xref: Reactome:221500 +xref: Reactome:224823 +xref: Reactome:230101 +xref: Reactome:241210 +xref: Reactome:244060 +xref: Reactome:244061 +xref: Reactome:244719 +xref: Reactome:244738 +xref: Reactome:246830 +xref: Reactome:249634 +xref: Reactome:284569 +xref: Reactome:286059 +xref: Reactome:286060 +xref: Reactome:286500 +xref: Reactome:286513 +xref: Reactome:77584 +xref: Reactome:77585 +xref: Reactome:77588 +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0008335 +name: ovarian ring canal stabilization +namespace: biological_process +def: "Maintenance of the structural integrity of the ring canals connecting the female germ-line cyst." [GOC:curators] +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0008336 +name: gamma-butyrobetaine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2." [EC:1.14.11.1] +subset: gosubset_prok +synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1] +synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] +synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] +synonym: "g-butyrobetaine dioxygenase activity" EXACT [] +synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1] +synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] +synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] +xref: EC:1.14.11.1 +xref: MetaCyc:1.14.11.1-RXN +xref: Reactome:24086 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0008337 +name: selectin +namespace: molecular_function +def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653] +comment: This term was made obsolete because it describes a class of gene products. +is_obsolete: true +consider: GO:0005102 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0030246 +consider: GO:0050839 + +[Term] +id: GO:0008338 +name: MAP kinase 1 activity +namespace: molecular_function +synonym: "ERK1" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004707 ! MAP kinase activity + +[Term] +id: GO:0008339 +name: MP kinase activity +namespace: molecular_function +synonym: "Mpk2" NARROW [] +synonym: "p38" NARROW [] +synonym: "SAPK2" NARROW [] +xref: EC:2.7.11.- +is_a: GO:0016909 ! SAP kinase activity + +[Term] +id: GO:0008340 +name: determination of adult life span +namespace: biological_process +def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0010259 ! multicellular organismal aging + +[Term] +id: GO:0008341 +name: response to cocaine (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jic] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +is_obsolete: true +consider: GO:0048148 + +[Term] +id: GO:0008342 +name: larval feeding behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jic, GOC:mah] +comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. +is_obsolete: true +replaced_by: GO:0030536 + +[Term] +id: GO:0008343 +name: adult feeding behavior +namespace: biological_process +def: "Feeding behavior in a fully developed and mature organism." [GOC:mah] +comment: See also the biological process term 'feeding behavior ; GO:0007631'. +synonym: "adult feeding behavior (sensu Insecta)" NARROW [] +synonym: "adult feeding behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0030534 ! adult behavior + +[Term] +id: GO:0008344 +name: adult locomotory behavior +namespace: biological_process +def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai] +comment: See also the biological process term 'locomotory behavior ; GO:0007626'. +synonym: "adult locomotory behaviour" EXACT [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0030534 ! adult behavior + +[Term] +id: GO:0008345 +name: larval locomotory behavior +namespace: biological_process +def: "Locomotory behavior in a larval (immature) organism." [GOC:ai] +comment: See also the biological process term 'locomotory behavior ; GO:0007626'. +synonym: "larval locomotory behaviour" EXACT [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0030537 ! larval behavior + +[Term] +id: GO:0008346 +name: larval walking behavior +namespace: biological_process +def: "The actions or reactions of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators] +synonym: "larval walking behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior + +[Term] +id: GO:0008347 +name: glial cell migration +namespace: biological_process +alt_id: GO:0043359 +def: "The orderly movement of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] +synonym: "glia cell migration" EXACT [] +synonym: "glial cell migration (sensu Nematoda and Protostomia)" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0008348 +name: negative regulation of antimicrobial humoral response +namespace: biological_process +alt_id: GO:0042154 +alt_id: GO:0042155 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] +synonym: "attenuation of antimicrobial humoral response" EXACT [] +synonym: "down regulation of antimicrobial humoral response" EXACT [] +synonym: "down-regulation of antimicrobial humoral response" EXACT [] +synonym: "downregulation of antimicrobial humoral response" EXACT [] +synonym: "inhibition of antimicrobial humoral response" NARROW [] +is_a: GO:0002759 ! regulation of antimicrobial humoral response +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0043901 ! negative regulation of multi-organism process +relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0008349 +name: MAP kinase kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] +synonym: "MAPKKKK" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity + +[Term] +id: GO:0008350 +name: kinetochore motor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes cellular component information. +is_obsolete: true +consider: GO:0000776 +consider: GO:0003777 + +[Term] +id: GO:0008351 +name: microtubule severing activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true +replaced_by: GO:0008017 +replaced_by: GO:0051013 + +[Term] +id: GO:0008352 +name: katanin complex +namespace: cellular_component +def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] +comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. +is_a: GO:0005875 ! microtubule associated complex +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0008353 +name: RNA polymerase subunit kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase) = ADP + phospho-(DNA-directed RNA polymerase)." [EC:2.7.11.23] +synonym: "[RNA-polymerase]-subunit kinase activity" EXACT [] +synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" EXACT [EC:2.7.11.23] +synonym: "CTD kinase activity" NARROW [EC:2.7.11.23] +synonym: "RNA-polymerase-subunit kinase activity" EXACT [EC:2.7.11.23] +synonym: "STK9" RELATED [EC:2.7.11.23] +xref: EC:2.7.11.23 +xref: MetaCyc:[RNA-POLYMERASE\]-SUBUNIT-KINASE-RXN +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0008354 +name: germ cell migration +namespace: biological_process +def: "The orderly movement of a germ cell, a cell specialized to produce haploid gametes, through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] +synonym: "germ-cell migration" EXACT [] +synonym: "primordial germ cell migration" RELATED [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0008355 +name: olfactory learning +namespace: biological_process +def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] +is_a: GO:0007612 ! learning +is_a: GO:0042048 ! olfactory behavior + +[Term] +id: GO:0008356 +name: asymmetric cell division +namespace: biological_process +def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] +synonym: "asymmetric cytokinesis" RELATED [] +synonym: "asymmetrical cell division" EXACT [] +synonym: "asymmetrical cytokinesis" RELATED [] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0008358 +name: maternal determination of anterior/posterior axis, embryo +namespace: biological_process +def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0008595 ! determination of anterior/posterior axis, embryo + +[Term] +id: GO:0008359 +name: regulation of bicoid mRNA localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0060281 ! regulation of oocyte development +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0045450 ! bicoid mRNA localization + +[Term] +id: GO:0008360 +name: regulation of cell shape +namespace: biological_process +alt_id: GO:0045788 +alt_id: GO:0045789 +def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0008361 +name: regulation of cell size +namespace: biological_process +def: "Any process that modulates the size of a cell." [GOC:go_curators] +subset: gosubset_prok +synonym: "cell size control" EXACT [] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0008362 +name: chitin-based embryonic cuticle biosynthetic process +namespace: biological_process +def: "Synthesis and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof layer is essential to provide structural integrity of the larval body." [GOC:bf, GOC:mtg_sensu, PMID:12019232] +synonym: "embryonic cuticle anabolism (sensu Insecta)" EXACT [] +synonym: "embryonic cuticle biosynthetic process (sensu Insecta)" EXACT [] +synonym: "embryonic cuticle formation (sensu Insecta)" EXACT [] +synonym: "embryonic cuticle synthesis (sensu Insecta)" EXACT [] +is_a: GO:0040003 ! chitin-based cuticle development + +[Term] +id: GO:0008363 +name: larval chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +synonym: "larval cuticle anabolism (sensu Insecta)" EXACT [] +synonym: "larval cuticle biosynthetic process (sensu Insecta)" EXACT [] +synonym: "larval cuticle formation (sensu Insecta)" EXACT [] +synonym: "larval cuticle synthesis (sensu Insecta)" EXACT [] +is_a: GO:0042337 ! chitin-based cuticle development during molting +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0008364 +name: pupal chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +synonym: "pupal cuticle anabolism (sensu Insecta)" EXACT [] +synonym: "pupal cuticle formation (sensu Insecta)" EXACT [] +synonym: "pupal cuticle synthesis (sensu Insecta)" EXACT [] +is_a: GO:0042337 ! chitin-based cuticle development during molting +relationship: part_of GO:0035209 ! pupal development + +[Term] +id: GO:0008365 +name: adult chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +synonym: "adult cuticle anabolism (sensu Insecta)" EXACT [] +synonym: "adult cuticle biosynthetic process (sensu Insecta)" EXACT [] +synonym: "adult cuticle formation (sensu Insecta)" EXACT [] +synonym: "adult cuticle synthesis (sensu Insecta)" EXACT [] +is_a: GO:0040003 ! chitin-based cuticle development + +[Term] +id: GO:0008366 +name: axon ensheathment +namespace: biological_process +alt_id: GO:0042553 +def: "Any process by which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] +synonym: "cellular axon ensheathment" EXACT [] +synonym: "cellular nerve ensheathment" RELATED [] +synonym: "nerve ensheathment" RELATED [] +is_a: GO:0007272 ! ensheathment of neurons + +[Term] +id: GO:0008367 +name: bacterial binding +namespace: molecular_function +def: "Interacting selectively with any part of a bacterial cell." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +synonym: "bacterium binding" EXACT [] +synonym: "binding to bacterium" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0008368 +name: Gram-negative bacterial binding +namespace: molecular_function +def: "Interacting selectively with any part of a Gram-negative bacterial cell." [GOC:jl] +subset: gosubset_prok +synonym: "binding to Gram-negative bacterium" EXACT [] +synonym: "Gram-negative bacterium binding" EXACT [] +is_a: GO:0008367 ! bacterial binding + +[Term] +id: GO:0008369 +name: obsolete molecular function +namespace: molecular_function +def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators] +comment: This term was made obsolete because it is unnecessary in the OBO flat file format. +is_obsolete: true + +[Term] +id: GO:0008370 +name: obsolete cellular component +namespace: cellular_component +def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators] +comment: This term was made obsolete because it is unnecessary in the OBO flat file format. +is_obsolete: true + +[Term] +id: GO:0008371 +name: obsolete biological process +namespace: biological_process +def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators] +comment: This term was made obsolete because it is unnecessary in the OBO flat file format. +is_obsolete: true + +[Term] +id: GO:0008373 +name: sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +xref: EC:2.4.99.- +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0008374 +name: O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +xref: Reactome:1150 +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0008375 +name: acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GlcNAc transferase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008376 +name: acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "GalNAc transferase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008377 +name: light-induced release of internally sequestered calcium ion +namespace: biological_process +def: "The process by which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] +synonym: "light-induced release of calcium from internal store" EXACT [] +synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT [] +synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT [] +is_a: GO:0051283 ! negative regulation of sequestering of calcium ion +relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction + +[Term] +id: GO:0008378 +name: galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.4.1.- +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008379 +name: thioredoxin peroxidase activity +namespace: molecular_function +alt_id: GO:0009031 +def: "Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] +subset: gosubset_prok +synonym: "thiol peroxidase activity" EXACT [] +synonym: "TPx activity" EXACT [] +synonym: "TrxPx activity" EXACT [] +xref: EC:1.11.1.- +xref: MetaCyc:RXN0-267 +is_a: GO:0051920 ! peroxiredoxin activity + +[Term] +id: GO:0008380 +name: RNA splicing +namespace: biological_process +alt_id: GO:0006395 +def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] +subset: gosubset_prok +synonym: "pre-mRNA splicing factor activity" RELATED [] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0008381 +name: mechanically-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022833 ! mechanically gated channel activity + +[Term] +id: GO:0008384 +name: IkappaB kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] +comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. The kinase is composed of alpha, beta and gamma subunits, of which the latter does not have kinase activity but is presumed to play a regulatory role. +synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10] +synonym: "CHUK" RELATED [EC:2.7.11.10] +synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10] +synonym: "IKBKA" RELATED [EC:2.7.11.10] +synonym: "IKBKB" RELATED [EC:2.7.11.10] +synonym: "IKK" RELATED [EC:2.7.11.10] +synonym: "IKK-1" RELATED [EC:2.7.11.10] +synonym: "IKK-2" RELATED [EC:2.7.11.10] +synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10] +synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10] +synonym: "STK12" RELATED [EC:2.7.11.10] +synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] +synonym: "TBK1" RELATED [EC:2.7.11.10] +xref: EC:2.7.11.10 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0008385 +name: IkappaB kinase complex +namespace: cellular_component +def: "A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role." [GOC:ma] +synonym: "IKK complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0008386 +name: cholesterol monooxygenase (side-chain-cleaving) activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] +synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] +synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6] +synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6] +synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6] +synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6] +synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6] +synonym: "Cyp11a1" NARROW [] +synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] +synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] +synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] +synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] +synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6] +synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] +synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] +synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] +xref: EC:1.14.15.6 +xref: MetaCyc:1.14.15.6-RXN +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008387 +name: steroid 7-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] +synonym: "cytochrome P450 CYP2A12" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008388 +name: testosterone 15-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] +synonym: "cytochrome P450 CYP2A4" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008389 +name: coumarin 7-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] +synonym: "cytochrome P450 CYP2A5" NARROW [] +xref: Reactome:24222 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008390 +name: testosterone 16-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O." [GOC:ai] +synonym: "cytochrome P450 CYP2B10" NARROW [] +synonym: "cytochrome P450 CYP2B9" NARROW [] +synonym: "cytochrome P450 CYP2D10" NARROW [] +synonym: "cytochrome P450 CYP2D11" NARROW [] +synonym: "cytochrome P450 CYP2D9" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008391 +name: arachidonic acid monooxygenase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2B19" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008392 +name: arachidonic acid epoxygenase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2J5" NARROW [] +synonym: "cytochrome P450 CYP2J6" NARROW [] +is_a: GO:0008391 ! arachidonic acid monooxygenase activity + +[Term] +id: GO:0008393 +name: fatty acid (omega-1)-hydroxylase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2E1" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008394 +name: olfactory-specific steroid hydroxylase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2G1" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008395 +name: steroid hydroxylase activity +namespace: molecular_function +def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0008396 +name: oxysterol 7-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] +synonym: "cytochrome P450 CYP7B1" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008397 +name: sterol 12-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] +synonym: "cytochrome P450 CYP8B1" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008398 +name: sterol 14-demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70] +subset: gosubset_prok +synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70] +synonym: "cytochrome P450 CYP51" NARROW [] +synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70] +synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70] +synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] +synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70] +synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70] +synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] +synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70] +xref: EC:1.14.13.70 +xref: MetaCyc:1.14.13.70-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0008399 +name: naphthalene hydroxylase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2F2" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008401 +name: retinoic acid 4-hydroxylase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP261" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008403 +name: 25-hydroxycholecalciferol-24-hydroxylase activity +namespace: molecular_function +alt_id: GO:0030344 +def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycalciferol." [ISBN:0471331309 "Biochemical Pathways"] +synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] +synonym: "cytochrome P450 CYP24" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008404 +name: arachidonic acid 14,15-epoxygenase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2C29" NARROW [] +synonym: "cytochrome P450 CYP2C39" NARROW [] +is_a: GO:0008391 ! arachidonic acid monooxygenase activity + +[Term] +id: GO:0008405 +name: arachidonic acid 11,12-epoxygenase activity +namespace: molecular_function +synonym: "cytochrome P450 CYP2C38" NARROW [] +is_a: GO:0008391 ! arachidonic acid monooxygenase activity + +[Term] +id: GO:0008406 +name: gonad development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048513 ! organ development +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0045137 ! development of primary sexual characteristics + +[Term] +id: GO:0008407 +name: bristle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the bristle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0022416 ! bristle development + +[Term] +id: GO:0008408 +name: 3'-5' exonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] +subset: gosubset_prok +synonym: "3'-5'-exonuclease activity" EXACT [] +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0008409 +name: 5'-3' exonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] +subset: gosubset_prok +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0008410 +name: CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] +subset: gosubset_prok +xref: EC:2.8.3.- +is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups + +[Term] +id: GO:0008411 +name: 4-hydroxybutyrate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] +subset: gosubset_prok +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008412 +name: 4-hydroxybenzoate octaprenyltransferase activity +namespace: molecular_function +alt_id: GO:0000043 +alt_id: GO:0048043 +alt_id: GO:0048044 +def: "Catalysis of the reaction: farnesylfarnesylgeranyl-PP + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN] +subset: gosubset_prok +synonym: "4-HB polyprenyltransferase activity" EXACT [] +synonym: "para-hydroxybenzoate transferase activity" EXACT [] +synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] +synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] +synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] +xref: EC:2.5.1.- +xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0008413 +name: 8-oxo-7,8-dihydroguanine triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanine triphosphate = 8-oxo-7,8-dihydroguanine phosphate + diphosphate." [PMID:7782328] +subset: gosubset_prok +synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] +synonym: "8-oxo-GTPase activity" EXACT [] +xref: EC:3.6.1.- +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0008414 +name: CDP-alcohol phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0008415 +name: acyltransferase activity +namespace: molecular_function +def: "Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier." [EC:2.3.1.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.3.1.- +xref: Reactome:1091 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0008416 +name: delta5-delta2,4-dienoyl-CoA isomerase activity +namespace: molecular_function +xref: EC:5.3.3.- +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0008417 +name: fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +subset: gosubset_prok +xref: EC:2.4.1.- +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008418 +name: protein N-terminal asparagine amidohydrolase activity +namespace: molecular_function +xref: EC:3.5.1.- +is_a: GO:0004067 ! asparaginase activity + +[Term] +id: GO:0008419 +name: RNA lariat debranching enzyme activity +namespace: molecular_function +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008420 +name: CTD phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0008421 +name: long-chain-fatty-acyl-glutamate deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] +synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55] +synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55] +synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] +xref: EC:3.5.1.55 +xref: MetaCyc:3.5.1.55-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008422 +name: beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] +subset: gosubset_prok +synonym: "amygdalase activity" NARROW [EC:3.2.1.21] +synonym: "amygdalinase" BROAD [EC:3.2.1.21] +synonym: "arbutinase activity" EXACT [EC:3.2.1.21] +synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21] +synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21] +synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21] +synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] +synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] +synonym: "cellobiase activity" NARROW [EC:3.2.1.21] +synonym: "elaterase activity" NARROW [EC:3.2.1.21] +synonym: "emulsin" RELATED [EC:3.2.1.21] +synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] +synonym: "gentobiase activity" NARROW [EC:3.2.1.21] +synonym: "limarase activity" NARROW [EC:3.2.1.21] +synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21] +synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] +synonym: "salicilinase activity" NARROW [EC:3.2.1.21] +xref: EC:3.2.1.21 +xref: MetaCyc:3.2.1.21-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0008423 +name: bleomycin hydrolase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] +xref: EC:3.4.22.40 +xref: MetaCyc:3.4.22.40-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0008424 +name: glycoprotein 6-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.68] +synonym: "FucT" RELATED [EC:2.4.1.68] +synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] +synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] +synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] +synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] +synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] +xref: EC:2.4.1.68 +xref: MetaCyc:2.4.1.68-RXN +is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity + +[Term] +id: GO:0008425 +name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] +subset: gosubset_prok +synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] +synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] +synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] +synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] +xref: EC:2.1.1.- +is_a: GO:0030580 ! quinone cofactor methyltransferase activity + +[Term] +id: GO:0008426 +name: protein kinase C inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] +synonym: "PKC inhibitor activity" EXACT [] +is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity + +[Term] +id: GO:0008427 +name: calcium-dependent protein kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity + +[Term] +id: GO:0008428 +name: ribonuclease inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] +subset: gosubset_prok +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0008429 +name: phosphatidylethanolamine binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0008430 +name: selenium binding +namespace: molecular_function +def: "Interacting selectively with selenium (Se)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0008431 +name: vitamin E binding +namespace: molecular_function +def: "Interacting selectively with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "alpha-tocopherol binding" NARROW [] +synonym: "tocopherol binding" EXACT [] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0008432 +name: JUN kinase binding +namespace: molecular_function +def: "Interacting selectively with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0008434 +name: vitamin D3 receptor activity +namespace: molecular_function +def: "Combining with vitamin D3, cholecalciferol, to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +synonym: "cholecaliferol receptor activity" EXACT [] +is_a: GO:0004879 ! ligand-dependent nuclear receptor activity + +[Term] +id: GO:0008435 +name: anticoagulant activity +namespace: molecular_function +def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0050819 + +[Term] +id: GO:0008436 +name: heterogeneous nuclear ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "hnRNP" EXACT [] +is_obsolete: true +replaced_by: GO:0030530 + +[Term] +id: GO:0008437 +name: thyrotropin-releasing hormone activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0008438 +name: 1-phosphatidylinositol-5-phosphate kinase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143] +comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref. +is_obsolete: true +consider: GO:0016309 + +[Term] +id: GO:0008439 +name: monophenol monooxygenase activator activity +namespace: molecular_function +def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "prophenol oxidase activator" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008440 +name: inositol trisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate." [EC:2.7.1.127] +synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] +synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127] +synonym: "inositol 1,4,5-trisphosphate 3-kinase activity" EXACT [] +synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] +synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127] +synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127] +synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] +synonym: "IP3K activity" NARROW [EC:2.7.1.127] +xref: EC:2.7.1.127 +xref: MetaCyc:2.7.1.127-RXN +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0008441 +name: 3'(2'),5'-bisphosphate nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] +subset: gosubset_prok +synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] +synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] +synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7] +synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] +synonym: "DPNPase activity" EXACT [EC:3.1.3.7] +synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7] +xref: EC:3.1.3.7 +xref: MetaCyc:3'(2')\,5'-BISPHOSPHATE-NUCLEOTIDASE-RXN +xref: Reactome:24620 +is_a: GO:0008252 ! nucleotidase activity + +[Term] +id: GO:0008442 +name: 3-hydroxyisobutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] +subset: gosubset_prok +xref: EC:1.1.1.31 +xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN +xref: Reactome:24621 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008443 +name: phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [GOC:jl] +subset: gosubset_prok +xref: EC:2.7.1.- +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008444 +name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate." [EC:2.7.8.5] +subset: gosubset_prok +synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5] +synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +synonym: "PGP synthase activity" EXACT [EC:2.7.8.5] +synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5] +synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5] +synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5] +synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5] +synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5] +synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] +xref: EC:2.7.8.5 +xref: MetaCyc:PHOSPHAGLYPSYN-RXN +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0008445 +name: D-aspartate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1] +synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1] +synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1] +synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1] +xref: EC:1.4.3.1 +xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN +is_a: GO:0015922 ! aspartate oxidase activity + +[Term] +id: GO:0008446 +name: GDP-mannose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O." [EC:4.2.1.47] +subset: gosubset_prok +synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] +synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47] +synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47] +synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47] +synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] +synonym: "Gmd" RELATED [EC:4.2.1.47] +synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47] +synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] +synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47] +xref: EC:4.2.1.47 +xref: MetaCyc:GDPMANDEHYDRA-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008447 +name: L-ascorbate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] +synonym: "AA oxidase activity" EXACT [EC:1.10.3.3] +synonym: "AAO" RELATED [EC:1.10.3.3] +synonym: "ascorbase activity" EXACT [EC:1.10.3.3] +synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3] +synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3] +synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] +synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3] +synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3] +synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3] +synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] +xref: EC:1.10.3.3 +xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0008448 +name: N-acetylglucosamine-6-phosphate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] +subset: gosubset_prok +synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] +synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25] +synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25] +synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] +xref: EC:3.5.1.25 +xref: MetaCyc:NAG6PDEACET-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0008449 +name: N-acetylglucosamine-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] +subset: gosubset_prok +synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] +synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] +synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14] +synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14] +synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] +synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] +synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14] +xref: EC:3.1.6.14 +xref: MetaCyc:3.1.6.14-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0008450 +name: O-sialoglycoprotein endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57] +synonym: "glycoprotease activity" RELATED [EC:3.4.24.57] +synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] +synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] +synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] +xref: EC:3.4.24.57 +xref: MetaCyc:3.4.24.57-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008451 +name: X-Pro aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9] +synonym: "aminopeptidase P" EXACT [] +synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] +synonym: "Xaa-Pro aminopeptidase activity" EXACT [] +xref: EC:3.4.11.9 +xref: MetaCyc:3.4.11.9-RXN +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0008452 +name: RNA ligase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:6.5.1.- +is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds + +[Term] +id: GO:0008453 +name: alanine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] +subset: gosubset_prok +synonym: "AGT activity" EXACT [EC:2.6.1.44] +synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] +synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] +synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44] +synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44] +synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] +xref: EC:2.6.1.44 +xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0008454 +name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] +synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145] +synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] +synonym: "GnTIV activity" EXACT [EC:2.4.1.145] +synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] +synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] +xref: EC:2.4.1.145 +xref: MetaCyc:2.4.1.145-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008455 +name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] +synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] +synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "GnTII activity" EXACT [EC:2.4.1.143] +synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] +synonym: "UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] +xref: EC:2.4.1.143 +xref: MetaCyc:2.4.1.143-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008456 +name: alpha-N-acetylgalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] +synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49] +synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] +synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49] +synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49] +synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] +synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] +xref: EC:3.2.1.49 +xref: MetaCyc:3.2.1.49-RXN +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0008457 +name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163] +synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] +xref: EC:2.4.1.163 +xref: MetaCyc:2.4.1.163-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008458 +name: carnitine O-octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine." [EC:2.3.1.137] +synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137] +synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] +synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137] +synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137] +synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] +xref: EC:2.3.1.137 +xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN +is_a: GO:0016406 ! carnitine O-acyltransferase activity +is_a: GO:0016414 ! O-octanoyltransferase activity + +[Term] +id: GO:0008459 +name: chondroitin 6-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] +synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17] +synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17] +synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17] +synonym: "chondroitin 6-sulphotransferase activity" EXACT [] +synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17] +xref: EC:2.8.2.17 +xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN +is_a: GO:0034481 ! chondroitin sulfotransferase activity + +[Term] +id: GO:0008460 +name: dTDP-glucose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.46] +subset: gosubset_prok +synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46] +synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] +synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46] +synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] +synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46] +synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46] +xref: EC:4.2.1.46 +xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008462 +name: endopeptidase Clp activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92] +synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92] +synonym: "Clp protease" NARROW [EC:3.4.21.92] +synonym: "ClpP" RELATED [EC:3.4.21.92] +synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] +synonym: "protease Ti activity" RELATED [EC:3.4.21.92] +xref: EC:3.4.21.92 +xref: MetaCyc:3.4.21.92-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008463 +name: formylmethionine deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-methionine + H2O = formate + L-methionine." [EC:3.5.1.31] +subset: gosubset_prok +synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31] +xref: EC:3.5.1.31 +xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008464 +name: gamma-glutamyl hydrolase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] +synonym: "conjugase activity" RELATED [EC:3.4.19.9] +synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] +synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9] +synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9] +synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] +synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9] +synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] +synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] +synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] +synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] +synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] +xref: EC:3.4.19.9 +xref: MetaCyc:3.4.19.9-RXN +is_obsolete: true +replaced_by: GO:0008242 + +[Term] +id: GO:0008465 +name: glycerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] +subset: gosubset_prok +synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] +xref: EC:1.1.1.29 +xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008466 +name: glycogenin glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] +synonym: "glycogenin activity" RELATED [EC:2.4.1.186] +synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] +synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186] +synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186] +xref: EC:2.4.1.186 +xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN +xref: Reactome:24685 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0008467 +name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate, with a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] +synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] +synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23] +synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] +synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED [] +synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] +synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] +xref: EC:2.8.2.23 +xref: MetaCyc:2.8.2.23-RXN +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0008469 +name: histone-arginine N-methyltransferase activity +namespace: molecular_function +alt_id: GO:0016276 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N-methyl-arginine." [EC:2.1.1.125] +synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125] +synonym: "histone protein methylase I" RELATED [EC:2.1.1.125] +synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125] +synonym: "protein methylase I activity" BROAD [EC:2.1.1.125] +synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125] +synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125] +xref: EC:2.1.1.125 +xref: MetaCyc:2.1.1.125-RXN +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity +is_a: GO:0042054 ! histone methyltransferase activity + +[Term] +id: GO:0008470 +name: isovaleryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10] +subset: gosubset_prok +synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10] +synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10] +synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] +synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] +xref: EC:1.3.99.10 +xref: MetaCyc:ISOVALERYL-COA-DEHYDROGENASE-RXN +xref: Reactome:24705 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0008471 +name: laccase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] +subset: gosubset_prok +synonym: "benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.2] +synonym: "p-diphenol oxidase activity" EXACT [EC:1.10.3.2] +synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] +synonym: "urushiol oxidase activity" EXACT [EC:1.10.3.2] +xref: EC:1.10.3.2 +xref: MetaCyc:LACCASE-RXN +xref: UM-BBD_enzymeID:e0629 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0008472 +name: metallocarboxypeptidase D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] +synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] +xref: EC:3.4.17.22 +xref: MetaCyc:3.4.17.22-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0008473 +name: ornithine cyclodeaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine = L-proline + NH3." [EC:4.3.1.12] +subset: gosubset_prok +synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12] +synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12] +synonym: "OCD activity" EXACT [EC:4.3.1.12] +synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12] +synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12] +xref: EC:4.3.1.12 +xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008474 +name: palmitoyl-(protein) hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] +synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] +synonym: "palmitoyl-protein hydrolase activity" EXACT [] +synonym: "palmitoyl-protein thioesterase activity" EXACT [] +synonym: "palmitoyl-protein thiolesterase activity" EXACT [] +xref: EC:3.1.2.22 +xref: MetaCyc:3.1.2.22-RXN +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0008475 +name: procollagen-lysine 5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] +synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] +synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] +synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] +synonym: "lysine-2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.4] +synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] +synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4] +synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" EXACT [EC:1.14.11.4] +synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.11.4] +synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4] +synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4] +synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4] +synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] +synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] +xref: EC:1.14.11.4 +xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0008476 +name: protein-tyrosine sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] +synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] +synonym: "protein-tyrosine sulphotransferase activity" EXACT [] +synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] +xref: EC:2.8.2.20 +xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0008477 +name: purine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] +subset: gosubset_prok +synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] +synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] +synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] +synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1] +synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1] +synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] +synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] +synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] +synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1] +synonym: "purine nucleosidase reaction" EXACT [] +synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1] +synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1] +synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1] +synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1] +synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] +xref: EC:3.2.2.1 +xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008478 +name: pyridoxal kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] +subset: gosubset_prok +synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] +synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] +synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] +synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] +synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] +synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] +synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] +synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] +xref: EC:2.7.1.35 +xref: MetaCyc:PYRIDOXKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008479 +name: queuine tRNA-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] +subset: gosubset_prok +synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29] +synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] +synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29] +synonym: "Q-insertase activity" EXACT [EC:2.4.2.29] +synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29] +synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29] +synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29] +synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29] +synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] +xref: EC:2.4.2.29 +xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0008480 +name: sarcosine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor." [EC:1.5.99.1] +subset: gosubset_prok +synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.99.1] +synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.99.1] +synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] +synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] +xref: EC:1.5.99.1 +xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0008481 +name: sphinganine kinase activity +namespace: molecular_function +alt_id: GO:0001728 +def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] +synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91] +synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] +synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91] +synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] +synonym: "sphingosine kinase activity" RELATED [] +xref: EC:2.7.1.91 +xref: MetaCyc:SPHINGANINE-KINASE-RXN +is_a: GO:0001727 ! lipid kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008482 +name: sulfite oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: SO3(2-) (sulfite) + O2 + H2O = SO4(2-) (sulfate) + H2O2." [EC:1.8.3.1] +subset: gosubset_prok +synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1] +synonym: "sulphite oxidase activity" EXACT [] +xref: EC:1.8.3.1 +xref: MetaCyc:PWY-5326 +xref: MetaCyc:SULFITE-OXIDASE-RXN +is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0008483 +name: transaminase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminotransferase activity" EXACT [] +xref: EC:2.6.1 +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0008484 +name: sulfuric ester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] +subset: gosubset_prok +synonym: "sulfatase activity" EXACT [] +synonym: "sulphuric ester hydrolase activity" EXACT [] +xref: EC:3.1.6 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0008486 +name: diphosphoinositol-polyphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] +synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52e] +synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] +synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52e] +synonym: "DIPP activity" EXACT [EC:3.6.1.52e] +xref: EC:3.6.1.52e +xref: MetaCyc:3.6.1.52-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008487 +name: prenyl-dependent CAAX protease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008488 +name: gamma-glutamyl carboxylase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:4.1.1.- +xref: Reactome:24735 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008489 +name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + glucosylceramide = lactosylceramide (galactosyl-beta-1,4-glucosylceramide) + UDP." [GOC:ai, PMID:9593693] +synonym: "LacCer synthase activity" EXACT [] +synonym: "lactosylceramide synthase activity" EXACT [] +synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0008490 +name: arsenite secondary active transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0008491 +def: "Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] +subset: gosubset_prok +synonym: "arsenite porter activity" RELATED [] +is_a: GO:0015105 ! arsenite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0008492 +name: cAMP generating peptide activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product. +synonym: "cyclic AMP generating peptide activity" EXACT [] +is_obsolete: true +consider: GO:0004016 +consider: GO:0005179 +consider: GO:0046058 + +[Term] +id: GO:0008493 +name: tetracycline transporter activity +namespace: molecular_function +def: "Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "tetracyclin transporter activity" EXACT [] +is_a: GO:0042895 ! antibiotic transporter activity + +[Term] +id: GO:0008494 +name: translation activator activity +namespace: molecular_function +def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] +is_a: GO:0008135 ! translation factor activity, nucleic acid binding + +[Term] +id: GO:0008495 +name: protoheme IX farnesyltransferase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "haem O synthase activity" EXACT [] +synonym: "heme O synthase activity" EXACT [] +synonym: "protohaem IX farnesyltransferase activity" EXACT [] +xref: EC:2.5.1.- +is_a: GO:0004311 ! farnesyltranstransferase activity + +[Term] +id: GO:0008496 +name: mannan endo-1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans." [EC:3.2.1.101] +synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] +synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] +synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] +synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101] +synonym: "endo-alpha-D-mannosidase activity" EXACT [] +synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] +synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101] +xref: EC:3.2.1.101 +xref: MetaCyc:3.2.1.101-RXN +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0008498 +name: phospholipid scrambling +namespace: molecular_function +def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +is_obsolete: true +replaced_by: GO:0017121 + +[Term] +id: GO:0008499 +name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] +synonym: "beta-1,3-GalTase activity" BROAD [] +synonym: "beta3Gal-Ts activity" BROAD [] +synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity + +[Term] +id: GO:0008500 +name: glycine-, glutamate-, thienylcyclohexylpiperidine binding +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a conglomeration of three terms. +is_obsolete: true +consider: GO:0016594 +consider: GO:0016595 +consider: GO:0016596 + +[Term] +id: GO:0008502 +name: melatonin receptor activity +namespace: molecular_function +def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0008503 +name: benzodiazepine receptor activity +namespace: molecular_function +def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. +is_a: GO:0030594 ! neurotransmitter receptor activity + +[Term] +id: GO:0008504 +name: monoamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015201 +def: "Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [ChEBI:25375, GOC:mah] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0008506 +name: sucrose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] +synonym: "hydrogen/sucrose transporter" RELATED [] +synonym: "sucrose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0008515 ! sucrose transmembrane transporter activity + +[Term] +id: GO:0008507 +name: sodium:iodide symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] +synonym: "sodium/iodide symporter" EXACT [] +is_a: GO:0015373 ! monovalent anion:sodium symporter activity + +[Term] +id: GO:0008508 +name: bile acid:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] +synonym: "sodium/bile acid symporter" EXACT [] +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0015125 ! bile acid transmembrane transporter activity + +[Term] +id: GO:0008509 +name: anion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "anion transporter activity" EXACT [] +xref: Reactome:3160 +is_a: GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0008510 +name: sodium:bicarbonate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] +synonym: "sodium/bicarbonate cotransporter" EXACT [] +synonym: "sodium:bicarbonate cotransporter activity" EXACT [] +is_a: GO:0015106 ! bicarbonate transmembrane transporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0008511 +name: sodium:potassium:chloride symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] +synonym: "sodium/potassium/chloride symporter" EXACT [] +is_a: GO:0015377 ! cation:chloride symporter activity + +[Term] +id: GO:0008512 +name: sulfate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] +synonym: "sulfate/hydrogen symporter" EXACT [] +synonym: "sulfate:proton symporter" EXACT [] +synonym: "sulphate:hydrogen symporter activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0008513 +name: secondary active organic cation transmembrane transporter activity +namespace: molecular_function +synonym: "organic cation porter activity" RELATED [] +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0008514 +name: organic anion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008509 ! anion transmembrane transporter activity + +[Term] +id: GO:0008515 +name: sucrose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019188 +def: "Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "sucrose permease (PTS) activity" EXACT [] +synonym: "sucrose permease activity" RELATED [] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0008516 +name: hexose uniporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015149 ! hexose transmembrane transporter activity +is_a: GO:0015292 ! uniporter activity + +[Term] +id: GO:0008517 +name: folic acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] +synonym: "folate transporter activity" EXACT [] +synonym: "vitamin B9 transporter activity" EXACT [] +synonym: "vitamin M transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0008518 +name: reduced folate carrier activity +namespace: molecular_function +def: "Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "reduced folate transporter" BROAD [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0008519 +name: ammonium transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0008520 +name: L-ascorbate:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1] +synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0008521 +name: acetyl-CoA transporter activity +namespace: molecular_function +def: "Enables the directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] +is_a: GO:0051185 ! coenzyme transporter activity + +[Term] +id: GO:0008523 +name: sodium-dependent multivitamin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0008524 +name: glucose 6-phosphate:phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-] +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0008525 +name: phosphatidylcholine transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of phosphatidylcholine into, out of, within or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005548 ! phospholipid transporter activity + +[Term] +id: GO:0008526 +name: phosphatidylinositol transporter activity +namespace: molecular_function +def: "Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "phosphatidylinositol transfer" EXACT [] +is_a: GO:0005548 ! phospholipid transporter activity + +[Term] +id: GO:0008527 +name: taste receptor activity +namespace: molecular_function +def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] +synonym: "gustatory receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0008528 +name: peptide receptor activity, G-protein coupled +namespace: molecular_function +def: "Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:dph, GOC:tb] +synonym: "G protein coupled peptide receptor activity" EXACT [] +synonym: "G-protein coupled peptide receptor activity" EXACT [] +synonym: "G-protein-coupled peptide receptor activity" EXACT [] +synonym: "peptide receptor activity, G protein coupled" EXACT [] +is_a: GO:0001653 ! peptide receptor activity +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0008529 +name: endogenous peptide receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0001653 +consider: GO:0005622 + +[Term] +id: GO:0008530 +name: exogenous peptide receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0001653 +consider: GO:0005576 + +[Term] +id: GO:0008531 +name: riboflavin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN." [EC:2.7.1.26] +subset: gosubset_prok +synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26] +synonym: "FK" RELATED [EC:2.7.1.26] +synonym: "flavokinase activity" EXACT [EC:2.7.1.26] +synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26] +synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26] +xref: EC:2.7.1.26 +xref: MetaCyc:RIBOFLAVINKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008532 +name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] +synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] +synonym: "GnTE activity" EXACT [EC:2.4.1.149] +synonym: "N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] +synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] +synonym: "UDP-GlcNAc:Galbeta1->4GlcNAcbeta-rbeta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] +synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] +xref: EC:2.4.1.149 +xref: MetaCyc:2.4.1.149-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008533 +name: astacin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] +synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] +synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] +xref: EC:3.4.24.21 +xref: MetaCyc:3.4.24.21-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008534 +name: oxidized purine base lesion DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0003907 +def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] +subset: gosubset_prok +synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] +synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] +synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] +synonym: "bifunctional DNA glycosylase activity" BROAD [] +synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] +synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] +synonym: "DNA glycosylase/AP-lyase activity" BROAD [] +synonym: "DNA glycosylase/beta-lyase activity" BROAD [] +synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] +synonym: "fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] +synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] +synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] +synonym: "Fpg protein" RELATED [EC:3.2.2.23] +synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] +xref: EC:3.2.2.23 +xref: MetaCyc:3.2.2.23-RXN +xref: Reactome:24932 +is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity +is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0008535 +name: respiratory chain complex IV assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm] +subset: gosubset_prok +synonym: "cytochrome c oxidase biogenesis" BROAD [] +synonym: "cytochrome c oxidase complex assembly" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0008536 +name: Ran GTPase binding +namespace: molecular_function +def: "Interacting selectively with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649] +synonym: "Ran protein binding" EXACT [] +synonym: "Ran-binding protein" RELATED [] +is_a: GO:0017016 ! Ras GTPase binding + +[Term] +id: GO:0008537 +name: proteasome activator complex +namespace: cellular_component +def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] +synonym: "PA28" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0022624 ! proteasome accessory complex + +[Term] +id: GO:0008538 +name: proteasome activator activity +namespace: molecular_function +def: "Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] +synonym: "PA28" NARROW [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0008539 +name: proteasome inhibitor activity +namespace: molecular_function +synonym: "PI-31" NARROW [] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0008540 +name: proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome, GOC:rb] +synonym: "proteasome regulatory particle, base subcomplex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0005838 ! proteasome regulatory particle + +[Term] +id: GO:0008541 +name: proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] +synonym: "proteasome regulatory particle, lid subcomplex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0005838 ! proteasome regulatory particle + +[Term] +id: GO:0008542 +name: visual learning +namespace: biological_process +def: "Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue." [GOC:jic, ISBN:0582227089] +synonym: "spatial learning" RELATED [] +is_a: GO:0007612 ! learning +is_a: GO:0007632 ! visual behavior + +[Term] +id: GO:0008543 +name: fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "FGF receptor signaling pathway" EXACT [] +synonym: "FGF receptor signalling pathway" EXACT [] +synonym: "FGFR signaling pathway" EXACT [] +synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] +xref: Reactome:190236 +xref: Reactome:190239 +xref: Reactome:190241 +xref: Reactome:190242 +xref: Reactome:190322 +xref: Reactome:190370 +xref: Reactome:190371 +xref: Reactome:190372 +xref: Reactome:190373 +xref: Reactome:190374 +xref: Reactome:190375 +xref: Reactome:190376 +xref: Reactome:190377 +xref: Reactome:211682 +xref: Reactome:211683 +xref: Reactome:211684 +xref: Reactome:211685 +xref: Reactome:211686 +xref: Reactome:211687 +xref: Reactome:211688 +xref: Reactome:211689 +xref: Reactome:212006 +xref: Reactome:212007 +xref: Reactome:212008 +xref: Reactome:212009 +xref: Reactome:212098 +xref: Reactome:221453 +xref: Reactome:221454 +xref: Reactome:221455 +xref: Reactome:221456 +xref: Reactome:221457 +xref: Reactome:221458 +xref: Reactome:221459 +xref: Reactome:221460 +xref: Reactome:221770 +xref: Reactome:221771 +xref: Reactome:221772 +xref: Reactome:221773 +xref: Reactome:221857 +xref: Reactome:230082 +xref: Reactome:230083 +xref: Reactome:230084 +xref: Reactome:230085 +xref: Reactome:230086 +xref: Reactome:230087 +xref: Reactome:230088 +xref: Reactome:230349 +xref: Reactome:230350 +xref: Reactome:230351 +xref: Reactome:230429 +xref: Reactome:230445 +xref: Reactome:238105 +xref: Reactome:238106 +xref: Reactome:238107 +xref: Reactome:238108 +xref: Reactome:238109 +xref: Reactome:238110 +xref: Reactome:238111 +xref: Reactome:238387 +xref: Reactome:238388 +xref: Reactome:238389 +xref: Reactome:238468 +xref: Reactome:238485 +xref: Reactome:249626 +xref: Reactome:249627 +xref: Reactome:249823 +xref: Reactome:249824 +xref: Reactome:249893 +xref: Reactome:249913 +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0008544 +name: epidermis development +namespace: biological_process +def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0007398 ! ectoderm development + +[Term] +id: GO:0008545 +name: JUN kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] +synonym: "JNKK" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004708 ! MAP kinase kinase activity + +[Term] +id: GO:0008546 +name: microtubule/chromatin interaction +namespace: biological_process +def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +consider: GO:0003677 +consider: GO:0003682 +consider: GO:0008017 +consider: GO:0030674 + +[Term] +id: GO:0008547 +name: protein-synthesizing GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +replaced_by: GO:0006412 +consider: GO:0008135 + +[Term] +id: GO:0008548 +name: signal-recognition-particle GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +replaced_by: GO:0005786 + +[Term] +id: GO:0008549 +name: dynamin GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "dynamine GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0006897 + +[Term] +id: GO:0008550 +name: tubulin GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +replaced_by: GO:0007021 + +[Term] +id: GO:0008551 +name: cadmium-exporting ATPase activity +namespace: molecular_function +alt_id: GO:0008561 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [EC:3.6.3.3] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3] +synonym: "cadmium exporting ATPase activity" EXACT [] +synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3] +synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3] +synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] +synonym: "cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] +xref: EC:3.6.3.3 +xref: MetaCyc:3.6.3.3-RXN +is_a: GO:0015086 ! cadmium ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0008552 +name: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2] +comment: This term was made obsolete because it represents more than one molecular function. +is_obsolete: true +consider: GO:0005385 +consider: GO:0015086 +consider: GO:0015087 +consider: GO:0015094 +consider: GO:0015099 +consider: GO:0015662 + +[Term] +id: GO:0008553 +name: hydrogen-exporting ATPase activity, phosphorylative mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism." [EC:3.6.3.6] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6] +synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6] +synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6] +synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6] +synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6] +synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] +synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] +synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6] +synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6] +synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6] +synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6] +synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6] +synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6] +xref: EC:3.6.3.6 +xref: MetaCyc:3.6.3.6-RXN +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0008554 +name: sodium-exporting ATPase activity, phosphorylative mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7] +synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] +synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7] +synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7] +synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7] +synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7] +synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT [] +synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7] +synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7] +synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7] +xref: EC:3.6.3.7 +xref: MetaCyc:3.6.3.7-RXN +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0008555 +name: chloride-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11] +synonym: "chloride ABC transporter" NARROW [] +synonym: "chloride transporting ATPase activity" EXACT [] +synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11] +synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11] +synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11] +synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11] +synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] +synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] +synonym: "cl--transporting ATPase activity" EXACT [EC:3.6.3.11] +xref: EC:3.6.3.11 +xref: MetaCyc:3.6.3.11-RXN +is_a: GO:0015108 ! chloride transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0008556 +name: potassium-transporting ATPase activity +namespace: molecular_function +alt_id: GO:0015618 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12] +synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12] +synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12] +synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12] +synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12] +synonym: "K+-transporting ATPase activity" EXACT [] +synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12] +synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12] +synonym: "potassium ABC transporter" NARROW [] +synonym: "potassium transporting ATPase activity" EXACT [] +synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12] +synonym: "potassium-uptake-ATPase activity" EXACT [] +xref: EC:3.6.3.12 +xref: MetaCyc:3.6.3.12-RXN +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0008558 +name: guanine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37] +synonym: "guanine ABC transporter" NARROW [] +xref: EC:3.6.3.37 +xref: MetaCyc:3.6.3.37-RXN +is_a: GO:0015208 ! guanine transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0008559 +name: xenobiotic-transporting ATPase activity +namespace: molecular_function +alt_id: GO:0005226 +alt_id: GO:0008560 +def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44] +synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44] +synonym: "MDR protein" RELATED [EC:3.6.3.44] +synonym: "multidrug resistance exporter" RELATED [] +synonym: "multidrug-resistance protein" RELATED [] +synonym: "P-glycoprotein" RELATED [] +synonym: "PDR protein" RELATED [EC:3.6.3.44] +synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44] +synonym: "steroid ABC transporter" NARROW [] +synonym: "steroid-transporting ATPase activity" EXACT [] +synonym: "xenobiotic ABC transporter" NARROW [] +xref: EC:3.6.3.44 +xref: MetaCyc:3.6.3.44-RXN +is_a: GO:0015239 ! multidrug transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0008563 +name: alpha-factor sex pheromone exporter +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48] +comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported. +synonym: "alpha-factor-transporting ATPase" RELATED [] +is_obsolete: true + +[Term] +id: GO:0008564 +name: protein-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the concomitant secretion of proteins." [EC:3.6.3.50] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50] +synonym: "protein-secreting ATPase activity" EXACT [] +xref: EC:3.6.3.50 +xref: MetaCyc:3.6.3.50-RXN +is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity + +[Term] +id: GO:0008565 +name: protein transporter activity +namespace: molecular_function +alt_id: GO:0015463 +def: "Enables the directed movement of proteins into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_goa +subset: gosubset_prok +synonym: "enzyme transporter activity" NARROW [] +synonym: "holin" RELATED [] +synonym: "protein carrier activity" EXACT [] +synonym: "secretin (sensu Bacteria)" RELATED [] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0008566 +name: mitochondrial protein-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51] +comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51] +xref: EC:3.6.3.51 +xref: MetaCyc:3.6.3.51-RXN +is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity + +[Term] +id: GO:0008567 +name: dynein ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +is_obsolete: true +consider: GO:0003777 +consider: GO:0007018 + +[Term] +id: GO:0008568 +name: microtubule-severing ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] +comment: See also the cellular component term 'katanin complex ; GO:0008352'. Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3] +synonym: "katanin activity" NARROW [EC:3.6.4.3] +xref: EC:3.6.4.3 +xref: MetaCyc:3.6.4.3-RXN +is_a: GO:0042623 ! ATPase activity, coupled + +[Term] +id: GO:0008569 +name: minus-end-directed microtubule motor activity +namespace: molecular_function +def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.5, GOC:mah] +synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5] +synonym: "minus-end-directed kinesin ATPase activity" BROAD [] +xref: EC:3.6.4.5 +xref: MetaCyc:3.6.4.5-RXN +is_a: GO:0003777 ! microtubule motor activity + +[Term] +id: GO:0008570 +name: myosin ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +is_obsolete: true +replaced_by: GO:0000146 +consider: GO:0030048 + +[Term] +id: GO:0008571 +name: non-chaperonin molecular chaperone ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0042623 +consider: GO:0006457 + +[Term] +id: GO:0008572 +name: nucleoplasmin ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +is_obsolete: true +replaced_by: GO:0042623 +consider: GO:0006333 + +[Term] +id: GO:0008573 +name: peroxisome-assembly ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7] +comment: This term was made obsolete because it incorporates process information. +is_obsolete: true +replaced_by: GO:0042623 +consider: GO:0007031 + +[Term] +id: GO:0008574 +name: plus-end-directed microtubule motor activity +namespace: molecular_function +def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.4] +synonym: "kinesin activity" RELATED [EC:3.6.4.4] +synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4] +synonym: "plus-end-directed kinesin ATPase activity" BROAD [] +xref: EC:3.6.4.4 +xref: MetaCyc:3.6.4.4-RXN +is_a: GO:0003777 ! microtubule motor activity + +[Term] +id: GO:0008575 +name: proteasome ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8] +comment: This term was made obsolete because it mentions a component term in the term text string. +is_obsolete: true +consider: GO:0016887 + +[Term] +id: GO:0008576 +name: vesicle-fusing ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6] +comment: This term was made obsolete because it incorporates process information. +is_obsolete: true +replaced_by: GO:0042623 +consider: GO:0006944 +consider: GO:0016192 + +[Term] +id: GO:0008579 +name: JUN kinase phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] +xref: EC:3.1.3.- +is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity + +[Term] +id: GO:0008580 +name: cytoskeletal regulator activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology. +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0008581 +name: ubiquitin-specific protease 5 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] +comment: This term was made obsolete because it represents a gene product. +synonym: "ubiquitin isopeptidase T activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004221 + +[Term] +id: GO:0008582 +name: regulation of synaptic growth at neuromuscular junction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0048742 ! regulation of skeletal muscle fiber development +is_a: GO:0051963 ! regulation of synaptogenesis +relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction + +[Term] +id: GO:0008583 +name: mystery cell fate differentiation +namespace: biological_process +def: "The process by which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium." [ISBN:0632030488, PMID:1295747] +synonym: "mystery cell fate differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0008584 +name: male gonad development +namespace: biological_process +def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0008406 ! gonad development +relationship: part_of GO:0046546 ! development of primary male sexual characteristics + +[Term] +id: GO:0008585 +name: female gonad development +namespace: biological_process +def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0008406 ! gonad development +relationship: part_of GO:0046545 ! development of primary female sexual characteristics + +[Term] +id: GO:0008586 +name: imaginal disc-derived wing vein morphogenesis +namespace: biological_process +def: "The process by which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_sensu] +synonym: "wing vein morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0008587 +name: imaginal disc-derived wing margin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. Morphogenesis pertains to the creation of form. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. +synonym: "wing margin morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0008588 +name: release of cytoplasmic sequestered NF-kappaB +namespace: biological_process +def: "The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus." [GOC:jl] +synonym: "activation of NF-kappa B" RELATED [] +synonym: "negative regulation of cytoplasmic NF-kappaB retention" RELATED [] +synonym: "negative regulation of cytoplasmic NF-kappaB sequestering" RELATED [] +synonym: "negative regulation of cytoplasmic NF-kappaB sequestration" RELATED [] +synonym: "negative regulation of cytoplasmic NF-kappaB storage" RELATED [] +synonym: "release of NF-kappaB sequestered in cytoplasm" EXACT [] +synonym: "release of NF-kappaB stored in cytoplasm" EXACT [] +is_a: GO:0042346 ! positive regulation of NF-kappaB import into nucleus +relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0008589 +name: regulation of smoothened signaling pathway +namespace: biological_process +alt_id: GO:0007226 +alt_id: GO:0043109 +def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] +synonym: "regulation of smoothened activity" RELATED [] +synonym: "regulation of smoothened by patched" RELATED [] +synonym: "regulation of smoothened receptor activity by patched" RELATED [] +synonym: "regulation of smoothened signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0008591 +name: regulation of Wnt receptor signaling pathway, calcium modulating pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "regulation of frizzled-2 signalling pathway" EXACT [] +is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway +relationship: regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway + +[Term] +id: GO:0008592 +name: regulation of Toll signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] +synonym: "regulation of Tl signaling pathway" EXACT [] +synonym: "regulation of Tl signalling pathway" EXACT [] +synonym: "regulation of Toll signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0008063 ! Toll signaling pathway + +[Term] +id: GO:0008593 +name: regulation of Notch signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] +synonym: "regulation of N signaling pathway" EXACT [] +synonym: "regulation of N signalling pathway" EXACT [] +synonym: "regulation of Notch signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0008594 +name: photoreceptor cell morphogenesis +namespace: biological_process +def: "Morphogenesis of photoreceptors, sensory cells that react to the presence of light." [GOC:jic] +synonym: "photoreceptor cell morphogenesis (sensu Endopterygota)" EXACT [] +synonym: "photoreceptor development (sensu Drosophila)" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0042461 ! photoreceptor cell development + +[Term] +id: GO:0008595 +name: determination of anterior/posterior axis, embryo +namespace: biological_process +def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0000578 ! embryonic axis specification +is_a: GO:0009948 ! anterior/posterior axis specification +relationship: part_of GO:0007351 ! tripartite regional subdivision + +[Term] +id: GO:0008597 +name: calcium-dependent protein serine/threonine phosphatase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] +synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] +xref: Reactome:25079 +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0008599 +name: protein phosphatase type 1 regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme protein phosphatase type 1." [GOC:ai] +synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0008601 +name: protein phosphatase type 2A regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai] +synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0008603 +name: cAMP-dependent protein kinase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] +subset: gosubset_prok +synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] +synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] +synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] +synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0008605 +name: protein kinase CK2 regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] +synonym: "casein kinase II, regulator" EXACT [] +synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0008607 +name: phosphorylase kinase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] +synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] +xref: EC:2.7.1.- +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0008608 +name: attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] +synonym: "amphotelic attachment" RELATED [] +synonym: "bipolar attachment" RELATED [] +synonym: "correction of merotelic attachment" NARROW [] +synonym: "kinetochore microtubule interaction" BROAD [] +synonym: "kinetochore-microtubule interaction" BROAD [] +synonym: "microtubule anchoring at kinetochore" EXACT [] +synonym: "microtubule and kinetochore interaction" RELATED [] +synonym: "microtubule capture" NARROW [] +synonym: "prevention of merotelic attachment" NARROW [] +synonym: "spindle kinetochore attachment" EXACT [] +is_a: GO:0034453 ! microtubule anchoring +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0008609 +name: alkylglycerone-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] +subset: gosubset_prok +synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26] +synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26] +synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] +synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26] +synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26] +synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26] +synonym: "DHAP-AT" RELATED [EC:2.5.1.26] +synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26] +xref: EC:2.5.1.26 +xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008610 +name: lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] +subset: gosubset_prok +synonym: "lipid anabolism" EXACT [] +synonym: "lipid biosynthesis" EXACT [] +synonym: "lipid formation" EXACT [] +synonym: "lipid synthesis" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0009058 ! biosynthetic process + +[Term] +id: GO:0008611 +name: ether lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] +subset: gosubset_prok +synonym: "ether lipid anabolism" EXACT [] +synonym: "ether lipid biosynthesis" EXACT [] +synonym: "ether lipid formation" EXACT [] +synonym: "ether lipid synthesis" EXACT [] +synonym: "plasmalogen biosynthetic process" NARROW [] +is_a: GO:0045017 ! glycerolipid biosynthetic process +is_a: GO:0046485 ! ether lipid metabolic process +is_a: GO:0046504 ! glycerol ether biosynthetic process + +[Term] +id: GO:0008612 +name: peptidyl-lysine modification to hypusine +namespace: biological_process +alt_id: GO:0046515 +def: "The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] +subset: gosubset_prok +synonym: "hypusine anabolism" EXACT [] +synonym: "hypusine anabolism from peptidyl-lysine" EXACT [] +synonym: "hypusine biosynthesis" EXACT [] +synonym: "hypusine biosynthetic process" EXACT [] +synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT [] +synonym: "hypusine formation" EXACT [] +synonym: "hypusine formation from peptidyl-lysine" EXACT [] +synonym: "hypusine synthesis" EXACT [] +synonym: "hypusine synthesis from peptidyl-lysine" EXACT [] +xref: RESID:AA0116 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0046516 ! hypusine metabolic process + +[Term] +id: GO:0008613 +name: diuretic hormone activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0008614 +name: pyridoxine metabolic process +namespace: biological_process +alt_id: GO:0006773 +def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "pyridoxine metabolism" EXACT [] +is_a: GO:0042816 ! vitamin B6 metabolic process + +[Term] +id: GO:0008615 +name: pyridoxine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] +subset: gosubset_prok +synonym: "pyridoxine anabolism" EXACT [] +synonym: "pyridoxine biosynthesis" EXACT [] +synonym: "pyridoxine formation" EXACT [] +synonym: "pyridoxine synthesis" EXACT [] +xref: MetaCyc:PYRIDOXSYN-PWY +is_a: GO:0008614 ! pyridoxine metabolic process +is_a: GO:0042819 ! vitamin B6 biosynthetic process + +[Term] +id: GO:0008616 +name: queuosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "queuosine anabolism" EXACT [] +synonym: "queuosine biosynthesis" EXACT [] +synonym: "queuosine formation" EXACT [] +synonym: "queuosine synthesis" EXACT [] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0046116 ! queuosine metabolic process +is_a: GO:0046118 ! 7-methylguanosine biosynthetic process + +[Term] +id: GO:0008617 +name: guanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "guanosine metabolism" EXACT [] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0008618 +name: 7-methylguanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "7-methylguanosine metabolism" EXACT [] +is_a: GO:0008617 ! guanosine metabolic process + +[Term] +id: GO:0008619 +name: RHEB small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0001558 +consider: GO:0051726 + +[Term] +id: GO:0008622 +name: epsilon DNA polymerase complex +namespace: cellular_component +def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000109 ! nucleotide-excision repair complex +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0008623 +name: chromatin accessibility complex +namespace: cellular_component +alt_id: GO:0016588 +def: "A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing." [GOC:bf, PMID:9252192] +synonym: "CHRAC" EXACT [] +synonym: "ISW2 complex" NARROW [] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0008624 +name: induction of apoptosis by extracellular signals +namespace: biological_process +def: "Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai] +xref: Reactome:109607 +xref: Reactome:208328 +xref: Reactome:211795 +xref: Reactome:212051 +xref: Reactome:212052 +xref: Reactome:217900 +xref: Reactome:221559 +xref: Reactome:221814 +xref: Reactome:221815 +xref: Reactome:226653 +xref: Reactome:230167 +xref: Reactome:230385 +xref: Reactome:230386 +xref: Reactome:73887 +xref: Reactome:75157 +xref: Reactome:75244 +is_a: GO:0006917 ! induction of apoptosis + +[Term] +id: GO:0008625 +name: induction of apoptosis via death domain receptors +namespace: biological_process +is_a: GO:0008624 ! induction of apoptosis by extracellular signals + +[Term] +id: GO:0008626 +name: induction of apoptosis by granzyme +namespace: biological_process +is_a: GO:0008624 ! induction of apoptosis by extracellular signals + +[Term] +id: GO:0008627 +name: induction of apoptosis by ionic changes +namespace: biological_process +is_a: GO:0008624 ! induction of apoptosis by extracellular signals + +[Term] +id: GO:0008628 +name: induction of apoptosis by hormones +namespace: biological_process +def: "Any process induced by hormones that directly activates any of the steps required for cell death by apoptosis." [GOC:bf] +is_a: GO:0008624 ! induction of apoptosis by extracellular signals +is_a: GO:0035081 ! induction of programmed cell death by hormones + +[Term] +id: GO:0008629 +name: induction of apoptosis by intracellular signals +namespace: biological_process +def: "Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai] +xref: Reactome:109606 +xref: Reactome:212064 +xref: Reactome:221827 +xref: Reactome:230395 +xref: Reactome:238434 +xref: Reactome:244996 +xref: Reactome:249878 +xref: Reactome:252597 +xref: Reactome:255783 +xref: Reactome:259177 +xref: Reactome:262533 +xref: Reactome:265360 +xref: Reactome:268489 +xref: Reactome:274214 +xref: Reactome:280683 +xref: Reactome:286703 +xref: Reactome:288367 +is_a: GO:0006917 ! induction of apoptosis + +[Term] +id: GO:0008630 +name: DNA damage response, signal transduction resulting in induction of apoptosis +namespace: biological_process +def: "A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death)." [GOC:go_curators] +is_a: GO:0008629 ! induction of apoptosis by intracellular signals +is_a: GO:0042770 ! DNA damage response, signal transduction + +[Term] +id: GO:0008631 +name: induction of apoptosis by oxidative stress +namespace: biological_process +def: "The activation, by oxidative stress, of any of the steps required for cell death by apoptosis." [GOC:ai] +is_a: GO:0008629 ! induction of apoptosis by intracellular signals + +[Term] +id: GO:0008632 +name: apoptotic program +namespace: biological_process +def: "The intracellular signaling cascade that results when a cell is triggered to undergo apoptosis." [GOC:go_curators] +is_a: GO:0007242 ! intracellular signaling cascade +relationship: part_of GO:0006915 ! apoptosis + +[Term] +id: GO:0008633 +name: activation of pro-apoptotic gene products +namespace: biological_process +def: "The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah] +synonym: "induction of pro-apoptotic gene products" RELATED [] +xref: Reactome:111446 +xref: Reactome:111447 +xref: Reactome:111448 +xref: Reactome:111452 +xref: Reactome:114294 +xref: Reactome:114452 +xref: Reactome:139893 +xref: Reactome:139895 +xref: Reactome:139898 +xref: Reactome:139910 +xref: Reactome:139915 +xref: Reactome:140534 +xref: Reactome:206265 +xref: Reactome:208870 +xref: Reactome:211127 +xref: Reactome:211606 +xref: Reactome:211718 +xref: Reactome:211799 +xref: Reactome:211872 +xref: Reactome:211873 +xref: Reactome:211889 +xref: Reactome:211890 +xref: Reactome:211932 +xref: Reactome:211933 +xref: Reactome:211970 +xref: Reactome:215841 +xref: Reactome:218522 +xref: Reactome:220975 +xref: Reactome:221380 +xref: Reactome:221488 +xref: Reactome:221563 +xref: Reactome:221637 +xref: Reactome:221638 +xref: Reactome:221653 +xref: Reactome:221654 +xref: Reactome:221697 +xref: Reactome:221735 +xref: Reactome:224996 +xref: Reactome:227398 +xref: Reactome:229645 +xref: Reactome:230112 +xref: Reactome:230169 +xref: Reactome:230230 +xref: Reactome:230244 +xref: Reactome:230245 +xref: Reactome:230407 +xref: Reactome:238036 +xref: Reactome:238269 +xref: Reactome:238354 +xref: Reactome:75108 +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: part_of GO:0008632 ! apoptotic program + +[Term] +id: GO:0008634 +name: negative regulation of survival gene product expression +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of survival gene product activity" EXACT [] +synonym: "down-regulation of survival gene product activity" EXACT [] +synonym: "downregulation of survival gene product activity" EXACT [] +synonym: "inhibition of survival gene product activity" NARROW [] +synonym: "negative regulation of survival gene product activity" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of survival gene products" EXACT [] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0045884 ! regulation of survival gene product expression + +[Term] +id: GO:0008635 +name: caspase activation via cytochrome c +namespace: biological_process +def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] +xref: Reactome:111459 +xref: Reactome:211727 +xref: Reactome:221496 +xref: Reactome:230117 +xref: Reactome:238141 +is_a: GO:0006919 ! caspase activation + +[Term] +id: GO:0008636 +name: caspase activation via phosphorylation +namespace: biological_process +def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0006919 ! caspase activation + +[Term] +id: GO:0008637 +name: apoptotic mitochondrial changes +namespace: biological_process +def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah] +is_a: GO:0007005 ! mitochondrion organization +relationship: part_of GO:0008632 ! apoptotic program + +[Term] +id: GO:0008638 +name: protein tagging activity +namespace: molecular_function +def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl] +comment: This term was made obsolete because it represents a biological process and a molecular function. +is_obsolete: true +consider: GO:0005515 +consider: GO:0006464 +consider: GO:0031386 + +[Term] +id: GO:0008641 +name: small protein activating enzyme activity +namespace: molecular_function +alt_id: GO:0008642 +def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "ubiquitin-like activating enzyme activity" NARROW [] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0008643 +name: carbohydrate transport +namespace: biological_process +alt_id: GO:0006861 +alt_id: GO:0008644 +def: "The directed movement of carbohydrate into, out of, within or between cells. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "sugar transport" NARROW [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0008645 +name: hexose transport +namespace: biological_process +def: "The directed movement of hexose into, out of, within or between cells. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:ai] +subset: gosubset_prok +xref: Reactome:189200 +is_a: GO:0015749 ! monosaccharide transport + +[Term] +id: GO:0008646 +name: high-affinity hexose transport +namespace: biological_process +def: "The directed, high-affinity movement of a hexose into, out of, within or between cells. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +is_a: GO:0008645 ! hexose transport +is_a: GO:0034219 ! transmembrane carbohydrate transport + +[Term] +id: GO:0008647 +name: low-affinity hexose transport +namespace: biological_process +def: "The directed, low-affinity movement of a hexose into, out of, within or between cells. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] +is_a: GO:0008645 ! hexose transport +is_a: GO:0034219 ! transmembrane carbohydrate transport + +[Term] +id: GO:0008648 +name: tachykinin +namespace: molecular_function +def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005102 +consider: GO:0045909 +consider: GO:0045987 +consider: GO:0046878 + +[Term] +id: GO:0008649 +name: rRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008173 ! RNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008650 +name: rRNA (uridine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity + +[Term] +id: GO:0008651 +name: actin polymerizing activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0030041 +replaced_by: GO:0042802 + +[Term] +id: GO:0008652 +name: amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "amino acid anabolism" EXACT [] +synonym: "amino acid biosynthesis" EXACT [] +synonym: "amino acid formation" EXACT [] +synonym: "amino acid synthesis" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process +is_a: GO:0009309 ! amine biosynthetic process + +[Term] +id: GO:0008653 +name: lipopolysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipopolysaccharide metabolism" EXACT [] +synonym: "LPS metabolic process" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0008654 +name: phospholipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phospholipid anabolism" EXACT [] +synonym: "phospholipid biosynthesis" EXACT [] +synonym: "phospholipid formation" EXACT [] +synonym: "phospholipid synthesis" EXACT [] +xref: MetaCyc:LIPASYN-PWY +xref: MetaCyc:PHOSLIPSYN-PWY +xref: MetaCyc:PHOSLIPSYN2-PWY +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0046467 ! membrane lipid biosynthetic process + +[Term] +id: GO:0008655 +name: pyrimidine salvage +namespace: biological_process +def: "Any process that generates a pyrimidine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006206 ! pyrimidine base metabolic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0008656 +name: caspase activator activity +namespace: molecular_function +def: "Increases the rate of proteolysis catalyzed by a caspase." [GOC:mah] +is_a: GO:0016505 ! apoptotic protease activator activity +is_a: GO:0043028 ! caspase regulator activity + +[Term] +id: GO:0008657 +name: DNA gyrase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of DNA gyrase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0008658 +name: penicillin binding +namespace: molecular_function +def: "Interacting selectively with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0008659 +name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.-, GOC:ai] +synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] +xref: EC:4.2.1.- +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008660 +name: 1-aminocyclopropane-1-carboxylate deaminase activity +namespace: molecular_function +alt_id: GO:0018806 +def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3." [EC:3.5.99.7] +comment: Note that this function was formerly EC:4.1.99.4. +subset: gosubset_prok +synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7] +synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7] +synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7] +synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7] +xref: EC:3.5.99.7 +xref: MetaCyc:4.1.99.4-RXN +xref: UM-BBD_enzymeID:e0274 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008661 +name: 1-deoxy-D-xylulose-5-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2." [EC:2.2.1.7] +subset: gosubset_prok +synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] +synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] +synonym: "DOXP synthase activity" EXACT [] +synonym: "DXP-synthase activity" EXACT [] +synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7] +xref: EC:2.2.1.7 +xref: MetaCyc:DXS-RXN +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0008662 +name: 1-phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] +subset: gosubset_prok +synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56] +synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56] +synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] +synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56] +synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] +synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] +xref: EC:2.7.1.56 +xref: MetaCyc:1PFRUCTPHOSN-RXN +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0008663 +name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] +subset: gosubset_prok +synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16] +synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16] +synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] +synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16] +synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] +synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] +synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16] +synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16] +synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] +synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] +synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16] +synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] +xref: EC:3.1.4.16 +xref: MetaCyc:CYCPHOSDIESTER-RXN +is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0008664 +name: 2'-5'-RNA ligase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "2'-5' RNA ligase activity" EXACT [] +xref: EC:6.5.1.- +is_a: GO:0008452 ! RNA ligase activity + +[Term] +id: GO:0008665 +name: 2'-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group from one compound to the 2' position of another." [GOC:jl, GOC:mah] +subset: gosubset_prok +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0008666 +name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate." [EC:2.3.1.117] +subset: gosubset_prok +synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] +synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] +synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] +synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] +synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117] +synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117] +synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117] +xref: EC:2.3.1.117 +xref: MetaCyc:TETHYDPICSUCC-RXN +is_a: GO:0016749 ! N-succinyltransferase activity + +[Term] +id: GO:0008667 +name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+." [EC:1.3.1.28] +subset: gosubset_prok +synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28] +synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28] +xref: EC:1.3.1.28 +xref: MetaCyc:DHBDEHYD-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008668 +name: (2,3-dihydroxybenzoyl)adenylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate." [EC:2.7.7.58, MetaCyc:2.7.7.58-RXN] +subset: gosubset_prok +synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] +synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58] +xref: EC:2.7.7.58 +xref: MetaCyc:DHBAMPLIG-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008669 +name: 2,3-dihydroxy-phenylpropionate 1,2-dioxygenase activity +namespace: molecular_function +xref: EC:1.13.11.- +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0008670 +name: 2,4-dienoyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] +subset: gosubset_prok +synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34] +synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34] +synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34] +synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] +synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] +xref: EC:1.3.1.34 +xref: MetaCyc:DIENOYLCOAREDUCT-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008671 +name: 2-dehydro-3-deoxygalactonokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate." [EC:2.7.1.58] +subset: gosubset_prok +synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58] +synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58] +synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58] +synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58] +synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58] +xref: EC:2.7.1.58 +xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008672 +name: 2-dehydro-3-deoxyglucarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] +subset: gosubset_prok +synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20] +synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20] +synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20] +synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20] +xref: EC:4.1.2.20 +xref: MetaCyc:KDGALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008673 +name: 2-dehydro-3-deoxygluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.45] +subset: gosubset_prok +synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45] +synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45] +synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45] +synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45] +synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45] +synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45] +synonym: "KDG kinase activity" EXACT [EC:2.7.1.45] +synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45] +xref: EC:2.7.1.45 +xref: MetaCyc:DEOXYGLUCONOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008674 +name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.21] +subset: gosubset_prok +synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21] +synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21] +synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21] +synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] +synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21] +synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21] +synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21] +synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] +synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] +synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] +synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21] +xref: EC:4.1.2.21 +xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008675 +name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] +subset: gosubset_prok +synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14] +synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14] +synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] +synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14] +synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14] +synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14] +synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] +synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] +synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14] +synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14] +synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14] +synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] +synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] +synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14] +xref: EC:4.1.2.14 +xref: MetaCyc:KDPGALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008676 +name: 3-deoxy-8-phosphooctulonate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate." [EC:2.5.1.55] +comment: Note that this function was formerly EC:4.1.2.16. +subset: gosubset_prok +synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55] +synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55] +synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] +synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55] +synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55] +synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] +synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] +synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] +synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55] +synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] +synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55] +synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55] +synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55] +xref: EC:2.5.1.55 +xref: MetaCyc:KDO-8PSYNTH-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008677 +name: 2-dehydropantoate 2-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+." [EC:1.1.1.169] +subset: gosubset_prok +synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169] +synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169] +synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] +synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169] +synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169] +synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] +synonym: "KPA reductase activity" EXACT [EC:1.1.1.169] +xref: EC:1.1.1.169 +xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008678 +name: 2-deoxy-D-gluconate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] +subset: gosubset_prok +synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125] +synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125] +synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125] +xref: EC:1.1.1.125 +xref: MetaCyc:KDUD-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008679 +name: 2-hydroxy-3-oxopropionate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] +subset: gosubset_prok +synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60] +synonym: "tartronate semialdehyde reductase activity" EXACT [EC:1.1.1.60] +xref: EC:1.1.1.60 +xref: MetaCyc:TSA-REDUCT-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008681 +name: 2-octaprenyl-6-methoxyphenol hydroxylase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008682 +name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] +xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0008683 +name: 2-oxoglutarate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate = succinate semialdehyde + CO2." [EC:4.1.1.71] +subset: gosubset_prok +synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71] +synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71] +synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] +synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71] +synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] +xref: EC:4.1.1.71 +xref: MetaCyc:2-OXOGLUT-DECARBOX-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008684 +name: 2-oxopent-4-enoate hydratase activity +namespace: molecular_function +alt_id: GO:0018821 +def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] +subset: gosubset_prok +synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80] +synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80] +synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80] +synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80] +synonym: "OEH activity" EXACT [EC:4.2.1.80] +xref: EC:4.2.1.80 +xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN +xref: UM-BBD_enzymeID:e0078 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008685 +name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP." [EC:4.6.1.12, GOC:mlg] +subset: gosubset_prok +synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12] +synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12] +synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12] +synonym: "MECP synthase activity" EXACT [] +xref: EC:4.6.1.12 +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0008686 +name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate." [MetaCyc:DIOHBUTANONEPSYN-RXN] +subset: gosubset_prok +xref: EC:4.1.99.12 +xref: MetaCyc:DIOHBUTANONEPSYN-RXN +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0008687 +name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde." [EC:1.13.11.15] +subset: gosubset_prok +synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15] +synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] +synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] +synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15] +xref: EC:1.13.11.15 +xref: MetaCyc:1.13.11.15-RXN +xref: UM-BBD_enzymeID:e0125 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0008688 +name: 3-(3-hydroxy-phenyl)propionate hydroxylase activity +namespace: molecular_function +xref: EC:1.14.13.- +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008689 +name: 3-demethylubiquinone-9 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [EC:2.1.1.64] +subset: gosubset_prok +synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64] +synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64] +synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64] +synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64] +xref: EC:2.1.1.64 +xref: MetaCyc:DHHB-METHYLTRANSFER-RXN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008690 +name: 3-deoxy-manno-octulosonate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] +subset: gosubset_prok +synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] +synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] +synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38] +synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38] +synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] +synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38] +synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38] +synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] +synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] +synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] +synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] +xref: EC:2.7.7.38 +xref: MetaCyc:CPM-KDOSYNTH-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008691 +name: 3-hydroxybutyryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] +subset: gosubset_prok +synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157] +synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157] +synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] +synonym: "BHBD activity" EXACT [EC:1.1.1.157] +synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157] +synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] +synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] +xref: EC:1.1.1.157 +xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008692 +name: 3-hydroxybutyryl-CoA epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] +subset: gosubset_prok +synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3] +synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3] +synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3] +xref: EC:5.1.2.3 +xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0008693 +name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60] +subset: gosubset_prok +synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60] +synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] +synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60] +synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] +synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] +synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60] +synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] +synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60] +synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60] +synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60] +synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60] +synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] +synonym: "FabA" RELATED [EC:4.2.1.60] +synonym: "HDDase activity" EXACT [EC:4.2.1.60] +xref: EC:4.2.1.60 +xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0008694 +name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity +namespace: molecular_function +alt_id: GO:0019167 +def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] +subset: gosubset_prok +synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] +synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] +synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] +synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] +synonym: "PPHB decarboxylase activity" EXACT [] +synonym: "UbiD" RELATED [] +synonym: "UbiX" RELATED [] +xref: EC:4.1.1.- +xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008695 +name: 3-phenylpropionate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] +synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19] +synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19] +synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19] +synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] +xref: EC:1.14.12.19 +xref: UM-BBD_enzymeID:e0307 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0008696 +name: 4-amino-4-deoxychorismate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate." [MetaCyc:ADCLY-RXN] +comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. +subset: gosubset_prok +synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38] +synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38] +synonym: "ADC lyase activity" EXACT [EC:4.1.3.38] +synonym: "aminodeoxychorismate lyase activity" EXACT [] +synonym: "enzyme X activity" RELATED [EC:4.1.3.38] +synonym: "p-aminobenzoate synthetase" RELATED [] +synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] +synonym: "para-aminobenzoic acid synthase" RELATED [] +xref: EC:4.1.3.38 +xref: MetaCyc:ADCLY-RXN +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0008697 +name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17] +subset: gosubset_prok +synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17] +synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17] +synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17] +xref: EC:5.3.1.17 +xref: MetaCyc:5.3.1.17-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008700 +name: 4-hydroxy-2-oxoglutarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] +subset: gosubset_prok +synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16] +synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] +synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] +synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] +synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] +synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] +synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16] +synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16] +synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16] +synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] +synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16] +synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16] +synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16] +xref: EC:4.1.3.16 +xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008701 +name: 4-hydroxy-2-oxovalerate aldolase activity +namespace: molecular_function +alt_id: GO:0018804 +def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = pyruvate + acetaldehyde." [EC:4.1.3.39] +synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39] +synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39] +synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39] +synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39] +synonym: "DmpG" RELATED [EC:4.1.3.39] +synonym: "HOA" RELATED [EC:4.1.3.39] +xref: EC:4.1.3.39 +xref: UM-BBD_enzymeID:e0077 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008703 +name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+." [EC:1.1.1.193] +subset: gosubset_prok +synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] +synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193] +synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193] +xref: EC:1.1.1.193 +xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008704 +name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity +namespace: molecular_function +alt_id: GO:0018843 +def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] +subset: gosubset_prok +synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] +synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] +synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10] +synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10] +synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10] +synonym: "HHDD isomerase activity" EXACT [] +synonym: "hpaG-1" RELATED [] +synonym: "hpaG1" RELATED [] +xref: EC:5.3.3.10 +xref: MetaCyc:5.3.3.10-RXN +xref: UM-BBD_enzymeID:e0135 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0008705 +name: methionine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine." [EC:2.1.1.13] +subset: gosubset_prok +synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13] +synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] +synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13] +synonym: "MetH" RELATED [EC:2.1.1.13] +synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13] +synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] +synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] +synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13] +synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] +xref: EC:2.1.1.13 +xref: MetaCyc:HOMOCYSMETB12-RXN +xref: Reactome:25894 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0008706 +name: 6-phospho-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] +subset: gosubset_prok +synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86] +synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] +synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86] +synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86] +xref: EC:3.2.1.86 +xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0008707 +name: 4-phytase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] +subset: gosubset_prok +synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] +synonym: "6-phytase activity" EXACT [] +synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26] +synonym: "phytase activity" BROAD [EC:3.1.3.26] +synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26] +xref: EC:3.1.3.26 +xref: MetaCyc:6-PHYT-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008709 +name: 7-alpha-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD+ = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH + H+." [EC:1.1.1.159] +subset: gosubset_prok +synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] +synonym: "7alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.159] +synonym: "7alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.159] +synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" EXACT [EC:1.1.1.159] +xref: EC:1.1.1.159 +xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008710 +name: 8-amino-7-oxononanoate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2." [EC:2.3.1.47] +subset: gosubset_prok +synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47] +synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47] +synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47] +synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47] +synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47] +synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47] +synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47] +synonym: "AONS activity" EXACT [EC:2.3.1.47] +xref: EC:2.3.1.47 +xref: MetaCyc:7KAPSYN-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0008711 +name: ADP-L-glycero-D-manno-heptose synthase activity +namespace: molecular_function +def: "OBSOLETE." [GOC:curators] +comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE). +is_obsolete: true +consider: GO:0033785 +consider: GO:0033786 + +[Term] +id: GO:0008712 +name: ADP-glyceromanno-heptose 6-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20] +subset: gosubset_prok +synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] +synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] +xref: EC:5.1.3.20 +xref: MetaCyc:5.1.3.20-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008713 +name: ADP-heptose-lipopolysaccharide heptosyltransferase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity + +[Term] +id: GO:0008714 +name: AMP nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + H2O = adenine + D-ribose 5-phosphate." [EC:3.2.2.4] +subset: gosubset_prok +synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4] +synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4] +synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4] +xref: EC:3.2.2.4 +xref: MetaCyc:AMP-NUCLEOSID-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008715 +name: CDP-diacylglycerol diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + H2O = CMP + phosphatidate." [EC:3.6.1.26] +subset: gosubset_prok +synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26] +synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26] +synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] +synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26] +xref: EC:3.6.1.26 +xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008716 +name: D-alanine-D-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine." [EC:6.3.2.4] +subset: gosubset_prok +synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4] +synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4] +synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4] +synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4] +synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4] +synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4] +xref: EC:6.3.2.4 +xref: MetaCyc:DALADALALIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008717 +name: D-alanyl-D-alanine endopeptidase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "penicillin-binding protein 7" NARROW [] +synonym: "penicillin-binding protein 8" NARROW [] +xref: EC:3.4.99.- +is_obsolete: true +replaced_by: GO:0004175 + +[Term] +id: GO:0008718 +name: D-amino-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1] +subset: gosubset_prok +synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] +synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] +xref: EC:1.4.99.1 +xref: MetaCyc:DAADEHYDROG-RXN +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0008719 +name: dihydroneopterin triphosphate 2'-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] +subset: gosubset_prok +synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] +xref: EC:5.-.-.- +xref: MetaCyc:H2NTPEPIM-RXN +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0008720 +name: D-lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.28] +subset: gosubset_prok +synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28] +synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28] +xref: EC:1.1.1.28 +xref: MetaCyc:DLACTDEHYDROGNAD-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008721 +name: D-serine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] +comment: Note that this function was formerly EC:4.3.1.14. +subset: gosubset_prok +synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] +synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18] +synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18] +synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] +synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] +synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] +synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] +synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] +synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] +xref: EC:4.3.1.18 +xref: MetaCyc:DSERDEAM-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008724 +name: DNA topoisomerase IV activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003918 + +[Term] +id: GO:0008725 +name: DNA-3-methyladenine glycosylase I activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] +subset: gosubset_prok +synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] +synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] +synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] +synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] +synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20] +xref: EC:3.2.2.20 +xref: MetaCyc:3.2.2.20-RXN +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0008726 +name: alkanesulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + SO3(2-) (sulfite) + H2O + FMN." [MetaCyc:RXN0-280] +subset: gosubset_prok +synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5] +synonym: "alkanesulphonate monooxygenase activity" EXACT [] +synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] +synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] +synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] +synonym: "SsuD" RELATED [EC:1.14.14.5] +synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] +xref: EC:1.14.14.5 +xref: MetaCyc:RXN0-280 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008727 +name: GDP-mannose mannosyl hydrolase activity +namespace: molecular_function +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0008728 +name: GTP diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] +subset: gosubset_prok +synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] +synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] +synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] +synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] +synonym: "GPSI" RELATED [EC:2.7.6.5] +synonym: "GPSII" RELATED [EC:2.7.6.5] +synonym: "GTP pyrophosphokinase activity" EXACT [] +synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5] +synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5] +synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5] +synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5] +synonym: "stringent factor activity" RELATED [EC:2.7.6.5] +xref: EC:2.7.6.5 +xref: MetaCyc:GTPPYPHOSKIN-RXN +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0008730 +name: L(+)-tartrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R,R)-tartrate = oxaloacetate + H2O." [EC:4.2.1.32] +subset: gosubset_prok +synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32] +synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32] +synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32] +synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32] +synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32] +synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32] +xref: EC:4.2.1.32 +xref: MetaCyc:LTARTDEHYDRA-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008732 +name: L-allo-threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760] +subset: gosubset_prok +synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] +synonym: "LtaA" RELATED [] +xref: EC:4.1.2.- +xref: MetaCyc:LTAA-RXN +is_a: GO:0004793 ! threonine aldolase activity + +[Term] +id: GO:0008733 +name: L-arabinose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4] +subset: gosubset_prok +synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4] +synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4] +xref: EC:5.3.1.4 +xref: MetaCyc:ARABISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008734 +name: L-aspartate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.16] +subset: gosubset_prok +synonym: "L-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.16] +xref: EC:1.4.3.16 +xref: MetaCyc:L-ASPARTATE-OXIDASE-RXN +is_a: GO:0015922 ! aspartate oxidase activity + +[Term] +id: GO:0008735 +name: carnitine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-carnitine = 4-(trimethylammonio)but-2-enoate + H2O." [EC:4.2.1.89] +subset: gosubset_prok +synonym: "L-carnitine dehydratase activity" EXACT [] +synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] +synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89] +xref: EC:4.2.1.89 +xref: MetaCyc:CARNDEHYDRA-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008736 +name: L-fucose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] +subset: gosubset_prok +synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25] +synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25] +xref: EC:5.3.1.25 +xref: MetaCyc:FUCISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008737 +name: L-fuculokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-fuculose = ADP + L-fuculose 1-phosphate." [EC:2.7.1.51] +subset: gosubset_prok +synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51] +synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51] +synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51] +xref: EC:2.7.1.51 +xref: MetaCyc:FUCULOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008738 +name: L-fuculose-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.17] +subset: gosubset_prok +synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17] +synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17] +synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17] +synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17] +xref: EC:4.1.2.17 +xref: MetaCyc:FUCPALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008740 +name: L-rhamnose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14] +subset: gosubset_prok +synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14] +synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14] +synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14] +xref: EC:5.3.1.14 +xref: MetaCyc:RHAMNISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008741 +name: ribulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] +subset: gosubset_prok +synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16] +synonym: "L-ribulokinase activity" EXACT [] +synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] +xref: EC:2.7.1.16 +xref: MetaCyc:RIBULOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008742 +name: L-ribulose-phosphate 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylose 5-phosphate." [EC:5.1.3.4] +subset: gosubset_prok +synonym: "AraD" RELATED [EC:5.1.3.4] +synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] +synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] +synonym: "L-Ru5P" RELATED [EC:5.1.3.4] +synonym: "L-ru5P activity" EXACT [EC:5.1.3.4] +synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4] +synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] +xref: EC:5.1.3.4 +xref: MetaCyc:RIBULPEPIM-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008743 +name: L-threonine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+." [EC:1.1.1.103] +subset: gosubset_prok +synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103] +synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103] +synonym: "threonine 3-dehydrogenase activity" BROAD [] +synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103] +xref: EC:1.1.1.103 +xref: MetaCyc:THREODEHYD-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008744 +name: L-xylulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] +subset: gosubset_prok +synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53] +synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53] +synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53] +xref: EC:2.7.1.53 +xref: MetaCyc:LYXK-RXN +is_a: GO:0004856 ! xylulokinase activity + +[Term] +id: GO:0008745 +name: N-acetylmuramoyl-L-alanine amidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] +subset: gosubset_prok +synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "murein hydrolase activity" EXACT [EC:3.5.1.28] +synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] +synonym: "peptidoglycan amidohydrolase activity" EXACT [EC:3.5.1.28] +xref: EC:3.5.1.28 +xref: MetaCyc:3.5.1.28-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008746 +name: NAD(P) transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] +subset: gosubset_prok +synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2] +synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +xref: EC:1.6.1.- +is_a: GO:0016652 ! oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor + +[Term] +id: GO:0008747 +name: N-acetylneuraminate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3] +subset: gosubset_prok +synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3] +synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3] +synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3] +synonym: "NALase activity" EXACT [EC:4.1.3.3] +synonym: "NANA lyase activity" EXACT [EC:4.1.3.3] +synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3] +synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3] +synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3] +synonym: "NPL" RELATED [EC:4.1.3.3] +synonym: "sialate lyase activity" EXACT [EC:4.1.3.3] +synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3] +synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3] +xref: EC:4.1.3.3 +xref: MetaCyc:ACNEULY-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008748 +name: N-ethylmaleimide reductase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0008750 +name: NAD(P)+ transhydrogenase (AB-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid=6006l3] +subset: gosubset_prok +synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2] +synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2] +synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] +synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] +xref: EC:1.6.1.2 +xref: MetaCyc:1.6.1.2-RXN +is_a: GO:0008746 ! NAD(P) transhydrogenase activity + +[Term] +id: GO:0008751 +name: NAD(P)H dehydrogenase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is a redundant grouping term with only one child. +is_obsolete: true +consider: GO:0016651 + +[Term] +id: GO:0008752 +name: FMN reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29] +subset: gosubset_prok +synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29] +synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29] +synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] +synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] +synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] +synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29] +synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "SsuE" RELATED [EC:1.5.1.29] +xref: EC:1.5.1.29 +xref: MetaCyc:FMNREDUCT-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008753 +name: NADPH dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.6] +subset: gosubset_prok +synonym: "NADPH oxidase" BROAD [EC:1.6.99.6] +synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.99.6] +synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.99.6] +xref: EC:1.6.99.6 +xref: MetaCyc:NADPH-DEHYDROGENASE-(QUINONE)-RXN +is_a: GO:0003959 ! NADPH dehydrogenase activity + +[Term] +id: GO:0008754 +name: O antigen ligase activity +namespace: molecular_function +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0008755 +name: O antigen polymerase activity +namespace: molecular_function +def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra and penta saccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "O-antigen polymerase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008756 +name: o-succinylbenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA." [EC:6.2.1.26] +subset: gosubset_prok +synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] +synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] +synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26] +synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26] +synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26] +synonym: "osb-CoA synthetase activity" EXACT [EC:6.2.1.26] +xref: EC:6.2.1.26 +xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0008757 +name: S-adenosylmethionine-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] +subset: gosubset_prok +synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] +synonym: "SAM-dependent methyltransferase activity" EXACT [] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008758 +name: UDP-2,3-diacylglucosamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] +subset: gosubset_prok +xref: EC:3.6.1.- +xref: MetaCyc:LIPIDXSYNTHESIS-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008759 +name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity +namespace: molecular_function +def: "Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] +subset: gosubset_prok +xref: EC:3.5.1.- +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0008760 +name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7] +subset: gosubset_prok +synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7] +synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] +synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] +synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7] +synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] +synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7] +synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] +synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7] +synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7] +synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7] +xref: EC:2.5.1.7 +xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008761 +name: UDP-N-acetylglucosamine 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] +subset: gosubset_prok +synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14] +synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14] +synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] +synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14] +synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] +synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] +xref: EC:5.1.3.14 +xref: MetaCyc:UDPGLCNACEPIM-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008762 +name: UDP-N-acetylmuramate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] +subset: gosubset_prok +synonym: "MurB reductase" RELATED [EC:1.1.1.158] +synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] +synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] +synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] +synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158] +synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158] +synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] +synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158] +xref: EC:1.1.1.158 +xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008763 +name: UDP-N-acetylmuramate-L-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8] +subset: gosubset_prok +synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] +synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] +synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] +synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] +synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] +synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8] +synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8] +synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] +synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] +synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] +synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] +xref: EC:6.3.2.8 +xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008764 +name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9] +subset: gosubset_prok +synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] +synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] +synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9] +synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9] +synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] +synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] +xref: EC:6.3.2.9 +xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008765 +name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13] +subset: gosubset_prok +synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13] +xref: EC:6.3.2.13 +xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008766 +name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15] +comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). +subset: gosubset_prok +xref: EC:6.3.2.- +xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008767 +name: UDP-galactopyranose mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] +subset: gosubset_prok +synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9] +synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9] +xref: EC:5.4.99.9 +xref: MetaCyc:GALPMUT-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0008768 +name: UDP-sugar diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] +subset: gosubset_prok +synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45] +synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] +synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45] +synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] +synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45] +xref: EC:3.6.1.45 +xref: MetaCyc:UDPSUGARHYDRO-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008769 +name: X-His dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3] +synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3] +synonym: "carnosinase activity" RELATED [EC:3.4.13.3] +synonym: "dipeptidase M" RELATED [EC:3.4.13.3] +synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] +synonym: "Xaa-His dipeptidase activity" EXACT [] +xref: EC:3.4.13.3 +xref: MetaCyc:3.4.13.3-RXN +is_obsolete: true +replaced_by: GO:0008235 +replaced_by: GO:0016805 + +[Term] +id: GO:0008770 +name: [acyl-carrier-protein] phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] +subset: gosubset_prok +synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] +synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] +synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14] +synonym: "ACP phosphodiesterase activity" EXACT [] +synonym: "AcpH" RELATED [EC:3.1.4.14] +synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] +synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] +synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] +xref: EC:3.1.4.14 +xref: MetaCyc:3.1.4.14-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0008771 +name: [citrate (pro-3S)-lyase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] +subset: gosubset_prok +synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22] +synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] +synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22] +synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22] +synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22] +synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] +xref: EC:6.2.1.22 +xref: MetaCyc:CITC-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0008772 +name: [isocitrate dehydrogenase (NADP+)] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] +subset: gosubset_prok +synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5] +synonym: "ICDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] +synonym: "IDH kinase activity" EXACT [EC:2.7.11.5] +synonym: "IDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] +synonym: "IDH-K/P" RELATED [EC:2.7.11.5] +synonym: "IDHK/P" RELATED [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5] +synonym: "STK3" RELATED [EC:2.7.11.5] +xref: EC:2.7.11.5 +xref: MetaCyc:PHOSICITDEHASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0008773 +name: [protein-PII] uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] +subset: gosubset_prok +synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59] +synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] +synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] +synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] +synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] +synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] +xref: EC:2.7.7.59 +xref: MetaCyc:URITRANS-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008774 +name: acetaldehyde dehydrogenase (acetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] +subset: gosubset_prok +synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10] +synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10] +synonym: "ADA" RELATED [EC:1.2.1.10] +synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10] +synonym: "DmpF" RELATED [EC:1.2.1.10] +xref: EC:1.2.1.10 +xref: MetaCyc:ACETALD-DEHYDROG-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008775 +name: acetate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] +subset: gosubset_prok +synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8] +synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8] +synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8] +synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] +synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8] +synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] +xref: EC:2.8.3.8 +xref: MetaCyc:ACECOATRANS-RXN +xref: UM-BBD_enzymeID:e0012 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008776 +name: acetate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] +subset: gosubset_prok +synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1] +synonym: "acetic kinase activity" EXACT [EC:2.7.2.1] +synonym: "acetokinase activity" EXACT [EC:2.7.2.1] +synonym: "AckA" RELATED [EC:2.7.2.1] +synonym: "AK activity" EXACT [EC:2.7.2.1] +synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] +xref: EC:2.7.2.1 +xref: MetaCyc:ACETATEKIN-RXN +xref: UM-BBD_enzymeID:e0031 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0008777 +name: acetylornithine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] +subset: gosubset_prok +synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] +synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] +synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] +synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] +xref: EC:3.5.1.16 +xref: MetaCyc:ACETYLORNDEACET-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0008779 +name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] +synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] +synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] +synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40] +synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] +xref: EC:2.3.1.40 +xref: MetaCyc:ACYLGPEACYLTRANS-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0008780 +name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] +subset: gosubset_prok +synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129] +synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] +synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] +synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] +synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] +synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] +xref: EC:2.3.1.129 +xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0008781 +name: N-acylneuraminate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] +subset: gosubset_prok +synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43] +synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43] +synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] +synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] +synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] +synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] +synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43] +synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] +synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43] +synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] +xref: EC:2.7.7.43 +xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008782 +name: adenosylhomocysteine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] +subset: gosubset_prok +synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9] +synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9] +synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9] +synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] +synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] +synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] +xref: EC:3.2.2.9 +xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008783 +name: agmatinase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + H2O = putrescine + urea." [EC:3.5.3.11] +subset: gosubset_prok +synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] +synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11] +synonym: "SpeB" RELATED [EC:3.5.3.11] +xref: EC:3.5.3.11 +xref: MetaCyc:AGMATIN-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0008784 +name: alanine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1] +subset: gosubset_prok +synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1] +xref: EC:5.1.1.1 +xref: MetaCyc:ALARACECAT-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0008785 +name: alkyl hydroperoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_enzymeID:e0429] +subset: gosubset_prok +xref: EC:1.6.4.- +xref: UM-BBD_enzymeID:e0429 +is_a: GO:0016654 ! oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor + +[Term] +id: GO:0008786 +name: allose 6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] +xref: EC:5.3.1.- +xref: MetaCyc:RXN0-303 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008787 +name: allose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] +subset: gosubset_prok +synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55] +synonym: "allokinase activity" EXACT [EC:2.7.1.55] +synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55] +synonym: "D-allokinase activity" EXACT [EC:2.7.1.55] +synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55] +xref: EC:2.7.1.55 +xref: MetaCyc:ALLOSE-KINASE-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008788 +name: alpha,alpha-phosphotrehalase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] +subset: gosubset_prok +synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93] +synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93] +synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93] +xref: EC:3.2.1.93 +xref: MetaCyc:TRE6PHYDRO-RXN +is_a: GO:0015927 ! trehalase activity + +[Term] +id: GO:0008789 +name: altronate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.7] +subset: gosubset_prok +synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7] +synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7] +xref: EC:4.2.1.7 +xref: MetaCyc:ALTRODEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008790 +name: arabinose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] +synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3] +synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] +synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3] +synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3] +xref: EC:5.3.1.3 +xref: MetaCyc:DARABISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008791 +name: arginine N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] +subset: gosubset_prok +synonym: "AOST activity" EXACT [EC:2.3.1.109] +synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109] +synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] +synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109] +synonym: "AST activity" EXACT [EC:2.3.1.109] +synonym: "AstA" RELATED [EC:2.3.1.109] +synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109] +synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] +xref: EC:2.3.1.109 +xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN +is_a: GO:0016749 ! N-succinyltransferase activity + +[Term] +id: GO:0008792 +name: arginine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine = agmatine + CO2." [EC:4.1.1.19] +subset: gosubset_prok +synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19] +synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19] +synonym: "SpeA" RELATED [EC:4.1.1.19] +xref: EC:4.1.1.19 +xref: MetaCyc:ARGDECARBOX-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008793 +name: aromatic-amino-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] +subset: gosubset_prok +synonym: "ArAT" RELATED [EC:2.6.1.57] +synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57] +synonym: "aromatic amino acid transferase activity" EXACT [] +synonym: "aromatic aminotransferase activity" EXACT [] +synonym: "aromatic-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.57] +xref: EC:2.6.1.57 +xref: UM-BBD_enzymeID:e0142 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0008794 +name: arsenate reductase (glutaredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] +subset: gosubset_prok +synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] +xref: EC:1.20.4.1 +xref: MetaCyc:RXN-982 +xref: UM-BBD_enzymeID:e0261 +is_a: GO:0030611 ! arsenate reductase activity +is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor + +[Term] +id: GO:0008795 +name: NAD+ synthase activity +namespace: molecular_function +alt_id: GO:0008749 +alt_id: GO:0016965 +def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] +subset: gosubset_prok +synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5] +synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5] +synonym: "NAD synthase (AMP-forming)" EXACT [] +synonym: "NAD synthase activity" EXACT [] +synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5] +synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5] +synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5] +synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5] +xref: EC:6.3.1.5 +xref: MetaCyc:NAD-SYNTH-NH3-RXN +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0008796 +name: bis(5'-nucleosyl)-tetraphosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] +subset: gosubset_prok +xref: EC:3.6.1.- +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0008797 +name: aspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] +subset: gosubset_prok +synonym: "aspartase activity" EXACT [EC:4.3.1.1] +synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1] +synonym: "L-aspartase activity" EXACT [EC:4.3.1.1] +synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1] +synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1] +xref: EC:4.3.1.1 +xref: MetaCyc:ASPARTASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008798 +name: beta-aspartyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] +subset: gosubset_prok +synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5] +synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5] +xref: EC:3.4.19.5 +xref: MetaCyc:3.4.19.5-RXN +is_a: GO:0008242 ! omega peptidase activity + +[Term] +id: GO:0008800 +name: beta-lactamase activity +namespace: molecular_function +def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] +subset: gosubset_prok +synonym: "ampicillinase activity" EXACT [EC:3.5.2.6] +synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6] +synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] +synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] +synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] +synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6] +synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6] +synonym: "neutrapen" RELATED [EC:3.5.2.6] +synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6] +synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] +synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] +xref: EC:3.5.2.6 +xref: MetaCyc:BETA-LACTAMASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0008801 +name: beta-phosphoglucomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6] +subset: gosubset_prok +synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6] +xref: EC:5.4.2.6 +xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008802 +name: betaine-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] +subset: gosubset_prok +synonym: "BADH activity" EXACT [EC:1.2.1.8] +synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8] +synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8] +synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8] +synonym: "BetB" RELATED [EC:1.2.1.8] +xref: EC:1.2.1.8 +xref: MetaCyc:BADH-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008803 +name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity +namespace: molecular_function +def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = 2 NDP." [EC:3.6.1.41, PMID:6317672] +subset: gosubset_prok +synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] +synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41] +synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] +synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] +synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41] +synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] +synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41] +synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] +synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] +synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] +synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] +synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] +synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] +synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] +xref: EC:3.6.1.41 +xref: MetaCyc:3.6.1.41-RXN +is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity + +[Term] +id: GO:0008804 +name: carbamate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] +subset: gosubset_prok +synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2] +synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2] +synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2] +synonym: "CKase activity" EXACT [EC:2.7.2.2] +xref: EC:2.7.2.2 +xref: MetaCyc:CARBAMATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0008805 +name: carbon-monoxide oxygenase activity +namespace: molecular_function +alt_id: GO:0018999 +alt_id: GO:0047767 +def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] +synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4] +synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4] +synonym: "carbon monoxide oxygenase activity" EXACT [] +synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4] +synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4] +synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] +synonym: "cytochrome b561" NARROW [] +xref: EC:1.2.2.4 +xref: MetaCyc:1.2.2.4-RXN +xref: UM-BBD_enzymeID:e0180 +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0008806 +name: carboxymethylenebutenolidase activity +namespace: molecular_function +alt_id: GO:0018735 +def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] +subset: gosubset_prok +synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45] +synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45] +synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45] +synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45] +xref: EC:3.1.1.45 +xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN +xref: UM-BBD_enzymeID:e0066 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0008807 +name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] +subset: gosubset_prok +synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23] +synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23] +synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23] +xref: EC:2.7.8.23 +xref: MetaCyc:2.7.8.23-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008808 +name: cardiolipin synthase activity +namespace: molecular_function +def: "Phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl] +subset: gosubset_prok +synonym: "cardiolipin synthetase activity" BROAD [] +synonym: "diphosphatidylglycerol synthase activity" EXACT [] +xref: EC:2.7.8.- +xref: MetaCyc:CARDIOLIPSYN-RXN +is_a: GO:0030572 ! phosphatidyltransferase activity + +[Term] +id: GO:0008809 +name: carnitine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] +xref: EC:5.1.-.- +xref: MetaCyc:CARNRACE-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0008810 +name: cellulase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] +subset: gosubset_prok +synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4] +synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4] +synonym: "alkali cellulase activity" EXACT [EC:3.2.1.4] +synonym: "avicelase activity" BROAD [EC:3.2.1.4] +synonym: "beta-1,4-endoglucan hydrolase activity" EXACT [EC:3.2.1.4] +synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] +synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] +synonym: "celluase A" RELATED [EC:3.2.1.4] +synonym: "celludextrinase activity" EXACT [EC:3.2.1.4] +synonym: "cellulase A 3" RELATED [EC:3.2.1.4] +synonym: "cellulosin AP" RELATED [EC:3.2.1.4] +synonym: "endo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.4] +synonym: "endo-1,4-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.4] +synonym: "endo-1,4-beta-glucanase activity" EXACT [EC:3.2.1.4] +synonym: "endoglucanase activity" EXACT [EC:3.2.1.4] +synonym: "endoglucanase D" RELATED [EC:3.2.1.4] +synonym: "pancellase SS" RELATED [EC:3.2.1.4] +xref: EC:3.2.1.4 +xref: MetaCyc:3.2.1.4-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0008811 +name: chloramphenicol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate." [EC:2.3.1.28] +subset: gosubset_prok +synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28] +synonym: "CAT I" RELATED [EC:2.3.1.28] +synonym: "CAT II" RELATED [EC:2.3.1.28] +synonym: "CAT III" RELATED [EC:2.3.1.28] +synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28] +synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28] +synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28] +xref: EC:2.3.1.28 +xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0008812 +name: choline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline + acceptor = betaine aldehyde + reduced acceptor." [EC:1.1.99.1] +subset: gosubset_prok +synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] +synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] +synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1] +synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1] +synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1] +xref: EC:1.1.99.1 +xref: MetaCyc:CHD-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0008813 +name: chorismate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, IMG:00552, MetaCyc:CHORPYRLY-RXN] +subset: gosubset_prok +synonym: "4-hydroxybenzoate synthetase activity" EXACT [] +synonym: "chorismate pyruvate lyase activity" EXACT [] +synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40] +synonym: "CL" RELATED [EC:4.1.3.40] +synonym: "CPL" RELATED [EC:4.1.3.40] +synonym: "UbiC" RELATED [EC:4.1.3.40] +xref: EC:4.1.3.40 +xref: MetaCyc:CHORPYRLY-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008814 +name: citrate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] +subset: gosubset_prok +synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10] +xref: EC:2.8.3.10 +xref: MetaCyc:CITTRANS-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008815 +name: citrate (pro-3S)-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6] +subset: gosubset_prok +synonym: "citrase activity" EXACT [EC:4.1.3.6] +synonym: "citratase activity" EXACT [EC:4.1.3.6] +synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6] +synonym: "citrate lyase activity" EXACT [] +synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] +synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6] +synonym: "citric aldolase activity" EXACT [EC:4.1.3.6] +synonym: "citridesmolase activity" EXACT [EC:4.1.3.6] +synonym: "citritase activity" EXACT [EC:4.1.3.6] +xref: EC:4.1.3.6 +xref: MetaCyc:CITLY-RXN +xref: Reactome:26375 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008816 +name: citryl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] +subset: gosubset_prok +synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34] +synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34] +xref: EC:4.1.3.34 +xref: MetaCyc:CITRYLY-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008817 +name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] +subset: gosubset_prok +synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17] +synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17] +synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] +synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] +synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17] +synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] +synonym: "CobA" RELATED [EC:2.5.1.17] +synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17] +xref: EC:2.5.1.17 +xref: MetaCyc:COBALADENOSYLTRANS-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008818 +name: cobalamin 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] +subset: gosubset_prok +xref: MetaCyc:COBALAMIN5PSYN-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008819 +name: cobinamide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] +subset: gosubset_prok +xref: EC:2.7.1.- +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008820 +name: cobinamide phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide-phosphate + GTP = adenosylcobinamide-GDP + diphosphate." [MetaCyc:COBINPGUANYLYLTRANS-RXN] +subset: gosubset_prok +synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] +xref: MetaCyc:COBINPGUANYLYLTRANS-RXN +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0008821 +name: crossover junction endodeoxyribonuclease activity +namespace: molecular_function +alt_id: GO:0008844 +def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] +synonym: "crossover junction endoribonuclease activity" EXACT [] +synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] +synonym: "endo X3" RELATED [EC:3.1.22.4] +synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] +synonym: "endodeoxyribonuclease RUS activity" EXACT [] +synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] +synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] +synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] +synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] +synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] +synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] +synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] +synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] +synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] +synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] +synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] +synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] +synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] +synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] +synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] +synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] +xref: EC:3.1.22.- +xref: EC:3.1.22.4 +xref: MetaCyc:3.1.22.4-RXN +is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0008822 +name: crotonobetaine/carnitine-CoA ligase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a bifunctional gene product. +is_obsolete: true +replaced_by: GO:0051108 +replaced_by: GO:0051109 + +[Term] +id: GO:0008823 +name: cupric reductase activity +namespace: molecular_function +xref: EC:1.16.1.- +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0008824 +name: cyanate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-)." [EC:4.2.1.104] +comment: Note that this function was formerly EC:4.3.99.1. +subset: gosubset_prok +synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104] +synonym: "cyanase activity" EXACT [] +synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104] +synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104] +synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104] +synonym: "cyanate lyase activity" EXACT [] +xref: EC:4.2.1.104 +xref: MetaCyc:4.3.99.1-RXN +xref: UM-BBD_enzymeID:e0396 +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0008825 +name: cyclopropane-fatty-acyl-phospholipid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] +subset: gosubset_prok +synonym: "CFA synthase activity" EXACT [EC:2.1.1.79] +synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79] +synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79] +synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79] +synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] +synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79] +synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] +xref: EC:2.1.1.79 +xref: MetaCyc:2.1.1.79-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008826 +name: cysteine sulfinate desulfinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + SO3(2-)." [MetaCyc:RXN0-279] +synonym: "cysteine sulphinate desulphinase activity" EXACT [] +xref: EC:4.4.1.- +xref: MetaCyc:RXN0-279 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0008827 +name: cytochrome o ubiquinol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2R; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN] +subset: gosubset_prok +xref: EC:1.10.3.- +is_a: GO:0015002 ! heme-copper terminal oxidase activity +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0008828 +name: dATP pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384] +subset: gosubset_prok +xref: EC:3.6.1.- +xref: MetaCyc:RXN0-384 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0008829 +name: dCTP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] +subset: gosubset_prok +synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13] +synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13] +synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13] +xref: EC:3.5.4.13 +xref: MetaCyc:DCTP-DEAM-RXN +xref: Reactome:26405 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008830 +name: dTDP-4-dehydrorhamnose 3,5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13] +subset: gosubset_prok +synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] +synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] +synonym: "dTDP-L-rhamnose synthetase activity" EXACT [EC:5.1.3.13] +synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13] +synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13] +synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] +xref: EC:5.1.3.13 +xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008831 +name: dTDP-4-dehydrorhamnose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+." [EC:1.1.1.133] +subset: gosubset_prok +synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133] +synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] +synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133] +synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133] +synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133] +synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133] +synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] +xref: EC:1.1.1.133 +xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008832 +name: dGTPase activity +namespace: molecular_function +def: "Catalysis of the reaction: dGTP + H2O = deoxyguanosine + triphosphate." [EC:3.1.5.1] +subset: gosubset_prok +synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1] +synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] +synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1] +synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] +synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] +synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1] +xref: EC:3.1.5.1 +xref: MetaCyc:DGTPTRIPHYDRO-RXN +is_a: GO:0016793 ! triphosphoric monoester hydrolase activity + +[Term] +id: GO:0008833 +name: deoxyribonuclease IV (phage-T4-induced) activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] +subset: gosubset_prok +synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2] +synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] +synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2] +synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] +synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2] +synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] +synonym: "endonuclease II" RELATED [EC:3.1.21.2] +synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] +synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] +synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2] +xref: EC:3.1.21.2 +xref: MetaCyc:3.1.21.2-RXN +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008834 +name: di-trans,poly-cis-decaprenylcistransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] +subset: gosubset_prok +synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] +synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31] +synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] +synonym: "undecaprenyl diphosphate synthase activity" EXACT [] +synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31] +synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31] +synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31] +synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] +synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31] +xref: EC:2.5.1.31 +xref: MetaCyc:DECAPCISTRANSFER-RXN +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0008835 +name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity +namespace: molecular_function +alt_id: GO:0008485 +def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3." [EC:3.5.4.26] +subset: gosubset_prok +synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] +synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] +synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] +xref: EC:3.5.4.26 +xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008836 +name: diaminopimelate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2." [EC:4.1.1.20] +subset: gosubset_prok +synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20] +synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20] +synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20] +synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20] +synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20] +synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20] +xref: EC:4.1.1.20 +xref: MetaCyc:DIAMINOPIMDECARB-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008837 +name: diaminopimelate epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate." [EC:5.1.1.7] +subset: gosubset_prok +synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7] +xref: EC:5.1.1.7 +xref: MetaCyc:DIAMINOPIMEPIM-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0008838 +name: diaminopropionate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] +subset: gosubset_prok +synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15] +synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] +synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] +synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15] +xref: EC:4.3.1.15 +xref: MetaCyc:4.3.1.15-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008839 +name: dihydrodipicolinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+." [EC:1.3.1.26] +subset: gosubset_prok +synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26] +synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26] +xref: EC:1.3.1.26 +xref: MetaCyc:DIHYDROPICRED-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008840 +name: dihydrodipicolinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O." [EC:4.2.1.52] +subset: gosubset_prok +synonym: "DHDPS activity" EXACT [EC:4.2.1.52] +synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52] +synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52] +synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52] +synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52] +synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] +xref: EC:4.2.1.52 +xref: MetaCyc:DIHYDRODIPICSYN-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008841 +name: dihydrofolate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] +subset: gosubset_prok +synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] +synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12] +synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12] +synonym: "DHFS activity" EXACT [EC:6.3.2.12] +synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] +synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12] +synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12] +synonym: "FHFS activity" EXACT [EC:6.3.2.12] +synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12] +synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12] +synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12] +synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12] +xref: EC:6.3.2.12 +xref: MetaCyc:DIHYDROFOLATESYNTH-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008842 +name: diphosphate-purine nucleoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] +synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] +synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143] +synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] +synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143] +xref: EC:2.7.1.143 +xref: MetaCyc:2.7.1.143-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0008843 +name: endochitinase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin and chitodextrins." [EC:3.2.1.14] +is_a: GO:0004568 ! chitinase activity + +[Term] +id: GO:0008845 +name: endonuclease VIII activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12713806] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0000703 +consider: GO:0003684 +consider: GO:0003906 +consider: GO:0004519 +consider: GO:0008081 +consider: GO:0019104 + +[Term] +id: GO:0008846 +name: endopeptidase La activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53] +synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53] +synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53] +synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53] +synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53] +synonym: "gene lon protease activity" EXACT [EC:3.4.21.53] +synonym: "gene lon proteins" RELATED [EC:3.4.21.53] +synonym: "lon proteinase" NARROW [EC:3.4.21.53] +synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53] +synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] +synonym: "protease La" RELATED [EC:3.4.21.53] +synonym: "proteinase La" RELATED [EC:3.4.21.53] +synonym: "serine protease La" RELATED [EC:3.4.21.53] +xref: EC:3.4.21.53 +xref: MetaCyc:3.4.21.53-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008847 +name: Enterobacter ribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6] +subset: gosubset_prok +synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6] +synonym: "Enterobacter RNase activity" EXACT [] +xref: EC:3.1.27.6 +xref: MetaCyc:3.1.27.6-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0008848 +name: enterobactin synthetase +namespace: molecular_function +alt_id: GO:0008850 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a process rather than a function. +synonym: "enterochelin synthetase activity" EXACT [] +synonym: "nonribosomal peptide synthetase" RELATED [] +is_obsolete: true +replaced_by: GO:0009239 + +[Term] +id: GO:0008849 +name: enterochelin esterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the enterochelin moiety of ferric-enterochelin to yield ultimately three molecules of N-2,3-dihydroxybenzoylserine." [PMID:4565531] +synonym: "enterobactin esterase activity" EXACT [] +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0008851 +name: ethanolamine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] +subset: gosubset_prok +synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7] +synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7] +xref: EC:4.3.1.7 +xref: MetaCyc:ETHAMLY-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008852 +name: exodeoxyribonuclease I activity +namespace: molecular_function +def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] +subset: gosubset_prok +synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1] +synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] +synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] +synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] +xref: EC:3.1.11.1 +xref: MetaCyc:3.1.11.1-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008853 +name: exodeoxyribonuclease III activity +namespace: molecular_function +def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] +subset: gosubset_prok +synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2] +synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] +synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] +synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] +synonym: "exonuclease III activity" EXACT [EC:3.1.11.2] +xref: EC:3.1.11.2 +xref: MetaCyc:3.1.11.2-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008854 +name: exodeoxyribonuclease V activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] +subset: gosubset_prok +synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5] +synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] +synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] +synonym: "exonuclease V activity" EXACT [EC:3.1.11.5] +synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5] +synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] +synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] +synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5] +xref: EC:3.1.11.5 +xref: MetaCyc:3.1.11.5-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008855 +name: exodeoxyribonuclease VII activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] +subset: gosubset_prok +synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6] +synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] +synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] +synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] +synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6] +xref: EC:3.1.11.6 +xref: MetaCyc:3.1.11.6-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008856 +name: exodeoxyribonuclease X activity +namespace: molecular_function +def: "Catalysis of the reaction: Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] +synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5] +synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] +synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] +xref: EC:3.1.11.- +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008857 +name: exonuclease IX activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0008858 +name: exonuclease VIII activity +namespace: molecular_function +xref: EC:3.1.11.- +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008859 +name: exoribonuclease II activity +namespace: molecular_function +def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] +subset: gosubset_prok +synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1] +synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1] +synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] +synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1] +synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] +synonym: "RNase II" RELATED [EC:3.1.13.1] +synonym: "RNase II activity" EXACT [] +xref: EC:3.1.13.1 +xref: MetaCyc:3.1.13.1-RXN +is_a: GO:0008408 ! 3'-5' exonuclease activity +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008860 +name: ferredoxin-NAD+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3] +subset: gosubset_prok +synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3] +synonym: "ferredoxin-NAD reductase activity" EXACT [] +synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3] +synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3] +synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3] +synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3] +synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] +synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3] +synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3] +synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3] +synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] +synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] +xref: EC:1.18.1.3 +xref: MetaCyc:FERREDOXIN--NAD(+)-REDUCTASE-RXN +is_a: GO:0008937 ! ferredoxin reductase activity + +[Term] +id: GO:0008861 +name: formate C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] +subset: gosubset_prok +synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54] +synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54] +synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54] +synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54] +xref: EC:2.3.1.54 +xref: MetaCyc:PYRUVFORMLY-RXN +is_a: GO:0016453 ! C-acetyltransferase activity + +[Term] +id: GO:0008863 +name: formate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0018476 +def: "Catalysis of the reaction: formate + NAD+ = CO2 + NADH + H+." [EC:1.2.1.2] +subset: gosubset_prok +synonym: "FDH I" RELATED [EC:1.2.1.2] +synonym: "FDH II" RELATED [EC:1.2.1.2] +synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2] +synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2] +synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2] +synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2] +synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2] +synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2] +synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2] +synonym: "N-FDH" RELATED [EC:1.2.1.2] +synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2] +synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2] +synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2] +xref: EC:1.2.1.2 +xref: MetaCyc:FORMATEDEHYDROG-RXN +xref: UM-BBD_enzymeID:e0080 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008864 +name: formyltetrahydrofolate deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate." [EC:3.5.1.10] +subset: gosubset_prok +synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10] +synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10] +synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10] +xref: EC:3.5.1.10 +xref: MetaCyc:FORMYLTHFDEFORMYL-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008865 +name: fructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] +subset: gosubset_prok +synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4] +synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4] +synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4] +synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4] +xref: EC:2.7.1.4 +xref: MetaCyc:FRUCTOKINASE-RXN +is_a: GO:0004396 ! hexokinase activity + +[Term] +id: GO:0008866 +name: fructuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+." [EC:1.1.1.57] +subset: gosubset_prok +synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57] +synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] +synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57] +synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57] +synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] +synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57] +xref: EC:1.1.1.57 +xref: MetaCyc:MANNONOXIDOREDUCT-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008867 +name: galactarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.42] +subset: gosubset_prok +synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42] +synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42] +xref: EC:4.2.1.42 +xref: MetaCyc:GALACTARDEHYDRA-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008868 +name: galactitol-1-phosphate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] +subset: gosubset_prok +synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251] +xref: EC:1.1.1.251 +xref: MetaCyc:1.1.1.251-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008869 +name: galactonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O." [EC:4.2.1.6] +subset: gosubset_prok +synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6] +synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6] +synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6] +synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6] +xref: EC:4.2.1.6 +xref: MetaCyc:GALACTONDEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008870 +name: galactoside O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] +subset: gosubset_prok +synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18] +synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18] +synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] +synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] +xref: EC:2.3.1.18 +xref: MetaCyc:GALACTOACETYLTRAN-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0008871 +name: aminoglycoside 2''-nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] +subset: gosubset_prok +synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46] +synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] +synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] +synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] +synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] +xref: EC:2.7.7.46 +xref: MetaCyc:2.7.7.46-RXN +is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity + +[Term] +id: GO:0008872 +name: glucarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] +subset: gosubset_prok +synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40] +synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40] +synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40] +xref: EC:4.2.1.40 +xref: MetaCyc:GLUCARDEHYDRA-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008873 +name: gluconate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] +subset: gosubset_prok +synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215] +synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215] +synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215] +xref: EC:1.1.1.215 +xref: MetaCyc:1.1.1.215-RXN +is_a: GO:0008875 ! gluconate dehydrogenase activity + +[Term] +id: GO:0008874 +name: gluconate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] +subset: gosubset_prok +synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69] +synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69] +synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69] +synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69] +synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69] +xref: EC:1.1.1.69 +xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN +is_a: GO:0008875 ! gluconate dehydrogenase activity + +[Term] +id: GO:0008875 +name: gluconate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] +subset: gosubset_prok +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008876 +name: quinoprotein glucose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] +comment: Note that this was EC:1.1.99.17. +subset: gosubset_prok +synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2] +synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2] +synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2] +synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] +synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2] +xref: EC:1.1.5.2 +xref: MetaCyc:GLUCDEHYDROG-RXN +is_a: GO:0004344 ! glucose dehydrogenase activity +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0008877 +name: glucose-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] +subset: gosubset_prok +synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] +synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] +xref: EC:3.1.3.10 +xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0008878 +name: glucose-1-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose." [EC:2.7.7.27] +subset: gosubset_prok +synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] +synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] +synonym: "ADGase activity" EXACT [] +synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] +synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27] +synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] +synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27] +synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27] +synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] +synonym: "ADPG pyrophosphorylase activity" EXACT [] +synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] +synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] +synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] +xref: EC:2.7.7.27 +xref: MetaCyc:GLUC1PADENYLTRANS-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008879 +name: glucose-1-phosphate thymidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose." [EC:2.7.7.24] +subset: gosubset_prok +synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24] +synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] +synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24] +synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] +synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] +synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] +synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] +synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] +xref: EC:2.7.7.24 +xref: MetaCyc:DTDPGLUCOSEPP-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008880 +name: glucuronate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] +subset: gosubset_prok +synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12] +synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12] +synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12] +synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12] +synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12] +synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12] +xref: EC:5.3.1.12 +xref: MetaCyc:GLUCUROISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008881 +name: glutamate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3] +subset: gosubset_prok +xref: EC:5.1.1.3 +xref: MetaCyc:GLUTRACE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0008882 +name: [glutamate-ammonia-ligase] adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (L-glutamate:ammonia ligase (ADP-forming)) = diphosphate + adenylyl-(L-glutamate:ammonia ligase (ADP-forming))." [EC:2.7.7.42] +subset: gosubset_prok +synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] +synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] +synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] +synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42] +synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] +synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] +xref: EC:2.7.7.42 +xref: MetaCyc:GSADENYLATION-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008883 +name: glutamyl-tRNA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+." [EC:1.2.1.70, MetaCyc:GLUTRNAREDUCT-RXN] +subset: gosubset_prok +synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70] +xref: EC:1.2.1.70 +xref: MetaCyc:GLUTRNAREDUCT-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008884 +name: glutathionylspermidine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] +subset: gosubset_prok +synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78] +synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78] +synonym: "GSP amidase activity" EXACT [EC:3.5.1.78] +xref: EC:3.5.1.78 +xref: MetaCyc:GSPAMID-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008885 +name: glutathionylspermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] +subset: gosubset_prok +synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] +synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] +synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] +synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8] +synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8] +xref: EC:6.3.1.8 +xref: MetaCyc:GSPSYN-RXN +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0008886 +name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+." [EC:1.2.1.9] +subset: gosubset_prok +synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] +synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] +synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] +synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] +synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] +synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] +synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] +xref: EC:1.2.1.9 +xref: MetaCyc:1.2.1.9-RXN +is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity + +[Term] +id: GO:0008887 +name: glycerate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate." [EC:2.7.1.31] +subset: gosubset_prok +synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31] +synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31] +synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31] +synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31] +synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31] +synonym: "GK" RELATED [EC:2.7.1.31] +synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31] +synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31] +xref: EC:2.7.1.31 +xref: MetaCyc:GLY3KIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008888 +name: glycerol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + NAD+ = glycerone + NADH + H+." [EC:1.1.1.6] +subset: gosubset_prok +synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] +xref: EC:1.1.1.6 +xref: MetaCyc:GLYCDEH-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008889 +name: glycerophosphodiester phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] +subset: gosubset_prok +synonym: "gene hpd protein" RELATED [EC:3.1.4.46] +synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46] +synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46] +synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] +xref: EC:3.1.4.46 +xref: MetaCyc:GLYCPDIESTER-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0008890 +name: glycine C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate." [EC:2.3.1.29] +subset: gosubset_prok +synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29] +synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29] +synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29] +synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29] +synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29] +synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29] +xref: EC:2.3.1.29 +xref: MetaCyc:AKBLIG-RXN +is_a: GO:0016453 ! C-acetyltransferase activity + +[Term] +id: GO:0008891 +name: glycolate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + H2O2." [EC:1.1.3.15] +subset: gosubset_prok +xref: MetaCyc:RXN-969 +is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity + +[Term] +id: GO:0008892 +name: guanine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] +subset: gosubset_prok +synonym: "GAH activity" EXACT [EC:3.5.4.3] +synonym: "guanase activity" EXACT [EC:3.5.4.3] +synonym: "guanine aminase activity" EXACT [EC:3.5.4.3] +synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3] +xref: EC:3.5.4.3 +xref: MetaCyc:GUANINE-DEAMINASE-RXN +xref: Reactome:26482 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008893 +name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] +subset: gosubset_prok +synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2] +synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] +synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2] +synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] +synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2] +synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] +synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2] +synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] +xref: EC:3.1.7.2 +xref: MetaCyc:PPGPPSYN-RXN +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0008894 +name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] +subset: gosubset_prok +synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40] +synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] +synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40] +synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40] +synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40] +synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] +synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] +synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] +xref: EC:3.6.1.40 +xref: MetaCyc:PPPGPPHYDRO-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008895 +name: heme lyase disulfide oxidoreductase activity +namespace: molecular_function +synonym: "haem lyase disulfide oxidoreductase activity" EXACT [] +synonym: "heme lyase disulphide oxidoreductase activity" EXACT [] +is_a: GO:0015035 ! protein disulfide oxidoreductase activity + +[Term] +id: GO:0008897 +name: holo-[acyl-carrier-protein] synthase activity +namespace: molecular_function +alt_id: GO:0008958 +def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] +subset: gosubset_prok +synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] +synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] +synonym: "AcpS" RELATED [EC:2.7.8.7] +synonym: "ACPS activity" RELATED [EC:2.7.8.7] +synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7] +synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] +synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] +synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] +synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] +synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] +synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] +synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] +synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7] +synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW [] +synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] +synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] +synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] +synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7] +synonym: "holosynthase activity" RELATED [EC:2.7.8.7] +synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] +synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7] +synonym: "phosphopantetheinyltransferase activity" EXACT [] +synonym: "PPTase activity" EXACT [EC:2.7.8.7] +xref: EC:2.7.8.7 +xref: MetaCyc:HOLO-ACP-SYNTH-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008898 +name: homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10] +subset: gosubset_prok +synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10] +synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "homocysteine transmethylase activity" EXACT [EC:2.1.1.10] +synonym: "L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] +synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10] +synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] +synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] +xref: EC:2.1.1.10 +xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008899 +name: homoserine O-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine." [EC:2.3.1.46] +subset: gosubset_prok +synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] +synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46] +synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46] +xref: EC:2.3.1.46 +xref: MetaCyc:HOMSUCTRAN-RXN +is_a: GO:0016750 ! O-succinyltransferase activity + +[Term] +id: GO:0008900 +name: hydrogen:potassium-exchanging ATPase activity +namespace: molecular_function +alt_id: GO:0005390 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10] +synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10] +synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] +synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10] +synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10] +synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10] +synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10] +synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10] +synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] +synonym: "h+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] +synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10] +synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] +synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] +synonym: "proton pump activity" BROAD [EC:3.6.3.10] +xref: EC:3.6.3.10 +xref: MetaCyc:3.6.3.10-RXN +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0008901 +name: ferredoxin hydrogenase activity +namespace: molecular_function +alt_id: GO:0016948 +alt_id: GO:0016949 +alt_id: GO:0016950 +alt_id: GO:0016951 +def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] +comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1. +subset: gosubset_prok +synonym: "[Fe] hydrogenase activity" EXACT [] +synonym: "[Fe] hydrogenase gamma" RELATED [] +synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] +synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] +synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] +synonym: "H2 oxidizing hydrogenase" BROAD [] +synonym: "H2 producing hydrogenase" BROAD [] +synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] +synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] +synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2] +synonym: "hydrogenase activity" BROAD [] +synonym: "hydrogenase I" RELATED [] +synonym: "hydrogenase II" RELATED [] +synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] +synonym: "iron hydrogenase activity" NARROW [] +synonym: "iron-only hydrogenase activity" NARROW [] +synonym: "Ni-Fe hydrogenase activity" NARROW [] +synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] +synonym: "nickel hydrogenase activity" NARROW [] +synonym: "nickel-iron hydrogenase activity" NARROW [] +synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] +synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] +xref: EC:1.12.7.2 +xref: MetaCyc:HYDROG-RXN +xref: UM-BBD_enzymeID:e0418 +is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor + +[Term] +id: GO:0008902 +name: hydroxymethylpyrimidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-hydroxymethylpyrimidine = ADP + 4-amino-2-methyl-5-phosphomethylpyrimidine." [EC:2.7.1.49] +subset: gosubset_prok +synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49] +synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49] +xref: EC:2.7.1.49 +xref: MetaCyc:OHMETPYRKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008903 +name: hydroxypyruvate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22] +subset: gosubset_prok +synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22] +synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22] +xref: EC:5.3.1.22 +xref: MetaCyc:RXN0-305 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008904 +name: aminoglycoside 7''-O-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + 7''-O-phosphoaminoglycoside." [EC:2.7.1.119, GOC:cb, GOC:mah] +subset: gosubset_prok +synonym: "APH(7'') activity" EXACT [EC:2.7.1.119] +synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" NARROW [EC:2.7.1.119] +synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] +synonym: "hygromycin B kinase activity" NARROW [] +synonym: "hygromycin B phosphotransferase activity" NARROW [EC:2.7.1.119] +synonym: "hygromycin-B kinase activity" NARROW [] +xref: EC:2.7.1.119 +xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0008905 +name: mannose-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.7.7.- +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008906 +name: inosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] +subset: gosubset_prok +synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73] +synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73] +synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] +xref: EC:2.7.1.73 +xref: MetaCyc:INOSINEKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008907 +name: integrase activity +namespace: molecular_function +def: "Catalysis of the integration of lambdoid phage DNA during establishment, probably by forming a transient DNA-protein link." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0008908 +name: isochorismatase activity +namespace: molecular_function +def: "Catalysis of the reaction: isochorismate + H2O = 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate." [EC:3.3.2.1] +subset: gosubset_prok +synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] +synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] +synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1] +synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1] +synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1] +xref: EC:3.3.2.1 +xref: MetaCyc:ISOCHORMAT-RXN +is_a: GO:0004463 ! leukotriene-A4 hydrolase activity + +[Term] +id: GO:0008909 +name: isochorismate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.99.6] +comment: Note that this function was formerly EC:5.4.99.6. +subset: gosubset_prok +synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2] +synonym: "isochorismate mutase activity" EXACT [] +synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2] +xref: EC:5.4.4.2 +xref: MetaCyc:ISOCHORSYN-RXN +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0008910 +name: kanamycin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate." [EC:2.7.1.95] +subset: gosubset_prok +synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] +synonym: "APH(3') activity" EXACT [EC:2.7.1.95] +synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] +synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] +synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] +synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95] +xref: EC:2.7.1.95 +xref: MetaCyc:KANAMYCIN-KINASE-RXN +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0008911 +name: lactaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] +subset: gosubset_prok +synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22] +synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22] +synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22] +xref: EC:1.2.1.22 +xref: MetaCyc:LACTALDDEHYDROG-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008912 +name: lactaldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R) (or (S))-propane-1,2-diol + NAD+ = (R) (or (S))-lactaldehyde + NADH + H+." [EC:1.1.1.77] +subset: gosubset_prok +synonym: "(R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] +synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] +synonym: "propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] +synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77] +xref: EC:1.1.1.77 +xref: MetaCyc:LACTALDREDUCT-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008913 +name: lauroyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "lauroyl transferase activity" EXACT [] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0008914 +name: leucyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] +subset: gosubset_prok +synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6] +synonym: "L/F transferase activity" EXACT [EC:2.3.2.6] +synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6] +synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6] +synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6] +synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] +synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] +xref: EC:2.3.2.6 +xref: MetaCyc:LEUCYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0008915 +name: lipid-A-disaccharide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate." [EC:2.4.1.182] +subset: gosubset_prok +synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182] +xref: EC:2.4.1.182 +xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008917 +name: lipopolysaccharide N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56] +subset: gosubset_prok +synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] +synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] +synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] +xref: EC:2.4.1.56 +xref: MetaCyc:2.4.1.56-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008918 +name: lipopolysaccharide 3-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44] +subset: gosubset_prok +synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] +synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] +synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] +synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] +synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] +synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44] +synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] +synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44] +synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] +xref: EC:2.4.1.44 +xref: MetaCyc:2.4.1.44-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0008919 +name: lipopolysaccharide glucosyltransferase I activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58] +subset: gosubset_prok +synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] +synonym: "LPS glucosyltransferase I activity" EXACT [] +synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] +synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] +synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] +synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] +synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] +xref: EC:2.4.1.58 +xref: MetaCyc:2.4.1.58-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0008920 +name: lipopolysaccharide heptosyltransferase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "LPS heptosyltransferase activity" EXACT [] +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0008921 +name: lipopolysaccharide-1,6-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] +synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0008922 +name: long-chain-fatty-acid-[acyl-carrier-protein] ligase activity +namespace: molecular_function +alt_id: GO:0010300 +def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]." [EC:6.2.1.20] +subset: gosubset_prok +synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20] +synonym: "acyl-ACP synthetase activity" EXACT [] +synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] +synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20] +synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20] +synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20] +synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20] +synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] +xref: EC:6.2.1.20 +xref: MetaCyc:ACYLACPSYNTH-RXN +is_a: GO:0015645 ! fatty-acid ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0008923 +name: lysine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine = cadaverine + CO2." [EC:4.1.1.18] +subset: gosubset_prok +synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18] +synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18] +xref: EC:4.1.1.18 +xref: MetaCyc:LYSDECARBOX-RXN +xref: MetaCyc:PWY0-461 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008924 +name: malate dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + acceptor = oxaloacetate + reduced acceptor." [EC:1.1.99.16] +subset: gosubset_prok +synonym: "(S)-malate:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.16] +synonym: "(S)-malate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.16] +synonym: "FAD-dependent malate-vitamin K reductase activity" EXACT [] +synonym: "malate-vitamin K reductase activity" EXACT [] +xref: EC:1.1.99.16 +xref: MetaCyc:MALATE-DEHYDROGENASE-(ACCEPTOR)-RXN +is_a: GO:0016615 ! malate dehydrogenase activity + +[Term] +id: GO:0008925 +name: maltose O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] +subset: gosubset_prok +synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79] +synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79] +xref: EC:2.3.1.79 +xref: MetaCyc:MALTACETYLTRAN-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0008926 +name: mannitol-1-phosphate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] +subset: gosubset_prok +xref: EC:1.1.1.17 +xref: MetaCyc:MANNPDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008927 +name: mannonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.8] +subset: gosubset_prok +synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8] +synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8] +synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8] +synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8] +synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8] +synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8] +synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8] +xref: EC:4.2.1.8 +xref: MetaCyc:MANNONDEHYDRAT-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008928 +name: mannose-1-phosphate guanylyltransferase (GDP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + D-mannose 1-phosphate = phosphate + GDP-mannose." [EC:2.7.7.22] +subset: gosubset_prok +synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22] +synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] +synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22] +synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] +synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] +synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] +synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] +synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22] +synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22] +synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] +xref: EC:2.7.7.22 +xref: MetaCyc:MANNPGUANYLTRANGDP-RXN +is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity + +[Term] +id: GO:0008929 +name: methylglyoxal synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3] +subset: gosubset_prok +synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3] +synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3] +synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3] +xref: EC:4.2.3.3 +xref: MetaCyc:METHGLYSYN-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0008930 +name: methylthioadenosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] +subset: gosubset_prok +synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16] +synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16] +synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16] +synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16] +synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16] +xref: EC:3.2.2.16 +xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008931 +name: murein DD-endopeptidase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008932 +name: lytic endotransglycosylase activity +namespace: molecular_function +def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] +synonym: "murein lytic endotransglycosylase E activity" NARROW [] +xref: EC:2.4.99.- +is_a: GO:0008933 ! lytic transglycosylase activity + +[Term] +id: GO:0008933 +name: lytic transglycosylase activity +namespace: molecular_function +def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424] +subset: gosubset_prok +synonym: "murein transglycosylase B activity" NARROW [] +synonym: "peptidoglycan lytic transglycosylase activity" EXACT [] +xref: EC:3.2.1.- +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0008934 +name: inositol-1(or 4)-monophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] +subset: gosubset_prok +synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] +synonym: "inositol monophosphate phosphatase activity" BROAD [EC:3.1.3.25] +synonym: "inositol phosphatase activity" BROAD [EC:3.1.3.25] +synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25] +synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25] +synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] +synonym: "myo-inositol monophosphatase activity" BROAD [EC:3.1.3.25] +synonym: "myo-inositol-1(or 4)-monophosphatase activity" EXACT [] +synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] +synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25] +synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] +xref: EC:3.1.3.25 +xref: MetaCyc:MYO-INOSITOL-1(OR-4)-MONOPHOSPHATASE-RXN +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0008935 +name: naphthoate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA." [EC:4.1.3.36] +subset: gosubset_prok +synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36] +synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36] +synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36] +synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36] +synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36] +synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36] +xref: EC:4.1.3.36 +xref: MetaCyc:NAPHTHOATE-SYN-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008936 +name: nicotinamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] +subset: gosubset_prok +synonym: "NAMase activity" EXACT [EC:3.5.1.19] +synonym: "namase activity" EXACT [EC:3.5.1.19] +synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19] +synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19] +synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19] +synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19] +synonym: "YNDase activity" EXACT [EC:3.5.1.19] +xref: EC:3.5.1.19 +xref: MetaCyc:NICOTINAMID-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008937 +name: ferredoxin reductase activity +namespace: molecular_function +def: "Catalysis of the reactions: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-] +subset: gosubset_prok +xref: EC:1.18.1.- +is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor + +[Term] +id: GO:0008938 +name: nicotinate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate." [EC:2.1.1.7] +synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7] +synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7] +xref: EC:2.1.1.7 +xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008939 +name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole." [EC:2.4.2.21] +subset: gosubset_prok +synonym: "CobT" RELATED [EC:2.4.2.21] +synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] +synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] +synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] +synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] +synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] +synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] +synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] +xref: EC:2.4.2.21 +xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0008940 +name: nitrate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NO2- (nitrite) + acceptor = NO3- (nitrate) + reduced acceptor." [EC:1.7.99.4] +subset: gosubset_prok +synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4] +synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4] +synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4] +synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] +xref: EC:1.7.99.4 +xref: MetaCyc:NITRATREDUCT-RXN +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0008941 +name: nitric oxide dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 NO3- + NADP+." [EC:1.14.12.17] +subset: gosubset_prok +synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17] +synonym: "NOD activity" EXACT [EC:1.14.12.17] +xref: EC:1.14.12.17 +xref: MetaCyc:1.14.12.17-RXN +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0008942 +name: nitrite reductase [NAD(P)H] activity +namespace: molecular_function +def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = NO2(-) (nitrite) + 3 NAD(P)H + 3 H+." [EC:1.7.1.4] +comment: Note that this function was formerly EC:1.6.6.4. +subset: gosubset_prok +synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4] +synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] +synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] +synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] +synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] +synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4] +synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4] +synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] +xref: EC:1.7.1.4 +xref: MetaCyc:NITRITREDUCT-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0008943 +name: glyceraldehyde-3-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] +comment: Note that the reaction with phosphate as a substrate produces 3-phospho-D-glyceroyl-phosphate. +subset: gosubset_prok +xref: EC:1.2.1.- +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008944 +name: oligopeptidase A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] +xref: EC:3.4.24.70 +xref: MetaCyc:3.4.24.70-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008945 +name: oligopeptidase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] +synonym: "protease II activity" EXACT [EC:3.4.21.83] +xref: EC:3.4.21.83 +xref: MetaCyc:3.4.21.83-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008946 +name: oligonucleotidase activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3] +comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. +subset: gosubset_prok +xref: EC:3.1.13.3 +xref: MetaCyc:3.1.13.3-RXN +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0008947 +name: omptin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +xref: EC:3.4.21.87 +xref: MetaCyc:3.4.21.87-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008948 +name: oxaloacetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:4.1.1.3] +subset: gosubset_prok +synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3] +synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3] +synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3] +synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3] +synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3] +xref: EC:4.1.1.3 +xref: MetaCyc:OXALODECARB-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008949 +name: oxalyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxalyl-CoA = formyl-CoA + CO2." [EC:4.1.1.8] +subset: gosubset_prok +synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8] +synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8] +synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8] +xref: EC:4.1.1.8 +xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008950 +name: p-aminobenzoate synthetase +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. +is_obsolete: true +consider: GO:0008696 +consider: GO:0046820 + +[Term] +id: GO:0008951 +name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity +namespace: molecular_function +synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0008953 +name: penicillin amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] +subset: gosubset_prok +synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11] +synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11] +synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11] +synonym: "novozym 217" RELATED [EC:3.5.1.11] +synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] +synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11] +synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11] +synonym: "semacylase activity" EXACT [EC:3.5.1.11] +xref: EC:3.5.1.11 +xref: MetaCyc:PENICILLIN-AMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008954 +name: peptidoglycan synthetase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0008955 +name: peptidoglycan glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] +subset: gosubset_prok +synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129] +synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] +synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129] +synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129] +synonym: "PG-II activity" EXACT [EC:2.4.1.129] +synonym: "undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] +xref: EC:2.4.1.129 +xref: MetaCyc:PEPTIDOGLYCAN-GLYCOSYLTRANSFERASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0008956 +name: peptidyl-dipeptidase Dcp activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5] +synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5] +xref: EC:3.4.15.5 +xref: MetaCyc:3.4.15.5-RXN +is_obsolete: true +replaced_by: GO:0008235 +replaced_by: GO:0008241 + +[Term] +id: GO:0008957 +name: phenylacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] +subset: gosubset_prok +synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39] +xref: EC:1.2.1.39 +xref: MetaCyc:PHENDEHYD-RXN +xref: UM-BBD_enzymeID:e0119 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008959 +name: phosphate acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] +subset: gosubset_prok +synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8] +synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8] +synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8] +synonym: "PTA" RELATED [EC:2.3.1.8] +xref: EC:2.3.1.8 +xref: MetaCyc:PHOSACETYLTRANS-RXN +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0008960 +name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] +subset: gosubset_prok +synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20] +synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20] +synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] +synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] +xref: EC:2.7.8.20 +xref: MetaCyc:PGLYCEROLTRANSI-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008961 +name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0008962 +name: phosphatidylglycerophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27] +subset: gosubset_prok +synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27] +synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27] +synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27] +synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27] +xref: EC:3.1.3.27 +xref: MetaCyc:PGPPHOSPHA-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008963 +name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] +subset: gosubset_prok +synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] +synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] +synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] +synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] +synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] +synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] +synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] +synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] +synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] +synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] +synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] +synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] +xref: EC:2.7.8.13 +xref: MetaCyc:PHOSNACMURPENTATRANSLYS-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008964 +name: phosphoenolpyruvate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2." [EC:4.1.1.31] +subset: gosubset_prok +synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31] +synonym: "PEPC" RELATED [EC:4.1.1.31] +synonym: "PEPCase activity" EXACT [EC:4.1.1.31] +synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31] +synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31] +synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31] +synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31] +xref: EC:4.1.1.31 +xref: MetaCyc:PEPCARBOX-RXN +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0008965 +name: phosphoenolpyruvate-protein phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] +subset: gosubset_prok +synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] +synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9] +synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9] +synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9] +synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9] +synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9] +synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9] +synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] +xref: EC:2.7.3.9 +xref: MetaCyc:2.7.3.9-RXN +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0008966 +name: phosphoglucosamine mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10] +subset: gosubset_prok +synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] +synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] +xref: EC:5.4.2.10 +xref: MetaCyc:5.4.2.10-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008967 +name: phosphoglycolate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate." [EC:3.1.3.18] +subset: gosubset_prok +synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18] +synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18] +synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18] +synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18] +synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18] +xref: EC:3.1.3.18 +xref: MetaCyc:GPH-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008968 +name: D-sedoheptulose 7-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] +subset: gosubset_prok +synonym: "phosphoheptose isomerase activity" EXACT [] +xref: MetaCyc:RXN0-4301 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008969 +name: phosphohistidine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate." [GOC:mah] +subset: gosubset_prok +xref: EC:3.1.3.- +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008970 +name: phospholipase A1 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] +subset: gosubset_prok +synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [EC:3.1.1.32] +xref: EC:3.1.1.32 +xref: MetaCyc:PHOSPHOLIPASE-A1-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0004620 ! phospholipase activity + +[Term] +id: GO:0008972 +name: phosphomethylpyrimidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] +subset: gosubset_prok +synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7] +synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7] +xref: EC:2.7.4.7 +xref: MetaCyc:PYRIMSYN3-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0008973 +name: phosphopentomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] +subset: gosubset_prok +synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7] +synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] +synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] +synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] +synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] +synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] +synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7] +xref: EC:5.4.2.7 +xref: MetaCyc:PPENTOMUT-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008974 +name: phosphoribulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate." [EC:2.7.1.19] +subset: gosubset_prok +synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19] +synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19] +synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] +synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19] +synonym: "PKK" RELATED [EC:2.7.1.19] +synonym: "PRK" RELATED [EC:2.7.1.19] +synonym: "PRuK" RELATED [EC:2.7.1.19] +synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19] +synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19] +xref: EC:2.7.1.19 +xref: MetaCyc:PHOSPHORIBULOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008975 +name: pitrilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55] +synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55] +synonym: "protease III activity" EXACT [EC:3.4.24.55] +synonym: "protease Pi activity" EXACT [EC:3.4.24.55] +synonym: "proteinase Pi" RELATED [EC:3.4.24.55] +synonym: "PTR" RELATED [EC:3.4.24.55] +xref: EC:3.4.24.55 +xref: MetaCyc:3.4.24.55-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008976 +name: polyphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] +subset: gosubset_prok +synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] +synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] +synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] +xref: EC:2.7.4.1 +xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0008977 +name: prephenate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+." [EC:1.3.1.12] +subset: gosubset_prok +synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12] +synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] +synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12] +xref: EC:1.3.1.12 +xref: MetaCyc:PREPHENATEDEHYDROG-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008978 +name: prepilin peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +xref: EC:3.4.23.43 +xref: MetaCyc:3.4.23.43-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0008979 +name: prophage integrase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0008907 ! integrase activity + +[Term] +id: GO:0008980 +name: propionate kinase activity +namespace: molecular_function +def: "Catalysis of the reactions: (1) ATP + propanoate = ADP + propanoyl phosphate (2) ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.15] +subset: gosubset_prok +synonym: "ATP:propanoate phosphotransferase activity" EXACT [] +synonym: "PduW" RELATED [] +synonym: "propanoate kinase activity" EXACT [] +synonym: "propionate/acetate kinase activity" EXACT [] +synonym: "TdcD" RELATED [] +xref: EC:2.7.2.15 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0008981 +name: protease IV activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008982 +name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +namespace: molecular_function +alt_id: GO:0015455 +alt_id: GO:0015456 +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] +subset: gosubset_prok +synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] +synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] +synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] +synonym: "gene glC proteins" RELATED [EC:2.7.1.69] +synonym: "group translocator activity" RELATED [EC:2.7.1.69] +synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] +synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] +synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] +synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69] +synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69] +synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69] +synonym: "phosphotransfer-driven group translocator" EXACT [] +synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69] +synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] +synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] +synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] +synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69] +synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69] +synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] +synonym: "PTS permease activity" EXACT [EC:2.7.1.69] +synonym: "PTS transporter" RELATED [EC:2.7.1.69] +synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] +synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] +xref: EC:2.7.1.69 +xref: MetaCyc:2.7.1.69-RXN +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0008983 +name: protein-glutamate O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] +subset: gosubset_prok +synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] +synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] +synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] +synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] +synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80] +synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] +synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80] +synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "protein methylase II" RELATED [EC:2.1.1.80] +synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80] +synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80] +xref: EC:2.1.1.80 +xref: MetaCyc:CHER-RXN +xref: RESID:AA0072 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008984 +name: protein-glutamate methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] +subset: gosubset_prok +synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] +synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] +synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] +synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] +synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] +synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] +xref: EC:3.1.1.61 +xref: MetaCyc:MCPMETEST-RXN +xref: RESID:AA0072 +is_a: GO:0051723 ! protein methylesterase activity + +[Term] +id: GO:0008985 +name: pyruvate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] +subset: gosubset_prok +synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.2] +synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.2.2] +synonym: "pyruvic (cytochrome b1) dehydrogenase activity" EXACT [EC:1.2.2.2] +xref: EC:1.2.2.2 +xref: MetaCyc:PYRUVOXID-RXN +is_a: GO:0004738 ! pyruvate dehydrogenase activity +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0008986 +name: pyruvate, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate." [EC:2.7.9.2] +subset: gosubset_prok +synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2] +synonym: "PEP synthase activity" EXACT [] +synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2] +synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2] +synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2] +synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2] +synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2] +synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2] +synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2] +synonym: "water pyruvate dikinase activity" EXACT [] +xref: EC:2.7.9.2 +xref: MetaCyc:PEPSYNTH-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0008987 +name: quinolinate synthetase A activity +namespace: molecular_function +def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] +subset: gosubset_prok +xref: MetaCyc:QUINOLINATE-SYNTHA-RXN +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0008988 +name: rRNA (adenine-N6-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] +subset: gosubset_prok +synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] +synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] +synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48] +synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48] +synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48] +synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48] +synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48] +xref: EC:2.1.1.48 +xref: MetaCyc:RRNA-(ADENINE-N6-)-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0008989 +name: rRNA (guanine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51] +subset: gosubset_prok +synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51] +xref: EC:2.1.1.51 +xref: MetaCyc:RRNA-(GUANINE-N1-)-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0008990 +name: rRNA (guanine-N2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] +subset: gosubset_prok +synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52] +xref: EC:2.1.1.52 +xref: MetaCyc:RRNA-(GUANINE-N2-)-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0008991 +name: serine-type signal peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] +comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. +xref: EC:3.4.21.- +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008992 +name: repressor LexA activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "LexA repressor" RELATED [EC:3.4.21.88] +synonym: "repressor lexA" RELATED [EC:3.4.21.88] +xref: EC:3.4.21.88 +xref: MetaCyc:3.4.21.88-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008993 +name: rhamnulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] +subset: gosubset_prok +synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5] +synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5] +synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5] +synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5] +synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5] +synonym: "RhuK" RELATED [EC:2.7.1.5] +xref: EC:2.7.1.5 +xref: MetaCyc:RHAMNULOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008994 +name: rhamnulose-1-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] +subset: gosubset_prok +synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19] +synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19] +synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19] +synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19] +synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19] +xref: EC:4.1.2.19 +xref: MetaCyc:RHAMNULPALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008995 +name: ribonuclease E activity +namespace: molecular_function +def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] +subset: gosubset_prok +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0008996 +name: ribonuclease G activity +namespace: molecular_function +def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] +subset: gosubset_prok +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0008997 +name: ribonuclease R activity +namespace: molecular_function +def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] +subset: gosubset_prok +xref: EC:3.1.11.- +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0008998 +name: ribonucleoside-triphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] +subset: gosubset_prok +synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] +synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] +synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] +xref: EC:1.17.4.2 +xref: MetaCyc:1.17.4.2-RXN +is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor + +[Term] +id: GO:0008999 +name: ribosomal-protein-alanine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128] +subset: gosubset_prok +synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128] +synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] +xref: EC:2.3.1.128 +xref: MetaCyc:2.3.1.128-RXN +is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity + +[Term] +id: GO:0009000 +name: selenocysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] +subset: gosubset_prok +synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16] +synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] +synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] +xref: EC:4.4.1.16 +xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0009001 +name: serine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine." [EC:2.3.1.30] +subset: gosubset_prok +synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30] +synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30] +synonym: "SATase activity" EXACT [EC:2.3.1.30] +synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30] +synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30] +xref: EC:2.3.1.30 +xref: MetaCyc:SERINE-O-ACETTRAN-RXN +is_a: GO:0016412 ! serine O-acyltransferase activity +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0009002 +name: serine-type D-Ala-D-Ala carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] +subset: gosubset_prok +synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] +synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4] +synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] +synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4] +synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4] +xref: EC:3.4.16.4 +xref: MetaCyc:3.4.16.4-RXN +is_a: GO:0004185 ! serine-type carboxypeptidase activity + +[Term] +id: GO:0009003 +name: signal peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] +comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. +is_obsolete: true +replaced_by: GO:0008233 + +[Term] +id: GO:0009004 +name: signal peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89] +synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89] +synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89] +synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89] +synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89] +synonym: "HOSP" RELATED [EC:3.4.21.89] +synonym: "leader peptidase activity" EXACT [EC:3.4.21.89] +synonym: "leader peptidase I" RELATED [EC:3.4.21.89] +synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89] +synonym: "leader proteinase activity" EXACT [EC:3.4.21.89] +synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89] +synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89] +synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89] +synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89] +synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89] +synonym: "propeptidase activity" EXACT [EC:3.4.21.89] +synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89] +synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89] +synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] +synonym: "signalase activity" EXACT [EC:3.4.21.89] +synonym: "SPase I activity" EXACT [EC:3.4.21.89] +synonym: "SPC" RELATED [EC:3.4.21.89] +xref: EC:3.4.21.89 +xref: MetaCyc:3.4.21.89-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0009005 +name: signal peptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "leader peptidase II" RELATED [EC:3.4.23.36] +synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] +synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36] +synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] +synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] +synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] +synonym: "SPase II activity" EXACT [EC:3.4.23.36] +xref: EC:3.4.23.36 +xref: MetaCyc:3.4.23.36-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0009006 +name: siroheme synthase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents three different molecular functions. +synonym: "sirohaem synthase activity" EXACT [] +is_obsolete: true +consider: GO:0004851 +consider: GO:0019354 +consider: GO:0043115 +consider: GO:0051266 + +[Term] +id: GO:0009007 +name: site-specific DNA-methyltransferase (adenine-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] +subset: gosubset_prok +synonym: "DNA adenine methylase" BROAD [] +synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] +synonym: "modification methylase activity" RELATED [EC:2.1.1.72] +synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] +synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] +xref: EC:2.1.1.72 +xref: MetaCyc:2.1.1.72-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0009008 ! DNA-methyltransferase activity + +[Term] +id: GO:0009008 +name: DNA-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleate methylase activity" EXACT [EC:2.1.1.-] +synonym: "deoxyribonucleate methyltransferase activity" EXACT [EC:2.1.1.-] +synonym: "deoxyribonucleic acid methylase activity" EXACT [EC:2.1.1.-] +synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [EC:2.1.1.-] +synonym: "deoxyribonucleic acid modification methylase activity" RELATED [EC:2.1.1.-] +synonym: "DNA methylase" BROAD [] +synonym: "DNA methyltransferase activity" EXACT [] +synonym: "DNA transmethylase activity" EXACT [EC:2.1.1.-] +synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0009009 +name: site-specific recombinase activity +namespace: molecular_function +def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh] +comment: Consider also annotating to the molecular function term 'double-stranded DNA binding ; GO:0003690'. Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0009010 +name: sorbitol-6-phosphate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] +subset: gosubset_prok +synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] +synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] +synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] +synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140] +synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] +synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140] +synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140] +xref: EC:1.1.1.140 +xref: MetaCyc:SORB6PDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009011 +name: starch synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] +subset: gosubset_prok +synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] +synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] +synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] +synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] +synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] +synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] +synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] +xref: EC:2.4.1.21 +xref: MetaCyc:GLYCOGENSYN-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0009012 +name: aminoglycoside 3''-adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + aminoglycoside = diphosphate + 3''-adenylylaminoglycoside." [EC:2.7.7.47, GOC:cb] +subset: gosubset_prok +synonym: "AAD (3'')" RELATED [EC:2.7.7.47] +synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] +synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] +xref: EC:2.7.7.47 +xref: MetaCyc:STREPTOMYCIN-3''-ADENYLYLTRANSFERASE-RXN +is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity + +[Term] +id: GO:0009013 +name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] +subset: gosubset_prok +synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16] +synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16] +xref: EC:1.2.1.16 +xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN +xref: UM-BBD_enzymeID:e0020 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009014 +name: succinyl-diaminopimelate desuccinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate." [EC:3.5.1.18] +subset: gosubset_prok +synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18] +synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18] +xref: EC:3.5.1.18 +xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0009015 +name: N-succinylarginine dihydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO." [EC:3.5.3.23] +subset: gosubset_prok +synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23] +synonym: "arginine succinylhydrolase activity" EXACT [] +synonym: "AruB" RELATED [] +synonym: "AstB" RELATED [] +synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] +synonym: "N2-succinylarginine dihydrolase activity" EXACT [] +synonym: "SADH" RELATED [] +synonym: "succinylarginine dihydrolase activity" EXACT [] +xref: EC:3.5.3.23 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0009016 +name: succinyldiaminopimelate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate." [EC:2.6.1.17] +subset: gosubset_prok +synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17] +synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17] +synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] +synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17] +xref: EC:2.6.1.17 +xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0009017 +name: succinylglutamate desuccinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-L-glutamate + H2O = succinate + L-glutamate." [EC:3.5.1.96] +subset: gosubset_prok +synonym: "AstE" RELATED [] +synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96] +synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] +synonym: "SGDS" RELATED [] +xref: EC:3.5.1.96 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0009018 +name: sucrose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] +subset: gosubset_prok +synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] +synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7] +synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7] +xref: EC:2.4.1.7 +xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0009019 +name: tRNA (guanine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] +subset: gosubset_prok +synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] +synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] +synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] +xref: EC:2.1.1.31 +xref: MetaCyc:TRNA-(GUANINE-N1-)-METHYLTRANSFERASE-RXN +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0009020 +name: tRNA (guanosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34] +subset: gosubset_prok +synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] +synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] +xref: EC:2.1.1.34 +xref: MetaCyc:2.1.1.34-RXN +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0009021 +name: tRNA (uracil-5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine." [EC:2.1.1.35] +subset: gosubset_prok +synonym: "m5U-methyltransferase activity" EXACT [EC:2.1.1.35] +synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35] +synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] +synonym: "RUMT activity" EXACT [EC:2.1.1.35] +synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35] +synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] +synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35] +synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] +synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] +synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] +xref: EC:2.1.1.35 +xref: MetaCyc:TRNA-(URACIL-5-)-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity + +[Term] +id: GO:0009022 +name: tRNA nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] +comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. +subset: gosubset_prok +synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] +synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56] +synonym: "RNase PH activity" EXACT [EC:2.7.7.56] +synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] +xref: EC:2.7.7.56 +xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0009023 +name: tRNA sulfurtransferase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators] +synonym: "tRNA sulphurtransferase activity" EXACT [] +is_obsolete: true +consider: GO:0016227 + +[Term] +id: GO:0009024 +name: tagatose-6-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] +subset: gosubset_prok +synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144] +synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144] +xref: EC:2.7.1.144 +xref: MetaCyc:TAGAKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0009025 +name: tagatose-bisphosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.40] +subset: gosubset_prok +synonym: "AgaY" RELATED [] +synonym: "AgaZ" RELATED [] +synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40] +synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40] +synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] +synonym: "D-tagatose-1xxx,6-bisphosphate triosephosphate lyase activity" EXACT [EC:4.1.2.40] +synonym: "KbaY" RELATED [] +synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40] +synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] +xref: EC:4.1.2.40 +xref: MetaCyc:TAGAALDOL-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0009026 +name: tagaturonate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + NADH + H+." [EC:1.1.1.58] +subset: gosubset_prok +synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58] +synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58] +synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58] +synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58] +synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58] +synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58] +synonym: "TagUAR" RELATED [EC:1.1.1.58] +xref: EC:1.1.1.58 +xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009027 +name: tartrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] +subset: gosubset_prok +synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] +synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] +xref: EC:1.1.1.93 +xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009028 +name: tartronate-semialdehyde synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glyoxylate = tartronate semialdehyde + CO2." [EC:4.1.1.47] +subset: gosubset_prok +synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47] +synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47] +synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47] +synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47] +synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47] +synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47] +synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] +synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] +synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] +xref: EC:4.1.1.47 +xref: MetaCyc:GLYOCARBOLIG-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0009029 +name: tetraacyldisaccharide 4'-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate." [EC:2.7.1.130] +subset: gosubset_prok +synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130] +synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] +xref: EC:2.7.1.130 +xref: MetaCyc:TETRAACYLDISACC4KIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0009030 +name: thiamin phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamin phosphate = ADP + thiamin diphosphate." [EC:2.7.4.16] +subset: gosubset_prok +synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16] +synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16] +synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16] +synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16] +synonym: "thiamin-phosphate kinase activity" EXACT [] +synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16] +synonym: "thiamine-phosphate kinase activity" EXACT [] +xref: EC:2.7.4.16 +xref: MetaCyc:THI-P-KIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0009032 +name: thymidine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4] +subset: gosubset_prok +synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4] +synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4] +synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4] +synonym: "gliostatins" RELATED [EC:2.4.2.4] +synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4] +synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] +synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4] +synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] +synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] +xref: EC:2.4.2.4 +xref: MetaCyc:THYM-PHOSPH-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0009033 +name: trimethylamine-N-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9] +subset: gosubset_prok +synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9] +synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9] +synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9] +synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9] +xref: EC:1.6.6.9 +xref: MetaCyc:TMAOREDUCT-RXN +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0009034 +name: tryptophanase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + H2O = indole + pyruvate + NH3." [EC:4.1.99.1] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +subset: gosubset_prok +synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1] +synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1] +synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1] +synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1] +synonym: "TNase activity" EXACT [EC:4.1.99.1] +synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] +synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] +xref: EC:4.1.99.1 +xref: MetaCyc:TRYPDEG-PWY +xref: MetaCyc:TRYPTOPHAN-RXN +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0009035 +name: Type I site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748] +subset: gosubset_prok +synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3] +synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3] +synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3] +synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3] +synonym: "Type I restriction enzyme activity" EXACT [] +synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3] +xref: EC:3.1.21.3 +xref: MetaCyc:3.1.21.3-RXN +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0009036 +name: Type II site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] +subset: gosubset_prok +synonym: "Type II restriction enzyme activity" EXACT [] +xref: EC:3.1.21.4 +xref: MetaCyc:3.1.21.4-RXN +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0009037 +name: tyrosine-based site-specific recombinase activity +namespace: molecular_function +def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] +subset: gosubset_prok +synonym: "site-specific tyrosine recombinase activity" EXACT [] +synonym: "tyrosine recombinase" BROAD [] +is_a: GO:0008907 ! integrase activity +is_a: GO:0009009 ! site-specific recombinase activity + +[Term] +id: GO:0009038 +name: undecaprenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66] +subset: gosubset_prok +synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66] +synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] +synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] +synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66] +synonym: "isoprenoid alcohol kinase (phosphorylating)" EXACT [EC:2.7.1.66] +synonym: "isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] +synonym: "isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] +synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] +synonym: "polyisoprenol kinase activity" EXACT [EC:2.7.1.66] +xref: EC:2.7.1.66 +xref: MetaCyc:UNDECAPRENOL-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0009039 +name: urease activity +namespace: molecular_function +def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] +subset: gosubset_prok +synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] +xref: EC:3.5.1.5 +xref: MetaCyc:UREASE-RXN +xref: UM-BBD_enzymeID:e0170 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0009040 +name: ureidoglycolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-ureidoglycolate + NADP+ = oxalureate + NADPH + H+." [EC:1.1.1.154] +subset: gosubset_prok +synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154] +xref: EC:1.1.1.154 +xref: MetaCyc:R165-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009041 +name: uridylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] +subset: gosubset_prok +xref: EC:2.7.4.- +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019201 ! nucleotide kinase activity + +[Term] +id: GO:0009042 +name: valine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66] +subset: gosubset_prok +synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66] +synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66] +synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] +synonym: "transaminase C activity" NARROW [EC:2.6.1.66] +synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] +synonym: "valine-pyruvate aminotransferase activity" EXACT [] +xref: EC:2.6.1.66 +xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0009044 +name: xylan 1,4-beta-xylosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] +subset: gosubset_prok +synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37] +synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37] +synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37] +synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37] +synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37] +synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37] +synonym: "xylobiase activity" EXACT [EC:3.2.1.37] +xref: EC:3.2.1.37 +xref: MetaCyc:3.2.1.37-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0009045 +name: xylose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] +subset: gosubset_prok +synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5] +synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5] +synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5] +synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5] +xref: EC:5.3.1.5 +xref: MetaCyc:XYLISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0009046 +name: zinc D-Ala-D-Ala carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] +synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14] +synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14] +synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] +synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14] +synonym: "G enzyme" RELATED [EC:3.4.17.14] +synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] +synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14] +xref: EC:3.4.17.14 +xref: MetaCyc:3.4.17.14-RXN +is_a: GO:0004181 ! metallocarboxypeptidase activity + +[Term] +id: GO:0009047 +name: dosage compensation, by hyperactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome." [GOC:jl, ISBN:0140512888, PMID:11498577] +synonym: "dosage compensation (sensu Insecta)" EXACT [] +is_a: GO:0007549 ! dosage compensation + +[Term] +id: GO:0009048 +name: dosage compensation, by inactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, ISBN:0140512888, PMID:11498577] +synonym: "chromosome inactivation" BROAD [] +synonym: "X chromosome inactivation" EXACT [] +is_a: GO:0007549 ! dosage compensation + +[Term] +id: GO:0009049 +name: aspartic-type signal peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] +comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. +subset: gosubset_prok +xref: EC:3.4.23.- +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0009050 +name: glycopeptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycopeptide breakdown" EXACT [] +synonym: "glycopeptide catabolism" EXACT [] +synonym: "glycopeptide degradation" EXACT [] +is_a: GO:0006516 ! glycoprotein catabolic process + +[Term] +id: GO:0009051 +name: pentose-phosphate shunt, oxidative branch +namespace: biological_process +def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:OXIDATIVEPENT-PWY] +subset: gosubset_prok +synonym: "oxidative branch, pentose pathway" EXACT [] +synonym: "oxidative pentose phosphate pathway" EXACT [] +synonym: "pentose phosphate pathway, oxidative branch" EXACT [] +synonym: "pentose phosphate shunt, oxidative branch" EXACT [] +synonym: "pentose-phosphate pathway, oxidative branch" EXACT [] +xref: MetaCyc:OXIDATIVEPENT-PWY +is_a: GO:0019321 ! pentose metabolic process +relationship: part_of GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:0009052 +name: pentose-phosphate shunt, non-oxidative branch +namespace: biological_process +def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:NONOXIPENT-PWY] +subset: gosubset_prok +synonym: "pentose phosphate pathway, non-oxidative branch" EXACT [] +synonym: "pentose phosphate shunt, non-oxidative branch" EXACT [] +synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT [] +xref: MetaCyc:NONOXIPENT-PWY +xref: MetaCyc:P21-PWY +is_a: GO:0019321 ! pentose metabolic process +relationship: part_of GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:0009055 +name: electron carrier activity +namespace: molecular_function +alt_id: GO:0009053 +alt_id: GO:0009054 +def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "2Fe-2S electron transfer carrier" NARROW [] +synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW [] +synonym: "adrenodoxin-type ferredoxin" NARROW [] +synonym: "amicyanin" NARROW [] +synonym: "azurin" NARROW [] +synonym: "bacterial-type ferredoxin" NARROW [] +synonym: "chloroplast-type ferredoxin" NARROW [] +synonym: "copper electron carrier" NARROW [] +synonym: "dicluster bacterial-type ferredoxin" NARROW [] +synonym: "electron acceptor activity" NARROW [] +synonym: "electron carrier, chlorophyll electron transport system" RELATED [] +synonym: "electron donor activity" NARROW [] +synonym: "electron transfer flavoprotein" NARROW [] +synonym: "electron transfer flavoprotein, group I" NARROW [] +synonym: "electron transfer flavoprotein, group II" NARROW [] +synonym: "electron transporter activity" EXACT [] +synonym: "high-potential iron-sulfur carrier" NARROW [] +synonym: "iron-sulfur electron transfer carrier" NARROW [] +synonym: "monocluster bacterial-type ferredoxin" NARROW [] +synonym: "mononuclear iron electron carrier" NARROW [] +synonym: "polyferredoxin" NARROW [] +synonym: "redox-active disulfide bond electron carrier" NARROW [] +synonym: "rubredoxin" NARROW [] +synonym: "small blue copper electron carrier" NARROW [] +synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW [] +xref: Reactome:20046 +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0009056 +name: catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +synonym: "breakdown" EXACT [] +synonym: "catabolism" EXACT [] +synonym: "degradation" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0009057 +name: macromolecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33839, GOC:mah] +subset: gosubset_prok +synonym: "macromolecule breakdown" EXACT [] +synonym: "macromolecule catabolism" EXACT [] +synonym: "macromolecule degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0009058 +name: biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +synonym: "anabolism" EXACT [] +synonym: "biosynthesis" EXACT [] +synonym: "formation" EXACT [] +synonym: "synthesis" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0009059 +name: macromolecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33839, GOC:mah] +subset: gosubset_prok +synonym: "macromolecule anabolism" EXACT [] +synonym: "macromolecule biosynthesis" EXACT [] +synonym: "macromolecule formation" EXACT [] +synonym: "macromolecule synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0009060 +name: aerobic respiration +namespace: biological_process +def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:jl, ISBN:0140513590] +subset: gosubset_prok +xref: MetaCyc:AERESPDON-PWY +xref: MetaCyc:PWY-3781 +is_a: GO:0045333 ! cellular respiration + +[Term] +id: GO:0009061 +name: anaerobic respiration +namespace: biological_process +def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:jl, ISBN:0140513590] +subset: gosubset_prok +xref: MetaCyc:ANARESP1-PWY +xref: MetaCyc:ANARESPACC-PWY +xref: MetaCyc:ANARESPDON-PWY +is_a: GO:0045333 ! cellular respiration + +[Term] +id: GO:0009062 +name: fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] +subset: gosubset_prok +synonym: "fatty acid breakdown" EXACT [] +synonym: "fatty acid catabolism" EXACT [] +synonym: "fatty acid degradation" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0009063 +name: amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] +subset: gosubset_prok +synonym: "amino acid breakdown" EXACT [] +synonym: "amino acid catabolism" EXACT [] +synonym: "amino acid degradation" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process +is_a: GO:0009310 ! amine catabolic process + +[Term] +id: GO:0009064 +name: glutamine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +subset: gosubset_prok +synonym: "glutamine family amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0009065 +name: glutamine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +subset: gosubset_prok +synonym: "glutamine family amino acid breakdown" EXACT [] +synonym: "glutamine family amino acid catabolism" EXACT [] +synonym: "glutamine family amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0009066 +name: aspartate family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] +subset: gosubset_prok +synonym: "aspartate family amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0009067 +name: aspartate family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] +subset: gosubset_prok +synonym: "aspartate family amino acid anabolism" EXACT [] +synonym: "aspartate family amino acid biosynthesis" EXACT [] +synonym: "aspartate family amino acid formation" EXACT [] +synonym: "aspartate family amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0009068 +name: aspartate family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] +subset: gosubset_prok +synonym: "aspartate family amino acid breakdown" EXACT [] +synonym: "aspartate family amino acid catabolism" EXACT [] +synonym: "aspartate family amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0009069 +name: serine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] +subset: gosubset_prok +synonym: "serine family amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0009070 +name: serine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] +subset: gosubset_prok +synonym: "serine family amino acid anabolism" EXACT [] +synonym: "serine family amino acid biosynthesis" EXACT [] +synonym: "serine family amino acid formation" EXACT [] +synonym: "serine family amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0009071 +name: serine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] +subset: gosubset_prok +synonym: "serine family amino acid breakdown" EXACT [] +synonym: "serine family amino acid catabolism" EXACT [] +synonym: "serine family amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0009072 +name: aromatic amino acid family metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] +subset: gosubset_prok +synonym: "aromatic amino acid family metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process + +[Term] +id: GO:0009073 +name: aromatic amino acid family biosynthetic process +namespace: biological_process +alt_id: GO:0016089 +def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] +subset: gosubset_prok +synonym: "aromatic amino acid family anabolism" EXACT [] +synonym: "aromatic amino acid family biosynthesis" EXACT [] +synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] +synonym: "aromatic amino acid family formation" EXACT [] +synonym: "aromatic amino acid family synthesis" EXACT [] +xref: MetaCyc:COMPLETE-ARO-PWY +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0009074 +name: aromatic amino acid family catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] +subset: gosubset_prok +synonym: "aromatic amino acid family breakdown" EXACT [] +synonym: "aromatic amino acid family catabolism" EXACT [] +synonym: "aromatic amino acid family degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0009075 +name: histidine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai] +subset: gosubset_prok +synonym: "histidine family amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0009076 +name: histidine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai] +subset: gosubset_prok +synonym: "histidine family amino acid anabolism" EXACT [] +synonym: "histidine family amino acid biosynthesis" EXACT [] +synonym: "histidine family amino acid formation" EXACT [] +synonym: "histidine family amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009075 ! histidine family amino acid metabolic process + +[Term] +id: GO:0009077 +name: histidine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai] +subset: gosubset_prok +synonym: "histidine family amino acid breakdown" EXACT [] +synonym: "histidine family amino acid catabolism" EXACT [] +synonym: "histidine family amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009075 ! histidine family amino acid metabolic process + +[Term] +id: GO:0009078 +name: pyruvate family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] +subset: gosubset_prok +synonym: "pyruvate family amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0009079 +name: pyruvate family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] +subset: gosubset_prok +synonym: "pyruvate family amino acid anabolism" EXACT [] +synonym: "pyruvate family amino acid biosynthesis" EXACT [] +synonym: "pyruvate family amino acid formation" EXACT [] +synonym: "pyruvate family amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009078 ! pyruvate family amino acid metabolic process + +[Term] +id: GO:0009080 +name: pyruvate family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] +subset: gosubset_prok +synonym: "pyruvate family amino acid breakdown" EXACT [] +synonym: "pyruvate family amino acid catabolism" EXACT [] +synonym: "pyruvate family amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009078 ! pyruvate family amino acid metabolic process + +[Term] +id: GO:0009081 +name: branched chain family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] +subset: gosubset_prok +synonym: "branched chain family amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0009082 +name: branched chain family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] +subset: gosubset_prok +synonym: "branched chain family amino acid anabolism" EXACT [] +synonym: "branched chain family amino acid biosynthesis" EXACT [] +synonym: "branched chain family amino acid formation" EXACT [] +synonym: "branched chain family amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009081 ! branched chain family amino acid metabolic process + +[Term] +id: GO:0009083 +name: branched chain family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] +subset: gosubset_prok +synonym: "branched chain family amino acid breakdown" EXACT [] +synonym: "branched chain family amino acid catabolism" EXACT [] +synonym: "branched chain family amino acid degradation" EXACT [] +xref: Reactome:211987 +xref: Reactome:221751 +xref: Reactome:230332 +xref: Reactome:238369 +xref: Reactome:244924 +xref: Reactome:249812 +xref: Reactome:252552 +xref: Reactome:255729 +xref: Reactome:259122 +xref: Reactome:262480 +xref: Reactome:265311 +xref: Reactome:268441 +xref: Reactome:274154 +xref: Reactome:280627 +xref: Reactome:286646 +xref: Reactome:288331 +xref: Reactome:289848 +xref: Reactome:290399 +xref: Reactome:291769 +xref: Reactome:292423 +xref: Reactome:293745 +xref: Reactome:70895 +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0009081 ! branched chain family amino acid metabolic process + +[Term] +id: GO:0009084 +name: glutamine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +subset: gosubset_prok +synonym: "glutamine family amino acid anabolism" EXACT [] +synonym: "glutamine family amino acid biosynthesis" EXACT [] +synonym: "glutamine family amino acid formation" EXACT [] +synonym: "glutamine family amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0009085 +name: lysine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "lysine anabolism" EXACT [] +synonym: "lysine biosynthesis" EXACT [] +synonym: "lysine formation" EXACT [] +synonym: "lysine synthesis" EXACT [] +xref: MetaCyc:ASPLYSANA-PWY +xref: MetaCyc:PWY-5097 +is_a: GO:0006553 ! lysine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0009086 +name: methionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methionine anabolism" EXACT [] +synonym: "methionine biosynthesis" EXACT [] +synonym: "methionine formation" EXACT [] +synonym: "methionine synthesis" EXACT [] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0006555 ! methionine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0009087 +name: methionine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methionine breakdown" EXACT [] +synonym: "methionine catabolism" EXACT [] +synonym: "methionine degradation" EXACT [] +xref: UM-BBD_pathwayID:met +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0006555 ! methionine metabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0009088 +name: threonine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "threonine anabolism" EXACT [] +synonym: "threonine biosynthesis" EXACT [] +synonym: "threonine formation" EXACT [] +synonym: "threonine synthesis" EXACT [] +xref: MetaCyc:HOMOSER-THRESYN-PWY +xref: MetaCyc:THRESYN-PWY +is_a: GO:0006566 ! threonine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0009089 +name: lysine biosynthetic process via diaminopimelate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] +subset: gosubset_prok +synonym: "diaminopimelate pathway" EXACT [] +synonym: "diaminopimelic acid pathway" EXACT [] +synonym: "lysine anabolism via diaminopimelate" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid" EXACT [] +synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT [] +synonym: "lysine formation via diaminopimelate" EXACT [] +synonym: "lysine synthesis via diaminopimelate" EXACT [] +is_a: GO:0009085 ! lysine biosynthetic process +is_a: GO:0046451 ! diaminopimelate metabolic process + +[Term] +id: GO:0009090 +name: homoserine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "homoserine anabolism" EXACT [] +synonym: "homoserine biosynthesis" EXACT [] +synonym: "homoserine formation" EXACT [] +synonym: "homoserine synthesis" EXACT [] +xref: MetaCyc:HOMOSERSYN-PWY +is_a: GO:0009070 ! serine family amino acid biosynthetic process +is_a: GO:0009092 ! homoserine metabolic process + +[Term] +id: GO:0009091 +name: homoserine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "homoserine breakdown" EXACT [] +synonym: "homoserine catabolism" EXACT [] +synonym: "homoserine degradation" EXACT [] +xref: MetaCyc:HOMCAT-PWY +xref: MetaCyc:HOMOCYSDEGR-PWY +is_a: GO:0009071 ! serine family amino acid catabolic process +is_a: GO:0009092 ! homoserine metabolic process + +[Term] +id: GO:0009092 +name: homoserine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "homoserine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0009093 +name: cysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "cysteine breakdown" EXACT [] +synonym: "cysteine catabolism" EXACT [] +synonym: "cysteine degradation" EXACT [] +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process + +[Term] +id: GO:0009094 +name: L-phenylalanine biosynthetic process +namespace: biological_process +alt_id: GO:0019274 +alt_id: GO:0019275 +def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the levorotatory isomer of 2-amino-3-phenylpropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-phenylalanine anabolism" EXACT [] +synonym: "L-phenylalanine biosynthesis" EXACT [] +synonym: "L-phenylalanine formation" EXACT [] +synonym: "L-phenylalanine synthesis" EXACT [] +synonym: "phenylalanine biosynthesis" BROAD [] +synonym: "phenylalanine biosynthetic process" BROAD [] +synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED [] +synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED [] +is_a: GO:0006558 ! L-phenylalanine metabolic process +is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway + +[Term] +id: GO:0009095 +name: aromatic amino acid family biosynthetic process, prephenate pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways"] +subset: gosubset_prok +synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT [] +synonym: "aromatic amino acid family formation, prephenate pathway" EXACT [] +synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT [] +xref: MetaCyc:PHETYRSYN-PWY +is_a: GO:0009073 ! aromatic amino acid family biosynthetic process + +[Term] +id: GO:0009097 +name: isoleucine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "isoleucine anabolism" EXACT [] +synonym: "isoleucine biosynthesis" EXACT [] +synonym: "isoleucine formation" EXACT [] +synonym: "isoleucine synthesis" EXACT [] +xref: MetaCyc:ILEUSYN-PWY +is_a: GO:0006549 ! isoleucine metabolic process +is_a: GO:0009082 ! branched chain family amino acid biosynthetic process + +[Term] +id: GO:0009098 +name: leucine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "leucine anabolism" EXACT [] +synonym: "leucine biosynthesis" EXACT [] +synonym: "leucine formation" EXACT [] +synonym: "leucine synthesis" EXACT [] +xref: MetaCyc:LEUSYN-PWY +is_a: GO:0006551 ! leucine metabolic process +is_a: GO:0009082 ! branched chain family amino acid biosynthetic process + +[Term] +id: GO:0009099 +name: valine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "valine anabolism" EXACT [] +synonym: "valine biosynthesis" EXACT [] +synonym: "valine formation" EXACT [] +synonym: "valine synthesis" EXACT [] +xref: MetaCyc:VALSYN-PWY +is_a: GO:0006573 ! valine metabolic process +is_a: GO:0009082 ! branched chain family amino acid biosynthetic process + +[Term] +id: GO:0009100 +name: glycoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycoprotein metabolism" EXACT [] +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0009101 +name: glycoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycoprotein anabolism" EXACT [] +synonym: "glycoprotein biosynthesis" EXACT [] +synonym: "glycoprotein formation" EXACT [] +synonym: "glycoprotein synthesis" EXACT [] +xref: Reactome:162699 +xref: Reactome:259000 +xref: Reactome:262370 +xref: Reactome:274040 +xref: Reactome:286540 +is_a: GO:0009100 ! glycoprotein metabolic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process + +[Term] +id: GO:0009102 +name: biotin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "biotin anabolism" EXACT [] +synonym: "biotin biosynthesis" EXACT [] +synonym: "biotin formation" EXACT [] +synonym: "biotin synthesis" EXACT [] +synonym: "vitamin B7 biosynthesis" EXACT [] +synonym: "vitamin B7 biosynthetic process" EXACT [] +synonym: "vitamin H biosynthesis" EXACT [] +synonym: "vitamin H biosynthetic process" EXACT [] +xref: MetaCyc:BIOTIN-SYNTHESIS-PWY +xref: MetaCyc:PWY-3701 +is_a: GO:0006768 ! biotin metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0009103 +name: lipopolysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] +subset: gosubset_prok +synonym: "lipopolysaccharide anabolism" EXACT [] +synonym: "lipopolysaccharide biosynthesis" EXACT [] +synonym: "lipopolysaccharide formation" EXACT [] +synonym: "lipopolysaccharide synthesis" EXACT [] +synonym: "LPS biosynthetic process" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0008653 ! lipopolysaccharide metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0009104 +name: lipopolysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] +subset: gosubset_prok +synonym: "lipopolysaccharide breakdown" EXACT [] +synonym: "lipopolysaccharide catabolism" EXACT [] +synonym: "lipopolysaccharide degradation" EXACT [] +synonym: "LPS catabolic process" EXACT [] +is_a: GO:0008653 ! lipopolysaccharide metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0009105 +name: lipoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "lipoic acid anabolism" EXACT [] +synonym: "lipoic acid biosynthesis" EXACT [] +synonym: "lipoic acid formation" EXACT [] +synonym: "lipoic acid synthesis" EXACT [] +is_a: GO:0000273 ! lipoic acid metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process + +[Term] +id: GO:0009106 +name: lipoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipoate metabolism" EXACT [] +is_a: GO:0000273 ! lipoic acid metabolic process + +[Term] +id: GO:0009107 +name: lipoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipoate anabolism" EXACT [] +synonym: "lipoate biosynthesis" EXACT [] +synonym: "lipoate formation" EXACT [] +synonym: "lipoate synthesis" EXACT [] +is_a: GO:0009105 ! lipoic acid biosynthetic process +is_a: GO:0009106 ! lipoate metabolic process + +[Term] +id: GO:0009108 +name: coenzyme biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +subset: gosubset_prok +synonym: "coenzyme anabolism" EXACT [] +synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] +synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] +synonym: "coenzyme biosynthesis" EXACT [] +synonym: "coenzyme formation" EXACT [] +synonym: "coenzyme synthesis" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0051188 ! cofactor biosynthetic process + +[Term] +id: GO:0009109 +name: coenzyme catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +subset: gosubset_prok +synonym: "coenzyme and prosthetic group catabolic process" BROAD [] +synonym: "coenzyme and prosthetic group catabolism" BROAD [] +synonym: "coenzyme breakdown" EXACT [] +synonym: "coenzyme catabolism" EXACT [] +synonym: "coenzyme degradation" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0051187 ! cofactor catabolic process + +[Term] +id: GO:0009110 +name: vitamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "vitamin anabolism" EXACT [] +synonym: "vitamin biosynthesis" EXACT [] +synonym: "vitamin formation" EXACT [] +synonym: "vitamin synthesis" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0009111 +name: vitamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin breakdown" EXACT [] +synonym: "vitamin catabolism" EXACT [] +synonym: "vitamin degradation" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0009112 +name: nucleobase metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] +subset: gosubset_prok +synonym: "nucleobase metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process + +[Term] +id: GO:0009113 +name: purine base biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine base anabolism" EXACT [] +synonym: "purine base biosynthesis" EXACT [] +synonym: "purine base formation" EXACT [] +synonym: "purine base synthesis" EXACT [] +xref: MetaCyc:PURSYN-PWY +xref: MetaCyc:PWY-841 +is_a: GO:0006144 ! purine base metabolic process +is_a: GO:0046112 ! nucleobase biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0009114 +name: hypoxanthine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] +subset: gosubset_prok +synonym: "hypoxanthine breakdown" EXACT [] +synonym: "hypoxanthine catabolism" EXACT [] +synonym: "hypoxanthine degradation" EXACT [] +is_a: GO:0006145 ! purine base catabolic process +is_a: GO:0046100 ! hypoxanthine metabolic process + +[Term] +id: GO:0009115 +name: xanthine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "xanthine breakdown" EXACT [] +synonym: "xanthine catabolism" EXACT [] +synonym: "xanthine degradation" EXACT [] +is_a: GO:0006145 ! purine base catabolic process +is_a: GO:0046110 ! xanthine metabolic process + +[Term] +id: GO:0009116 +name: nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] +subset: goslim_pir +subset: gosubset_prok +synonym: "nucleoside metabolism" EXACT [] +is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process + +[Term] +id: GO:0009117 +name: nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] +subset: goslim_pir +subset: gosubset_prok +synonym: "nucleotide metabolism" EXACT [] +xref: MetaCyc:NUCMET2-PWY +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0009118 +name: regulation of nucleoside metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of nucleoside metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: regulates GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0009119 +name: ribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "ribonucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0009120 +name: deoxyribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +subset: gosubset_prok +synonym: "deoxyribonucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0009123 +name: nucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009124 +name: nucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside monophosphate anabolism" EXACT [] +synonym: "nucleoside monophosphate biosynthesis" EXACT [] +synonym: "nucleoside monophosphate formation" EXACT [] +synonym: "nucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0009125 +name: nucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside monophosphate breakdown" EXACT [] +synonym: "nucleoside monophosphate catabolism" EXACT [] +synonym: "nucleoside monophosphate degradation" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0009126 +name: purine nucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside monophosphate metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009123 ! nucleoside monophosphate metabolic process + +[Term] +id: GO:0009127 +name: purine nucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside monophosphate anabolism" EXACT [] +synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] +synonym: "purine nucleoside monophosphate formation" EXACT [] +synonym: "purine nucleoside monophosphate synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009128 +name: purine nucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside monophosphate breakdown" EXACT [] +synonym: "purine nucleoside monophosphate catabolism" EXACT [] +synonym: "purine nucleoside monophosphate degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009129 +name: pyrimidine nucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009123 ! nucleoside monophosphate metabolic process + +[Term] +id: GO:0009130 +name: pyrimidine nucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT [] +synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside monophosphate formation" EXACT [] +synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT [] +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009131 +name: pyrimidine nucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT [] +synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT [] +synonym: "pyrimidine nucleoside monophosphate degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009132 +name: nucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009133 +name: nucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside diphosphate anabolism" EXACT [] +synonym: "nucleoside diphosphate biosynthesis" EXACT [] +synonym: "nucleoside diphosphate formation" EXACT [] +synonym: "nucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0009134 +name: nucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside diphosphate breakdown" EXACT [] +synonym: "nucleoside diphosphate catabolism" EXACT [] +synonym: "nucleoside diphosphate degradation" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0009135 +name: purine nucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside diphosphate metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009132 ! nucleoside diphosphate metabolic process + +[Term] +id: GO:0009136 +name: purine nucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside diphosphate anabolism" EXACT [] +synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside diphosphate formation" EXACT [] +synonym: "purine nucleoside diphosphate synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009137 +name: purine nucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside diphosphate breakdown" EXACT [] +synonym: "purine nucleoside diphosphate catabolism" EXACT [] +synonym: "purine nucleoside diphosphate degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009138 +name: pyrimidine nucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009132 ! nucleoside diphosphate metabolic process + +[Term] +id: GO:0009139 +name: pyrimidine nucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT [] +synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside diphosphate formation" EXACT [] +synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT [] +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009140 +name: pyrimidine nucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT [] +synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT [] +synonym: "pyrimidine nucleoside diphosphate degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009141 +name: nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009142 +name: nucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside triphosphate anabolism" EXACT [] +synonym: "nucleoside triphosphate biosynthesis" EXACT [] +synonym: "nucleoside triphosphate formation" EXACT [] +synonym: "nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0009143 +name: nucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleoside triphosphate breakdown" EXACT [] +synonym: "nucleoside triphosphate catabolism" EXACT [] +synonym: "nucleoside triphosphate degradation" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0009144 +name: purine nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009145 +name: purine nucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside triphosphate anabolism" EXACT [] +synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside triphosphate formation" EXACT [] +synonym: "purine nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009146 +name: purine nucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine nucleoside triphosphate breakdown" EXACT [] +synonym: "purine nucleoside triphosphate catabolism" EXACT [] +synonym: "purine nucleoside triphosphate degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009147 +name: pyrimidine nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009148 +name: pyrimidine nucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] +synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] +synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009149 +name: pyrimidine nucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT [] +synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT [] +synonym: "pyrimidine nucleoside triphosphate degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009150 +name: purine ribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleotide metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009151 +name: purine deoxyribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009152 +name: purine ribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleotide anabolism" EXACT [] +synonym: "purine ribonucleotide biosynthesis" EXACT [] +synonym: "purine ribonucleotide formation" EXACT [] +synonym: "purine ribonucleotide synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009153 +name: purine deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleotide anabolism" EXACT [] +synonym: "purine deoxyribonucleotide biosynthesis" EXACT [] +synonym: "purine deoxyribonucleotide formation" EXACT [] +synonym: "purine deoxyribonucleotide synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009154 +name: purine ribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleotide breakdown" EXACT [] +synonym: "purine ribonucleotide catabolism" EXACT [] +synonym: "purine ribonucleotide degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009155 +name: purine deoxyribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleotide breakdown" EXACT [] +synonym: "purine deoxyribonucleotide catabolism" EXACT [] +synonym: "purine deoxyribonucleotide degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process + +[Term] +id: GO:0009156 +name: ribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside monophosphate anabolism" EXACT [] +synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "ribonucleoside monophosphate formation" EXACT [] +synonym: "ribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009157 +name: deoxyribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside monophosphate anabolism" EXACT [] +synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "deoxyribonucleoside monophosphate formation" EXACT [] +synonym: "deoxyribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009158 +name: ribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside monophosphate breakdown" EXACT [] +synonym: "ribonucleoside monophosphate catabolism" EXACT [] +synonym: "ribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009159 +name: deoxyribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside monophosphate breakdown" EXACT [] +synonym: "deoxyribonucleoside monophosphate catabolism" EXACT [] +synonym: "deoxyribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process + +[Term] +id: GO:0009161 +name: ribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009162 +name: deoxyribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009163 +name: nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +subset: gosubset_prok +synonym: "nucleoside anabolism" EXACT [] +synonym: "nucleoside biosynthesis" EXACT [] +synonym: "nucleoside formation" EXACT [] +synonym: "nucleoside synthesis" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process + +[Term] +id: GO:0009164 +name: nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl] +subset: gosubset_prok +synonym: "nucleoside breakdown" EXACT [] +synonym: "nucleoside catabolism" EXACT [] +synonym: "nucleoside degradation" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process + +[Term] +id: GO:0009165 +name: nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] +subset: gosubset_prok +synonym: "nucleotide anabolism" EXACT [] +synonym: "nucleotide biosynthesis" EXACT [] +synonym: "nucleotide formation" EXACT [] +synonym: "nucleotide synthesis" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009166 +name: nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] +subset: gosubset_prok +synonym: "nucleotide breakdown" EXACT [] +synonym: "nucleotide catabolism" EXACT [] +synonym: "nucleotide degradation" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0009167 +name: purine ribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009168 +name: purine ribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] +synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside monophosphate formation" EXACT [] +synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009169 +name: purine ribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside monophosphate breakdown" EXACT [] +synonym: "purine ribonucleoside monophosphate catabolism" EXACT [] +synonym: "purine ribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009170 +name: purine deoxyribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009171 +name: purine deoxyribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate formation" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009172 +name: purine deoxyribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009173 +name: pyrimidine ribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0009174 +name: pyrimidine ribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process + +[Term] +id: GO:0009175 +name: pyrimidine ribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process +is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process + +[Term] +id: GO:0009176 +name: pyrimidine deoxyribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0009177 +name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process +is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009178 +name: pyrimidine deoxyribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process +is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process + +[Term] +id: GO:0009179 +name: purine ribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009180 +name: purine ribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside diphosphate formation" EXACT [] +synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process +is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process + +[Term] +id: GO:0009181 +name: purine ribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] +synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] +synonym: "purine ribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process +is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process + +[Term] +id: GO:0009182 +name: purine deoxyribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009183 +name: purine deoxyribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate formation" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process + +[Term] +id: GO:0009184 +name: purine deoxyribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process + +[Term] +id: GO:0009185 +name: ribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009186 +name: deoxyribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009187 +name: cyclic nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyclic nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009188 +name: ribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside diphosphate anabolism" EXACT [] +synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside diphosphate formation" EXACT [] +synonym: "ribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009189 +name: deoxyribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside diphosphate anabolism" EXACT [] +synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "deoxyribonucleoside diphosphate formation" EXACT [] +synonym: "deoxyribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009190 +name: cyclic nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyclic nucleotide anabolism" EXACT [] +synonym: "cyclic nucleotide biosynthesis" EXACT [] +synonym: "cyclic nucleotide formation" EXACT [] +synonym: "cyclic nucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0009191 +name: ribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside diphosphate breakdown" EXACT [] +synonym: "ribonucleoside diphosphate catabolism" EXACT [] +synonym: "ribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009192 +name: deoxyribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside diphosphate breakdown" EXACT [] +synonym: "deoxyribonucleoside diphosphate catabolism" EXACT [] +synonym: "deoxyribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process + +[Term] +id: GO:0009193 +name: pyrimidine ribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0009194 +name: pyrimidine ribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process +is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process + +[Term] +id: GO:0009195 +name: pyrimidine ribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process +is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process + +[Term] +id: GO:0009196 +name: pyrimidine deoxyribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0009197 +name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process +is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009198 +name: pyrimidine deoxyribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process +is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process + +[Term] +id: GO:0009199 +name: ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009200 +name: deoxyribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009201 +name: ribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside triphosphate anabolism" EXACT [] +synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside triphosphate formation" EXACT [] +synonym: "ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009202 +name: deoxyribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] +synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "deoxyribonucleoside triphosphate formation" EXACT [] +synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009203 +name: ribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleoside triphosphate breakdown" EXACT [] +synonym: "ribonucleoside triphosphate catabolism" EXACT [] +synonym: "ribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009204 +name: deoxyribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleoside triphosphate breakdown" EXACT [] +synonym: "deoxyribonucleoside triphosphate catabolism" EXACT [] +synonym: "deoxyribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process + +[Term] +id: GO:0009205 +name: purine ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009206 +name: purine ribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside triphosphate formation" EXACT [] +synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009207 +name: purine ribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] +synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] +synonym: "purine ribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009208 +name: pyrimidine ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0009209 +name: pyrimidine ribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process + +[Term] +id: GO:0009210 +name: pyrimidine ribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process +is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process + +[Term] +id: GO:0009211 +name: pyrimidine deoxyribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0009212 +name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process +is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009213 +name: pyrimidine deoxyribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process +is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process + +[Term] +id: GO:0009214 +name: cyclic nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyclic nucleotide breakdown" EXACT [] +synonym: "cyclic nucleotide catabolism" EXACT [] +synonym: "cyclic nucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0009215 +name: purine deoxyribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009216 +name: purine deoxyribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate formation" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009217 +name: purine deoxyribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009218 +name: pyrimidine ribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleotide metabolism" EXACT [] +xref: MetaCyc:PYR-RIBONUCMET-PWY +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009219 +name: pyrimidine deoxyribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009220 +name: pyrimidine ribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleotide anabolism" EXACT [] +synonym: "pyrimidine ribonucleotide biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleotide formation" EXACT [] +synonym: "pyrimidine ribonucleotide synthesis" EXACT [] +xref: MetaCyc:PWY0-162 +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009221 +name: pyrimidine deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] +synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] +xref: MetaCyc:PWY0-166 +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009222 +name: pyrimidine ribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine ribonucleotide breakdown" EXACT [] +synonym: "pyrimidine ribonucleotide catabolism" EXACT [] +synonym: "pyrimidine ribonucleotide degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009223 +name: pyrimidine deoxyribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleotide degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process + +[Term] +id: GO:0009224 +name: CMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "CMP anabolism" EXACT [] +synonym: "CMP biosynthesis" EXACT [] +synonym: "CMP formation" EXACT [] +synonym: "CMP synthesis" EXACT [] +is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046035 ! CMP metabolic process + +[Term] +id: GO:0009225 +name: nucleotide-sugar metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "nucleotide-sugar metabolism" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process + +[Term] +id: GO:0009226 +name: nucleotide-sugar biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleotide-sugar anabolism" EXACT [] +synonym: "nucleotide-sugar biosynthesis" EXACT [] +synonym: "nucleotide-sugar formation" EXACT [] +synonym: "nucleotide-sugar synthesis" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0009227 +name: nucleotide-sugar catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nucleotide-sugar breakdown" EXACT [] +synonym: "nucleotide-sugar catabolism" EXACT [] +synonym: "nucleotide-sugar degradation" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0009228 +name: thiamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "thiamin anabolism" EXACT [] +synonym: "thiamin biosynthesis" EXACT [] +synonym: "thiamin formation" EXACT [] +synonym: "thiamin synthesis" EXACT [] +synonym: "thiamine biosynthesis" EXACT [] +synonym: "thiamine biosynthetic process" EXACT [] +synonym: "vitamin B1 biosynthesis" EXACT [] +synonym: "vitamin B1 biosynthetic process" EXACT [] +xref: MetaCyc:THISYN-PWY +is_a: GO:0006772 ! thiamin metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042724 ! thiamin and derivative biosynthetic process + +[Term] +id: GO:0009229 +name: thiamin diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713] +subset: gosubset_prok +synonym: "thiamin diphosphate anabolism" EXACT [] +synonym: "thiamin diphosphate biosynthesis" EXACT [] +synonym: "thiamin diphosphate formation" EXACT [] +synonym: "thiamin diphosphate synthesis" EXACT [] +synonym: "thiamin pyrophosphate biosynthesis" EXACT [] +synonym: "thiamin pyrophosphate biosynthetic process" EXACT [] +synonym: "thiamine diphosphate biosynthesis" EXACT [] +synonym: "thiamine diphosphate biosynthetic process" EXACT [] +synonym: "thiamine pyrophosphate biosynthesis" EXACT [] +synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] +synonym: "TPP biosynthesis" EXACT [] +synonym: "TPP biosynthetic process" EXACT [] +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0042357 ! thiamin diphosphate metabolic process +is_a: GO:0042724 ! thiamin and derivative biosynthetic process + +[Term] +id: GO:0009230 +name: thiamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "thiamin breakdown" EXACT [] +synonym: "thiamin catabolism" EXACT [] +synonym: "thiamin degradation" EXACT [] +synonym: "thiamine catabolic process" EXACT [] +synonym: "thiamine catabolism" EXACT [] +synonym: "vitamin B1 catabolic process" EXACT [] +synonym: "vitamin B1 catabolism" EXACT [] +is_a: GO:0006772 ! thiamin metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042725 ! thiamin and derivative catabolic process + +[Term] +id: GO:0009231 +name: riboflavin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "riboflavin anabolism" EXACT [] +synonym: "riboflavin biosynthesis" EXACT [] +synonym: "riboflavin formation" EXACT [] +synonym: "riboflavin synthesis" EXACT [] +synonym: "vitamin B2 biosynthesis" EXACT [] +synonym: "vitamin B2 biosynthetic process" EXACT [] +synonym: "vitamin G biosynthesis" EXACT [] +synonym: "vitamin G biosynthetic process" EXACT [] +xref: MetaCyc:RIBOSYN2-PWY +is_a: GO:0006771 ! riboflavin metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042727 ! riboflavin and derivative biosynthetic process + +[Term] +id: GO:0009232 +name: riboflavin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "riboflavin breakdown" EXACT [] +synonym: "riboflavin catabolism" EXACT [] +synonym: "riboflavin degradation" EXACT [] +synonym: "vitamin B2 catabolic process" EXACT [] +synonym: "vitamin B2 catabolism" EXACT [] +synonym: "vitamin G catabolic process" EXACT [] +synonym: "vitamin G catabolism" EXACT [] +is_a: GO:0006771 ! riboflavin metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042728 ! riboflavin and derivative catabolic process + +[Term] +id: GO:0009233 +name: menaquinone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "menaquinone metabolism" EXACT [] +synonym: "menatetrenone metabolic process" EXACT [] +synonym: "menatetrenone metabolism" EXACT [] +synonym: "multiprenylmenaquinone metabolic process" EXACT [] +synonym: "multiprenylmenaquinone metabolism" EXACT [] +synonym: "vitamin K2 metabolic process" EXACT [] +synonym: "vitamin K2 metabolism" EXACT [] +is_a: GO:0042373 ! vitamin K metabolic process + +[Term] +id: GO:0009234 +name: menaquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "menaquinone anabolism" EXACT [] +synonym: "menaquinone biosynthesis" EXACT [] +synonym: "menaquinone formation" EXACT [] +synonym: "menaquinone synthesis" EXACT [] +synonym: "menatetrenone biosynthesis" EXACT [] +synonym: "menatetrenone biosynthetic process" EXACT [] +synonym: "multiprenylmenaquinone biosynthesis" EXACT [] +synonym: "multiprenylmenaquinone biosynthetic process" EXACT [] +synonym: "vitamin K2 biosynthesis" EXACT [] +synonym: "vitamin K2 biosynthetic process" EXACT [] +xref: MetaCyc:MENAQUINONESYN-PWY +is_a: GO:0009233 ! menaquinone metabolic process +is_a: GO:0042371 ! vitamin K biosynthetic process + +[Term] +id: GO:0009235 +name: cobalamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] +subset: gosubset_prok +synonym: "cobalamin metabolism" EXACT [] +synonym: "vitamin B12 metabolic process" EXACT [] +synonym: "vitamin B12 metabolism" EXACT [] +synonym: "vitamin B12 reduction" NARROW [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0006778 ! porphyrin metabolic process + +[Term] +id: GO:0009236 +name: cobalamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cobalamin anabolism" EXACT [] +synonym: "cobalamin biosynthesis" EXACT [] +synonym: "cobalamin formation" EXACT [] +synonym: "cobalamin synthesis" EXACT [] +synonym: "vitamin B12 biosynthesis" EXACT [] +synonym: "vitamin B12 biosynthetic process" EXACT [] +is_a: GO:0006779 ! porphyrin biosynthetic process +is_a: GO:0009235 ! cobalamin metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process + +[Term] +id: GO:0009237 +name: siderophore metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684] +subset: gosubset_prok +synonym: "siderochrome metabolic process" NARROW [] +synonym: "siderochrome metabolism" NARROW [] +synonym: "siderophore metabolism" EXACT [] +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0009238 +name: enterobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684] +subset: gosubset_prok +synonym: "enterobactin metabolism" EXACT [] +synonym: "enterochelin metabolic process" EXACT [] +synonym: "enterochelin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0009239 +name: enterobactin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators] +subset: gosubset_prok +synonym: "enterobactin anabolism" EXACT [] +synonym: "enterobactin biosynthesis" EXACT [] +synonym: "enterobactin formation" EXACT [] +synonym: "enterobactin synthesis" EXACT [] +synonym: "enterobactin synthetase" RELATED [] +synonym: "enterochelin biosynthesis" EXACT [] +synonym: "enterochelin biosynthetic process" EXACT [] +xref: MetaCyc:ENTBACSYN-PWY +is_a: GO:0009238 ! enterobactin metabolic process +is_a: GO:0019540 ! siderophore biosynthetic process from catechol + +[Term] +id: GO:0009240 +name: isopentenyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "IPP biosynthesis" EXACT [] +synonym: "IPP biosynthetic process" EXACT [] +synonym: "isopentenyl diphosphate anabolism" EXACT [] +synonym: "isopentenyl diphosphate biosynthesis" EXACT [] +synonym: "isopentenyl diphosphate formation" EXACT [] +synonym: "isopentenyl diphosphate synthesis" EXACT [] +synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] +synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046490 ! isopentenyl diphosphate metabolic process +relationship: part_of GO:0008299 ! isoprenoid biosynthetic process + +[Term] +id: GO:0009242 +name: colanic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai] +subset: gosubset_prok +synonym: "colanic acid anabolism" EXACT [] +synonym: "colanic acid biosynthesis" EXACT [] +synonym: "colanic acid formation" EXACT [] +synonym: "colanic acid synthesis" EXACT [] +synonym: "M antigen biosynthesis" EXACT [] +synonym: "M antigen biosynthetic process" EXACT [] +xref: MetaCyc:COLANSYN-PWY +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046377 ! colanic acid metabolic process + +[Term] +id: GO:0009243 +name: O antigen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "O antigen anabolism" EXACT [] +synonym: "O antigen biosynthesis" EXACT [] +synonym: "O antigen formation" EXACT [] +synonym: "O antigen synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046402 ! O antigen metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0009244 +name: lipopolysaccharide core region biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipopolysaccharide core region anabolism" EXACT [] +synonym: "lipopolysaccharide core region biosynthesis" EXACT [] +synonym: "lipopolysaccharide core region formation" EXACT [] +synonym: "lipopolysaccharide core region synthesis" EXACT [] +synonym: "LPS core region biosynthetic process" EXACT [] +is_a: GO:0009312 ! oligosaccharide biosynthetic process +is_a: GO:0046401 ! lipopolysaccharide core region metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0009245 +name: lipid A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipid A anabolism" EXACT [] +synonym: "lipid A biosynthesis" EXACT [] +synonym: "lipid A formation" EXACT [] +synonym: "lipid A synthesis" EXACT [] +xref: MetaCyc:NAGLIPASYN-PWY +is_a: GO:0046493 ! lipid A metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0009246 +name: enterobacterial common antigen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] +subset: gosubset_prok +synonym: "enterobacterial common antigen anabolism" EXACT [] +synonym: "enterobacterial common antigen biosynthesis" EXACT [] +synonym: "enterobacterial common antigen formation" EXACT [] +synonym: "enterobacterial common antigen synthesis" EXACT [] +xref: MetaCyc:ECASYN-PWY +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046378 ! enterobacterial common antigen metabolic process + +[Term] +id: GO:0009247 +name: glycolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycolipid anabolism" EXACT [] +synonym: "glycolipid biosynthesis" EXACT [] +synonym: "glycolipid formation" EXACT [] +synonym: "glycolipid synthesis" EXACT [] +xref: MetaCyc:PWY-401 +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0046467 ! membrane lipid biosynthetic process + +[Term] +id: GO:0009248 +name: K antigen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "K antigen anabolism" EXACT [] +synonym: "K antigen biosynthesis" EXACT [] +synonym: "K antigen formation" EXACT [] +synonym: "K antigen synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046375 ! K antigen metabolic process + +[Term] +id: GO:0009249 +name: protein lipoylation +namespace: biological_process +def: "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018065 ! protein-cofactor linkage + +[Term] +id: GO:0009250 +name: glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] +subset: gosubset_prok +synonym: "glucan anabolism" EXACT [] +synonym: "glucan biosynthesis" EXACT [] +synonym: "glucan formation" EXACT [] +synonym: "glucan synthesis" EXACT [] +is_a: GO:0006073 ! glucan metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0009251 +name: glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] +subset: gosubset_prok +synonym: "glucan breakdown" EXACT [] +synonym: "glucan catabolism" EXACT [] +synonym: "glucan degradation" EXACT [] +is_a: GO:0006073 ! glucan metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0009252 +name: peptidoglycan biosynthetic process +namespace: biological_process +alt_id: GO:0009285 +def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "murein biosynthesis" EXACT [] +synonym: "murein biosynthetic process" EXACT [] +synonym: "peptidoglycan anabolism" EXACT [] +synonym: "peptidoglycan biosynthesis" EXACT [] +synonym: "peptidoglycan formation" EXACT [] +synonym: "peptidoglycan synthesis" EXACT [] +xref: MetaCyc:PEPTIDOGLYCANSYN-PWY +is_a: GO:0000270 ! peptidoglycan metabolic process +is_a: GO:0016051 ! carbohydrate biosynthetic process +relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0009253 +name: peptidoglycan catabolic process +namespace: biological_process +alt_id: GO:0009286 +def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "murein catabolic process" EXACT [] +synonym: "murein catabolism" EXACT [] +synonym: "peptidoglycan breakdown" EXACT [] +synonym: "peptidoglycan catabolism" EXACT [] +synonym: "peptidoglycan degradation" EXACT [] +is_a: GO:0000270 ! peptidoglycan metabolic process +is_a: GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0009254 +name: peptidoglycan turnover +namespace: biological_process +alt_id: GO:0009287 +def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl] +subset: gosubset_prok +synonym: "murein turnover" EXACT [] +is_a: GO:0000270 ! peptidoglycan metabolic process + +[Term] +id: GO:0009255 +name: Entner-Doudoroff pathway +namespace: biological_process +def: "A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +xref: MetaCyc:ENTNER-DOUDOROFF-PWY +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0009256 +name: 10-formyltetrahydrofolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] +subset: gosubset_prok +synonym: "10-formyl-THF metabolic process" EXACT [] +synonym: "10-formyl-THF metabolism" EXACT [] +synonym: "10-formyltetrahydrofolate metabolism" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process + +[Term] +id: GO:0009257 +name: 10-formyltetrahydrofolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] +subset: gosubset_prok +synonym: "10-formyl-THF biosynthesis" EXACT [] +synonym: "10-formyl-THF biosynthetic process" EXACT [] +synonym: "10-formyltetrahydrofolate anabolism" EXACT [] +synonym: "10-formyltetrahydrofolate biosynthesis" EXACT [] +synonym: "10-formyltetrahydrofolate formation" EXACT [] +synonym: "10-formyltetrahydrofolate synthesis" EXACT [] +xref: MetaCyc:1CMET2-PWY +xref: MetaCyc:PWY-3742 +xref: MetaCyc:PWY-3841 +is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process +is_a: GO:0009396 ! folic acid and derivative biosynthetic process + +[Term] +id: GO:0009258 +name: 10-formyltetrahydrofolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] +subset: gosubset_prok +synonym: "10-formyl-THF catabolic process" EXACT [] +synonym: "10-formyl-THF catabolism" EXACT [] +synonym: "10-formyltetrahydrofolate breakdown" EXACT [] +synonym: "10-formyltetrahydrofolate catabolism" EXACT [] +synonym: "10-formyltetrahydrofolate degradation" EXACT [] +is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process +is_a: GO:0009397 ! folic acid and derivative catabolic process + +[Term] +id: GO:0009259 +name: ribonucleotide metabolic process +namespace: biological_process +alt_id: GO:0009121 +def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009260 +name: ribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleotide anabolism" EXACT [] +synonym: "ribonucleotide biosynthesis" EXACT [] +synonym: "ribonucleotide formation" EXACT [] +synonym: "ribonucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009261 +name: ribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribonucleotide breakdown" EXACT [] +synonym: "ribonucleotide catabolism" EXACT [] +synonym: "ribonucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009262 +name: deoxyribonucleotide metabolic process +namespace: biological_process +alt_id: GO:0009122 +alt_id: GO:0009393 +def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleotide metabolism" EXACT [] +xref: MetaCyc:DEOXYRIBONUCMET-PWY +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009263 +name: deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleotide anabolism" EXACT [] +synonym: "deoxyribonucleotide biosynthesis" EXACT [] +synonym: "deoxyribonucleotide formation" EXACT [] +synonym: "deoxyribonucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009264 +name: deoxyribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribonucleotide breakdown" EXACT [] +synonym: "deoxyribonucleotide catabolism" EXACT [] +synonym: "deoxyribonucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009265 +name: 2'-deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:mah] +subset: gosubset_prok +synonym: "2'-deoxyribonucleotide anabolism" EXACT [] +synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] +synonym: "2'-deoxyribonucleotide formation" EXACT [] +synonym: "2'-deoxyribonucleotide synthesis" EXACT [] +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process +is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process + +[Term] +id: GO:0009266 +name: response to temperature stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] +subset: gosubset_prok +synonym: "response to thermal stimulus" EXACT [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009267 +name: cellular response to starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] +subset: gosubset_prok +is_a: GO:0031669 ! cellular response to nutrient levels +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0009268 +name: response to pH +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009269 +name: response to desiccation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] +subset: gosubset_prok +synonym: "desiccation tolerance" RELATED [] +is_a: GO:0009414 ! response to water deprivation + +[Term] +id: GO:0009270 +name: response to humidity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0009271 +name: phage shock +namespace: biological_process +def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608] +subset: gosubset_prok +is_a: GO:0006950 ! response to stress +is_a: GO:0009615 ! response to virus + +[Term] +id: GO:0009272 +name: fungal-type cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] +synonym: "cell wall anabolism (sensu Fungi)" EXACT [] +synonym: "cell wall assembly (sensu Fungi)" EXACT [] +synonym: "cell wall biosynthetic process (sensu Fungi)" EXACT [] +synonym: "cell wall formation (sensu Fungi)" EXACT [] +synonym: "cell wall synthesis (sensu Fungi)" EXACT [] +synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [] +is_a: GO:0031505 ! fungal-type cell wall organization +is_a: GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0009273 +name: peptidoglycan-based cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall." [GOC:go_curators] +subset: gosubset_prok +synonym: "cell envelope biosynthesis" BROAD [] +synonym: "cell envelope biosynthetic process" BROAD [] +synonym: "cell wall anabolism (sensu Bacteria)" EXACT [] +synonym: "cell wall assembly (sensu Bacteria)" EXACT [] +synonym: "cell wall biosynthetic process (sensu Bacteria)" EXACT [] +synonym: "cell wall formation (sensu Bacteria)" EXACT [] +synonym: "cell wall synthesis (sensu Bacteria)" EXACT [] +is_a: GO:0031504 ! peptidoglycan-based cell wall organization +is_a: GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0009274 +name: peptidoglycan-based cell wall +namespace: cellular_component +def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan, a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids; also called murein. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mlg, ISBN:0815108893] +subset: gosubset_prok +synonym: "cell wall (sensu Bacteria)" EXACT [] +synonym: "envelope (sensu Bacteria)" BROAD [] +synonym: "murein sacculus" RELATED [] +synonym: "peptidoglycan" NARROW [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0009275 +name: Gram-positive-bacterium-type cell wall +namespace: cellular_component +def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. As in but not restricted to the Gram-positive bacteria." [GOC:mlg, ISBN:0051406910, ISBN:0815108893] +subset: gosubset_prok +synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] +synonym: "cell wall (sensu Firmicutes)" EXACT [] +synonym: "cell wall (sensu Gram-positive Bacteria)" EXACT [] +synonym: "cell wall of Gram-positive Bacteria" EXACT [] +is_a: GO:0009274 ! peptidoglycan-based cell wall + +[Term] +id: GO:0009276 +name: Gram-negative-bacterium-type cell wall +namespace: cellular_component +def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. As in but not restricted to the Gram-negative bacteria." [GOC:mlg, ISBN:0815108893] +subset: gosubset_prok +synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] +synonym: "cell wall (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall (sensu Proteobacteria)" EXACT [] +synonym: "cell wall inner membrane" EXACT [] +is_a: GO:0009274 ! peptidoglycan-based cell wall +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0030313 ! cell envelope + +[Term] +id: GO:0009277 +name: fungal-type cell wall +namespace: cellular_component +def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] +synonym: "beta-glucan-containing cell wall" RELATED [] +synonym: "cell wall (sensu Fungi)" EXACT [] +synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] +synonym: "chitin-containing cell wall" RELATED [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0009278 +name: murein sacculus +namespace: cellular_component +def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma] +comment: This term was made obsolete because it was defined inaccurately. +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0009279 +name: cell outer membrane +namespace: cellular_component +def: "A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:mtg_sensu, ISBN:0135712254] +subset: gosubset_prok +synonym: "outer membrane (sensu Gram-negative Bacteria)" EXACT [] +synonym: "outer membrane (sensu Proteobacteria)" EXACT [] +synonym: "outer membrane of cell" EXACT [] +is_a: GO:0019867 ! outer membrane +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0030313 ! cell envelope + +[Term] +id: GO:0009280 +name: cell wall inner membrane +namespace: cellular_component +def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma] +comment: This term was made obsolete because it was defined inaccurately. +synonym: "cytoplasmic membrane" BROAD [] +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0009288 +name: flagellin-based flagellum +namespace: cellular_component +def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:jh2, GOC:mtg_sensu, PMID:7787060] +subset: gosubset_prok +synonym: "flagellum (sensu Bacteria)" EXACT [] +is_a: GO:0019861 ! flagellum + +[Term] +id: GO:0009289 +name: fimbrium +namespace: cellular_component +def: "A proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter." [ISBN:0598034692] +subset: goslim_pir +subset: gosubset_prok +synonym: "fimbria" BROAD [] +synonym: "fimbriae" EXACT [] +synonym: "pilus" BROAD [] +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0009290 +name: DNA import into cell during transformation +namespace: biological_process +def: "The directed movement of DNA into a cell during the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai] +subset: gosubset_prok +synonym: "cellular DNA import during transformation" EXACT [] +synonym: "cellular DNA uptake" BROAD [] +synonym: "DNA import into cell" BROAD [] +synonym: "DNA transport into cell during transformation" EXACT [] +is_a: GO:0051027 ! DNA transport +relationship: part_of GO:0009294 ! DNA mediated transformation + +[Term] +id: GO:0009291 +name: unidirectional conjugation +namespace: biological_process +def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [ISBN:0387520546] +subset: gosubset_prok +synonym: "conjugation (sensu Bacteria)" NARROW [] +synonym: "mating (sensu Bacteria)" NARROW [] +is_a: GO:0000746 ! conjugation +is_a: GO:0009292 ! genetic transfer + +[Term] +id: GO:0009292 +name: genetic transfer +namespace: biological_process +def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt] +subset: goslim_pir +subset: gosubset_prok +synonym: "genetic exchange" BROAD [] +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0009293 +name: transduction +namespace: biological_process +def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0009292 ! genetic transfer + +[Term] +id: GO:0009294 +name: DNA mediated transformation +namespace: biological_process +def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "DNA-mediated transformation" EXACT [] +is_a: GO:0009292 ! genetic transfer + +[Term] +id: GO:0009295 +name: nucleoid +namespace: cellular_component +def: "The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ma, ISBN:3540076689] +subset: gosubset_prok +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009296 +name: flagellum biogenesis +namespace: biological_process +def: "The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "flagella biogenesis" EXACT [] +is_a: GO:0030031 ! cell projection biogenesis +is_a: GO:0043064 ! flagellum organization + +[Term] +id: GO:0009297 +name: pilus biogenesis +namespace: biological_process +def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:mcc2] +subset: gosubset_prok +synonym: "fimbria assembly" NARROW [] +synonym: "fimbria biogenesis" RELATED [] +synonym: "fimbriae assembly" NARROW [] +synonym: "fimbriae biogenesis" NARROW [] +synonym: "fimbrial assembly" NARROW [] +synonym: "fimbrial biogenesis" NARROW [] +synonym: "fimbrium assembly" NARROW [] +synonym: "fimbrium biogenesis" NARROW [] +synonym: "pili biosynthesis" EXACT [] +synonym: "pili biosynthetic process" EXACT [] +synonym: "pilus biosynthesis" EXACT [] +is_a: GO:0043711 ! pilus organization + +[Term] +id: GO:0009298 +name: GDP-mannose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP-mannose anabolism" EXACT [] +synonym: "GDP-mannose biosynthesis" EXACT [] +synonym: "GDP-mannose formation" EXACT [] +synonym: "GDP-mannose synthesis" EXACT [] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019307 ! mannose biosynthetic process +is_a: GO:0019673 ! GDP-mannose metabolic process + +[Term] +id: GO:0009299 +name: mRNA transcription +namespace: biological_process +def: "The synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl] +subset: gosubset_prok +synonym: "mRNA biosynthesis" BROAD [] +synonym: "mRNA biosynthetic process" BROAD [] +synonym: "mRNA synthesis" BROAD [] +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0009300 +name: antisense RNA transcription +namespace: biological_process +def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006351 ! transcription, DNA-dependent +is_a: GO:0042868 ! antisense RNA metabolic process + +[Term] +id: GO:0009301 +name: snRNA transcription +namespace: biological_process +def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382] +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0009302 +name: snoRNA transcription +namespace: biological_process +def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl] +is_a: GO:0006351 ! transcription, DNA-dependent +is_a: GO:0016074 ! snoRNA metabolic process + +[Term] +id: GO:0009303 +name: rRNA transcription +namespace: biological_process +def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "rRNA biosynthesis" BROAD [] +synonym: "rRNA biosynthetic process" BROAD [] +synonym: "rRNA synthesis" BROAD [] +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0009304 +name: tRNA transcription +namespace: biological_process +def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl] +subset: gosubset_prok +synonym: "tRNA biosynthesis" BROAD [] +synonym: "tRNA biosynthetic process" BROAD [] +synonym: "tRNA synthesis" BROAD [] +is_a: GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0009305 +name: protein amino acid biotinylation +namespace: biological_process +def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0009306 +name: protein secretion +namespace: biological_process +alt_id: GO:0045166 +alt_id: GO:0045731 +def: "The regulated release of proteins from a cell or group of cells." [GOC:ai] +subset: gosubset_prok +synonym: "glycoprotein secretion" NARROW [] +synonym: "protein secretion during cell fate commitment" NARROW [] +synonym: "protein secretion resulting in cell fate commitment" NARROW [] +is_a: GO:0015031 ! protein transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0009307 +name: DNA restriction-modification system +namespace: biological_process +def: "Any process that protect an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA." [GOC:mah] +subset: gosubset_prok +synonym: "DNA restriction" BROAD [] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0009308 +name: cellular amine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "amine metabolism" EXACT [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0009309 +name: amine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "amine anabolism" EXACT [] +synonym: "amine biosynthesis" EXACT [] +synonym: "amine formation" EXACT [] +synonym: "amine synthesis" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0044271 ! nitrogen compound biosynthetic process + +[Term] +id: GO:0009310 +name: amine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "amine breakdown" EXACT [] +synonym: "amine catabolism" EXACT [] +synonym: "amine degradation" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0009311 +name: oligosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "oligosaccharide metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0009312 +name: oligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "oligosaccharide anabolism" EXACT [] +synonym: "oligosaccharide biosynthesis" EXACT [] +synonym: "oligosaccharide formation" EXACT [] +synonym: "oligosaccharide synthesis" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0016051 ! carbohydrate biosynthetic process + +[Term] +id: GO:0009313 +name: oligosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "oligosaccharide breakdown" EXACT [] +synonym: "oligosaccharide catabolism" EXACT [] +synonym: "oligosaccharide degradation" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0009314 +name: response to radiation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, http://en.wikipedia.org/wiki/Electromagnetic_radiation] +comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. +subset: gosubset_prok +synonym: "response to electromagnetic radiation stimulus" EXACT [] +synonym: "response to radiation stimulus" EXACT [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009315 +name: drug resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0042493 + +[Term] +id: GO:0009316 +name: 3-isopropylmalate dehydratase complex +namespace: cellular_component +def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, UniProtKB:Q8TW31] +comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. +subset: gosubset_prok +synonym: "isopropylmalate isomerase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0009317 +name: acetyl-CoA carboxylase complex +namespace: cellular_component +def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, UniProtKB:P24182] +subset: goslim_pir +subset: gosubset_prok +synonym: "ACCase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009318 +name: exodeoxyribonuclease VII complex +namespace: cellular_component +def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009319 +name: cytochrome o ubiquinol oxidase complex +namespace: cellular_component +def: "A bacterial heterooctameric enzyme composed of two A chains, two B chains, two C chains and two D chains. Possesses cytochrome o ubiquinol oxidase activity." [GOC:jl, UniProtKB:P0ABJ3] +comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016021 ! integral to membrane + +[Term] +id: GO:0009320 +name: phosphoribosylaminoimidazole carboxylase complex +namespace: cellular_component +def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] +comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009321 +name: alkyl hydroperoxide reductase complex +namespace: cellular_component +def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, UniProtKB:P0A0B5] +comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009322 +name: trimethylamine-N-oxide reductase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009323 +name: ribosomal-protein-alanine N-acetyltransferase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] +is_a: GO:0031248 ! protein acetyltransferase complex + +[Term] +id: GO:0009324 +name: D-amino-acid dehydrogenase complex +namespace: cellular_component +def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] +comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0009325 +name: nitrate reductase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009326 +name: formate dehydrogenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009327 +name: NAD(P)+ transhydrogenase complex (AB-specific) +namespace: cellular_component +def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009328 +name: phenylalanine-tRNA ligase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009329 +name: acetate CoA-transferase complex +namespace: cellular_component +def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, UniProtKB:P08193] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex + +[Term] +id: GO:0009330 +name: DNA topoisomerase complex (ATP-hydrolyzing) +namespace: cellular_component +def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] +comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009331 +name: glycerol-3-phosphate dehydrogenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.99.5] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009332 +name: glutamate-tRNA ligase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009333 +name: cysteine synthase complex +namespace: cellular_component +def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009334 +name: 3-phenylpropionate dioxygenase complex +namespace: cellular_component +def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, UniProtKB:P77650] +comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009335 +name: holo-[acyl-carrier protein] synthase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7] +comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. +synonym: "holo-ACP synthase complex" EXACT [] +is_obsolete: true +consider: GO:0005835 + +[Term] +id: GO:0009336 +name: sulfate adenylyltransferase complex (ATP) +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] +synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009337 +name: sulfite reductase complex (NADPH) +namespace: cellular_component +def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of hydrogen sulfide to sulfide." [BRENDA:1.8.1.2, GOC:jl] +comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. +subset: gosubset_prok +synonym: "sulphite reductase complex (NADPH)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009338 +name: exodeoxyribonuclease V complex +namespace: cellular_component +def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009339 +name: glycolate oxidase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009340 +name: DNA topoisomerase IV complex +namespace: cellular_component +def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, PARC and PARE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, UniProtKB:Q45066] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009341 +name: beta-galactosidase complex +namespace: cellular_component +def: "A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23, UniProtKB:P06864] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0009342 +name: glutamate synthase complex (NADPH) +namespace: cellular_component +def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] +subset: gosubset_prok +is_a: GO:0031026 ! glutamate synthase complex + +[Term] +id: GO:0009343 +name: biotin carboxylase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex + +[Term] +id: GO:0009344 +name: nitrite reductase complex [NAD(P)H] +namespace: cellular_component +def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] +comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009345 +name: glycine-tRNA ligase complex +namespace: cellular_component +def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, UniProtKB:Q10039, UniProtKB:Q8YVJ2] +subset: gosubset_prok +synonym: "glycine-tRNA synthetase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009346 +name: citrate lyase complex +namespace: cellular_component +def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009347 +name: aspartate carbamoyltransferase complex +namespace: cellular_component +def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] +comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009348 +name: ornithine carbamoyltransferase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of a carbamoyl to ornithine, forming citrulline." [EC:2.1.3.3] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009349 +name: riboflavin synthase complex +namespace: cellular_component +def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009350 +name: ethanolamine ammonia-lyase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009351 +name: dihydrolipoamide S-acyltransferase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12] +comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide. +is_obsolete: true + +[Term] +id: GO:0009352 +name: dihydrolipoyl dehydrogenase complex +namespace: cellular_component +def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah] +comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. +synonym: "dihydrolipoamide dehydrogenase complex" EXACT [] +is_obsolete: true +consider: GO:0004148 +consider: GO:0045240 +consider: GO:0045254 + +[Term] +id: GO:0009353 +name: mitochondrial oxoglutarate dehydrogenase complex +namespace: cellular_component +def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix." [GOC:mtg_sensu, UniProtKB:Q60597] +comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. +synonym: "oxoglutarate dehydrogenase complex (sensu Eukaryota)" EXACT [] +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0045252 ! oxoglutarate dehydrogenase complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0009354 +name: dihydrolipoamide S-succinyltransferase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61] +comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. +is_obsolete: true +consider: GO:0045252 + +[Term] +id: GO:0009355 +name: DNA polymerase V complex +namespace: cellular_component +def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] +is_a: GO:0042575 ! DNA polymerase complex + +[Term] +id: GO:0009356 +name: aminodeoxychorismate synthase complex +namespace: cellular_component +def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] +synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] +synonym: "ADC synthase complex" EXACT [] +synonym: "p-aminobenzoate synthetase complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009357 +name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009358 +name: polyphosphate kinase complex +namespace: cellular_component +def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] +comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009359 +name: Type II site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] +subset: gosubset_prok +synonym: "Type II restriction enzyme complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009360 +name: DNA polymerase III complex +namespace: cellular_component +def: "A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:11525729, PMID:12940977] +subset: gosubset_prok +is_a: GO:0042575 ! DNA polymerase complex + +[Term] +id: GO:0009361 +name: succinate-CoA ligase complex (ADP-forming) +namespace: cellular_component +def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl] +subset: gosubset_prok +is_a: GO:0042709 ! succinate-CoA ligase complex + +[Term] +id: GO:0009365 +name: protein histidine kinase complex +namespace: cellular_component +def: "A complex that possesses protein histidine kinase activity." [GOC:mah] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0009366 +name: enterobactin synthetase complex +namespace: cellular_component +def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [UniProtKB:P15048] +subset: gosubset_prok +synonym: "enterochelin synthetase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009367 +name: prepilin peptidase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0009368 +name: endopeptidase Clp complex +namespace: cellular_component +def: "An enzymatically active or inactive multimeric complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits." [PMID:11352464] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009369 +name: quorum sensing signal generator activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0009370 +name: quorum sensing response regulator activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0009371 +name: positive regulation of transcription by pheromones +namespace: biological_process +def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of transcription by pheromones" NARROW [] +synonym: "stimulation of transcription by pheromones" NARROW [] +synonym: "up regulation of transcription by pheromones" EXACT [] +synonym: "up-regulation of transcription by pheromones" EXACT [] +synonym: "upregulation of transcription by pheromones" EXACT [] +is_a: GO:0009373 ! regulation of transcription by pheromones +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent + +[Term] +id: GO:0009372 +name: quorum sensing +namespace: biological_process +def: "The process by which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518] +subset: goslim_pir +subset: gosubset_prok +synonym: "quorum sensing system" EXACT [] +is_a: GO:0048874 ! homeostasis of number of cells in a free-living population + +[Term] +id: GO:0009373 +name: regulation of transcription by pheromones +namespace: biological_process +def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0019236 ! response to pheromone + +[Term] +id: GO:0009374 +name: biotin binding +namespace: molecular_function +def: "Interacting selectively with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "vitamin B7 binding" EXACT [] +synonym: "vitamin H binding" EXACT [] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0009375 +name: ferredoxin hydrogenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] +subset: gosubset_prok +synonym: "hydrogenase complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009376 +name: HslUV protease complex +namespace: cellular_component +def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex." [PMID:12670962] +subset: gosubset_prok +synonym: "ClpYQ protease complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009377 +name: HslUV protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +is_obsolete: true +replaced_by: GO:0070011 + +[Term] +id: GO:0009378 +name: four-way junction helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] +subset: gosubset_prok +synonym: "Holliday junction helicase activity" NARROW [] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0009379 +name: Holliday junction helicase complex +namespace: cellular_component +def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA ." [PMID:16935884, PMID:9442895] +subset: gosubset_prok +is_a: GO:0033202 ! DNA helicase complex +relationship: part_of GO:0048476 ! Holliday junction resolvase complex + +[Term] +id: GO:0009380 +name: excinuclease repair complex +namespace: cellular_component +def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:15192705] +subset: gosubset_prok +synonym: "excinuclease ABC complex" EXACT [] +synonym: "UvrABC excinuclease complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009381 +name: excinuclease ABC activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0009382 +name: imidazoleglycerol-phosphate synthase complex +namespace: cellular_component +def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] +comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. +subset: gosubset_prok +synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009383 +name: rRNA (cytosine-C5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544] +synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW [] +synonym: "rRNA m5C967 methyltransferase activity" NARROW [] +xref: EC:2.1.1.- +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity + +[Term] +id: GO:0009384 +name: N-acylmannosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] +subset: gosubset_prok +synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60] +synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] +synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60] +synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60] +synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60] +synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] +synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] +synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] +synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60] +xref: EC:2.7.1.60 +xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0009385 +name: N-acylmannosamine-6-phosphate 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] +synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] +xref: EC:5.-.-.- +xref: MetaCyc:NANE-RXN +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0009386 +name: translational attenuation +namespace: biological_process +def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513] +subset: gosubset_prok +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0009388 +name: antisense RNA +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0009389 +name: dimethyl sulfoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_enzymeID:e0188] +subset: gosubset_prok +synonym: "dimethyl sulphoxide reductase activity" EXACT [] +xref: EC:1.8.99.- +xref: UM-BBD_enzymeID:e0188 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0009390 +name: dimethyl sulfoxide reductase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] +synonym: "dimethyl sulphoxide reductase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009391 +name: ribonucleotide reductase activating enzyme activity +namespace: molecular_function +xref: EC:1.97.1.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0009392 +name: N-acetyl-anhydromuramoyl-L-alanine amidase activity +namespace: molecular_function +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0009394 +name: 2'-deoxyribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:mah] +subset: gosubset_prok +synonym: "2'-deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0009262 ! deoxyribonucleotide metabolic process + +[Term] +id: GO:0009395 +name: phospholipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phospholipid breakdown" EXACT [] +synonym: "phospholipid catabolism" EXACT [] +synonym: "phospholipid degradation" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0046466 ! membrane lipid catabolic process + +[Term] +id: GO:0009396 +name: folic acid and derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] +subset: gosubset_prok +synonym: "folate and derivative biosynthesis" EXACT [] +synonym: "folate and derivative biosynthetic process" EXACT [] +synonym: "folic acid and derivative anabolism" EXACT [] +synonym: "folic acid and derivative biosynthesis" EXACT [] +synonym: "folic acid and derivative formation" EXACT [] +synonym: "folic acid and derivative synthesis" EXACT [] +synonym: "vitamin B9 and derivative biosynthesis" EXACT [] +synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] +synonym: "vitamin M and derivative biosynthesis" EXACT [] +synonym: "vitamin M and derivative biosynthetic process" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process + +[Term] +id: GO:0009397 +name: folic acid and derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai] +subset: gosubset_prok +synonym: "folate and derivative catabolic process" EXACT [] +synonym: "folate and derivative catabolism" EXACT [] +synonym: "folic acid and derivative breakdown" EXACT [] +synonym: "folic acid and derivative catabolism" EXACT [] +synonym: "folic acid and derivative degradation" EXACT [] +synonym: "vitamin B9 and derivative catabolic process" EXACT [] +synonym: "vitamin B9 and derivative catabolism" EXACT [] +synonym: "vitamin M and derivative catabolic process" EXACT [] +synonym: "vitamin M and derivative catabolism" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process +is_a: GO:0009109 ! coenzyme catabolic process + +[Term] +id: GO:0009398 +name: FMN biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "FMN anabolism" EXACT [] +synonym: "FMN biosynthesis" EXACT [] +synonym: "FMN formation" EXACT [] +synonym: "FMN synthesis" EXACT [] +xref: MetaCyc:RIBOSYN2-PWYRI +is_a: GO:0006746 ! FADH2 metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0042727 ! riboflavin and derivative biosynthetic process +is_a: GO:0046444 ! FMN metabolic process + +[Term] +id: GO:0009399 +name: nitrogen fixation +namespace: biological_process +def: "The process by which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [http://en.wikipedia.org/wiki/Nitrogen_fixation] +subset: gosubset_prok +xref: MetaCyc:N2FIX-PWY +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0009400 +name: receptor signaling protein serine/threonine phosphatase activity +namespace: molecular_function +synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0009401 +name: phosphoenolpyruvate-dependent sugar phosphotransferase system +namespace: biological_process +def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html] +subset: gosubset_prok +synonym: "PTS system" NARROW [] +is_a: GO:0007165 ! signal transduction +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0009402 +name: toxin resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0009636 + +[Term] +id: GO:0009403 +name: toxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "toxin anabolism" EXACT [] +synonym: "toxin biosynthesis" EXACT [] +synonym: "toxin formation" EXACT [] +synonym: "toxin synthesis" EXACT [] +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0009404 +name: toxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] +subset: goslim_pir +subset: gosubset_prok +synonym: "toxin metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0044237 ! cellular metabolic process +relationship: part_of GO:0009636 ! response to toxin + +[Term] +id: GO:0009405 +name: pathogenesis +namespace: biological_process +def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] +comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. +subset: goslim_candida +subset: goslim_goa +subset: gosubset_prok +synonym: "channel-forming toxin activity" RELATED [] +synonym: "cytotoxin activity" RELATED [] +synonym: "endotoxin activity" RELATED [] +synonym: "enterotoxin activity" RELATED [] +synonym: "exotoxin activity" RELATED [] +synonym: "lipoprotein toxin" RELATED [] +synonym: "neurotoxin activity" RELATED [] +synonym: "pore-forming toxin activity" RELATED [] +synonym: "toxin activity" RELATED [] +synonym: "virulence" RELATED [] +is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0009406 +name: virulence +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a phenotype rather than a biological process. +is_obsolete: true +consider: GO:0009405 +consider: GO:0016032 + +[Term] +id: GO:0009407 +name: toxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "toxin breakdown" EXACT [] +synonym: "toxin catabolism" EXACT [] +synonym: "toxin degradation" EXACT [] +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0009408 +name: response to heat +namespace: biological_process +alt_id: GO:0006951 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] +subset: gosubset_prok +synonym: "response to heat shock" NARROW [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0009409 +name: response to cold +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] +subset: gosubset_prok +synonym: "freezing tolerance" RELATED [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0009410 +name: response to xenobiotic stimulus +namespace: biological_process +alt_id: GO:0017104 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0009411 +name: response to UV +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] +subset: gosubset_prok +synonym: "response to ultraviolet light stimulus" EXACT [] +synonym: "response to ultraviolet radiation stimulus" EXACT [] +synonym: "response to UV light stimulus" EXACT [] +synonym: "response to UV radiation stimulus" EXACT [] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009412 +name: response to heavy metal +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +is_obsolete: true +consider: GO:0010038 + +[Term] +id: GO:0009413 +name: response to flooding +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr] +comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. +is_a: GO:0006950 ! response to stress +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0009414 +name: response to water deprivation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] +subset: gosubset_prok +synonym: "drought tolerance" RELATED [] +synonym: "response to dehydration" EXACT [] +synonym: "response to drought" EXACT [] +synonym: "response to thirst" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0009415 +name: response to water +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009416 +name: response to light stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] +subset: gosubset_prok +is_a: GO:0009314 ! response to radiation + +[Term] +id: GO:0009417 +name: fimbrin +namespace: cellular_component +def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0009289 + +[Term] +id: GO:0009418 +name: fimbrial shaft +namespace: cellular_component +def: "The long, slender, mid section of a fimbrium." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044443 ! fimbrial part + +[Term] +id: GO:0009419 +name: fimbrial tip +namespace: cellular_component +def: "The pointed extremity furthest from the cell of a fimbrium." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044443 ! fimbrial part + +[Term] +id: GO:0009420 +name: flagellin-based flagellum filament +namespace: cellular_component +def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar filament" EXACT [] +synonym: "flagellar filament (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part + +[Term] +id: GO:0009421 +name: flagellin-based flagellum filament cap +namespace: cellular_component +def: "The proteinaceous structure at the distal tip of the flagellar filament." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar filament cap" EXACT [] +synonym: "flagellar filament cap (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0009420 ! flagellin-based flagellum filament + +[Term] +id: GO:0009422 +name: flagellin-based flagellum hook-filament junction +namespace: cellular_component +def: "The region of the flagellum where the hook and filament meet." [GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar hook-filament junction" EXACT [] +synonym: "flagellar hook-filament junction (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part + +[Term] +id: GO:0009423 +name: chorismate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] +subset: gosubset_prok +synonym: "chorismate anabolism" EXACT [] +synonym: "chorismate biosynthesis" EXACT [] +synonym: "chorismate formation" EXACT [] +synonym: "chorismate synthesis" EXACT [] +xref: MetaCyc:ARO-PWY +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0009424 +name: flagellin-based flagellum hook +namespace: cellular_component +def: "The portion of the flagellum that connects the filament to the basal body." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar hook" EXACT [] +synonym: "flagellar hook (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part + +[Term] +id: GO:0009425 +name: flagellin-based flagellum basal body +namespace: cellular_component +def: "One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring)." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part + +[Term] +id: GO:0009426 +name: flagellin-based flagellum basal body, distal rod +namespace: cellular_component +def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, distal rod" EXACT [] +synonym: "flagellar basal body, distal rod (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0030694 ! flagellin-based flagellum basal body, rod + +[Term] +id: GO:0009427 +name: flagellin-based flagellum basal body, distal rod, L ring +namespace: cellular_component +def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, distal rod, L ring" EXACT [] +synonym: "flagellar basal body, distal rod, L ring (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0009426 ! flagellin-based flagellum basal body, distal rod + +[Term] +id: GO:0009428 +name: flagellin-based flagellum basal body, distal rod, P ring +namespace: cellular_component +def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, distal rod, P ring" RELATED [] +synonym: "flagellar basal body, distal rod, P ring (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0009426 ! flagellin-based flagellum basal body, distal rod + +[Term] +id: GO:0009429 +name: flagellin-based flagellum basal body, proximal rod +namespace: cellular_component +def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, proximal rod" EXACT [] +synonym: "flagellar basal body, proximal rod (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0030694 ! flagellin-based flagellum basal body, rod + +[Term] +id: GO:0009431 +name: flagellin-based flagellum basal body, MS ring +namespace: cellular_component +alt_id: GO:0009430 +def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, mounting plate (sensu Bacteria)" EXACT [] +synonym: "flagellar basal body, MS ring" EXACT [] +synonym: "flagellar basal body, MS ring (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0009425 ! flagellin-based flagellum basal body + +[Term] +id: GO:0009432 +name: SOS response +namespace: biological_process +def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0031668 ! cellular response to extracellular stimulus +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0009433 +name: flagellin-based flagellum basal body, C ring +namespace: cellular_component +def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, C ring" EXACT [] +synonym: "flagellar basal body, C ring (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0009425 ! flagellin-based flagellum basal body + +[Term] +id: GO:0009434 +name: microtubule-based flagellum +namespace: cellular_component +def: "A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:mtg_sensu, ISBN:0815316194] +comment: See also the cellular component term 'cilium ; GO:0005929'. +synonym: "flagellum (sensu Eukaryota)" EXACT [] +is_a: GO:0019861 ! flagellum +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0009435 +name: NAD biosynthetic process +namespace: biological_process +alt_id: GO:0006736 +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] +subset: gosubset_prok +synonym: "NAD (oxidized) biosynthesis" EXACT [] +synonym: "NAD (oxidized) biosynthetic process" EXACT [] +synonym: "NAD (reduced) biosynthesis" EXACT [] +synonym: "NAD (reduced) biosynthetic process" EXACT [] +synonym: "NAD anabolism" EXACT [] +synonym: "NAD biosynthesis" EXACT [] +synonym: "NAD formation" EXACT [] +synonym: "NAD synthesis" EXACT [] +synonym: "NADH biosynthesis" EXACT [] +synonym: "NADH biosynthetic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] +synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT [] +synonym: "oxidized NAD biosynthesis" EXACT [] +synonym: "oxidized NAD biosynthetic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT [] +synonym: "reduced NAD biosynthesis" EXACT [] +synonym: "reduced NAD biosynthetic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT [] +is_a: GO:0019363 ! pyridine nucleotide biosynthetic process +is_a: GO:0019674 ! NAD metabolic process + +[Term] +id: GO:0009436 +name: glyoxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glyoxylate breakdown" EXACT [] +synonym: "glyoxylate catabolism" EXACT [] +synonym: "glyoxylate degradation" EXACT [] +xref: MetaCyc:GLYOXDEG-PWY +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:0046487 ! glyoxylate metabolic process + +[Term] +id: GO:0009437 +name: carnitine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carnitine metabolism" EXACT [] +synonym: "vitamin Bt metabolic process" EXACT [] +synonym: "vitamin Bt metabolism" EXACT [] +xref: MetaCyc:CARNMET2-PWY +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009438 +name: methylglyoxal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "methylglyoxal bypass" NARROW [] +synonym: "methylglyoxal metabolism" EXACT [] +synonym: "methylglyoxal pathway" NARROW [] +xref: MetaCyc:METHGLYUT-PWY +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:0009439 +name: cyanate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanate metabolism" EXACT [] +xref: MetaCyc:CYANCAT-PWY +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0009440 +name: cyanate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanate breakdown" EXACT [] +synonym: "cyanate catabolism" EXACT [] +synonym: "cyanate degradation" EXACT [] +is_a: GO:0009439 ! cyanate metabolic process +is_a: GO:0019754 ! one-carbon compound catabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0009441 +name: glycolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycolate metabolism" EXACT [] +xref: MetaCyc:GLYCOLATEMET-PWY +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009442 +name: allantoin assimilation pathway +namespace: biological_process +def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41] +subset: gosubset_prok +synonym: "allantoin catabolic process via ureidoglycolate" EXACT [] +synonym: "allantoin catabolism via ureidoglycolate" EXACT [] +synonym: "allantoin degradation pathway" RELATED [] +xref: MetaCyc:PWY0-41 +is_a: GO:0000256 ! allantoin catabolic process + +[Term] +id: GO:0009443 +name: pyridoxal 5'-phosphate salvage +namespace: biological_process +def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "pyridoxal 5' phosphate salvage" EXACT [] +xref: MetaCyc:PLPSAL-PWY +is_a: GO:0008614 ! pyridoxine metabolic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0009444 +name: pyruvate oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:PYRUVOX-PWY +is_a: GO:0006090 ! pyruvate metabolic process + +[Term] +id: GO:0009445 +name: putrescine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai] +subset: gosubset_prok +synonym: "putrescine metabolism" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0009446 +name: putrescine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "putrescine anabolism" EXACT [] +synonym: "putrescine biosynthesis" EXACT [] +synonym: "putrescine formation" EXACT [] +synonym: "putrescine synthesis" EXACT [] +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0009445 ! putrescine metabolic process + +[Term] +id: GO:0009447 +name: putrescine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai] +subset: gosubset_prok +synonym: "putrescine breakdown" EXACT [] +synonym: "putrescine catabolism" EXACT [] +synonym: "putrescine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0009445 ! putrescine metabolic process + +[Term] +id: GO:0009448 +name: gamma-aminobutyric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. +subset: gosubset_prok +synonym: "4-aminobutanoate metabolic process" EXACT [] +synonym: "4-aminobutanoate metabolism" EXACT [] +synonym: "4-aminobutyrate metabolic process" EXACT [] +synonym: "4-aminobutyrate metabolism" EXACT [] +synonym: "GABA metabolic process" EXACT [] +synonym: "GABA metabolism" EXACT [] +synonym: "gamma-aminobutyric acid metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:0009449 +name: gamma-aminobutyric acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] +comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. +synonym: "4-aminobutanoate biosynthesis" EXACT [] +synonym: "4-aminobutanoate biosynthetic process" EXACT [] +synonym: "4-aminobutyrate biosynthesis" EXACT [] +synonym: "4-aminobutyrate biosynthetic process" EXACT [] +synonym: "GABA biosynthesis" EXACT [] +synonym: "GABA biosynthetic process" EXACT [] +synonym: "gamma-aminobutyric acid anabolism" EXACT [] +synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] +synonym: "gamma-aminobutyric acid formation" EXACT [] +synonym: "gamma-aminobutyric acid synthesis" EXACT [] +is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process +is_a: GO:0046358 ! butyrate biosynthetic process + +[Term] +id: GO:0009450 +name: gamma-aminobutyric acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] +comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. +subset: gosubset_prok +synonym: "4-aminobutanoate catabolic process" EXACT [] +synonym: "4-aminobutanoate catabolism" EXACT [] +synonym: "4-aminobutyrate catabolic process" EXACT [] +synonym: "4-aminobutyrate catabolism" EXACT [] +synonym: "GABA catabolic process" EXACT [] +synonym: "GABA catabolism" EXACT [] +synonym: "gamma-aminobutyric acid breakdown" EXACT [] +synonym: "gamma-aminobutyric acid catabolism" EXACT [] +synonym: "gamma-aminobutyric acid degradation" EXACT [] +xref: MetaCyc:4AMINOBUTMETAB-PWY +xref: MetaCyc:4AMINOBUTMETAB2-PWY +is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process +is_a: GO:0046359 ! butyrate catabolic process + +[Term] +id: GO:0009451 +name: RNA modification +namespace: biological_process +alt_id: GO:0016547 +def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337 "Modification and Editing of RNA"] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. +subset: gosubset_prok +synonym: "RNA editing" EXACT [] +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0043412 ! biopolymer modification + +[Term] +id: GO:0009452 +name: RNA capping +namespace: biological_process +def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript." [PMID:9266685] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0009453 +name: energy taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] +subset: gosubset_prok +synonym: "energytaxis" EXACT [] +synonym: "taxis in response to energy source" EXACT [] +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0009454 +name: aerotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "taxis in response to atmospheric oxygen" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0009455 +name: redox taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423] +synonym: "redoxtaxis" EXACT [] +synonym: "taxis in response to redox potential" EXACT [] +synonym: "taxis in response to redox stimulus" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0009453 ! energy taxis +is_a: GO:0051775 ! response to redox state + +[Term] +id: GO:0009457 +name: flavodoxin +namespace: molecular_function +def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009458 +name: cytochrome +namespace: molecular_function +def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0045153 +consider: GO:0045154 +consider: GO:0045155 +consider: GO:0045156 +consider: GO:0045157 +consider: GO:0045158 + +[Term] +id: GO:0009459 +name: cytochrome a +namespace: molecular_function +def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045154 + +[Term] +id: GO:0009460 +name: cytochrome b +namespace: molecular_function +def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009461 +name: cytochrome c +namespace: molecular_function +def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045155 + +[Term] +id: GO:0009462 +name: cytochrome d +namespace: molecular_function +def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009463 +name: cytochrome b/b6 +namespace: molecular_function +def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045158 + +[Term] +id: GO:0009464 +name: cytochrome b5 +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009465 +name: soluble cytochrome b562 +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045153 + +[Term] +id: GO:0009466 +name: class I cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009467 +name: monoheme class I cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009468 +name: diheme class I cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009469 +name: class II cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009470 +name: class IIa cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009471 +name: class III cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009472 +name: cytochrome c3 (tetraheme) +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009473 +name: cytochrome c7 (triheme) +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009474 +name: nonaheme cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009475 +name: high-molecular-weight cytochrome c (hexadecaheme) +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009476 +name: class IV cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009477 +name: cytochrome c1 +namespace: molecular_function +def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045153 + +[Term] +id: GO:0009478 +name: cytochrome c554 +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009479 +name: cytochrome f +namespace: molecular_function +def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045158 + +[Term] +id: GO:0009480 +name: class IIb cytochrome c +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009481 +name: aa3-type cytochrome c oxidase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009482 +name: ba3-type cytochrome c oxidase +namespace: molecular_function +alt_id: GO:0009484 +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009483 +name: caa3-type cytochrome c oxidase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009485 +name: cbb3-type cytochrome c oxidase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009486 +name: cytochrome bo3 ubiquinol oxidase activity +namespace: molecular_function +xref: EC:1.10.3.- +is_a: GO:0008827 ! cytochrome o ubiquinol oxidase activity + +[Term] +id: GO:0009487 +name: glutaredoxin +namespace: molecular_function +def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd] +comment: This term was made obsolete because it represent a gene product. +is_obsolete: true +consider: GO:0006467 +consider: GO:0015036 +consider: GO:0015038 + +[Term] +id: GO:0009488 +name: amicyanin +namespace: molecular_function +def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009489 +name: rubredoxin +namespace: molecular_function +def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009490 +name: mononuclear iron electron carrier +namespace: molecular_function +def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009491 +name: redox-active disulfide bond electron carrier +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "redox-active disulphide bond electron carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009492 +name: 2Fe-2S electron transfer carrier +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009493 +name: adrenodoxin-type ferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009494 +name: chloroplast-type ferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009495 +name: thioredoxin-like 2Fe-2S ferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009496 +name: plastoquinol-plastocyanin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin." [EC:1.10.99.1] +subset: gosubset_prok +synonym: "cytochrome b6f" NARROW [EC:1.10.99.1] +synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] +synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] +xref: EC:1.10.99.1 +xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0009497 +name: 3Fe-4S/4Fe-4S electron transfer carrier +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009498 +name: bacterial-type ferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009499 +name: monocluster bacterial-type ferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009500 +name: dicluster bacterial-type ferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009501 +name: amyloplast +namespace: cellular_component +def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009502 +name: photosynthetic electron transport chain +namespace: cellular_component +def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:014051403] +comment: This term was obsoleted because it represents a process. +is_obsolete: true +consider: GO:0009767 + +[Term] +id: GO:0009503 +name: thylakoid light-harvesting complex +namespace: cellular_component +def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. As in, but not restricted to, green plants and algae (Viridiplantae, ncbi_taxonomy_id:33090)." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "light-harvesting complex (sensu Viridiplantae)" EXACT [] +is_a: GO:0030076 ! light-harvesting complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009535 ! chloroplast thylakoid membrane + +[Term] +id: GO:0009504 +name: cell plate +namespace: cellular_component +def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009505 +name: plant-type cell wall +namespace: cellular_component +def: "A more or less rigid stucture enclosing the protoplast of a cell and composed of cellulose and pectin and other organic and inorganic substances. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [ISBN:0471245208] +synonym: "cell wall (sensu Magnoliophyta)" EXACT [] +synonym: "cellulose and pectin-containing cell wall" EXACT [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0009506 +name: plasmodesma +namespace: cellular_component +def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "plasmodesmata" EXACT [] +is_a: GO:0005911 ! cell-cell junction +relationship: part_of GO:0055044 ! symplast + +[Term] +id: GO:0009507 +name: chloroplast +namespace: cellular_component +def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009508 +name: plastid chromosome +namespace: cellular_component +def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999] +is_a: GO:0000229 ! cytoplasmic chromosome +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0042646 ! plastid nucleoid + +[Term] +id: GO:0009509 +name: chromoplast +namespace: cellular_component +def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009510 +name: plasmodesmatal desmotubule +namespace: cellular_component +alt_id: GO:0009572 +def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] +synonym: "desmotubule central rod" RELATED [] +is_a: GO:0044432 ! endoplasmic reticulum part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0009506 ! plasmodesma + +[Term] +id: GO:0009511 +name: plasmodesmatal endoplasmic reticulum +namespace: cellular_component +def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai] +synonym: "plasmodesmatal ER" EXACT [] +is_a: GO:0005783 ! endoplasmic reticulum +is_a: GO:0044432 ! endoplasmic reticulum part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0009510 ! plasmodesmatal desmotubule + +[Term] +id: GO:0009512 +name: cytochrome b6f complex +namespace: cellular_component +def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458] +subset: gosubset_prok +synonym: "cyt b(6)f complex" EXACT [] +synonym: "cyt b6-f complex" EXACT [] +synonym: "cyt b6/f complex" EXACT [] +synonym: "cyt b6f complex" EXACT [] +synonym: "cytochrome b(6)f complex" EXACT [] +synonym: "cytochrome b6-f complex" EXACT [] +synonym: "cytochrome b6/f complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044436 ! thylakoid part + +[Term] +id: GO:0009513 +name: etioplast +namespace: cellular_component +def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009514 +name: glyoxysome +namespace: cellular_component +def: "A microbody that contains the enzymes of the glyoxylate pathway." [ISBN:0140514031] +is_a: GO:0042579 ! microbody + +[Term] +id: GO:0009515 +name: granal stacked thylakoid +namespace: cellular_component +def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] +synonym: "chloroplast stacked thylakoid" EXACT [] +is_a: GO:0009534 ! chloroplast thylakoid +relationship: part_of GO:0009542 ! granum + +[Term] +id: GO:0009516 +name: leucoplast +namespace: cellular_component +def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009517 +name: PSII associated light-harvesting complex II +namespace: cellular_component +def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] +synonym: "LHCII" EXACT [] +is_a: GO:0009503 ! thylakoid light-harvesting complex + +[Term] +id: GO:0009518 +name: PSI associated light-harvesting complex I +namespace: cellular_component +def: "Protein-pigment complex associated with photosystem I." [GOC:lr] +synonym: "LHCI" EXACT [] +is_a: GO:0009503 ! thylakoid light-harvesting complex + +[Term] +id: GO:0009519 +name: middle lamella +namespace: cellular_component +def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0009521 +name: photosystem +namespace: cellular_component +alt_id: GO:0030090 +def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] +subset: goslim_pir +subset: gosubset_prok +synonym: "reaction center (sensu Gram-negative Bacteria)" NARROW [] +synonym: "reaction center (sensu Proteobacteria)" NARROW [] +synonym: "reaction centre (sensu Gram-negative Bacteria)" NARROW [] +synonym: "reaction centre (sensu Proteobacteria)" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0034357 ! photosynthetic membrane + +[Term] +id: GO:0009522 +name: photosystem I +namespace: cellular_component +def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] +subset: gosubset_prok +is_a: GO:0009521 ! photosystem + +[Term] +id: GO:0009523 +name: photosystem II +namespace: cellular_component +def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] +subset: gosubset_prok +is_a: GO:0009521 ! photosystem + +[Term] +id: GO:0009524 +name: phragmoplast +namespace: cellular_component +def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009525 +name: phragmosome +namespace: cellular_component +def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009526 +name: plastid envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] +is_a: GO:0031967 ! organelle envelope +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0009527 +name: plastid outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] +is_a: GO:0031968 ! organelle outer membrane +is_a: GO:0042170 ! plastid membrane + +[Term] +id: GO:0009528 +name: plastid inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] +is_a: GO:0019866 ! organelle inner membrane +is_a: GO:0042170 ! plastid membrane + +[Term] +id: GO:0009529 +name: plastid intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] +synonym: "plastid envelope lumen" EXACT [] +is_a: GO:0031970 ! organelle envelope lumen +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009526 ! plastid envelope + +[Term] +id: GO:0009530 +name: primary cell wall +namespace: cellular_component +def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0009505 ! plant-type cell wall +is_a: GO:0048196 ! middle lamella-containing extracellular matrix + +[Term] +id: GO:0009531 +name: secondary cell wall +namespace: cellular_component +def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0009505 ! plant-type cell wall +is_a: GO:0048196 ! middle lamella-containing extracellular matrix + +[Term] +id: GO:0009532 +name: plastid stroma +namespace: cellular_component +def: "The proteinaceous ground substance of plastids." [ISBN:047142520] +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0009533 +name: chloroplast stromal thylakoid +namespace: cellular_component +def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999] +is_a: GO:0009534 ! chloroplast thylakoid +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0009534 +name: chloroplast thylakoid +namespace: cellular_component +def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana." [GOC:mtg_sensu, ISBN:0943883999] +synonym: "thylakoid (sensu Viridiplantae)" EXACT [] +is_a: GO:0031976 ! plastid thylakoid +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0009535 +name: chloroplast thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of a chloroplast thylakoid." [GOC:lr, GOC:mtg_sensu] +synonym: "thylakoid membrane (sensu Viridiplantae)" EXACT [] +is_a: GO:0044434 ! chloroplast part +is_a: GO:0055035 ! plastid thylakoid membrane +relationship: part_of GO:0009534 ! chloroplast thylakoid + +[Term] +id: GO:0009536 +name: plastid +namespace: cellular_component +def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009537 +name: proplastid +namespace: cellular_component +def: "The precursor of other plastids." [ISBN:0943883999] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009538 +name: photosystem I reaction center +namespace: cellular_component +def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] +subset: gosubset_prok +synonym: "photosystem I reaction centre" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0009522 ! photosystem I + +[Term] +id: GO:0009539 +name: photosystem II reaction center +namespace: cellular_component +def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] +subset: gosubset_prok +synonym: "photosystem II reaction centre" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0009523 ! photosystem II + +[Term] +id: GO:0009540 +name: zeaxanthin epoxidase activity +namespace: molecular_function +def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] +synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90] +synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] +xref: EC:1.14.13.90 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0009541 +name: etioplast prolamellar body +namespace: cellular_component +def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0009542 +name: granum +namespace: cellular_component +def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403] +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0009543 +name: chloroplast thylakoid lumen +namespace: cellular_component +def: "The cavity enclosed within the chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:006501037] +synonym: "thylakoid lumen (sensu Viridiplantae)" EXACT [] +is_a: GO:0031978 ! plastid thylakoid lumen +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009534 ! chloroplast thylakoid + +[Term] +id: GO:0009544 +name: chloroplast ATP synthase complex +namespace: cellular_component +def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009535 ! chloroplast thylakoid membrane + +[Term] +id: GO:0009545 +name: elaioplast +namespace: cellular_component +def: "A leucoplast in which oil is stored." [ISBN:0140514031] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009546 +name: plasmodesmatal cytoplasmic sleeve +namespace: cellular_component +def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] +synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0009506 ! plasmodesma + +[Term] +id: GO:0009547 +name: plastid ribosome +namespace: cellular_component +def: "A ribosome contained within a plastid." [GOC:tair_curators] +is_a: GO:0000313 ! organellar ribosome +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009532 ! plastid stroma + +[Term] +id: GO:0009548 +name: plasmodesmatal plasma membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0009506 ! plasmodesma + +[Term] +id: GO:0009549 +name: cellulose microfibril +namespace: cellular_component +def: "Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the protoplast." [GOC:jic, http://cancerweb.ncl.ac.uk, ISBN:0943088399] +is_a: GO:0001527 ! microfibril +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009530 ! primary cell wall +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0009550 +name: primary plasmodesma +namespace: cellular_component +def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] +synonym: "simple plasmodesma" EXACT [] +is_a: GO:0009506 ! plasmodesma + +[Term] +id: GO:0009551 +name: secondary plasmodesma +namespace: cellular_component +def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] +is_a: GO:0009506 ! plasmodesma + +[Term] +id: GO:0009553 +name: embryo sac development +namespace: biological_process +alt_id: GO:0048230 +def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb] +synonym: "female gametophyte development" EXACT [] +is_a: GO:0048229 ! gametophyte development + +[Term] +id: GO:0009554 +name: megasporogenesis +namespace: biological_process +def: "The process by which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] +synonym: "megaspore development" EXACT [] +synonym: "megaspore mother cell meiosis" EXACT [] +synonym: "meiosis of the megasporocyte" EXACT [] +synonym: "meiotic division of the megasporocyte" EXACT [] +is_a: GO:0048236 ! plant-type spore development +relationship: part_of GO:0009553 ! embryo sac development + +[Term] +id: GO:0009555 +name: pollen development +namespace: biological_process +alt_id: GO:0009564 +alt_id: GO:0048231 +def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb] +synonym: "formation of generative and vegetative cells" EXACT [] +synonym: "male gametophyte development" EXACT [] +synonym: "male gametophyte formation" EXACT [] +synonym: "microgametophyte development" EXACT [] +synonym: "pollen grain formation" EXACT [] +is_a: GO:0048229 ! gametophyte development + +[Term] +id: GO:0009556 +name: microsporogenesis +namespace: biological_process +def: "The process by which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] +synonym: "microspore development" EXACT systematic_synonym [] +is_a: GO:0048236 ! plant-type spore development +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0009557 +name: antipodal cell differentiation +namespace: biological_process +def: "The process whereby an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jic, GOC:mtg_plant] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009558 +name: cellularization of the embryo sac +namespace: biological_process +alt_id: GO:0009797 +def: "The process by which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jic, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X] +synonym: "cellularization (sensu Magnoliophyta)" EXACT [] +synonym: "cellularization of megagametophyte" EXACT [] +synonym: "cellularization of the female gametophyte" EXACT [] +is_a: GO:0007349 ! cellularization +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009559 +name: embryo sac central cell differentiation +namespace: biological_process +def: "The process whereby the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jic, GOC:mtg_plant] +synonym: "embryo sac endosperm mother cell differentiation" EXACT [] +synonym: "female gametophyte central cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009560 +name: embryo sac egg cell differentiation +namespace: biological_process +alt_id: GO:0048233 +def: "The process whereby an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell." [GOC:jic, GOC:mtg_plant, GOC:mtg_sensu] +synonym: "female gamete generation (sensu Magnoliophyta)" EXACT [] +synonym: "female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0007292 ! female gamete generation +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009561 +name: megagametogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant] +synonym: "embryo sac development from the megaspore" EXACT systematic_synonym [] +synonym: "megagametophyte nucleus division" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009553 ! embryo sac development + +[Term] +id: GO:0009562 +name: embryo sac nuclear migration +namespace: biological_process +def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant] +synonym: "embryo sac nucleus migration" EXACT [] +synonym: "female gametophyte nuclear migration" EXACT [] +synonym: "female gametophyte nucleus migration" EXACT [] +synonym: "megagametophyte nuclear migration" EXACT [] +synonym: "megagametophyte nucleus migration" EXACT [] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009563 +name: synergid differentiation +namespace: biological_process +def: "The process whereby an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jic] +synonym: "synergid cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009566 +name: fertilization +namespace: biological_process +def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0009567 +name: double fertilization forming a zygote and endosperm +namespace: biological_process +def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved." [GOC:mtg_sensu, GOC:tb] +synonym: "double fertilization (sensu Magnoliophyta)" EXACT [] +is_a: GO:0009566 ! fertilization + +[Term] +id: GO:0009568 +name: amyloplast starch grain +namespace: cellular_component +def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] +synonym: "amyloplast starch granule" EXACT [] +is_a: GO:0043036 ! starch grain +relationship: part_of GO:0009501 ! amyloplast + +[Term] +id: GO:0009569 +name: chloroplast starch grain +namespace: cellular_component +def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "chloroplast starch granule" EXACT [] +is_a: GO:0043036 ! starch grain +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0009570 +name: chloroplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] +is_a: GO:0009532 ! plastid stroma +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0009571 +name: proplastid stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009537 ! proplastid + +[Term] +id: GO:0009573 +name: chloroplast ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] +synonym: "ribulose bisphosphate carboxylase complex (sensu Magnoliophyta)" EXACT [] +synonym: "RubisCO complex (sensu Magnoliophyta)" EXACT [] +is_a: GO:0044434 ! chloroplast part +is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0009574 +name: preprophase band +namespace: cellular_component +def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0009575 +name: chromoplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009509 ! chromoplast + +[Term] +id: GO:0009576 +name: leucoplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009516 ! leucoplast + +[Term] +id: GO:0009577 +name: elaioplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009545 ! elaioplast + +[Term] +id: GO:0009578 +name: etioplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0009579 +name: thylakoid +namespace: cellular_component +def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "photosynthetic membrane" RELATED [] +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0009580 +name: thylakoid (sensu Bacteria) +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific children exist. +is_obsolete: true +consider: GO:0030075 +consider: GO:0042716 + +[Term] +id: GO:0009581 +name: detection of external stimulus +namespace: biological_process +def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +subset: gosubset_prok +synonym: "perception of external stimulus" RELATED [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009582 +name: detection of abiotic stimulus +namespace: biological_process +def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +subset: gosubset_prok +synonym: "perception of abiotic stimulus" RELATED [] +is_a: GO:0009628 ! response to abiotic stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009583 +name: detection of light stimulus +namespace: biological_process +def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] +subset: gosubset_prok +synonym: "detection of light" EXACT [] +synonym: "perception of light" RELATED [] +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0009584 +name: detection of visible light +namespace: biological_process +def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "perception of visible light" RELATED [] +is_a: GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0009585 +name: red, far-red light phototransduction +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah] +subset: gosubset_prok +synonym: "phytochrome signaling pathway" BROAD [] +synonym: "red-sensitive opsin" RELATED [] +is_a: GO:0007602 ! phototransduction + +[Term] +id: GO:0009586 +name: rhodopsin mediated phototransduction +namespace: biological_process +def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events then required to return the rhodopsin containing cell to the unexcited state." [GOC:hb] +is_a: GO:0007602 ! phototransduction + +[Term] +id: GO:0009587 +name: phototrophin mediated phototransduction +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +is_obsolete: true +replaced_by: GO:0007602 + +[Term] +id: GO:0009588 +name: UV-A, blue light phototransduction +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of approximately 400-500 nm." [GOC:mah] +synonym: "blue-sensitive opsin" RELATED [] +synonym: "short-wave-sensitive opsin" RELATED [] +synonym: "violet-sensitive opsin" RELATED [] +is_a: GO:0007602 ! phototransduction + +[Term] +id: GO:0009589 +name: detection of UV +namespace: biological_process +def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received by a cell and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "detection of ultraviolet light stimulus" EXACT [] +synonym: "detection of ultraviolet radiation stimulus" EXACT [] +synonym: "detection of UV light stimulus" EXACT [] +synonym: "detection of UV radiation stimulus" EXACT [] +synonym: "perception of UV" RELATED [] +is_a: GO:0009411 ! response to UV +is_a: GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0009590 +name: detection of gravity +namespace: biological_process +def: "The series of events in which a gravitational stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +synonym: "perception of gravity" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus +is_a: GO:0009629 ! response to gravity + +[Term] +id: GO:0009591 +name: perception of mechanical stimulus +namespace: biological_process +alt_id: GO:0007609 +def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. +is_obsolete: true +consider: GO:0050954 + +[Term] +id: GO:0009593 +name: detection of chemical stimulus +namespace: biological_process +def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] +synonym: "chemoperception" EXACT [] +synonym: "detection of chemical substance" EXACT [] +synonym: "perception of chemical stimulus" RELATED [] +synonym: "perception of chemical substance" RELATED [] +is_a: GO:0042221 ! response to chemical stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009594 +name: detection of nutrient +namespace: biological_process +def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] +synonym: "detection of nutrients" EXACT [] +synonym: "nutrient sensing" RELATED [] +synonym: "perception of nutrients" RELATED [] +is_a: GO:0007584 ! response to nutrient +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0009595 +name: detection of biotic stimulus +namespace: biological_process +alt_id: GO:0009596 +def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] +subset: gosubset_prok +synonym: "perception of biotic stimulus" RELATED [] +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009597 +name: detection of virus +namespace: biological_process +def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] +subset: gosubset_prok +synonym: "perception of virus" RELATED [] +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009615 ! response to virus + +[Term] +id: GO:0009600 +name: detection of nematode +namespace: biological_process +def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb] +synonym: "perception of nematode" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009624 ! response to nematode + +[Term] +id: GO:0009601 +name: detection of insect +namespace: biological_process +def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb] +synonym: "perception of insect" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009625 ! response to insect + +[Term] +id: GO:0009602 +name: detection of symbiont +namespace: biological_process +def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "perception of symbiont" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009608 ! response to symbiont + +[Term] +id: GO:0009603 +name: detection of symbiotic fungus +namespace: biological_process +def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "detection of symbiotic fungi" EXACT [] +synonym: "perception of symbiotic fungi" RELATED [] +synonym: "perception of symbiotic fungus" RELATED [] +is_a: GO:0009602 ! detection of symbiont +is_a: GO:0009610 ! response to symbiotic fungus +is_a: GO:0016046 ! detection of fungus + +[Term] +id: GO:0009604 +name: detection of symbiotic bacterium +namespace: biological_process +def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "detection of symbiotic bacteria" EXACT [] +synonym: "perception of symbiotic bacteria" RELATED [] +synonym: "perception of symbiotic bacterium" RELATED [] +is_a: GO:0009602 ! detection of symbiont +is_a: GO:0009609 ! response to symbiotic bacterium +is_a: GO:0016045 ! detection of bacterium + +[Term] +id: GO:0009605 +name: response to external stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +synonym: "response to environmental stimulus" EXACT [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009606 +name: tropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: goslim_plant +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0009607 +name: response to biotic stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +synonym: "response to biotic stress" NARROW [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009608 +name: response to symbiont +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "response of host to symbiont" RELATED [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009609 +name: response to symbiotic bacterium +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "response to symbiotic bacteria" EXACT [] +is_a: GO:0009608 ! response to symbiont +is_a: GO:0009617 ! response to bacterium + +[Term] +id: GO:0009610 +name: response to symbiotic fungus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "response to symbiotic fungi" EXACT [] +is_a: GO:0009608 ! response to symbiont +is_a: GO:0009620 ! response to fungus + +[Term] +id: GO:0009611 +name: response to wounding +namespace: biological_process +alt_id: GO:0002245 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] +synonym: "physiological response to wounding" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0009612 +name: response to mechanical stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] +subset: gosubset_prok +synonym: "chemi-mechanical coupling" RELATED [] +synonym: "mechanical stimulus response" EXACT [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009614 +name: disease resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0051707 + +[Term] +id: GO:0009615 +name: response to virus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] +subset: gosubset_prok +synonym: "response to viruses" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009616 +name: virus induced gene silencing +namespace: biological_process +def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl] +synonym: "VIGS" EXACT [] +synonym: "virus-induced gene silencing" EXACT [] +is_a: GO:0045087 ! innate immune response +is_a: GO:0051607 ! defense response to virus +is_a: GO:0052018 ! modulation by symbiont of host RNA levels + +[Term] +id: GO:0009617 +name: response to bacterium +namespace: biological_process +alt_id: GO:0009618 +alt_id: GO:0009680 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] +subset: gosubset_prok +synonym: "response to bacteria" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009619 +name: resistance to pathogenic bacteria +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0009617 + +[Term] +id: GO:0009620 +name: response to fungus +namespace: biological_process +alt_id: GO:0009621 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] +synonym: "response to fungi" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009622 +name: resistance to pathogenic fungi +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0009620 + +[Term] +id: GO:0009623 +name: response to parasitic fungus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "response to parasitic fungi" EXACT [] +is_a: GO:0009610 ! response to symbiotic fungus + +[Term] +id: GO:0009624 +name: response to nematode +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb] +synonym: "response to nematodes" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009625 +name: response to insect +namespace: biological_process +alt_id: GO:0043019 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb] +synonym: "response to insects" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009626 +name: plant-type hypersensitive response +namespace: biological_process +def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] +comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. +synonym: "HR" EXACT [] +synonym: "HR-PCD" EXACT [] +synonym: "plant hypersensitive response" EXACT [] +is_a: GO:0034050 ! host programmed cell death induced by symbiont +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0009627 +name: systemic acquired resistance +namespace: biological_process +def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:052143641] +synonym: "salicylic acid-dependent systemic resistance" EXACT [] +is_a: GO:0009814 ! defense response, incompatible interaction + +[Term] +id: GO:0009628 +name: response to abiotic stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +synonym: "response to abiotic stress" NARROW [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009629 +name: response to gravity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] +synonym: "response to gravitational stimulus" EXACT [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009630 +name: gravitropism +namespace: biological_process +def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684] +synonym: "geotropism" EXACT [] +is_a: GO:0009606 ! tropism +is_a: GO:0009629 ! response to gravity + +[Term] +id: GO:0009631 +name: cold acclimation +namespace: biological_process +def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] +subset: gosubset_prok +is_a: GO:0009409 ! response to cold + +[Term] +id: GO:0009632 +name: freezing tolerance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. +is_obsolete: true +consider: GO:0009409 + +[Term] +id: GO:0009633 +name: drought tolerance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. +is_obsolete: true +consider: GO:0009414 +consider: GO:0009819 + +[Term] +id: GO:0009634 +name: heavy metal sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +consider: GO:0010038 + +[Term] +id: GO:0009635 +name: response to herbicide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "herbicide susceptibility/resistance" RELATED [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0009636 +name: response to toxin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus." [GOC:lr] +subset: gosubset_prok +synonym: "detoxification response" NARROW [] +synonym: "toxin resistance" RELATED [] +synonym: "toxin susceptibility/resistance" RELATED [] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0009637 +name: response to blue light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] +synonym: "response to blue light stimulus" EXACT [] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009638 +name: phototropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, http://cancerweb.ncl.ac.uk/] +is_a: GO:0009606 ! tropism +is_a: GO:0009637 ! response to blue light + +[Term] +id: GO:0009639 +name: response to red or far red light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009640 +name: photomorphogenesis +namespace: biological_process +def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr] +synonym: "plant development in response to light" EXACT systematic_synonym [] +is_a: GO:0009639 ! response to red or far red light +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0009641 +name: shade avoidance +namespace: biological_process +def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [http://en.wikipedia.org "Wikipedia"] +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0009642 +name: response to light intensity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009643 +name: photosynthetic acclimation +namespace: biological_process +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009644 +name: response to high light intensity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009645 +name: response to low light intensity stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009646 +name: response to absence of light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009647 +name: skotomorphogenesis +namespace: biological_process +def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288] +synonym: "etiolation" RELATED [] +is_a: GO:0009646 ! response to absence of light +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0009648 +name: photoperiodism +namespace: biological_process +def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "response to day length" EXACT [] +synonym: "response to night length" EXACT [] +synonym: "response to photoperiod" EXACT [] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009649 +name: entrainment of circadian clock +namespace: biological_process +def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jic] +is_a: GO:0009605 ! response to external stimulus +relationship: part_of GO:0007623 ! circadian rhythm + +[Term] +id: GO:0009650 +name: UV protection +namespace: biological_process +def: "Any process by which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] +subset: gosubset_prok +synonym: "ultraviolet protection" EXACT [] +synonym: "ultraviolet resistance" RELATED [] +synonym: "ultraviolet tolerance" RELATED [] +synonym: "UV resistance" RELATED [] +synonym: "UV tolerance" RELATED [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0009651 +name: response to salt stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] +subset: gosubset_prok +synonym: "esponse to ionic osmotic stress" EXACT [] +synonym: "salinity response" EXACT [] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0009652 +name: thigmotropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0009606 ! tropism +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0009653 +name: anatomical structure morphogenesis +namespace: biological_process +def: "The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "anatomical structure organization" EXACT [] +synonym: "embryogenesis and morphogenesis" BROAD [] +synonym: "morphogenesis" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0048856 ! anatomical structure development + +[Term] +id: GO:0009654 +name: oxygen evolving complex +namespace: cellular_component +def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [InterPro:IPR002683] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009523 ! photosystem II + +[Term] +id: GO:0009655 +name: PSII associated light-harvesting complex II, core complex +namespace: cellular_component +def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] +subset: gosubset_prok +synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] +synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] +synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II + +[Term] +id: GO:0009656 +name: PSII associated light-harvesting complex II, peripheral complex +namespace: cellular_component +def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II + +[Term] +id: GO:0009657 +name: plastid organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] +subset: goslim_pir +synonym: "plastid organisation and biogenesis" EXACT [] +synonym: "plastid organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0009658 +name: chloroplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jic] +synonym: "chloroplast organisation and biogenesis" EXACT [] +synonym: "chloroplast organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009659 +name: leucoplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jic] +synonym: "leucoplast organisation and biogenesis" EXACT [] +synonym: "leucoplast organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009660 +name: amyloplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jic] +synonym: "amyloplast organisation and biogenesis" EXACT [] +synonym: "amyloplast organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009661 +name: chromoplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jic] +synonym: "chromoplast organisation and biogenesis" EXACT [] +synonym: "chromoplast organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009662 +name: etioplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jic] +synonym: "etioplast organisation and biogenesis" EXACT [] +synonym: "etioplast organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009663 +name: plasmodesma organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah] +synonym: "plasmodesma organisation and biogenesis" EXACT [] +synonym: "plasmodesma organization and biogenesis" RELATED [] +synonym: "plasmodesmata organization and biogenesis" EXACT [] +is_a: GO:0007028 ! cytoplasm organization + +[Term] +id: GO:0009664 +name: plant-type cell wall organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cellulose and pectin-containing cell wall; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:jic, GOC:mtg_sensu] +synonym: "cell wall organisation and biogenesis (sensu Magnoliophyta)" EXACT [] +synonym: "cell wall organization and biogenesis (sensu Magnoliophyta)" EXACT [] +synonym: "cellulose and pectin-containing cell wall organization and biogenesis" EXACT [] +synonym: "plant-type cell wall organization and biogenesis" EXACT [] +is_a: GO:0007047 ! cell wall organization + +[Term] +id: GO:0009665 +name: plastid inheritance +namespace: biological_process +def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009666 +name: plastid outer membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "plastid outer membrane organisation and biogenesis" EXACT [] +synonym: "plastid outer membrane organization and biogenesis" EXACT [] +is_a: GO:0009668 ! plastid membrane organization + +[Term] +id: GO:0009667 +name: plastid inner membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "plastid inner membrane organisation and biogenesis" EXACT [] +synonym: "plastid inner membrane organization and biogenesis" EXACT [] +is_a: GO:0009668 ! plastid membrane organization + +[Term] +id: GO:0009668 +name: plastid membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "plastid membrane organisation and biogenesis" EXACT [] +synonym: "plastid membrane organization and biogenesis" EXACT [] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0009657 ! plastid organization + +[Term] +id: GO:0009669 +name: sucrose:monovalent cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] +synonym: "sucrose permease activity" RELATED [] +is_a: GO:0008515 ! sucrose transmembrane transporter activity +is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity + +[Term] +id: GO:0009670 +name: triose-phosphate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015122 +def: "Enables the exchange of an organic three carbon compound phosphate ester for inorganic phosphate." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] +synonym: "triose phosphate transporter" EXACT [] +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0009671 +name: nitrate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [UniProtKB:Q05085] +synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] +synonym: "nitrate(chlorate):proton symporter" EXACT [] +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0009672 +name: auxin:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] +synonym: "auxin:proton symporter" EXACT [] +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0009673 +name: low affinity phosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] +is_a: GO:0015114 ! phosphate transmembrane transporter activity + +[Term] +id: GO:0009674 +name: potassium:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] +synonym: "high affinity potassium transporter" RELATED [] +is_a: GO:0022820 ! potassium ion symporter activity + +[Term] +id: GO:0009675 +name: high affinity sulfate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). Transporter with a high affinity for sulfate, that mediates the active uptake of sulfate from areas of low sulfate concentration to high sulfate concentration." [UniProtKB:P53391] +synonym: "high affinity sulfate:proton symporter" EXACT [] +synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] +is_a: GO:0008512 ! sulfate:hydrogen symporter activity + +[Term] +id: GO:0009676 +name: low affinity sulfate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). Transporter that mediates the transport of sulfate between cellular or subcellular compartments with a low affinity for hydrogen and sulfate." [PMID:7568135] +synonym: "low affinity sulfate:proton symporter" EXACT [] +synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] +is_a: GO:0008512 ! sulfate:hydrogen symporter activity + +[Term] +id: GO:0009677 +name: double fertilization forming two zygotes +namespace: biological_process +def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates." [GOC:mtg_sensu, GOC:tb] +synonym: "double fertilization (sensu Gnetophyta)" EXACT [] +is_a: GO:0009566 ! fertilization + +[Term] +id: GO:0009678 +name: hydrogen-translocating pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-] +subset: gosubset_prok +synonym: "proton-translocating pyrophosphatase activity" EXACT [] +is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0009679 +name: hexose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] +subset: gosubset_prok +synonym: "hexose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0009682 +name: induced systemic resistance +namespace: biological_process +def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] +is_a: GO:0042742 ! defense response to bacterium +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0009683 +name: indoleacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah] +subset: gosubset_prok +synonym: "IAA metabolic process" EXACT [] +synonym: "indole acetic acid metabolic process" EXACT [] +synonym: "indole acetic acid metabolism" EXACT [] +synonym: "indoleacetic acid metabolism" EXACT [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042434 ! indole derivative metabolic process + +[Term] +id: GO:0009684 +name: indoleacetic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] +subset: gosubset_prok +synonym: "IAA biosynthetic process" EXACT [] +synonym: "indole acetic acid biosynthesis" EXACT [] +synonym: "indole acetic acid biosynthetic process" EXACT [] +synonym: "indole-3-acetate biosynthesis" EXACT [] +synonym: "indole-3-acetate biosynthetic process" EXACT [] +synonym: "indole-acetic acid biosynthesis" EXACT [] +synonym: "indole-acetic acid biosynthetic process" RELATED [] +synonym: "indoleacetic acid anabolism" EXACT [] +synonym: "indoleacetic acid biosynthesis" EXACT [] +synonym: "indoleacetic acid formation" EXACT [] +synonym: "indoleacetic acid synthesis" EXACT [] +is_a: GO:0009683 ! indoleacetic acid metabolic process +is_a: GO:0009851 ! auxin biosynthetic process +is_a: GO:0042435 ! indole derivative biosynthetic process + +[Term] +id: GO:0009685 +name: gibberellin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] +subset: gosubset_prok +synonym: "gibberellic acid metabolic process" NARROW [] +synonym: "gibberellic acid metabolism" NARROW [] +synonym: "gibberellin metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009686 +name: gibberellin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] +subset: gosubset_prok +synonym: "gibberellic acid anabolism" NARROW [] +synonym: "gibberellic acid biosynthesis" NARROW [] +synonym: "gibberellic acid biosynthetic process" NARROW [] +synonym: "gibberellic acid formation" NARROW [] +synonym: "gibberellic acid synthesis" NARROW [] +synonym: "gibberellin biosynthesis" EXACT [] +xref: MetaCyc:PWY-5035 +xref: MetaCyc:PWY-5036 +xref: MetaCyc:PWY-5052 +xref: MetaCyc:PWY-5070 +is_a: GO:0009685 ! gibberellin metabolic process +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0009687 +name: abscisic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] +subset: gosubset_prok +synonym: "abscisic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043288 ! apocarotenoid metabolic process + +[Term] +id: GO:0009688 +name: abscisic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] +subset: gosubset_prok +synonym: "abscisic acid anabolism" EXACT [] +synonym: "abscisic acid biosynthesis" EXACT [] +synonym: "abscisic acid formation" EXACT [] +synonym: "abscisic acid synthesis" EXACT [] +xref: MetaCyc:PWY-695 +is_a: GO:0009687 ! abscisic acid metabolic process +is_a: GO:0043289 ! apocarotenoid biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0009689 +name: induction of phytoalexin biosynthetic process +namespace: biological_process +def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399] +synonym: "induction of phytoalexin anabolism" EXACT [] +synonym: "induction of phytoalexin biosynthesis" EXACT [] +synonym: "induction of phytoalexin formation" EXACT [] +synonym: "induction of phytoalexin synthesis" EXACT [] +is_a: GO:0009814 ! defense response, incompatible interaction +is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process + +[Term] +id: GO:0009690 +name: cytokinin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] +subset: gosubset_prok +synonym: "cytokinin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0009691 +name: cytokinin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] +subset: gosubset_prok +synonym: "cytokinin anabolism" EXACT [] +synonym: "cytokinin biosynthesis" EXACT [] +synonym: "cytokinin formation" EXACT [] +synonym: "cytokinin synthesis" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0009692 +name: ethylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] +subset: gosubset_prok +synonym: "ethene metabolic process" EXACT [] +synonym: "ethene metabolism" EXACT [] +synonym: "ethylene metabolism" EXACT [] +xref: Reactome:76472 +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0009693 +name: ethylene biosynthetic process +namespace: biological_process +alt_id: GO:0042456 +def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] +subset: gosubset_prok +synonym: "ethene biosynthesis" EXACT [] +synonym: "ethene biosynthesis from L-methionine" EXACT [] +synonym: "ethene biosynthetic process" EXACT [] +synonym: "ethene biosynthetic process from L-methionine" EXACT [] +synonym: "ethylene anabolism" EXACT [] +synonym: "ethylene biosynthesis" EXACT [] +synonym: "ethylene biosynthesis from L-methionine" EXACT [] +synonym: "ethylene biosynthetic process from L-methionine" EXACT [] +synonym: "ethylene formation" EXACT [] +synonym: "ethylene synthesis" EXACT [] +xref: MetaCyc:ETHYL-PWY +is_a: GO:0006555 ! methionine metabolic process +is_a: GO:0009692 ! ethylene metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0043450 ! alkene biosynthetic process + +[Term] +id: GO:0009694 +name: jasmonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] +subset: gosubset_prok +synonym: "jasmonic acid metabolism" EXACT [] +is_a: GO:0031407 ! oxylipin metabolic process + +[Term] +id: GO:0009695 +name: jasmonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] +synonym: "jasmonic acid anabolism" EXACT [] +synonym: "jasmonic acid biosynthesis" EXACT [] +synonym: "jasmonic acid formation" EXACT [] +synonym: "jasmonic acid synthesis" EXACT [] +xref: MetaCyc:PWY-735 +is_a: GO:0009694 ! jasmonic acid metabolic process +is_a: GO:0031408 ! oxylipin biosynthetic process +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0009696 +name: salicylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] +subset: gosubset_prok +synonym: "salicylic acid metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009697 +name: salicylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] +subset: gosubset_prok +synonym: "salicylate biosynthetic process" EXACT [] +synonym: "salicylic acid anabolism" EXACT [] +synonym: "salicylic acid biosynthesis" EXACT [] +synonym: "salicylic acid formation" EXACT [] +synonym: "salicylic acid synthesis" EXACT [] +xref: MetaCyc:PWY-981 +is_a: GO:0009696 ! salicylic acid metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process + +[Term] +id: GO:0009698 +name: phenylpropanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl] +subset: gosubset_prok +synonym: "phenylpropanoid metabolism" EXACT [] +xref: MetaCyc:PWY1F-467 +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0009699 +name: phenylpropanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl] +subset: gosubset_prok +synonym: "phenylpropanoid anabolism" EXACT [] +synonym: "phenylpropanoid biosynthesis" EXACT [] +synonym: "phenylpropanoid formation" EXACT [] +synonym: "phenylpropanoid synthesis" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0009700 +name: indole phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684] +synonym: "indole phytoalexin anabolism" EXACT [] +synonym: "indole phytoalexin biosynthesis" EXACT [] +synonym: "indole phytoalexin formation" EXACT [] +synonym: "indole phytoalexin synthesis" EXACT [] +is_a: GO:0042435 ! indole derivative biosynthetic process +is_a: GO:0046217 ! indole phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0009701 +name: isoflavonoid phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +synonym: "isoflavonoid phytoalexin anabolism" EXACT [] +synonym: "isoflavonoid phytoalexin biosynthesis" EXACT [] +synonym: "isoflavonoid phytoalexin formation" EXACT [] +synonym: "isoflavonoid phytoalexin synthesis" EXACT [] +is_a: GO:0009716 ! flavonoid phytoalexin biosynthetic process +is_a: GO:0009717 ! isoflavonoid biosynthetic process +is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0009702 +name: L-arabinokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.46] +synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] +synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46] +xref: EC:2.7.1.46 +xref: MetaCyc:L-ARABINOKINASE-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0009703 +name: nitrate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NO2- (nitrite) + NAD+ + H2O = NO3- (nitrate) + NADH + H+." [EC:1.7.1.1] +comment: Note that this function was formerly EC:1.6.6.1. +synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1] +synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1] +synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] +synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1] +synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1] +synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1] +synonym: "NADH:nitrate reductase activity" EXACT [] +synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1] +synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1] +synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1] +xref: EC:1.7.1.1 +xref: MetaCyc:NITRATE-REDUCTASE-(NADH)-RXN +is_a: GO:0008940 ! nitrate reductase activity +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0009704 +name: de-etiolation +namespace: biological_process +def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr] +is_a: GO:0009416 ! response to light stimulus +relationship: part_of GO:0009640 ! photomorphogenesis + +[Term] +id: GO:0009705 +name: plant-type vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell." [GOC:mtg_sensu, ISBN:0471245208] +synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] +synonym: "tonoplast" EXACT [] +synonym: "vacuolar membrane (sensu Magnoliophyta)" EXACT [] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0009706 +name: chloroplast inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] +synonym: "chloroplast inner envelope" EXACT [] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0031969 ! chloroplast membrane + +[Term] +id: GO:0009707 +name: chloroplast outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] +synonym: "chloroplast outer envelope" EXACT [] +is_a: GO:0009527 ! plastid outer membrane +is_a: GO:0031969 ! chloroplast membrane + +[Term] +id: GO:0009708 +name: benzyl isoquinoline alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "benzyl isoquinoline alkaloid anabolism" EXACT [] +synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT [] +synonym: "benzyl isoquinoline alkaloid formation" EXACT [] +synonym: "benzyl isoquinoline alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process + +[Term] +id: GO:0009709 +name: terpenoid indole alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] +subset: gosubset_prok +synonym: "terpenoid indole alkaloid anabolism" EXACT [] +synonym: "terpenoid indole alkaloid biosynthesis" EXACT [] +synonym: "terpenoid indole alkaloid formation" EXACT [] +synonym: "terpenoid indole alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0042434 ! indole derivative metabolic process +is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process + +[Term] +id: GO:0009710 +name: tropane alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tropane alkaloid anabolism" EXACT [] +synonym: "tropane alkaloid biosynthesis" EXACT [] +synonym: "tropane alkaloid formation" EXACT [] +synonym: "tropane alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0046448 ! tropane alkaloid metabolic process + +[Term] +id: GO:0009711 +name: purine alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] +subset: gosubset_prok +synonym: "purine alkaloid anabolism" EXACT [] +synonym: "purine alkaloid biosynthesis" EXACT [] +synonym: "purine alkaloid formation" EXACT [] +synonym: "purine alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0046446 ! purine alkaloid metabolic process + +[Term] +id: GO:0009712 +name: catechol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] +subset: gosubset_prok +synonym: "catechol metabolism" EXACT [] +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0009713 +name: catechol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +subset: gosubset_prok +synonym: "catechol anabolism" EXACT [] +synonym: "catechol biosynthesis" EXACT [] +synonym: "catechol formation" EXACT [] +synonym: "catechol synthesis" EXACT [] +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0009714 +name: chalcone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chalcone metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0009715 +name: chalcone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators] +subset: gosubset_prok +synonym: "chalcone anabolism" EXACT [] +synonym: "chalcone biosynthesis" EXACT [] +synonym: "chalcone formation" EXACT [] +synonym: "chalcone synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009714 ! chalcone metabolic process +is_a: GO:0042181 ! ketone biosynthetic process + +[Term] +id: GO:0009716 +name: flavonoid phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "flavonoid phytoalexin anabolism" EXACT [] +synonym: "flavonoid phytoalexin biosynthesis" EXACT [] +synonym: "flavonoid phytoalexin formation" EXACT [] +synonym: "flavonoid phytoalexin synthesis" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046285 ! flavonoid phytoalexin metabolic process + +[Term] +id: GO:0009717 +name: isoflavonoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] +subset: gosubset_prok +synonym: "isoflavonoid anabolism" EXACT [] +synonym: "isoflavonoid biosynthesis" EXACT [] +synonym: "isoflavonoid formation" EXACT [] +synonym: "isoflavonoid synthesis" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046287 ! isoflavonoid metabolic process + +[Term] +id: GO:0009718 +name: anthocyanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] +subset: gosubset_prok +synonym: "anthocyanin anabolism" EXACT [] +synonym: "anthocyanin biosynthesis" EXACT [] +synonym: "anthocyanin formation" EXACT [] +synonym: "anthocyanin synthesis" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0046283 ! anthocyanin metabolic process + +[Term] +id: GO:0009719 +name: response to endogenous stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009720 +name: detection of hormone stimulus +namespace: biological_process +def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of hormone stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009725 ! response to hormone stimulus +is_a: GO:0009726 ! detection of endogenous stimulus + +[Term] +id: GO:0009721 +name: detection of auxin stimulus +namespace: biological_process +def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of auxin stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009733 ! response to auxin stimulus + +[Term] +id: GO:0009722 +name: detection of cytokinin stimulus +namespace: biological_process +def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of cytokinin stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009735 ! response to cytokinin stimulus + +[Term] +id: GO:0009723 +name: response to ethylene stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl] +synonym: "response to ethene stimulus" EXACT [] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009724 +name: detection of abscisic acid stimulus +namespace: biological_process +def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of abscisic acid stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009737 ! response to abscisic acid stimulus + +[Term] +id: GO:0009725 +name: response to hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] +synonym: "growth regulator" RELATED [] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0009726 +name: detection of endogenous stimulus +namespace: biological_process +def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of endogenous stimulus" RELATED [] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009727 +name: detection of ethylene stimulus +namespace: biological_process +def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "detection of ethene stimulus" EXACT [] +synonym: "perception of ethene stimulus" RELATED [] +synonym: "perception of ethylene stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009723 ! response to ethylene stimulus + +[Term] +id: GO:0009728 +name: detection of gibberellic acid stimulus +namespace: biological_process +def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of gibberellic acid stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009739 ! response to gibberellin stimulus + +[Term] +id: GO:0009729 +name: detection of brassinosteroid stimulus +namespace: biological_process +def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of brassinosteroid stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009741 ! response to brassinosteroid stimulus + +[Term] +id: GO:0009730 +name: detection of carbohydrate stimulus +namespace: biological_process +def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of carbohydrate stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0009731 +name: detection of sucrose stimulus +namespace: biological_process +def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of sucrose stimulus" RELATED [] +is_a: GO:0009744 ! response to sucrose stimulus +is_a: GO:0034288 ! detection of disaccharide stimulus + +[Term] +id: GO:0009732 +name: detection of hexose stimulus +namespace: biological_process +def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm] +synonym: "perception of hexose stimulus" RELATED [] +is_a: GO:0009746 ! response to hexose stimulus +is_a: GO:0034287 ! detection of monosaccharide stimulus + +[Term] +id: GO:0009733 +name: response to auxin stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009734 +name: auxin mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated in response to detection of auxin." [GOC:mah, GOC:sm] +synonym: "auxin mediated signalling" EXACT [] +is_a: GO:0009733 ! response to auxin stimulus +is_a: GO:0009755 ! hormone-mediated signaling + +[Term] +id: GO:0009735 +name: response to cytokinin stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009736 +name: cytokinin mediated signaling +namespace: biological_process +def: "A series of molecular signals induced by the detection of cytokinin." [GOC:sm] +synonym: "cytokinin mediated signalling" EXACT [] +is_a: GO:0009735 ! response to cytokinin stimulus +is_a: GO:0009755 ! hormone-mediated signaling + +[Term] +id: GO:0009737 +name: response to abscisic acid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009738 +name: abscisic acid mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of abscisic acid." [GOC:sm] +synonym: "abscisic acid mediated signalling" EXACT [] +is_a: GO:0009737 ! response to abscisic acid stimulus +is_a: GO:0009755 ! hormone-mediated signaling + +[Term] +id: GO:0009739 +name: response to gibberellin stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] +synonym: "response to gibberellic acid stimulus" NARROW [] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009740 +name: gibberellic acid mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm] +synonym: "GA-signaling" EXACT [] +synonym: "gibberellic acid mediated signalling" EXACT [] +synonym: "gibberellic acid signaling" EXACT [] +is_a: GO:0009739 ! response to gibberellin stimulus +is_a: GO:0010476 ! gibberellin-mediated signaling + +[Term] +id: GO:0009741 +name: response to brassinosteroid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009742 +name: brassinosteroid mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm] +synonym: "brassinosteroid mediated signalling" EXACT [] +is_a: GO:0009741 ! response to brassinosteroid stimulus +is_a: GO:0043401 ! steroid hormone mediated signaling + +[Term] +id: GO:0009743 +name: response to carbohydrate stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0009744 +name: response to sucrose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] +is_a: GO:0034285 ! response to disaccharide stimulus + +[Term] +id: GO:0009745 +name: sucrose mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm] +synonym: "sucrose mediated signalling" EXACT [] +is_a: GO:0009744 ! response to sucrose stimulus +is_a: GO:0010182 ! sugar mediated signaling + +[Term] +id: GO:0009746 +name: response to hexose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] +is_a: GO:0034284 ! response to monosaccharide stimulus + +[Term] +id: GO:0009747 +name: hexokinase-dependent signaling +namespace: biological_process +def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm] +synonym: "hexokinase-dependent signalling" EXACT [] +is_a: GO:0009757 ! hexose mediated signaling + +[Term] +id: GO:0009748 +name: hexokinase-independent signaling +namespace: biological_process +def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm] +synonym: "hexokinase-independent signalling" EXACT [] +is_a: GO:0009757 ! hexose mediated signaling + +[Term] +id: GO:0009749 +name: response to glucose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] +is_a: GO:0009746 ! response to hexose stimulus + +[Term] +id: GO:0009750 +name: response to fructose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] +is_a: GO:0009746 ! response to hexose stimulus + +[Term] +id: GO:0009751 +name: response to salicylic acid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0009752 +name: detection of salicylic acid stimulus +namespace: biological_process +def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of salicylic acid stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009751 ! response to salicylic acid stimulus + +[Term] +id: GO:0009753 +name: response to jasmonic acid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0009754 +name: detection of jasmonic acid stimulus +namespace: biological_process +def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm] +synonym: "perception of jasmonic acid stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009726 ! detection of endogenous stimulus +is_a: GO:0009753 ! response to jasmonic acid stimulus + +[Term] +id: GO:0009755 +name: hormone-mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] +synonym: "hormone mediated signalling" EXACT [] +xref: Reactome:163359 +xref: Reactome:212022 +xref: Reactome:221785 +xref: Reactome:230363 +xref: Reactome:238400 +xref: Reactome:244950 +xref: Reactome:249830 +xref: Reactome:252563 +xref: Reactome:255742 +xref: Reactome:259135 +xref: Reactome:262492 +xref: Reactome:268452 +xref: Reactome:286664 +xref: Reactome:288341 +is_a: GO:0007242 ! intracellular signaling cascade +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009756 +name: carbohydrate mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm] +synonym: "carbohydrate mediated signalling" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0009757 +name: hexose mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm] +synonym: "hexose mediated signalling" EXACT [] +is_a: GO:0009746 ! response to hexose stimulus +is_a: GO:0009756 ! carbohydrate mediated signaling + +[Term] +id: GO:0009758 +name: carbohydrate utilization +namespace: biological_process +def: "Series of processes that involve carbohydrate sensing, carbohydrate transportation and carbohydrate metabolism which lead to the utilization of carbohydrates." [GOC:sm] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0009759 +name: indole glucosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai] +subset: gosubset_prok +synonym: "indole glucosinolate anabolism" EXACT [] +synonym: "indole glucosinolate biosynthesis" EXACT [] +synonym: "indole glucosinolate formation" EXACT [] +synonym: "indole glucosinolate synthesis" EXACT [] +xref: MetaCyc:PWY-601 +is_a: GO:0019761 ! glucosinolate biosynthetic process +is_a: GO:0042343 ! indole glucosinolate metabolic process +is_a: GO:0042435 ! indole derivative biosynthetic process + +[Term] +id: GO:0009760 +name: C4 photosynthesis +namespace: biological_process +def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360] +is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide +is_a: GO:0019685 ! photosynthesis, dark reaction +is_a: GO:0044236 ! multicellular organismal metabolic process + +[Term] +id: GO:0009761 +name: CAM photosynthesis +namespace: biological_process +def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952] +is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide +is_a: GO:0019685 ! photosynthesis, dark reaction + +[Term] +id: GO:0009762 +name: NADP-malic enzyme C4 photosynthesis +namespace: biological_process +def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762] +xref: MetaCyc:PWY-241 +is_a: GO:0009760 ! C4 photosynthesis + +[Term] +id: GO:0009763 +name: NAD-malic enzyme C4 photosynthesis +namespace: biological_process +def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762] +is_a: GO:0009760 ! C4 photosynthesis + +[Term] +id: GO:0009764 +name: PEP carboxykinase C4 photosynthesis +namespace: biological_process +def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762] +is_a: GO:0009760 ! C4 photosynthesis + +[Term] +id: GO:0009765 +name: photosynthesis, light harvesting +namespace: biological_process +def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm] +synonym: "energy dissipation" RELATED [] +is_a: GO:0006091 ! generation of precursor metabolites and energy +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009766 +name: primary charge separation +namespace: biological_process +def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431] +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009767 +name: photosynthetic electron transport chain +namespace: biological_process +def: "A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684] +synonym: "electron carrier, chlorophyll electron transport system" EXACT [] +is_a: GO:0022900 ! electron transport chain +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009768 +name: photosynthesis, light harvesting in photosystem I +namespace: biological_process +def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jic, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009765 ! photosynthesis, light harvesting + +[Term] +id: GO:0009769 +name: photosynthesis, light harvesting in photosystem II +namespace: biological_process +def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jic, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009765 ! photosynthesis, light harvesting + +[Term] +id: GO:0009770 +name: primary charge separation in photosystem I +namespace: biological_process +def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jic, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009766 ! primary charge separation + +[Term] +id: GO:0009771 +name: primary charge separation in photosystem II +namespace: biological_process +def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jic, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009766 ! primary charge separation + +[Term] +id: GO:0009772 +name: photosynthetic electron transport in photosystem II +namespace: biological_process +def: "Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jic, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009773 +name: photosynthetic electron transport in photosystem I +namespace: biological_process +def: "Electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jic, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009774 +name: photosynthetic electron transport in plastoquinone +namespace: biological_process +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009775 +name: photosynthetic electron transport in cytochrome b6/f +namespace: biological_process +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009776 +name: photosynthetic electron transport in plastocyanin +namespace: biological_process +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009777 +name: photosynthetic phosphorylation +namespace: biological_process +def: "Any metabolic process by which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684] +synonym: "photosynthetic ATP synthesis" NARROW [] +is_a: GO:0016310 ! phosphorylation +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009778 +name: cyclic photosynthetic phosphorylation +namespace: biological_process +def: "ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684] +is_a: GO:0009777 ! photosynthetic phosphorylation + +[Term] +id: GO:0009779 +name: noncyclic photosynthetic phosphorylation +namespace: biological_process +def: "ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684] +is_a: GO:0009777 ! photosynthetic phosphorylation + +[Term] +id: GO:0009780 +name: photosynthetic NADP+ reduction +namespace: biological_process +def: "The process by which NADP+ is reduced to NADPH. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jic, ISBN:0716746840, ISBN:0816017360] +is_a: GO:0006740 ! NADPH regeneration +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009781 +name: photosynthetic water oxidation +namespace: biological_process +def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jic, ISBN:0716743663, ISBN:0816017360] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0010242 + +[Term] +id: GO:0009782 +name: photosystem I antenna complex +namespace: cellular_component +def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0009522 ! photosystem I + +[Term] +id: GO:0009783 +name: photosystem II antenna complex +namespace: cellular_component +def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0009523 ! photosystem II + +[Term] +id: GO:0009784 +name: transmembrane receptor histidine kinase activity +namespace: molecular_function +def: "A transmembrane receptor that perceives a stimulus and that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr] +subset: gosubset_prok +is_a: GO:0004673 ! protein histidine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + +[Term] +id: GO:0009785 +name: blue light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 440nm and 500nm." [GOC:lr, GOC:sm] +synonym: "blue light signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0009786 +name: regulation of asymmetric cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0009787 +name: regulation of abscisic acid mediated signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr] +synonym: "regulation of abscisic acid mediated signalling" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009738 ! abscisic acid mediated signaling + +[Term] +id: GO:0009788 +name: negative regulation of abscisic acid mediated signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr] +synonym: "down regulation of abscisic acid mediated signaling" EXACT [] +synonym: "down-regulation of abscisic acid mediated signaling" EXACT [] +synonym: "downregulation of abscisic acid mediated signaling" EXACT [] +synonym: "inhibition of abscisic acid mediated signaling" NARROW [] +synonym: "negative regulation of abscisic acid mediated signalling" EXACT [] +is_a: GO:0009787 ! regulation of abscisic acid mediated signaling +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009738 ! abscisic acid mediated signaling + +[Term] +id: GO:0009789 +name: positive regulation of abscisic acid mediated signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of abscisic acid mediated signal transduction." [GOC:lr] +synonym: "activation of abscisic acid mediated signaling" NARROW [] +synonym: "positive regulation of abscisic acid mediated signalling" EXACT [] +synonym: "stimulation of abscisic acid mediated signaling" NARROW [] +synonym: "up regulation of abscisic acid mediated signaling" EXACT [] +synonym: "up-regulation of abscisic acid mediated signaling" EXACT [] +synonym: "upregulation of abscisic acid mediated signaling" EXACT [] +is_a: GO:0009787 ! regulation of abscisic acid mediated signaling +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009738 ! abscisic acid mediated signaling + +[Term] +id: GO:0009790 +name: embryonic development +namespace: biological_process +alt_id: GO:0009795 +def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] +subset: goslim_generic +subset: goslim_plant +synonym: "embryogenesis" EXACT [] +synonym: "embryogenesis and morphogenesis" BROAD [] +synonym: "embryonal development" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0009791 +name: post-embryonic development +namespace: biological_process +def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] +subset: goslim_plant +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0009792 +name: embryonic development ending in birth or egg hatching +namespace: biological_process +def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] +synonym: "embryogenesis (sensu Metazoa)" EXACT [] +synonym: "embryonic development (sensu Metazoa)" RELATED [] +is_a: GO:0009790 ! embryonic development + +[Term] +id: GO:0009793 +name: embryonic development ending in seed dormancy +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy." [GOC:go_curators, GOC:mtg_sensu] +synonym: "embryogenesis (sensu Magnoliophyta)" EXACT [] +synonym: "embryonic development (sensu Magnoliophyta)" EXACT [] +is_a: GO:0009790 ! embryonic development +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0009794 +name: regulation of mitotic cell cycle, embryonic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "control of embryonic mitotic cell cycle progression" EXACT [] +synonym: "embryonic mitotic cell cycle control" EXACT [] +synonym: "embryonic mitotic cell cycle modulation" EXACT [] +synonym: "embryonic mitotic cell cycle regulation" EXACT [] +synonym: "embryonic mitotic cell cycle regulator" RELATED [] +synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0045995 ! regulation of embryonic development +relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0009798 +name: axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of a pattern along a line or a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] +synonym: "axis determination" EXACT [] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0009799 +name: determination of symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0009800 +name: cinnamic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] +subset: gosubset_prok +synonym: "cinnamic acid anabolism" EXACT [] +synonym: "cinnamic acid biosynthesis" EXACT [] +synonym: "cinnamic acid formation" EXACT [] +synonym: "cinnamic acid synthesis" EXACT [] +synonym: "cinnamylic acid biosynthesis" EXACT [] +synonym: "cinnamylic acid biosynthetic process" EXACT [] +synonym: "phenylacrylic acid biosynthesis" EXACT [] +synonym: "phenylacrylic acid biosynthetic process" EXACT [] +synonym: "phenylpropenoic acid biosynthesis" EXACT [] +synonym: "phenylpropenoic acid biosynthetic process" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009803 ! cinnamic acid metabolic process + +[Term] +id: GO:0009801 +name: cinnamic acid ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl] +subset: gosubset_prok +synonym: "cinnamic acid ester metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0009802 +name: cinnamic acid ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl] +subset: gosubset_prok +synonym: "cinnamic acid ester anabolism" EXACT [] +synonym: "cinnamic acid ester biosynthesis" EXACT [] +synonym: "cinnamic acid ester formation" EXACT [] +synonym: "cinnamic acid ester synthesis" EXACT [] +synonym: "cinnamylic acid ester biosynthesis" EXACT [] +synonym: "cinnamylic acid ester biosynthetic process" EXACT [] +synonym: "phenylacrylic acid ester biosynthesis" EXACT [] +synonym: "phenylacrylic acid ester biosynthetic process" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009801 ! cinnamic acid ester metabolic process +relationship: part_of GO:0009803 ! cinnamic acid metabolic process + +[Term] +id: GO:0009803 +name: cinnamic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] +subset: gosubset_prok +synonym: "cinnamic acid metabolism" EXACT [] +synonym: "cinnamylic acid metabolic process" EXACT [] +synonym: "cinnamylic acid metabolism" EXACT [] +synonym: "phenylacrylic acid metabolic process" EXACT [] +synonym: "phenylacrylic acid metabolism" EXACT [] +synonym: "phenylpropenoic acid metabolic process" EXACT [] +synonym: "phenylpropenoic acid metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009804 +name: coumarin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] +subset: gosubset_prok +synonym: "coumarin metabolism" EXACT [] +xref: Reactome:206872 +xref: Reactome:216411 +xref: Reactome:225273 +xref: Reactome:233957 +xref: Reactome:76453 +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0009805 +name: coumarin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] +subset: gosubset_prok +synonym: "coumarin anabolism" EXACT [] +synonym: "coumarin biosynthesis" EXACT [] +synonym: "coumarin formation" EXACT [] +synonym: "coumarin synthesis" EXACT [] +xref: MetaCyc:PWY-5176 +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process + +[Term] +id: GO:0009806 +name: lignan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] +subset: gosubset_prok +synonym: "lignan metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0009807 +name: lignan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] +subset: gosubset_prok +synonym: "lignan anabolism" EXACT [] +synonym: "lignan biosynthesis" EXACT [] +synonym: "lignan formation" EXACT [] +synonym: "lignan synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009806 ! lignan metabolic process + +[Term] +id: GO:0009808 +name: lignin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl] +subset: gosubset_prok +synonym: "lignin metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0009809 +name: lignin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684] +subset: gosubset_prok +synonym: "lignin anabolism" EXACT [] +synonym: "lignin biosynthesis" EXACT [] +synonym: "lignin formation" EXACT [] +synonym: "lignin synthesis" EXACT [] +xref: MetaCyc:PWY-361 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009808 ! lignin metabolic process + +[Term] +id: GO:0009810 +name: stilbene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:311011625] +subset: gosubset_prok +synonym: "stilbene metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0009811 +name: stilbene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251] +subset: gosubset_prok +synonym: "stilbene anabolism" EXACT [] +synonym: "stilbene biosynthesis" EXACT [] +synonym: "stilbene formation" EXACT [] +synonym: "stilbene synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009810 ! stilbene metabolic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0043450 ! alkene biosynthetic process + +[Term] +id: GO:0009812 +name: flavonoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684] +subset: gosubset_prok +synonym: "flavonoid metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0009813 +name: flavonoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684] +subset: gosubset_prok +synonym: "flavonoid anabolism" EXACT [] +synonym: "flavonoid biosynthesis" EXACT [] +synonym: "flavonoid formation" EXACT [] +synonym: "flavonoid synthesis" EXACT [] +xref: MetaCyc:PWY1F-402 +xref: MetaCyc:PWY1F-FLAVSYN +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009812 ! flavonoid metabolic process + +[Term] +id: GO:0009814 +name: defense response, incompatible interaction +namespace: biological_process +def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr] +synonym: "defence response incompatible interaction" EXACT [] +synonym: "defence response to pathogen, incompatible interaction" EXACT [] +synonym: "resistance response to pathogen" EXACT [] +synonym: "response to pathogen (incompatible interaction)" EXACT [] +is_a: GO:0045087 ! innate immune response +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009815 +name: 1-aminocyclopropane-1-carboxylate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ascorbate + 1-aminocyclopropane-1-carboxylate + O2 = 2 H2O + ethene (ethylene) + L-dehydro-ascorbate + hydrocyanic acid + CO2." [EC:1.14.17.4, MetaCyc:ETHYL-RXN] +synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4] +synonym: "ACC oxidase activity" EXACT [] +synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4] +synonym: "ethene-forming enzyme" BROAD [] +synonym: "ethylene-forming enzyme" BROAD [] +xref: EC:1.14.17.4 +xref: MetaCyc:ETHYL-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0009816 +name: defense response to bacterium, incompatible interaction +namespace: biological_process +def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr] +synonym: "defence response to bacterium, incompatible interaction" EXACT [] +synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT [] +synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT [] +synonym: "resistance response to pathogenic bacteria" EXACT [] +synonym: "resistance response to pathogenic bacterium" EXACT [] +synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT [] +synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT [] +is_a: GO:0009814 ! defense response, incompatible interaction +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0009817 +name: defense response to fungus, incompatible interaction +namespace: biological_process +def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr] +synonym: "defence response to fungus, incompatible interaction" EXACT [] +synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT [] +synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT [] +synonym: "defense response to fungi, incompatible interaction" EXACT [] +synonym: "resistance response to pathogenic fungi" EXACT [] +synonym: "resistance response to pathogenic fungus" EXACT [] +synonym: "response to pathogenic fungi (incompatible interaction)" EXACT [] +synonym: "response to pathogenic fungus (incompatible interaction)" EXACT [] +is_a: GO:0009814 ! defense response, incompatible interaction +is_a: GO:0050832 ! defense response to fungus + +[Term] +id: GO:0009818 +name: defense response to protozoan, incompatible interaction +namespace: biological_process +def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr] +synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT [] +synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT [] +synonym: "defence response to protozoan, incompatible interaction" EXACT [] +synonym: "resistance response to pathogenic protozoa" EXACT [] +synonym: "resistance response to pathogenic protozoan" EXACT [] +synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT [] +synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT [] +is_a: GO:0009814 ! defense response, incompatible interaction +is_a: GO:0042832 ! defense response to protozoan + +[Term] +id: GO:0009819 +name: drought recovery +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr] +synonym: "drought tolerance" RELATED [] +is_a: GO:0009414 ! response to water deprivation + +[Term] +id: GO:0009820 +name: alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] +subset: gosubset_prok +synonym: "alkaloid metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0009821 +name: alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] +subset: gosubset_prok +synonym: "alkaloid anabolism" EXACT [] +synonym: "alkaloid biosynthesis" EXACT [] +synonym: "alkaloid formation" EXACT [] +synonym: "alkaloid synthesis" EXACT [] +xref: UM-BBD_enzymeID:e0711 +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0044271 ! nitrogen compound biosynthetic process + +[Term] +id: GO:0009822 +name: alkaloid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:01221146743] +subset: gosubset_prok +synonym: "alkaloid breakdown" EXACT [] +synonym: "alkaloid catabolism" EXACT [] +synonym: "alkaloid degradation" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0009823 +name: cytokinin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr] +subset: gosubset_prok +synonym: "cytokinin breakdown" EXACT [] +synonym: "cytokinin catabolism" EXACT [] +synonym: "cytokinin degradation" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0009824 +name: adenylate dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + AMP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-monophosphate." [EC:2.5.1.27] +synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] +synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.27] +synonym: "adenylate isopentenyltransferase activity" EXACT [] +synonym: "cytokinin synthase activity" EXACT [] +synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] +synonym: "isopentenyltransferase activity" EXACT [] +xref: EC:2.5.1.27 +xref: MetaCyc:ADENYLATE-ISOPENTENYLTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0009825 +name: multidimensional cell growth +namespace: biological_process +def: "The process by which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399] +subset: gosubset_prok +synonym: "cell growth in three dimensions" EXACT [] +synonym: "cell growth in two dimensions" NARROW [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0009826 +name: unidimensional cell growth +namespace: biological_process +def: "The process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [ISBN:0943088399] +subset: gosubset_prok +synonym: "cell elongation" NARROW [] +synonym: "cell growth along one axis" EXACT [] +synonym: "cell growth in one dimension" EXACT [] +synonym: "polar cell growth" EXACT [] +synonym: "polarized cell growth" EXACT [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0009827 +name: plant-type cell wall modification +namespace: biological_process +def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr, GOC:mtg_sensu] +synonym: "cell wall modification (sensu Magnoliophyta) " EXACT [] +synonym: "cellulose and pectin-containing cell wall modification" EXACT [] +is_a: GO:0009664 ! plant-type cell wall organization +is_a: GO:0042545 ! cell wall modification + +[Term] +id: GO:0009828 +name: plant-type cell wall loosening +namespace: biological_process +def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. As in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr, GOC:mtg_sensu] +synonym: "cell wall loosening (sensu Magnoliophyta)" EXACT [] +synonym: "cellulose and pectin-containing cell wall loosening" EXACT [] +is_a: GO:0009827 ! plant-type cell wall modification + +[Term] +id: GO:0009829 +name: cell wall modification during ripening +namespace: biological_process +def: "The series of events that occur during ripening that result in chemical or structural alterations of existing cell walls." [GOC:lr] +is_a: GO:0009827 ! plant-type cell wall modification +relationship: part_of GO:0009835 ! ripening + +[Term] +id: GO:0009830 +name: cell wall modification during abscission +namespace: biological_process +def: "The series of events that occur during abscission that result in chemical and structural alterations of existing cell walls." [GOC:lr] +is_a: GO:0009827 ! plant-type cell wall modification +relationship: part_of GO:0009838 ! abscission + +[Term] +id: GO:0009831 +name: plant-type cell wall modification during multidimensional cell growth +namespace: biological_process +def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin." [GOC:lr, GOC:mtg_sensu] +synonym: "cell wall modification during cell expansion (sensu Magnoliophyta)" EXACT [] +synonym: "cell wall modification during multidimensional cell growth (sensu Magnoliophyta)" EXACT [] +synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" EXACT [] +is_a: GO:0009827 ! plant-type cell wall modification +is_a: GO:0042547 ! cell wall modification during multidimensional cell growth + +[Term] +id: GO:0009832 +name: plant-type cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cellulose and pectin-containing cell wall." [GOC:go_curators, GOC:lr, GOC:mtg_sensu] +synonym: "cell wall anabolism (sensu Magnoliophyta)" EXACT [] +synonym: "cell wall assembly (sensu Magnoliophyta)" EXACT [] +synonym: "cell wall biosynthetic process (sensu Magnoliophyta)" EXACT [] +synonym: "cell wall formation (sensu Magnoliophyta)" EXACT [] +synonym: "cell wall synthesis (sensu Magnoliophyta)" EXACT [] +synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT [] +is_a: GO:0009664 ! plant-type cell wall organization +is_a: GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0009833 +name: primary cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion." [GOC:lr, GOC:mtg_sensu] +synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT [] +synonym: "plant-type primary cell wall biogenesis" EXACT [] +synonym: "primary cell wall anabolism (sensu Magnoliophyta)" EXACT [] +synonym: "primary cell wall biosynthetic process (sensu Magnoliophyta)" EXACT [] +synonym: "primary cell wall formation (sensu Magnoliophyta)" EXACT [] +synonym: "primary cell wall synthesis (sensu Magnoliophyta)" EXACT [] +is_a: GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0009834 +name: secondary cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inextensible cellulose and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete." [GOC:lr, GOC:mtg_sensu] +synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT [] +synonym: "plant-type secondary cell wall biogenesis" EXACT [] +synonym: "secondary cell wall anabolism (sensu Magnoliophyta)" EXACT [] +synonym: "secondary cell wall biosynthetic process (sensu Magnoliophyta)" EXACT [] +synonym: "secondary cell wall formation (sensu Magnoliophyta)" EXACT [] +synonym: "secondary cell wall synthesis (sensu Magnoliophyta)" EXACT [] +is_a: GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0009835 +name: ripening +namespace: biological_process +def: "The series of events causing changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) to make it more attractive to animals and/or aid in seed dispersal." [GOC:lr] +subset: goslim_plant +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0009836 +name: ripening, climacteric +namespace: biological_process +def: "A ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840] +is_a: GO:0009835 ! ripening + +[Term] +id: GO:0009837 +name: ripening, non-climacteric +namespace: biological_process +def: "A ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840] +is_a: GO:0009835 ! ripening + +[Term] +id: GO:0009838 +name: abscission +namespace: biological_process +def: "The controlled shedding of a body part." [ISBN:0140514031] +subset: goslim_plant +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0009839 +name: SCF complex substrate recognition subunit +namespace: cellular_component +def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +replaced_by: GO:0019005 + +[Term] +id: GO:0009840 +name: chloroplastic endopeptidase Clp complex +namespace: cellular_component +def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] +is_a: GO:0009368 ! endopeptidase Clp complex +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0009841 +name: mitochondrial endopeptidase Clp complex +namespace: cellular_component +def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] +is_a: GO:0009368 ! endopeptidase Clp complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0009842 +name: cyanelle +namespace: cellular_component +def: "Plastid type found in Glaucophyta having unstacked thylakoid membranes bearing phycobilisomes; cyanelles are bound by a double membrane and a peptidoglycan layer." [ISBN:052131687] +subset: gosubset_prok +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009843 +name: cyanelle thylakoid +namespace: cellular_component +def: "A thylakoid found in a cyanelle, a type of plastid found in certain algae; contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "thylakoid (sensu Glaucocystophyceae)" EXACT [] +is_a: GO:0031976 ! plastid thylakoid +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0009844 +name: germination +namespace: biological_process +alt_id: GO:0009565 +def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr] +comment: This term was made obsolete because it is a grouping term without biological significance. +is_obsolete: true + +[Term] +id: GO:0009845 +name: seed germination +namespace: biological_process +def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0009846 +name: pollen germination +namespace: biological_process +def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0009847 +name: spore germination +namespace: biological_process +def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] +subset: gosubset_prok +synonym: "spore germination (sensu Fungi)" NARROW [] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0009848 +name: indoleacetic acid biosynthetic process via tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566] +subset: gosubset_prok +synonym: "IAA biosynthetic process via tryptophan" EXACT [] +synonym: "indoleacetic acid anabolism via tryptophan" EXACT [] +synonym: "indoleacetic acid formation via tryptophan" EXACT [] +synonym: "indoleacetic acid synthesis via tryptophan" EXACT [] +xref: MetaCyc:PWY-581 +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0009684 ! indoleacetic acid biosynthetic process + +[Term] +id: GO:0009849 +name: tryptophan-independent indoleacetic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566] +subset: gosubset_prok +synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT [] +synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT [] +synonym: "tryptophan-independent IAA biosynthetic process" EXACT [] +synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT [] +synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT [] +synonym: "tryptophan-independent indoleacetic acid formation" EXACT [] +synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT [] +xref: MetaCyc:PWY-581 +is_a: GO:0009684 ! indoleacetic acid biosynthetic process + +[Term] +id: GO:0009850 +name: auxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr] +subset: gosubset_prok +synonym: "auxin metabolism" EXACT [] +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0009851 +name: auxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743] +subset: gosubset_prok +synonym: "auxin anabolism" EXACT [] +synonym: "auxin biosynthesis" EXACT [] +synonym: "auxin formation" EXACT [] +synonym: "auxin synthesis" EXACT [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0009852 +name: auxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684] +subset: gosubset_prok +synonym: "auxin breakdown" EXACT [] +synonym: "auxin catabolism" EXACT [] +synonym: "auxin degradation" EXACT [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0009853 +name: photorespiration +namespace: biological_process +def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: MetaCyc:PWY-181 +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0009854 +name: oxidative photosynthetic carbon pathway +namespace: biological_process +def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:00943088399] +subset: gosubset_prok +is_a: GO:0043094 ! cellular metabolic compound salvage +relationship: part_of GO:0009853 ! photorespiration + +[Term] +id: GO:0009855 +name: determination of bilateral symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] +is_a: GO:0009799 ! determination of symmetry + +[Term] +id: GO:0009856 +name: pollination +namespace: biological_process +def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the stigma and continuing up to, but not including, fertilization, as defined by sperm-central cell fusion." [GOC:tb, PMID:10973091] +subset: goslim_plant +is_a: GO:0022414 ! reproductive process +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0009858 +name: compatible pollen-pistil interaction +namespace: biological_process +def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819] +comment: This term was made obsolete because it represents a phenotype. +is_obsolete: true + +[Term] +id: GO:0009859 +name: pollen hydration +namespace: biological_process +def: "The process by which water is taken up by pollen." [GOC:lr] +is_a: GO:0006833 ! water transport +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0009860 +name: pollen tube growth +namespace: biological_process +def: "Growth of pollen via tip extension of the intine wall." [ISBN:00943088399] +is_a: GO:0009932 ! cell tip growth +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0048868 ! pollen tube development + +[Term] +id: GO:0009861 +name: jasmonic acid and ethylene-dependent systemic resistance +namespace: biological_process +def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273] +synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT [] +is_a: GO:0009611 ! response to wounding +is_a: GO:0009814 ! defense response, incompatible interaction + +[Term] +id: GO:0009862 +name: systemic acquired resistance, salicylic acid mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy] +synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT [] +synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT [] +is_a: GO:0009863 ! salicylic acid mediated signaling pathway +relationship: part_of GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:0009863 +name: salicylic acid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by salicylic acid." [GOC:jy] +synonym: "salicylic acid mediated signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade +is_a: GO:0009751 ! response to salicylic acid stimulus + +[Term] +id: GO:0009864 +name: induced systemic resistance, jasmonic acid mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy] +synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] +synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0009867 ! jasmonic acid mediated signaling pathway +relationship: part_of GO:0009682 ! induced systemic resistance + +[Term] +id: GO:0009865 +name: pollen tube adhesion +namespace: biological_process +def: "The process by which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0009875 ! pollen-pistil interaction +relationship: part_of GO:0048868 ! pollen tube development + +[Term] +id: GO:0009866 +name: induced systemic resistance, ethylene mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy] +synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT [] +synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT [] +synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT [] +synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT [] +synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0009873 ! ethylene mediated signaling pathway +relationship: part_of GO:0009682 ! induced systemic resistance + +[Term] +id: GO:0009867 +name: jasmonic acid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy] +synonym: "jasmonic acid mediated signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade +is_a: GO:0009753 ! response to jasmonic acid stimulus + +[Term] +id: GO:0009868 +name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy] +synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] +synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] +synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] +is_a: GO:0009867 ! jasmonic acid mediated signaling pathway +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0009869 +name: incompatible pollen-pistil interaction +namespace: biological_process +def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566] +comment: This term was made obsolete because it represents a phenotype. +is_obsolete: true + +[Term] +id: GO:0009870 +name: defense response signaling pathway, resistance gene-dependent +namespace: biological_process +def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339] +synonym: "defence response signaling pathway, resistance gene-dependent" EXACT [] +synonym: "defence response signalling pathway, resistance gene-dependent" EXACT [] +synonym: "defense response signalling pathway, resistance gene-dependent" EXACT [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0009871 +name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy] +synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] +synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] +synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT [] +is_a: GO:0009873 ! ethylene mediated signaling pathway +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0009872 +name: gametophytic self-incompatibility +namespace: biological_process +def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] +comment: This term was made obsolete because it represents a phenotype. +is_obsolete: true + +[Term] +id: GO:0009873 +name: ethylene mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by ethylene (ethene)." [GOC:jy] +synonym: "ethene mediated signaling pathway" EXACT [] +synonym: "ethene mediated signalling pathway" EXACT [] +synonym: "ethylene mediated signalling pathway" EXACT [] +is_a: GO:0000160 ! two-component signal transduction system (phosphorelay) +is_a: GO:0009723 ! response to ethylene stimulus +is_a: GO:0009755 ! hormone-mediated signaling + +[Term] +id: GO:0009874 +name: sporophytic self-incompatibility +namespace: biological_process +def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] +comment: This term was made obsolete because it represents a phenotype. +is_obsolete: true + +[Term] +id: GO:0009875 +name: pollen-pistil interaction +namespace: biological_process +def: "The interaction between a pollen grain and pistil." [GOC:go_curators] +subset: goslim_plant +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0009876 +name: pollen adhesion +namespace: biological_process +def: "The process by which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0009877 +name: nodulation +namespace: biological_process +def: "The formation of nitrogen-fixing root nodules on plant roots." [SP_KW:KW-0536] +is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0009878 +name: nodule morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the nodule are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0009877 ! nodulation + +[Term] +id: GO:0009879 +name: determination of radial symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators] +is_a: GO:0009799 ! determination of symmetry +relationship: part_of GO:0009956 ! radial pattern formation + +[Term] +id: GO:0009880 +name: embryonic pattern specification +namespace: biological_process +def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] +synonym: "embryonic pattern biosynthesis" BROAD [] +synonym: "embryonic pattern formation" BROAD [] +synonym: "ventral/lateral system" RELATED [] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0009881 +name: photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] +subset: gosubset_prok +synonym: "blue-sensitive opsin" NARROW [] +synonym: "green-sensitive opsin" NARROW [] +synonym: "long-wave-sensitive opsin" NARROW [] +synonym: "opsin" NARROW [] +synonym: "red-sensitive opsin" NARROW [] +synonym: "short-wave-sensitive opsin" NARROW [] +synonym: "UV-sensitive opsin" NARROW [] +synonym: "violet-sensitive opsin" NARROW [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0009882 +name: blue light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] +subset: gosubset_prok +is_a: GO:0009881 ! photoreceptor activity + +[Term] +id: GO:0009883 +name: red or far-red light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] +synonym: "red/far-red light photoreceptor activity" EXACT [] +is_a: GO:0009881 ! photoreceptor activity + +[Term] +id: GO:0009884 +name: cytokinin receptor activity +namespace: molecular_function +def: "Combining with a cytokinin to initiate a change in cell activity." [GOC:lr] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0009885 +name: transmembrane histidine kinase cytokinin receptor activity +namespace: molecular_function +def: "A transmembrane receptor of cytokinins that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr] +is_a: GO:0009784 ! transmembrane receptor histidine kinase activity +is_a: GO:0009884 ! cytokinin receptor activity + +[Term] +id: GO:0009886 +name: post-embryonic morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009791 ! post-embryonic development + +[Term] +id: GO:0009887 +name: organ morphogenesis +namespace: biological_process +def: "Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "histogenesis and organogenesis" BROAD [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048513 ! organ development + +[Term] +id: GO:0009888 +name: tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] +synonym: "histogenesis" EXACT [] +synonym: "histogenesis and organogenesis" BROAD [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048513 ! organ development + +[Term] +id: GO:0009889 +name: regulation of biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of anabolism" EXACT [] +synonym: "regulation of biosynthesis" EXACT [] +synonym: "regulation of formation" EXACT [] +synonym: "regulation of synthesis" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0009058 ! biosynthetic process + +[Term] +id: GO:0009890 +name: negative regulation of biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of biosynthetic process" EXACT [] +synonym: "down-regulation of biosynthetic process" EXACT [] +synonym: "downregulation of biosynthetic process" EXACT [] +synonym: "inhibition of biosynthetic process" NARROW [] +synonym: "negative regulation of anabolism" EXACT [] +synonym: "negative regulation of biosynthesis" EXACT [] +synonym: "negative regulation of formation" EXACT [] +synonym: "negative regulation of synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0009892 ! negative regulation of metabolic process +relationship: negatively_regulates GO:0009058 ! biosynthetic process + +[Term] +id: GO:0009891 +name: positive regulation of biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of biosynthetic process" NARROW [] +synonym: "positive regulation of anabolism" EXACT [] +synonym: "positive regulation of biosynthesis" EXACT [] +synonym: "positive regulation of formation" EXACT [] +synonym: "positive regulation of synthesis" EXACT [] +synonym: "stimulation of biosynthetic process" NARROW [] +synonym: "up regulation of biosynthetic process" EXACT [] +synonym: "up-regulation of biosynthetic process" EXACT [] +synonym: "upregulation of biosynthetic process" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0009893 ! positive regulation of metabolic process +relationship: positively_regulates GO:0009058 ! biosynthetic process + +[Term] +id: GO:0009892 +name: negative regulation of metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of metabolic process" EXACT [] +synonym: "down-regulation of metabolic process" EXACT [] +synonym: "downregulation of metabolic process" EXACT [] +synonym: "inhibition of metabolic process" NARROW [] +synonym: "negative regulation of metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0009893 +name: positive regulation of metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of metabolic process" NARROW [] +synonym: "positive regulation of metabolism" EXACT [] +synonym: "stimulation of metabolic process" NARROW [] +synonym: "up regulation of metabolic process" EXACT [] +synonym: "up-regulation of metabolic process" EXACT [] +synonym: "upregulation of metabolic process" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0009894 +name: regulation of catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of breakdown" EXACT [] +synonym: "regulation of catabolism" EXACT [] +synonym: "regulation of degradation" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0009056 ! catabolic process + +[Term] +id: GO:0009895 +name: negative regulation of catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of catabolic process" EXACT [] +synonym: "down-regulation of catabolic process" EXACT [] +synonym: "downregulation of catabolic process" EXACT [] +synonym: "inhibition of catabolic process" NARROW [] +synonym: "negative regulation of breakdown" EXACT [] +synonym: "negative regulation of catabolism" EXACT [] +synonym: "negative regulation of degradation" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0009894 ! regulation of catabolic process +relationship: negatively_regulates GO:0009056 ! catabolic process + +[Term] +id: GO:0009896 +name: positive regulation of catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of catabolic process" NARROW [] +synonym: "positive regulation of breakdown" EXACT [] +synonym: "positive regulation of catabolism" EXACT [] +synonym: "positive regulation of degradation" EXACT [] +synonym: "stimulation of catabolic process" NARROW [] +synonym: "up regulation of catabolic process" EXACT [] +synonym: "up-regulation of catabolic process" EXACT [] +synonym: "upregulation of catabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0009894 ! regulation of catabolic process +relationship: positively_regulates GO:0009056 ! catabolic process + +[Term] +id: GO:0009897 +name: external side of plasma membrane +namespace: cellular_component +def: "The side of the plasma membrane that is opposite to the side that faces the cytoplasm." [GOC:tb] +subset: gosubset_prok +synonym: "juxtamembrane" BROAD [] +synonym: "outer surface of cytoplasmic membrane" EXACT [] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0009898 +name: internal side of plasma membrane +namespace: cellular_component +def: "The side of the plasma membrane that faces the cytoplasm." [GOC:tb] +subset: gosubset_prok +synonym: "juxtamembrane" BROAD [] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0009899 +name: ent-kaurene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaurene + diphosphate." [EC:4.2.3.19, ISBN:0943088399] +synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19] +synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19] +synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] +synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] +xref: EC:4.2.3.19 +xref: MetaCyc:4.2.3.19-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0009900 +name: dehiscence +namespace: biological_process +def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322] +is_a: GO:0048609 ! reproductive process in a multicellular organism + +[Term] +id: GO:0009901 +name: anther dehiscence +namespace: biological_process +def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb] +is_a: GO:0009900 ! dehiscence +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0009902 +name: chloroplast relocation +namespace: biological_process +def: "The process by which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] +is_a: GO:0009658 ! chloroplast organization +is_a: GO:0051667 ! establishment of plastid localization + +[Term] +id: GO:0009903 +name: chloroplast avoidance movement +namespace: biological_process +def: "The relocation process by which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863] +synonym: "high-fluence-rate response" RELATED [] +is_a: GO:0009902 ! chloroplast relocation + +[Term] +id: GO:0009904 +name: chloroplast accumulation movement +namespace: biological_process +def: "The relocation process by which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863] +synonym: "low-fluence-rate response" RELATED [] +is_a: GO:0009902 ! chloroplast relocation + +[Term] +id: GO:0009905 +name: ent-copalyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, ISBN:0943088399] +synonym: "diterpene cyclase activity" BROAD [] +synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13] +synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] +synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] +xref: EC:5.5.1.13 +xref: MetaCyc:5.5.1.13-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0009906 +name: response to photoperiod, blue light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red] +is_a: GO:0009637 ! response to blue light +is_a: GO:0009648 ! photoperiodism + +[Term] +id: GO:0009907 +name: response to photoperiod, red light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red] +is_a: GO:0009648 ! photoperiodism +is_a: GO:0010114 ! response to red light + +[Term] +id: GO:0009908 +name: flower development +namespace: biological_process +alt_id: GO:0048409 +def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322] +subset: goslim_plant +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0009909 +name: regulation of flower development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0009908 ! flower development + +[Term] +id: GO:0009910 +name: negative regulation of flower development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of flower development." [GOC:go_curators] +synonym: "down regulation of flower development" EXACT [] +synonym: "down-regulation of flower development" EXACT [] +synonym: "downregulation of flower development" EXACT [] +synonym: "inhibition of flower development" NARROW [] +is_a: GO:0009909 ! regulation of flower development +is_a: GO:0048581 ! negative regulation of post-embryonic development +relationship: negatively_regulates GO:0009908 ! flower development + +[Term] +id: GO:0009911 +name: positive regulation of flower development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators] +synonym: "activation of flower development" NARROW [] +synonym: "stimulation of flower development" NARROW [] +synonym: "up regulation of flower development" EXACT [] +synonym: "up-regulation of flower development" EXACT [] +synonym: "upregulation of flower development" EXACT [] +is_a: GO:0009909 ! regulation of flower development +is_a: GO:0048582 ! positive regulation of post-embryonic development +relationship: positively_regulates GO:0009908 ! flower development + +[Term] +id: GO:0009912 +name: auditory receptor cell fate commitment +namespace: biological_process +def: "The process by which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr] +synonym: "auditory hair cell fate commitment" EXACT [] +is_a: GO:0060120 ! inner ear receptor cell fate commitment +relationship: part_of GO:0042491 ! auditory receptor cell differentiation + +[Term] +id: GO:0009913 +name: epidermal cell differentiation +namespace: biological_process +alt_id: GO:0043355 +def: "The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:go_curators, GOC:mtg_sensu] +synonym: "epidermal cell differentiation (sensu Insecta)" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048730 ! epidermis morphogenesis + +[Term] +id: GO:0009914 +name: hormone transport +namespace: biological_process +def: "The directed movement of hormones into, out of, within or between cells." [GOC:tb] +subset: goslim_pir +is_a: GO:0006810 ! transport +is_a: GO:0010817 ! regulation of hormone levels + +[Term] +id: GO:0009915 +name: phloem loading +namespace: biological_process +def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0009916 +name: alternative oxidase activity +namespace: molecular_function +def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0009917 +name: sterol 5-alpha reductase activity +namespace: molecular_function +def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0009918 +name: sterol delta7 reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] +synonym: "sterol delta-7 reductase activity" EXACT [] +xref: MetaCyc:RXN-707 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0009919 +name: cytokinesis (sensu Viridiplantae) +namespace: biological_process +def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb] +comment: This term was made obsolete because its meaning was changed significantly. +is_obsolete: true +consider: GO:0000911 + +[Term] +id: GO:0009920 +name: cell plate formation involved in plant-type cell wall biogenesis +namespace: biological_process +def: "The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] +synonym: "cell plate formation (sensu Magnoliophyta)" RELATED [] +synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] +is_a: GO:0000919 ! cell plate formation +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007067 ! mitosis +relationship: part_of GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0009921 +name: auxin efflux carrier complex +namespace: cellular_component +def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0009922 +name: fatty acid elongase activity +namespace: molecular_function +def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] +is_a: GO:0004312 ! fatty-acid synthase activity + +[Term] +id: GO:0009923 +name: fatty acid elongase complex +namespace: cellular_component +def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] +is_a: GO:0031373 ! cytosolic fatty acid synthase complex + +[Term] +id: GO:0009924 +name: octadecanal decarbonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] +synonym: "aldehyde decarbonylase activity" EXACT [] +synonym: "decarbonylase activity" EXACT [EC:4.1.99.5] +synonym: "octadecanal alkane-lyase activity" EXACT [] +xref: EC:4.1.99.5 +xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0009925 +name: basal plasma membrane +namespace: cellular_component +def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0016323 ! basolateral plasma membrane +relationship: part_of GO:0045178 ! basal part of cell + +[Term] +id: GO:0009926 +name: auxin polar transport +namespace: biological_process +def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm] +is_a: GO:0009914 ! hormone transport + +[Term] +id: GO:0009927 +name: histidine phosphotransfer kinase activity +namespace: molecular_function +def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] +subset: gosubset_prok +is_a: GO:0004871 ! signal transducer activity +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0009930 +name: longitudinal side of cell surface +namespace: cellular_component +def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] +synonym: "longitudinal side of cell surface (sensu Magnoliophyta)" RELATED [] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0009931 +name: calcium-dependent protein serine/threonine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium ions." [GOC:mah] +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0009932 +name: cell tip growth +namespace: biological_process +def: "Growth that occurs specifically at the tip of a cell." [GOC:jic] +is_a: GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0009933 +name: meristem structural organization +namespace: biological_process +def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684] +synonym: "meristem organisation" EXACT [] +synonym: "meristem organization" BROAD [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048507 ! meristem development + +[Term] +id: GO:0009934 +name: regulation of meristem organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jic] +synonym: "regulation of meristem organisation" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0048509 ! regulation of meristem development +relationship: regulates GO:0009933 ! meristem structural organization + +[Term] +id: GO:0009935 +name: nutrient import +namespace: biological_process +def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm] +comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. +subset: gosubset_prok +synonym: "nutrient uptake" EXACT [] +is_obsolete: true +consider: GO:0006810 + +[Term] +id: GO:0009936 +name: expansin +namespace: molecular_function +def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0009505 +replaced_by: GO:0016049 + +[Term] +id: GO:0009937 +name: regulation of gibberellic acid mediated signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators] +synonym: "regulation of gibberellic acid mediated signalling" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009740 ! gibberellic acid mediated signaling + +[Term] +id: GO:0009938 +name: negative regulation of gibberellic acid mediated signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] +synonym: "down regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "down-regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "downregulation of gibberellic acid mediated signaling" EXACT [] +synonym: "inhibition of gibberellic acid mediated signaling" NARROW [] +synonym: "negative regulation of gibberellic acid mediated signalling" EXACT [] +is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling + +[Term] +id: GO:0009939 +name: positive regulation of gibberellic acid mediated signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] +synonym: "activation of gibberellic acid mediated signaling" NARROW [] +synonym: "positive regulation of gibberellic acid mediated signalling" EXACT [] +synonym: "stimulation of gibberellic acid mediated signaling" NARROW [] +synonym: "up regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "up-regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "upregulation of gibberellic acid mediated signaling" EXACT [] +is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling + +[Term] +id: GO:0009940 +name: amino-terminal vacuolar sorting propeptide binding +namespace: molecular_function +def: "Interacting selectively with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin coated vesicles." [GOC:sm, PMID:10871276] +is_a: GO:0010209 ! vacuolar sorting signal binding + +[Term] +id: GO:0009941 +name: chloroplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] +is_a: GO:0009526 ! plastid envelope +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0009942 +name: longitudinal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb] +synonym: "apical-basal pattern specification" EXACT [] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy + +[Term] +id: GO:0009943 +name: adaxial/abaxial axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009955 ! adaxial/abaxial pattern formation + +[Term] +id: GO:0009944 +name: polarity specification of adaxial/abaxial axis +namespace: biological_process +def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] +is_a: GO:0010084 ! specification of organ axis polarity +relationship: part_of GO:0009943 ! adaxial/abaxial axis specification + +[Term] +id: GO:0009945 +name: radial axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009956 ! radial pattern formation + +[Term] +id: GO:0009946 +name: proximal/distal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "proximodistal axis specification" EXACT [] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009954 ! proximal/distal pattern formation + +[Term] +id: GO:0009947 +name: centrolateral axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:tb, ISBN:0865427429] +is_a: GO:0009798 ! axis specification + +[Term] +id: GO:0009948 +name: anterior/posterior axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009952 ! anterior/posterior pattern formation + +[Term] +id: GO:0009949 +name: polarity specification of anterior/posterior axis +namespace: biological_process +def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0009950 +name: dorsal/ventral axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009953 ! dorsal/ventral pattern formation + +[Term] +id: GO:0009951 +name: polarity specification of dorsal/ventral axis +namespace: biological_process +def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0009952 +name: anterior/posterior pattern formation +namespace: biological_process +def: "The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] +synonym: "anterior/posterior pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009953 +name: dorsal/ventral pattern formation +namespace: biological_process +def: "The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] +synonym: "dorsal/ventral pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009954 +name: proximal/distal pattern formation +namespace: biological_process +def: "The regionalization process by which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] +synonym: "proximal/distal pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009955 +name: adaxial/abaxial pattern formation +namespace: biological_process +def: "The regionalization process by which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "adaxial/abaxial pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009956 +name: radial pattern formation +namespace: biological_process +def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete] +synonym: "radial pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009957 +name: epidermal cell fate specification +namespace: biological_process +alt_id: GO:0043356 +def: "Process by which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm] +synonym: "epidermal cell fate specification (sensu Insecta)" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0009958 +name: positive gravitropism +namespace: biological_process +def: "The orientation of plant parts towards gravity." [GOC:sm] +synonym: "root gravitropism" NARROW [] +is_a: GO:0009630 ! gravitropism + +[Term] +id: GO:0009959 +name: negative gravitropism +namespace: biological_process +def: "The orientation of plant parts away from gravity." [GOC:sm] +synonym: "shoot gravitropism" NARROW [] +is_a: GO:0009630 ! gravitropism + +[Term] +id: GO:0009960 +name: endosperm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0009961 +name: response to 1-aminocyclopropane-1-carboxylic acid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0009962 +name: regulation of flavonoid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] +subset: gosubset_prok +synonym: "regulation of flavonoid anabolism" EXACT [] +synonym: "regulation of flavonoid biosynthesis" EXACT [] +synonym: "regulation of flavonoid formation" EXACT [] +synonym: "regulation of flavonoid synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0009963 +name: positive regulation of flavonoid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] +subset: gosubset_prok +synonym: "activation of flavonoid biosynthetic process" NARROW [] +synonym: "positive regulation of flavonoid anabolism" EXACT [] +synonym: "positive regulation of flavonoid biosynthesis" EXACT [] +synonym: "positive regulation of flavonoid formation" EXACT [] +synonym: "positive regulation of flavonoid synthesis" EXACT [] +synonym: "stimulation of flavonoid biosynthetic process" NARROW [] +synonym: "up regulation of flavonoid biosynthetic process" EXACT [] +synonym: "up-regulation of flavonoid biosynthetic process" EXACT [] +synonym: "upregulation of flavonoid biosynthetic process" EXACT [] +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0009964 +name: negative regulation of flavonoid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] +subset: gosubset_prok +synonym: "down regulation of flavonoid biosynthetic process" EXACT [] +synonym: "down-regulation of flavonoid biosynthetic process" EXACT [] +synonym: "downregulation of flavonoid biosynthetic process" EXACT [] +synonym: "inhibition of flavonoid biosynthetic process" NARROW [] +synonym: "negative regulation of flavonoid anabolism" EXACT [] +synonym: "negative regulation of flavonoid biosynthesis" EXACT [] +synonym: "negative regulation of flavonoid formation" EXACT [] +synonym: "negative regulation of flavonoid synthesis" EXACT [] +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0009965 +name: leaf morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the leaf are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0010016 ! shoot morphogenesis +relationship: part_of GO:0048366 ! leaf development + +[Term] +id: GO:0009966 +name: regulation of signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] +subset: gosubset_prok +is_a: GO:0010646 ! regulation of cell communication +relationship: regulates GO:0007165 ! signal transduction + +[Term] +id: GO:0009967 +name: positive regulation of signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] +subset: gosubset_prok +synonym: "activation of signal transduction" NARROW [] +synonym: "stimulation of signal transduction" NARROW [] +synonym: "up regulation of signal transduction" EXACT [] +synonym: "up-regulation of signal transduction" EXACT [] +synonym: "upregulation of signal transduction" EXACT [] +xref: Reactome:110518 +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0010647 ! positive regulation of cell communication +relationship: positively_regulates GO:0007165 ! signal transduction + +[Term] +id: GO:0009968 +name: negative regulation of signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction." [GOC:sm] +subset: gosubset_prok +synonym: "down regulation of signal transduction" EXACT [] +synonym: "down-regulation of signal transduction" EXACT [] +synonym: "downregulation of signal transduction" EXACT [] +synonym: "inhibition of signal transduction" NARROW [] +xref: Reactome:110485 +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0010648 ! negative regulation of cell communication +relationship: negatively_regulates GO:0007165 ! signal transduction + +[Term] +id: GO:0009969 +name: xyloglucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of 1->4-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-1->6 residues, which is present in the primary cell wall of most higher plants." [GOC:sm] +subset: gosubset_prok +synonym: "xyloglucan anabolism" EXACT [] +synonym: "xyloglucan biosynthesis" EXACT [] +synonym: "xyloglucan formation" EXACT [] +synonym: "xyloglucan synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process + +[Term] +id: GO:0009970 +name: cellular response to sulfate starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm] +synonym: "cellular response to sulphate starvation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0009971 +name: anastral spindle assembly involved in male meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] +synonym: "male meiotic spindle assembly (sensu Viridiplantae)" EXACT [] +is_a: GO:0055048 ! anastral spindle assembly +relationship: part_of GO:0007140 ! male meiosis + +[Term] +id: GO:0009972 +name: cytidine deamination +namespace: biological_process +def: "The removal of amino group in the presence of water." [GOC:sm] +subset: gosubset_prok +is_a: GO:0006216 ! cytidine catabolic process + +[Term] +id: GO:0009973 +name: adenylyl-sulfate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + SO3(2-) (sulfite) + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] +subset: gosubset_prok +synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2] +synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2] +synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2] +synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] +synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] +synonym: "APS reductase activity" EXACT [EC:1.8.99.2] +synonym: "APS-reductase" EXACT [EC:1.8.99.2] +xref: EC:1.8.99.2 +xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0009974 +name: epsilon hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of zeinoxanthin to lutein. Adds hydroxy group to the epsilon ring of the alpha-carotene." [PMID:8837513] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0009975 +name: cyclase activity +namespace: molecular_function +def: "Catalysis of a ring closure reaction." [ISBN:0198547684] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0009976 +name: tocopherol cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0009977 +name: proton motive force dependent protein transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of proteins from one side of the membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245] +synonym: "delta-pH-dependent protein transporter activity" EXACT [] +synonym: "pH-dependent protein transporter activity" EXACT [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity + +[Term] +id: GO:0009978 +name: allene oxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] +synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] +synonym: "HPI" RELATED [EC:4.2.1.92] +synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] +synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] +xref: MetaCyc:RXN1F-19 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0009979 +name: 16:0 monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +is_a: GO:0042389 ! omega-3 fatty acid desaturase activity + +[Term] +id: GO:0009980 +name: glutamate carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +subset: gosubset_prok +synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] +synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] +synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] +synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] +synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] +xref: EC:3.4.17.11 +xref: MetaCyc:3.4.17.11-RXN +is_obsolete: true +replaced_by: GO:0004180 + +[Term] +id: GO:0009982 +name: pseudouridine synthase activity +namespace: molecular_function +alt_id: GO:0016439 +def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] +comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. +subset: gosubset_prok +synonym: "transfer ribonucleate pseudouridine synthetase activity" NARROW [EC:5.4.99.12] +synonym: "transfer RNA pseudouridine synthetase activity" NARROW [EC:5.4.99.12] +synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12] +synonym: "tRNA-pseudouridine synthase activity" NARROW [] +synonym: "tRNA-pseudouridine synthase I activity" NARROW [] +synonym: "tRNA-uridine isomerase activity" NARROW [EC:5.4.99.12] +synonym: "tRNA-uridine uracilmutase activity" NARROW [EC:5.4.99.12] +xref: EC:5.4.99.12 +xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0009983 +name: tyrosine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0009984 +name: adenylate forming enzyme activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835] +comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP. +is_obsolete: true +consider: GO:0046033 + +[Term] +id: GO:0009985 +name: dihydroflavonol(thiole) lyase activity +namespace: molecular_function +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0009986 +name: cell surface +namespace: cellular_component +alt_id: GO:0009928 +alt_id: GO:0009929 +def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] +comment: Note that this term is intended to annotate gene products that are attached to the plasma membrane or cell wall. +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "cell associated" EXACT [] +synonym: "cell bound" EXACT [] +synonym: "cell surface (sensu Magnoliophyta)" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0009987 +name: cellular process +namespace: biological_process +alt_id: GO:0008151 +alt_id: GO:0050875 +def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "cell growth and/or maintenance" NARROW [] +synonym: "cell physiology" EXACT [] +synonym: "cellular physiological process" EXACT [] +is_a: GO:0008150 ! biological_process +disjoint_from: GO:0032501 ! multicellular organismal process +disjoint_from: GO:0051704 ! multi-organism process + +[Term] +id: GO:0009988 +name: cell-cell recognition +namespace: biological_process +def: "Cell recognition between cells, usually involving the formation of specialized cell junctions." [ISBN:0824072820] +is_a: GO:0008037 ! cell recognition + +[Term] +id: GO:0009989 +name: cell-matrix recognition +namespace: biological_process +def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820] +is_a: GO:0008037 ! cell recognition + +[Term] +id: GO:0009990 +name: contact guidance +namespace: biological_process +def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820] +is_a: GO:0009989 ! cell-matrix recognition + +[Term] +id: GO:0009991 +name: response to extracellular stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0009992 +name: cellular water homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of water within a cell." [GOC:dph, GOC:tb] +synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006884 ! cell volume homeostasis +is_a: GO:0030104 ! water homeostasis + +[Term] +id: GO:0009994 +name: oocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] +synonym: "oocyte cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0009995 +name: soluble molecule recognition +namespace: biological_process +def: "The recognition of soluble molecules in the environment." [GOC:go_curators] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0009996 +name: negative regulation of cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] +synonym: "down regulation of cell fate specification" EXACT [] +synonym: "down-regulation of cell fate specification" EXACT [] +synonym: "downregulation of cell fate specification" EXACT [] +synonym: "inhibition of cell fate specification" NARROW [] +synonym: "suppression of cell fate" EXACT [] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0042659 ! regulation of cell fate specification +relationship: negatively_regulates GO:0001708 ! cell fate specification + +[Term] +id: GO:0009997 +name: negative regulation of cardioblast cell fate specification +namespace: biological_process +alt_id: GO:0042687 +def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast." [GOC:go_curators] +synonym: "down regulation of cardioblast cell fate specification" EXACT [] +synonym: "down-regulation of cardioblast cell fate specification" EXACT [] +synonym: "downregulation of cardioblast cell fate specification" EXACT [] +synonym: "inhibition of cardioblast cell fate specification" NARROW [] +synonym: "suppression of cardioblast cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042686 ! regulation of cardioblast cell fate specification +relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification + +[Term] +id: GO:0009998 +name: negative regulation of retinal cone cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators] +synonym: "down regulation of retinal cone cell fate specification" EXACT [] +synonym: "down-regulation of retinal cone cell fate specification" EXACT [] +synonym: "downregulation of retinal cone cell fate specification" EXACT [] +synonym: "inhibition of retinal cone cell fate specification" NARROW [] +synonym: "negative regulation of retina cone cell fate specification" EXACT [] +synonym: "suppression of retina cone cell fate" EXACT [] +synonym: "suppression of retinal cone cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042673 ! regulation of retinal cone cell fate specification +relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification + +[Term] +id: GO:0009999 +name: negative regulation of auditory receptor cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators] +synonym: "down regulation of auditory receptor cell fate specification" EXACT [] +synonym: "down-regulation of auditory receptor cell fate specification" EXACT [] +synonym: "downregulation of auditory receptor cell fate specification" EXACT [] +synonym: "inhibition of auditory receptor cell fate specification" NARROW [] +synonym: "negative regulation of auditory hair cell fate specification" EXACT [] +synonym: "suppression of auditory receptor cell fate" EXACT [] +synonym: "suppression of hair cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042669 ! regulation of auditory receptor cell fate specification +relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification + +[Term] +id: GO:0010001 +name: glial cell differentiation +namespace: biological_process +alt_id: GO:0007404 +alt_id: GO:0043360 +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] +synonym: "glia cell differentiation" EXACT [] +synonym: "glial cell differentiation (sensu Nematoda and Protostomia)" EXACT [] +synonym: "neuroglia differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0010002 +name: cardioblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast." [GOC:go_curators] +synonym: "cardioblast cell differentiation" EXACT [] +synonym: "cardiomyocyte generation" RELATED [] +is_a: GO:0035051 ! cardiac cell differentiation + +[Term] +id: GO:0010004 +name: gastrulation involving germ band extension +namespace: biological_process +def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development." [GOC:go_curators, GOC:mtg_sensu] +synonym: "gastrulation (sensu Insecta)" EXACT [] +is_a: GO:0001703 ! gastrulation with mouth forming first + +[Term] +id: GO:0010005 +name: cortical microtubule, transverse to long axis +namespace: cellular_component +def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] +synonym: "cortical microtubule (sensu Viridiplantae)" EXACT [] +is_a: GO:0055028 ! cortical microtubule + +[Term] +id: GO:0010006 +name: Toc complex +namespace: cellular_component +def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0010007 +name: magnesium chelatase complex +namespace: cellular_component +def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] +is_a: GO:0043234 ! protein complex +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0010008 +name: endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an endosome." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044440 ! endosomal part + +[Term] +id: GO:0010009 +name: external side of endosome membrane +namespace: cellular_component +def: "The external (cytoplasmic face) of an endosome membrane." [GOC:lr] +is_a: GO:0044425 ! membrane part +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0010011 +name: auxin binding +namespace: molecular_function +def: "Interacting selectively with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm] +synonym: "auxin receptor" NARROW [] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0010012 +name: steroid 22-alpha hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0010013 +name: N-1-naphthylphthalamic acid binding +namespace: molecular_function +def: "Interacting selectively with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0010014 +name: meristem initiation +namespace: biological_process +def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009933 ! meristem structural organization + +[Term] +id: GO:0010015 +name: root morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of roots are generated and organized. Morphogenesis pertains to the creation of form. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0010016 +name: shoot morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the shoot are generated and organized. Morphogenesis pertains to the creation of form. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048367 ! shoot development + +[Term] +id: GO:0010017 +name: red or far red light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] +synonym: "phytochrome signaling pathway" BROAD [] +synonym: "red or far red light signalling pathway" EXACT [] +synonym: "red/far red light signaling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0010018 +name: far red light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] +synonym: "far red light signalling pathway" EXACT [] +is_a: GO:0010017 ! red or far red light signaling pathway +is_a: GO:0010218 ! response to far red light + +[Term] +id: GO:0010019 +name: chloroplast-nucleus signaling pathway +namespace: biological_process +def: "The process by which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595] +synonym: "chloroplast-nucleus signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0010020 +name: chloroplast fission +namespace: biological_process +def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] +synonym: "chloroplast division" EXACT [] +is_a: GO:0009658 ! chloroplast organization +is_a: GO:0043572 ! plastid fission + +[Term] +id: GO:0010021 +name: amylopectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1,4) linked alpha glucose units with alpha-(1,6) linkages." [ISBN:0943088399] +subset: gosubset_prok +synonym: "amylopectin anabolism" EXACT [] +synonym: "amylopectin biosynthesis" EXACT [] +synonym: "amylopectin formation" EXACT [] +synonym: "amylopectin synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0019252 ! starch biosynthetic process + +[Term] +id: GO:0010022 +name: meristem determinacy +namespace: biological_process +def: "The process by which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0010073 ! meristem maintenance + +[Term] +id: GO:0010023 +name: proanthocyanidin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm] +subset: gosubset_prok +synonym: "proanthocyanidin anabolism" EXACT [] +synonym: "proanthocyanidin biosynthesis" EXACT [] +synonym: "proanthocyanidin formation" EXACT [] +synonym: "proanthocyanidin synthesis" EXACT [] +xref: MetaCyc:PWY-641 +is_a: GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0010024 +name: phytochromobilin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195] +subset: gosubset_prok +synonym: "phytochromobilin anabolism" EXACT [] +synonym: "phytochromobilin biosynthesis" EXACT [] +synonym: "phytochromobilin formation" EXACT [] +synonym: "phytochromobilin synthesis" EXACT [] +is_a: GO:0051188 ! cofactor biosynthetic process +is_a: GO:0051202 ! phytochromobilin metabolic process + +[Term] +id: GO:0010025 +name: wax biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] +subset: gosubset_prok +synonym: "wax anabolism" EXACT [] +synonym: "wax biosynthesis" EXACT [] +synonym: "wax formation" EXACT [] +synonym: "wax synthesis" EXACT [] +xref: MetaCyc:PWY-282 +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0010166 ! wax metabolic process + +[Term] +id: GO:0010026 +name: trichome differentiation +namespace: biological_process +alt_id: GO:0048271 +def: "The process whereby a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell." [GOC:mtg_sensu, PMID:9367433] +synonym: "trichome cell differentiation (sensu Magnoliophyta)" EXACT [] +synonym: "trichome differentiation (sensu Magnoliophyta)" EXACT [] +is_a: GO:0035315 ! hair cell differentiation +relationship: part_of GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0010027 +name: thylakoid membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb] +comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'. +synonym: "thylakoid membrane organisation and biogenesis" EXACT [] +synonym: "thylakoid membrane organization and biogenesis" EXACT [] +is_a: GO:0009668 ! plastid membrane organization + +[Term] +id: GO:0010028 +name: xanthophyll cycle +namespace: biological_process +def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743] +subset: gosubset_prok +xref: MetaCyc:PWY-1141 +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0010029 +name: regulation of seed germination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0009845 ! seed germination + +[Term] +id: GO:0010030 +name: positive regulation of seed germination +namespace: biological_process +def: "Any process that activates or increase the rate of seed germination." [GOC:sm] +synonym: "activation of seed germination" NARROW [] +synonym: "stimulation of seed germination" NARROW [] +synonym: "up regulation of seed germination" EXACT [] +synonym: "up-regulation of seed germination" EXACT [] +synonym: "upregulation of seed germination" EXACT [] +is_a: GO:0010029 ! regulation of seed germination +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0009845 ! seed germination + +[Term] +id: GO:0010031 +name: circumnutation +namespace: biological_process +def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023] +is_a: GO:0050879 ! multicellular organismal movement + +[Term] +id: GO:0010032 +name: meiotic chromosome condensation +namespace: biological_process +def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] +is_a: GO:0030261 ! chromosome condensation + +[Term] +id: GO:0010033 +name: response to organic substance +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm] +subset: gosubset_prok +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0010034 +name: response to acetate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] +subset: gosubset_prok +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0010035 +name: response to inorganic substance +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] +subset: gosubset_prok +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0010036 +name: response to boron +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron stimulus." [GOC:sm] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010037 +name: response to carbon dioxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010038 +name: response to metal ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] +subset: gosubset_prok +synonym: "heavy metal sensitivity/resistance" RELATED [] +synonym: "response to heavy metal" NARROW [] +synonym: "response to metal" EXACT [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010039 +name: response to iron ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] +synonym: "response to iron" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010040 +name: response to iron(II) ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm] +synonym: "response to iron(II)" EXACT [] +is_a: GO:0010039 ! response to iron ion + +[Term] +id: GO:0010041 +name: response to iron(III) ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm] +synonym: "response to iron(III)" EXACT [] +is_a: GO:0010039 ! response to iron ion + +[Term] +id: GO:0010042 +name: response to manganese ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] +synonym: "response to manganese" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010043 +name: response to zinc ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] +synonym: "response to zinc" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010044 +name: response to aluminum ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm] +synonym: "response to aluminium ion" EXACT [] +synonym: "response to aluminum" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010045 +name: response to nickel ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:sm] +synonym: "response to nickel" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010046 +name: response to mycotoxin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin are a toxic chemical substance produced by fungi." [GOC:sm] +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0010047 +name: fruit dehiscence +namespace: biological_process +def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208] +is_a: GO:0009900 ! dehiscence + +[Term] +id: GO:0010048 +name: vernalization response +namespace: biological_process +def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392] +is_a: GO:0009409 ! response to cold + +[Term] +id: GO:0010049 +name: acquisition of reproductive competence +namespace: biological_process +def: "The process by which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0010050 +name: vegetative phase change +namespace: biological_process +def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0010051 +name: xylem and phloem pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the patterning of the conducting tissues." [GOC:mtg_sensu, GOC:tb] +synonym: "vascular tissue pattern formation (sensu Tracheophyta)" EXACT [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0010052 +name: guard cell differentiation +namespace: biological_process +def: "The process whereby a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb] +synonym: "stomatal cell differentiation" RELATED [] +is_a: GO:0009913 ! epidermal cell differentiation +relationship: part_of GO:0010103 ! stomatal complex morphogenesis + +[Term] +id: GO:0010053 +name: root epidermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb] +is_a: GO:0009913 ! epidermal cell differentiation +relationship: part_of GO:0010015 ! root morphogenesis + +[Term] +id: GO:0010054 +name: trichoblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb] +synonym: "trichoblast cell differentiation" EXACT [] +is_a: GO:0010053 ! root epidermal cell differentiation + +[Term] +id: GO:0010055 +name: atrichoblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb] +is_a: GO:0010053 ! root epidermal cell differentiation + +[Term] +id: GO:0010056 +name: atrichoblast fate specification +namespace: biological_process +def: "The process involved in the specification of an atrichoblast." [GOC:tb] +is_a: GO:0009957 ! epidermal cell fate specification +relationship: part_of GO:0010055 ! atrichoblast differentiation + +[Term] +id: GO:0010057 +name: trichoblast fate specification +namespace: biological_process +def: "The process involved in the specification of a trichoblast." [GOC:tb] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0010054 ! trichoblast differentiation + +[Term] +id: GO:0010058 +name: regulation of atrichoblast fate specification +namespace: biological_process +def: "Any process that modulates atrichoblast fate specification." [GOC:tb] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0045604 ! regulation of epidermal cell differentiation +relationship: regulates GO:0010056 ! atrichoblast fate specification + +[Term] +id: GO:0010059 +name: positive regulation of atrichoblast fate specification +namespace: biological_process +def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb] +synonym: "activation of atrichoblast fate" NARROW [] +synonym: "stimulation of atrichoblast fate" NARROW [] +synonym: "up regulation of atrichoblast fate" EXACT [] +synonym: "up-regulation of atrichoblast fate" EXACT [] +synonym: "upregulation of atrichoblast fate" EXACT [] +is_a: GO:0010058 ! regulation of atrichoblast fate specification +is_a: GO:0042660 ! positive regulation of cell fate specification +relationship: positively_regulates GO:0010056 ! atrichoblast fate specification + +[Term] +id: GO:0010060 +name: negative regulation of atrichoblast fate specification +namespace: biological_process +def: "Any process that suppresses atrichoblast fate specification." [GOC:tb] +synonym: "down regulation of atrichoblast fate" EXACT [] +synonym: "down-regulation of atrichoblast fate" EXACT [] +synonym: "downregulation of atrichoblast fate" EXACT [] +synonym: "inhibition of atrichoblast fate" NARROW [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0010058 ! regulation of atrichoblast fate specification +relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification + +[Term] +id: GO:0010061 +name: regulation of trichoblast fate specification +namespace: biological_process +def: "Any process that modulates trichoblast fate specification." [GOC:tb] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0045604 ! regulation of epidermal cell differentiation +relationship: regulates GO:0010057 ! trichoblast fate specification + +[Term] +id: GO:0010062 +name: negative regulation of trichoblast fate specification +namespace: biological_process +def: "Any process that suppresses trichoblast fate specification." [GOC:tb] +synonym: "down regulation of trichoblast fate" EXACT [] +synonym: "down-regulation of trichoblast fate" EXACT [] +synonym: "downregulation of trichoblast fate" EXACT [] +synonym: "inhibition of trichoblast fate" NARROW [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0010061 ! regulation of trichoblast fate specification +relationship: negatively_regulates GO:0010057 ! trichoblast fate specification + +[Term] +id: GO:0010063 +name: positive regulation of trichoblast fate specification +namespace: biological_process +def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb] +synonym: "activation of trichoblast fate" NARROW [] +synonym: "stimulation of trichoblast fate" NARROW [] +synonym: "up regulation of trichoblast fate" EXACT [] +synonym: "up-regulation of trichoblast fate" EXACT [] +synonym: "upregulation of trichoblast fate" EXACT [] +is_a: GO:0010061 ! regulation of trichoblast fate specification +is_a: GO:0042660 ! positive regulation of cell fate specification +relationship: positively_regulates GO:0010057 ! trichoblast fate specification + +[Term] +id: GO:0010064 +name: embryonic shoot morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of embryonic shoot are generated and organized. Morphogenesis pertains to the creation of form." [GOC:tb] +is_a: GO:0010016 ! shoot morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0010065 +name: primary meristem tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208] +synonym: "primary meristem histogenesis" EXACT [] +is_a: GO:0048508 ! embryonic meristem development + +[Term] +id: GO:0010066 +name: ground meristem histogenesis +namespace: biological_process +def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208] +is_a: GO:0010065 ! primary meristem tissue development + +[Term] +id: GO:0010067 +name: procambium histogenesis +namespace: biological_process +def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208] +is_a: GO:0010065 ! primary meristem tissue development + +[Term] +id: GO:0010068 +name: protoderm histogenesis +namespace: biological_process +def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208] +is_a: GO:0010065 ! primary meristem tissue development + +[Term] +id: GO:0010069 +name: zygote asymmetric cytokinesis in the embryo sac +namespace: biological_process +def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] +synonym: "zygote asymmetric cytokinesis (sensu Magnoliophyta)" EXACT [] +is_a: GO:0010070 ! zygote asymmetric cell division +is_a: GO:0033205 ! cytokinesis during cell cycle +relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy + +[Term] +id: GO:0010070 +name: zygote asymmetric cell division +namespace: biological_process +def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] +synonym: "zygote asymmetric cytokinesis" RELATED [] +is_a: GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0010071 +name: root meristem specification +namespace: biological_process +def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:tb] +is_a: GO:0009942 ! longitudinal axis specification +is_a: GO:0048508 ! embryonic meristem development +relationship: part_of GO:0010015 ! root morphogenesis + +[Term] +id: GO:0010072 +name: primary shoot apical meristem specification +namespace: biological_process +def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:tair_curators] +is_a: GO:0009942 ! longitudinal axis specification +is_a: GO:0048508 ! embryonic meristem development +relationship: part_of GO:0010016 ! shoot morphogenesis + +[Term] +id: GO:0010073 +name: meristem maintenance +namespace: biological_process +def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0048507 ! meristem development + +[Term] +id: GO:0010074 +name: maintenance of meristem identity +namespace: biological_process +alt_id: GO:0032503 +def: "The process by which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb] +synonym: "maintenance of meristem cell identity" EXACT [] +synonym: "meristem cell maintenance" EXACT [] +is_a: GO:0019827 ! stem cell maintenance +relationship: part_of GO:0010073 ! meristem maintenance + +[Term] +id: GO:0010075 +name: regulation of meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb] +synonym: "regulation of meristem size" EXACT [GOC:tb] +is_a: GO:0048509 ! regulation of meristem development +is_a: GO:0048638 ! regulation of developmental growth +relationship: part_of GO:0010073 ! meristem maintenance +relationship: regulates GO:0035266 ! meristem growth + +[Term] +id: GO:0010076 +name: maintenance of floral meristem identity +namespace: biological_process +def: "The process by which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010077 +name: maintenance of inflorescence meristem identity +namespace: biological_process +def: "The process by which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010078 +name: maintenance of root meristem identity +namespace: biological_process +def: "The process by which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity +relationship: part_of GO:0010015 ! root morphogenesis + +[Term] +id: GO:0010079 +name: maintenance of vegetative meristem identity +namespace: biological_process +def: "The process by which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010080 +name: regulation of floral meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb] +synonym: "regulation of floral meristem size" EXACT [] +is_a: GO:0009909 ! regulation of flower development +is_a: GO:0010075 ! regulation of meristem growth +relationship: regulates GO:0010451 ! floral meristem growth + +[Term] +id: GO:0010081 +name: regulation of inflorescence meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb] +synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0010450 ! inflorescence meristem growth + +[Term] +id: GO:0010082 +name: regulation of root meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb] +synonym: "regulation of root meristem size" EXACT [GOC:tb] +is_a: GO:0010075 ! regulation of meristem growth +relationship: part_of GO:0010015 ! root morphogenesis +relationship: regulates GO:0010449 ! root meristem growth + +[Term] +id: GO:0010083 +name: regulation of vegetative meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb] +synonym: "regulation of vegetative meristem size" EXACT [GOC:tb] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:0048831 ! regulation of shoot development +relationship: regulates GO:0010448 ! vegetative meristem growth + +[Term] +id: GO:0010084 +name: specification of organ axis polarity +namespace: biological_process +def: "The process by which the polarity of an organ axis is specified." [GOC:tb] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0010085 +name: polarity specification of proximal/distal axis +namespace: biological_process +def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb] +is_a: GO:0010084 ! specification of organ axis polarity +relationship: part_of GO:0009946 ! proximal/distal axis specification + +[Term] +id: GO:0010086 +name: embryonic root morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the embryonic root are generated and organized. Morphogenesis pertains to the creation of form." [GOC:tb] +is_a: GO:0010015 ! root morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0010087 +name: phloem or xylem histogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure." [GOC:mtg_sensu, GOC:tb] +synonym: "phloem or xylem development" EXACT [] +synonym: "vascular tissue development (sensu Tracheophyta)" EXACT [] +synonym: "vascular tissue histogenesis (sensu Tracheophyta)" EXACT [] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0010088 +name: phloem histogenesis +namespace: biological_process +def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] +is_a: GO:0010087 ! phloem or xylem histogenesis + +[Term] +id: GO:0010089 +name: xylem histogenesis +namespace: biological_process +def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] +is_a: GO:0010087 ! phloem or xylem histogenesis + +[Term] +id: GO:0010090 +name: trichome morphogenesis +namespace: biological_process +alt_id: GO:0048272 +def: "The process by which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell." [GOC:mtg_sensu, GOC:tair_curators] +synonym: "trichome cell morphogenesis during differentiation (sensu Magnoliophyta)" EXACT [] +synonym: "trichome morphogenesis (sensu Magnoliophyta)" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0010026 ! trichome differentiation + +[Term] +id: GO:0010091 +name: trichome branching +namespace: biological_process +alt_id: GO:0048274 +def: "Any process involved in the formation of branches in plant hair cells." [GOC:mtg_sensu, GOC:tair_curators] +synonym: "trichome branching (sensu Magnoliophyta)" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0010090 ! trichome morphogenesis + +[Term] +id: GO:0010092 +name: specification of organ identity +namespace: biological_process +def: "The regionalization process by which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0010093 +name: specification of floral organ identity +namespace: biological_process +def: "The process by which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0010092 ! specification of organ identity +relationship: part_of GO:0048444 ! floral organ morphogenesis + +[Term] +id: GO:0010094 +name: specification of carpel identity +namespace: biological_process +def: "The process by which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048462 ! carpel formation + +[Term] +id: GO:0010095 +name: specification of petal identity +namespace: biological_process +def: "The process by which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048451 ! petal formation + +[Term] +id: GO:0010096 +name: specification of sepal identity +namespace: biological_process +def: "The process by which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048453 ! sepal formation + +[Term] +id: GO:0010097 +name: specification of stamen identity +namespace: biological_process +def: "The process by which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048455 ! stamen formation + +[Term] +id: GO:0010098 +name: suspensor development +namespace: biological_process +def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0010099 +name: regulation of photomorphogenesis +namespace: biological_process +def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009640 ! photomorphogenesis + +[Term] +id: GO:0010100 +name: negative regulation of photomorphogenesis +namespace: biological_process +def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb] +synonym: "down regulation of photomorphogenesis" EXACT [] +synonym: "down-regulation of photomorphogenesis" EXACT [] +synonym: "downregulation of photomorphogenesis" EXACT [] +synonym: "inhibition of photomorphogenesis" NARROW [] +is_a: GO:0010099 ! regulation of photomorphogenesis +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009640 ! photomorphogenesis + +[Term] +id: GO:0010101 +name: post-embryonic root morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the post-embryonic root are generated and organized. Morphogenesis pertains to the creation of form. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb] +is_a: GO:0009886 ! post-embryonic morphogenesis +is_a: GO:0010015 ! root morphogenesis +relationship: part_of GO:0048528 ! post-embryonic root development + +[Term] +id: GO:0010102 +name: lateral root morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of lateral root are generated and organized. Morphogenesis pertains to the creation of form. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators] +is_a: GO:0010101 ! post-embryonic root morphogenesis +relationship: part_of GO:0048527 ! lateral root development + +[Term] +id: GO:0010103 +name: stomatal complex morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the stomatal complex are generated and organized. Morphogenesis pertains to the creation of form. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0010016 ! shoot morphogenesis +relationship: part_of GO:0010374 ! stomatal complex development + +[Term] +id: GO:0010104 +name: regulation of ethylene mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) mediated signaling." [GOC:tb] +synonym: "regulation of ethene mediated signaling pathway" EXACT [] +synonym: "regulation of ethene mediated signalling pathway" EXACT [] +synonym: "regulation of ethylene mediated signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009873 ! ethylene mediated signaling pathway + +[Term] +id: GO:0010105 +name: negative regulation of ethylene mediated signaling pathway +namespace: biological_process +def: "Any process that stops or prevents ethylene (ethene) mediated signaling." [GOC:tb] +synonym: "down regulation of ethylene mediated signaling pathway" EXACT [] +synonym: "down-regulation of ethylene mediated signaling pathway" EXACT [] +synonym: "downregulation of ethylene mediated signaling pathway" EXACT [] +synonym: "inhibition of ethylene mediated signaling pathway" NARROW [] +synonym: "negative regulation of ethene mediated signaling pathway" EXACT [] +synonym: "negative regulation of ethene mediated signalling pathway" EXACT [] +synonym: "negative regulation of ethylene mediated signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010104 ! regulation of ethylene mediated signaling pathway +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009873 ! ethylene mediated signaling pathway + +[Term] +id: GO:0010106 +name: cellular response to iron ion starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0010107 +name: potassium ion import +namespace: biological_process +def: "The directed movement of potassium ions into a cell or organelle." [GOC:sm] +synonym: "potassium import" EXACT [] +synonym: "potassium ion uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006813 ! potassium ion transport + +[Term] +id: GO:0010108 +name: detection of glutamine +namespace: biological_process +def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "glutamine detection" EXACT [] +synonym: "glutamine perception" RELATED [] +synonym: "glutamine sensing" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0010109 +name: regulation of photosynthesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] +subset: gosubset_prok +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0015979 ! photosynthesis + +[Term] +id: GO:0010110 +name: regulation of photosynthesis, dark reaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm] +is_a: GO:0010109 ! regulation of photosynthesis +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0019685 ! photosynthesis, dark reaction + +[Term] +id: GO:0010111 +name: glyoxysome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb] +synonym: "glyoxysome organisation and biogenesis" EXACT [] +synonym: "glyoxysome organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0010112 +name: regulation of systemic acquired resistance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0043900 ! regulation of multi-organism process +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:0010113 +name: negative regulation of systemic acquired resistance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm] +synonym: "down regulation of systemic acquired resistance" EXACT [] +synonym: "down-regulation of systemic acquired resistance" EXACT [] +synonym: "downregulation of systemic acquired resistance" EXACT [] +synonym: "inhibition of systemic acquired resistance" NARROW [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0010112 ! regulation of systemic acquired resistance +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:0010114 +name: response to red light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] +synonym: "response to red light stimulus" EXACT [] +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0010115 +name: regulation of abscisic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] +subset: gosubset_prok +synonym: "regulation of abscisic acid anabolism" EXACT [] +synonym: "regulation of abscisic acid biosynthesis" EXACT [] +synonym: "regulation of abscisic acid formation" EXACT [] +synonym: "regulation of abscisic acid synthesis" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0009688 ! abscisic acid biosynthetic process + +[Term] +id: GO:0010116 +name: positive regulation of abscisic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] +subset: gosubset_prok +synonym: "activation of abscisic acid biosynthetic process" NARROW [] +synonym: "positive regulation of abscisic acid anabolism" EXACT [] +synonym: "positive regulation of abscisic acid biosynthesis" EXACT [] +synonym: "positive regulation of abscisic acid formation" EXACT [] +synonym: "positive regulation of abscisic acid synthesis" EXACT [] +synonym: "stimulation of abscisic acid biosynthetic process" NARROW [] +synonym: "up regulation of abscisic acid biosynthetic process" EXACT [] +synonym: "up-regulation of abscisic acid biosynthetic process" EXACT [] +synonym: "upregulation of abscisic acid biosynthetic process" EXACT [] +is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process + +[Term] +id: GO:0010117 +name: photoprotection +namespace: biological_process +def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0010118 +name: stomatal movement +namespace: biological_process +def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0010119 +name: regulation of stomatal movement +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0010118 ! stomatal movement + +[Term] +id: GO:0010120 +name: camalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz] +synonym: "camalexin anabolism" EXACT [] +synonym: "camalexin biosynthesis" EXACT [] +synonym: "camalexin formation" EXACT [] +synonym: "camalexin synthesis" EXACT [] +xref: MetaCyc:CAMALEXIN-SYN +is_a: GO:0009700 ! indole phytoalexin biosynthetic process +is_a: GO:0052317 ! camalexin metabolic process + +[Term] +id: GO:0010121 +name: arginine catabolic process to proline via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz] +subset: gosubset_prok +synonym: "arginine breakdown to proline via ornithine" EXACT [] +synonym: "arginine degradation to proline via ornithine" EXACT [] +xref: MetaCyc:ARGORNPROST-PWY +is_a: GO:0019493 ! arginine catabolic process to proline + +[Term] +id: GO:0010122 +name: arginine catabolic process to alanine via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz] +subset: gosubset_prok +synonym: "arginine breakdown to alanine via ornithine" EXACT [] +synonym: "arginine degradation to alanine via ornithine" EXACT [] +xref: MetaCyc:ARGORNPROST-PWY +is_a: GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0010123 +name: acetate catabolic process to butyrate, ethanol, acetone and butanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz] +subset: gosubset_prok +synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT [] +xref: MetaCyc:CENTFERM-PWY +is_a: GO:0019654 ! acetate fermentation + +[Term] +id: GO:0010124 +name: phenylacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz] +subset: gosubset_prok +synonym: "phenylacetate breakdown" EXACT [] +synonym: "phenylacetate catabolism" EXACT [] +synonym: "phenylacetate degradation" EXACT [] +xref: MetaCyc:PWY0-321 +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0010125 +name: mycothiol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] +subset: gosubset_prok +synonym: "mycothiol anabolism" EXACT [] +synonym: "mycothiol biosynthesis" EXACT [] +synonym: "mycothiol formation" EXACT [] +synonym: "mycothiol synthesis" EXACT [] +xref: MetaCyc:PWY1G-0 +is_a: GO:0010126 ! mycothiol metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0010126 +name: mycothiol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] +subset: gosubset_prok +synonym: "mycothiol metabolism" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0010127 +name: mycothiol-dependent detoxification +namespace: biological_process +def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz] +synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW [] +xref: MetaCyc:PWY1G-1 +xref: MetaCyc:PWY1G-170 +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0010128 +name: benzoate catabolic process via CoA ligation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz] +subset: gosubset_prok +synonym: "anaerobic benzoate breakdown" EXACT [] +synonym: "anaerobic benzoate catabolic process" EXACT [] +synonym: "anaerobic benzoate catabolism" EXACT [] +synonym: "anaerobic benzoate degradation" EXACT [] +xref: MetaCyc:PWY-283 +is_a: GO:0018875 ! anaerobic benzoate metabolic process +is_a: GO:0043639 ! benzoate catabolic process + +[Term] +id: GO:0010129 +name: anaerobic cyclohexane-1-carboxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz] +subset: gosubset_prok +synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT [] +synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT [] +synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT [] +xref: MetaCyc:PWY-301 +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0010130 +name: anaerobic ethylbenzene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz] +subset: gosubset_prok +synonym: "anaerobic ethylbenzene breakdown" EXACT [] +synonym: "anaerobic ethylbenzene catabolism" EXACT [] +synonym: "anaerobic ethylbenzene degradation" EXACT [] +xref: MetaCyc:PWY-481 +is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0010131 +name: sucrose catabolic process, using invertase or sucrose synthase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz] +subset: gosubset_prok +synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT [] +synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT [] +synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT [] +xref: MetaCyc:PWY-3801 +xref: MetaCyc:PWY-621 +is_a: GO:0005987 ! sucrose catabolic process + +[Term] +id: GO:0010132 +name: dhurrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz] +subset: gosubset_prok +synonym: "dhurrin anabolism" EXACT [] +synonym: "dhurrin biosynthesis" EXACT [] +synonym: "dhurrin formation" EXACT [] +synonym: "dhurrin synthesis" EXACT [] +xref: MetaCyc:PWY-861 +is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process + +[Term] +id: GO:0010133 +name: proline catabolic process to glutamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] +subset: gosubset_prok +synonym: "proline breakdown to glutamate" EXACT [] +synonym: "proline degradation to glutamate" EXACT [] +xref: MetaCyc:PROUT-PWY +xref: MetaCyc:PWY-4561 +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006562 ! proline catabolic process + +[Term] +id: GO:0010134 +name: sulfate assimilation via adenylyl sulfate reduction +namespace: biological_process +def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] +subset: gosubset_prok +synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] +xref: MetaCyc:SULFMETII-PWY +is_a: GO:0000103 ! sulfate assimilation + +[Term] +id: GO:0010135 +name: ureide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz] +subset: gosubset_prok +synonym: "ureide metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0010136 +name: ureide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz] +subset: gosubset_prok +synonym: "ureide breakdown" EXACT [] +synonym: "ureide catabolism" EXACT [] +synonym: "ureide degradation" EXACT [] +xref: MetaCyc:URDEGR-PWY +is_a: GO:0010135 ! ureide metabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0010137 +name: ureide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz] +subset: gosubset_prok +synonym: "ureide anabolism" EXACT [] +synonym: "ureide biosynthesis" EXACT [] +synonym: "ureide formation" EXACT [] +synonym: "ureide synthesis" EXACT [] +xref: MetaCyc:URSIN-PWY +is_a: GO:0010135 ! ureide metabolic process +is_a: GO:0044271 ! nitrogen compound biosynthetic process + +[Term] +id: GO:0010138 +name: pyrimidine ribonucleotide salvage +namespace: biological_process +def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz] +subset: gosubset_prok +xref: MetaCyc:PWY0-163 +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process +is_a: GO:0032262 ! pyrimidine nucleotide salvage + +[Term] +id: GO:0010139 +name: pyrimidine deoxyribonucleotide salvage +namespace: biological_process +def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz] +subset: gosubset_prok +xref: MetaCyc:PWY0-181 +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0032262 ! pyrimidine nucleotide salvage + +[Term] +id: GO:0010140 +name: adenine, hypoxanthine and their nucleoside salvage +namespace: biological_process +def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz] +comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. +is_obsolete: true +replaced_by: GO:0006168 +replaced_by: GO:0006169 +replaced_by: GO:0006190 +replaced_by: GO:0043103 + +[Term] +id: GO:0010141 +name: guanine, xanthine and their nucleoside salvage +namespace: biological_process +def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz] +comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. +is_obsolete: true +replaced_by: GO:0006178 +replaced_by: GO:0006179 +replaced_by: GO:0006190 +replaced_by: GO:0043103 + +[Term] +id: GO:0010142 +name: farnesyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922] +subset: gosubset_prok +synonym: "Ac-MVA pathway" NARROW [PMID:14517367] +synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367] +synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT [] +synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT [] +synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT [] +synonym: "isoprenoid pathway" EXACT [] +xref: MetaCyc:PWY-922 +is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process +relationship: part_of GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0010143 +name: cutin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819] +subset: gosubset_prok +synonym: "cutin anabolism" EXACT [] +synonym: "cutin biosynthesis" EXACT [] +synonym: "cutin formation" EXACT [] +synonym: "cutin synthesis" EXACT [] +xref: MetaCyc:PWY-321 +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0010144 +name: pyridoxal phosphate biosynthetic process from pyridoxamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz] +subset: gosubset_prok +synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT [] +synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT [] +synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT [] +synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT [] +synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT [] +xref: MetaCyc:PYRIDOXAMINE+ANABOLISM +is_a: GO:0042818 ! pyridoxamine metabolic process +is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process + +[Term] +id: GO:0010145 +name: fructan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm] +subset: gosubset_prok +synonym: "fructan metabolism" EXACT [] +synonym: "levan metabolic process" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0010146 +name: fructan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz] +subset: gosubset_prok +synonym: "fructan anabolism" EXACT [] +synonym: "fructan biosynthesis" EXACT [] +synonym: "fructan formation" EXACT [] +synonym: "fructan synthesis" EXACT [] +synonym: "levan biosynthesis" EXACT [] +synonym: "levan biosynthetic process" EXACT [] +xref: MetaCyc:PWY-822 +is_a: GO:0010145 ! fructan metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0010147 +name: fructan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz] +subset: gosubset_prok +synonym: "fructan breakdown" EXACT [] +synonym: "fructan catabolism" EXACT [] +synonym: "fructan degradation" EXACT [] +synonym: "levan catabolic process" EXACT [] +synonym: "levan catabolism" EXACT [] +xref: MetaCyc:PWY-862 +is_a: GO:0010145 ! fructan metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0010148 +name: transpiration +namespace: biological_process +def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322] +is_a: GO:0006833 ! water transport + +[Term] +id: GO:0010149 +name: senescence +namespace: biological_process +def: "A preprogrammed process that occurs in an organism that is associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components." [GOC:mtg_sensu, ISBN:0387987819] +synonym: "senescence (sensu Magnoliophyta)" NARROW [] +is_a: GO:0007568 ! aging + +[Term] +id: GO:0010150 +name: leaf senescence +namespace: biological_process +def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819] +is_a: GO:0010260 ! organ senescence + +[Term] +id: GO:0010151 +name: chloroplast elongation +namespace: biological_process +def: "Expansion of the chloroplast that usually precedes division." [GOC:lr] +is_a: GO:0009658 ! chloroplast organization + +[Term] +id: GO:0010152 +name: pollen maturation +namespace: biological_process +def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0010153 +name: polar cell elongation +namespace: biological_process +def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864] +comment: This term was made obsolete because it did not represent a concept discrete from its sibling terms. +synonym: "polarity-dependent cell elongation" NARROW [] +is_obsolete: true +consider: GO:0042814 +consider: GO:0042815 + +[Term] +id: GO:0010154 +name: fruit development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0010155 +name: regulation of proton transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proton transport into, out of, within or between cells." [GOC:sm] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0015992 ! proton transport + +[Term] +id: GO:0010156 +name: sporocyte morphogenesis +namespace: biological_process +def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788] +comment: This term was made obsolete because it was incorrectly defined. +is_obsolete: true +consider: GO:0048533 + +[Term] +id: GO:0010157 +name: response to chlorate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010158 +name: abaxial cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] +is_a: GO:0001708 ! cell fate specification + +[Term] +id: GO:0010159 +name: specification of organ position +namespace: biological_process +def: "The regionalization process by which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ." [PMID:9611175] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0010160 +name: formation of organ boundary +namespace: biological_process +alt_id: GO:0048862 +def: "The regionalization process that specifies organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] +synonym: "organ boundary specification" EXACT [] +is_a: GO:0003002 ! regionalization +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0048645 ! organ formation + +[Term] +id: GO:0010161 +name: red light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] +synonym: "red light signalling pathway" EXACT [] +is_a: GO:0010017 ! red or far red light signaling pathway +is_a: GO:0010114 ! response to red light + +[Term] +id: GO:0010162 +name: seed dormancy +namespace: biological_process +def: "The process by which a dormant state is induced, maintained and broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated." [GOC:lr] +is_a: GO:0022611 ! dormancy process +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0010431 ! seed maturation + +[Term] +id: GO:0010163 +name: high-affinity potassium ion import +namespace: biological_process +def: "The directed, energized, high affinity movement of potassium ions into a cell or organelle, driven by cation symport with hydrogen or sodium ions." [PMID:8893537] +synonym: "high affinity potassium ion import" EXACT [] +synonym: "high affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb] +synonym: "high-affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006813 ! potassium ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0010164 +name: response to cesium +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010165 +name: response to X-ray +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, http://en.wikipedia.org/wiki/X-ray] +synonym: "response to X-ray radiation stimulus" EXACT [] +is_a: GO:0010212 ! response to ionizing radiation + +[Term] +id: GO:0010166 +name: wax metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm] +subset: gosubset_prok +synonym: "wax metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0010167 +name: response to nitrate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010168 +name: ER body +namespace: cellular_component +def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] +synonym: "endoplasmic reticulum body" EXACT [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0010169 +name: myrosinase complex +namespace: cellular_component +def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] +synonym: "thioglucosidase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0010170 +name: glucose-1-phosphate adenylyltransferase complex +namespace: cellular_component +def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0010171 +name: body morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0010172 +name: embryonic body morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the embryonic soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems] +is_a: GO:0010171 ! body morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0010174 +name: nucleoside transmembrane transporter activity, against a concentration gradient +namespace: molecular_function +def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] +synonym: "concentrative nucleoside transporter" EXACT [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0010175 +name: sphingosine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of amino alcohol sphingosine from one side of the membrane to the other." [GOC:tb] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0010176 +name: homogentisate phytyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + phytyl diphosphate -> 2-methyl-6-phytylplastoquinol." [PMID:14512521] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010177 +name: methylthioalkylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: w-methylthio-2-oxoalkanoic acid + acetyl-CoA + H2O = 2-(w-methylthio)alkylmalate + CoA." [GOC:pz] +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0010178 +name: IAA-amino acid conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0010179 +name: IAA-Ala conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: IAA-alanine -> indole-3-acetic acid + alanine." [GOC:tb] +is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity + +[Term] +id: GO:0010180 +name: thioglucosidase binding +namespace: molecular_function +def: "Interacting selectively with the enzyme thioglucosidase." [GOC:tb] +synonym: "myrosinase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0010181 +name: FMN binding +namespace: molecular_function +def: "Interacting selectively with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] +subset: gosubset_prok +synonym: "flavin mononucleotide binding" EXACT [] +is_a: GO:0000166 ! nucleotide binding +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0010182 +name: sugar mediated signaling +namespace: biological_process +def: "The process by which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361] +synonym: "sugar mediated signalling" EXACT [] +is_a: GO:0009756 ! carbohydrate mediated signaling + +[Term] +id: GO:0010183 +name: pollen tube guidance +namespace: biological_process +def: "The process by which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0048868 ! pollen tube development + +[Term] +id: GO:0010184 +name: cytokinin transport +namespace: biological_process +def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of, within or between cells." [GOC:lr] +is_a: GO:0006863 ! purine transport + +[Term] +id: GO:0010185 +name: regulation of cellular defense response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] +synonym: "regulation of cellular defence response" EXACT [] +is_a: GO:0031347 ! regulation of defense response +relationship: regulates GO:0006968 ! cellular defense response + +[Term] +id: GO:0010186 +name: positive regulation of cellular defense response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] +synonym: "activation of cellular defense response" NARROW [] +synonym: "positive regulation of cellular defence response" EXACT [] +synonym: "stimulation of cellular defense response" NARROW [] +synonym: "up regulation of cellular defense response" EXACT [] +synonym: "up-regulation of cellular defense response" EXACT [] +synonym: "upregulation of cellular defense response" EXACT [] +is_a: GO:0010185 ! regulation of cellular defense response +is_a: GO:0031349 ! positive regulation of defense response +relationship: positively_regulates GO:0006968 ! cellular defense response + +[Term] +id: GO:0010187 +name: negative regulation of seed germination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed germination." [GOC:tb] +synonym: "down regulation of seed germination" EXACT [] +synonym: "down-regulation of seed germination" EXACT [] +synonym: "downregulation of seed germination" EXACT [] +synonym: "inhibition of seed germination" NARROW [] +is_a: GO:0010029 ! regulation of seed germination +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0009845 ! seed germination + +[Term] +id: GO:0010188 +name: response to microbial phytotoxin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm] +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0010189 +name: vitamin E biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg] +subset: gosubset_prok +synonym: "alpha-tocopherol biosynthesis" NARROW [] +synonym: "alpha-tocopherol biosynthetic process" NARROW [] +synonym: "tocopherol biosynthesis" EXACT [] +synonym: "tocopherol biosynthetic process" EXACT [] +synonym: "vitamin E anabolism" EXACT [] +synonym: "vitamin E biosynthesis" EXACT [] +synonym: "vitamin E formation" EXACT [] +synonym: "vitamin E synthesis" EXACT [] +xref: MetaCyc:PWY-1422 +is_a: GO:0042360 ! vitamin E metabolic process +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process + +[Term] +id: GO:0010190 +name: cytochrome b6f complex assembly +namespace: biological_process +def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb] +subset: gosubset_prok +synonym: "cytochrome b6f complex biogenesis" EXACT [] +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0010191 +name: mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm] +subset: goslim_pir +synonym: "mucilage metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0010192 +name: mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm] +synonym: "mucilage anabolism" EXACT [] +synonym: "mucilage biosynthesis" EXACT [] +synonym: "mucilage formation" EXACT [] +synonym: "mucilage synthesis" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0010193 +name: response to ozone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0010194 +name: microRNA metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] +comment: This term was made obsolete because it implies further processing of an end product rather than its production. +is_obsolete: true +replaced_by: GO:0035196 + +[Term] +id: GO:0010195 +name: microRNA biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] +comment: This term was made obsolete because it represents a process that is not known to occur. +synonym: "microRNA anabolism" EXACT [] +synonym: "microRNA biosynthesis" EXACT [] +synonym: "microRNA formation" EXACT [] +synonym: "microRNA synthesis" EXACT [] +synonym: "miRNA biosynthesis" EXACT [] +synonym: "miRNA biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0035196 + +[Term] +id: GO:0010196 +name: nonphotochemical quenching +namespace: biological_process +def: "The process to maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0010197 +name: polar nucleus fusion +namespace: biological_process +def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm] +is_a: GO:0000741 ! karyogamy +relationship: part_of GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0010198 +name: synergid death +namespace: biological_process +alt_id: GO:0048470 +def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516] +synonym: "synergid cell death" EXACT [] +synonym: "synergid degeneration" EXACT [] +is_a: GO:0010623 ! developmental programmed cell death +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0010199 +name: organ boundary specification between lateral organs and the meristem +namespace: biological_process +def: "The process by which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116] +synonym: "organ boundary specification" BROAD [] +is_a: GO:0010160 ! formation of organ boundary + +[Term] +id: GO:0010200 +name: response to chitin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0010201 +name: response to continuous far red light stimulus by the high-irradiance response system +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm] +is_a: GO:0010218 ! response to far red light + +[Term] +id: GO:0010202 +name: response to low fluence red light stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] +is_a: GO:0009645 ! response to low light intensity stimulus +is_a: GO:0010114 ! response to red light + +[Term] +id: GO:0010203 +name: response to very low fluence red light stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] +is_a: GO:0010114 ! response to red light +is_a: GO:0055122 ! response to very low light intensity stimulus + +[Term] +id: GO:0010204 +name: defense response signaling pathway, resistance gene-independent +namespace: biological_process +def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm] +synonym: "defence response signaling pathway, resistance gene-independent" EXACT [] +synonym: "defence response signalling pathway, resistance gene-independent" EXACT [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0010205 +name: photoinhibition +namespace: biological_process +def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126] +synonym: "photosystem II inhibition" BROAD [] +is_a: GO:0009644 ! response to high light intensity +is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction +relationship: part_of GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0010206 +name: photosystem II repair +namespace: biological_process +def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the Photosystem II following photoinhibition." [GOC:sm] +is_a: GO:0044267 ! cellular protein metabolic process +relationship: part_of GO:0009765 ! photosynthesis, light harvesting + +[Term] +id: GO:0010207 +name: photosystem II assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on thylakoid membrane. In plants, the photosystem II complex consists of over 20 polypeptides encoded by either nuclear or chloroplast genome." [GOC:pz] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0010208 +name: pollen wall formation +namespace: biological_process +def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117] +is_a: GO:0045229 ! external encapsulating structure organization +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0010209 +name: vacuolar sorting signal binding +namespace: molecular_function +def: "Interacting selectively with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0010210 +name: IAA-Phe conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: IAA-phenylalanine -> indole-3-acetic acid + phenylalanine." [GOC:syr] +is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity + +[Term] +id: GO:0010211 +name: IAA-Leu conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: IAA-leucine -> indole-3-acetic acid + leucine." [GOC:syr] +is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity + +[Term] +id: GO:0010212 +name: response to ionizing radiation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] +synonym: "response to ionising radiation" EXACT [] +synonym: "response to ionizing radiation stimulus" EXACT [] +is_a: GO:0009314 ! response to radiation + +[Term] +id: GO:0010213 +name: non-photoreactive DNA repair +namespace: biological_process +def: "Process involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr] +subset: gosubset_prok +synonym: "light-independent DNA repair" EXACT [GOC:syr] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0010214 +name: seed coat development +namespace: biological_process +def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0010215 +name: cellulose microfibril organization +namespace: biological_process +def: "Oriented deposition of cellulose microfibrils during plant cell wall biosynthesis." [PMID:12468730] +synonym: "cellulose microfibril organisation" EXACT [] +is_a: GO:0009664 ! plant-type cell wall organization +relationship: part_of GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0010216 +name: maintenance of DNA methylation +namespace: biological_process +def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006306 ! DNA methylation + +[Term] +id: GO:0010217 +name: cellular aluminum ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of aluminum ions within a cell or between a cell and its external environment." [GOC:lr] +synonym: "aluminium ion homeostasis" BROAD [] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0055079 ! aluminum ion homeostasis + +[Term] +id: GO:0010218 +name: response to far red light +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] +synonym: "response to far red light stimulus" EXACT [] +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0010219 +name: regulation of vernalization response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0010048 ! vernalization response + +[Term] +id: GO:0010220 +name: positive regulation of vernalization response +namespace: biological_process +def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] +synonym: "activation of vernalization response" NARROW [] +synonym: "stimulation of vernalization response" NARROW [] +synonym: "up regulation of vernalization response" EXACT [] +synonym: "up-regulation of vernalization response" EXACT [] +synonym: "upregulation of vernalization response" EXACT [] +is_a: GO:0010219 ! regulation of vernalization response +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0010048 ! vernalization response + +[Term] +id: GO:0010221 +name: negative regulation of vernalization response +namespace: biological_process +def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] +synonym: "down regulation of vernalization response" EXACT [] +synonym: "down-regulation of vernalization response" EXACT [] +synonym: "downregulation of vernalization response" EXACT [] +synonym: "inhibition of vernalization response" NARROW [] +is_a: GO:0010219 ! regulation of vernalization response +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0010048 ! vernalization response + +[Term] +id: GO:0010222 +name: stem vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0010223 +name: secondary shoot formation +namespace: biological_process +def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068] +synonym: "auxiliary shoot formation" EXACT [] +synonym: "axillary shoot formation" EXACT [] +is_a: GO:0010346 ! shoot formation + +[Term] +id: GO:0010224 +name: response to UV-B +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm." [GOC:tb] +synonym: "response to medium wave ultraviolet light stimulus" EXACT [] +synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] +synonym: "response to UV-B light stimulus" EXACT [] +synonym: "response to UV-B radiation stimulus" EXACT [] +synonym: "response to UVB light stimulus" EXACT [] +synonym: "response to UVB radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0010225 +name: response to UV-C +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm." [GOC:tb] +synonym: "response to germicidal ultraviolet light stimulus" EXACT [] +synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] +synonym: "response to shortwave ultraviolet light stimulus" EXACT [] +synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] +synonym: "response to UV-C light stimulus" EXACT [] +synonym: "response to UV-C radiation stimulus" EXACT [] +synonym: "response to UVC light stimulus" EXACT [] +synonym: "response to UVC radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0010226 +name: response to lithium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010227 +name: floral organ abscission +namespace: biological_process +def: "The controlled shedding of floral organs." [PMID:12972671] +is_a: GO:0009838 ! abscission +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0010228 +name: vegetative to reproductive phase transition +namespace: biological_process +def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb] +synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135] +synonym: "flowering" RELATED [] +synonym: "transition from vegetative to reproductive phase" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009791 ! post-embryonic development +relationship: part_of GO:0048608 ! reproductive structure development + +[Term] +id: GO:0010229 +name: inflorescence development +namespace: biological_process +def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0010230 +name: alternative respiration +namespace: biological_process +def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399] +is_a: GO:0045333 ! cellular respiration + +[Term] +id: GO:0010231 +name: maintenance of seed dormancy +namespace: biological_process +def: "Any process by which a dormant state is maintained in a seed." [PMID:9580097] +is_a: GO:0009737 ! response to abscisic acid stimulus +is_a: GO:0022611 ! dormancy process +relationship: part_of GO:0010162 ! seed dormancy + +[Term] +id: GO:0010232 +name: vascular transport +namespace: biological_process +def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] +is_a: GO:0006810 ! transport +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0010233 +name: phloem transport +namespace: biological_process +def: "The directed movement of substances, into, out of or within a cell, either in a phloem tissue or in the phloem membrane." [GOC:sm] +is_a: GO:0010232 ! vascular transport + +[Term] +id: GO:0010234 +name: tapetal cell fate specification +namespace: biological_process +def: "The process by which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048657 ! tapetal cell differentiation + +[Term] +id: GO:0010235 +name: guard mother cell cytokinesis +namespace: biological_process +def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] +synonym: "guard mother cell division" EXACT [] +is_a: GO:0000911 ! cytokinesis by cell plate formation +relationship: part_of GO:0010440 ! stomatal lineage progression + +[Term] +id: GO:0010236 +name: plastoquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm] +synonym: "plastoquinone anabolism" EXACT [] +synonym: "plastoquinone biosynthesis" EXACT [] +synonym: "plastoquinone formation" EXACT [] +synonym: "plastoquinone synthesis" EXACT [] +xref: MetaCyc:PWY-1581 +is_a: GO:0045426 ! quinone cofactor biosynthetic process + +[Term] +id: GO:0010238 +name: response to proline +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm] +is_a: GO:0043200 ! response to amino acid stimulus + +[Term] +id: GO:0010239 +name: chloroplast mRNA processing +namespace: biological_process +def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738] +is_a: GO:0006397 ! mRNA processing +is_a: GO:0031425 ! chloroplast RNA processing + +[Term] +id: GO:0010240 +name: plastid pyruvate dehydrogenase complex +namespace: cellular_component +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] +synonym: "dehydrogenase complex (sensu Viridiplantae)" EXACT [] +is_a: GO:0044435 ! plastid part +is_a: GO:0045254 ! pyruvate dehydrogenase complex + +[Term] +id: GO:0010241 +name: ent-kaurene oxidase activity +namespace: molecular_function +def: "Catalysis of three successive oxidations of the 4-methyl group of ent-kaurene resulting in kaurenoic acid." [GOC:tb] +synonym: "ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [] +xref: EC:1.14.13.78 +xref: MetaCyc:1.14.13.78-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0010242 +name: oxygen evolving activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] +synonym: "photosynthetic water oxidation" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0010243 +name: response to organic nitrogen +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. Organic nitrogen is contained as amines in organic compounds such as amino acids and proteins." [PMID:9869419] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0010244 +name: response to low fluence blue light stimulus by blue low-fluence system +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709] +synonym: "response to low fluence blue light" BROAD [] +synonym: "response to low fluence blue light by blf system" EXACT [] +is_a: GO:0009637 ! response to blue light +is_a: GO:0009645 ! response to low light intensity stimulus + +[Term] +id: GO:0010245 +name: radial microtubular system formation +namespace: biological_process +def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0010246 +name: rhamnogalacturonan I biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz] +synonym: "rhamnogalacturonan I anabolism" EXACT [] +synonym: "rhamnogalacturonan I biosynthesis" EXACT [] +synonym: "rhamnogalacturonan I formation" EXACT [] +synonym: "rhamnogalacturonan I synthesis" EXACT [] +is_a: GO:0045489 ! pectin biosynthetic process + +[Term] +id: GO:0010247 +name: detection of phosphate ion +namespace: biological_process +def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "phosphate ion detection" EXACT [] +synonym: "phosphate ion perception" RELATED [] +synonym: "phosphate ion sensing" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0010248 +name: establishment or maintenance of transmembrane electrochemical gradient +namespace: biological_process +def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane." [GOC:mah, GOC:sm] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0010249 +name: auxin conjugate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm] +synonym: "auxin conjugate metabolism" EXACT [] +is_a: GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0010250 +name: S-methylmethionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340] +synonym: "S-methylmethionine anabolism" EXACT [] +synonym: "S-methylmethionine biosynthesis" EXACT [] +synonym: "S-methylmethionine formation" EXACT [] +synonym: "S-methylmethionine synthesis" EXACT [] +is_a: GO:0033477 ! S-methylmethionine metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0010252 +name: auxin homeostasis +namespace: biological_process +def: "Maintenance of endogenous concentration of primary auxin equilibrium, or constant level of auxin in a biological system by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/] +is_a: GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0010253 +name: UDP-rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748] +synonym: "UDP-rhamnose anabolism" EXACT [] +synonym: "UDP-rhamnose biosynthesis" EXACT [] +synonym: "UDP-rhamnose formation" EXACT [] +synonym: "UDP-rhamnose synthesis" EXACT [] +xref: MetaCyc:PWY-3261 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019300 ! rhamnose biosynthetic process +is_a: GO:0033478 ! UDP-rhamnose metabolic process + +[Term] +id: GO:0010254 +name: nectary development +namespace: biological_process +def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0010255 +name: glucose mediated signaling +namespace: biological_process +def: "The process by which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm] +synonym: "glucose mediated signalling" EXACT [] +is_a: GO:0009757 ! hexose mediated signaling + +[Term] +id: GO:0010256 +name: endomembrane organization +namespace: biological_process +def: "The assembly and arrangement of endomembrane systems." [GOC:sm] +synonym: "endomembrane system organization" EXACT [] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0010257 +name: NADH dehydrogenase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0010258 +name: NADH dehydrogenase complex (plastoquinone) assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332] +is_a: GO:0010257 ! NADH dehydrogenase complex assembly + +[Term] +id: GO:0010259 +name: multicellular organismal aging +namespace: biological_process +def: "The inherent decline of a multicellular organism over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu, GOC:sm] +is_a: GO:0007568 ! aging +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0010260 +name: organ senescence +namespace: biological_process +alt_id: GO:0010261 +def: "The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:mtg_sensu, GOC:sm] +synonym: "organ senescence (sensu Magnoliophyta)" EXACT [] +is_a: GO:0010149 ! senescence +relationship: part_of GO:0048856 ! anatomical structure development + +[Term] +id: GO:0010262 +name: somatic embryogenesis +namespace: biological_process +def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173] +is_a: GO:0009793 ! embryonic development ending in seed dormancy + +[Term] +id: GO:0010263 +name: tricyclic triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct] +synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators] +synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] +synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators] +synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators] +is_a: GO:0010683 ! tricyclic triterpenoid metabolic process +is_a: GO:0016104 ! triterpenoid biosynthetic process + +[Term] +id: GO:0010264 +name: myo-inositol hexakisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [ChEBI:17401, PMID:16107538] +synonym: "myo-inositol hexakisphosphate anabolism" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT [] +synonym: "myo-inositol hexakisphosphate formation" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis" EXACT [] +synonym: "phytate biosynthesis" EXACT [] +synonym: "phytate biosynthetic process" EXACT [] +is_a: GO:0032958 ! inositol phosphate biosynthetic process +is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process + +[Term] +id: GO:0010265 +name: SCF complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0010266 +name: response to vitamin B1 +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] +synonym: "response to thiamin" EXACT [] +synonym: "response to thiamine" EXACT [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0010267 +name: RNA interference, production of ta-siRNAs +namespace: biological_process +def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836] +is_a: GO:0030422 ! RNA interference, production of siRNA + +[Term] +id: GO:0010268 +name: brassinosteroid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of brassinosteroids within an organism or cell." [PMID:15908602] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0010269 +name: response to selenium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010270 +name: photosystem II oxygen evolving complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on thylakoid membrane. In plants, the photosystem II OEC consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ; and protects the CaMn4 cluster bound to D1 and CP43 proteins." [PMID:16282331] +synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331] +is_a: GO:0010207 ! photosystem II assembly + +[Term] +id: GO:0010271 +name: regulation of chlorophyll catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0051193 ! regulation of cofactor metabolic process +relationship: regulates GO:0015996 ! chlorophyll catabolic process + +[Term] +id: GO:0010272 +name: response to silver ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010273 +name: detoxification of copper ion +namespace: biological_process +def: "Any process that reduce or remove the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [PMID:16367966] +is_a: GO:0009636 ! response to toxin +is_a: GO:0046688 ! response to copper ion + +[Term] +id: GO:0010274 +name: hydrotropism +namespace: biological_process +def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172] +is_a: GO:0009606 ! tropism + +[Term] +id: GO:0010275 +name: NAD(P)H dehydrogenase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0010276 +name: phytol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytol + CTP = phytylphosphate + CDP." [PMID:16361393] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0010277 +name: chlorophyllide a oxygenase activity +namespace: molecular_function +alt_id: GO:0046407 +def: "Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] +synonym: "CAO" RELATED [EC:1.13.12.14] +synonym: "chlorophyll a oxygenase activity" EXACT [] +synonym: "chlorophyll b synthetase activity" EXACT [] +synonym: "chlorophyll-b synthase activity" EXACT [EC:1.13.12.14] +synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] +synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] +xref: EC:1.13.12.14 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0010278 +name: chloroplast outer membrane translocon +namespace: cellular_component +def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0010279 +name: indole-3-acetic acid amido synthetase +namespace: molecular_function +def: "Catalysis of the reaction IAA + an amino acid = an IAA amide conjugate." [PMID:15659623] +synonym: "IAA amido synthetase activity" EXACT [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0010280 +name: UDP-L-rhamnose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction UDP-D-glucose + NADPH = UDP-L-rhamnose + NADP+ + H2O." [GOC:tair_curators, PMID:14701918] +synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0010282 +name: senescence associated vacuole +namespace: cellular_component +def: "Vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] +is_a: GO:0000323 ! lytic vacuole + +[Term] +id: GO:0010283 +name: pinoresinol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinoresinol + NADPH = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010284 +name: lariciresinol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: lariciresinol + NADPH = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010285 +name: L,L-diaminopimelate aminotransferase activity +namespace: molecular_function +alt_id: GO:0043742 +def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O." [PMID:16361515] +synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] +synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83] +synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83] +synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] +synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83] +xref: EC:2.6.1.83 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0010286 +name: heat acclimation +namespace: biological_process +def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators] +is_a: GO:0009408 ! response to heat + +[Term] +id: GO:0010287 +name: plastoglobule +namespace: cellular_component +def: "Plastoglobules (PG) are lipoprotein particles present in chloroplasts. They are rich in non-polar lipids (triacylglycerols, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379] +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0010288 +name: response to lead ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010289 +name: homogalacturonan biosynthetic process +namespace: biological_process +def: "The formation from simpler components of the pectidic homogalacturonan, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543] +xref: MetaCyc:PWY-1061 +is_a: GO:0045489 ! pectin biosynthetic process + +[Term] +id: GO:0010290 +name: chlorophyll catabolite transporter activity +namespace: molecular_function +def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), into, out of, within or between cells." [PMID:9681016] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0010291 +name: carotene beta-ring hydroxylase activity +namespace: molecular_function +def: "Catalysis of C3-hydroxylation reaction of the beta-ring of various carotenes." [PMID:16492736] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0010292 +name: GTP:GDP antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0010293 +name: abscisic aldehyde oxidase activity +namespace: molecular_function +alt_id: GO:0033725 +def: "Catalysis of the reaction: abscisic aldehyde + H2O + O2 = abscisate + H2O2." [EC:1.2.3.14, PMID:11050171] +synonym: "AAO3" RELATED [EC:1.2.3.14] +synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14] +synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14] +synonym: "AOdelta" RELATED [EC:1.2.3.14] +xref: EC:1.2.3.14 +is_a: GO:0018488 ! aryl-aldehyde oxidase activity + +[Term] +id: GO:0010294 +name: abscisic acid glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ABA + UDP-D-glucose = ABA-glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] +xref: MetaCyc:PWY-5272 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0010295 +name: (+)-abscisic acid 8'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-abscisate + NADPH + H+ + O2 = 8'-hydroxyabscisate + NADP+ + H2O." [EC:1.14.13.93] +synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] +synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] +synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] +synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93] +synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] +xref: EC:1.14.13.93 +xref: MetaCyc:1.14.13.93-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0010296 +name: prenylcysteine methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein prenyl L-cysteine methylester + H2O = protein L-cysteine + methanol." [PMID:16870359] +is_a: GO:0051723 ! protein methylesterase activity + +[Term] +id: GO:0010297 +name: heteroglycan binding +namespace: molecular_function +def: "Interacting selectively with heteroglycans." [PMID:16640603] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0010298 +name: dihydrocamalexic acid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2." [PMID:16766671] +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0010299 +name: detoxification of cobalt ion +namespace: biological_process +def: "Any process that reduce or remove the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators] +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0010301 +name: xanthoxin dehydrogenase activity +namespace: molecular_function +alt_id: GO:0033710 +def: "Catalysis of the reaction: xanthoxin + NAD+ = abscisic aldehyde + NADH + H+." [EC:1.1.1.288, PMID:12172025] +synonym: "ABA2" RELATED [EC:1.1.1.288] +synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288] +synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288] +xref: EC:1.1.1.288 +is_a: GO:0004022 ! alcohol dehydrogenase activity + +[Term] +id: GO:0010302 +name: 2-oxoglutarate-dependent dioxygenase activity +namespace: molecular_function +def: "Hydroxylase, with 2-oxoglutarate as one donor, and incorporation or reduction of one atom each of oxygen into both donors." [EC:1.14.11.-, PMID:16140259] +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0010303 +name: limit dextrinase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (16)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] +synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142] +synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142] +synonym: "R-enzyme" RELATED [EC:3.2.1.142] +xref: EC:3.2.1.142 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0010304 +name: PSII associated light-harvesting complex II catabolic process +namespace: biological_process +def: "Catabolism of one or more components of the light-harvesting complex of photosystem II." [PMID:16157880] +synonym: "LHCII catabolism" RELATED [] +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0010305 +name: leaf vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0010306 +name: rhamnogalacturonan II biosynthetic process +namespace: biological_process +def: "The formation from simpler components of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267] +is_a: GO:0045489 ! pectin biosynthetic process + +[Term] +id: GO:0010307 +name: acetylglutamate kinase regulator activity +namespace: molecular_function +def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0010308 +name: acireductone dioxygenase (Ni2+-requiring) activity +namespace: molecular_function +def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO." [EC:1.13.11.53, PMID:16297065] +synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53] +synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] +synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] +synonym: "ARD activity" RELATED [EC:1.13.11.53] +synonym: "E-2 activity" RELATED [EC:1.13.11.53] +xref: EC:1.13.11.53 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0010309 +name: acireductone dioxygenase [iron(II)-requiring] activity +namespace: molecular_function +def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate." [EC:1.13.11.54, PMID:16297065] +subset: gosubset_prok +synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] +synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54] +synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] +synonym: "aci-reductone dioxygenase" BROAD [] +synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] +synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] +synonym: "ARD'" RELATED [] +synonym: "ARD1" RELATED [] +synonym: "E-2'" RELATED [] +xref: EC:1.13.11.54 +xref: MetaCyc:R147-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0010310 +name: regulation of hydrogen peroxide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions involving hydrogen peroxide." [PMID:14765119] +synonym: "regulation of hydrogen peroxide metabolism" EXACT [] +is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process +relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process + +[Term] +id: GO:0010311 +name: lateral root formation +namespace: biological_process +def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0010102 ! lateral root morphogenesis + +[Term] +id: GO:0010312 +name: detoxification of zinc ion +namespace: biological_process +def: "Any process that reduce or remove the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators] +is_a: GO:0009636 ! response to toxin +is_a: GO:0010043 ! response to zinc ion + +[Term] +id: GO:0010313 +name: phytochrome binding +namespace: molecular_function +def: "Interacting selectively with phytochrome." [PMID:15486102] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0010314 +name: phosphatidylinositol-5-phosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol-5-phosphate, a phosphorylated derivative of phosphatidylinositol." [GOC:tair_curators] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0010315 +name: auxin efflux +namespace: biological_process +def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators] +synonym: "auxin export" EXACT [] +is_a: GO:0009914 ! hormone transport + +[Term] +id: GO:0010316 +name: pyrophosphate-dependent phosphofructokinase complex +namespace: cellular_component +def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] +subset: goslim_pir +synonym: "PFK complex" RELATED [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0010317 +name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex +namespace: cellular_component +def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] +synonym: "PFK complex, alpha-subunit" RELATED [] +is_a: GO:0043234 ! protein complex +relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex + +[Term] +id: GO:0010318 +name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex +namespace: cellular_component +def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] +synonym: "PFK complex, beta-subunit" RELATED [] +is_a: GO:0043234 ! protein complex +relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex + +[Term] +id: GO:0010319 +name: stromule +namespace: cellular_component +def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] +synonym: "Stroma-filled tubule" RELATED [] +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009526 ! plastid envelope + +[Term] +id: GO:0010320 +name: arginine/lysine endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] +comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases. +is_obsolete: true +replaced_by: GO:0004175 +replaced_by: GO:0004197 + +[Term] +id: GO:0010321 +name: regulation of vegetative phase change +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0010050 ! vegetative phase change + +[Term] +id: GO:0010322 +name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway + +[Term] +id: GO:0010323 +name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] +synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW [] +is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway + +[Term] +id: GO:0010324 +name: membrane invagination +namespace: biological_process +def: "The infolding of a membrane, resulting in formation of a vesicle." [GOC:tb] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0010325 +name: raffinose family oligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators] +synonym: "raffinose family oligosaccharide biosynthesis" EXACT [] +is_a: GO:0009312 ! oligosaccharide biosynthetic process + +[Term] +id: GO:0010326 +name: methionine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalyzes the reaction: methionine + a 2-oxo acid = 4-methylthio-2-oxobutyrate + an amino acid." [PMID:17056707] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0010327 +name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity +namespace: molecular_function +def: "Catalyzes the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] +synonym: "hexenol acetyltransferase" RELATED [] +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0010328 +name: auxin influx transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] +synonym: "auxin influx facilitator" RELATED [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0010329 +name: auxin efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] +synonym: "auxin efflux carrier" RELATED [] +synonym: "auxin efflux facilitator" RELATED [] +is_a: GO:0015562 ! efflux transmembrane transporter activity +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0010330 +name: cellulose synthase complex +namespace: cellular_component +def: "The multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238] +synonym: "cellulose synthase complex (sensu Viridiplantae)" EXACT [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0010331 +name: gibberellin binding +namespace: molecular_function +def: "Interacting selectively with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators] +synonym: "gibberellic acid receptor" RELATED [] +synonym: "gibberellin receptor" RELATED [] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0010332 +name: response to gamma radiation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, http://en.wikipedia.org/wiki/Gamma_ray] +synonym: "response to gamma ra" RELATED [] +synonym: "response to gamma-ray photon" RELATED [] +is_a: GO:0010212 ! response to ionizing radiation + +[Term] +id: GO:0010333 +name: terpene synthase activity +namespace: molecular_function +def: "Catalyzing the formation of cyclic terpenes through the cyclization of linear terpenes containing varying quantities of isoprene units (i.e. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP)." [EC:4.2.3., GOC:tair_curators] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0010334 +name: sesquiterpene synthase activity +namespace: molecular_function +def: "Catalyzing the formation of sesquiterpenes (terpene containing 15 carbons, i.e. three isoprene units) through the cyclization of trans,trans-farnesyl diphosphate (an allylic prenyl diphosphate intermediates of the terpene biosynthesis pathway)." [EC:4.2.3.-, GOC:tair_curators] +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0010335 +name: response to non-ionic osmotic stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0010336 +name: gibberellic acid homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal equilibrium of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763] +synonym: "gibberrellin homeostasis" RELATED [] +is_a: GO:0009685 ! gibberellin metabolic process +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0010337 +name: regulation of salicylic acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions involving salicylic acid." [PMID:14765119] +synonym: "regulation of salicylic acid metabolism" RELATED [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0009696 ! salicylic acid metabolic process + +[Term] +id: GO:0010338 +name: leaf formation +namespace: biological_process +def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] +is_a: GO:0048645 ! organ formation +relationship: part_of GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0010339 +name: external side of cell wall +namespace: cellular_component +def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0010340 +name: carboxyl-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0010341 +name: gibberellin carboxyl-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + GA = S-adenosyl-L-homocysteine + GA methyl ester." [PMID:17220201] +is_a: GO:0010340 ! carboxyl-O-methyltransferase activity + +[Term] +id: GO:0010342 +name: cellularization of endosperm +namespace: biological_process +def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698] +synonym: "endosperm cellularization" EXACT [] +is_a: GO:0007349 ! cellularization + +[Term] +id: GO:0010343 +name: singlet oxygen-mediated programmed cell death +namespace: biological_process +def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:17075038] +synonym: "light-dependent programmed cell death" BROAD [] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0010344 +name: seed oilbody biogenesis +namespace: biological_process +def: "The assembly and arrangement of the seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triacylglycerol surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [PMID:16877495] +synonym: "oleosome biogenesis" RELATED [] +synonym: "seed oil body organization" EXACT [] +synonym: "spherosome biogenesis" RELATED [] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0010345 +name: suberin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262] +xref: MetaCyc:PWY-1121 +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0009699 ! phenylpropanoid biosynthetic process + +[Term] +id: GO:0010346 +name: shoot formation +namespace: biological_process +def: "The process that gives rise to a shoot. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0010016 ! shoot morphogenesis + +[Term] +id: GO:0010347 +name: L-galactose-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0010348 +name: lithium:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] +is_a: GO:0005451 ! monovalent cation:proton antiporter activity + +[Term] +id: GO:0010349 +name: L-galactose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] +synonym: "L-galactose 1-dehydrogenase activity" RELATED [] +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010350 +name: cellular response to magnesium starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0010351 +name: lithium ion transport +namespace: biological_process +def: "The directed movement of lithium ion into, out of, within or between cells." [PMID:17270011] +synonym: "lithium transport" EXACT [] +is_a: GO:0015672 ! monovalent inorganic cation transport + +[Term] +id: GO:0010352 +name: lithium ion export +namespace: biological_process +def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011] +synonym: "lithium export" EXACT [] +synonym: "lithium ion efflux" RELATED [] +is_a: GO:0010351 ! lithium ion transport + +[Term] +id: GO:0010353 +name: response to trehalose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0010354 +name: homogentisate prenyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0010355 +name: homogentisate farnesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate -> 2-methyl-6-farnesylplastoquinol." [PMID:16989822] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010356 +name: homogentisate geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate -> 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010357 +name: homogentisate solanesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + solanesyl diphosphate -> 2-methyl-6-solanesylplastoquinol." [PMID:16989822] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010358 +name: leaf shaping +namespace: biological_process +def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475] +synonym: "leaf structural organization" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0010359 +name: regulation of anion channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842] +subset: gosubset_prok +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0010360 +name: negative regulation of anion channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] +is_a: GO:0010359 ! regulation of anion channel activity +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity + +[Term] +id: GO:0010361 +name: regulation of anion channel activity by blue light +namespace: biological_process +def: "Any process by which the blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842] +synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010359 ! regulation of anion channel activity + +[Term] +id: GO:0010362 +name: negative regulation of anion channel activity by blue light +namespace: biological_process +def: "Any process by which the blue light stops, prevents or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] +synonym: "inhibition by blue light of anion channel activity" NARROW [] +synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010360 ! negative regulation of anion channel activity +is_a: GO:0010361 ! regulation of anion channel activity by blue light + +[Term] +id: GO:0010363 +name: regulation of plant-type hypersensitive response +namespace: biological_process +def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] +comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. +synonym: "regulation of HR" EXACT [] +synonym: "regulation of HR-PCD" EXACT [] +synonym: "regulation of plant hypersensitive response" EXACT [] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0009626 ! plant-type hypersensitive response + +[Term] +id: GO:0010364 +name: regulation of ethylene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +relationship: regulates GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0010365 +name: positive regulation of ethylene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0010364 ! regulation of ethylene biosynthetic process +is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0010366 +name: negative regulation of ethylene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0010364 ! regulation of ethylene biosynthetic process +is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0010367 +name: extracellular isoamylase complex +namespace: cellular_component +def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] +subset: gosubset_prok +is_a: GO:0043033 ! isoamylase complex +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0010368 +name: chloroplast isoamylase complex +namespace: cellular_component +def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators] +subset: gosubset_prok +is_a: GO:0043033 ! isoamylase complex +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0010369 +name: chromocenter +namespace: cellular_component +def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0010370 +name: perinucleolar chromocenter +namespace: cellular_component +def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] +is_a: GO:0010369 ! chromocenter + +[Term] +id: GO:0010371 +name: regulation of gibberellin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] +synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0009686 ! gibberellin biosynthetic process + +[Term] +id: GO:0010372 +name: positive regulation of gibberellin biosynthetic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] +synonym: "positive regulation of gibberellic acid biosynthetic process " NARROW [] +is_a: GO:0010371 ! regulation of gibberellin biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process + +[Term] +id: GO:0010373 +name: negative regulation of gibberellin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] +synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] +is_a: GO:0010371 ! regulation of gibberellin biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process + +[Term] +id: GO:0010374 +name: stomatal complex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0010375 +name: stomatal complex patterning +namespace: biological_process +def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0010376 +name: stomatal complex formation +namespace: biological_process +def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0010103 ! stomatal complex morphogenesis + +[Term] +id: GO:0010377 +name: guard cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259] +synonym: "stomatal cell fate commitment" RELATED [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0010052 ! guard cell differentiation + +[Term] +id: GO:0010378 +name: temperature compensation of the circadian clock +namespace: biological_process +def: "The process by which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] +subset: gosubset_prok +is_a: GO:0009266 ! response to temperature stimulus +relationship: part_of GO:0007623 ! circadian rhythm + +[Term] +id: GO:0010379 +name: phaseic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271 "http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5271&detail-level=3"] +xref: MetaCyc:PWY-5271 +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0010380 +name: regulation of chlorophyll biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0051193 ! regulation of cofactor metabolic process +relationship: regulates GO:0015995 ! chlorophyll biosynthetic process + +[Term] +id: GO:0010381 +name: attachment of peroxisome to chloroplast +namespace: biological_process +def: "The process by which a peroxisome is transported to, and/or maintained in, a location adjacent to the chloroplast." [PMID:17215364] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0010382 +name: cell wall metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:tair_curators] +subset: gosubset_prok +synonym: "cell wall metabolism" EXACT [] +is_a: GO:0007047 ! cell wall organization +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0010383 +name: cell wall polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators] +subset: gosubset_prok +is_a: GO:0010382 ! cell wall metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0010384 +name: cell wall proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] +synonym: "cell wall proteoglycan metabolism" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0010382 ! cell wall metabolic process + +[Term] +id: GO:0010385 +name: double-stranded methylated DNA binding +namespace: molecular_function +def: "Interacting selectively with double-stranded methylated DNA. Cytosine methylation in DNA is an important mechanism for establishing stable heritable epigenetic marks." [PMID:17242155] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0010386 +name: lateral root primordium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral root primordium over time, which initiates the formation to the mature structure. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [PMID:17259263] +is_a: GO:0048527 ! lateral root development + +[Term] +id: GO:0010387 +name: signalosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a signalosome." [PMID:17307927] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0010388 +name: cullin deneddylation +namespace: biological_process +def: "The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [PMID:17307927] +is_a: GO:0000338 ! protein deneddylation + +[Term] +id: GO:0010389 +name: regulation of G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [PMID:17329565] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0010390 +name: histone monoubiquitination +namespace: biological_process +def: "The modification of histones by addition of a single ubiquitin moiety." [PMID:17329563] +is_a: GO:0006513 ! protein monoubiquitination +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0010391 +name: glucomannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] +synonym: "glucomannan metabolism" EXACT [] +is_a: GO:0006080 ! substituted mannan metabolic process + +[Term] +id: GO:0010392 +name: galactoglucomannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators] +synonym: "galactoglucomannan metabolism" RELATED [] +is_a: GO:0006080 ! substituted mannan metabolic process + +[Term] +id: GO:0010393 +name: galacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators] +synonym: "galacturonan metabolism" EXACT [] +is_a: GO:0052546 ! cell wall pectin metabolic process + +[Term] +id: GO:0010394 +name: homogalacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators] +synonym: "homogalacturonan metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010395 +name: rhamnogalacturonan I metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators] +synonym: "RGI metabolism" RELATED [] +synonym: "rhamnogalacturonan I metabolism" EXACT [] +is_a: GO:0052546 ! cell wall pectin metabolic process + +[Term] +id: GO:0010396 +name: rhamnogalacturonan II metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] +synonym: "rhamnogalacturonan II metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010397 +name: apiogalacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(l->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators] +synonym: "apiogalacturonan metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010398 +name: xylogalacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators] +synonym: "xylogalacturonan metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010399 +name: rhamnogalacturonan I backbone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators] +synonym: "rhamnogalacturonan I backbone metabolism" EXACT [] +is_a: GO:0010395 ! rhamnogalacturonan I metabolic process + +[Term] +id: GO:0010400 +name: rhamnogalacturonan I side chain metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators] +synonym: "rhamnogalacturonan I side chain metabolism" EXACT [] +is_a: GO:0010395 ! rhamnogalacturonan I metabolic process + +[Term] +id: GO:0010401 +name: pectic galactan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] +synonym: "pectic galactan metabolism" EXACT [] +is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process + +[Term] +id: GO:0010402 +name: pectic arabinan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabinan, a polymer with an alpha-(1->5)-linked -L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] +synonym: "pectic arabinan metabolism" EXACT [] +is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process +is_a: GO:0031221 ! arabinan metabolic process + +[Term] +id: GO:0010403 +name: pectic arabinogalactan I metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1->4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators] +synonym: "pectic arabinogalactan I metabolism" EXACT [] +is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process + +[Term] +id: GO:0010404 +name: cell wall hydroxyproline-rich glycoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] +synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process +is_a: GO:0010384 ! cell wall proteoglycan metabolic process + +[Term] +id: GO:0010405 +name: arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators] +synonym: "arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process + +[Term] +id: GO:0010406 +name: classical arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators] +synonym: "classical-arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010405 ! arabinogalactan protein metabolic process + +[Term] +id: GO:0010407 +name: non-classical arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators] +synonym: "non-classical arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010405 ! arabinogalactan protein metabolic process + +[Term] +id: GO:0010408 +name: fasciclin-like arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators] +synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010405 ! arabinogalactan protein metabolic process + +[Term] +id: GO:0010409 +name: extensin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators] +synonym: "extensin metabolism" EXACT [] +is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process + +[Term] +id: GO:0010410 +name: hemicellulose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators] +subset: gosubset_prok +synonym: "hemicellulose metabolism" EXACT [] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process + +[Term] +id: GO:0010411 +name: xyloglucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators] +synonym: "xyloglucan metabolism" EXACT [] +is_a: GO:0010410 ! hemicellulose metabolic process + +[Term] +id: GO:0010412 +name: mannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators] +subset: gosubset_prok +synonym: "mannan metabolism" EXACT [] +is_a: GO:0010410 ! hemicellulose metabolic process + +[Term] +id: GO:0010413 +name: glucuronoxylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators] +synonym: "glucuronoxylan metabolism" EXACT [] +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0010414 +name: glucuronoarabinoxylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators] +synonym: "glucuronoarabinoxylan metabolism" EXACT [] +is_a: GO:0010413 ! glucuronoxylan metabolic process +is_a: GO:0010416 ! arabinoxylan metabolic process + +[Term] +id: GO:0010415 +name: unsubstituted mannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators] +synonym: "unsubstituted mannan metabolism" EXACT [] +is_a: GO:0010412 ! mannan metabolic process + +[Term] +id: GO:0010416 +name: arabinoxylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators] +synonym: "arabinoxylan metabolism" EXACT [] +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0010417 +name: glucuronoxylan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators] +synonym: "glucuronoxylan anabolism" EXACT [] +synonym: "glucuronoxylan biosynthesis" EXACT [] +synonym: "glucuronoxylan formation" EXACT [] +synonym: "glucuronoxylan synthesis" EXACT [] +is_a: GO:0010413 ! glucuronoxylan metabolic process + +[Term] +id: GO:0010418 +name: rhamnogalacturonan II backbone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] +synonym: "rhamnogalacturonan II backbone metabolism" EXACT [] +is_a: GO:0010394 ! homogalacturonan metabolic process +is_a: GO:0010396 ! rhamnogalacturonan II metabolic process + +[Term] +id: GO:0010419 +name: rhamnogalacturonan II side chain metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators] +synonym: "rhamnogalacturonan II side chain metabolism" EXACT [] +is_a: GO:0010396 ! rhamnogalacturonan II metabolic process + +[Term] +id: GO:0010420 +name: polyprenyldihydroxybenzoate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate (or 3-polyprenyl-5-hydroxy-4-methoxybenzoate)." [PMID:9628017] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0010421 +name: hydrogen peroxide-mediated programmed cell death +namespace: biological_process +def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:16036580] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0010422 +name: regulation of brassinosteroid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process + +[Term] +id: GO:0010423 +name: negative regulation of brassinosteroid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] +is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process + +[Term] +id: GO:0010424 +name: DNA methylation on cytosine within a CG sequence +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600] +synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0010425 +name: DNA methylation on cytosine within a CNG sequence +namespace: biological_process +def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] +synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0010426 +name: DNA methylation on cytosine within a CNN sequence +namespace: biological_process +def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNN sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] +synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0010427 +name: abscisic acid binding +namespace: molecular_function +def: "Interacting selectively with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412] +synonym: "ABA binding" RELATED [] +synonym: "abscisate binding" RELATED [] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0010428 +name: methyl-CpNpG binding +namespace: molecular_function +def: "Interacting selectively with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0010429 +name: methyl-CpNpN binding +namespace: molecular_function +def: "Interacting selectively with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0010430 +name: fatty acid omega-oxidation +namespace: biological_process +def: "The metabolic oxidation of a long-chain fatty acid by successive cycles of reactions during each of which the omega-carbon in a fatty acid (the carbon furthest in the alkyl chain from the carboxylic acid) is progressively oxidized first to an alcohol and then to a carboxylic acid, creating a molecule with a carboxylic acid on both ends." [PMID:16404574] +xref: MetaCyc:PWY-2724 +is_a: GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0010431 +name: seed maturation +namespace: biological_process +def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0010432 +name: bract development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] +is_a: GO:0048827 ! phyllome development + +[Term] +id: GO:0010433 +name: bract morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. Morphogenesis pertains to the creation of form." [GOC:tb, PMID:16554366, PO:0009055] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0010432 ! bract development + +[Term] +id: GO:0010434 +name: bract formation +namespace: biological_process +def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0010433 ! bract morphogenesis + +[Term] +id: GO:0010435 +name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid (OPC-8:0) + CoA = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)- cyclopentane-1-octanoyl-CoA." [PMID:16963437] +synonym: "OPC-8:0 CoA ligase activity" RELATED [] +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0010436 +name: carotenoid dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] +synonym: "carotenoid-cleaving dioxygenase" RELATED [] +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0010437 +name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] +is_a: GO:0010436 ! carotenoid dioxygenase activity + +[Term] +id: GO:0010438 +name: cellular response to sulfur starvation +namespace: biological_process +def: "A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0010439 +name: regulation of glucosinolate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0019761 ! glucosinolate biosynthetic process + +[Term] +id: GO:0010440 +name: stomatal lineage progression +namespace: biological_process +def: "The process by which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0010374 ! stomatal complex development + +[Term] +id: GO:0010441 +name: guard cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0010052 ! guard cell differentiation + +[Term] +id: GO:0010442 +name: guard cell morphogenesis +namespace: biological_process +def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb] +synonym: "guard cell morphogenesis during differentiation" EXACT [] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0010441 ! guard cell development + +[Term] +id: GO:0010443 +name: meristemoid mother cell division +namespace: biological_process +def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] +synonym: "meristemoid division" RELATED [] +is_a: GO:0000911 ! cytokinesis by cell plate formation +relationship: part_of GO:0010440 ! stomatal lineage progression + +[Term] +id: GO:0010444 +name: guard mother cell differentiation +namespace: biological_process +def: "The process by which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0010440 ! stomatal lineage progression + +[Term] +id: GO:0010445 +name: nuclear dicing body +namespace: cellular_component +def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] +synonym: "D body" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0010446 +name: response to alkalinity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7." [GOC:tb] +synonym: "response to alkaline pH" EXACT [] +synonym: "response to basic pH" EXACT [] +is_a: GO:0009268 ! response to pH + +[Term] +id: GO:0010447 +name: response to acidity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7." [GOC:tb] +synonym: "response to acidic pH" EXACT [] +is_a: GO:0009268 ! response to pH + +[Term] +id: GO:0010448 +name: vegetative meristem growth +namespace: biological_process +def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928] +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0048367 ! shoot development + +[Term] +id: GO:0010449 +name: root meristem growth +namespace: biological_process +def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb] +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0010450 +name: inflorescence meristem growth +namespace: biological_process +def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb] +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0010229 ! inflorescence development + +[Term] +id: GO:0010451 +name: floral meristem growth +namespace: biological_process +def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb] +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0010452 +name: histone H3-K36 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to lysine at position 36 of the histone." [GOC:tb] +synonym: "histone H3 K36 methylation" EXACT [GOC:tb] +synonym: "histone H3K36me" EXACT [GOC:tb] +synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0010453 +name: regulation of cell fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0045165 ! cell fate commitment + +[Term] +id: GO:0010454 +name: negative regulation of cell fate commitment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0045165 ! cell fate commitment + +[Term] +id: GO:0010455 +name: positive regulation of cell fate commitment +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0045165 ! cell fate commitment + +[Term] +id: GO:0010456 +name: cell proliferation in dorsal spinal cord +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0010457 +name: centriole-centriole cohesion +namespace: biological_process +def: "The process by which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] +is_a: GO:0051297 ! centrosome organization + +[Term] +id: GO:0010458 +name: exit from mitosis +namespace: biological_process +def: "The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000087 ! M phase of mitotic cell cycle + +[Term] +id: GO:0010459 +name: negative regulation of heart rate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0045822 ! negative regulation of heart contraction + +[Term] +id: GO:0010460 +name: positive regulation of heart rate +namespace: biological_process +def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0045823 ! positive regulation of heart contraction + +[Term] +id: GO:0010461 +name: light-activated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] +is_a: GO:0005216 ! ion channel activity + +[Term] +id: GO:0010462 +name: regulation of light-activated voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb] +is_a: GO:0016061 ! regulation of light-activated channel activity +is_a: GO:0050848 ! regulation of calcium-mediated signaling +is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel + +[Term] +id: GO:0010463 +name: mesenchymal cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0010464 +name: regulation of mesenchymal cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0010463 ! mesenchymal cell proliferation + +[Term] +id: GO:0010465 +name: nerve growth factor receptor activity +namespace: molecular_function +def: "Combining with nerve growth factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] +is_a: GO:0005030 ! neurotrophin receptor activity + +[Term] +id: GO:0010466 +name: negative regulation of peptidase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:0010467 +name: gene expression +namespace: biological_process +def: "The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0010468 +name: regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] +subset: gosubset_prok +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0010467 ! gene expression + +[Term] +id: GO:0010469 +name: regulation of receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0010470 +name: regulation of gastrulation +namespace: biological_process +def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0045995 ! regulation of embryonic development +relationship: regulates GO:0007369 ! gastrulation + +[Term] +id: GO:0010471 +name: GDP-galactose:mannose-1-phosphate guanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-galactose-1-phosphate + mannose-1-phosphate = galactose-1-phosphate + GDP-mannose." [PMID:17485667] +is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity + +[Term] +id: GO:0010472 +name: GDP-galactose:glucose-1-phosphate guanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-galactose-1-phosphate + glucose-1-phosphate = galactose-1-phosphate + GDP-glucose." [PMID:17485667] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0010473 +name: GDP-galactose:myoinositol-1-phosphate guanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-galactose-1-phosphate + myoinositol-1-phosphate = galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0010474 +name: glucose-1-phosphate guanylyltransferase (GDP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] +synonym: "GDP:Glucose-1- phosphate guanyltransferase activity " EXACT [] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0010475 +name: galactose-1-phosphate guanylyltransferase (GDP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0010476 +name: gibberellin-mediated signaling +namespace: biological_process +def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411] +is_a: GO:0009755 ! hormone-mediated signaling + +[Term] +id: GO:0010477 +name: response to sulfur dioxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010478 +name: chlororespiration +namespace: biological_process +def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537] +is_a: GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0010479 +name: stele development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0010480 +name: microsporocyte differentiation +namespace: biological_process +def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248 "Cell type ontology", PMID:16751349] +synonym: "pollen mother cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0010481 +name: epidermal cell division +namespace: biological_process +def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0010482 +name: regulation of epidermal cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0010481 ! epidermal cell division + +[Term] +id: GO:0010483 +name: pollen tube reception +namespace: biological_process +def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660] +is_a: GO:0051703 ! intraspecies interaction between organisms +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0010484 +name: H3 histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H3." [PMID:17877703] +is_a: GO:0004406 ! H3/H4 histone acetyltransferase activity + +[Term] +id: GO:0010485 +name: H4 histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H4." [PMID:17877703] +is_a: GO:0004406 ! H3/H4 histone acetyltransferase activity + +[Term] +id: GO:0010486 +name: manganese:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] +is_a: GO:0051139 ! metal ion:hydrogen antiporter activity + +[Term] +id: GO:0010487 +name: thermospermine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + thermospermine." [PMID:17560575] +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0010488 +name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0010489 +name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose -> UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0010490 +name: UDP-4-keto-rhamnose-4-keto-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH -> UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010491 +name: UTP:arabinose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0010492 +name: maintenance of shoot apical meristem identity +namespace: biological_process +def: "The process by which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010493 +name: Lewis a epitope biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-1->4(Gal-beta-1->3)GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273] +synonym: "LE A biosynthetic process" RELATED [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0010494 +name: stress granule +namespace: cellular_component +def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [PMID:17601829] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0010495 +name: long-distance posttranscriptional gene silencing +namespace: biological_process +def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412] +synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0010496 +name: intercellular transport +namespace: biological_process +def: "The movement of substances between cells in a multicellular organism." [GOC:dl] +is_a: GO:0006810 ! transport +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0010497 +name: plasmodesmata-mediated intercellular transport +namespace: biological_process +def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829] +synonym: "plasmodesma-mediated cell-to-cell transport" EXACT [] +synonym: "plasmodesma-mediated intercellular transport" EXACT [] +synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT [] +is_a: GO:0010496 ! intercellular transport + +[Term] +id: GO:0010498 +name: proteasomal protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] +synonym: "proteasome-mediated protein catabolic process" EXACT [] +synonym: "proteasome-mediated protein catabolism" EXACT [] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0010499 +name: proteasomal ubiquitin-independent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb] +is_a: GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:0010500 +name: transmitting tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426] +is_a: GO:0048467 ! gynoecium development + +[Term] +id: GO:0010501 +name: RNA secondary structure unwinding +namespace: biological_process +def: "The process by which a secondary structure of RNA are broken or 'melted'." [PMID:17169986] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0010502 +name: plastoglobuli +namespace: cellular_component +def: "Lipid bodies localized within the chloroplast stroma." [PMID:17259290] +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0010503 +name: negative regulation of cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] +is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation +is_a: GO:0010516 ! negative regulation of cellular response to nitrogen starvation +relationship: negatively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation + +[Term] +id: GO:0010504 +name: regulation of cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation + +[Term] +id: GO:0010505 +name: positive regulation of cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] +is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0032109 ! positive regulation of response to nutrient levels +relationship: positively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation + +[Term] +id: GO:0010506 +name: regulation of autophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0006914 ! autophagy + +[Term] +id: GO:0010507 +name: negative regulation of autophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0031330 ! negative regulation of cellular catabolic process +relationship: negatively_regulates GO:0006914 ! autophagy + +[Term] +id: GO:0010508 +name: positive regulation of autophagy +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0031331 ! positive regulation of cellular catabolic process +relationship: positively_regulates GO:0006914 ! autophagy + +[Term] +id: GO:0010509 +name: polyamine homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal equilibrium of a polyamine." [GOC:dph, GOC:rh, GOC:tb, PMID:11161802, PMID:9761731] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0010510 +name: regulation of acetyl-CoA biosynthetic process from pyruvate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate + +[Term] +id: GO:0010511 +name: regulation of phosphatidylinositol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0010512 +name: negative regulation of phosphatidylinositol biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0010513 +name: positive regulation of phosphatidylinositol biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0010514 +name: induction of conjugation with cellular fusion +namespace: biological_process +def: "The process by which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb] +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0010515 +name: negative regulation of induction of conjugation with cellular fusion +namespace: biological_process +def: "The process by which a cell decreases the rate or frequency of the initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion +relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion + +[Term] +id: GO:0010516 +name: negative regulation of cellular response to nitrogen starvation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032108 ! negative regulation of response to nutrient levels +relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation + +[Term] +id: GO:0010517 +name: regulation of phospholipase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0010518 +name: positive regulation of phospholipase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0010517 ! regulation of phospholipase activity +is_a: GO:0060193 ! positive regulation of lipase activity + +[Term] +id: GO:0010519 +name: negative regulation of phospholipase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0010517 ! regulation of phospholipase activity +is_a: GO:0060192 ! negative regulation of lipase activity + +[Term] +id: GO:0010520 +name: regulation of reciprocal meiotic recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of recombination during meiosis." [GOC:dph, GOC:tb] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0040020 ! regulation of meiosis +relationship: regulates GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010521 +name: telomerase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0010522 +name: regulation of calcium ion transport into cytosol +namespace: biological_process +def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] +is_a: GO:0051924 ! regulation of calcium ion transport + +[Term] +id: GO:0010523 +name: negative regulation of calcium ion transport into cytosol +namespace: biological_process +def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] +is_a: GO:0010522 ! regulation of calcium ion transport into cytosol +is_a: GO:0051926 ! negative regulation of calcium ion transport + +[Term] +id: GO:0010524 +name: positive regulation of calcium ion transport into cytosol +namespace: biological_process +def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] +is_a: GO:0010522 ! regulation of calcium ion transport into cytosol +is_a: GO:0051928 ! positive regulation of calcium ion transport + +[Term] +id: GO:0010525 +name: regulation of transposition, RNA-mediated +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] +is_a: GO:0010528 ! regulation of transposition +relationship: regulates GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0010526 +name: negative regulation of transposition, RNA-mediated +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] +is_a: GO:0010525 ! regulation of transposition, RNA-mediated +is_a: GO:0010529 ! negative regulation of transposition +relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0010527 +name: positive regulation of transposition, RNA-mediated +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] +is_a: GO:0010525 ! regulation of transposition, RNA-mediated +is_a: GO:0010530 ! positive regulation of transposition +relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0010528 +name: regulation of transposition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] +subset: gosubset_prok +is_a: GO:0000018 ! regulation of DNA recombination +relationship: regulates GO:0032196 ! transposition + +[Term] +id: GO:0010529 +name: negative regulation of transposition +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] +is_a: GO:0010528 ! regulation of transposition +is_a: GO:0045910 ! negative regulation of DNA recombination +relationship: negatively_regulates GO:0032196 ! transposition + +[Term] +id: GO:0010530 +name: positive regulation of transposition +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] +is_a: GO:0010528 ! regulation of transposition +is_a: GO:0045911 ! positive regulation of DNA recombination +relationship: positively_regulates GO:0032196 ! transposition + +[Term] +id: GO:0010531 +name: activation of JAK1 kinase activity +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "activation of JAK1 protein" EXACT [GOC:dph, GOC:tb] +synonym: "tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:0010532 +name: regulation of activation of JAK1 kinase activity +namespace: biological_process +def: "Any process that modulates the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010533 ! regulation of activation of Janus kinase activity +relationship: regulates GO:0010531 ! activation of JAK1 kinase activity + +[Term] +id: GO:0010533 +name: regulation of activation of Janus kinase activity +namespace: biological_process +def: "Any process that modulates the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582] +synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0046425 ! regulation of JAK-STAT cascade +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: regulates GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:0010534 +name: regulation of activation of JAK2 kinase activity +namespace: biological_process +def: "Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010533 ! regulation of activation of Janus kinase activity +relationship: regulates GO:0042977 ! activation of JAK2 kinase activity + +[Term] +id: GO:0010535 +name: positive regulation of activation of JAK2 kinase activity +namespace: biological_process +def: "Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "positive regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010534 ! regulation of activation of JAK2 kinase activity +is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity +relationship: positively_regulates GO:0042977 ! activation of JAK2 kinase activity + +[Term] +id: GO:0010536 +name: positive regulation of activation of Janus kinase activity +namespace: biological_process +def: "Any process that increases the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010533 ! regulation of activation of Janus kinase activity +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:0010537 +name: positive regulation of activation of JAK1 kinase activity +namespace: biological_process +def: "Any process that increases the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "positive regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010532 ! regulation of activation of JAK1 kinase activity +is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity +relationship: positively_regulates GO:0010531 ! activation of JAK1 kinase activity + +[Term] +id: GO:0010538 +name: Hsp27 protein regulator activity +namespace: molecular_function +def: "Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764] +is_a: GO:0030188 ! chaperone regulator activity + +[Term] +id: GO:0010539 +name: Hsp27 protein inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb] +is_a: GO:0010538 ! Hsp27 protein regulator activity +is_a: GO:0030190 ! chaperone inhibitor activity + +[Term] +id: GO:0010540 +name: basipetal auxin transport +namespace: biological_process +def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] +is_a: GO:0009926 ! auxin polar transport + +[Term] +id: GO:0010541 +name: acropetal auxin transport +namespace: biological_process +def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] +is_a: GO:0009926 ! auxin polar transport + +[Term] +id: GO:0010542 +name: nitrate efflux transmembrane transporter activity +namespace: molecular_function +is_a: GO:0015113 ! nitrite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0010543 +name: regulation of platelet activation +namespace: biological_process +def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:tb] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0030168 ! platelet activation + +[Term] +id: GO:0010544 +name: negative regulation of platelet activation +namespace: biological_process +def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:tb] +is_a: GO:0010543 ! regulation of platelet activation +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:0050866 ! negative regulation of cell activation +relationship: negatively_regulates GO:0030168 ! platelet activation + +[Term] +id: GO:0010545 +name: Hsp90 protein regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632] +is_a: GO:0030188 ! chaperone regulator activity +is_a: GO:0051879 ! Hsp90 protein binding + +[Term] +id: GO:0010546 +name: Hsp90 protein inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632] +is_a: GO:0010545 ! Hsp90 protein regulator activity +is_a: GO:0030190 ! chaperone inhibitor activity + +[Term] +id: GO:0010547 +name: thylakoid membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733] +synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010027 ! thylakoid membrane organization +is_a: GO:0030397 ! membrane disassembly + +[Term] +id: GO:0010548 +name: regulation of thylakoid membrane disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733] +synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010549 ! regulation of membrane disassembly +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0010547 ! thylakoid membrane disassembly + +[Term] +id: GO:0010549 +name: regulation of membrane disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0030397 ! membrane disassembly + +[Term] +id: GO:0010550 +name: regulation of PSII associated light-harvesting complex II catabolic process +namespace: biological_process +def: "Any process that modulates the catabolism of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb] +synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733] +synonym: "regulation of LHCII degradation" EXACT [PMID:17416733] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process + +[Term] +id: GO:0010551 +name: regulation of specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0032583 ! regulation of gene-specific transcription +relationship: regulates GO:0032569 ! specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0010552 +name: positive regulation of specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb] +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +is_a: GO:0043193 ! positive regulation of gene-specific transcription +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter +relationship: positively_regulates GO:0032569 ! specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0010553 +name: negative regulation of specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +is_a: GO:0032582 ! negative regulation of gene-specific transcription +relationship: negatively_regulates GO:0032569 ! specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0010554 +name: neurotransmitter secretory pathway +namespace: biological_process +def: "A regulated secretory pathway in which neurotransmitters are initially stored in secretory vesicles for later release." [GOC:dph, GOC:tb] +is_a: GO:0045055 ! regulated secretory pathway +relationship: part_of GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0010555 +name: response to mannitol stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [PMID:17999646] +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0010556 +name: regulation of macromolecule biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +subset: gosubset_prok +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010557 +name: positive regulation of macromolecule biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010558 +name: negative regulation of macromolecule biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010559 +name: regulation of glycoprotein biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] +subset: gosubset_prok +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0010560 +name: positive regulation of glycoprotein biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0010561 +name: negative regulation of glycoprotein biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0010562 +name: positive regulation of phosphorus metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: positively_regulates GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0010563 +name: negative regulation of phosphorus metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0010564 +name: regulation of cell cycle process +namespace: biological_process +def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] +is_a: GO:0051726 ! regulation of cell cycle +relationship: regulates GO:0022402 ! cell cycle process + +[Term] +id: GO:0010565 +name: regulation of ketone metabolic process +namespace: biological_process +def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0010566 +name: regulation of ketone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010565 ! regulation of ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0042181 ! ketone biosynthetic process + +[Term] +id: GO:0010567 +name: regulation of ketone catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010565 ! regulation of ketone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0042182 ! ketone catabolic process + +[Term] +id: GO:0010568 +name: regulation of budding cell apical growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630] +is_a: GO:0007116 ! regulation of cell budding +is_a: GO:0040008 ! regulation of growth +relationship: regulates GO:0007118 ! budding cell apical bud growth + +[Term] +id: GO:0010569 +name: regulation of double-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0010570 +name: regulation of filamentous growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0040008 ! regulation of growth +relationship: regulates GO:0030447 ! filamentous growth + +[Term] +id: GO:0010571 +name: positive regulation of DNA replication during S phase +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA replication during progression through S phase of the cell cycle." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0033262 ! regulation of DNA replication during S phase +is_a: GO:0045740 ! positive regulation of DNA replication +relationship: positively_regulates GO:0033260 ! DNA replication during S phase + +[Term] +id: GO:0010572 +name: positive regulation of platelet activation +namespace: biological_process +def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0010543 ! regulation of platelet activation +is_a: GO:0050867 ! positive regulation of cell activation +relationship: positively_regulates GO:0030168 ! platelet activation + +[Term] +id: GO:0010573 +name: vascular endothelial growth factor production +namespace: biological_process +def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0010574 +name: regulation of vascular endothelial growth factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0010573 ! vascular endothelial growth factor production + +[Term] +id: GO:0010575 +name: positive regulation vascular endothelial growth factor production +namespace: biological_process +def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0010574 ! regulation of vascular endothelial growth factor production +relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production + +[Term] +id: GO:0010576 +name: metalloenzyme regulator activity +namespace: molecular_function +def: "Modulates the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0010577 +name: metalloenzyme activator activity +namespace: molecular_function +def: "Increases the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0010576 ! metalloenzyme regulator activity + +[Term] +id: GO:0010578 +name: regulation of adenylate cyclase activity involved in G-protein signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] +is_a: GO:0045761 ! regulation of adenylate cyclase activity +relationship: part_of GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger + +[Term] +id: GO:0010579 +name: positive regulation of adenylate cyclase activity involved in G-protein signaling +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of adenylate cyclase activity that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] +is_a: GO:0010578 ! regulation of adenylate cyclase activity involved in G-protein signaling +is_a: GO:0045762 ! positive regulation of adenylate cyclase activity +relationship: part_of GO:0007189 ! G-protein signaling, adenylate cyclase activating pathway + +[Term] +id: GO:0010580 +name: activation of adenylate cyclase activity involved in G-protein signaling +namespace: biological_process +def: "Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] +is_a: GO:0007190 ! activation of adenylate cyclase activity +is_a: GO:0010579 ! positive regulation of adenylate cyclase activity involved in G-protein signaling + +[Term] +id: GO:0010581 +name: regulation of starch biosynthetic process +namespace: biological_process +def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +relationship: regulates GO:0019252 ! starch biosynthetic process + +[Term] +id: GO:0010582 +name: floral meristem determinacy +namespace: biological_process +def: "The process by which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215] +is_a: GO:0010022 ! meristem determinacy +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0010583 +name: response to cyclopentenone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0010584 +name: pollen exine formation +namespace: biological_process +def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dl] +is_a: GO:0010208 ! pollen wall formation + +[Term] +id: GO:0010585 +name: glutamine secretion +namespace: biological_process +def: "The regulated release of glutamine by a cell, a group of cells, or a tissue." [PMID:15208395] +is_a: GO:0006868 ! glutamine transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0010586 +name: miRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] +synonym: "microRNA metabolic process" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0010587 +name: miRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] +synonym: "microRNA catabolic process" EXACT [] +is_a: GO:0010586 ! miRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0010588 +name: cotyledon vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0010589 +name: leaf proximal/distal pattern formation +namespace: biological_process +def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054] +is_a: GO:0009954 ! proximal/distal pattern formation + +[Term] +id: GO:0010590 +name: regulation of cell separation during cytokinesis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:dph, GOC:tb] +is_a: GO:0032954 ! regulation of cytokinetic process +relationship: regulates GO:0000920 ! cell separation during cytokinesis + +[Term] +id: GO:0010591 +name: regulation of lamellipodium biogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0030032 ! lamellipodium biogenesis + +[Term] +id: GO:0010592 +name: positive regulation of lamellipodium biogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] +is_a: GO:0010591 ! regulation of lamellipodium biogenesis +is_a: GO:0031346 ! positive regulation of cell projection organization +relationship: positively_regulates GO:0030032 ! lamellipodium biogenesis + +[Term] +id: GO:0010593 +name: negative regulation of lamellipodium biogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] +is_a: GO:0010591 ! regulation of lamellipodium biogenesis +is_a: GO:0031345 ! negative regulation of cell projection organization +relationship: negatively_regulates GO:0030032 ! lamellipodium biogenesis + +[Term] +id: GO:0010594 +name: regulation of endothelial cell migration +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the orderly movement of endothelial cells into the extracellular matrix to form an endothelium." [GOC:dph, GOC:tb] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0010595 +name: positive regulation of endothelial cell migration +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the orderly movement of endothelial cells into the extracellular matrix to form an endothelium." [GOC:dph, GOC:tb] +is_a: GO:0010594 ! regulation of endothelial cell migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0010596 +name: negative regulation of endothelial cell migration +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the orderly movement of endothelial cells into the extracellular matrix to form an endothelium." [GOC:dph, GOC:tb] +is_a: GO:0010594 ! regulation of endothelial cell migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0010597 +name: green leaf volatile biosynthetic process +namespace: biological_process +def: "The biosynthesis of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163883] +is_a: GO:0019372 ! lipoxygenase pathway + +[Term] +id: GO:0010598 +name: NAD(P)H dehydrogenase complex (plastoquinone) +namespace: cellular_component +def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0010599 +name: RNA interference, production of lsiRNA +namespace: biological_process +def: "Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861] +is_a: GO:0031050 ! dsRNA fragmentation +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0010600 +name: regulation of auxin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] +is_a: GO:0046885 ! regulation of hormone biosynthetic process +relationship: regulates GO:0009851 ! auxin biosynthetic process + +[Term] +id: GO:0010601 +name: positive regulation of auxin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] +is_a: GO:0010600 ! regulation of auxin biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +relationship: positively_regulates GO:0009851 ! auxin biosynthetic process + +[Term] +id: GO:0010602 +name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process +namespace: biological_process +def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613] +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0033238 ! regulation of amine metabolic process +relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process + +[Term] +id: GO:0010603 +name: regulation of cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0043254 ! regulation of protein complex assembly +relationship: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly + +[Term] +id: GO:0010604 +name: positive regulation of macromolecule metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: positively_regulates GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0010605 +name: negative regulation of macromolecule metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0010606 +name: positive regulation of cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly + +[Term] +id: GO:0010607 +name: negative regulation of cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly + +[Term] +id: GO:0010608 +name: posttranscriptional regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression + +[Term] +id: GO:0010609 +name: posttranscriptional regulation of gene expression by mRNA localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb] +is_a: GO:0008298 ! intracellular mRNA localization +is_a: GO:0010608 ! posttranscriptional regulation of gene expression + +[Term] +id: GO:0010610 +name: regulation of mRNA stability involved in response to stress +namespace: biological_process +def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb] +is_a: GO:0043488 ! regulation of mRNA stability +relationship: part_of GO:0006950 ! response to stress + +[Term] +id: GO:0010611 +name: regulation of cardiac muscle hypertrophy +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] +is_a: GO:0010612 ! regulation of cardiac muscle adaptation +is_a: GO:0014743 ! regulation of muscle hypertrophy +relationship: regulates GO:0014898 ! cardiac muscle hypertrophy + +[Term] +id: GO:0010612 +name: regulation of cardiac muscle adaptation +namespace: biological_process +def: "Any process that modulates the rate, extent or frequency of the process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0010613 +name: positive regulation of cardiac muscle hypertrophy +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] +is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy +is_a: GO:0010615 ! positive regulation of cardiac muscle adaptation +is_a: GO:0014742 ! positive regulation of muscle hypertrophy +relationship: positively_regulates GO:0014898 ! cardiac muscle hypertrophy + +[Term] +id: GO:0010614 +name: negative regulation of cardiac muscle hypertrophy +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] +is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy +is_a: GO:0010616 ! negative regulation of cardiac muscle adaptation +is_a: GO:0014741 ! negative regulation of muscle hypertrophy +relationship: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy + +[Term] +id: GO:0010615 +name: positive regulation of cardiac muscle adaptation +namespace: biological_process +def: "Any process that increases the rate, extent or frequency of the process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] +is_a: GO:0010612 ! regulation of cardiac muscle adaptation +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0010616 +name: negative regulation of cardiac muscle adaptation +namespace: biological_process +def: "Any process that decreases the rate, extent or frequency of the process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] +is_a: GO:0010612 ! regulation of cardiac muscle adaptation +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0010617 +name: circadian regulation of calcium ion oscillation +namespace: biological_process +def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000] +synonym: " circadian regulation of Ca2+ oscillation" RELATED [] +synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED [] +synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb] +synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED [] +is_a: GO:0007623 ! circadian rhythm +is_a: GO:0051480 ! cytosolic calcium ion homeostasis + +[Term] +id: GO:0010618 +name: aerenchyma formation +namespace: biological_process +def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702] +is_a: GO:0048646 ! anatomical structure formation + +[Term] +id: GO:0010619 +name: activation of adenylate cyclase activity involved in G-protein signaling by glucose +namespace: biological_process +def: "Any glucose-triggered process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb] +synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010580 ! activation of adenylate cyclase activity involved in G-protein signaling + +[Term] +id: GO:0010620 +name: negative regulation of transcription by transcription factor catabolism +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a transcription factor." [GOC:dph, GOC:tb] +is_a: GO:0044257 ! cellular protein catabolic process +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent + +[Term] +id: GO:0010621 +name: negative regulation of transcription by transcription factor localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent + +[Term] +id: GO:0010622 +name: specification of ovule identity +namespace: biological_process +def: "The regionalization process by which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0048482 ! ovule morphogenesis + +[Term] +id: GO:0010623 +name: developmental programmed cell death +namespace: biological_process +def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb] +is_a: GO:0012501 ! programmed cell death +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0010624 +name: regulation of Schwann cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0060251 ! regulation of glial cell proliferation +relationship: regulates GO:0014010 ! Schwann cell proliferation + +[Term] +id: GO:0010625 +name: positive regulation of Schwann cell proliferation +namespace: biological_process +def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0010624 ! regulation of Schwann cell proliferation +is_a: GO:0060252 ! positive regulation of glial cell proliferation +relationship: positively_regulates GO:0014010 ! Schwann cell proliferation + +[Term] +id: GO:0010626 +name: negative regulation of Schwann cell proliferation +namespace: biological_process +def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0010624 ! regulation of Schwann cell proliferation +is_a: GO:0060253 ! negative regulation of glial cell proliferation +relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation + +[Term] +id: GO:0010627 +name: regulation of protein kinase cascade +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0010628 +name: positive regulation of gene expression +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +relationship: positively_regulates GO:0010467 ! gene expression + +[Term] +id: GO:0010629 +name: negative regulation of gene expression +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +relationship: negatively_regulates GO:0010467 ! gene expression + +[Term] +id: GO:0010630 +name: regulation of transcription, start site selection +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb] +is_a: GO:0045449 ! regulation of transcription + +[Term] +id: GO:0010631 +name: epithelial cell migration +namespace: biological_process +def: "The orderly movement of epithelial cells from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0010632 +name: regulation of epithelial cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:dph, GOC:tb] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0010633 +name: negative regulation of epithelial cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell migration." [GOC:dph, GOC:tb] +is_a: GO:0010632 ! regulation of epithelial cell migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0010634 +name: positive regulation of epithelial cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:dph, GOC:tb] +is_a: GO:0010632 ! regulation of epithelial cell migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0010635 +name: regulation of mitochondrial fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0008053 ! mitochondrial fusion + +[Term] +id: GO:0010636 +name: positive regulation of mitochondrial fusion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] +is_a: GO:0010635 ! regulation of mitochondrial fusion +is_a: GO:0010638 ! positive regulation of organelle organization +relationship: positively_regulates GO:0008053 ! mitochondrial fusion + +[Term] +id: GO:0010637 +name: negative regulation of mitochondrial fusion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] +is_a: GO:0010635 ! regulation of mitochondrial fusion +is_a: GO:0010639 ! negative regulation of organelle organization +relationship: negatively_regulates GO:0008053 ! mitochondrial fusion + +[Term] +id: GO:0010638 +name: positive regulation of organelle organization +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] +synonym: "positive regulation of organelle organization and biogenesis" EXACT [] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0006996 ! organelle organization + +[Term] +id: GO:0010639 +name: negative regulation of organelle organization +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] +synonym: "negative regulation of organelle organization and biogenesis" EXACT [] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0006996 ! organelle organization + +[Term] +id: GO:0010640 +name: regulation of platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0010641 +name: positive regulation of platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway +relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0010642 +name: negative regulation of platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0010643 +name: cell communication by chemical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0007154 ! cell communication + +[Term] +id: GO:0010644 +name: cell communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0007154 ! cell communication + +[Term] +id: GO:0010645 +name: regulation of cell communication by chemical coupling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +relationship: regulates GO:0010643 ! cell communication by chemical coupling + +[Term] +id: GO:0010646 +name: regulation of cell communication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007154 ! cell communication + +[Term] +id: GO:0010647 +name: positive regulation of cell communication +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0007154 ! cell communication + +[Term] +id: GO:0010648 +name: negative regulation of cell communication +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0007154 ! cell communication + +[Term] +id: GO:0010649 +name: regulation of cell communication by electrical coupling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +relationship: regulates GO:0010644 ! cell communication by electrical coupling + +[Term] +id: GO:0010650 +name: positive regulation of cell communication by electrical coupling +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0010649 ! regulation of cell communication by electrical coupling +relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling + +[Term] +id: GO:0010651 +name: negative regulation of cell communication by electrical coupling +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0010649 ! regulation of cell communication by electrical coupling +relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling + +[Term] +id: GO:0010652 +name: positive regulation of cell communication by chemical coupling +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010645 ! regulation of cell communication by chemical coupling +is_a: GO:0010647 ! positive regulation of cell communication +relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling + +[Term] +id: GO:0010653 +name: negative regulation of cell communication by chemical coupling +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010645 ! regulation of cell communication by chemical coupling +is_a: GO:0010648 ! negative regulation of cell communication +relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling + +[Term] +id: GO:0010654 +name: apical cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy + +[Term] +id: GO:0010655 +name: thrombin receptor activity, G-protein coupled +namespace: molecular_function +def: "Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:dph, GOC:tb] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled +is_a: GO:0015057 ! thrombin receptor activity + +[Term] +id: GO:0010656 +name: negative regulation of muscle cell apoptosis +namespace: biological_process +def: "Any process that decreases the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0010660 ! regulation of muscle cell apoptosis +is_a: GO:0043066 ! negative regulation of apoptosis +relationship: negatively_regulates GO:0010657 ! muscle cell apoptosis + +[Term] +id: GO:0010657 +name: muscle cell apoptosis +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [GOC:dph, GOC:tb] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0010658 +name: striated muscle cell apoptosis +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [GOC:dph, GOC:tb] +is_a: GO:0010657 ! muscle cell apoptosis + +[Term] +id: GO:0010659 +name: cardiac muscle cell apoptosis +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:dph, GOC:tb] +is_a: GO:0010658 ! striated muscle cell apoptosis + +[Term] +id: GO:0010660 +name: regulation of muscle cell apoptosis +namespace: biological_process +def: "Any process that modulates the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0042981 ! regulation of apoptosis +relationship: regulates GO:0010657 ! muscle cell apoptosis + +[Term] +id: GO:0010661 +name: positive regulation of muscle cell apoptosis +namespace: biological_process +def: "Any process that increases the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0010660 ! regulation of muscle cell apoptosis +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: positively_regulates GO:0010657 ! muscle cell apoptosis + +[Term] +id: GO:0010662 +name: regulation of striated muscle cell apoptosis +namespace: biological_process +def: "Any process that modulates the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0010660 ! regulation of muscle cell apoptosis +relationship: regulates GO:0010658 ! striated muscle cell apoptosis + +[Term] +id: GO:0010663 +name: positive regulation of striated muscle cell apoptosis +namespace: biological_process +def: "Any process that increases the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0010661 ! positive regulation of muscle cell apoptosis +is_a: GO:0010662 ! regulation of striated muscle cell apoptosis +relationship: positively_regulates GO:0010658 ! striated muscle cell apoptosis + +[Term] +id: GO:0010664 +name: negative regulation of striated muscle cell apoptosis +namespace: biological_process +def: "Any process that increases the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:rl, GOC:tb] +synonym: "down regulation of striated muscle cell apoptosis " EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of striated muscle cell apoptosis " NARROW [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0010656 ! negative regulation of muscle cell apoptosis +is_a: GO:0010662 ! regulation of striated muscle cell apoptosis +relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptosis + +[Term] +id: GO:0010665 +name: regulation of cardiac muscle cell apoptosis +namespace: biological_process +def: "Any process that modulates the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0010662 ! regulation of striated muscle cell apoptosis +relationship: regulates GO:0010659 ! cardiac muscle cell apoptosis + +[Term] +id: GO:0010666 +name: positive regulation of cardiac muscle cell apoptosis +namespace: biological_process +def: "Any process that increases the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:tb] +is_a: GO:0010663 ! positive regulation of striated muscle cell apoptosis +is_a: GO:0010665 ! regulation of cardiac muscle cell apoptosis +relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptosis + +[Term] +id: GO:0010667 +name: negative regulation of cardiac muscle cell apoptosis +namespace: biological_process +def: "Any process that decreases the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:rl, GOC:tb] +synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of cardiac muscle cell apoptosis " NARROW [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0010664 ! negative regulation of striated muscle cell apoptosis +is_a: GO:0010665 ! regulation of cardiac muscle cell apoptosis +relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptosis + +[Term] +id: GO:0010668 +name: ectodermal cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007398 ! ectoderm development + +[Term] +id: GO:0010669 +name: epithelial structure maintenance +namespace: biological_process +def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0010670 +name: positive regulation of oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:dph, GOC:tb] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process +relationship: positively_regulates GO:0006800 ! oxygen and reactive oxygen species metabolic process + +[Term] +id: GO:0010671 +name: negative regulation of oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:dph, GOC:tb] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process +relationship: negatively_regulates GO:0006800 ! oxygen and reactive oxygen species metabolic process + +[Term] +id: GO:0010672 +name: regulation of transcription from RNA polymerase II promoter, meiotic +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0010673 +name: positive regulation of transcription from RNA polymerase II promoter, meiotic +namespace: biological_process +def: "A cell cycle process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb] +is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter, meiotic +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0010674 +name: negative regulation of transcription from RNA polymerase II promoter, meiotic +namespace: biological_process +def: "A cell cycle process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter, meiotic + +[Term] +id: GO:0010675 +name: regulation of cellular carbohydrate metabolic process +namespace: biological_process +def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0010676 +name: positive regulation of cellular carbohydrate metabolic process +namespace: biological_process +def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0010677 +name: negative regulation of cellular carbohydrate metabolic process +namespace: biological_process +def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0010678 +name: negative regulation of cellular carbohydrate metabolic process by repression of transcription +namespace: biological_process +def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb] +synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0016481 ! negative regulation of transcription + +[Term] +id: GO:0010679 +name: cinnamic acid biosynthetic process involved in salicylic acid metabolism +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb] +is_a: GO:0009800 ! cinnamic acid biosynthetic process +relationship: part_of GO:0009696 ! salicylic acid metabolic process + +[Term] +id: GO:0010680 +name: cinnamic acid biosynthetic process involved in coumarin metabolism +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb] +is_a: GO:0009800 ! cinnamic acid biosynthetic process +relationship: part_of GO:0009804 ! coumarin metabolic process + +[Term] +id: GO:0010681 +name: cinnamic biosynthetic process involved in stilbene metabolism +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb] +is_a: GO:0009800 ! cinnamic acid biosynthetic process +relationship: part_of GO:0009810 ! stilbene metabolic process + +[Term] +id: GO:0010682 +name: cinnamic acid biosynthetic process involved in flavonoid metabolism +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb] +is_a: GO:0009800 ! cinnamic acid biosynthetic process +relationship: part_of GO:0009812 ! flavonoid metabolic process + +[Term] +id: GO:0010683 +name: tricyclic triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] +synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators] +is_a: GO:0006722 ! triterpenoid metabolic process + +[Term] +id: GO:0010684 +name: tricyclic triterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] +synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators] +is_a: GO:0010683 ! tricyclic triterpenoid metabolic process +is_a: GO:0016105 ! triterpenoid catabolic process + +[Term] +id: GO:0010685 +name: tetracyclic triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] +synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators] +is_a: GO:0006722 ! triterpenoid metabolic process + +[Term] +id: GO:0010686 +name: tetracyclic triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] +synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] +is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process + +[Term] +id: GO:0010687 +name: cytokinesis during cell cycle, site selection +namespace: biological_process +def: "The process of marking the place where cytokinesis will occur in the context of cell cycle progression." [GOC:dph, GOC:tb] +is_a: GO:0007105 ! cytokinesis, site selection +relationship: part_of GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0010688 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb] +is_a: GO:0010553 ! negative regulation of specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0010689 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb] +is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0010690 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb] +is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0010691 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb] +is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter +is_a: GO:0031669 ! cellular response to nutrient levels + +[Term] +id: GO:0010692 +name: regulation of alkaline phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0010693 +name: negative regulation of alkaline phosphatase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] +is_a: GO:0010692 ! regulation of alkaline phosphatase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0010694 +name: positive regulation of alkaline phosphatase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] +is_a: GO:0010692 ! regulation of alkaline phosphatase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0010695 +name: regulation of spindle pole body separation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] +synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0000073 ! spindle pole body separation + +[Term] +id: GO:0010696 +name: positive regulation of spindle pole body separation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] +synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010695 ! regulation of spindle pole body separation +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0000073 ! spindle pole body separation + +[Term] +id: GO:0010697 +name: negative regulation of spindle pole body separation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] +synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010695 ! regulation of spindle pole body separation +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0000073 ! spindle pole body separation + +[Term] +id: GO:0010698 +name: acetyltransferase activator activity +namespace: molecular_function +def: "Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:18690240] +synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0010699 +name: cell-cell signaling involved in quorum sensing +namespace: biological_process +def: "The cell-cell signaling process in which single-celled organisms monitor population density by detecting the concentration of small diffusible signal molecules." [GOC:dph, GOC:tb] +synonym: "cell-cell signalling involved in quorum sensing" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0009372 ! quorum sensing + +[Term] +id: GO:0010700 +name: negative regulation of norepinephrine secretion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] +is_a: GO:0014061 ! regulation of norepinephrine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion +relationship: negatively_regulates GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0010701 +name: positive regulation of norepinephrine secretion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] +is_a: GO:0014061 ! regulation of norepinephrine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion +relationship: positively_regulates GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0010702 +name: regulation of histolysis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007559 ! histolysis + +[Term] +id: GO:0010703 +name: negative regulation of histolysis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:dph, GOC:rl, GOC:tb] +synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0010702 ! regulation of histolysis +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007559 ! histolysis + +[Term] +id: GO:0010704 +name: meiotic DNA double-strand break processing involved in meiotic gene conversion +namespace: biological_process +def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000706 ! meiotic DNA double-strand break processing +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010705 +name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination +namespace: biological_process +def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000706 ! meiotic DNA double-strand break processing +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010706 +name: biosynthesis of lactosylceramide precursor to ganglioside +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group as a precursor of gangliosides." [GOC:dph, GOC:tb] +synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb] +synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001572 ! lactosylceramide biosynthetic process +is_a: GO:0001574 ! ganglioside biosynthetic process + +[Term] +id: GO:0010707 +name: biosynthesis of lactosylceramide precursor to globoside +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group as a precursor of globosides." [GOC:dph, GOC:tb] +synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb] +synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001572 ! lactosylceramide biosynthetic process +is_a: GO:0001576 ! globoside biosynthetic process + +[Term] +id: GO:0010708 +name: heteroduplex formation involved in gene conversion at mating-type locus +namespace: biological_process +def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the conversion of the mating-type locus from one allele to another." [GOC:dph, GOC:tb] +is_a: GO:0030491 ! heteroduplex formation +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0010709 +name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing +namespace: biological_process +def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb] +is_a: GO:0030491 ! heteroduplex formation +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:0010710 +name: regulation of collagen catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] +synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010712 ! regulation of collagen metabolic process +relationship: regulates GO:0030574 ! collagen catabolic process + +[Term] +id: GO:0010711 +name: negative regulation of collagen catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] +synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010710 ! regulation of collagen catabolic process +is_a: GO:0010713 ! negative regulation of collagen metabolic process +relationship: negatively_regulates GO:0030574 ! collagen catabolic process + +[Term] +id: GO:0010712 +name: regulation of collagen metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] +synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] +is_a: GO:0044246 ! regulation of multicellular organismal metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0010713 +name: negative regulation of collagen metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010712 ! regulation of collagen metabolic process +is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process +relationship: negatively_regulates GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0010714 +name: positive regulation of collagen metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010712 ! regulation of collagen metabolic process +is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process +relationship: positively_regulates GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0010715 +name: regulation of extracellular matrix disassembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] +synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0022617 ! extracellular matrix disassembly + +[Term] +id: GO:0010716 +name: negative regulation of extracellular matrix disassembly +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] +synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] +synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] +synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] +synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010715 ! regulation of extracellular matrix disassembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly + +[Term] +id: GO:0010717 +name: regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +relationship: regulates GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0010718 +name: positive regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb] +is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition +is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0010719 +name: negative regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb] +is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition +is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation +relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0010720 +name: positive regulation of cell development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: positively_regulates GO:0048468 ! cell development + +[Term] +id: GO:0010721 +name: negative regulation of cell development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: negatively_regulates GO:0048468 ! cell development + +[Term] +id: GO:0010722 +name: regulation of ferrochelatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb] +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0010723 +name: positive regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron + +[Term] +id: GO:0010724 +name: regulation of definitive erythrocyte differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: regulates GO:0060318 ! definitive erythrocyte differentiation + +[Term] +id: GO:0010725 +name: regulation of primitive erythrocyte differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0045646 ! regulation of erythrocyte differentiation +is_a: GO:0045995 ! regulation of embryonic development +relationship: regulates GO:0060319 ! primitive erythrocyte differentiation + +[Term] +id: GO:0010726 +name: positive regulation of hydrogen peroxide metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:0010670 ! positive regulation of oxygen and reactive oxygen species metabolic process +relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process + +[Term] +id: GO:0010727 +name: negative regulation of hydrogen peroxide metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:0010671 ! negative regulation of oxygen and reactive oxygen species metabolic process +relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process + +[Term] +id: GO:0010728 +name: regulation of hydrogen peroxide biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process + +[Term] +id: GO:0010729 +name: positive regulation of hydrogen peroxide biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process +is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process + +[Term] +id: GO:0010730 +name: negative regulation of hydrogen peroxide biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process +is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process + +[Term] +id: GO:0010731 +name: protein amino acid glutathionylation +namespace: biological_process +def: "The protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0010732 +name: regulation of protein amino acid glutathionylation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0010731 ! protein amino acid glutathionylation + +[Term] +id: GO:0010733 +name: positive regulation of protein amino acid glutathionylation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0010732 ! regulation of protein amino acid glutathionylation +is_a: GO:0031401 ! positive regulation of protein modification process +relationship: positively_regulates GO:0010731 ! protein amino acid glutathionylation + +[Term] +id: GO:0010734 +name: negative regulation of protein amino acid glutathionylation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0010732 ! regulation of protein amino acid glutathionylation +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0010731 ! protein amino acid glutathionylation + +[Term] +id: GO:0010735 +name: positive regulation of transcription via serum response element binding +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0010736 +name: serum response element binding +namespace: molecular_function +def: "Interacting selectively with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0010737 +name: protein kinase A signaling cascade +namespace: biological_process +def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +synonym: "PKA signaling cascade" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0010738 +name: regulation of protein kinase A signaling cascade +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the protein kinase A signaling cascade. The PKA signaling cascade is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +synonym: "regulation of PKA signaling cascade" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: regulates GO:0010737 ! protein kinase A signaling cascade + +[Term] +id: GO:0010739 +name: positive regulation of protein kinase A signaling cascade +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the protein kinase A signaling cascade. The PKA signaling cascade is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +synonym: "positive regulation of PKA signaling cascade" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010738 ! regulation of protein kinase A signaling cascade +is_a: GO:0010740 ! positive regulation of protein kinase cascade +relationship: positively_regulates GO:0010737 ! protein kinase A signaling cascade + +[Term] +id: GO:0010740 +name: positive regulation of protein kinase cascade +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: positively_regulates GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0010741 +name: negative regulation of protein kinase cascade +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: negatively_regulates GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0010742 +name: foam cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized monocyte acquires the specialized features of a foam cell. A foam cell is a macrophage containing lipid in small vacuoles." [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0010743 +name: regulation of foam cell differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of foam cell differentiation. Foam cell differentiation is the process whereby a relatively unspecialized monocyte acquires the specialized features of a foam cell. A foam cell is a macrophage containing lipid in small vacuoles." [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0045649 ! regulation of macrophage differentiation +relationship: regulates GO:0010742 ! foam cell differentiation + +[Term] +id: GO:0010744 +name: positive regulation of foam cell differentiation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of foam cell differentiation. Foam cell differentiation is the process whereby a relatively unspecialized monocyte acquires the specialized features of a foam cell. A foam cell is a macrophage containing lipid in small vacuoles." [GOC:dph, GOC:tb] +is_a: GO:0010743 ! regulation of foam cell differentiation +is_a: GO:0045651 ! positive regulation of macrophage differentiation +relationship: positively_regulates GO:0010742 ! foam cell differentiation + +[Term] +id: GO:0010745 +name: negative regulation of foam cell differentiation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of foam cell differentiation. Foam cell differentiation is the process whereby a relatively unspecialized monocyte acquires the specialized features of a foam cell. A foam cell is a macrophage containing lipid in small vacuoles." [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0010743 ! regulation of foam cell differentiation +is_a: GO:0045650 ! negative regulation of macrophage differentiation +relationship: negatively_regulates GO:0010742 ! foam cell differentiation + +[Term] +id: GO:0010746 +name: regulation of plasma membrane long-chain fatty acid transport +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:dph, GOC:tb] +is_a: GO:0032368 ! regulation of lipid transport +relationship: regulates GO:0015911 ! plasma membrane long-chain fatty acid transport + +[Term] +id: GO:0010747 +name: positive regulation of plasma membrane long-chain fatty acid transport +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:dph, GOC:tb] +is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport +is_a: GO:0032370 ! positive regulation of lipid transport +relationship: positively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport + +[Term] +id: GO:0010748 +name: negative regulation of plasma membrane long-chain fatty acid transport +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:dph, GOC:tb] +is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport +is_a: GO:0032369 ! negative regulation of lipid transport +relationship: negatively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport + +[Term] +id: GO:0010749 +name: regulation of nitric oxide mediated signal transduction +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:dph, GOC:tb] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction + +[Term] +id: GO:0010750 +name: positive regulation of nitric oxide mediated signal transduction +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:dph, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction +relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction + +[Term] +id: GO:0010751 +name: negative regulation of nitric oxide mediated signal transduction +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:dph, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction +relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction + +[Term] +id: GO:0010752 +name: regulation of cGMP-mediated signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:dph, GOC:tb] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0010753 +name: positive regulation of cGMP-mediated signaling +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:dph, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0010752 ! regulation of cGMP-mediated signaling +relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0010754 +name: negative regulation of cGMP-mediated signaling +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:dph, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010752 ! regulation of cGMP-mediated signaling +relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0010755 +name: regulation of plasminogen activation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process whereby plasminogen is processed to plasmin." [GOC:dph, GOC:tb] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0031639 ! plasminogen activation + +[Term] +id: GO:0010756 +name: positive regulation of plasminogen activation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process whereby plasminogen is processed to plasmin." [GOC:dph, GOC:tb] +is_a: GO:0010755 ! regulation of plasminogen activation +is_a: GO:0031401 ! positive regulation of protein modification process +relationship: positively_regulates GO:0031639 ! plasminogen activation + +[Term] +id: GO:0010757 +name: negative regulation of plasminogen activation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process whereby plasminogen is processed to plasmin." [GOC:dph, GOC:tb] +synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb] +is_a: GO:0010755 ! regulation of plasminogen activation +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0031639 ! plasminogen activation + +[Term] +id: GO:0010758 +name: regulation of macrophage chemotaxis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +relationship: regulates GO:0048246 ! macrophage chemotaxis + +[Term] +id: GO:0010759 +name: positive regulation of macrophage chemotaxis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0010758 ! regulation of macrophage chemotaxis +relationship: positively_regulates GO:0048246 ! macrophage chemotaxis + +[Term] +id: GO:0010760 +name: negative regulation of macrophage chemotaxis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:0010758 ! regulation of macrophage chemotaxis +relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis + +[Term] +id: GO:0010761 +name: fibroblast cell migration +namespace: biological_process +def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:dph, GOC:tb] +is_a: GO:0001667 ! ameboidal cell migration + +[Term] +id: GO:0010762 +name: regulation of fibroblast cell migration +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0010761 ! fibroblast cell migration + +[Term] +id: GO:0010763 +name: positive regulation of fibroblast cell migration +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] +is_a: GO:0010762 ! regulation of fibroblast cell migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0010761 ! fibroblast cell migration + +[Term] +id: GO:0010764 +name: negative regulation of fibroblast cell migration +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] +is_a: GO:0010762 ! regulation of fibroblast cell migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0010761 ! fibroblast cell migration + +[Term] +id: GO:0010765 +name: positive regulation of sodium ion transport +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells." [GOC:dph, GOC:tb] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0010766 +name: negative regulation of sodium ion transport +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells." [GOC:dph, GOC:tb] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0010767 +name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] +is_a: GO:0009411 ! response to UV +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0010768 +name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage + +[Term] +id: GO:0010769 +name: regulation of cell morphogenesis involved in differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0010770 +name: positive regulation of cell morphogenesis involved in differentiation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0010771 +name: negative regulation of cell morphogenesis involved in differentiation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0010772 +name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000707 ! meiotic DNA recombinase assembly +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010773 +name: meiotic DNA recombinase assembly involved in meiotic gene conversion +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000707 ! meiotic DNA recombinase assembly +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010774 +name: meiotic strand invasion involved in reciprocal meiotic recombination +namespace: biological_process +def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000708 ! meiotic strand invasion +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010775 +name: meiotic strand invasion involved in meiotic gene conversion +namespace: biological_process +def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb] +is_a: GO:0000708 ! meiotic strand invasion +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010776 +name: meiotic mismatch repair involved in meiotic gene conversion +namespace: biological_process +def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000710 ! meiotic mismatch repair +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010777 +name: meiotic mismatch repair involved in reciprocal meiotic recombination +namespace: biological_process +def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000710 ! meiotic mismatch repair +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010778 +name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination +namespace: biological_process +def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000711 ! meiotic DNA repair synthesis +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010779 +name: meiotic DNA repair synthesis involved in meiotic gene conversion +namespace: biological_process +def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000711 ! meiotic DNA repair synthesis +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010780 +name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +namespace: biological_process +def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0042138 ! meiotic DNA double-strand break formation +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010781 +name: meiotic DNA double-strand break formation involved in meiotic gene conversion +namespace: biological_process +def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0042138 ! meiotic DNA double-strand break formation +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010782 +name: proboscis morphogenesis, labial disc-derived +namespace: biological_process +def: "The process by which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007454 ! labial disc morphogenesis +relationship: part_of GO:0048734 ! proboscis morphogenesis + +[Term] +id: GO:0010783 +name: proboscis morphogenesis, eye-antennal disc-derived +namespace: biological_process +def: "The process by which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis +relationship: part_of GO:0048734 ! proboscis morphogenesis + +[Term] +id: GO:0010784 +name: proboscis morphogenesis, clypeo-labral disc-derived +namespace: biological_process +def: "The process by which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048734 ! proboscis morphogenesis + +[Term] +id: GO:0010785 +name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting +namespace: biological_process +def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048202 ! clathrin coating of Golgi vesicle +relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome + +[Term] +id: GO:0010786 +name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting +namespace: biological_process +def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048202 ! clathrin coating of Golgi vesicle +relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome + +[Term] +id: GO:0010787 +name: COPI coating of Golgi vesicle, inter-Golgi cisterna +namespace: biological_process +def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048205 ! COPI coating of Golgi vesicle +relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna + +[Term] +id: GO:0010788 +name: COPI coating of Golgi vesicle, cis-Golgi to rough ER +namespace: biological_process +def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048205 ! COPI coating of Golgi vesicle +relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough ER + +[Term] +id: GO:0010789 +name: meiotic sister chromatid cohesion involved in meiosis I +namespace: biological_process +def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb] +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0010790 +name: meiotic sister chromatid cohesion involved in meiosis II +namespace: biological_process +def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb] +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0010791 +name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb] +is_a: GO:0000729 ! DNA double-strand break processing +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:0010792 +name: DNA double-strand break processing involved in repair via single-strand annealing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb] +is_a: GO:0000729 ! DNA double-strand break processing +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0010793 +name: regulation of mRNA export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0046831 ! regulation of RNA export from nucleus +relationship: regulates GO:0006406 ! mRNA export from nucleus + +[Term] +id: GO:0010794 +name: regulation of dolichol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0019408 ! dolichol biosynthetic process + +[Term] +id: GO:0010795 +name: regulation of ubiquinone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: regulates GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0010796 +name: regulation of multivesicular body size +namespace: biological_process +def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0051036 ! regulation of endosome size + +[Term] +id: GO:0010797 +name: regulation of multivesicular body size involved in endosome transport +namespace: biological_process +def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] +is_a: GO:0010796 ! regulation of multivesicular body size +relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway + +[Term] +id: GO:0010798 +name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism +namespace: biological_process +def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb] +is_a: GO:0010796 ! regulation of multivesicular body size + +[Term] +id: GO:0010799 +name: regulation of peptidyl-threonine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0010800 +name: positive regulation of peptidyl-threonine phosphorylation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] +is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation +is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation +relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0010801 +name: negative regulation of peptidyl-threonine phosphorylation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] +is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation +is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation +relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0010802 +name: respiratory gaseous exchange by respiratory system +namespace: biological_process +def: "The process of gaseous exchange between an organism and its environment carried out by the organism's respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:tb] +is_a: GO:0003016 ! respiratory system process +is_a: GO:0007585 ! respiratory gaseous exchange + +[Term] +id: GO:0010803 +name: regulation of tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] +synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway + +[Term] +id: GO:0010804 +name: negative regulation of tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] +synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001960 ! negative regulation of cytokine mediated signaling pathway +is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway +relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway + +[Term] +id: GO:0010805 +name: regulation of lysine import +namespace: biological_process +def: "Any process that modulates the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0034226 ! lysine import + +[Term] +id: GO:0010806 +name: negative regulation of lysine import +namespace: biological_process +def: "Any process that decreases the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010805 ! regulation of lysine import +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0051956 ! negative regulation of amino acid transport +relationship: negatively_regulates GO:0034226 ! lysine import + +[Term] +id: GO:0010807 +name: regulation of synaptic vesicle priming +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kva, GOC:tb, PMID:15489511] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0043254 ! regulation of protein complex assembly +is_a: GO:0046928 ! regulation of neurotransmitter secretion +relationship: regulates GO:0016082 ! synaptic vesicle priming + +[Term] +id: GO:0010808 +name: positive regulation of synaptic vesicle priming +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kva, GOC:tb, PMID:15489511] +is_a: GO:0010807 ! regulation of synaptic vesicle priming +is_a: GO:0031334 ! positive regulation of protein complex assembly +relationship: positively_regulates GO:0016082 ! synaptic vesicle priming + +[Term] +id: GO:0010809 +name: negative regulation of synaptic vesicle priming +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kva, GOC:tb, PMID:15489511] +is_a: GO:0010807 ! regulation of synaptic vesicle priming +is_a: GO:0031333 ! negative regulation of protein complex assembly +relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming + +[Term] +id: GO:0010810 +name: regulation of cell-substrate adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0010811 +name: positive regulation of cell-substrate adhesion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] +is_a: GO:0010810 ! regulation of cell-substrate adhesion +is_a: GO:0045785 ! positive regulation of cell adhesion +relationship: positively_regulates GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0010812 +name: negative regulation of cell-substrate adhesion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0010810 ! regulation of cell-substrate adhesion +relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0010813 +name: neuropeptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:dph, GOC:tb] +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0010814 +name: substance P catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:rl] +is_a: GO:0010813 ! neuropeptide catabolic process + +[Term] +id: GO:0010815 +name: bradykinin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:rl] +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0010816 +name: calcitonin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:rl] +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0010817 +name: regulation of hormone levels +namespace: biological_process +def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:dph, GOC:tb] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0010818 +name: T cell chemotaxis +namespace: biological_process +def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] +is_a: GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:0010819 +name: regulation of T cell chemotaxis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +relationship: regulates GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0010820 +name: positive regulation of T cell chemotaxis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0010819 ! regulation of T cell chemotaxis +relationship: positively_regulates GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0012501 +name: programmed cell death +namespace: biological_process +def: "Cell death resulting from activation of endogenous cellular processes." [GOC:lr] +comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. +synonym: "necrosis" RELATED [] +is_a: GO:0008219 ! cell death + +[Term] +id: GO:0012502 +name: induction of programmed cell death +namespace: biological_process +def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr] +is_a: GO:0043068 ! positive regulation of programmed cell death + +[Term] +id: GO:0012503 +name: induction of non-apoptotic programmed cell death +namespace: biological_process +def: "A process which directly activates any of the steps required for non-apoptotic programmed cell death." [GOC:lr] +synonym: "induction of nonapoptotic programmed cell death" EXACT [] +is_a: GO:0012502 ! induction of programmed cell death +is_a: GO:0043071 ! positive regulation of non-apoptotic programmed cell death + +[Term] +id: GO:0012504 +name: induction of non-apoptotic programmed cell death by other organism +namespace: biological_process +def: "A process which directly activates any of the steps required for non-apoptotic programmed cell death in another organism." [GOC:curators, GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0012503 ! induction of non-apoptotic programmed cell death +is_a: GO:0052044 ! induction by symbiont of host programmed cell death +is_a: GO:0052153 ! positive regulation by symbiont of host non-apoptotic programmed cell death +is_a: GO:0052397 ! induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0012505 +name: endomembrane system +namespace: cellular_component +def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] +subset: goslim_candida +subset: goslim_yeast +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0012506 +name: vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0012505 ! endomembrane system +relationship: part_of GO:0031988 ! membrane-bounded vesicle + +[Term] +id: GO:0012507 +name: ER to Golgi transport vesicle membrane +namespace: cellular_component +alt_id: GO:0030664 +def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai] +synonym: "COPII coated vesicle membrane" EXACT [] +synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] +synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] +synonym: "ER-Golgi transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030660 ! Golgi-associated vesicle membrane +is_a: GO:0030662 ! coated vesicle membrane +relationship: part_of GO:0030134 ! ER to Golgi transport vesicle + +[Term] +id: GO:0012508 +name: Golgi to ER transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai] +synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT [] +synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT [] +synonym: "Golgi-ER transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030663 ! COPI coated vesicle membrane +relationship: part_of GO:0030142 ! Golgi to ER transport vesicle + +[Term] +id: GO:0012509 +name: inter-Golgi transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030663 ! COPI coated vesicle membrane +relationship: part_of GO:0030143 ! inter-Golgi transport vesicle + +[Term] +id: GO:0012510 +name: trans-Golgi network transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] +synonym: "TGN transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030660 ! Golgi-associated vesicle membrane +is_a: GO:0030665 ! clathrin coated vesicle membrane +relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle + +[Term] +id: GO:0012511 +name: monolayer-surrounded lipid storage body +namespace: cellular_component +alt_id: GO:0009520 +def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. A droplet of triacylglycerol surrounded by a monolayer of phospholipids, interacting with the triacylglycerols and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] +synonym: "lipid storage body (sensu Viridiplantae)" EXACT [] +synonym: "oil body" EXACT [] +synonym: "oilbody" EXACT [] +synonym: "oleosome" EXACT [] +synonym: "spherosome" EXACT [] +is_a: GO:0005811 ! lipid particle +is_a: GO:0043229 ! intracellular organelle + +[Term] +id: GO:0014001 +name: sclerenchyma cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. Plant cell type with thick lignified walls, normally dead at maturity and specialised for structural strength. Includes fibre cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplast at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jic, http://cancerweb.ncl.ac.uk, PO:0000077] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0014002 +name: astrocyte development +namespace: biological_process +def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] +synonym: "astrocyte cell development" EXACT [] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0014003 +name: oligodendrocyte development +namespace: biological_process +def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] +synonym: "oligodendrocyte cell development" EXACT [] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0014004 +name: microglia differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] +synonym: "microglial cell differentiation" EXACT [] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0014005 +name: microglia development +namespace: biological_process +def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] +synonym: "microglial cell development" EXACT [] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014006 +name: regulation of microglia differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] +synonym: "regulation of microglial cell differentiation" EXACT [] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014007 +name: negative regulation of microglia differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] +synonym: "down regulation of microglia differentiation" EXACT [] +synonym: "down-regulation of microglia differentiation" EXACT [] +synonym: "downregulation of microglia differentiation" EXACT [] +synonym: "inhibition of microglia differentiation" NARROW [] +synonym: "negative regulation of microglial cell differentiation" EXACT [] +is_a: GO:0014006 ! regulation of microglia differentiation +is_a: GO:0045686 ! negative regulation of glial cell differentiation +relationship: negatively_regulates GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014008 +name: positive regulation of microglia differentiation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] +synonym: "activation of microglia differentiation" NARROW [] +synonym: "positive regulation of microglial cell differentiation" EXACT [] +synonym: "stimulation of microglia differentiation" NARROW [] +synonym: "up regulation of microglia differentiation" EXACT [] +synonym: "up-regulation of microglia differentiation" EXACT [] +synonym: "upregulation of microglia differentiation" EXACT [] +is_a: GO:0014006 ! regulation of microglia differentiation +is_a: GO:0045687 ! positive regulation of glial cell differentiation +relationship: positively_regulates GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014009 +name: glial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] +synonym: "glia proliferation" EXACT [] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0014010 +name: Schwann cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] +is_a: GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0014011 +name: Schwann cell proliferation involved in axon regeneration +namespace: biological_process +def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585] +is_a: GO:0014010 ! Schwann cell proliferation +relationship: part_of GO:0014012 ! axon regeneration in the peripheral nervous system + +[Term] +id: GO:0014012 +name: axon regeneration in the peripheral nervous system +namespace: biological_process +def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef] +is_a: GO:0031103 ! axon regeneration + +[Term] +id: GO:0014013 +name: regulation of gliogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] +is_a: GO:0050767 ! regulation of neurogenesis +relationship: regulates GO:0042063 ! gliogenesis + +[Term] +id: GO:0014014 +name: negative regulation of gliogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] +synonym: "down regulation of gliogenesis" EXACT [] +synonym: "down-regulation of gliogenesis" EXACT [] +synonym: "downregulation of gliogenesis" EXACT [] +synonym: "inhibition of gliogenesis" NARROW [] +is_a: GO:0014013 ! regulation of gliogenesis +is_a: GO:0050768 ! negative regulation of neurogenesis +relationship: negatively_regulates GO:0042063 ! gliogenesis + +[Term] +id: GO:0014015 +name: positive regulation of gliogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] +synonym: "activation of gliogenesis" NARROW [] +synonym: "stimulation of gliogenesis" NARROW [] +synonym: "up regulation of gliogenesis" EXACT [] +synonym: "up-regulation of gliogenesis" EXACT [] +synonym: "upregulation of gliogenesis" EXACT [] +is_a: GO:0014013 ! regulation of gliogenesis +is_a: GO:0050769 ! positive regulation of neurogenesis +relationship: positively_regulates GO:0042063 ! gliogenesis + +[Term] +id: GO:0014016 +name: neuroblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] +is_a: GO:0048863 ! stem cell differentiation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0014017 +name: neuroblast fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] +is_a: GO:0048865 ! stem cell fate commitment +relationship: part_of GO:0014016 ! neuroblast differentiation + +[Term] +id: GO:0014018 +name: neuroblast fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] +is_a: GO:0048866 ! stem cell fate specification +relationship: part_of GO:0014017 ! neuroblast fate commitment + +[Term] +id: GO:0014019 +name: neuroblast development +namespace: biological_process +def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] +is_a: GO:0048864 ! stem cell development +relationship: part_of GO:0014016 ! neuroblast differentiation + +[Term] +id: GO:0014020 +name: primary neural tube formation +namespace: biological_process +def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] +synonym: "primary neurulation" EXACT [] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0001841 ! neural tube formation + +[Term] +id: GO:0014021 +name: secondary neural tube formation +namespace: biological_process +alt_id: GO:0014026 +def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585] +synonym: "medullary cord biosynthesis" EXACT [] +synonym: "medullary cord formation" EXACT [] +synonym: "neural rod formation (sensu Mus)" NARROW [] +synonym: "secondary neural tube formation (sensu Mus)" EXACT [] +synonym: "secondary neurulation" EXACT [] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0001841 ! neural tube formation + +[Term] +id: GO:0014022 +name: neural plate elongation +namespace: biological_process +def: "The process by which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +relationship: part_of GO:0001839 ! neural plate morphogenesis + +[Term] +id: GO:0014023 +name: neural rod formation +namespace: biological_process +def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] +synonym: "neural rod formation (sensu Teleost)" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0014024 +name: neural rod cavitation +namespace: biological_process +def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] +synonym: "neural rod cavitation (sensu Teleost)" EXACT [] +is_a: GO:0035148 ! lumen formation +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0014025 +name: neural keel formation +namespace: biological_process +def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0014023 ! neural rod formation + +[Term] +id: GO:0014027 +name: secondary neural tube rod cavitation +namespace: biological_process +def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] +synonym: "medullary rod cavitation" EXACT [] +is_a: GO:0035148 ! lumen formation +relationship: part_of GO:0014021 ! secondary neural tube formation + +[Term] +id: GO:0014028 +name: notochord formation +namespace: biological_process +def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007399 ! nervous system development +relationship: part_of GO:0048570 ! notochord morphogenesis + +[Term] +id: GO:0014029 +name: neural crest formation +namespace: biological_process +def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef] +is_a: GO:0001837 ! epithelial to mesenchymal transition +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0014030 +name: mesenchymal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0014031 +name: mesenchymal cell development +namespace: biological_process +def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0014032 +name: neural crest cell development +namespace: biological_process +def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] +is_a: GO:0014031 ! mesenchymal cell development +relationship: part_of GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:0014033 +name: neural crest cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] +is_a: GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0014034 +name: neural crest cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0014029 ! neural crest formation +relationship: part_of GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:0014035 +name: neural crest cell fate determination +namespace: biological_process +def: "The process by which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0014034 ! neural crest cell fate commitment + +[Term] +id: GO:0014036 +name: neural crest cell fate specification +namespace: biological_process +def: "The process by which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0014034 ! neural crest cell fate commitment + +[Term] +id: GO:0014037 +name: Schwann cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007422 ! peripheral nervous system development + +[Term] +id: GO:0014038 +name: regulation of Schwann cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014039 +name: negative regulation of Schwann cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] +synonym: "down regulation of Schwann cell differentiation" EXACT [] +synonym: "down-regulation of Schwann cell differentiation" EXACT [] +synonym: "downregulation of Schwann cell differentiation" EXACT [] +synonym: "inhibition of Schwann cell differentiation" NARROW [] +is_a: GO:0014038 ! regulation of Schwann cell differentiation +is_a: GO:0045686 ! negative regulation of glial cell differentiation +relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014040 +name: positive regulation of Schwann cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] +synonym: "activation of Schwann cell differentiation" NARROW [] +synonym: "stimulation of Schwann cell differentiation" NARROW [] +synonym: "up regulation of Schwann cell differentiation" EXACT [] +synonym: "up-regulation of Schwann cell differentiation" EXACT [] +synonym: "upregulation of Schwann cell differentiation" EXACT [] +is_a: GO:0014038 ! regulation of Schwann cell differentiation +is_a: GO:0045687 ! positive regulation of glial cell differentiation +relationship: positively_regulates GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014041 +name: regulation of neuron maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0042551 ! neuron maturation + +[Term] +id: GO:0014042 +name: positive regulation of neuron maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] +synonym: "activation of neuron maturation" NARROW [] +synonym: "stimulation of neuron maturation" NARROW [] +synonym: "up regulation of neuron maturation" EXACT [] +synonym: "up-regulation of neuron maturation" EXACT [] +synonym: "upregulation of neuron maturation" EXACT [] +is_a: GO:0014041 ! regulation of neuron maturation +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0042551 ! neuron maturation + +[Term] +id: GO:0014043 +name: negative regulation of neuron maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] +synonym: "down regulation of neuron maturation" EXACT [] +synonym: "down-regulation of neuron maturation" EXACT [] +synonym: "downregulation of neuron maturation" EXACT [] +synonym: "inhibition of neuron maturation" NARROW [] +is_a: GO:0014041 ! regulation of neuron maturation +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0042551 ! neuron maturation + +[Term] +id: GO:0014044 +name: Schwann cell development +namespace: biological_process +def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014045 +name: establishment of blood-brain barrier +namespace: biological_process +def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh] +synonym: "establishment of blood/brain barrier" EXACT [] +is_a: GO:0001885 ! endothelial cell development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0014046 +name: dopamine secretion +namespace: biological_process +def: "The regulated release of dopamine by a cell or group of cells. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] +is_a: GO:0015872 ! dopamine transport +is_a: GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0014047 +name: glutamate secretion +namespace: biological_process +def: "The regulated release of glutamate by a cell or group of cells. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] +is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0014048 +name: regulation of glutamate secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of glutamate." [GOC:ef] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0014047 ! glutamate secretion + +[Term] +id: GO:0014049 +name: positive regulation of glutamate secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glutamate." [GOC:ef] +synonym: "activation of glutamate secretion" NARROW [] +synonym: "stimulation of glutamate secretion" NARROW [] +synonym: "up regulation of glutamate secretion" EXACT [] +synonym: "up-regulation of glutamate secretion" EXACT [] +synonym: "upregulation of glutamate secretion" EXACT [] +is_a: GO:0014048 ! regulation of glutamate secretion +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0014047 ! glutamate secretion + +[Term] +id: GO:0014050 +name: negative regulation of glutamate secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of glutamate." [GOC:ef] +synonym: "down regulation of glutamate secretion" EXACT [] +synonym: "down-regulation of glutamate secretion" EXACT [] +synonym: "downregulation of glutamate secretion" EXACT [] +synonym: "inhibition of glutamate secretion" NARROW [] +is_a: GO:0014048 ! regulation of glutamate secretion +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0014047 ! glutamate secretion + +[Term] +id: GO:0014051 +name: gamma-aminobutyric acid secretion +namespace: biological_process +def: "The regulated release of gamm-aminobutyric acid by a cell or group of cells. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] +synonym: "GABA secretion" EXACT [] +is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling +is_a: GO:0015812 ! gamma-aminobutyric acid transport + +[Term] +id: GO:0014052 +name: regulation of gamma-aminobutyric acid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] +synonym: "regulation of GABA secretion" EXACT [] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014053 +name: negative regulation of gamma-aminobutyric acid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] +synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] +synonym: "negative regulation of GABA secretion" EXACT [] +is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051956 ! negative regulation of amino acid transport +relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014054 +name: positive regulation of gamma-aminobutyric acid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] +synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] +synonym: "positive regulation of GABA secretion" EXACT [] +synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] +synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] +is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051957 ! positive regulation of amino acid transport +relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014055 +name: acetylcholine secretion +namespace: biological_process +def: "The regulated release of acetylcholine by a cell or group of cells. The acetylcholine is a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0015870 ! acetylcholine transport + +[Term] +id: GO:0014056 +name: regulation of acetylcholine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0014055 ! acetylcholine secretion + +[Term] +id: GO:0014057 +name: positive regulation of acetylcholine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] +synonym: "activation of acetylcholine secretion" NARROW [] +synonym: "stimulation of acetylcholine secretion" NARROW [] +synonym: "up regulation of acetylcholine secretion" EXACT [] +synonym: "up-regulation of acetylcholine secretion" EXACT [] +synonym: "upregulation of acetylcholine secretion" EXACT [] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:0014056 ! regulation of acetylcholine secretion +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0014055 ! acetylcholine secretion + +[Term] +id: GO:0014058 +name: negative regulation of acetylcholine secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] +synonym: "down regulation of acetylcholine secretion" EXACT [] +synonym: "down-regulation of acetylcholine secretion" EXACT [] +synonym: "downregulation of acetylcholine secretion" EXACT [] +synonym: "inhibition of acetylcholine secretion" NARROW [] +is_a: GO:0014056 ! regulation of acetylcholine secretion +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0014055 ! acetylcholine secretion + +[Term] +id: GO:0014059 +name: regulation of dopamine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] +is_a: GO:0050433 ! regulation of catecholamine secretion +relationship: regulates GO:0014046 ! dopamine secretion + +[Term] +id: GO:0014060 +name: regulation of epinephrine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef] +synonym: "regulation of adrenaline secretion" EXACT [] +is_a: GO:0050433 ! regulation of catecholamine secretion +relationship: regulates GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0014061 +name: regulation of norepinephrine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] +synonym: "regulation of noradrenaline secretion" EXACT [] +is_a: GO:0050433 ! regulation of catecholamine secretion +relationship: regulates GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0014062 +name: regulation of serotonin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0001820 ! serotonin secretion + +[Term] +id: GO:0014063 +name: negative regulation of serotonin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] +synonym: "down regulation of serotonin secretion" EXACT [] +synonym: "down-regulation of serotonin secretion" EXACT [] +synonym: "downregulation of serotonin secretion" EXACT [] +synonym: "inhibition of serotonin secretion" NARROW [] +is_a: GO:0014062 ! regulation of serotonin secretion +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0001820 ! serotonin secretion + +[Term] +id: GO:0014064 +name: positive regulation of serotonin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] +synonym: "activation of serotonin secretion" NARROW [] +synonym: "stimulation of serotonin secretion" NARROW [] +synonym: "up regulation of serotonin secretion" EXACT [] +synonym: "up-regulation of serotonin secretion" EXACT [] +synonym: "upregulation of serotonin secretion" EXACT [] +is_a: GO:0014062 ! regulation of serotonin secretion +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0001820 ! serotonin secretion + +[Term] +id: GO:0014065 +name: phosphoinositide 3-kinase cascade +namespace: biological_process +def: "A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions." [GOC:ef, http://en.wikipedia.org "Wikipedia", http://www.biocarta.com] +synonym: "PI 3-kinase cascade" EXACT [] +synonym: "PI3K cascade" EXACT [] +is_a: GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0014066 +name: regulation of phosphoinositide 3-kinase cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade." [GOC:ef] +synonym: "regulation of PI 3-kinase cascade" RELATED [] +synonym: "regulation of PI3K cascade" EXACT [] +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: regulates GO:0014065 ! phosphoinositide 3-kinase cascade + +[Term] +id: GO:0014067 +name: negative regulation of phosphoinositide 3-kinase cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade." [GOC:ef] +synonym: "down regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "down-regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "downregulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "inhibition of phosphoinositide 3-kinase cascade" NARROW [] +synonym: "negative regulation of PI 3-kinase cascade" EXACT [] +synonym: "negative regulation of PI3K cascade" EXACT [] +is_a: GO:0010741 ! negative regulation of protein kinase cascade +is_a: GO:0014066 ! regulation of phosphoinositide 3-kinase cascade +relationship: negatively_regulates GO:0014065 ! phosphoinositide 3-kinase cascade + +[Term] +id: GO:0014068 +name: positive regulation of phosphoinositide 3-kinase cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade." [GOC:ef] +synonym: "activation of phosphoinositide 3-kinase cascade" NARROW [] +synonym: "positive regulation of PI 3-kinase cascade" EXACT [] +synonym: "positive regulation of PI3K cascade" EXACT [] +synonym: "stimulation of phosphoinositide 3-kinase cascade" NARROW [] +synonym: "up regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "up-regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "upregulation of phosphoinositide 3-kinase cascade" EXACT [] +is_a: GO:0010740 ! positive regulation of protein kinase cascade +is_a: GO:0014066 ! regulation of phosphoinositide 3-kinase cascade +relationship: positively_regulates GO:0014065 ! phosphoinositide 3-kinase cascade + +[Term] +id: GO:0014069 +name: postsynaptic density +namespace: cellular_component +def: "The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases." [GOC:ef, GOC:jic, http://molneuro.kaist.ac.kr/psd, http://wikipedia.org, PMID:14532281] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044456 ! synapse part + +[Term] +id: GO:0014070 +name: response to organic cyclic substance +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic substance stimulus." [CHEBI:33832, GOC:ef] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0014071 +name: response to cycloalkane +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [CHEBI:23453, GOC:ef] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0014072 +name: response to isoquinoline alkaloid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [CHEBI:24921, GOC:ef, http://cancerweb.ncl.ac.uk] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0014073 +name: response to tropane +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [CHEBI:35615, GOC:ef] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0014074 +name: response to purine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine stimulus. Aside from DNA and RNA, purines are biochemically significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A." [CHEBI:26401, GOC:ef] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0014075 +name: response to amine stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [CHEBI:32952, GOC:ef] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0014076 +name: response to fluoxetine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [CHEBI:5118, GOC:ef] +synonym: "selective serotonin reuptake inhibitor" EXACT [] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0014701 +name: junctional sarcoplasmic reticulum membrane +namespace: cellular_component +def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] +is_a: GO:0033017 ! sarcoplasmic reticulum membrane + +[Term] +id: GO:0014702 +name: free sarcoplasmic reticulum membrane +namespace: cellular_component +def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] +is_a: GO:0033017 ! sarcoplasmic reticulum membrane + +[Term] +id: GO:0014703 +name: oscillatory muscle contraction +namespace: biological_process +def: "A process whereby force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The oscillatory muscle contraction occurs in insect wing muscles and it is charactirised by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle] +is_a: GO:0003010 ! voluntary skeletal muscle contraction + +[Term] +id: GO:0014704 +name: intercalated disc +namespace: cellular_component +def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0014705 +name: C zone +namespace: cellular_component +def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0031672 ! A band + +[Term] +id: GO:0014706 +name: striated muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:mtg_muscle] +is_a: GO:0007517 ! muscle development + +[Term] +id: GO:0014707 +name: branchiomeric skeletal muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle] +is_a: GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0014708 +name: regulation of somitomeric trunk muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle] +is_a: GO:0048641 ! regulation of skeletal muscle development +relationship: regulates GO:0002075 ! somitomeric trunk muscle development + +[Term] +id: GO:0014709 +name: positive regulation of somitomeric trunk muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014708 ! regulation of somitomeric trunk muscle development +is_a: GO:0048643 ! positive regulation of skeletal muscle development +relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development + +[Term] +id: GO:0014710 +name: negative regulation of somitomeric trunk muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014708 ! regulation of somitomeric trunk muscle development +is_a: GO:0048642 ! negative regulation of skeletal muscle development +relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development + +[Term] +id: GO:0014711 +name: regulation of branchiomeric skeletal muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] +is_a: GO:0048641 ! regulation of skeletal muscle development +relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development + +[Term] +id: GO:0014712 +name: positive regulation of branchiomeric skeletal muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] +is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development +is_a: GO:0048643 ! positive regulation of skeletal muscle development +relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development + +[Term] +id: GO:0014713 +name: negative regulation of branchiomeric skeletal muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] +is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development +is_a: GO:0048642 ! negative regulation of skeletal muscle development +relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development + +[Term] +id: GO:0014714 +name: myoblast cell fate commitment in head +namespace: biological_process +def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0048625 ! myoblast cell fate commitment + +[Term] +id: GO:0014715 +name: myoblast cell fate commitment in trunk +namespace: biological_process +def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0048625 ! myoblast cell fate commitment + +[Term] +id: GO:0014716 +name: satellite cell asymmetric division involved in skeletal muscle regeneration +namespace: biological_process +def: "Satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fibre, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] +is_a: GO:0014833 ! satellite cell asymmetric division +relationship: part_of GO:0014834 ! satellite cell maintenance involved in skeletal muscle regeneration + +[Term] +id: GO:0014717 +name: regulation of satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] +is_a: GO:0043416 ! regulation of skeletal muscle regeneration +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:0014718 +name: positive regulation of satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] +is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration +is_a: GO:0050867 ! positive regulation of cell activation +relationship: part_of GO:0043415 ! positive regulation of skeletal muscle regeneration +relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:0014719 +name: satellite cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a satellite cell resulting from exposure to an activating factor such as a cellular or soluble ligand. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fibre, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0014720 +name: tonic skeletal muscle contraction +namespace: biological_process +def: "A process whereby force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle] +is_a: GO:0003010 ! voluntary skeletal muscle contraction + +[Term] +id: GO:0014721 +name: twitch skeletal muscle contraction +namespace: biological_process +def: "A process whereby force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle] +is_a: GO:0003010 ! voluntary skeletal muscle contraction + +[Term] +id: GO:0014722 +name: regulation of skeletal muscle contraction by calcium ion signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle] +synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT [] +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0014723 +name: regulation of skeletal muscle contraction via modulation of calcium ion sensitivity of myofibril +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle] +synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT [] +is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling + +[Term] +id: GO:0014724 +name: regulation of twitch skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction +relationship: regulates GO:0014721 ! twitch skeletal muscle contraction + +[Term] +id: GO:0014725 +name: regulation of extraocular skeletal muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0048641 ! regulation of skeletal muscle development +relationship: regulates GO:0002074 ! extraocular skeletal muscle development + +[Term] +id: GO:0014726 +name: negative regulation of extraocular skeletal muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014725 ! regulation of extraocular skeletal muscle development +is_a: GO:0048642 ! negative regulation of skeletal muscle development +relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development + +[Term] +id: GO:0014727 +name: positive regulation of extraocular skeletal muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014725 ! regulation of extraocular skeletal muscle development +is_a: GO:0048643 ! positive regulation of skeletal muscle development +relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development + +[Term] +id: GO:0014728 +name: regulation of the force of skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle] +is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion + +[Term] +id: GO:0014729 +name: regulation of the velocity of shortening of skeletal muscle during contraction +namespace: biological_process +def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle] +is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0014730 +name: skeletal muscle regeneration at neuromuscular junction +namespace: biological_process +def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibres regenerate after injury and they form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibres develop within the basal lamina sheaths (satellite cells) of original myofibres." [GOC:mtg_muscle] +is_a: GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014731 +name: spectrin-associated cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0014732 +name: skeletal muscle atrophy +namespace: biological_process +def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0014891 ! striated muscle atrophy +is_a: GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0014733 +name: regulation of skeletal muscle adaptation +namespace: biological_process +def: "Any process by which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] +synonym: "regulation of skeletal muscle plasticity" RELATED [] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0014734 +name: skeletal muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] +is_a: GO:0014897 ! striated muscle hypertrophy +is_a: GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0014735 +name: regulation of muscle atrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014736 +name: negative regulation of muscle atrophy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle] +is_a: GO:0014735 ! regulation of muscle atrophy +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014737 +name: positive regulation of muscle atrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] +is_a: GO:0014735 ! regulation of muscle atrophy +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014738 +name: regulation of muscle hyperplasia +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014739 +name: positive regulation of muscle hyperplasia +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] +is_a: GO:0014738 ! regulation of muscle hyperplasia +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014740 +name: negative regulation of muscle hyperplasia +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle] +is_a: GO:0014738 ! regulation of muscle hyperplasia +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014741 +name: negative regulation of muscle hypertrophy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014742 +name: positive regulation of muscle hypertrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014743 +name: regulation of muscle hypertrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014744 +name: positive regulation of muscle adaptation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] +synonym: "positive regulation of muscle plasticity" RELATED [] +is_a: GO:0043502 ! regulation of muscle adaptation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014745 +name: negative regulation of muscle adaptation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] +synonym: "negative regulation of muscle plasticity" RELATED [] +is_a: GO:0043502 ! regulation of muscle adaptation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014746 +name: regulation of tonic skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction +relationship: regulates GO:0014720 ! tonic skeletal muscle contraction + +[Term] +id: GO:0014747 +name: positive regulation of tonic skeletal muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction + +[Term] +id: GO:0014748 +name: negative regulation of tonic skeletal muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction + +[Term] +id: GO:0014801 +name: longitudinal sarcoplasmic reticulum +namespace: cellular_component +def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0014802 +name: terminal cisterna +namespace: cellular_component +def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle] +is_a: GO:0031984 ! organelle subcompartment +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0014803 +name: longitudinal sarcoplasmic reticulum lumen +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lume contained within the terminal cisternae." [GOC:mtg_muscle] +is_a: GO:0033018 ! sarcoplasmic reticulum lumen +relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum + +[Term] +id: GO:0014804 +name: terminal cisterna lumen +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle] +is_a: GO:0033018 ! sarcoplasmic reticulum lumen +relationship: part_of GO:0014802 ! terminal cisterna + +[Term] +id: GO:0014805 +name: smooth muscle adaptation +namespace: biological_process +def: "Any process by which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] +synonym: "smooth muscle plasticity" RELATED [] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014806 +name: smooth muscle hyperplasia +namespace: biological_process +def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] +is_a: GO:0014805 ! smooth muscle adaptation + +[Term] +id: GO:0014807 +name: regulation of somitogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] +is_a: GO:0045995 ! regulation of embryonic development +relationship: regulates GO:0001756 ! somitogenesis + +[Term] +id: GO:0014808 +name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum +namespace: biological_process +def: "The process whereby the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle] +synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0014809 +name: regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk] +is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling +relationship: part_of GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum + +[Term] +id: GO:0014810 +name: positive regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] +is_a: GO:0014809 ! regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion +is_a: GO:0045989 ! positive regulation of striated muscle contraction + +[Term] +id: GO:0014811 +name: negative regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] +is_a: GO:0014809 ! regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion +is_a: GO:0045988 ! negative regulation of striated muscle contraction + +[Term] +id: GO:0014812 +name: muscle cell migration +namespace: biological_process +def: "The orderly movement of muscle cells from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0014813 +name: satellite cell commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0014816 ! satellite cell differentiation + +[Term] +id: GO:0014814 +name: axon regeneration at neuromuscular junction +namespace: biological_process +def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibres similar to normal ones." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0031103 ! axon regeneration + +[Term] +id: GO:0014815 +name: initiation of satellite cell activation by growth factor signalling, involved in skeletal muscle regeneration +namespace: biological_process +def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fibre, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:0014816 +name: satellite cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0014817 +name: satellite cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0014813 ! satellite cell commitment + +[Term] +id: GO:0014818 +name: satellite cell fate determination +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0014813 ! satellite cell commitment + +[Term] +id: GO:0014819 +name: regulation of skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0006942 ! regulation of striated muscle contraction +relationship: regulates GO:0003009 ! skeletal muscle contraction + +[Term] +id: GO:0014820 +name: tonic smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014821 +name: phasic smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014822 +name: detection of wounding +namespace: biological_process +def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle] +synonym: "detection of injury" EXACT [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0014823 +name: response to activity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle] +synonym: "response to exercise" RELATED [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0014824 +name: artery smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MESH:A07.231.114] +is_a: GO:0014820 ! tonic smooth muscle contraction +is_a: GO:0014829 ! vascular smooth muscle contraction + +[Term] +id: GO:0014825 +name: stomach fundus smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, MA:0001612] +is_a: GO:0014847 ! proximal stomach smooth muscle contraction + +[Term] +id: GO:0014826 +name: vein smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MESH:A07.231.908] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014829 ! vascular smooth muscle contraction + +[Term] +id: GO:0014827 +name: intestine smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MESH:A03.556.124] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0014828 +name: distal stomach smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, http://biology.about.com] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0014829 +name: vascular smooth muscle contraction +namespace: biological_process +def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718] +is_a: GO:0006939 ! smooth muscle contraction +is_a: GO:0042310 ! vasoconstriction + +[Term] +id: GO:0014830 +name: arteriole smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MESH:A07.231.114.060] +is_a: GO:0014824 ! artery smooth muscle contraction + +[Term] +id: GO:0014831 +name: gastro-intestinal system smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MESH:A03.556] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014832 +name: urinary bladder smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mtg_muscle, MA:0001697, MESH:A05.810.890] +is_a: GO:0014848 ! urinary tract smooth muscle contraction + +[Term] +id: GO:0014833 +name: satellite cell asymmetric division +namespace: biological_process +def: "The asymmetric division of a satellite cell that occurs when a satellite cell divides to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool. Satellite cells are quiescent adult muscle stem cells that become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0008356 ! asymmetric cell division +relationship: part_of GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0014834 +name: satellite cell maintenance involved in skeletal muscle regeneration +namespace: biological_process +def: "The process essential to maintain a ready source of satellite cells. It consists of the return of activated satellite cells to a quiescent state after proliferation to replenish the satellite cell pool. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fibre, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:16607119] +synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb] +synonym: "satellite cell population maintenance" EXACT [] +synonym: "satellite cell self-renewal" BROAD [] +is_a: GO:0035019 ! somatic stem cell maintenance +relationship: part_of GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014835 +name: myoblast cell differentiation involved in skeletal muscle regeneration +namespace: biological_process +def: "The process whereby a relatively unspecialized satellite cell acquires specialized features of a myoblast cell. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0045445 ! myoblast differentiation +relationship: part_of GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014836 +name: myoblast cell fate commitment involved in skeletal muscle regeneration +namespace: biological_process +def: "The process whereby the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast cell. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0048625 ! myoblast cell fate commitment +relationship: part_of GO:0014835 ! myoblast cell differentiation involved in skeletal muscle regeneration + +[Term] +id: GO:0014837 +name: myoblast cell fate determination involved in skeletal muscle regeneration +namespace: biological_process +def: "The process whereby a satellite cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0007518 ! myoblast cell fate determination +relationship: part_of GO:0014836 ! myoblast cell fate commitment involved in skeletal muscle regeneration + +[Term] +id: GO:0014838 +name: myoblast cell fate specification involved in skeletal muscle regeneration +namespace: biological_process +def: "The process whereby a satellite cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0048626 ! myoblast cell fate specification +relationship: part_of GO:0014836 ! myoblast cell fate commitment involved in skeletal muscle regeneration + +[Term] +id: GO:0014839 +name: myoblast migration involved in skeletal muscle regeneration +namespace: biological_process +def: "The process whereby a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD [] +is_a: GO:0051451 ! myoblast migration +relationship: part_of GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014841 +name: satellite cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fibre, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0014842 +name: regulation of satellite cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0014841 ! satellite cell proliferation + +[Term] +id: GO:0014843 +name: growth factor dependent regulation of satellite cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0014842 ! regulation of satellite cell proliferation + +[Term] +id: GO:0014844 +name: myoblast cell proliferation involved in skeletal muscle regeneration +namespace: biological_process +def: "The multiplication or reproduction of myoblast cells, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0051450 ! myoblast proliferation +relationship: part_of GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014845 +name: stomach body smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, MA:0002559] +is_a: GO:0014828 ! distal stomach smooth muscle contraction + +[Term] +id: GO:0014846 +name: esophagus smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MESH:A03.556.875.500] +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0014847 +name: proximal stomach smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, http://biology.about.com] +is_a: GO:0014820 ! tonic smooth muscle contraction +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0014848 +name: urinary tract smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, MA:0000325, MESH:A05.810] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014849 +name: ureter smooth muscle contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014848 ! urinary tract smooth muscle contraction + +[Term] +id: GO:0014850 +name: response to muscle activity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle] +is_a: GO:0014823 ! response to activity + +[Term] +id: GO:0014852 +name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0014853 +name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction +namespace: biological_process +def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0060079 ! regulation of excitatory postsynaptic membrane potential +relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction + +[Term] +id: GO:0014854 +name: response to inactivity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0014855 +name: striated muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] +is_a: GO:0033002 ! muscle cell proliferation + +[Term] +id: GO:0014856 +name: skeletal muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0014855 ! striated muscle cell proliferation + +[Term] +id: GO:0014857 +name: regulation of skeletal muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014858 +name: positive regulation of skeletal muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation +relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014859 +name: negative regulation of skeletal muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation +relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014860 +name: neurotransmitter secretion involved in regulation of skeletal muscle contraction +namespace: biological_process +def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb, http://cancerweb.ncl.ac.uk] +synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007269 ! neurotransmitter secretion +relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction + +[Term] +id: GO:0014861 +name: regulation of skeletal muscle contraction via membrane action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0014862 +name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0014863 +name: detection of inactivity +namespace: biological_process +def: "The series of events in which a inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014854 ! response to inactivity +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0014864 +name: detection of muscle activity +namespace: biological_process +def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014850 ! response to muscle activity +is_a: GO:0014865 ! detection of activity + +[Term] +id: GO:0014865 +name: detection of activity +namespace: biological_process +def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014823 ! response to activity +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0014866 +name: skeletal myofibril assembly +namespace: biological_process +def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0030239 ! myofibril assembly + +[Term] +id: GO:0014868 +name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "A process whereby cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction + +[Term] +id: GO:0014869 +name: detection of muscle inactivity +namespace: biological_process +def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014863 ! detection of inactivity +is_a: GO:0014870 ! response to muscle inactivity + +[Term] +id: GO:0014870 +name: response to muscle inactivity +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle] +is_a: GO:0014854 ! response to inactivity + +[Term] +id: GO:0014871 +name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "The process whereby actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction + +[Term] +id: GO:0014872 +name: myoblast cell division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0014873 +name: response to muscle activity involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to fatigue" EXACT [] +synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0014850 ! response to muscle activity +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation + +[Term] +id: GO:0014874 +name: response to stimulus involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0050896 ! response to stimulus +relationship: part_of GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014875 +name: detection of muscle activity involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "detection of fatigue" EXACT [] +is_a: GO:0014864 ! detection of muscle activity +is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation + +[Term] +id: GO:0014876 +name: response to injury involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to injury involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0009611 ! response to wounding +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation + +[Term] +id: GO:0014877 +name: response to muscle inactivity involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014870 ! response to muscle inactivity +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation + +[Term] +id: GO:0014878 +name: response to electrical stimulus involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation +is_a: GO:0051602 ! response to electrical stimulus + +[Term] +id: GO:0014879 +name: detection of electrical stimulus involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation +is_a: GO:0050981 ! detection of electrical stimulus + +[Term] +id: GO:0014880 +name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] +is_a: GO:0032971 ! regulation of muscle filament sliding +relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle during contraction + +[Term] +id: GO:0014881 +name: regulation of myofibril size +namespace: biological_process +def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] +synonym: "change of myofibril size" EXACT [] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0014882 +name: regulation of myofibril number +namespace: biological_process +def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] +synonym: "change of myofibril number" EXACT [] +is_a: GO:0014738 ! regulation of muscle hyperplasia +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0014883 +name: transition between fast and slow fiber +namespace: biological_process +def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] +synonym: "transition between fast and slow fibre" EXACT [] +synonym: "transition fast-slow fiber" EXACT [] +synonym: "transition fast-slow fibre" EXACT [] +is_a: GO:0014733 ! regulation of skeletal muscle adaptation + +[Term] +id: GO:0014884 +name: detection of muscle inactivity involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014869 ! detection of muscle inactivity +is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation + +[Term] +id: GO:0014885 +name: detection of injury involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "detection of injury involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0014822 ! detection of wounding +is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation + +[Term] +id: GO:0014886 +name: transition between slow and fast fiber +namespace: biological_process +def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] +synonym: "transition between slow and fast fibre" EXACT [] +synonym: "transition slow-fast fiber" EXACT [] +synonym: "transition slow-fast fibre" EXACT [] +is_a: GO:0014733 ! regulation of skeletal muscle adaptation + +[Term] +id: GO:0014887 +name: cardiac muscle adaptation +namespace: biological_process +def: "The process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] +synonym: "cardiac muscle plasticity" RELATED [] +is_a: GO:0014888 ! striated muscle adaptation + +[Term] +id: GO:0014888 +name: striated muscle adaptation +namespace: biological_process +def: "Any process by which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] +synonym: "striated muscle plasticity" RELATED [] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014889 +name: muscle atrophy +namespace: biological_process +def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fibre diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014890 +name: smooth muscle atrophy +namespace: biological_process +def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fibre diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0014805 ! smooth muscle adaptation +is_a: GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014891 +name: striated muscle atrophy +namespace: biological_process +def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0014888 ! striated muscle adaptation +is_a: GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014893 +name: response to rest involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] +is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation + +[Term] +id: GO:0014894 +name: response to denervation involved in regulation of muscle adaptation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] +is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation + +[Term] +id: GO:0014895 +name: smooth muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] +is_a: GO:0014805 ! smooth muscle adaptation +is_a: GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014896 +name: muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014897 +name: striated muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] +is_a: GO:0014888 ! striated muscle adaptation +is_a: GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014898 +name: cardiac muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. In the case of cardiac muscle cells this happens due to regular and increasing aerobic exercise." [GOC:mtg_muscle] +is_a: GO:0014887 ! cardiac muscle adaptation +is_a: GO:0014897 ! striated muscle hypertrophy + +[Term] +id: GO:0014899 +name: cardiac muscle atrophy +namespace: biological_process +def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle] +is_a: GO:0014887 ! cardiac muscle adaptation +is_a: GO:0014891 ! striated muscle atrophy + +[Term] +id: GO:0014900 +name: muscle hyperplasia +namespace: biological_process +def: "A process, occurring in muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014901 +name: satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "The process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fibre, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] +is_a: GO:0014719 ! satellite cell activation +relationship: part_of GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014902 +name: myotube differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0042692 ! muscle cell differentiation +relationship: part_of GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0014904 +name: myotube cell development +namespace: biological_process +def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0014902 ! myotube differentiation + +[Term] +id: GO:0014905 +name: myoblast fusion involved in skeletal muscle regeneration +namespace: biological_process +def: "A process whereby non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/] +is_a: GO:0007520 ! myoblast fusion +relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration + +[Term] +id: GO:0014906 +name: myotube cell development involved in skeletal muscle regeneration +namespace: biological_process +def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0014904 ! myotube cell development +relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration + +[Term] +id: GO:0014908 +name: myotube differentiation involved in skeletal muscle regeneration +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0014902 ! myotube differentiation +relationship: part_of GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0014909 +name: smooth muscle cell migration +namespace: biological_process +def: "The orderly movement of smooth muscle cells from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0014812 ! muscle cell migration + +[Term] +id: GO:0014910 +name: regulation of smooth muscle cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:0014911 +name: positive regulation of smooth muscle cell migration +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0014910 ! regulation of smooth muscle cell migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:0014912 +name: negative regulation of smooth muscle cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0014910 ! regulation of smooth muscle cell migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:0014914 +name: myoblast maturation involved in muscle regeneration +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0048628 ! myoblast maturation + +[Term] +id: GO:0014915 +name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] +is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction +is_a: GO:0032972 ! regulation of muscle filament sliding speed + +[Term] +id: GO:0014916 +name: regulation of lung blood pressure +namespace: biological_process +def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] +synonym: "regulation of pulmonary blood pressure" EXACT [] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0014917 +name: positive regulation of diuresis by pressure natriuresis +namespace: biological_process +def: "The process by which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio] +is_a: GO:0003103 ! positive regulation of diuresis +relationship: part_of GO:0003095 ! pressure natriuresis + +[Term] +id: GO:0014918 +name: positive regulation of natriuresis by pressure natriuresis +namespace: biological_process +def: "The process whereby pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio] +is_a: GO:0003079 ! positive regulation of natriuresis +relationship: part_of GO:0003095 ! pressure natriuresis + +[Term] +id: GO:0015000 +name: polyferredoxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015001 +name: high-potential iron-sulfur carrier +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "high-potential iron-sulphur carrier" EXACT [] +synonym: "HiPIP" RELATED [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015002 +name: heme-copper terminal oxidase activity +namespace: molecular_function +def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] +subset: gosubset_prok +synonym: "haem-copper terminal oxidase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0015003 +name: copper electron carrier +namespace: molecular_function +def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015004 +name: small blue copper electron carrier +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015005 +name: azurin +namespace: molecular_function +def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0015006 +name: plastocyanin +namespace: molecular_function +def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +replaced_by: GO:0046028 + +[Term] +id: GO:0015007 +name: electron carrier, chlorophyll electron transport system +namespace: molecular_function +def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it contains both process and function information. +synonym: "chlorophyll electron carrier" RELATED [] +is_obsolete: true +consider: GO:0009055 +consider: GO:0009767 + +[Term] +id: GO:0015009 +name: corrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "corrin metabolism" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0015010 +name: tetrahydrocorphin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [http://findarticles.com/p/articles/mi_m0841/is_n1_v28/ai_13746418, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44] +subset: gosubset_prok +synonym: "tetrahydrocorphin metabolism" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0015011 +name: nickel-tetrapyrrole coenzyme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44, http://www.chem.qmul.ac.uk/iupac/bioinorg/EG.html#33] +subset: gosubset_prok +synonym: "coenzyme F430 metabolic process" NARROW [] +synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0015010 ! tetrahydrocorphin metabolic process + +[Term] +id: GO:0015012 +name: heparan sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0198547684, RESID:AA0210] +subset: gosubset_prok +synonym: "heparan sulfate proteoglycan anabolism" EXACT [] +synonym: "heparan sulfate proteoglycan biosynthesis" EXACT [] +synonym: "heparan sulfate proteoglycan formation" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT [] +synonym: "heparin proteoglycan biosynthetic process" RELATED [] +xref: RESID:AA0210 +is_a: GO:0030166 ! proteoglycan biosynthetic process +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0015013 +name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide +namespace: biological_process +def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194] +subset: gosubset_prok +synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT [] +synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT [] +synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED [] +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process +relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0015014 +name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai] +subset: gosubset_prok +synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] +synonym: "heparan sulfate proteoglycan chain elongation" EXACT [] +synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] +synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0015015 +name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification +namespace: biological_process +def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194] +subset: gosubset_prok +synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT [] +synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT [] +synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED [] +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process +relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0015016 +name: [heparan sulfate]-glucosamine N-sulfotransferase activity +namespace: molecular_function +alt_id: GO:0004393 +alt_id: GO:0015022 +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-desulfoheparin = adenosine 3',5'-bisphosphate + heparin." [EC:2.8.2.8] +comment: Note that this activity includes EC:2.8.2.12 (deleted from EC). +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT [] +synonym: "desulfoheparin sulfotransferase activity" EXACT [] +synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED [] +synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED [] +synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT [] +synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "N-HSST activity" EXACT [EC:2.8.2.8] +synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8] +synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] +xref: EC:2.8.2.8 +xref: MetaCyc:DESULFOHEPARIN-SULFOTRANSFERASE-RXN +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0015017 +name: glypican +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan'). +is_obsolete: true + +[Term] +id: GO:0015018 +name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] +synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135] +synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] +synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] +synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135] +xref: EC:2.4.1.135 +xref: MetaCyc:2.4.1.135-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0015019 +name: heparan-alpha-glucosaminide N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78] +synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] +synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] +synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED [] +xref: EC:2.3.1.78 +xref: MetaCyc:2.3.1.78-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0015020 +name: glucuronosyltransferase activity +namespace: molecular_function +alt_id: GO:0003981 +def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] +synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "GT activity" EXACT [EC:2.4.1.17] +synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "phenyl-UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "Phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17] +synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17] +synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17] +synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17] +synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" EXACT [EC:2.4.1.17] +synonym: "UDPGT activity" EXACT [EC:2.4.1.17] +synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] +xref: EC:2.4.1.17 +xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN +xref: Reactome:9978 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0015021 +name: heparin-sulfate lyase activity +namespace: molecular_function +def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8] +subset: gosubset_prok +synonym: "[heparan sulfate]-sulfate lyase activity" RELATED [] +synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8] +synonym: "heparin-sulphate lyase activity" EXACT [] +synonym: "heparitin-sulfate lyase activity" EXACT [] +synonym: "heparitinase I" RELATED [EC:4.2.2.8] +synonym: "heparitinase II" RELATED [EC:4.2.2.8] +xref: EC:4.2.2.8 +xref: MetaCyc:4.2.2.8-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0015023 +name: syndecan +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0015024 +name: glucuronate-2-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18] +synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18] +synonym: "glucuronate-2-sulphatase activity" EXACT [] +synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18] +synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18] +xref: EC:3.1.6.18 +xref: MetaCyc:3.1.6.18-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0015025 +name: GPI-anchored membrane-bound receptor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0004872 +consider: GO:0019898 + +[Term] +id: GO:0015026 +name: coreceptor activity +namespace: molecular_function +def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0015027 +name: coreceptor, soluble ligand activity +namespace: molecular_function +is_a: GO:0015026 ! coreceptor activity + +[Term] +id: GO:0015028 +name: coreceptor, insoluble ligand activity +namespace: molecular_function +is_a: GO:0015026 ! coreceptor activity + +[Term] +id: GO:0015029 +name: internalization receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind. +is_obsolete: true + +[Term] +id: GO:0015030 +name: Cajal body +namespace: cellular_component +def: "A class of nuclear body, first seen after silver staining by Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [http://genetics.cwru.edu/matera3.html, PMID:10944589, PMID:11031238, PMID:7559785] +synonym: "coiled body" EXACT [] +synonym: "Gems" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0015031 +name: protein transport +namespace: biological_process +alt_id: GO:0015831 +def: "The directed movement of proteins into, out of, within or between cells." [GOC:ai] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +synonym: "enzyme transport" NARROW [] +is_a: GO:0006810 ! transport +is_a: GO:0045184 ! establishment of protein localization + +[Term] +id: GO:0015032 +name: storage protein import into fat body +namespace: biological_process +def: "The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363] +synonym: "fat body metabolic process (sensu Insecta)" RELATED [] +synonym: "fat body metabolism (sensu Insecta)" RELATED [] +synonym: "fat body storage protein uptake" EXACT [] +synonym: "import of storage protein into fat body" EXACT [] +synonym: "storage protein import by fat body cells" EXACT [] +synonym: "storage protein import into fat body cells" EXACT [] +synonym: "storage protein transport into fat body cells" EXACT [] +synonym: "storage protein uptake into fat body cells" EXACT [] +is_a: GO:0017038 ! protein import + +[Term] +id: GO:0015034 +name: cytochrome P450 activity +namespace: molecular_function +def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423] +comment: This term was made obsolete because it is a grouping term representing a set of gene products. +is_obsolete: true +consider: GO:0019825 + +[Term] +id: GO:0015035 +name: protein disulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN-] +subset: gosubset_prok +synonym: "protein disulphide oxidoreductase activity" EXACT [] +xref: MetaCyc:DISULFOXRED-RXN +is_a: GO:0015036 ! disulfide oxidoreductase activity + +[Term] +id: GO:0015036 +name: disulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction that interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate." [GOC:mah, MetaCyc:DISULFOXRED-RXN] +subset: gosubset_prok +synonym: "disulphide oxidoreductase activity" EXACT [] +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0015037 +name: peptide disulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN-] +subset: gosubset_prok +synonym: "peptide disulphide oxidoreductase activity" EXACT [] +is_a: GO:0015036 ! disulfide oxidoreductase activity + +[Term] +id: GO:0015038 +name: glutathione disulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] +subset: gosubset_prok +synonym: "glutaredoxin" RELATED [] +synonym: "glutathione disulphide oxidoreductase activity" EXACT [] +is_a: GO:0015037 ! peptide disulfide oxidoreductase activity + +[Term] +id: GO:0015039 +name: NADPH-adrenodoxin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.2, GOC:kd] +comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. +synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2] +synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] +synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2] +xref: EC:1.18.1.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0015040 +name: electron transfer flavoprotein, group I +namespace: molecular_function +def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015041 +name: electron transfer flavoprotein, group II +namespace: molecular_function +def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015042 +name: trypanothione-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12] +comment: Note that this function was formerly EC:1.6.4.8. +synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] +synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] +synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] +synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] +synonym: "trypanothione reductase activity" EXACT [] +synonym: "trypanothione-disulphide reductase activity" EXACT [] +synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12] +xref: EC:1.8.1.12 +xref: MetaCyc:1.8.1.12-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0015043 +name: leghemoglobin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6] +synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6] +synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6] +xref: EC:1.6.2.6 +xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN +is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor + +[Term] +id: GO:0015044 +name: rubredoxin-NAD+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1] +subset: gosubset_prok +synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] +synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1] +synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] +synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1] +synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] +synonym: "NADH:rubredoxin reductase activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] +synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1] +synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1] +synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1] +xref: EC:1.18.1.1 +xref: MetaCyc:RUBREDOXIN--NAD(+)-REDUCTASE-RXN +is_a: GO:0015046 ! rubredoxin reductase activity + +[Term] +id: GO:0015045 +name: rubredoxin-NAD(P)+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4] +synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4] +synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] +synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] +synonym: "NADPH:rubredoxin reductase activity" EXACT [] +synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4] +synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4] +synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4] +xref: EC:1.18.1.4 +xref: MetaCyc:RUBREDOXIN--NADP(+)-REDUCTASE-RXN +is_a: GO:0015046 ! rubredoxin reductase activity + +[Term] +id: GO:0015046 +name: rubredoxin reductase activity +namespace: molecular_function +def: "Catalysis of the reactions: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.-] +subset: gosubset_prok +xref: EC:1.18.1.- +is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor + +[Term] +id: GO:0015047 +name: NADPH-cytochrome-c2 reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5] +synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5] +synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5] +synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5] +xref: EC:1.6.2.5 +xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN +is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor + +[Term] +id: GO:0015048 +name: phthalate dioxygenase reductase activity +namespace: molecular_function +def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0015049 +name: methane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25] +subset: gosubset_prok +synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25] +synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25] +xref: EC:1.14.13.25 +xref: MetaCyc:METHANE-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0007 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0015050 +name: methane monooxygenase complex +namespace: cellular_component +def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0015051 +name: X-opioid receptor activity +namespace: molecular_function +is_a: GO:0004985 ! opioid receptor activity + +[Term] +id: GO:0015052 +name: beta3-adrenergic receptor activity +namespace: molecular_function +synonym: "beta3 adrenoceptor" EXACT [] +is_a: GO:0004939 ! beta-adrenergic receptor activity + +[Term] +id: GO:0015053 +name: opsin +namespace: molecular_function +def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007602 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015054 +name: gastrin receptor activity +namespace: molecular_function +def: "Combining with gastrin to initiate a change in cell activity." [GOC:ai] +synonym: "cholecystokinin-B receptor activity" EXACT [] +is_a: GO:0004951 ! cholecystokinin receptor activity + +[Term] +id: GO:0015055 +name: secretin receptor activity +namespace: molecular_function +def: "Combining with secretin to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0015056 +name: corticotrophin-releasing factor receptor activity +namespace: molecular_function +def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0015057 +name: thrombin receptor activity +namespace: molecular_function +def: "Combining with thrombin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0001653 ! peptide receptor activity + +[Term] +id: GO:0015058 +name: epidermal growth factor-like module containing hormone receptor activity +namespace: molecular_function +alt_id: GO:0016523 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "EGF-like module containing hormone receptor activity" EXACT [] +synonym: "Egr1 hormone receptor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015059 +name: blue-sensitive opsin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007603 +consider: GO:0009588 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015060 +name: green-sensitive opsin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007603 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015061 +name: red-sensitive opsin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007603 +consider: GO:0009585 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015062 +name: violet-sensitive opsin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007603 +consider: GO:0009588 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015063 +name: long-wave-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007603 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015064 +name: UV-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007604 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015065 +name: uridine nucleotide receptor activity +namespace: molecular_function +def: "Combining with UTP or UDP to initiate a change in cell activity." [UniProtKB:P51582] +synonym: "purinoceptor type U" EXACT [] +is_a: GO:0045028 ! purinergic nucleotide receptor activity, G-protein coupled + +[Term] +id: GO:0015066 +name: alpha-amylase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah] +subset: gosubset_prok +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0015067 +name: amidinotransferase activity +namespace: molecular_function +def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai] +subset: gosubset_prok +synonym: "transamidinase activity" EXACT [] +xref: EC:2.1.4.- +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0015068 +name: glycine amidinotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1] +subset: gosubset_prok +synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1] +synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1] +synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1] +synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1] +xref: EC:2.1.4.1 +xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN +xref: Reactome:19902 +is_a: GO:0015067 ! amidinotransferase activity + +[Term] +id: GO:0015069 +name: scyllo-inosamine-4-phosphate amidinotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate." [EC:2.1.4.2] +subset: gosubset_prok +synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2] +synonym: "inosamine-phosphate amidinotransferase activity" EXACT [] +synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] +synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] +synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2] +xref: EC:2.1.4.2 +xref: MetaCyc:2.1.4.2-RXN +is_a: GO:0015067 ! amidinotransferase activity + +[Term] +id: GO:0015070 +name: toxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl, http://cancerweb.ncl.ac.uk/] +comment: This term was made obsolete because it represents a classification of molecules and not a molecular function. +is_obsolete: true +consider: GO:0009405 +consider: GO:0050827 + +[Term] +id: GO:0015072 +name: phosphatidylinositol 3-kinase, class I, catalyst activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0016303 +replaced_by: GO:0035005 +replaced_by: GO:0046934 + +[Term] +id: GO:0015073 +name: phosphatidylinositol 3-kinase, class I, regulator activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] +comment: This term was made obsolete because it refers to a class of gene products. +is_obsolete: true +replaced_by: GO:0046935 + +[Term] +id: GO:0015074 +name: DNA integration +namespace: biological_process +def: "The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0015075 +name: ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729] +subset: goslim_goa +subset: gosubset_prok +synonym: "ion transporter activity" EXACT [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0015076 +name: heavy metal ion transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of, within or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +is_obsolete: true +consider: GO:0046873 + +[Term] +id: GO:0015077 +name: monovalent inorganic cation transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "univalent inorganic cation transporter" EXACT [] +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0015078 +name: hydrogen ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "proton transporter" EXACT [] +xref: Reactome:1383 +is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity + +[Term] +id: GO:0015079 +name: potassium ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0022817 +def: "Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "potassium transporter" EXACT [] +is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015080 +name: silver ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai] +synonym: "silver transporter" EXACT [] +is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015081 +name: sodium ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0022816 +def: "Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "sodium transporter" EXACT [] +is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015082 +name: di-, tri-valent inorganic cation transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of inorganic cations with a valency of two or three from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0015083 +name: aluminum ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015084 +def: "Catalysis of the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "aluminium ion transporter activity" EXACT [] +synonym: "aluminium resistance permease activity" EXACT [] +synonym: "aluminum resistance permease activity" EXACT [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015085 +name: calcium ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:df] +subset: gosubset_prok +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015086 +name: cadmium ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:df] +subset: gosubset_prok +synonym: "zinc, cadmium uptake permease activity" NARROW [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015087 +name: cobalt ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:df] +subset: gosubset_prok +synonym: "cobalt, zinc uptake permease activity" NARROW [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015088 +name: copper uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in)." [TC:9.A.12.-.-] +is_a: GO:0005375 ! copper ion transmembrane transporter activity + +[Term] +id: GO:0015089 +name: high affinity copper ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu2+(out) = Cu2+(in)." [TC:9.A.11.1.1] +synonym: "high affinity copper transporter" EXACT [] +is_a: GO:0005375 ! copper ion transmembrane transporter activity + +[Term] +id: GO:0015090 +name: low affinity iron ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in)." [TC:9.A.9.1.1] +synonym: "low affinity iron transporter" EXACT [] +is_a: GO:0005381 ! iron ion transmembrane transporter activity + +[Term] +id: GO:0015091 +name: ferric iron transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005381 ! iron ion transmembrane transporter activity + +[Term] +id: GO:0015092 +name: high affinity ferric uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of Fe(III) from the outside of a cell to the inside of a cell across a membrane." [GOC:ai, TC:9.A.10.1.1] +is_a: GO:0015091 ! ferric iron transmembrane transporter activity + +[Term] +id: GO:0015093 +name: ferrous iron transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005381 ! iron ion transmembrane transporter activity + +[Term] +id: GO:0015094 +name: lead ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015095 +name: magnesium ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:df] +subset: gosubset_prok +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015096 +name: manganese resistance permease activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport] +comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition. +is_obsolete: true + +[Term] +id: GO:0015097 +name: mercury ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015098 +name: molybdate ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "molybdate transporter activity" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015099 +name: nickel ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nickel (Ni) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015100 +name: vanadium ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015101 +name: organic cation transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0008324 ! cation transmembrane transporter activity + +[Term] +id: GO:0015103 +name: inorganic anion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008509 ! anion transmembrane transporter activity + +[Term] +id: GO:0015104 +name: antimonite transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of antimonite from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015105 +name: arsenite transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of arsenite from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015106 +name: bicarbonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015107 +name: chlorate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of chlorate from one side of a membrane to the other. Chlorates are inorganic salts of chloric acid that contain the ClO3- ion." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015108 +name: chloride transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of chloride ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015109 +name: chromate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015110 +name: cyanate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015111 +name: iodide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of iodide ions from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015112 +name: nitrate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "nitrite/nitrate porter activity" NARROW [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015113 +name: nitrite transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nitrite (NO2(-)) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "nitrite/nitrate porter activity" NARROW [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015114 +name: phosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015115 +name: silicate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, http://cancerweb.ncl.ac.uk/] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015116 +name: sulfate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of sulfate ions (SO4 2-) from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "sulfate permease activity" RELATED [] +synonym: "sulphate transporter activity" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015117 +name: thiosulfate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of thiosulfate ions (S2O3 2-) from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "thiosulfate permease activity" RELATED [] +synonym: "thiosulphate transporter activity" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015118 +name: tellurite transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015119 +name: hexose phosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0015120 +name: phosphoglycerate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of phosphoglycerates from one side of the membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005342 ! organic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015121 +name: phosphoenolpyruvate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of phosphoenolpyruvate from one side of a membrane to the other. Phosphoenolpyruvate is the phosphate ester formed from the hydroxy group of the enol tautomer of pyruvate. It is a key intermediate in glycolysis and gluconeogenesis, and in the biosynthesis of aromatic amino acids." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015123 +name: acetate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of acetate from one side of the membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015124 +name: allantoate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of allantoate from one side of the membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015125 +name: bile acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015126 +name: canalicular bile acid transmembrane transporter activity +namespace: molecular_function +is_a: GO:0015125 ! bile acid transmembrane transporter activity + +[Term] +id: GO:0015127 +name: bilirubin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of bilirubin from one side of the membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015128 +name: gluconate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of gluconate from one side of the membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015129 +name: lactate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015130 +name: mevalonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of mevalonate from one side of the membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015131 +name: oxaloacetate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of the membrane to the other." [GOC:ai] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015132 +name: prostaglandin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai] +synonym: "prostaglandin/thromboxane transporter activity" BROAD [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015133 +name: uronic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of uronic acid from one side of the membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015134 +name: hexuronate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of hexuronates from one side of the membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015133 ! uronic acid transmembrane transporter activity + +[Term] +id: GO:0015135 +name: glucuronate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glucuronate from one side of the membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] +is_a: GO:0015134 ! hexuronate transmembrane transporter activity + +[Term] +id: GO:0015136 +name: sialic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of sialic acid from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0015137 +name: citrate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015138 +name: fumarate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of fumarate from one side of the membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015139 +name: alpha-ketoglutarate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of alpha-ketoglutarate from one side of the membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684] +subset: gosubset_prok +synonym: "2-oxoglutarate transporter" EXACT [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015140 +name: malate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015141 +name: succinate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015142 +name: tricarboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai] +subset: gosubset_prok +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015143 +name: urate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai] +synonym: "uric acid transmembrane transporter activity" EXACT [] +is_a: GO:0005342 ! organic acid transmembrane transporter activity + +[Term] +id: GO:0015144 +name: carbohydrate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of carbohydrate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "sugar transporter" NARROW [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0015145 +name: monosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of monosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0051119 ! sugar transmembrane transporter activity + +[Term] +id: GO:0015146 +name: pentose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a pentose sugar, a monosaccharide with 5 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0015147 +name: L-arabinose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-arabinose from one side of the membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0015148 +name: D-xylose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-xylose from one side of the membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015146 ! pentose transmembrane transporter activity + +[Term] +id: GO:0015149 +name: hexose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0015150 +name: fucose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of fucose from one side of the membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015151 +name: alpha-glucoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of alpha-glucosides from one side of the membrane to the other. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +is_a: GO:0042947 ! glucoside transmembrane transporter activity + +[Term] +id: GO:0015152 +name: glucose-6-phosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity + +[Term] +id: GO:0015153 +name: rhamnose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of rhamnose from one side of the membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015154 +name: disaccharide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of disaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0051119 ! sugar transmembrane transporter activity + +[Term] +id: GO:0015155 +name: lactose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019189 +def: "Catalysis of the transfer of lactose from one side of the membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "lactose permease activity" EXACT [] +synonym: "lactose/glucose efflux transporter activity" NARROW [] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0015156 +name: melibiose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of melibiose from one side of the membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0015157 +name: oligosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of oligosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "endosomal oligosaccharide transporter" NARROW [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0015158 +name: raffinose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of raffinose from one side of the membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "raffinose permease" RELATED [] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity + +[Term] +id: GO:0015159 +name: polysaccharide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of polysaccharides from one side of the membrane to the other. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0015160 +name: beta-glucan transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of beta-glucans from one side of the membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0015161 +name: capsular-polysaccharide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of capsular-polysaccharides from one side of the membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "capsule polysaccharide transporter activity" EXACT [] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0015162 +name: teichoic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of teichoic acid from one side of the membrane to the other. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0015163 +name: hexuronide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexuronide from one side of the membrane to the other. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0015164 +name: glucuronoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucuronosides from one side of the membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "glucuronide transporter activity" EXACT [] +is_a: GO:0015163 ! hexuronide transmembrane transporter activity + +[Term] +id: GO:0015165 +name: pyrimidine nucleotide sugar transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0015166 +name: polyol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sugar/polyol channel activity" NARROW [] +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0015167 +name: arabitol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an arabitol from one side of the membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "arabinitol transporter activity" EXACT [] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015168 +name: glycerol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015169 +name: glycerol-3-phosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glycerol-3-phosphate from one side of the membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015168 ! glycerol transmembrane transporter activity + +[Term] +id: GO:0015170 +name: propanediol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of propanediol from one side of the membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015171 +name: amino acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015359 +def: "Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "amino acid permease activity" EXACT [] +synonym: "amino acid transporter activity" BROAD [] +synonym: "amino acid/choline transmembrane transporter activity" NARROW [] +synonym: "general amino acid permease activity" RELATED [] +synonym: "hydroxy/aromatic amino acid permease activity" NARROW [] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015172 +name: acidic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "acidic amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015173 +name: aromatic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "aromatic amino acid transporter activity" BROAD [] +synonym: "hydroxy/aromatic amino acid permease activity" NARROW [] +synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015174 +name: basic amino acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005286 +def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "basic amino acid permease activity" EXACT [] +synonym: "basic amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015175 +name: neutral amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "neutral amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015176 +name: holin +namespace: molecular_function +def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0008565 +consider: GO:0019835 + +[Term] +id: GO:0015179 +name: L-amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the levorotatory isomer of amino acids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015180 +name: L-alanine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine, the levorotatory isomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "L-alanine transporter activity" BROAD [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0022858 ! alanine transmembrane transporter activity + +[Term] +id: GO:0015181 +name: arginine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005288 +def: "Catalysis of the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "arginine permease activity" EXACT [] +synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] +synonym: "L-arginine transporter activity" NARROW [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015182 +name: L-asparagine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the levorotatory isomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "asparagine/glutamine permease activity" NARROW [] +synonym: "L-asparagine transporter activity" BROAD [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015183 +name: L-aspartate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "glutamate/aspartate porter activity" NARROW [] +synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] +synonym: "L-aspartate transporter activity" BROAD [] +is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015184 +name: L-cystine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +synonym: "cystine/diaminopimelate porter activity" NARROW [] +synonym: "L-cystine transporter activity" BROAD [] +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015185 +name: L-gamma-aminobutyric acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-gamma-aminobutyric acid from one side of a membrane to the other. L-gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "4-aminobutanoate transporter activity" EXACT [] +synonym: "4-aminobutyrate transporter activity" EXACT [] +synonym: "betaine/GABA:sodium symporter activity" NARROW [] +synonym: "GABA transporter activity" EXACT [] +synonym: "L-gamma-aminobutyrate transporter activity" EXACT [] +synonym: "L-gamma-aminobutyric acid transporter activity" BROAD [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015186 +name: L-glutamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "asparagine/glutamine permease activity" NARROW [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015187 +name: glycine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "glycine transporter activity" BROAD [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0015188 +name: L-isoleucine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "isoleucine/valine:sodium symporter activity" NARROW [] +synonym: "L-isoleucine transporter activity" BROAD [] +synonym: "leucine/isoleucine/valine porter activity" NARROW [] +synonym: "leucine/valine/isoleucine permease activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015189 +name: L-lysine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005293 +def: "Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] +synonym: "L-lysine permease" RELATED [] +synonym: "lysine permease activity" RELATED [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015190 +name: L-leucine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-leucine transporter activity" BROAD [] +synonym: "leucine/isoleucine/valine porter activity" NARROW [] +synonym: "leucine/valine/isoleucine permease activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015191 +name: L-methionine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-methionine transporter activity" BROAD [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0043865 ! methionine transmembrane transporter activity + +[Term] +id: GO:0015192 +name: L-phenylalanine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-phenylalanine permease activity" EXACT [] +synonym: "L-phenylalanine transporter activity" BROAD [] +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015193 +name: L-proline transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005296 +def: "Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "L-proline permease activity" RELATED [] +synonym: "L-proline transporter activity" BROAD [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015194 +name: L-serine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015511 +def: "Catalysis of the transfer of L-serine from one side of a membrane to the other. L-serine is the levorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-serine permease activity" RELATED [] +synonym: "L-serine transporter activity" BROAD [] +synonym: "serine transporter activity" BROAD [] +synonym: "threonine/serine:sodium symporter activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0022889 ! serine transmembrane transporter activity + +[Term] +id: GO:0015195 +name: L-threonine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015512 +def: "Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-threonine permease activity" RELATED [] +synonym: "L-threonine transporter activity" BROAD [] +synonym: "threonine/serine:sodium symporter activity" NARROW [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015196 +name: L-tryptophan transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005299 +def: "Catalysis of the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-tryptophan permease activity" EXACT [] +synonym: "L-tryptophan transporter activity" BROAD [] +synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015197 +name: peptide transporter activity +namespace: molecular_function +alt_id: GO:0015637 +def: "Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "peptide uptake permease activity" RELATED [] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0015198 +name: oligopeptide transporter activity +namespace: molecular_function +def: "Enables the directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015197 ! peptide transporter activity + +[Term] +id: GO:0015199 +name: betaine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "betaine/GABA:sodium symporter activity" NARROW [] +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0015200 +name: methylammonium transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of methylammonium, CH3NH2, into, out of, within or between cells." [GOC:ai] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0015203 +name: polyamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "amine/amide/polyamine channel activity" NARROW [] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0015204 +name: urea transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015287 +def: "Enables the directed movement of urea cross a membrane into, out of, within or between cells. Urea is the water soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle. It is the main nitrogen-containing (urinary) excretion product in ureotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "urea transporter activity" BROAD [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0042887 ! amide transporter activity + +[Term] +id: GO:0015205 +name: nucleobase transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015392 +def: "Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity + +[Term] +id: GO:0015207 +name: adenine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] +xref: Reactome:21842 +is_a: GO:0005345 ! purine transmembrane transporter activity + +[Term] +id: GO:0015208 +name: guanine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators] +is_a: GO:0005345 ! purine transmembrane transporter activity + +[Term] +id: GO:0015209 +name: cytosine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0005350 ! pyrimidine transmembrane transporter activity + +[Term] +id: GO:0015210 +name: uracil transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators] +subset: gosubset_prok +synonym: "uracil/uridine permease activity" RELATED [] +is_a: GO:0005350 ! pyrimidine transmembrane transporter activity + +[Term] +id: GO:0015211 +name: purine nucleoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0015212 +name: cytidine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators] +is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity + +[Term] +id: GO:0015213 +name: uridine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators] +synonym: "uracil/uridine permease activity" NARROW [] +is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity + +[Term] +id: GO:0015214 +name: pyrimidine nucleoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0015215 +name: nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity + +[Term] +id: GO:0015216 +name: purine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0015217 +name: ADP transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity + +[Term] +id: GO:0015218 +name: pyrimidine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0015219 +name: DNA-protein complex transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of DNA-protein complexes from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity + +[Term] +id: GO:0015220 +name: choline transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005306 +def: "Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] +subset: gosubset_prok +synonym: "amino acid/choline transmembrane transporter activity" NARROW [] +synonym: "choline permease activity" EXACT [] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0015221 +name: lipopolysaccharide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of lipopolysaccharides from one side of the membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "LPS transmembrane transporter activity" EXACT [] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0015222 +name: serotonin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] +is_a: GO:0005326 ! neurotransmitter transporter activity +is_a: GO:0008504 ! monoamine transmembrane transporter activity + +[Term] +id: GO:0015223 +name: vitamin or cofactor transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of, within or between cells." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "vitamin/cofactor transporter activity" EXACT [] +is_obsolete: true +consider: GO:0051183 +consider: GO:0051184 + +[Term] +id: GO:0015224 +name: biopterin transporter activity +namespace: molecular_function +def: "Enables the directed movement of biopterin into, out of, within or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015225 +name: biotin transporter activity +namespace: molecular_function +def: "Enables the directed movement of biotin into, out of, within or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] +synonym: "vitamin B7 transporter activity" EXACT [] +synonym: "vitamin H transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015226 +name: carnitine transporter activity +namespace: molecular_function +def: "Enables the directed movement of carnitine into, out of, within or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin Bt transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015227 +name: acyl carnitine transporter activity +namespace: molecular_function +def: "Enables the directed movement of acyl carnitine into, out of, within or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "acylcarnitine transporter activity" EXACT [] +is_a: GO:0015226 ! carnitine transporter activity + +[Term] +id: GO:0015228 +name: coenzyme A transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of coenzyme A across a membrane into, out of, within or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] +synonym: "coenzyme A transporter activity" BROAD [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0051185 ! coenzyme transporter activity + +[Term] +id: GO:0015229 +name: L-ascorbic acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of L-ascorbate into, out of, within or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "L-ascorbate transporter activity" EXACT [] +synonym: "vitamin C transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0015230 +name: FAD transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of, within or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "FAD transporter activity" BROAD [] +synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT [] +synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015231 +name: 5-formyltetrahydrofolate transporter activity +namespace: molecular_function +def: "Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells." [GOC:ai] +is_a: GO:0008517 ! folic acid transporter activity + +[Term] +id: GO:0015232 +name: heme transporter activity +namespace: molecular_function +def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "haem transporter activity" EXACT [] +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015233 +name: pantothenate transporter activity +namespace: molecular_function +def: "Enables the directed movement of pantothenate into, out of, within or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "vitamin B5 transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015234 +name: thiamin transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015402 +def: "Catalysis of the transfer of thiamin from one side of the membrane to the other. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "thiamin permease activity" EXACT [] +synonym: "thiamine permease activity" EXACT [] +synonym: "thiamine transmembrane transporter activity" EXACT [] +synonym: "vitamin B1 transporter activity" EXACT [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0015235 +name: cobalamin transporter activity +namespace: molecular_function +def: "Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin B12 transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0015238 +name: drug transporter activity +namespace: molecular_function +def: "Enables the directed movement of a drug into, out of, within or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0015239 +name: multidrug transporter activity +namespace: molecular_function +def: "Enables the directed movement of drugs across a membrane into, out of, within or between cells." [GOC:ai, GOC:mah] +subset: gosubset_prok +is_a: GO:0015238 ! drug transporter activity +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015240 +name: amiloride transporter activity +namespace: molecular_function +def: "Enables the directed movement of amiloride of amiloride into, out of, within or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0015241 +name: aminotriazole transporter activity +namespace: molecular_function +def: "Enables the directed movement of aminotriazole into, out of, within or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0045118 ! azole transporter activity + +[Term] +id: GO:0015242 +name: benomyl transporter activity +namespace: molecular_function +def: "Enables the directed movement of benomyl into, out of, within or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0015238 ! drug transporter activity +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0015243 +name: cycloheximide transporter activity +namespace: molecular_function +def: "Enables the directed movement of cycloheximide into, out of, within or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042895 ! antibiotic transporter activity + +[Term] +id: GO:0015244 +name: fluconazole transporter activity +namespace: molecular_function +def: "Enables the directed movement of fluconazole into, out of, within or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0045118 ! azole transporter activity + +[Term] +id: GO:0015245 +name: fatty acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0015246 +name: fatty acyl transporter activity +namespace: molecular_function +def: "Enables the directed movement of a fatty acyl group into, out of, within or between cells. A fatty acyl group is any acyl group derived from a fatty acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "peroxisomal fatty acyl transporter" NARROW [] +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0015247 +name: aminophospholipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005548 ! phospholipid transporter activity + +[Term] +id: GO:0015248 +name: sterol transporter activity +namespace: molecular_function +def: "Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0015250 +name: water channel activity +namespace: molecular_function +def: "Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "aquaporin" NARROW [] +is_a: GO:0005372 ! water transporter activity +is_a: GO:0022838 ! substrate specific channel activity + +[Term] +id: GO:0015251 +name: ammonium channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0008519 ! ammonium transmembrane transporter activity + +[Term] +id: GO:0015252 +name: hydrogen ion channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0015253 +name: sugar/polyol channel activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents two molecular functions. +is_obsolete: true +consider: GO:0015166 +consider: GO:0051119 + +[Term] +id: GO:0015254 +name: glycerol channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015168 ! glycerol transmembrane transporter activity + +[Term] +id: GO:0015255 +name: propanediol channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] +is_a: GO:0015170 ! propanediol transmembrane transporter activity + +[Term] +id: GO:0015256 +name: monocarboxylate channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015257 +name: organic anion channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015258 +name: gluconate channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015259 +name: glutamate channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015260 +name: isethionate channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015261 +name: lactate channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015262 +name: taurine channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +is_obsolete: true + +[Term] +id: GO:0015263 +name: amine/amide/polyamine channel activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents three molecular functions. +is_obsolete: true +consider: GO:0005275 +consider: GO:0015203 +consider: GO:0042887 + +[Term] +id: GO:0015264 +name: methylammonium channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport] +is_a: GO:0015200 ! methylammonium transmembrane transporter activity + +[Term] +id: GO:0015265 +name: urea channel activity +namespace: molecular_function +def: "Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] +is_a: GO:0015204 ! urea transmembrane transporter activity +is_a: GO:0022838 ! substrate specific channel activity + +[Term] +id: GO:0015266 +name: protein channel activity +namespace: molecular_function +is_a: GO:0008320 ! protein transmembrane transporter activity +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0015267 +name: channel activity +namespace: molecular_function +alt_id: GO:0015249 +alt_id: GO:0015268 +def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] +subset: goslim_goa +subset: gosubset_prok +synonym: "alpha-type channel activity" RELATED [] +synonym: "channel-forming toxin activity" RELATED [] +synonym: "channel/pore class transporter activity" EXACT [] +synonym: "nonselective channel activity" EXACT [] +synonym: "pore activity" BROAD [] +synonym: "pore class transporter activity" RELATED [] +xref: TC:1 +is_a: GO:0022803 ! passive transmembrane transporter activity + +[Term] +id: GO:0015269 +name: calcium-activated potassium channel activity +namespace: molecular_function +def: "Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] +subset: gosubset_prok +is_a: GO:0005227 ! calcium activated cation channel activity +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0015270 +name: dihydropyridine-sensitive calcium channel activity +namespace: molecular_function +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0015271 +name: outward rectifier potassium channel activity +namespace: molecular_function +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0015272 +name: ATP-activated inward rectifier potassium channel activity +namespace: molecular_function +is_a: GO:0005242 ! inward rectifier potassium channel activity + +[Term] +id: GO:0015273 +name: G-protein enhanced inward rectifier potassium channel activity +namespace: molecular_function +synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT [] +synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT [] +is_a: GO:0005242 ! inward rectifier potassium channel activity + +[Term] +id: GO:0015274 +name: organellar voltage-gated chloride channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "organellar voltage gated chloride channel activity" EXACT [] +synonym: "organellar voltage-dependent chloride channel activity" EXACT [] +is_a: GO:0005247 ! voltage-gated chloride channel activity + +[Term] +id: GO:0015275 +name: stretch-activated, cation-selective, calcium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport] +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0008381 ! mechanically-gated ion channel activity + +[Term] +id: GO:0015276 +name: ligand-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "ionotropic neurotransmitter receptor" NARROW [] +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022834 ! ligand-gated channel activity + +[Term] +id: GO:0015277 +name: kainate selective glutamate receptor activity +namespace: molecular_function +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'inotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. +is_a: GO:0004970 ! ionotropic glutamate receptor activity + +[Term] +id: GO:0015278 +name: calcium-release channel activity +namespace: molecular_function +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0015279 +name: store-operated calcium channel activity +namespace: molecular_function +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0015280 +name: amiloride-sensitive sodium channel activity +namespace: molecular_function +synonym: "epithelial sodium channel" EXACT [] +is_a: GO:0005272 ! sodium channel activity +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0015282 +name: NADPH oxidase-associated cytochrome b558 hydrogen channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it describes a gene product rather than a function. +synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015283 +name: apoptogenic cytochrome c release channel activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it represents a gene product. +synonym: "Bcl-2" NARROW [] +is_obsolete: true + +[Term] +id: GO:0015284 +name: fructose uniporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] +is_a: GO:0005353 ! fructose transmembrane transporter activity +is_a: GO:0008516 ! hexose uniporter activity + +[Term] +id: GO:0015288 +name: porin activity +namespace: molecular_function +def: "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] +subset: gosubset_prok +synonym: "outer membrane exporter porin" NARROW [] +synonym: "porin" EXACT [] +is_a: GO:0022829 ! wide pore channel activity + +[Term] +id: GO:0015289 +name: pore-forming toxin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0005198 +consider: GO:0009405 +consider: GO:0046930 +consider: GO:0046931 +consider: GO:0050827 + +[Term] +id: GO:0015291 +name: secondary active transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015290 +def: "Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729, PMID:10839820] +subset: gosubset_prok +synonym: "active transporter" BROAD [] +synonym: "coupled carrier" EXACT [] +synonym: "electrochemical potential-driven transporter activity" EXACT [] +synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] +synonym: "heavy metal ion porter activity" NARROW [] +synonym: "nitrite/nitrate porter activity" NARROW [] +synonym: "porter activity" EXACT [] +synonym: "porters" EXACT [] +synonym: "secondary carrier-type facilitators" EXACT [] +xref: TC:2.A +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0015292 +name: uniporter activity +namespace: molecular_function +def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] +subset: gosubset_prok +synonym: "facilitated diffusion carrier" EXACT [] +synonym: "single-species transporter" EXACT [] +synonym: "uniport" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015293 +name: symporter activity +namespace: molecular_function +def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] +subset: gosubset_prok +synonym: "cotransporter" BROAD [] +synonym: "porter" BROAD [] +synonym: "symport" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015294 +name: solute:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015293 ! symporter activity + +[Term] +id: GO:0015295 +name: solute:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] +synonym: "high affinity metal ion uptake transporter activity" NARROW [] +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] +synonym: "low affinity metal ion uptake transporter activity" NARROW [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +synonym: "solute:proton symporter" EXACT [] +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015296 +name: anion:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] +subset: gosubset_prok +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015297 +name: antiporter activity +namespace: molecular_function +def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] +subset: gosubset_prok +synonym: "antiport" RELATED [] +synonym: "countertransporter" EXACT [] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] +synonym: "exchange transporter" EXACT [] +synonym: "exchanger" BROAD [] +synonym: "porter" BROAD [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015298 +name: solute:cation antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0015299 +name: solute:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] +subset: gosubset_prok +synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] +synonym: "solute:proton antiporter" EXACT [] +is_a: GO:0015298 ! solute:cation antiporter activity + +[Term] +id: GO:0015300 +name: solute:solute antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:ai] +subset: gosubset_prok +synonym: "solute:solute exchange" RELATED [] +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0015301 +name: anion:anion antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport] +subset: gosubset_prok +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0015303 +name: galactose, glucose uniporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6] +comment: This term was made obsolete because it represents two molecular functions. +is_obsolete: true +consider: GO:0015304 +consider: GO:0050782 + +[Term] +id: GO:0015304 +name: glucose uniporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6] +synonym: "galactose, glucose uniporter activity" NARROW [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008516 ! hexose uniporter activity + +[Term] +id: GO:0015305 +name: lactose, galactose:hydrogen symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9] +comment: This term was made obsolete because it represents two molecular functions. +synonym: "lactose,galactose:proton symporter" EXACT [] +is_obsolete: true +consider: GO:0015517 +consider: GO:0015528 + +[Term] +id: GO:0015306 +name: sialate:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10] +synonym: "cation/sialate symporter activity" EXACT [] +synonym: "cation:sialate symporter activity" EXACT [] +synonym: "sialate transporter activity" BROAD [] +synonym: "sialate/cation symporter activity" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015307 +name: drug:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-] +subset: gosubset_prok +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] +synonym: "drug:proton antiporter" EXACT [] +is_a: GO:0015238 ! drug transporter activity +is_a: GO:0015299 ! solute:hydrogen antiporter activity + +[Term] +id: GO:0015308 +name: amiloride:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1] +synonym: "amiloride:proton antiporter" EXACT [] +is_a: GO:0015307 ! drug:hydrogen antiporter activity + +[Term] +id: GO:0015309 +name: cycloheximide:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] +synonym: "cycloheximide:proton antiporter" EXACT [] +is_a: GO:0015307 ! drug:hydrogen antiporter activity + +[Term] +id: GO:0015310 +name: benomyl:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] +synonym: "benomyl:proton antiporter" EXACT [] +is_a: GO:0015307 ! drug:hydrogen antiporter activity + +[Term] +id: GO:0015311 +name: monoamine:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] +synonym: "monoamine:proton antiporter" EXACT [] +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015299 ! solute:hydrogen antiporter activity + +[Term] +id: GO:0015312 +name: polyamine:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] +synonym: "polyamine:proton antiporter" EXACT [] +is_a: GO:0015203 ! polyamine transmembrane transporter activity +is_a: GO:0015299 ! solute:hydrogen antiporter activity + +[Term] +id: GO:0015313 +name: fluconazole:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] +synonym: "fluconazole:proton antiporter" EXACT [] +is_a: GO:0045119 ! azole:hydrogen antiporter activity + +[Term] +id: GO:0015314 +name: aminotriazole:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] +synonym: "aminotriazole:proton antiporter" EXACT [] +is_a: GO:0045119 ! azole:hydrogen antiporter activity + +[Term] +id: GO:0015315 +name: organophosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-] +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0015316 +name: nitrite/nitrate porter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015112 +consider: GO:0015113 +consider: GO:0015291 + +[Term] +id: GO:0015317 +name: phosphate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] +synonym: "phosphate:proton symporter" EXACT [] +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015318 +name: inorganic solute uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an inorganic solute from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "inorganic uptake permease activity" EXACT [] +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0015319 +name: sodium:inorganic phosphate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6] +is_a: GO:0005436 ! sodium:phosphate symporter activity + +[Term] +id: GO:0015320 +name: phosphate carrier activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion)." [TC:2.A.29.4.1, UniProtKB:P12234] +is_a: GO:0015114 ! phosphate transmembrane transporter activity + +[Term] +id: GO:0015321 +name: sodium-dependent phosphate transmembrane transporter activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0015114 ! phosphate transmembrane transporter activity + +[Term] +id: GO:0015322 +name: secondary active oligopeptide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an oligopeptide or oligopeptides from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] +subset: gosubset_prok +synonym: "oligopeptide porter activity" RELATED [] +is_a: GO:0015198 ! oligopeptide transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015323 +name: type V protein secretor activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +is_obsolete: true + +[Term] +id: GO:0015324 +name: peptide-acetyl-CoA secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "peptide-acetyl-CoA transporter activity" RELATED [] +is_a: GO:0015197 ! peptide transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015325 +name: acetyl-CoA:CoA antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] +is_a: GO:0008521 ! acetyl-CoA transporter activity +is_a: GO:0015300 ! solute:solute antiporter activity +is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity + +[Term] +id: GO:0015326 +name: cationic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a positively charged amino acid from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0008324 ! cation transmembrane transporter activity + +[Term] +id: GO:0015327 +name: cystine:glutamate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity +is_a: GO:0005313 ! L-glutamate transmembrane transporter activity +is_a: GO:0015184 ! L-cystine transmembrane transporter activity +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0015328 +name: cystine secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "cystine porter activity" RELATED [] +synonym: "cystinosin" NARROW [] +synonym: "lysosomal cystine transporter" NARROW [] +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity +is_a: GO:0015184 ! L-cystine transmembrane transporter activity + +[Term] +id: GO:0015330 +name: high affinity glutamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the high affinity transfer of glutamine from one side of the membrane to the other." [GOC:mtg_transport] +synonym: "high affinity glutamine permease activity" RELATED [] +is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity +is_a: GO:0015186 ! L-glutamine transmembrane transporter activity + +[Term] +id: GO:0015331 +name: asparagine/glutamine permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015182 +consider: GO:0015186 +consider: GO:0022857 + +[Term] +id: GO:0015332 +name: leucine/valine/isoleucine permease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005304 +consider: GO:0015188 +consider: GO:0015190 +consider: GO:0022857 + +[Term] +id: GO:0015333 +name: peptide:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-] +subset: gosubset_prok +synonym: "peptide:proton symporter" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0022897 ! proton-dependent peptide secondary active transmembrane transporter activity + +[Term] +id: GO:0015334 +name: high affinity oligopeptide transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of oligopeptide from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport] +is_a: GO:0015198 ! oligopeptide transporter activity + +[Term] +id: GO:0015335 +name: heavy metal ion:hydrogen symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "heavy metal ion:proton symporter" EXACT [] +is_obsolete: true +consider: GO:0015295 +consider: GO:0046873 + +[Term] +id: GO:0015336 +name: high affinity metal ion uptake transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0015295 +consider: GO:0046873 + +[Term] +id: GO:0015337 +name: low affinity metal ion uptake transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0015295 +consider: GO:0046873 + +[Term] +id: GO:0015339 +name: cobalt, zinc uptake permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1] +comment: This term was made obsolete because it represents more than one molecular function. +is_obsolete: true +consider: GO:0005385 +consider: GO:0015087 +consider: GO:0015563 + +[Term] +id: GO:0015340 +name: zinc, cadmium uptake permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2] +comment: This term was made obsolete because it represents more than one molecular function. +is_obsolete: true +consider: GO:0005385 +consider: GO:0015086 +consider: GO:0015563 + +[Term] +id: GO:0015341 +name: zinc efflux active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] +synonym: "zinc efflux permease activity" BROAD [] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0005385 ! zinc ion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022883 ! zinc efflux transmembrane transporter activity + +[Term] +id: GO:0015342 +name: zinc, iron permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-] +comment: This term was made obsolete because it represents more than one molecular function. +is_obsolete: true +consider: GO:0005381 +consider: GO:0005385 +consider: GO:0015563 + +[Term] +id: GO:0015343 +name: siderophore-iron transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015236 +alt_id: GO:0015237 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-] +subset: gosubset_prok +synonym: "iron-siderophore transporter activity" EXACT [] +synonym: "siderochrome-iron transporter activity" NARROW [] +is_a: GO:0005381 ! iron ion transmembrane transporter activity +is_a: GO:0042927 ! siderophore transporter activity + +[Term] +id: GO:0015344 +name: siderophore-iron (ferrioxamine) uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1] +synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] +is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity + +[Term] +id: GO:0015345 +name: ferric enterobactin:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] +synonym: "ferric-enterobactin:proton symporter" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity + +[Term] +id: GO:0015346 +name: ferric triacetylfusarinine C:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] +synonym: "ferric triacetylfusarinine C:proton symporter" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity +is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity + +[Term] +id: GO:0015347 +name: sodium-independent organic anion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015348 +name: prostaglandin/thromboxane transporter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0008028 +consider: GO:0015132 + +[Term] +id: GO:0015349 +name: thyroid hormone transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015350 +name: methotrexate transporter activity +namespace: molecular_function +def: "Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0015351 +name: bilirubin secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] +synonym: "bilirubin porter activity" RELATED [] +synonym: "bilitranslocase" NARROW [] +is_a: GO:0015127 ! bilirubin transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015352 +name: secondary active sterol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of sterol from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] +synonym: "sterol porter activity" RELATED [] +is_a: GO:0015248 ! sterol transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015353 +name: multidrug endosomal transmembrane transporter activity +namespace: molecular_function +is_a: GO:0015239 ! multidrug transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015354 +name: polyspecific organic cation transmembrane transporter activity +namespace: molecular_function +is_a: GO:0008513 ! secondary active organic cation transmembrane transporter activity + +[Term] +id: GO:0015355 +name: secondary active monocarboxylate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] +synonym: "monocarboxylate porter activity" RELATED [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015356 +name: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015129 +consider: GO:0015130 +consider: GO:0015562 +consider: GO:0015563 +consider: GO:0050833 + +[Term] +id: GO:0015358 +name: amino acid/choline transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015171 +consider: GO:0015220 + +[Term] +id: GO:0015360 +name: acetate:hydrogen symporter activity +namespace: molecular_function +alt_id: GO:0015357 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] +synonym: "acetate:proton symporter" EXACT [] +synonym: "hydrogen:acetate symporter activity" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0043893 ! acetate:cation symporter activity + +[Term] +id: GO:0015361 +name: low affinity sodium:dicarboxylate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] +synonym: "low affinity sodium:dicarboxylate cotransporter activity" EXACT [] +is_a: GO:0017153 ! sodium:dicarboxylate symporter activity + +[Term] +id: GO:0015362 +name: high affinity sodium:dicarboxylate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] +synonym: "high affinity sodium:dicarboxylate cotransporter activity" EXACT [] +is_a: GO:0017153 ! sodium:dicarboxylate symporter activity + +[Term] +id: GO:0015363 +name: dicarboxylate (succinate/fumarate/malate) antiporter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005310 +consider: GO:0015138 +consider: GO:0015140 +consider: GO:0015141 +consider: GO:0015297 + +[Term] +id: GO:0015364 +name: dicarboxylate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3] +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0015366 +name: malate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1] +synonym: "malate:proton symporter" EXACT [] +is_a: GO:0015140 ! malate transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015367 +name: oxoglutarate:malate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] +is_a: GO:0015300 ! solute:solute antiporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0015368 +name: calcium:cation antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] +subset: gosubset_prok +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0015369 +name: calcium:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-] +subset: gosubset_prok +synonym: "calcium:proton antiporter" EXACT [] +is_a: GO:0015368 ! calcium:cation antiporter activity +is_a: GO:0051139 ! metal ion:hydrogen antiporter activity + +[Term] +id: GO:0015370 +name: solute:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015371 +name: galactose:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015372 +name: glutamate/aspartate:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005283 +consider: GO:0005313 +consider: GO:0015183 + +[Term] +id: GO:0015373 +name: monovalent anion:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-] +is_a: GO:0015296 ! anion:cation symporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015374 +name: neutral, cationic amino acid:sodium:chloride symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/cationic amino acid(out) + Na+(out) + Cl-(out) = neutral/cationic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0015375 +name: glycine:sodium symporter activity +namespace: molecular_function +alt_id: GO:0015656 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity +is_a: GO:0015187 ! glycine transmembrane transporter activity + +[Term] +id: GO:0015376 +name: betaine/GABA:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005332 +consider: GO:0015185 +consider: GO:0015199 +consider: GO:0015370 + +[Term] +id: GO:0015377 +name: cation:chloride symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] +synonym: "cation:chloride cotransporter activity" EXACT [] +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015378 +name: sodium:chloride symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] +is_a: GO:0015377 ! cation:chloride symporter activity + +[Term] +id: GO:0015379 +name: potassium:chloride symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-] +is_a: GO:0015377 ! cation:chloride symporter activity + +[Term] +id: GO:0015380 +name: anion exchanger activity +namespace: molecular_function +alt_id: GO:0015384 +synonym: "bicarbonate:chloride antiporter" NARROW [] +is_a: GO:0015106 ! bicarbonate transmembrane transporter activity +is_a: GO:0015108 ! chloride transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0015381 +name: high affinity sulfate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the secondary active high affinity transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity sulfate permease activity" RELATED [] +synonym: "high affinity sulphate permease activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity + +[Term] +id: GO:0015382 +name: sodium:sulfate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] +synonym: "sodium:sulfate cotransporter activity" EXACT [] +synonym: "sodium:sulphate symporter activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015383 +name: sulfate:bicarbonate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] +synonym: "sulphate:bicarbonate antiporter activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity +is_a: GO:0015106 ! bicarbonate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0015385 +name: sodium:hydrogen antiporter activity +namespace: molecular_function +alt_id: GO:0015502 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] +subset: gosubset_prok +synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] +synonym: "pH-dependent sodium:proton antiporter" NARROW [] +synonym: "sodium/hydrogen antiporter" EXACT [] +synonym: "sodium:hydrogen exchange activity" EXACT [] +synonym: "sodium:hydrogen exchanger" EXACT [] +synonym: "sodium:proton antiporter" EXACT [] +is_a: GO:0005451 ! monovalent cation:proton antiporter activity + +[Term] +id: GO:0015386 +name: potassium:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-] +subset: gosubset_prok +synonym: "potassium:proton antiporter" EXACT [] +is_a: GO:0005451 ! monovalent cation:proton antiporter activity +is_a: GO:0022821 ! potassium ion antiporter activity + +[Term] +id: GO:0015387 +name: potassium:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-] +synonym: "potassium:proton symporter" EXACT [] +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0022820 ! potassium ion symporter activity + +[Term] +id: GO:0015388 +name: potassium uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of potassium from the outside of a cell to the inside of the cell across a membrane: K+(out) + energy = K+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.72.2.-] +synonym: "potassium uptake permease activity" EXACT [] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0015389 +name: pyrimidine- and adenine-specific:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3] +is_a: GO:0005345 ! purine transmembrane transporter activity +is_a: GO:0005350 ! pyrimidine transmembrane transporter activity +is_a: GO:0005415 ! nucleoside:sodium symporter activity + +[Term] +id: GO:0015390 +name: purine-specific nucleoside:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] +is_a: GO:0005415 ! nucleoside:sodium symporter activity + +[Term] +id: GO:0015391 +name: nucleobase:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015205 ! nucleobase transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015393 +name: uracil/uridine permease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015210 +consider: GO:0015213 +consider: GO:0022857 + +[Term] +id: GO:0015394 +name: uridine:hydrogen ion symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport] +synonym: "nucleoside (uridine) permease activity" RELATED [] +is_a: GO:0005350 ! pyrimidine transmembrane transporter activity +is_a: GO:0015213 ! uridine transmembrane transporter activity +is_a: GO:0015391 ! nucleobase:cation symporter activity +is_a: GO:0015506 ! nucleoside:hydrogen symporter activity + +[Term] +id: GO:0015395 +name: nucleoside transmembrane transporter activity, down a concentration gradient +namespace: molecular_function +def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811] +synonym: "equilibrative nucleoside transporter" EXACT [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015396 +name: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity +namespace: molecular_function +is_a: GO:0015395 ! nucleoside transmembrane transporter activity, down a concentration gradient + +[Term] +id: GO:0015397 +name: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity +namespace: molecular_function +is_a: GO:0015395 ! nucleoside transmembrane transporter activity, down a concentration gradient + +[Term] +id: GO:0015398 +name: high affinity secondary active ammonium transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +is_a: GO:0008519 ! ammonium transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015399 +name: primary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] +subset: gosubset_prok +synonym: "primary active transporter" RELATED [] +xref: TC:3 +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0015400 +name: low affinity secondary active ammonium transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] +synonym: "low affinity ammonium transmembrane transporter activity" RELATED [] +is_a: GO:0008519 ! ammonium transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015401 +name: urea:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] +synonym: "urea active transmembrane transporter activity" EXACT [] +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015403 +name: thiamin uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of thiamin from the outside of a cell to the inside across a membrane." [GOC:mtg_transport] +synonym: "thiamine uptake transporter activity" EXACT [] +is_a: GO:0015234 ! thiamin transmembrane transporter activity +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0015404 +name: ion-gradient-driven energizer activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015405 +name: P-P-bond-hydrolysis-driven transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-] +subset: gosubset_prok +synonym: "P-P-bond-hydrolysis-driven transporters" EXACT [] +xref: TC:3.A +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015406 +name: ABC-type uptake permease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0015407 +name: monosaccharide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17] +synonym: "monosaccharide ABC transporter" NARROW [] +synonym: "monosaccharide-importing ATPase activity" NARROW [] +xref: EC:3.6.3.17 +xref: MetaCyc:3.6.3.17-RXN +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +is_a: GO:0015608 ! carbohydrate-importing ATPase activity + +[Term] +id: GO:0015408 +name: ferric-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (ferric-ion-transporting)" EXACT [EC:3.6.3.30] +synonym: "Fe3+-transporting ATPase activity" EXACT [EC:3.6.3.30] +synonym: "ferric ABC transporter" NARROW [] +synonym: "ferric transporting ATPase activity" EXACT [] +xref: EC:3.6.3.30 +xref: MetaCyc:3.6.3.30-RXN +is_a: GO:0015091 ! ferric iron transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0015410 +name: manganese-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ABC-type manganese permease complex" RELATED [EC:3.6.3.35] +synonym: "ATP phosphohydrolase (manganese-importing)" EXACT [EC:3.6.3.35] +synonym: "manganese ABC transporter" NARROW [] +synonym: "manganese transporting ATPase activity" EXACT [] +xref: EC:3.6.3.35 +xref: MetaCyc:3.6.3.35-RXN +is_a: GO:0005384 ! manganese ion transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0015411 +name: taurine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:3.6.3.36] +synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT [] +synonym: "taurine ABC transporter" NARROW [] +xref: EC:3.6.3.36 +xref: MetaCyc:3.6.3.36-RXN +is_a: GO:0005368 ! taurine transmembrane transporter activity +is_a: GO:0015424 ! amino acid-transporting ATPase activity + +[Term] +id: GO:0015412 +name: molybdate transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:3.6.3.29] +synonym: "molybdate ABC transporter" NARROW [] +synonym: "molybdate porter activity" EXACT [] +synonym: "molybdate transporting ATPase activity" EXACT [] +synonym: "molybdate-transporting ATPase activity" EXACT [EC:3.6.3.29] +xref: EC:3.6.3.29 +xref: MetaCyc:3.6.3.29-RXN +is_a: GO:0015098 ! molybdate ion transmembrane transporter activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0015413 +name: nickel-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:3.6.3.24] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:3.6.3.24] +synonym: "nickel ABC transporter" NARROW [] +synonym: "nickel porter activity" EXACT [] +synonym: "nickel transporting ATPase activity" EXACT [] +xref: EC:3.6.3.24 +xref: MetaCyc:3.6.3.24-RXN +is_a: GO:0015099 ! nickel ion transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0015414 +name: nitrate transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:3.6.3.26] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:3.6.3.26] +synonym: "nitrate ABC transporter" NARROW [] +synonym: "nitrate transporting ATPase activity" EXACT [] +synonym: "nitrate-transporting ATPase activity" EXACT [EC:3.6.3.26] +xref: EC:3.6.3.26 +xref: MetaCyc:3.6.3.26-RXN +is_a: GO:0015112 ! nitrate transmembrane transporter activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0015415 +name: phosphate transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:3.6.3.27] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ABC phosphate transporter activity" NARROW [EC:3.6.3.27] +synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:3.6.3.27] +synonym: "phosphate ABC transporter" NARROW [] +synonym: "phosphate porter activity" EXACT [] +synonym: "phosphate transporting ATPase activity" EXACT [] +synonym: "phosphate-transporting ATPase activity" EXACT [EC:3.6.3.27] +xref: EC:3.6.3.27 +xref: MetaCyc:3.6.3.27-RXN +is_a: GO:0015114 ! phosphate transmembrane transporter activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0015416 +name: phosphonate transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [EC:3.6.3.28] +synonym: "phosphonate ABC transporter" NARROW [] +synonym: "phosphonate transporting ATPase activity" EXACT [] +synonym: "phosphonate-transporting ATPase activity" EXACT [EC:3.6.3.28] +xref: EC:3.6.3.28 +xref: MetaCyc:3.6.3.28-RXN +is_a: GO:0015604 ! phosphonate transmembrane transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0015417 +name: polyamine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (polyamine-importing) activity" EXACT [EC:3.6.3.31] +synonym: "polyamine ABC transporter" NARROW [] +synonym: "polyamine porter activity" EXACT [] +synonym: "polyamine-importing ATPase activity" NARROW [] +xref: EC:3.6.3.31 +is_a: GO:0015203 ! polyamine transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015418 +name: quaternary-ammonium-compound-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (quaternary-amine-importing) activity" EXACT [EC:3.6.3.32] +synonym: "glycine betaine/proline porter activity" RELATED [] +synonym: "quaternary amine uptake transporter activity" EXACT [] +synonym: "quaternary-amine-transporting ATPase activity" EXACT [] +synonym: "quaternary-ammonium-compound ABC transporter" NARROW [] +xref: EC:3.6.3.32 +xref: MetaCyc:3.6.3.32-RXN +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015419 +name: sulfate transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:3.6.3.25] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:3.6.3.25] +synonym: "sulfate ABC transporter" NARROW [] +synonym: "sulfate transporting ATPase activity" EXACT [] +synonym: "sulfate-transporting ATPase activity" EXACT [EC:3.6.3.25] +synonym: "sulfate/thiosulfate porter activity" EXACT [] +synonym: "sulphate transporting ATPase activity" EXACT [] +synonym: "sulphate-transporting ATPase activity" EXACT [] +xref: EC:3.6.3.25 +xref: MetaCyc:3.6.3.25-RXN +is_a: GO:0015116 ! sulfate transmembrane transporter activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0015420 +name: cobalamin-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + cobalamin(out) = ADP + phosphate + cobalamin(in). Cobalamin = vitamin B12." [EC:3.6.3.33] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (vitamin B12-importing)" EXACT [EC:3.6.3.33] +synonym: "cobalamin ABC transporter" NARROW [] +synonym: "cobalamin porter activity" EXACT [] +synonym: "vitamin B12 porter activity" EXACT [] +synonym: "vitamin B12-transporting ATPase activity" EXACT [] +xref: EC:3.6.3.33 +xref: MetaCyc:3.6.3.33-RXN +is_a: GO:0015235 ! cobalamin transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015421 +name: oligopeptide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:3.6.3.23] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (oligopeptide-importing)" EXACT [EC:3.6.3.23] +synonym: "oligopeptide ABC transporter" NARROW [] +synonym: "oligopeptide permease activity" RELATED [EC:3.6.3.23] +xref: EC:3.6.3.23 +xref: MetaCyc:3.6.3.23-RXN +is_a: GO:0015198 ! oligopeptide transporter activity +is_a: GO:0015440 ! peptide-transporting ATPase activity + +[Term] +id: GO:0015422 +name: oligosaccharide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:3.6.3.18] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (disaccharide-importing)" EXACT [EC:3.6.3.18] +synonym: "oligosaccharide ABC transporter" NARROW [] +xref: EC:3.6.3.18 +xref: MetaCyc:3.6.3.18-RXN +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015423 +name: maltose-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:3.6.3.19] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (maltose-importing)" EXACT [EC:3.6.3.19] +synonym: "maltose ABC transporter" NARROW [] +xref: EC:3.6.3.19 +xref: MetaCyc:3.6.3.19-RXN +is_a: GO:0005363 ! maltose transmembrane transporter activity +is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity + +[Term] +id: GO:0015424 +name: amino acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "amino acid ABC transporter" NARROW [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:0031263 ! amine-transporting ATPase activity + +[Term] +id: GO:0015425 +name: nonpolar-amino acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (nonpolar-amino-acid-transporting) activity" EXACT [EC:3.6.3.22] +synonym: "leucine/isoleucine/valine porter activity" RELATED [] +synonym: "nonpolar amino acid-transporting ATPase activity" EXACT [] +synonym: "nonpolar-amino acid ABC transporter" NARROW [] +synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT [] +xref: EC:3.6.3.22 +xref: MetaCyc:3.6.3.22-RXN +is_a: GO:0015424 ! amino acid-transporting ATPase activity + +[Term] +id: GO:0015426 +name: polar-amino acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (polar-amino-acid-importing) activity" EXACT [EC:3.6.3.21] +synonym: "cystine/diaminopimelate porter activity" RELATED [] +synonym: "glutamate/aspartate porter activity" RELATED [] +synonym: "histidine permease activity" NARROW [EC:3.6.3.21] +synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] +synonym: "polar amino acid uptake transporter activity" EXACT [] +synonym: "polar amino acid-importing ATPase activity" EXACT [] +synonym: "polar-amino acid ABC transporter" NARROW [] +synonym: "polar-amino acid-importing ATPase activity" EXACT [] +synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:3.6.3.21] +xref: EC:3.6.3.21 +xref: MetaCyc:3.6.3.21-RXN +is_a: GO:0015424 ! amino acid-transporting ATPase activity + +[Term] +id: GO:0015427 +name: ABC-type efflux porter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0015428 +name: type I protein secretor activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +is_obsolete: true + +[Term] +id: GO:0015429 +name: peroxisomal fatty acyl transporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product and it contains both component and function information. +is_obsolete: true +consider: GO:0005777 +consider: GO:0015246 + +[Term] +id: GO:0015430 +name: glycerol-3-phosphate-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:3.6.3.20] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (glycerol-3-phosphate-importing)" EXACT [EC:3.6.3.20] +synonym: "glycerol-3-phosphate ABC transporter" NARROW [] +xref: EC:3.6.3.20 +xref: MetaCyc:3.6.3.20-RXN +is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015431 +name: glutathione S-conjugate-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) = ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT [] +synonym: "conjugate transporter activity" BROAD [] +synonym: "GS-X pump" EXACT [] +synonym: "MRP1/GS-X pump" EXACT [] +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015432 +name: bile acid-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O = bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "bile acid porter activity" NARROW [] +is_a: GO:0015125 ! bile acid transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015433 +name: peptide antigen-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "major histocompatibility peptide transporter activity" EXACT [] +synonym: "peptide antigen ABC transporter" NARROW [] +synonym: "peptide antigen transporter activity" BROAD [] +is_a: GO:0015440 ! peptide-transporting ATPase activity + +[Term] +id: GO:0015434 +name: cadmium-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:3.6.3.46] +subset: gosubset_prok +synonym: "ATP phosphohydrolase (heavy-metal-exporting)" EXACT [EC:3.6.3.46] +synonym: "cadmium ABC transporter" NARROW [] +synonym: "yeast cadmium factor" RELATED [EC:3.6.3.46] +xref: EC:3.6.3.46 +is_a: GO:0015086 ! cadmium ion transmembrane transporter activity + +[Term] +id: GO:0015435 +name: ABC-type efflux permease activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0015436 +name: capsular-polysaccharide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:3.6.3.38] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:3.6.3.38] +synonym: "capsular-polysaccharide ABC transporter" NARROW [] +xref: EC:3.6.3.38 +xref: MetaCyc:3.6.3.38-RXN +is_a: GO:0015161 ! capsular-polysaccharide transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015437 +name: lipopolysaccharide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out)." [EC:3.6.3.39] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (lipopolysaccharide-exporting)" EXACT [EC:3.6.3.39] +synonym: "lipopolysaccharide ABC transporter" NARROW [] +synonym: "LPS-transporting ATPase activity" EXACT [] +xref: EC:3.6.3.39 +xref: MetaCyc:3.6.3.39-RXN +is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015438 +name: teichoic-acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (teichoic-acid-exporting)" EXACT [EC:3.6.3.40] +synonym: "teichoic-acid ABC transporter" NARROW [] +xref: EC:3.6.3.40 +xref: MetaCyc:3.6.3.40-RXN +is_a: GO:0015162 ! teichoic acid transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015439 +name: heme-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (heme-exporting)" EXACT [EC:3.6.3.41] +synonym: "haem-transporting ATPase activity" EXACT [] +synonym: "heme ABC transporter" NARROW [] +xref: EC:3.6.3.41 +xref: MetaCyc:3.6.3.41-RXN +is_a: GO:0015232 ! heme transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015440 +name: peptide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:3.6.3.43] +synonym: "peptide ABC transporter" NARROW [] +xref: EC:3.6.3.43 +xref: MetaCyc:3.6.3.43-RXN +is_a: GO:0015197 ! peptide transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015441 +name: beta-glucan-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:3.6.3.42] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (beta-glucan-exporting)" EXACT [EC:3.6.3.42] +synonym: "beta-glucan ABC transporter" NARROW [] +xref: EC:3.6.3.42 +xref: MetaCyc:3.6.3.42-RXN +is_a: GO:0015160 ! beta-glucan transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015442 +name: hydrogen-/sodium-translocating ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-] +comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification. +synonym: "proton-/sodium-translocating ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0008553 +consider: GO:0008554 + +[Term] +id: GO:0015443 +name: sodium-transporting two-sector ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15] +comment: This term was made obsolete because it refers to a bifunctional gene product. +is_obsolete: true +consider: GO:0046932 +consider: GO:0046962 + +[Term] +id: GO:0015444 +name: magnesium-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)." [EC:3.6.3.2] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:3.6.3.2] +synonym: "magnesium importing ATPase activity" EXACT [] +synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:3.6.3.2] +synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:3.6.3.2] +synonym: "Mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] +synonym: "mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] +xref: EC:3.6.3.2 +xref: MetaCyc:3.6.3.2-RXN +is_a: GO:0015095 ! magnesium ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0015445 +name: silver-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)." [EC:3.6.3.53] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "Ag+-exporting ATPase activity" EXACT [EC:3.6.3.53] +synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:3.6.3.53] +synonym: "silver exporting ATPase activity" EXACT [] +xref: EC:3.6.3.53 +xref: MetaCyc:3.6.3.53-RXN +is_a: GO:0015080 ! silver ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0015446 +name: arsenite transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16] +synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16] +synonym: "arsenical resistance efflux pump" EXACT [] +synonym: "arsenite ABC transporter" NARROW [] +synonym: "arsenite transporting ATPase activity" EXACT [] +synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16] +synonym: "arsenite-transporting ATPase activity" EXACT [EC:3.6.3.16] +synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:3.6.3.16] +xref: EC:3.6.3.16 +xref: MetaCyc:3.6.3.16-RXN +is_a: GO:0008490 ! arsenite secondary active transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0015447 +name: type II protein secretor activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +is_obsolete: true + +[Term] +id: GO:0015448 +name: type III protein (virulence-related) secretor activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +is_obsolete: true + +[Term] +id: GO:0015449 +name: type IV protein (DNA-protein) secretor activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +is_obsolete: true + +[Term] +id: GO:0015450 +name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity +namespace: molecular_function +def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "protein translocase activity" EXACT [] +is_a: GO:0008320 ! protein transmembrane transporter activity +is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity +is_a: GO:0022884 ! macromolecule transmembrane transporter activity + +[Term] +id: GO:0015451 +name: decarboxylation-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-] +subset: gosubset_prok +synonym: "Decarboxylation-driven transporters" RELATED [] +xref: TC:3.B +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015452 +name: methyl transfer-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] +synonym: "Methyltransfer-driven transporters" EXACT [] +xref: TC:3.C +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015453 +name: oxidoreduction-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] +subset: gosubset_prok +synonym: "Oxidoreduction-driven transporters" EXACT [] +xref: TC:3.D +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015454 +name: light-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-] +synonym: "Light absorption-driven transporters" EXACT [] +synonym: "light-driven pumps" EXACT [] +xref: TC:3.E +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015457 +name: auxiliary transport protein activity +namespace: molecular_function +def: "Facilitates transport across one or more biological membranes but do not themselves participate directly in transport. These proteins always function in conjunction with one or more established transport systems. They may provide a function connected with energy coupling to transport, play a structural role in complex formation, serve a biogenic or stability function or function in regulation." [TC:8.A.-.-.-] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0015458 +name: low voltage-gated potassium channel auxiliary protein activity +namespace: molecular_function +synonym: "low voltage-dependent potassium channel auxiliary protein activity" EXACT [] +is_a: GO:0015457 ! auxiliary transport protein activity + +[Term] +id: GO:0015459 +name: potassium channel regulator activity +namespace: molecular_function +is_a: GO:0016247 ! channel regulator activity + +[Term] +id: GO:0015460 +name: transport accessory protein activity +namespace: molecular_function +is_a: GO:0015457 ! auxiliary transport protein activity + +[Term] +id: GO:0015461 +name: endosomal oligosaccharide transporter +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0005768 +consider: GO:0015157 + +[Term] +id: GO:0015462 +name: protein-transmembrane transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "pilin/fimbrilin exporter activity" NARROW [] +synonym: "protein ABC transporter" NARROW [] +synonym: "protein-transporting ATPase activity" EXACT [] +is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015464 +name: acetylcholine receptor activity +namespace: molecular_function +def: "Combining with acetylcholine to initiate a change in cell activity." [GOC:jl] +is_a: GO:0004888 ! transmembrane receptor activity +is_a: GO:0030594 ! neurotransmitter receptor activity +is_a: GO:0042166 ! acetylcholine binding + +[Term] +id: GO:0015465 +name: lysin activity +namespace: molecular_function +def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015466 +name: autolysin activity +namespace: molecular_function +def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015467 +name: G-protein activated inward rectifier potassium channel activity +namespace: molecular_function +synonym: "G protein activated inward rectifier potassium channel activity" EXACT [] +synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT [] +is_a: GO:0005242 ! inward rectifier potassium channel activity + +[Term] +id: GO:0015468 +name: colicin +namespace: molecular_function +def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005198 +consider: GO:0009405 +consider: GO:0019835 +consider: GO:0046930 +consider: GO:0046931 +consider: GO:0050827 + +[Term] +id: GO:0015469 +name: channel-forming toxin activity +namespace: molecular_function +def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0009405 +consider: GO:0015267 +consider: GO:0046930 +consider: GO:0046931 +consider: GO:0050827 + +[Term] +id: GO:0015470 +name: bacteriocin activity +namespace: molecular_function +def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005102 +consider: GO:0019835 + +[Term] +id: GO:0015471 +name: nucleoside-specific channel forming porin activity +namespace: molecular_function +def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015472 +name: fimbrium-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046] +comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function. +is_obsolete: true +consider: GO:0009297 +consider: GO:0030674 +consider: GO:0051082 + +[Term] +id: GO:0015473 +name: fimbrial usher porin activity +namespace: molecular_function +def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015474 +name: autotransporter activity +namespace: molecular_function +def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] +subset: gosubset_prok +is_a: GO:0008565 ! protein transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015475 +name: adhesin autotransporter activity +namespace: molecular_function +def: "Catalysis of the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015474 ! autotransporter activity + +[Term] +id: GO:0015476 +name: hemaglutinin autotransporter activity +namespace: molecular_function +def: "Catalysis of the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015474 ! autotransporter activity + +[Term] +id: GO:0015477 +name: receptor porin activity +namespace: molecular_function +def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-] +comment: This term was made obsolete because it combines two functions that are not linked. +is_obsolete: true + +[Term] +id: GO:0015478 +name: oligosaccharide transporting porin activity +namespace: molecular_function +def: "Catalysis of the transfer of oligosaccharide, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +synonym: "raffinose porin" NARROW [] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015479 +name: outer membrane exporter porin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0009279 +consider: GO:0015288 + +[Term] +id: GO:0015480 +name: secretin (sensu Bacteria) +namespace: molecular_function +def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0008565 +consider: GO:0045203 + +[Term] +id: GO:0015481 +name: maltose transporting porin activity +namespace: molecular_function +def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +subset: gosubset_prok +synonym: "maltoporin" EXACT [] +is_a: GO:0005363 ! maltose transmembrane transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015482 +name: voltage-gated anion channel porin activity +namespace: molecular_function +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity. +synonym: "voltage-dependent anion channel porin activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015483 +name: long-chain fatty acid transporting porin activity +namespace: molecular_function +def: "Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids have a chain length of greater than 12 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +is_a: GO:0005324 ! long-chain fatty acid transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015484 +name: hemolysin activity +namespace: molecular_function +def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0019836 + +[Term] +id: GO:0015485 +name: cholesterol binding +namespace: molecular_function +def: "Interacting selectively with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0032934 ! sterol binding + +[Term] +id: GO:0015486 +name: glycoside-pentoside-hexuronide:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] +is_a: GO:0005402 ! cation:sugar symporter activity + +[Term] +id: GO:0015487 +name: melibiose:monovalent cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1] +subset: gosubset_prok +synonym: "melibiose permease activity" RELATED [] +is_a: GO:0015156 ! melibiose transmembrane transporter activity +is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity + +[Term] +id: GO:0015488 +name: glucuronide:monovalent cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] +synonym: "glucuronoside permease activity" RELATED [] +is_a: GO:0015164 ! glucuronoside transmembrane transporter activity +is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity + +[Term] +id: GO:0015489 +name: putrescine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015203 ! polyamine transmembrane transporter activity + +[Term] +id: GO:0015490 +name: cadaverine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cadaverine, 1,5-pentanediamine, from one side of the membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0015491 +name: cation:cation antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015298 ! solute:cation antiporter activity + +[Term] +id: GO:0015492 +name: phenylalanine:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] +synonym: "phenylalanine:proton symporter" EXACT [] +is_a: GO:0015192 ! L-phenylalanine transmembrane transporter activity +is_a: GO:0015494 ! aromatic amino acid:hydrogen symporter activity + +[Term] +id: GO:0015493 +name: lysine:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] +synonym: "lysine:proton symporter" EXACT [] +is_a: GO:0005280 ! hydrogen:amino acid symporter activity +is_a: GO:0015189 ! L-lysine transmembrane transporter activity + +[Term] +id: GO:0015494 +name: aromatic amino acid:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] +synonym: "aromatic amino acid:proton symporter" EXACT [] +is_a: GO:0005280 ! hydrogen:amino acid symporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity + +[Term] +id: GO:0015495 +name: gamma-aminobutyric acid:hydrogen symporter activity +namespace: molecular_function +alt_id: GO:0005331 +alt_id: GO:0015329 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2] +comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. +synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT [] +synonym: "4-aminobutanoate:proton symporter activity" EXACT [] +synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT [] +synonym: "4-aminobutyrate:proton symporter activity" EXACT [] +synonym: "GABA:hydrogen symporter activity" EXACT [] +synonym: "GABA:proton symporter activity" EXACT [] +synonym: "gamma-aminobutyric acid permease activity" EXACT [] +synonym: "gamma-aminobutyric acid:proton symporter" EXACT [] +is_a: GO:0005280 ! hydrogen:amino acid symporter activity +is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015496 +name: putrescine:ornithine antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1] +subset: gosubset_prok +synonym: "putrescine-ornithine antiporter activity" EXACT [] +synonym: "putrescine/ornithine antiporter activity" EXACT [] +synonym: "putrescine:hydrogen symporter" EXACT [] +is_a: GO:0000064 ! L-ornithine transmembrane transporter activity +is_a: GO:0015300 ! solute:solute antiporter activity +is_a: GO:0015489 ! putrescine transmembrane transporter activity + +[Term] +id: GO:0015497 +name: cadaverine:lysine antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cadaverine(out) + lysine(in) = cadaverine(in) + lysine(out)." [TC:2.A.3.2.2] +subset: gosubset_prok +is_a: GO:0015189 ! L-lysine transmembrane transporter activity +is_a: GO:0015300 ! solute:solute antiporter activity +is_a: GO:0015490 ! cadaverine transmembrane transporter activity + +[Term] +id: GO:0015498 +name: pantothenate:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] +subset: gosubset_prok +is_a: GO:0015233 ! pantothenate transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015499 +name: formate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015500 +name: threonine/serine:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005283 +consider: GO:0015194 +consider: GO:0015195 + +[Term] +id: GO:0015501 +name: glutamate:sodium symporter activity +namespace: molecular_function +alt_id: GO:0008027 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] +synonym: "sodium/excitatory glutamate cotransporter activity" EXACT [] +synonym: "sodium/excitatory glutamate symporter activity" EXACT [] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0005313 ! L-glutamate transmembrane transporter activity + +[Term] +id: GO:0015503 +name: glutathione-regulated potassium exporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] +subset: gosubset_prok +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015504 +name: cytosine:hydrogen ion symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] +synonym: "cytosine permease activity" RELATED [] +is_a: GO:0015209 ! cytosine transmembrane transporter activity +is_a: GO:0015391 ! nucleobase:cation symporter activity + +[Term] +id: GO:0015505 +name: uracil:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport] +subset: gosubset_prok +synonym: "uracil permease activity" RELATED [] +is_a: GO:0015210 ! uracil transmembrane transporter activity +is_a: GO:0015391 ! nucleobase:cation symporter activity + +[Term] +id: GO:0015506 +name: nucleoside:hydrogen symporter activity +namespace: molecular_function +alt_id: GO:0015536 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1] +synonym: "nucleoside permease activity" RELATED [] +synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] +synonym: "nucleoside:proton symporter" EXACT [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity + +[Term] +id: GO:0015507 +name: hydroxy/aromatic amino acid permease activity +namespace: molecular_function +def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai] +comment: This term was made obsolete because it is a redundant grouping term. +is_obsolete: true +consider: GO:0015171 +consider: GO:0015173 + +[Term] +id: GO:0015513 +name: nitrite uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nitrite from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "nitrite uptake permease activity" EXACT [] +is_a: GO:0015113 ! nitrite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0015514 +name: nitrite efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "nitrite extrusion permease activity" EXACT [] +is_a: GO:0015113 ! nitrite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0015515 +name: citrate:succinate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] +subset: gosubset_prok +is_a: GO:0015137 ! citrate transmembrane transporter activity +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0015516 +name: tartrate:succinate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015554 ! tartrate transmembrane transporter activity + +[Term] +id: GO:0015517 +name: galactose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] +subset: gosubset_prok +synonym: "galactose:proton symporter" EXACT [] +synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0009679 ! hexose:hydrogen symporter activity + +[Term] +id: GO:0015518 +name: arabinose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2] +synonym: "arabinose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0015519 +name: D-xylose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] +subset: gosubset_prok +synonym: "D-xylose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015148 ! D-xylose transmembrane transporter activity + +[Term] +id: GO:0015520 +name: tetracycline:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4] +subset: gosubset_prok +synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] +synonym: "tetracyclin:proton antiporter activity" EXACT [] +synonym: "tetracycline:proton antiporter" EXACT [] +is_a: GO:0008493 ! tetracycline transporter activity +is_a: GO:0015307 ! drug:hydrogen antiporter activity + +[Term] +id: GO:0015521 +name: bicyclomycin/sulfathiazole:hydrogen antiporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "bicyclomycin/sulfathiazole:proton antiporter" EXACT [] +synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT [] +is_obsolete: true +consider: GO:0015545 +consider: GO:0015546 +consider: GO:0045119 + +[Term] +id: GO:0015522 +name: hydrophobic uncoupler:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9] +synonym: "hydrophobic uncoupler:proton antiporter" EXACT [] +is_a: GO:0015307 ! drug:hydrogen antiporter activity +is_a: GO:0017077 ! oxidative phosphorylation uncoupler activity + +[Term] +id: GO:0015523 +name: arabinose efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of arabinose from the inside of the cell to the outside of the cell across a membrane: H+(out) + arabinose(in) = H+(in) + arabinose(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.2.14] +synonym: "arabinose efflux permease activity" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0015524 +name: L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15] +comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function. +synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter" EXACT [] +is_obsolete: true +consider: GO:0015147 +consider: GO:0015299 +consider: GO:0051119 + +[Term] +id: GO:0015525 +name: carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter" EXACT [] +is_obsolete: true +replaced_by: GO:0015307 +replaced_by: GO:0015547 +replaced_by: GO:0015548 +replaced_by: GO:0015549 + +[Term] +id: GO:0015526 +name: hexose-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0015527 +name: glycerol-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0015528 +name: lactose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] +synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] +synonym: "lactose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015155 ! lactose transmembrane transporter activity + +[Term] +id: GO:0015529 +name: raffinose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] +synonym: "raffinose:proton symporter" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015158 ! raffinose transmembrane transporter activity + +[Term] +id: GO:0015530 +name: shikimate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of shikimate from one side of the membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015531 +name: citrate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] +synonym: "citrate:proton symporter" EXACT [] +is_a: GO:0015137 ! citrate transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity + +[Term] +id: GO:0015532 +name: alpha-ketoglutarate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2] +subset: gosubset_prok +synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] +synonym: "2-oxoglutarate:proton symporter" EXACT [] +synonym: "alpha-ketoglutarate:proton symporter" EXACT [] +is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015533 +name: shikimate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] +synonym: "shikimate:proton symporter" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015296 ! anion:cation symporter activity +is_a: GO:0015530 ! shikimate transmembrane transporter activity + +[Term] +id: GO:0015534 +name: proline/glycine/betaine:hydrogen/sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT [] +is_obsolete: true +consider: GO:0015187 +consider: GO:0015193 +consider: GO:0015199 +consider: GO:0015294 +consider: GO:0015295 +consider: GO:0015370 + +[Term] +id: GO:0015535 +name: fucose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1] +synonym: "fucose:proton symporter" EXACT [] +is_a: GO:0009679 ! hexose:hydrogen symporter activity +is_a: GO:0015150 ! fucose transmembrane transporter activity + +[Term] +id: GO:0015537 +name: xanthosine:hydrogen ion symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] +synonym: "xanthosine permease activity" RELATED [] +is_a: GO:0015506 ! nucleoside:hydrogen symporter activity +is_a: GO:0015553 ! xanthosine transmembrane transporter activity + +[Term] +id: GO:0015538 +name: sialic acid:hydrogen ion symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1] +subset: gosubset_prok +synonym: "sialic acid permease activity" RELATED [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015136 ! sialic acid transmembrane transporter activity + +[Term] +id: GO:0015539 +name: hexuronate:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2] +synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] +synonym: "hexuronate porter activity" RELATED [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015134 ! hexuronate transmembrane transporter activity + +[Term] +id: GO:0015540 +name: 3-hydroxyphenyl propionate:hydrogen ion symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] +synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] +is_a: GO:0015293 ! symporter activity +is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity + +[Term] +id: GO:0015541 +name: secondary active cyanate uptake transmembrane transporter +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cyanate(out) = cyanate(in)." [TC:2.A.1.17.1] +synonym: "cyanate porter activity" RELATED [] +is_a: GO:0015110 ! cyanate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015542 +name: sugar efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(in) = sugar(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.20.1] +subset: gosubset_prok +synonym: "lactose/glucose efflux transporter activity" NARROW [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity + +[Term] +id: GO:0015543 +name: lactose/glucose efflux transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2] +comment: This term was made obsolete because it represents two molecular functions. +is_obsolete: true +consider: GO:0005355 +consider: GO:0015155 +consider: GO:0015542 + +[Term] +id: GO:0015544 +name: phenyl propionate uptake uniporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenyl propionate(out) = phenyl propionate(in)." [GOC:mtg_transport, TC:2.A.1.27.1] +synonym: "phenyl propionate permease activity" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015552 ! propionate transmembrane transporter activity + +[Term] +id: GO:0015545 +name: bicyclomycin transporter activity +namespace: molecular_function +def: "Enables the directed movement of bicyclomycin into, out of, within or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] +subset: gosubset_prok +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] +is_a: GO:0042895 ! antibiotic transporter activity + +[Term] +id: GO:0015546 +name: sulfathiazole transporter activity +namespace: molecular_function +def: "Enables the directed movement of sulfathiazole into, out of, within or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group." [http://cancerweb.ncl.ac.uk/] +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] +synonym: "sulphathiazole transporter activity" EXACT [] +is_a: GO:0045118 ! azole transporter activity + +[Term] +id: GO:0015547 +name: nalidixic acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of nalidixic acid into, out of, within or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [http://cancerweb.ncl.ac.uk/] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] +is_a: GO:0042895 ! antibiotic transporter activity +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0015548 +name: organomercurial transporter activity +namespace: molecular_function +def: "Enables the directed movement of organomercurial compounds into, out of, within or between cells. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0015549 +name: carbonyl cyanide m-chlorophenylhydrazone transporter activity +namespace: molecular_function +def: "Enables the directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [http://cancerweb.ncl.ac.uk/] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] +synonym: "CCCP transporter" EXACT [] +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0015550 +name: galacturonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of galacturonate from one side of the membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] +is_a: GO:0015134 ! hexuronate transmembrane transporter activity + +[Term] +id: GO:0015551 +name: 3-hydroxyphenyl propanoate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of 3-hydroxyphenyl propanoate from one side of the membrane to the other." [GOC:ai] +synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT [] +is_a: GO:0015552 ! propionate transmembrane transporter activity + +[Term] +id: GO:0015552 +name: propionate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of propionate from one side of the membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015553 +name: xanthosine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity + +[Term] +id: GO:0015554 +name: tartrate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of tartrate from one side of the membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015555 +name: acriflavin resistant pump activity +namespace: molecular_function +is_a: GO:0015566 ! acriflavin transporter activity + +[Term] +id: GO:0015556 +name: C4-dicarboxylate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other." [GOC:krc] +subset: gosubset_prok +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015557 +name: arginine targeting transmembrane transporter activity +namespace: molecular_function +is_a: GO:0008565 ! protein transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015558 +name: p-aminobenzoyl-glutamate uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "p-aminobenzoyl-glutamate uptake permease activity" EXACT [] +is_a: GO:0015563 ! uptake transmembrane transporter activity +is_a: GO:0015569 ! p-aminobenzoyl-glutamate transmembrane transporter activity + +[Term] +id: GO:0015559 +name: multidrug efflux pump activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0015239 ! multidrug transporter activity + +[Term] +id: GO:0015560 +name: L-idonate/D-gluconate:hydrogen symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "L-idonate/D-gluconate:proton symporter" EXACT [] +is_obsolete: true +consider: GO:0015128 +consider: GO:0015295 +consider: GO:0015568 + +[Term] +id: GO:0015561 +name: rhamnose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1] +synonym: "rhamnose:proton symporter" EXACT [] +is_a: GO:0009679 ! hexose:hydrogen symporter activity +is_a: GO:0015153 ! rhamnose transmembrane transporter activity + +[Term] +id: GO:0015562 +name: efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "efflux permease activity" EXACT [] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015563 +name: uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a specific substance or related group of substances from the outside of a cell to the inside across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "cobalt, zinc uptake permease activity" NARROW [] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] +synonym: "uptake permease activity" RELATED [] +synonym: "zinc, cadmium uptake permease activity" NARROW [] +synonym: "zinc, iron permease activity" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015564 +name: multidrug, alkane resistant pump activity +namespace: molecular_function +is_a: GO:0015239 ! multidrug transporter activity +is_a: GO:0015567 ! alkane transporter activity + +[Term] +id: GO:0015565 +name: threonine efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "threonine efflux permease activity" EXACT [] +synonym: "threonine export protein" RELATED [] +synonym: "threonine export transporter activity" EXACT [] +is_a: GO:0015195 ! L-threonine transmembrane transporter activity +is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity + +[Term] +id: GO:0015566 +name: acriflavin transporter activity +namespace: molecular_function +def: "Enables the directed movement of acriflavin into, out of, within or between cells. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0015238 ! drug transporter activity +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0015567 +name: alkane transporter activity +namespace: molecular_function +def: "Enables the directed movement of alkanes into, out of, within or between cells. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0015568 +name: L-idonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-idonate from one side of the membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] +subset: gosubset_prok +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015569 +name: p-aminobenzoyl-glutamate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai] +subset: gosubset_prok +synonym: "p-aminobenzoyl-glutamate transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015570 +name: energizer of outer membrane receptor-mediated transport activity +namespace: molecular_function +is_a: GO:0015404 ! ion-gradient-driven energizer activity + +[Term] +id: GO:0015571 +name: N-acetylgalactosamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015590 +def: "Catalysis of the transfer of N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "N-acetylgalactosamine permease activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015572 +name: N-acetylglucosamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015580 +def: "Catalysis of the transfer of N-acetylglucosamine from one side of the membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "D-GlcNAc transmembrane transporter activity" EXACT [] +synonym: "N-Acetyl-D-glucosamine permease" RELATED [] +synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT [] +synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT [] +synonym: "N-acetylglucosamine permease activity" RELATED [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015573 +name: beta-glucoside transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015582 +def: "Catalysis of the transfer of beta-glucosides from one side of the membrane to the other. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "beta-glucoside permease activity" EXACT [] +is_a: GO:0042947 ! glucoside transmembrane transporter activity + +[Term] +id: GO:0015574 +name: trehalose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015584 +def: "Catalysis of the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "trehalose permease activity" EXACT [] +is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0015575 +name: mannitol transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015586 +def: "Catalysis of the transfer of mannitol from one side of the membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "mannitol permease activity" EXACT [] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015576 +name: sorbitol transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015587 +def: "Catalysis of the transfer of sorbitol from one side of the membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucitol permease activity" EXACT [] +synonym: "glucitol transporter activity" EXACT [] +synonym: "sorbitol permease activity" EXACT [] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015577 +name: galactitol transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015588 +def: "Catalysis of the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "galactitol permease activity" EXACT [] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015578 +name: mannose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015589 +def: "Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "mannose permease activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015583 +name: beta-glucoside [arbutin-salicin-cellobiose] permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it arbitrarily groups three substrates. +is_obsolete: true + +[Term] +id: GO:0015591 +name: D-ribose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-ribose from one side of the membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015146 ! pentose transmembrane transporter activity + +[Term] +id: GO:0015592 +name: methylgalactoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of methylgalactoside from one side of the membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] +subset: gosubset_prok +synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015593 +name: allose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of allose from one side of the membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015594 +name: putrescine-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + putrescine(out) = ADP + phosphate + putrescine(in)." [EC:3.6.3.31] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "putrescine porter activity" BROAD [] +is_a: GO:0015417 ! polyamine-transporting ATPase activity +is_a: GO:0015489 ! putrescine transmembrane transporter activity + +[Term] +id: GO:0015595 +name: spermidine-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + spermidine(out) = ADP + phosphate + spermidine(in)." [EC:3.6.3.31] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "spermidine porter activity" BROAD [] +is_a: GO:0015417 ! polyamine-transporting ATPase activity +is_a: GO:0015606 ! spermidine transmembrane transporter activity + +[Term] +id: GO:0015596 +name: glycine betaine/proline porter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015187 +consider: GO:0015193 +consider: GO:0015199 +consider: GO:0015418 + +[Term] +id: GO:0015597 +name: histidine/arginine/lysine/ornithine porter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0000064 +consider: GO:0005290 +consider: GO:0015181 +consider: GO:0015189 +consider: GO:0015426 + +[Term] +id: GO:0015598 +name: arginine-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arginine(out) = ADP + phosphate + arginine(in)." [EC:3.6.3.21] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "arginine porter activity" EXACT [] +is_a: GO:0015181 ! arginine transmembrane transporter activity +is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity + +[Term] +id: GO:0015599 +name: glutamine-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) = ADP + phosphate + glutamine(in)." [EC:3.6.3.21] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "glutamine porter activity" BROAD [] +is_a: GO:0015186 ! L-glutamine transmembrane transporter activity +is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity + +[Term] +id: GO:0015600 +name: glutamate/aspartate porter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005313 +consider: GO:0015183 +consider: GO:0015426 + +[Term] +id: GO:0015601 +name: cystine/diaminopimelate porter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0015184 +consider: GO:0015426 +consider: GO:0015626 + +[Term] +id: GO:0015602 +name: leucine/isoleucine/valine porter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005304 +consider: GO:0015188 +consider: GO:0015190 +consider: GO:0015425 + +[Term] +id: GO:0015603 +name: iron chelate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] +subset: gosubset_prok +is_a: GO:0005381 ! iron ion transmembrane transporter activity + +[Term] +id: GO:0015604 +name: phosphonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015605 +name: organophosphate ester transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015606 +name: spermidine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of the membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015203 ! polyamine transmembrane transporter activity + +[Term] +id: GO:0015607 +name: fatty acyl CoA transporter activity +namespace: molecular_function +def: "Enables the directed movement of a fatty acyl CoA group into, out of, within or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A moiety attached to it." [GOC:ai] +is_a: GO:0015246 ! fatty acyl transporter activity + +[Term] +id: GO:0015608 +name: carbohydrate-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) = ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "carbohydrate uptake transporter activity" EXACT [] +synonym: "sugar transporter" NARROW [] +is_a: GO:0043211 ! carbohydrate-transporting ATPase activity + +[Term] +id: GO:0015609 +name: maltooligosaccharide-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltooligosaccharide(out) = ADP + phosphate + maltooligosaccharide(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "maltooligosaccharide porter activity" BROAD [] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity +is_a: GO:0015608 ! carbohydrate-importing ATPase activity + +[Term] +id: GO:0015610 +name: glycerol phosphate-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-phosphate(out) = ADP + phosphate + glycerol-phosphate(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "glycerol-phosphate porter activity" BROAD [] +is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity +is_a: GO:0015608 ! carbohydrate-importing ATPase activity + +[Term] +id: GO:0015611 +name: D-ribose-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "D-ribose porter activity" BROAD [] +is_a: GO:0015407 ! monosaccharide-transporting ATPase activity +is_a: GO:0015591 ! D-ribose transmembrane transporter activity + +[Term] +id: GO:0015612 +name: L-arabinose-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) = ADP + phosphate + L-arabinose(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "L-arabinose porter activity" EXACT [] +is_a: GO:0015147 ! L-arabinose transmembrane transporter activity +is_a: GO:0015407 ! monosaccharide-transporting ATPase activity + +[Term] +id: GO:0015613 +name: galactose/glucose (methylgalactoside) porter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +is_obsolete: true +consider: GO:0005354 +consider: GO:0005355 +consider: GO:0015291 +consider: GO:0015592 + +[Term] +id: GO:0015614 +name: D-xylose-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "D-xylose porter activity" BROAD [] +is_a: GO:0015148 ! D-xylose transmembrane transporter activity +is_a: GO:0015407 ! monosaccharide-transporting ATPase activity + +[Term] +id: GO:0015615 +name: D-allose-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) = ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "D-allose porter activity" BROAD [] +is_a: GO:0015593 ! allose transmembrane transporter activity +is_a: GO:0015608 ! carbohydrate-importing ATPase activity + +[Term] +id: GO:0015616 +name: DNA translocase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491] +comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. +is_a: GO:0003677 ! DNA binding +is_a: GO:0008094 ! DNA-dependent ATPase activity + +[Term] +id: GO:0015617 +name: pilin/fimbrilin exporter activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0015462 + +[Term] +id: GO:0015619 +name: thiamin pyrophosphate-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamin pyrophosphate(out) = ADP + phosphate + thiamin pyrophosphate(in)." [TC:3.A.1.19.1] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "thiamin pyrophosphate ABC transporter" NARROW [] +synonym: "thiamin pyrophosphate porter activity" BROAD [] +synonym: "thiamine pyrophosphate transporting ATPase activity" EXACT [] +synonym: "TPP transporting ATPase activity" EXACT [] +is_a: GO:0015234 ! thiamin transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015620 +name: ferric-enterobactin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity + +[Term] +id: GO:0015621 +name: ferric triacetylfusarinine C transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015091 ! ferric iron transmembrane transporter activity + +[Term] +id: GO:0015622 +name: ferric-hydroxamate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ferric-hydroxamate from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity + +[Term] +id: GO:0015623 +name: iron-chelate-transporting ATPase activity +namespace: molecular_function +alt_id: GO:0015409 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:3.6.3.34] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:3.6.3.34] +synonym: "ferric/ferric-dicitrate porter" BROAD [] +synonym: "iron-chelate ABC transporter" NARROW [] +xref: EC:3.6.3.34 +xref: MetaCyc:3.6.3.34-RXN +is_a: GO:0015603 ! iron chelate transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0015624 +name: ferric-enterobactin-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ferric-enterobactin ABC transporter" NARROW [] +synonym: "ferric-enterobactin porter activity" BROAD [] +is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity +is_a: GO:0015623 ! iron-chelate-transporting ATPase activity + +[Term] +id: GO:0015625 +name: ferric-hydroxamate-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [TC:3.A.1.-.-] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ferric-hydroxamate ABC transporter" NARROW [] +synonym: "ferric-hydroxamate porter activity" BROAD [] +is_a: GO:0015622 ! ferric-hydroxamate transmembrane transporter activity +is_a: GO:0015623 ! iron-chelate-transporting ATPase activity + +[Term] +id: GO:0015626 +name: L-diaminopimelate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the levorotatory isomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +synonym: "cystine/diaminopimelate porter activity" NARROW [] +synonym: "L-diaminopimelate transporter activity" BROAD [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015627 +name: type II protein secretion system complex +namespace: cellular_component +def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] +comment: The type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. +subset: gosubset_prok +synonym: "general secretion pathway-associated complex" RELATED [] +synonym: "main terminal branch" EXACT [] +synonym: "MTB" EXACT [] +synonym: "Sec-dependent secretion system-associated complex" RELATED [] +synonym: "T2SS-associated complexes" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0015628 +name: protein secretion by the type II secretion system +namespace: biological_process +def: "The process by which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. +subset: gosubset_prok +synonym: "protein secretion by the general secretion pathway [sensu Bacteria]" RELATED [] +synonym: "protein secretion by the general secretory pathway [sensu Bacteria]" RELATED [] +synonym: "protein secretion by the T2S" EXACT [] +synonym: "protein secretion by the T2SS" EXACT [] +synonym: "protein secretion by the type II protein secretion system" EXACT [] +synonym: "type II protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0015629 +name: actin cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0395825172] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0015630 +name: microtubule cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0015631 +name: tubulin binding +namespace: molecular_function +def: "Interacting selectively with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0015633 +name: zinc transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-] +synonym: "zinc porter activity" RELATED [] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0015634 +name: lipopolysaccharide exporter activity +namespace: molecular_function +def: "Catalysis of the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729] +synonym: "LPS exporter activity" EXACT [] +is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0015635 +name: short-chain fatty acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of short-chain fatty acids into, out of, within or between cells. Short-chain fatty acids have a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015245 ! fatty acid transporter activity + +[Term] +id: GO:0015636 +name: short-chain fatty acid uptake transporter activity +namespace: molecular_function +is_a: GO:0015635 ! short-chain fatty acid transporter activity + +[Term] +id: GO:0015638 +name: microcin uptake permease activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0015197 ! peptide transporter activity +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0015639 +name: ferrous iron uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in)." [TC:9.A.8.1.1] +subset: gosubset_prok +is_a: GO:0015093 ! ferrous iron transmembrane transporter activity + +[Term] +id: GO:0015640 +name: peptidoglycan peptide transporter activity +namespace: molecular_function +def: "Enables the directed movement of peptidoglycan peptides into, out of, within or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "murein peptide transporter activity" EXACT [] +synonym: "muropeptide transporter activity" EXACT [] +is_a: GO:0015197 ! peptide transporter activity +is_a: GO:0015647 ! peptidoglycan transporter activity + +[Term] +id: GO:0015641 +name: lipoprotein toxin +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0009405 +replaced_by: GO:0050827 + +[Term] +id: GO:0015642 +name: bacteriolytic toxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +comment: This term was made obsolete because it represents a class of gene products and not a molecular function. +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015643 +name: toxin binding +namespace: molecular_function +def: "Interacting selectively with a toxin, a poisonous substance that causes damage to biological systems. Toxins are differentiated from simple chemical poisons and vegetable alkaloids by their high molecular weight and antigenicity (they elicit an antibody response)." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "antitoxin activity" RELATED [] +synonym: "lipoprotein antitoxin" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0015644 +name: lipoprotein antitoxin +namespace: molecular_function +def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl] +comment: This term was made obsolete because it does not represent a function distinct from its parent term. +is_obsolete: true +replaced_by: GO:0015643 + +[Term] +id: GO:0015645 +name: fatty-acid ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of a long-chain carboxylic acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.20, EC:6.2.1.3, GOC:mah] +subset: gosubset_prok +synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3] +synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] +synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3] +synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3] +synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] +xref: EC:6.2.1.- +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0015647 +name: peptidoglycan transporter activity +namespace: molecular_function +def: "Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "murein transporter activity" EXACT [] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0015648 +name: lipid-linked peptidoglycan transporter activity +namespace: molecular_function +synonym: "lipid-linked murein transporter activity" EXACT [] +is_a: GO:0015647 ! peptidoglycan transporter activity + +[Term] +id: GO:0015649 +name: 2-keto-3-deoxygluconate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1] +subset: gosubset_prok +synonym: "2-keto-3-deoxygluconate:proton symporter" EXACT [] +is_a: GO:0005402 ! cation:sugar symporter activity +is_a: GO:0015128 ! gluconate transmembrane transporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015650 +name: lactate:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1] +synonym: "lactate permease" BROAD [] +synonym: "lactate:hydrogen porter activity" EXACT [] +synonym: "lactate:proton porter" EXACT [] +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015651 +name: quaternary ammonium group transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015202 +def: "Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "quaternary amine transmembrane transporter activity" EXACT [] +synonym: "quaternary ammonium compound transporter activity" EXACT [] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0015652 +name: quaternary ammonium group:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "quaternary ammonium group:proton symporter" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity + +[Term] +id: GO:0015653 +name: glycine betaine:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] +subset: gosubset_prok +synonym: "glycine betaine:proton symporter" EXACT [] +is_a: GO:0015652 ! quaternary ammonium group:hydrogen symporter activity + +[Term] +id: GO:0015654 +name: tellurite uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of tellurite from the outside of a cell to the inside across a membrane: tellurite(out) + H+(out) = tellurite(in) + H+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.16.1.1] +synonym: "tellurite-resistance uptake permease activity" EXACT [] +synonym: "tellurite-resistance uptake transmembrane transporter activity" EXACT [] +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0015655 +name: alanine:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity + +[Term] +id: GO:0015657 +name: branched-chain amino acid:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] +is_a: GO:0005283 ! sodium:amino acid symporter activity +is_a: GO:0015658 ! branched-chain aliphatic amino acid transmembrane transporter activity + +[Term] +id: GO:0015658 +name: branched-chain aliphatic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of branched-chain aliphatic amino acids from one side of a membrane to the other. Branched-chain aliphatic amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "branched-chain aliphatic amino acid transporter activity" BROAD [] +synonym: "leucine/valine/isoleucine permease activity" RELATED [] +synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015659 +name: formate uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of formate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "formate uptake permease activity" EXACT [] +is_a: GO:0015499 ! formate transmembrane transporter activity +is_a: GO:0015563 ! uptake transmembrane transporter activity + +[Term] +id: GO:0015660 +name: formate efflux transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015509 +def: "Catalysis of the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "formate efflux permease activity" EXACT [] +is_a: GO:0015499 ! formate transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0015661 +name: L-lysine efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "L-lysine exporter activity" EXACT [] +synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT [] +is_a: GO:0015189 ! L-lysine transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0015662 +name: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "P-type ATPase activity" EXACT [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions + +[Term] +id: GO:0015663 +name: nicotinamide mononucleotide transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015664 +def: "Enables the directed movement of nicotinamide mononucleotide into, out of, within or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "nicotinamide mononucleotide permease activity" RELATED [] +synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0015665 +name: alcohol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0015666 +name: restriction endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg] +subset: gosubset_prok +synonym: "restriction endonuclease activity" EXACT [] +synonym: "restriction enzyme activity" EXACT [] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0015667 +name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113] +subset: gosubset_prok +synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113] +synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113] +synonym: "modification methylase activity" RELATED [EC:2.1.1.113] +synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] +synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] +synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113] +synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113] +synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113] +xref: EC:2.1.1.113 +xref: MetaCyc:2.1.1.113-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0009008 ! DNA-methyltransferase activity + +[Term] +id: GO:0015668 +name: Type III site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995] +subset: gosubset_prok +synonym: "Type III restriction enzyme activity" EXACT [] +xref: EC:3.1.21.5 +xref: MetaCyc:3.1.21.5-RXN +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0015669 +name: gas transport +namespace: biological_process +def: "The directed movement of substances that are gaseous in normal living conditions into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015670 +name: carbon dioxide transport +namespace: biological_process +def: "The directed movement of carbon dioxide (CO2) into, out of, within or between cells." [GOC:ai] +is_a: GO:0015669 ! gas transport + +[Term] +id: GO:0015671 +name: oxygen transport +namespace: biological_process +def: "The directed movement of oxygen (O2) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015669 ! gas transport + +[Term] +id: GO:0015672 +name: monovalent inorganic cation transport +namespace: biological_process +def: "The directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai] +subset: gosubset_prok +synonym: "univalent inorganic cation transport" EXACT [] +is_a: GO:0006812 ! cation transport + +[Term] +id: GO:0015673 +name: silver ion transport +namespace: biological_process +def: "The directed movement of silver (Ag) ions into, out of, within or between cells." [GOC:ai] +synonym: "silver transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0015672 ! monovalent inorganic cation transport + +[Term] +id: GO:0015674 +name: di-, tri-valent inorganic cation transport +namespace: biological_process +def: "The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006812 ! cation transport + +[Term] +id: GO:0015675 +name: nickel ion transport +namespace: biological_process +def: "The directed movement of nickel (Ni) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0015676 +name: vanadium ion transport +namespace: biological_process +def: "The directed movement of vanadium (V) ions into, out of, within or between cells." [GOC:ai] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0015677 +name: copper ion import +namespace: biological_process +def: "The directed movement of copper ions into a cell or organelle." [GOC:ai] +synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0015678 +name: high-affinity copper ion transport +namespace: biological_process +def: "The directed, high-affinity movement of copper (Cu) ions into, out of, within or between cells. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +synonym: "high affinity copper ion transport" EXACT [] +synonym: "high affinity copper transport" EXACT [] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0015679 +name: plasma membrane copper ion transport +namespace: biological_process +def: "The directed movement of copper ions across the plasma membrane." [GOC:ai] +synonym: "plasma membrane copper transport" EXACT [] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0015680 +name: intracellular copper ion transport +namespace: biological_process +def: "The directed movement of copper (Cu) ions within a cell." [GOC:ai] +synonym: "intracellular copper delivery" EXACT [] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0015682 +name: ferric iron transport +namespace: biological_process +def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "ferric ion transport" EXACT [] +is_a: GO:0006826 ! iron ion transport + +[Term] +id: GO:0015683 +name: high-affinity ferric iron transport +namespace: biological_process +def: "The directed, high-affinity movement of ferric (Fe(III) or Fe3+) ions into, out of, within or between cells. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +synonym: "high affinity ferric iron transport" EXACT [] +is_a: GO:0006827 ! high-affinity iron ion transport +is_a: GO:0015682 ! ferric iron transport + +[Term] +id: GO:0015684 +name: ferrous iron transport +namespace: biological_process +def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "ferrous ion transport" EXACT [] +is_a: GO:0006826 ! iron ion transport + +[Term] +id: GO:0015685 +name: ferric-enterobactin transport +namespace: biological_process +def: "The directed movement of ferric-enterobactin into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015682 ! ferric iron transport +is_a: GO:0015892 ! siderophore-iron transport +is_a: GO:0042930 ! enterobactin transport + +[Term] +id: GO:0015686 +name: ferric triacetylfusarinine C transport +namespace: biological_process +def: "The directed movement of ferric triacetylfusarinine C into, out of, within or between cells." [GOC:ai] +is_a: GO:0015682 ! ferric iron transport +is_a: GO:0015892 ! siderophore-iron transport + +[Term] +id: GO:0015687 +name: ferric-hydroxamate transport +namespace: biological_process +def: "The directed movement of ferric-hydroxamate into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015682 ! ferric iron transport +is_a: GO:0015892 ! siderophore-iron transport + +[Term] +id: GO:0015688 +name: iron chelate transport +namespace: biological_process +def: "The directed movement of iron chelates into, out of, within or between cells. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006826 ! iron ion transport + +[Term] +id: GO:0015689 +name: molybdate ion transport +namespace: biological_process +def: "The directed movement of molybdate (MoO4 2-) ions into, out of, within or between cells. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015690 +name: aluminum ion transport +namespace: biological_process +def: "The directed movement of aluminum (Al) ions into, out of, within or between cells." [GOC:ai] +synonym: "aluminium ion transport" EXACT [] +synonym: "aluminium transport" EXACT [] +synonym: "aluminum transport" EXACT [] +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0015691 +name: cadmium ion transport +namespace: biological_process +def: "The directed movement of cadmium (Cd) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "cadmium transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport + +[Term] +id: GO:0015692 +name: lead ion transport +namespace: biological_process +def: "The directed movement of lead (Pb) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0015693 +name: magnesium ion transport +namespace: biological_process +def: "The directed movement of magnesium (Mg) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "magnesium transport" RELATED [] +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0015694 +name: mercury ion transport +namespace: biological_process +def: "The directed movement of mercury (Hg) ions into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "mercuric ion transport" NARROW [] +synonym: "mercury transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0015674 ! di-, tri-valent inorganic cation transport +relationship: part_of GO:0050787 ! detoxification of mercury ion + +[Term] +id: GO:0015695 +name: organic cation transport +namespace: biological_process +def: "The directed movement of organic cations into, out of, within or between cells. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006812 ! cation transport + +[Term] +id: GO:0015696 +name: ammonium transport +namespace: biological_process +def: "The directed movement of ammonium into, out of, within or between cells. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ammonia transport" RELATED [] +is_a: GO:0015695 ! organic cation transport + +[Term] +id: GO:0015697 +name: quaternary ammonium group transport +namespace: biological_process +alt_id: GO:0015845 +def: "The directed movement into, out of, within or between cells of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "quaternary amine transport" EXACT [] +synonym: "quaternary ammonium compound transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015698 +name: inorganic anion transport +namespace: biological_process +def: "The directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] +subset: gosubset_prok +is_a: GO:0006820 ! anion transport + +[Term] +id: GO:0015699 +name: antimonite transport +namespace: biological_process +def: "The directed movement of antimonite into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015700 +name: arsenite transport +namespace: biological_process +def: "The directed movement of arsenite into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015701 +name: bicarbonate transport +namespace: biological_process +def: "The directed movement of bicarbonate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015702 +name: chlorate transport +namespace: biological_process +def: "The directed movement of chlorate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015703 +name: chromate transport +namespace: biological_process +def: "The directed movement of chromate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015704 +name: cyanate transport +namespace: biological_process +def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015705 +name: iodide transport +namespace: biological_process +def: "The directed movement of iodide into, out of, within or between cells." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015706 +name: nitrate transport +namespace: biological_process +alt_id: GO:0006872 +def: "The directed movement of nitrate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015707 +name: nitrite transport +namespace: biological_process +def: "The directed movement of nitrite into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015708 +name: silicate transport +namespace: biological_process +def: "The directed movement of silicates into, out of, within or between cells. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015709 +name: thiosulfate transport +namespace: biological_process +def: "The directed movement of thiosulfate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +synonym: "thiosulphate transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015710 +name: tellurite transport +namespace: biological_process +def: "The directed movement of tellurite into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015711 +name: organic anion transport +namespace: biological_process +def: "The directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] +subset: gosubset_prok +is_a: GO:0006820 ! anion transport + +[Term] +id: GO:0015712 +name: hexose phosphate transport +namespace: biological_process +def: "The directed movement of hexose phosphate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015713 +name: phosphoglycerate transport +namespace: biological_process +def: "The directed movement of phosphoglycerate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015714 +name: phosphoenolpyruvate transport +namespace: biological_process +def: "The directed movement of phosphoenolpyruvate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0015715 +name: nucleotide-sulfate transport +namespace: biological_process +synonym: "nucleotide-sulphate transport" EXACT [] +is_a: GO:0008272 ! sulfate transport + +[Term] +id: GO:0015716 +name: phosphonate transport +namespace: biological_process +def: "The directed movement of phosphonates into, out of, within or between cells. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0015717 +name: triose phosphate transport +namespace: biological_process +def: "The directed movement of triose phosphate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015749 ! monosaccharide transport + +[Term] +id: GO:0015718 +name: monocarboxylic acid transport +namespace: biological_process +def: "The directed movement of monocarboxylic acids into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015719 +name: allantoate transport +namespace: biological_process +def: "The directed movement of allantoate into, out of, within or between cells." [GOC:krc] +synonym: "allantoin/allantoate transport" BROAD [] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015720 +name: allantoin transport +namespace: biological_process +def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "allantoin/allantoate transport" BROAD [] +is_a: GO:0015851 ! nucleobase transport + +[Term] +id: GO:0015721 +name: bile acid and bile salt transport +namespace: biological_process +def: "The directed movement of bile acid and bile salts into, out of, within or between cells." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] +synonym: "bile acid transport" NARROW [] +synonym: "bile salt transport" NARROW [] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015722 +name: canalicular bile acid transport +namespace: biological_process +is_a: GO:0015721 ! bile acid and bile salt transport + +[Term] +id: GO:0015723 +name: bilirubin transport +namespace: biological_process +def: "The directed movement of bilirubin into, out of, within or between cells." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015724 +name: formate transport +namespace: biological_process +def: "The directed movement of formate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015725 +name: gluconate transport +namespace: biological_process +def: "The directed movement of gluconate into, out of, within or between cells. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015726 +name: L-idonate transport +namespace: biological_process +def: "The directed movement of L-idonate into, out of, within or between cells. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015727 +name: lactate transport +namespace: biological_process +def: "The directed movement of lactate into, out of, within or between cells. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015728 +name: mevalonate transport +namespace: biological_process +def: "The directed movement of mevalonate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015729 +name: oxaloacetate transport +namespace: biological_process +def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of, within or between cells." [GOC:krc] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015730 +name: propionate transport +namespace: biological_process +def: "The directed movement of propionate into, out of, within or between cells." [GOC:krc] +synonym: "propanoate transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015731 +name: 3-hydroxyphenyl propanoate transport +namespace: biological_process +def: "The directed movement of 3-hydroxyphenyl propanoate into, out of, within or between cells." [GOC:krc] +synonym: "3-hydroxyphenyl propionate transport" EXACT [] +is_a: GO:0015730 ! propionate transport + +[Term] +id: GO:0015732 +name: prostaglandin transport +namespace: biological_process +def: "The directed movement of prostaglandins into, out of, within or between cells." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015733 +name: shikimate transport +namespace: biological_process +def: "The directed movement of shikimate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015734 +name: taurine transport +namespace: biological_process +def: "The directed movement of taurine into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015735 +name: uronic acid transport +namespace: biological_process +def: "The directed movement of uronic acid into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015736 +name: hexuronate transport +namespace: biological_process +def: "The directed movement of hexuronate into, out of, within or between cells. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015735 ! uronic acid transport + +[Term] +id: GO:0015737 +name: galacturonate transport +namespace: biological_process +def: "The directed movement of galacturonate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015736 ! hexuronate transport + +[Term] +id: GO:0015738 +name: glucuronate transport +namespace: biological_process +def: "The directed movement of glucuronate into, out of, within or between cells." [GOC:krc] +is_a: GO:0015736 ! hexuronate transport + +[Term] +id: GO:0015739 +name: sialic acid transport +namespace: biological_process +def: "The directed movement of sialic acid into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015740 +name: C4-dicarboxylate transport +namespace: biological_process +def: "The directed movement of C4-dicarboxylate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015741 +name: fumarate transport +namespace: biological_process +def: "The directed movement of fumarate into, out of, within or between cells." [GOC:krc] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015742 +name: alpha-ketoglutarate transport +namespace: biological_process +def: "The directed movement of alpha-ketoglutarate into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +synonym: "2-oxoglutarate transport" EXACT [] +synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015743 +name: malate transport +namespace: biological_process +def: "The directed movement of malate into, out of, within or between cells." [GOC:krc] +synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015744 +name: succinate transport +namespace: biological_process +def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015745 +name: tartrate transport +namespace: biological_process +def: "The directed movement of tartrate into, out of, within or between cells." [GOC:krc] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015746 +name: citrate transport +namespace: biological_process +def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells." [GOC:krc] +subset: gosubset_prok +is_a: GO:0006842 ! tricarboxylic acid transport + +[Term] +id: GO:0015747 +name: urate transport +namespace: biological_process +def: "The directed movement of urate into, out of, within or between cells." [GOC:krc] +synonym: "uric acid transport" EXACT [] +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015748 +name: organophosphate ester transport +namespace: biological_process +def: "The directed movement of organophosphate esters into, out of, within or between cells. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0015749 +name: monosaccharide transport +namespace: biological_process +def: "The directed movement of monosaccharides into, out of, within or between cells. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015750 +name: pentose transport +namespace: biological_process +def: "The directed movement of pentoses into, out of, within or between cells. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015749 ! monosaccharide transport + +[Term] +id: GO:0015751 +name: arabinose transport +namespace: biological_process +def: "The directed movement of arabinose, a pentose monosaccharide that occurs in both D and L configurations, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0015750 ! pentose transport + +[Term] +id: GO:0015752 +name: D-ribose transport +namespace: biological_process +def: "The directed movement of D-ribose into, out of, within or between cells. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015750 ! pentose transport + +[Term] +id: GO:0015753 +name: D-xylose transport +namespace: biological_process +def: "The directed movement of D-xylose into, out of, within or between cells. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015750 ! pentose transport + +[Term] +id: GO:0015754 +name: allose transport +namespace: biological_process +def: "The directed movement of allose into, out of, within or between cells. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015755 +name: fructose transport +namespace: biological_process +def: "The directed movement of fructose into, out of, within or between cells. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015756 +name: fucose transport +namespace: biological_process +def: "The directed movement of fucose into, out of, within or between cells. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015757 +name: galactose transport +namespace: biological_process +def: "The directed movement of galactose into, out of, within or between cells. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015758 +name: glucose transport +namespace: biological_process +def: "The directed movement of the hexose monosaccharide glucose into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015759 +name: beta-glucoside transport +namespace: biological_process +def: "The directed movement of beta-glucosides into, out of, within or between cells. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0042946 ! glucoside transport + +[Term] +id: GO:0015760 +name: glucose-6-phosphate transport +namespace: biological_process +def: "The directed movement of glucose-6-phosphate into, out of, within or between cells. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] +is_a: GO:0015758 ! glucose transport + +[Term] +id: GO:0015761 +name: mannose transport +namespace: biological_process +def: "The directed movement of mannose into, out of, within or between cells. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015762 +name: rhamnose transport +namespace: biological_process +def: "The directed movement of rhamnose into, out of, within or between cells. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015763 +name: N-acetylgalactosamine transport +namespace: biological_process +def: "The directed movement of N-acetylgalactosamine into, out of, within or between cells. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015764 +name: N-acetylglucosamine transport +namespace: biological_process +def: "The directed movement of N-acetylglucosamine into, out of, within or between cells." [GOC:mah] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015765 +name: methylgalactoside transport +namespace: biological_process +def: "The directed movement of methylgalactoside into, out of, within or between cells. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0015766 +name: disaccharide transport +namespace: biological_process +def: "The directed movement of disaccharides into, out of, within or between cells. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015767 +name: lactose transport +namespace: biological_process +def: "The directed movement of lactose into, out of, within or between cells. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015768 +name: maltose transport +namespace: biological_process +def: "The directed movement of maltose into, out of, within or between cells. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000017 ! alpha-glucoside transport +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015769 +name: melibiose transport +namespace: biological_process +def: "The directed movement of melibiose into, out of, within or between cells. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015770 +name: sucrose transport +namespace: biological_process +def: "The directed movement of sucrose into, out of, within or between cells. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015771 +name: trehalose transport +namespace: biological_process +def: "The directed movement of trehalose into, out of, within or between cells. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000017 ! alpha-glucoside transport +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015772 +name: oligosaccharide transport +namespace: biological_process +def: "The directed movement of oligosaccharides into, out of, within or between cells. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015773 +name: raffinose transport +namespace: biological_process +def: "The directed movement of raffinose into, out of, within or between cells. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:0015774 +name: polysaccharide transport +namespace: biological_process +def: "The directed movement of polysaccharides into, out of, within or between cells. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015775 +name: beta-glucan transport +namespace: biological_process +def: "The directed movement of beta-glucans into, out of, within or between cells. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai] +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0015776 +name: capsular polysaccharide transport +namespace: biological_process +def: "The directed movement of capsular polysaccharides into, out of, within or between cells. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] +subset: gosubset_prok +synonym: "capsular-polysaccharide transport" EXACT [] +synonym: "capsule polysaccharide transport" EXACT [] +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0015777 +name: teichoic acid transport +namespace: biological_process +def: "The directed movement of teichoic acid into, out of, within or between cells. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0015778 +name: hexuronide transport +namespace: biological_process +def: "The directed movement of hexuronide into, out of, within or between cells. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015779 +name: glucuronoside transport +namespace: biological_process +def: "The directed movement of glucuronosides into, out of, within or between cells. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai] +subset: gosubset_prok +synonym: "glucuronide transport" EXACT [] +is_a: GO:0015778 ! hexuronide transport + +[Term] +id: GO:0015780 +name: nucleotide-sugar transport +namespace: biological_process +def: "The directed movement of nucleotide-sugars into, out of, within or between cells. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015781 +name: pyrimidine nucleotide-sugar transport +namespace: biological_process +def: "The directed movement of pyrimidine nucleotide-sugars into, out of, within or between cells. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai] +is_a: GO:0015780 ! nucleotide-sugar transport + +[Term] +id: GO:0015782 +name: CMP-sialic acid transport +namespace: biological_process +def: "The directed movement of CMP-sialic acid into, out of, within or between cells. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015783 +name: GDP-fucose transport +namespace: biological_process +def: "The directed movement of GDP-fucose into, out of, within or between cells. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015784 +name: GDP-mannose transport +namespace: biological_process +def: "The directed movement of GDP-mannose into, out of, within or between cells. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015785 +name: UDP-galactose transport +namespace: biological_process +def: "The directed movement of UDP-galactose into, out of, within or between cells. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015786 +name: UDP-glucose transport +namespace: biological_process +def: "The directed movement of UDP-glucose into, out of, within or between cells. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015787 +name: UDP-glucuronic acid transport +namespace: biological_process +def: "The directed movement of UDP-glucuronic acid into, out of, within or between cells. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015788 +name: UDP-N-acetylglucosamine transport +namespace: biological_process +def: "The directed movement of UDP-N-acetylglucosamine into, out of, within or between cells. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015789 +name: UDP-N-acetylgalactosamine transport +namespace: biological_process +def: "The directed movement of UDP-N-acetylgalactosamine into, out of, within or between cells. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015790 +name: UDP-xylose transport +namespace: biological_process +def: "The directed movement of UDP-xylose into, out of, within or between cells. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] +is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport + +[Term] +id: GO:0015791 +name: polyol transport +namespace: biological_process +def: "The directed movement of polyols, any polyhydric alcohol, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015792 +name: arabinitol transport +namespace: biological_process +def: "The directed movement of arabitol into, out of, within or between cells. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015793 +name: glycerol transport +namespace: biological_process +def: "The directed movement of glycerol into, out of, within or between cells. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015794 +name: glycerol-3-phosphate transport +namespace: biological_process +def: "The directed movement of glycerol-3-phosphate into, out of, within or between cells. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015793 ! glycerol transport + +[Term] +id: GO:0015795 +name: sorbitol transport +namespace: biological_process +def: "The directed movement of sorbitol into, out of, within or between cells. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucitol transport" EXACT [] +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015796 +name: galactitol transport +namespace: biological_process +def: "The directed movement of galactitol into, out of, within or between cells. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015797 +name: mannitol transport +namespace: biological_process +def: "The directed movement of mannitol into, out of, within or between cells. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015798 +name: myo-inositol transport +namespace: biological_process +def: "The directed movement of myo-inositol into, out of, within or between cells. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin Bh transport" EXACT [] +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015799 +name: propanediol transport +namespace: biological_process +def: "The directed movement of propanediol into, out of, within or between cells. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com] +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015800 +name: acidic amino acid transport +namespace: biological_process +def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015801 +name: aromatic amino acid transport +namespace: biological_process +def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015802 +name: basic amino acid transport +namespace: biological_process +def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015803 +name: branched-chain aliphatic amino acid transport +namespace: biological_process +def: "The directed movement of branched-chain aliphatic amino acids, amino acids with branched carbon skeleton without rings, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015804 +name: neutral amino acid transport +namespace: biological_process +def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015805 +name: S-adenosylmethionine transport +namespace: biological_process +def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of, within or between cells." [GOC:ai] +synonym: "S-adenosyl methionine transport" EXACT [] +is_a: GO:0000101 ! sulfur amino acid transport + +[Term] +id: GO:0015806 +name: S-methylmethionine transport +namespace: biological_process +def: "The directed movement of S-methylmethionine into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000101 ! sulfur amino acid transport + +[Term] +id: GO:0015807 +name: L-amino acid transport +namespace: biological_process +def: "The directed movement of levorotatory isomer amino acids into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015808 +name: L-alanine transport +namespace: biological_process +def: "The directed movement of L-alanine, the levorotatory isomer of 2-aminopropanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0032328 ! alanine transport + +[Term] +id: GO:0015809 +name: arginine transport +namespace: biological_process +def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-arginine transport" NARROW [] +is_a: GO:0015802 ! basic amino acid transport + +[Term] +id: GO:0015810 +name: aspartate transport +namespace: biological_process +def: "The directed movement of aspartate, the anion of aspartic acid, into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-aspartate transport" NARROW [] +synonym: "mitochondrial aspartate/glutamate transport" RELATED [] +is_a: GO:0015800 ! acidic amino acid transport + +[Term] +id: GO:0015811 +name: L-cystine transport +namespace: biological_process +def: "The directed movement of L-cystine (also known as dicysteine) into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0000101 ! sulfur amino acid transport +is_a: GO:0015807 ! L-amino acid transport + +[Term] +id: GO:0015812 +name: gamma-aminobutyric acid transport +namespace: biological_process +def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. +subset: gosubset_prok +synonym: "4-aminobutanoate transport" EXACT [] +synonym: "4-aminobutyrate transport" EXACT [] +synonym: "GABA transport" EXACT [] +is_a: GO:0015807 ! L-amino acid transport + +[Term] +id: GO:0015813 +name: L-glutamate transport +namespace: biological_process +def: "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of, within or between cells." [GOC:ai, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "mitochondrial aspartate/glutamate transport" RELATED [] +is_a: GO:0015800 ! acidic amino acid transport + +[Term] +id: GO:0015814 +name: p-aminobenzoyl-glutamate transport +namespace: biological_process +def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015813 ! L-glutamate transport + +[Term] +id: GO:0015816 +name: glycine transport +namespace: biological_process +def: "The directed movement of glycine, aminoethanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015817 +name: histidine transport +namespace: biological_process +def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-histidine transport" NARROW [] +is_a: GO:0015802 ! basic amino acid transport + +[Term] +id: GO:0015818 +name: isoleucine transport +namespace: biological_process +def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-isoleucine transport" NARROW [] +is_a: GO:0015803 ! branched-chain aliphatic amino acid transport +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015819 +name: lysine transport +namespace: biological_process +def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-lysine transport" NARROW [] +is_a: GO:0015802 ! basic amino acid transport + +[Term] +id: GO:0015820 +name: leucine transport +namespace: biological_process +def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-leucine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015821 +name: methionine transport +namespace: biological_process +def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-methionine transport" NARROW [] +is_a: GO:0000101 ! sulfur amino acid transport + +[Term] +id: GO:0015822 +name: ornithine transport +namespace: biological_process +def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-ornithine transport" NARROW [] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015823 +name: phenylalanine transport +namespace: biological_process +def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-phenylalanine transport" NARROW [] +is_a: GO:0015801 ! aromatic amino acid transport + +[Term] +id: GO:0015824 +name: proline transport +namespace: biological_process +def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-proline transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015825 +name: L-serine transport +namespace: biological_process +def: "The directed movement of L-serine, the levorotatory isomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0032329 ! serine transport + +[Term] +id: GO:0015826 +name: threonine transport +namespace: biological_process +def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-threonine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015827 +name: tryptophan transport +namespace: biological_process +def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-tryptophan transport" NARROW [] +is_a: GO:0015801 ! aromatic amino acid transport + +[Term] +id: GO:0015828 +name: tyrosine transport +namespace: biological_process +def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-tyrosine transport" NARROW [] +is_a: GO:0015801 ! aromatic amino acid transport + +[Term] +id: GO:0015829 +name: valine transport +namespace: biological_process +def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "L-valine transport" NARROW [] +is_a: GO:0015803 ! branched-chain aliphatic amino acid transport +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015830 +name: diaminopimelate transport +namespace: biological_process +def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015807 ! L-amino acid transport + +[Term] +id: GO:0015832 +name: holin +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0008565 +consider: GO:0019835 + +[Term] +id: GO:0015833 +name: peptide transport +namespace: biological_process +def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015834 +name: peptidoglycan peptide transport +namespace: biological_process +def: "The directed movement of peptidoglycan peptides into, out of, within or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "murein peptide transport" EXACT [] +synonym: "muropeptide transport" EXACT [] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0015835 +name: peptidoglycan transport +namespace: biological_process +def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "murein transport" EXACT [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015836 +name: lipid-linked peptidoglycan transport +namespace: biological_process +synonym: "lipid-linked murein transport" EXACT [] +is_a: GO:0015835 ! peptidoglycan transport + +[Term] +id: GO:0015837 +name: amine transport +namespace: biological_process +def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of, within or between cells." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "amine/polyamine transport" RELATED [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015838 +name: betaine transport +namespace: biological_process +def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015839 +name: cadaverine transport +namespace: biological_process +def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015840 +name: urea transport +namespace: biological_process +def: "The directed movement into, out of or within the cell of urea, the water-soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:0015841 +name: chromaffin granule amine transport +namespace: biological_process +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015842 +name: synaptic vesicle amine transport +namespace: biological_process +def: "The directed movement of amines into, out of or within synaptic vesicles." [GOC:ai] +is_a: GO:0015837 ! amine transport +is_a: GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:0015843 +name: methylammonium transport +namespace: biological_process +def: "The directed movement of methylammonium into, out of, within or between cells." [GOC:ai] +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015844 +name: monoamine transport +namespace: biological_process +alt_id: GO:0015873 +def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of, within or between cells." [ChEBI:25375, GOC:mah] +subset: gosubset_prok +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015846 +name: polyamine transport +namespace: biological_process +def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of, within or between cells." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015847 +name: putrescine transport +namespace: biological_process +def: "The directed movement of putrescine into, out of, within or between cells. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015846 ! polyamine transport + +[Term] +id: GO:0015848 +name: spermidine transport +namespace: biological_process +def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of, within or between cells." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015846 ! polyamine transport + +[Term] +id: GO:0015849 +name: organic acid transport +namespace: biological_process +def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015850 +name: organic alcohol transport +namespace: biological_process +def: "The directed movement of organic alcohols into, out of, within or between cells. An organic alcohol is any carbon-containing compound containing a hydroxyl group." [GOC:ai] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015851 +name: nucleobase transport +namespace: biological_process +def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0015853 +name: adenine transport +namespace: biological_process +def: "The directed movement of adenine, 6-aminopurine, into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0006863 ! purine transport + +[Term] +id: GO:0015854 +name: guanine transport +namespace: biological_process +def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of, within or between cells." [GOC:go_curators] +is_a: GO:0006863 ! purine transport + +[Term] +id: GO:0015855 +name: pyrimidine transport +namespace: biological_process +def: "The directed movement of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015851 ! nucleobase transport + +[Term] +id: GO:0015856 +name: cytosine transport +namespace: biological_process +def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0015855 ! pyrimidine transport + +[Term] +id: GO:0015857 +name: uracil transport +namespace: biological_process +def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0015855 ! pyrimidine transport + +[Term] +id: GO:0015858 +name: nucleoside transport +namespace: biological_process +def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0015859 +name: intracellular nucleoside transport +namespace: biological_process +def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai] +is_a: GO:0015858 ! nucleoside transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0015860 +name: purine nucleoside transport +namespace: biological_process +def: "The directed movement of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0015861 +name: cytidine transport +namespace: biological_process +def: "The directed movement of cytidine, cytosine riboside, into, out of, within or between cells." [GOC:go_curators] +is_a: GO:0015864 ! pyrimidine nucleoside transport + +[Term] +id: GO:0015862 +name: uridine transport +namespace: biological_process +def: "The directed movement of uridine, uracil riboside, into, out of, within or between cells." [GOC:go_curators] +is_a: GO:0015864 ! pyrimidine nucleoside transport + +[Term] +id: GO:0015863 +name: xanthosine transport +namespace: biological_process +def: "The directed movement of xanthosine, xanthine riboside, into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015860 ! purine nucleoside transport + +[Term] +id: GO:0015864 +name: pyrimidine nucleoside transport +namespace: biological_process +def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells." [GOC:ai] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0015865 +name: purine nucleotide transport +namespace: biological_process +def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0015866 +name: ADP transport +namespace: biological_process +def: "The directed movement of ADP, adenosine diphosphate, into, out of, within or between cells." [GOC:ai] +is_a: GO:0051503 ! adenine nucleotide transport + +[Term] +id: GO:0015867 +name: ATP transport +namespace: biological_process +def: "The directed movement of ATP, adenosine triphosphate, into, out of, within or between cells." [GOC:ai] +is_a: GO:0051503 ! adenine nucleotide transport + +[Term] +id: GO:0015868 +name: purine ribonucleotide transport +namespace: biological_process +def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] +is_a: GO:0015865 ! purine nucleotide transport + +[Term] +id: GO:0015869 +name: DNA-protein complex transport +namespace: biological_process +def: "The directed movement of DNA-protein complexes into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0015870 +name: acetylcholine transport +namespace: biological_process +def: "The directed movement of acetylcholine into, out of, within or between cells. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +is_a: GO:0006836 ! neurotransmitter transport +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015871 +name: choline transport +namespace: biological_process +def: "The directed movement of choline into, out of, within or between cells. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015872 +name: dopamine transport +namespace: biological_process +def: "The directed movement of dopamine into, out of, within or between cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0015874 +name: norepinephrine transport +namespace: biological_process +def: "The directed movement of norepinephrine into, out of, within or between cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "levarterenol transport" EXACT [] +synonym: "noradrenaline transport" EXACT [] +is_a: GO:0009914 ! hormone transport +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0015875 +name: vitamin or cofactor transport +namespace: biological_process +def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of, within or between cells." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +is_obsolete: true +consider: GO:0051180 +consider: GO:0051181 + +[Term] +id: GO:0015876 +name: acetyl-CoA transport +namespace: biological_process +def: "The directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] +is_a: GO:0051182 ! coenzyme transport + +[Term] +id: GO:0015877 +name: biopterin transport +namespace: biological_process +def: "The directed movement of biopterin into, out of, within or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015878 +name: biotin transport +namespace: biological_process +def: "The directed movement of biotin into, out of, within or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] +synonym: "vitamin B7 transport" EXACT [] +synonym: "vitamin H transport" EXACT [] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0015879 +name: carnitine transport +namespace: biological_process +def: "The directed movement of carnitine into, out of, within or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin Bt transport" EXACT [] +is_a: GO:0051180 ! vitamin transport +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015880 +name: coenzyme A transport +namespace: biological_process +def: "The directed movement of coenzyme A into, out of, within or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] +is_a: GO:0051182 ! coenzyme transport + +[Term] +id: GO:0015881 +name: creatine transport +namespace: biological_process +def: "The directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015882 +name: L-ascorbic acid transport +namespace: biological_process +def: "The directed movement of L-ascorbic acid into, out of, within or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:ai] +synonym: "L-ascorbate transport" EXACT [] +synonym: "vitamin C transport" EXACT [] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0015883 +name: FAD transport +namespace: biological_process +def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of, within or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "flavin adenine dinucleotide transport" EXACT [] +synonym: "flavin-adenine dinucleotide transport" EXACT [] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015884 +name: folic acid transport +namespace: biological_process +def: "The directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] +synonym: "folate transport" EXACT [] +synonym: "vitamin B9 transport" EXACT [] +synonym: "vitamin M transport" EXACT [] +is_a: GO:0051180 ! vitamin transport +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015885 +name: 5-formyltetrahydrofolate transport +namespace: biological_process +def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells." [GOC:ai] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015886 +name: heme transport +namespace: biological_process +def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "haem transport" EXACT [] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015887 +name: pantothenate transport +namespace: biological_process +def: "The directed movement of pantothenate into, out of, within or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "vitamin B5 transport" EXACT [] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0015888 +name: thiamin transport +namespace: biological_process +def: "The directed movement of thiamin into, out of, within or between cells. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai] +subset: gosubset_prok +synonym: "thiamine transport" EXACT [] +synonym: "vitamin B1 transport" EXACT [] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0015889 +name: cobalamin transport +namespace: biological_process +def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin B12 transport" EXACT [] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0015890 +name: nicotinamide mononucleotide transport +namespace: biological_process +def: "The directed movement of nicotinamide mononucleotide into, out of, within or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "nicotinamide ribonucleotide transport" EXACT [] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0015891 +name: siderophore transport +namespace: biological_process +def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "siderochrome transport" NARROW [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015892 +name: siderophore-iron transport +namespace: biological_process +def: "The directed movement of iron-siderophores into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "iron-siderochrome transport" NARROW [] +synonym: "iron-siderophore transport" EXACT [] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0015891 ! siderophore transport +relationship: part_of GO:0033214 ! iron assimilation by chelation and transport + +[Term] +id: GO:0015893 +name: drug transport +namespace: biological_process +def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport +relationship: part_of GO:0042493 ! response to drug + +[Term] +id: GO:0015894 +name: acriflavine transport +namespace: biological_process +def: "The directed movement of acriflavine into, out of, within or between cells. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0015893 ! drug transport +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0015895 +name: alkane transport +namespace: biological_process +def: "The directed movement of alkanes into, out of, within or between cells. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015896 +name: nalidixic acid transport +namespace: biological_process +def: "The directed movement of nalidixic acid into, out of, within or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0015893 ! drug transport +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0015897 +name: organomercurial transport +namespace: biological_process +def: "The directed movement of organomercurial compounds into, out of, within or between cells. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015898 +name: amiloride transport +namespace: biological_process +def: "The directed movement amiloride into, out of, within or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015899 +name: aminotriazole transport +namespace: biological_process +def: "The directed movement of aminotriazole into, out of, within or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0045117 ! azole transport + +[Term] +id: GO:0015900 +name: benomyl transport +namespace: biological_process +def: "The directed movement of benomyl into, out of, within or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0015893 ! drug transport +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0015901 +name: cycloheximide transport +namespace: biological_process +def: "The directed movement of cycloheximide into, out of, within or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015902 +name: carbonyl cyanide m-chlorophenylhydrazone transport +namespace: biological_process +def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [http://cancerweb.ncl.ac.uk/] +synonym: "CCCP transport" EXACT [] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015903 +name: fluconazole transport +namespace: biological_process +def: "The directed movement of fluconazole into, out of, within or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0045117 ! azole transport + +[Term] +id: GO:0015904 +name: tetracycline transport +namespace: biological_process +def: "The directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "tetracyclin transport" EXACT [] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015905 +name: bicyclomycin transport +namespace: biological_process +def: "The directed movement of bicyclomycin into, out of, within or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] +subset: gosubset_prok +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0015906 +name: sulfathiazole transport +namespace: biological_process +def: "The directed movement of sulfathiazole into, out of, within or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group." [http://cancerweb.ncl.ac.uk/] +synonym: "sulphathiazole transport" EXACT [] +is_a: GO:0045117 ! azole transport + +[Term] +id: GO:0015908 +name: fatty acid transport +namespace: biological_process +def: "The directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0015909 +name: long-chain fatty acid transport +namespace: biological_process +def: "The directed movement of long-chain fatty acids into, out of, within or between cells. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015908 ! fatty acid transport + +[Term] +id: GO:0015910 +name: peroxisomal long-chain fatty acid import +namespace: biological_process +def: "The directed movement of long-chain fatty acids into a peroxisome." [GOC:ai] +synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015909 ! long-chain fatty acid transport + +[Term] +id: GO:0015911 +name: plasma membrane long-chain fatty acid transport +namespace: biological_process +def: "The directed movement of long-chain fatty acids across the plasma membrane." [GOC:ai] +is_a: GO:0015909 ! long-chain fatty acid transport + +[Term] +id: GO:0015912 +name: short-chain fatty acid transport +namespace: biological_process +def: "The directed movement of short-chain fatty acids into, out of, within or between cells. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015908 ! fatty acid transport + +[Term] +id: GO:0015913 +name: short-chain fatty acid import +namespace: biological_process +def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons." [GOC:ai] +synonym: "short-chain fatty acid uptake" EXACT [] +is_a: GO:0015912 ! short-chain fatty acid transport + +[Term] +id: GO:0015914 +name: phospholipid transport +namespace: biological_process +def: "The directed movement of phospholipids into, out of, within or between cells. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0015915 +name: fatty acyl transport +namespace: biological_process +def: "The directed movement of fatty acyl groups into, out of, within or between cells. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0015916 +name: fatty acyl coenzyme A transport +namespace: biological_process +def: "The directed movement of fatty acyl coenzyme A into, out of, within or between cells. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015915 ! fatty acyl transport + +[Term] +id: GO:0015917 +name: aminophospholipid transport +namespace: biological_process +def: "The directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0015918 +name: sterol transport +namespace: biological_process +def: "The directed movement of sterols into, out of, within or between cells. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0015919 +name: peroxisomal membrane transport +namespace: biological_process +def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai] +is_a: GO:0043574 ! peroxisomal transport + +[Term] +id: GO:0015920 +name: lipopolysaccharide transport +namespace: biological_process +def: "The directed movement of lipopolysaccharides into, out of, within or between cells. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "LPS transport" EXACT [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015921 +name: lipopolysaccharide export +namespace: biological_process +def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "LPS export" EXACT [] +is_a: GO:0015920 ! lipopolysaccharide transport + +[Term] +id: GO:0015922 +name: aspartate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1, EC:1.4.3.16] +subset: gosubset_prok +xref: EC:1.4.3.- +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0015923 +name: mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015924 +name: mannosyl-oligosaccharide mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0015925 +name: galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015926 +name: glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015927 +name: trehalase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015928 +name: fucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015929 +name: hexosaminidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [http://www.onelook.com/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015930 +name: glutamate synthase activity +namespace: molecular_function +def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] +subset: gosubset_prok +xref: EC:1.4.-.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0015931 +name: nucleobase, nucleoside, nucleotide and nucleic acid transport +namespace: biological_process +def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015932 +name: nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0015933 +name: flavin-containing electron transporter +namespace: molecular_function +def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd] +comment: This term was made obsolete because it does not describe a molecular function. +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015934 +name: large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribosomal large subunit" EXACT [] +is_a: GO:0033279 ! ribosomal subunit + +[Term] +id: GO:0015935 +name: small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of a ribosome." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "ribosomal small subunit" EXACT [] +is_a: GO:0033279 ! ribosomal subunit + +[Term] +id: GO:0015936 +name: coenzyme A metabolic process +namespace: biological_process +alt_id: GO:0006763 +def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] +subset: gosubset_prok +synonym: "CoA metabolism" EXACT [] +synonym: "coenzyme A metabolism" EXACT [] +is_a: GO:0006752 ! group transfer coenzyme metabolic process + +[Term] +id: GO:0015937 +name: coenzyme A biosynthetic process +namespace: biological_process +alt_id: GO:0006764 +def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] +subset: gosubset_prok +synonym: "CoA biosynthesis" EXACT [] +synonym: "coenzyme A anabolism" EXACT [] +synonym: "coenzyme A biosynthesis" EXACT [] +synonym: "coenzyme A formation" EXACT [] +synonym: "coenzyme A synthesis" EXACT [] +xref: MetaCyc:COA-PWY +xref: MetaCyc:PANTOSYN-PWY +xref: MetaCyc:PWY-4221 +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0015936 ! coenzyme A metabolic process + +[Term] +id: GO:0015938 +name: coenzyme A catabolic process +namespace: biological_process +alt_id: GO:0006765 +def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] +subset: gosubset_prok +synonym: "CoA catabolism" EXACT [] +synonym: "coenzyme A breakdown" EXACT [] +synonym: "coenzyme A catabolism" EXACT [] +synonym: "coenzyme A degradation" EXACT [] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0015936 ! coenzyme A metabolic process + +[Term] +id: GO:0015939 +name: pantothenate metabolic process +namespace: biological_process +alt_id: GO:0006770 +def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "pantothenate metabolism" EXACT [] +synonym: "vitamin B5 metabolic process" EXACT [] +synonym: "vitamin B5 metabolism" EXACT [] +is_a: GO:0006752 ! group transfer coenzyme metabolic process + +[Term] +id: GO:0015940 +name: pantothenate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "pantothenate anabolism" EXACT [] +synonym: "pantothenate biosynthesis" EXACT [] +synonym: "pantothenate formation" EXACT [] +synonym: "pantothenate synthesis" EXACT [] +synonym: "vitamin B5 biosynthesis" EXACT [] +synonym: "vitamin B5 biosynthetic process" EXACT [] +xref: MetaCyc:PANTOSYN-PWY +xref: MetaCyc:PWY-4221 +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0015939 ! pantothenate metabolic process + +[Term] +id: GO:0015941 +name: pantothenate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "pantothenate breakdown" EXACT [] +synonym: "pantothenate catabolism" EXACT [] +synonym: "pantothenate degradation" EXACT [] +synonym: "vitamin B5 catabolic process" EXACT [] +synonym: "vitamin B5 catabolism" EXACT [] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0015939 ! pantothenate metabolic process + +[Term] +id: GO:0015942 +name: formate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "formate metabolism" EXACT [] +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0015943 +name: formate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "formate anabolism" EXACT [] +synonym: "formate biosynthesis" EXACT [] +synonym: "formate formation" EXACT [] +synonym: "formate synthesis" EXACT [] +synonym: "formic acid biosynthesis" EXACT [] +synonym: "formic acid biosynthetic process" EXACT [] +is_a: GO:0015942 ! formate metabolic process +is_a: GO:0019753 ! one-carbon compound biosynthetic process + +[Term] +id: GO:0015944 +name: formate oxidation +namespace: biological_process +subset: gosubset_prok +synonym: "formic acid oxidation" EXACT [] +is_a: GO:0015942 ! formate metabolic process + +[Term] +id: GO:0015945 +name: methanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methanol metabolism" EXACT [] +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0034308 ! monohydric alcohol metabolic process + +[Term] +id: GO:0015946 +name: methanol oxidation +namespace: biological_process +subset: gosubset_prok +synonym: "carbon dioxide formation from methanol" EXACT [] +xref: MetaCyc:CO2FORM-PWY +is_a: GO:0015945 ! methanol metabolic process + +[Term] +id: GO:0015947 +name: methane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "methane metabolism" EXACT [] +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:0015948 +name: methanogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "methane biosynthesis" EXACT [] +synonym: "methane biosynthetic process" EXACT [] +xref: UM-BBD_pathwayID:meth +is_a: GO:0009061 ! anaerobic respiration +is_a: GO:0015947 ! methane metabolic process +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0019753 ! one-carbon compound biosynthetic process +is_a: GO:0043447 ! alkane biosynthetic process + +[Term] +id: GO:0015949 +name: nucleobase, nucleoside and nucleotide interconversion +namespace: biological_process +subset: goslim_pir +subset: gosubset_prok +xref: MetaCyc:P1-PWY +is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process + +[Term] +id: GO:0015950 +name: purine nucleotide interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion + +[Term] +id: GO:0015951 +name: purine ribonucleotide interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015950 ! purine nucleotide interconversion + +[Term] +id: GO:0015952 +name: purine deoxyribonucleotide interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015950 ! purine nucleotide interconversion + +[Term] +id: GO:0015953 +name: pyrimidine nucleotide interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion + +[Term] +id: GO:0015954 +name: pyrimidine ribonucleotide interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015953 ! pyrimidine nucleotide interconversion + +[Term] +id: GO:0015955 +name: pyrimidine deoxyribonucleotide interconversion +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:DEOXYPYRNUCMET-PWY +is_a: GO:0015953 ! pyrimidine nucleotide interconversion + +[Term] +id: GO:0015956 +name: bis(5'-nucleosidyl) oligophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] +subset: gosubset_prok +synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT [] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0015957 +name: bis(5'-nucleosidyl) oligophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] +subset: gosubset_prok +synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT [] +is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0015958 +name: bis(5'-nucleosidyl) oligophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] +subset: gosubset_prok +synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT [] +is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process + +[Term] +id: GO:0015959 +name: diadenosine polyphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine polyphosphate metabolism" EXACT [] +is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process + +[Term] +id: GO:0015960 +name: diadenosine polyphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine polyphosphate anabolism" EXACT [] +synonym: "diadenosine polyphosphate biosynthesis" EXACT [] +synonym: "diadenosine polyphosphate formation" EXACT [] +synonym: "diadenosine polyphosphate synthesis" EXACT [] +is_a: GO:0015957 ! bis(5'-nucleosidyl) oligophosphate biosynthetic process +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015961 +name: diadenosine polyphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine polyphosphate breakdown" EXACT [] +synonym: "diadenosine polyphosphate catabolism" EXACT [] +synonym: "diadenosine polyphosphate degradation" EXACT [] +is_a: GO:0015958 ! bis(5'-nucleosidyl) oligophosphate catabolic process +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015962 +name: diadenosine triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine triphosphate metabolism" EXACT [] +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015963 +name: diadenosine triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine triphosphate anabolism" EXACT [] +synonym: "diadenosine triphosphate biosynthesis" EXACT [] +synonym: "diadenosine triphosphate formation" EXACT [] +synonym: "diadenosine triphosphate synthesis" EXACT [] +is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process +is_a: GO:0015962 ! diadenosine triphosphate metabolic process + +[Term] +id: GO:0015964 +name: diadenosine triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine triphosphate breakdown" EXACT [] +synonym: "diadenosine triphosphate catabolism" EXACT [] +synonym: "diadenosine triphosphate degradation" EXACT [] +is_a: GO:0015961 ! diadenosine polyphosphate catabolic process +is_a: GO:0015962 ! diadenosine triphosphate metabolic process + +[Term] +id: GO:0015965 +name: diadenosine tetraphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine tetraphosphate metabolism" EXACT [] +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015966 +name: diadenosine tetraphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine tetraphosphate anabolism" EXACT [] +synonym: "diadenosine tetraphosphate biosynthesis" EXACT [] +synonym: "diadenosine tetraphosphate formation" EXACT [] +synonym: "diadenosine tetraphosphate synthesis" EXACT [] +is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process +is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process + +[Term] +id: GO:0015967 +name: diadenosine tetraphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] +subset: gosubset_prok +synonym: "diadenosine tetraphosphate breakdown" EXACT [] +synonym: "diadenosine tetraphosphate catabolism" EXACT [] +synonym: "diadenosine tetraphosphate degradation" EXACT [] +is_a: GO:0015961 ! diadenosine polyphosphate catabolic process +is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process + +[Term] +id: GO:0015968 +name: stringent response +namespace: biological_process +def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471] +subset: gosubset_prok +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0015969 +name: guanosine tetraphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] +subset: gosubset_prok +synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT [] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT [] +synonym: "guanosine tetraphosphate metabolism" EXACT [] +xref: MetaCyc:PPGPPMET-PWY +is_a: GO:0008617 ! guanosine metabolic process + +[Term] +id: GO:0015970 +name: guanosine tetraphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] +subset: gosubset_prok +synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT [] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT [] +synonym: "guanosine tetraphosphate anabolism" EXACT [] +synonym: "guanosine tetraphosphate biosynthesis" EXACT [] +synonym: "guanosine tetraphosphate formation" EXACT [] +synonym: "guanosine tetraphosphate synthesis" EXACT [] +is_a: GO:0015969 ! guanosine tetraphosphate metabolic process +is_a: GO:0046114 ! guanosine biosynthetic process + +[Term] +id: GO:0015971 +name: guanosine tetraphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] +subset: gosubset_prok +synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT [] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT [] +synonym: "guanosine tetraphosphate breakdown" EXACT [] +synonym: "guanosine tetraphosphate catabolism" EXACT [] +synonym: "guanosine tetraphosphate degradation" EXACT [] +is_a: GO:0015969 ! guanosine tetraphosphate metabolic process +is_a: GO:0046115 ! guanosine catabolic process + +[Term] +id: GO:0015972 +name: guanosine pentaphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] +subset: gosubset_prok +synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT [] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT [] +synonym: "guanosine pentaphosphate metabolism" EXACT [] +is_a: GO:0008617 ! guanosine metabolic process + +[Term] +id: GO:0015973 +name: guanosine pentaphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] +subset: gosubset_prok +synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT [] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT [] +synonym: "guanosine pentaphosphate anabolism" EXACT [] +synonym: "guanosine pentaphosphate biosynthesis" EXACT [] +synonym: "guanosine pentaphosphate formation" EXACT [] +synonym: "guanosine pentaphosphate synthesis" EXACT [] +is_a: GO:0015972 ! guanosine pentaphosphate metabolic process +is_a: GO:0046114 ! guanosine biosynthetic process + +[Term] +id: GO:0015974 +name: guanosine pentaphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] +subset: gosubset_prok +synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT [] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT [] +synonym: "guanosine pentaphosphate breakdown" EXACT [] +synonym: "guanosine pentaphosphate catabolism" EXACT [] +synonym: "guanosine pentaphosphate degradation" EXACT [] +is_a: GO:0015972 ! guanosine pentaphosphate metabolic process +is_a: GO:0046115 ! guanosine catabolic process + +[Term] +id: GO:0015975 +name: energy derivation by oxidation of reduced inorganic compounds +namespace: biological_process +subset: gosubset_prok +synonym: "chemolithotrophie" EXACT [] +synonym: "chemolithotrophy" EXACT [] +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0015976 +name: carbon utilization +namespace: biological_process +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0015977 +name: carbon utilization by fixation of carbon dioxide +namespace: biological_process +def: "Any process by which inorganic carbon (usually carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "autotrophic CO2 fixation" EXACT [] +synonym: "autotrophic CO2 fixation pathway" EXACT [] +synonym: "autotrophy" EXACT [] +is_a: GO:0015976 ! carbon utilization + +[Term] +id: GO:0015978 +name: carbon utilization by utilization of organic compounds +namespace: biological_process +subset: gosubset_prok +synonym: "heterotrophy" EXACT [] +is_a: GO:0015976 ! carbon utilization + +[Term] +id: GO:0015979 +name: photosynthesis +namespace: biological_process +def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0015980 +name: energy derivation by oxidation of organic compounds +namespace: biological_process +subset: gosubset_prok +synonym: "chemoorganotrophy" EXACT [] +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0015981 +name: passive proton transport, down the electrochemical gradient +namespace: biological_process +def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363] +comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products. +is_obsolete: true +consider: GO:0015992 + +[Term] +id: GO:0015982 +name: antiport +namespace: biological_process +def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +replaced_by: GO:0015297 + +[Term] +id: GO:0015983 +name: symport +namespace: biological_process +def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +replaced_by: GO:0015293 + +[Term] +id: GO:0015984 +name: uniport +namespace: biological_process +def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +is_obsolete: true +replaced_by: GO:0015292 + +[Term] +id: GO:0015985 +name: energy coupled proton transport, down electrochemical gradient +namespace: biological_process +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah] +subset: gosubset_prok +is_a: GO:0015992 ! proton transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0015986 +name: ATP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] +subset: gosubset_prok +is_a: GO:0006754 ! ATP biosynthetic process +is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient +relationship: part_of GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0015987 +name: GTP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363] +is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient + +[Term] +id: GO:0015988 +name: energy coupled proton transport, against electrochemical gradient +namespace: biological_process +def: "The transport of protons against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah] +subset: gosubset_prok +is_a: GO:0015992 ! proton transport + +[Term] +id: GO:0015989 +name: light-driven proton transport +namespace: biological_process +def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah] +is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient + +[Term] +id: GO:0015990 +name: electron transport coupled proton transport +namespace: biological_process +def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah] +is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient + +[Term] +id: GO:0015991 +name: ATP hydrolysis coupled proton transport +namespace: biological_process +def: "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah] +subset: gosubset_prok +is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient + +[Term] +id: GO:0015992 +name: proton transport +namespace: biological_process +def: "The directed movement of protons (hydrogen ions) into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +synonym: "hydrogen ion transport" EXACT [] +synonym: "passive proton transport, down the electrochemical gradient" NARROW [] +xref: Reactome:166187 +xref: Reactome:167827 +xref: Reactome:211905 +xref: Reactome:212050 +xref: Reactome:221669 +xref: Reactome:221813 +xref: Reactome:230259 +xref: Reactome:230384 +xref: Reactome:238295 +xref: Reactome:238424 +xref: Reactome:274103 +xref: Reactome:274190 +xref: Reactome:280577 +xref: Reactome:280662 +is_a: GO:0006818 ! hydrogen transport +is_a: GO:0015672 ! monovalent inorganic cation transport + +[Term] +id: GO:0015993 +name: molecular hydrogen transport +namespace: biological_process +def: "The directed movement of molecular hydrogen (H2) into, out of, within or between cells." [GOC:jl] +is_a: GO:0006818 ! hydrogen transport + +[Term] +id: GO:0015994 +name: chlorophyll metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] +subset: gosubset_prok +synonym: "chlorophyll metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0015995 +name: chlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl] +subset: gosubset_prok +synonym: "chlorophyll anabolism" EXACT [] +synonym: "chlorophyll biosynthesis" EXACT [] +synonym: "chlorophyll formation" EXACT [] +synonym: "chlorophyll synthesis" EXACT [] +xref: MetaCyc:CHLOROPHYLL-SYN +is_a: GO:0006779 ! porphyrin biosynthetic process +is_a: GO:0015994 ! chlorophyll metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0015996 +name: chlorophyll catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl] +subset: gosubset_prok +synonym: "chlorophyll breakdown" EXACT [] +synonym: "chlorophyll catabolism" EXACT [] +synonym: "chlorophyll degradation" EXACT [] +is_a: GO:0006787 ! porphyrin catabolic process +is_a: GO:0015994 ! chlorophyll metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0015997 +name: ubiquinone biosynthetic process monooxygenase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it incorporates biological process information. +synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT [] +synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT [] +synonym: "ubiquinone anabolism monooxygenase activity" EXACT [] +synonym: "ubiquinone formation monooxygenase activity" EXACT [] +synonym: "ubiquinone synthesis monooxygenase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016002 +name: sulfite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2S + acceptor + 3 H2O = SO3(2-) (sulfite) + reduced acceptor." [EC:1.8.99.1] +subset: gosubset_prok +synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1] +synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1] +synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1] +synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1] +synonym: "sulphite reductase activity" EXACT [] +xref: EC:1.8.99.1 +xref: MetaCyc:SULFITE-REDUCTASE-RXN +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016004 +name: phospholipase activator activity +namespace: molecular_function +def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai] +is_a: GO:0060229 ! lipase activator activity + +[Term] +id: GO:0016005 +name: phospholipase A2 activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai] +is_a: GO:0016004 ! phospholipase activator activity + +[Term] +id: GO:0016006 +name: Nebenkern +namespace: cellular_component +def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] +is_a: GO:0005739 ! mitochondrion + +[Term] +id: GO:0016007 +name: mitochondrial derivative +namespace: cellular_component +def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma] +is_a: GO:0005739 ! mitochondrion + +[Term] +id: GO:0016008 +name: major mitochondrial derivative +namespace: cellular_component +def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504] +is_a: GO:0016007 ! mitochondrial derivative + +[Term] +id: GO:0016009 +name: minor mitochondrial derivative +namespace: cellular_component +def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504] +is_a: GO:0016007 ! mitochondrial derivative + +[Term] +id: GO:0016010 +name: dystrophin-associated glycoprotein complex +namespace: cellular_component +def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609] +subset: goslim_pir +synonym: "DGC" EXACT [] +synonym: "dystrophin glycoprotein complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0016011 +name: dystroglycan complex +namespace: cellular_component +def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex + +[Term] +id: GO:0016012 +name: sarcoglycan complex +namespace: cellular_component +def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] +synonym: "sarcoglycan-sarcospan complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0016011 ! dystroglycan complex + +[Term] +id: GO:0016013 +name: syntrophin complex +namespace: cellular_component +def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn] +is_a: GO:0043234 ! protein complex +relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex + +[Term] +id: GO:0016014 +name: dystrobrevin complex +namespace: cellular_component +def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609] +is_a: GO:0043234 ! protein complex +relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex + +[Term] +id: GO:0016015 +name: morphogen activity +namespace: molecular_function +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0016016 +name: short-wave-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055] +comment: This term was made obsolete because it refers to a class of proteins. +is_obsolete: true +consider: GO:0007603 +consider: GO:0009588 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0016018 +name: cyclosporin A binding +namespace: molecular_function +def: "Interacting selectively with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] +synonym: "cyclophilin" RELATED [] +is_a: GO:0008144 ! drug binding +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0016019 +name: peptidoglycan receptor activity +namespace: molecular_function +def: "Combining with a peptidoglycan to initiate a change in cell activity." [PMID:14698226] +comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. +synonym: "peptidoglycan recognition activity" NARROW [] +is_a: GO:0008329 ! pattern recognition receptor activity +is_a: GO:0042834 ! peptidoglycan binding + +[Term] +id: GO:0016020 +name: membrane +namespace: cellular_component +def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194] +subset: goslim_candida +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0016021 +name: integral to membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators] +subset: gosubset_prok +synonym: "transmembrane" EXACT [] +is_a: GO:0031224 ! intrinsic to membrane + +[Term] +id: GO:0016023 +name: cytoplasmic membrane-bounded vesicle +namespace: cellular_component +def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +subset: gosubset_prok +synonym: "cytoplasmic membrane bounded vesicle" EXACT [] +synonym: "cytoplasmic membrane-enclosed vesicle" EXACT [] +is_a: GO:0031410 ! cytoplasmic vesicle +is_a: GO:0031988 ! membrane-bounded vesicle +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0016024 +name: CDP-diacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "CDP-diacylglycerol anabolism" EXACT [] +synonym: "CDP-diacylglycerol biosynthesis" EXACT [] +synonym: "CDP-diacylglycerol formation" EXACT [] +synonym: "CDP-diacylglycerol synthesis" EXACT [] +is_a: GO:0006651 ! diacylglycerol biosynthetic process +is_a: GO:0046341 ! CDP-diacylglycerol metabolic process + +[Term] +id: GO:0016025 +name: proteasome endopeptidase regulator +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0004175 + +[Term] +id: GO:0016026 +name: proteasome endopeptidase core +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0004175 + +[Term] +id: GO:0016027 +name: inaD signaling complex +namespace: cellular_component +def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [FB:FBrf0105321, GOC:hb, PMID:9010208] +synonym: "inaD signalling complex" EXACT [] +is_a: GO:0019897 ! extrinsic to plasma membrane +is_a: GO:0043234 ! protein complex +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0016028 ! rhabdomere + +[Term] +id: GO:0016028 +name: rhabdomere +namespace: cellular_component +def: "The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, PMID:8646774] +subset: goslim_pir +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0016029 +name: subrhabdomeral cisterna +namespace: cellular_component +def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] +synonym: "SMC" RELATED [] +synonym: "submicrovillar cisterna" EXACT [PMID:11707492] +is_a: GO:0031984 ! organelle subcompartment +is_a: GO:0044432 ! endoplasmic reticulum part +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0005790 ! smooth endoplasmic reticulum +relationship: part_of GO:0016028 ! rhabdomere + +[Term] +id: GO:0016030 +name: metarhodopsin binding +namespace: molecular_function +def: "Interacting selectively with metarhodopsin, a transient intermediate produced upon irradiation of rhodopsin in the visual cycle and existing in two forms, metarhodopsins I and II. The latter dissociates to form opsin and all-trans retinal." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0002046 ! opsin binding + +[Term] +id: GO:0016031 +name: cytoplasmic tRNA import into mitochondrion +namespace: biological_process +def: "The directed movement of cytoplasmic tRNA into a mitochondrion." [GOC:ma, PMID:10988073, PMID:11121736] +synonym: "cytoplasmic tRNA import into mitochondria" EXACT [] +synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT [] +synonym: "cytoplasmic tRNA, mitochondrial import" EXACT [] +synonym: "mitochondrial import of cytoplasmic tRNA" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0051031 ! tRNA transport + +[Term] +id: GO:0016032 +name: viral reproduction +namespace: biological_process +def: "The process by which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:mah] +comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. +subset: goslim_generic +subset: goslim_pir +synonym: "viral infection" RELATED [] +synonym: "viral life cycle" EXACT [] +synonym: "viral replication cycle" EXACT [] +synonym: "virulence" RELATED [] +xref: Reactome:162587 +xref: Reactome:162906 +xref: Reactome:168255 +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0016034 +name: maleylacetoacetate isomerase activity +namespace: molecular_function +alt_id: GO:0018841 +def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2] +subset: gosubset_prok +synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2] +synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2] +synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2] +synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2] +xref: EC:5.2.1.2 +xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN +xref: Reactome:23371 +xref: UM-BBD_enzymeID:e0082 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0016035 +name: zeta DNA polymerase complex +namespace: cellular_component +def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0044446 ! intracellular organelle part + +[Term] +id: GO:0016036 +name: cellular response to phosphate starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0016037 +name: absorption of light +namespace: biological_process +def: "The reception of a photon by a cell." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0016038 +name: absorption of visible light +namespace: biological_process +def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0016037 ! absorption of light + +[Term] +id: GO:0016039 +name: absorption of UV light +namespace: biological_process +def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0016037 ! absorption of light + +[Term] +id: GO:0016040 +name: glutamate synthase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+." [EC:1.4.1.14] +subset: gosubset_prok +synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14] +synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14] +synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14] +synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14] +synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14] +synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14] +synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14] +synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14] +xref: EC:1.4.1.14 +xref: MetaCyc:GLUTAMATE-SYNTHASE-(NADH)-RXN +is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor + +[Term] +id: GO:0016041 +name: glutamate synthase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin." [EC:1.4.7.1] +subset: gosubset_prok +synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1] +synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1] +synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1] +synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1] +xref: EC:1.4.7.1 +xref: MetaCyc:GLUTAMATE-SYNTHASE-(FERREDOXIN)-RXN +xref: MetaCyc:PWY-4341 +is_a: GO:0015930 ! glutamate synthase activity +is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0016042 +name: lipid catabolic process +namespace: biological_process +alt_id: GO:0006724 +def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] +subset: gosubset_prok +synonym: "lipid breakdown" EXACT [] +synonym: "lipid catabolism" EXACT [] +synonym: "lipid degradation" EXACT [] +synonym: "lipolysis" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0009056 ! catabolic process + +[Term] +id: GO:0016043 +name: cellular component organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "cell organisation and biogenesis" EXACT [] +synonym: "cell organization and biogenesis" EXACT [] +synonym: "cellular component biogenesis" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0016044 +name: membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "membrane organisation and biogenesis" EXACT [] +synonym: "membrane organization and biogenesis" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0016045 +name: detection of bacterium +namespace: biological_process +alt_id: GO:0009598 +alt_id: GO:0009681 +def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb] +synonym: "detection of bacteria" EXACT [] +synonym: "perception of bacteria" RELATED [] +synonym: "perception of bacterium" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009617 ! response to bacterium + +[Term] +id: GO:0016046 +name: detection of fungus +namespace: biological_process +alt_id: GO:0009599 +def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb] +synonym: "detection of fungi" EXACT [] +synonym: "perception of fungi" RELATED [] +synonym: "perception of fungus" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009620 ! response to fungus + +[Term] +id: GO:0016047 +name: detection of parasitic fungus +namespace: biological_process +def: "The series of events in which a stimulus from a parasitic fungus (a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection) is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "detection of parasitic fungi" EXACT [] +synonym: "perception of parasitic fungi" RELATED [] +synonym: "perception of parasitic fungus" RELATED [] +is_a: GO:0009603 ! detection of symbiotic fungus +is_a: GO:0009623 ! response to parasitic fungus + +[Term] +id: GO:0016048 +name: detection of temperature stimulus +namespace: biological_process +def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb] +synonym: "detection of temperature" EXACT [] +synonym: "detection of thermal stimulus" EXACT [] +synonym: "perception of temperature" RELATED [] +is_a: GO:0009266 ! response to temperature stimulus +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0016049 +name: cell growth +namespace: biological_process +def: "The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "cell expansion" RELATED [] +synonym: "cellular growth" EXACT [] +synonym: "growth of cell" EXACT [] +synonym: "metabolic process resulting in cell growth" RELATED [] +synonym: "metabolism resulting in cell growth" RELATED [] +is_a: GO:0009987 ! cellular process +is_a: GO:0040007 ! growth +relationship: part_of GO:0008361 ! regulation of cell size + +[Term] +id: GO:0016050 +name: vesicle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] +subset: goslim_pir +synonym: "vesicle organisation and biogenesis" EXACT [] +synonym: "vesicle organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0016051 +name: carbohydrate biosynthetic process +namespace: biological_process +alt_id: GO:0006093 +def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "anabolic carbohydrate metabolic process" EXACT [] +synonym: "anabolic carbohydrate metabolism" EXACT [] +synonym: "carbohydrate anabolism" EXACT [] +synonym: "carbohydrate biosynthesis" EXACT [] +synonym: "carbohydrate formation" EXACT [] +synonym: "carbohydrate synthesis" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0009058 ! biosynthetic process + +[Term] +id: GO:0016052 +name: carbohydrate catabolic process +namespace: biological_process +alt_id: GO:0006095 +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carbohydrate breakdown" EXACT [] +synonym: "carbohydrate catabolism" EXACT [] +synonym: "carbohydrate degradation" EXACT [] +synonym: "catabolic carbohydrate metabolic process" EXACT [] +synonym: "catabolic carbohydrate metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0009056 ! catabolic process + +[Term] +id: GO:0016053 +name: organic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "organic acid anabolism" EXACT [] +synonym: "organic acid biosynthesis" EXACT [] +synonym: "organic acid formation" EXACT [] +synonym: "organic acid synthesis" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0016054 +name: organic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "organic acid breakdown" EXACT [] +synonym: "organic acid catabolism" EXACT [] +synonym: "organic acid degradation" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0016055 +name: Wnt receptor signaling pathway +namespace: biological_process +alt_id: GO:0007222 +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] +synonym: "frizzled signaling pathway" EXACT [] +synonym: "frizzled signalling pathway" EXACT [] +synonym: "Wnt receptor signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0016056 +name: rhodopsin mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon." [GOC:dph, GOC:hb, GOC:tb] +synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0016057 +name: regulation of membrane potential in photoreceptor cell +namespace: biological_process +def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] +synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042391 ! regulation of membrane potential +relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway + +[Term] +id: GO:0016058 +name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling +namespace: biological_process +def: "Maintenance of the excited state of a photoreceptor cell to produce a steady state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] +synonym: "maintenance of rhodopsin mediated signaling" RELATED [] +synonym: "maintenance of rhodopsin mediated signalling" EXACT [] +is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell + +[Term] +id: GO:0016059 +name: deactivation of rhodopsin mediated signaling +namespace: biological_process +def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] +synonym: "deactivation of rhodopsin mediated signalling" EXACT [] +is_a: GO:0022400 ! regulation of rhodopsin mediated signaling +relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction + +[Term] +id: GO:0016060 +name: metarhodopsin inactivation +namespace: biological_process +def: "Process by which metarhodopsin is prevented from generating molecular signals." [GOC:hb] +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling + +[Term] +id: GO:0016061 +name: regulation of light-activated channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0016062 +name: adaptation of rhodopsin mediated signaling +namespace: biological_process +def: "Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] +synonym: "adaptation of rhodopsin mediated signalling" EXACT [] +is_a: GO:0022401 ! adaptation of signaling pathway +relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction + +[Term] +id: GO:0016063 +name: rhodopsin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "rhodopsin anabolism" EXACT [] +synonym: "rhodopsin biosynthesis" EXACT [] +synonym: "rhodopsin formation" EXACT [] +synonym: "rhodopsin synthesis" EXACT [] +is_a: GO:0006726 ! eye pigment biosynthetic process +is_a: GO:0046154 ! rhodopsin metabolic process + +[Term] +id: GO:0016064 +name: immunoglobulin mediated immune response +namespace: biological_process +def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was improved by GO_REF:0000022. It was renamed and redefined. +synonym: "antibody-mediated immune response" EXACT [] +is_a: GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0016065 +name: humoral defense mechanism (sensu Protostomia) +namespace: biological_process +def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jic] +comment: This term was made obsolete because antibodies are not found in the taxon Protostomia. +synonym: "humoral defence mechanism (sensu Protostomia)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016068 +name: type I hypersensitivity +namespace: biological_process +def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity. +synonym: "immediate hypersensitivity response" EXACT [] +is_a: GO:0002524 ! hypersensitivity +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0016070 +name: RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "RNA metabolism" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0034960 ! cellular biopolymer metabolic process + +[Term] +id: GO:0016071 +name: mRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mRNA metabolism" EXACT [] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0016072 +name: rRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "rRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0016073 +name: snRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "snRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0016074 +name: snoRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc] +synonym: "snoRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0016075 +name: rRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai] +subset: gosubset_prok +synonym: "rRNA breakdown" EXACT [] +synonym: "rRNA catabolism" EXACT [] +synonym: "rRNA degradation" EXACT [] +is_a: GO:0016072 ! rRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016076 +name: snRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "snRNA breakdown" EXACT [] +synonym: "snRNA catabolism" EXACT [] +synonym: "snRNA degradation" EXACT [] +is_a: GO:0016073 ! snRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016077 +name: snoRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "snoRNA breakdown" EXACT [] +synonym: "snoRNA catabolism" EXACT [] +synonym: "snoRNA degradation" EXACT [] +is_a: GO:0016074 ! snoRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016078 +name: tRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai] +subset: gosubset_prok +synonym: "tRNA breakdown" EXACT [] +synonym: "tRNA catabolism" EXACT [] +synonym: "tRNA degradation" EXACT [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016079 +name: synaptic vesicle exocytosis +namespace: biological_process +def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jic, GOC:lmg] +is_a: GO:0006887 ! exocytosis +is_a: GO:0048489 ! synaptic vesicle transport +relationship: part_of GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0016080 +name: synaptic vesicle targeting +namespace: biological_process +def: "The process by which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] +is_a: GO:0006903 ! vesicle targeting +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016081 +name: synaptic vesicle docking during exocytosis +namespace: biological_process +def: "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342] +is_a: GO:0006904 ! vesicle docking during exocytosis +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016082 +name: synaptic vesicle priming +namespace: biological_process +def: "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016083 +name: synaptic vesicle fusion +namespace: biological_process +def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016084 +name: myostimulatory hormone activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016085 +name: myoinhibitory hormone activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016086 +name: allatostatin +namespace: molecular_function +def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, http://cancerweb.ncl.ac.uk/, PMID:10891383] +comment: This term was made obsolete because it refers to a gene product. +is_obsolete: true +consider: GO:0005102 +consider: GO:0045968 + +[Term] +id: GO:0016087 +name: ecdysiostatic hormone activity +namespace: molecular_function +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0016088 +name: insulin +namespace: molecular_function +def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005102 +consider: GO:0045722 +consider: GO:0045727 +consider: GO:0045935 +consider: GO:0046326 +consider: GO:0046889 + +[Term] +id: GO:0016090 +name: prenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684] +subset: gosubset_prok +synonym: "prenol metabolism" EXACT [] +is_a: GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0016091 +name: prenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] +subset: gosubset_prok +synonym: "prenol anabolism" EXACT [] +synonym: "prenol biosynthesis" EXACT [] +synonym: "prenol formation" EXACT [] +synonym: "prenol synthesis" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0016090 ! prenol metabolic process + +[Term] +id: GO:0016092 +name: prenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] +subset: gosubset_prok +synonym: "prenol breakdown" EXACT [] +synonym: "prenol catabolism" EXACT [] +synonym: "prenol degradation" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0016090 ! prenol metabolic process + +[Term] +id: GO:0016093 +name: polyprenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [ISBN:0198547684] +subset: gosubset_prok +synonym: "polyprenol metabolism" EXACT [] +is_a: GO:0016090 ! prenol metabolic process + +[Term] +id: GO:0016094 +name: polyprenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators] +subset: gosubset_prok +synonym: "polyprenol anabolism" EXACT [] +synonym: "polyprenol biosynthesis" EXACT [] +synonym: "polyprenol formation" EXACT [] +synonym: "polyprenol synthesis" EXACT [] +is_a: GO:0016091 ! prenol biosynthetic process +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0016095 +name: polyprenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators] +subset: gosubset_prok +synonym: "polyprenol breakdown" EXACT [] +synonym: "polyprenol catabolism" EXACT [] +synonym: "polyprenol degradation" EXACT [] +is_a: GO:0016092 ! prenol catabolic process +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0016098 +name: monoterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409, ISBN:0198547684] +subset: gosubset_prok +synonym: "monoterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016099 +name: monoterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409] +subset: gosubset_prok +synonym: "monoterpenoid anabolism" EXACT [] +synonym: "monoterpenoid biosynthesis" EXACT [] +synonym: "monoterpenoid formation" EXACT [] +synonym: "monoterpenoid synthesis" EXACT [] +xref: MetaCyc:PWY-3041 +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016100 +name: monoterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409] +subset: gosubset_prok +synonym: "monoterpenoid breakdown" EXACT [] +synonym: "monoterpenoid catabolism" EXACT [] +synonym: "monoterpenoid degradation" EXACT [] +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016101 +name: diterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684] +subset: gosubset_prok +synonym: "diterpene metabolic process" NARROW [] +synonym: "diterpene metabolism" NARROW [] +synonym: "diterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016102 +name: diterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "diterpene biosynthesis" NARROW [] +synonym: "diterpene biosynthetic process" NARROW [] +synonym: "diterpenoid anabolism" EXACT [] +synonym: "diterpenoid biosynthesis" EXACT [] +synonym: "diterpenoid formation" EXACT [] +synonym: "diterpenoid synthesis" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016103 +name: diterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] +subset: gosubset_prok +synonym: "diterpene catabolic process" NARROW [] +synonym: "diterpene catabolism" NARROW [] +synonym: "diterpenoid breakdown" EXACT [] +synonym: "diterpenoid catabolism" EXACT [] +synonym: "diterpenoid degradation" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016104 +name: triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "triterpene biosynthesis" NARROW [] +synonym: "triterpene biosynthetic process" NARROW [] +synonym: "triterpenoid anabolism" EXACT [] +synonym: "triterpenoid biosynthesis" EXACT [] +synonym: "triterpenoid formation" EXACT [] +synonym: "triterpenoid synthesis" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016105 +name: triterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "triterpene catabolic process" NARROW [] +synonym: "triterpene catabolism" NARROW [] +synonym: "triterpenoid breakdown" EXACT [] +synonym: "triterpenoid catabolism" EXACT [] +synonym: "triterpenoid degradation" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016106 +name: sesquiterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "sesquiterpenoid anabolism" EXACT [] +synonym: "sesquiterpenoid biosynthesis" EXACT [] +synonym: "sesquiterpenoid formation" EXACT [] +synonym: "sesquiterpenoid synthesis" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0051762 ! sesquiterpene biosynthetic process + +[Term] +id: GO:0016107 +name: sesquiterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "sesquiterpenoid breakdown" EXACT [] +synonym: "sesquiterpenoid catabolism" EXACT [] +synonym: "sesquiterpenoid degradation" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process +is_a: GO:0051763 ! sesquiterpene catabolic process + +[Term] +id: GO:0016108 +name: tetraterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684] +subset: gosubset_prok +synonym: "tetraterpene metabolic process" NARROW [] +synonym: "tetraterpene metabolism" NARROW [] +synonym: "tetraterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016109 +name: tetraterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "tetraterpene biosynthesis" NARROW [] +synonym: "tetraterpene biosynthetic process" NARROW [] +synonym: "tetraterpenoid anabolism" EXACT [] +synonym: "tetraterpenoid biosynthesis" EXACT [] +synonym: "tetraterpenoid formation" EXACT [] +synonym: "tetraterpenoid synthesis" EXACT [] +is_a: GO:0016108 ! tetraterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016110 +name: tetraterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "tetraterpene catabolic process" NARROW [] +synonym: "tetraterpene catabolism" NARROW [] +synonym: "tetraterpenoid breakdown" EXACT [] +synonym: "tetraterpenoid catabolism" EXACT [] +synonym: "tetraterpenoid degradation" EXACT [] +is_a: GO:0016108 ! tetraterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016111 +name: polyterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684] +subset: gosubset_prok +synonym: "polyterpene metabolic process" NARROW [] +synonym: "polyterpene metabolism" NARROW [] +synonym: "polyterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016112 +name: polyterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "polyterpene biosynthesis" NARROW [] +synonym: "polyterpene biosynthetic process" NARROW [] +synonym: "polyterpenoid anabolism" EXACT [] +synonym: "polyterpenoid biosynthesis" EXACT [] +synonym: "polyterpenoid formation" EXACT [] +synonym: "polyterpenoid synthesis" EXACT [] +is_a: GO:0016111 ! polyterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016113 +name: polyterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] +subset: gosubset_prok +synonym: "polyterpene catabolic process" NARROW [] +synonym: "polyterpene catabolism" NARROW [] +synonym: "polyterpenoid breakdown" EXACT [] +synonym: "polyterpenoid catabolism" EXACT [] +synonym: "polyterpenoid degradation" EXACT [] +is_a: GO:0016111 ! polyterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016114 +name: terpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] +subset: gosubset_prok +synonym: "terpenoid anabolism" EXACT [] +synonym: "terpenoid biosynthesis" EXACT [] +synonym: "terpenoid formation" EXACT [] +synonym: "terpenoid synthesis" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process +is_a: GO:0008299 ! isoprenoid biosynthetic process + +[Term] +id: GO:0016115 +name: terpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] +subset: gosubset_prok +synonym: "terpenoid breakdown" EXACT [] +synonym: "terpenoid catabolism" EXACT [] +synonym: "terpenoid degradation" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process +is_a: GO:0008300 ! isoprenoid catabolic process + +[Term] +id: GO:0016116 +name: carotenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] +subset: gosubset_prok +synonym: "carotenoid metabolism" EXACT [] +is_a: GO:0016108 ! tetraterpenoid metabolic process + +[Term] +id: GO:0016117 +name: carotenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] +subset: gosubset_prok +synonym: "carotenoid anabolism" EXACT [] +synonym: "carotenoid biosynthesis" EXACT [] +synonym: "carotenoid formation" EXACT [] +synonym: "carotenoid synthesis" EXACT [] +xref: MetaCyc:CAROTENOID-PWY +is_a: GO:0016109 ! tetraterpenoid biosynthetic process +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0016118 +name: carotenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] +subset: gosubset_prok +synonym: "carotenoid breakdown" EXACT [] +synonym: "carotenoid catabolism" EXACT [] +synonym: "carotenoid degradation" EXACT [] +is_a: GO:0016110 ! tetraterpenoid catabolic process +is_a: GO:0016116 ! carotenoid metabolic process + +[Term] +id: GO:0016119 +name: carotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] +subset: gosubset_prok +synonym: "carotene metabolism" EXACT [] +is_a: GO:0016116 ! carotenoid metabolic process + +[Term] +id: GO:0016120 +name: carotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators] +subset: gosubset_prok +synonym: "carotene anabolism" EXACT [] +synonym: "carotene biosynthesis" EXACT [] +synonym: "carotene formation" EXACT [] +synonym: "carotene synthesis" EXACT [] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:0016121 +name: carotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators] +subset: gosubset_prok +synonym: "carotene breakdown" EXACT [] +synonym: "carotene catabolism" EXACT [] +synonym: "carotene degradation" EXACT [] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:0016122 +name: xanthophyll metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684] +subset: gosubset_prok +synonym: "xanthophyll metabolism" EXACT [] +is_a: GO:0016116 ! carotenoid metabolic process + +[Term] +id: GO:0016123 +name: xanthophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] +subset: gosubset_prok +synonym: "xanthophyll anabolism" EXACT [] +synonym: "xanthophyll biosynthesis" EXACT [] +synonym: "xanthophyll formation" EXACT [] +synonym: "xanthophyll synthesis" EXACT [] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0016124 +name: xanthophyll catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] +subset: gosubset_prok +synonym: "xanthophyll breakdown" EXACT [] +synonym: "xanthophyll catabolism" EXACT [] +synonym: "xanthophyll degradation" EXACT [] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0016125 +name: sterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684] +subset: gosubset_prok +synonym: "sterol metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0016126 +name: sterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] +subset: gosubset_prok +synonym: "sterol anabolism" EXACT [] +synonym: "sterol biosynthesis" EXACT [] +synonym: "sterol formation" EXACT [] +synonym: "sterol synthesis" EXACT [] +xref: MetaCyc:PWY-2541 +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0016125 ! sterol metabolic process + +[Term] +id: GO:0016127 +name: sterol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] +subset: gosubset_prok +synonym: "sterol breakdown" EXACT [] +synonym: "sterol catabolism" EXACT [] +synonym: "sterol degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0016125 ! sterol metabolic process + +[Term] +id: GO:0016128 +name: phytosteroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants differing from animal steroids C1 or C2 residues at C24 and/or a double bond at C22." [ISBN:0198547684] +subset: gosubset_prok +synonym: "phytosteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0016129 +name: phytosteroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids of higher plants differing from animal steroids in having substitutions at C24 and/or a double bond at C22." [GOC:go_curators, ISBN:0471331309 "Biochemical Pathways"] +subset: gosubset_prok +synonym: "phytosteroid anabolism" EXACT [] +synonym: "phytosteroid biosynthesis" EXACT [] +synonym: "phytosteroid formation" EXACT [] +synonym: "phytosteroid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0016128 ! phytosteroid metabolic process + +[Term] +id: GO:0016130 +name: phytosteroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids of higher plants differing from animal steroids C1 or C2 residues at C24 and/or a double bond at C22." [GOC:go_curators] +subset: gosubset_prok +synonym: "phytosteroid breakdown" EXACT [] +synonym: "phytosteroid catabolism" EXACT [] +synonym: "phytosteroid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0016128 ! phytosteroid metabolic process + +[Term] +id: GO:0016131 +name: brassinosteroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] +subset: gosubset_prok +synonym: "brassinosteroid metabolism" EXACT [] +is_a: GO:0016128 ! phytosteroid metabolic process + +[Term] +id: GO:0016132 +name: brassinosteroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] +subset: gosubset_prok +synonym: "brassinosteroid anabolism" EXACT [] +synonym: "brassinosteroid biosynthesis" EXACT [] +synonym: "brassinosteroid formation" EXACT [] +synonym: "brassinosteroid synthesis" EXACT [] +xref: MetaCyc:PWY-2582 +xref: MetaCyc:PWY-699 +is_a: GO:0016129 ! phytosteroid biosynthetic process +is_a: GO:0016131 ! brassinosteroid metabolic process + +[Term] +id: GO:0016133 +name: brassinosteroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] +subset: gosubset_prok +synonym: "brassinosteroid breakdown" EXACT [] +synonym: "brassinosteroid catabolism" EXACT [] +synonym: "brassinosteroid degradation" EXACT [] +is_a: GO:0016130 ! phytosteroid catabolic process +is_a: GO:0016131 ! brassinosteroid metabolic process + +[Term] +id: GO:0016134 +name: saponin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684] +subset: gosubset_prok +synonym: "saponin metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process +is_a: GO:0016128 ! phytosteroid metabolic process +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0016135 +name: saponin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] +subset: gosubset_prok +synonym: "saponin anabolism" EXACT [] +synonym: "saponin biosynthesis" EXACT [] +synonym: "saponin formation" EXACT [] +synonym: "saponin synthesis" EXACT [] +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0016129 ! phytosteroid biosynthetic process +is_a: GO:0016134 ! saponin metabolic process +is_a: GO:0016138 ! glycoside biosynthetic process + +[Term] +id: GO:0016136 +name: saponin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] +subset: gosubset_prok +synonym: "saponin breakdown" EXACT [] +synonym: "saponin catabolism" EXACT [] +synonym: "saponin degradation" EXACT [] +is_a: GO:0016115 ! terpenoid catabolic process +is_a: GO:0016130 ! phytosteroid catabolic process +is_a: GO:0016134 ! saponin metabolic process +is_a: GO:0016139 ! glycoside catabolic process + +[Term] +id: GO:0016137 +name: glycoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684] +subset: gosubset_prok +synonym: "glycoside metabolism" EXACT [] +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0016138 +name: glycoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycoside anabolism" EXACT [] +synonym: "glycoside biosynthesis" EXACT [] +synonym: "glycoside formation" EXACT [] +synonym: "glycoside synthesis" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0016139 +name: glycoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycoside breakdown" EXACT [] +synonym: "glycoside catabolism" EXACT [] +synonym: "glycoside degradation" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0016140 +name: O-glycoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "O-glycoside metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0016141 +name: O-glycoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "O-glycoside anabolism" EXACT [] +synonym: "O-glycoside biosynthesis" EXACT [] +synonym: "O-glycoside formation" EXACT [] +synonym: "O-glycoside synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0016142 +name: O-glycoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "O-glycoside breakdown" EXACT [] +synonym: "O-glycoside catabolism" EXACT [] +synonym: "O-glycoside degradation" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0016143 +name: S-glycoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-glycoside metabolism" EXACT [] +synonym: "thioglycoside metabolic process" EXACT [] +synonym: "thioglycoside metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0016144 +name: S-glycoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-glycoside anabolism" EXACT [] +synonym: "S-glycoside biosynthesis" EXACT [] +synonym: "S-glycoside formation" EXACT [] +synonym: "S-glycoside synthesis" EXACT [] +synonym: "thioglycoside biosynthesis" EXACT [] +synonym: "thioglycoside biosynthetic process" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0016143 ! S-glycoside metabolic process + +[Term] +id: GO:0016145 +name: S-glycoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-glycoside breakdown" EXACT [] +synonym: "S-glycoside catabolism" EXACT [] +synonym: "S-glycoside degradation" EXACT [] +synonym: "thioglycoside catabolic process" EXACT [] +synonym: "thioglycoside catabolism" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0016143 ! S-glycoside metabolic process + +[Term] +id: GO:0016146 +name: protein-synthesizing GTPase activity, initiation +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] +comment: This term was made obsolete because it contains both process and function information. +is_obsolete: true +replaced_by: GO:0003743 +replaced_by: GO:0003924 +replaced_by: GO:0006412 +replaced_by: GO:0006413 + +[Term] +id: GO:0016147 +name: protein-synthesizing GTPase activity, elongation +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] +comment: This term was made obsolete because it contains both process and function information. +is_obsolete: true +replaced_by: GO:0003746 +replaced_by: GO:0003924 +replaced_by: GO:0006412 +replaced_by: GO:0006414 + +[Term] +id: GO:0016148 +name: protein-synthesizing GTPase activity, termination +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] +comment: This term was made obsolete because it contains both process and function information. +is_obsolete: true +replaced_by: GO:0003924 +replaced_by: GO:0006412 +replaced_by: GO:0006415 +replaced_by: GO:0008079 + +[Term] +id: GO:0016149 +name: translation release factor activity, codon specific +namespace: molecular_function +def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0003747 ! translation release factor activity + +[Term] +id: GO:0016150 +name: translation release factor activity, codon nonspecific +namespace: molecular_function +def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684] +comment: Consider also annotating to the molecular function term 'GTP binding ; GO:0005525'. +is_a: GO:0003747 ! translation release factor activity + +[Term] +id: GO:0016151 +name: nickel ion binding +namespace: molecular_function +def: "Interacting selectively with nickel (Ni) ions." [GOC:ai] +subset: gosubset_prok +synonym: "nickel binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0016152 +name: mercury (II) reductase activity +namespace: molecular_function +alt_id: GO:0018692 +def: "Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+." [EC:1.16.1.1] +subset: gosubset_prok +synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1] +synonym: "mer A" RELATED [EC:1.16.1.1] +synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1] +synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1] +synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1] +synonym: "mercury reductase activity" EXACT [EC:1.16.1.1] +synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1] +synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1] +xref: EC:1.16.1.1 +xref: MetaCyc:MERCURY-(II)-REDUCTASE-RXN +xref: UM-BBD_enzymeID:e0056 +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0016153 +name: urocanate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydro-4-oxo-5-imidazolepropanoate = urocanate + H2O." [EC:4.2.1.49] +subset: gosubset_prok +synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49] +synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49] +synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49] +synonym: "urocanase activity" EXACT [EC:4.2.1.49] +xref: EC:4.2.1.49 +xref: MetaCyc:UROCANATE-HYDRATASE-RXN +xref: Reactome:23891 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0016154 +name: pyrimidine-nucleoside phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2] +subset: gosubset_prok +synonym: "Py-NPase activity" EXACT [EC:2.4.2.2] +synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2] +xref: EC:2.4.2.2 +xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0016155 +name: formyltetrahydrofolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+." [EC:1.5.1.6] +synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] +synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] +synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6] +synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] +synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6] +synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] +xref: EC:1.5.1.6 +xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016156 +name: fumarate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate + NAD+ = fumarate + NADH + H+." [EC:1.3.1.6] +subset: gosubset_prok +synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6] +synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6] +synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6] +xref: EC:1.3.1.6 +xref: MetaCyc:FUMARATE-REDUCTASE-(NADH)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016157 +name: sucrose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13] +subset: gosubset_prok +synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13] +synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13] +synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13] +synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13] +synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] +synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] +synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] +xref: EC:2.4.1.13 +xref: MetaCyc:SUCROSE-SYNTHASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0016158 +name: 3-phytase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8] +subset: gosubset_prok +synonym: "1-phytase activity" EXACT [EC:3.1.3.8] +synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8] +synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT [] +synonym: "phytase activity" BROAD [] +synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8] +synonym: "phytate 3-phosphatase activity" EXACT [] +xref: EC:3.1.3.8 +xref: MetaCyc:RXN0-1001 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0016159 +name: muconolactone delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4] +subset: gosubset_prok +synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4] +synonym: "muconolactone D-isomerase activity" EXACT [] +synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4] +xref: EC:5.3.3.4 +xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0016160 +name: amylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai] +subset: gosubset_prok +xref: EC:3.2.1.- +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016161 +name: beta-amylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2] +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2] +synonym: "beta amylase activity" EXACT [EC:3.2.1.2] +synonym: "glycogenase activity" BROAD [EC:3.2.1.2] +synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2] +xref: EC:3.2.1.2 +xref: MetaCyc:3.2.1.2-RXN +is_a: GO:0016160 ! amylase activity + +[Term] +id: GO:0016162 +name: cellulose 1,4-beta-cellobiosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] +subset: gosubset_prok +synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91] +synonym: "avicelase activity" BROAD [EC:3.2.1.91] +synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91] +synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91] +synonym: "CBH 1" RELATED [EC:3.2.1.91] +synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91] +synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91] +synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91] +synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91] +synonym: "exoglucanase activity" EXACT [EC:3.2.1.91] +xref: EC:3.2.1.91 +xref: MetaCyc:3.2.1.91-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016163 +name: nitrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +subset: gosubset_prok +synonym: "iron-iron nitrogenase activity" NARROW [] +synonym: "molybdenum-iron nitrogenase activity" NARROW [] +synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1] +synonym: "vanadium-iron nitrogenase activity" NARROW [] +xref: EC:1.18.6.1 +xref: MetaCyc:NITROGENASE-RXN +xref: UM-BBD_enzymeID:e0395 +is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor + +[Term] +id: GO:0016164 +name: Mo-molybdopterin oxidoreductase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "molybdopterin oxidoreductase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016165 +name: lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12] +subset: gosubset_prok +synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12] +synonym: "fat oxidase activity" EXACT [EC:1.13.11.12] +synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12] +synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12] +synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12] +synonym: "lipoxidase activity" EXACT [EC:1.13.11.12] +synonym: "lipoxydase activity" EXACT [EC:1.13.11.12] +xref: EC:1.13.11.12 +xref: MetaCyc:LIPOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0016166 +name: phytoene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html] +subset: gosubset_prok +xref: EC:1.3.-.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016167 +name: glial cell line-derived neurotrophic factor receptor activity +namespace: molecular_function +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0016168 +name: chlorophyll binding +namespace: molecular_function +def: "Interacting selectively with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] +subset: gosubset_prok +is_a: GO:0046906 ! tetrapyrrole binding + +[Term] +id: GO:0016169 +name: bacteriochlorophyll c binding +namespace: molecular_function +def: "Interacting selectively with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981] +subset: gosubset_prok +is_a: GO:0042314 ! bacteriochlorophyll binding + +[Term] +id: GO:0016170 +name: interleukin-15 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-15 receptor." [GOC:ai] +synonym: "IL-15" NARROW [] +synonym: "interleukin-15 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0016171 +name: cell surface antigen +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true + +[Term] +id: GO:0016172 +name: antifreeze activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl] +comment: This term was made obsolete because it refers to a biological process. +is_obsolete: true +consider: GO:0042309 +consider: GO:0050825 +consider: GO:0050826 + +[Term] +id: GO:0016173 +name: ice nucleation inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai] +comment: This term was made obsolete because it refers to a biological process. +is_obsolete: true +consider: GO:0042309 +consider: GO:0050825 +consider: GO:0050826 + +[Term] +id: GO:0016174 +name: NAD(P)H oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + H2O2." [EC:1.6.3.1] +synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] +synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1] +synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] +synonym: "p138tox" RELATED [EC:1.6.3.1] +synonym: "ThOX activity" NARROW [EC:1.6.3.1] +synonym: "THOX2 activity" NARROW [EC:1.6.3.1] +synonym: "thyroid NADPH oxidase activity" NARROW [] +synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] +synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] +xref: EC:1.6.3.1 +is_a: GO:0050664 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor + +[Term] +id: GO:0016175 +name: superoxide-generating NADPH oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195] +synonym: "cytochrome B-245" RELATED [] +xref: EC:1.6.3.- +is_a: GO:0050664 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor + +[Term] +id: GO:0016176 +name: superoxide-generating NADPH oxidase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai] +synonym: "neutrophil cytosol factor 2" NARROW [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0016180 +name: snRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] +is_a: GO:0016073 ! snRNA metabolic process +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0016182 +name: synaptic vesicle budding from endosome +namespace: biological_process +def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah] +synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah] +is_a: GO:0016197 ! endosome transport +is_a: GO:0070142 ! synaptic vesicle budding +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016183 +name: synaptic vesicle coating +namespace: biological_process +def: "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +is_a: GO:0006901 ! vesicle coating +relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic membrane + +[Term] +id: GO:0016184 +name: synaptic vesicle retrieval +namespace: biological_process +def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016185 +name: synaptic vesicle budding from presynaptic membrane +namespace: biological_process +def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:mah, http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah] +is_a: GO:0070142 ! synaptic vesicle budding +relationship: part_of GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0016186 +name: synaptic vesicle fission +namespace: biological_process +def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016187 +name: synaptic vesicle internalization +namespace: biological_process +def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016188 +name: synaptic vesicle maturation +namespace: biological_process +def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0016189 +name: synaptic vesicle to endosome fusion +namespace: biological_process +def: "Fusion of a synaptic vesicle with the membrane of an endosome." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +synonym: "synaptic vesicle fusion" BROAD [] +is_a: GO:0006944 ! membrane fusion +is_a: GO:0016197 ! endosome transport +is_a: GO:0048284 ! organelle fusion +relationship: part_of GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0016191 +name: synaptic vesicle uncoating +namespace: biological_process +def: "The removal of the protein coat on a synaptic vesicle." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/] +subset: gosubset_prok +synonym: "synaptic vesicle coat depolymerization" EXACT [] +synonym: "synaptic vesicle coat protein depolymerization" EXACT [] +is_a: GO:0051261 ! protein depolymerization +relationship: part_of GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0016192 +name: vesicle-mediated transport +namespace: biological_process +alt_id: GO:0006899 +def: "The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:ai] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "nonselective vesicle transport" NARROW [] +synonym: "protein sorting along secretory pathway" RELATED [] +synonym: "vesicle trafficking" RELATED [] +synonym: "vesicle transport" EXACT [] +is_a: GO:0006810 ! transport +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0016197 +name: endosome transport +namespace: biological_process +def: "The directed movement of substances into, out of or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0016198 +name: axon choice point recognition +namespace: biological_process +def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] +is_a: GO:0008038 ! neuron recognition +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:0016199 +name: axon midline choice point recognition +namespace: biological_process +def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] +is_a: GO:0016198 ! axon choice point recognition + +[Term] +id: GO:0016200 +name: synaptic target attraction +namespace: biological_process +def: "The process by which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0008039 ! synaptic target recognition + +[Term] +id: GO:0016201 +name: synaptic target inhibition +namespace: biological_process +def: "The process by which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0008039 ! synaptic target recognition + +[Term] +id: GO:0016202 +name: regulation of striated muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] +is_a: GO:0048634 ! regulation of muscle development +relationship: regulates GO:0014706 ! striated muscle development + +[Term] +id: GO:0016203 +name: muscle attachment +namespace: biological_process +def: "The developmental process by which a skeletal muscle attaches to a bone." [GOC:isa_complete] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0016204 +name: determination of muscle attachment site +namespace: biological_process +def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0016203 ! muscle attachment + +[Term] +id: GO:0016205 +name: selenocysteine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.-, PMID:10026151] +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0016206 +name: catechol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6] +subset: gosubset_prok +synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6] +synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6] +synonym: "COMT I" RELATED [EC:2.1.1.6] +synonym: "COMT II" RELATED [EC:2.1.1.6] +synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] +synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6] +synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] +xref: EC:2.1.1.6 +xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN +xref: Reactome:24294 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016207 +name: 4-coumarate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12] +subset: gosubset_prok +synonym: "4-coumarate-CoA synthetase activity" EXACT [] +synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12] +synonym: "4-coumarate:CoA ligase activity" EXACT [] +synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12] +synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12] +synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12] +synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] +synonym: "4CL" RELATED [EC:6.2.1.12] +synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] +synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12] +synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] +synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12] +synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12] +synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12] +synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] +synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12] +synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] +synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12] +synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] +synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] +xref: EC:6.2.1.12 +xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0016208 +name: AMP binding +namespace: molecular_function +def: "Interacting selectively with AMP, adenosine monophosphate." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0032559 ! adenyl ribonucleotide binding + +[Term] +id: GO:0016209 +name: antioxidant activity +namespace: molecular_function +def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0016210 +name: naringenin-chalcone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74] +subset: gosubset_prok +synonym: "chalcone synthase activity" EXACT [EC:2.3.1.74] +synonym: "chalcone synthetase activity" EXACT [] +synonym: "CHS" EXACT [] +synonym: "DOCS" NARROW [] +synonym: "flavanone synthase activity" EXACT [EC:2.3.1.74] +synonym: "flavonone synthase activity" EXACT [EC:2.3.1.74] +synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74] +xref: EC:2.3.1.74 +xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0016211 +name: ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +xref: EC:6.3.1.- +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0016212 +name: kynurenine-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7] +subset: gosubset_prok +synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7] +synonym: "kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] +synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7] +synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] +synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT [] +synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] +synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] +xref: EC:2.6.1.7 +xref: MetaCyc:2.6.1.7-RXN +xref: Reactome:24302 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0016213 +name: linoleoyl-CoA desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3] +comment: Note that this function was formerly EC:1.14.99.25. +subset: gosubset_prok +synonym: "delta(6)-acyl CoA desaturase activity" BROAD [] +synonym: "delta(6)-desaturase activity" BROAD [] +synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD [] +synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3] +synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3] +synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3] +synonym: "fatty acid 6-desaturase activity" BROAD [] +synonym: "fatty acid delta(6)-desaturase activity" BROAD [] +synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] +synonym: "linoleate desaturase activity" RELATED [] +synonym: "linoleic acid desaturase activity" RELATED [] +synonym: "linoleic desaturase activity" RELATED [] +synonym: "linoleoyl CoA desaturase activity" EXACT [] +synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3] +synonym: "linoleoyl-coenzyme A desaturase activity" EXACT [] +synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD [] +synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] +xref: EC:1.14.19.3 +xref: MetaCyc:1.14.19.3-RXN +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0016215 +name: CoA desaturase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:1.14.99.- +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016216 +name: isopenicillin-N synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine = isopenicillin-N + H2O." [EC:1.21.3.1, PMID:12926272] +subset: gosubset_prok +synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1] +synonym: "isopenicillin-N synthetase activity" EXACT [] +synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1] +xref: EC:1.21.3.1 +xref: MetaCyc:1.21.3.1-RXN +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0016217 +name: N-ethylammeline chlorohydrolase activity +namespace: molecular_function +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016218 +name: polyketide synthase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016219 +name: GDP-dissociation stimulator activity +namespace: molecular_function +synonym: "GDS" EXACT [] +is_a: GO:0005083 ! small GTPase regulator activity + +[Term] +id: GO:0016220 +name: RAL GDP-dissociation stimulator activity +namespace: molecular_function +is_a: GO:0016219 ! GDP-dissociation stimulator activity + +[Term] +id: GO:0016222 +name: procollagen-proline, 2-oxoglutarate-4-dioxygenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate." [EC:1.14.11.2] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0016223 +name: beta-alanine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18] +subset: gosubset_prok +synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] +synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18] +synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT [] +synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18] +synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] +xref: EC:2.6.1.18 +xref: MetaCyc:2.6.1.18-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0016226 +name: iron-sulfur cluster assembly +namespace: biological_process +def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] +subset: gosubset_prok +synonym: "iron-sulfur cluster biosynthesis" EXACT [] +synonym: "iron-sulphur cluster assembly" EXACT [] +is_a: GO:0031163 ! metallo-sulfur cluster assembly + +[Term] +id: GO:0016227 +name: tRNA sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4] +synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4] +synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] +synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] +synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] +synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] +synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4] +synonym: "tRNA sulphurtransferase activity" EXACT [] +xref: EC:2.8.1.4 +xref: MetaCyc:TRNA-SULFURTRANSFERASE-RXN +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0016229 +name: steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah] +subset: gosubset_prok +xref: EC:1.1.1.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016230 +name: sphingomyelin phosphodiesterase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai] +synonym: "neutral sphingomyelinase activator" EXACT [] +is_a: GO:0016004 ! phospholipase activator activity + +[Term] +id: GO:0016231 +name: beta-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN] +is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity + +[Term] +id: GO:0016232 +name: HNK-1 sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R)." [PMID:9478973] +synonym: "HNK-1 sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0016233 +name: telomere capping +namespace: biological_process +def: "A process by which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] +synonym: "telomere end protection" EXACT [] +xref: Reactome:176700 +xref: Reactome:181450 +xref: Reactome:209099 +xref: Reactome:209101 +xref: Reactome:218823 +xref: Reactome:218825 +is_a: GO:0000723 ! telomere maintenance + +[Term] +id: GO:0016234 +name: inclusion body +namespace: cellular_component +def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0016235 +name: aggresome +namespace: cellular_component +def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0016236 +name: macroautophagy +namespace: biological_process +alt_id: GO:0034262 +def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:9412464] +synonym: "autophagy in response to cellular starvation" EXACT [] +synonym: "non-specific autophagy" EXACT [] +is_a: GO:0006914 ! autophagy +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0016237 +name: microautophagy +namespace: biological_process +def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964] +is_a: GO:0006914 ! autophagy +is_a: GO:0010324 ! membrane invagination + +[Term] +id: GO:0016238 +name: chaperone-mediated autophagy +namespace: biological_process +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0016239 +name: positive regulation of macroautophagy +namespace: biological_process +def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] +synonym: "activation of macroautophagy" NARROW [] +synonym: "stimulation of macroautophagy" NARROW [] +synonym: "up regulation of macroautophagy" EXACT [] +synonym: "up-regulation of macroautophagy" EXACT [] +synonym: "upregulation of macroautophagy" EXACT [] +is_a: GO:0010508 ! positive regulation of autophagy +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0016241 ! regulation of macroautophagy +is_a: GO:0032109 ! positive regulation of response to nutrient levels +relationship: positively_regulates GO:0016236 ! macroautophagy + +[Term] +id: GO:0016240 +name: autophagic vacuole docking +namespace: biological_process +is_a: GO:0022406 ! membrane docking +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0016241 +name: regulation of macroautophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: regulates GO:0016236 ! macroautophagy + +[Term] +id: GO:0016242 +name: negative regulation of macroautophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] +synonym: "down regulation of macroautophagy" EXACT [] +synonym: "down-regulation of macroautophagy" EXACT [] +synonym: "downregulation of macroautophagy" EXACT [] +synonym: "inhibition of macroautophagy" NARROW [] +is_a: GO:0010507 ! negative regulation of autophagy +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0016241 ! regulation of macroautophagy +is_a: GO:0032108 ! negative regulation of response to nutrient levels +relationship: negatively_regulates GO:0016236 ! macroautophagy + +[Term] +id: GO:0016243 +name: regulation of autophagic vacuole size +namespace: biological_process +def: "Any process that modulates the size of the autophagic vacuole." [GOC:krc] +is_a: GO:0032535 ! regulation of cellular component size +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0016244 +name: non-apoptotic programmed cell death +namespace: biological_process +def: "Cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis." [GOC:go_curators] +synonym: "nonapoptotic programmed cell death" EXACT [] +synonym: "type II programmed cell death" EXACT [] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0016245 +name: hyperphosphorylation of RNA polymerase II +namespace: biological_process +def: "The production of an RNA polymerase II enzyme where the C-Terminal Domain (CTD) of the largest subunit is extensively phosphorylated, as a result of activation of kinases, deactivation of phosphatases, or both. This phosphorylation occurs during the initiation phase and is required for the transition to the elongation phase. Specific types of phosphorylation within the CTD are associated with recruitment of complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, PMID:15964991] +synonym: "CTD domain phosphorylation of RNA polymerase II" NARROW [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0048151 ! hyperphosphorylation +relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0016246 +name: RNA interference +namespace: biological_process +def: "The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190] +synonym: "RNAi" EXACT [] +is_a: GO:0035194 ! posttranscriptional gene silencing by RNA + +[Term] +id: GO:0016247 +name: channel regulator activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0015457 ! auxiliary transport protein activity + +[Term] +id: GO:0016248 +name: channel inhibitor activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016247 ! channel regulator activity + +[Term] +id: GO:0016249 +name: channel localizer activity +namespace: molecular_function +def: "Functions to locate the position of ion channels in the cell." [PMID:10218120] +is_a: GO:0015457 ! auxiliary transport protein activity + +[Term] +id: GO:0016250 +name: N-sulfoglucosamine sulfohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + SO4(2-) (sulfate)." [EC:3.10.1.1] +synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1] +synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1] +synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1] +synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT [] +synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1] +synonym: "sulphamidase activity" EXACT [EC:3.10.1.1] +xref: EC:3.10.1.1 +xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN +is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds + +[Term] +id: GO:0016251 +name: general RNA polymerase II transcription factor activity +namespace: molecular_function +alt_id: GO:0003703 +def: "Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF)." [PMID:10384286, PMID:9774831] +is_a: GO:0003702 ! RNA polymerase II transcription factor activity + +[Term] +id: GO:0016252 +name: nonspecific RNA polymerase II transcription factor activity +namespace: molecular_function +def: "Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl] +is_a: GO:0003702 ! RNA polymerase II transcription factor activity + +[Term] +id: GO:0016253 +name: UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + peptide = UDP + N-acetyl-beta-D-glucosaminyl-peptide." [UniProtKB:O15294] +xref: EC:2.4.1.- +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0016254 +name: preassembly of GPI anchor in ER membrane +namespace: biological_process +def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595] +subset: gosubset_prok +synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT [] +xref: Reactome:162710 +xref: Reactome:211535 +xref: Reactome:221312 +xref: Reactome:229952 +xref: Reactome:237969 +xref: Reactome:244594 +xref: Reactome:249531 +xref: Reactome:252344 +xref: Reactome:255506 +xref: Reactome:258871 +xref: Reactome:262254 +xref: Reactome:268220 +xref: Reactome:273904 +xref: Reactome:280383 +xref: Reactome:282744 +xref: Reactome:286400 +xref: Reactome:288200 +is_a: GO:0006650 ! glycerophospholipid metabolic process +relationship: part_of GO:0006506 ! GPI anchor biosynthetic process + +[Term] +id: GO:0016255 +name: attachment of GPI anchor to protein +namespace: biological_process +def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] +subset: gosubset_prok +xref: Reactome:162791 +xref: Reactome:211939 +xref: Reactome:221703 +xref: Reactome:238325 +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0006506 ! GPI anchor biosynthetic process + +[Term] +id: GO:0016256 +name: N-glycan processing to lysosome +namespace: biological_process +def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595] +is_a: GO:0006491 ! N-glycan processing +relationship: part_of GO:0006622 ! protein targeting to lysosome + +[Term] +id: GO:0016257 +name: N-glycan processing to secreted and cell-surface N-glycans +namespace: biological_process +def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595] +subset: gosubset_prok +is_a: GO:0006491 ! N-glycan processing + +[Term] +id: GO:0016258 +name: N-glycan diversification +namespace: biological_process +def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595] +subset: gosubset_prok +is_a: GO:0006491 ! N-glycan processing + +[Term] +id: GO:0016259 +name: selenocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "selenocysteine metabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0016260 +name: selenocysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "selenocysteine anabolism" EXACT [] +synonym: "selenocysteine biosynthesis" EXACT [] +synonym: "selenocysteine formation" EXACT [] +synonym: "selenocysteine synthesis" EXACT [] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process +is_a: GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:0016261 +name: selenocysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "selenocysteine breakdown" EXACT [] +synonym: "selenocysteine catabolism" EXACT [] +synonym: "selenocysteine degradation" EXACT [] +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process +is_a: GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:0016262 +name: protein N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94] +synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94] +synonym: "O-GlcNAc transferase activity" EXACT [] +synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT [] +synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] +xref: EC:2.4.1.94 +xref: MetaCyc:2.4.1.94-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0016263 +name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma] +synonym: "Core 1 GalT" RELATED [] +synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] +synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] +synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122] +xref: EC:2.4.1.122 +xref: MetaCyc:2.4.1.122-RXN +is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity + +[Term] +id: GO:0016264 +name: gap junction assembly +namespace: biological_process +def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jic, ISBN:0716731363] +is_a: GO:0007043 ! cell-cell junction assembly + +[Term] +id: GO:0016265 +name: death +namespace: biological_process +def: "A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, ISBN:0877797099] +comment: See also the biological process term 'apoptosis ; GO:0006915'. +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0016266 +name: O-glycan processing +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form a core O-glycan structure." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0006493 ! protein amino acid O-linked glycosylation + +[Term] +id: GO:0016267 +name: O-glycan processing, core 1 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-1->3-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016268 +name: O-glycan processing, core 2 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-1->6(Gal-beta-1->3)-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016269 +name: O-glycan processing, core 3 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-1->3-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016270 +name: O-glycan processing, core 4 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-1->6(GlcNAc-beta-1->3)-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016271 +name: tissue death +namespace: biological_process +def: "A permanent cessation of all vital functions of a tissue." [GOC:dph] +is_a: GO:0016265 ! death + +[Term] +id: GO:0016272 +name: prefoldin complex +namespace: cellular_component +def: "A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, UniProtKB:O15212] +subset: gosubset_prok +synonym: "GIM complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0016273 +name: arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah] +xref: EC:2.1.1.- +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016274 +name: protein-arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue in a protein substrate." [GOC:mah, PMID:12351636] +synonym: "PRMT activity" EXACT [] +xref: EC:2.1.1.- +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0016273 ! arginine N-methyltransferase activity + +[Term] +id: GO:0016275 +name: [cytochrome c]-arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma] +synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124] +synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124] +synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] +xref: EC:2.1.1.124 +xref: MetaCyc:2.1.1.124-RXN +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0016277 +name: [myelin basic protein]-arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126] +synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126] +synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126] +synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126] +synonym: "protein methylase I activity" BROAD [EC:2.1.1.126] +synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126] +synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126] +xref: EC:2.1.1.126 +xref: MetaCyc:2.1.1.126-RXN +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0016278 +name: lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016279 +name: protein-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0016278 ! lysine N-methyltransferase activity + +[Term] +id: GO:0016281 +name: eukaryotic translation initiation factor 4F complex +namespace: cellular_component +def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, UniProtKB:P41110] +synonym: "eIF-4F" EXACT [] +synonym: "eukaryotic translation initiation factor 4 complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0016282 +name: eukaryotic 43S preinitiation complex +namespace: cellular_component +def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] +synonym: "eukaryotic 43S pre-initiation complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0016284 +name: alanine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +subset: gosubset_prok +xref: EC:3.4.11.- +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0016285 +name: cytosol alanyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] +comment: This term was made obsolete because it represents a gene product and refers to cellular component information. +subset: gosubset_prok +synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14] +synonym: "arylamidase activity" NARROW [EC:3.4.11.14] +synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14] +synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14] +synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14] +synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14] +synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14] +synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14] +xref: EC:3.4.11.14 +xref: MetaCyc:3.4.11.14-RXN +is_obsolete: true +replaced_by: GO:0004177 +replaced_by: GO:0008235 + +[Term] +id: GO:0016286 +name: small conductance calcium-activated potassium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] +synonym: "SK calcium-activated potassium channel activity " EXACT [] +synonym: "SK KCa channels" EXACT [] +synonym: "small conductance KCa channels " EXACT [] +is_a: GO:0015269 ! calcium-activated potassium channel activity + +[Term] +id: GO:0016287 +name: glycerone-phosphate O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate." [EC:2.3.1.42] +synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42] +synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42] +xref: EC:2.3.1.42 +xref: MetaCyc:2.3.1.42-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0016289 +name: CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai] +subset: gosubset_prok +xref: EC:3.1.2.- +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0016290 +name: palmitoyl-CoA hydrolase activity +namespace: molecular_function +alt_id: GO:0016293 +def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] +subset: gosubset_prok +synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] +synonym: "long-chain fatty-acyl-CoA hydrolase activity" EXACT [] +synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2] +synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2] +synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2] +synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2] +synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] +synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2] +xref: EC:3.1.2.2 +xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN +xref: MetaCyc:PWY-5148 +is_a: GO:0016291 ! acyl-CoA thioesterase activity + +[Term] +id: GO:0016291 +name: acyl-CoA thioesterase activity +namespace: molecular_function +alt_id: GO:0008778 +alt_id: GO:0016292 +def: "Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA." [PMID:14660652] +subset: gosubset_prok +synonym: "acyl-CoA thioesterase I activity" NARROW [] +synonym: "acyl-CoA thioesterase II activity" NARROW [] +synonym: "acyl-CoA thiolesterase activity" EXACT [] +xref: EC:3.1.2.- +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0016295 +name: myristoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14] +synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "myristoyl-ACP hydrolase activity" EXACT [] +synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT [] +synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0016296 +name: palmitoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14] +synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "palmitoyl-ACP hydrolase activity" EXACT [] +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0016297 +name: acyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +alt_id: GO:0010281 +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + organic acid." [EC:3.1.2.14] +subset: gosubset_prok +synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "acyl-ACP hydrolase activity" EXACT [] +synonym: "acyl-ACP thioesterase activity" EXACT [] +synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14] +synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14] +synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14] +synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14] +is_a: GO:0004312 ! fatty-acid synthase activity +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0016298 +name: lipase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] +subset: gosubset_prok +xref: EC:3.1.1.- +xref: Reactome:1913 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0016299 +name: regulator of G-protein signaling activity +namespace: molecular_function +def: "Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [UniProtKB:O08774] +synonym: "regulator of G protein signaling activity" EXACT [] +synonym: "regulator of G protein signalling activity" EXACT [] +synonym: "regulator of G-protein signalling activity" EXACT [] +synonym: "RGS" EXACT [] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0016300 +name: tRNA (uracil) methyltransferase activity +namespace: molecular_function +alt_id: GO:0016431 +def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah] +comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). +subset: gosubset_prok +synonym: "tRNA (uridine) methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +is_a: GO:0008175 ! tRNA methyltransferase activity + +[Term] +id: GO:0016301 +name: kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +synonym: "phosphokinase activity" EXACT [] +xref: Reactome:1423 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016303 +name: 1-phosphatidylinositol-3-kinase activity +namespace: molecular_function +alt_id: GO:0004429 +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137, PMID:9759495] +synonym: "1-phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137] +synonym: "phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW [] +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] +synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137] +synonym: "PI3K" EXACT [] +synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137] +synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137] +synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137] +synonym: "Vps34p" RELATED [EC:2.7.1.137] +xref: EC:2.7.1.137 +xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN +is_a: GO:0035004 ! phosphoinositide 3-kinase activity + +[Term] +id: GO:0016304 +name: phosphatidylinositol 3-kinase activity, class I +namespace: molecular_function +def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0016303 +replaced_by: GO:0035005 +replaced_by: GO:0046934 + +[Term] +id: GO:0016305 +name: phosphatidylinositol 3-kinase activity, class II +namespace: molecular_function +def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "PI3KC2" EXACT [] +is_obsolete: true +consider: GO:0016303 +consider: GO:0035005 +consider: GO:0046934 + +[Term] +id: GO:0016306 +name: phosphatidylinositol 3-kinase activity, class III +namespace: molecular_function +def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +replaced_by: GO:0016303 + +[Term] +id: GO:0016307 +name: phosphatidylinositol phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] +subset: gosubset_prok +xref: EC:2.7.1.- +is_a: GO:0001727 ! lipid kinase activity +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0016308 +name: 1-phosphatidylinositol-4-phosphate 5-kinase activity +namespace: molecular_function +alt_id: GO:0004431 +alt_id: GO:0045215 +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.68] +subset: gosubset_prok +synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD [] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW [] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68] +synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68] +synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68] +synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68] +synonym: "PIP kinase activity" BROAD [EC:2.7.1.68] +synonym: "PIP5K" EXACT [] +synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68] +synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68] +xref: EC:2.7.1.68 +xref: MetaCyc:2.7.1.68-RXN +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0016309 +name: 1-phosphatidylinositol-5-phosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149] +synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149] +synonym: "PIP4K" EXACT [] +synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149] +xref: EC:2.7.1.149 +xref: MetaCyc:2.7.1.149-RXN +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0016310 +name: phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006796 ! phosphate metabolic process + +[Term] +id: GO:0016311 +name: dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006796 ! phosphate metabolic process + +[Term] +id: GO:0016312 +name: inositol bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of one of the two phosphate groups of an inositol bisphosphate." [GOC:hb] +xref: EC:3.1.3.- +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0016313 +name: inositol-1,4,5-trisphosphate phosphatase +namespace: molecular_function +def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb] +comment: This term was made obsolete because it is a redundant grouping term with only one child. +is_obsolete: true +consider: GO:0046030 + +[Term] +id: GO:0016314 +name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67] +synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] +synonym: "MMAC1" RELATED [EC:3.1.3.67] +synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] +xref: EC:3.1.3.67 +xref: MetaCyc:3.1.3.67-RXN +xref: Reactome:24758 +is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0016316 +name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity +namespace: molecular_function +alt_id: GO:0004440 +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb] +synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] +synonym: "D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] +synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] +synonym: "inositol-1,4,-bisphosphate 4-phosphatase activity" EXACT [] +synonym: "inositol-3,4-bisphosphate 4-phosphatase activity" EXACT [] +xref: EC:3.1.3.66 +xref: MetaCyc:3.1.3.66-RXN +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity +is_a: GO:0034596 ! phosphoinositide 4-phosphatase activity +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0016318 +name: ommatidial rotation +namespace: biological_process +def: "The process by which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0042067 ! establishment of ommatidial polarity + +[Term] +id: GO:0016319 +name: mushroom body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0016320 +name: endoplasmic reticulum membrane fusion +namespace: biological_process +def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jic] +synonym: "ER membrane fusion" EXACT [] +is_a: GO:0006944 ! membrane fusion +is_a: GO:0048284 ! organelle fusion + +[Term] +id: GO:0016321 +name: female meiosis chromosome segregation +namespace: biological_process +def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0045132 ! meiotic chromosome segregation +relationship: part_of GO:0007143 ! female meiosis + +[Term] +id: GO:0016322 +name: neuron remodeling +namespace: biological_process +def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] +synonym: "neuronal remodeling" EXACT [] +is_a: GO:0042551 ! neuron maturation + +[Term] +id: GO:0016323 +name: basolateral plasma membrane +namespace: cellular_component +def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0016324 +name: apical plasma membrane +namespace: cellular_component +def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0016325 +name: oocyte microtubule cytoskeleton organization +namespace: biological_process +alt_id: GO:0048130 +def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte." [GOC:mtg_sensu, PMID:11231123] +synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] +synonym: "oocyte microtubule cytoskeleton organisation (sensu Insecta)" EXACT [] +synonym: "oocyte microtubule cytoskeleton organization (sensu Insecta)" EXACT [] +is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity +relationship: part_of GO:0007308 ! oocyte construction + +[Term] +id: GO:0016326 +name: kinesin motor activity +namespace: molecular_function +def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0003777 + +[Term] +id: GO:0016327 +name: apicolateral plasma membrane +namespace: cellular_component +def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] +subset: gosubset_prok +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0016328 +name: lateral plasma membrane +namespace: cellular_component +def: "The membranes on the sides of epithelial cells which lie at the interface of adjacent cells." [GOC:hb] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0016329 +name: apoptosis regulator activity +namespace: molecular_function +def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl] +comment: This term was made obsolete because it represents involvement in a biological process. +is_obsolete: true +replaced_by: GO:0042981 + +[Term] +id: GO:0016330 +name: second mitotic wave during compound eye morphogenesis +namespace: biological_process +def: "A discrete cell cycle that occurs during the third instar eye imaginal disc after progression of the morphogenetic furrow. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] +synonym: "second mitotic wave (sensu Endopterygota)" EXACT [] +is_a: GO:0007049 ! cell cycle +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0016331 +name: morphogenesis of embryonic epithelium +namespace: biological_process +def: "The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0016332 +name: establishment or maintenance of polarity of embryonic epithelium +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium + +[Term] +id: GO:0016333 +name: morphogenesis of follicular epithelium +namespace: biological_process +def: "The process by which the anatomical structures of a follicular epithelium are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0016334 +name: establishment or maintenance of polarity of follicular epithelium +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium + +[Term] +id: GO:0016335 +name: morphogenesis of larval imaginal disc epithelium +namespace: biological_process +def: "The process by which the anatomical structures of a larval imaginal disc epithelium are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0002168 ! instar larval development +relationship: part_of GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0016336 +name: establishment or maintenance of polarity of larval imaginal disc epithelium +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium + +[Term] +id: GO:0016337 +name: cell-cell adhesion +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules." [GOC:hb] +subset: gosubset_prok +is_a: GO:0007155 ! cell adhesion + +[Term] +id: GO:0016338 +name: calcium-independent cell-cell adhesion +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] +synonym: "calcium-independent cell adhesion molecule activity" RELATED [] +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0016339 +name: calcium-dependent cell-cell adhesion +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] +synonym: "calcium-dependent cell adhesion molecule activity" RELATED [] +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0016340 +name: calcium-dependent cell-matrix adhesion +namespace: biological_process +def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0016341 +name: other collagen +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a redundant grouping term. +is_obsolete: true +replaced_by: GO:0005581 + +[Term] +id: GO:0016342 +name: catenin complex +namespace: cellular_component +def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] +is_a: GO:0019897 ! extrinsic to plasma membrane +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0016343 +name: cytoskeletal anchoring activity +namespace: molecular_function +def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0007016 + +[Term] +id: GO:0016344 +name: meiotic chromosome movement towards spindle pole +namespace: biological_process +def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai] +synonym: "chromosome migration to spindle pole during meiosis" EXACT [] +synonym: "chromosome movement towards spindle pole during meiosis" EXACT [] +synonym: "meiotic chromosome movement" BROAD [] +synonym: "meiotic chromosome movement to spindle pole" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051305 ! chromosome movement towards spindle pole +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0016345 +name: female meiotic chromosome movement towards spindle pole +namespace: biological_process +def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai] +synonym: "chromosome movement towards spindle pole during female meiosis" EXACT [] +synonym: "female meiotic chromosome movement" BROAD [] +synonym: "female meiotic chromosome movement to spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +relationship: part_of GO:0016321 ! female meiosis chromosome segregation + +[Term] +id: GO:0016346 +name: male meiotic chromosome movement towards spindle pole +namespace: biological_process +def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai] +synonym: "chromosome movement towards spindle pole during male meiosis" EXACT [] +synonym: "male meiotic chromosome movement" BROAD [] +synonym: "male meiotic chromosome movement to spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +relationship: part_of GO:0007060 ! male meiosis chromosome segregation + +[Term] +id: GO:0016347 +name: calcium-independent cell adhesion molecule activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005515 +consider: GO:0007161 +consider: GO:0016021 +consider: GO:0016338 + +[Term] +id: GO:0016348 +name: imaginal disc-derived leg joint morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. Morphogenesis pertains to the creation of form. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/] +synonym: "leg joint morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0035111 ! leg joint morphogenesis +relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis + +[Term] +id: GO:0016351 +name: drug susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0042493 + +[Term] +id: GO:0016352 +name: insecticide susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0017085 + +[Term] +id: GO:0016353 +name: carbamate susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046681 + +[Term] +id: GO:0016354 +name: cyclodiene susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046682 + +[Term] +id: GO:0016355 +name: DDT susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046680 + +[Term] +id: GO:0016356 +name: organophosphorus susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046683 + +[Term] +id: GO:0016357 +name: pyrethroid susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046684 + +[Term] +id: GO:0016358 +name: dendrite development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0031175 ! neurite development + +[Term] +id: GO:0016360 +name: sensory organ precursor cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0008052 ! sensory organ boundary specification + +[Term] +id: GO:0016361 +name: activin receptor activity, type I +namespace: molecular_function +def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] +synonym: "type I activin receptor activity" EXACT [] +is_a: GO:0005025 ! transforming growth factor beta receptor activity, type I +is_a: GO:0017002 ! activin receptor activity + +[Term] +id: GO:0016362 +name: activin receptor activity, type II +namespace: molecular_function +def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to catalyzes the phosphorylation of type I activin receptor." [GOC:mah, PMID:8622651] +synonym: "type II activin receptor activity" EXACT [] +is_a: GO:0005026 ! transforming growth factor beta receptor activity, type II +is_a: GO:0017002 ! activin receptor activity + +[Term] +id: GO:0016363 +name: nuclear matrix +namespace: cellular_component +def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0034399 ! nuclear periphery + +[Term] +id: GO:0016401 +name: palmitoyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + H2O2." [GOC:jsg] +xref: EC:1.3.3.- +is_a: GO:0003997 ! acyl-CoA oxidase activity + +[Term] +id: GO:0016402 +name: pristanoyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + H2O2." [GOC:jsg] +xref: EC:1.3.3.- +is_a: GO:0003997 ! acyl-CoA oxidase activity + +[Term] +id: GO:0016403 +name: dimethylargininase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18] +subset: gosubset_prok +synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] +synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] +synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18] +synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] +xref: EC:3.5.3.18 +xref: MetaCyc:DIMETHYLARGININASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0016404 +name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] +synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] +synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] +synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] +synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141] +synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141] +synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141] +synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] +synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] +xref: EC:1.1.1.141 +xref: MetaCyc:1.1.1.141-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016405 +name: CoA-ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai] +subset: gosubset_prok +xref: Reactome:10971 +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0016406 +name: carnitine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0016407 +name: acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] +subset: gosubset_prok +synonym: "acetylase activity" EXACT [] +xref: EC:2.3.1.- +xref: Reactome:1621 +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016408 +name: C-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016409 +name: palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016410 +name: N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +xref: Reactome:1095 +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016411 +name: acylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0016412 +name: serine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0016413 +name: O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0016414 +name: O-octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016415 ! octanoyltransferase activity + +[Term] +id: GO:0016415 +name: octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016416 +name: O-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016409 ! palmitoyltransferase activity + +[Term] +id: GO:0016417 +name: S-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016418 +name: S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0016407 ! acetyltransferase activity +is_a: GO:0016417 ! S-acyltransferase activity + +[Term] +id: GO:0016419 +name: S-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0016417 ! S-acyltransferase activity +is_a: GO:0016420 ! malonyltransferase activity + +[Term] +id: GO:0016420 +name: malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016421 +name: CoA carboxylase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:6.4.1.- +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0016422 +name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62] +synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62] +synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62] +synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62] +xref: EC:2.1.1.62 +xref: MetaCyc:2.1.1.62-RXN +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0016423 +name: tRNA (guanine) methyltransferase activity +namespace: molecular_function +alt_id: GO:0016424 +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in a tRNA molecule." [GOC:mah] +subset: gosubset_prok +synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016426 +name: tRNA (adenine)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in a tRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016427 +name: tRNA (cytosine)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in a tRNA molecule." [GOC:mah] +xref: EC:2.1.1.- +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016428 +name: tRNA (cytosine-5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29] +synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29] +synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] +synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] +xref: EC:2.1.1.29 +xref: MetaCyc:TRNA-(CYTOSINE-5-)-METHYLTRANSFERASE-RXN +is_a: GO:0016427 ! tRNA (cytosine)-methyltransferase activity + +[Term] +id: GO:0016429 +name: tRNA (adenine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36] +subset: gosubset_prok +synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36] +synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36] +synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36] +synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36] +xref: EC:2.1.1.36 +xref: MetaCyc:TRNA-(ADENINE-N1-)-METHYLTRANSFERASE-RXN +is_a: GO:0016426 ! tRNA (adenine)-methyltransferase activity + +[Term] +id: GO:0016430 +name: tRNA (adenine-N6-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55] +xref: EC:2.1.1.55 +xref: MetaCyc:TRNA-(ADENINE-N6-)-METHYLTRANSFERASE-RXN +is_a: GO:0016426 ! tRNA (adenine)-methyltransferase activity + +[Term] +id: GO:0016432 +name: tRNA-uridine aminocarboxypropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25] +synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25] +xref: EC:2.5.1.25 +xref: MetaCyc:2.5.1.25-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0016433 +name: rRNA (adenine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016434 +name: rRNA (cytosine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in an rRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016435 +name: rRNA (guanine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in an rRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016436 +name: rRNA (uridine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a uridine residue in an rRNA molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016437 +name: tRNA cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21] +synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21] +synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] +synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] +synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" EXACT [EC:2.7.7.21] +synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] +synonym: "CTP:tRNA cytidylyltransferase activity" EXACT [] +synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21] +synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21] +synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21] +synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21] +synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21] +xref: EC:2.7.7.21 +xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0016438 +name: tRNA-queuosine beta-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110] +synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110] +xref: EC:2.4.1.110 +xref: MetaCyc:2.4.1.110-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0016441 +name: posttranscriptional gene silencing +namespace: biological_process +def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054] +synonym: "cosuppression" RELATED [] +synonym: "PTGS" EXACT [] +synonym: "quelling" EXACT [] +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0016458 ! gene silencing +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0016442 +name: RNA-induced silencing complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] +synonym: "RISC complex" EXACT [] +is_a: GO:0031332 ! RNAi effector complex + +[Term] +id: GO:0016443 +name: bidentate ribonuclease III activity +namespace: molecular_function +def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] +synonym: "bidentate RNase III activity" EXACT [] +xref: EC:3.1.26.- +is_a: GO:0004525 ! ribonuclease III activity + +[Term] +id: GO:0016444 +name: somatic cell DNA recombination +namespace: biological_process +def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0016445 +name: somatic diversification of immunoglobulins +namespace: biological_process +def: "The somatic process by means of which sequence diversity of immunoglobulins is generated." [GOC:add, GOC:ma, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic diversification of antibodies" EXACT [] +is_a: GO:0002200 ! somatic diversification of immune receptors +relationship: part_of GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0016446 +name: somatic hypermutation of immunoglobulin genes +namespace: biological_process +def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] +synonym: "somatic hypermutation of antibody genes" EXACT [] +is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0016447 +name: somatic recombination of immunoglobulin gene segments +namespace: biological_process +def: "The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "somatic recombination of antibody gene segments" EXACT [] +is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0016453 +name: C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +is_a: GO:0016407 ! acetyltransferase activity +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0016454 +name: C-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0016408 ! C-acyltransferase activity +is_a: GO:0016409 ! palmitoyltransferase activity + +[Term] +id: GO:0016455 +name: RNA polymerase II transcription mediator activity +namespace: molecular_function +def: "Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex." [GOC:ma] +synonym: "thyroid receptor-associated protein" RELATED [] +synonym: "TRAP protein" RELATED [] +is_a: GO:0016251 ! general RNA polymerase II transcription factor activity + +[Term] +id: GO:0016456 +name: X chromosome located dosage compensation complex, transcription activating +namespace: cellular_component +def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome." [GOC:ma, GOC:mtg_sensu] +synonym: "dosage compensation complex (sensu Insecta)" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0046536 ! dosage compensation complex +relationship: part_of GO:0000805 ! X chromosome + +[Term] +id: GO:0016457 +name: dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome." [GOC:jl] +synonym: "dosage compensation complex assembly (sensu Insecta)" EXACT [] +is_a: GO:0042714 ! dosage compensation complex assembly +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0009047 ! dosage compensation, by hyperactivation of X chromosome + +[Term] +id: GO:0016458 +name: gene silencing +namespace: biological_process +def: "Any mechanism, at the level of transcription or post-transcription, causing long-term gene inactivation." [GOC:jic] +comment: Note that this process is the opposite of long-term maintenance of gene activation. +subset: goslim_pir +synonym: "long-term maintenance of gene inactivation" RELATED [] +is_a: GO:0010629 ! negative regulation of gene expression + +[Term] +id: GO:0016459 +name: myosin complex +namespace: cellular_component +def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0016460 +name: myosin II complex +namespace: cellular_component +def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] +synonym: "conventional myosin" RELATED [] +is_a: GO:0016459 ! myosin complex + +[Term] +id: GO:0016461 +name: unconventional myosin complex +namespace: cellular_component +alt_id: GO:0005860 +def: "A portmanteau term for myosins other than myosin II." [GOC:ma] +comment: Note that this term is retained because it is widely used by biologists. +synonym: "non-muscle myosin" RELATED [] +is_a: GO:0016459 ! myosin complex + +[Term] +id: GO:0016462 +name: pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +xref: EC:3.6.1.- +xref: Reactome:3222 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0016463 +name: zinc-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)." [EC:3.6.3.5] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "AtHMA4" RELATED [EC:3.6.3.5] +synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [EC:3.6.3.5] +synonym: "P(1B)-type ATPase activity" NARROW [EC:3.6.3.5] +synonym: "P1B-type ATPase activity" EXACT [EC:3.6.3.5] +synonym: "zinc exporting ATPase activity" EXACT [] +synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:3.6.3.5] +synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:3.6.3.5] +synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:3.6.3.5] +synonym: "Zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] +synonym: "zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] +xref: EC:3.6.3.5 +xref: MetaCyc:3.6.3.5-RXN +is_a: GO:0005385 ! zinc ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0016464 +name: chloroplast protein-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:3.6.3.52] +synonym: "chloroplast protein ABC transporter" NARROW [] +xref: EC:3.6.3.52 +xref: MetaCyc:3.6.3.52-RXN +is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity + +[Term] +id: GO:0016465 +name: chaperonin ATPase complex +namespace: cellular_component +def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0016466 +name: hydrogen-translocating A-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "proton-translocating A-type ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0046961 + +[Term] +id: GO:0016467 +name: hydrogen-translocating F-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "ATP synthase" BROAD [] +synonym: "F1-ATPase activity" EXACT [] +synonym: "proton-translocating F-type ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0046933 +replaced_by: GO:0046961 + +[Term] +id: GO:0016468 +name: sodium-translocating F-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2] +comment: This term was made obsolete because it represents a gene product. +synonym: "ATP synthase" BROAD [] +is_obsolete: true +replaced_by: GO:0046932 +replaced_by: GO:0046962 + +[Term] +id: GO:0016469 +name: proton-transporting two-sector ATPase complex +namespace: cellular_component +def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] +subset: goslim_pir +subset: gosubset_prok +synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] +synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0016471 +name: vacuolar proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] +comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. +subset: gosubset_prok +synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT [] +is_a: GO:0033176 ! proton-transporting V-type ATPase complex +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0016472 +name: sodium ion-transporting two-sector ATPase complex +namespace: cellular_component +def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431] +subset: goslim_pir +synonym: "sodium-transporting two-sector ATPase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016021 ! integral to membrane + +[Term] +id: GO:0016473 +name: sodium ion-transporting F-type ATPase complex +namespace: cellular_component +def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431] +synonym: "sodium-translocating F-type ATPase complex" EXACT [] +is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex + +[Term] +id: GO:0016474 +name: sodium ion-transporting V-type ATPase complex +namespace: cellular_component +def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565] +synonym: "sodium-translocating V-type ATPase complex" EXACT [] +is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex + +[Term] +id: GO:0016475 +name: detection of nuclear:cytoplasmic ratio +namespace: biological_process +def: "The process by which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl] +synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT [] +synonym: "sensing of nuclear:cytoplasmic ratio" EXACT [] +is_a: GO:0009726 ! detection of endogenous stimulus +relationship: part_of GO:0016049 ! cell growth + +[Term] +id: GO:0016476 +name: regulation of embryonic cell shape +namespace: biological_process +def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] +synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb] +is_a: GO:0008360 ! regulation of cell shape +is_a: GO:0045995 ! regulation of embryonic development + +[Term] +id: GO:0016477 +name: cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another, often during the development of a multicellular organism." [GOC:ems] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0016479 +name: negative regulation of transcription from RNA polymerase I promoter +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW [] +synonym: "negative regulation of transcription from Pol I promoter" EXACT [] +is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +relationship: negatively_regulates GO:0006360 ! transcription from RNA polymerase I promoter + +[Term] +id: GO:0016480 +name: negative regulation of transcription from RNA polymerase III promoter +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW [] +synonym: "negative regulation of transcription from Pol III promoter" EXACT [] +is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +relationship: negatively_regulates GO:0006383 ! transcription from RNA polymerase III promoter + +[Term] +id: GO:0016481 +name: negative regulation of transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of transcription" EXACT [] +synonym: "down-regulation of transcription" EXACT [] +synonym: "downregulation of transcription" EXACT [] +synonym: "inhibition of transcription" NARROW [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045449 ! regulation of transcription +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: negatively_regulates GO:0006350 ! transcription + +[Term] +id: GO:0016482 +name: cytoplasmic transport +namespace: biological_process +def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell." [GOC:ai] +synonym: "cytoplasmic streaming" NARROW [] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0016483 +name: tryptophan hydroxylase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0016484 +name: proprotein convertase 2 activator activity +namespace: molecular_function +def: "Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0016485 +name: protein processing +namespace: biological_process +def: "The posttranslational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations." [GOC:jl, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0016486 +name: peptide hormone processing +namespace: biological_process +def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] +is_a: GO:0016485 ! protein processing +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0016487 +name: farnesol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] +subset: gosubset_prok +synonym: "farnesol metabolism" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0034308 ! monohydric alcohol metabolic process + +[Term] +id: GO:0016488 +name: farnesol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] +subset: gosubset_prok +synonym: "farnesol breakdown" EXACT [] +synonym: "farnesol catabolism" EXACT [] +synonym: "farnesol degradation" EXACT [] +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:0016487 ! farnesol metabolic process +is_a: GO:0034310 ! monohydric alcohol catabolic process + +[Term] +id: GO:0016490 +name: structural constituent of peritrophic membrane +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "structural constituent of peritrophic matrix (sensu Insecta)" EXACT [] +synonym: "structural constituent of peritrophic membrane (sensu Insecta)" EXACT [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0016491 +name: oxidoreductase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] +comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. +subset: goslim_candida +subset: goslim_goa +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on other substrates" NARROW [] +synonym: "redox activity" EXACT [] +xref: EC:1 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016492 +name: neurotensin receptor activity, G-protein coupled +namespace: molecular_function +def: "G-protein coupled receptor for the tridecapeptide neurotensin. Associated with G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)." [UniProtKB:O95665] +synonym: "G protein coupled neurotensin receptor activity" EXACT [] +synonym: "G-protein coupled neurotensin receptor activity" EXACT [] +synonym: "G-protein-coupled neurotensin receptor activity" EXACT [] +synonym: "neurotensin receptor activity, G protein coupled" EXACT [] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0016493 +name: C-C chemokine receptor activity +namespace: molecular_function +def: "Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [PMID:8662823] +is_a: GO:0004950 ! chemokine receptor activity +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0016494 +name: C-X-C chemokine receptor activity +namespace: molecular_function +def: "Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [PMID:8662823] +is_a: GO:0004950 ! chemokine receptor activity +is_a: GO:0019958 ! C-X-C chemokine binding + +[Term] +id: GO:0016495 +name: C-X3-C chemokine receptor activity +namespace: molecular_function +def: "Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph] +is_a: GO:0004950 ! chemokine receptor activity +is_a: GO:0019960 ! C-X3-C chemokine binding + +[Term] +id: GO:0016496 +name: substance P receptor activity +namespace: molecular_function +def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004995 ! tachykinin receptor activity + +[Term] +id: GO:0016497 +name: substance K receptor activity +namespace: molecular_function +def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "neurokinin A receptor activity" EXACT [] +synonym: "neuromedin L receptor activity" EXACT [] +is_a: GO:0004995 ! tachykinin receptor activity + +[Term] +id: GO:0016498 +name: neuromedin K receptor activity +namespace: molecular_function +def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "neurokinin B receptor activity" EXACT [] +is_a: GO:0004995 ! tachykinin receptor activity + +[Term] +id: GO:0016499 +name: orexin receptor activity +namespace: molecular_function +def: "Combining with orexin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0016500 +name: protein-hormone receptor activity +namespace: molecular_function +def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0016501 +name: prostacyclin receptor activity +namespace: molecular_function +alt_id: GO:0004959 +def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "PGI receptor activity" RELATED [] +synonym: "PGI(2) receptor activity" EXACT [] +synonym: "prostaglandin I receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0016502 +name: nucleotide receptor activity +namespace: molecular_function +def: "Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0016503 +name: pheromone receptor activity +namespace: molecular_function +def: "Combining with a pheromone to initiate a change in cell activity." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0016504 +name: protease activator activity +namespace: molecular_function +def: "Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds." [GOC:ai] +subset: gosubset_prok +xref: Reactome:11526 +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0016505 +name: apoptotic protease activator activity +namespace: molecular_function +is_a: GO:0016504 ! protease activator activity + +[Term] +id: GO:0016506 +name: apoptosis activator activity +namespace: molecular_function +def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb] +comment: This term was made obsolete because it represents involvement in a biological process. +is_obsolete: true +replaced_by: GO:0006917 + +[Term] +id: GO:0016507 +name: fatty acid beta-oxidation multienzyme complex +namespace: cellular_component +def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma] +synonym: "trifunctional enzyme" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0016508 +name: long-chain-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.74] +synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74] +synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74] +xref: EC:4.2.1.74 +xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0016509 +name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. Acts most rapidly on derivatives with chain length 8 or 10." [EC:1.1.1.211] +comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. +subset: gosubset_prok +synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211] +synonym: "LCHAD" RELATED [EC:1.1.1.211] +synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211] +synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211] +xref: EC:1.1.1.211 +xref: MetaCyc:1.1.1.211-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016511 +name: endothelin-converting enzyme activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0016512 +name: endothelin-converting enzyme 1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "ECE-1 activity" EXACT [EC:3.4.24.71] +xref: EC:3.4.24.71 +xref: MetaCyc:3.4.24.71-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0016513 +name: core-binding factor complex +namespace: cellular_component +def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254] +synonym: "AML1 complex" NARROW [] +synonym: "CBF complex" EXACT [] +synonym: "PEPB2 complex" NARROW [] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0016514 +name: SWI/SNF complex +namespace: cellular_component +def: "Any of a family of protein complexes that regulate transcription by remodeling chromatin. Swi/Snf complexes comprise nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0016515 +name: interleukin-13 receptor activity +namespace: molecular_function +def: "Combining with interleukin-13 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-13R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019973 ! interleukin-13 binding + +[Term] +id: GO:0016516 +name: interleukin-4 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-4, consisting of alpha, beta, and gamma chains; exists in three forms, one containing extracellular transmembrane and cytoplasmic domains, one lacking the cytoplasmic domain and a third that is secreted." [UniProtKB:P16382] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0016517 +name: interleukin-12 receptor activity +namespace: molecular_function +def: "Combining with interleukin-12 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-12R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019972 ! interleukin-12 binding + +[Term] +id: GO:0016518 +name: interleukin-14 receptor activity +namespace: molecular_function +def: "Combining with interleukin-14 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-14R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019974 ! interleukin-14 binding + +[Term] +id: GO:0016519 +name: gastric inhibitory peptide receptor activity +namespace: molecular_function +def: "Combining with gastric inhibitory peptide to initiate a change in cell activity." [UniProtKB:P48546] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0016520 +name: growth hormone-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [UniProtKB:P32082] +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0016521 +name: pituitary adenylate cyclase activating polypeptide activity +namespace: molecular_function +synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016524 +name: latrotoxin receptor activity +namespace: molecular_function +def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity." [GOC:jl, PMID:10025961] +synonym: "latrophilin" NARROW [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0016525 +name: negative regulation of angiogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] +synonym: "down regulation of angiogenesis" EXACT [] +synonym: "down-regulation of angiogenesis" EXACT [] +synonym: "downregulation of angiogenesis" EXACT [] +synonym: "inhibition of angiogenesis" NARROW [] +is_a: GO:0045765 ! regulation of angiogenesis +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0001525 ! angiogenesis + +[Term] +id: GO:0016527 +name: brain-specific angiogenesis inhibitor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0016528 +name: sarcoplasm +namespace: cellular_component +def: "The cytoplasm of a muscle fiber; includes the sarcoplasmic reticulum." [ISBN:0198547684] +is_a: GO:0005737 ! cytoplasm + +[Term] +id: GO:0016529 +name: sarcoplasmic reticulum +namespace: cellular_component +alt_id: GO:0008221 +def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle fiber; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] +comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. +is_a: GO:0005783 ! endoplasmic reticulum +relationship: part_of GO:0016528 ! sarcoplasm + +[Term] +id: GO:0016530 +name: metallochaperone activity +namespace: molecular_function +def: "Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0016531 +name: copper chaperone activity +namespace: molecular_function +def: "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376] +is_a: GO:0005507 ! copper ion binding +is_a: GO:0016530 ! metallochaperone activity + +[Term] +id: GO:0016532 +name: superoxide dismutase copper chaperone activity +namespace: molecular_function +def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase." [http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:9295278] +comment: See also the molecular function term 'copper, zinc superoxide dismutase activity ; GO:0004785'. +is_a: GO:0016531 ! copper chaperone activity + +[Term] +id: GO:0016533 +name: cyclin-dependent protein kinase 5 activator complex +namespace: cellular_component +def: "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [UniProtKB:Q62938] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0016534 +name: cyclin-dependent protein kinase 5 activator activity +namespace: molecular_function +alt_id: GO:0016535 +synonym: "cyclin-dependent protein kinase 5 activator, intrinsic catalyst activity" EXACT [] +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0016536 +name: cyclin-dependent protein kinase 5 activator regulator activity +namespace: molecular_function +def: "Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai] +synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0016538 +name: cyclin-dependent protein kinase regulator activity +namespace: molecular_function +alt_id: GO:0003751 +alt_id: GO:0003752 +alt_id: GO:0003753 +def: "Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:rn, PMID:7877684, PMID:9442875] +synonym: "cyclin" BROAD [] +synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW [] +synonym: "G1/S-specific cyclin" NARROW [] +synonym: "G2/M-specific cyclin" NARROW [] +xref: EC:2.7.1.- +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0016539 +name: intein-mediated protein splicing +namespace: biological_process +def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] +subset: gosubset_prok +synonym: "intein" RELATED [] +is_a: GO:0030908 ! protein splicing + +[Term] +id: GO:0016540 +name: protein autoprocessing +namespace: biological_process +def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] +subset: gosubset_prok +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0016541 +name: intein +namespace: molecular_function +def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123] +comment: This term was made obsolete because it refers to a protein sequence feature. +is_obsolete: true +consider: GO:0004519 +consider: GO:0016539 + +[Term] +id: GO:0016543 +name: male courtship behavior, orientation prior to leg tapping and wing vibration +namespace: biological_process +def: "The process during courtship, where the male orients towards a potential partner." [GOC:sensu, PMID:11092827] +synonym: "male courtship behavior (sensu Insecta), orientation" EXACT [] +synonym: "male courtship behaviour (sensu Insecta), orientation" EXACT [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0016544 +name: male courtship behavior, tapping to detect pheromone +namespace: biological_process +def: "The process during courtship where the male insect taps the female with his frontal leg." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior (sensu Insecta), tapping" EXACT [] +synonym: "male courtship behaviour (sensu Insecta), tapping" EXACT [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0016545 +name: male courtship behavior, veined wing vibration +namespace: biological_process +def: "The process during courtship where the male insect vibrates his wings." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior (sensu Insecta), wing vibration" EXACT [] +synonym: "male courtship behaviour (sensu Insecta), wing vibration" EXACT [] +synonym: "male courtship behaviour, veined wing vibration" EXACT [] +is_a: GO:0048065 ! male courtship behavior, veined wing extension + +[Term] +id: GO:0016546 +name: male courtship behavior, proboscis-mediated licking +namespace: biological_process +def: "The process during courtship where the male licks the genitalia of a stationary female fly with his proboscis." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior (sensu Insecta), licking" EXACT [] +synonym: "male courtship behaviour (sensu Insecta), licking" EXACT [] +synonym: "male courtship behaviour, proboscis-mediated licking" EXACT [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0016550 +name: insertion or deletion editing +namespace: biological_process +def: "The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837] +subset: gosubset_prok +synonym: "insertion/deletion editing" EXACT [] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0016551 +name: posttranscriptional insertion or deletion editing +namespace: biological_process +def: "The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837] +subset: gosubset_prok +synonym: "posttranscriptional insertion/deletion editing" EXACT [] +is_a: GO:0016550 ! insertion or deletion editing + +[Term] +id: GO:0016552 +name: cotranscriptional insertion or deletion editing +namespace: biological_process +def: "The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837] +subset: gosubset_prok +synonym: "cotranscriptional insertion/deletion editing" EXACT [] +is_a: GO:0016550 ! insertion or deletion editing + +[Term] +id: GO:0016553 +name: base conversion or substitution editing +namespace: biological_process +def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837] +subset: gosubset_prok +synonym: "base conversion/substitution editing" EXACT [] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0016554 +name: cytidine to uridine editing +namespace: biological_process +def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837] +subset: gosubset_prok +xref: Reactome:72200 +is_a: GO:0016553 ! base conversion or substitution editing + +[Term] +id: GO:0016555 +name: uridine to cytidine editing +namespace: biological_process +def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837] +subset: gosubset_prok +is_a: GO:0016553 ! base conversion or substitution editing + +[Term] +id: GO:0016556 +name: mRNA modification +namespace: biological_process +alt_id: GO:0006381 +def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. +subset: gosubset_prok +synonym: "mRNA editing" EXACT [] +xref: Reactome:212100 +xref: Reactome:221859 +xref: Reactome:238469 +xref: Reactome:268504 +xref: Reactome:75072 +is_a: GO:0009451 ! RNA modification +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0016557 +name: peroxisome membrane biogenesis +namespace: biological_process +def: "The assembly and arrangement of the membrane of a peroxisome." [GOC:mah] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0007031 ! peroxisome organization + +[Term] +id: GO:0016558 +name: protein import into peroxisome matrix +namespace: biological_process +def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported." [ISBN:0716731363, PMID:11687502, PMID:11988772] +synonym: "peroxisome matrix protein import" EXACT [] +synonym: "protein transport to peroxisome matrix" EXACT [] +is_a: GO:0006625 ! protein targeting to peroxisome +is_a: GO:0017038 ! protein import + +[Term] +id: GO:0016559 +name: peroxisome fission +namespace: biological_process +def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] +synonym: "peroxisome division" EXACT [] +synonym: "peroxisome proliferation" EXACT [] +is_a: GO:0048285 ! organelle fission +relationship: part_of GO:0007031 ! peroxisome organization + +[Term] +id: GO:0016560 +name: protein import into peroxisome matrix, docking +namespace: biological_process +def: "The process by which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the preoxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507] +synonym: "peroxisome matrix protein import, docking" EXACT [] +synonym: "peroxisome receptor docking" RELATED [] +synonym: "protein docking during peroxisome matrix protein import" EXACT [] +synonym: "protein docking during protein import into peroxisome matrix" EXACT [] +synonym: "protein docking during protein transport into peroxisome matrix" EXACT [] +synonym: "protein transport into peroxisome matrix, docking" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0016561 +name: protein import into peroxisome matrix, translocation +namespace: biological_process +def: "The process by which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502] +synonym: "peroxisome matrix protein import, translocation" EXACT [] +synonym: "peroxisome receptor translocation" RELATED [] +synonym: "protein translocation during peroxisome matrix protein import" EXACT [] +synonym: "protein translocation during protein import into peroxisome matrix" EXACT [] +synonym: "protein translocation during protein transport into peroxisome matrix" EXACT [] +synonym: "protein transport into peroxisome matrix, translocation" EXACT [] +is_a: GO:0065002 ! intracellular protein transmembrane transport +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0016562 +name: protein import into peroxisome matrix, receptor recycling +namespace: biological_process +def: "The process by which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502] +synonym: "peroxisome matrix protein import, receptor recycling" EXACT [] +synonym: "peroxisome receptor recycling" RELATED [] +synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT [] +synonym: "PTS receptor recycling" RELATED [] +synonym: "receptor recycling during peroxisome matrix protein import" EXACT [] +synonym: "receptor recycling during protein import into peroxisome matrix" EXACT [] +synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT [] +is_a: GO:0001881 ! receptor recycling +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0016563 +name: transcription activator activity +namespace: molecular_function +alt_id: GO:0003710 +def: "Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653] +subset: gosubset_prok +synonym: "transcription activating factor" NARROW [] +synonym: "transcriptional activator activity" EXACT [] +xref: Reactome:9388 +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0016564 +name: transcription repressor activity +namespace: molecular_function +def: "Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah] +subset: gosubset_prok +synonym: "negative transcriptional regulator activity" EXACT [] +synonym: "transcriptional repressor activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0016565 +name: general transcriptional repressor activity +namespace: molecular_function +def: "Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah] +is_a: GO:0016564 ! transcription repressor activity + +[Term] +id: GO:0016566 +name: specific transcriptional repressor activity +namespace: molecular_function +def: "Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016564 ! transcription repressor activity + +[Term] +id: GO:0016567 +name: protein ubiquitination +namespace: biological_process +def: "The process by which one or more ubiquitin moieties are added to a protein." [GOC:ai] +synonym: "protein ubiquitinylation" EXACT [] +synonym: "protein ubiquitylation" EXACT [] +is_a: GO:0032446 ! protein modification by small protein conjugation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0016568 +name: chromatin modification +namespace: biological_process +def: "The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure." [GOC:mah] +is_a: GO:0006325 ! establishment or maintenance of chromatin architecture + +[Term] +id: GO:0016569 +name: covalent chromatin modification +namespace: biological_process +def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah] +is_a: GO:0016568 ! chromatin modification + +[Term] +id: GO:0016570 +name: histone modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] +is_a: GO:0016569 ! covalent chromatin modification +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0016571 +name: histone methylation +namespace: biological_process +def: "The modification of histones by addition of methyl groups." [GOC:ai] +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016572 +name: histone phosphorylation +namespace: biological_process +def: "The modification of histones by addition of phosphate groups." [GOC:ai] +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016573 +name: histone acetylation +namespace: biological_process +def: "The modification of histones by addition of acetyl groups." [GOC:ai] +is_a: GO:0006473 ! protein amino acid acetylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016574 +name: histone ubiquitination +namespace: biological_process +def: "The modification of histones by addition of ubiquitin groups." [GOC:ai] +synonym: "histone ubiquitinylation" EXACT [] +synonym: "histone ubiquitylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016575 +name: histone deacetylation +namespace: biological_process +def: "The modification of histones by removal of acetyl groups." [GOC:ai] +is_a: GO:0006476 ! protein amino acid deacetylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016576 +name: histone dephosphorylation +namespace: biological_process +def: "The modification of histones by removal of phosphate groups." [GOC:ai] +is_a: GO:0006470 ! protein amino acid dephosphorylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016577 +name: histone demethylation +namespace: biological_process +def: "The modification of histones by removal of methyl groups." [GOC:ai] +is_a: GO:0006482 ! protein amino acid demethylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016578 +name: histone deubiquitination +namespace: biological_process +def: "The modification of histones by removal of ubiquitin groups." [GOC:ai] +synonym: "histone deubiquitinylation" EXACT [] +synonym: "histone deubiquitylation" EXACT [] +is_a: GO:0016570 ! histone modification +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0016579 +name: protein deubiquitination +namespace: biological_process +alt_id: GO:0006514 +def: "The removal of one or more ubiquitin moieties from a protein." [GOC:ai] +synonym: "deubiquitination" EXACT [] +synonym: "protein deubiquitinylation" EXACT [] +synonym: "protein deubiquitylation" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0016580 +name: Sin3 complex +namespace: cellular_component +def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0016581 +name: NuRD complex +namespace: cellular_component +def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] +synonym: "Mi-2 complex" EXACT [] +synonym: "NRD complex" EXACT [] +synonym: "nucleosome remodeling and histone deacetylation complex" EXACT [] +synonym: "SHREC complex" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0016582 +name: non-covalent chromatin modification +namespace: biological_process +def: "The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl] +is_a: GO:0016568 ! chromatin modification + +[Term] +id: GO:0016583 +name: nucleosome modeling +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it has been replaced by more specific terms. +is_obsolete: true +consider: GO:0006334 + +[Term] +id: GO:0016584 +name: nucleosome positioning +namespace: biological_process +def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389] +synonym: "nucleosome spacing" EXACT [] +is_a: GO:0031497 ! chromatin assembly +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0016585 +name: chromatin remodeling complex +namespace: cellular_component +alt_id: GO:0005679 +def: "Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah] +subset: goslim_pir +synonym: "chromatin remodelling complex" EXACT [] +synonym: "nucleosome remodeling complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0016586 +name: RSC complex +namespace: cellular_component +def: "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [PMID:11937489, PMID:12672490, PMID:15870268, PMID:8980231] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0016587 +name: ISW1 complex +namespace: cellular_component +def: "A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure." [GOC:mah, PMID:15020051] +is_a: GO:0031010 ! ISWI complex + +[Term] +id: GO:0016589 +name: NURF complex +namespace: cellular_component +def: "A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones." [GOC:bf, PMID:10779516, PMID:11279013] +synonym: "nucleosome remodeling factor complex" EXACT [] +is_a: GO:0031010 ! ISWI complex + +[Term] +id: GO:0016590 +name: ACF complex +namespace: cellular_component +def: "A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI." [GOC:bf, PMID:12192034] +synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT [] +is_a: GO:0005678 ! chromatin assembly complex + +[Term] +id: GO:0016591 +name: DNA-directed RNA polymerase II, holoenzyme +namespace: cellular_component +def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, http://en.wikipedia.org/, PMID:15196470] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0016592 +name: Srb-mediator complex +namespace: cellular_component +def: "A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins." [PMID:16168358, PMID:9396788] +synonym: "CDK8-containing TRAP/mediator complex" EXACT [] +synonym: "L mediator complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0016593 +name: Cdc73/Paf1 complex +namespace: cellular_component +def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Hpr1p, Ccr4p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586] +is_a: GO:0008023 ! transcription elongation factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0016594 +name: glycine binding +namespace: molecular_function +def: "Interacting selectively with glycine, aminoethanoic acid." [GOC:ai] +synonym: "aminoacetic acid binding" EXACT [] +synonym: "aminoethanoic acid binding" EXACT [] +synonym: "Gly binding" EXACT [] +is_a: GO:0016597 ! amino acid binding + +[Term] +id: GO:0016595 +name: glutamate binding +namespace: molecular_function +def: "Interacting selectively with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] +synonym: "glutamic acid binding" EXACT [] +is_a: GO:0016597 ! amino acid binding + +[Term] +id: GO:0016596 +name: thienylcyclohexylpiperidine binding +namespace: molecular_function +def: "Interacting selectively with thienylcyclohexylpiperidine." [GOC:jl] +synonym: "TCP binding" BROAD [] +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0016597 +name: amino acid binding +namespace: molecular_function +def: "Interacting selectively with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0016598 +name: protein arginylation +namespace: biological_process +alt_id: GO:0019130 +def: "The posttranslational conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [UniProtKB:O96539] +synonym: "protein amino acid arginylation" EXACT [] +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0016600 +name: flotillin complex +namespace: cellular_component +def: "A heteromeric complex of flotillin 1, flotillin 2, caveolin 1 and caveolin 2 within the caveolar membrane." [UniProtKB:O61491] +comment: See also the cellular component term 'caveolar membrane ; GO:0016599'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005901 ! caveola + +[Term] +id: GO:0016601 +name: Rac protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] +synonym: "Rac mediated signal transduction" EXACT [] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0016602 +name: CCAAT-binding factor complex +namespace: cellular_component +def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0016603 +name: glutaminyl-peptide cyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] +subset: gosubset_prok +synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5] +synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5] +synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] +synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5] +xref: EC:2.3.2.5 +xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0016604 +name: nuclear body +namespace: cellular_component +def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0016605 +name: PML body +namespace: cellular_component +def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] +synonym: "ND10" EXACT [] +synonym: "nuclear dot" RELATED [] +synonym: "PML NB" EXACT [] +synonym: "PML nuclear body" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0016606 +name: Lands +namespace: cellular_component +def: "A class of nuclear body (Lands = LYSP100-associated nuclear domains); they are globular, electron-dense structures that may traffic between the nucleus and cytoplasm; they react against SP140 auto-antibodies." [UniProtKB:Q13342] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0016607 +name: nuclear speck +namespace: cellular_component +def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] +synonym: "nuclear speckle" EXACT [] +synonym: "nuclear speckles" EXACT [] +synonym: "speckle domain" NARROW [] +synonym: "speckle focus" RELATED [] +synonym: "splicing speckle" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0016608 +name: growth hormone-releasing hormone activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016609 +name: G-protein coupled serotonin receptor activity +namespace: molecular_function +synonym: "G protein coupled serotonin receptor activity" EXACT [] +synonym: "G-protein-coupled serotonin receptor activity" EXACT [] +is_a: GO:0004993 ! serotonin receptor activity + +[Term] +id: GO:0016610 +name: nitrogenase complex +namespace: cellular_component +def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0016611 +name: iron-iron nitrogenase complex +namespace: cellular_component +def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850] +comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. +subset: gosubset_prok +is_a: GO:0016610 ! nitrogenase complex + +[Term] +id: GO:0016612 +name: molybdenum-iron nitrogenase complex +namespace: cellular_component +def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1] +subset: gosubset_prok +synonym: "molybdenum-iron nitrogenase activity" RELATED [] +is_a: GO:0016610 ! nitrogenase complex + +[Term] +id: GO:0016613 +name: vanadium-iron nitrogenase complex +namespace: cellular_component +def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027] +subset: gosubset_prok +synonym: "vanadium-iron nitrogenase activity" RELATED [] +is_a: GO:0016610 ! nitrogenase complex + +[Term] +id: GO:0016614 +name: oxidoreductase activity, acting on CH-OH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] +xref: EC:1.1 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016615 +name: malate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] +subset: gosubset_prok +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016616 +name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +subset: gosubset_prok +xref: EC:1.1.1 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016617 +name: 4-oxoproline reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104] +synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104] +synonym: "hydroxy-L-proline oxidase activity" EXACT [] +synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104] +xref: EC:1.1.1.104 +xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016618 +name: hydroxypyruvate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81] +subset: gosubset_prok +synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] +synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81] +synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81] +synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] +xref: EC:1.1.1.81 +xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016619 +name: malate dehydrogenase (oxaloacetate-decarboxylating) activity +namespace: molecular_function +alt_id: GO:0004472 +def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.38] +subset: gosubset_prok +synonym: "'malic' enzyme" RELATED [EC:1.1.1.38] +synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38] +synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] +synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38] +synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38] +xref: EC:1.1.1.38 +xref: MetaCyc:MALIC-NAD-RXN +is_a: GO:0004470 ! malic enzyme activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016620 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +xref: EC:1.2.1 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016621 +name: cinnamoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44] +synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44] +synonym: "cinnamoyl CoA reductase activity" EXACT [] +synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44] +synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44] +synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] +synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44] +synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44] +synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] +xref: EC:1.2.1.44 +xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016622 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +subset: gosubset_prok +xref: EC:1.2.2 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016623 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.2.3 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016624 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.2.4 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016625 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.2.7 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016626 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016903 + +[Term] +id: GO:0016627 +name: oxidoreductase activity, acting on the CH-CH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] +xref: EC:1.3 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016628 +name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +xref: EC:1.3.1 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016629 +name: 12-oxophytodienoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-((1R,2R)-3-oxo-2-((Z)-pent-2-enyl)cyclopentyl)octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + NADPH." [EC:1.3.1.42] +synonym: "12-oxo-phytodienoate reductase activity" EXACT [] +synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42] +synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42] +xref: EC:1.3.1.42 +xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016630 +name: protochlorophyllide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] +subset: gosubset_prok +synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33] +synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] +synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33] +synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] +synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] +synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33] +xref: EC:1.3.1.33 +xref: MetaCyc:PROTOCHLOROPHYLLIDE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016631 +name: enoyl-[acyl-carrier-protein] reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb] +subset: gosubset_prok +synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.-] +synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT [] +synonym: "enoyl-ACP reductase activity" EXACT [] +synonym: "enoyl-acyl carrier protein reductase" EXACT [] +xref: EC:1.3.1.- +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016632 +name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +xref: EC:1.3.2 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016633 +name: galactonolactone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3] +synonym: "GLDase activity" EXACT [EC:1.3.2.3] +synonym: "GLDHase activity" EXACT [EC:1.3.2.3] +synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT [] +synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] +synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3] +synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] +synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3] +xref: EC:1.3.2.3 +xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN +is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor + +[Term] +id: GO:0016634 +name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.3.3 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016635 +name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] +subset: gosubset_prok +xref: EC:1.3.5 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016636 +name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.3.7 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016637 +name: oxidoreductase activity, acting on the CH-CH group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016627 + +[Term] +id: GO:0016638 +name: oxidoreductase activity, acting on the CH-NH2 group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] +xref: EC:1.4 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016639 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +subset: gosubset_prok +xref: EC:1.4.1 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016640 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] +xref: EC:1.4.2 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016641 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:1.4.3 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016642 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.4.4 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016643 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.4.7 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016644 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016638 + +[Term] +id: GO:0016645 +name: oxidoreductase activity, acting on the CH-NH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] +xref: EC:1.5 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016646 +name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +xref: EC:1.5.1 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016647 +name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.5.3 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016648 +name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] +synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.5.4 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016649 +name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl] +subset: gosubset_prok +xref: EC:1.5.5 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016650 +name: oxidoreductase activity, acting on the CH-NH group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016645 + +[Term] +id: GO:0016651 +name: oxidoreductase activity, acting on NADH or NADPH +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "NAD(P)H dehydrogenase" NARROW [] +synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] +xref: EC:1.6 +xref: Reactome:4134 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016652 +name: oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +subset: gosubset_prok +xref: EC:1.6.1 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0016653 +name: oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] +xref: EC:1.6.2 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0016654 +name: oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] +xref: EC:1.6.4 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0016655 +name: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:1.6.5 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0016656 +name: monodehydroascorbate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4] +synonym: "AFR" RELATED [EC:1.6.5.4] +synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4] +synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4] +synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4] +synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4] +synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4] +synonym: "MDHA" RELATED [EC:1.6.5.4] +synonym: "monodehydroascorbate reductase activity" EXACT [] +synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] +synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4] +synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4] +synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] +synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4] +synonym: "SDA reductase activity" EXACT [EC:1.6.5.4] +synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4] +xref: EC:1.6.5.4 +xref: MetaCyc:1.6.5.4-RXN +is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor + +[Term] +id: GO:0016657 +name: oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai] +subset: gosubset_prok +xref: EC:1.6.6 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0016658 +name: oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it. +is_obsolete: true +consider: GO:0008752 +consider: GO:0042602 + +[Term] +id: GO:0016659 +name: oxidoreductase activity, acting on NADH or NADPH, other acceptor +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016651 + +[Term] +id: GO:0016661 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW [] +xref: EC:1.7 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016662 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +subset: gosubset_prok +xref: EC:1.7.2 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016663 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.7.3 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016664 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.7.7 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016665 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016661 + +[Term] +id: GO:0016667 +name: oxidoreductase activity, acting on sulfur group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] +synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] +xref: EC:1.8 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016668 +name: oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] +xref: EC:1.8.1 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016669 +name: oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT [] +xref: EC:1.8.2 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016670 +name: oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT [] +xref: EC:1.8.3 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016671 +name: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.8.4 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016672 +name: oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] +xref: EC:1.8.5 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016673 +name: oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.8.7 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0016674 +name: oxidoreductase activity, acting on sulfur group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016667 + +[Term] +id: GO:0016675 +name: oxidoreductase activity, acting on heme group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] +synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] +xref: EC:1.9 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016676 +name: oxidoreductase activity, acting on heme group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] +xref: EC:1.9. +is_a: GO:0016675 ! oxidoreductase activity, acting on heme group of donors + +[Term] +id: GO:0016677 +name: oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl] +synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT [] +xref: EC:1.9.6 +is_a: GO:0016675 ! oxidoreductase activity, acting on heme group of donors + +[Term] +id: GO:0016678 +name: oxidoreductase activity, acting on heme group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016675 + +[Term] +id: GO:0016679 +name: oxidoreductase activity, acting on diphenols and related substances as donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] +xref: EC:1.10 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016680 +name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.10.1 +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0016681 +name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +subset: gosubset_prok +xref: EC:1.10.2 +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0016682 +name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.10.3 +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0016683 +name: oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016679 + +[Term] +id: GO:0016684 +name: oxidoreductase activity, acting on peroxide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] +subset: gosubset_prok +xref: EC:1.11 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016688 +name: L-ascorbate peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ascorbate + H2O2 = dehydroascorbate + 2 H2O." [EC:1.11.1.11] +synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11] +synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] +synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11] +synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] +synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11] +xref: EC:1.11.1.11 +xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016689 +name: manganese peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O." [EC:1.11.1.13] +synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13] +synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13] +synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13] +synonym: "peroxidase-M2" RELATED [EC:1.11.1.13] +xref: EC:1.11.1.13 +xref: MetaCyc:MANGANESE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016690 +name: diarylpropane peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 = veratraldehyde + 1-(3,4-dimethylphenyl)ethane-1,2-diol + 4 H2O." [EC:1.11.1.14] +synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14] +synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14] +synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14] +synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14] +synonym: "ligninase activity" EXACT [EC:1.11.1.14] +synonym: "ligninase I activity" NARROW [EC:1.11.1.14] +synonym: "LiP activity" NARROW [EC:1.11.1.14] +xref: EC:1.11.1.14 +xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016691 +name: chloride peroxidase activity +namespace: molecular_function +alt_id: GO:0016955 +alt_id: GO:0016956 +alt_id: GO:0016957 +alt_id: GO:0016958 +def: "Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O." [EC:1.11.1.10] +subset: gosubset_prok +synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10] +synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10] +synonym: "cofactor-free chloroperoxidase activity" NARROW [] +synonym: "flavin-haem chloroperoxidase activity" NARROW [] +synonym: "flavin-heme chloroperoxidase activity" NARROW [] +synonym: "haem chloroperoxidase activity" NARROW [] +synonym: "heme chloroperoxidase activity" NARROW [] +synonym: "vanadium chloroperoxidase activity" NARROW [] +xref: EC:1.11.1.10 +xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016692 +name: NADH peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + H2O2 = NAD+ + 2 H2O." [EC:1.11.1.1] +subset: gosubset_prok +synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1] +synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1] +synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1] +synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1] +synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1] +synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1] +xref: EC:1.11.1.1 +xref: MetaCyc:NADH-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016693 +name: secretory plant peroxidase activity +namespace: molecular_function +xref: EC:1.11.1.- +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016694 +name: bacterial catalase-peroxidase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a bifunctional gene product. +is_obsolete: true +consider: GO:0004096 +consider: GO:0004601 + +[Term] +id: GO:0016695 +name: oxidoreductase activity, acting on hydrogen as donor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl] +comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW [] +xref: EC:1.12 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016696 +name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +xref: EC:1.12.1 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0016697 +name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor +namespace: molecular_function +alt_id: GO:0016698 +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl] +subset: gosubset_prok +xref: EC:1.12.2 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0016699 +name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.12.7 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0016700 +name: oxidoreductase activity, acting on hydrogen as donor, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016695 + +[Term] +id: GO:0016701 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah] +comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW [] +synonym: "oxygenase" BROAD [] +xref: EC:1.13 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016702 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.13.11 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0016703 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.13.12 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0016704 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous +namespace: molecular_function +def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016701 + +[Term] +id: GO:0016705 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] +comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW [] +xref: EC:1.14 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016706 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.11 +xref: Reactome:726 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016707 +name: gibberellin 3-beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin 20 + 2-oxoglutarate + O2 = gibberellin 1 + succinate + CO2." [EC:1.14.11.15] +synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" EXACT [EC:1.14.11.15] +synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" EXACT [EC:1.14.11.15] +synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15] +synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15] +synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15] +xref: EC:1.14.11.15 +xref: MetaCyc:GIBBERELLIN-3-BETA-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0016708 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.12 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0016709 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.13 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016710 +name: trans-cinnamate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11] +synonym: "CA4H activity" NARROW [EC:1.14.13.11] +synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.13.11] +synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.13.11] +synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.13.11] +synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.13.11] +synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] +synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.11] +synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] +xref: EC:1.14.13.11 +xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0016711 +name: flavonoid 3'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21] +synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.13.21] +synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.13.21] +synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.13.21] +synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.21] +synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.13.21] +xref: EC:1.14.13.21 +xref: MetaCyc:FLAVONOID-3'-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0016712 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.14 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016713 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT [] +xref: EC:1.14.15 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016714 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.16 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016715 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.17 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016716 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.18 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016717 +name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.19 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016718 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous +namespace: molecular_function +def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016705 + +[Term] +id: GO:0016719 +name: carotene 7,8-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30] +subset: gosubset_prok +synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30] +synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30] +xref: EC:1.14.99.30 +xref: MetaCyc:1.14.99.30-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016720 +name: delta12-fatty acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + donor-H2 + O2 = crepenynate + acceptor + H2O." [EC:1.14.99.33] +synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33] +synonym: "D12-fatty acid dehydrogenase activity" EXACT [] +synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] +synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] +synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT [] +synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33] +synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33] +xref: EC:1.14.99.33 +xref: MetaCyc:1.14.99.33-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016721 +name: oxidoreductase activity, acting on superoxide radicals as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] +subset: gosubset_prok +xref: EC:1.15 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016722 +name: oxidoreductase activity, oxidizing metal ions +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] +subset: gosubset_prok +xref: EC:1.16 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016723 +name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.16.1 +is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions + +[Term] +id: GO:0016724 +name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah] +subset: gosubset_prok +xref: EC:1.16.3 +is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions + +[Term] +id: GO:0016725 +name: oxidoreductase activity, acting on CH or CH2 groups +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW [] +xref: EC:1.17 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016726 +name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +subset: gosubset_prok +xref: EC:1.17.1 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0016727 +name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:1.17.3 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0016728 +name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT [] +xref: EC:1.17.4 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0016729 +name: oxidoreductase activity, acting on CH2 groups, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016725 + +[Term] +id: GO:0016730 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT [] +xref: EC:1.18 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016731 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +xref: EC:1.18.1 +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0016732 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.18.6 +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0016733 +name: iron-iron nitrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +comment: This term was made obsolete because it represents a cellular component. +is_obsolete: true +replaced_by: GO:0016163 +replaced_by: GO:0016611 + +[Term] +id: GO:0016734 +name: molybdenum-iron nitrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +comment: This term was made obsolete because it represents a cellular component. +is_obsolete: true +replaced_by: GO:0016163 +replaced_by: GO:0016612 + +[Term] +id: GO:0016735 +name: vanadium-iron nitrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +comment: This term was made obsolete because it represents a cellular component. +is_obsolete: true +replaced_by: GO:0016163 +replaced_by: GO:0016613 + +[Term] +id: GO:0016737 +name: oxidoreductase activity, acting on reduced flavodoxin as donor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +subset: gosubset_prok +xref: EC:1.19 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016738 +name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] +subset: gosubset_prok +xref: EC:1.19.6 +is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor + +[Term] +id: GO:0016739 +name: oxidoreductase activity, acting on other substrates +namespace: molecular_function +def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016491 + +[Term] +id: GO:0016740 +name: transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +xref: EC:2 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016741 +name: transferase activity, transferring one-carbon groups +namespace: molecular_function +def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.1 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016742 +name: hydroxymethyl-, formyl- and related transferase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:2.1.2 +is_a: GO:0004372 ! glycine hydroxymethyltransferase activity + +[Term] +id: GO:0016743 +name: carboxyl- or carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] +subset: gosubset_prok +synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] +xref: EC:2.1.3 +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups + +[Term] +id: GO:0016744 +name: transferase activity, transferring aldehyde or ketonic groups +namespace: molecular_function +alt_id: GO:0016745 +def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "transketolase or transaldolase activity" EXACT [] +xref: EC:2.2 +xref: EC:2.2.1 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016746 +name: transferase activity, transferring acyl groups +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.3 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016747 +name: transferase activity, transferring acyl groups other than amino-acyl groups +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] +subset: gosubset_prok +synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1] +xref: EC:2.3.1 +xref: Reactome:1087 +is_a: GO:0016746 ! transferase activity, transferring acyl groups + +[Term] +id: GO:0016748 +name: succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +xref: Reactome:1089 +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016749 +name: N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0016748 ! succinyltransferase activity + +[Term] +id: GO:0016750 +name: O-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016748 ! succinyltransferase activity + +[Term] +id: GO:0016751 +name: S-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0016417 ! S-acyltransferase activity +is_a: GO:0016748 ! succinyltransferase activity + +[Term] +id: GO:0016752 +name: sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0016753 +name: O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016752 ! sinapoyltransferase activity + +[Term] +id: GO:0016754 +name: sinapoylglucose-malate O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + (S)-malate = D-glucose + sinapoyl-(S)-malate." [EC:2.3.1.92] +synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92] +synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92] +synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT [] +xref: EC:2.3.1.92 +xref: MetaCyc:2.3.1.92-RXN +is_a: GO:0016753 ! O-sinapoyltransferase activity + +[Term] +id: GO:0016755 +name: transferase activity, transferring amino-acyl groups +namespace: molecular_function +def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] +subset: gosubset_prok +synonym: "aminoacyltransferase activity" EXACT [] +xref: EC:2.3.2 +is_a: GO:0016746 ! transferase activity, transferring acyl groups + +[Term] +id: GO:0016756 +name: glutathione gamma-glutamylcysteinyltransferase activity +namespace: molecular_function +alt_id: GO:0042143 +def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] +synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15] +synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15] +synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] +xref: EC:2.3.2.15 +xref: MetaCyc:2.3.2.15-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0016757 +name: transferase activity, transferring glycosyl groups +namespace: molecular_function +alt_id: GO:0016932 +def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "glycosyltransferase activity" EXACT [] +synonym: "transferase activity, transferring other glycosyl groups" NARROW [] +synonym: "transglycosidase activity" EXACT [] +synonym: "transglycosylase activity" EXACT [] +xref: EC:2.4 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016758 +name: transferase activity, transferring hexosyl groups +namespace: molecular_function +def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] +subset: gosubset_prok +synonym: "hexosyltransferase activity" EXACT [] +xref: EC:2.4.1 +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0016759 +name: cellulose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29] +subset: gosubset_prok +synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29] +xref: EC:2.4.1.- +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0016760 +name: cellulose synthase (UDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12] +subset: gosubset_prok +synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12] +synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12] +synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12] +synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12] +synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12] +synonym: "glucan synthase activity" EXACT [EC:2.4.1.12] +synonym: "GS-I" RELATED [EC:2.4.1.12] +synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] +synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] +xref: EC:2.4.1.12 +xref: MetaCyc:CELLULOSE-SYNTHASE-(UDP-FORMING)-RXN +is_a: GO:0016759 ! cellulose synthase activity +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0016761 +name: cellulose synthase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29] +synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29] +synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] +synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] +synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] +synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] +synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] +synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] +xref: EC:2.4.1.29 +xref: MetaCyc:CELLULOSE-SYNTHASE-(GDP-FORMING)-RXN +is_a: GO:0016759 ! cellulose synthase activity + +[Term] +id: GO:0016762 +name: xyloglucan:xyloglucosyl transferase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207] +synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207] +synonym: "endoxyloglucan transferase activity" EXACT [] +synonym: "xyloglucan endotransglycosylase activity" EXACT [EC:2.4.1.207] +synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207] +xref: EC:2.4.1.207 +xref: MetaCyc:2.4.1.207-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0016763 +name: transferase activity, transferring pentosyl groups +namespace: molecular_function +def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] +subset: gosubset_prok +synonym: "pentosyltransferase activity" EXACT [] +xref: EC:2.4.2 +xref: Reactome:1245 +is_a: GO:0016757 ! transferase activity, transferring glycosyl groups + +[Term] +id: GO:0016764 +name: transferase activity, transferring other glycosyl groups +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016757 + +[Term] +id: GO:0016765 +name: transferase activity, transferring alkyl or aryl (other than methyl) groups +namespace: molecular_function +alt_id: GO:0016766 +def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] +xref: EC:2.5 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016767 +name: geranylgeranyl-diphosphate geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32] +subset: gosubset_prok +synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32] +synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32] +synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32] +synonym: "PSase activity" EXACT [EC:2.5.1.32] +xref: EC:2.5.1.32 +xref: MetaCyc:2.5.1.32-RXN +is_a: GO:0004337 ! geranyltranstransferase activity + +[Term] +id: GO:0016768 +name: spermine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22] +synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22] +synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22] +synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22] +xref: EC:2.5.1.22 +xref: MetaCyc:SPERMINE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0016769 +name: transferase activity, transferring nitrogenous groups +namespace: molecular_function +def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "transferase activity, transferring other nitrogenous groups" NARROW [] +xref: EC:2.6 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016770 +name: oximinotransaminase activity +namespace: molecular_function +def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai] +xref: EC:2.6.3 +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0016771 +name: transferase activity, transferring other nitrogenous groups +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016769 + +[Term] +id: GO:0016772 +name: transferase activity, transferring phosphorus-containing groups +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. +subset: gosubset_prok +xref: EC:2.7 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016773 +name: phosphotransferase activity, alcohol group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] +subset: gosubset_prok +xref: EC:2.7.1 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016774 +name: phosphotransferase activity, carboxyl group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] +subset: gosubset_prok +xref: EC:2.7.2 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016775 +name: phosphotransferase activity, nitrogenous group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl] +subset: gosubset_prok +xref: EC:2.7.3 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016776 +name: phosphotransferase activity, phosphate group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] +subset: gosubset_prok +xref: EC:2.7.4 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016777 +name: phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers +namespace: molecular_function +xref: EC:2.7.5 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016778 +name: diphosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] +subset: gosubset_prok +xref: EC:2.7.6 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016779 +name: nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_yeast +subset: gosubset_prok +xref: EC:2.7.7 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016780 +name: phosphotransferase activity, for other substituted phosphate groups +namespace: molecular_function +def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] +subset: gosubset_prok +xref: EC:2.7.8 +xref: Reactome:1452 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016781 +name: phosphotransferase activity, paired acceptors +namespace: molecular_function +def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] +subset: gosubset_prok +xref: EC:2.7.9 +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016782 +name: transferase activity, transferring sulfur-containing groups +namespace: molecular_function +def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "transferase activity, transferring sulphur-containing groups" EXACT [] +xref: EC:2.8 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016783 +name: sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "sulphurtransferase activity" EXACT [] +xref: EC:2.8.1 +is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups + +[Term] +id: GO:0016784 +name: 3-mercaptopyruvate sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2] +subset: gosubset_prok +synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT [] +synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2] +synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2] +synonym: "mercaptopyruvate sulfurtransferase activity" EXACT [] +xref: EC:2.8.1.2 +xref: MetaCyc:MERCAPYSTRANS-RXN +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0016785 +name: transferase activity, transferring selenium-containing groups +namespace: molecular_function +def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.9 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016786 +name: selenotransferase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:2.9.1 +is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups + +[Term] +id: GO:0016787 +name: hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +xref: EC:3 +xref: Reactome:450 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016788 +name: hydrolase activity, acting on ester bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] +subset: gosubset_prok +synonym: "esterase activity" EXACT [] +xref: EC:3.1 +xref: Reactome:448 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016790 +name: thiolester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com] +subset: gosubset_prok +synonym: "thiolesterase activity" EXACT [] +xref: EC:3.1.2 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0016791 +name: phosphatase activity +namespace: molecular_function +alt_id: GO:0016302 +def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "phosphatase" RELATED [] +synonym: "phosphoric monoester hydrolase activity" EXACT [] +xref: EC:3.1.3 +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016793 +name: triphosphoric monoester hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] +subset: gosubset_prok +xref: EC:3.1.5 +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016794 +name: diphosphoric monoester hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai] +subset: gosubset_prok +xref: EC:3.1.7 +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016795 +name: phosphoric triester hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a phosphoric triester." [http://cancerweb.ncl.ac.uk/] +xref: EC:3.1.8 +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016796 +name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +subset: gosubset_prok +synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.15 +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0016797 +name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +subset: gosubset_prok +xref: EC:3.1.16 +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0016798 +name: hydrolase activity, acting on glycosyl bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] +subset: gosubset_prok +synonym: "glycosidase activity" EXACT [] +synonym: "glycosylase" NARROW [] +synonym: "N-glycosylase" NARROW [] +xref: EC:3.2 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016799 +name: hydrolase activity, hydrolyzing N-glycosyl compounds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] +subset: gosubset_prok +xref: EC:3.2.2 +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0016800 +name: hydrolase activity, hydrolyzing S-glycosyl compounds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any S-glycosyl bond." [GOC:mah] +xref: EC:3.2.3.- +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0016801 +name: hydrolase activity, acting on ether bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl] +subset: gosubset_prok +xref: EC:3.3 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016802 +name: trialkylsulfonium hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai] +subset: gosubset_prok +synonym: "thioether hydrolase activity" EXACT [] +synonym: "trialkylsulphonium hydrolase activity" EXACT [] +xref: EC:3.3.1.- +is_a: GO:0016801 ! hydrolase activity, acting on ether bonds + +[Term] +id: GO:0016803 +name: ether hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai] +subset: gosubset_prok +xref: EC:3.3.2 +is_a: GO:0016801 ! hydrolase activity, acting on ether bonds + +[Term] +id: GO:0016804 +name: prolyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +subset: gosubset_prok +synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5] +synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5] +synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] +synonym: "proline iminopeptidase activity" EXACT [] +xref: EC:3.4.11.5 +xref: MetaCyc:3.4.11.5-RXN +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0016805 +name: dipeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] +subset: gosubset_prok +xref: EC:3.4.13 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0016806 +name: dipeptidyl-peptidase and tripeptidyl-peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai] +comment: This term was made obsolete because it represents two activities. +subset: gosubset_prok +xref: EC:3.4.14 +is_obsolete: true + +[Term] +id: GO:0016807 +name: cysteine-type carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +xref: EC:3.4.18 +is_a: GO:0004180 ! carboxypeptidase activity +is_a: GO:0070004 ! cysteine-type exopeptidase activity + +[Term] +id: GO:0016808 +name: proprotein convertase activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.21.- +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0016810 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] +comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] +xref: EC:3.5 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016811 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] +subset: gosubset_prok +xref: EC:3.5.1 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016812 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] +subset: gosubset_prok +xref: EC:3.5.2 +xref: Reactome:2753 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016813 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.5.3 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016814 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.5.4 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016815 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/] +subset: gosubset_prok +xref: EC:3.5.5 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016816 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016810 + +[Term] +id: GO:0016817 +name: hydrolase activity, acting on acid anhydrides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] +subset: gosubset_prok +synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] +xref: EC:3.6 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016818 +name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] +subset: gosubset_prok +xref: EC:3.6.1 +is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides + +[Term] +id: GO:0016819 +name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai] +synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT [] +xref: EC:3.6.2 +is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides + +[Term] +id: GO:0016820 +name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah] +subset: gosubset_prok +xref: EC:3.6.3 +is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides + +[Term] +id: GO:0016821 +name: hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it incorporates process information. +is_obsolete: true +replaced_by: GO:0016817 + +[Term] +id: GO:0016822 +name: hydrolase activity, acting on acid carbon-carbon bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl] +subset: gosubset_prok +xref: EC:3.7 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016823 +name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai] +subset: gosubset_prok +xref: EC:3.7.1 +is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds + +[Term] +id: GO:0016824 +name: hydrolase activity, acting on acid halide bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl] +subset: gosubset_prok +xref: EC:3.8 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016825 +name: hydrolase activity, acting on acid phosphorus-nitrogen bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl] +xref: EC:3.9 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016826 +name: hydrolase activity, acting on acid sulfur-nitrogen bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl] +synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT [] +xref: EC:3.10 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016827 +name: hydrolase activity, acting on acid carbon-phosphorus bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl] +subset: gosubset_prok +xref: EC:3.11 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016828 +name: hydrolase activity, acting on acid sulfur-sulfur bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl] +synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT [] +xref: EC:3.12 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016829 +name: lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] +comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. +subset: goslim_candida +subset: goslim_goa +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "other lyase activity" NARROW [] +xref: EC:4 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016830 +name: carbon-carbon lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] +comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "other carbon-carbon lyase activity" NARROW [] +xref: EC:4.1 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016831 +name: carboxy-lyase activity +namespace: molecular_function +def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] +subset: gosubset_prok +synonym: "decarboxylase activity" EXACT [] +xref: EC:4.1.1 +xref: Reactome:1605 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0016832 +name: aldehyde-lyase activity +namespace: molecular_function +alt_id: GO:0016228 +def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/] +subset: gosubset_prok +synonym: "aldolase activity" BROAD [] +xref: EC:4.1.2 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0016833 +name: oxo-acid-lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl] +subset: gosubset_prok +synonym: "oxo-acid lyase activity" EXACT [] +synonym: "oxoacid lyase activity" EXACT [] +xref: EC:4.1.3 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0016834 +name: other carbon-carbon lyase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016830 + +[Term] +id: GO:0016835 +name: carbon-oxygen lyase activity +namespace: molecular_function +def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] +comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "other carbon-oxygen lyase activity" NARROW [] +xref: EC:4.2 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016836 +name: hydro-lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1] +subset: gosubset_prok +xref: EC:4.2.1 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0016837 +name: carbon-oxygen lyase activity, acting on polysaccharides +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-] +subset: gosubset_prok +xref: EC:4.2.2 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0016838 +name: carbon-oxygen lyase activity, acting on phosphates +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-] +subset: gosubset_prok +xref: EC:4.2.3 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0016839 +name: other carbon-oxygen lyase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016835 + +[Term] +id: GO:0016840 +name: carbon-nitrogen lyase activity +namespace: molecular_function +def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-] +comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "other carbon-nitrogen lyase activity" NARROW [] +xref: EC:4.3 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016841 +name: ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc] +subset: gosubset_prok +xref: EC:4.3.1 +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0016842 +name: amidine-lyase activity +namespace: molecular_function +def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc] +subset: gosubset_prok +xref: EC:4.3.2 +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0016843 +name: amine-lyase activity +namespace: molecular_function +def: "Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc] +subset: gosubset_prok +xref: EC:4.3.3 +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0016844 +name: strictosidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin." [EC:4.3.3.2] +subset: gosubset_prok +synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2] +synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2] +synonym: "STR activity" EXACT [EC:4.3.3.2] +synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2] +xref: EC:4.3.3.2 +xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0016845 +name: other carbon-nitrogen lyase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016840 + +[Term] +id: GO:0016846 +name: carbon-sulfur lyase activity +namespace: molecular_function +def: "Catalysis of the elimination of H2S or substituted H2S." [EC:4.4.-.-] +subset: gosubset_prok +synonym: "carbon-sulphur lyase activity" EXACT [] +xref: EC:4.4 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016847 +name: 1-aminocyclopropane-1-carboxylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine." [EC:4.4.1.14] +subset: gosubset_prok +synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14] +synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14] +synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] +synonym: "ACC synthase activity" EXACT [EC:4.4.1.14] +synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] +synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14] +synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14] +synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14] +xref: EC:4.4.1.14 +xref: MetaCyc:4.4.1.14-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0016848 +name: carbon-halide lyase activity +namespace: molecular_function +def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah] +subset: gosubset_prok +xref: EC:4.5 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016849 +name: phosphorus-oxygen lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] +subset: gosubset_prok +xref: EC:4.6 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016850 +name: other lyase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016829 + +[Term] +id: GO:0016851 +name: magnesium chelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+." [EC:6.6.1.1] +comment: Note that this was EC:4.99.1.1. +subset: gosubset_prok +synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1] +synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1] +synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] +synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1] +synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] +synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1] +synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1] +synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1] +synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1] +xref: EC:6.6.1.1 +is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes + +[Term] +id: GO:0016852 +name: sirohydrochlorin cobaltochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3] +subset: gosubset_prok +synonym: "anaerobic cobalt chelatase activity" EXACT [] +synonym: "CbiK" NARROW [] +synonym: "CbiX" RELATED [EC:4.99.1.3] +synonym: "CbiXS" RELATED [EC:4.99.1.3] +synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3] +synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3] +xref: EC:4.99.1.3 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016853 +name: isomerase activity +namespace: molecular_function +def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. +subset: goslim_candida +subset: goslim_goa +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "other isomerase activity" NARROW [] +xref: EC:5 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016854 +name: racemase and epimerase activity +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. +subset: gosubset_prok +synonym: "racemase and epimerase activity, acting on other compounds" NARROW [] +xref: EC:5.1 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016855 +name: racemase and epimerase activity, acting on amino acids and derivatives +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah] +subset: gosubset_prok +xref: EC:5.1.1 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0016856 +name: racemase and epimerase activity, acting on hydroxy acids and derivatives +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:5.1.2 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0016857 +name: racemase and epimerase activity, acting on carbohydrates and derivatives +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:5.1.3 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0016858 +name: racemase and epimerase activity, acting on other compounds +namespace: molecular_function +def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016854 + +[Term] +id: GO:0016859 +name: cis-trans isomerase activity +namespace: molecular_function +def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:5.2 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016860 +name: intramolecular oxidoreductase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-] +comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "intramolecular isomerase activity" EXACT [] +synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] +xref: EC:5.3 +xref: Reactome:1429 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016861 +name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl] +subset: gosubset_prok +synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT [] +xref: EC:5.3.1 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016862 +name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl] +subset: gosubset_prok +synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT [] +xref: EC:5.3.2 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016863 +name: intramolecular oxidoreductase activity, transposing C=C bonds +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah] +subset: gosubset_prok +synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT [] +xref: EC:5.3.3 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016864 +name: intramolecular oxidoreductase activity, transposing S-S bonds +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah] +subset: gosubset_prok +synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT [] +xref: EC:5.3.4 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016865 +name: intramolecular oxidoreductase activity, other intramolecular oxidoreductases +namespace: molecular_function +def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT [] +is_obsolete: true +consider: GO:0016860 + +[Term] +id: GO:0016866 +name: intramolecular transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] +comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "intramolecular transferase activity, transferring other groups" NARROW [] +synonym: "mutase activity" EXACT [] +xref: EC:5.4 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016867 +name: intramolecular transferase activity, transferring acyl groups +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:5.4.1 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0016868 +name: intramolecular transferase activity, phosphotransferases +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] +subset: gosubset_prok +synonym: "phosphomutase activity" EXACT [] +xref: EC:5.4.2 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0016869 +name: intramolecular transferase activity, transferring amino groups +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:5.4.3 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0016870 +name: intramolecular transferase activity, transferring other groups +namespace: molecular_function +def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016866 + +[Term] +id: GO:0016871 +name: cycloartenol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8] +subset: gosubset_prok +synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8] +synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8] +synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8] +synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] +synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581] +synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] +xref: EC:5.4.99.8 +xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0016872 +name: intramolecular lyase activity +namespace: molecular_function +def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/] +subset: gosubset_prok +xref: EC:5.5 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016873 +name: other isomerase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016853 + +[Term] +id: GO:0016874 +name: ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_goa +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +xref: EC:6 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016875 +name: ligase activity, forming carbon-oxygen bonds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +xref: EC:6.1 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016876 +name: ligase activity, forming aminoacyl-tRNA and related compounds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound." [GOC:jl] +subset: gosubset_prok +xref: EC:6.1.1 +is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds + +[Term] +id: GO:0016877 +name: ligase activity, forming carbon-sulfur bonds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] +xref: EC:6.2 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016878 +name: acid-thiol ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +xref: EC:6.2.1 +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0016879 +name: ligase activity, forming carbon-nitrogen bonds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term. +subset: gosubset_prok +synonym: "other carbon-nitrogen ligase activity" NARROW [] +xref: EC:6.3 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016880 +name: acid-ammonia (or amide) ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +synonym: "amide synthase activity" EXACT [] +xref: EC:6.3.1 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016881 +name: acid-amino acid ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +synonym: "peptide synthase activity" EXACT [] +xref: EC:6.3.2 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016882 +name: cyclo-ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a carbon-nitrogen bond to form a heterocyclic product, with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:mah] +subset: gosubset_prok +xref: EC:6.3.3 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016883 +name: other carbon-nitrogen ligase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016879 + +[Term] +id: GO:0016884 +name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor +namespace: molecular_function +alt_id: GO:0016003 +def: "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532] +subset: gosubset_prok +xref: EC:6.3.5 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016885 +name: ligase activity, forming carbon-carbon bonds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +xref: EC:6.4 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016886 +name: ligase activity, forming phosphoric ester bonds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +subset: gosubset_prok +xref: EC:6.5 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016887 +name: ATPase activity +namespace: molecular_function +alt_id: GO:0004002 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] +synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] +synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] +synonym: "adenosinetriphosphatase activity" EXACT [] +synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] +synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] +synonym: "ATP phosphohydrolase activity" EXACT [] +synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3] +synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] +synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0016888 +name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] +subset: gosubset_prok +synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.21 +is_a: GO:0004520 ! endodeoxyribonuclease activity +is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016889 +name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] +subset: gosubset_prok +synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] +xref: EC:3.1.22 +is_a: GO:0004520 ! endodeoxyribonuclease activity +is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + +[Term] +id: GO:0016890 +name: site-specific endodeoxyribonuclease activity, specific for altered base +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl] +subset: gosubset_prok +xref: EC:3.1.25 +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0016891 +name: endoribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] +subset: gosubset_prok +xref: EC:3.1.26 +is_a: GO:0004521 ! endoribonuclease activity +is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016892 +name: endoribonuclease activity, producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] +subset: gosubset_prok +synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] +xref: EC:3.1.27 +is_a: GO:0004521 ! endoribonuclease activity +is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + +[Term] +id: GO:0016893 +name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +subset: gosubset_prok +synonym: "5'-endonuclease activity" EXACT [] +synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED [] +xref: EC:3.1.30 +is_a: GO:0004519 ! endonuclease activity + +[Term] +id: GO:0016894 +name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +subset: gosubset_prok +synonym: "3'-endonuclease activity" EXACT [] +synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] +xref: EC:3.1.31 +is_a: GO:0004519 ! endonuclease activity + +[Term] +id: GO:0016895 +name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] +subset: gosubset_prok +synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.11 +is_a: GO:0004529 ! exodeoxyribonuclease activity +is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016896 +name: exoribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] +subset: gosubset_prok +synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.13 +is_a: GO:0004532 ! exoribonuclease activity +is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016897 +name: exoribonuclease activity, producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai] +xref: EC:3.1.14 +is_a: GO:0004532 ! exoribonuclease activity +is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + +[Term] +id: GO:0016898 +name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:1.1.2 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016899 +name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:1.1.3 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016900 +name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.1.4 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016901 +name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] +subset: gosubset_prok +xref: EC:1.1.5 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016902 +name: oxidoreductase activity, acting on the CH-OH group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0016614 + +[Term] +id: GO:0016903 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] +xref: EC:1.2 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016905 +name: myosin heavy chain kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] +synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] +synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] +synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7] +synonym: "MHCK" RELATED [EC:2.7.11.7] +synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7] +synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7] +synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7] +synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7] +synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] +synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7] +synonym: "STK6" RELATED [EC:2.7.11.7] +xref: EC:2.7.11.7 +xref: MetaCyc:MYOSIN-HEAVY-CHAIN-KINASE-RXN +is_a: GO:0004683 ! calmodulin-dependent protein kinase activity + +[Term] +id: GO:0016906 +name: sterol 3-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173] +synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "sterol glucosyltransferase activity" EXACT [] +synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "sterol:UDPG glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT [] +synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173] +synonym: "UDPG:sterol glucosyltransferase activity" EXACT [] +synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173] +synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] +xref: EC:2.4.1.173 +xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0016907 +name: G-protein coupled acetylcholine receptor activity +namespace: molecular_function +synonym: "G protein coupled acetylcholine receptor activity" EXACT [] +synonym: "G-protein-coupled acetylcholine receptor activity" EXACT [] +is_a: GO:0008227 ! amine receptor activity +is_a: GO:0015464 ! acetylcholine receptor activity + +[Term] +id: GO:0016908 +name: MAP kinase 2 activity +namespace: molecular_function +synonym: "ERK2" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004707 ! MAP kinase activity + +[Term] +id: GO:0016909 +name: SAP kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma] +synonym: "SAPK" EXACT [] +synonym: "stress-activated kinase activity" EXACT [] +synonym: "stress-activated protein kinase activity" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004707 ! MAP kinase activity + +[Term] +id: GO:0016910 +name: SAP kinase 3 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a gene product. +synonym: "SAPK3" EXACT [] +is_obsolete: true +consider: GO:0004674 +consider: GO:0004871 +consider: GO:0007254 + +[Term] +id: GO:0016911 +name: SAP kinase 4 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a gene product. +synonym: "SAPK4" EXACT [] +is_obsolete: true +consider: GO:0004674 +consider: GO:0004871 +consider: GO:0007254 + +[Term] +id: GO:0016912 +name: SAP kinase 5 activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product. +synonym: "SAPK5" EXACT [] +is_obsolete: true +consider: GO:0004674 +consider: GO:0004871 +consider: GO:0007254 + +[Term] +id: GO:0016913 +name: follicle-stimulating hormone activity +namespace: molecular_function +def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland." [ISBN:0198547684] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016914 +name: follicle-stimulating hormone complex +namespace: cellular_component +def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0016915 +name: activin +namespace: molecular_function +def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005160 +consider: GO:0046881 + +[Term] +id: GO:0016916 +name: inhibin +namespace: molecular_function +def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005160 +consider: GO:0046882 + +[Term] +id: GO:0016917 +name: GABA receptor activity +namespace: molecular_function +def: "Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity." [GOC:jl, http://cancerweb.ncl.ac.uk/] +comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. +synonym: "4-aminobutanoate receptor activity" EXACT [] +synonym: "4-aminobutyrate receptor activity" EXACT [] +synonym: "GABA binding" EXACT [] +synonym: "gamma-aminobutyrate binding" EXACT [] +synonym: "gamma-aminobutyric acid binding" EXACT [] +synonym: "gamma-aminobutyric acid receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0016918 +name: retinal binding +namespace: molecular_function +def: "Interacting selectively with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "blue-sensitive opsin" RELATED [] +synonym: "green-sensitive opsin" RELATED [] +synonym: "long-wave-sensitive opsin" RELATED [] +synonym: "opsin" RELATED [] +synonym: "red-sensitive opsin" RELATED [] +synonym: "retinaldehyde binding" EXACT [] +synonym: "short-wave-sensitive opsin" RELATED [] +synonym: "UV-sensitive opsin" RELATED [] +synonym: "violet-sensitive opsin" RELATED [] +synonym: "vitamin A binding" BROAD [] +is_a: GO:0005501 ! retinoid binding +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0016919 +name: nardilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61] +comment: This term was made obsolete because it represents a gene product. +synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61] +synonym: "NRD convertase activity" EXACT [EC:3.4.24.61] +synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61] +xref: EC:3.4.24.61 +xref: MetaCyc:3.4.24.61-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0016920 +name: pyroglutamyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah] +subset: gosubset_prok +xref: EC:3.4.19.- +is_a: GO:0008242 ! omega peptidase activity + +[Term] +id: GO:0016921 +name: pyroglutamyl-peptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6] +comment: This term was made obsolete because it represents a gene product. +synonym: "PAP-II activity" EXACT [EC:3.4.19.6] +synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6] +synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6] +synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6] +synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] +synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6] +synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] +synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6] +synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6] +synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] +synonym: "TRH-DE activity" NARROW [EC:3.4.19.6] +synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6] +synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6] +xref: EC:3.4.19.6 +xref: MetaCyc:3.4.19.6-RXN +is_obsolete: true +replaced_by: GO:0008237 +replaced_by: GO:0016920 + +[Term] +id: GO:0016922 +name: ligand-dependent nuclear receptor binding +namespace: molecular_function +def: "Interacting selectively, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] +synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0016923 +name: ligand-dependent thyroid hormone receptor interactor activity +namespace: molecular_function +def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "TRIP4" RELATED [] +is_obsolete: true +consider: GO:0046966 + +[Term] +id: GO:0016925 +name: protein sumoylation +namespace: biological_process +alt_id: GO:0006485 +alt_id: GO:0016927 +def: "The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] +synonym: "protein sumolation" EXACT [] +synonym: "small ubiquitin-related protein 1 conjugation" EXACT [] +synonym: "SUMO-protein conjugation" EXACT [] +synonym: "sumoylation" EXACT [] +is_a: GO:0032446 ! protein modification by small protein conjugation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0016926 +name: protein desumoylation +namespace: biological_process +alt_id: GO:0016928 +def: "The process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] +synonym: "desumoylation" EXACT [] +synonym: "protein desumolation" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0016929 +name: SUMO-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] +synonym: "SUSP" NARROW [] +synonym: "ULP" NARROW [] +is_a: GO:0019783 ! small conjugating protein-specific protease activity + +[Term] +id: GO:0016931 +name: vasopressin activated calcium mobilizing receptor activity +namespace: molecular_function +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0016933 +name: extracellular-glycine-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "glycine receptor" BROAD [] +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity + +[Term] +id: GO:0016934 +name: extracellular-glycine-gated chloride channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "glycine receptor" BROAD [] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0016933 ! extracellular-glycine-gated ion channel activity + +[Term] +id: GO:0016935 +name: glycine-gated chloride channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah] +is_a: GO:0034707 ! chloride channel complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0016936 +name: galactoside binding +namespace: molecular_function +def: "Interacting selectively with any glycoside in which the sugar moiety is galactose." [ChEBI:24163, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0016937 +name: short-branched-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +xref: EC:1.3.99.- +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0016938 +name: kinesin I complex +namespace: cellular_component +def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0016939 +name: kinesin II complex +namespace: cellular_component +def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0016941 +name: natriuretic peptide receptor activity +namespace: molecular_function +is_a: GO:0001653 ! peptide receptor activity + +[Term] +id: GO:0016942 +name: insulin-like growth factor binding protein complex +namespace: cellular_component +def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl] +subset: goslim_pir +synonym: "IGF binding protein complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0016943 +name: RNA polymerase I transcription elongation factor activity +namespace: molecular_function +def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah] +synonym: "Pol I transcription elongation factor activity" EXACT [] +is_a: GO:0003711 ! transcription elongation regulator activity + +[Term] +id: GO:0016944 +name: RNA polymerase II transcription elongation factor activity +namespace: molecular_function +def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah] +synonym: "Pol II transcription elongation factor activity" EXACT [] +is_a: GO:0003711 ! transcription elongation regulator activity + +[Term] +id: GO:0016945 +name: RNA polymerase III transcription elongation factor activity +namespace: molecular_function +def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah] +synonym: "Pol III transcription elongation factor activity" EXACT [] +is_a: GO:0003711 ! transcription elongation regulator activity + +[Term] +id: GO:0016946 +name: cathepsin F activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] +comment: This term was made obsolete because it represents a gene product. +xref: EC:3.4.22.41 +xref: MetaCyc:3.4.22.41-RXN +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0016959 +name: class I ribonucleotide reductase activity +namespace: molecular_function +synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" EXACT [] +xref: Reactome:4419 +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0016960 +name: class II ribonucleotide reductase activity +namespace: molecular_function +synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" EXACT [] +synonym: "class II ribonucleoside-diphosphate reductase activity" EXACT [] +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0016961 +name: class III ribonucleotide reductase activity +namespace: molecular_function +synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" EXACT [] +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0016962 +name: receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0016963 +name: alpha-2 macroglobulin receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [UniProtKB:P30533] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0016964 +name: alpha-2 macroglobulin receptor activity +namespace: molecular_function +def: "Combining with an alpha-2 macroglobulin to initiate a change in cell activity." [GOC:ma] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0016966 +name: nitric oxide reductase activity +namespace: molecular_function +alt_id: GO:0016967 +alt_id: GO:0016968 +def: "Catalysis of the reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor." [EC:1.7.99.7, MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "CYP55" NARROW [] +synonym: "cytochrome bc nitric oxide reductase activity" NARROW [] +synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.99.7] +synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.99.7] +synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7] +synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7] +synonym: "P450 nitric oxide reductase activity" NARROW [] +synonym: "P450nor" NARROW [] +xref: EC:1.7.99.7 +xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016969 +name: hemerythrin +namespace: molecular_function +def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0005344 + +[Term] +id: GO:0016970 +name: hemocyanin +namespace: molecular_function +def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0005344 + +[Term] +id: GO:0016971 +name: flavin-linked sulfhydryl oxidase activity +namespace: molecular_function +def: "Catalysis of the formation of disulfide bridges." [PMID:10899311] +is_a: GO:0016972 ! thiol oxidase activity + +[Term] +id: GO:0016972 +name: thiol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2] +synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2] +synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2] +xref: EC:1.8.3.2 +xref: MetaCyc:THIOL-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0808 +is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0016973 +name: poly(A)+ mRNA export from nucleus +namespace: biological_process +def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai] +synonym: "poly(A) mRNA export from nucleus" EXACT [] +synonym: "poly(A)+ mRNA export from cell nucleus" EXACT [] +synonym: "poly(A)+ mRNA export out of nucleus" EXACT [] +synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "poly(A)+ mRNA-nucleus export" EXACT [] +is_a: GO:0006406 ! mRNA export from nucleus + +[Term] +id: GO:0016974 +name: sodium channel auxiliary protein activity +namespace: molecular_function +is_a: GO:0015457 ! auxiliary transport protein activity + +[Term] +id: GO:0016975 +name: alpha-2 macroglobulin +namespace: molecular_function +def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004866 + +[Term] +id: GO:0016977 +name: chitosanase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132] +subset: gosubset_prok +synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132] +xref: EC:3.2.1.132 +xref: MetaCyc:3.2.1.132-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016979 +name: lipoate-protein ligase activity +namespace: molecular_function +alt_id: GO:0008916 +alt_id: GO:0016978 +def: "Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [EC:6.3.4.-] +subset: gosubset_prok +synonym: "lipoate-protein ligase A activity" NARROW [] +synonym: "lipoate-protein ligase B activity" NARROW [] +xref: EC:6.3.4.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016980 +name: creatinase activity +namespace: molecular_function +def: "Catalysis of the reaction: creatine + H2O = sarcosine + urea." [EC:3.5.3.3] +subset: gosubset_prok +synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3] +xref: EC:3.5.3.3 +xref: MetaCyc:CREATINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0016983 +name: cytokine beta-glucosidase activity +namespace: molecular_function +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0016984 +name: ribulose-bisphosphate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39] +subset: gosubset_prok +synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39] +synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39] +synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39] +synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT [] +synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] +synonym: "rubisco activity" EXACT [] +synonym: "RuBisCO activity" EXACT [EC:4.1.1.39] +synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39] +xref: EC:4.1.1.39 +xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0016985 +name: mannan endo-1,4-beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 1,4-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] +subset: gosubset_prok +synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78] +synonym: "beta-1, 4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78] +synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78] +synonym: "beta-mannanase activity" EXACT [EC:3.2.1.78] +synonym: "beta-mannanase B" RELATED [EC:3.2.1.78] +synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78] +synonym: "endo-1,4-mannanase activity" EXACT [EC:3.2.1.78] +synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78] +synonym: "endo-beta-mannanase activity" EXACT [EC:3.2.1.78] +xref: EC:3.2.1.78 +xref: MetaCyc:3.2.1.78-RXN +is_a: GO:0004567 ! beta-mannosidase activity + +[Term] +id: GO:0016986 +name: transcription initiation factor activity +namespace: molecular_function +subset: gosubset_prok +synonym: "transcriptional initiation factor activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0016987 +name: sigma factor activity +namespace: molecular_function +def: "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc] +subset: gosubset_prok +synonym: "sigma transcription factor" RELATED [] +is_a: GO:0016986 ! transcription initiation factor activity + +[Term] +id: GO:0016988 +name: transcription initiation factor antagonist activity +namespace: molecular_function +def: "The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl] +subset: gosubset_prok +synonym: "transcriptional initiation factor antagonist activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0016989 +name: sigma factor antagonist activity +namespace: molecular_function +def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, http://en.wikipedia.org/wiki/Anti-sigma_factors] +subset: gosubset_prok +synonym: "anti-sigma factor activity" EXACT [] +is_a: GO:0016988 ! transcription initiation factor antagonist activity + +[Term] +id: GO:0016990 +name: arginine deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6] +subset: gosubset_prok +synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6] +synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6] +synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6] +synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6] +xref: EC:3.5.3.6 +xref: MetaCyc:ARGININE-DEIMINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0016992 +name: lipoate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8] +subset: gosubset_prok +synonym: "LipA" RELATED [EC:2.8.1.8] +synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8] +synonym: "LS" RELATED [EC:2.8.1.8] +synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] +synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] +xref: EC:2.8.1.8 +is_a: GO:0016783 ! sulfurtransferase activity +is_a: GO:0016979 ! lipoate-protein ligase activity + +[Term] +id: GO:0016993 +name: precorrin-8X methylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.1.2] +subset: gosubset_prok +synonym: "HBA synthase activity" EXACT [EC:5.4.1.2] +synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.1.2] +synonym: "precorrin isomerase activity" EXACT [EC:5.4.1.2] +synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [EC:5.4.1.2] +xref: EC:5.4.1.2 +xref: MetaCyc:5.4.1.2-RXN +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0016994 +name: precorrin-6A reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54] +subset: gosubset_prok +synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] +synonym: "precorrin-6X reductase activity" EXACT [] +synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54] +synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] +xref: EC:1.3.1.54 +xref: MetaCyc:1.3.1.54-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016995 +name: cholesterol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + O2 = cholest-4-en-3-one + H2O2." [EC:1.1.3.6] +synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6] +synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] +synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6] +synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6] +synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6] +synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] +xref: EC:1.1.3.6 +xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0016996 +name: endo-alpha-sialidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129] +synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] +synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] +synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129] +synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129] +synonym: "endosialidase activity" EXACT [EC:3.2.1.129] +synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] +synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] +synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129] +xref: EC:3.2.1.129 +xref: MetaCyc:3.2.1.129-RXN +is_a: GO:0016997 ! alpha-sialidase activity + +[Term] +id: GO:0016997 +name: alpha-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah] +subset: gosubset_prok +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016998 +name: cell wall catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cell wall." [GOC:go_curators] +subset: gosubset_prok +synonym: "cell wall breakdown" EXACT [] +synonym: "cell wall catabolism" EXACT [] +synonym: "cell wall degradation" EXACT [] +is_a: GO:0010382 ! cell wall metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0016999 +name: antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] +subset: gosubset_prok +synonym: "antibiotic metabolism" EXACT [] +is_a: GO:0017144 ! drug metabolic process + +[Term] +id: GO:0017000 +name: antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] +subset: gosubset_prok +synonym: "antibiotic anabolism" EXACT [] +synonym: "antibiotic biosynthesis" EXACT [] +synonym: "antibiotic formation" EXACT [] +synonym: "antibiotic synthesis" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0017001 +name: antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] +subset: gosubset_prok +synonym: "antibiotic breakdown" EXACT [] +synonym: "antibiotic catabolism" EXACT [] +synonym: "antibiotic degradation" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0017002 +name: activin receptor activity +namespace: molecular_function +def: "Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005024 ! transforming growth factor beta receptor activity + +[Term] +id: GO:0017003 +name: protein-heme linkage +namespace: biological_process +def: "The covalent linkage of heme and a protein." [GOC:ma] +subset: gosubset_prok +synonym: "protein-haem linkage" EXACT [] +is_a: GO:0017006 ! protein-tetrapyrrole linkage + +[Term] +id: GO:0017004 +name: cytochrome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah] +subset: gosubset_prok +synonym: "cytochrome biogenesis" BROAD [] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0017005 +name: tyrosyl-DNA phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354] +comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0017006 +name: protein-tetrapyrrole linkage +namespace: biological_process +def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0017007 +name: protein-bilin linkage +namespace: biological_process +def: "The covalent linkage of bilin and a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0017006 ! protein-tetrapyrrole linkage + +[Term] +id: GO:0017008 +name: protein-phycobiliviolin linkage +namespace: biological_process +def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258] +subset: gosubset_prok +xref: RESID:AA0258 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017009 +name: protein-phycocyanobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131] +subset: gosubset_prok +xref: RESID:AA0131 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017010 +name: protein-phycourobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260] +subset: gosubset_prok +xref: RESID:AA0260 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017011 +name: protein-phycoerythrobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259] +subset: gosubset_prok +xref: RESID:AA0132 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017012 +name: protein-phytochromobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133] +subset: gosubset_prok +xref: RESID:AA0133 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017013 +name: protein amino acid flavinylation +namespace: biological_process +def: "The addition of a flavin group to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0017014 +name: protein amino acid nitrosylation +namespace: biological_process +def: "The addition of a nitrosyl group to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0017015 +name: regulation of transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] +synonym: "regulation of TGF-beta receptor signaling pathway" EXACT [] +synonym: "regulation of TGFbeta receptor signaling pathway" EXACT [] +synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0017016 +name: Ras GTPase binding +namespace: molecular_function +def: "Interacting selectively with any member of the Ras superfamily of monomeric GTPases." [GOC:mah] +synonym: "Ras interactor activity" RELATED [] +is_a: GO:0031267 ! small GTPase binding + +[Term] +id: GO:0017017 +name: MAP kinase tyrosine/serine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] +synonym: "dual-specificity MAP kinase phosphatase activity" EXACT [] +xref: EC:3.1.3.- +is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity +is_a: GO:0033549 ! MAP kinase phosphatase activity + +[Term] +id: GO:0017018 +name: myosin phosphatase activity +namespace: molecular_function +alt_id: GO:0017019 +def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] +synonym: "myosin phosphatase myosin binding" RELATED [] +synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT [] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0017020 +name: myosin phosphatase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai] +synonym: "myosin phosphatase, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0017021 +name: myosin phosphatase myosin binding +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function. +is_obsolete: true +consider: GO:0017018 +consider: GO:0017022 + +[Term] +id: GO:0017022 +name: myosin binding +namespace: molecular_function +def: "Interacting selectively with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +synonym: "myosin phosphatase myosin binding" NARROW [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0017023 +name: myosin phosphatase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex + +[Term] +id: GO:0017024 +name: myosin I binding +namespace: molecular_function +def: "Interacting selectively with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0017025 +name: TATA-binding protein binding +namespace: molecular_function +def: "Interacting selectively with TATA-binding protein (TBP), a component of various transcription factors." [GOC:jl, http://www.mblab.gla.ac.uk/] +synonym: "TBP binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0017026 +name: procollagen C-endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19] +comment: This term was made obsolete because it represents a gene product. +synonym: "BMP1" NARROW [] +synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19] +synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19] +synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19] +synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19] +synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19] +synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19] +synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19] +xref: EC:3.4.24.19 +xref: MetaCyc:3.4.24.19-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0017027 +name: transmembrane receptor protein serine/threonine kinase receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0017028 +name: protein stabilization activity +namespace: molecular_function +def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jic, http://biotech.icmb.utexas.edu] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0050821 + +[Term] +id: GO:0017029 +name: lysosomal protein stabilization +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +is_obsolete: true +consider: GO:0005764 +consider: GO:0050821 + +[Term] +id: GO:0017030 +name: beta-galactosidase stabilization activity +namespace: molecular_function +def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0050821 + +[Term] +id: GO:0017032 +name: potassium:amino acid symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai] +synonym: "potassium:amino acid transporter activity" BROAD [] +is_a: GO:0005416 ! cation:amino acid symporter activity + +[Term] +id: GO:0017033 +name: DNA topoisomerase I binding +namespace: molecular_function +def: "Interacting selectively with the enzyme DNA topoisomerase I." [GOC:ai] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0017034 +name: Rap guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0017038 +name: protein import +namespace: biological_process +def: "The directed movement of proteins into a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "protein uptake" EXACT [] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0017039 +name: dipeptidyl-peptidase III activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4] +synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4] +synonym: "DPP III activity" EXACT [EC:3.4.14.4] +synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] +synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] +xref: EC:3.4.14.4 +xref: MetaCyc:3.4.14.4-RXN +is_obsolete: true +replaced_by: GO:0008239 + +[Term] +id: GO:0017040 +name: ceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] +subset: gosubset_prok +synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23] +synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23] +synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23] +xref: EC:3.5.1.23 +xref: MetaCyc:CERAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0017041 +name: galactosylgalactosylglucosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47] +synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47] +synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47] +synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47] +synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47] +synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47] +synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47] +xref: EC:3.2.1.47 +xref: MetaCyc:3.2.1.47-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0017040 ! ceramidase activity + +[Term] +id: GO:0017042 +name: glycosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62] +synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62] +synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62] +synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62] +synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62] +synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62] +synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62] +synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62] +synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62] +xref: EC:3.2.1.62 +xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0017040 ! ceramidase activity + +[Term] +id: GO:0017043 +name: adrenocorticotropin +namespace: molecular_function +def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +synonym: "corticotropin" BROAD [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0046886 +consider: GO:0046887 + +[Term] +id: GO:0017044 +name: alpha-melanocyte stimulating hormone activity +namespace: molecular_function +synonym: "alpha-melanophore stimulating hormone activity" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0017045 +name: adrenocorticotropin-releasing hormone activity +namespace: molecular_function +synonym: "corticotropin-releasing hormone" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0017046 +name: peptide hormone binding +namespace: molecular_function +def: "Interacting selectively with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "polypeptide hormone binding" EXACT [] +is_a: GO:0042277 ! peptide binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0017047 +name: adrenocorticotropin-releasing hormone binding +namespace: molecular_function +def: "Interacting selectively with adrenocorticotropin-releasing hormone." [GOC:jl] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0017048 +name: Rho GTPase binding +namespace: molecular_function +alt_id: GO:0017031 +def: "Interacting selectively with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856] +synonym: "Rho interactor activity" RELATED [] +synonym: "Rhophilin" NARROW [] +is_a: GO:0017016 ! Ras GTPase binding + +[Term] +id: GO:0017049 +name: GTP-Rho binding +namespace: molecular_function +def: "Interacting selectively with the GTP-bound form of the Rho protein." [GOC:mah] +is_a: GO:0017048 ! Rho GTPase binding + +[Term] +id: GO:0017050 +name: D-erythro-sphingosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [UniProtKB:Q9JIA7] +synonym: "sphingosine kinase activity" EXACT [] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0017051 +name: retinol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0017052 +name: insulin-like growth factor binding protein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +consider: GO:0016942 + +[Term] +id: GO:0017053 +name: transcriptional repressor complex +namespace: cellular_component +def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0017054 +name: negative cofactor 2 complex +namespace: cellular_component +def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413] +is_a: GO:0017053 ! transcriptional repressor complex + +[Term] +id: GO:0017055 +name: negative regulation of transcriptional preinitiation complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcriptional preinitiation complex assembly." [GOC:go_curators] +synonym: "down regulation of transcriptional preinitiation complex assembly" EXACT [] +synonym: "down-regulation of transcriptional preinitiation complex assembly" EXACT [] +synonym: "downregulation of transcriptional preinitiation complex assembly" EXACT [] +synonym: "inhibition of transcriptional preinitiation complex assembly" NARROW [] +synonym: "negative regulation of transcriptional pre-initiation complex assembly" EXACT [] +synonym: "negative regulation of transcriptional pre-initiation complex biosynthesis" EXACT [] +synonym: "negative regulation of transcriptional preinitiation complex formation" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0045898 ! regulation of transcriptional preinitiation complex assembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0051123 ! transcriptional preinitiation complex assembly + +[Term] +id: GO:0017056 +name: structural constituent of nuclear pore +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0017057 +name: 6-phosphogluconolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate." [EC:3.1.1.31] +subset: gosubset_prok +synonym: "6-PGL" RELATED [EC:3.1.1.31] +synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31] +synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31] +xref: EC:3.1.1.31 +xref: MetaCyc:6PGLUCONOLACT-RXN +xref: Reactome:25159 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0017058 +name: FH1 domain binding +namespace: molecular_function +def: "Interacting selectively with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0017059 +name: serine C-palmitoyltransferase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50] +is_a: GO:0031211 ! palmitoyltransferase complex + +[Term] +id: GO:0017060 +name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65] +synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] +synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "alpha(1,3/1,4) fucosyltransferase III" RELATED [EC:2.4.1.65] +synonym: "alpha(1,4)-L-fucosyltransferase activity" EXACT [] +synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" EXACT [EC:2.4.1.65] +synonym: "alpha-(1->4)-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "alpha-4-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "blood group Lewis alpha-4-fucosyltransferase" NARROW [EC:2.4.1.65] +synonym: "blood group Lewis alpha-4-fucosyltransferase activity" NARROW [EC:2.4.1.65] +synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" NARROW [EC:2.4.1.65] +synonym: "blood-group substance Lea-dependent fucosyltransferase" NARROW [EC:2.4.1.65] +synonym: "FucT-II activity" EXACT [EC:2.4.1.65] +synonym: "galactoside 3(4)-L-fucosyltransferase activity" EXACT [] +synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] +synonym: "Lewis alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65] +synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] +synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65] +synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65] +synonym: "Lewis FT activity" NARROW [EC:2.4.1.65] +synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase" NARROW [EC:2.4.1.65] +synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65] +xref: EC:2.4.1.65 +xref: MetaCyc:2.4.1.65-RXN +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0017061 +name: S-methyl-5-thioadenosine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28] +subset: gosubset_prok +synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] +synonym: "5'-methylthioadenosine phosphorylase activity" EXACT [] +synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] +synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28] +synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28] +synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28] +synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] +synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28] +synonym: "MTAPase activity" EXACT [EC:2.4.2.28] +synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] +xref: EC:2.4.2.28 +xref: MetaCyc:5'-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0017062 +name: cytochrome bc(1) complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/] +subset: gosubset_prok +synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT [] +synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT [] +synonym: "complex III assembly" EXACT [] +synonym: "complex III biogenesis" EXACT [] +synonym: "cytochrome bc(1) complex biogenesis" EXACT [] +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0017063 +name: phosphatidylserine-specific phospholipase A1 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32] +is_a: GO:0008970 ! phospholipase A1 activity + +[Term] +id: GO:0017064 +name: fatty acid amide hydrolase activity +namespace: molecular_function +alt_id: GO:0017073 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0017065 +name: single-strand selective uracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623] +synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT [] +xref: EC:3.2.2.- +xref: Reactome:25182 +is_a: GO:0004844 ! uracil DNA N-glycosylase activity + +[Term] +id: GO:0017067 +name: tyrosine-ester sulfotransferase activity +namespace: molecular_function +alt_id: GO:0008128 +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate." [EC:2.8.2.9] +synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9] +synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9] +synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9] +synonym: "tyrosine-ester sulphotransferase activity" EXACT [] +xref: EC:2.8.2.9 +xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0017069 +name: snRNA binding +namespace: molecular_function +def: "Interacting selectively with a small nuclear RNA (snRNA)." [GOC:mah] +synonym: "small nuclear RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0017070 +name: U6 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] +comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0017071 +name: intracellular cyclic nucleotide activated cation channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0017072 +name: tubulin-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227] +comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. +is_obsolete: true +consider: GO:0006461 +consider: GO:0007021 +consider: GO:0051082 + +[Term] +id: GO:0017074 +name: procollagen N-endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14] +synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14] +synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14] +synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14] +synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14] +synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14] +synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14] +synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14] +synonym: "type III procollagen" RELATED [EC:3.4.24.14] +xref: EC:3.4.24.14 +xref: MetaCyc:3.4.24.14-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0017075 +name: syntaxin-1 binding +namespace: molecular_function +def: "Interacting selectively with the SNAP receptor syntaxin-1." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0017076 +name: purine nucleotide binding +namespace: molecular_function +def: "Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0017077 +name: oxidative phosphorylation uncoupler activity +namespace: molecular_function +alt_id: GO:0015302 +def: "Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945] +synonym: "mitochondrial uncoupling protein activity" NARROW [] +synonym: "uncoupling protein activity" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0017078 +name: Hsc70 protein regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403] +synonym: "Hsc70 interacting protein" BROAD [] +is_a: GO:0030192 ! Hsp70/Hsc70 protein regulator activity +is_a: GO:0030544 ! Hsp70 protein binding + +[Term] +id: GO:0017080 +name: sodium channel regulator activity +namespace: molecular_function +is_a: GO:0016247 ! channel regulator activity + +[Term] +id: GO:0017081 +name: chloride channel regulator activity +namespace: molecular_function +is_a: GO:0016247 ! channel regulator activity + +[Term] +id: GO:0017082 +name: mineralocorticoid receptor activity +namespace: molecular_function +def: "Combining with mineralocorticoid to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0017083 +name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152] +synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "galactoside 3-L-fucosyltransferase activity" EXACT [] +synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152] +synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] +synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] +xref: EC:2.4.1.152 +xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN +is_a: GO:0046920 ! alpha(1,3)-fucosyltransferase activity + +[Term] +id: GO:0017084 +name: delta1-pyrroline-5-carboxylate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] +synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0017085 +name: response to insecticide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "insecticide resistance" RELATED [] +synonym: "insecticide susceptibility/resistance" RELATED [] +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0017086 +name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex +namespace: cellular_component +alt_id: GO:0031212 +def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamin diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4] +synonym: "BCADH" EXACT [] +synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0017087 +name: mitochondrial processing peptidase complex +namespace: cellular_component +def: "This enzyme complex catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [EC:3.4.24.64] +is_a: GO:0043234 ! protein complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0017088 +name: X-Pro dipeptidyl-peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "PepX" RELATED [EC:3.4.14.11] +synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11] +synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11] +synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] +xref: EC:3.4.14.11 +xref: MetaCyc:3.4.14.11-RXN +is_obsolete: true +replaced_by: GO:0008239 + +[Term] +id: GO:0017089 +name: glycolipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells." [GOC:ai] +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0017090 +name: meprin A complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] +synonym: "PABA peptide hydrolase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016021 ! integral to membrane + +[Term] +id: GO:0017091 +name: AU-rich element binding +namespace: molecular_function +def: "Interacting selectively with AU-rich elements within the 3' untranslated region of mRNAs." [GOC:mah, PMID:7892223] +synonym: "ARE binding" EXACT [] +synonym: "AU-specific RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0017092 +name: sterol regulatory element-binding protein site 2 protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525] +comment: This term was made obsolete because it represents a gene product. +synonym: "SREBP site 2 protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008237 + +[Term] +id: GO:0017093 +name: sterol regulatory element-binding protein protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] +comment: This term was made obsolete because it represents a gene product. +synonym: "SREBP protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0070011 + +[Term] +id: GO:0017094 +name: sterol regulatory element-binding protein site 1 protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525] +comment: This term was made obsolete because it represents a gene product. +synonym: "SREBP site 1 protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008236 + +[Term] +id: GO:0017095 +name: heparan sulfate 6-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] +synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] +synonym: "heparin 6-O-sulfotransferase activity" RELATED [] +xref: EC:2.8.2.- +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0017096 +name: acetylserotonin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin (N-acetyl-5-methoxytryptamine)." [EC:2.1.1.4] +subset: gosubset_prok +synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4] +synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4] +synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4] +synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] +synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] +xref: EC:2.1.1.4 +xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0017097 +name: acetylserotonin N-methyltransferase activity +namespace: molecular_function +is_a: GO:0008170 ! N-methyltransferase activity + +[Term] +id: GO:0017098 +name: sulfonylurea receptor binding +namespace: molecular_function +def: "Interacting selectively with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023] +synonym: "sulfonylurea receptor ligand" NARROW [] +synonym: "sulphonylurea receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0017099 +name: very-long-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +xref: EC:1.3.99.- +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0017100 +name: aminoacyl-tRNA synthetase auxiliary protein activity +namespace: molecular_function +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0017101 +name: aminoacyl-tRNA synthetase multienzyme complex +namespace: cellular_component +def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847] +synonym: "aminoacyl-tRNA synthetase complex" EXACT [] +synonym: "multisynthetase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0017102 +name: methionyl glutamyl tRNA synthetase complex +namespace: cellular_component +def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0017103 +name: UTP:galactose-1-phosphate uridylyltransferase activity +namespace: molecular_function +alt_id: GO:0003982 +def: "Catalysis of the reaction: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose." [EC:2.7.7.10] +synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] +synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10] +synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10] +synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] +synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10] +synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] +synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] +synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] +synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] +synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] +synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD [] +xref: EC:2.7.7.10 +xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0017105 +name: acyl-CoA delta11-desaturase activity +namespace: molecular_function +synonym: "acyl-CoA D11-desaturase activity" EXACT [] +synonym: "acyl-CoA delta(11)-desaturase activity" EXACT [] +is_a: GO:0016215 ! CoA desaturase activity + +[Term] +id: GO:0017106 +name: activin inhibitor activity +namespace: molecular_function +def: "Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0004871 ! signal transducer activity + +[Term] +id: GO:0017107 +name: anion exchanger adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +is_a: GO:0015380 ! anion exchanger activity +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0017108 +name: 5'-flap endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254, UniProtKB:P39749] +synonym: "5' flap endonuclease activity" EXACT [] +xref: Reactome:25632 +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters +is_a: GO:0048256 ! flap endonuclease activity + +[Term] +id: GO:0017109 +name: glutamate-cysteine ligase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] +synonym: "gamma-glutamylcysteine synthetase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0017110 +name: nucleoside-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] +synonym: "apyrase activity" BROAD [] +synonym: "CDPase" NARROW [EC:3.6.1.6] +synonym: "IDPase" NARROW [EC:3.6.1.6] +synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] +synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] +synonym: "NDPase activity" EXACT [EC:3.6.1.6] +synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6] +synonym: "nucleoside diphosphatase activity" EXACT [] +synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6] +synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] +synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] +synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] +synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] +xref: EC:3.6.1.6 +xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0017111 +name: nucleoside-triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] +subset: gosubset_prok +synonym: "apyrase activity" BROAD [] +synonym: "NTPase activity" EXACT [EC:3.6.1.15] +synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] +synonym: "nucleoside triphosphatase activity" EXACT [] +synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] +synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] +synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] +synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] +xref: EC:3.6.1.15 +xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0017112 +name: Rab guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0017113 +name: dihydropyrimidine dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] +subset: gosubset_prok +synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2] +synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2] +synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2] +synonym: "DHPDH" RELATED [EC:1.3.1.2] +synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2] +synonym: "dihydropyrimidine dehydrogenase activity" EXACT [] +synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2] +synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2] +synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2] +synonym: "DPD" RELATED [EC:1.3.1.2] +synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2] +xref: EC:1.3.1.2 +xref: MetaCyc:1.3.1.2-RXN +xref: Reactome:25636 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0017114 +name: wide-spectrum protease inhibitor activity +namespace: molecular_function +synonym: "wide-spectrum proteinase inhibitor" EXACT [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0017116 +name: single-stranded DNA-dependent ATP-dependent DNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +is_a: GO:0004003 ! ATP-dependent DNA helicase activity +is_a: GO:0043142 ! single-stranded DNA-dependent ATPase activity + +[Term] +id: GO:0017117 +name: single-stranded DNA-dependent ATP-dependent DNA helicase complex +namespace: cellular_component +def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah] +is_a: GO:0033202 ! DNA helicase complex + +[Term] +id: GO:0017118 +name: lipoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005] +subset: gosubset_prok +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0017119 +name: Golgi transport complex +namespace: cellular_component +def: "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665] +synonym: "COG complex" EXACT [] +synonym: "conserved oligomeric Golgi complex" EXACT [] +synonym: "Sec34/35 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044431 ! Golgi apparatus part + +[Term] +id: GO:0017120 +name: polyphosphoinositide phosphatase activity +namespace: molecular_function +def: "Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0017121 +name: phospholipid scrambling +namespace: biological_process +def: "The process by which all major lipid classes are redistributed within the plasma membrane following cell activation or injury, resulting in surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). Cell surface-exposed PS can serve as receptor sites for coagulation enzyme complexes, and contributes to cell clearance by the reticuloendothelial system." [PMID:11487015] +synonym: "PL scrambling" EXACT [] +is_a: GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0017122 +name: UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase complex +namespace: cellular_component +def: "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [UniProtKB:O15294] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0017123 +name: Ral GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Ral family." [GOC:mah] +is_a: GO:0005099 ! Ras GTPase activator activity + +[Term] +id: GO:0017124 +name: SH3 domain binding +namespace: molecular_function +def: "Interacting selectively with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0017125 +name: deoxycytidyl transferase activity +namespace: molecular_function +alt_id: GO:0019986 +def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901] +synonym: "deoxycytidyl transferase activity, template-dependent" NARROW [] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0017126 +name: nucleologenesis +namespace: biological_process +def: "The process by which the nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells, is formed and assembled." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "nucleolus biogenesis" EXACT [] +is_a: GO:0007000 ! nucleolus organization + +[Term] +id: GO:0017127 +name: cholesterol transporter activity +namespace: molecular_function +def: "Enables the directed movement of cholesterol into, out of, within or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] +is_a: GO:0015248 ! sterol transporter activity + +[Term] +id: GO:0017128 +name: phospholipid scramblase activity +namespace: molecular_function +is_a: GO:0005548 ! phospholipid transporter activity + +[Term] +id: GO:0017129 +name: triglyceride binding +namespace: molecular_function +def: "Interacting selectively with any triester of glycerol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0017130 +name: poly(rC) binding +namespace: molecular_function +def: "Interacting selectively with a sequence of cytosine residues in an RNA molecule." [GOC:mah] +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0017131 +name: uridine-rich cytoplasmic polyadenylylation element binding +namespace: molecular_function +def: "Interacting selectively with U-rich sequence in the 3'-end of mRNAs; required for cytoplasmic polyadenylylation." [PMID:7954828] +synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT [] +is_a: GO:0008187 ! poly-pyrimidine tract binding + +[Term] +id: GO:0017132 +name: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase; dependent on the presence of a cyclic nucleotide." [GOC:mah, PMID:9856955] +is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0017133 +name: mitochondrial electron transfer flavoprotein complex +namespace: cellular_component +def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "electron transfer flavoprotein complex (sensu Eukaryota)" EXACT [] +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0045251 ! electron transfer flavoprotein complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0017134 +name: fibroblast growth factor binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor." [PMID:9806903] +synonym: "FGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0017135 +name: membrane-associated protein with guanylate kinase activity interacting +namespace: molecular_function +def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005] +comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense. +is_obsolete: true +consider: GO:0019899 + +[Term] +id: GO:0017136 +name: NAD-dependent histone deacetylase activity +namespace: molecular_function +def: "Catalysis of the removal of one or more acetyl groups from a histone, requiring NAD." [GOC:ai, GOC:mah] +synonym: "SIR2" RELATED [] +is_a: GO:0004407 ! histone deacetylase activity +is_a: GO:0034979 ! NAD-dependent protein deacetylase activity + +[Term] +id: GO:0017137 +name: Rab GTPase binding +namespace: molecular_function +alt_id: GO:0005084 +def: "Interacting selectively with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] +synonym: "Rab escort protein activity" NARROW [] +synonym: "Rab interactor activity" RELATED [] +synonym: "REP" NARROW [] +is_a: GO:0005083 ! small GTPase regulator activity +is_a: GO:0017016 ! Ras GTPase binding + +[Term] +id: GO:0017139 +name: arsenate sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046685 + +[Term] +id: GO:0017140 +name: lipoic acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoic acid + 2 S = lipoic acid + 2 H." [PMID:11106496, PMID:11389890] +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0017141 +name: antibiotic susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046677 + +[Term] +id: GO:0017142 +name: toxin susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0009636 + +[Term] +id: GO:0017143 +name: insecticide metabolic process +namespace: biological_process +alt_id: GO:0017138 +def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] +subset: gosubset_prok +synonym: "insecticide metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0009404 ! toxin metabolic process +relationship: part_of GO:0017085 ! response to insecticide + +[Term] +id: GO:0017144 +name: drug metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2] +subset: goslim_pir +subset: gosubset_prok +synonym: "drug metabolism" EXACT [] +xref: Reactome:203852 +xref: Reactome:212852 +xref: Reactome:76397 +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0017145 +name: stem cell division +namespace: biological_process +def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jic, ISBN:0582227089] +synonym: "stem cell renewal" EXACT [] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0017146 +name: N-methyl-D-aspartate selective glutamate receptor complex +namespace: cellular_component +def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] +synonym: "NMDA-selective glutamate receptor" EXACT [] +is_a: GO:0008328 ! ionotropic glutamate receptor complex + +[Term] +id: GO:0017147 +name: Wnt-protein binding +namespace: molecular_function +def: "Interacting selectively with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0017148 +name: negative regulation of translation +namespace: biological_process +alt_id: GO:0016478 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] +subset: gosubset_prok +synonym: "down regulation of protein biosynthetic process" EXACT [] +synonym: "down-regulation of protein biosynthetic process" EXACT [] +synonym: "downregulation of protein biosynthetic process" EXACT [] +synonym: "inhibition of protein biosynthetic process" NARROW [] +synonym: "negative regulation of protein anabolism" EXACT [] +synonym: "negative regulation of protein biosynthesis" EXACT [] +synonym: "negative regulation of protein biosynthetic process" EXACT [] +synonym: "negative regulation of protein formation" EXACT [] +synonym: "negative regulation of protein synthesis" EXACT [] +synonym: "protein biosynthesis inhibitor activity" RELATED [] +synonym: "protein biosynthetic process inhibitor activity" RELATED [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +relationship: negatively_regulates GO:0006412 ! translation + +[Term] +id: GO:0017149 +name: protein biosynthetic process inhibitor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents involvement in a biological process. +synonym: "protein anabolism inhibitor activity" EXACT [] +synonym: "protein formation inhibitor activity" EXACT [] +synonym: "protein synthesis inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0017148 + +[Term] +id: GO:0017150 +name: tRNA dihydrouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] +subset: gosubset_prok +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0017151 +name: DEAD/H-box RNA helicase binding +namespace: molecular_function +def: "Interacting selectively with the enzyme DEAD/H-box RNA helicase." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0017153 +name: sodium:dicarboxylate symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] +subset: gosubset_prok +synonym: "sodium:dicarboxylate cotransporter activity" EXACT [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0017154 +name: semaphorin receptor activity +namespace: molecular_function +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0017155 +name: sodium:hydrogen antiporter regulator activity +namespace: molecular_function +alt_id: GO:0030040 +def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it represents a biological process. +synonym: "sodium:proton antiporter regulator" EXACT [] +is_obsolete: true + +[Term] +id: GO:0017156 +name: calcium ion-dependent exocytosis +namespace: biological_process +def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions." [GOC:go_curators] +is_a: GO:0006887 ! exocytosis + +[Term] +id: GO:0017157 +name: regulation of exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0006887 ! exocytosis + +[Term] +id: GO:0017158 +name: regulation of calcium ion-dependent exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] +is_a: GO:0017157 ! regulation of exocytosis +relationship: regulates GO:0017156 ! calcium ion-dependent exocytosis + +[Term] +id: GO:0017159 +name: pantetheine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol." [EC:3.5.1.92] +synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92] +synonym: "pantetheinase activity" EXACT [EC:3.5.1.92] +synonym: "vanin" RELATED [EC:3.5.1.92] +synonym: "vanin-1" RELATED [EC:3.5.1.92] +xref: EC:3.5.1.92 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0017160 +name: Ral GTPase binding +namespace: molecular_function +def: "Interacting selectively with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] +synonym: "Ral interactor activity" RELATED [] +is_a: GO:0017016 ! Ras GTPase binding + +[Term] +id: GO:0017161 +name: inositol-1,3,4-trisphosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] +xref: EC:3.1.3.- +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:0017162 +name: aryl hydrocarbon receptor binding +namespace: molecular_function +def: "Interacting selectively with an aryl hydrocarbon receptor." [GOC:ai] +is_a: GO:0005102 ! receptor binding +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0017163 +name: negative regulator of basal transcription activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0017164 +name: nicotinic acetylcholine receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0017165 +name: dipeptidase E activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "alpha-aspartyl dipeptidase activity" EXACT [] +synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21] +synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] +synonym: "peptidase E activity" BROAD [EC:3.4.13.21] +xref: EC:3.4.13.21 +xref: MetaCyc:3.4.13.21-RXN +is_obsolete: true +replaced_by: GO:0016805 + +[Term] +id: GO:0017166 +name: vinculin binding +namespace: molecular_function +def: "Interacting selectively with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0017168 +name: 5-oxoprolinase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate." [EC:3.5.2.9] +subset: gosubset_prok +synonym: "5-OPase activity" EXACT [EC:3.5.2.9] +synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9] +synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] +synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] +synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9] +synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] +synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9] +synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] +synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9] +synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9] +synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] +synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9] +xref: EC:3.5.2.9 +xref: MetaCyc:5-OXOPROLINASE-(ATP-HYDROLYSING)-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0017169 +name: CDP-alcohol phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] +subset: gosubset_prok +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0017170 +name: KU70 binding +namespace: molecular_function +def: "Interacting selectively with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0017171 +name: serine hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://en.wikipedia.org/wiki/Serine_hydrolase] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0017172 +name: cysteine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + O2 = 3-sulfinoalanine." [EC:1.13.11.20] +subset: gosubset_prok +xref: EC:1.13.11.20 +xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0017173 +name: DRAP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate." [GOC:jl, MetaCyc:YOL066C-MONOMER] +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0017174 +name: glycine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20] +synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20] +synonym: "GNMT" RELATED [EC:2.1.1.20] +synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20] +synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20] +xref: EC:2.1.1.20 +xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0017175 +name: IMP-GMP specific 5'-nucleotidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc] +comment: This term was made obsolete because it represents a gene product with two different activities. +is_obsolete: true +consider: GO:0050484 + +[Term] +id: GO:0017176 +name: phosphatidylinositol N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] +synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198] +synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] +synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] +synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] +xref: EC:2.4.1.198 +xref: MetaCyc:2.4.1.198-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0017177 +name: alpha-glucosidase II complex +namespace: cellular_component +def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] +comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0017178 +name: diphthine-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + diphthine + NH3 = ADP + phosphate + diphthamide." [EC:6.3.2.22] +synonym: "diphthamide synthase activity" EXACT [EC:6.3.2.22] +synonym: "diphthamide synthetase activity" EXACT [EC:6.3.2.22] +synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.2.22] +xref: EC:6.3.2.22 +xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN +is_a: GO:0016211 ! ammonia ligase activity + +[Term] +id: GO:0017179 +name: peptidyl-diphthine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] +subset: gosubset_prok +synonym: "peptidyl-diphthine metabolism" EXACT [] +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0017180 +name: peptidyl-diphthine biosynthetic process from peptidyl-histidine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators] +subset: gosubset_prok +synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0017179 ! peptidyl-diphthine metabolic process + +[Term] +id: GO:0017181 +name: peptidyl-diphthine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] +subset: gosubset_prok +synonym: "peptidyl-diphthine breakdown" EXACT [] +synonym: "peptidyl-diphthine catabolism" EXACT [] +synonym: "peptidyl-diphthine degradation" EXACT [] +is_a: GO:0017179 ! peptidyl-diphthine metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0017182 +name: peptidyl-diphthamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] +subset: gosubset_prok +synonym: "peptidyl-diphthamide metabolism" EXACT [] +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0017183 +name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine +namespace: biological_process +def: "The posttranslational modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2." [RESID:AA0040] +subset: gosubset_prok +synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT [] +xref: RESID:AA0040 +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0017182 ! peptidyl-diphthamide metabolic process + +[Term] +id: GO:0017184 +name: peptidyl-diphthamide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] +subset: gosubset_prok +synonym: "peptidyl-diphthamide breakdown" EXACT [] +synonym: "peptidyl-diphthamide catabolism" EXACT [] +synonym: "peptidyl-diphthamide degradation" EXACT [] +is_a: GO:0017182 ! peptidyl-diphthamide metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0017185 +name: peptidyl-lysine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018126 ! protein amino acid hydroxylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0017186 +name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] +comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'. +subset: gosubset_prok +synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT [] +synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT [] +synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT [] +synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT [] +synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT [] +xref: RESID:AA0031 +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0017187 +name: peptidyl-glutamic acid carboxylation +namespace: biological_process +def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032] +comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'. +subset: gosubset_prok +xref: Reactome:159740 +xref: Reactome:159854 +xref: Reactome:211902 +xref: Reactome:212085 +xref: Reactome:221666 +xref: Reactome:221843 +xref: Reactome:230411 +xref: Reactome:238293 +xref: Reactome:238452 +xref: RESID:AA0032 +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018214 ! protein amino acid carboxylation + +[Term] +id: GO:0017188 +name: aspartate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-aspartate = CoA + N-acetyl-L-aspartate." [EC:2.3.1.17] +synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] +synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17] +synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] +xref: EC:2.3.1.17 +xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0017189 +name: N-terminal peptidyl-alanine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041] +comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'. +subset: gosubset_prok +xref: RESID:AA0041 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0017190 +name: N-terminal peptidyl-aspartic acid acetylation +namespace: biological_process +def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042] +comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. +subset: gosubset_prok +xref: RESID:AA0042 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0017192 +name: N-terminal peptidyl-glutamine acetylation +namespace: biological_process +def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045] +subset: gosubset_prok +xref: RESID:AA0045 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0017193 +name: N-terminal peptidyl-glycine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046] +subset: gosubset_prok +xref: RESID:AA0046 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0017194 +name: N-terminal peptidyl-isoleucine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047] +subset: gosubset_prok +xref: RESID:AA0047 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018203 ! peptidyl-isoleucine modification + +[Term] +id: GO:0017195 +name: N-terminal peptidyl-lysine N2-acetylation +namespace: biological_process +def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine." [RESID:AA0048] +subset: gosubset_prok +xref: RESID:AA0048 +is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation + +[Term] +id: GO:0017196 +name: N-terminal peptidyl-methionine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049] +subset: gosubset_prok +xref: RESID:AA0049 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0017197 +name: N-terminal peptidyl-proline acetylation +namespace: biological_process +def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050] +subset: gosubset_prok +xref: RESID:AA0050 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0017198 +name: N-terminal peptidyl-serine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051] +subset: gosubset_prok +xref: RESID:AA0051 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030920 ! peptidyl-serine acetylation + +[Term] +id: GO:0017199 +name: N-terminal peptidyl-threonine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052] +comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'. +subset: gosubset_prok +xref: RESID:AA0052 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018000 +name: N-terminal peptidyl-tyrosine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053] +subset: gosubset_prok +xref: RESID:AA0053 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018001 +name: N-terminal peptidyl-valine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054] +subset: gosubset_prok +xref: RESID:AA0054 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018213 ! peptidyl-valine modification + +[Term] +id: GO:0018002 +name: N-terminal peptidyl-glutamic acid acetylation +namespace: biological_process +def: "The acetylation of the N-terminal glutamic acid of proteins; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0044] +comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. +subset: gosubset_prok +xref: RESID:AA0044 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018003 +name: peptidyl-lysine N6-acetylation +namespace: biological_process +def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine; catalyzed by tubulin N-acetyltransferase." [RESID:AA0055] +comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'. +subset: gosubset_prok +xref: RESID:AA0055 +is_a: GO:0018393 ! internal peptidyl-lysine acetylation + +[Term] +id: GO:0018004 +name: N-terminal protein formylation +namespace: biological_process +def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018256 ! protein amino acid formylation +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0018005 +name: N-terminal peptidyl-glycine N-formylation +namespace: biological_process +def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057] +subset: gosubset_prok +xref: RESID:AA0057 +is_a: GO:0018004 ! N-terminal protein formylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018006 +name: N-terminal protein amino acid glucuronylation +namespace: biological_process +def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018321 ! protein amino acid glucuronylation +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0018007 +name: N-terminal peptidyl-glycine N-glucuronylation +namespace: biological_process +def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058] +subset: gosubset_prok +xref: RESID:AA0058 +is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018008 +name: N-terminal peptidyl-glycine N-myristoylation +namespace: biological_process +def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059] +subset: gosubset_prok +synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT [] +xref: RESID:AA0059 +is_a: GO:0006499 ! N-terminal protein myristoylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018009 +name: N-terminal peptidyl-L-cysteine N-palmitoylation +namespace: biological_process +def: "The palmitoylation of the N-terminal cysteine of proteins to form the derivative N-palmitoyl-cysteine." [RESID:AA0060] +subset: gosubset_prok +xref: RESID:AA0060 +is_a: GO:0006500 ! N-terminal protein palmitoylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018010 +name: glycoprotein N-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96] +synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96] +synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96] +xref: EC:2.3.1.96 +xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN +is_a: GO:0019105 ! N-palmitoyltransferase activity + +[Term] +id: GO:0018011 +name: N-terminal peptidyl-alanine methylation +namespace: biological_process +def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062] +subset: gosubset_prok +xref: RESID:AA0061 +xref: RESID:AA0062 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0018012 +name: N-terminal peptidyl-alanine trimethylation +namespace: biological_process +def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062] +subset: gosubset_prok +xref: RESID:AA0062 +is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation + +[Term] +id: GO:0018013 +name: N-terminal peptidyl-glycine methylation +namespace: biological_process +def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063] +subset: gosubset_prok +xref: RESID:AA0063 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018014 +name: N-terminal peptidyl-methionine methylation +namespace: biological_process +def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064] +subset: gosubset_prok +xref: RESID:AA0064 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018015 +name: N-terminal peptidyl-phenylalanine methylation +namespace: biological_process +def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065] +subset: gosubset_prok +xref: RESID:AA0065 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018016 +name: N-terminal peptidyl-proline dimethylation +namespace: biological_process +def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066] +subset: gosubset_prok +xref: RESID:AA0066 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0018019 +name: N-terminal peptidyl-glutamine methylation +namespace: biological_process +def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071] +subset: gosubset_prok +xref: RESID:AA0071 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0018020 +name: peptidyl-glutamic acid methylation +namespace: biological_process +def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006479 ! protein amino acid methylation + +[Term] +id: GO:0018021 +name: peptidyl-histidine methylation +namespace: biological_process +def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317] +subset: gosubset_prok +xref: RESID:AA0073 +xref: RESID:AA0317 +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018022 +name: peptidyl-lysine methylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018023 +name: peptidyl-lysine trimethylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074] +subset: gosubset_prok +xref: RESID:AA0074 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0018024 +name: histone-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] +synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43] +synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43] +synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43] +synonym: "protein methylase III activity" NARROW [EC:2.1.1.43] +synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43] +synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43] +synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43] +xref: EC:2.1.1.43 +xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN +xref: RESID:AA0074 +xref: RESID:AA0075 +xref: RESID:AA0076 +is_a: GO:0016279 ! protein-lysine N-methyltransferase activity +is_a: GO:0042054 ! histone methyltransferase activity + +[Term] +id: GO:0018025 +name: calmodulin-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60] +synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60] +synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60] +synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60] +xref: EC:2.1.1.60 +xref: MetaCyc:2.1.1.60-RXN +is_a: GO:0016279 ! protein-lysine N-methyltransferase activity + +[Term] +id: GO:0018026 +name: peptidyl-lysine monomethylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076] +subset: gosubset_prok +xref: RESID:AA0076 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0018027 +name: peptidyl-lysine dimethylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075] +subset: gosubset_prok +xref: RESID:AA0075 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0018028 +name: peptidyl-lysine myristoylation +namespace: biological_process +def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078] +subset: gosubset_prok +synonym: "peptidyl-lysine myristylation" EXACT [] +xref: RESID:AA0078 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018319 ! protein amino acid myristoylation + +[Term] +id: GO:0018029 +name: peptidyl-lysine palmitoylation +namespace: biological_process +def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077] +subset: gosubset_prok +xref: RESID:AA0077 +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018030 +name: peptidyl-lysine N6-myristoyltransferase activity +namespace: molecular_function +xref: EC:2.3.1.- +is_a: GO:0004379 ! glycylpeptide N-tetradecanoyltransferase activity + +[Term] +id: GO:0018031 +name: peptidyl-lysine N6-palmitoyltransferase activity +namespace: molecular_function +xref: EC:2.3.1.- +is_a: GO:0019105 ! N-palmitoyltransferase activity + +[Term] +id: GO:0018032 +name: protein amino acid amidation +namespace: biological_process +def: "Addition of an amide group from a glycine to a protein amino acid." [SP_KW:KW-0027] +subset: gosubset_prok +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0018033 +name: protein C-terminal amidation +namespace: biological_process +def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018032 ! protein amino acid amidation +is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking + +[Term] +id: GO:0018034 +name: C-terminal peptidyl-alanine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081] +subset: gosubset_prok +xref: RESID:AA0081 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0018035 +name: C-terminal peptidyl-arginine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082] +subset: gosubset_prok +xref: RESID:AA0082 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018036 +name: C-terminal peptidyl-asparagine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083] +subset: gosubset_prok +xref: RESID:AA0083 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018037 +name: C-terminal peptidyl-aspartic acid amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084] +subset: gosubset_prok +xref: RESID:AA0084 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0018038 +name: C-terminal peptidyl-cysteine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085] +subset: gosubset_prok +xref: RESID:AA0085 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018039 +name: C-terminal peptidyl-glutamine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086] +subset: gosubset_prok +xref: RESID:AA0086 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0018040 +name: C-terminal peptidyl-glutamic acid amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087] +subset: gosubset_prok +xref: RESID:AA0087 +is_a: GO:0018033 ! protein C-terminal amidation + +[Term] +id: GO:0018041 +name: C-terminal peptidyl-glycine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088] +subset: gosubset_prok +xref: RESID:AA0088 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018042 +name: C-terminal peptidyl-histidine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089] +subset: gosubset_prok +xref: RESID:AA0089 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018043 +name: C-terminal peptidyl-isoleucine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090] +subset: gosubset_prok +xref: RESID:AA0090 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018203 ! peptidyl-isoleucine modification + +[Term] +id: GO:0018044 +name: C-terminal peptidyl-leucine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091] +subset: gosubset_prok +xref: RESID:AA0091 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018204 ! peptidyl-leucine modification + +[Term] +id: GO:0018045 +name: C-terminal peptidyl-lysine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092] +subset: gosubset_prok +xref: RESID:AA0092 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018046 +name: C-terminal peptidyl-methionine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093] +subset: gosubset_prok +xref: RESID:AA0093 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018047 +name: C-terminal peptidyl-phenylalanine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094] +subset: gosubset_prok +xref: RESID:AA0094 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018048 +name: C-terminal peptidyl-proline amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095] +subset: gosubset_prok +xref: RESID:AA0095 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0018049 +name: C-terminal peptidyl-serine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096] +subset: gosubset_prok +xref: RESID:AA0096 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018050 +name: C-terminal peptidyl-threonine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097] +subset: gosubset_prok +xref: RESID:AA0097 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018051 +name: C-terminal peptidyl-tryptophan amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098] +subset: gosubset_prok +xref: RESID:AA0098 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018052 +name: C-terminal peptidyl-tyrosine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099] +subset: gosubset_prok +xref: RESID:AA0099 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018053 +name: C-terminal peptidyl-valine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100] +subset: gosubset_prok +xref: RESID:AA0100 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018213 ! peptidyl-valine modification + +[Term] +id: GO:0018054 +name: peptidyl-lysine biotinylation +namespace: biological_process +def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] +subset: gosubset_prok +xref: RESID:AA0117 +is_a: GO:0009305 ! protein amino acid biotinylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018055 +name: peptidyl-lysine lipoylation +namespace: biological_process +def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118] +subset: gosubset_prok +xref: RESID:AA0118 +is_a: GO:0009249 ! protein lipoylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018057 +name: peptidyl-lysine oxidation +namespace: biological_process +def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121] +subset: gosubset_prok +xref: RESID:AA0121 +is_a: GO:0018158 ! protein amino acid oxidation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018058 +name: N-terminal protein amino acid deamination, from amino carbon +namespace: biological_process +def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129] +subset: gosubset_prok +xref: RESID:AA0127 +xref: RESID:AA0128 +xref: RESID:AA0129 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018277 ! protein amino acid deamination +is_a: GO:0018409 ! peptide or protein amino-terminal blocking +is_a: GO:0031363 ! N-terminal protein amino acid deamination + +[Term] +id: GO:0018059 +name: N-terminal peptidyl-serine deamination +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018060 +name: N-terminal peptidyl-cysteine deamination +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018061 +name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine +namespace: biological_process +def: "The posttranslational modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128] +subset: gosubset_prok +synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT [] +synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT [] +synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT [] +xref: RESID:AA0128 +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018062 +name: peptidyl-tryptophan succinylation +namespace: biological_process +def: "The posttranslational modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130] +subset: gosubset_prok +xref: RESID:AA0130 +is_a: GO:0018211 ! peptidyl-tryptophan modification +is_a: GO:0018335 ! protein amino acid succinylation + +[Term] +id: GO:0018063 +name: cytochrome c-heme linkage +namespace: biological_process +def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135] +subset: gosubset_prok +synonym: "cytochrome c-haem linkage" EXACT [] +xref: RESID:AA0134 +xref: RESID:AA0135 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0018064 +name: protein-histidine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85] +synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85] +synonym: "peptidyl-histidine N-methyltransferase activity" EXACT [] +synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85] +synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85] +synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85] +synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85] +xref: EC:2.1.1.85 +xref: MetaCyc:2.1.1.85-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0018065 +name: protein-cofactor linkage +namespace: biological_process +def: "The covalent linking of a cofactor to a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018067 +name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The posttranslational modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146] +subset: gosubset_prok +synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] +xref: RESID:AA0146 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation + +[Term] +id: GO:0018068 +name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The posttranslational modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147] +subset: gosubset_prok +synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT [] +xref: RESID:AA0147 +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018069 +name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone +namespace: biological_process +def: "The posttranslational cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149] +subset: gosubset_prok +xref: RESID:AA0149 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018070 +name: peptidyl-serine phosphopantetheinylation +namespace: biological_process +def: "The posttranslational phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150] +subset: gosubset_prok +xref: RESID:AA0150 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018215 ! protein amino acid phosphopantetheinylation + +[Term] +id: GO:0018071 +name: NAD(P)-cysteine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-] +xref: EC:2.4.2.- +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0018072 +name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid +namespace: biological_process +def: "The posttranslational modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170] +subset: gosubset_prok +synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT [] +xref: RESID:AA0170 +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018073 +name: protein amino acid bromination +namespace: biological_process +def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018079 ! protein amino acid halogenation + +[Term] +id: GO:0018074 +name: peptidyl-histidine bromination +namespace: biological_process +def: "The posttranslational bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173] +subset: gosubset_prok +xref: RESID:AA0173 +is_a: GO:0018073 ! protein amino acid bromination +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018075 +name: peptidyl-phenylalanine bromination +namespace: biological_process +def: "The posttranslational bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176] +subset: gosubset_prok +xref: RESID:AA0174 +xref: RESID:AA0175 +xref: RESID:AA0176 +is_a: GO:0018073 ! protein amino acid bromination +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018076 +name: N-terminal peptidyl-lysine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:0018077 +name: protein amino acid iodination +namespace: biological_process +def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018079 ! protein amino acid halogenation + +[Term] +id: GO:0018078 +name: peptidyl-thyronine iodination +namespace: biological_process +def: "The posttranslational iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178] +subset: gosubset_prok +xref: RESID:AA0177 +xref: RESID:AA0178 +is_a: GO:0018077 ! protein amino acid iodination +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018079 +name: protein amino acid halogenation +namespace: biological_process +def: "The addition of a halogen to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018080 +name: peptidyl-tryptophan bromination +namespace: biological_process +def: "The posttranslational bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179] +subset: gosubset_prok +xref: RESID:AA0179 +is_a: GO:0018073 ! protein amino acid bromination +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018081 +name: peptide cross-linking via lanthionine or 3-methyl-lanthionine +namespace: biological_process +def: "The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112] +subset: gosubset_prok +synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT [] +synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT [] +xref: RESID:AA0110 +xref: RESID:AA0111 +xref: RESID:AA0112 +is_a: GO:0018149 ! peptide cross-linking + +[Term] +id: GO:0018082 +name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine +namespace: biological_process +def: "The formation of (Z)-dehydrobutyrine by the posttranslational dehydration of peptidyl-threonine." [RESID:AA0182] +subset: gosubset_prok +synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT [] +synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT [] +synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT [] +xref: RESID:AA0182 +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018083 +name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185] +subset: gosubset_prok +synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT [] +synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT [] +synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT [] +xref: RESID:AA0185 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018084 +name: peptidyl-lactic acid biosynthetic process from peptidyl-serine +namespace: biological_process +def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186] +subset: gosubset_prok +synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT [] +synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT [] +synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT [] +xref: RESID:AA0186 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018085 +name: peptidyl-L-amino acid racemization +namespace: biological_process +def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification +is_a: GO:0018366 ! L-amino acid racemization + +[Term] +id: GO:0018086 +name: alanine racemization +namespace: biological_process +alt_id: GO:0018368 +def: "OBSOLETE (was not defined before being made obsolete)." [RESID:AA0191] +comment: This term was made obsolete because it was replaced with more appropriate terms. +is_obsolete: true +consider: GO:0019122 + +[Term] +id: GO:0018091 +name: peptidyl-asparagine racemization +namespace: biological_process +alt_id: GO:0018373 +alt_id: GO:0019127 +def: "The racemization of peptidyl-asparagine." [RESID:AA0196] +subset: gosubset_prok +xref: RESID:AA0196 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018094 +name: protein polyglycylation +namespace: biological_process +def: "The posttranslational addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201] +subset: gosubset_prok +xref: RESID:AA0201 +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018095 +name: protein polyglutamylation +namespace: biological_process +def: "The posttranslational addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202] +subset: gosubset_prok +xref: RESID:AA0202 +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018096 +name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine +namespace: biological_process +def: "The posttranslational synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204] +subset: gosubset_prok +xref: RESID:AA0204 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018097 +name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine +namespace: biological_process +def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207] +subset: gosubset_prok +synonym: "protein amino acid cinnamylation" BROAD [] +xref: RESID:AA0207 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0018101 +name: peptidyl-citrulline biosynthetic process from peptidyl-arginine +namespace: biological_process +def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [RESID:AA0214] +subset: gosubset_prok +synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT [] +synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT [] +synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT [] +xref: RESID:AA0214 +is_a: GO:0018195 ! peptidyl-arginine modification +is_a: GO:0019240 ! citrulline biosynthetic process + +[Term] +id: GO:0018102 +name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine +namespace: biological_process +def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215] +subset: gosubset_prok +xref: RESID:AA0215 +is_a: GO:0018126 ! protein amino acid hydroxylation +is_a: GO:0030961 ! peptidyl-arginine hydroxylation + +[Term] +id: GO:0018103 +name: protein amino acid C-linked glycosylation +namespace: biological_process +def: "The glycosylation of a peptidyl-amino acid residue at a C atom." [PMID:7947762, RESID:AA0217] +subset: gosubset_prok +xref: RESID:AA0217 +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0018104 +name: peptidoglycan-protein cross-linking +namespace: biological_process +def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0009252 ! peptidoglycan biosynthetic process + +[Term] +id: GO:0018105 +name: peptidyl-serine phosphorylation +namespace: biological_process +def: "The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] +subset: gosubset_prok +xref: RESID:AA0037 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018106 +name: peptidyl-histidine phosphorylation +namespace: biological_process +def: "The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036] +subset: gosubset_prok +xref: RESID:AA0035 +xref: RESID:AA0036 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018107 +name: peptidyl-threonine phosphorylation +namespace: biological_process +def: "The posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] +subset: gosubset_prok +xref: RESID:AA0038 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018108 +name: peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "The posttranslational phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] +subset: gosubset_prok +xref: RESID:AA0039 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018109 +name: peptidyl-arginine phosphorylation +namespace: biological_process +def: "The posttranslational phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222] +subset: gosubset_prok +xref: RESID:AA0222 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018110 +name: histone arginine kinase activity +namespace: molecular_function +synonym: "histone-arginine kinase activity" EXACT [] +xref: EC:2.7.3.- +is_a: GO:0004054 ! arginine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0018111 +name: methionine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2] +xref: EC:5.1.1.2 +xref: MetaCyc:METHIONINE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0018112 +name: proline racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4] +subset: gosubset_prok +xref: EC:5.1.1.4 +xref: MetaCyc:PROLINE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0018113 +name: lysine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5] +xref: EC:5.1.1.5 +xref: MetaCyc:LYSINE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0018114 +name: threonine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6] +xref: EC:5.1.1.6 +xref: MetaCyc:THREONINE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0018115 +name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The co- or posttranslational modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223] +subset: gosubset_prok +synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0223 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018116 +name: peptidyl-lysine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227] +subset: gosubset_prok +synonym: "peptidyl-lysine adenylation" EXACT [] +xref: RESID:AA0227 +is_a: GO:0018117 ! protein amino acid adenylylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018117 +name: protein amino acid adenylylation +namespace: biological_process +alt_id: GO:0018176 +def: "The addition of phospho-adenosine to a protein amino acid." [GOC:ai] +subset: gosubset_prok +synonym: "protein adenylation" EXACT [] +is_a: GO:0018175 ! protein amino acid nucleotidylation + +[Term] +id: GO:0018118 +name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229] +subset: gosubset_prok +synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT [] +xref: RESID:AA0229 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018119 +name: peptidyl-cysteine S-nitrosylation +namespace: biological_process +def: "The posttranslational S-nitrosylation of peptidyl-cysteine to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230] +subset: gosubset_prok +xref: RESID:AA0230 +is_a: GO:0017014 ! protein amino acid nitrosylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018120 +name: peptidyl-arginine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168] +subset: gosubset_prok +xref: RESID:AA0168 +is_a: GO:0006471 ! protein amino acid ADP-ribosylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018121 +name: NAD(P)-asparagine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-] +xref: EC:2.4.2.- +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0018122 +name: peptidyl-asparagine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231] +subset: gosubset_prok +xref: RESID:AA0231 +is_a: GO:0006471 ! protein amino acid ADP-ribosylation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018123 +name: peptidyl-cysteine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169] +subset: gosubset_prok +xref: RESID:AA0169 +is_a: GO:0006471 ! protein amino acid ADP-ribosylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018124 +name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone +namespace: biological_process +def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233] +subset: gosubset_prok +xref: RESID:AA0233 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018125 +name: peptidyl-cysteine methylation +namespace: biological_process +def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234] +subset: gosubset_prok +xref: RESID:AA0234 +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018126 +name: protein amino acid hydroxylation +namespace: biological_process +def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018127 +name: NAD(P)-serine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-] +xref: EC:2.4.2.- +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0018128 +name: peptidyl-serine cyclase activity +namespace: molecular_function +xref: EC:4.2.1.- +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018129 +name: peptidyl-oxazoline dehydrogenase activity +namespace: molecular_function +xref: EC:1.3.-.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018130 +name: heterocycle biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] +subset: gosubset_prok +synonym: "heterocycle anabolism" EXACT [] +synonym: "heterocycle biosynthesis" EXACT [] +synonym: "heterocycle formation" EXACT [] +synonym: "heterocycle synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018131 +name: oxazole or thiazole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "oxazole or thiazole anabolism" EXACT [] +synonym: "oxazole or thiazole biosynthesis" EXACT [] +synonym: "oxazole or thiazole formation" EXACT [] +synonym: "oxazole or thiazole synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046484 ! oxazole or thiazole metabolic process + +[Term] +id: GO:0018132 +name: peptide cross-linking via L-cysteine oxazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238] +subset: gosubset_prok +xref: RESID:AA0238 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018133 +name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239] +subset: gosubset_prok +xref: RESID:AA0239 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018134 +name: peptide cross-linking via glycine oxazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240] +subset: gosubset_prok +xref: RESID:AA0240 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018135 +name: peptidyl-cysteine cyclase activity +namespace: molecular_function +xref: EC:4.2.1.- +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018136 +name: peptidyl-thiazoline dehydrogenase activity +namespace: molecular_function +xref: EC:1.3.-.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018137 +name: peptide cross-linking via glycine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241] +subset: gosubset_prok +xref: RESID:AA0241 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018138 +name: peptide cross-linking via L-serine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242] +subset: gosubset_prok +xref: RESID:AA0242 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018139 +name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243] +subset: gosubset_prok +xref: RESID:AA0243 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018140 +name: peptide cross-linking via L-cysteine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244] +subset: gosubset_prok +xref: RESID:AA0244 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018141 +name: peptide cross-linking via L-lysine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245] +subset: gosubset_prok +xref: RESID:AA0245 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018142 +name: DNA-protein covalent cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma] +subset: gosubset_prok +is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking + +[Term] +id: GO:0018143 +name: nucleic acid-protein covalent cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018144 +name: RNA-protein covalent cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma] +subset: gosubset_prok +is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking + +[Term] +id: GO:0018145 +name: DNA-protein covalent cross-linking via peptidyl-serine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246] +subset: gosubset_prok +xref: RESID:AA0246 +is_a: GO:0018142 ! DNA-protein covalent cross-linking +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018146 +name: keratan sulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247] +subset: gosubset_prok +synonym: "keratan sulfate anabolism" EXACT [] +synonym: "keratan sulfate biosynthesis" EXACT [] +synonym: "keratan sulfate formation" EXACT [] +synonym: "keratan sulfate synthesis" EXACT [] +synonym: "keratan sulphate biosynthesis" EXACT [] +synonym: "keratan sulphate biosynthetic process" EXACT [] +xref: RESID:AA0247 +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0042339 ! keratan sulfate metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0018147 +name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248] +subset: gosubset_prok +xref: RESID:AA0248 +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex +is_a: GO:0050844 ! peptidyl-selenocysteine modification + +[Term] +id: GO:0018148 +name: RNA-protein covalent cross-linking via peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249] +subset: gosubset_prok +xref: RESID:AA0249 +is_a: GO:0018144 ! RNA-protein covalent cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018149 +name: peptide cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018150 +name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine +namespace: biological_process +def: "The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250] +subset: gosubset_prok +xref: RESID:AA0250 +is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine + +[Term] +id: GO:0018151 +name: peptide cross-linking via L-histidyl-L-tyrosine +namespace: biological_process +def: "The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018152 +name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine +namespace: biological_process +def: "The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270] +subset: gosubset_prok +xref: RESID:AA0270 +is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine + +[Term] +id: GO:0018153 +name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124] +subset: gosubset_prok +xref: RESID:AA0124 +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0018154 +name: peptide cross-linking via (2R,6R)-lanthionine +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110] +subset: gosubset_prok +xref: RESID:AA0110 +is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018155 +name: peptide cross-linking via sn-(2S,6R)-lanthionine +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111] +subset: gosubset_prok +xref: RESID:AA0111 +is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018156 +name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112] +subset: gosubset_prok +xref: RESID:AA0112 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018157 +name: peptide cross-linking via an oxazole or thiazole +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0018131 ! oxazole or thiazole biosynthetic process +is_a: GO:0018149 ! peptide cross-linking + +[Term] +id: GO:0018158 +name: protein amino acid oxidation +namespace: biological_process +def: "The modification of a protein amino acid by oxidation." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018159 +name: peptidyl-methionine oxidation +namespace: biological_process +def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251] +subset: gosubset_prok +xref: RESID:AA0251 +is_a: GO:0018158 ! protein amino acid oxidation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018160 +name: peptidyl-pyrromethane cofactor linkage +namespace: biological_process +def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [RESID:AA0252] +subset: gosubset_prok +xref: RESID:AA0252 +is_a: GO:0018065 ! protein-cofactor linkage + +[Term] +id: GO:0018161 +name: dipyrrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] +subset: gosubset_prok +synonym: "dipyrrin anabolism" EXACT [] +synonym: "dipyrrin biosynthesis" EXACT [] +synonym: "dipyrrin formation" EXACT [] +synonym: "dipyrrin synthesis" EXACT [] +synonym: "dipyrromethane biosynthesis" EXACT [] +synonym: "dipyrromethane biosynthetic process" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0046453 ! dipyrrin metabolic process + +[Term] +id: GO:0018162 +name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine +namespace: biological_process +def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253] +subset: gosubset_prok +xref: RESID:AA0253 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018163 +name: DNA-protein covalent cross-linking via the 5'-end to peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254] +subset: gosubset_prok +synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [] +xref: RESID:AA0254 +is_a: GO:0018142 ! DNA-protein covalent cross-linking +is_a: GO:0045327 ! DNA-protein covalent cross-linking via peptidyl-tyrosine + +[Term] +id: GO:0018164 +name: DNA-protein covalent cross-linking via peptidyl-threonine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255] +subset: gosubset_prok +xref: RESID:AA0255 +is_a: GO:0018142 ! DNA-protein covalent cross-linking +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018165 +name: peptidyl-tyrosine uridylylation +namespace: biological_process +def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256] +subset: gosubset_prok +xref: RESID:AA0256 +is_a: GO:0018177 ! protein amino acid uridylylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018166 +name: C-terminal protein-tyrosinylation +namespace: biological_process +def: "The ATP-dependent posttranslational addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257] +comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'. +subset: gosubset_prok +xref: RESID:AA0257 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018322 ! protein amino acid tyrosinylation +is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking + +[Term] +id: GO:0018167 +name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine +namespace: biological_process +def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259] +subset: gosubset_prok +xref: RESID:AA0259 +is_a: GO:0017011 ! protein-phycoerythrobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018168 +name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine +namespace: biological_process +def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132] +subset: gosubset_prok +xref: RESID:AA0132 +is_a: GO:0017011 ! protein-phycoerythrobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018169 +name: ribosomal S6-glutamic acid ligase activity +namespace: molecular_function +xref: EC:6.3.2.- +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0018170 +name: C-terminal peptidyl-polyglutamic acid amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261] +subset: gosubset_prok +xref: RESID:AA0261 +is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018171 +name: peptidyl-cysteine oxidation +namespace: biological_process +def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262] +subset: gosubset_prok +xref: RESID:AA0205 +xref: RESID:AA0262 +is_a: GO:0018158 ! protein amino acid oxidation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018172 +name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The, presumably, posttranslational modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263] +subset: gosubset_prok +synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] +xref: RESID:AA0263 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation + +[Term] +id: GO:0018173 +name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] +subset: gosubset_prok +synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT [] +synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT [] +synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT [] +xref: RESID:AA0265 +is_a: GO:0018201 ! peptidyl-glycine modification +relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process + +[Term] +id: GO:0018174 +name: protein-heme P460 linkage +namespace: biological_process +def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271] +subset: gosubset_prok +synonym: "protein-haem P460 linkage" EXACT [] +xref: RESID:AA0266 +xref: RESID:AA0271 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0018175 +name: protein amino acid nucleotidylation +namespace: biological_process +def: "The addition of a nucleotide to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018177 +name: protein amino acid uridylylation +namespace: biological_process +def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0018175 ! protein amino acid nucleotidylation + +[Term] +id: GO:0018178 +name: peptidyl-threonine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267] +subset: gosubset_prok +synonym: "peptidyl-threonine adenylation" EXACT [] +xref: RESID:AA0267 +is_a: GO:0018117 ! protein amino acid adenylylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018179 +name: peptidyl-cysteine desulfurization +namespace: biological_process +def: "The posttranslational desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269] +subset: gosubset_prok +synonym: "peptidyl-cysteine desulphurization" EXACT [] +xref: RESID:AA0269 +is_a: GO:0018180 ! protein amino acid desulfurization + +[Term] +id: GO:0018180 +name: protein amino acid desulfurization +namespace: biological_process +def: "The removal of a sulfur group from a protein amino acid." [GOC:ai] +subset: gosubset_prok +synonym: "protein amino acid desulfurisation" EXACT [] +synonym: "protein amino acid desulphurisation" EXACT [] +synonym: "protein amino acid desulphurization" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018181 +name: peptidyl-arginine C5-methylation +namespace: biological_process +def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272] +subset: gosubset_prok +synonym: "peptidyl-arginine 5-methylation" EXACT [] +xref: RESID:AA0272 +is_a: GO:0035245 ! peptidyl-arginine C-methylation + +[Term] +id: GO:0018182 +name: protein-heme linkage via 3'-L-histidine +namespace: biological_process +def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276] +subset: gosubset_prok +synonym: "protein-haem linkage via 3'-L-histidine" EXACT [] +xref: RESID:AA0276 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018183 +name: enzyme active site formation via S-selenyl-L-cysteine +namespace: biological_process +def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277] +comment: This term was made obsolete because this structure does not exist. +is_obsolete: true + +[Term] +id: GO:0018184 +name: protein amino acid polyamination +namespace: biological_process +def: "The modification of a protein amino acid by polyamination." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018185 +name: poly-N-methyl-propylamination +namespace: biological_process +def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278] +subset: gosubset_prok +xref: RESID:AA0278 +is_a: GO:0018184 ! protein amino acid polyamination +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018186 +name: peroxidase-heme linkage +namespace: biological_process +def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280] +subset: gosubset_prok +synonym: "peroxidase-haem linkage" EXACT [] +xref: RESID:AA0279 +xref: RESID:AA0280 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0018187 +name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide +namespace: biological_process +def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281] +subset: gosubset_prok +xref: RESID:AA0281 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0018188 +name: peptidyl-proline di-hydroxylation +namespace: biological_process +def: "The posttranslational modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282] +subset: gosubset_prok +xref: RESID:AA0282 +is_a: GO:0019511 ! peptidyl-proline hydroxylation + +[Term] +id: GO:0018189 +name: pyrroloquinoline quinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283] +subset: gosubset_prok +synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT [] +synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT [] +synonym: "PQQ biosynthesis" EXACT [] +synonym: "PQQ biosynthetic process" EXACT [] +synonym: "pyrroloquinoline quinone anabolism" EXACT [] +synonym: "pyrroloquinoline quinone biosynthesis" EXACT [] +synonym: "pyrroloquinoline quinone formation" EXACT [] +synonym: "pyrroloquinoline quinone synthesis" EXACT [] +synonym: "pyrroloquinoline-quinone biosynthesis" EXACT [] +synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT [] +xref: RESID:AA0283 +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018190 +name: protein amino acid octanoylation +namespace: biological_process +def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0018191 +name: peptidyl-serine octanoylation +namespace: biological_process +def: "The posttranslational octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290] +subset: gosubset_prok +xref: RESID:AA0290 +is_a: GO:0018190 ! protein amino acid octanoylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018192 +name: enzyme active site formation via L-cysteine persulfide +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. A persulfurated cysteine promotes active site reactivity in Azotobacter vinelandii Rhodanese." [PMID:11592406, RESID:AA0269] +subset: gosubset_prok +synonym: "enzyme active site formation via L-cysteine persulphide" EXACT [] +xref: RESID:AA0269 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018193 +name: peptidyl-amino acid modification +namespace: biological_process +def: "The alteration of an amino acid residue in a peptide." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0018194 +name: peptidyl-alanine modification +namespace: biological_process +def: "The modification of peptidyl-alanine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018195 +name: peptidyl-arginine modification +namespace: biological_process +def: "The modification of peptidyl-arginine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018196 +name: peptidyl-asparagine modification +namespace: biological_process +def: "The modification of peptidyl-asparagine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018197 +name: peptidyl-aspartic acid modification +namespace: biological_process +def: "The modification of peptidyl-aspartic acid." [GOC:ma] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018198 +name: peptidyl-cysteine modification +namespace: biological_process +def: "The modification of peptidyl-cysteine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018199 +name: peptidyl-glutamine modification +namespace: biological_process +def: "The modification of peptidyl-glutamine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018200 +name: peptidyl-glutamic acid modification +namespace: biological_process +def: "The modification of peptidyl-glutamic acid." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018201 +name: peptidyl-glycine modification +namespace: biological_process +def: "The modification of peptidyl-glycine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018202 +name: peptidyl-histidine modification +namespace: biological_process +def: "The modification of peptidyl-histidine." [GOC:ma] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018203 +name: peptidyl-isoleucine modification +namespace: biological_process +def: "The modification of peptidyl-isoleucine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018204 +name: peptidyl-leucine modification +namespace: biological_process +def: "The modification of peptidyl-leucine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018205 +name: peptidyl-lysine modification +namespace: biological_process +def: "The modification of peptidyl-lysine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018206 +name: peptidyl-methionine modification +namespace: biological_process +def: "The modification of peptidyl-methionine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018207 +name: peptidyl-phenylalanine modification +namespace: biological_process +def: "The modification of peptidyl-phenylalanine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018208 +name: peptidyl-proline modification +namespace: biological_process +def: "The modification of peptidyl-proline." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018209 +name: peptidyl-serine modification +namespace: biological_process +def: "The modification of peptidyl-serine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018210 +name: peptidyl-threonine modification +namespace: biological_process +def: "The modification of peptidyl-threonine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018211 +name: peptidyl-tryptophan modification +namespace: biological_process +def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018212 +name: peptidyl-tyrosine modification +namespace: biological_process +def: "The modification of peptidyl-tyrosine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018213 +name: peptidyl-valine modification +namespace: biological_process +def: "The modification of peptidyl-valine." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018214 +name: protein amino acid carboxylation +namespace: biological_process +def: "The addition of a carboxy group to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018215 +name: protein amino acid phosphopantetheinylation +namespace: biological_process +def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018216 +name: peptidyl-arginine methylation +namespace: biological_process +alt_id: GO:0018017 +def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006479 ! protein amino acid methylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018217 +name: peptidyl-aspartic acid phosphorylation +namespace: biological_process +def: "The posttranslational phosphorylation of peptidyl-aspartic acid." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0018218 +name: peptidyl-cysteine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034] +subset: gosubset_prok +xref: RESID:AA0034 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018219 +name: peptidyl-cysteine S-acetylation +namespace: biological_process +def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056] +subset: gosubset_prok +xref: RESID:AA0056 +is_a: GO:0018533 ! peptidyl-cysteine acetylation + +[Term] +id: GO:0018220 +name: peptidyl-threonine palmitoylation +namespace: biological_process +def: "The palmitoylation of peptidyl-threonine to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079] +subset: gosubset_prok +xref: RESID:AA0079 +is_a: GO:0018210 ! peptidyl-threonine modification +is_a: GO:0018318 ! protein amino acid palmitoylation + +[Term] +id: GO:0018221 +name: peptidyl-serine palmitoylation +namespace: biological_process +def: "The palmitoylation of peptidyl-serine to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0080] +subset: gosubset_prok +xref: RESID:AA0080 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018318 ! protein amino acid palmitoylation + +[Term] +id: GO:0018222 +name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The, presumably, posttranslational modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101] +subset: gosubset_prok +synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT [] +xref: RESID:AA0101 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018226 +name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102] +subset: gosubset_prok +synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0102 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018347 ! protein amino acid farnesylation + +[Term] +id: GO:0018227 +name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103] +subset: gosubset_prok +synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0103 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018347 ! protein amino acid farnesylation + +[Term] +id: GO:0018228 +name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104] +subset: gosubset_prok +synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0104 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018348 ! protein amino acid geranylgeranylation + +[Term] +id: GO:0018229 +name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105] +subset: gosubset_prok +synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0105 +is_a: GO:0018351 ! peptidyl-cysteine esterification + +[Term] +id: GO:0018230 +name: peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-palmitoyl-L-cysteine; the palmitate group represents a mixture of saturated and unsaturated fatty acids." [RESID:AA0106] +subset: gosubset_prok +synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0106 +is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine +is_a: GO:0018318 ! protein amino acid palmitoylation + +[Term] +id: GO:0018231 +name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The co- or posttranslational modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107] +subset: gosubset_prok +synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0107 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018232 +name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine +namespace: biological_process +def: "The posttranslation modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108] +subset: gosubset_prok +xref: RESID:AA0108 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0018233 +name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine +namespace: biological_process +def: "The posttranslation modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109] +subset: gosubset_prok +xref: RESID:AA0109 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018234 +name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine +namespace: biological_process +def: "The posttranslational thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113] +subset: gosubset_prok +xref: RESID:AA0113 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018235 +name: peptidyl-lysine carboxylation +namespace: biological_process +def: "The posttranslational modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114] +subset: gosubset_prok +xref: RESID:AA0114 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018214 ! protein amino acid carboxylation + +[Term] +id: GO:0018236 +name: ribulose-bisphosphate carboxylase activase activity +namespace: molecular_function +xref: EC:6.3.-.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0018237 +name: urease activase activity +namespace: molecular_function +xref: EC:6.3.-.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0018238 +name: peptidyl-lysine carboxyethylation +namespace: biological_process +alt_id: GO:0018239 +def: "The posttranslational modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115] +subset: gosubset_prok +synonym: "protein amino acid carboxyethylation" EXACT [] +xref: RESID:AA0115 +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018240 +name: protein amino acid S-linked glycosylation via cysteine +namespace: biological_process +def: "The posttranslational glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152] +subset: gosubset_prok +xref: RESID:AA0152 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018280 ! protein amino acid S-linked glycosylation + +[Term] +id: GO:0018241 +name: protein amino acid O-linked glycosylation via hydroxylysine +namespace: biological_process +def: "The posttranslational glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153] +subset: gosubset_prok +xref: RESID:AA0153 +is_a: GO:0006493 ! protein amino acid O-linked glycosylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018242 +name: protein amino acid O-linked glycosylation via serine +namespace: biological_process +def: "The posttranslational glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154] +subset: gosubset_prok +xref: RESID:AA0154 +is_a: GO:0006493 ! protein amino acid O-linked glycosylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018243 +name: protein amino acid O-linked glycosylation via threonine +namespace: biological_process +def: "The posttranslational glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155] +subset: gosubset_prok +xref: RESID:AA0155 +is_a: GO:0006493 ! protein amino acid O-linked glycosylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018244 +name: protein amino acid N-linked glycosylation via tryptophan +namespace: biological_process +def: "The posttranslational glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; it is uncertain whether this is an N-glycoside linkage (as indicated), and which particular hexose is involved." [RESID:AA0156] +subset: gosubset_prok +xref: RESID:AA0156 +is_a: GO:0006487 ! protein amino acid N-linked glycosylation +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018245 +name: protein amino acid O-linked glycosylation via tyrosine +namespace: biological_process +def: "The posttranslational glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157] +subset: gosubset_prok +xref: RESID:AA0157 +is_a: GO:0006493 ! protein amino acid O-linked glycosylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018246 +name: protein-coenzyme A linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018065 ! protein-cofactor linkage + +[Term] +id: GO:0018247 +name: protein-phosphoribosyl dephospho-coenzyme A linkage +namespace: biological_process +def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167] +subset: gosubset_prok +xref: RESID:AA0167 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018246 ! protein-coenzyme A linkage + +[Term] +id: GO:0018248 +name: enzyme active site formation via S-sulfo-L-cysteine +namespace: biological_process +def: "The transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] +subset: gosubset_prok +synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT [] +xref: RESID:AA0171 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018249 +name: protein amino acid dehydration +namespace: biological_process +def: "The removal of a water group from a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018250 +name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine +namespace: biological_process +def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181] +subset: gosubset_prok +synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT [] +synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT [] +synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT [] +xref: RESID:AA0181 +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0018194 ! peptidyl-alanine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018249 ! protein amino acid dehydration + +[Term] +id: GO:0018251 +name: peptidyl-tyrosine dehydrogenation +namespace: biological_process +def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183] +comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'. +subset: gosubset_prok +xref: RESID:AA0183 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018249 ! protein amino acid dehydration + +[Term] +id: GO:0018252 +name: peptide cross-linking via L-seryl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] +xref: RESID:AA0184 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0018253 +name: peptide cross-linking via 5-imidazolinone glycine +namespace: biological_process +def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188] +subset: gosubset_prok +synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0184 +xref: RESID:AA0187 +xref: RESID:AA0188 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018254 +name: peptidyl-tyrosine adenylylation +namespace: biological_process +def: "The posttranslational adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203] +subset: gosubset_prok +synonym: "peptidyl-tyrosine adenylation" EXACT [] +xref: RESID:AA0203 +is_a: GO:0018117 ! protein amino acid adenylylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018255 +name: peptide cross-linking via S-glycyl-L-cysteine +namespace: biological_process +def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [RESID:AA0206] +subset: gosubset_prok +xref: RESID:AA0206 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018256 +name: protein amino acid formylation +namespace: biological_process +def: "The addition of a formyl group to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0018257 +name: peptidyl-lysine formylation +namespace: biological_process +def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211] +subset: gosubset_prok +xref: RESID:AA0211 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018256 ! protein amino acid formylation + +[Term] +id: GO:0018258 +name: protein amino acid O-linked glycosylation via hydroxyproline +namespace: biological_process +def: "The posttranslational glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212] +subset: gosubset_prok +xref: RESID:AA0212 +is_a: GO:0006493 ! protein amino acid O-linked glycosylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0018259 +name: RNA-protein covalent cross-linking via peptidyl-serine +namespace: biological_process +def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213] +subset: gosubset_prok +xref: RESID:AA0213 +is_a: GO:0018144 ! RNA-protein covalent cross-linking +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018260 +name: protein amino acid guanylylation +namespace: biological_process +def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018175 ! protein amino acid nucleotidylation + +[Term] +id: GO:0018261 +name: peptidyl-lysine guanylylation +namespace: biological_process +def: "The posttranslational guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228] +subset: gosubset_prok +xref: RESID:AA0228 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018260 ! protein amino acid guanylylation + +[Term] +id: GO:0018262 +name: isopeptide cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0018149 ! peptide cross-linking + +[Term] +id: GO:0018263 +name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216] +subset: gosubset_prok +xref: RESID:AA0216 +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0018264 +name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126] +subset: gosubset_prok +xref: RESID:AA0126 +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0018265 +name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0158 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018266 +name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0159 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0018267 +name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0160 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018268 +name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0161 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018269 +name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0162 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018270 +name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0163 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0018271 +name: biotin-protein ligase activity +namespace: molecular_function +alt_id: GO:0000106 +def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah] +subset: gosubset_prok +synonym: "biotin-apoprotein ligase activity" EXACT [] +xref: EC:6.3.4.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0018272 +name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine +namespace: biological_process +def: "The posttranslation modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119] +subset: gosubset_prok +xref: RESID:AA0119 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage + +[Term] +id: GO:0018273 +name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine +namespace: biological_process +def: "The posttranslation modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120] +subset: gosubset_prok +xref: RESID:AA0120 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0018274 +name: peptide cross-linking via L-lysinoalanine +namespace: biological_process +def: "The posttranslational modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123] +subset: gosubset_prok +xref: RESID:AA0123 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018275 +name: N-terminal peptidyl-cysteine acetylation +namespace: biological_process +alt_id: GO:0017191 +def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043] +subset: gosubset_prok +synonym: "peptidyl-cysteine N-acetylation" EXACT [] +xref: RESID:AA0043 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018533 ! peptidyl-cysteine acetylation + +[Term] +id: GO:0018276 +name: isopeptide cross-linking via N6-glycyl-L-lysine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125] +comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'. +xref: RESID:AA0125 +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018262 ! isopeptide cross-linking +relationship: part_of GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0018277 +name: protein amino acid deamination +namespace: biological_process +def: "The removal of an amino group from a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0018278 +name: N-terminal peptidyl-threonine deamination +namespace: biological_process +def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129] +subset: gosubset_prok +xref: RESID:AA0129 +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018279 +name: protein amino acid N-linked glycosylation via asparagine +namespace: biological_process +def: "The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [RESID:AA0151] +subset: gosubset_prok +xref: RESID:AA0151 +is_a: GO:0006487 ! protein amino acid N-linked glycosylation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018280 +name: protein amino acid S-linked glycosylation +namespace: biological_process +def: "The posttranslational glycosylation of protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg] +subset: gosubset_prok +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0018281 +name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166] +subset: gosubset_prok +synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] +xref: RESID:AA0166 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0042082 ! GSI anchor biosynthetic process + +[Term] +id: GO:0018282 +name: metal incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg] +subset: gosubset_prok +synonym: "metal incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly + +[Term] +id: GO:0018283 +name: iron incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "iron incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018284 +name: iron incorporation into protein via tetrakis-L-cysteinyl iron +namespace: biological_process +def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136] +subset: gosubset_prok +xref: RESID:AA0136 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018285 +name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT [] +xref: RESID:AA0137 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018286 +name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide +namespace: biological_process +def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138] +comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form. +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT [] +is_obsolete: true +consider: GO:0018198 +consider: GO:0018283 + +[Term] +id: GO:0018287 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT [] +xref: RESID:AA0139 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018288 +name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0140 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018289 +name: molybdenum incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018290 +name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide +namespace: biological_process +def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141] +subset: gosubset_prok +synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT [] +xref: RESID:AA0141 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster +is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster + +[Term] +id: GO:0018291 +name: molybdenum incorporation into iron-sulfur cluster +namespace: biological_process +def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT [] +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018292 +name: molybdenum incorporation via L-cysteinyl molybdopterin +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142] +subset: gosubset_prok +xref: RESID:AA0142 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0018293 +name: protein-FAD linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018065 ! protein-cofactor linkage + +[Term] +id: GO:0018294 +name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine +namespace: biological_process +def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143] +subset: gosubset_prok +xref: RESID:AA0143 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018295 +name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine +namespace: biological_process +def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144] +subset: gosubset_prok +xref: RESID:AA0144 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018296 +name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine +namespace: biological_process +def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145] +subset: gosubset_prok +xref: RESID:AA0145 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018297 +name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine +namespace: biological_process +def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221] +subset: gosubset_prok +xref: RESID:AA0221 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018298 +name: protein-chromophore linkage +namespace: biological_process +def: "The covalent or noncovalent linking of a chromophore to a protein." [GOC:ma] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018299 +name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225] +subset: gosubset_prok +synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT [] +xref: RESID:AA0225 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018300 +name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide +namespace: biological_process +def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226] +comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist. +synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT [] +is_obsolete: true +consider: GO:0018198 +consider: GO:0018283 + +[Term] +id: GO:0018301 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon +namespace: biological_process +def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT [] +xref: RESID:AA0268 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018302 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0284 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018303 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0285 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018304 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0286 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018305 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0288 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018306 +name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0289 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018307 +name: enzyme active site formation +namespace: biological_process +def: "The modification of part of an enzyme to form the active site." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018308 +name: enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine +namespace: biological_process +def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287] +comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. +is_obsolete: true + +[Term] +id: GO:0018309 +name: protein-FMN linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018065 ! protein-cofactor linkage + +[Term] +id: GO:0018310 +name: protein-FMN linkage via S-(6-FMN)-L-cysteine +namespace: biological_process +def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220] +subset: gosubset_prok +xref: RESID:AA0220 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0018311 +name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236] +subset: gosubset_prok +synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT [] +xref: RESID:AA0236 +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018312 +name: peptidyl-serine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237] +subset: gosubset_prok +xref: RESID:AA0237 +is_a: GO:0006471 ! protein amino acid ADP-ribosylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018313 +name: peptide cross-linking via L-alanyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187] +subset: gosubset_prok +xref: RESID:AA0187 +is_a: GO:0018194 ! peptidyl-alanine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine + +[Term] +id: GO:0018314 +name: protein-pyrroloquinoline-quinone linkage +namespace: biological_process +def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283] +is_obsolete: true +replaced_by: GO:0006464 + +[Term] +id: GO:0018315 +name: molybdenum incorporation into molybdenum-molybdopterin complex +namespace: biological_process +alt_id: GO:0042041 +def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai] +subset: gosubset_prok +synonym: "molybdenum incorporation into metallo-pterin complex" EXACT [] +is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex + +[Term] +id: GO:0018316 +name: peptide cross-linking via L-cystine +namespace: biological_process +def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025] +subset: gosubset_prok +xref: RESID:AA0025 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018317 +name: protein amino acid C-linked glycosylation via tryptophan +namespace: biological_process +def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018103 ! protein amino acid C-linked glycosylation +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018318 +name: protein amino acid palmitoylation +namespace: biological_process +alt_id: GO:0018349 +def: "The covalent or non-covalent attachment of a palmitoyl moiety to a protein amino acid." [GOC:jl] +subset: gosubset_prok +is_a: GO:0018345 ! protein palmitoylation + +[Term] +id: GO:0018319 +name: protein amino acid myristoylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a myristoyl moiety to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018377 ! protein myristoylation + +[Term] +id: GO:0018320 +name: enzyme active site formation via S-methyl-L-cysteine +namespace: biological_process +def: "The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234] +subset: gosubset_prok +xref: RESID:AA0234 +is_a: GO:0018125 ! peptidyl-cysteine methylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018321 +name: protein amino acid glucuronylation +namespace: biological_process +def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0018322 +name: protein amino acid tyrosinylation +namespace: biological_process +def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018323 +name: enzyme active site formation via L-cysteine sulfinic acid +namespace: biological_process +def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262] +subset: gosubset_prok +synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT [] +xref: RESID:AA0262 +is_a: GO:0018171 ! peptidyl-cysteine oxidation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018324 +name: enzyme active site formation via L-cysteine sulfenic acid +namespace: biological_process +def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205] +subset: gosubset_prok +synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT [] +xref: RESID:AA0205 +is_a: GO:0018171 ! peptidyl-cysteine oxidation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018325 +name: enzyme active site formation via S-phospho-L-cysteine +namespace: biological_process +def: "The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034] +subset: gosubset_prok +xref: RESID:AA0034 +is_a: GO:0018218 ! peptidyl-cysteine phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018326 +name: enzyme active site formation via S-acetyl-L-cysteine +namespace: biological_process +def: "The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056] +subset: gosubset_prok +xref: RESID:AA0056 +is_a: GO:0018219 ! peptidyl-cysteine S-acetylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018327 +name: enzyme active site formation via 1'-phospho-L-histidine +namespace: biological_process +def: "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035] +subset: gosubset_prok +xref: RESID:AA0035 +is_a: GO:0018106 ! peptidyl-histidine phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018328 +name: enzyme active site formation via 3'-phospho-L-histidine +namespace: biological_process +def: "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036] +subset: gosubset_prok +xref: RESID:AA0036 +is_a: GO:0018106 ! peptidyl-histidine phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018329 +name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine +namespace: biological_process +def: "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227] +subset: gosubset_prok +xref: RESID:AA0227 +is_a: GO:0018116 ! peptidyl-lysine adenylylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018330 +name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine +namespace: biological_process +def: "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228] +subset: gosubset_prok +xref: RESID:AA0228 +is_a: GO:0018261 ! peptidyl-lysine guanylylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018331 +name: enzyme active site formation via O-phospho-L-serine +namespace: biological_process +def: "The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037] +subset: gosubset_prok +xref: RESID:AA0037 +is_a: GO:0018105 ! peptidyl-serine phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018332 +name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine +namespace: biological_process +def: "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267] +subset: gosubset_prok +xref: RESID:AA0267 +is_a: GO:0018178 ! peptidyl-threonine adenylylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018333 +name: enzyme active site formation via O-phospho-L-threonine +namespace: biological_process +def: "The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038] +subset: gosubset_prok +xref: RESID:AA0038 +is_a: GO:0018107 ! peptidyl-threonine phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018334 +name: enzyme active site formation via O4'-phospho-L-tyrosine +namespace: biological_process +def: "The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039] +subset: gosubset_prok +xref: RESID:AA0039 +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018335 +name: protein amino acid succinylation +namespace: biological_process +def: "The modification of a protein amino acid by succinylation." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018336 +name: peptidyl-tyrosine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018126 ! protein amino acid hydroxylation + +[Term] +id: GO:0018337 +name: enzyme active site formation via L-2',4',5'-topaquinone +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. +is_obsolete: true + +[Term] +id: GO:0018338 +name: protein amino acid cinnamylation +namespace: biological_process +def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0018097 + +[Term] +id: GO:0018339 +name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid +namespace: biological_process +def: "The posttranslation modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232] +subset: gosubset_prok +synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] +xref: RESID:AA0232 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018340 +name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine +namespace: biological_process +def: "The posttranslational modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264] +subset: gosubset_prok +synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT [] +synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT [] +synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT [] +xref: RESID:AA0264 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018341 +name: peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process +namespace: biological_process +subset: gosubset_prok +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT [] +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018342 +name: protein prenylation +namespace: biological_process +def: "The enzymatic addition of prenyl moieties to proteins as a posttranslational modification; geranyl, farnesyl, or geranylgeranyl groups may be added." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006497 ! protein amino acid lipidation + +[Term] +id: GO:0018343 +name: protein farnesylation +namespace: biological_process +def: "The enzymatic addition of a farnesyl moiety to a protein as a posttranslational modification." [GOC:jl] +subset: gosubset_prok +is_a: GO:0018342 ! protein prenylation + +[Term] +id: GO:0018344 +name: protein geranylgeranylation +namespace: biological_process +def: "The enzymatic addition of a geranylgeranyl moiety to a protein as a posttranslational modification." [GOC:jl] +subset: gosubset_prok +is_a: GO:0018342 ! protein prenylation + +[Term] +id: GO:0018345 +name: protein palmitoylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a palmitoyl moiety to a protein." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0018346 +name: protein amino acid prenylation +namespace: biological_process +def: "The covalent attachment of a prenyl moiety to a protein amino acid." [GOC:jl] +subset: gosubset_prok +synonym: "C-terminal protein prenylation" NARROW [] +is_a: GO:0018342 ! protein prenylation + +[Term] +id: GO:0018347 +name: protein amino acid farnesylation +namespace: biological_process +def: "The covalent attachment of a farnesyl moiety to a protein amino acid." [GOC:jl] +subset: gosubset_prok +synonym: "C-terminal protein farnesylation" NARROW [] +is_a: GO:0018343 ! protein farnesylation +is_a: GO:0018346 ! protein amino acid prenylation + +[Term] +id: GO:0018348 +name: protein amino acid geranylgeranylation +namespace: biological_process +def: "The covalent attachment of a geranylgeranyl moiety to a protein amino acid." [GOC:jl] +subset: gosubset_prok +synonym: "C-terminal protein geranylgeranylation" NARROW [] +is_a: GO:0018344 ! protein geranylgeranylation +is_a: GO:0018346 ! protein amino acid prenylation + +[Term] +id: GO:0018350 +name: protein amino acid esterification +namespace: biological_process +def: "The addition of an ester group to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018351 +name: peptidyl-cysteine esterification +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018350 ! protein amino acid esterification + +[Term] +id: GO:0018352 +name: protein-pyridoxal-5-phosphate linkage +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018065 ! protein-cofactor linkage + +[Term] +id: GO:0018353 +name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine +namespace: biological_process +alt_id: GO:0018380 +def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131] +subset: gosubset_prok +xref: RESID:AA0131 +is_a: GO:0017009 ! protein-phycocyanobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018354 +name: peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018160 ! peptidyl-pyrromethane cofactor linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018355 +name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage + +[Term] +id: GO:0018356 +name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine +namespace: biological_process +alt_id: GO:0018382 +def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258] +subset: gosubset_prok +xref: RESID:AA0258 +is_a: GO:0017008 ! protein-phycobiliviolin linkage + +[Term] +id: GO:0018357 +name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine +namespace: biological_process +alt_id: GO:0018383 +def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260] +subset: gosubset_prok +xref: RESID:AA0260 +is_a: GO:0017010 ! protein-phycourobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018358 +name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine +namespace: biological_process +alt_id: GO:0018381 +def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133] +subset: gosubset_prok +xref: RESID:AA0133 +is_a: GO:0017012 ! protein-phytochromobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018359 +name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine +namespace: biological_process +alt_id: GO:0018385 +def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266] +subset: gosubset_prok +synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT [] +xref: RESID:AA0266 +is_a: GO:0018174 ! protein-heme P460 linkage +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018360 +name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine +namespace: biological_process +alt_id: GO:0018384 +def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271] +subset: gosubset_prok +synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT [] +xref: RESID:AA0271 +is_a: GO:0018174 ! protein-heme P460 linkage +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018361 +name: peptidyl-glutamine 2-methylation +namespace: biological_process +def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273] +subset: gosubset_prok +xref: RESID:AA0273 +is_a: GO:0018364 ! peptidyl-glutamine methylation + +[Term] +id: GO:0018362 +name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester +namespace: biological_process +alt_id: GO:0019924 +def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279] +subset: gosubset_prok +synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT [] +xref: RESID:AA0279 +is_a: GO:0018186 ! peroxidase-heme linkage +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018363 +name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium +namespace: biological_process +alt_id: GO:0019925 +def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280] +subset: gosubset_prok +synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT [] +synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT [] +xref: RESID:AA0280 +is_a: GO:0018186 ! peroxidase-heme linkage +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018364 +name: peptidyl-glutamine methylation +namespace: biological_process +def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006479 ! protein amino acid methylation + +[Term] +id: GO:0018365 +name: protein-serine epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16] +synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16] +xref: EC:5.1.1.16 +xref: MetaCyc:5.1.1.16-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0018366 +name: L-amino acid racemization +namespace: biological_process +def: "The formation of a mixture of the two possible enantiomers from the L-isomer of a chiral amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0018367 +name: free L-amino acid racemization +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is not clear that this process occurs. +is_obsolete: true +consider: GO:0006520 + +[Term] +id: GO:0018376 +name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine +namespace: biological_process +def: "The posttranslational hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026] +comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. +subset: gosubset_prok +xref: RESID:AA0026 +is_a: GO:0042265 ! peptidyl-asparagine hydroxylation + +[Term] +id: GO:0018377 +name: protein myristoylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a myristoyl moiety to a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0018378 +name: cytochrome c-heme linkage via heme-L-cysteine +namespace: biological_process +def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135] +subset: gosubset_prok +synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT [] +xref: RESID:AA0135 +is_a: GO:0018063 ! cytochrome c-heme linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018379 +name: cytochrome c-heme linkage via heme-bis-L-cysteine +namespace: biological_process +def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134] +subset: gosubset_prok +synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT [] +xref: RESID:AA0134 +is_a: GO:0018063 ! cytochrome c-heme linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018386 +name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine +namespace: biological_process +def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274] +subset: gosubset_prok +xref: RESID:AA0274 +is_a: GO:0018060 ! N-terminal peptidyl-cysteine deamination + +[Term] +id: GO:0018387 +name: N-terminal peptidyl-amino acid deamination to pyruvic acid +namespace: biological_process +def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] +subset: gosubset_prok +xref: RESID:AA0127 +is_a: GO:0018059 ! N-terminal peptidyl-serine deamination +is_a: GO:0018060 ! N-terminal peptidyl-cysteine deamination +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018388 +name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine +namespace: biological_process +def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275] +subset: gosubset_prok +xref: RESID:AA0275 +is_a: GO:0018213 ! peptidyl-valine modification +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0018389 +name: N-terminal peptidyl-valine deamination +namespace: biological_process +def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah] +subset: gosubset_prok +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018390 +name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine +namespace: biological_process +def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072] +subset: gosubset_prok +synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] +xref: RESID:AA0072 +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018442 ! peptidyl-glutamic acid esterification + +[Term] +id: GO:0018391 +name: C-terminal peptidyl-glutamic acid tyrosinylation +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018166 ! C-terminal protein-tyrosinylation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018392 +name: glycoprotein 3-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.214] +synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT [] +synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] +synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] +xref: EC:2.4.1.214 +xref: MetaCyc:2.4.1.214-RXN +is_a: GO:0046920 ! alpha(1,3)-fucosyltransferase activity + +[Term] +id: GO:0018393 +name: internal peptidyl-lysine acetylation +namespace: biological_process +def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006475 ! internal protein amino acid acetylation +is_a: GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:0018394 +name: peptidyl-lysine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-lysine." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006473 ! protein amino acid acetylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018395 +name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine +namespace: biological_process +def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028] +subset: gosubset_prok +xref: RESID:AA0028 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0018396 +name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine +namespace: biological_process +def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235] +subset: gosubset_prok +xref: RESID:AA0235 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0018397 +name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine +namespace: biological_process +def: "The posttranslational bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174] +subset: gosubset_prok +xref: RESID:AA0174 +is_a: GO:0018075 ! peptidyl-phenylalanine bromination + +[Term] +id: GO:0018398 +name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine +namespace: biological_process +def: "The posttranslational bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175] +subset: gosubset_prok +xref: RESID:AA0175 +is_a: GO:0018075 ! peptidyl-phenylalanine bromination + +[Term] +id: GO:0018399 +name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine +namespace: biological_process +def: "The posttranslational bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176] +subset: gosubset_prok +xref: RESID:AA0176 +is_a: GO:0018075 ! peptidyl-phenylalanine bromination + +[Term] +id: GO:0018400 +name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline +namespace: biological_process +def: "The posttranslational modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029] +comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'. +subset: gosubset_prok +xref: RESID:AA0029 +is_a: GO:0019511 ! peptidyl-proline hydroxylation + +[Term] +id: GO:0018401 +name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline +namespace: biological_process +def: "The posttranslational modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030] +comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'. +subset: gosubset_prok +xref: RESID:AA0030 +is_a: GO:0019471 ! 4-hydroxyproline metabolic process +is_a: GO:0019511 ! peptidyl-proline hydroxylation + +[Term] +id: GO:0018402 +name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +namespace: biological_process +def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208] +subset: gosubset_prok +synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] +xref: RESID:AA0208 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030204 ! chondroitin sulfate metabolic process + +[Term] +id: GO:0018403 +name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +namespace: biological_process +def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209] +subset: gosubset_prok +synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] +xref: RESID:AA0209 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018404 +name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +namespace: biological_process +def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210] +subset: gosubset_prok +synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] +xref: RESID:AA0210 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018405 +name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine +namespace: biological_process +def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247] +subset: gosubset_prok +synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT [] +xref: RESID:AA0247 +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018406 +name: protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan +namespace: biological_process +alt_id: GO:0032004 +def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217] +synonym: "protein amino acid C-linked mannosylation" EXACT [] +xref: RESID:AA0217 +is_a: GO:0018317 ! protein amino acid C-linked glycosylation via tryptophan +is_a: GO:0035268 ! protein amino acid mannosylation + +[Term] +id: GO:0018407 +name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine +namespace: biological_process +def: "The posttranslational iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177] +subset: gosubset_prok +synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD [] +xref: RESID:AA0177 +is_a: GO:0018078 ! peptidyl-thyronine iodination + +[Term] +id: GO:0018408 +name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine +namespace: biological_process +def: "The posttranslational iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178] +subset: gosubset_prok +xref: RESID:AA0178 +is_a: GO:0018078 ! peptidyl-thyronine iodination + +[Term] +id: GO:0018409 +name: peptide or protein amino-terminal blocking +namespace: biological_process +subset: gosubset_prok +synonym: "peptide/protein amino-terminal blocking" EXACT [] +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0018410 +name: peptide or protein carboxyl-terminal blocking +namespace: biological_process +subset: gosubset_prok +synonym: "peptide/protein carboxyl-terminal blocking" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018411 +name: protein amino acid glucuronidation +namespace: biological_process +def: "The modification of a protein by amino acid glucuronidation." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018412 +name: protein amino acid O-glucuronidation +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018411 ! protein amino acid glucuronidation + +[Term] +id: GO:0018413 +name: peptidyl-serine O-glucuronidation +namespace: biological_process +def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291] +subset: gosubset_prok +xref: RESID:AA0291 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018412 ! protein amino acid O-glucuronidation + +[Term] +id: GO:0018414 +name: nickel incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "nickel incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018415 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0292 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018416 +name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] +subset: gosubset_prok +synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0292 +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018417 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0293 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018418 +name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] +subset: gosubset_prok +synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0 +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018419 +name: protein catenane formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0018420 +name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine +namespace: biological_process +def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294] +subset: gosubset_prok +xref: RESID:AA0294 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018421 +name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity +namespace: molecular_function +xref: EC:2.7.8.- +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0018422 +name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity +namespace: molecular_function +xref: EC:2.7.8.- +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0018423 +name: protein-leucine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester; this reaction is the methylation of peptidyl-L-leucine to form peptidyl-L-leucine methyl ester." [PMID:8514774] +synonym: "protein phosphatase methyltransferase activity" NARROW [] +xref: EC:2.1.1.- +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0018424 +name: peptidyl-glutamic acid poly-ADP-ribosylation +namespace: biological_process +def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295] +subset: gosubset_prok +xref: RESID:AA0295 +is_a: GO:0006471 ! protein amino acid ADP-ribosylation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018425 +name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296] +subset: gosubset_prok +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT [] +xref: RESID:AA0296 +is_a: GO:0042077 ! protein amino acid phosphate-linked glycosylation via serine + +[Term] +id: GO:0018426 +name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297] +subset: gosubset_prok +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT [] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT [] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT [] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT [] +xref: RESID:AA0297 +is_a: GO:0042077 ! protein amino acid phosphate-linked glycosylation via serine + +[Term] +id: GO:0018427 +name: copper incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "copper incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018428 +name: copper incorporation into copper-sulfur cluster +namespace: biological_process +def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "copper incorporation into copper-sulphur cluster" EXACT [] +is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018429 +name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide +namespace: biological_process +def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298] +subset: gosubset_prok +synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT [] +xref: RESID:AA0298 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster + +[Term] +id: GO:0018439 +name: peptidyl-leucine esterification +namespace: biological_process +alt_id: GO:0018440 +def: "The chemical reactions and pathways resulting in the formation of peptidyl-L-leucine methyl ester." [RESID:AA0299] +subset: gosubset_prok +xref: RESID:AA0299 +is_a: GO:0018203 ! peptidyl-isoleucine modification +is_a: GO:0018350 ! protein amino acid esterification + +[Term] +id: GO:0018441 +name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide +namespace: biological_process +def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT [] +xref: RESID:AA0300 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster +is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + +[Term] +id: GO:0018442 +name: peptidyl-glutamic acid esterification +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018350 ! protein amino acid esterification + +[Term] +id: GO:0018443 +name: enzyme active site formation via L-aspartic 4-phosphoric anhydride +namespace: biological_process +def: "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033] +subset: gosubset_prok +xref: RESID:AA0033 +is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0018444 +name: translation release factor complex +namespace: cellular_component +def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] +synonym: "eukaryotic peptide chain release factor" EXACT [] +synonym: "peptide chain release factor" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0018445 +name: prothoracicotrophic hormone activity +namespace: molecular_function +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0018446 +name: pinocarveol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_enzymeID:e0449] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0449 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018447 +name: chloral hydrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: chloral hydrate = 3 H+ + 2 e- + trichloroacetate OR chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0229 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018448 +name: hydroxymethylmethylsilanediol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_enzymeID:e0326] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0326 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018449 +name: 1-phenylethanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_enzymeID:e0210] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0210 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018450 +name: myrtenol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_enzymeID:e0444] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0444 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018451 +name: epoxide dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethene oxide (ethylene oxide) + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_enzymeID:e0398] +xref: EC:1.1.1.- +xref: UM-BBD_enzymeID:e0398 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018452 +name: 5-exo-hydroxycamphor dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_enzymeID:e0301] +xref: EC:1.1.1.- +xref: UM-BBD_enzymeID:e0301 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018453 +name: 2-hydroxytetrahydrofuran dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_enzymeID:e0016] +xref: EC:1.1.1.- +xref: UM-BBD_enzymeID:e0016 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018454 +name: acetoacetyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] +subset: gosubset_prok +synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36] +synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36] +synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36] +synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36] +synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36] +synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36] +synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36] +synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36] +synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36] +synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36] +xref: EC:1.1.1.36 +xref: MetaCyc:ACETOACETYL-COA-REDUCTASE-RXN +xref: UM-BBD_enzymeID:e0005 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018455 +name: alcohol dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71] +synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71] +synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71] +synonym: "retinal reductase activity" NARROW [EC:1.1.1.71] +xref: EC:1.1.1.71 +xref: MetaCyc:ALCOHOL-DEHYDROGENASE-(NAD(P)+)-RXN +xref: UM-BBD_enzymeID:e0169 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018456 +name: aryl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90] +subset: gosubset_prok +synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90] +synonym: "benzyl alcohol dehydrogenase activity" NARROW [] +synonym: "coniferyl alcohol dehydrogenase" BROAD [EC:1.1.1.90] +synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] +xref: EC:1.1.1.90 +xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0019 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018457 +name: perillyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: perillyl alcohol + NAD+ = perillyl aldehyde + NADH + H+." [EC:1.1.1.144] +synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144] +synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144] +xref: EC:1.1.1.144 +xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0459 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018458 +name: isopiperitenol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-trans-isopiperitenol + NAD+ = (-)-isopiperitenone + NADH + H+." [EC:1.1.1.223] +synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223] +xref: EC:1.1.1.223 +xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0468 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018459 +name: carveol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+." [EC:1.1.1.243] +synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243] +synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243] +xref: EC:1.1.1.243 +xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0446 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018460 +name: cyclohexanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245] +synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245] +xref: EC:1.1.1.245 +xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0165 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018461 +name: fluoren-9-ol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256] +synonym: "9-fluorenol dehydrogenase activity" EXACT [] +synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256] +xref: EC:1.1.1.256 +xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0292 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018462 +name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + NADH + H+." [EC:1.1.1.257] +synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257] +synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT [] +synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT [] +xref: EC:1.1.1.257 +xref: MetaCyc:1.1.1.257-RXN +xref: UM-BBD_enzymeID:e0239 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018463 +name: 6-hydroxyhexanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+." [EC:1.1.1.258] +synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258] +xref: EC:1.1.1.258 +xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN +xref: UM-BBD_enzymeID:e0168 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018464 +name: 3-hydroxypimeloyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypimeloyl-CoA + NAD+ = 3-oxopimeloyl-CoA + NADH + H+." [EC:1.1.1.259] +synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259] +xref: EC:1.1.1.259 +xref: MetaCyc:1.1.1.259-RXN +xref: UM-BBD_enzymeID:e0181 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018465 +name: vanillyl-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillyl alcohol + O2 = vanillin + H2O2." [EC:1.1.3.38] +synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38] +synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38] +xref: EC:1.1.3.38 +xref: MetaCyc:1.1.3.38-RXN +xref: UM-BBD_enzymeID:e0404 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0018466 +name: limonene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_enzymeID:e0463] +xref: EC:1.1.99.- +xref: UM-BBD_enzymeID:e0463 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018467 +name: formaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: formaldehyde + NAD+ + H2O = formate + NADH + H+. This enzyme does not need reduced glutathione." [EC:1.2.1.46] +subset: gosubset_prok +synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46] +synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT [] +xref: EC:1.2.1.46 +xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0120 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018468 +name: alcohol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8] +subset: gosubset_prok +synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8] +synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8] +synonym: "MDH" RELATED [EC:1.1.99.8] +synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT [] +synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8] +synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] +synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] +synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8] +xref: EC:1.1.99.8 +xref: MetaCyc:ALCOHOL-DEHYDROGENASE-(ACCEPTOR)-RXN +xref: UM-BBD_enzymeID:e0004 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018469 +name: myrtenal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_enzymeID:e0448] +xref: EC:1.2.-.- +xref: UM-BBD_enzymeID:e0448 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018470 +name: 4-hydroxybutaraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_enzymeID:e0018] +xref: EC:1.2.-.- +xref: UM-BBD_enzymeID:e0018 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018471 +name: 4-chlorobenzaldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_enzymeID:e0316] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0316 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018472 +name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_enzymeID:e0328] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0328 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018473 +name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_enzymeID:e0472] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0472 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018474 +name: 2-carboxybenzaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_enzymeID:e0331] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0331 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018475 +name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_enzymeID:e0474] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0474 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018477 +name: benzaldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7] +synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7] +synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7] +xref: EC:1.2.1.7 +xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-(NADP+)-RXN +xref: UM-BBD_enzymeID:e0079 +is_a: GO:0019115 ! benzaldehyde dehydrogenase activity + +[Term] +id: GO:0018478 +name: malonate-semialdehyde dehydrogenase (acetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18] +subset: gosubset_prok +synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18] +synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] +xref: EC:1.2.1.18 +xref: MetaCyc:1.2.1.18-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018479 +name: benzaldehyde dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28] +subset: gosubset_prok +synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28] +synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28] +xref: EC:1.2.1.28 +xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-(NAD+)-RXN +xref: UM-BBD_enzymeID:e0101 +is_a: GO:0019115 ! benzaldehyde dehydrogenase activity + +[Term] +id: GO:0018480 +name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60] +subset: gosubset_prok +synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60] +synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60] +xref: EC:1.2.1.60 +xref: MetaCyc:CHMS-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0280 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018481 +name: 4-hydroxymuconic-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + H+." [EC:1.2.1.61] +subset: gosubset_prok +synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61] +xref: EC:1.2.1.61 +xref: MetaCyc:1.2.1.61-RXN +xref: UM-BBD_enzymeID:e0204 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018482 +name: 4-formylbenzenesulfonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH + H+." [EC:1.2.1.62] +synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62] +synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT [] +synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT [] +xref: EC:1.2.1.62 +xref: MetaCyc:1.2.1.62-RXN +xref: UM-BBD_enzymeID:e0240 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018483 +name: 6-oxohexanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63] +synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63] +xref: EC:1.2.1.63 +xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN +xref: UM-BBD_enzymeID:e0171 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018484 +name: 4-hydroxybenzaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64] +synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64] +synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64] +xref: EC:1.2.1.64 +xref: MetaCyc:1.2.1.64-RXN +xref: UM-BBD_enzymeID:e0226 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018485 +name: salicylaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65] +subset: gosubset_prok +synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65] +xref: EC:1.2.1.65 +xref: MetaCyc:1.2.1.65-RXN +xref: UM-BBD_enzymeID:e0256 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018486 +name: 2-butanone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_enzymeID:e0053] +xref: EC:1.2.3.- +xref: UM-BBD_enzymeID:e0053 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0018487 +name: vanillate O-demethylase (anaerobic) activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_enzymeID:e0480] +xref: EC:1.2.3.- +xref: UM-BBD_enzymeID:e0480 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0018488 +name: aryl-aldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + H2O2." [EC:1.2.3.9] +synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9] +xref: EC:1.2.3.9 +xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0116 +is_a: GO:0004031 ! aldehyde oxidase activity + +[Term] +id: GO:0018489 +name: vanillate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillate + O2 + NADH + H+ = 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde." [EC:1.14.13.82] +comment: Note that this was EC:1.2.3.12. +subset: gosubset_prok +synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82] +synonym: "vanillate demethylase (aerobic) activity" EXACT [] +synonym: "vanillate demethylase activity" EXACT [] +synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82] +xref: EC:1.14.13.82 +xref: MetaCyc:RXN-2 +xref: UM-BBD_enzymeID:e0117 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0018490 +name: 4-hydroxyphenylpyruvate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + 1/2 O2 = 4-hydroxyphenylacetate + CO2." [EC:1.2.3.13] +synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13] +xref: EC:1.2.3.13 +xref: MetaCyc:1.2.3.13-RXN +xref: UM-BBD_enzymeID:e0244 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0018491 +name: 2-oxobutyrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2] +synonym: "2-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] +synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [EC:1.2.7.2] +synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] +synonym: "alpha-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] +synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] +xref: EC:1.2.7.2 +xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN +xref: UM-BBD_enzymeID:e0275 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018492 +name: carbon-monoxide dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] +subset: gosubset_prok +synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.99.2] +synonym: "carbon monoxide dehydrogenase activity" BROAD [] +synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.99.2] +xref: EC:1.2.99.2 +xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0415 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018493 +name: formylmethanofuran dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor." [EC:1.2.99.5] +subset: gosubset_prok +synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.5] +synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.99.5] +xref: EC:1.2.99.5 +xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0121 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018494 +name: carvone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_enzymeID:e0473] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0473 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018495 +name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0177] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0177 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018496 +name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0186] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0186 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018497 +name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_enzymeID:e0352] +synonym: "DDMS dehydrogenase activity" EXACT [] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0352 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018498 +name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0308 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018499 +name: cis-2,3-dihydrodiol DDT dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_enzymeID:e0320] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0320 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018500 +name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_enzymeID:e0381] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0381 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018501 +name: cis-chlorobenzene dihydrodiol dehydrogenase activity +namespace: molecular_function +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0411 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018502 +name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_enzymeID:e0362] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0362 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018503 +name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_enzymeID:e0380] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0380 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018504 +name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19] +subset: gosubset_prok +synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19] +synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19] +synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19] +xref: EC:1.3.1.19 +xref: MetaCyc:1.3.1.19-RXN +xref: UM-BBD_enzymeID:e0060 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018505 +name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29] +synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] +synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT [] +synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29] +synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29] +synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] +synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] +xref: EC:1.3.1.29 +xref: MetaCyc:1.3.1.29-RXN +xref: UM-BBD_enzymeID:e0122 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018506 +name: maleylacetate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32] +subset: gosubset_prok +synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32] +synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32] +xref: EC:1.3.1.32 +xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN +xref: UM-BBD_enzymeID:e0063 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018507 +name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ = phenanthrene-3,4-diol + NADH + H+." [EC:1.3.1.49] +synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49] +synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT [] +xref: EC:1.3.1.49 +xref: MetaCyc:1.3.1.49-RXN +xref: UM-BBD_enzymeID:e0322 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018508 +name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "benzoate cis-diol dehydrogenase activity" EXACT [] +xref: MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0219 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018509 +name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56] +subset: gosubset_prok +synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT [] +synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56] +synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56] +xref: EC:1.3.1.56 +xref: MetaCyc:1.3.1.56-RXN +xref: UM-BBD_enzymeID:e0134 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018510 +name: phloroglucinol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrophloroglucinol + NADP+ = phloroglucinol + NADPH + H+." [EC:1.3.1.57] +subset: gosubset_prok +synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57] +xref: EC:1.3.1.57 +xref: MetaCyc:R5-RXN +xref: UM-BBD_enzymeID:e0010 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018511 +name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ = 2,3-dihydroxy-p-cumate + NADH + H+." [EC:1.3.1.58] +subset: gosubset_prok +synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58] +xref: EC:1.3.1.58 +xref: MetaCyc:RXN-665 +xref: UM-BBD_enzymeID:e0284 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018512 +name: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59] +comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists. +synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT [] +xref: EC:1.3.1.59 +xref: MetaCyc:1.3.1.59-RXN +xref: UM-BBD_enzymeID:e0191 +is_obsolete: true + +[Term] +id: GO:0018513 +name: dibenzothiophene dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + NADH + H+." [EC:1.3.1.60] +subset: gosubset_prok +synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60] +xref: EC:1.3.1.60 +xref: MetaCyc:1.3.1.60-RXN +xref: UM-BBD_enzymeID:e0161 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018514 +name: terephthalate 1,2-cis-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH + H+." [EC:1.3.1.61] +synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.61] +xref: EC:1.3.1.61 +xref: MetaCyc:1.3.1.61-RXN +xref: UM-BBD_enzymeID:e0108 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018515 +name: pimeloyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+." [EC:1.3.1.62] +subset: gosubset_prok +synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62] +xref: EC:1.3.1.62 +xref: MetaCyc:1.3.1.62-RXN +xref: UM-BBD_enzymeID:e0179 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018516 +name: 2,4-dichlorobenzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + NADP+ + HCl = 2,4-dichlorobenzoyl-CoA + NADPH + H+." [EC:1.3.1.63] +synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.3.1.63] +xref: EC:1.3.1.63 +xref: MetaCyc:1.3.1.63-RXN +xref: UM-BBD_enzymeID:e0111 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018517 +name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+." [EC:1.3.1.64] +synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64] +xref: EC:1.3.1.64 +xref: MetaCyc:1.3.1.64-RXN +xref: UM-BBD_enzymeID:e0105 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018518 +name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H+." [EC:1.3.1.65] +synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED [] +synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65] +xref: EC:1.3.1.65 +xref: MetaCyc:RXN-643 +xref: UM-BBD_enzymeID:e0047 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018519 +name: cis-dihydroethylcatechol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + NADH + H+." [EC:1.3.1.66] +synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66] +synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT [] +xref: EC:1.3.1.66 +xref: MetaCyc:1.3.1.66-RXN +xref: UM-BBD_enzymeID:e0218 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018520 +name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67] +synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT [] +synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67] +xref: EC:1.3.1.67 +xref: MetaCyc:1.3.1.67-RXN +xref: UM-BBD_enzymeID:e0173 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018521 +name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ = 3-methylcatechol + NADH + H+ + CO2." [EC:1.3.1.68] +synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68] +xref: EC:1.3.1.68 +xref: MetaCyc:1.3.1.68-RXN +xref: UM-BBD_enzymeID:e0194 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018522 +name: benzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + donor-H2 + 2 ATP = cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate." [EC:1.3.99.15] +subset: gosubset_prok +synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.99.15] +synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase (aromatizing, ATP-forming)" EXACT [EC:1.3.99.15] +xref: EC:1.3.99.15 +xref: MetaCyc:1.3.99.15-RXN +xref: UM-BBD_enzymeID:e0176 +is_a: GO:0019109 ! acyl-CoA reductase activity + +[Term] +id: GO:0018523 +name: quinoline 2-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17] +subset: gosubset_prok +synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17] +xref: EC:1.3.99.17 +xref: MetaCyc:1.3.99.17-RXN +xref: UM-BBD_enzymeID:e0041 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018524 +name: acetophenone carboxylase activity +namespace: molecular_function +alt_id: GO:0018797 +def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_enzymeID:e0211] +xref: EC:6.4.1.- +xref: UM-BBD_enzymeID:e0211 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0018525 +name: 4-hydroxybenzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + acceptor = benzoyl-CoA + reduced acceptor." [EC:1.3.99.20] +subset: gosubset_prok +synonym: "4-hydroxybenzoyl-CoA reductase (dehydroxylating) activity" EXACT [EC:1.3.99.20] +synonym: "4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.20] +synonym: "4-hydroxybenzoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.20] +xref: EC:1.3.99.20 +xref: MetaCyc:1.3.99.20-RXN +xref: UM-BBD_enzymeID:e0159 +is_a: GO:0019109 ! acyl-CoA reductase activity + +[Term] +id: GO:0018526 +name: 2-aminobenzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_enzymeID:e0263] +xref: EC:1.4.-.- +xref: UM-BBD_enzymeID:e0263 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0018527 +name: cyclohexylamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + H2O2." [EC:1.4.3.12] +synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12] +xref: EC:1.4.3.12 +xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0477 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0018528 +name: iminodiacetate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_enzymeID:e0390] +xref: EC:1.5.-.- +xref: UM-BBD_enzymeID:e0390 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018529 +name: nitrilotriacetate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_enzymeID:e0388] +xref: EC:1.5.1.- +xref: UM-BBD_enzymeID:e0388 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018530 +name: (R)-6-hydroxynicotine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [EC:1.5.3.6] +subset: gosubset_prok +synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6] +synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT [] +synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6] +xref: EC:1.5.3.6 +xref: MetaCyc:(R)-6-HYDROXYNICOTINE-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0338 +is_a: GO:0019116 ! hydroxy-nicotine oxidase activity + +[Term] +id: GO:0018531 +name: (S)-6-hydroxynicotine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [EC:1.5.3.5] +subset: gosubset_prok +synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] +synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT [] +synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] +synonym: "L-6-hydroxynicotine oxidase activity" EXACT [] +xref: EC:1.5.3.5 +xref: MetaCyc:(S)-6-HYDROXYNICOTINE-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0339 +is_a: GO:0019116 ! hydroxy-nicotine oxidase activity + +[Term] +id: GO:0018532 +name: F433-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_enzymeID:e0265] +synonym: "F433-independent methylene-H4MPT dehydrogenase activity" EXACT [] +xref: EC:1.5.99.- +xref: UM-BBD_enzymeID:e0265 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018533 +name: peptidyl-cysteine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-cysteine." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006473 ! protein amino acid acetylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018534 +name: nitrilotriacetate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_enzymeID:e0389] +xref: EC:1.5.99.- +xref: UM-BBD_enzymeID:e0389 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018535 +name: nicotine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4] +subset: gosubset_prok +synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4] +synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4] +synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] +synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] +xref: EC:1.5.99.4 +xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0337 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018537 +name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5,N10-methylenetetrahydromethanopterin + reduced coenzyme F420 = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420." [EC:1.5.99.11] +subset: gosubset_prok +synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.99.11] +synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] +synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] +synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] +synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.99.11] +synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.99.11] +synonym: "methylenetetrahydromethanopterin reductase activity" EXACT [] +synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] +synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] +synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] +synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] +xref: EC:1.5.99.11 +xref: MetaCyc:METHELENE-THMPT-OXI-RXN +xref: UM-BBD_enzymeID:e0266 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018538 +name: epoxide carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ring opening and carboxylation of an epoxide; the reaction requires CO2 as a cosubstrate and forms a beta-keto acid as a products. An example of such a reaction is: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888] +xref: EC:1.6.-.- +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0018541 +name: p-benzoquinone reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + p-benzoquinone = NADP+ + hydroquinone." [EC:1.6.5.6] +synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6] +xref: EC:1.6.5.6 +xref: MetaCyc:1.6.5.6-RXN +xref: UM-BBD_enzymeID:e0422 +is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor + +[Term] +id: GO:0018542 +name: 2,3-dihydroxy DDT 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_enzymeID:e0315] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0315 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018543 +name: 4-amino-2-nitroso-6-nitrotoluene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_enzymeID:e0365] +xref: EC:1.6.6.- +xref: UM-BBD_enzymeID:e0365 +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0018544 +name: 4-carboxy-4'-sulfoazobenzene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_enzymeID:e0391] +synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT [] +xref: EC:1.6.6.- +xref: UM-BBD_enzymeID:e0391 +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0018545 +name: NAD(P)H nitroreductase activity +namespace: molecular_function +xref: EC:1.6.6.- +xref: UM-BBD_enzymeID:e0346 +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0018546 +name: nitrobenzene nitroreductase activity +namespace: molecular_function +xref: EC:1.6.6.- +xref: UM-BBD_enzymeID:e0245 +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0018547 +name: nitroglycerin reductase activity +namespace: molecular_function +def: "Catalysis of the removal of one or more nitrite (NO2(-)) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038] +synonym: "NG reductase activity" EXACT [] +xref: EC:1.7.3.- +xref: UM-BBD_enzymeID:e0038 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0018548 +name: pentaerythritol tetranitrate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pentaerythritol tri(or tetra)nitrate + NADPH = NADP+ + NO3- (nitrate) + pentaerythritol di(or tri)nitrate." [UM-BBD_enzymeID:e0035] +xref: EC:1.7.99.- +xref: UM-BBD_enzymeID:e0035 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0018549 +name: methanethiol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2." [EC:1.8.3.4] +synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4] +synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4] +synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4] +synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4] +synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4] +xref: EC:1.8.3.4 +xref: MetaCyc:METHANETHIOL-OXIDASE-RXN +xref: UM-BBD_enzymeID:e0153 +is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0018550 +name: tetrachloro-p-hyrodoquinone reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: organohalide + 2 GSH = GSSG + HCl + RH. Substrates are 2,3,5,6-tetrachlorohydroquinone (TeCH) (forms 2,3,6-trichlorohydroquinone (TrCH)) and 2,3,6-trichlorohydroquinone (TrCH) (forms 2,6-dichlorohydroquinone (DiCH))." [UM-BBD_enzymeID:e0251] +xref: EC:1.8.99.- +xref: UM-BBD_enzymeID:e0251 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0018551 +name: hydrogensulfite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: O3S-S-SO3(2-) + acceptor + 2 H2O + OH- = 3 HSO3(-) + reduced acceptor." [EC:1.8.99.3] +subset: gosubset_prok +synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3] +synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3] +synonym: "desulforubidin activity" NARROW [EC:1.8.99.3] +synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3] +synonym: "dissimilatory sulfite reductase activity" EXACT [] +synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3] +synonym: "hydrogensulphite reductase activity" EXACT [] +synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3] +synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3] +xref: EC:1.8.99.3 +xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN +xref: UM-BBD_enzymeID:e0416 +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0018552 +name: methyl-coenzyme-M reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl-coenzyme-M + HTP = CoM-S-S-HTP + methane." [UM-BBD_enzymeID:e0267] +xref: EC:1.12.99.- +xref: UM-BBD_enzymeID:e0267 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0018553 +name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0309 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0018554 +name: 1,2-dihydroxynaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0255 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0018555 +name: phenanthrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ = cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_enzymeID:e0321] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0321 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018556 +name: 2,2',3-trihydroxybiphenyl dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0032 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018557 +name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_enzymeID:e0295] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0295 +is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity + +[Term] +id: GO:0018558 +name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_enzymeID:e0044] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0044 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018559 +name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_enzymeID:e0313] +synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT [] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0313 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018560 +name: protocatechuate 3,4-dioxygenase type II activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_enzymeID:e0385] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0385 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018561 +name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_enzymeID:e0324] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0324 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018562 +name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_enzymeID:e0294] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0294 +is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity + +[Term] +id: GO:0018563 +name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_enzymeID:e0220] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0220 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018564 +name: carbazole 1,9a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_enzymeID:e0323] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0323 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018565 +name: dihydroxydibenzothiophene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0162] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0162 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018566 +name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0250] +synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT [] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0250 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018567 +name: styrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_enzymeID:e0200] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0200 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018568 +name: 3,4-dihydroxyphenanthrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_enzymeID:e0345] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0345 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018569 +name: hydroquinone 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0203] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0203 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018570 +name: p-cumate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_enzymeID:e0270] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0270 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018571 +name: 2,3-dihydroxy-p-cumate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_enzymeID:e0285] +subset: gosubset_prok +synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] +synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] +xref: EC:1.13.11.- +xref: MetaCyc:RXN-666 +xref: UM-BBD_enzymeID:e0285 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018572 +name: 3,5-dichlorocatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H + 2,4-dichloro-cis,cis-muconate." [UM-BBD_enzymeID:e0231] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0231 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018573 +name: 2-aminophenol 1,6-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_enzymeID:e0247] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0247 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018574 +name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0422 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018575 +name: chlorocatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_enzymeID:e0419] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0419 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018576 +name: catechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1] +subset: gosubset_prok +synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1] +synonym: "catechase activity" RELATED [EC:1.13.11.1] +synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1] +synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] +synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] +synonym: "CD I" RELATED [EC:1.13.11.1] +synonym: "CD II" RELATED [EC:1.13.11.1] +synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1] +synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1] +xref: EC:1.13.11.1 +xref: MetaCyc:CATECHOL-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0064 +is_a: GO:0019114 ! catechol dioxygenase activity + +[Term] +id: GO:0018577 +name: catechol 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2] +subset: gosubset_prok +synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2] +synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2] +synonym: "catechol oxygenase" EXACT [EC:1.13.11.2] +synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2] +synonym: "cato2ase activity" RELATED [EC:1.13.11.2] +synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2] +synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2] +xref: EC:1.13.11.2 +xref: MetaCyc:CATECHOL-2\,3-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0156 +is_a: GO:0019114 ! catechol dioxygenase activity + +[Term] +id: GO:0018578 +name: protocatechuate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3] +subset: gosubset_prok +synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3] +synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3] +synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3] +synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3] +synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3] +xref: EC:1.13.11.3 +xref: MetaCyc:PROTOCATECHUATE-3\,4-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0114 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018579 +name: protocatechuate 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8] +subset: gosubset_prok +synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8] +synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8] +synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8] +synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8] +xref: EC:1.13.11.8 +xref: MetaCyc:PROTOCATECHUATE-4\,5-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0115 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018580 +name: 2-nitropropane dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 2-nitropropane + O2 = 2 acetone + 2 NO2(-) (nitrite)." [EC:1.13.11.32] +subset: gosubset_prok +synonym: "2-nitropropane:oxygen 2-oxidoreductase activity" EXACT [EC:1.13.11.32] +synonym: "2-NPD activity" EXACT [EC:1.13.11.32] +synonym: "nitroalkane oxidase activity" EXACT [EC:1.13.11.32] +xref: EC:1.13.11.32 +xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0387 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018581 +name: hydroxyquinol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37] +subset: gosubset_prok +synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37] +synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37] +xref: EC:1.13.11.37 +xref: MetaCyc:HYDROXYQUINOL-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0207 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018582 +name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38] +synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT [] +synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38] +synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38] +synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38] +xref: EC:1.13.11.38 +xref: MetaCyc:1.13.11.38-RXN +xref: UM-BBD_enzymeID:e0329 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018583 +name: biphenyl-2,3-diol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39] +subset: gosubset_prok +synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD [] +synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39] +synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39] +synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39] +xref: EC:1.13.11.39 +xref: MetaCyc:BIPHENYL-2\,3-DIOL-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0127 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018584 +name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_enzymeID:e0276] +xref: EC:1.13.99.- +xref: UM-BBD_enzymeID:e0276 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0018585 +name: fluorene oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_enzymeID:e0291] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0291 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018586 +name: mono-butyltin dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyltin (MBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_enzymeID:e0407] +synonym: "MBT dioxygenase activity" EXACT [] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0407 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018587 +name: limonene 8-monooxygenase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0466 +is_obsolete: true +replaced_by: GO:0019113 + +[Term] +id: GO:0018588 +name: tri-n-butyltin dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tri-n-butyltin (TBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_enzymeID:e0349] +synonym: "TBT dioxygenase activity" EXACT [] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0349 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018589 +name: di-n-butyltin dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibutyltin (DBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_enzymeID:e0360] +synonym: "DBT dioxygenase activity" EXACT [] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0360 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018590 +name: methylsilanetriol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_enzymeID:e0343] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0343 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018591 +name: methyl tertiary butyl ether 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] +synonym: "MTBE 3-monooxygenase activity" EXACT [] +xref: EC:1.14.-.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018592 +name: 4-nitrocatechol 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + NO2(-) (nitrite) + 1,2,4-benzenetriol." [UM-BBD_enzymeID:e0206] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0206 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018593 +name: 4-chlorophenoxyacetate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_enzymeID:e0234] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0234 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018594 +name: tert-butyl alcohol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tert-butyl alcohol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] +xref: EC:1.14.-.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018595 +name: alpha-pinene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_enzymeID:e0475] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0475 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018596 +name: dimethylsilanediol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_enzymeID:e0288] +synonym: "DMSD hydroxylase activity" EXACT [] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0288 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018597 +name: ammonia monooxygenase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0061 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018598 +name: hydroxymethylsilanetriol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_enzymeID:e0348] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0348 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018599 +name: 2-hydroxyisobutyrate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_enzymeID:e0410] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0410 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018600 +name: alpha-pinene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_enzymeID:e0441] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0441 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018601 +name: 4-nitrophenol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-nitrophenol + O2 + NADH + H+ = H2O + 4-nitrocatechol + NAD+." [EC:1.14.13.29, UM-BBD_enzymeID:e0205] +synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29] +synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29] +synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29] +xref: EC:1.14.13.29 +xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0205 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018602 +name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid = glyoxylate + 2,4-dichlorophenol." [UM-BBD_enzymeID:e0230] +xref: EC:1.14.11.- +xref: UM-BBD_enzymeID:e0230 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0018603 +name: nitrobenzene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + NO2(-) (nitrite) + catechol." [UM-BBD_enzymeID:e0248] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0248 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018604 +name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_enzymeID:e0392] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0392 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018605 +name: 2-aminobenzenesulfonate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + H+ + O2 = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_enzymeID:e0241] +synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT [] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0241 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018606 +name: benzenesulfonate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_enzymeID:e0242] +synonym: "benzenesulphonate dioxygenase activity" EXACT [] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0242 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018607 +name: 1-indanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_enzymeID:e0298] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0298 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018608 +name: 1-indanone dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_enzymeID:e0296] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0296 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018609 +name: chlorobenzene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0062 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018610 +name: dibenzofuran 4,4a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN] +xref: EC:1.14.12.- +xref: MetaCyc:R606-RXN +xref: UM-BBD_enzymeID:e0030 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018611 +name: toluate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0190 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018612 +name: dibenzothiophene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_enzymeID:e0160] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0160 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018613 +name: 9-fluorenone dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_enzymeID:e0293] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0293 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018614 +name: ethylbenzene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_enzymeID:e0217] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0217 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018615 +name: 2-indanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_enzymeID:e0299] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0299 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018616 +name: trihydroxytoluene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_enzymeID:e0074] +xref: EC:1.14.12.- +xref: MetaCyc:R305-RXN +xref: UM-BBD_enzymeID:e0074 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018617 +name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_enzymeID:e0393] +synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT [] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0393 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018618 +name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1] +subset: gosubset_prok +synonym: "AntA" RELATED [] +synonym: "AntB" RELATED [] +synonym: "AntC" RELATED [] +synonym: "anthranilate 1,2-dioxygenase" RELATED [] +synonym: "anthranilate dioxygenase activity" EXACT [] +synonym: "anthranilate dioxygenase reductase" NARROW [] +synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1] +synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1] +synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1] +synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1] +xref: EC:1.14.12.1 +xref: MetaCyc:1.14.12.1-RXN +xref: UM-BBD_enzymeID:e0371 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018619 +name: benzene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.3] +subset: gosubset_prok +synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3] +synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3] +synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3] +xref: EC:1.14.12.3 +xref: MetaCyc:BENZENE-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0059 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018620 +name: phthalate 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+." [EC:1.14.12.7] +subset: gosubset_prok +synonym: "PDO activity" EXACT [EC:1.14.12.7] +synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7] +synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7] +xref: EC:1.14.12.7 +xref: MetaCyc:PHTHALATE-4\,5-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0104 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018621 +name: 4-sulfobenzoate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + SO3(2-) (sulfite) + NAD+." [EC:1.14.12.8] +synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8] +synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8] +synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8] +synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT [] +xref: EC:1.14.12.8 +xref: MetaCyc:4-SULFOBENZOATE-3\,4-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0128 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018622 +name: 4-chlorophenylacetate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorophenyl acetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+." [EC:1.14.12.9] +synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9] +xref: EC:1.14.12.9 +xref: MetaCyc:1.14.12.9-RXN +xref: UM-BBD_enzymeID:e0290 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018623 +name: benzoate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10] +subset: gosubset_prok +synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10] +synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10] +synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10] +synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10] +synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10] +xref: EC:1.14.12.10 +xref: MetaCyc:BENZOATE-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0154 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018624 +name: toluene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.11] +synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11] +synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11] +synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11] +xref: EC:1.14.12.11 +xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0155 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018625 +name: naphthalene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12] +subset: gosubset_prok +synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12] +synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12] +synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12] +xref: EC:1.14.12.12 +xref: MetaCyc:NAPHTHALENE-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0002 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018626 +name: 2-chlorobenzoate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13] +subset: gosubset_prok +synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13] +synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT [] +xref: EC:1.14.12.13 +xref: MetaCyc:2-CHLOROBENZOATE-1\,2-DIOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0036 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018627 +name: 2-aminobenzenesulfonate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminobenzenesulfonate + NADH + H+ + O2 = 2,3-dihydroxybenzenesulfonate + NH3 + NAD+." [EC:1.14.12.14] +synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14] +synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT [] +synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14] +xref: EC:1.14.12.14 +xref: MetaCyc:2ASDOSALCAL-RXN +xref: UM-BBD_enzymeID:e0192 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018628 +name: terephthalate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+." [EC:1.14.12.15] +synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] +synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] +synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15] +xref: EC:1.14.12.15 +xref: MetaCyc:1.14.12.15-RXN +xref: UM-BBD_enzymeID:e0107 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018629 +name: 2-hydroxyquinoline 5,6-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16] +synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT [] +synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] +synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] +synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16] +xref: EC:1.14.12.16 +xref: MetaCyc:1.14.12.16-RXN +xref: UM-BBD_enzymeID:e0046 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018630 +name: 3,5-xylenol methylhydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_enzymeID:e0287] +xref: EC:1.14.13.- +xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN +xref: UM-BBD_enzymeID:e0287 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018631 +name: phenylacetate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_enzymeID:e0197] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0197 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018632 +name: 4-nitrophenol 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + NO2(-) (nitrite) + p-benzoquinone." [UM-BBD_enzymeID:e0201] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0201 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018633 +name: dimethyl sulfide monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_enzymeID:e0189] +synonym: "dimethyl sulphide monooxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0189 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018634 +name: alpha-pinene monooxygenase [NADH] activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_enzymeID:e0443] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0443 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018635 +name: limonene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-(4R)-limonene + NADH + O2 = NAD+ + OH- + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0462 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018636 +name: phenanthrene 9,10-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_enzymeID:e0334] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0334 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018637 +name: 1-hydroxy-2-naphthoate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_enzymeID:e0332] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0332 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018638 +name: toluene 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0225 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018639 +name: xylene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = benzyl alcohol or xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0172 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018640 +name: dibenzothiophene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621] +xref: EC:1.14.13.- +xref: MetaCyc:RXN-621 +xref: UM-BBD_enzymeID:e0214 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018641 +name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_enzymeID:e0043] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0043 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018642 +name: chlorophenol 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0252 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018643 +name: carbon disulfide oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_enzymeID:e0401] +synonym: "carbon disulphide oxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0401 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018644 +name: toluene 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222] +xref: EC:1.14.13.- +xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0222 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018645 +name: alkene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69] +synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69] +synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69] +xref: EC:1.14.13.69 +xref: MetaCyc:1.14.13.69-RXN +xref: UM-BBD_enzymeID:e0039 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018646 +name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_enzymeID:e0464] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0464 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018647 +name: phenanthrene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0333 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018648 +name: methanesulfonic acid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanesulfonic acid + O2 + NADH = OH- + NAD+ + sulfurous acid + formaldehyde." [UM-BBD_enzymeID:e0264] +synonym: "methanesulphonic acid monooxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0264 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018649 +name: tetrahydrofuran hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_enzymeID:e0015] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0015 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018650 +name: styrene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_enzymeID:e0195] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0195 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018651 +name: toluene-4-sulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_enzymeID:e0243] +synonym: "toluene-4-sulphonate monooxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0243 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018652 +name: toluene-sulfonate methyl-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_enzymeID:e0238] +synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0238 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018653 +name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0042 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018654 +name: 2-hydroxy-phenylacetate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_enzymeID:e0198] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0198 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018655 +name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_enzymeID:e0304] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0304 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018656 +name: phenanthrene 3,4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_enzymeID:e0347] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0347 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018657 +name: toluene 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224] +xref: EC:1.14.13.- +xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0224 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018658 +name: salicylate 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1] +subset: gosubset_prok +synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1] +synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1] +synonym: "salicylate hydroxylase activity" EXACT [] +synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1] +synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1] +synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1] +xref: EC:1.14.13.1 +xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0149 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018659 +name: 4-hydroxybenzoate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2] +subset: gosubset_prok +synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2] +synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2] +synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2] +synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2] +synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] +synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2] +synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2] +synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2] +synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2] +synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] +xref: EC:1.14.13.2 +xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0084 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018660 +name: 4-hydroxyphenylacetate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [EC:1.14.13.3] +subset: gosubset_prok +synonym: "4 HPA 3-hydroxylase activity" EXACT [EC:1.14.13.3] +synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" EXACT [] +synonym: "4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.3] +synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" EXACT [EC:1.14.13.3] +synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" EXACT [EC:1.14.13.3] +synonym: "p-hydroxyphenylacetate hydroxylase activity" EXACT [EC:1.14.13.3] +xref: EC:1.14.13.3 +xref: MetaCyc:1.14.13.3-RXN +xref: UM-BBD_enzymeID:e0150 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018661 +name: orcinol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: orcinol + NADH + H+ + O2 = 2,3,5-trihydroxytoluene + NAD+ + H2O." [EC:1.14.13.6] +synonym: "orcinol hydroxylase activity" EXACT [] +synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6] +xref: EC:1.14.13.6 +xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0073 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018662 +name: phenol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7] +subset: gosubset_prok +synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7] +synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7] +synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7] +xref: EC:1.14.13.7 +xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0208 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018663 +name: 2,6-dihydroxypyridine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O." [EC:1.14.13.10] +synonym: "2,6-dihydroxypyridine oxidase activity" EXACT [] +synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10] +xref: EC:1.14.13.10 +xref: MetaCyc:1.14.13.10-RXN +xref: UM-BBD_enzymeID:e0340 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018664 +name: benzoate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O." [EC:1.14.13.12] +synonym: "4-hydroxybenzoic hydroxylase activity" EXACT [] +synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.13.12] +synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.12] +synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.13.12] +synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.13.12] +synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.13.12] +synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.13.12] +synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.13.12] +xref: EC:1.14.13.12 +xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0414 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018665 +name: 4-hydroxyphenylacetate 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18] +synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18] +synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT [] +synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18] +synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18] +synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18] +xref: EC:1.14.13.18 +xref: MetaCyc:1.14.13.18-RXN +xref: UM-BBD_enzymeID:e0151 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018666 +name: 2,4-dichlorophenol 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20] +subset: gosubset_prok +synonym: "2,4-dichlorophenol hydroxylase activity" EXACT [] +synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20] +synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20] +xref: EC:1.14.13.20 +xref: MetaCyc:2\,4-DICHLOROPHENOL-6-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0152 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018667 +name: cyclohexanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22] +subset: gosubset_prok +synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT [] +synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22] +synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22] +synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22] +xref: EC:1.14.13.22 +xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0166 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018668 +name: 3-hydroxybenzoate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O." [EC:1.14.13.23] +synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT [] +synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23] +xref: EC:1.14.13.23 +xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0109 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018669 +name: 3-hydroxybenzoate 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O." [EC:1.14.13.24] +synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT [] +synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24] +synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24] +synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24] +xref: EC:1.14.13.24 +xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0289 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018670 +name: 4-aminobenzoate 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27] +synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27] +synonym: "4-aminobenzoate hydroxylase activity" EXACT [] +synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27] +synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27] +xref: EC:1.14.13.27 +xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0400 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018671 +name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33] +synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33] +synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT [] +synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33] +synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33] +xref: EC:1.14.13.33 +xref: MetaCyc:1.14.13.33-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018672 +name: anthranilate 3-monooxygenase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3." [EC:1.14.13.35] +synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35] +synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35] +synonym: "anthranilate hydroxylase (deaminating) activity" EXACT [] +synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35] +synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35] +xref: EC:1.14.13.35 +xref: MetaCyc:1.14.13.35-RXN +xref: UM-BBD_enzymeID:e0382 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018673 +name: anthraniloyl-CoA monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40] +subset: gosubset_prok +synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40] +synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40] +synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40] +xref: EC:1.14.13.40 +xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0370 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018674 +name: (S)-limonene 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-isopiperitenol + NADP+ + H2O." [EC:1.14.13.47] +synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.13.47] +synonym: "(-)-limonene 3-monooxygenase activity" EXACT [] +synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.13.47] +synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.47] +synonym: "limonene 3-hydroxylase activity" EXACT [] +xref: EC:1.14.13.47 +xref: MetaCyc:(-)-LIMONENE-3-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0467 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018675 +name: (S)-limonene 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48] +synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.13.48] +synonym: "(-)-limonene 6-monooxygenase activity" EXACT [] +synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.48] +synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.48] +synonym: "limonene 6-hydroxylase activity" EXACT [] +xref: EC:1.14.13.48 +xref: MetaCyc:(-)-LIMONENE-6-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0445 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018676 +name: (S)-limonene 7-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-perillyl alcohol + NADP+ + H2O." [EC:1.14.13.49] +synonym: "(-)-limonene 7-monooxygenase activity" EXACT [] +synonym: "(-)-limonene hydroxylase activity" EXACT [EC:1.14.13.49] +synonym: "(-)-limonene monooxygenase activity" EXACT [EC:1.14.13.49] +synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) activity" EXACT [EC:1.14.13.49] +synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.13.49] +synonym: "limonene hydroxylase activity" EXACT [] +xref: EC:1.14.13.49 +xref: MetaCyc:(-)-LIMONENE-7-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0458 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018677 +name: pentachlorophenol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50] +subset: gosubset_prok +synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50] +synonym: "PCB4MO activity" EXACT [EC:1.14.13.50] +synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50] +synonym: "PcpB" RELATED [EC:1.14.13.50] +synonym: "pentachlorophenol 4-monooxygenase activity" EXACT [] +synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50] +synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50] +synonym: "pentachlorophenol hydroxylase activity" EXACT [] +synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50] +xref: EC:1.14.13.50 +xref: MetaCyc:PENTACHLOROPHENOL-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0148 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018678 +name: 4-hydroxybenzoate 1-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64] +synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT [] +synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64] +xref: EC:1.14.13.64 +xref: MetaCyc:1.14.13.64-RXN +xref: UM-BBD_enzymeID:e0476 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018679 +name: dibenzothiophene-5,5-dioxide monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_enzymeID:e0215] +xref: EC:1.14.14.- +xref: UM-BBD_enzymeID:e0215 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018680 +name: deethylatrazine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_enzymeID:e0098] +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0098 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018681 +name: deisopropylatrazine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 CH3CHO + 2 deisopropyldeethylatrazine." [UM-BBD_enzymeID:e0094] +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0094 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018682 +name: atrazine monooxygenase activity +namespace: molecular_function +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0090 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018683 +name: camphor 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1] +subset: gosubset_prok +synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1] +synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT [] +synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1] +synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1] +synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1] +synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1] +xref: EC:1.14.15.1 +xref: MetaCyc:R541-RXN +xref: UM-BBD_enzymeID:e0300 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018684 +name: camphor 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2] +synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2] +synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2] +synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2] +synonym: "ketolactonase I" RELATED [EC:1.14.15.2] +synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2] +xref: EC:1.14.15.2 +xref: MetaCyc:CAMPHOR-1\,2-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0302 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018685 +name: alkane 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] +subset: gosubset_prok +synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3] +synonym: "alkane 1-hydroxylase activity" EXACT [] +synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3] +synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3] +synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3] +synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] +synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] +synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] +xref: EC:1.14.15.3 +xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0022 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018686 +name: 6-hydroxy pseudo-oxynicotine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_enzymeID:e0342] +xref: EC:1.14.18.- +xref: UM-BBD_enzymeID:e0342 +is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018687 +name: biphenyl 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD; requires Fe2+." [EC:1.14.12.18] +subset: gosubset_prok +synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18] +synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18] +xref: EC:1.14.12.18 +xref: MetaCyc:1.14.12.18-RXN +xref: UM-BBD_enzymeID:e0089 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018688 +name: DDT 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_enzymeID:e0319] +xref: EC:1.14.99.- +xref: UM-BBD_enzymeID:e0319 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0018689 +name: naphthalene disulfonate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249] +synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT [] +xref: EC:1.14.99.- +xref: UM-BBD_enzymeID:e0249 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018690 +name: 4-methoxybenzoate monooxygenase (O-demethylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methoxybenzoate + donor-H2 + O2 = 4-hydroxybenzoate + formaldehyde + acceptor + H2O." [EC:1.14.99.15] +synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15] +synonym: "4-methoxybenzoate monooxygenase activity" EXACT [] +synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15] +synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15] +synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15] +synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15] +xref: EC:1.14.99.15 +xref: MetaCyc:1.14.99.15-RXN +xref: UM-BBD_enzymeID:e0103 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018691 +name: arsenite oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: arsenite + 10 H2O = 20 H+ + 8 e- + arsenate." [UM-BBD_enzymeID:e0037] +xref: EC:1.16.-.- +xref: UM-BBD_enzymeID:e0037 +is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions + +[Term] +id: GO:0018693 +name: ethylbenzene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor." [EC:1.17.99.2] +synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2] +synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2] +xref: EC:1.17.99.2 +xref: UM-BBD_enzymeID:e0209 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0018694 +name: p-cymene methyl hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_enzymeID:e0199] +xref: EC:1.17.99.- +xref: UM-BBD_enzymeID:e0199 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0018695 +name: 4-cresol dehydrogenase (hydroxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1] +subset: gosubset_prok +synonym: "4-cresol dehydrogenase activity" EXACT [] +synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.99.1] +synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.99.1] +synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.99.1] +xref: EC:1.17.99.1 +xref: MetaCyc:1.17.99.1-RXN +xref: UM-BBD_enzymeID:e0147 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0018697 +name: carbonyl sulfide nitrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = H2S + carbon monoxide." [UM-BBD_enzymeID:e0402] +synonym: "carbonyl sulphide nitrogenase activity" EXACT [] +xref: EC:1.18.6.- +xref: UM-BBD_enzymeID:e0402 +is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor + +[Term] +id: GO:0018698 +name: vinyl chloride reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene (ethylene)." [UM-BBD_enzymeID:e0273] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0273 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018699 +name: 1,1,1-trichloroethane reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0626 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018700 +name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_enzymeID:e0450] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0450 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018701 +name: 2,5-dichlorohydroquinone reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0366 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018702 +name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_enzymeID:e0312] +synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT [] +synonym: "DDE dehalogenase activity" EXACT [] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0312 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018703 +name: 2,4-dichlorophenoxyacetate dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_enzymeID:e0233] +xref: UM-BBD_enzymeID:e0233 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018704 +name: 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0237 +is_obsolete: true + +[Term] +id: GO:0018705 +name: 1,2-dichloroethene reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272] +synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT [] +xref: UM-BBD_enzymeID:e0272 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018706 +name: pyrogallol hydroxytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2] +subset: gosubset_prok +synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2] +synonym: "pyrogallol hydroxyltransferase activity" EXACT [] +synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] +xref: EC:1.97.1.2 +xref: MetaCyc:1.97.1.2-RXN +xref: UM-BBD_enzymeID:e0009 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018707 +name: 1-phenanthrol methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_enzymeID:e0336] +xref: EC:2.1.1.- +xref: UM-BBD_enzymeID:e0336 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0018708 +name: thiol S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9] +synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9] +synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9] +synonym: "TMT" RELATED [EC:2.1.1.9] +xref: EC:2.1.1.9 +xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN +xref: Reactome:9948 +xref: UM-BBD_enzymeID:e0146 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0018710 +name: acetone carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetone + ATP + 2 H2O + CO2 = AMP + 2 phosphate + acetoacetate." [EC:6.4.1.6] +synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6] +xref: EC:6.4.1.6 +xref: MetaCyc:6.4.1.6-RXN +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0018711 +name: benzoyl acetate-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_enzymeID:e0213] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0213 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0018712 +name: 3-hydroxybutyryl-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_enzymeID:e0013] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0013 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0018713 +name: 3-ketopimelyl-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_enzymeID:e0182] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0182 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0018715 +name: 9-phenanthrol UDP-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_enzymeID:e0377] +xref: EC:2.4.1.- +xref: UM-BBD_enzymeID:e0377 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0018716 +name: 1-phenanthrol glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_enzymeID:e0356] +xref: EC:2.4.1.- +xref: UM-BBD_enzymeID:e0356 +is_a: GO:0019112 ! phenanthrol glycosyltransferase activity + +[Term] +id: GO:0018717 +name: 9-phenanthrol glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_enzymeID:e0350] +xref: EC:2.4.1.- +xref: UM-BBD_enzymeID:e0350 +is_a: GO:0019112 ! phenanthrol glycosyltransferase activity + +[Term] +id: GO:0018718 +name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_enzymeID:e0378] +xref: EC:2.4.1.- +xref: UM-BBD_enzymeID:e0378 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0018719 +name: 6-aminohexanoate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_enzymeID:e0318] +xref: EC:2.6.1.- +xref: UM-BBD_enzymeID:e0318 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0018720 +name: phenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_enzymeID:e0157] +xref: EC:2.7.1.- +xref: UM-BBD_enzymeID:e0157 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0018721 +name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_enzymeID:e0369] +synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0369 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0018722 +name: 1-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_enzymeID:e0373] +synonym: "1-phenanthrol sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0373 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018723 +name: 3-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_enzymeID:e0374] +synonym: "3-phenanthrol sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0374 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018724 +name: 4-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_enzymeID:e0375] +synonym: "4-phenanthrol sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0375 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018725 +name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_enzymeID:e0368] +synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0368 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0018726 +name: 9-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_enzymeID:e0376] +synonym: "9-phenanthrol sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0376 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018727 +name: 2-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_enzymeID:e0372] +synonym: "2-phenanthrol sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0372 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018729 +name: propionate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1] +subset: gosubset_prok +synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1] +synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1] +synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1] +synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1] +synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1] +xref: EC:2.8.3.1 +xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN +xref: UM-BBD_enzymeID:e0071 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0018730 +name: glutaconate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12] +subset: gosubset_prok +synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12] +xref: EC:2.8.3.12 +xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN +xref: UM-BBD_enzymeID:e0069 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0018731 +name: 1-oxa-2-oxocycloheptane lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_enzymeID:e0167] +xref: EC:3.1.1.- +xref: UM-BBD_enzymeID:e0167 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0018732 +name: sulfolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_enzymeID:e0384] +synonym: "sulpholactone hydrolase activity" EXACT [] +xref: EC:3.1.1.- +xref: UM-BBD_enzymeID:e0384 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0018733 +name: 3,4-dihydrocoumarin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_enzymeID:e0297] +xref: EC:3.1.1.- +xref: UM-BBD_enzymeID:e0297 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0018734 +name: butyrolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_enzymeID:e0017] +xref: EC:3.1.1.- +xref: UM-BBD_enzymeID:e0017 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0018736 +name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_enzymeID:e0187] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0187 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018737 +name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_enzymeID:e0178] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0178 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018738 +name: S-formylglutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-formylglutathione + H2O = glutathione + formate." [EC:3.1.2.12] +subset: gosubset_prok +xref: EC:3.1.2.12 +xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN +xref: UM-BBD_enzymeID:e0141 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0018739 +name: 4-hydroxybenzoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA." [EC:3.1.2.23] +subset: gosubset_prok +synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23] +synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT [] +xref: EC:3.1.2.23 +xref: MetaCyc:3.1.2.23-RXN +xref: UM-BBD_enzymeID:e0118 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0018740 +name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(2-hydroxyphenyl)benzenesulfinate + H2O = 2-hydroxybiphenyl + SO3(2-) (sulfite)." [EC:3.13.1.3] +subset: gosubset_prok +synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT [] +synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] +synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT [] +synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3] +synonym: "DszB" RELATED [EC:3.13.1.3] +synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3] +synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3] +synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3] +xref: EC:3.13.1.3 +xref: MetaCyc:RXN-624 +xref: UM-BBD_enzymeID:e0216 +is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds + +[Term] +id: GO:0018741 +name: alkyl sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dodecyl sulfate + H2O = SO4(2-) (sulfate) + H+ + 1-dodecanol." [UM-BBD_enzymeID:e0403] +synonym: "alkyl sulphatase activity" EXACT [] +xref: EC:3.1.6.- +xref: UM-BBD_enzymeID:e0403 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0018742 +name: epoxide hydrolase B activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0051 +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0018743 +name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0367] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0367 +is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity + +[Term] +id: GO:0018744 +name: limonene-1,2-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8] +subset: gosubset_prok +synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8] +xref: EC:3.3.2.8 +xref: MetaCyc:3.3.2.8-RXN +xref: UM-BBD_enzymeID:e0470 +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0018745 +name: epoxide hydrolase A activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0049 +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0018746 +name: phenanthrene-3,4-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0363] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0363 +is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity + +[Term] +id: GO:0018747 +name: phenanthrene-1,2-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0364] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0364 +is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity + +[Term] +id: GO:0018748 +name: iprodione amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_enzymeID:e0438] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0438 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0018749 +name: (3,5-dichlorophenylurea)acetate amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_enzymeID:e0440] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0440 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0018750 +name: biuret amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84] +xref: EC:3.5.1.84 +xref: MetaCyc:R469-RXN +xref: UM-BBD_enzymeID:e0088 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0018751 +name: 3,5-dichlorophenylcarboximide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_enzymeID:e0439] +xref: EC:3.5.2.- +xref: UM-BBD_enzymeID:e0439 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0018752 +name: epsilon-caprolactam lactamase activity +namespace: molecular_function +def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_enzymeID:e0317] +xref: EC:3.5.2.- +xref: UM-BBD_enzymeID:e0317 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0018753 +name: cyanuric acid amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15] +subset: gosubset_prok +xref: EC:3.5.2.15 +xref: MetaCyc:R468-RXN +xref: UM-BBD_enzymeID:e0087 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0018754 +name: ammelide aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731] +xref: EC:3.5.3.- +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018755 +name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity +namespace: molecular_function +def: "2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] +xref: EC:3.5.3.- +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018756 +name: ammeline aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] +xref: EC:3.5.3.- +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018757 +name: deisopropylhydroxyatrazine aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_enzymeID:e0092] +xref: EC:3.5.3.- +xref: UM-BBD_enzymeID:e0092 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018758 +name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_enzymeID:e0093] +xref: EC:3.5.3.- +xref: UM-BBD_enzymeID:e0093 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018759 +name: methenyltetrahydromethanopterin cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N5-formyl-5,6,7,8-tetrahydromethanopterin." [EC:3.5.4.27] +subset: gosubset_prok +synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27] +synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] +synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] +synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] +synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] +xref: EC:3.5.4.27 +xref: MetaCyc:3.5.4.27-RXN +xref: UM-BBD_enzymeID:e0140 +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0018760 +name: thiocyanate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiocyanate + H2O = NH3 + carbonyl sulfide." [UM-BBD_enzymeID:e0399] +synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8] +xref: EC:3.5.5.8 +xref: MetaCyc:RXN-1761 +xref: UM-BBD_enzymeID:e0399 +is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles + +[Term] +id: GO:0018761 +name: bromoxynil nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxy-benzoate + NH3. Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6] +subset: gosubset_prok +synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT [] +synonym: "bromoxynil-specific nitrilase activity" EXACT [] +xref: EC:3.5.5.6 +xref: MetaCyc:3.5.5.6-RXN +xref: UM-BBD_enzymeID:e0357 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0018762 +name: aliphatic nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] +subset: gosubset_prok +synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7] +xref: EC:3.5.5.7 +xref: MetaCyc:3.5.5.7-RXN +xref: UM-BBD_enzymeID:e0413 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0018763 +name: hydroxydechloroatrazine ethylaminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3] +subset: gosubset_prok +synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.99.3] +synonym: "AtzB" RELATED [EC:3.5.99.3] +synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT [] +synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.99.3] +xref: EC:3.5.99.3 +xref: MetaCyc:R122-RXN +xref: UM-BBD_enzymeID:e0085 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0018764 +name: N-isopropylammelide isopropylaminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4] +subset: gosubset_prok +synonym: "AtzC" RELATED [EC:3.5.99.4] +xref: EC:3.5.99.4 +xref: MetaCyc:R123-RXN +xref: UM-BBD_enzymeID:e0086 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0018765 +name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_enzymeID:e0223] +xref: EC:3.7.1.- +xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN +xref: UM-BBD_enzymeID:e0223 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018766 +name: dihydrophloroglucinol hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_enzymeID:e0011] +xref: EC:3.7.1.- +xref: MetaCyc:R6-RXN +xref: UM-BBD_enzymeID:e0011 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018767 +name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_enzymeID:e0102] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0102 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018768 +name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoat + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_enzymeID:e0325] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0325 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018769 +name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_enzymeID:e0221] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0221 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018770 +name: 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate + H2O = 2-(4-chlorophenyl)-3,3-dichloropropenoate." [UM-BBD_enzymeID:e0314] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0314 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018771 +name: 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity +namespace: molecular_function +alt_id: GO:0008680 +def: "Catalysis of the reaction: 2-hydroxy-6-keto-nona-2,4-dienedioate + OH- = cis-2-hydroxypenta-2,4-dienoate + succinate." [UM-BBD_enzymeID:e0310] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0310 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018772 +name: trioxoheptanoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_enzymeID:e0075] +xref: EC:3.7.1.- +xref: MetaCyc:R306-RXN +xref: UM-BBD_enzymeID:e0075 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018773 +name: acetylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetylpyruvate + H2O = acetate + pyruvate." [EC:3.7.1.6] +synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6] +xref: EC:3.7.1.6 +xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN +xref: UM-BBD_enzymeID:e0076 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018774 +name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8] +subset: gosubset_prok +synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8] +synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT [] +synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8] +xref: EC:3.7.1.8 +xref: MetaCyc:3.7.1.8-RXN +xref: UM-BBD_enzymeID:e0033 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018775 +name: 2-hydroxymuconate-semialdehyde hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9] +synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9] +synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9] +synonym: "HMSH" RELATED [EC:3.7.1.9] +synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9] +xref: EC:3.7.1.9 +xref: MetaCyc:3.7.1.9-RXN +xref: UM-BBD_enzymeID:e0139 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018776 +name: trans-chloroacrylic acid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_enzymeID:e0434] +xref: EC:3.8.1.- +xref: UM-BBD_enzymeID:e0434 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018777 +name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214] +xref: EC:3.8.1.- +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018778 +name: DL-2 haloacid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_enzymeID:e0269] +xref: EC:3.8.1.- +xref: UM-BBD_enzymeID:e0269 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018779 +name: 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +xref: EC:3.8.1.- +xref: UM-BBD_enzymeID:e0100 +is_obsolete: true + +[Term] +id: GO:0018780 +name: dichloroacetate halidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_enzymeID:e0268] +xref: EC:3.8.1.- +xref: UM-BBD_enzymeID:e0268 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018781 +name: S-triazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine -> 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330] +xref: EC:3.8.1.- +xref: UM-BBD_enzymeID:e0091 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018782 +name: cis-chloroacrylic acid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_enzymeID:e0433] +xref: EC:3.8.1.- +xref: UM-BBD_enzymeID:e0433 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018783 +name: deisopropyldeethylatrazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129] +xref: EC:3.8.1.- +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018784 +name: (S)-2-haloacid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2] +subset: gosubset_prok +synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] +synonym: "2-haloacid dehalogenase activity" EXACT [] +synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] +synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2] +synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2] +synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2] +synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] +synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2] +synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] +synonym: "L-DEX activity" EXACT [EC:3.8.1.2] +xref: EC:3.8.1.2 +xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN +xref: UM-BBD_enzymeID:e0021 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018785 +name: haloacetate dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3] +subset: gosubset_prok +synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3] +synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3] +xref: EC:3.8.1.3 +xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN +xref: UM-BBD_enzymeID:e0006 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018786 +name: haloalkane dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5] +subset: gosubset_prok +synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5] +synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5] +synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5] +xref: EC:3.8.1.5 +xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN +xref: UM-BBD_enzymeID:e0003 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018787 +name: 4-chlorobenzoyl-CoA dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7] +synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7] +xref: EC:3.8.1.7 +xref: MetaCyc:3.8.1.7-RXN +xref: UM-BBD_enzymeID:e0113 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018788 +name: atrazine chlorohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride." [EC:3.8.1.8] +subset: gosubset_prok +synonym: "AtzA" RELATED [EC:3.8.1.8] +xref: EC:3.8.1.8 +xref: MetaCyc:3.8.1.8-RXN +xref: UM-BBD_enzymeID:e0001 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018789 +name: cyclamate sulfohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + SO4(2-) (sulfate)." [EC:3.10.1.2] +synonym: "cyclamate sulfamatase activity" EXACT [] +synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2] +synonym: "cyclamate sulphohydrolase activity" EXACT [] +synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2] +synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2] +xref: EC:3.10.1.2 +xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN +xref: UM-BBD_enzymeID:e0478 +is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds + +[Term] +id: GO:0018790 +name: 2,3-dihydroxybenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = CO2 + catechol." [UM-BBD_enzymeID:e0383] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0383 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018791 +name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_enzymeID:e0286] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0286 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018792 +name: bis(4-chlorophenyl)acetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_enzymeID:e0355] +synonym: "DDA decarboxylase activity" EXACT [] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0355 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018793 +name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_enzymeID:e0358] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0358 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018794 +name: 2-hydroxyisobutyrate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_enzymeID:e0408] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0408 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018795 +name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_enzymeID:e0412] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0412 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018796 +name: 4,5-dihydroxyphthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55] +subset: gosubset_prok +synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55] +synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55] +xref: EC:4.1.1.55 +xref: MetaCyc:4\,5-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0106 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018798 +name: gallate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4,5-trihydroxybenzoate = pyrogallol + CO2." [EC:4.1.1.59] +synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59] +synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59] +synonym: "gallic acid decarboxylase activity" EXACT [] +xref: EC:4.1.1.59 +xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0008 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018799 +name: 4-hydroxybenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate = phenol + CO2." [EC:4.1.1.61] +subset: gosubset_prok +synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61] +synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61] +synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61] +xref: EC:4.1.1.61 +xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0138 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018800 +name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68, UniProtKB:Q46978] +subset: gosubset_prok +synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68] +synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT [] +synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68] +synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68] +synonym: "HpaG-2" RELATED [] +synonym: "HpaG2" RELATED [] +synonym: "OPET decarboxylase activity" EXACT [] +xref: EC:4.1.1.68 +xref: MetaCyc:4.1.1.68-RXN +xref: UM-BBD_enzymeID:e0137 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018801 +name: glutaconyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pent-2-enoyl-CoA = but-2-enoyl-CoA + CO2." [EC:4.1.1.70] +subset: gosubset_prok +synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [EC:4.1.1.70] +synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] +synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.70] +synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] +xref: EC:4.1.1.70 +xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0136 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018802 +name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_enzymeID:e0282] +xref: EC:4.1.2.- +xref: UM-BBD_enzymeID:e0282 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018803 +name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34] +synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] +synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34] +synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] +synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34] +synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT [] +xref: EC:4.1.2.34 +xref: MetaCyc:4.1.2.34-RXN +xref: UM-BBD_enzymeID:e0330 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018805 +name: benzylsuccinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + toluene = benzylsuccinate." [UM-BBD_enzymeID:e0259] +synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11] +synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11] +xref: EC:4.1.99.11 +xref: MetaCyc:RXN-863 +xref: UM-BBD_enzymeID:e0259 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0018807 +name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0185] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0185 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018808 +name: cis-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_enzymeID:e0327] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0327 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018809 +name: E-phenylitaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_enzymeID:e0262] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0262 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018810 +name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_enzymeID:e0164] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0164 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018811 +name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_enzymeID:e0175] +xref: EC:4.2.1.- +xref: MetaCyc:R266-RXN +xref: UM-BBD_enzymeID:e0175 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018812 +name: 3-hydroxyacyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291] +xref: EC:4.2.1.- +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018813 +name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E )-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0257 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018814 +name: phenylacetaldoxime dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O." [EC:4.99.1.7, UM-BBD_enzymeID:e0437] +synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7] +synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7] +synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7] +synonym: "OxdB" RELATED [EC:4.99.1.7] +synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7] +xref: EC:4.99.1.7 +xref: UM-BBD_enzymeID:e0437 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0018815 +name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = CH2CHCOCOOH + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_enzymeID:e0045] +xref: EC:4.2.1.- +xref: MetaCyc:RXN-645 +xref: UM-BBD_enzymeID:e0045 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018816 +name: 2-hydroxyisobutyrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_enzymeID:e0409] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0409 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018817 +name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_enzymeID:e0281] +subset: gosubset_prok +synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] +synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] +synonym: "HpaH" RELATED [] +xref: EC:4.2.1.- +xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN +xref: UM-BBD_enzymeID:e0281 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018818 +name: acetylene hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetaldehyde = acetylene + H2O." [EC:4.2.1.112, UM-BBD_enzymeID:e0394] +synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112] +synonym: "AH" RELATED [EC:4.2.1.112] +synonym: "AHy" RELATED [EC:4.2.1.112] +xref: EC:4.2.1.112 +xref: UM-BBD_enzymeID:e0394 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018819 +name: lactoyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54] +synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54] +synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54] +synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54] +synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54] +synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54] +synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54] +xref: EC:4.2.1.54 +xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN +xref: MetaCyc:RXN-781 +xref: UM-BBD_enzymeID:e0070 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018820 +name: cyanamide hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: urea = cyanamide + H2O." [EC:4.2.1.69] +synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69] +synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69] +xref: EC:4.2.1.69 +xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN +xref: UM-BBD_enzymeID:e0426 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018822 +name: nitrile hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84] +subset: gosubset_prok +synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84] +synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84] +synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84] +synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84] +synonym: "H-NHase activity" EXACT [EC:4.2.1.84] +synonym: "L-NHase activity" EXACT [EC:4.2.1.84] +synonym: "NHase activity" EXACT [EC:4.2.1.84] +synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84] +xref: EC:4.2.1.84 +xref: MetaCyc:NITRILE-HYDRATASE-RXN +xref: UM-BBD_enzymeID:e0067 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018823 +name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohex-1,5-dienecarbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA." [EC:4.2.1.100] +subset: gosubset_prok +synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100] +synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [] +synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100] +synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100] +synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100] +synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100] +xref: EC:4.2.1.100 +xref: MetaCyc:4.2.1.100-RXN +xref: UM-BBD_enzymeID:e0184 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018824 +name: (hydroxyamino)benzene mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_enzymeID:e0246] +synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1] +synonym: "HAB mutase activity" EXACT [EC:5.4.4.1] +synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1] +synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1] +xref: UM-BBD_enzymeID:e0246 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0018825 +name: triethanolamine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421] +xref: EC:4.3.3.- +xref: UM-BBD_enzymeID:e0421 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0018826 +name: methionine gamma-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11] +subset: gosubset_prok +synonym: "L-methioninase activity" EXACT [EC:4.4.1.11] +synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11] +synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11] +synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11] +synonym: "methioninase activity" EXACT [EC:4.4.1.11] +synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11] +synonym: "methionine lyase activity" EXACT [EC:4.4.1.11] +xref: EC:4.4.1.11 +xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN +xref: UM-BBD_enzymeID:e0305 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0018827 +name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_enzymeID:e0353] +synonym: "DDMS dehydrochlorinase activity" EXACT [] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0353 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018828 +name: halohydrin hydrogen-halide-lyase A activity +namespace: molecular_function +def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0048 +is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity + +[Term] +id: GO:0018829 +name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_enzymeID:e0351] +synonym: "DDD dehydrochlorinase activity" EXACT [] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0351 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018830 +name: gamma-hexachlorocyclohexane dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0359 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018831 +name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_enzymeID:e0425] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0425 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018832 +name: halohydrin hydrogen-halide-lyase B activity +namespace: molecular_function +def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0050 +is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity + +[Term] +id: GO:0018833 +name: DDT-dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + chloride." [EC:4.5.1.1] +synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1] +synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1] +synonym: "DDT dehydrochlorinase activity" EXACT [] +synonym: "DDT-as" RELATED [EC:4.5.1.1] +synonym: "DDT-ase activity" EXACT [EC:4.5.1.1] +synonym: "DDTase activity" EXACT [EC:4.5.1.1] +xref: EC:4.5.1.1 +xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN +xref: UM-BBD_enzymeID:e0311 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018834 +name: dichloromethane dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dichloromethane + H2O = formaldehyde + 2 chloride." [EC:4.5.1.3] +subset: gosubset_prok +synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3] +synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3] +xref: EC:4.5.1.3 +xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN +xref: UM-BBD_enzymeID:e0174 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018835 +name: carbon phosphorus lyase activity +namespace: molecular_function +alt_id: GO:0009456 +def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [UM-BBD_enzymeID:e0057] +xref: EC:4.99.1.- +xref: UM-BBD_enzymeID:e0057 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0018836 +name: alkylmercury lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2] +subset: gosubset_prok +synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2] +synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2] +synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2] +synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2] +xref: EC:4.99.1.2 +xref: MetaCyc:ALKYLMERCURY-LYASE-RXN +xref: UM-BBD_enzymeID:e0055 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0018837 +name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_enzymeID:e0344] +xref: EC:5.1.2.- +xref: UM-BBD_enzymeID:e0344 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0018838 +name: mandelate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2] +subset: gosubset_prok +xref: EC:5.1.2.2 +xref: MetaCyc:MANDELATE-RACEMASE-RXN +xref: UM-BBD_enzymeID:e0072 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0018839 +name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0163] +xref: EC:5.2.1.- +xref: UM-BBD_enzymeID:e0163 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0018842 +name: 3-carboxymuconate cycloisomerase type II activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_enzymeID:e0379] +subset: gosubset_prok +xref: EC:5.3.3.- +xref: UM-BBD_enzymeID:e0379 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0018844 +name: 2-hydroxytetrahydrofuran isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_enzymeID:e0026] +xref: EC:5.3.99.- +xref: UM-BBD_enzymeID:e0026 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0018845 +name: 2-hydroxychromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = trans-o-hydroxybenzylidenepyruvate." [UM-BBD_enzymeID:e0258] +xref: EC:5.3.99.- +xref: UM-BBD_enzymeID:e0258 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0018846 +name: styrene-oxide isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7] +synonym: "SOI activity" EXACT [EC:5.3.99.7] +synonym: "styrene oxide isomerase activity" EXACT [] +synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7] +xref: EC:5.3.99.7 +xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN +xref: UM-BBD_enzymeID:e0196 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0018847 +name: alpha-pinene lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_enzymeID:e0442] +xref: EC:5.5.1.- +xref: UM-BBD_enzymeID:e0442 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018848 +name: pinocarveol isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_enzymeID:e0447] +xref: EC:5.5.1.- +xref: UM-BBD_enzymeID:e0447 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018849 +name: muconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1] +subset: gosubset_prok +synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1] +synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1] +synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1] +synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1] +synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1] +synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1] +synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1] +xref: EC:5.5.1.1 +xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN +xref: UM-BBD_enzymeID:e0133 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018850 +name: chloromuconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7] +subset: gosubset_prok +synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7] +synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7] +xref: EC:5.5.1.7 +xref: MetaCyc:CHLOROMUCONATE-CYCLOISOMERASE-RXN +xref: UM-BBD_enzymeID:e0065 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018851 +name: alpha-pinene-oxide decyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10] +synonym: "alpha-pinene oxide lyase activity" EXACT [] +synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10] +xref: EC:5.5.1.10 +xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN +xref: UM-BBD_enzymeID:e0471 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018852 +name: dichloromuconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11] +synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11] +xref: EC:5.5.1.11 +xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN +xref: UM-BBD_enzymeID:e0132 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018853 +name: perillyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_enzymeID:e0460] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0460 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018854 +name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_enzymeID:e0465] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0465 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018855 +name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_enzymeID:e0303] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0303 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018856 +name: benzoyl acetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl acetate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_enzymeID:e0212] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0212 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018857 +name: 2,4-dichlorobenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_enzymeID:e0110] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0110 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018858 +name: benzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA. Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates." [EC:6.2.1.25] +subset: gosubset_prok +synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25] +synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25] +synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25] +synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25] +xref: EC:6.2.1.25 +xref: MetaCyc:BENZOATE--COA-LIGASE-RXN +xref: UM-BBD_enzymeID:e0131 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018859 +name: 4-hydroxybenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27] +subset: gosubset_prok +synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27] +synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27] +synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27] +synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27] +synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27] +xref: EC:6.2.1.27 +xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN +xref: UM-BBD_enzymeID:e0130 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018860 +name: anthranilate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32] +subset: gosubset_prok +synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32] +synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32] +synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32] +synonym: "anthranilate--CoA ligase activity" EXACT [] +synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32] +synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32] +xref: EC:6.2.1.32 +xref: MetaCyc:AMINOBENZCOALIG-RXN +xref: UM-BBD_enzymeID:e0129 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018861 +name: 4-chlorobenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. Requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33] +subset: gosubset_prok +synonym: "4-chlorobenzoate:CoA ligase activity" EXACT [] +xref: EC:6.2.1.33 +xref: MetaCyc:6.2.1.33-RXN +xref: UM-BBD_enzymeID:e0112 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018862 +name: phenylphosphate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_enzymeID:e0158] +xref: EC:6.4.1.- +xref: UM-BBD_enzymeID:e0158 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0018863 +name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0335] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0335 +is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity + +[Term] +id: GO:0018864 +name: acetylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "acetylene metabolism" EXACT [] +synonym: "ethyne metabolic process" EXACT [] +synonym: "ethyne metabolism" EXACT [] +xref: UM-BBD_pathwayID:atl +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043452 ! cellular alkyne metabolic process + +[Term] +id: GO:0018865 +name: acrylonitrile metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm] +subset: gosubset_prok +synonym: "acrylonitrile metabolism" EXACT [] +xref: UM-BBD_pathwayID:acr +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0018866 +name: adamantanone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] +subset: gosubset_prok +synonym: "adamantanone metabolism" EXACT [] +xref: UM-BBD_pathwayID:ada +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0018867 +name: alpha-pinene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [http://umbbd.ahc.umn.edu/apn/apn_map.html, UM-BBD_pathwayID:apn] +subset: gosubset_prok +synonym: "alpha-pinene metabolism" EXACT [] +xref: UM-BBD_pathwayID:apn +is_a: GO:0043692 ! monoterpene metabolic process + +[Term] +id: GO:0018868 +name: 2-aminobenzenesulfonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [http://umbbd.ahc.umn.edu/abs/abs_map.html, UM-BBD_pathwayID:abs] +subset: gosubset_prok +synonym: "2-aminobenzenesulfonate metabolism" EXACT [] +synonym: "2-aminobenzenesulphonate metabolic process" EXACT [] +synonym: "2-aminobenzenesulphonate metabolism" EXACT [] +xref: UM-BBD_pathwayID:abs +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018870 +name: anaerobic 2-aminobenzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic 2-aminobenzoate metabolism" EXACT [] +xref: UM-BBD_pathwayID:abz +is_a: GO:0018875 ! anaerobic benzoate metabolic process +is_a: GO:0043420 ! anthranilate metabolic process + +[Term] +id: GO:0018871 +name: 1-aminocyclopropane-1-carboxylate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [http://umbbd.ahc.umn.edu/acp/acp_map.html, UM-BBD_pathwayID:acp] +subset: gosubset_prok +synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT [] +synonym: "ACP metabolic process" EXACT [] +synonym: "ACP metabolism" EXACT [] +xref: UM-BBD_pathwayID:acp +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0018872 +name: arsonoacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [http://umbbd.ahc.umn.edu/ara/ara_map.html, UM-BBD_pathwayID:ara] +subset: gosubset_prok +synonym: "arsonoacetate metabolism" EXACT [] +xref: UM-BBD_pathwayID:ara +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0018873 +name: atrazine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [http://umbbd.ahc.umn.edu/atr/atr_map.html, UM-BBD_pathwayID:atr] +subset: gosubset_prok +synonym: "atrazine metabolism" EXACT [] +xref: UM-BBD_pathwayID:atr +is_a: GO:0018965 ! s-triazine compound metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018874 +name: benzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "benzoate metabolism" EXACT [] +xref: MetaCyc:P321-PWY +xref: UM-BBD_pathwayID:benz2 +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018875 +name: anaerobic benzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic benzoate metabolism" EXACT [] +xref: MetaCyc:CENTBENZCOA-PWY +xref: UM-BBD_pathwayID:benz +is_a: GO:0018874 ! benzoate metabolic process + +[Term] +id: GO:0018876 +name: benzonitrile metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn] +subset: gosubset_prok +synonym: "benzonitrile metabolism" EXACT [] +xref: UM-BBD_pathwayID:bzn +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018877 +name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch] +subset: gosubset_prok +synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] +xref: UM-BBD_pathwayID:hch +is_a: GO:0019497 ! hexachlorocyclohexane metabolic process + +[Term] +id: GO:0018878 +name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] +is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process + +[Term] +id: GO:0018879 +name: biphenyl metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl] +subset: gosubset_prok +synonym: "biphenyl metabolism" EXACT [] +synonym: "xenene metabolic process" EXACT [] +synonym: "xenene metabolism" EXACT [] +xref: UM-BBD_pathwayID:bph +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018880 +name: 4-chlorobiphenyl metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl] +subset: gosubset_prok +synonym: "4-chlorobiphenyl metabolism" EXACT [] +xref: UM-BBD_pathwayID:cbp +is_a: GO:0018879 ! biphenyl metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018881 +name: bromoxynil metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai] +subset: gosubset_prok +synonym: "bromoxynil metabolism" EXACT [] +xref: UM-BBD_pathwayID:box +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018882 +name: (+)-camphor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [http://umbbd.ahc.umn.edu/cam/cam_map.html, UM-BBD_pathwayID:cam] +subset: gosubset_prok +synonym: "(+)-camphor metabolism" EXACT [] +synonym: "camphor metabolic process" EXACT [] +synonym: "camphor metabolism" EXACT [] +xref: UM-BBD_pathwayID:cam +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0043692 ! monoterpene metabolic process + +[Term] +id: GO:0018883 +name: caprolactam metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "caprolactam metabolism" EXACT [] +xref: UM-BBD_pathwayID:cap +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018884 +name: carbazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl] +subset: gosubset_prok +synonym: "CAR metabolic process" EXACT [] +synonym: "CAR metabolism" EXACT [] +synonym: "carbazole metabolism" EXACT [] +xref: UM-BBD_pathwayID:car +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018885 +name: carbon tetrachloride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [http://umbbd.ahc.umn.edu/ctc/ctc_map.html, UM-BBD_pathwayID:ctc] +subset: gosubset_prok +synonym: "carbon tetrachloride metabolism" EXACT [] +xref: Reactome:207153 +xref: Reactome:216726 +xref: Reactome:76434 +xref: UM-BBD_pathwayID:ctc +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018886 +name: anaerobic carbon tetrachloride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic carbon tetrachloride metabolism" EXACT [] +xref: UM-BBD_pathwayID:ctc +is_a: GO:0018885 ! carbon tetrachloride metabolic process + +[Term] +id: GO:0018887 +name: 4-carboxy-4'-sulfoazobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860] +subset: gosubset_prok +synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT [] +synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT [] +synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:csab +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018888 +name: 3-chloroacrylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai] +subset: gosubset_prok +synonym: "3-chloroacrylic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:caa +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018889 +name: 2-chloro-N-isopropylacetanilide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [http://umbbd.ahc.umn.edu/ppc/ppc_map.html, UM-BBD_pathwayID:ppc] +subset: gosubset_prok +synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT [] +synonym: "propachlor metabolic process" EXACT [] +synonym: "propachlor metabolism" EXACT [] +xref: UM-BBD_pathwayID:ppc +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018890 +name: cyanamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "cyanamide metabolism" EXACT [] +xref: UM-BBD_pathwayID:cnm +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018891 +name: cyclohexanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "cyclohexanol metabolism" EXACT [] +xref: UM-BBD_pathwayID:chx +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018892 +name: cyclohexylsulfamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs] +subset: gosubset_prok +synonym: "cyclohexylsulfamate metabolism" EXACT [] +synonym: "cyclohexylsulphamate metabolic process" EXACT [] +synonym: "cyclohexylsulphamate metabolism" EXACT [] +xref: UM-BBD_pathwayID:chs +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018893 +name: dibenzofuran metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf] +subset: gosubset_prok +synonym: "dibenzofuran metabolism" EXACT [] +xref: UM-BBD_pathwayID:dbf +is_a: GO:0018904 ! organic ether metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018894 +name: dibenzo-p-dioxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd] +subset: gosubset_prok +synonym: "dibenzo-p-dioxin metabolism" EXACT [] +synonym: "oxanthrene metabolic process" EXACT [] +synonym: "oxanthrene metabolism" EXACT [] +synonym: "phenodioxin metabolic process" EXACT [] +synonym: "phenodioxin metabolism" EXACT [] +xref: UM-BBD_pathwayID:dpd +is_a: GO:0018904 ! organic ether metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018895 +name: dibenzothiophene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483] +subset: gosubset_prok +synonym: "dibenzothiophene metabolism" EXACT [] +synonym: "diphenylene sulfide metabolic process" EXACT [] +synonym: "diphenylene sulfide metabolism" EXACT [] +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018896 +name: dibenzothiophene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] +subset: gosubset_prok +synonym: "dibenzothiophene breakdown" EXACT [] +synonym: "dibenzothiophene catabolism" EXACT [] +synonym: "dibenzothiophene degradation" EXACT [] +xref: UM-BBD_pathwayID:dbt2 +is_a: GO:0018895 ! dibenzothiophene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0018897 +name: dibenzothiophene desulfurization +namespace: biological_process +def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] +subset: gosubset_prok +synonym: "dibenzothiophene desulphurization" EXACT [] +xref: MetaCyc:PWY-681 +xref: UM-BBD_pathwayID:dbt +is_a: GO:0018895 ! dibenzothiophene metabolic process + +[Term] +id: GO:0018898 +name: 2,4-dichlorobenzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, http://umbbd.ahc.umn.edu/dcb/dcb_map.html, UM-BBD_pathwayID:dcb] +subset: gosubset_prok +synonym: "2,4-dichlorobenzoate metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcb +is_a: GO:0018874 ! benzoate metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018899 +name: 1,2-dichloroethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl] +subset: gosubset_prok +synonym: "1,2-dichloroethane metabolism" EXACT [] +xref: UM-BBD_pathwayID:dce +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018900 +name: dichloromethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm] +subset: gosubset_prok +synonym: "dichloromethane metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcm +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018901 +name: 2,4-dichlorophenoxyacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d] +subset: gosubset_prok +synonym: "2,4-D metabolic process" EXACT [] +synonym: "2,4-D metabolism" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:2\,4-d +is_a: GO:0018904 ! organic ether metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018902 +name: 1,3-dichloro-2-propanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, http://umbbd.ahc.umn.edu/dcp/dcp_map.html, UM-BBD_pathwayID:dcp] +subset: gosubset_prok +synonym: "1,3-dichloro-2-propanol metabolism" EXACT [] +synonym: "DCP metabolic process" EXACT [] +synonym: "DCP metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcp +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0018903 +name: 1,3-dichloropropene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [http://umbbd.ahc.umn.edu/cpr/cpr_map.html, UM-BBD_pathwayID:cpr] +subset: gosubset_prok +synonym: "1,3-dichloropropene metabolism" EXACT [] +synonym: "1,3-dichloropropylene metabolic process" EXACT [] +synonym: "1,3-dichloropropylene metabolism" EXACT [] +synonym: "gamma-chloroallylchloride metabolic process" EXACT [] +synonym: "gamma-chloroallylchloride metabolism" EXACT [] +xref: UM-BBD_pathwayID:cpr +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018904 +name: organic ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "organic ether metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018905 +name: dimethyl ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme] +subset: gosubset_prok +synonym: "dimethyl ether metabolism" EXACT [] +synonym: "methyl ether metabolic process" EXACT [] +synonym: "methyl ether metabolism" EXACT [] +xref: UM-BBD_pathwayID:dme +is_a: GO:0018904 ! organic ether metabolic process + +[Term] +id: GO:0018906 +name: methyl tert-butyl ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb] +subset: gosubset_prok +synonym: "methyl tert-butyl ether metabolism" EXACT [] +xref: UM-BBD_pathwayID:mtb +is_a: GO:0018904 ! organic ether metabolic process + +[Term] +id: GO:0018907 +name: dimethyl sulfoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "dimethyl sulfoxide metabolism" EXACT [] +synonym: "dimethyl sulphoxide metabolic process" EXACT [] +synonym: "dimethyl sulphoxide metabolism" EXACT [] +synonym: "DMSO metabolic process" EXACT [] +synonym: "DMSO metabolism" EXACT [] +xref: UM-BBD_pathwayID:sulf +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0018908 +name: organosulfide cycle +namespace: biological_process +subset: gosubset_prok +synonym: "organosulphide cycle" EXACT [] +xref: UM-BBD_pathwayID:sulf +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0018909 +name: dodecyl sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds] +subset: gosubset_prok +synonym: "dodecyl sulfate metabolism" EXACT [] +synonym: "dodecyl sulphate metabolic process" EXACT [] +synonym: "dodecyl sulphate metabolism" EXACT [] +xref: UM-BBD_pathwayID:dds +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018910 +name: benzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "benzene metabolism" EXACT [] +xref: Reactome:205893 +xref: Reactome:215449 +xref: Reactome:76416 +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018911 +name: 1,2,4-trichlorobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm] +subset: gosubset_prok +synonym: "1,2,4-trichlorobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tbz +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018912 +name: 1,4-dichlorobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm] +subset: gosubset_prok +synonym: "1,4-dichlorobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcz +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018913 +name: anaerobic ethylbenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic ethylbenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:ethb +is_a: GO:0018915 ! ethylbenzene metabolic process + +[Term] +id: GO:0018914 +name: chlorobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/] +subset: gosubset_prok +synonym: "chlorobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:cb +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018915 +name: ethylbenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm] +subset: gosubset_prok +synonym: "ethylbenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:ethb2 +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018916 +name: nitrobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "nitrobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:nb +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018917 +name: fluorene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [http://umbbd.ahc.umn.edu/flu/flu_map.html, UM-BBD_pathwayID:flu] +subset: gosubset_prok +synonym: "fluorene metabolism" EXACT [] +xref: UM-BBD_pathwayID:flu +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018918 +name: gallate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "gallate metabolism" EXACT [] +synonym: "gallic acid metabolic process" EXACT [] +synonym: "gallic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:gal +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0018919 +name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch] +subset: gosubset_prok +synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] +xref: MetaCyc:GAMMAHEXCHLORDEG-PWY +xref: UM-BBD_pathwayID:ghch +is_a: GO:0019497 ! hexachlorocyclohexane metabolic process + +[Term] +id: GO:0018920 +name: glyphosate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [http://umbbd.ahc.umn.edu/gly/gly_map.html, UM-BBD_pathwayID:gly] +subset: gosubset_prok +synonym: "glyphosate metabolism" EXACT [] +synonym: "Roundup metabolic process" EXACT [] +synonym: "Roundup metabolism" EXACT [] +xref: UM-BBD_pathwayID:gly +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0018921 +name: 3-hydroxybenzyl alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [http://umbbd.ahc.umn.edu/mcr/mcr_map.html, UM-BBD_pathwayID:mcr] +subset: gosubset_prok +synonym: "3-hydroxybenzyl alcohol metabolism" EXACT [] +xref: UM-BBD_pathwayID:mcr +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0018922 +name: iprodione metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [http://umbbd.ahc.umn.edu/ipd/ipd_map.html, UM-BBD_pathwayID:ipd] +subset: gosubset_prok +synonym: "iprodione metabolism" EXACT [] +xref: UM-BBD_pathwayID:ipd +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018923 +name: limonene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [http://umbbd.ahc.umn.edu/lim/lim_map.html, UM-BBD_pathwayID:lim] +subset: gosubset_prok +synonym: "limonene metabolism" EXACT [] +xref: UM-BBD_pathwayID:lim +is_a: GO:0043692 ! monoterpene metabolic process + +[Term] +id: GO:0018924 +name: mandelate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl] +subset: gosubset_prok +synonym: "mandelate metabolism" EXACT [] +synonym: "mandelic acid metabolic process" EXACT [] +synonym: "mandelic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:mca +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0018925 +name: m-cresol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl] +subset: gosubset_prok +synonym: "3-hydroxytoluene metabolic process" EXACT [] +synonym: "3-hydroxytoluene metabolism" EXACT [] +synonym: "m-cresol metabolism" EXACT [] +synonym: "meta-cresol metabolic process" EXACT [] +synonym: "meta-cresol metabolism" EXACT [] +xref: MetaCyc:M-CRESOL-DEGRADATION-PWY +xref: UM-BBD_pathwayID:mcr +is_a: GO:0042212 ! cresol metabolic process + +[Term] +id: GO:0018926 +name: methanesulfonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa] +subset: gosubset_prok +synonym: "methanesulfonic acid metabolism" EXACT [] +synonym: "methanesulphonic acid metabolic process" EXACT [] +synonym: "methanesulphonic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:msa +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018927 +name: methionine and threonine metabolic process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule. +is_obsolete: true +consider: GO:0006555 +consider: GO:0006566 + +[Term] +id: GO:0018928 +name: methyl ethyl ketone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [http://umbbd.ahc.umn.edu/mek/mek_map.html, UM-BBD_pathwayID:mek] +subset: gosubset_prok +synonym: "2-butanone metabolic process" EXACT [] +synonym: "2-butanone metabolism" EXACT [] +synonym: "MEK metabolic process" EXACT [] +synonym: "MEK metabolism" EXACT [] +synonym: "methyl ethyl ketone metabolism" EXACT [] +xref: UM-BBD_pathwayID:mek +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0018929 +name: methyl fluoride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf] +subset: gosubset_prok +synonym: "methyl fluoride metabolism" EXACT [] +xref: UM-BBD_pathwayID:mf +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018930 +name: 3-methylquinoline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] +subset: gosubset_prok +synonym: "3-methylquinoline metabolism" EXACT [] +xref: UM-BBD_pathwayID:mqn +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018931 +name: naphthalene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm] +subset: gosubset_prok +synonym: "naphthalene metabolism" EXACT [] +xref: UM-BBD_pathwayID:naph +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018933 +name: nicotine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] +subset: gosubset_prok +synonym: "nicotine metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0018934 +name: nitrilotriacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta] +subset: gosubset_prok +synonym: "nitrilotriacetate metabolism" EXACT [] +xref: UM-BBD_pathwayID:nta +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0018935 +name: aerobic nitrilotriacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "aerobic nitrilotriacetate metabolism" EXACT [] +is_a: GO:0018934 ! nitrilotriacetate metabolic process + +[Term] +id: GO:0018936 +name: anaerobic nitrilotriacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic nitrilotriacetate metabolism" EXACT [] +is_a: GO:0018934 ! nitrilotriacetate metabolic process + +[Term] +id: GO:0018937 +name: nitroglycerin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [http://umbbd.ahc.umn.edu/ng/ng_map.html, UM-BBD_pathwayID:ng] +subset: gosubset_prok +synonym: "NG metabolic process" EXACT [] +synonym: "NG metabolism" EXACT [] +synonym: "nitroglycerin metabolism" EXACT [] +xref: MetaCyc:P201-PWY +xref: UM-BBD_pathwayID:ng +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018938 +name: 2-nitropropane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [http://umbbd.ahc.umn.edu/npp/npp_map.html, UM-BBD_pathwayID:npp] +subset: gosubset_prok +synonym: "2-nitropropane metabolism" EXACT [] +xref: MetaCyc:PWY-723 +xref: UM-BBD_pathwayID:npp +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:0018939 +name: n-octane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct] +subset: gosubset_prok +synonym: "n-octane metabolism" EXACT [] +xref: UM-BBD_pathwayID:oct +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:0018940 +name: orcinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl] +subset: gosubset_prok +synonym: "orcin metabolic process" EXACT [] +synonym: "orcin metabolism" EXACT [] +synonym: "orcinol metabolism" EXACT [] +xref: MetaCyc:P342-PWY +xref: UM-BBD_pathwayID:orc +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0018941 +name: organomercury metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "organomercury metabolism" EXACT [] +xref: UM-BBD_pathwayID:ogm +is_a: GO:0018942 ! organometal metabolic process + +[Term] +id: GO:0018942 +name: organometal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "organometal metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0018943 +name: organotin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "organotin metabolism" EXACT [] +is_a: GO:0018942 ! organometal metabolic process + +[Term] +id: GO:0018944 +name: tri-n-butyltin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt] +subset: gosubset_prok +synonym: "tri-n-butyltin metabolism" EXACT [] +xref: UM-BBD_pathwayID:tbt +is_a: GO:0018943 ! organotin metabolic process + +[Term] +id: GO:0018945 +name: organosilicon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl] +subset: gosubset_prok +synonym: "organosilicon metabolism" EXACT [] +synonym: "organosilicone metabolic process" EXACT [] +synonym: "organosilicone metabolism" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018946 +name: aerobic organosilicon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "aerobic organosilicon metabolism" EXACT [] +synonym: "aerobic organosilicone metabolic process" EXACT [] +synonym: "aerobic organosilicone metabolism" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0018945 ! organosilicon metabolic process + +[Term] +id: GO:0018947 +name: anaerobic organosilicon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "anaerobic organosilicon metabolism" EXACT [] +synonym: "anaerobic organosilicone metabolic process" EXACT [] +synonym: "anaerobic organosilicone metabolism" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0018945 ! organosilicon metabolic process + +[Term] +id: GO:0018948 +name: xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl] +subset: gosubset_prok +synonym: "xylene metabolism" EXACT [] +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018949 +name: m-xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +subset: gosubset_prok +synonym: "m-xylene metabolism" EXACT [] +synonym: "meta-xylene metabolic process" EXACT [] +synonym: "meta-xylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:mxy +is_a: GO:0018948 ! xylene metabolic process + +[Term] +id: GO:0018950 +name: o-xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +subset: gosubset_prok +synonym: "o-xylene metabolism" EXACT [] +synonym: "ortho-xylene metabolic process" EXACT [] +synonym: "ortho-xylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:oxy +is_a: GO:0018948 ! xylene metabolic process + +[Term] +id: GO:0018951 +name: p-xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +subset: gosubset_prok +synonym: "p-xylene metabolism" EXACT [] +synonym: "para-xylene metabolic process" EXACT [] +synonym: "para-xylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pxy +is_a: GO:0018948 ! xylene metabolic process + +[Term] +id: GO:0018952 +name: parathion metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, a caricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [http://umbbd.ahc.umn.edu/pthn/pthn_map.html, UM-BBD_pathwayID:pthn] +subset: gosubset_prok +synonym: "parathion metabolism" EXACT [] +xref: UM-BBD_pathwayID:pthn +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018953 +name: p-cymene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy] +subset: gosubset_prok +synonym: "p-cymene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pcy +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0018954 +name: pentaerythritol tetranitrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn] +subset: gosubset_prok +synonym: "pentaerythritol tetranitrate metabolism" EXACT [] +xref: UM-BBD_pathwayID:petn +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018955 +name: phenanthrene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, http://umbbd.ahc.umn.edu/pha/pha_map.html, UM-BBD_pathwayID:pha] +subset: gosubset_prok +synonym: "phenanthrene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pha +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018956 +name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [http://umbbd.ahc.umn.edu/pha3/pha3_map.html, UM-BBD_pathwayID:pha3] +subset: gosubset_prok +synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] +synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] +xref: UM-BBD_pathwayID:pha3 +is_a: GO:0042216 ! phenanthrene catabolic process + +[Term] +id: GO:0018957 +name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [http://umbbd.ahc.umn.edu/pha2/pha2_map.html, UM-BBD_pathwayID:pha2] +subset: gosubset_prok +synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] +synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] +xref: UM-BBD_pathwayID:pha2 +is_a: GO:0042216 ! phenanthrene catabolic process + +[Term] +id: GO:0018958 +name: phenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. +subset: gosubset_prok +synonym: "carbolic acid metabolic process" EXACT [] +synonym: "carbolic acid metabolism" EXACT [] +synonym: "hydroxybenzene metabolic process" EXACT [] +synonym: "hydroxybenzene metabolism" EXACT [] +synonym: "phenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process + +[Term] +id: GO:0018959 +name: aerobic phenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aerobic carbolic acid metabolic process" EXACT [] +synonym: "aerobic carbolic acid metabolism" EXACT [] +synonym: "aerobic hydroxybenzene metabolic process" EXACT [] +synonym: "aerobic hydroxybenzene metabolism" EXACT [] +synonym: "aerobic phenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0018960 +name: 4-nitrophenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl] +subset: gosubset_prok +synonym: "4-nitrophenol metabolism" EXACT [] +synonym: "p-nitrophenol metabolic process" EXACT [] +synonym: "p-nitrophenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:nphe +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018961 +name: pentachlorophenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [http://umbbd.ahc.umn.edu/pcp/pcp_map.html, UM-BBD_pathwayID:pcp] +subset: gosubset_prok +synonym: "PCP metabolic process" EXACT [] +synonym: "PCP metabolism" EXACT [] +synonym: "pentachlorophenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:pcp +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018962 +name: 3-phenylpropionate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa] +subset: gosubset_prok +synonym: "3-phenylpropionate metabolism" EXACT [] +synonym: "hydrocinnamic acid metabolic process" EXACT [] +synonym: "hydrocinnamic acid metabolism" EXACT [] +synonym: "phenylpropanoate metabolic process" EXACT [] +synonym: "phenylpropanoate metabolism" EXACT [] +xref: UM-BBD_pathwayID:ppa +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018963 +name: phthalate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [http://umbbd.ahc.umn.edu/pth/pth_map.html, UM-BBD_pathwayID:pth] +subset: gosubset_prok +synonym: "phthalate metabolism" EXACT [] +synonym: "phthalic acid metabolic process" EXACT [] +synonym: "phthalic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:pth +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0018964 +name: propylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl] +subset: gosubset_prok +synonym: "propylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pro +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018965 +name: s-triazine compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [http://umbbd.ahc.umn.edu/tria/tria_map.html, UM-BBD_pathwayID:tria] +subset: gosubset_prok +synonym: "s-triazine compound metabolism" EXACT [] +xref: UM-BBD_pathwayID:tria +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018966 +name: styrene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, http://umbbd.ahc.umn.edu/sty/sty_map.html, UM-BBD_pathwayID:sty] +subset: gosubset_prok +synonym: "styrene metabolism" EXACT [] +xref: UM-BBD_pathwayID:sty +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018967 +name: tetrachloroethylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm] +subset: gosubset_prok +synonym: "tetrachloroethene metabolic process" EXACT [] +synonym: "tetrachloroethene metabolism" EXACT [] +synonym: "tetrachloroethylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tce2 +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018968 +name: tetrahydrofuran metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf] +subset: gosubset_prok +synonym: "tetrahydrofuran metabolism" EXACT [] +synonym: "THF metabolic process" EXACT [] +synonym: "THF metabolism" EXACT [] +xref: UM-BBD_pathwayID:thf +is_a: GO:0018904 ! organic ether metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018969 +name: thiocyanate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl] +subset: gosubset_prok +synonym: "thiocyanate metabolism" EXACT [] +synonym: "thiocyanic acid metabolic process" EXACT [] +synonym: "thiocyanic acid metabolism" EXACT [] +xref: MetaCyc:P581-PWY +xref: UM-BBD_pathwayID:thc +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018970 +name: toluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [http://umbbd.ahc.umn.edu/tol/tol_map.html, UM-BBD_pathwayID:tol] +subset: gosubset_prok +synonym: "methylbenzene metabolic process" EXACT [] +synonym: "methylbenzene metabolism" EXACT [] +synonym: "toluene metabolism" EXACT [] +is_a: GO:0042537 ! benzene and derivative metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018971 +name: anaerobic toluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic toluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tol2 +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0018972 +name: toluene-4-sulfonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai] +subset: gosubset_prok +synonym: "4-methylbenzenesulfonate metabolic process" EXACT [] +synonym: "4-methylbenzenesulfonate metabolism" EXACT [] +synonym: "4-toluenesulfonate metabolic process" EXACT [] +synonym: "4-toluenesulfonate metabolism" EXACT [] +synonym: "toluene-4-sulfonate metabolism" EXACT [] +synonym: "toluene-4-sulphonate metabolic process" EXACT [] +synonym: "toluene-4-sulphonate metabolism" EXACT [] +xref: MetaCyc:TOLSULFDEG-PWY +xref: UM-BBD_pathwayID:tsa +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0018973 +name: trinitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] +subset: gosubset_prok +synonym: "trinitrotoluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tnt +is_a: GO:0019326 ! nitrotoluene metabolic process + +[Term] +id: GO:0018974 +name: 2,4,6-trinitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767] +subset: gosubset_prok +synonym: "2,4,6-trinitrotoluene metabolism" EXACT [] +synonym: "TNT metabolic process" EXACT [] +synonym: "TNT metabolism" EXACT [] +is_a: GO:0018973 ! trinitrotoluene metabolic process + +[Term] +id: GO:0018975 +name: anaerobic 2,4,6-trinitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tnt2 +is_a: GO:0018971 ! anaerobic toluene metabolic process +is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process + +[Term] +id: GO:0018976 +name: 1,2,3-tribromopropane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl] +subset: gosubset_prok +synonym: "1,2,3-tribromopropane metabolism" EXACT [] +xref: UM-BBD_pathwayID:tbp +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018977 +name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] +subset: gosubset_prok +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] +synonym: "DDT metabolic process" EXACT [] +synonym: "DDT metabolism" EXACT [] +xref: UM-BBD_pathwayID:ddt +is_a: GO:0017143 ! insecticide metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process +relationship: part_of GO:0046680 ! response to DDT + +[Term] +id: GO:0018978 +name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] +synonym: "anaerobic DDT metabolic process" EXACT [] +synonym: "anaerobic DDT metabolism" EXACT [] +xref: UM-BBD_pathwayID:ddt2 +is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process + +[Term] +id: GO:0018979 +name: trichloroethylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl] +subset: gosubset_prok +synonym: "TCE metabolic process" EXACT [] +synonym: "TCE metabolism" EXACT [] +synonym: "trichloroethene metabolic process" EXACT [] +synonym: "trichloroethene metabolism" EXACT [] +synonym: "trichloroethylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tce +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018980 +name: 2,4,5-trichlorophenoxyacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t] +subset: gosubset_prok +synonym: "2,4,5-T metabolic process" EXACT [] +synonym: "2,4,5-T metabolism" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:2\,4\,5-t +is_a: GO:0018904 ! organic ether metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0018981 +name: triethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl] +subset: gosubset_prok +synonym: "triethanolamine metabolism" EXACT [] +xref: UM-BBD_pathwayID:tea +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0042439 ! ethanolamine and derivative metabolic process + +[Term] +id: GO:0018982 +name: vanillin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl] +subset: gosubset_prok +synonym: "vanillic aldehyde metabolic process" EXACT [] +synonym: "vanillic aldehyde metabolism" EXACT [] +synonym: "vanillin metabolism" EXACT [] +xref: UM-BBD_pathwayID:van +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process + +[Term] +id: GO:0018983 +name: Z-phenylacetaldoxime metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [http://umbbd.ahc.umn.edu/car/car_map.html, UM-BBD_pathwayID:car] +subset: gosubset_prok +synonym: "Z-phenylacetaldoxime metabolism" EXACT [] +xref: UM-BBD_pathwayID:pao +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0018984 +name: naphthalenesulfonate metabolic process +namespace: biological_process +alt_id: GO:0018932 +def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai] +subset: gosubset_prok +synonym: "naphthalenesulfonate metabolism" EXACT [] +synonym: "naphthalenesulphonate metabolic process" EXACT [] +synonym: "naphthalenesulphonate metabolism" EXACT [] +xref: UM-BBD_pathwayID:nphs +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0018931 ! naphthalene metabolic process + +[Term] +id: GO:0018985 +name: pronuclear envelope synthesis +namespace: biological_process +def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems] +is_a: GO:0006998 ! nuclear envelope organization +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0018988 +name: molting cycle, protein-based cuticle +namespace: biological_process +def: "The periodic shedding of part or all of a cuticle, which is then replaced by a new cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu] +synonym: "molting cycle (sensu Protostomia and Nematoda)" EXACT [] +is_a: GO:0042303 ! molting cycle + +[Term] +id: GO:0018989 +name: apolysis +namespace: biological_process +def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0018990 +name: ecdysis, chitin-based cuticle +namespace: biological_process +def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle." [GOC:bf, GOC:mtg_sensu] +synonym: "ecdysis (sensu Insecta)" EXACT [] +is_a: GO:0042394 ! ecdysis, protein-based cuticle +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0018991 +name: oviposition +namespace: biological_process +def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] +synonym: "egg laying" BROAD [] +is_a: GO:0033057 ! reproductive behavior in a multicellular organism + +[Term] +id: GO:0018992 +name: germ-line sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0018993 +name: somatic sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0018995 +name: host +namespace: cellular_component +def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "host organism" EXACT [] +is_a: GO:0043245 ! extraorganismal space + +[Term] +id: GO:0018996 +name: molting cycle, collagen and cuticulin-based cuticle +namespace: biological_process +def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle." [GOC:jl, GOC:mtg_sensu] +synonym: "molting cycle (sensu Nematoda)" EXACT [] +is_a: GO:0018988 ! molting cycle, protein-based cuticle + +[Term] +id: GO:0018997 +name: electron transfer carrier +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the parent terms cover its function. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0018998 +name: metaxin +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +is_obsolete: true +consider: GO:0005741 + +[Term] +id: GO:0019000 +name: endonuclease G activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0004520 +consider: GO:0004521 + +[Term] +id: GO:0019001 +name: guanyl nucleotide binding +namespace: molecular_function +def: "Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: Reactome:6405 +is_a: GO:0017076 ! purine nucleotide binding + +[Term] +id: GO:0019002 +name: GMP binding +namespace: molecular_function +def: "Interacting selectively with GMP, guanosine monophosphate." [GOC:ai] +is_a: GO:0032561 ! guanyl ribonucleotide binding + +[Term] +id: GO:0019003 +name: GDP binding +namespace: molecular_function +def: "Interacting selectively with GDP, guanosine 5'-diphosphate." [GOC:ai] +is_a: GO:0032561 ! guanyl ribonucleotide binding + +[Term] +id: GO:0019005 +name: SCF ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] +synonym: "CDL1 complex" EXACT [] +synonym: "CRL1 complex" EXACT [] +synonym: "Cul1-RING ubiquitin ligase complex" EXACT [] +synonym: "cullin-RING ligase 1" EXACT [] +synonym: "SCF complex" EXACT [] +synonym: "SCF complex substrate recognition subunit" NARROW [] +synonym: "Skp1/Cul1/F-box protein complex" EXACT [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0019007 +name: N-acetylneuraminic acid phosphate synthase activity +namespace: molecular_function +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0019008 +name: molybdopterin synthase complex +namespace: cellular_component +alt_id: GO:0019009 +def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] +subset: gosubset_prok +synonym: "molybdopterin converting factor complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0019010 +name: farnesoic acid O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] +synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT [] +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0019011 +name: DNA replication accessory factor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +is_obsolete: true +consider: GO:0006260 + +[Term] +id: GO:0019012 +name: virion +namespace: cellular_component +def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] +subset: goslim_pir +synonym: "complete virus particle" EXACT [] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0019013 +name: viral nucleocapsid +namespace: cellular_component +alt_id: GO:0019014 +def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] +synonym: "core" BROAD [] +synonym: "nucleocapsid" EXACT [] +is_a: GO:0044423 ! virion part +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0019015 +name: viral genome +namespace: cellular_component +def: "The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0044423 ! virion part + +[Term] +id: GO:0019016 +name: non-segmented viral genome +namespace: cellular_component +def: "A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk] +is_a: GO:0019015 ! viral genome + +[Term] +id: GO:0019017 +name: segmented viral genome +namespace: cellular_component +def: "A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336] +is_a: GO:0019015 ! viral genome + +[Term] +id: GO:0019018 +name: bipartite viral genome +namespace: cellular_component +def: "A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] +is_a: GO:0019017 ! segmented viral genome + +[Term] +id: GO:0019019 +name: tripartite viral genome +namespace: cellular_component +def: "A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] +is_a: GO:0019017 ! segmented viral genome + +[Term] +id: GO:0019020 +name: multipartite viral genome +namespace: cellular_component +def: "A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] +is_a: GO:0019017 ! segmented viral genome + +[Term] +id: GO:0019021 +name: DNA viral genome +namespace: cellular_component +def: "A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336] +is_a: GO:0019015 ! viral genome + +[Term] +id: GO:0019022 +name: RNA viral genome +namespace: cellular_component +def: "A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336] +is_a: GO:0019015 ! viral genome + +[Term] +id: GO:0019023 +name: dsRNA viral genome +namespace: cellular_component +def: "A viral genome composed of double stranded RNA." [ISBN:0121585336] +is_a: GO:0019022 ! RNA viral genome + +[Term] +id: GO:0019024 +name: ssRNA viral genome +namespace: cellular_component +def: "A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336] +is_a: GO:0019022 ! RNA viral genome + +[Term] +id: GO:0019025 +name: positive sense viral genome +namespace: cellular_component +def: "A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336] +is_a: GO:0019024 ! ssRNA viral genome + +[Term] +id: GO:0019026 +name: negative sense viral genome +namespace: cellular_component +def: "A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336] +is_a: GO:0019024 ! ssRNA viral genome + +[Term] +id: GO:0019027 +name: ambisense viral genome +namespace: cellular_component +def: "A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336] +is_a: GO:0019024 ! ssRNA viral genome + +[Term] +id: GO:0019028 +name: viral capsid +namespace: cellular_component +alt_id: GO:0046728 +def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "viral capsid (sensu Retroviridae)" EXACT [] +is_a: GO:0044423 ! virion part + +[Term] +id: GO:0019029 +name: helical viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X] +is_a: GO:0019028 ! viral capsid + +[Term] +id: GO:0019030 +name: icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:071673706X] +synonym: "quasispherical viral capsid" EXACT [] +is_a: GO:0019028 ! viral capsid + +[Term] +id: GO:0019031 +name: viral envelope +namespace: cellular_component +def: "The lipid bilayer and associated glycoproteins that surround many types of virus particle." [ISBN:0781718325] +synonym: "viral glycoprotein" RELATED [] +synonym: "viral membrane" EXACT [] +is_a: GO:0044423 ! virion part + +[Term] +id: GO:0019032 +name: viral glycoprotein +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a type of gene product and not a location or complex. +is_obsolete: true +consider: GO:0019031 + +[Term] +id: GO:0019033 +name: viral tegument +namespace: cellular_component +def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0044423 ! virion part + +[Term] +id: GO:0019034 +name: viral replication complex +namespace: cellular_component +def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0019035 +name: viral integration complex +namespace: cellular_component +def: "Virus-specific complex of protein required for integrating viral genomes into the host genome." [ISBN:0781718325] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0019036 +name: viral transcriptional complex +namespace: cellular_component +def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0019037 +name: viral assembly intermediate +namespace: cellular_component +def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0019038 +name: provirus +namespace: cellular_component +def: "The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336] +is_a: GO:0019015 ! viral genome +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0019039 +name: viral-cell fusion molecule activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0019064 +consider: GO:0050839 + +[Term] +id: GO:0019040 +name: viral host shutoff protein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0004534 +consider: GO:0019057 + +[Term] +id: GO:0019041 +name: viral antireceptor activity +namespace: molecular_function +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0019042 +name: latent virus infection +namespace: biological_process +def: "A viral process characterized by (a) the lack of efficient expression of all the viral genes that are transcribed during productive infection, and (b) the activation of a unique latent transcriptional progam." [ISBN:0781702534] +is_a: GO:0022415 ! viral reproductive process + +[Term] +id: GO:0019043 +name: establishment of viral latency +namespace: biological_process +def: "The process by which a virus reaches a latent state." [ISBN:0781702534] +synonym: "lysogenic commitment" EXACT [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019042 ! latent virus infection + +[Term] +id: GO:0019044 +name: latent virus maintenance +namespace: biological_process +def: "Any process required for maintaining the latent form of the viral genome within a cell." [ISBN:0781718325] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019042 ! latent virus infection + +[Term] +id: GO:0019045 +name: latent virus replication +namespace: biological_process +def: "Any process required for latent viral replication in a cell." [ISBN:0781702534] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019042 ! latent virus infection + +[Term] +id: GO:0019046 +name: reactivation of latent virus +namespace: biological_process +def: "The reactivation of a virus from a latent to a lytic state." [ISBN:0781702534] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019042 ! latent virus infection + +[Term] +id: GO:0019047 +name: provirus integration +namespace: biological_process +def: "The molecular events that lead to the integration of a viral genome into the host genome." [ISBN:0121585336] +synonym: "prophage integration" EXACT [] +xref: Reactome:162592 +xref: Reactome:175567 +is_a: GO:0006310 ! DNA recombination +is_a: GO:0015074 ! DNA integration +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0030069 ! lysogeny + +[Term] +id: GO:0019048 +name: virus-host interaction +namespace: biological_process +def: "Interactions, directly with the host cell macromolecular machinery, to allow virus replication." [ISBN:0781718325] +synonym: "viral interaction with host" EXACT [] +xref: Reactome:168253 +is_a: GO:0022415 ! viral reproductive process +is_a: GO:0051701 ! interaction with host + +[Term] +id: GO:0019049 +name: evasion of host defenses by virus +namespace: biological_process +def: "Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272] +synonym: "viral host defence evasion" EXACT [] +synonym: "viral host defense evasion" EXACT [] +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0044415 ! evasion or tolerance of host defenses + +[Term] +id: GO:0019050 +name: suppression by virus of host apoptosis +namespace: biological_process +def: "Any viral process that results in the inhibition of apoptosis, facilitating prolonged cell survival during viral replication." [ISBN:0781718325] +synonym: "negative regulation by virus of host apoptosis" EXACT [] +synonym: "negative regulation of apoptosis by virus" EXACT [] +synonym: "suppression of apoptosis in host by virus" EXACT [] +is_a: GO:0019054 ! modification by virus of host cellular process +is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death + +[Term] +id: GO:0019051 +name: induction by virus of host apoptosis +namespace: biological_process +def: "The set of viral processes that result in the induction of apoptosis of infected cells, facilitating release and spread of progeny virions." [ISBN:0781718325] +synonym: "activation by virus of host apoptosis" EXACT [] +synonym: "activation by virus of host apoptotic programmed cell death" EXACT [] +synonym: "activation of apoptosis in host by virus" EXACT [] +synonym: "induction by virus of host apoptotic programmed cell death" EXACT [] +synonym: "induction of apoptosis in host by virus" EXACT [] +is_a: GO:0019054 ! modification by virus of host cellular process +is_a: GO:0052030 ! induction by symbiont of host apoptosis + +[Term] +id: GO:0019052 +name: suppression by virus of host intracellular antiviral response +namespace: biological_process +def: "Any viral process that results in the inhibition of intracellular (innate immune response) antiviral mechanisms, thereby facilitating viral replication." [GOC:pk] +synonym: "negative regulation by virus of intracellular antiviral response" EXACT [] +synonym: "negative regulation of host intracellular antiviral response by virus" EXACT [] +synonym: "suppression of host intracellular antiviral response by virus" EXACT [] +synonym: "viral inhibition of intracellular antiviral response" EXACT [] +is_a: GO:0019049 ! evasion of host defenses by virus +is_a: GO:0050687 ! negative regulation of defense response to virus +is_a: GO:0050690 ! regulation of defense response to virus by virus + +[Term] +id: GO:0019053 +name: suppression by virus of host extracellular antiviral response +namespace: biological_process +def: "Any viral process that results in the inhibition of extracellular (adaptive immune response) antiviral mechanisms, thereby facilitating viral replication." [GOC:pk] +synonym: "inhibition of extracellular antiviral response" EXACT [] +synonym: "negative regulation by virus of extracellular antiviral response" EXACT [] +synonym: "negative regulation of host extracellular antiviral response by virus" EXACT [] +synonym: "suppression of host extracellular antiviral response by virus" EXACT [] +is_a: GO:0019049 ! evasion of host defenses by virus +is_a: GO:0050687 ! negative regulation of defense response to virus +is_a: GO:0050690 ! regulation of defense response to virus by virus + +[Term] +id: GO:0019054 +name: modification by virus of host cellular process +namespace: biological_process +def: "The process in which a virus effects a change in the cellular pathways and activities of its host organism." [GOC:mah, GOC:pk] +synonym: "modulation by virus of host cellular process" EXACT [] +synonym: "modulation of cellular process in host by virus" RELATED [] +synonym: "regulation by virus of host cellular process" EXACT [] +synonym: "regulation of cellular process in host by virus" EXACT [] +synonym: "regulation of host cellular process by virus" EXACT [] +synonym: "viral host cell process manipulation" EXACT [] +xref: Reactome:168276 +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology + +[Term] +id: GO:0019055 +name: modification by virus of host cell cycle regulation +namespace: biological_process +def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325] +synonym: "viral perturbation of cell cycle regulation" EXACT [] +is_a: GO:0019054 ! modification by virus of host cellular process + +[Term] +id: GO:0019056 +name: modulation by virus of host transcription +namespace: biological_process +def: "The modulation by viral gene products of host RNA polymerase II facilitated transcription." [ISBN:0781718325] +synonym: "modification by virus of host transcription" EXACT [] +synonym: "viral perturbation of host cell transcription" EXACT [] +is_a: GO:0019054 ! modification by virus of host cellular process +is_a: GO:0052026 ! modulation by symbiont of host transcription + +[Term] +id: GO:0019057 +name: regulation of host mRNA translation by virus +namespace: biological_process +def: "Any process by which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325] +synonym: "host cell protein synthesis shutoff" BROAD [] +synonym: "host cell shutoff" BROAD [] +synonym: "modification by virus of host cell mRNA translation" EXACT [] +synonym: "regulation of host translation by virus" EXACT [] +synonym: "regulation of translation in host by virus" EXACT [] +synonym: "viral host shutoff protein" RELATED [] +synonym: "viral perturbation of host cell mRNA translation" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0019054 ! modification by virus of host cellular process + +[Term] +id: GO:0019058 +name: viral infectious cycle +namespace: biological_process +def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] +synonym: "lytic viral life cycle" NARROW [] +xref: Reactome:168254 +is_a: GO:0022415 ! viral reproductive process + +[Term] +id: GO:0019059 +name: initiation of viral infection +namespace: biological_process +def: "The set of processes involved in the start of virus infection of cells." [ISBN:0781702534] +xref: Reactome:162594 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019058 ! viral infectious cycle + +[Term] +id: GO:0019060 +name: intracellular transport of viral proteins in host cell +namespace: biological_process +def: "The directed movement of viral proteins within the host cell." [ISBN:0781702534] +synonym: "intracellular viral protein transport" EXACT [] +xref: Reactome:168869 +xref: Reactome:168871 +xref: Reactome:168874 +xref: Reactome:168884 +is_a: GO:0022415 ! viral reproductive process +is_a: GO:0030581 ! intracellular protein transport in host +relationship: part_of GO:0046719 ! regulation of viral protein levels in host cell + +[Term] +id: GO:0019061 +name: uncoating of virus +namespace: biological_process +def: "A general term applied to the events that occur after penetration; refers to the 'uncoating' of the viral genome from the nucleocapsid core." [ISBN:0781702534] +synonym: "viral uncoating" EXACT [] +xref: Reactome:162585 +xref: Reactome:168299 +xref: Reactome:168313 +xref: Reactome:168336 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019059 ! initiation of viral infection + +[Term] +id: GO:0019062 +name: virion attachment to host cell surface receptor +namespace: biological_process +def: "Any process involved in the specific binding of a viral antireceptor to a cell surface receptor." [ISBN:0781702534] +synonym: "virion attachment" EXACT [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0046718 ! entry of virus into host cell + +[Term] +id: GO:0019063 +name: virion penetration into host cell +namespace: biological_process +def: "Any process required for the introduction of virus particles into the cell." [ISBN:0781702534] +synonym: "virion penetration" EXACT [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0046718 ! entry of virus into host cell + +[Term] +id: GO:0019064 +name: viral envelope fusion with host membrane +namespace: biological_process +def: "A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane." [ISBN:0781702534] +synonym: "viral envelope fusion" BROAD [] +synonym: "viral envelope fusion with host cell membrane" EXACT [] +synonym: "viral envelope fusion with host plasma membrane" EXACT [] +synonym: "viral-cell fusion molecule activity" RELATED [] +xref: Reactome:164524 +xref: Reactome:168288 +xref: Reactome:168306 +xref: Reactome:168312 +is_a: GO:0006944 ! membrane fusion +is_a: GO:0019063 ! virion penetration into host cell + +[Term] +id: GO:0019065 +name: receptor mediated endocytosis of virus by host +namespace: biological_process +def: "Endocytosis of the virus particle resulting in the accumulation of virus particles within the cell via cytoplasmic vesicles." [ISBN:0781702534] +synonym: "receptor mediated endocytosis by host of virus particle" EXACT [] +synonym: "receptor mediated endocytosis of virus particle by host" EXACT [] +synonym: "viral receptor mediated endocytosis" EXACT [] +xref: Reactome:168275 +xref: Reactome:168285 +xref: Reactome:168287 +xref: Reactome:168292 +is_a: GO:0006898 ! receptor-mediated endocytosis +relationship: part_of GO:0019063 ! virion penetration into host cell + +[Term] +id: GO:0019066 +name: translocation of virus into host cell +namespace: biological_process +def: "The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534] +synonym: "viral translocation" EXACT [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019063 ! virion penetration into host cell + +[Term] +id: GO:0019067 +name: viral assembly, maturation, egress, and release +namespace: biological_process +def: "Any process involved in the assembly, maturation, egress, and release of progeny virions." [ISBN:1555811272] +xref: Reactome:168268 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019058 ! viral infectious cycle + +[Term] +id: GO:0019068 +name: virus assembly +namespace: biological_process +def: "A late phase of viral replication during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336] +synonym: "viral assembly" EXACT [] +synonym: "viral particle assembly" EXACT [] +synonym: "virus particle assembly" EXACT [] +xref: Reactome:168302 +xref: Reactome:168316 +xref: Reactome:168862 +xref: Reactome:168882 +xref: Reactome:168894 +is_a: GO:0022415 ! viral reproductive process +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0019069 +name: viral capsid assembly +namespace: biological_process +def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019068 ! virus assembly + +[Term] +id: GO:0019070 +name: viral genome maturation +namespace: biological_process +def: "Any viral process that occurs on newly synthesized viral genomes." [GOC:pk] +xref: Reactome:168330 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019068 ! virus assembly + +[Term] +id: GO:0019071 +name: viral DNA cleavage +namespace: biological_process +def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019070 ! viral genome maturation + +[Term] +id: GO:0019072 +name: viral genome packaging +namespace: biological_process +def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336] +xref: Reactome:168303 +xref: Reactome:168861 +xref: Reactome:168895 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019068 ! virus assembly + +[Term] +id: GO:0019073 +name: viral DNA genome packaging +namespace: biological_process +def: "The packing of viral DNA into a capsid." [ISBN:0781702534] +is_a: GO:0006323 ! DNA packaging +is_a: GO:0019072 ! viral genome packaging + +[Term] +id: GO:0019074 +name: viral RNA genome packaging +namespace: biological_process +def: "The packaging of viral RNA into a nucleocapsid." [ISBN:0781718325] +is_a: GO:0019072 ! viral genome packaging + +[Term] +id: GO:0019075 +name: virus maturation +namespace: biological_process +def: "The assembly of the component viral parts into an infectious virion." [ISBN:0781718325] +synonym: "viral maturation" EXACT [] +synonym: "viral particle maturation" EXACT [] +synonym: "virus particle maturation" RELATED [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0019076 +name: release of virus from host +namespace: biological_process +def: "The process by which a virus becomes free of a host cell either by the lysis of the host cell or by a non-lytic mechanism." [ISBN:0781702534] +synonym: "viral release" EXACT [] +xref: Reactome:168298 +xref: Reactome:168870 +xref: Reactome:168890 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0019077 +name: lytic viral release +namespace: biological_process +def: "A viral infection and replication that leads to the destruction (lysis) of the infected cell with the release of virions." [GOC:pk] +synonym: "lytic viral life cycle" NARROW [] +is_a: GO:0019076 ! release of virus from host + +[Term] +id: GO:0019078 +name: lytic viral budding +namespace: biological_process +def: "A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534] +is_a: GO:0019077 ! lytic viral release + +[Term] +id: GO:0019079 +name: viral genome replication +namespace: biological_process +def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] +synonym: "sigma virus replication" NARROW [] +synonym: "viral replication" BROAD [] +xref: Reactome:168282 +xref: Reactome:168307 +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019058 ! viral infectious cycle + +[Term] +id: GO:0019080 +name: viral genome expression +namespace: biological_process +def: "The achievement of highly specific, quantitative, temporal and spatial control of virus gene expression within the limited genetic resources of the viral genome." [ISBN:0121585336] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019058 ! viral infectious cycle + +[Term] +id: GO:0019081 +name: viral protein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of viral proteins." [ISBN:0781702534] +synonym: "viral protein anabolism" EXACT [] +synonym: "viral protein biosynthesis" EXACT [] +synonym: "viral protein formation" EXACT [] +synonym: "viral protein synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +relationship: part_of GO:0019080 ! viral genome expression + +[Term] +id: GO:0019082 +name: viral protein processing +namespace: biological_process +def: "The posttranslational processing of viral proteins." [ISBN:0781702534] +xref: Reactome:168858 +xref: Reactome:168875 +is_a: GO:0016485 ! protein processing +relationship: part_of GO:0019080 ! viral genome expression + +[Term] +id: GO:0019083 +name: viral transcription +namespace: biological_process +def: "The mechanisms involved in viral gene transcription, especially referring to those with temporal properties unique to viral transcription." [ISBN:0781702534] +xref: Reactome:167172 +xref: Reactome:168273 +xref: Reactome:168280 +xref: Reactome:168293 +xref: Reactome:168296 +xref: Reactome:168301 +xref: Reactome:168323 +xref: Reactome:168325 +xref: Reactome:168326 +xref: Reactome:168334 +is_a: GO:0009299 ! mRNA transcription +relationship: part_of GO:0019080 ! viral genome expression + +[Term] +id: GO:0019084 +name: (delayed) early viral mRNA transcription +namespace: biological_process +def: "The second round of viral gene transcription; most genes transcribed in this round are necessary for genome replication." [ISBN:0781702534] +synonym: "beta protein" RELATED [] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0019085 +name: immediate early viral mRNA transcription +namespace: biological_process +def: "The transcriptional period of the earliest expressed viral genes, mainly encoding transcriptional regulators." [ISBN:0781702534] +synonym: "alpha protein" BROAD [] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0019086 +name: late viral mRNA transcription +namespace: biological_process +def: "The last group of viral genes to be transcribed during the viral life cycle; genes consist mainly of those encoding structural proteins." [ISBN:0781702534] +synonym: "gamma protein" RELATED [] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0019087 +name: transformation of host cell by virus +namespace: biological_process +def: "Any virus-induced change in the morphological, biochemical, or growth parameters of a cell." [ISBN:0781702534] +synonym: "viral transformation" EXACT [] +synonym: "viral transformation of host cell" EXACT [] +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology + +[Term] +id: GO:0019088 +name: immortalization of host cell by virus +namespace: biological_process +def: "A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase." [ISBN:0781702534] +synonym: "viral immortalization" EXACT [] +is_a: GO:0019087 ! transformation of host cell by virus +is_a: GO:0020021 ! immortalization of host cell + +[Term] +id: GO:0019089 +name: transmission of virus +namespace: biological_process +def: "The transfer of virions in order to create new infection." [ISBN:0781702534] +synonym: "viral transmission" EXACT [] +is_a: GO:0022415 ! viral reproductive process +is_a: GO:0044007 ! dissemination or transmission of symbiont from host + +[Term] +id: GO:0019090 +name: mitochondrial rRNA export from mitochondrion +namespace: biological_process +def: "The directed movement of mitochondrial rRNA out of a mitochondrion." [GOC:ai] +synonym: "export of mitochondrial rRNA" BROAD [] +synonym: "mitochondrial rRNA export" EXACT [] +synonym: "mitochondrial rRNA export from mitochondria" EXACT [] +synonym: "mitochondrial rRNA export out of mitochondrion" EXACT [] +synonym: "mitochondrial rRNA transport from mitochondrion" EXACT [] +synonym: "mitochondrial rRNA, mitochondrial export" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0019093 ! mitochondrial RNA localization +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0019091 +name: mitochondrial lrRNA export from mitochondrion +namespace: biological_process +def: "The directed movement of mitochondrial lrRNA out of a mitochondrion." [GOC:ai] +synonym: "export of mitochondrial lrRNA" BROAD [] +synonym: "mitochondrial lrRNA export" EXACT [] +synonym: "mitochondrial lrRNA export from mitochondria" EXACT [] +synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT [] +synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT [] +synonym: "mitochondrial lrRNA, mitochondrial export" EXACT [] +is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion + +[Term] +id: GO:0019092 +name: mitochondrial srRNA export from mitochondrion +namespace: biological_process +def: "The directed movement of mitochondrial srRNA out of a mitochondrion." [GOC:ai] +synonym: "export of mitochondrial srRNA" BROAD [] +synonym: "mitochondrial srRNA export" EXACT [] +synonym: "mitochondrial srRNA export from mitochondria" EXACT [] +synonym: "mitochondrial srRNA export out of mitochondrion" EXACT [] +synonym: "mitochondrial srRNA transport from mitochondrion" EXACT [] +synonym: "mitochondrial srRNA, mitochondrial export" EXACT [] +is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion + +[Term] +id: GO:0019093 +name: mitochondrial RNA localization +namespace: biological_process +def: "Any process by which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] +synonym: "mtRNA localization" EXACT [] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:0019094 +name: pole plasm mRNA localization +namespace: biological_process +alt_id: GO:0048120 +def: "Any process by which mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:ai] +synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT [] +synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT [] +synonym: "oocyte pole plasm mRNA localization" EXACT [] +synonym: "pole granule RNA localization" BROAD [] +synonym: "pole granule RNA localization (sensu Insecta)" BROAD [] +synonym: "pole plasm mRNA localization (sensu Insecta)" EXACT [] +is_a: GO:0007316 ! pole plasm RNA localization +is_a: GO:0008298 ! intracellular mRNA localization + +[Term] +id: GO:0019095 +name: pole plasm mitochondrial rRNA localization +namespace: biological_process +alt_id: GO:0048117 +def: "Any process by which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm." [ISBN:0879694238] +synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT [] +synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT [] +synonym: "pole plasm mitochondrial rRNA localization (sensu Insecta)" EXACT [] +is_a: GO:0007316 ! pole plasm RNA localization +is_a: GO:0019093 ! mitochondrial RNA localization + +[Term] +id: GO:0019096 +name: pole plasm mitochondrial lrRNA localization +namespace: biological_process +alt_id: GO:0048118 +def: "Any process by which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm." [ISBN:0879694238] +synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT [] +synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT [] +synonym: "pole plasm mitochondrial lrRNA localization (sensu Insecta)" EXACT [] +is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization + +[Term] +id: GO:0019097 +name: pole plasm mitochondrial srRNA localization +namespace: biological_process +alt_id: GO:0048119 +def: "Any process by which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm." [ISBN:0879694238] +synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT [] +synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT [] +synonym: "pole plasm mitochondrial srRNA localization (sensu Insecta)" EXACT [] +is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization + +[Term] +id: GO:0019098 +name: reproductive behavior +namespace: biological_process +def: "The specific actions or reactions of an organism that are associated with reproduction." [GOC:jl] +synonym: "reproductive behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0022414 ! reproductive process + +[Term] +id: GO:0019099 +name: female germ-line sex determination +namespace: biological_process +alt_id: GO:0007544 +def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] +synonym: "sex determination, female germ-line determination" EXACT [] +is_a: GO:0007542 ! primary sex determination, germ-line +is_a: GO:0018992 ! germ-line sex determination +is_a: GO:0030237 ! female sex determination + +[Term] +id: GO:0019100 +name: male germ-line sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah] +is_a: GO:0007542 ! primary sex determination, germ-line +is_a: GO:0018992 ! germ-line sex determination +is_a: GO:0030238 ! male sex determination + +[Term] +id: GO:0019101 +name: female somatic sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] +is_a: GO:0018993 ! somatic sex determination +is_a: GO:0030237 ! female sex determination + +[Term] +id: GO:0019102 +name: male somatic sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] +is_a: GO:0018993 ! somatic sex determination +is_a: GO:0030238 ! male sex determination + +[Term] +id: GO:0019103 +name: pyrimidine nucleotide binding +namespace: molecular_function +def: "Interacting selectively with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0019104 +name: DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0008578 +def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] +comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. +subset: gosubset_prok +synonym: "DNA glycosylase activity" EXACT [] +synonym: "endonuclease VIII activity" RELATED [] +xref: EC:3.2.2.- +xref: Reactome:7370 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0019105 +name: N-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0016409 ! palmitoyltransferase activity +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0019107 +name: myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai] +xref: EC:2.3.1.- +xref: Reactome:2349 +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0019108 +name: aryl-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29] +synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29] +xref: EC:1.2.1.29 +xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0228 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019109 +name: acyl-CoA reductase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:1.3.99.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0019110 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors, hydrogen ions as acceptor +namespace: molecular_function +alt_id: GO:0016736 +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces hydrogen ions." [GOC:jl] +synonym: "oxidoreductase activity, acting on reduced ferredoxin as donor, hydrogen ions as acceptors" NARROW [] +xref: EC:1.18.3 +xref: EC:1.18.99 +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0019111 +name: phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-] +synonym: "phenanthrol sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0019112 +name: phenanthrol glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai] +xref: EC:2.4.1.- +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0019113 +name: limonene monooxygenase activity +namespace: molecular_function +xref: EC:1.14.13.- +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0019114 +name: catechol dioxygenase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:1.13.11.- +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0019115 +name: benzaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7] +subset: gosubset_prok +xref: EC:1.2.1.- +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019116 +name: hydroxy-nicotine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [GOC:jl, http://umbbd.ahc.umn.edu/] +subset: gosubset_prok +xref: EC:1.5.3.- +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0019117 +name: dihydroxyfluorene dioxygenase activity +namespace: molecular_function +xref: EC:1.13.11.- +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0019118 +name: phenanthrene-epoxide hydrolase activity +namespace: molecular_function +xref: EC:3.3.2.- +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0019119 +name: phenanthrene-9,10-epoxide hydrolase activity +namespace: molecular_function +xref: EC:3.3.2.- +is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity + +[Term] +id: GO:0019120 +name: hydrolase activity, acting on acid halide bonds, in C-halide compounds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:3.8.1 +is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds + +[Term] +id: GO:0019121 +name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine +namespace: biological_process +def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218] +subset: gosubset_prok +xref: RESID:AA0218 +is_a: GO:0018104 ! peptidoglycan-protein cross-linking +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0019122 +name: peptidyl-D-alanine racemization +namespace: biological_process +def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191] +comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'. +subset: gosubset_prok +synonym: "alanine racemization" BROAD [] +xref: RESID:AA0191 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0019123 +name: peptidyl-methionine racemization +namespace: biological_process +alt_id: GO:0018087 +alt_id: GO:0018369 +def: "The racemization of peptidyl-methionine." [RESID:AA0193] +subset: gosubset_prok +xref: RESID:AA0193 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019124 +name: peptidyl-isoleucine racemization +namespace: biological_process +alt_id: GO:0018088 +alt_id: GO:0018370 +def: "The racemization of peptidyl-isoleucine." [RESID:AA0192] +subset: gosubset_prok +xref: RESID:AA0192 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019125 +name: peptidyl-phenylalanine racemization +namespace: biological_process +alt_id: GO:0018089 +alt_id: GO:0018371 +def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194] +subset: gosubset_prok +xref: RESID:AA0194 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019126 +name: peptidyl-serine racemization +namespace: biological_process +alt_id: GO:0018090 +alt_id: GO:0018372 +def: "The racemization of peptidyl-serine." [RESID:AA0195] +subset: gosubset_prok +xref: RESID:AA0195 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019128 +name: peptidyl-tryptophan racemization +namespace: biological_process +alt_id: GO:0018092 +alt_id: GO:0018374 +def: "The racemization of peptidyl-tryptophan." [RESID:AA0198] +subset: gosubset_prok +xref: RESID:AA0198 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019129 +name: peptidyl-leucine racemization +namespace: biological_process +alt_id: GO:0018093 +alt_id: GO:0018375 +def: "The racemization of peptidyl-leucine." [RESID:AA0197] +subset: gosubset_prok +xref: RESID:AA0197 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019131 +name: tripeptidyl-peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] +synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] +xref: EC:3.4.14.9 +xref: MetaCyc:3.4.14.9-RXN +is_obsolete: true +replaced_by: GO:0008240 + +[Term] +id: GO:0019132 +name: C-terminal processing peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102] +synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102] +synonym: "protease Re" RELATED [EC:3.4.21.102] +synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102] +synonym: "Tsp protease" NARROW [EC:3.4.21.102] +xref: EC:3.4.21.102 +xref: MetaCyc:3.4.21.102-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0019133 +name: choline monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7] +subset: gosubset_prok +synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7] +xref: EC:1.14.15.7 +xref: MetaCyc:RXN1F-357 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0019134 +name: glucosamine-1-phosphate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 1-phosphate = CoA + N-acetyl-D-glucosamine 1-phosphate." [EC:2.3.1.157] +subset: gosubset_prok +synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] +synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] +xref: EC:2.3.1.157 +xref: MetaCyc:2.3.1.157-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0019135 +name: deoxyhypusine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29] +synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29] +synonym: "deoxyhypusine hydroxylase activity" EXACT [] +synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29] +synonym: "DOHH activity" EXACT [EC:1.14.99.29] +xref: EC:1.14.99.29 +xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0019136 +name: deoxynucleoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145] +subset: gosubset_prok +synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145] +synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145] +synonym: "Dm-dNK" RELATED [EC:2.7.1.145] +synonym: "ms-dNK" RELATED [EC:2.7.1.145] +synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145] +synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] +synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] +synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] +xref: EC:2.7.1.145 +xref: MetaCyc:2.7.1.145-RXN +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0019137 +name: thioglucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147] +synonym: "myrosinase activity" EXACT [] +synonym: "sinigrase activity" EXACT [] +synonym: "sinigrinase activity" EXACT [] +synonym: "thioglucoside glucohydrolase activity" EXACT [] +xref: EC:3.2.1.147 +xref: MetaCyc:3.2.1.147-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0019139 +name: cytokinin dehydrogenase activity +namespace: molecular_function +alt_id: GO:0046420 +def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12] +synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] +synonym: "cytokinin oxidase activity" RELATED [] +synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12] +synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] +xref: EC:1.5.99.12 +xref: MetaCyc:1.5.99.12-RXN +xref: MetaCyc:PWY-2841 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0019140 +name: inositol 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64] +synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64] +synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64] +synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64] +synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64] +synonym: "myo-inositol 3-kinase activity" EXACT [] +synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64] +xref: EC:2.7.1.64 +xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0019141 +name: 2-dehydropantolactone reductase (B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214] +synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214] +synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT [] +synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] +synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214] +synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] +xref: EC:1.1.1.214 +xref: MetaCyc:DEHYDROPANTLACRED-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019142 +name: 2-hydroxyglutarate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA." [EC:2.3.3.11] +comment: Note that this function was formerly EC:4.1.3.9. +synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11] +synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11] +synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11] +synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] +synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] +synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11] +xref: EC:2.3.3.11 +xref: MetaCyc:HYDGLUTSYN-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0019143 +name: 3-deoxy-manno-octulosonate-8-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45] +subset: gosubset_prok +synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45] +xref: EC:3.1.3.45 +xref: MetaCyc:KDO-8PPHOSPHAT-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019144 +name: ADP-sugar diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21] +synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21] +synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21] +synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21] +synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21] +xref: EC:3.6.1.21 +xref: MetaCyc:ADPSUGPPHOSPHAT-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0019145 +name: aminobutyraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19] +subset: gosubset_prok +synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19] +synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19] +synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19] +synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19] +synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19] +xref: EC:1.2.1.19 +xref: MetaCyc:AMINOBUTDEHYDROG-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019146 +name: arabinose-5-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.13] +subset: gosubset_prok +synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13] +synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13] +synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13] +synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13] +xref: EC:5.3.1.13 +xref: MetaCyc:DARAB5PISOM-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0019147 +name: (R)-aminopropanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+." [EC:1.1.1.75] +synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] +synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75] +synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] +synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] +synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75] +synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] +synonym: "L-aminopropanol dehydrogenase activity" EXACT [] +xref: EC:1.1.1.75 +xref: MetaCyc:AMINOPROPDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019148 +name: D-cysteine desulfhydrase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15] +subset: gosubset_prok +synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15] +synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15] +synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15] +xref: EC:4.4.1.15 +xref: MetaCyc:DCYSDESULF-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0019149 +name: 3-chloro-D-alanine dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2] +synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2] +synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2] +synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2] +xref: EC:4.5.1.2 +xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0019150 +name: D-ribulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47] +subset: gosubset_prok +synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47] +synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47] +xref: EC:2.7.1.47 +xref: MetaCyc:D-RIBULOKIN-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0019151 +name: galactose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48] +subset: gosubset_prok +synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] +synonym: "D-galactose 1-dehydrogenase activity" EXACT [] +synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] +synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48] +synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] +xref: EC:1.1.1.48 +xref: MetaCyc:GALACTODEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019152 +name: acetoin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [EC:1.1.1.5] +subset: gosubset_prok +synonym: "diacetyl reductase activity" EXACT [EC:1.1.1.5] +xref: EC:1.1.1.5 +xref: MetaCyc:ACETOINDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019153 +name: protein-disulfide reductase (glutathione) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2] +subset: gosubset_prok +synonym: "glutaredoxin reductase" RELATED [] +synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2] +synonym: "glutathione-insulin transhydrogenase activity" EXACT [] +synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] +synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] +synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2] +synonym: "insulin reductase activity" EXACT [EC:1.8.4.2] +synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2] +synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2] +synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2] +synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2] +synonym: "protein-disulphide reductase (glutathione) activity" EXACT [] +synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2] +synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2] +synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] +xref: EC:1.8.4.2 +xref: MetaCyc:PRODISULFREDUCT-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0019154 +name: glycolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + acceptor = glyoxylate + reduced acceptor." [EC:1.1.99.14] +synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14] +synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14] +synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14] +synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14] +xref: EC:1.1.99.14 +xref: MetaCyc:GLYCOLATEDEHYDRO-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0019155 +name: 3-(imidazol-5-yl)lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111] +synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111] +synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111] +xref: EC:1.1.1.111 +xref: MetaCyc:IMILACTDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019156 +name: isoamylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68] +subset: gosubset_prok +synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68] +synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68] +xref: EC:3.2.1.68 +xref: MetaCyc:3.2.1.68-RXN +is_a: GO:0004133 ! glycogen debranching enzyme activity +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0019157 +name: malate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + O2 = oxaloacetate + H2O2." [EC:1.1.3.3] +synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [EC:1.1.3.3] +synonym: "FAD-dependent malate oxidase activity" EXACT [EC:1.1.3.3] +synonym: "malic dehydrogenase II" RELATED [EC:1.1.3.3] +synonym: "malic oxidase activity" EXACT [EC:1.1.3.3] +xref: EC:1.1.3.3 +xref: MetaCyc:MALOX-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0019158 +name: mannokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] +subset: gosubset_prok +synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7] +synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7] +synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7] +xref: EC:2.7.1.7 +xref: MetaCyc:MANNKIN-RXN +is_a: GO:0004396 ! hexokinase activity + +[Term] +id: GO:0019159 +name: nicotinamide-nucleotide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42] +synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] +synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42] +synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] +synonym: "NMN amidohydrolase" NARROW [] +synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42] +xref: EC:3.5.1.42 +xref: MetaCyc:NMNAMIDOHYDRO-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0019160 +name: NMN nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinamide D-ribonucleotide + H2O = nicotinamide + D-ribose 5-phosphate." [EC:3.2.2.14] +synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14] +synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14] +synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14] +synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14] +synonym: "NMNase activity" EXACT [EC:3.2.2.14] +synonym: "NMNGhase activity" EXACT [EC:3.2.2.14] +xref: EC:3.2.2.14 +xref: MetaCyc:NMNNUCLEOSID-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0019161 +name: diamine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29] +synonym: "amine transaminase activity" EXACT [EC:2.6.1.29] +synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29] +synonym: "diamine aminotransferase activity" EXACT [] +synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29] +synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29] +xref: EC:2.6.1.29 +xref: MetaCyc:DIAMTRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019162 +name: pyridoxamine-oxaloacetate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxamine + oxaloacetate = pyridoxal + L-aspartate." [EC:2.6.1.31] +synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] +synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT [] +synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] +xref: EC:2.6.1.31 +xref: MetaCyc:PYROXALTRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019163 +name: pyridoxamine-phosphate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54] +synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54] +synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54] +synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54] +synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54] +synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT [] +xref: EC:2.6.1.54 +xref: MetaCyc:PYRDAMPTRANS-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019164 +name: pyruvate synthase activity +namespace: molecular_function +alt_id: GO:0018696 +def: "Catalysis of the reaction: pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.1] +subset: gosubset_prok +synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1] +synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1] +synonym: "pyruvate-ferredoxin reductase activity" EXACT [] +synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1] +synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] +synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] +xref: EC:1.2.7.1 +xref: MetaCyc:PYRUFLAVREDUCT-RXN +xref: UM-BBD_enzymeID:e0417 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0019165 +name: thiamin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamin = ADP + thiamin phosphate." [EC:2.7.1.89] +synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89] +synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89] +synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89] +synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89] +synonym: "thiamine kinase activity" EXACT [] +xref: EC:2.7.1.89 +xref: MetaCyc:THIKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0019166 +name: trans-2-enoyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] +synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38] +synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38] +synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38] +xref: EC:1.3.1.38 +xref: MetaCyc:TRANSENOYLCOARED-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019168 +name: 2-octaprenylphenol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] +xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0019170 +name: methylglyoxal reductase (NADH-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78] +synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78] +synonym: "D-lactaldehyde dehydrogenase activity" EXACT [] +synonym: "methylglyoxal reductase activity" EXACT [] +xref: EC:1.1.1.78 +xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019171 +name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: CH3-CHOH-CH2-[CH2]n-CO-[acyl-carrier protein] = H2O + CH3-CH-CH-[CH2]n-CO-[acyl-carrier protein]." [EC:4.2.1.-, GOC:ai] +subset: gosubset_prok +synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT [] +xref: EC:4.2.1.- +xref: Reactome:76135 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0019172 +name: glyoxalase III activity +namespace: molecular_function +def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [MetaCyc:GLYOXIII-RXN] +comment: Note that this term was reinstated from obsolete. +xref: MetaCyc:GLYOXIII-RXN +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0019173 +name: pyrimidine phosphatase activity +namespace: molecular_function +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019174 +name: tetrahydrothiophene 1-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN] +xref: MetaCyc:THTOREDUCT-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0019175 +name: alpha-ribazole-5'-P phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-ribazole-5'-phosphate = alpha-ribazole + phosphate." [MetaCyc:RIBAZOLEPHOSPHAT-RXN] +subset: gosubset_prok +xref: EC:3.1.3.- +xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019176 +name: dihydroneopterin monophosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] +synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] +xref: EC:3.6.1.- +xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0019177 +name: dihydroneopterin triphosphate pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] +xref: EC:3.6.1.- +xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0019178 +name: NADP phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN] +xref: EC:3.1.3.- +xref: MetaCyc:NADPPHOSPHAT-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019179 +name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33] +synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT [] +synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33] +synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] +synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] +synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] +synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] +synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] +synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33] +xref: EC:2.6.1.33 +xref: MetaCyc:2.6.1.33-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019180 +name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate." [EC:2.6.1.59] +synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59] +synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] +synonym: "dTDP-fucosamine aminotransferase activity" EXACT [] +synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59] +synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] +xref: EC:2.6.1.59 +xref: MetaCyc:2.6.1.59-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019181 +name: halohydrin hydrogen-halide-lyase activity +namespace: molecular_function +xref: EC:4.5.1.- +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0019182 +name: histamine-gated chloride channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0019183 +name: histamine-gated chloride channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] +is_a: GO:0034707 ! chloride channel complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0019184 +name: nonribosomal peptide biosynthetic process +namespace: biological_process +def: "The process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nonribosomal peptide anabolism" EXACT [] +synonym: "nonribosomal peptide biosynthesis" EXACT [] +synonym: "nonribosomal peptide formation" EXACT [] +synonym: "nonribosomal peptide synthesis" EXACT [] +is_a: GO:0043043 ! peptide biosynthetic process + +[Term] +id: GO:0019185 +name: snRNA-activating protein complex +namespace: cellular_component +def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] +synonym: "SNAPc" EXACT [] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0019186 +name: acyl-CoA N-acyltransferase activity +namespace: molecular_function +xref: EC:2.3.1.- +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0019187 +name: beta-1,4-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming a beta-1,4-linkage." [GOC:mcc, PMID:8166646] +xref: EC:2.4.1.- +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0019191 +name: cellobiose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019190 +def: "Catalysis of the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +synonym: "cellobiose permease activity" EXACT [] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0019194 +name: sorbose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019193 +def: "Catalysis of the transfer of sorbose from one side of the membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "sorbose porter activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0019196 +name: galactosamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019195 +def: "Catalysis of the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +synonym: "galactosamine porter activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0019197 +name: phosphoenolpyruvate-dependent sugar phosphotransferase complex +namespace: cellular_component +def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0019198 +name: transmembrane receptor protein phosphatase activity +namespace: molecular_function +def: "The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner." [GOC:hjd] +xref: EC:3.1.3.- +is_a: GO:0004721 ! phosphoprotein phosphatase activity +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0019199 +name: transmembrane receptor protein kinase activity +namespace: molecular_function +subset: gosubset_prok +xref: EC:2.7.11.- +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0019200 +name: carbohydrate kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl] +subset: gosubset_prok +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0019201 +name: nucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0019202 +name: amino acid kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] +subset: gosubset_prok +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0019203 +name: carbohydrate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019204 +name: nucleotide phosphatase activity +namespace: molecular_function +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019205 +name: nucleobase, nucleoside, nucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] +subset: gosubset_prok +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0019206 +name: nucleoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai] +subset: gosubset_prok +xref: Reactome:6991 +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0019207 +name: kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] +subset: gosubset_prok +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0019208 +name: phosphatase regulator activity +namespace: molecular_function +def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0019209 +name: kinase activator activity +namespace: molecular_function +def: "Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0019210 +name: kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] +subset: gosubset_prok +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0019211 +name: phosphatase activator activity +namespace: molecular_function +def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0019212 +name: phosphatase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0019213 +name: deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0019214 +name: surfactant activity +namespace: molecular_function +def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents involvement in a process. +is_obsolete: true +consider: GO:0050828 + +[Term] +id: GO:0019215 +name: intermediate filament binding +namespace: molecular_function +def: "Interacting selectively with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0019216 +name: regulation of lipid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of lipid metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0019217 +name: regulation of fatty acid metabolic process +namespace: biological_process +alt_id: GO:0006632 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of fatty acid metabolism" EXACT [] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0019218 +name: regulation of steroid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of steroid metabolism" EXACT [] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0019219 +name: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process + +[Term] +id: GO:0019220 +name: regulation of phosphate metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of phosphate metabolism" EXACT [] +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: regulates GO:0006796 ! phosphate metabolic process + +[Term] +id: GO:0019221 +name: cytokine-mediated signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "cytokine mediated signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0019222 +name: regulation of metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of metabolism" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0019226 +name: transmission of nerve impulse +namespace: biological_process +def: "The sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation." [http://cancerweb.ncl.ac.uk] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0050877 ! neurological system process + +[Term] +id: GO:0019227 +name: action potential propagation +namespace: biological_process +def: "A neurological process that causes the sequential depolarization of a neuron's cell membrane along an axon." [GOC:isa_complete] +is_a: GO:0050877 ! neurological system process +relationship: part_of GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0019228 +name: regulation of action potential in neuron +namespace: biological_process +def: "The process that modulates the membrane potential involved in the propagation of a signal in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001508 ! regulation of action potential + +[Term] +id: GO:0019229 +name: regulation of vasoconstriction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042310 ! vasoconstriction + +[Term] +id: GO:0019230 +name: proprioception +namespace: biological_process +def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [http://www.onelook.com/, ISBN:072168677X] +is_a: GO:0007600 ! sensory perception +relationship: part_of GO:0050884 ! neuromuscular process controlling posture + +[Term] +id: GO:0019231 +name: perception of static position +namespace: biological_process +def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X] +is_a: GO:0019230 ! proprioception + +[Term] +id: GO:0019232 +name: perception of rate of movement +namespace: biological_process +def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah] +synonym: "kinesthesia" EXACT [] +is_a: GO:0019230 ! proprioception + +[Term] +id: GO:0019233 +name: sensory perception of pain +namespace: biological_process +def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances." [http://www.onelook.com/] +synonym: "nociception" EXACT [] +synonym: "perception of physiological pain" NARROW [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0019234 +name: sensory perception of fast pain +namespace: biological_process +def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/] +is_a: GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0019235 +name: sensory perception of slow pain +namespace: biological_process +def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/] +is_a: GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0019236 +name: response to pheromone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] +subset: gosubset_prok +synonym: "pheromone response" EXACT [] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0019237 +name: centromeric DNA binding +namespace: molecular_function +def: "Interacting selectively with centromere-associated DNA, usually characterized by highly repetitive sequences." [GOC:jl, ISBN:0321000382] +synonym: "centromere binding" BROAD [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0019238 +name: cyclohydrolase activity +namespace: molecular_function +subset: gosubset_prok +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0019239 +name: deaminase activity +namespace: molecular_function +def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0019240 +name: citrulline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "citrulline anabolism" EXACT [] +synonym: "citrulline biosynthesis" EXACT [] +synonym: "citrulline formation" EXACT [] +synonym: "citrulline synthesis" EXACT [] +xref: MetaCyc:CITRULBIO-PWY +is_a: GO:0000052 ! citrulline metabolic process +is_a: GO:0044271 ! nitrogen compound biosynthetic process + +[Term] +id: GO:0019241 +name: citrulline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "citrulline breakdown" EXACT [] +synonym: "citrulline catabolism" EXACT [] +synonym: "citrulline degradation" EXACT [] +xref: MetaCyc:CITRULLINE-DEG-PWY +is_a: GO:0000052 ! citrulline metabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0019242 +name: methylglyoxal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] +subset: gosubset_prok +synonym: "methylglyoxal anabolism" EXACT [] +synonym: "methylglyoxal biosynthesis" EXACT [] +synonym: "methylglyoxal formation" EXACT [] +synonym: "methylglyoxal synthesis" EXACT [] +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process + +[Term] +id: GO:0019243 +name: methylglyoxal catabolic process to D-lactate +namespace: biological_process +def: "The breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai] +subset: gosubset_prok +synonym: "D-lactate biosynthesis from methylglyoxal" EXACT [] +synonym: "D-lactate biosynthetic process from methylglyoxal" EXACT [] +synonym: "glyoxalase system" RELATED [] +synonym: "methylglyoxal breakdown to D-lactate" EXACT [] +synonym: "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione" EXACT [] +synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT [] +synonym: "methylglyoxal degradation to D-lactate" EXACT [] +synonym: "methylglyoxal detoxification" RELATED [] +xref: MetaCyc:PWY-901 +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0051595 ! response to methylglyoxal +is_a: GO:0051596 ! methylglyoxal catabolic process + +[Term] +id: GO:0019244 +name: lactate biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactate anabolism from pyruvate" EXACT [] +synonym: "lactate formation from pyruvate" EXACT [] +synonym: "lactate synthesis from pyruvate" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0019249 ! lactate biosynthetic process + +[Term] +id: GO:0019245 +name: D(-)-lactate biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "D(-)-lactate anabolism from pyruvate" EXACT [] +synonym: "D(-)-lactate formation from pyruvate" EXACT [] +synonym: "D(-)-lactate synthesis from pyruvate" EXACT [] +is_a: GO:0019244 ! lactate biosynthetic process from pyruvate + +[Term] +id: GO:0019246 +name: L(+)-lactate biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L(+)lactate from other compounds, including pyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L(+)-lactate anabolism from pyruvate" EXACT [] +synonym: "L(+)-lactate formation from pyruvate" EXACT [] +synonym: "L(+)-lactate synthesis from pyruvate" EXACT [] +is_a: GO:0019244 ! lactate biosynthetic process from pyruvate + +[Term] +id: GO:0019247 +name: lactate racemization +namespace: biological_process +def: "Partial conversion of one lactate enantiomorph into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006089 ! lactate metabolic process + +[Term] +id: GO:0019248 +name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-lactate from other compounds, including methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:go_curators] +subset: gosubset_prok +synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT [] +synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT [] +synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT [] +xref: MetaCyc:MGLDLCTANA-PWY +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0019249 ! lactate biosynthetic process + +[Term] +id: GO:0019249 +name: lactate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactate anabolism" EXACT [] +synonym: "lactate biosynthesis" EXACT [] +synonym: "lactate formation" EXACT [] +synonym: "lactate synthesis" EXACT [] +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0019250 +name: aerobic cobalamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators] +subset: gosubset_prok +synonym: "aerobic cobalamin anabolism" EXACT [] +synonym: "aerobic cobalamin biosynthesis" EXACT [] +synonym: "aerobic cobalamin formation" EXACT [] +synonym: "aerobic cobalamin synthesis" EXACT [] +synonym: "aerobic vitamin B12 biosynthesis" EXACT [] +synonym: "aerobic vitamin B12 biosynthetic process" EXACT [] +synonym: "cobalamin biosynthesis, aerobic" EXACT [] +synonym: "cobalamin biosynthetic process, aerobic" EXACT [] +synonym: "vitamin B12 biosynthesis, aerobic" EXACT [] +synonym: "vitamin B12 biosynthetic process, aerobic" EXACT [] +xref: MetaCyc:P381-PWY +is_a: GO:0009236 ! cobalamin biosynthetic process + +[Term] +id: GO:0019251 +name: anaerobic cobalamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators] +subset: gosubset_prok +synonym: "anaerobic cobalamin anabolism" EXACT [] +synonym: "anaerobic cobalamin biosynthesis" EXACT [] +synonym: "anaerobic cobalamin formation" EXACT [] +synonym: "anaerobic cobalamin synthesis" EXACT [] +synonym: "anaerobic vitamin B12 biosynthesis" EXACT [] +synonym: "anaerobic vitamin B12 biosynthetic process" EXACT [] +synonym: "cobalamin biosynthesis, anaerobic" EXACT [] +synonym: "cobalamin biosynthetic process, anaerobic" EXACT [] +synonym: "vitamin B12 biosynthesis, anaerobic" EXACT [] +synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT [] +xref: MetaCyc:COBALSYN-PWY +is_a: GO:0009236 ! cobalamin biosynthetic process + +[Term] +id: GO:0019252 +name: starch biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai] +subset: gosubset_prok +synonym: "starch anabolism" EXACT [] +synonym: "starch biosynthesis" EXACT [] +synonym: "starch formation" EXACT [] +synonym: "starch synthesis" EXACT [] +xref: MetaCyc:CELSYN-PWY +xref: MetaCyc:PWY-622 +is_a: GO:0005982 ! starch metabolic process +is_a: GO:0009250 ! glucan biosynthetic process + +[Term] +id: GO:0019253 +name: reductive pentose-phosphate cycle +namespace: biological_process +def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684] +comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. +synonym: "C3 photosynthesis" NARROW [] +synonym: "Calvin cycle" NARROW [] +xref: MetaCyc:CALVIN-PWY +is_a: GO:0019685 ! photosynthesis, dark reaction +relationship: part_of GO:0015977 ! carbon utilization by fixation of carbon dioxide + +[Term] +id: GO:0019254 +name: carnitine metabolic process, CoA-linked +namespace: biological_process +def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators] +subset: gosubset_prok +synonym: "carnitine metabolism, CoA-linked" EXACT [] +xref: MetaCyc:CARNMET-PWY +is_a: GO:0009437 ! carnitine metabolic process + +[Term] +id: GO:0019255 +name: glucose 1-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] +subset: gosubset_prok +synonym: "glucose 1-phosphate metabolism" EXACT [] +xref: MetaCyc:GLUCOSE1PMETAB-PWY +is_a: GO:0006006 ! glucose metabolic process + +[Term] +id: GO:0019256 +name: acrylonitrile catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai] +subset: gosubset_prok +synonym: "acrylonitrile breakdown" EXACT [] +synonym: "acrylonitrile catabolism" EXACT [] +synonym: "acrylonitrile degradation" EXACT [] +xref: MetaCyc:P344-PWY +is_a: GO:0018865 ! acrylonitrile metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0050899 ! nitrile catabolic process + +[Term] +id: GO:0019257 +name: 4-nitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai] +subset: gosubset_prok +synonym: "4-nitrotoluene metabolism" EXACT [] +synonym: "4NT metabolic process" EXACT [] +synonym: "4NT metabolism" EXACT [] +is_a: GO:0019326 ! nitrotoluene metabolic process + +[Term] +id: GO:0019258 +name: 4-nitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] +subset: gosubset_prok +synonym: "4-nitrotoluene breakdown" EXACT [] +synonym: "4-nitrotoluene catabolism" EXACT [] +synonym: "4-nitrotoluene degradation" EXACT [] +synonym: "4NT catabolic process" EXACT [] +synonym: "4NT catabolism" EXACT [] +xref: MetaCyc:P421-PWY +is_a: GO:0019257 ! 4-nitrotoluene metabolic process +is_a: GO:0046263 ! nitrotoluene catabolic process + +[Term] +id: GO:0019260 +name: 1,2-dichloroethane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators] +subset: gosubset_prok +synonym: "1,2-dichloroethane breakdown" EXACT [] +synonym: "1,2-dichloroethane catabolism" EXACT [] +synonym: "1,2-dichloroethane degradation" EXACT [] +xref: MetaCyc:12DICHLORETHDEG-PWY +is_a: GO:0018899 ! 1,2-dichloroethane metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0019261 +name: 1,4-dichlorobenzene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai] +subset: gosubset_prok +synonym: "1,4-dichlorobenzene breakdown" EXACT [] +synonym: "1,4-dichlorobenzene catabolism" EXACT [] +synonym: "1,4-dichlorobenzene degradation" EXACT [] +xref: MetaCyc:14DICHLORBENZDEG-PWY +is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0019262 +name: N-acetylneuraminate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylneuraminate breakdown" EXACT [] +synonym: "N-acetylneuraminate catabolism" EXACT [] +synonym: "N-acetylneuraminate degradation" EXACT [] +xref: MetaCyc:P441-PWY +is_a: GO:0006054 ! N-acetylneuraminate metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0019263 +name: adamantanone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] +subset: gosubset_prok +synonym: "adamantanone breakdown" EXACT [] +synonym: "adamantanone catabolism" EXACT [] +synonym: "adamantanone degradation" EXACT [] +xref: MetaCyc:P481-PWY +is_a: GO:0018866 ! adamantanone metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019264 +name: glycine biosynthetic process from serine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine anabolism from serine" EXACT [] +synonym: "glycine formation from serine" EXACT [] +synonym: "glycine synthesis from serine" EXACT [] +xref: MetaCyc:GLYSYN-PWY +is_a: GO:0006545 ! glycine biosynthetic process +is_a: GO:0006563 ! L-serine metabolic process + +[Term] +id: GO:0019265 +name: glycine biosynthetic process, by transamination of glyoxylate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine anabolism, by transamination of glyoxylate" EXACT [] +synonym: "glycine formation, by transamination of glyoxylate" EXACT [] +synonym: "glycine synthesis, by transamination of glyoxylate" EXACT [] +xref: MetaCyc:SERGLYSII-PWY +is_a: GO:0006545 ! glycine biosynthetic process + +[Term] +id: GO:0019266 +name: asparagine biosynthetic process from oxaloacetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "asparagine anabolism from oxaloacetate" EXACT [] +synonym: "asparagine formation from oxaloacetate" EXACT [] +synonym: "asparagine synthesis from oxaloacetate" EXACT [] +xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS +is_a: GO:0006107 ! oxaloacetate metabolic process +is_a: GO:0006529 ! asparagine biosynthetic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0019267 +name: asparagine biosynthetic process from cysteine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators] +subset: gosubset_prok +synonym: "asparagine anabolism from cysteine" EXACT [] +synonym: "asparagine formation from cysteine" EXACT [] +synonym: "asparagine synthesis from cysteine" EXACT [] +xref: MetaCyc:ASPSYNII-PWY +is_a: GO:0006529 ! asparagine biosynthetic process +is_a: GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:0019268 +name: glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function. +synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +is_obsolete: true +replaced_by: GO:0004353 +replaced_by: GO:0006537 + +[Term] +id: GO:0019269 +name: glutamate biosynthetic process, using glutamate synthase (NADPH) +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators] +comment: This term was made obsolete because it refers to a molecular function. +synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT [] +is_obsolete: true +replaced_by: GO:0004355 +replaced_by: GO:0006537 + +[Term] +id: GO:0019270 +name: aerobactin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] +subset: gosubset_prok +synonym: "aerobactin anabolism" EXACT [] +synonym: "aerobactin biosynthesis" EXACT [] +synonym: "aerobactin formation" EXACT [] +synonym: "aerobactin synthesis" EXACT [] +xref: MetaCyc:AEROBACTINSYN-PWY +is_a: GO:0009085 ! lysine biosynthetic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process +is_a: GO:0046442 ! aerobactin metabolic process + +[Term] +id: GO:0019271 +name: aerobactin transport +namespace: biological_process +def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of, within or between cells. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0019272 +name: L-alanine biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-alanine anabolism from pyruvate" EXACT [] +synonym: "L-alanine formation from pyruvate" EXACT [] +synonym: "L-alanine synthesis from pyruvate" EXACT [] +xref: MetaCyc:ALANINE-SYN2-PWY +xref: MetaCyc:ALANINE-VALINESYN-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0042852 ! L-alanine biosynthetic process + +[Term] +id: GO:0019273 +name: L-alanine biosynthetic process via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-alanine anabolism via ornithine" EXACT [] +synonym: "L-alanine formation via ornithine" EXACT [] +synonym: "L-alanine synthesis via ornithine" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0042852 ! L-alanine biosynthetic process + +[Term] +id: GO:0019276 +name: UDP-N-acetylgalactosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-N-acetylgalactosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0019277 +name: UDP-N-acetylgalactosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-N-acetylgalactosamine anabolism" EXACT [] +synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT [] +synonym: "UDP-N-acetylgalactosamine formation" EXACT [] +synonym: "UDP-N-acetylgalactosamine synthesis" EXACT [] +xref: MetaCyc:UDPNACETYLGALSYN-PWY +is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0019278 +name: UDP-N-acetylgalactosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-N-acetylgalactosamine breakdown" EXACT [] +synonym: "UDP-N-acetylgalactosamine catabolism" EXACT [] +synonym: "UDP-N-acetylgalactosamine degradation" EXACT [] +is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0019279 +name: methionine biosynthetic process from L-homoserine via cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine anabolism from L-homoserine via cystathionine" EXACT [] +synonym: "methionine formation from L-homoserine via cystathionine" EXACT [] +synonym: "methionine synthesis from L-homoserine via cystathionine" EXACT [] +xref: MetaCyc:HOMOSER-METSYN-PWY +is_a: GO:0009086 ! methionine biosynthetic process +is_a: GO:0009092 ! homoserine metabolic process + +[Term] +id: GO:0019280 +name: methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [] +synonym: "methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [] +synonym: "methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [] +xref: MetaCyc:HSERMETANA-PWY +is_a: GO:0019279 ! methionine biosynthetic process from L-homoserine via cystathionine + +[Term] +id: GO:0019281 +name: methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [] +synonym: "methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [] +synonym: "methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [] +xref: MetaCyc:MET-SAM-PWY +is_a: GO:0019279 ! methionine biosynthetic process from L-homoserine via cystathionine + +[Term] +id: GO:0019282 +name: methionine biosynthetic process, direct, from O-acetyl-L-homoserine +namespace: biological_process +def: "The direct chemical reactions and pathways resulting in the formation of methionine from other compounds, including O-acetyl-L-homoserine." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [] +synonym: "methionine formation, direct, from O-acetyl-L-homoserine" EXACT [] +synonym: "methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [] +is_a: GO:0009086 ! methionine biosynthetic process + +[Term] +id: GO:0019283 +name: methionine biosynthetic process from O-phospho-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [] +synonym: "methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [] +synonym: "methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [] +is_a: GO:0009086 ! methionine biosynthetic process + +[Term] +id: GO:0019284 +name: methionine biosynthetic process from S-adenosylmethionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including S-adenosylmethionine." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine anabolism from S-adenosylmethionine" EXACT [] +synonym: "methionine biosynthesis from S-adenosyl methionine" EXACT [] +synonym: "methionine biosynthetic process from S-adenosyl methionine" EXACT [] +synonym: "methionine formation from S-adenosylmethionine" EXACT [] +synonym: "methionine synthesis from S-adenosylmethionine" EXACT [] +is_a: GO:0009086 ! methionine biosynthetic process +is_a: GO:0046500 ! S-adenosylmethionine metabolic process +relationship: part_of GO:0033353 ! S-adenosylmethionine cycle + +[Term] +id: GO:0019285 +name: glycine betaine biosynthetic process from choline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl] +subset: gosubset_prok +synonym: "glycine betaine anabolism from choline" EXACT [] +synonym: "glycine betaine formation from choline" EXACT [] +synonym: "glycine betaine synthesis from choline" EXACT [] +synonym: "N-trimethylglycine biosynthesis from choline" EXACT [] +synonym: "N-trimethylglycine biosynthetic process from choline" EXACT [] +xref: MetaCyc:BETSYN-PWY +xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY +xref: MetaCyc:P542-PWY +is_a: GO:0019695 ! choline metabolic process +is_a: GO:0031456 ! glycine betaine biosynthetic process + +[Term] +id: GO:0019286 +name: glycine betaine biosynthetic process from glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine betaine anabolism from glycine" EXACT [] +synonym: "glycine betaine formation from glycine" EXACT [] +synonym: "glycine betaine synthesis from glycine" EXACT [] +synonym: "N-trimethylglycine biosynthesis from glycine" EXACT [] +synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT [] +xref: MetaCyc:P541-PWY +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0031456 ! glycine betaine biosynthetic process + +[Term] +id: GO:0019287 +name: isopentenyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922] +subset: gosubset_prok +synonym: "Ac-MVA pathway" EXACT [PMID:14517367] +synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367] +synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process + +[Term] +id: GO:0019288 +name: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY] +subset: gosubset_prok +synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT [] +synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT [] +synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT [] +synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT [] +synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT [] +synonym: "non-MVA pathway" EXACT [] +xref: MetaCyc:NONMEVIPP-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process + +[Term] +id: GO:0019289 +name: rhizobactin 1021 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] +subset: gosubset_prok +synonym: "rhizobactin 1021 anabolism" EXACT [] +synonym: "rhizobactin 1021 biosynthesis" EXACT [] +synonym: "rhizobactin 1021 formation" EXACT [] +synonym: "rhizobactin 1021 synthesis" EXACT [] +xref: MetaCyc:PWY-761 +is_a: GO:0019540 ! siderophore biosynthetic process from catechol +is_a: GO:0046494 ! rhizobactin 1021 metabolic process + +[Term] +id: GO:0019290 +name: siderophore biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:go_curators] +comment: See also the biological process term 'nonribosomal peptide biosynthetic process ; GO:0019184'. +subset: gosubset_prok +synonym: "siderochrome biosynthesis" NARROW [] +synonym: "siderochrome biosynthetic process" NARROW [] +synonym: "siderophore anabolism" EXACT [] +synonym: "siderophore biosynthesis" EXACT [] +synonym: "siderophore formation" EXACT [] +synonym: "siderophore synthesis" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0051188 ! cofactor biosynthetic process + +[Term] +id: GO:0019292 +name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT [] +synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT [] +synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT [] +synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT [] +xref: MetaCyc:TYRSYN +is_a: GO:0006571 ! tyrosine biosynthetic process + +[Term] +id: GO:0019293 +name: tyrosine biosynthetic process, by oxidation of phenylalanine +namespace: biological_process +alt_id: GO:0019291 +def: "The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine." [GOC:go_curators] +subset: gosubset_prok +synonym: "tyrosine anabolism from chorismate via L-phenylalanine" EXACT [] +synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT [] +synonym: "tyrosine biosynthetic process from chorismate via L-phenylalanine" EXACT [] +synonym: "tyrosine formation from chorismate via L-phenylalanine" EXACT [] +synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT [] +synonym: "tyrosine synthesis from chorismate via L-phenylalanine" EXACT [] +synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT [] +is_a: GO:0006558 ! L-phenylalanine metabolic process +is_a: GO:0006571 ! tyrosine biosynthetic process + +[Term] +id: GO:0019294 +name: ketodeoxyoctanoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketodeoxyoctanoate, 2-keto-3-deoxy-D-octaonate, an acid present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3-deoxy-D-manno-octulosonic acid biosynthetic process" EXACT [] +synonym: "KDO biosynthesis" EXACT [] +synonym: "KDO biosynthetic process" EXACT [] +synonym: "ketodeoxyoctanoate anabolism" EXACT [] +synonym: "ketodeoxyoctanoate biosynthesis" EXACT [] +synonym: "ketodeoxyoctanoate formation" EXACT [] +synonym: "ketodeoxyoctanoate synthesis" EXACT [] +xref: MetaCyc:KDOSYN-PWY +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046400 ! ketodeoxyoctanoate metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0019295 +name: coenzyme M biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684] +subset: gosubset_prok +synonym: "coenzyme M anabolism" EXACT [] +synonym: "coenzyme M biosynthesis" EXACT [] +synonym: "coenzyme M formation" EXACT [] +synonym: "coenzyme M synthesis" EXACT [] +xref: MetaCyc:P261-PWY +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0019296 ! coenzyme M metabolic process + +[Term] +id: GO:0019296 +name: coenzyme M metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] +subset: gosubset_prok +synonym: "coenzyme M metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0019297 +name: coenzyme B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] +subset: gosubset_prok +synonym: "coenzyme B metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0019298 +name: coenzyme B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051] +subset: gosubset_prok +synonym: "coenzyme B anabolism" EXACT [] +synonym: "coenzyme B biosynthesis" EXACT [] +synonym: "coenzyme B formation" EXACT [] +synonym: "coenzyme B synthesis" EXACT [] +xref: MetaCyc:P241-PWY +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0019297 ! coenzyme B metabolic process + +[Term] +id: GO:0019299 +name: rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "rhamnose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0019300 +name: rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "rhamnose anabolism" EXACT [] +synonym: "rhamnose biosynthesis" EXACT [] +synonym: "rhamnose formation" EXACT [] +synonym: "rhamnose synthesis" EXACT [] +is_a: GO:0019299 ! rhamnose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0019301 +name: rhamnose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "rhamnose breakdown" EXACT [] +synonym: "rhamnose catabolism" EXACT [] +synonym: "rhamnose degradation" EXACT [] +xref: MetaCyc:RHAMCAT-PWY +is_a: GO:0019299 ! rhamnose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019302 +name: D-ribose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-ribose anabolism" EXACT [] +synonym: "D-ribose biosynthesis" EXACT [] +synonym: "D-ribose formation" EXACT [] +synonym: "D-ribose synthesis" EXACT [] +is_a: GO:0006014 ! D-ribose metabolic process +is_a: GO:0019322 ! pentose biosynthetic process + +[Term] +id: GO:0019303 +name: D-ribose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-ribose breakdown" EXACT [] +synonym: "D-ribose catabolism" EXACT [] +synonym: "D-ribose degradation" EXACT [] +xref: MetaCyc:RIBOKIN-PWY +is_a: GO:0006014 ! D-ribose metabolic process +is_a: GO:0019323 ! pentose catabolic process + +[Term] +id: GO:0019304 +name: anaerobic rhamnose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic rhamnose breakdown" EXACT [] +synonym: "anaerobic rhamnose catabolism" EXACT [] +synonym: "anaerobic rhamnose degradation" EXACT [] +is_a: GO:0019301 ! rhamnose catabolic process + +[Term] +id: GO:0019305 +name: dTDP-rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "dTDP-rhamnose anabolism" EXACT [] +synonym: "dTDP-rhamnose biosynthesis" EXACT [] +synonym: "dTDP-rhamnose formation" EXACT [] +synonym: "dTDP-rhamnose synthesis" EXACT [] +xref: MetaCyc:DTDPRHAMSYN-PWY +xref: MetaCyc:PWY-3221 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019300 ! rhamnose biosynthetic process +is_a: GO:0046383 ! dTDP-rhamnose metabolic process + +[Term] +id: GO:0019306 +name: GDP-D-rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP-D-rhamnose anabolism" EXACT [] +synonym: "GDP-D-rhamnose biosynthesis" EXACT [] +synonym: "GDP-D-rhamnose formation" EXACT [] +synonym: "GDP-D-rhamnose synthesis" EXACT [] +xref: MetaCyc:GDPRHAMSYN-PWY +is_a: GO:0006002 ! fructose 6-phosphate metabolic process +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019300 ! rhamnose biosynthetic process +is_a: GO:0046382 ! GDP-D-rhamnose metabolic process + +[Term] +id: GO:0019307 +name: mannose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] +subset: gosubset_prok +synonym: "mannose anabolism" EXACT [] +synonym: "mannose biosynthesis" EXACT [] +synonym: "mannose formation" EXACT [] +synonym: "mannose synthesis" EXACT [] +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0019308 +name: dTDP-mannose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "dTDP-mannose anabolism" EXACT [] +synonym: "dTDP-mannose biosynthesis" EXACT [] +synonym: "dTDP-mannose formation" EXACT [] +synonym: "dTDP-mannose synthesis" EXACT [] +is_a: GO:0019307 ! mannose biosynthetic process +is_a: GO:0046371 ! dTDP-mannose metabolic process + +[Term] +id: GO:0019309 +name: mannose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] +subset: gosubset_prok +synonym: "mannose breakdown" EXACT [] +synonym: "mannose catabolism" EXACT [] +synonym: "mannose degradation" EXACT [] +xref: MetaCyc:MANNCAT-PWY +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019310 +name: inositol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, GOC:go_curators] +subset: gosubset_prok +synonym: "inositol breakdown" EXACT [] +synonym: "inositol catabolism" EXACT [] +synonym: "inositol degradation" EXACT [] +synonym: "myo-inositol catabolic process" NARROW [] +synonym: "myo-inositol catabolism" NARROW [] +synonym: "vitamin Bh catabolic process" EXACT [] +synonym: "vitamin Bh catabolism" EXACT [] +xref: MetaCyc:P562-PWY +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0046174 ! polyol catabolic process + +[Term] +id: GO:0019311 +name: sorbose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sorbose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0019312 +name: L-sorbose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sorbose, the levorotatory isomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-sorbose metabolism" EXACT [] +xref: MetaCyc:P302-PWY +is_a: GO:0019311 ! sorbose metabolic process + +[Term] +id: GO:0019313 +name: allose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "allose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0019314 +name: D-allose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-allose, the dextrorotatory isomer of D-allo-hexose, an aldohexose similar to glucose." [GOC:ai] +subset: gosubset_prok +synonym: "D-allose metabolism" EXACT [] +is_a: GO:0019313 ! allose metabolic process + +[Term] +id: GO:0019315 +name: D-allose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-allose, the dextrorotatory isomer of D-allo-hexose, an aldohexose similar to glucose." [GOC:ai] +subset: gosubset_prok +synonym: "D-allose anabolism" EXACT [] +synonym: "D-allose biosynthesis" EXACT [] +synonym: "D-allose formation" EXACT [] +synonym: "D-allose synthesis" EXACT [] +is_a: GO:0019314 ! D-allose metabolic process +is_a: GO:0046366 ! allose biosynthetic process + +[Term] +id: GO:0019316 +name: D-allose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the dextrorotatory isomer of D-allo-hexose, an aldohexose similar to glucose." [GOC:ai] +subset: gosubset_prok +synonym: "D-allose breakdown" EXACT [] +synonym: "D-allose catabolism" EXACT [] +synonym: "D-allose degradation" EXACT [] +xref: MetaCyc:PWY0-44 +is_a: GO:0019314 ! D-allose metabolic process +is_a: GO:0046367 ! allose catabolic process + +[Term] +id: GO:0019317 +name: fucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl] +subset: gosubset_prok +synonym: "fucose breakdown" EXACT [] +synonym: "fucose catabolism" EXACT [] +synonym: "fucose degradation" EXACT [] +xref: MetaCyc:FUCCAT-PWY +is_a: GO:0006004 ! fucose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019318 +name: hexose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hexose metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process + +[Term] +id: GO:0019319 +name: hexose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hexose anabolism" EXACT [] +synonym: "hexose biosynthesis" EXACT [] +synonym: "hexose formation" EXACT [] +synonym: "hexose synthesis" EXACT [] +is_a: GO:0019318 ! hexose metabolic process +is_a: GO:0046364 ! monosaccharide biosynthetic process + +[Term] +id: GO:0019320 +name: hexose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hexose breakdown" EXACT [] +synonym: "hexose catabolism" EXACT [] +synonym: "hexose degradation" EXACT [] +is_a: GO:0019318 ! hexose metabolic process +is_a: GO:0046365 ! monosaccharide catabolic process + +[Term] +id: GO:0019321 +name: pentose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentose metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process + +[Term] +id: GO:0019322 +name: pentose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentose anabolism" EXACT [] +synonym: "pentose biosynthesis" EXACT [] +synonym: "pentose formation" EXACT [] +synonym: "pentose synthesis" EXACT [] +is_a: GO:0019321 ! pentose metabolic process +is_a: GO:0046364 ! monosaccharide biosynthetic process + +[Term] +id: GO:0019323 +name: pentose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentose breakdown" EXACT [] +synonym: "pentose catabolism" EXACT [] +synonym: "pentose degradation" EXACT [] +is_a: GO:0019321 ! pentose metabolic process +is_a: GO:0046365 ! monosaccharide catabolic process + +[Term] +id: GO:0019324 +name: L-lyxose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-lyxose, the levorotatory isomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-lyxose metabolism" EXACT [] +xref: MetaCyc:LYXMET-PWY +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0019325 +name: anaerobic fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic fructose breakdown" EXACT [] +synonym: "anaerobic fructose catabolism" EXACT [] +synonym: "anaerobic fructose degradation" EXACT [] +xref: MetaCyc:ANAEROFRUCAT-PWY +is_a: GO:0006001 ! fructose catabolic process +is_a: GO:0019317 ! fucose catabolic process + +[Term] +id: GO:0019326 +name: nitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] +subset: gosubset_prok +synonym: "nitrotoluene metabolism" EXACT [] +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0019327 +name: oxidation of lead sulfide +namespace: biological_process +subset: gosubset_prok +synonym: "oxidation of galena" EXACT [] +synonym: "oxidation of lead sulphide" EXACT [] +xref: MetaCyc:P301-PWY +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019328 +name: anaerobic gallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "anaerobic gallate breakdown" EXACT [] +synonym: "anaerobic gallate catabolism" EXACT [] +synonym: "anaerobic gallate degradation" EXACT [] +synonym: "anaerobic gallic acid catabolic process" EXACT [] +synonym: "anaerobic gallic acid catabolism" EXACT [] +synonym: "gallate fermentation" EXACT [] +xref: MetaCyc:P3-PWY +is_a: GO:0019396 ! gallate catabolic process + +[Term] +id: GO:0019329 +name: ammonia oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:AMMOXID-PWY +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0019330 +name: aldoxime metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [http://cancerweb.ncl.ac.uk/] +synonym: "aldoxime metabolism" EXACT [] +xref: MetaCyc:P345-PWY +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0019331 +name: anaerobic respiration, using ammonium as electron donor +namespace: biological_process +def: "The oxidation of ammonium (NH4) to nitrogen (N2), using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY] +subset: gosubset_prok +synonym: "anaerobic ammonium oxidation" BROAD [] +synonym: "anammox" EXACT [] +xref: MetaCyc:P303-PWY +is_a: GO:0009061 ! anaerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0019329 ! ammonia oxidation + +[Term] +id: GO:0019332 +name: aerobic respiration, using nitrite as electron donor +namespace: biological_process +def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY] +subset: gosubset_prok +synonym: "nitrite oxidation" BROAD [] +xref: MetaCyc:P282-PWY +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0019333 +name: denitrification pathway +namespace: biological_process +def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY] +xref: MetaCyc:DENITRIFICATION-PWY +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0019334 +name: p-cymene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai] +subset: gosubset_prok +synonym: "p-cymene breakdown" EXACT [] +synonym: "p-cymene catabolism" EXACT [] +synonym: "p-cymene degradation" EXACT [] +xref: MetaCyc:PWY-741 +is_a: GO:0018953 ! p-cymene metabolic process +is_a: GO:0042203 ! toluene catabolic process + +[Term] +id: GO:0019335 +name: 3-methylquinoline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] +subset: gosubset_prok +synonym: "3-methylquinoline breakdown" EXACT [] +synonym: "3-methylquinoline catabolism" EXACT [] +synonym: "3-methylquinoline degradation" EXACT [] +xref: MetaCyc:PWY-721 +is_a: GO:0018930 ! 3-methylquinoline metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019336 +name: phenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carbolic acid catabolic process" EXACT [] +synonym: "carbolic acid catabolism" EXACT [] +synonym: "hydroxybenzene catabolic process" EXACT [] +synonym: "hydroxybenzene catabolism" EXACT [] +synonym: "phenol breakdown" EXACT [] +synonym: "phenol catabolism" EXACT [] +synonym: "phenol degradation" EXACT [] +xref: MetaCyc:PHENOLDEG-PWY +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0019337 +name: tetrachloroethylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai] +subset: gosubset_prok +synonym: "tetrachloroethene catabolic process" EXACT [] +synonym: "tetrachloroethene catabolism" EXACT [] +synonym: "tetrachloroethylene breakdown" EXACT [] +synonym: "tetrachloroethylene catabolism" EXACT [] +synonym: "tetrachloroethylene degradation" EXACT [] +xref: MetaCyc:PCEDEG-PWY +is_a: GO:0018967 ! tetrachloroethylene metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0019338 +name: pentachlorophenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators] +subset: gosubset_prok +synonym: "pentachlorophenol breakdown" EXACT [] +synonym: "pentachlorophenol catabolism" EXACT [] +synonym: "pentachlorophenol degradation" EXACT [] +xref: MetaCyc:PCPDEG-PWY +is_a: GO:0018961 ! pentachlorophenol metabolic process +is_a: GO:0019336 ! phenol catabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0019339 +name: parathion catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [http://umbbd.ahc.umn.edu/pthn/pthn_map.html, UM-BBD_pathwayID:pthn] +subset: gosubset_prok +synonym: "parathion breakdown" EXACT [] +synonym: "parathion catabolism" EXACT [] +synonym: "parathion degradation" EXACT [] +xref: MetaCyc:PARATHION-DEGRADATION-PWY +is_a: GO:0018952 ! parathion metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0019340 +name: dibenzofuran catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai] +subset: gosubset_prok +synonym: "dibenzofuran breakdown" EXACT [] +synonym: "dibenzofuran catabolism" EXACT [] +synonym: "dibenzofuran degradation" EXACT [] +xref: MetaCyc:P662-PWY +is_a: GO:0018893 ! dibenzofuran metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019341 +name: dibenzo-p-dioxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai] +subset: gosubset_prok +synonym: "dibenzo-p-dioxin breakdown" EXACT [] +synonym: "dibenzo-p-dioxin catabolism" EXACT [] +synonym: "dibenzo-p-dioxin degradation" EXACT [] +xref: MetaCyc:P661-PWY +is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019342 +name: trypanothione biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355] +subset: gosubset_prok +synonym: "trypanothione anabolism" EXACT [] +synonym: "trypanothione biosynthesis" EXACT [] +synonym: "trypanothione formation" EXACT [] +synonym: "trypanothione synthesis" EXACT [] +xref: MetaCyc:TRYPANOSYN-PWY +is_a: GO:0008295 ! spermidine biosynthetic process +is_a: GO:0046206 ! trypanothione metabolic process + +[Term] +id: GO:0019343 +name: cysteine biosynthetic process via cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators] +subset: gosubset_prok +synonym: "cysteine anabolism via cystathionine" EXACT [] +synonym: "cysteine formation via cystathionine" EXACT [] +synonym: "cysteine synthesis via cystathionine" EXACT [] +xref: MetaCyc:CYSTEINE-SYN2-PWY +is_a: GO:0019344 ! cysteine biosynthetic process + +[Term] +id: GO:0019344 +name: cysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "cysteine anabolism" EXACT [] +synonym: "cysteine biosynthesis" EXACT [] +synonym: "cysteine formation" EXACT [] +synonym: "cysteine synthesis" EXACT [] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process + +[Term] +id: GO:0019345 +name: cysteine biosynthetic process via S-sulfo-L-cysteine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators] +subset: gosubset_prok +synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT [] +synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT [] +synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT [] +synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT [] +synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT [] +xref: MetaCyc:CYSSERANA-PWY +is_a: GO:0019344 ! cysteine biosynthetic process + +[Term] +id: GO:0019346 +name: transsulfuration +namespace: biological_process +def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801] +subset: gosubset_prok +synonym: "homocysteine-cysteine interconversion" NARROW [] +synonym: "transsulphuration" EXACT [] +xref: MetaCyc:PWY-801 +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0009092 ! homoserine metabolic process + +[Term] +id: GO:0019347 +name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT [] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT [] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT [] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT [] +xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS +is_a: GO:0019408 ! dolichol biosynthetic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process + +[Term] +id: GO:0019348 +name: dolichol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dolichol metabolism" EXACT [] +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0019349 +name: ribitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribitol metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0019350 +name: teichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "teichoic acid anabolism" EXACT [] +synonym: "teichoic acid biosynthesis" EXACT [] +synonym: "teichoic acid formation" EXACT [] +synonym: "teichoic acid synthesis" EXACT [] +xref: MetaCyc:TEICHOICACID-PWY +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019349 ! ribitol metabolic process +is_a: GO:0046374 ! teichoic acid metabolic process +relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0019351 +name: dethiobiotin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "desthiobiotin biosynthesis" EXACT [] +synonym: "desthiobiotin biosynthetic process" EXACT [] +synonym: "dethiobiotin anabolism" EXACT [] +synonym: "dethiobiotin biosynthesis" EXACT [] +synonym: "dethiobiotin formation" EXACT [] +synonym: "dethiobiotin synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046450 ! dethiobiotin metabolic process +relationship: part_of GO:0009102 ! biotin biosynthetic process + +[Term] +id: GO:0019352 +name: protoporphyrinogen IX biosynthetic process from glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators] +subset: gosubset_prok +synonym: "protoporphyrinogen IX anabolism from glycine" EXACT [] +synonym: "protoporphyrinogen IX formation from glycine" EXACT [] +synonym: "protoporphyrinogen IX synthesis from glycine" EXACT [] +xref: MetaCyc:HEME+BIOSYNTHESIS+II +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process + +[Term] +id: GO:0019353 +name: protoporphyrinogen IX biosynthetic process from glutamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators] +subset: gosubset_prok +synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT [] +synonym: "protoporphyrinogen IX formation from glutamate" EXACT [] +synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT [] +xref: MetaCyc:HEME+BIOSYNTHESIS+II +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process + +[Term] +id: GO:0019354 +name: siroheme biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sirohaem biosynthesis" EXACT [] +synonym: "sirohaem biosynthetic process" EXACT [] +synonym: "siroheme anabolism" EXACT [] +synonym: "siroheme biosynthesis" EXACT [] +synonym: "siroheme formation" EXACT [] +synonym: "siroheme synthase activity" RELATED [] +synonym: "siroheme synthesis" EXACT [] +xref: AraCyc:PWYQT-62 +xref: MetaCyc:PWY-5194 +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046156 ! siroheme metabolic process + +[Term] +id: GO:0019355 +name: nicotinamide nucleotide biosynthetic process from aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators] +subset: gosubset_prok +synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT [] +synonym: "nicotinamide nucleotide formation from aspartate" EXACT [] +synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT [] +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process + +[Term] +id: GO:0019356 +name: nicotinate nucleotide biosynthetic process from tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators] +subset: gosubset_prok +synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT [] +synonym: "nicotinate nucleotide formation from tryptophan" EXACT [] +synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT [] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process + +[Term] +id: GO:0019357 +name: nicotinate nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators] +subset: gosubset_prok +synonym: "nicotinate nucleotide anabolism" EXACT [] +synonym: "nicotinate nucleotide biosynthesis" EXACT [] +synonym: "nicotinate nucleotide formation" EXACT [] +synonym: "nicotinate nucleotide synthesis" EXACT [] +is_a: GO:0046497 ! nicotinate nucleotide metabolic process + +[Term] +id: GO:0019358 +name: nicotinate nucleotide salvage +namespace: biological_process +def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators] +subset: gosubset_prok +synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT [] +synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT [] +xref: MetaCyc:NAD+BIOSYNTHESIS +xref: MetaCyc:NAD+BIOSYNTHESIS+II +xref: MetaCyc:PWY-5381 +xref: MetaCyc:PYRIDNUCSAL-PWY +is_a: GO:0019365 ! pyridine nucleotide salvage +is_a: GO:0046497 ! nicotinate nucleotide metabolic process + +[Term] +id: GO:0019359 +name: nicotinamide nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators] +subset: gosubset_prok +synonym: "nicotinamide nucleotide anabolism" EXACT [] +synonym: "nicotinamide nucleotide biosynthesis" EXACT [] +synonym: "nicotinamide nucleotide formation" EXACT [] +synonym: "nicotinamide nucleotide synthesis" EXACT [] +is_a: GO:0046496 ! nicotinamide nucleotide metabolic process + +[Term] +id: GO:0019360 +name: nicotinamide nucleotide biosynthetic process from niacinamide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators] +subset: gosubset_prok +synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT [] +synonym: "nicotinamide nucleotide formation from niacinamide" EXACT [] +synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT [] +xref: MetaCyc:NAD+BIOSYNTHESIS+III +is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process + +[Term] +id: GO:0019361 +name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] +subset: gosubset_prok +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT [] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT [] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT [] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT [] +xref: MetaCyc:P2-PWY +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process + +[Term] +id: GO:0019362 +name: pyridine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] +subset: gosubset_prok +synonym: "pyridine nucleotide metabolism" EXACT [] +is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0019363 +name: pyridine nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] +subset: gosubset_prok +synonym: "pyridine nucleotide anabolism" EXACT [] +synonym: "pyridine nucleotide biosynthesis" EXACT [] +synonym: "pyridine nucleotide formation" EXACT [] +synonym: "pyridine nucleotide synthesis" EXACT [] +xref: MetaCyc:PYRIDNUCSYN-PWY +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0019362 ! pyridine nucleotide metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process + +[Term] +id: GO:0019364 +name: pyridine nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] +subset: gosubset_prok +synonym: "pyridine nucleotide breakdown" EXACT [] +synonym: "pyridine nucleotide catabolism" EXACT [] +synonym: "pyridine nucleotide degradation" EXACT [] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0019362 ! pyridine nucleotide metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process + +[Term] +id: GO:0019365 +name: pyridine nucleotide salvage +namespace: biological_process +def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "pyridine nucleotide cycling" EXACT [] +is_a: GO:0019362 ! pyridine nucleotide metabolic process +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0019367 +name: fatty acid elongation, saturated fatty acid +namespace: biological_process +def: "Elongation of a saturated fatty acid chain." [GOC:mah] +subset: gosubset_prok +xref: MetaCyc:FASYN-ELONG-PWY +is_a: GO:0030497 ! fatty acid elongation + +[Term] +id: GO:0019368 +name: fatty acid elongation, unsaturated fatty acid +namespace: biological_process +def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] +subset: gosubset_prok +xref: MetaCyc:PWY0-862 +is_a: GO:0030497 ! fatty acid elongation + +[Term] +id: GO:0019369 +name: arachidonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "arachidonic acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0019370 +name: leukotriene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "leukotriene anabolism" EXACT [] +synonym: "leukotriene biosynthesis" EXACT [] +synonym: "leukotriene formation" EXACT [] +synonym: "leukotriene synthesis" EXACT [] +is_a: GO:0006691 ! leukotriene metabolic process +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:0046456 ! icosanoid biosynthetic process + +[Term] +id: GO:0019371 +name: cyclooxygenase pathway +namespace: biological_process +subset: gosubset_prok +is_a: GO:0019369 ! arachidonic acid metabolic process +relationship: part_of GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0019372 +name: lipoxygenase pathway +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:PWY-541 +is_a: GO:0019369 ! arachidonic acid metabolic process +relationship: part_of GO:0019370 ! leukotriene biosynthetic process + +[Term] +id: GO:0019373 +name: epoxygenase P450 pathway +namespace: biological_process +subset: gosubset_prok +is_a: GO:0019369 ! arachidonic acid metabolic process + +[Term] +id: GO:0019374 +name: galactolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactolipid metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process + +[Term] +id: GO:0019375 +name: galactolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactolipid anabolism" EXACT [] +synonym: "galactolipid biosynthesis" EXACT [] +synonym: "galactolipid formation" EXACT [] +synonym: "galactolipid synthesis" EXACT [] +xref: MetaCyc:LIPSYN-PWY +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0019374 ! galactolipid metabolic process + +[Term] +id: GO:0019376 +name: galactolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactolipid breakdown" EXACT [] +synonym: "galactolipid catabolism" EXACT [] +synonym: "galactolipid degradation" EXACT [] +is_a: GO:0019374 ! galactolipid metabolic process +is_a: GO:0019377 ! glycolipid catabolic process + +[Term] +id: GO:0019377 +name: glycolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycolipid breakdown" EXACT [] +synonym: "glycolipid catabolism" EXACT [] +synonym: "glycolipid degradation" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0046466 ! membrane lipid catabolic process + +[Term] +id: GO:0019378 +name: sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor +namespace: biological_process +def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by enzymes of the class EC:1.8.1.-." [GOC:jl] +subset: gosubset_prok +synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] +xref: MetaCyc:PWY-781 +is_a: GO:0000103 ! sulfate assimilation + +[Term] +id: GO:0019379 +name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) +namespace: biological_process +def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl] +subset: gosubset_prok +synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT [] +xref: MetaCyc:SO4ASSIM-PWY +is_a: GO:0000103 ! sulfate assimilation + +[Term] +id: GO:0019380 +name: 3-phenylpropionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "3-phenylpropionate breakdown" EXACT [] +synonym: "3-phenylpropionate catabolism" EXACT [] +synonym: "3-phenylpropionate degradation" EXACT [] +xref: MetaCyc:HCAMHPDEG-PWY +xref: MetaCyc:P281-PWY +is_a: GO:0018962 ! 3-phenylpropionate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019381 +name: atrazine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, http://umbbd.ahc.umn.edu/atr/atr_map.html, UM-BBD_pathwayID:atr] +subset: gosubset_prok +synonym: "atrazine breakdown" EXACT [] +synonym: "atrazine catabolism" EXACT [] +synonym: "atrazine degradation" EXACT [] +xref: MetaCyc:P141-PWY +is_a: GO:0018873 ! atrazine metabolic process +is_a: GO:0042204 ! s-triazine compound catabolic process + +[Term] +id: GO:0019382 +name: carbon tetrachloride catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators] +subset: gosubset_prok +synonym: "carbon tetrachloride breakdown" EXACT [] +synonym: "carbon tetrachloride catabolism" EXACT [] +synonym: "carbon tetrachloride degradation" EXACT [] +xref: MetaCyc:P582-PWY +is_a: GO:0018885 ! carbon tetrachloride metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0019383 +name: (+)-camphor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [http://umbbd.ahc.umn.edu/cam/cam_map.html, UM-BBD_pathwayID:cam] +subset: gosubset_prok +synonym: "(+)-camphor breakdown" EXACT [] +synonym: "(+)-camphor catabolism" EXACT [] +synonym: "(+)-camphor degradation" EXACT [] +xref: MetaCyc:P601-PWY +is_a: GO:0018882 ! (+)-camphor metabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0043694 ! monoterpene catabolic process + +[Term] +id: GO:0019384 +name: caprolactam catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "caprolactam breakdown" EXACT [] +synonym: "caprolactam catabolism" EXACT [] +synonym: "caprolactam degradation" EXACT [] +xref: MetaCyc:P621-PWY +is_a: GO:0018883 ! caprolactam metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019385 +name: methanogenesis, from acetate +namespace: biological_process +def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai] +subset: gosubset_prok +synonym: "methane biosynthesis from acetate" EXACT [] +synonym: "methane biosynthetic process from acetate" EXACT [] +xref: MetaCyc:METH-ACETATE-PWY +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:0019386 +name: methanogenesis, from carbon dioxide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai] +subset: gosubset_prok +synonym: "methane biosynthesis from carbon dioxide" EXACT [] +synonym: "methane biosynthetic process from carbon dioxide" EXACT [] +xref: MetaCyc:METHANOGENESIS-PWY +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:0019387 +name: methanogenesis, from methanol +namespace: biological_process +def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai] +subset: gosubset_prok +synonym: "methane biosynthesis from methanol" EXACT [] +synonym: "methane biosynthetic process from methanol" EXACT [] +xref: MetaCyc:METHFORM-PWY +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:0019388 +name: galactose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactose breakdown" EXACT [] +synonym: "galactose catabolism" EXACT [] +synonym: "galactose degradation" EXACT [] +xref: MetaCyc:GALDEG-PWY +xref: Reactome:211681 +xref: Reactome:221452 +xref: Reactome:230081 +xref: Reactome:238104 +xref: Reactome:244750 +xref: Reactome:249657 +xref: Reactome:252440 +xref: Reactome:255606 +xref: Reactome:258986 +xref: Reactome:262356 +xref: Reactome:265178 +xref: Reactome:268306 +xref: Reactome:274024 +xref: Reactome:280502 +xref: Reactome:282788 +xref: Reactome:286614 +xref: Reactome:291700 +xref: Reactome:292403 +xref: Reactome:293676 +xref: Reactome:70370 +is_a: GO:0006012 ! galactose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019389 +name: glucuronoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucuronide metabolic process" EXACT [] +synonym: "glucuronide metabolism" EXACT [] +synonym: "glucuronoside metabolism" EXACT [] +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0019390 +name: glucuronoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucuronide biosynthesis" EXACT [] +synonym: "glucuronide biosynthetic process" EXACT [] +synonym: "glucuronoside anabolism" EXACT [] +synonym: "glucuronoside biosynthesis" EXACT [] +synonym: "glucuronoside formation" EXACT [] +synonym: "glucuronoside synthesis" EXACT [] +is_a: GO:0019389 ! glucuronoside metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0019391 +name: glucuronoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucuronide catabolic process" EXACT [] +synonym: "glucuronide catabolism" EXACT [] +synonym: "glucuronoside breakdown" EXACT [] +synonym: "glucuronoside catabolism" EXACT [] +synonym: "glucuronoside degradation" EXACT [] +xref: MetaCyc:GLUCUROCAT-PWY +is_a: GO:0019389 ! glucuronoside metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0019392 +name: glucarate metabolic process +namespace: biological_process +alt_id: GO:0019581 +def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucarate metabolism" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process + +[Term] +id: GO:0019393 +name: glucarate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucarate anabolism" EXACT [] +synonym: "glucarate biosynthesis" EXACT [] +synonym: "glucarate formation" EXACT [] +synonym: "glucarate synthesis" EXACT [] +is_a: GO:0019392 ! glucarate metabolic process +is_a: GO:0019578 ! aldaric acid biosynthetic process + +[Term] +id: GO:0019394 +name: glucarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucarate breakdown" EXACT [] +synonym: "glucarate catabolism" EXACT [] +synonym: "glucarate degradation" EXACT [] +xref: MetaCyc:GLUCARDEG-PWY +is_a: GO:0019392 ! glucarate metabolic process +is_a: GO:0019579 ! aldaric acid catabolic process + +[Term] +id: GO:0019395 +name: fatty acid oxidation +namespace: biological_process +def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:FAO-PWY] +subset: gosubset_prok +xref: MetaCyc:FAO-PWY +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0034440 ! lipid oxidation + +[Term] +id: GO:0019396 +name: gallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl] +subset: gosubset_prok +synonym: "gallate breakdown" EXACT [] +synonym: "gallate catabolism" EXACT [] +synonym: "gallate degradation" EXACT [] +synonym: "gallic acid catabolic process" EXACT [] +synonym: "gallic acid catabolism" EXACT [] +is_a: GO:0018918 ! gallate metabolic process +is_a: GO:0019614 ! catechol catabolic process + +[Term] +id: GO:0019397 +name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl] +subset: gosubset_prok +synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT [] +synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT [] +synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT [] +synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT [] +xref: MetaCyc:GALLATE-DEGRADATION-I-PWY +is_a: GO:0042195 ! aerobic gallate catabolic process + +[Term] +id: GO:0019398 +name: gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 4-carboxy-2-hydroxhexa-2,3-dienedioate." [GOC:jl] +subset: gosubset_prok +synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +xref: MetaCyc:GALLATE-DEGRADATION-II-PWY +is_a: GO:0042195 ! aerobic gallate catabolic process + +[Term] +id: GO:0019399 +name: cyclohexanol oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY +is_a: GO:0018891 ! cyclohexanol metabolic process + +[Term] +id: GO:0019400 +name: alditol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alditol metabolism" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0019401 +name: alditol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alditol anabolism" EXACT [] +synonym: "alditol biosynthesis" EXACT [] +synonym: "alditol formation" EXACT [] +synonym: "alditol synthesis" EXACT [] +is_a: GO:0019400 ! alditol metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process + +[Term] +id: GO:0019402 +name: galactitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactitol metabolism" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process + +[Term] +id: GO:0019403 +name: galactitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactitol anabolism" EXACT [] +synonym: "galactitol biosynthesis" EXACT [] +synonym: "galactitol formation" EXACT [] +synonym: "galactitol synthesis" EXACT [] +is_a: GO:0019402 ! galactitol metabolic process +is_a: GO:0019406 ! hexitol biosynthetic process + +[Term] +id: GO:0019404 +name: galactitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactitol breakdown" EXACT [] +synonym: "galactitol catabolism" EXACT [] +synonym: "galactitol degradation" EXACT [] +xref: MetaCyc:GALACTITOLCAT-PWY +is_a: GO:0019402 ! galactitol metabolic process +is_a: GO:0019407 ! hexitol catabolic process + +[Term] +id: GO:0019405 +name: alditol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alditol breakdown" EXACT [] +synonym: "alditol catabolism" EXACT [] +synonym: "alditol degradation" EXACT [] +is_a: GO:0019400 ! alditol metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0046174 ! polyol catabolic process + +[Term] +id: GO:0019406 +name: hexitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hexitol anabolism" EXACT [] +synonym: "hexitol biosynthesis" EXACT [] +synonym: "hexitol formation" EXACT [] +synonym: "hexitol synthesis" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process +is_a: GO:0019401 ! alditol biosynthetic process + +[Term] +id: GO:0019407 +name: hexitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hexitol breakdown" EXACT [] +synonym: "hexitol catabolism" EXACT [] +synonym: "hexitol degradation" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process +is_a: GO:0019405 ! alditol catabolic process + +[Term] +id: GO:0019408 +name: dolichol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dolichol anabolism" EXACT [] +synonym: "dolichol biosynthesis" EXACT [] +synonym: "dolichol formation" EXACT [] +synonym: "dolichol synthesis" EXACT [] +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0019348 ! dolichol metabolic process + +[Term] +id: GO:0019409 +name: aerobic respiration, using ammonium as electron donor +namespace: biological_process +subset: gosubset_prok +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0019329 ! ammonia oxidation + +[Term] +id: GO:0019410 +name: aerobic respiration, using carbon monoxide as electron donor +namespace: biological_process +subset: gosubset_prok +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019411 +name: aerobic respiration, using ferrous ions as electron donor +namespace: biological_process +subset: gosubset_prok +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019412 +name: aerobic respiration, using hydrogen as electron donor +namespace: biological_process +def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY] +subset: gosubset_prok +synonym: "hydrogen oxidation" BROAD [] +xref: MetaCyc:P283-PWY +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019413 +name: acetate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "acetate anabolism" EXACT [] +synonym: "acetate biosynthesis" EXACT [] +synonym: "acetate formation" EXACT [] +synonym: "acetate synthesis" EXACT [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0019414 +name: aerobic respiration, using sulfur or sulfate as electron donor +namespace: biological_process +subset: gosubset_prok +synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT [] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019415 +name: acetate biosynthetic process from carbon monoxide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators] +subset: gosubset_prok +synonym: "acetate anabolism from carbon monoxide" EXACT [] +synonym: "acetate formation from carbon monoxide" EXACT [] +synonym: "acetate synthesis from carbon monoxide" EXACT [] +synonym: "carbon monoxide dehydrogenase pathway" EXACT [] +xref: MetaCyc:CODH-PWY +is_a: GO:0019413 ! acetate biosynthetic process + +[Term] +id: GO:0019416 +name: polythionate oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:THIOSULFOX-PWY +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0019417 +name: sulfur oxidation +namespace: biological_process +def: "The addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:SULFUROX-PWY] +subset: gosubset_prok +synonym: "sulphur oxidation" EXACT [] +xref: MetaCyc:SULFUROX-PWY +is_a: GO:0006791 ! sulfur utilization + +[Term] +id: GO:0019418 +name: sulfide oxidation +namespace: biological_process +subset: gosubset_prok +synonym: "sulphide oxidation" EXACT [] +xref: MetaCyc:P222-PWY +is_a: GO:0006791 ! sulfur utilization + +[Term] +id: GO:0019419 +name: sulfate reduction +namespace: biological_process +subset: gosubset_prok +synonym: "sulphate reduction" EXACT [] +is_a: GO:0006791 ! sulfur utilization + +[Term] +id: GO:0019420 +name: dissimilatory sulfate reduction +namespace: biological_process +def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY] +subset: gosubset_prok +synonym: "dissimilatory sulphate reduction" EXACT [] +xref: MetaCyc:DISSULFRED-PWY +is_a: GO:0019419 ! sulfate reduction + +[Term] +id: GO:0019421 +name: sulfate reduction, APS pathway +namespace: biological_process +def: "The reduction of sulfate and ATP to adenosine-phosphosulfate (APS) and pyrophosphate. The activated compound APS then participates in a variety of downstream reactions." [GOC:jl, MetaCyc:P202-PWY] +subset: gosubset_prok +synonym: "assimilatory sulfate reduction" EXACT [] +synonym: "assimilatory sulphate reduction" EXACT [] +synonym: "sulphate reduction, APS pathway" EXACT [] +xref: MetaCyc:P202-PWY +is_a: GO:0019419 ! sulfate reduction + +[Term] +id: GO:0019422 +name: disproportionation of elemental sulfur +namespace: biological_process +def: "The process by which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY] +subset: gosubset_prok +synonym: "disproportionation of elemental sulphur" EXACT [] +xref: MetaCyc:P203-PWY +is_a: GO:0006791 ! sulfur utilization + +[Term] +id: GO:0019423 +name: sulfur oxidation, ferric ion-dependent +namespace: biological_process +subset: gosubset_prok +synonym: "sulphur oxidation, ferric ion-dependent" EXACT [] +xref: MetaCyc:FESULFOX-PWY +is_a: GO:0019417 ! sulfur oxidation + +[Term] +id: GO:0019424 +name: sulfide oxidation, using siroheme sulfite reductase +namespace: biological_process +subset: gosubset_prok +synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT [] +synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT [] +xref: MetaCyc:P223-PWY +is_a: GO:0019418 ! sulfide oxidation + +[Term] +id: GO:0019425 +name: sulfur oxidation, using siroheme sulfite reductase +namespace: biological_process +subset: gosubset_prok +synonym: "sulfur oxidation, using sirohaem sulfite reductase" EXACT [] +synonym: "sulphur oxidation, using siroheme sulphite reductase" EXACT [] +xref: MetaCyc:P223-PWY +is_a: GO:0019417 ! sulfur oxidation + +[Term] +id: GO:0019426 +name: bisulfite reduction +namespace: biological_process +subset: gosubset_prok +synonym: "bisulphite reduction" EXACT [] +xref: MetaCyc:P224-PWY +is_a: GO:0006791 ! sulfur utilization + +[Term] +id: GO:0019427 +name: acetyl-CoA biosynthetic process from acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY] +subset: gosubset_prok +synonym: "acetate utilization" RELATED [] +synonym: "acetyl-CoA anabolism from acetate" EXACT [] +synonym: "acetyl-CoA formation from acetate" EXACT [] +synonym: "acetyl-CoA synthesis from acetate" EXACT [] +xref: MetaCyc:ACETATEUTIL-PWY +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0006085 ! acetyl-CoA biosynthetic process + +[Term] +id: GO:0019428 +name: allantoin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators] +subset: gosubset_prok +synonym: "allantoin anabolism" EXACT [] +synonym: "allantoin biosynthesis" EXACT [] +synonym: "allantoin formation" EXACT [] +synonym: "allantoin synthesis" EXACT [] +xref: MetaCyc:URSIN-PWY +is_a: GO:0000255 ! allantoin metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process + +[Term] +id: GO:0019429 +name: fluorene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:go_curators] +subset: gosubset_prok +synonym: "fluorene breakdown" EXACT [] +synonym: "fluorene catabolism" EXACT [] +synonym: "fluorene degradation" EXACT [] +xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY +is_a: GO:0018917 ! fluorene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0019430 +name: removal of superoxide radicals +namespace: biological_process +def: "Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "removal of O2-" EXACT [] +synonym: "removal of oxygen free radicals" EXACT [] +xref: MetaCyc:DETOX1-PWY +is_a: GO:0006801 ! superoxide metabolic process + +[Term] +id: GO:0019431 +name: acetyl-CoA biosynthetic process from ethanol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators] +subset: gosubset_prok +synonym: "acetyl-CoA anabolism from ethanol" EXACT [] +synonym: "acetyl-CoA formation from ethanol" EXACT [] +synonym: "acetyl-CoA synthesis from ethanol" EXACT [] +xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0006085 ! acetyl-CoA biosynthetic process + +[Term] +id: GO:0019432 +name: triacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of triacylglycerol, any triester of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "triacylglycerol anabolism" EXACT [] +synonym: "triacylglycerol biosynthesis" EXACT [] +synonym: "triacylglycerol formation" EXACT [] +synonym: "triacylglycerol synthesis" EXACT [] +synonym: "triglyceride biosynthesis" EXACT [] +synonym: "triglyceride biosynthetic process" EXACT [] +xref: MetaCyc:TRIGLSYN-PWY +is_a: GO:0006641 ! triacylglycerol metabolic process +is_a: GO:0046463 ! acylglycerol biosynthetic process + +[Term] +id: GO:0019433 +name: triacylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of triacylglycerol, any triester of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "triacylglycerol breakdown" EXACT [] +synonym: "triacylglycerol catabolism" EXACT [] +synonym: "triacylglycerol degradation" EXACT [] +synonym: "triglyceride catabolic process" EXACT [] +synonym: "triglyceride catabolism" EXACT [] +xref: MetaCyc:LIPAS-PWY +xref: Reactome:163560 +xref: Reactome:211549 +xref: Reactome:221326 +xref: Reactome:229994 +xref: Reactome:237983 +xref: Reactome:244602 +xref: Reactome:249545 +xref: Reactome:252356 +xref: Reactome:255529 +xref: Reactome:258883 +xref: Reactome:262278 +xref: Reactome:265110 +xref: Reactome:268233 +xref: Reactome:273937 +xref: Reactome:280416 +xref: Reactome:282760 +xref: Reactome:288218 +xref: Reactome:291668 +xref: Reactome:293639 +is_a: GO:0006641 ! triacylglycerol metabolic process +is_a: GO:0046464 ! acylglycerol catabolic process + +[Term] +id: GO:0019434 +name: sophorosyloxydocosanoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] +subset: gosubset_prok +synonym: "sophorosyloxydocosanoate metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process + +[Term] +id: GO:0019435 +name: sophorosyloxydocosanoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] +subset: gosubset_prok +synonym: "sophorosyloxydocosanoate anabolism" EXACT [] +synonym: "sophorosyloxydocosanoate biosynthesis" EXACT [] +synonym: "sophorosyloxydocosanoate formation" EXACT [] +synonym: "sophorosyloxydocosanoate synthesis" EXACT [] +xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY +is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process + +[Term] +id: GO:0019436 +name: sophorosyloxydocosanoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] +subset: gosubset_prok +synonym: "sophorosyloxydocosanoate breakdown" EXACT [] +synonym: "sophorosyloxydocosanoate catabolism" EXACT [] +synonym: "sophorosyloxydocosanoate degradation" EXACT [] +xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY +is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0019438 +name: aromatic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] +subset: gosubset_prok +synonym: "aromatic compound anabolism" EXACT [] +synonym: "aromatic compound biosynthesis" EXACT [] +synonym: "aromatic compound formation" EXACT [] +synonym: "aromatic compound synthesis" EXACT [] +synonym: "aromatic hydrocarbon biosynthesis" NARROW [] +synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0019439 +name: aromatic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] +subset: gosubset_prok +synonym: "aromatic compound breakdown" EXACT [] +synonym: "aromatic compound catabolism" EXACT [] +synonym: "aromatic compound degradation" EXACT [] +synonym: "aromatic hydrocarbon catabolic process" NARROW [] +synonym: "aromatic hydrocarbon catabolism" NARROW [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0019440 +name: tryptophan catabolic process to indole-3-acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "tryptophan breakdown to indole-3-acetate" EXACT [] +synonym: "tryptophan catabolic process to IAA" EXACT [] +synonym: "tryptophan catabolic process to indoleacetic acid" EXACT [] +synonym: "tryptophan catabolism to indoleacetic acid" EXACT [] +synonym: "tryptophan degradation to indole-3-acetate" EXACT [] +xref: MetaCyc:TRPIAACAT-PWY +is_a: GO:0006569 ! tryptophan catabolic process +is_a: GO:0009683 ! indoleacetic acid metabolic process + +[Term] +id: GO:0019441 +name: tryptophan catabolic process to kynurenine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators] +subset: gosubset_prok +synonym: "tryptophan breakdown to kynurenine" EXACT [] +synonym: "tryptophan degradation to kynurenine" EXACT [] +xref: MetaCyc:TRPKYNCAT-PWY +is_a: GO:0006569 ! tryptophan catabolic process + +[Term] +id: GO:0019442 +name: tryptophan catabolic process to acetyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators] +subset: gosubset_prok +synonym: "tryptophan breakdown to acetyl-CoA" EXACT [] +synonym: "tryptophan degradation to acetyl-CoA" EXACT [] +xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1 +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0006569 ! tryptophan catabolic process + +[Term] +id: GO:0019443 +name: tryptophan catabolic process, using tryptophanase +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl] +comment: This term was made obsolete because it refers to a one-step pathway. +synonym: "tryptophan breakdown, using tryptophanase" EXACT [] +synonym: "tryptophan degradation, using tryptophanase" EXACT [] +is_obsolete: true +replaced_by: GO:0006569 +replaced_by: GO:0009034 + +[Term] +id: GO:0019444 +name: tryptophan catabolic process to catechol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators] +subset: gosubset_prok +synonym: "tryptophan breakdown to catechol" EXACT [] +synonym: "tryptophan degradation to catechol" EXACT [] +xref: MetaCyc:TRPCAT-PWY +is_a: GO:0006569 ! tryptophan catabolic process +is_a: GO:0009712 ! catechol metabolic process + +[Term] +id: GO:0019445 +name: tyrosine catabolic process to fumarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "tyrosine breakdown to fumarate" EXACT [] +synonym: "tyrosine degradation to fumarate" EXACT [] +xref: MetaCyc:TYRFUMCAT-PWY +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0006572 ! tyrosine catabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019446 +name: tyrosine catabolic process to phosphoenolpyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT [] +synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT [] +xref: MetaCyc:TYROSINE-DEG1-PWY +is_a: GO:0006572 ! tyrosine catabolic process + +[Term] +id: GO:0019447 +name: D-cysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-cysteine breakdown" EXACT [] +synonym: "D-cysteine catabolism" EXACT [] +synonym: "D-cysteine degradation" EXACT [] +is_a: GO:0009093 ! cysteine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0046438 ! D-cysteine metabolic process + +[Term] +id: GO:0019448 +name: L-cysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the levorotatory isomer of 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-cysteine breakdown" EXACT [] +synonym: "L-cysteine catabolism" EXACT [] +synonym: "L-cysteine degradation" EXACT [] +is_a: GO:0009093 ! cysteine catabolic process +is_a: GO:0046439 ! L-cysteine metabolic process + +[Term] +id: GO:0019449 +name: L-cysteine catabolic process to hypotaurine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-cysteine breakdown to hypotaurine" EXACT [] +synonym: "L-cysteine degradation to hypotaurine" EXACT [] +xref: MetaCyc:CYSDEGRV-PWY +is_a: GO:0019448 ! L-cysteine catabolic process + +[Term] +id: GO:0019450 +name: L-cysteine catabolic process to pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-cysteine breakdown to pyruvate" EXACT [] +synonym: "L-cysteine degradation to pyruvate" EXACT [] +xref: MetaCyc:LCYSDEG-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0019448 ! L-cysteine catabolic process + +[Term] +id: GO:0019451 +name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl] +subset: gosubset_prok +synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT [] +synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT [] +xref: MetaCyc:CYSTEINE-DEG-PWY +is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate + +[Term] +id: GO:0019452 +name: L-cysteine catabolic process to taurine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-cysteine breakdown to taurine" EXACT [] +synonym: "L-cysteine degradation to taurine" EXACT [] +xref: MetaCyc:CYSDEGRVI-PWY +is_a: GO:0019448 ! L-cysteine catabolic process +is_a: GO:0019530 ! taurine metabolic process + +[Term] +id: GO:0019453 +name: L-cysteine catabolic process via cystine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-cysteine breakdown via cystine" EXACT [] +synonym: "L-cysteine degradation via cystine" EXACT [] +is_a: GO:0019448 ! L-cysteine catabolic process + +[Term] +id: GO:0019454 +name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4)." [GOC:jl] +subset: gosubset_prok +synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT [] +synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT [] +is_a: GO:0019453 ! L-cysteine catabolic process via cystine + +[Term] +id: GO:0019455 +name: L-cysteine catabolic process via cystine, using cystine reductase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6)." [GOC:jl] +subset: gosubset_prok +synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT [] +synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT [] +xref: MetaCyc:CYSTHIOCYS-PWY +is_a: GO:0019453 ! L-cysteine catabolic process via cystine + +[Term] +id: GO:0019456 +name: L-cysteine catabolic process via cystine, using cysteine transaminase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3)." [GOC:jl] +subset: gosubset_prok +synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT [] +synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT [] +is_a: GO:0019453 ! L-cysteine catabolic process via cystine + +[Term] +id: GO:0019457 +name: methionine catabolic process to succinyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine breakdown to succinyl-CoA" EXACT [] +synonym: "methionine degradation to succinyl-CoA" EXACT [] +xref: MetaCyc:METHIONINE-DEG1-PWY +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0009087 ! methionine catabolic process + +[Term] +id: GO:0019458 +name: methionine catabolic process via 2-oxobutanoate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators] +subset: gosubset_prok +synonym: "methionine breakdown via 2-oxobutanoate" EXACT [] +synonym: "methionine degradation via 2-oxobutanoate" EXACT [] +xref: MetaCyc:PWY-701 +is_a: GO:0009087 ! methionine catabolic process + +[Term] +id: GO:0019459 +name: glutamate deamidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:GLUTAMINDEG-PWY +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019460 +name: glutamate catabolic process to fumarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including fumarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown to fumarate" EXACT [] +synonym: "glutamate degradation to fumarate" EXACT [] +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019461 +name: glutamate catabolic process to fumarate, using glutamate synthase (NADPH) +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:jl] +subset: gosubset_prok +synonym: "glutamate breakdown to fumarate, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamate degradation to fumarate, using glutamate synthase (NADPH)" EXACT [] +xref: MetaCyc:GLUTAMINEFUM-PWY +is_a: GO:0019460 ! glutamate catabolic process to fumarate + +[Term] +id: GO:0019462 +name: glutamate catabolic process to fumarate, using glutaminase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:jl] +subset: gosubset_prok +synonym: "glutamate breakdown to fumarate, using glutaminase" EXACT [] +synonym: "glutamate degradation to fumarate, using glutaminase" EXACT [] +xref: MetaCyc:GLUTFUMARATE-PWY +is_a: GO:0019460 ! glutamate catabolic process to fumarate + +[Term] +id: GO:0019463 +name: glycine catabolic process to creatine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators] +subset: gosubset_prok +synonym: "glycine breakdown to creatine" EXACT [] +synonym: "glycine degradation to creatine" EXACT [] +xref: MetaCyc:GLYCGREAT-PWY +is_a: GO:0006546 ! glycine catabolic process +is_a: GO:0006600 ! creatine metabolic process + +[Term] +id: GO:0019464 +name: glycine decarboxylation via glycine cleavage system +namespace: biological_process +subset: gosubset_prok +synonym: "glycine cleavage system" BROAD [] +xref: MetaCyc:GLYCCAT-PWY +xref: MetaCyc:GLYCDEGRIII-PWY +xref: MetaCyc:GLYCINE-DEG1-PWY +xref: MetaCyc:GLYCLEAV-PWY +is_a: GO:0006546 ! glycine catabolic process + +[Term] +id: GO:0019465 +name: aspartate transamidation +namespace: biological_process +def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: MetaCyc:ASPARTATE-DEG1-PWY +xref: MetaCyc:ASPARTATESYN-PWY +is_a: GO:0006533 ! aspartate catabolic process + +[Term] +id: GO:0019466 +name: ornithine catabolic process via proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators] +subset: gosubset_prok +synonym: "ornithine breakdown via proline" EXACT [] +synonym: "ornithine degradation via proline" EXACT [] +xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:0019467 +name: ornithine catabolic process, by decarboxylation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators] +subset: gosubset_prok +synonym: "ornithine breakdown, by decarboxylation" EXACT [] +synonym: "ornithine degradation, by decarboxylation" EXACT [] +xref: MetaCyc:ORNDEG-PWY +is_a: GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:0019468 +name: nopaline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nopaline breakdown" EXACT [] +synonym: "nopaline catabolism" EXACT [] +synonym: "nopaline degradation" EXACT [] +xref: MetaCyc:NOPALINEDEG-PWY +is_a: GO:0042219 ! amino acid derivative catabolic process +is_a: GO:0046418 ! nopaline metabolic process + +[Term] +id: GO:0019469 +name: octopine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "octopine breakdown" EXACT [] +synonym: "octopine catabolism" EXACT [] +synonym: "octopine degradation" EXACT [] +xref: MetaCyc:OCTOPINEDEG-PWY +is_a: GO:0042219 ! amino acid derivative catabolic process +is_a: GO:0046419 ! octopine metabolic process + +[Term] +id: GO:0019470 +name: 4-hydroxyproline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] +subset: gosubset_prok +synonym: "4-hydroxyproline breakdown" EXACT [] +synonym: "4-hydroxyproline catabolism" EXACT [] +synonym: "4-hydroxyproline degradation" EXACT [] +xref: MetaCyc:HYDROXYPRODEG-PWY +is_a: GO:0009310 ! amine catabolic process +is_a: GO:0019471 ! 4-hydroxyproline metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0019471 +name: 4-hydroxyproline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "4-hydroxyproline metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0019472 +name: 4-hydroxyproline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] +subset: gosubset_prok +synonym: "4-hydroxyproline anabolism" EXACT [] +synonym: "4-hydroxyproline biosynthesis" EXACT [] +synonym: "4-hydroxyproline formation" EXACT [] +synonym: "4-hydroxyproline synthesis" EXACT [] +is_a: GO:0009309 ! amine biosynthetic process +is_a: GO:0019471 ! 4-hydroxyproline metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0019473 +name: L-lysine catabolic process to glutarate, by acetylation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT [] +synonym: "L-lysine degradation to glutarate, by acetylation" EXACT [] +xref: MetaCyc:LYSDEGII-PWY +is_a: GO:0019477 ! L-lysine catabolic process + +[Term] +id: GO:0019474 +name: L-lysine catabolic process to acetyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-lysine breakdown to acetyl-CoA" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0019477 ! L-lysine catabolic process + +[Term] +id: GO:0019475 +name: L-lysine catabolic process to acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-lysine breakdown to acetate" EXACT [] +synonym: "L-lysine degradation to acetate" EXACT [] +synonym: "lysine fermentation" EXACT [] +xref: MetaCyc:P163-PWY +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0019477 ! L-lysine catabolic process +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019476 +name: D-lysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the dextrorotatory isomer of (S)-2,6-diaminohexanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "D-lysine breakdown" EXACT [] +synonym: "D-lysine catabolism" EXACT [] +synonym: "D-lysine degradation" EXACT [] +xref: MetaCyc:DLYSCAT-PWY +is_a: GO:0006554 ! lysine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0046441 ! D-lysine metabolic process + +[Term] +id: GO:0019477 +name: L-lysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the levorotatory isomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-lysine breakdown" EXACT [] +synonym: "L-lysine catabolism" EXACT [] +synonym: "L-lysine degradation" EXACT [] +is_a: GO:0006554 ! lysine catabolic process +is_a: GO:0046440 ! L-lysine metabolic process + +[Term] +id: GO:0019478 +name: D-amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the dextrorotatory isomer of amino acids." [GOC:ai] +subset: gosubset_prok +synonym: "D-amino acid breakdown" EXACT [] +synonym: "D-amino acid catabolism" EXACT [] +synonym: "D-amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0019479 +name: L-alanine oxidation to propanoate +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:ALACAT2-PWY +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019480 +name: L-alanine oxidation to pyruvate via D-alanine +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:ALADEG-PWY +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019481 +name: L-alanine catabolic process, by transamination +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-alanine breakdown, by transamination" EXACT [] +synonym: "L-alanine degradation, by transamination" EXACT [] +xref: MetaCyc:ALANINE-DEG3-PWY +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019482 +name: beta-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-alanine metabolism" EXACT [] +is_a: GO:0019794 ! nonprotein amino acid metabolic process + +[Term] +id: GO:0019483 +name: beta-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-alanine anabolism" EXACT [] +synonym: "beta-alanine biosynthesis" EXACT [] +synonym: "beta-alanine formation" EXACT [] +synonym: "beta-alanine synthesis" EXACT [] +is_a: GO:0019482 ! beta-alanine metabolic process +is_a: GO:0019795 ! nonprotein amino acid biosynthetic process + +[Term] +id: GO:0019484 +name: beta-alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-alanine breakdown" EXACT [] +synonym: "beta-alanine catabolism" EXACT [] +synonym: "beta-alanine degradation" EXACT [] +is_a: GO:0019482 ! beta-alanine metabolic process +is_a: GO:0019796 ! nonprotein amino acid catabolic process + +[Term] +id: GO:0019485 +name: beta-alanine catabolic process to L-alanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators] +subset: gosubset_prok +synonym: "beta-alanine breakdown to L-alanine" EXACT [] +synonym: "beta-alanine degradation to L-alanine" EXACT [] +xref: MetaCyc:BETALANDEGII +is_a: GO:0019484 ! beta-alanine catabolic process +is_a: GO:0042851 ! L-alanine metabolic process + +[Term] +id: GO:0019486 +name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators] +subset: gosubset_prok +synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT [] +synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT [] +xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY +is_a: GO:0019484 ! beta-alanine catabolic process + +[Term] +id: GO:0019487 +name: anaerobic acetylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "anaerobic acetylene breakdown" EXACT [] +synonym: "anaerobic acetylene catabolism" EXACT [] +synonym: "anaerobic acetylene degradation" EXACT [] +synonym: "anaerobic ethyne catabolic process" EXACT [] +synonym: "anaerobic ethyne catabolism" EXACT [] +xref: MetaCyc:P161-PWY +is_a: GO:0018864 ! acetylene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043454 ! alkyne catabolic process + +[Term] +id: GO:0019488 +name: ribitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY] +subset: gosubset_prok +synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "ribitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "ribitol utilization" RELATED [] +xref: MetaCyc:RIBITOLUTIL-PWY +is_a: GO:0046363 ! ribitol catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019489 +name: methylgallate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] +subset: gosubset_prok +synonym: "methylgallate metabolism" EXACT [] +is_a: GO:0018918 ! gallate metabolic process + +[Term] +id: GO:0019490 +name: 2-aminobenzenesulfonate desulfonation +namespace: biological_process +def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [http://umbbd.ahc.umn.edu/abs/abs_map.html, UM-BBD_pathwayID:abs] +subset: gosubset_prok +synonym: "2-aminobenzenesulphonate desulphonation" EXACT [] +xref: MetaCyc:2ASDEG-PWY +is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process + +[Term] +id: GO:0019491 +name: ectoine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] +subset: gosubset_prok +synonym: "ectoine anabolism" EXACT [] +synonym: "ectoine biosynthesis" EXACT [] +synonym: "ectoine formation" EXACT [] +synonym: "ectoine synthesis" EXACT [] +xref: MetaCyc:P101-PWY +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042399 ! ectoine metabolic process + +[Term] +id: GO:0019492 +name: proline salvage +namespace: biological_process +def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "proline cycling" EXACT [] +xref: MetaCyc:PROLCAT-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0043102 ! amino acid salvage + +[Term] +id: GO:0019493 +name: arginine catabolic process to proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators] +subset: gosubset_prok +synonym: "arginine breakdown to proline" EXACT [] +synonym: "arginine degradation to proline" EXACT [] +xref: MetaCyc:ARG-PRO-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0006560 ! proline metabolic process + +[Term] +id: GO:0019494 +name: proline oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:PROUT-PWY +is_a: GO:0006560 ! proline metabolic process + +[Term] +id: GO:0019495 +name: proline catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "proline breakdown to 2-oxoglutarate" EXACT [] +synonym: "proline catabolic process to 2-ketoglutarate" EXACT [] +synonym: "proline catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "proline catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "proline catabolism to 2-ketoglutarate" EXACT [] +synonym: "proline catabolism to alpha-ketoglutarate" EXACT [] +synonym: "proline catabolism to alpha-oxoglutarate" EXACT [] +synonym: "proline degradation to 2-oxoglutarate" EXACT [] +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006562 ! proline catabolic process + +[Term] +id: GO:0019496 +name: serine-isocitrate lyase pathway +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:P106-PWY +is_a: GO:0006730 ! one-carbon compound metabolic process + +[Term] +id: GO:0019497 +name: hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch] +subset: gosubset_prok +synonym: "hexachlorocyclohexane metabolism" EXACT [] +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0019498 +name: n-octane oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:P221-PWY +is_a: GO:0018939 ! n-octane metabolic process + +[Term] +id: GO:0019499 +name: cyanide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanide metabolism" EXACT [] +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0019500 +name: cyanide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanide breakdown" EXACT [] +synonym: "cyanide catabolism" EXACT [] +synonym: "cyanide degradation" EXACT [] +xref: MetaCyc:P401-PWY +is_a: GO:0019499 ! cyanide metabolic process +is_a: GO:0019754 ! one-carbon compound catabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0019501 +name: arsonoacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl] +subset: gosubset_prok +synonym: "arsonoacetate breakdown" EXACT [] +synonym: "arsonoacetate catabolism" EXACT [] +synonym: "arsonoacetate degradation" EXACT [] +xref: MetaCyc:P482-PWY +is_a: GO:0018872 ! arsonoacetate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019502 +name: stachydrine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "stachydrine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0019503 +name: stachydrine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] +subset: gosubset_prok +synonym: "stachydrine anabolism" EXACT [] +synonym: "stachydrine biosynthesis" EXACT [] +synonym: "stachydrine formation" EXACT [] +synonym: "stachydrine synthesis" EXACT [] +is_a: GO:0019502 ! stachydrine metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0019504 +name: stachydrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] +subset: gosubset_prok +synonym: "stachydrine breakdown" EXACT [] +synonym: "stachydrine catabolism" EXACT [] +synonym: "stachydrine degradation" EXACT [] +xref: MetaCyc:P561-PWY +is_a: GO:0019502 ! stachydrine metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0019505 +name: resorcinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm] +subset: gosubset_prok +synonym: "1,3-benzenediol metabolic process" EXACT [] +synonym: "1,3-benzenediol metabolism" EXACT [] +synonym: "1,3-dihydroxybenzene metabolic process" EXACT [] +synonym: "1,3-dihydroxybenzene metabolism" EXACT [] +synonym: "resorcinol metabolism" EXACT [] +xref: MetaCyc:P343-PWY +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0019506 +name: phenylmercury acetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] +subset: gosubset_prok +synonym: "phenylmercury acetate breakdown" EXACT [] +synonym: "phenylmercury acetate catabolism" EXACT [] +synonym: "phenylmercury acetate degradation" EXACT [] +xref: MetaCyc:P641-PWY +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046412 ! phenylmercury acetate metabolic process +is_a: GO:0046413 ! organomercury catabolic process + +[Term] +id: GO:0019507 +name: pyridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "pyridine metabolism" EXACT [] +xref: Reactome:209614 +xref: Reactome:219352 +xref: Reactome:228159 +xref: Reactome:236372 +xref: Reactome:243501 +xref: Reactome:248582 +xref: Reactome:76517 +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0019508 +name: 2,5-dihydroxypyridine catabolic process to fumarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722] +subset: gosubset_prok +synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT [] +synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT [] +synonym: "2,5-dihydroxypyridine utilization" RELATED [] +synonym: "maleamate pathway" EXACT [] +xref: MetaCyc:PWY-722 +is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process + +[Term] +id: GO:0019509 +name: methionine salvage +namespace: biological_process +def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:P182-PWY] +subset: gosubset_prok +synonym: "methionine recycling" NARROW [] +synonym: "methionine regeneration" NARROW [] +synonym: "methionine salvage pathway" EXACT [] +xref: MetaCyc:PWY-4361 +is_a: GO:0006555 ! methionine metabolic process +is_a: GO:0043102 ! amino acid salvage + +[Term] +id: GO:0019510 +name: S-adenosylhomocysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-adenosylhomocysteine breakdown" EXACT [] +synonym: "S-adenosylhomocysteine catabolism" EXACT [] +synonym: "S-adenosylhomocysteine degradation" EXACT [] +xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process + +[Term] +id: GO:0019511 +name: peptidyl-proline hydroxylation +namespace: biological_process +alt_id: GO:0006472 +subset: gosubset_prok +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0019512 +name: lactose catabolic process via tagatose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactose breakdown via tagatose-6-phosphate" EXACT [] +synonym: "lactose degradation via tagatose-6-phosphate" EXACT [] +xref: MetaCyc:LACTOSECAT-PWY +is_a: GO:0005990 ! lactose catabolic process + +[Term] +id: GO:0019513 +name: lactose catabolic process, using glucoside 3-dehydrogenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl] +subset: gosubset_prok +synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT [] +synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT [] +xref: MetaCyc:LACTOSEUTIL-PWY +is_a: GO:0005990 ! lactose catabolic process + +[Term] +id: GO:0019514 +name: lactose hydrolysis +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because hydrolysis is a reaction. +is_obsolete: true +consider: GO:0004565 + +[Term] +id: GO:0019515 +name: lactose catabolic process via UDP-galactose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators] +subset: gosubset_prok +synonym: "lactose breakdown via UDP-galactose" EXACT [] +synonym: "lactose degradation via UDP-galactose" EXACT [] +xref: MetaCyc:LACTOSEDEG-PWY +is_a: GO:0005990 ! lactose catabolic process + +[Term] +id: GO:0019516 +name: lactate oxidation +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:LCTACACAT-PWY +is_a: GO:0006089 ! lactate metabolic process + +[Term] +id: GO:0019517 +name: threonine catabolic process to D-lactate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound D-lactate." [GOC:jl] +subset: gosubset_prok +synonym: "threonine breakdown to D-lactate" EXACT [] +synonym: "threonine degradation to D-lactate" EXACT [] +xref: MetaCyc:THRDLCTCAT-PWY +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0006567 ! threonine catabolic process + +[Term] +id: GO:0019518 +name: threonine catabolic process to pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound pyruvate." [GOC:jl] +subset: gosubset_prok +synonym: "threonine breakdown to pyruvate" EXACT [] +synonym: "threonine degradation to pyruvate" EXACT [] +xref: MetaCyc:THREONINE-DEG2-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0006567 ! threonine catabolic process + +[Term] +id: GO:0019519 +name: pentitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentitol metabolism" EXACT [] +is_a: GO:0019400 ! alditol metabolic process + +[Term] +id: GO:0019520 +name: aldonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aldonic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0019521 +name: D-gluconate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-gluconate metabolism" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019522 +name: ketogluconate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ketogluconate metabolism" EXACT [] +xref: MetaCyc:KETOGLUCONMET-PWY +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019523 +name: L-idonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "L-idonate metabolism" EXACT [] +xref: MetaCyc:IDNCAT-PWY +is_a: GO:0019522 ! ketogluconate metabolic process + +[Term] +id: GO:0019524 +name: D-dehydro-D-gluconate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-dehydro-D-gluconate breakdown" EXACT [] +synonym: "D-dehydro-D-gluconate catabolism" EXACT [] +synonym: "D-dehydro-D-gluconate degradation" EXACT [] +xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY +is_a: GO:0019525 ! D-dehydro-D-gluconate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0019525 +name: D-dehydro-D-gluconate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-dehydro-D-gluconate metabolism" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019526 +name: pentitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentitol anabolism" EXACT [] +synonym: "pentitol biosynthesis" EXACT [] +synonym: "pentitol formation" EXACT [] +synonym: "pentitol synthesis" EXACT [] +is_a: GO:0019401 ! alditol biosynthetic process +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0019527 +name: pentitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentitol breakdown" EXACT [] +synonym: "pentitol catabolism" EXACT [] +synonym: "pentitol degradation" EXACT [] +is_a: GO:0019405 ! alditol catabolic process +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0019528 +name: D-arabitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY] +subset: gosubset_prok +synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "D-arabitol degradation" RELATED [] +synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "D-arabitol utilization" RELATED [] +xref: MetaCyc:DARABITOLUTIL-PWY +is_a: GO:0051159 ! D-arabitol catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019529 +name: taurine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] +subset: gosubset_prok +synonym: "taurine breakdown" EXACT [] +synonym: "taurine catabolism" EXACT [] +synonym: "taurine degradation" EXACT [] +xref: MetaCyc:TAURINEDEG-PWY +is_a: GO:0019530 ! taurine metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0019530 +name: taurine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] +subset: gosubset_prok +synonym: "taurine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0019531 +name: oxalate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "oxalic acid transporter" EXACT [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0019532 +name: oxalate transport +namespace: biological_process +def: "The directed movement of oxalate into, out of, within or between cells. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ethanedioate transport" EXACT [] +synonym: "ethanedioic acid transport" EXACT [] +synonym: "oxalic acid transport" EXACT [] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0019533 +name: cellobiose transport +namespace: biological_process +def: "The directed movement of cellobiose into, out of, within or between cells. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0019534 +name: toxin transporter activity +namespace: molecular_function +def: "Enables the directed movement of a toxin into, out of, within or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0019535 +name: ferric-vibriobactin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity + +[Term] +id: GO:0019536 +name: vibriobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] +subset: gosubset_prok +synonym: "vibriobactin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0019537 +name: vibriobactin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] +subset: gosubset_prok +synonym: "vibriobactin anabolism" EXACT [] +synonym: "vibriobactin biosynthesis" EXACT [] +synonym: "vibriobactin formation" EXACT [] +synonym: "vibriobactin synthesis" EXACT [] +is_a: GO:0019536 ! vibriobactin metabolic process +is_a: GO:0019540 ! siderophore biosynthetic process from catechol + +[Term] +id: GO:0019538 +name: protein metabolic process +namespace: biological_process +alt_id: GO:0006411 +def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "protein metabolic process and modification" EXACT [] +synonym: "protein metabolism" EXACT [] +synonym: "protein metabolism and modification" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044238 ! primary metabolic process + +[Term] +id: GO:0019539 +name: siderophore biosynthetic process from hydroxamic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "siderochrome biosynthesis from hydroxamic acid" NARROW [] +synonym: "siderochrome biosynthetic process from hydroxamic acid" NARROW [] +synonym: "siderophore anabolism from hydroxamic acid" EXACT [] +synonym: "siderophore formation from hydroxamic acid" EXACT [] +synonym: "siderophore synthesis from hydroxamic acid" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0019540 +name: siderophore biosynthetic process from catechol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol." [GOC:go_curators] +subset: gosubset_prok +synonym: "siderochrome biosynthesis from catechol" NARROW [] +synonym: "siderochrome biosynthetic process from catechol" NARROW [] +synonym: "siderophore anabolism from catechol" EXACT [] +synonym: "siderophore formation from catechol" EXACT [] +synonym: "siderophore synthesis from catechol" EXACT [] +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0019541 +name: propionate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "propionate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019542 +name: propionate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "propionate anabolism" EXACT [] +synonym: "propionate biosynthesis" EXACT [] +synonym: "propionate formation" EXACT [] +synonym: "propionate synthesis" EXACT [] +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0019543 +name: propionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "propionate breakdown" EXACT [] +synonym: "propionate catabolism" EXACT [] +synonym: "propionate degradation" EXACT [] +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0019544 +name: arginine catabolic process to glutamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators] +subset: gosubset_prok +synonym: "arginine breakdown to glutamate" EXACT [] +synonym: "arginine degradation to glutamate" EXACT [] +xref: MetaCyc:ARG-GLU-PWY +xref: MetaCyc:ARGASEDEG-PWY +xref: MetaCyc:ARGININE-DEG1-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0006536 ! glutamate metabolic process + +[Term] +id: GO:0019545 +name: arginine catabolic process to succinate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators] +subset: gosubset_prok +synonym: "arginine breakdown to succinate" EXACT [] +synonym: "arginine degradation to succinate" EXACT [] +xref: MetaCyc:ARGDEG-II-PWY +xref: MetaCyc:ARGDEG-III-PWY +xref: MetaCyc:ARGDEG-IV-PWY +xref: MetaCyc:ARGDEG-V-PWY +xref: MetaCyc:AST-PWY +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0019546 +name: arginine deiminase pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY] +subset: gosubset_prok +xref: MetaCyc:ARGDEGRAD-PWY +is_a: GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0019547 +name: arginine catabolic process to ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators] +subset: gosubset_prok +synonym: "arginine breakdown to ornithine" EXACT [] +synonym: "arginine degradation to ornithine" EXACT [] +xref: MetaCyc:ARGORNCAT-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0019548 +name: arginine catabolic process to spermine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators] +subset: gosubset_prok +synonym: "arginine breakdown to spermine" EXACT [] +synonym: "arginine degradation to spermine" EXACT [] +xref: MetaCyc:ARGSPECAT-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0008215 ! spermine metabolic process + +[Term] +id: GO:0019549 +name: glutamate catabolic process to succinate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including succinate." [GOC:go_curators, MetaCyc:PWY-4321] +subset: gosubset_prok +synonym: "glutamate breakdown to succinate" EXACT [] +synonym: "glutamate degradation to succinate" EXACT [] +xref: MetaCyc:PWY-4321 +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019550 +name: glutamate catabolic process to aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown to aspartate" EXACT [] +synonym: "glutamate degradation to aspartate" EXACT [] +xref: MetaCyc:GLUTDEG-PWY +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019551 +name: glutamate catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown to 2-oxoglutarate" EXACT [] +synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "glutamate catabolism to 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT [] +synonym: "glutamate degradation to 2-oxoglutarate" EXACT [] +xref: MetaCyc:GLUTAMATE-DEG1-PWY +xref: MetaCyc:GLUTFUM-PWY +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019552 +name: glutamate catabolic process via 2-hydroxyglutarate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY] +subset: gosubset_prok +synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT [] +xref: MetaCyc:P162-PWY +is_a: GO:0019670 ! anaerobic glutamate catabolic process + +[Term] +id: GO:0019553 +name: glutamate catabolic process via L-citramalate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown via L-citramalate" EXACT [] +synonym: "glutamate degradation via L-citramalate" EXACT [] +xref: MetaCyc:GLUDEG-II-PWY +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019554 +name: glutamate catabolic process to oxaloacetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown to oxaloacetate" EXACT [] +synonym: "glutamate degradation to oxaloacetate" EXACT [] +xref: MetaCyc:GLUTOXA-PWY +is_a: GO:0006107 ! oxaloacetate metabolic process +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019555 +name: glutamate catabolic process to ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutamate breakdown to ornithine" EXACT [] +synonym: "glutamate degradation to ornithine" EXACT [] +xref: MetaCyc:GLUTORN-PWY +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0019556 +name: histidine catabolic process to glutamate and formamide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine breakdown to glutamate and formamide" EXACT [] +synonym: "histidine degradation to glutamate and formamide" EXACT [] +xref: MetaCyc:HISDEG-PWY +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006548 ! histidine catabolic process + +[Term] +id: GO:0019557 +name: histidine catabolic process to glutamate and formate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine breakdown to glutamate and formate" EXACT [] +synonym: "histidine degradation to glutamate and formate" EXACT [] +xref: MetaCyc:HISDEG-II-PWY +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006548 ! histidine catabolic process +is_a: GO:0015942 ! formate metabolic process + +[Term] +id: GO:0019558 +name: histidine catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine breakdown to 2-oxoglutarate" EXACT [] +synonym: "histidine catabolic process to 2-ketoglutarate" EXACT [] +synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "histidine catabolism to 2-ketoglutarate" EXACT [] +synonym: "histidine catabolism to alpha-ketoglutarate" EXACT [] +synonym: "histidine catabolism to alpha-oxoglutarate" EXACT [] +synonym: "histidine degradation to 2-oxoglutarate" EXACT [] +xref: MetaCyc:HISTIDINE-DEG1-PWY +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006548 ! histidine catabolic process + +[Term] +id: GO:0019559 +name: histidine catabolic process to imidazol-5-yl-lactate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT [] +synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT [] +xref: MetaCyc:HISTDEG-PWY +is_a: GO:0006548 ! histidine catabolic process + +[Term] +id: GO:0019560 +name: histidine catabolic process to hydantoin-5-propionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators] +subset: gosubset_prok +synonym: "histidine breakdown to hydantoin-5-propionate" EXACT [] +synonym: "histidine degradation to hydantoin-5-propionate" EXACT [] +xref: MetaCyc:HISHP-PWY +is_a: GO:0006548 ! histidine catabolic process + +[Term] +id: GO:0019561 +name: anaerobic phenylalanine oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY] +subset: gosubset_prok +xref: MetaCyc:ANAPHENOXI-PWY +is_a: GO:0006559 ! L-phenylalanine catabolic process + +[Term] +id: GO:0019562 +name: phenylalanine catabolic process to phosphoenolpyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT [] +synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT [] +xref: MetaCyc:PHENYLALANINE-DEG1-PWY +is_a: GO:0006559 ! L-phenylalanine catabolic process + +[Term] +id: GO:0019563 +name: glycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerol breakdown" EXACT [] +synonym: "glycerol catabolism" EXACT [] +synonym: "glycerol degradation" EXACT [] +xref: MetaCyc:PWY-4261 +xref: MetaCyc:PWY0-381 +is_a: GO:0006071 ! glycerol metabolic process +is_a: GO:0046174 ! polyol catabolic process + +[Term] +id: GO:0019564 +name: aerobic glycerol catabolic process +namespace: biological_process +alt_id: GO:0019565 +def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aerobic glycerol breakdown" EXACT [] +synonym: "aerobic glycerol catabolism" EXACT [] +synonym: "aerobic glycerol degradation" EXACT [] +synonym: "aerobic glycerol fermentation" RELATED [] +xref: MetaCyc:AERO-GLYCEROL-CAT-PWY +xref: MetaCyc:PWY0-381 +is_a: GO:0019563 ! glycerol catabolic process + +[Term] +id: GO:0019566 +name: arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "arabinose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0019567 +name: arabinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai] +subset: gosubset_prok +synonym: "arabinose anabolism" EXACT [] +synonym: "arabinose biosynthesis" EXACT [] +synonym: "arabinose formation" EXACT [] +synonym: "arabinose synthesis" EXACT [] +is_a: GO:0019322 ! pentose biosynthetic process +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0019568 +name: arabinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai] +subset: gosubset_prok +synonym: "arabinose breakdown" EXACT [] +synonym: "arabinose catabolism" EXACT [] +synonym: "arabinose degradation" EXACT [] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0019569 +name: L-arabinose catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT [] +synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT [] +xref: MetaCyc:ARABCAT-PWY +is_a: GO:0019572 ! L-arabinose catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019570 +name: L-arabinose catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT [] +synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT [] +synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT [] +xref: MetaCyc:LARA2OGCAT-PWY +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0019572 ! L-arabinose catabolic process + +[Term] +id: GO:0019571 +name: D-arabinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the dextrorotatory isomer of arabino-pentose." [GOC:go_curators] +subset: gosubset_prok +synonym: "D-arabinose breakdown" EXACT [] +synonym: "D-arabinose catabolism" EXACT [] +synonym: "D-arabinose degradation" EXACT [] +is_a: GO:0019568 ! arabinose catabolic process +is_a: GO:0046372 ! D-arabinose metabolic process + +[Term] +id: GO:0019572 +name: L-arabinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the levorotatory isomer of arabino-pentose." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-arabinose breakdown" EXACT [] +synonym: "L-arabinose catabolism" EXACT [] +synonym: "L-arabinose degradation" EXACT [] +is_a: GO:0019568 ! arabinose catabolic process +is_a: GO:0046373 ! L-arabinose metabolic process + +[Term] +id: GO:0019573 +name: D-arabinose catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT [] +synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT [] +xref: MetaCyc:DARABCAT-PWY +is_a: GO:0019571 ! D-arabinose catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019574 +name: sucrose catabolic process, using glucoside 3-dehydrogenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl] +subset: gosubset_prok +synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT [] +synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT [] +synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT [] +xref: MetaCyc:SUCROSEUTIL2-PWY +is_a: GO:0005987 ! sucrose catabolic process + +[Term] +id: GO:0019575 +name: sucrose catabolic process, using beta-fructofuranosidase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl] +subset: gosubset_prok +synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT [] +synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT [] +synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT [] +xref: MetaCyc:SUCUTIL-PWY +is_a: GO:0005987 ! sucrose catabolic process + +[Term] +id: GO:0019576 +name: aerobic fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "aerobic fructose breakdown" EXACT [] +synonym: "aerobic fructose catabolism" EXACT [] +synonym: "aerobic fructose degradation" EXACT [] +is_a: GO:0006001 ! fructose catabolic process + +[Term] +id: GO:0019577 +name: aldaric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aldaric acid metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0019578 +name: aldaric acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aldaric acid anabolism" EXACT [] +synonym: "aldaric acid biosynthesis" EXACT [] +synonym: "aldaric acid formation" EXACT [] +synonym: "aldaric acid synthesis" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019579 +name: aldaric acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aldaric acid breakdown" EXACT [] +synonym: "aldaric acid catabolism" EXACT [] +synonym: "aldaric acid degradation" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0019580 +name: galactarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactarate, the anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactarate metabolism" EXACT [] +synonym: "mucic acid metabolic process" EXACT [] +synonym: "mucic acid metabolism" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process + +[Term] +id: GO:0019582 +name: D-galactarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-galactarate breakdown" EXACT [] +synonym: "D-galactarate catabolism" EXACT [] +synonym: "D-galactarate degradation" EXACT [] +xref: MetaCyc:GALACTARDEG-PWY +is_a: GO:0046392 ! galactarate catabolic process +is_a: GO:0046393 ! D-galactarate metabolic process + +[Term] +id: GO:0019583 +name: galactonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai] +subset: gosubset_prok +synonym: "galactonate metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0019584 +name: galactonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai] +subset: gosubset_prok +synonym: "galactonate breakdown" EXACT [] +synonym: "galactonate catabolism" EXACT [] +synonym: "galactonate degradation" EXACT [] +xref: MetaCyc:GALACTCAT-PWY +is_a: GO:0019583 ! galactonate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0019585 +name: glucuronate metabolic process +namespace: biological_process +alt_id: GO:0019699 +def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glucuronate metabolism" EXACT [] +is_a: GO:0006063 ! uronic acid metabolic process + +[Term] +id: GO:0019586 +name: galacturonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galacturonate metabolism" EXACT [] +is_a: GO:0006063 ! uronic acid metabolic process + +[Term] +id: GO:0019588 +name: anaerobic glycerol catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah] +subset: gosubset_prok +synonym: "glycerol fermentation" EXACT [] +is_a: GO:0019563 ! glycerol catabolic process +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019589 +name: anaerobic glycerol catabolic process to propane-1,3-diol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY] +subset: gosubset_prok +synonym: "glycerol fermentation to 1,3-propanediol" EXACT [] +synonym: "glycerol fermentation to propane-1,3-diol" EXACT [] +xref: MetaCyc:GOLPDLCAT-PWY +is_a: GO:0019588 ! anaerobic glycerol catabolic process + +[Term] +id: GO:0019590 +name: L-arabitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] +subset: gosubset_prok +synonym: "L-arabitol and xylitol degradation" BROAD [] +synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "L-arabitol utilization" RELATED [] +xref: MetaCyc:LARABITOLUTIL-PWY +is_a: GO:0051158 ! L-arabitol catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019591 +name: arabitol utilization +namespace: biological_process +subset: gosubset_prok +is_a: GO:0051157 ! arabitol catabolic process + +[Term] +id: GO:0019592 +name: mannitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannitol breakdown" EXACT [] +synonym: "mannitol catabolism" EXACT [] +synonym: "mannitol degradation" EXACT [] +xref: MetaCyc:MANNIDEG-PWY +xref: MetaCyc:PWY-3861 +is_a: GO:0019407 ! hexitol catabolic process +is_a: GO:0019594 ! mannitol metabolic process + +[Term] +id: GO:0019593 +name: mannitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannitol anabolism" EXACT [] +synonym: "mannitol biosynthesis" EXACT [] +synonym: "mannitol formation" EXACT [] +synonym: "mannitol synthesis" EXACT [] +xref: MetaCyc:PWY-3881 +is_a: GO:0019406 ! hexitol biosynthetic process +is_a: GO:0019594 ! mannitol metabolic process + +[Term] +id: GO:0019594 +name: mannitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannitol metabolism" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process + +[Term] +id: GO:0019595 +name: non-phosphorylated glucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai] +subset: gosubset_prok +synonym: "non-phosphorylated glucose breakdown" EXACT [] +synonym: "non-phosphorylated glucose catabolism" EXACT [] +synonym: "non-phosphorylated glucose degradation" EXACT [] +xref: MetaCyc:NPGLUCAT-PWY +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0046430 ! non-phosphorylated glucose metabolic process + +[Term] +id: GO:0019596 +name: mandelate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators] +subset: gosubset_prok +synonym: "mandelate breakdown" EXACT [] +synonym: "mandelate catabolism" EXACT [] +synonym: "mandelate degradation" EXACT [] +is_a: GO:0018924 ! mandelate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0019597 +name: (R)-mandelate catabolic process to benzoate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators] +subset: gosubset_prok +synonym: "(R)-mandelate breakdown to benzoate" EXACT [] +synonym: "(R)-mandelate degradation to benzoate" EXACT [] +xref: MetaCyc:MANDELATE-DEGRADATION-PWY +is_a: GO:0018874 ! benzoate metabolic process +is_a: GO:0019596 ! mandelate catabolic process + +[Term] +id: GO:0019598 +name: (R)-mandelate catabolic process to catechol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators] +subset: gosubset_prok +synonym: "(R)-mandelate breakdown to catechol" EXACT [] +synonym: "(R)-mandelate degradation to catechol" EXACT [] +xref: MetaCyc:MANDELATE-CATECHOL-PWY +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0019596 ! mandelate catabolic process + +[Term] +id: GO:0019599 +name: (R)-4-hydroxymandelate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai] +subset: gosubset_prok +synonym: "(R)-4-hydroxymandelate breakdown" EXACT [] +synonym: "(R)-4-hydroxymandelate catabolism" EXACT [] +synonym: "(R)-4-hydroxymandelate degradation" EXACT [] +xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY +is_a: GO:0019596 ! mandelate catabolic process +is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process + +[Term] +id: GO:0019600 +name: toluene oxidation +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0019601 +name: toluene oxidation via 2-hydroxytoluene +namespace: biological_process +def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY] +subset: gosubset_prok +xref: MetaCyc:TOLUENE-DEG-2-OH-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019602 +name: toluene oxidation via 3-hydroxytoluene +namespace: biological_process +def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY] +subset: gosubset_prok +xref: MetaCyc:TOLUENE-DEG-3-OH-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019603 +name: toluene oxidation via 4-hydroxytoluene +namespace: biological_process +def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY] +subset: gosubset_prok +xref: MetaCyc:TOLUENE-DEG-4-OH-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019604 +name: toluene oxidation to catechol +namespace: biological_process +def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY] +subset: gosubset_prok +xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY +xref: UM-BBD_pathwayID:tol +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019605 +name: butyrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "butyrate metabolism" EXACT [] +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0019606 +name: 2-oxobutyrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "2-oxobutyrate breakdown" EXACT [] +synonym: "2-oxobutyrate catabolism" EXACT [] +synonym: "2-oxobutyrate degradation" EXACT [] +synonym: "alpha-ketobutyrate catabolic process" EXACT [] +synonym: "alpha-ketobutyrate catabolism" EXACT [] +xref: MetaCyc:2OXOBUTYRATECAT-PWY +is_a: GO:0046359 ! butyrate catabolic process +is_a: GO:0046361 ! 2-oxobutyrate metabolic process + +[Term] +id: GO:0019607 +name: phenylethylamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] +synonym: "phenylethylamine breakdown" EXACT [] +synonym: "phenylethylamine catabolism" EXACT [] +synonym: "phenylethylamine degradation" EXACT [] +xref: MetaCyc:2PHENDEG-PWY +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:0042402 ! biogenic amine catabolic process +is_a: GO:0042443 ! phenylethylamine metabolic process + +[Term] +id: GO:0019608 +name: nicotine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] +subset: gosubset_prok +synonym: "nicotine breakdown" EXACT [] +synonym: "nicotine catabolism" EXACT [] +synonym: "nicotine degradation" EXACT [] +xref: MetaCyc:P181-PWY +xref: UM-BBD_pathwayID:nic +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0018933 ! nicotine metabolic process + +[Term] +id: GO:0019609 +name: 3-hydroxyphenylacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "3-hydroxyphenylacetate metabolism" EXACT [] +synonym: "3HPA metabolic process" EXACT [] +synonym: "3HPA metabolism" EXACT [] +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0019610 +name: 3-hydroxyphenylacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "3-hydroxyphenylacetate breakdown" EXACT [] +synonym: "3-hydroxyphenylacetate catabolism" EXACT [] +synonym: "3-hydroxyphenylacetate degradation" EXACT [] +xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019611 +name: 4-toluenecarboxylate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] +subset: gosubset_prok +synonym: "4-toluenecarboxylate metabolism" EXACT [] +synonym: "p-toluate metabolic process" EXACT [] +synonym: "p-toluate metabolism" EXACT [] +is_a: GO:0018970 ! toluene metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019612 +name: 4-toluenecarboxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] +subset: gosubset_prok +synonym: "4-toluenecarboxylate breakdown" EXACT [] +synonym: "4-toluenecarboxylate catabolism" EXACT [] +synonym: "4-toluenecarboxylate degradation" EXACT [] +synonym: "p-toluate catabolic process" EXACT [] +synonym: "p-toluate catabolism" EXACT [] +xref: MetaCyc:4TOLCARBDEG-PWY +is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process +is_a: GO:0042203 ! toluene catabolic process + +[Term] +id: GO:0019614 +name: catechol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +subset: gosubset_prok +synonym: "catechol breakdown" EXACT [] +synonym: "catechol catabolism" EXACT [] +synonym: "catechol degradation" EXACT [] +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0019615 +name: catechol catabolic process, ortho-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/] +subset: gosubset_prok +synonym: "catechol breakdown, ortho-cleavage" EXACT [] +synonym: "catechol degradation, ortho-cleavage" EXACT [] +xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY +is_a: GO:0019614 ! catechol catabolic process +is_a: GO:0042952 ! beta-ketoadipate pathway + +[Term] +id: GO:0019616 +name: catechol catabolic process, meta-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/] +subset: gosubset_prok +synonym: "catechol breakdown, meta-cleavage" EXACT [] +synonym: "catechol degradation, meta-cleavage" EXACT [] +xref: MetaCyc:P183-PWY +is_a: GO:0019614 ! catechol catabolic process + +[Term] +id: GO:0019617 +name: protocatechuate catabolic process, meta-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY] +subset: gosubset_prok +synonym: "protocatechuate breakdown, meta-cleavage" EXACT [] +synonym: "protocatechuate degradation, meta-cleavage" EXACT [] +xref: MetaCyc:P184-PWY +is_a: GO:0019619 ! protocatechuate catabolic process + +[Term] +id: GO:0019618 +name: protocatechuate catabolic process, ortho-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY] +subset: gosubset_prok +synonym: "protocatechuate breakdown, ortho-cleavage" EXACT [] +synonym: "protocatechuate degradation, ortho-cleavage" EXACT [] +xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY +is_a: GO:0019619 ! protocatechuate catabolic process + +[Term] +id: GO:0019619 +name: protocatechuate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "protocatechuate breakdown" EXACT [] +synonym: "protocatechuate catabolism" EXACT [] +synonym: "protocatechuate degradation" EXACT [] +is_a: GO:0019614 ! catechol catabolic process +is_a: GO:0046278 ! protocatechuate metabolic process + +[Term] +id: GO:0019620 +name: aerobic benzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "aerobic benzoate metabolism" EXACT [] +is_a: GO:0018874 ! benzoate metabolic process + +[Term] +id: GO:0019621 +name: creatinine catabolic process to formate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators] +subset: gosubset_prok +synonym: "creatinine breakdown to formate" EXACT [] +synonym: "creatinine degradation to formate" EXACT [] +xref: MetaCyc:CRNFORCAT-PWY +is_a: GO:0006602 ! creatinine catabolic process +is_a: GO:0015942 ! formate metabolic process + +[Term] +id: GO:0019622 +name: 3-(3-hydroxy)phenylpropionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] +subset: gosubset_prok +synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT [] +synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT [] +synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT [] +xref: MetaCyc:HCAMHPDEG-PWY +is_a: GO:0019380 ! 3-phenylpropionate catabolic process +is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process + +[Term] +id: GO:0019623 +name: atrazine catabolic process to urea +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl] +subset: gosubset_prok +synonym: "atrazine breakdown to urea" EXACT [] +synonym: "atrazine degradation to urea" EXACT [] +xref: MetaCyc:P521-PWY +is_a: GO:0019381 ! atrazine catabolic process +is_a: GO:0019627 ! urea metabolic process + +[Term] +id: GO:0019624 +name: atrazine catabolic process to isopropylamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl] +subset: gosubset_prok +synonym: "atrazine breakdown to isopropylamine" EXACT [] +synonym: "atrazine degradation to isopropylamine" EXACT [] +xref: MetaCyc:P501-PWY +is_a: GO:0019381 ! atrazine catabolic process + +[Term] +id: GO:0019625 +name: atrazine catabolic process to cyanuric acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl] +subset: gosubset_prok +synonym: "atrazine breakdown to cyanuric acid" EXACT [] +synonym: "atrazine degradation to cyanuric acid" EXACT [] +xref: MetaCyc:P141-PWY +is_a: GO:0019381 ! atrazine catabolic process +is_a: GO:0042199 ! cyanuric acid metabolic process + +[Term] +id: GO:0019626 +name: short-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "short-chain fatty acid breakdown" EXACT [] +synonym: "short-chain fatty acid catabolism" EXACT [] +synonym: "short-chain fatty acid degradation" EXACT [] +xref: MetaCyc:ACETOACETATE-DEG-PWY +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0019627 +name: urea metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "urea metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0019628 +name: urate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "urate breakdown" EXACT [] +synonym: "urate catabolism" EXACT [] +synonym: "urate degradation" EXACT [] +synonym: "uric acid catabolic process" EXACT [] +xref: MetaCyc:P165-PWY +is_a: GO:0019627 ! urea metabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process +is_a: GO:0046415 ! urate metabolic process + +[Term] +id: GO:0019629 +name: propionate catabolic process, 2-methylcitrate cycle +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators] +subset: gosubset_prok +synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT [] +synonym: "propionate degradation, 2-methylcitrate cycle" EXACT [] +xref: MetaCyc:P361-PWY +is_a: GO:0019543 ! propionate catabolic process + +[Term] +id: GO:0019630 +name: quinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "quinate metabolism" EXACT [] +synonym: "quinic acid metabolic process" EXACT [] +synonym: "quinic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019631 +name: quinate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl] +subset: gosubset_prok +synonym: "quinate breakdown" EXACT [] +synonym: "quinate catabolism" EXACT [] +synonym: "quinate degradation" EXACT [] +synonym: "quinic acid catabolic process" EXACT [] +synonym: "quinic acid catabolism" EXACT [] +xref: MetaCyc:QUINATEDEG-PWY +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019630 ! quinate metabolic process + +[Term] +id: GO:0019632 +name: shikimate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [ChEBI:36208, GOC:sm, ISBN:0198547684] +subset: gosubset_prok +synonym: "shikimate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019633 +name: shikimate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [ChEBI:36208, GOC:go_curators] +subset: gosubset_prok +synonym: "shikimate breakdown" EXACT [] +synonym: "shikimate catabolism" EXACT [] +synonym: "shikimate degradation" EXACT [] +xref: MetaCyc:SHIKIMATEDEG-PWY +is_a: GO:0019632 ! shikimate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0019634 +name: phosphonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "phosphonate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0019635 +name: 2-aminoethylphosphonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai] +subset: gosubset_prok +synonym: "2-aminoethylphosphonate breakdown" EXACT [] +synonym: "2-aminoethylphosphonate catabolism" EXACT [] +synonym: "2-aminoethylphosphonate degradation" EXACT [] +synonym: "2-phosphonoethylamine catabolic process" EXACT [] +synonym: "2-phosphonoethylamine catabolism" EXACT [] +synonym: "ciliatine catabolic process" EXACT [] +synonym: "ciliatine catabolism" EXACT [] +xref: MetaCyc:PHOSPHONOTASE-PWY +is_a: GO:0019700 ! phosphonate catabolic process +is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process + +[Term] +id: GO:0019636 +name: phosphonoacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY] +subset: gosubset_prok +synonym: "phosphonoacetate metabolism" EXACT [] +xref: MetaCyc:P483-PWY +is_a: GO:0019634 ! phosphonate metabolic process + +[Term] +id: GO:0019637 +name: organophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. They include a number of organophosphorus compounds that were originally developed as nerve gases, but were formerly used as insecticides and anthelmintics, which worked by inhibiting serine proteases." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "organophosphate metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0019638 +name: 6-hydroxycineole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] +subset: gosubset_prok +synonym: "6-endo-hydroxycineole metabolic process" EXACT [] +synonym: "6-endo-hydroxycineole metabolism" EXACT [] +synonym: "6-hydroxycineole metabolism" EXACT [] +synonym: "hydroxycineol metabolic process" EXACT [] +synonym: "hydroxycineol metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0018904 ! organic ether metabolic process + +[Term] +id: GO:0019639 +name: 6-hydroxycineole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] +subset: gosubset_prok +synonym: "6-endo-hydroxycineole catabolic process" EXACT [] +synonym: "6-endo-hydroxycineole catabolism" EXACT [] +synonym: "6-hydroxycineole breakdown" EXACT [] +synonym: "6-hydroxycineole catabolism" EXACT [] +synonym: "6-hydroxycineole degradation" EXACT [] +synonym: "hydroxycineol catabolic process" EXACT [] +synonym: "hydroxycineol catabolism" EXACT [] +xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY +is_a: GO:0019638 ! 6-hydroxycineole metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0019640 +name: glucuronate catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT [] +synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT [] +xref: MetaCyc:GURXU5PCAT-PWY +is_a: GO:0006064 ! glucuronate catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019641 +name: Embden-Meyerhof pathway +namespace: biological_process +def: "The main pathway for anaerobic degradation of carbohydrates. Starch or glycogen is hydrolyzed to glucose 1-phosphate and then through a series of intermediates, yielding two ATP molecules per glucose and producing either pyruvate (which feeds into the tricarboxylic acid cycle) or lactate." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "Embden-Meyerhof-Parnas pathway" EXACT [] +xref: MetaCyc:GLYCOLYSIS +is_a: GO:0006096 ! glycolysis + +[Term] +id: GO:0019642 +name: anaerobic glycolysis +namespace: biological_process +subset: gosubset_prok +synonym: "modifed Embden-Meyerhof pathway" EXACT [] +xref: MetaCyc:ANAGLYCOLYSIS-PWY +xref: MetaCyc:P341-PWY +is_a: GO:0006096 ! glycolysis + +[Term] +id: GO:0019643 +name: reductive tricarboxylic acid cycle +namespace: biological_process +alt_id: GO:0019644 +def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028] +subset: gosubset_prok +synonym: "reductive carboxylate cycle" EXACT [] +synonym: "reductive carboxylic acid cycle" EXACT [] +synonym: "reductive citric acid pathway" EXACT [] +synonym: "reductive Kreb's cycle" EXACT [] +synonym: "reductive TCA cycle" EXACT [] +xref: MetaCyc:P23-PWY +xref: MetaCyc:REDCITCYC +is_a: GO:0006099 ! tricarboxylic acid cycle +is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide + +[Term] +id: GO:0019645 +name: anaerobic electron transport chain +namespace: biological_process +def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +xref: MetaCyc:ANA-ELECT-TRANS-PWY +is_a: GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0019646 +name: aerobic electron transport chain +namespace: biological_process +alt_id: GO:0006136 +alt_id: GO:0006137 +alt_id: GO:0006138 +def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "NADH-O2 electron transport" NARROW [] +synonym: "succinate-O2 electron transport" NARROW [] +synonym: "ubiquinone-8-O2 electron transport" NARROW [] +xref: MetaCyc:ELECTRON-TRANSPORT-2 +is_a: GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0019647 +name: formaldehyde assimilation via ribulose monophosphate cycle +namespace: biological_process +def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861] +subset: gosubset_prok +synonym: "formaldehyde assimilation via RuMP cycle" EXACT [] +synonym: "ribulose monophosphate cycle" BROAD [] +xref: MetaCyc:PWY-1861 +is_a: GO:0019649 ! formaldehyde assimilation + +[Term] +id: GO:0019648 +name: formaldehyde assimilation via xylulose monophosphate cycle +namespace: biological_process +def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY] +subset: gosubset_prok +synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT [] +synonym: "formaldehyde fixation cycle" EXACT [] +xref: MetaCyc:P185-PWY +is_a: GO:0019649 ! formaldehyde assimilation +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019649 +name: formaldehyde assimilation +namespace: biological_process +def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai] +subset: gosubset_prok +is_a: GO:0046292 ! formaldehyde metabolic process + +[Term] +id: GO:0019650 +name: glucose catabolic process to butanediol +namespace: biological_process +alt_id: GO:0030646 +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into 2,3-butanediol and other substances; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "butanediol fermentation" EXACT [] +synonym: "glucose fermentation to butanediol" EXACT [] +xref: MetaCyc:P125-PWY +is_a: GO:0019660 ! glycolytic fermentation +is_a: GO:0034077 ! butanediol metabolic process + +[Term] +id: GO:0019651 +name: citrate catabolic process to diacetyl +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY] +subset: gosubset_prok +synonym: "citrate fermentation to diacetyl" EXACT [] +synonym: "diacetyl fermentation" EXACT [] +xref: MetaCyc:P126-PWY +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019652 +name: lactate fermentation to propionate and acetate +namespace: biological_process +def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY] +subset: gosubset_prok +synonym: "acrylate pathway" EXACT [] +synonym: "nonrandomizing pathway" EXACT [] +synonym: "propionate fermentation" EXACT [] +xref: MetaCyc:PROPFERM-PWY +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019653 +name: anaerobic purine catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purines, yielding energy in the form of ATP." [GOC:mah] +subset: gosubset_prok +synonym: "purine fermentation" EXACT [] +xref: MetaCyc:P164-PWY +xref: MetaCyc:PWY-5044 +xref: MetaCyc:PWY-5497 +is_a: GO:0006145 ! purine base catabolic process +is_a: GO:0019666 ! nitrogenous compound catabolic process + +[Term] +id: GO:0019654 +name: acetate fermentation +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +xref: MetaCyc:P142-PWY +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019655 +name: glucose catabolic process to ethanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [ISBN:0716720094] +subset: gosubset_prok +synonym: "ethanol fermentation" EXACT [] +synonym: "glucose fermentation to ethanol" EXACT [] +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019656 +name: glucose catabolic process to D-lactate and ethanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY] +subset: gosubset_prok +synonym: "glucose fermentation to D-lactate and ethanol" EXACT [] +synonym: "heterofermentation" EXACT [] +synonym: "heterofermentative lactate fermentation" EXACT [] +synonym: "heterofermentative pathway" EXACT [] +synonym: "heterolactate fermentation" EXACT [] +synonym: "heterolactic fermentation" EXACT [] +xref: MetaCyc:P122-PWY +is_a: GO:0019659 ! glucose catabolic process to lactate +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019657 +name: pyruvate fermentation to propionate +namespace: biological_process +def: "The anaerobic conversion of pyruvate to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [MetaCyc:P108-PWY] +subset: gosubset_prok +synonym: "succinate-propionate fermentation" EXACT [] +xref: MetaCyc:P108-PWY +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019658 +name: glucose catabolic process to lactate and acetate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY] +subset: gosubset_prok +synonym: "bifidum pathway" EXACT [] +synonym: "glucose fermentation to lactate and acetate" EXACT [] +xref: MetaCyc:P124-PWY +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019659 +name: glucose catabolic process to lactate +namespace: biological_process +def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] +subset: gosubset_prok +synonym: "glucose fermentation to lactate" EXACT [] +synonym: "lactate fermentation" EXACT [] +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019660 +name: glycolytic fermentation +namespace: biological_process +def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019661 +name: glucose catabolic process to lactate via pyruvate +namespace: biological_process +def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via pyruvate, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, http://dwb.unl.edu/] +subset: gosubset_prok +synonym: "glucose fermentation to lactate via pyruvate" EXACT [] +synonym: "homofermentation" EXACT [] +synonym: "homofermentative lactate fermentation" EXACT [] +synonym: "homofermentative pathway" EXACT [] +synonym: "homolactate fermentation" EXACT [] +synonym: "homolactic fermentation" EXACT [] +is_a: GO:0019659 ! glucose catabolic process to lactate +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019662 +name: non-glycolytic fermentation +namespace: biological_process +def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019663 +name: homoacetate catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of homoacetate, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "homoacetate fermentation" EXACT [] +is_a: GO:0019654 ! acetate fermentation +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019664 +name: glucose catabolic process to mixed acids +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [MetaCyc:FERMENTATION-PWY] +subset: gosubset_prok +synonym: "glucose fermentation to mixed acids" EXACT [] +synonym: "mixed acid fermentation" EXACT [] +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019665 +name: anaerobic amino acid catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "amino acid fermentation" EXACT [] +is_a: GO:0006113 ! fermentation +is_a: GO:0009063 ! amino acid catabolic process + +[Term] +id: GO:0019666 +name: nitrogenous compound catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah] +subset: gosubset_prok +synonym: "nitrogenous compound fermentation" EXACT [] +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019667 +name: anaerobic L-alanine catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "L-alanine fermentation" EXACT [] +is_a: GO:0019665 ! anaerobic amino acid catabolic process +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019668 +name: anaerobic catabolic process of pairs of amino acids +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081] +subset: gosubset_prok +synonym: "cofermentation of pairs of amino acids" EXACT [] +synonym: "Stickland reaction" NARROW [] +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019669 +name: anaerobic glycine catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "glycine fermentation" EXACT [] +is_a: GO:0006546 ! glycine catabolic process +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019670 +name: anaerobic glutamate catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "glutamate fermentation" EXACT [] +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019671 +name: glutamate catabolic process via mesaconate and citramalate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY] +subset: gosubset_prok +synonym: "glutamate fermentation via mesaconate and citramalate" EXACT [] +xref: MetaCyc:GLUDEG-II-PWY +is_a: GO:0019670 ! anaerobic glutamate catabolic process + +[Term] +id: GO:0019672 +name: ethanol-acetate fermentation to butyrate and caproate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY] +subset: gosubset_prok +xref: MetaCyc:P127-PWY +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019673 +name: GDP-mannose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP-mannose metabolism" EXACT [] +xref: MetaCyc:MANGDPMET-PWY +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0019674 +name: NAD metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] +subset: gosubset_prok +synonym: "NAD (oxidized) metabolic process" EXACT [] +synonym: "NAD (oxidized) metabolism" EXACT [] +synonym: "NAD metabolism" EXACT [] +synonym: "NAD phosphorylation and dephosphorylation" NARROW [] +synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide metabolism" EXACT [] +synonym: "oxidized NAD metabolic process" EXACT [] +synonym: "oxidized NAD metabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT [] +is_a: GO:0006769 ! nicotinamide metabolic process + +[Term] +id: GO:0019675 +name: NAD phosphorylation and dephosphorylation +namespace: biological_process +def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] +comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist. +synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT [] +is_obsolete: true +consider: GO:0006739 +consider: GO:0019674 + +[Term] +id: GO:0019676 +name: ammonia assimilation cycle +namespace: biological_process +def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY] +subset: gosubset_prok +synonym: "glutamate metabolic process via glutamine and ammonia" EXACT [] +synonym: "glutamate metabolism via glutamine and ammonia" EXACT [] +xref: MetaCyc:AMMASSIM-PWY +xref: MetaCyc:PWY-3282 +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006541 ! glutamine metabolic process + +[Term] +id: GO:0019677 +name: NAD catabolic process +namespace: biological_process +alt_id: GO:0006737 +def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] +subset: gosubset_prok +synonym: "NAD (oxidized) catabolic process" EXACT [] +synonym: "NAD (oxidized) catabolism" EXACT [] +synonym: "NAD (reduced) catabolic process" EXACT [] +synonym: "NAD (reduced) catabolism" EXACT [] +synonym: "NAD breakdown" EXACT [] +synonym: "NAD catabolism" EXACT [] +synonym: "NAD degradation" EXACT [] +synonym: "NADH catabolic process" EXACT [] +synonym: "NADH catabolism" EXACT [] +synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide catabolism" EXACT [] +synonym: "oxidized NAD catabolic process" EXACT [] +synonym: "oxidized NAD catabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT [] +synonym: "reduced NAD catabolic process" EXACT [] +synonym: "reduced NAD catabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT [] +xref: MetaCyc:PERIPLASMA+NAD+DEGRADATION +is_a: GO:0019364 ! pyridine nucleotide catabolic process +is_a: GO:0019674 ! NAD metabolic process + +[Term] +id: GO:0019678 +name: propionate metabolic process, methylmalonyl pathway +namespace: biological_process +def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators] +subset: gosubset_prok +synonym: "propionate metabolism, methylmalonyl pathway" EXACT [] +xref: MetaCyc:PROPIONMET-PWY +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0019679 +name: propionate metabolic process, methylcitrate cycle +namespace: biological_process +def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators] +subset: gosubset_prok +synonym: "propionate metabolism, methylcitrate cycle" EXACT [] +xref: MetaCyc:PWY0-42 +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0019680 +name: L-methylmalonyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the levorotatory isomer of 2-carboxypropanoyl-CoA." [GOC:ai] +subset: gosubset_prok +synonym: "L-methylmalonyl-CoA anabolism" EXACT [] +synonym: "L-methylmalonyl-CoA biosynthesis" EXACT [] +synonym: "L-methylmalonyl-CoA formation" EXACT [] +synonym: "L-methylmalonyl-CoA synthesis" EXACT [] +xref: MetaCyc:PWY0-43 +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process + +[Term] +id: GO:0019681 +name: acetyl-CoA assimilation pathway +namespace: biological_process +def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY] +subset: gosubset_prok +synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT [] +synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT [] +xref: MetaCyc:P22-PWY +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0046356 ! acetyl-CoA catabolic process + +[Term] +id: GO:0019682 +name: glyceraldehyde-3-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT [] +synonym: "glyceraldehyde 3-phosphate metabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:0019683 +name: glyceraldehyde-3-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT [] +synonym: "glyceraldehyde 3-phosphate catabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate breakdown" EXACT [] +synonym: "glyceraldehyde-3-phosphate catabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate degradation" EXACT [] +xref: MetaCyc:P81-PWY +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process +is_a: GO:0046185 ! aldehyde catabolic process + +[Term] +id: GO:0019684 +name: photosynthesis, light reaction +namespace: biological_process +def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org] +synonym: "photolysis" EXACT [] +xref: MetaCyc:PHOTOSYN-PWY +xref: MetaCyc:PWY-101 +is_a: GO:0006091 ! generation of precursor metabolites and energy +relationship: part_of GO:0015979 ! photosynthesis + +[Term] +id: GO:0019685 +name: photosynthesis, dark reaction +namespace: biological_process +def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952] +is_a: GO:0016051 ! carbohydrate biosynthetic process +relationship: part_of GO:0015979 ! photosynthesis + +[Term] +id: GO:0019686 +name: purine nucleoside interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion + +[Term] +id: GO:0019687 +name: pyruvate biosynthetic process from acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyruvate anabolism from acetate" EXACT [] +synonym: "pyruvate formation from acetate" EXACT [] +synonym: "pyruvate synthesis from acetate" EXACT [] +xref: MetaCyc:PWY-21 +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0042866 ! pyruvate biosynthetic process + +[Term] +id: GO:0019688 +name: purine deoxyribonucleoside interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0019686 ! purine nucleoside interconversion + +[Term] +id: GO:0019689 +name: pyrimidine nucleoside interconversion +namespace: biological_process +subset: gosubset_prok +is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion + +[Term] +id: GO:0019690 +name: pyrimidine deoxyribonucleoside interconversion +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:DEOXYPYRNUCMET-PWY +is_a: GO:0019689 ! pyrimidine nucleoside interconversion + +[Term] +id: GO:0019691 +name: UDP-glucose conversion +namespace: biological_process +subset: gosubset_prok +xref: MetaCyc:P61-PW +is_a: GO:0006011 ! UDP-glucose metabolic process +is_a: GO:0009227 ! nucleotide-sugar catabolic process + +[Term] +id: GO:0019692 +name: deoxyribose phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribose phosphate metabolism" EXACT [] +xref: MetaCyc:DRIBOPMET-PWY +is_a: GO:0006014 ! D-ribose metabolic process + +[Term] +id: GO:0019693 +name: ribose phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] +subset: gosubset_prok +synonym: "ribose phosphate metabolism" EXACT [] +xref: MetaCyc:DRIBOPMET-PWY +is_a: GO:0006014 ! D-ribose metabolic process + +[Term] +id: GO:0019694 +name: alkanesulfonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:ai] +subset: gosubset_prok +synonym: "alkanesulfonate metabolism" EXACT [] +synonym: "alkanesulphonate metabolic process" EXACT [] +synonym: "alkanesulphonate metabolism" EXACT [] +xref: MetaCyc:ALKANEMONOX-PWY +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0019695 +name: choline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "choline metabolism" EXACT [] +is_a: GO:0042439 ! ethanolamine and derivative metabolic process + +[Term] +id: GO:0019696 +name: toluene oxidation via toluene-cis-1,2-dihydrodiol +namespace: biological_process +def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY] +subset: gosubset_prok +xref: MetaCyc:TOLUENE-DEG-DIOL-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019697 +name: L-xylitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] +subset: gosubset_prok +synonym: "L-arabitol and xylitol degradation" BROAD [] +synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "L-xylitol utilization" RELATED [] +xref: MetaCyc:LARABITOLUTIL-PWY +is_a: GO:0051160 ! L-xylitol catabolic process +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019698 +name: D-galacturonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the dextrorotatory isomer of galacturonate, the anion of galacturonic acid." [GOC:ai] +subset: gosubset_prok +synonym: "D-galacturonate breakdown" EXACT [] +synonym: "D-galacturonate catabolism" EXACT [] +synonym: "D-galacturonate degradation" EXACT [] +xref: MetaCyc:GALACTUROCAT-PWY +is_a: GO:0046396 ! D-galacturonate metabolic process +is_a: GO:0046397 ! galacturonate catabolic process + +[Term] +id: GO:0019700 +name: phosphonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] +subset: gosubset_prok +synonym: "phosphonate breakdown" EXACT [] +synonym: "phosphonate catabolism" EXACT [] +synonym: "phosphonate degradation" EXACT [] +is_a: GO:0019634 ! phosphonate metabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0019701 +name: peptidyl-arginine N5-methylation +namespace: biological_process +def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305] +subset: gosubset_prok +synonym: "peptidyl-arginine delta-N-methylation" EXACT [] +xref: RESID:AA0305 +is_a: GO:0035246 ! peptidyl-arginine N-methylation + +[Term] +id: GO:0019702 +name: protein-arginine N5-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues." [PMID:9873020] +synonym: "protein-arginine delta-N-methyltransferase activity" EXACT [] +synonym: "type IV PRMT activity" EXACT [] +synonym: "type IV protein arginine methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0019703 +name: coenzyme A-peptidyl-cysteine covalent linking +namespace: biological_process +def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306] +subset: gosubset_prok +xref: RESID:AA0306 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0019704 +name: peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307] +subset: gosubset_prok +synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0307 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018319 ! protein amino acid myristoylation + +[Term] +id: GO:0019705 +name: protein-cysteine S-myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an myristoyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0019107 ! myristoyltransferase activity +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0019706 +name: protein-cysteine S-palmitoleyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoleyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0016409 ! palmitoyltransferase activity +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0019707 +name: protein-cysteine S-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] +xref: EC:2.3.1.- +is_a: GO:0016417 ! S-acyltransferase activity + +[Term] +id: GO:0019708 +name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine +namespace: biological_process +def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309] +subset: gosubset_prok +synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT [] +xref: RESID:AA0309 +is_a: GO:0006501 ! C-terminal protein lipidation +is_a: GO:0008203 ! cholesterol metabolic process +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0019709 +name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide +namespace: biological_process +def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] +xref: RESID:AA0310 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0019710 +name: peptidyl-asparagine methylation +namespace: biological_process +alt_id: GO:0018018 +def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311] +subset: gosubset_prok +xref: RESID:AA0070 +xref: RESID:AA0311 +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0019711 +name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0019712 +name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid +namespace: biological_process +def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072] +subset: gosubset_prok +synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT [] +xref: RESID:AA0072 +is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine + +[Term] +id: GO:0019713 +name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine +namespace: biological_process +def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072] +subset: gosubset_prok +synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT [] +xref: RESID:AA0072 +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine +is_a: GO:0019714 ! peptidyl-glutamine esterification + +[Term] +id: GO:0019714 +name: peptidyl-glutamine esterification +namespace: biological_process +subset: gosubset_prok +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018442 ! peptidyl-glutamic acid esterification + +[Term] +id: GO:0019715 +name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid +namespace: biological_process +def: "The posttranslational hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027] +comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. +subset: gosubset_prok +xref: RESID:AA0027 +is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation + +[Term] +id: GO:0019716 +name: N-terminal peptidyl-alanine monomethylation +namespace: biological_process +def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061] +subset: gosubset_prok +xref: RESID:AA0061 +is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation + +[Term] +id: GO:0019717 +name: synaptosome +namespace: cellular_component +def: "Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +is_a: GO:0005624 ! membrane fraction + +[Term] +id: GO:0019718 +name: rough microsome +namespace: cellular_component +def: "Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +is_a: GO:0005792 ! microsome + +[Term] +id: GO:0019719 +name: smooth microsome +namespace: cellular_component +def: "Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +is_a: GO:0005792 ! microsome + +[Term] +id: GO:0019720 +name: Mo-molybdopterin cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] +subset: gosubset_prok +synonym: "Mo-molybdopterin cofactor metabolism" EXACT [] +synonym: "Moco metabolic process" BROAD [] +synonym: "Moco metabolism" BROAD [] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process + +[Term] +id: GO:0019722 +name: calcium-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ceb] +synonym: "calcium signaling" EXACT [] +synonym: "calcium signalling" EXACT [] +synonym: "calcium-mediated signalling" EXACT [] +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0019724 +name: B cell mediated immunity +namespace: biological_process +def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was improved by GO_REF:0000022. It was moved. +synonym: "B lymphocyte mediated immune effector process" EXACT [] +synonym: "B lymphocyte mediated immunity" EXACT [] +synonym: "B-cell mediated immune effector process" EXACT [] +synonym: "B-cell mediated immunity" EXACT [] +synonym: "B-lymphocyte mediated immune effector process" EXACT [] +synonym: "B-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002449 ! lymphocyte mediated immunity +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0019725 +name: cellular homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] +subset: goslim_candida +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0019726 +name: mevaldate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + NADP+ = mevaldate + NADPH + H+." [EC:1.1.1.33] +synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33] +synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33] +xref: EC:1.1.1.33 +xref: MetaCyc:MEVALDATE-REDUCTASE-(NADPH)-RXN +is_a: GO:0004495 ! mevaldate reductase activity + +[Term] +id: GO:0019727 +name: mevaldate reductase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + NAD+ = mevaldate + NADH + H+." [EC:1.1.1.32] +xref: EC:1.1.1.32 +xref: MetaCyc:MEVALDATE-REDUCTASE-RXN +is_a: GO:0004495 ! mevaldate reductase activity + +[Term] +id: GO:0019728 +name: peptidyl-allysine oxidation to 2-aminoadipic acid +namespace: biological_process +def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122] +subset: gosubset_prok +xref: RESID:AA0370 +is_a: GO:0018158 ! protein amino acid oxidation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0019729 +name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +subset: gosubset_prok +synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] +xref: RESID:AA0189 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0019730 +name: antimicrobial humoral response +namespace: biological_process +alt_id: GO:0006960 +alt_id: GO:0019735 +def: "An immune response against microbes mediated through a body fluid." [GOC:go_curators, GOC:mtg_sensu] +synonym: "antimicrobial humoral response (sensu Protostomia)" EXACT [] +synonym: "antimicrobial humoral response (sensu Vertebrata)" EXACT [] +is_a: GO:0006959 ! humoral immune response +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0019731 +name: antibacterial humoral response +namespace: biological_process +alt_id: GO:0006961 +alt_id: GO:0019733 +def: "An immune response against bacteria mediated through a body fluid." [GOC:go_curators, GOC:mtg_sensu] +synonym: "antibacterial humoral response (sensu Protostomia)" EXACT [] +synonym: "antibacterial humoral response (sensu Vertebrata)" EXACT [] +is_a: GO:0019730 ! antimicrobial humoral response +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0019732 +name: antifungal humoral response +namespace: biological_process +alt_id: GO:0006966 +alt_id: GO:0019734 +def: "An immune response against a fungus mediated through a body fluid." [GOC:go_curators, GOC:mtg_sensu] +synonym: "antifungal humoral response (sensu Protostomia)" EXACT [] +synonym: "antifungal humoral response (sensu Vertebrata)" EXACT [] +is_a: GO:0019730 ! antimicrobial humoral response +is_a: GO:0050832 ! defense response to fungus + +[Term] +id: GO:0019736 +name: peptidyl-sarcosine incorporation +namespace: biological_process +def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063] +subset: gosubset_prok +xref: RESID:AA0063 +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0019740 +name: nitrogen utilization +namespace: biological_process +subset: gosubset_prok +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0019741 +name: pentacyclic triterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentacyclic triterpenoid breakdown" EXACT [] +synonym: "pentacyclic triterpenoid catabolism" EXACT [] +synonym: "pentacyclic triterpenoid degradation" EXACT [] +is_a: GO:0016105 ! triterpenoid catabolic process +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process + +[Term] +id: GO:0019742 +name: pentacyclic triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentacyclic triterpenoid metabolism" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process + +[Term] +id: GO:0019743 +name: hopanoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] +subset: gosubset_prok +synonym: "hopanoid breakdown" EXACT [] +synonym: "hopanoid catabolism" EXACT [] +synonym: "hopanoid degradation" EXACT [] +is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process +is_a: GO:0019744 ! hopanoid metabolic process + +[Term] +id: GO:0019744 +name: hopanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] +subset: gosubset_prok +synonym: "hopanoid metabolism" EXACT [] +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process + +[Term] +id: GO:0019745 +name: pentacyclic triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pentacyclic triterpenoid anabolism" EXACT [] +synonym: "pentacyclic triterpenoid biosynthesis" EXACT [] +synonym: "pentacyclic triterpenoid formation" EXACT [] +synonym: "pentacyclic triterpenoid synthesis" EXACT [] +is_a: GO:0016104 ! triterpenoid biosynthetic process +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process + +[Term] +id: GO:0019746 +name: hopanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] +subset: gosubset_prok +synonym: "hopanoid anabolism" EXACT [] +synonym: "hopanoid biosynthesis" EXACT [] +synonym: "hopanoid formation" EXACT [] +synonym: "hopanoid synthesis" EXACT [] +is_a: GO:0019744 ! hopanoid metabolic process +is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process + +[Term] +id: GO:0019747 +name: regulation of isoprenoid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of isoprenoid metabolism" EXACT [] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0019748 +name: secondary metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "secondary metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0019749 +name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte +namespace: biological_process +def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] +is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport + +[Term] +id: GO:0019750 +name: chloroplast transport +namespace: biological_process +def: "The directed movement of a chloroplast, a chlorophyll containing plastid found in cells of algae and higher plants, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0019751 +name: polyol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [ChEBI:26191, GOC:go_curators] +subset: gosubset_prok +synonym: "polyhydric alcohol metabolic process" EXACT [] +synonym: "polyol metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process + +[Term] +id: GO:0019752 +name: carboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carboxylic acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process + +[Term] +id: GO:0019753 +name: one-carbon compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds containing a single carbon atom." [GOC:ai] +subset: gosubset_prok +synonym: "one carbon compound biosynthesis" EXACT [] +synonym: "one carbon compound biosynthetic process" EXACT [] +synonym: "one-carbon compound anabolism" EXACT [] +synonym: "one-carbon compound biosynthesis" EXACT [] +synonym: "one-carbon compound formation" EXACT [] +synonym: "one-carbon compound synthesis" EXACT [] +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0019754 +name: one-carbon compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds containing a single carbon atom." [GOC:ai] +subset: gosubset_prok +synonym: "one carbon compound catabolic process" EXACT [] +synonym: "one carbon compound catabolism" EXACT [] +synonym: "one-carbon compound breakdown" EXACT [] +synonym: "one-carbon compound catabolism" EXACT [] +synonym: "one-carbon compound degradation" EXACT [] +is_a: GO:0006730 ! one-carbon compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0019755 +name: one-carbon compound transport +namespace: biological_process +def: "The directed movement of one-carbon compounds into, out of, within or between cells." [GOC:ai] +synonym: "one carbon compound transport" EXACT [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0019756 +name: cyanogenic glycoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanogenic glycoside anabolism" EXACT [] +synonym: "cyanogenic glycoside biosynthesis" EXACT [] +synonym: "cyanogenic glycoside formation" EXACT [] +synonym: "cyanogenic glycoside synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0042341 ! cyanogenic glycoside metabolic process + +[Term] +id: GO:0019757 +name: glycosinolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] +subset: gosubset_prok +synonym: "glycosinolate metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0019758 +name: glycosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] +subset: gosubset_prok +synonym: "glycosinolate anabolism" EXACT [] +synonym: "glycosinolate biosynthesis" EXACT [] +synonym: "glycosinolate formation" EXACT [] +synonym: "glycosinolate synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0019757 ! glycosinolate metabolic process + +[Term] +id: GO:0019759 +name: glycosinolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] +subset: gosubset_prok +synonym: "glycosinolate breakdown" EXACT [] +synonym: "glycosinolate catabolism" EXACT [] +synonym: "glycosinolate degradation" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0019757 ! glycosinolate metabolic process + +[Term] +id: GO:0019760 +name: glucosinolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "glucosinolate metabolism" EXACT [] +is_a: GO:0019757 ! glycosinolate metabolic process + +[Term] +id: GO:0019761 +name: glucosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] +subset: gosubset_prok +synonym: "glucosinolate anabolism" EXACT [] +synonym: "glucosinolate biosynthesis" EXACT [] +synonym: "glucosinolate formation" EXACT [] +synonym: "glucosinolate synthesis" EXACT [] +is_a: GO:0019758 ! glycosinolate biosynthetic process +is_a: GO:0019760 ! glucosinolate metabolic process + +[Term] +id: GO:0019762 +name: glucosinolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] +subset: gosubset_prok +synonym: "glucosinolate breakdown" EXACT [] +synonym: "glucosinolate catabolism" EXACT [] +synonym: "glucosinolate degradation" EXACT [] +xref: MetaCyc:PWY-5267 +is_a: GO:0019759 ! glycosinolate catabolic process +is_a: GO:0019760 ! glucosinolate metabolic process + +[Term] +id: GO:0019763 +name: immunoglobulin receptor activity +namespace: molecular_function +alt_id: GO:0016489 +def: "Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity." [ISBN:0198547684] +synonym: "FC receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019764 +name: high affinity Fc receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] +comment: This term was made obsolete because it is an unnecessary grouping term. +is_obsolete: true +consider: GO:0019768 +consider: GO:0019771 + +[Term] +id: GO:0019765 +name: low affinity Fc receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] +comment: This term was made obsolete because it is undefined and is an unnecessary grouping term. +is_obsolete: true +consider: GO:0019769 +consider: GO:0019772 + +[Term] +id: GO:0019766 +name: IgA receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019763 ! immunoglobulin receptor activity +is_a: GO:0019862 ! IgA binding + +[Term] +id: GO:0019767 +name: IgE receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019763 ! immunoglobulin receptor activity +is_a: GO:0019863 ! IgE binding + +[Term] +id: GO:0019768 +name: high affinity IgE receptor activity +namespace: molecular_function +def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "high affinity Fc receptor activity" RELATED [] +is_a: GO:0019767 ! IgE receptor activity + +[Term] +id: GO:0019769 +name: low affinity IgE receptor activity +namespace: molecular_function +def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "low affinity Fc receptor activity" RELATED [] +is_a: GO:0019767 ! IgE receptor activity + +[Term] +id: GO:0019770 +name: IgG receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019763 ! immunoglobulin receptor activity +is_a: GO:0019864 ! IgG binding + +[Term] +id: GO:0019771 +name: high affinity IgG receptor activity +namespace: molecular_function +def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "high affinity Fc receptor activity" RELATED [] +is_a: GO:0019770 ! IgG receptor activity + +[Term] +id: GO:0019772 +name: low affinity IgG receptor activity +namespace: molecular_function +def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "low affinity Fc receptor activity" RELATED [] +is_a: GO:0019770 ! IgG receptor activity + +[Term] +id: GO:0019773 +name: proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex." [GOC:jl, GOC:mtg_sensu, GOC:proteasome, GOC:rb, PMID:10854779] +synonym: "proteasome core complex, alpha-subunit complex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0005839 ! proteasome core complex + +[Term] +id: GO:0019774 +name: proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex." [GOC:jl, GOC:mtg_sensu, GOC:proteasome, GOC:rb, PMID:10854779] +synonym: "proteasome core complex, beta-subunit complex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0005839 ! proteasome core complex + +[Term] +id: GO:0019775 +name: FAT10 ligase activity +namespace: molecular_function +def: "Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins." [GOC:mah, PMID:12826404] +synonym: "FAT10 conjugating enzyme activity" RELATED [] +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0019776 +name: Atg8 ligase activity +namespace: molecular_function +def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404] +synonym: "APG8 conjugating enzyme activity" EXACT [] +synonym: "APG8 ligase activity" EXACT [] +synonym: "Atg8 conjugating enzyme activity" EXACT [] +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0019777 +name: Atg12 ligase activity +namespace: molecular_function +def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg12 to other proteins." [GOC:mah, PMID:12826404] +synonym: "APG12 conjugating enzyme activity" EXACT [] +synonym: "APG12 ligase activity" EXACT [] +synonym: "Atg12 conjugating enzyme activity" RELATED [] +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0019778 +name: APG12 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0019779 +name: APG8 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +synonym: "APG7" EXACT [] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0019780 +name: FAT10 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0019781 +name: NEDD8 activating enzyme activity +namespace: molecular_function +alt_id: GO:0019944 +def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924] +synonym: "RUB1 activating enzyme activity" EXACT [] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0019782 +name: ISG15 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +synonym: "UBE1L" NARROW [] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0019783 +name: small conjugating protein-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] +subset: gosubset_prok +synonym: "ubiquitin-like specific protease activity" NARROW [] +synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] +is_a: GO:0008234 ! cysteine-type peptidase activity + +[Term] +id: GO:0019784 +name: NEDD8-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] +is_a: GO:0019783 ! small conjugating protein-specific protease activity + +[Term] +id: GO:0019785 +name: ISG15-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah] +is_a: GO:0019783 ! small conjugating protein-specific protease activity + +[Term] +id: GO:0019786 +name: APG8-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] +synonym: "APG8-PE hydrolase" RELATED [] +is_a: GO:0019783 ! small conjugating protein-specific protease activity + +[Term] +id: GO:0019787 +name: small conjugating protein ligase activity +namespace: molecular_function +alt_id: GO:0008639 +alt_id: GO:0008640 +def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] +subset: gosubset_prok +synonym: "E2" NARROW [] +synonym: "small protein conjugating enzyme activity" EXACT [] +synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] +synonym: "ubiquitin-like-protein ligase activity" NARROW [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0019788 +name: NEDD8 ligase activity +namespace: molecular_function +alt_id: GO:0016976 +alt_id: GO:0019945 +alt_id: GO:0042295 +def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue." [GOC:mah] +synonym: "Hub1 conjugating enzyme activity" EXACT [] +synonym: "NEDD8 conjugating enzyme activity" EXACT [] +synonym: "RUB1 conjugating enzyme activity" EXACT [] +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0019789 +name: SUMO ligase activity +namespace: molecular_function +alt_id: GO:0016930 +alt_id: GO:0019949 +def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function." [GOC:rn, PMID:11031248, PMID:11265250] +synonym: "SMT3 conjugating enzyme" EXACT [] +synonym: "SUMO conjugating enzyme activity" EXACT [] +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0019790 +name: ubiquitin-like hydrolase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0019791 +name: FAT10 hydrolase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0019792 +name: APG12 hydrolase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0019793 +name: ISG15 carrier activity +namespace: molecular_function +def: "Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/] +synonym: "interferon-stimulated gene-15 carrier activity" NARROW [] +is_a: GO:0008320 ! protein transmembrane transporter activity + +[Term] +id: GO:0019794 +name: nonprotein amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nonprotein amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0019795 +name: nonprotein amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma] +comment: Note that amino acids that do not normally occur as a constituent resident of proteins are common in plants, but relatively rare in animals, and the term should usually be applied only within the plant domain. +subset: gosubset_prok +synonym: "nonprotein amino acid anabolism" EXACT [] +synonym: "nonprotein amino acid biosynthesis" EXACT [] +synonym: "nonprotein amino acid formation" EXACT [] +synonym: "nonprotein amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0019794 ! nonprotein amino acid metabolic process + +[Term] +id: GO:0019796 +name: nonprotein amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nonprotein amino acid breakdown" EXACT [] +synonym: "nonprotein amino acid catabolism" EXACT [] +synonym: "nonprotein amino acid degradation" EXACT [] +is_a: GO:0009063 ! amino acid catabolic process +is_a: GO:0019794 ! nonprotein amino acid metabolic process + +[Term] +id: GO:0019797 +name: procollagen-proline 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7] +synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7] +synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] +synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] +synonym: "prolyl 3-hydroxylase activity" EXACT [EC:1.14.11.7] +synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7] +synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7] +xref: EC:1.14.11.7 +xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN +is_a: GO:0019798 ! procollagen-proline dioxygenase activity +is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity + +[Term] +id: GO:0019798 +name: procollagen-proline dioxygenase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah] +xref: EC:1.14.11.- +is_a: GO:0031543 ! peptidyl-proline dioxygenase activity + +[Term] +id: GO:0019799 +name: tubulin N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108] +synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108] +synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108] +synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108] +synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108] +synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] +synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108] +synonym: "TAT activity" EXACT [EC:2.3.1.108] +synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] +xref: EC:2.3.1.108 +xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN +is_a: GO:0034212 ! peptide N-acetyltransferase activity + +[Term] +id: GO:0019800 +name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan +namespace: biological_process +def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219] +subset: gosubset_prok +synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT [] +xref: RESID:AA0219 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030204 ! chondroitin sulfate metabolic process + +[Term] +id: GO:0019801 +name: cyclization of asparagine, during protein splicing +namespace: biological_process +def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302] +comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. +subset: gosubset_prok +xref: RESID:AA0302 +is_a: GO:0006528 ! asparagine metabolic process +relationship: part_of GO:0016539 ! intein-mediated protein splicing + +[Term] +id: GO:0019802 +name: cyclization of glutamine, during protein splicing +namespace: biological_process +def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0303] +comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. +subset: gosubset_prok +xref: RESID:AA0303 +is_a: GO:0006541 ! glutamine metabolic process +relationship: part_of GO:0016539 ! intein-mediated protein splicing + +[Term] +id: GO:0019803 +name: peptidyl-aspartic acid carboxylation +namespace: biological_process +def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304] +subset: gosubset_prok +xref: RESID:AA0304 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018214 ! protein amino acid carboxylation + +[Term] +id: GO:0019804 +name: quinolinate synthetase complex +namespace: cellular_component +def: "A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902] +comment: See also the molecular function term 'L-aspartate oxidase activity ; GO:0008734'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0019805 +name: quinolinate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] +subset: gosubset_prok +synonym: "quinolinate anabolism" EXACT [] +synonym: "quinolinate biosynthesis" EXACT [] +synonym: "quinolinate formation" EXACT [] +synonym: "quinolinate synthesis" EXACT [] +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046874 ! quinolinate metabolic process + +[Term] +id: GO:0019806 +name: bromide peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10] +subset: gosubset_prok +synonym: "bromoperoxidase activity" EXACT [] +xref: EC:1.11.1.- +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0019807 +name: aspartoacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15] +subset: gosubset_prok +synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15] +synonym: "acylase II" RELATED [EC:3.5.1.15] +synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15] +synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15] +synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15] +xref: EC:3.5.1.15 +xref: MetaCyc:ASPARTOACYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0019808 +name: polyamine binding +namespace: molecular_function +def: "Interacting selectively with polyamines, organic compounds containing two or more amino groups." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0019809 +name: spermidine binding +namespace: molecular_function +def: "Interacting selectively with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +is_a: GO:0019808 ! polyamine binding + +[Term] +id: GO:0019810 +name: putrescine binding +namespace: molecular_function +def: "Interacting selectively with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] +is_a: GO:0019808 ! polyamine binding + +[Term] +id: GO:0019811 +name: cocaine binding +namespace: molecular_function +def: "Interacting selectively with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0019812 +name: Type I site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748] +subset: gosubset_prok +synonym: "Type I restriction enzyme complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0019813 +name: Type III site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] +subset: gosubset_prok +synonym: "Type III restriction enzyme complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0019814 +name: immunoglobulin complex +namespace: cellular_component +def: "A multiprotein complex that functions as an antibody. Immunoglobulins (Igs) are composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. The classes of Ig are IgA, IgD, IgE, IgG and IgM; they may be embedded in the plasma membrane or circulate in the blood or lymph." [GOC:jl, ISBN:0140512713] +subset: goslim_pir +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0019815 +name: B cell receptor complex +namespace: cellular_component +alt_id: GO:0042570 +def: "A membrane-bound antigen receptor complex consisting in its basic form of an antigen-binding subunit (the membrane immunoglobulin or mIg), comprised of two identical heavy chains and two identical light chains held together by disulfide bonds, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "B cell receptor accessory molecule complex" RELATED [] +synonym: "B lymphocyte receptor complex" EXACT [] +synonym: "B-cell receptor complex" EXACT [] +synonym: "B-lymphocyte receptor complex" EXACT [] +synonym: "BCR" RELATED [] +synonym: "immunoglobulin complex, membrane bound" EXACT [] +is_a: GO:0019814 ! immunoglobulin complex +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0001772 ! immunological synapse + +[Term] +id: GO:0019816 +name: B cell receptor accessory molecule complex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a molecule and not a location or complex. +is_obsolete: true +consider: GO:0019815 + +[Term] +id: GO:0019817 +name: vesicle fusion with peroxisome +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jic] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0007031 ! peroxisome organization + +[Term] +id: GO:0019819 +name: P1 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019820 +name: P2 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019821 +name: P3 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019822 +name: P4 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019823 +name: P5 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019824 +name: P6 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019825 +name: oxygen binding +namespace: molecular_function +def: "Interacting selectively with oxygen (O2)." [GOC:jl] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "cytochrome P450" NARROW [] +synonym: "cytochrome P450 activity" RELATED [] +xref: Reactome:4477 +is_a: GO:0005488 ! binding + +[Term] +id: GO:0019826 +name: oxygen sensor activity +namespace: molecular_function +def: "Interacting selectively with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah] +is_a: GO:0019825 ! oxygen binding + +[Term] +id: GO:0019827 +name: stem cell maintenance +namespace: biological_process +def: "The process by which an organism retains a population of stem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:mah, ISBN:0878932437] +is_a: GO:0032502 ! developmental process +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0060249 ! anatomical structure homeostasis +relationship: part_of GO:0048864 ! stem cell development + +[Term] +id: GO:0019828 +name: aspartic-type endopeptidase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai] +synonym: "aspartic protease inhibitor activity" EXACT [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0019829 +name: cation-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "cation ABC transporter" NARROW [] +synonym: "plasma membrane cation-transporting ATPase" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions + +[Term] +id: GO:0019830 +name: cadmium sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046686 + +[Term] +id: GO:0019831 +name: chromate sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046687 + +[Term] +id: GO:0019832 +name: mercuric sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046689 + +[Term] +id: GO:0019833 +name: ice nucleation activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0009405 +replaced_by: GO:0042309 +replaced_by: GO:0050825 + +[Term] +id: GO:0019834 +name: phospholipase A2 inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai] +is_a: GO:0004859 ! phospholipase inhibitor activity + +[Term] +id: GO:0019835 +name: cytolysis +namespace: biological_process +def: "The rupture of cell membranes and the loss of cytoplasm." [SP_KW:KW-0204] +subset: gosubset_prok +synonym: "autolysin activity" RELATED [] +synonym: "bacteriocin activity" RELATED [] +synonym: "bacteriolytic toxin activity" RELATED [] +synonym: "holin" RELATED [] +synonym: "lysin activity" RELATED [] +synonym: "lysis" BROAD [] +synonym: "necrosis" RELATED [] +is_a: GO:0008219 ! cell death + +[Term] +id: GO:0019836 +name: hemolysis by symbiont of host red blood cells +namespace: biological_process +def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, SP_KW:KW-0354] +subset: gosubset_prok +synonym: "haemolysis in host" EXACT [] +synonym: "hemolysin activity" RELATED [] +synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001897 ! cytolysis by symbiont of host cells +is_a: GO:0052331 ! hemolysis by organism of red blood cells in other organism during symbiotic interaction + +[Term] +id: GO:0019837 +name: herbicide susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0009635 + +[Term] +id: GO:0019838 +name: growth factor binding +namespace: molecular_function +def: "Interacting selectively with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "neurotrophin TRK receptor activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019840 +name: isoprenoid binding +namespace: molecular_function +def: "Interacting selectively with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0019841 +name: retinol binding +namespace: molecular_function +def: "Interacting selectively with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [http://cancerweb.ncl.ac.uk/] +synonym: "vitamin A1 alcohol binding" EXACT [] +synonym: "vitamin A1 binding" EXACT [] +is_a: GO:0005501 ! retinoid binding +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0019842 +name: vitamin binding +namespace: molecular_function +def: "Interacting selectively with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0019843 +name: rRNA binding +namespace: molecular_function +def: "Interacting selectively with ribosomal RNA." [GOC:jl] +subset: gosubset_prok +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0019844 +name: endotoxin activity +namespace: molecular_function +def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0005622 +consider: GO:0009405 +consider: GO:0050827 + +[Term] +id: GO:0019845 +name: exotoxin activity +namespace: molecular_function +def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0005576 +consider: GO:0009405 +consider: GO:0050827 + +[Term] +id: GO:0019846 +name: enterotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0009405 +consider: GO:0050827 + +[Term] +id: GO:0019847 +name: neurotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl, http://cancerweb.ncl.ac.uk/] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0009405 +consider: GO:0050827 + +[Term] +id: GO:0019848 +name: conotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0019855 +consider: GO:0046929 + +[Term] +id: GO:0019849 +name: cytotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +comment: This term was made obsolete because it represents a class of gene products. +is_obsolete: true +consider: GO:0009405 +consider: GO:0050827 + +[Term] +id: GO:0019851 +name: D-tyrosyl-tRNA hydrolase activity +namespace: molecular_function +is_a: GO:0004045 ! aminoacyl-tRNA hydrolase activity + +[Term] +id: GO:0019852 +name: L-ascorbic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ascorbate metabolic process" EXACT [] +synonym: "ascorbate metabolism" EXACT [] +synonym: "L-ascorbic acid metabolism" EXACT [] +synonym: "vitamin C metabolic process" EXACT [] +synonym: "vitamin C metabolism" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0019853 +name: L-ascorbic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [ChEBI:38290, GOC:ma, ISBN:0198547684] +subset: gosubset_prok +synonym: "ascorbate biosynthesis" EXACT [] +synonym: "ascorbate biosynthetic process" EXACT [] +synonym: "L-ascorbic acid anabolism" EXACT [] +synonym: "L-ascorbic acid biosynthesis" EXACT [] +synonym: "L-ascorbic acid formation" EXACT [] +synonym: "L-ascorbic acid synthesis" EXACT [] +synonym: "vitamin C biosynthesis" EXACT [] +synonym: "vitamin C biosynthetic process" EXACT [] +xref: MetaCyc:PWY-882 +is_a: GO:0019852 ! L-ascorbic acid metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process + +[Term] +id: GO:0019854 +name: L-ascorbic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [ChEBI:38290, GOC:go_curators] +subset: gosubset_prok +synonym: "ascorbate catabolic process" EXACT [] +synonym: "ascorbate catabolism" EXACT [] +synonym: "L-ascorbic acid breakdown" EXACT [] +synonym: "L-ascorbic acid catabolism" EXACT [] +synonym: "L-ascorbic acid degradation" EXACT [] +synonym: "vitamin C catabolic process" EXACT [] +synonym: "vitamin C catabolism" EXACT [] +xref: MetaCyc:PWY0-301 +is_a: GO:0019852 ! L-ascorbic acid metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process + +[Term] +id: GO:0019855 +name: calcium channel inhibitor activity +namespace: molecular_function +def: "The inhibition of the passage of calcium ions through a calcium channel; the function of some venoms." [GOC:ma, SP_KW:KW-0108] +is_a: GO:0005246 ! calcium channel regulator activity +is_a: GO:0008200 ! ion channel inhibitor activity + +[Term] +id: GO:0019856 +name: pyrimidine base biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyrimidine base anabolism" EXACT [] +synonym: "pyrimidine base biosynthesis" EXACT [] +synonym: "pyrimidine base formation" EXACT [] +synonym: "pyrimidine base synthesis" EXACT [] +is_a: GO:0006206 ! pyrimidine base metabolic process +is_a: GO:0046112 ! nucleobase biosynthetic process + +[Term] +id: GO:0019857 +name: 5-methylcytosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai] +subset: gosubset_prok +synonym: "5-methylcytosine metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0019858 +name: cytosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai] +subset: gosubset_prok +synonym: "cytosine metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0019859 +name: thymine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] +subset: gosubset_prok +synonym: "thymine metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0019860 +name: uracil metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "uracil metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0019861 +name: flagellum +namespace: cellular_component +alt_id: GO:0008223 +def: "Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [SP_KW:KW-0282] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0019862 +name: IgA binding +namespace: molecular_function +def: "Interacting selectively with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019863 +name: IgE binding +namespace: molecular_function +def: "Interacting selectively with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019864 +name: IgG binding +namespace: molecular_function +def: "Interacting selectively with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019865 +name: immunoglobulin binding +namespace: molecular_function +def: "Interacting selectively with an immunoglobulin." [GOC:ma] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0019866 +name: organelle inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] +comment: See also the cellular component term 'outer membrane ; GO:0019867'. +subset: gosubset_prok +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0031967 ! organelle envelope + +[Term] +id: GO:0019867 +name: outer membrane +namespace: cellular_component +def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0019869 +name: chloride channel inhibitor activity +namespace: molecular_function +is_a: GO:0008200 ! ion channel inhibitor activity +is_a: GO:0017081 ! chloride channel regulator activity + +[Term] +id: GO:0019870 +name: potassium channel inhibitor activity +namespace: molecular_function +is_a: GO:0008200 ! ion channel inhibitor activity +is_a: GO:0015459 ! potassium channel regulator activity + +[Term] +id: GO:0019871 +name: sodium channel inhibitor activity +namespace: molecular_function +alt_id: GO:0019868 +is_a: GO:0008200 ! ion channel inhibitor activity +is_a: GO:0017080 ! sodium channel regulator activity + +[Term] +id: GO:0019872 +name: streptomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "streptomycin anabolism" EXACT [] +synonym: "streptomycin biosynthesis" EXACT [] +synonym: "streptomycin formation" EXACT [] +synonym: "streptomycin synthesis" EXACT [] +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0046343 ! streptomycin metabolic process + +[Term] +id: GO:0019873 +name: tellurium sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046690 + +[Term] +id: GO:0019874 +name: 6-aminohexanoate-cyclic-dimer hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12] +subset: gosubset_prok +synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12] +xref: EC:3.5.2.12 +xref: MetaCyc:3.5.2.12-RXN +xref: UM-BBD_enzymeID:e0674 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0019875 +name: 6-aminohexanoate-dimer hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46] +subset: gosubset_prok +synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46] +synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46] +xref: EC:3.5.1.46 +xref: MetaCyc:RXN-3962 +xref: UM-BBD_enzymeID:e0673 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0019876 +name: nylon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [SP_KW:KW-0549] +subset: gosubset_prok +synonym: "nylon breakdown" EXACT [] +synonym: "nylon catabolism" EXACT [] +synonym: "nylon degradation" EXACT [] +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042198 ! nylon metabolic process + +[Term] +id: GO:0019877 +name: diaminopimelate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684] +subset: gosubset_prok +synonym: "diaminopimelate anabolism" EXACT [] +synonym: "diaminopimelate biosynthesis" EXACT [] +synonym: "diaminopimelate formation" EXACT [] +synonym: "diaminopimelate synthesis" EXACT [] +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046451 ! diaminopimelate metabolic process +relationship: part_of GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0019878 +name: lysine biosynthetic process via aminoadipic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators] +subset: gosubset_prok +synonym: "lysine anabolism via aminoadipic acid" EXACT [] +synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT [] +synonym: "lysine biosynthesis, aminoadipic pathway" EXACT [] +synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT [] +synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT [] +synonym: "lysine formation via aminoadipic acid" EXACT [] +synonym: "lysine synthesis via aminoadipic acid" EXACT [] +is_a: GO:0009085 ! lysine biosynthetic process + +[Term] +id: GO:0019879 +name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg] +comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'. +subset: gosubset_prok +synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0019880 +name: bacteriocin susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046678 + +[Term] +id: GO:0019881 +name: streptomycin susceptibility/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046679 + +[Term] +id: GO:0019882 +name: antigen processing and presentation +namespace: biological_process +alt_id: GO:0030333 +def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] +comment: This term was improved by GO_REF:0000022. It was renamed and redefined. +synonym: "antigen presentation" EXACT [] +synonym: "antigen processing" EXACT [] +is_a: GO:0002376 ! immune system process + +[Term] +id: GO:0019883 +name: antigen processing and presentation of endogenous antigen +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] +synonym: "antigen presentation, endogenous antigen" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0019884 +name: antigen processing and presentation of exogenous antigen +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] +synonym: "antigen presentation, exogenous antigen" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0019885 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I +namespace: biological_process +alt_id: GO:0048004 +def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "antigen presentation, endogenous peptide antigen" BROAD [] +synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [] +synonym: "antigen processing, endogenous antigen via MHC class I" BROAD [] +synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I +is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen + +[Term] +id: GO:0019886 +name: antigen processing and presentation of exogenous peptide antigen via MHC class II +namespace: biological_process +alt_id: GO:0042591 +alt_id: GO:0048005 +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD [] +synonym: "antigen presentation, exogenous peptide antigen" BROAD [] +synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen +is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0019887 +name: protein kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0019888 +name: protein phosphatase regulator activity +namespace: molecular_function +def: "Modulation of the activity of a protein phosphatase enzyme." [GOC:ai] +is_a: GO:0019208 ! phosphatase regulator activity + +[Term] +id: GO:0019889 +name: pteridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pteridine metabolism" EXACT [] +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0019893 +name: DNA replication inhibitor +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +is_obsolete: true +replaced_by: GO:0008156 + +[Term] +id: GO:0019894 +name: kinesin binding +namespace: molecular_function +def: "Interacting selectively and stoichiometrically with kinesin, a cytoplasmic protein responsible for moving vesicles and organelles towards the distal end of microtubules." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0019895 +name: kinesin-associated mitochondrial adaptor activity +namespace: molecular_function +def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [http://cancerweb.ncl.ac.uk/, PMID:12495622] +is_a: GO:0019894 ! kinesin binding +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0019896 +name: axon transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] +synonym: "axon transport of mitochondria" EXACT [] +is_a: GO:0008088 ! axon cargo transport + +[Term] +id: GO:0019897 +name: extrinsic to plasma membrane +namespace: cellular_component +alt_id: GO:0000157 +def: "Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "juxtamembrane" BROAD [] +synonym: "peripheral plasma membrane protein" EXACT [] +is_a: GO:0019898 ! extrinsic to membrane +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0019898 +name: extrinsic to membrane +namespace: cellular_component +alt_id: GO:0030396 +def: "Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] +comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. +subset: gosubset_prok +synonym: "peripheral membrane protein" EXACT [] +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0019899 +name: enzyme binding +namespace: molecular_function +def: "Interacting selectively with any enzyme." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019900 +name: kinase binding +namespace: molecular_function +def: "Interacting selectively with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0019901 +name: protein kinase binding +namespace: molecular_function +def: "Interacting selectively with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] +is_a: GO:0019900 ! kinase binding + +[Term] +id: GO:0019902 +name: phosphatase binding +namespace: molecular_function +def: "Interacting selectively with any phosphatase." [GOC:jl] +subset: gosubset_prok +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0019903 +name: protein phosphatase binding +namespace: molecular_function +def: "Interacting selectively with any protein phosphatase." [GOC:jl] +subset: gosubset_prok +is_a: GO:0019902 ! phosphatase binding + +[Term] +id: GO:0019904 +name: protein domain specific binding +namespace: molecular_function +def: "Interacting selectively with a specific domain of a protein." [GOC:go_curators] +subset: gosubset_prok +synonym: "protein domain-specific binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019905 +name: syntaxin binding +namespace: molecular_function +def: "Interacting selectively with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0000149 ! SNARE binding + +[Term] +id: GO:0019907 +name: cyclin-dependent protein kinase activating kinase holoenzyme complex +namespace: cellular_component +def: "A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor." [GOC:mah, PMID:8752210] +synonym: "CAK complex" EXACT [] +synonym: "CDK-activating kinase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0019908 +name: nuclear cyclin-dependent protein kinase holoenzyme complex +namespace: cellular_component +def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] +synonym: "CDK holoenzyme" BROAD [] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0019909 +name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity +namespace: molecular_function +def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai] +synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0019910 +name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex +namespace: cellular_component +def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, UniProtKB:P35816] +comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. +synonym: "pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Eukaryota)" EXACT [] +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0019911 +name: structural constituent of myelin sheath +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0019912 +name: cyclin-dependent protein kinase activating kinase activity +namespace: molecular_function +alt_id: GO:0019913 +def: "Increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] +synonym: "CAK" EXACT [] +synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT [] +xref: EC:2.7.11.- +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0019914 +name: cyclin-dependent protein kinase activating kinase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] +synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW [] +xref: EC:2.7.1.- +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0019915 +name: sequestering of lipid +namespace: biological_process +def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:mah, PMID:11102830] +synonym: "lipid retention" EXACT [] +synonym: "lipid sequestering" EXACT [] +synonym: "lipid sequestration" EXACT [] +synonym: "lipid storage" EXACT [] +synonym: "retention of lipids" EXACT [] +synonym: "sequestering of lipids" EXACT [] +synonym: "sequestration of lipids" EXACT [] +synonym: "storage of lipids" EXACT [] +is_a: GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0019916 +name: peptidyl-D-alanine racemization, direct +namespace: biological_process +def: "The racemization of peptidyl-alanine." [RESID:AA0191] +subset: gosubset_prok +xref: RESID:AA0191 +is_a: GO:0019122 ! peptidyl-D-alanine racemization + +[Term] +id: GO:0019917 +name: peptidyl-D-alanine racemization via peptidyl-L-serine +namespace: biological_process +def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191] +subset: gosubset_prok +xref: RESID:AA0191 +is_a: GO:0019122 ! peptidyl-D-alanine racemization + +[Term] +id: GO:0019918 +name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine +namespace: biological_process +def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069] +subset: gosubset_prok +xref: RESID:AA0067 +xref: RESID:AA0069 +is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation + +[Term] +id: GO:0019919 +name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine +namespace: biological_process +def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069] +subset: gosubset_prok +synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT [] +xref: RESID:AA0068 +xref: RESID:AA0069 +is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation + +[Term] +id: GO:0019920 +name: peptidyl-1-thioglycine biosynthetic process, internal +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] +subset: gosubset_prok +synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT [] +synonym: "peptidyl-1-thioglycine formation, internal" EXACT [] +synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT [] +xref: RESID:AA0265 +is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine + +[Term] +id: GO:0019921 +name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] +subset: gosubset_prok +synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT [] +synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT [] +synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT [] +xref: RESID:AA0265 +is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine + +[Term] +id: GO:0019922 +name: protein-chromophore linkage via peptidyl-cysteine +namespace: biological_process +def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma] +subset: gosubset_prok +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0019923 +name: alpha-1-microglobulin-chromophore linkage +namespace: biological_process +def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224] +subset: gosubset_prok +xref: RESID:AA0224 +is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine + +[Term] +id: GO:0019926 +name: peptidyl-tryptophan oxidation to tryptophyl quinone +namespace: biological_process +def: "The posttranslational oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148] +comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'. +subset: gosubset_prok +is_a: GO:0018158 ! protein amino acid oxidation +is_a: GO:0018211 ! peptidyl-tryptophan modification +relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone + +[Term] +id: GO:0019927 +name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone +namespace: biological_process +def: "The posttranslational cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313] +subset: gosubset_prok +xref: RESID:AA0313 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0019928 +name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid +namespace: biological_process +def: "The posttranslational cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314] +subset: gosubset_prok +xref: RESID:AA0314 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0019929 +name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid +namespace: biological_process +def: "The posttranslational cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315] +subset: gosubset_prok +xref: RESID:AA0315 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0019930 +name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid +namespace: biological_process +def: "The posttranslational modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316] +subset: gosubset_prok +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT [] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT [] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT [] +xref: RESID:AA0316 +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0019931 +name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine +namespace: biological_process +def: "The posttranslation modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312] +subset: gosubset_prok +xref: RESID:AA0312 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0019932 +name: second-messenger-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell." [GOC:mah, ISBN:0815316194] +subset: gosubset_prok +synonym: "second messenger mediated signaling" EXACT [] +synonym: "second messenger mediated signalling" EXACT [] +synonym: "second messenger-mediated signaling" EXACT [] +synonym: "second messenger-mediated signalling" EXACT [] +synonym: "second-messenger-mediated signalling" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0019933 +name: cAMP-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:mah] +synonym: "3',5' cAMP-mediated signaling" EXACT [] +synonym: "3',5' cAMP-mediated signalling" EXACT [] +synonym: "3',5'-cAMP-mediated signaling" EXACT [] +synonym: "3',5'-cAMP-mediated signalling" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT [] +synonym: "cAMP signaling" EXACT [] +synonym: "cAMP signalling" EXACT [] +synonym: "cAMP-mediated signal transduction" EXACT [] +synonym: "cAMP-mediated signalling" EXACT [] +synonym: "cyclic AMP-mediated signaling" EXACT [] +synonym: "cyclic AMP-mediated signalling" EXACT [] +is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling + +[Term] +id: GO:0019934 +name: cGMP-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:mah] +synonym: "cGMP-mediated signalling" EXACT [] +is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling + +[Term] +id: GO:0019935 +name: cyclic-nucleotide-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response." [GOC:ceb] +subset: gosubset_prok +synonym: "cyclic-nucleotide-mediated signalling" EXACT [] +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0019936 +name: inositol phospholipid-mediated signaling +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ceb] +comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling. +synonym: "inositol phospholipid-mediated signalling" EXACT [] +is_obsolete: true +consider: GO:0048015 +consider: GO:0048016 +consider: GO:0048017 + +[Term] +id: GO:0019937 +name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic +namespace: biological_process +def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294] +subset: gosubset_prok +xref: RESID:AA0294 +is_a: GO:0018419 ! protein catenane formation +is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine + +[Term] +id: GO:0019938 +name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic +namespace: biological_process +alt_id: GO:0042266 +def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294] +subset: gosubset_prok +xref: RESID:AA0294 +is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine + +[Term] +id: GO:0019939 +name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308] +subset: gosubset_prok +synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0308 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0045235 ! protein amino acid palmitoleylation + +[Term] +id: GO:0019940 +name: SUMO-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein. +synonym: "SUMO-dependent protein breakdown" EXACT [] +synonym: "SUMO-dependent protein catabolism" EXACT [] +synonym: "SUMO-dependent protein degradation" EXACT [] +is_obsolete: true +consider: GO:0016925 +consider: GO:0016926 + +[Term] +id: GO:0019941 +name: modification-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] +subset: gosubset_prok +synonym: "modification-dependent protein breakdown" EXACT [] +synonym: "modification-dependent protein catabolism" EXACT [] +synonym: "modification-dependent protein degradation" EXACT [] +synonym: "protein degradation tagging activity" RELATED [] +synonym: "protein-ligand-dependent protein catabolic process" NARROW [] +synonym: "protein-ligand-dependent protein catabolism" NARROW [] +is_a: GO:0043632 ! modification-dependent macromolecule catabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0019942 +name: NEDD8 class-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl] +comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. +synonym: "NEDD8 class-dependent protein breakdown" EXACT [] +synonym: "NEDD8 class-dependent protein catabolism" EXACT [] +synonym: "NEDD8 class-dependent protein degradation" EXACT [] +synonym: "RUB1-dependent protein catabolic process" EXACT [] +synonym: "RUB1-dependent protein catabolism" EXACT [] +synonym: "RUB1-dependent protein degradation" EXACT [] +is_obsolete: true +consider: GO:0045116 + +[Term] +id: GO:0019948 +name: SUMO activating enzyme activity +namespace: molecular_function +alt_id: GO:0017115 +def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250] +synonym: "SMT3 activating enzyme" EXACT [] +synonym: "SUMO E1 activator enzyme" EXACT [] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0019950 +name: SMT3-dependent protein catabolic process +namespace: biological_process +alt_id: GO:0019946 +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231] +synonym: "SMT3-dependent protein breakdown" EXACT [] +synonym: "SMT3-dependent protein catabolism" EXACT [] +synonym: "SMT3-dependent protein degradation" EXACT [] +is_a: GO:0019941 ! modification-dependent protein catabolic process + +[Term] +id: GO:0019951 +name: Smt3-protein conjugation +namespace: biological_process +alt_id: GO:0019947 +def: "The covalent addition to a protein of Smt3, a ubiquitin-like protein." [GOC:jl] +synonym: "Smt3p-protein conjugation" EXACT [] +is_a: GO:0032446 ! protein modification by small protein conjugation +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0019950 ! SMT3-dependent protein catabolic process + +[Term] +id: GO:0019953 +name: sexual reproduction +namespace: biological_process +def: "The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times." [ISBN:0387520546] +is_a: GO:0000003 ! reproduction + +[Term] +id: GO:0019954 +name: asexual reproduction +namespace: biological_process +def: "The biological process by which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546] +subset: gosubset_prok +is_a: GO:0000003 ! reproduction + +[Term] +id: GO:0019955 +name: cytokine binding +namespace: molecular_function +alt_id: GO:0019965 +def: "Interacting selectively with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] +synonym: "IL binding" NARROW [] +synonym: "interleukin binding" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019956 +name: chemokine binding +namespace: molecular_function +def: "Interacting selectively with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [GOC:ai] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019957 +name: C-C chemokine binding +namespace: molecular_function +def: "Interacting selectively with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0019958 +name: C-X-C chemokine binding +namespace: molecular_function +def: "Interacting selectively with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai] +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0019959 +name: interleukin-8 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-8." [GOC:jl] +synonym: "IL-8 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding +is_a: GO:0019958 ! C-X-C chemokine binding + +[Term] +id: GO:0019960 +name: C-X3-C chemokine binding +namespace: molecular_function +def: "Interacting selectively with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0019961 +name: interferon binding +namespace: molecular_function +def: "Interacting selectively with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [http://en.wikipedia.org "Wikipedia"] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019962 +name: type I interferon binding +namespace: molecular_function +def: "Interacting selectively with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "interferon-alpha binding" NARROW [] +synonym: "interferon-alpha/beta binding" NARROW [] +synonym: "interferon-beta binding" NARROW [] +synonym: "interferon-delta binding" NARROW [] +synonym: "interferon-epsilon binding" NARROW [] +synonym: "interferon-kappa binding" NARROW [] +synonym: "interferon-omega binding" NARROW [] +synonym: "interferon-tau binding" NARROW [] +synonym: "interferon-zeta binding" NARROW [] +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0019964 +name: interferon-gamma binding +namespace: molecular_function +def: "Interacting selectively with interferon-gamma. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] +synonym: "type II interferon binding" EXACT [] +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0019966 +name: interleukin-1 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-1." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "IL-1 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019967 +name: interleukin-1, Type I, activating binding +namespace: molecular_function +synonym: "IL-1 type I, activating binding" EXACT [] +is_a: GO:0019966 ! interleukin-1 binding + +[Term] +id: GO:0019968 +name: interleukin-1, Type II, blocking binding +namespace: molecular_function +synonym: "IL-1 type II, blocking binding" EXACT [] +is_a: GO:0019966 ! interleukin-1 binding + +[Term] +id: GO:0019969 +name: interleukin-10 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-10." [GOC:jl] +synonym: "IL-10 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019970 +name: interleukin-11 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-11." [GOC:jl] +synonym: "IL-11 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019972 +name: interleukin-12 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-12." [GOC:jl] +synonym: "IL-12 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019973 +name: interleukin-13 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-13." [GOC:jl] +synonym: "IL-13 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019974 +name: interleukin-14 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-14." [GOC:jl] +synonym: "IL-14 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019975 +name: interleukin-17 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-17." [GOC:jl] +synonym: "IL-17 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019976 +name: interleukin-2 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-2." [GOC:jl] +synonym: "IL-2 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019977 +name: interleukin-21 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-21." [GOC:jl] +synonym: "IL-21 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019978 +name: interleukin-3 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-3." [GOC:jl] +synonym: "IL-3 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019979 +name: interleukin-4 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-4." [GOC:jl] +synonym: "IL-4 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019980 +name: interleukin-5 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-5." [GOC:jl] +synonym: "IL-5 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019981 +name: interleukin-6 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-6." [GOC:jl] +synonym: "IL-6 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019982 +name: interleukin-7 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-7." [GOC:jl] +synonym: "IL-7 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019983 +name: interleukin-9 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-9." [GOC:jl] +synonym: "IL-9 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019985 +name: bypass DNA synthesis +namespace: biological_process +def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized replication complex inserts a random nucleotide across from the lesion and then continues DNA synthesis beyond the lesion. This process is often mutagenic." [PMID:10535901] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0019987 +name: negative regulation of anti-apoptosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators] +synonym: "down regulation of anti-apoptosis" EXACT [] +synonym: "down-regulation of anti-apoptosis" EXACT [] +synonym: "downregulation of anti-apoptosis" EXACT [] +synonym: "inhibition of anti-apoptosis" NARROW [] +is_a: GO:0045767 ! regulation of anti-apoptosis +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0006916 ! anti-apoptosis + +[Term] +id: GO:0019988 +name: charged-tRNA amino acid modification +namespace: biological_process +alt_id: GO:0030630 +def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg] +subset: gosubset_prok +synonym: "charged tRNA amino acid modification" EXACT [] +synonym: "charged tRNA modification" EXACT [] +synonym: "charged-tRNA modification" RELATED [] +synonym: "pre-translational amino acid modification" EXACT [] +synonym: "pre-translational protein modification" EXACT [] +synonym: "pretranslation protein modification" EXACT [] +synonym: "pretranslational amino acid modification" EXACT [] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0019990 +name: pteridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pteridine breakdown" EXACT [] +synonym: "pteridine catabolism" EXACT [] +synonym: "pteridine degradation" EXACT [] +is_a: GO:0019889 ! pteridine metabolic process +is_a: GO:0042560 ! pteridine and derivative catabolic process + +[Term] +id: GO:0019991 +name: septate junction assembly +namespace: biological_process +def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, http://cancerweb.ncl.ac.uk/] +is_a: GO:0007043 ! cell-cell junction assembly +relationship: part_of GO:0043297 ! apical junction assembly + +[Term] +id: GO:0019992 +name: diacylglycerol binding +namespace: molecular_function +def: "Interacting selectively with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0020002 +name: host cell plasma membrane +namespace: cellular_component +def: "The plasma membrane surrounding a host cell." [GOC:mb] +subset: gosubset_prok +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0020003 +name: parasitophorous vacuole +namespace: cellular_component +def: "Vacuole within a host cell in which a parasite resides." [GOC:mb] +comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope. +is_a: GO:0033655 ! host cell cytoplasm part +is_a: GO:0043230 ! extracellular organelle + +[Term] +id: GO:0020004 +name: parasitophorous vacuolar space +namespace: cellular_component +def: "Space between a parasite plasma membrane and the parasitophorous vacuolar membrane." [GOC:mb] +is_a: GO:0033643 ! host cell part +is_a: GO:0044422 ! organelle part +relationship: part_of GO:0020003 ! parasitophorous vacuole + +[Term] +id: GO:0020005 +name: parasitophorous vacuolar membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a parasitophorous vacuole." [GOC:mb] +is_a: GO:0005774 ! vacuolar membrane +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0020003 ! parasitophorous vacuole + +[Term] +id: GO:0020006 +name: parasitophorous vacuolar membrane network +namespace: cellular_component +def: "Tubular network of extensions from the parasitophorous vacuolar membrane that protrude into the host cytoplasm." [PMID:3528173] +synonym: "tubulovesicular network" NARROW [] +is_a: GO:0033643 ! host cell part +is_a: GO:0044425 ! membrane part +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0020005 ! parasitophorous vacuolar membrane + +[Term] +id: GO:0020007 +name: apical complex +namespace: cellular_component +def: "Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite." [GOC:mb] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0020008 +name: rhoptry +namespace: cellular_component +def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398] +synonym: "paired organelles" RELATED [] +synonym: "toxoneme" RELATED [] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020009 +name: microneme +namespace: cellular_component +def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218] +synonym: "sarconeme" RELATED [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020010 +name: conoid +namespace: cellular_component +def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of mictotubules." [GOC:expert_dr, PMID:11901169, PMID:16518471] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020011 +name: apicoplast +namespace: cellular_component +def: "The plastid organelle found in apicomplexans." [ISBN:0521664470] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0020012 +name: evasion or tolerance of host immune response +namespace: biological_process +def: "Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] +subset: gosubset_prok +synonym: "immune evasion" BROAD [] +is_a: GO:0030682 ! evasion or tolerance of host defense response +is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0020013 +name: rosetting +namespace: biological_process +def: "The binding of parasite infected erythrocytes to uninfected erythrocytes." [GOC:mb] +is_a: GO:0007157 ! heterophilic cell adhesion + +[Term] +id: GO:0020014 +name: schizogony +namespace: biological_process +def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0020015 +name: glycosome +namespace: cellular_component +def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0020016 +name: flagellar pocket +namespace: cellular_component +def: "Invagination of the plasma membrane from which a flagellum protrudes." [GOC:mb] +is_a: GO:0044442 ! microtubule-based flagellum part + +[Term] +id: GO:0020017 +name: flagellar membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the flagellum." [GOC:mah, GOC:mb] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0044442 ! microtubule-based flagellum part + +[Term] +id: GO:0020018 +name: flagellar pocket membrane +namespace: cellular_component +def: "That part of the plasma membrane found in the flagellar pocket." [GOC:mb] +is_a: GO:0020017 ! flagellar membrane +relationship: part_of GO:0020016 ! flagellar pocket + +[Term] +id: GO:0020020 +name: food vacuole +namespace: cellular_component +alt_id: GO:0005772 +def: "Vacuole within a parasite used for digestion of the host cell cytoplasm." [GOC:mb] +synonym: "digestive vacuole" EXACT [] +synonym: "food vacuole (sensu Apicomplexa)" EXACT [] +is_a: GO:0032010 ! phagolysosome + +[Term] +id: GO:0020021 +name: immortalization of host cell +namespace: biological_process +def: "The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] +synonym: "host cell immortalization" EXACT [] +synonym: "host cell transformation" EXACT [] +synonym: "transformation of host cell" EXACT [] +is_a: GO:0051701 ! interaction with host + +[Term] +id: GO:0020022 +name: acidocalcisome +namespace: cellular_component +def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb] +subset: goslim_pir +synonym: "metachromatic granule" EXACT [PMID:15738951] +synonym: "polyphosphate vacuole" RELATED [PMID:15738951] +synonym: "volutin granule" EXACT [PMID:15738951] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0020023 +name: kinetoplast +namespace: cellular_component +def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb] +is_a: GO:0044429 ! mitochondrial part + +[Term] +id: GO:0020025 +name: subpellicular microtubule +namespace: cellular_component +def: "Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid." [GOC:mb] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020026 +name: merozoite dense granule +namespace: cellular_component +def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu] +synonym: "dense body" EXACT [] +synonym: "dense granule (sensu Apicomplexa)" EXACT [] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0020027 +name: hemoglobin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl] +synonym: "haemoglobin metabolic process" EXACT [] +synonym: "haemoglobin metabolism" EXACT [] +synonym: "hemoglobin metabolism" EXACT [] +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0020028 +name: hemoglobin import +namespace: biological_process +def: "The directed movement into a tissue, cell or organelle of externally available hemoglobin." [GOC:mb] +synonym: "haemoglobin uptake" EXACT [] +synonym: "hemoglobin uptake" EXACT [] +is_a: GO:0017038 ! protein import + +[Term] +id: GO:0020030 +name: infected host cell surface knob +namespace: cellular_component +def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte." [GOC:mb] +synonym: "knob (sensu Plasmodium)" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0020031 +name: polar ring of apical complex +namespace: cellular_component +def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471] +synonym: "anterior polar ring of apical complex" EXACT [] +synonym: "upper polar ring of apical complex" EXACT [] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020032 +name: basal ring of apical complex +namespace: cellular_component +def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471] +synonym: "lower polar ring of apical complex" EXACT [] +synonym: "posterior polar ring of apical complex" EXACT [] +synonym: "preconoidal ring of apical complex" EXACT [] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020033 +name: antigenic variation +namespace: biological_process +alt_id: GO:0020034 +def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb] +subset: gosubset_prok +synonym: "surface antigen variation" NARROW [] +is_a: GO:0051809 ! passive evasion of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0020035 +name: cytoadherence to microvasculature, mediated by parasite protein +namespace: biological_process +def: "The adherence of parasite-infected erythrocytes to microvascular endothelium via parasite proteins embedded in the membrane of the erythrocyte." [GOC:mb] +synonym: "cytoadherence to microvasculature, mediated by symbiont protein" BROAD [] +synonym: "parasite-protein-mediated cytoadherence to microvasculature" EXACT [] +synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD [] +is_a: GO:0044406 ! adhesion to host + +[Term] +id: GO:0020036 +name: Maurer's cleft +namespace: cellular_component +def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0020037 +name: heme binding +namespace: molecular_function +def: "Interacting selectively with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai] +subset: gosubset_prok +synonym: "haem binding" EXACT [] +is_a: GO:0046906 ! tetrapyrrole binding + +[Term] +id: GO:0020038 +name: subpellicular network +namespace: cellular_component +def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0020039 ! pellicle + +[Term] +id: GO:0020039 +name: pellicle +namespace: cellular_component +def: "The cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mb] +is_a: GO:0044430 ! cytoskeletal part + +[Term] +id: GO:0021501 +name: prechordal plate formation +namespace: biological_process +def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0021502 +name: neural fold elevation formation +namespace: biological_process +def: "The process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0001842 ! neural fold formation + +[Term] +id: GO:0021503 +name: neural fold bending +namespace: biological_process +def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001842 ! neural fold formation + +[Term] +id: GO:0021504 +name: neural fold hinge point formation +namespace: biological_process +def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] +comment: This term was added by GO_REF:0000021. +synonym: "neural fold furrowing" NARROW [GOC:cls] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021503 ! neural fold bending + +[Term] +id: GO:0021505 +name: neural fold folding +namespace: biological_process +def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021503 ! neural fold bending + +[Term] +id: GO:0021506 +name: anterior neuropore closure +namespace: biological_process +def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021995 ! neuropore closure + +[Term] +id: GO:0021507 +name: posterior neuropore closure +namespace: biological_process +def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0021995 ! neuropore closure + +[Term] +id: GO:0021508 +name: floor plate formation +namespace: biological_process +def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007418 ! ventral midline development +relationship: part_of GO:0021990 ! neural plate formation + +[Term] +id: GO:0021509 +name: roof plate formation +namespace: biological_process +def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15936325] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0001841 ! neural tube formation + +[Term] +id: GO:0021510 +name: spinal cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021511 +name: spinal cord patterning +namespace: biological_process +def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021512 +name: spinal cord anterior/posterior patterning +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "spinal cord anterior-posterior patterning" EXACT [] +synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0021511 ! spinal cord patterning + +[Term] +id: GO:0021513 +name: spinal cord dorsal/ventral patterning +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "spinal cord dorsal-ventral patterning" EXACT [] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0021511 ! spinal cord patterning + +[Term] +id: GO:0021514 +name: ventral spinal cord interneuron differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021517 ! ventral spinal cord development + +[Term] +id: GO:0021515 +name: cell differentiation in spinal cord +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021516 +name: dorsal spinal cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11179871] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021517 +name: ventral spinal cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021518 +name: spinal cord commissural neuron specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021528 ! commissural neuron differentiation in the spinal cord + +[Term] +id: GO:0021519 +name: spinal cord association neuron specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021527 ! spinal cord association neuron differentiation + +[Term] +id: GO:0021520 +name: spinal cord motor neuron cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation + +[Term] +id: GO:0021521 +name: ventral spinal cord interneuron specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation + +[Term] +id: GO:0021522 +name: spinal cord motor neuron differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021517 ! ventral spinal cord development + +[Term] +id: GO:0021523 +name: somatic motor neuron differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021522 ! spinal cord motor neuron differentiation + +[Term] +id: GO:0021524 +name: visceral motor neuron differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021522 ! spinal cord motor neuron differentiation + +[Term] +id: GO:0021525 +name: lateral motor column neuron differentiation +namespace: biological_process +def: "The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021523 ! somatic motor neuron differentiation + +[Term] +id: GO:0021526 +name: medial motor column neuron differentiation +namespace: biological_process +def: "The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021523 ! somatic motor neuron differentiation + +[Term] +id: GO:0021527 +name: spinal cord association neuron differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021516 ! dorsal spinal cord development + +[Term] +id: GO:0021528 +name: commissural neuron differentiation in the spinal cord +namespace: biological_process +def: "The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0021529 +name: spinal cord oligodendrocyte cell differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0021530 +name: spinal cord oligodendrocyte cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021778 ! oligodendrocyte cell fate specification +relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation + +[Term] +id: GO:0021531 +name: radial glial cell differentiation in the spinal cord +namespace: biological_process +def: "The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16185248] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010001 ! glial cell differentiation +is_a: GO:0060019 ! radial glial cell differentiation + +[Term] +id: GO:0021532 +name: neural tube patterning +namespace: biological_process +def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0021533 +name: cell differentiation in hindbrain +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021534 +name: cell proliferation in hindbrain +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021535 +name: cell migration in hindbrain +namespace: biological_process +def: "The orderly movement of cells that will reside in the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021536 +name: diencephalon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021537 +name: telencephalon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021538 +name: epithalamus development +namespace: biological_process +def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021539 +name: subthalamus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "ventral thalamus development" RELATED [GOC:cls] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021540 +name: corpus callosum morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the corpus callosum are generated and organized. Morphogenesis pertains to the creation of form. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis +relationship: part_of GO:0022038 ! corpus callosum development + +[Term] +id: GO:0021541 +name: ammon gyrus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "Ammon's horn development" RELATED [GOC:cls] +synonym: "cornu ammonis development" RELATED [GOC:cls] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021766 ! hippocampus development + +[Term] +id: GO:0021542 +name: dentate gyrus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021766 ! hippocampus development + +[Term] +id: GO:0021543 +name: pallium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021544 +name: subpallium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021545 +name: cranial nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021675 ! nerve development + +[Term] +id: GO:0021546 +name: rhombomere development +namespace: biological_process +def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021547 +name: midbrain-hindbrain boundary initiation +namespace: biological_process +def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jic, GOC:mtg_15jun06, PMID:15541513] +comment: This term was added by GO_REF:0000021. +synonym: "isthmus biosynthesis" RELATED [GOC:cls] +synonym: "isthmus formation" RELATED [GOC:cls] +synonym: "MHB biosynthesis" EXACT [GOC:cls] +synonym: "MHB formation" EXACT [GOC:cls] +synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] +synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021999 ! neural plate anterioposterior pattern formation +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development + +[Term] +id: GO:0021548 +name: pons development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0022037 ! metencephalon development + +[Term] +id: GO:0021549 +name: cerebellum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0022037 ! metencephalon development + +[Term] +id: GO:0021550 +name: medulla oblongata development +namespace: biological_process +def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "medulla development" RELATED [GOC:cls] +synonym: "myelencephalon development" RELATED [GOC:cls] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021551 +name: central nervous system morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the central nervous system is generated and organized. Morphogenesis pertains to the creation of form. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021552 +name: midbrain-hindbrain boundary structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513] +comment: This term was added by GO_REF:0000021. +synonym: "isthmus structural organization" RELATED [GOC:cls] +synonym: "MHB structural organization" EXACT [GOC:cls] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis + +[Term] +id: GO:0021553 +name: olfactory nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN 1 development" RELATED [GOC:cls] +synonym: "cranial nerve 1 development" EXACT [GOC:cls] +synonym: "cranial nerve I development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021554 +name: optic nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN II development" RELATED [GOC:cls] +synonym: "cranial nerve 2 development" EXACT [GOC:cls] +synonym: "cranial nerve II development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021555 +name: midbrain-hindbrain boundary morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. Morphogenesis pertains to the creation of form. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513] +comment: This term was added by GO_REF:0000021. +synonym: "isthmus morphogenesis" EXACT [GOC:cls] +synonym: "MHB morphogenesis" EXACT [GOC:cls] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development + +[Term] +id: GO:0021556 +name: central nervous system formation +namespace: biological_process +def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021551 ! central nervous system morphogenesis + +[Term] +id: GO:0021557 +name: oculomotor nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN III development" RELATED [GOC:cls] +synonym: "cranial nerve 3 development" EXACT [GOC:cls] +synonym: "cranial nerve III development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development + +[Term] +id: GO:0021558 +name: trochlear nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IV development" RELATED [GOC:cls] +synonym: "cranial nerve 4 development" EXACT [GOC:cls] +synonym: "cranial nerve IV development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021559 +name: trigeminal nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN V development" RELATED [GOC:cls] +synonym: "cranial nerve 5 development" EXACT [GOC:cls] +synonym: "cranial nerve V development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021560 +name: abducens nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VI development" RELATED [GOC:cls] +synonym: "cranial nerve 6 development" EXACT [GOC:cls] +synonym: "cranial nerve VI development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021561 +name: facial nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII development" RELATED [GOC:cls] +synonym: "cranial nerve 7 development" EXACT [GOC:cls] +synonym: "cranial nerve VII development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development + +[Term] +id: GO:0021562 +name: vestibulocochlear nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "acoustic nerve development" EXACT [PMID:11533729] +synonym: "CN VIII development" EXACT [GOC:cls] +synonym: "cranial nerve 8 development" EXACT [GOC:cls] +synonym: "cranial nerve VIII development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021563 +name: glossopharyngeal nerve development +namespace: biological_process +def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IX development" RELATED [GOC:cls] +synonym: "cranial nerve 9 development" EXACT [GOC:cls] +synonym: "cranial nerve IX development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021564 +name: vagus nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN X development" RELATED [GOC:cls] +synonym: "cranial nerve 10 development" RELATED [GOC:cls] +synonym: "cranial nerve X development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development + +[Term] +id: GO:0021565 +name: accessory nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XI development" RELATED [GOC:cls] +synonym: "cranial nerve 11 development" RELATED [GOC:cls] +synonym: "cranial nerve XI development" EXACT [GOC:cls] +synonym: "spinal accessory nerve development" EXACT [PMID:11533729] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021566 +name: hypoglossal nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XII development" RELATED [GOC:cls] +synonym: "cranial nerve 12 development" RELATED [GOC:cls] +synonym: "cranial nerve XII development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021567 +name: rhombomere 1 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021568 +name: rhombomere 2 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021569 +name: rhombomere 3 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021570 +name: rhombomere 4 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021571 +name: rhombomere 5 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021572 +name: rhombomere 6 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021573 +name: rhombomere 7 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021574 +name: rhombomere 8 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021575 +name: hindbrain morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the hindbrain is generated and organized. Morphogenesis pertains to the creation of form. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "rhombencephalon morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021576 +name: hindbrain formation +namespace: biological_process +def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021577 +name: hindbrain structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021578 +name: hindbrain maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021626 ! central nervous system maturation +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021579 +name: medulla oblongata morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the medulla oblongata is generated and organized. Morphogenesis pertains to the creation of form. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "medulla morphogenesis" RELATED [] +synonym: "myelencephalon morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021550 ! medulla oblongata development +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021580 +name: medulla oblongata formation +namespace: biological_process +def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "medulla biosynthesis" RELATED [] +synonym: "medulla formation" RELATED [] +synonym: "myelencephalon biosynthesis" RELATED [] +synonym: "myelencephalon formation" RELATED [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021576 ! hindbrain formation +relationship: part_of GO:0021579 ! medulla oblongata morphogenesis + +[Term] +id: GO:0021581 +name: medulla oblongata structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "medulla structural maturation" RELATED [] +synonym: "myelencephalon structural maturation" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021577 ! hindbrain structural organization +relationship: part_of GO:0021579 ! medulla oblongata morphogenesis + +[Term] +id: GO:0021582 +name: medulla oblongata maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "medulla maturation" RELATED [] +synonym: "myelencephalon maturation" RELATED [] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021550 ! medulla oblongata development +relationship: part_of GO:0021578 ! hindbrain maturation + +[Term] +id: GO:0021583 +name: pons morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the pons is generated and organized. Morphogenesis pertains to the creation of form. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021548 ! pons development +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021584 +name: pons formation +namespace: biological_process +def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021576 ! hindbrain formation +relationship: part_of GO:0021583 ! pons morphogenesis + +[Term] +id: GO:0021585 +name: pons structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021577 ! hindbrain structural organization +relationship: part_of GO:0021583 ! pons morphogenesis + +[Term] +id: GO:0021586 +name: pons maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021548 ! pons development +relationship: part_of GO:0021578 ! hindbrain maturation + +[Term] +id: GO:0021587 +name: cerebellum morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the cerebellum is generated and organized. Morphogenesis pertains to the creation of form. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021549 ! cerebellum development +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021588 +name: cerebellum formation +namespace: biological_process +def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021576 ! hindbrain formation +relationship: part_of GO:0021587 ! cerebellum morphogenesis + +[Term] +id: GO:0021589 +name: cerebellum structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021577 ! hindbrain structural organization +relationship: part_of GO:0021587 ! cerebellum morphogenesis + +[Term] +id: GO:0021590 +name: cerebellum maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021549 ! cerebellum development +relationship: part_of GO:0021578 ! hindbrain maturation + +[Term] +id: GO:0021591 +name: ventricular system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048731 ! system development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0021592 +name: fourth ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0683400078] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021591 ! ventricular system development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021593 +name: rhombomere morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the rhombomere is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0021594 +name: rhombomere formation +namespace: biological_process +def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021593 ! rhombomere morphogenesis + +[Term] +id: GO:0021595 +name: rhombomere structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021593 ! rhombomere morphogenesis + +[Term] +id: GO:0021597 +name: central nervous system structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021551 ! central nervous system morphogenesis + +[Term] +id: GO:0021598 +name: abducens nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the abducens nerve is generated and organized. Morphogenesis pertains to the creation of form. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VI development" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021560 ! abducens nerve development + +[Term] +id: GO:0021599 +name: abducens nerve formation +namespace: biological_process +def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VI biosynthesis" RELATED [] +synonym: "CN VI formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021598 ! abducens nerve morphogenesis + +[Term] +id: GO:0021600 +name: abducens nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VI structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021598 ! abducens nerve morphogenesis + +[Term] +id: GO:0021601 +name: abducens nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VI maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021560 ! abducens nerve development + +[Term] +id: GO:0021602 +name: cranial nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021603 +name: cranial nerve formation +namespace: biological_process +def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021602 ! cranial nerve morphogenesis + +[Term] +id: GO:0021604 +name: cranial nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021602 ! cranial nerve morphogenesis + +[Term] +id: GO:0021605 +name: cranial nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021682 ! nerve maturation +relationship: part_of GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021606 +name: accessory nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XI maturation" RELATED [] +synonym: "spinal accessory nerve maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021565 ! accessory nerve development + +[Term] +id: GO:0021607 +name: accessory nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the accessory nerve is generated and organized. Morphogenesis pertains to the creation of form. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XI morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021565 ! accessory nerve development + +[Term] +id: GO:0021608 +name: accessory nerve formation +namespace: biological_process +def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XI biosynthesis" RELATED [] +synonym: "CN XI formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021607 ! accessory nerve morphogenesis + +[Term] +id: GO:0021609 +name: accessory nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XI structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021607 ! accessory nerve morphogenesis + +[Term] +id: GO:0021610 +name: facial nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the facial nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021561 ! facial nerve development + +[Term] +id: GO:0021611 +name: facial nerve formation +namespace: biological_process +def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII biosynthesis" RELATED [] +synonym: "CN VII formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021610 ! facial nerve morphogenesis + +[Term] +id: GO:0021612 +name: facial nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021610 ! facial nerve morphogenesis + +[Term] +id: GO:0021613 +name: facial nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021561 ! facial nerve development + +[Term] +id: GO:0021614 +name: glossopharyngeal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IX maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021563 ! glossopharyngeal nerve development + +[Term] +id: GO:0021615 +name: glossopharyngeal nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the glossopharyngeal nerve is generated and organized. Morphogenesis pertains to the creation of form. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IX morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021563 ! glossopharyngeal nerve development + +[Term] +id: GO:0021616 +name: glossopharyngeal nerve formation +namespace: biological_process +def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IX biosynthesis" RELATED [] +synonym: "CN IX formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis + +[Term] +id: GO:0021617 +name: glossopharyngeal nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IX structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis + +[Term] +id: GO:0021618 +name: hypoglossal nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the hypoglossal nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XII morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021566 ! hypoglossal nerve development + +[Term] +id: GO:0021619 +name: hypoglossal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021566 ! hypoglossal nerve development + +[Term] +id: GO:0021620 +name: hypoglossal nerve formation +namespace: biological_process +def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XII biosynthesis" RELATED [] +synonym: "CN XII formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis + +[Term] +id: GO:0021621 +name: hypoglossal nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN XII structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis + +[Term] +id: GO:0021622 +name: oculomotor nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the oculomotor nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN III morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021557 ! oculomotor nerve development + +[Term] +id: GO:0021623 +name: oculomotor nerve formation +namespace: biological_process +def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN III biosynthesis" RELATED [] +synonym: "CN III formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis + +[Term] +id: GO:0021624 +name: oculomotor nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN III structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis + +[Term] +id: GO:0021625 +name: oculomotor nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN III maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021557 ! oculomotor nerve development + +[Term] +id: GO:0021626 +name: central nervous system maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021627 +name: olfactory nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the olfactory nerve is generated and organized. Morphogenesis pertains to the creation of form. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN I morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021553 ! olfactory nerve development + +[Term] +id: GO:0021628 +name: olfactory nerve formation +namespace: biological_process +def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN I biosynthesis" RELATED [] +synonym: "CN I formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021627 ! olfactory nerve morphogenesis + +[Term] +id: GO:0021629 +name: olfactory nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN I structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021627 ! olfactory nerve morphogenesis + +[Term] +id: GO:0021630 +name: olfactory nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "CN I maturation" EXACT [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021553 ! olfactory nerve development + +[Term] +id: GO:0021631 +name: optic nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the optic nerve is generated and organized. Morphogenesis pertains to the creation of form. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN II morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021554 ! optic nerve development + +[Term] +id: GO:0021632 +name: optic nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN II maturation" EXACT [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021554 ! optic nerve development + +[Term] +id: GO:0021633 +name: optic nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN II structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021631 ! optic nerve morphogenesis + +[Term] +id: GO:0021634 +name: optic nerve formation +namespace: biological_process +def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN II biosynthesis" RELATED [] +synonym: "CN II formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021631 ! optic nerve morphogenesis + +[Term] +id: GO:0021635 +name: trigeminal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN V maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021559 ! trigeminal nerve development + +[Term] +id: GO:0021636 +name: trigeminal nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the trigeminal nerve is generated and organized. Morphogenesis pertains to the creation of form. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN V morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021559 ! trigeminal nerve development + +[Term] +id: GO:0021637 +name: trigeminal nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN V structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis + +[Term] +id: GO:0021638 +name: trigeminal nerve formation +namespace: biological_process +def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN V biosynthesis" RELATED [] +synonym: "CN V formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis + +[Term] +id: GO:0021639 +name: trochlear nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the trochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CH IV morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021558 ! trochlear nerve development + +[Term] +id: GO:0021640 +name: trochlear nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IV maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021558 ! trochlear nerve development + +[Term] +id: GO:0021641 +name: trochlear nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IV structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021639 ! trochlear nerve morphogenesis + +[Term] +id: GO:0021642 +name: trochlear nerve formation +namespace: biological_process +def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN IV biosynthesis" RELATED [] +synonym: "CN IV formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021639 ! trochlear nerve morphogenesis + +[Term] +id: GO:0021643 +name: vagus nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN X maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021564 ! vagus nerve development + +[Term] +id: GO:0021644 +name: vagus nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN X morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021564 ! vagus nerve development + +[Term] +id: GO:0021645 +name: vagus nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN X structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021644 ! vagus nerve morphogenesis + +[Term] +id: GO:0021646 +name: vagus nerve formation +namespace: biological_process +def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN X biosynthesis" RELATED [] +synonym: "CN X formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021644 ! vagus nerve morphogenesis + +[Term] +id: GO:0021647 +name: vestibulocochlear nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "auditory nerve maturation" RELATED [] +synonym: "CN VIII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021562 ! vestibulocochlear nerve development + +[Term] +id: GO:0021648 +name: vestibulocochlear nerve morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the vestibulocochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VIII morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021562 ! vestibulocochlear nerve development + +[Term] +id: GO:0021649 +name: vestibulocochlear nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis + +[Term] +id: GO:0021650 +name: vestibulocochlear nerve formation +namespace: biological_process +def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "CN VII formation " RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis + +[Term] +id: GO:0021651 +name: rhombomere 1 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 1 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021567 ! rhombomere 1 development + +[Term] +id: GO:0021652 +name: rhombomere 1 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis + +[Term] +id: GO:0021653 +name: rhombomere 1 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis + +[Term] +id: GO:0021654 +name: rhombomere boundary formation +namespace: biological_process +def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0021594 ! rhombomere formation + +[Term] +id: GO:0021655 +name: rhombomere 2 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 2 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021568 ! rhombomere 2 development + +[Term] +id: GO:0021656 +name: rhombomere 2 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis + +[Term] +id: GO:0021657 +name: rhombomere 2 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis + +[Term] +id: GO:0021658 +name: rhombomere 3 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 3 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021569 ! rhombomere 3 development + +[Term] +id: GO:0021659 +name: rhombomere 3 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis + +[Term] +id: GO:0021660 +name: rhombomere 3 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis + +[Term] +id: GO:0021661 +name: rhombomere 4 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 4 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021570 ! rhombomere 4 development + +[Term] +id: GO:0021662 +name: rhombomere 4 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis + +[Term] +id: GO:0021663 +name: rhombomere 4 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis + +[Term] +id: GO:0021664 +name: rhombomere 5 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of rhombomere 5 are generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021571 ! rhombomere 5 development + +[Term] +id: GO:0021665 +name: rhombomere 5 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis + +[Term] +id: GO:0021666 +name: rhombomere 5 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis + +[Term] +id: GO:0021667 +name: rhombomere 6 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 6 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021572 ! rhombomere 6 development + +[Term] +id: GO:0021668 +name: rhombomere 6 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis + +[Term] +id: GO:0021669 +name: rhombomere 6 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis + +[Term] +id: GO:0021670 +name: lateral ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0683400078] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development +relationship: part_of GO:0021591 ! ventricular system development + +[Term] +id: GO:0021671 +name: rhombomere 7 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 7 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021573 ! rhombomere 7 development + +[Term] +id: GO:0021672 +name: rhombomere 7 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis + +[Term] +id: GO:0021673 +name: rhombomere 7 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis + +[Term] +id: GO:0021674 +name: rhombomere 8 morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of rhombomere 8 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021574 ! rhombomere 8 development + +[Term] +id: GO:0021675 +name: nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0021676 +name: rhombomere 8 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis + +[Term] +id: GO:0021677 +name: rhombomere 8 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis + +[Term] +id: GO:0021678 +name: third ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0683400078] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021591 ! ventricular system development + +[Term] +id: GO:0021679 +name: cerebellar molecular layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021680 +name: cerebellar Purkinje cell layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021681 +name: cerebellar granular layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021682 +name: nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021675 ! nerve development + +[Term] +id: GO:0021683 +name: cerebellar granular layer morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the cerebellar granular layer is generated and organized. Morphogenesis pertains to the creation of form. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021681 ! cerebellar granular layer development +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021684 +name: cerebellar granular layer formation +namespace: biological_process +def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021685 +name: cerebellar granular layer structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis +relationship: part_of GO:0021698 ! cerebellar cortex structural organization + +[Term] +id: GO:0021686 +name: cerebellar granular layer maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021681 ! cerebellar granular layer development +relationship: part_of GO:0021699 ! cerebellar cortex maturation + +[Term] +id: GO:0021687 +name: cerebellar molecular layer morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the cerebellar molecular layer is generated and organized. Morphogenesis pertains to the creation of form. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021679 ! cerebellar molecular layer development +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021688 +name: cerebellar molecular layer formation +namespace: biological_process +def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021689 +name: cerebellar molecular layer structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis +relationship: part_of GO:0021698 ! cerebellar cortex structural organization + +[Term] +id: GO:0021690 +name: cerebellar molecular layer maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021679 ! cerebellar molecular layer development +relationship: part_of GO:0021699 ! cerebellar cortex maturation + +[Term] +id: GO:0021691 +name: cerebellar Purkinje cell layer maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development +relationship: part_of GO:0021699 ! cerebellar cortex maturation + +[Term] +id: GO:0021692 +name: cerebellar Purkinje cell layer morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. Morphogenesis pertains to the creation of form. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021693 +name: cerebellar Purkinje cell layer structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis +relationship: part_of GO:0021698 ! cerebellar cortex structural organization + +[Term] +id: GO:0021694 +name: cerebellar Purkinje cell layer formation +namespace: biological_process +def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021695 +name: cerebellar cortex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021696 +name: cerebellar cortex morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021587 ! cerebellum morphogenesis +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021697 +name: cerebellar cortex formation +namespace: biological_process +def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021698 +name: cerebellar cortex structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021699 +name: cerebellar cortex maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021590 ! cerebellum maturation +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021700 +name: developmental maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0021701 +name: cerebellar Golgi cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021684 ! cerebellar granular layer formation + +[Term] +id: GO:0021702 +name: cerebellar Purkinje cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation + +[Term] +id: GO:0021703 +name: locus ceruleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "locus caeruleus development" EXACT [] +synonym: "locus coeruleus development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021704 +name: locus ceruleus morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the locus ceruleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021583 ! pons morphogenesis +relationship: part_of GO:0021703 ! locus ceruleus development + +[Term] +id: GO:0021705 +name: locus ceruleus formation +namespace: biological_process +def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021584 ! pons formation +relationship: part_of GO:0021704 ! locus ceruleus morphogenesis + +[Term] +id: GO:0021706 +name: locus ceruleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021586 ! pons maturation +relationship: part_of GO:0021703 ! locus ceruleus development + +[Term] +id: GO:0021707 +name: cerebellar granule cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021684 ! cerebellar granular layer formation + +[Term] +id: GO:0021708 +name: Lugaro cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021709 +name: cerebellar basket cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021688 ! cerebellar molecular layer formation + +[Term] +id: GO:0021710 +name: cerebellar stellate cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021688 ! cerebellar molecular layer formation + +[Term] +id: GO:0021711 +name: cerebellar unipolar brush cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021684 ! cerebellar granular layer formation + +[Term] +id: GO:0021712 +name: candelabrum cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation + +[Term] +id: GO:0021713 +name: inferior olivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "inferior olive development" RELATED [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021714 +name: inferior olivary nucleus morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the inferior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "inferior olive morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021579 ! medulla oblongata morphogenesis +relationship: part_of GO:0021713 ! inferior olivary nucleus development + +[Term] +id: GO:0021715 +name: inferior olivary nucleus formation +namespace: biological_process +def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "inferior olive biosynthesis" RELATED [] +synonym: "inferior olive formation" RELATED [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021580 ! medulla oblongata formation +relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis + +[Term] +id: GO:0021716 +name: inferior olivary nucleus structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "inferior olive structural organization" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021581 ! medulla oblongata structural organization +relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis + +[Term] +id: GO:0021717 +name: inferior olivary nucleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "inferior olive maturation" RELATED [] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021582 ! medulla oblongata maturation +relationship: part_of GO:0021713 ! inferior olivary nucleus development + +[Term] +id: GO:0021718 +name: superior olivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "superior olive development" RELATED [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021719 +name: superior olivary nucleus morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the superior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "superior olive morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021583 ! pons morphogenesis +relationship: part_of GO:0021718 ! superior olivary nucleus development + +[Term] +id: GO:0021720 +name: superior olivary nucleus formation +namespace: biological_process +def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021584 ! pons formation +relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis + +[Term] +id: GO:0021721 +name: superior olivary nucleus structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021585 ! pons structural organization +relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis + +[Term] +id: GO:0021722 +name: superior olivary nucleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343] +comment: This term was added by GO_REF:0000021. +synonym: "superior olive maturation" RELATED [] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0021586 ! pons maturation +relationship: part_of GO:0021718 ! superior olivary nucleus development + +[Term] +id: GO:0021723 +name: rhombencephalic reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the reticular formation over time, from its formation to the mature structure. The reticular formation is a series of brain nuclei located in the medulla oblongata." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021724 +name: inferior raphe nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! rhombencephalic reticular formation development + +[Term] +id: GO:0021725 +name: superior raphe nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! rhombencephalic reticular formation development + +[Term] +id: GO:0021726 +name: lateral reticular nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! rhombencephalic reticular formation development + +[Term] +id: GO:0021727 +name: intermediate reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021723 ! rhombencephalic reticular formation development + +[Term] +id: GO:0021728 +name: inferior reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021723 ! rhombencephalic reticular formation development + +[Term] +id: GO:0021729 +name: superior reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021723 ! rhombencephalic reticular formation development + +[Term] +id: GO:0021730 +name: trigeminal sensory nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0021731 +name: trigeminal motor nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021732 +name: midbrain-hindbrain boundary maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513] +comment: This term was added by GO_REF:0000021. +synonym: "isthmus maturation" RELATED [] +synonym: "MHB maturation" RELATED [] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development + +[Term] +id: GO:0021735 +name: dentate nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021736 +name: globose nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021737 +name: emboliform nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021738 +name: fastigial nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021739 +name: mesencephalic trigeminal nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021730 ! trigeminal sensory nucleus development + +[Term] +id: GO:0021740 +name: pontine nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021730 ! trigeminal sensory nucleus development + +[Term] +id: GO:0021741 +name: spinal trigeminal nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021730 ! trigeminal sensory nucleus development + +[Term] +id: GO:0021742 +name: abducens nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021743 +name: hypoglossal nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021744 +name: dorsal motor nucleus of vagus nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021745 +name: nucleus ambiguus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021746 +name: solitary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021747 +name: cochlear nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021748 +name: dorsal cochlear nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021747 ! cochlear nucleus development + +[Term] +id: GO:0021749 +name: ventral cochlear nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021747 ! cochlear nucleus development + +[Term] +id: GO:0021750 +name: vestibular nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021751 +name: salivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021752 +name: inferior salivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021751 ! salivary nucleus development + +[Term] +id: GO:0021753 +name: superior salivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021751 ! salivary nucleus development + +[Term] +id: GO:0021754 +name: facial nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021755 +name: eurydendroid cell differentiation +namespace: biological_process +def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15892096] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021756 +name: striatum development +namespace: biological_process +def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0021757 +name: caudate nucleus development +namespace: biological_process +def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021756 ! striatum development + +[Term] +id: GO:0021758 +name: putamen development +namespace: biological_process +def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021756 ! striatum development + +[Term] +id: GO:0021759 +name: globus pallidus development +namespace: biological_process +def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +synonym: "pallidum development" EXACT [PMID:16271465] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021761 +name: limbic system development +namespace: biological_process +def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048731 ! system development +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021762 +name: substantia nigra development +namespace: biological_process +def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021539 ! subthalamus development + +[Term] +id: GO:0021763 +name: subthalamic nucleus development +namespace: biological_process +def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +synonym: "corpus luysi development" RELATED [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021539 ! subthalamus development + +[Term] +id: GO:0021764 +name: amygdala development +namespace: biological_process +def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021765 +name: cingulate gyrus development +namespace: biological_process +def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021766 +name: hippocampus development +namespace: biological_process +def: "The progression of the hippocampus over time from its initial formation until its mature state." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021543 ! pallium development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021767 +name: mammilary body development +namespace: biological_process +def: "The progression of the mammilary body over time from its initial formation until its mature state. The mammilary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +synonym: "mammillary body development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021768 +name: nucleus accumbens development +namespace: biological_process +def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +synonym: "accumbens nucleus development" EXACT [GOC:dgh] +synonym: "ventral striatum development" BROAD [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021756 ! striatum development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021769 +name: orbitofrontal cortex development +namespace: biological_process +def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021770 +name: parahippocampal gyrus development +namespace: biological_process +def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +synonym: "hippocampal gyrus" EXACT [GOC:dgh] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021771 +name: lateral geniculate nucleus development +namespace: biological_process +def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +synonym: "LGN development" EXACT [GOC:dgh] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021794 ! thalamus development + +[Term] +id: GO:0021772 +name: olfactory bulb development +namespace: biological_process +def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021988 ! olfactory lobe development + +[Term] +id: GO:0021773 +name: striatal medium spiny neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021879 ! forebrain neuron differentiation +relationship: part_of GO:0021756 ! striatum development + +[Term] +id: GO:0021774 +name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification + +[Term] +id: GO:0021775 +name: smoothened signaling pathway involved in ventral spinal cord interneuron specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] +is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning +relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification + +[Term] +id: GO:0021776 +name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15936325] +comment: This term was added by GO_REF:0000021. +synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT [] +is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning +relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification + +[Term] +id: GO:0021777 +name: BMP signaling pathway involved in spinal cord association neuron specification +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981] +comment: This term was added by GO_REF:0000021. +synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT [] +synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [] +synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [] +is_a: GO:0021919 ! BMP signaling pathway in spinal cord dorsal-ventral patterning +relationship: part_of GO:0021519 ! spinal cord association neuron specification + +[Term] +id: GO:0021778 +name: oligodendrocyte cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021780 ! glial cell fate specification +relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment + +[Term] +id: GO:0021779 +name: oligodendrocyte cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021781 ! glial cell fate commitment +is_a: GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0021780 +name: glial cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0021781 ! glial cell fate commitment + +[Term] +id: GO:0021781 +name: glial cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0021782 +name: glial cell development +namespace: biological_process +def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048468 ! cell development +relationship: part_of GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0021783 +name: preganglionic parasympathetic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048731 ! system development +relationship: part_of GO:0007417 ! central nervous system development +relationship: part_of GO:0048486 ! parasympathetic nervous system development + +[Term] +id: GO:0021784 +name: postganglionic parasympathetic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048731 ! system development +relationship: part_of GO:0007422 ! peripheral nervous system development +relationship: part_of GO:0048486 ! parasympathetic nervous system development + +[Term] +id: GO:0021785 +name: branchiomotor neuron axon guidance +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +synonym: "BMN axon guidance" EXACT [PMID:14699587] +synonym: "branchial motor axon guidance" EXACT [PMID:14699587] +synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587] +is_a: GO:0008045 ! motor axon guidance + +[Term] +id: GO:0021786 +name: branchiomotor neuron axon guidance in the neural tube +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021787 +name: chemorepulsion of branchiomotor neuron axon in neural tube +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021786 ! branchiomotor neuron axon guidance in the neural tube +is_a: GO:0021793 ! chemorepulsion of branchiomotor axon + +[Term] +id: GO:0021788 +name: chemoattraction of branchiomotor neuron axon in neural tube +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021786 ! branchiomotor neuron axon guidance in the neural tube +is_a: GO:0021792 ! chemoattraction of branchiomotor axon + +[Term] +id: GO:0021789 +name: branchiomotor neuron axon guidance in the branchial arch mesenchyme +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021790 +name: chemorepulsion of branchiomotor axon in branchial arch mesenchyme +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021789 ! branchiomotor neuron axon guidance in the branchial arch mesenchyme +is_a: GO:0021793 ! chemorepulsion of branchiomotor axon + +[Term] +id: GO:0021791 +name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021789 ! branchiomotor neuron axon guidance in the branchial arch mesenchyme +is_a: GO:0021792 ! chemoattraction of branchiomotor axon + +[Term] +id: GO:0021792 +name: chemoattraction of branchiomotor axon +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021793 +name: chemorepulsion of branchiomotor axon +namespace: biological_process +def: "The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021794 +name: thalamus development +namespace: biological_process +def: "The process by which the thalamus changes over time, from its initial formation to its mature state." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021795 +name: cerebral cortex cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022029 ! telencephalon cell migration +relationship: part_of GO:0021987 ! cerebral cortex development + +[Term] +id: GO:0021796 +name: cerebral cortex regionalization +namespace: biological_process +def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "cerebral cortex arealization" EXACT [] +synonym: "cerebral cortex pattern biosynthesis" EXACT [] +synonym: "cerebral cortex pattern formation" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021978 ! telencephalon regionalization +relationship: part_of GO:0021987 ! cerebral cortex development + +[Term] +id: GO:0021797 +name: forebrain anterior/posterior pattern formation +namespace: biological_process +def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "forebrain anterior-posterior pattern formation" EXACT [] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0021871 ! forebrain regionalization + +[Term] +id: GO:0021798 +name: forebrain dorsal/ventral pattern formation +namespace: biological_process +def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "forebrain dorsal-ventral pattern formation" EXACT [] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0021871 ! forebrain regionalization + +[Term] +id: GO:0021799 +name: cerebral cortex radially oriented cell migration +namespace: biological_process +def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021795 ! cerebral cortex cell migration + +[Term] +id: GO:0021800 +name: cerebral cortex tangential migration +namespace: biological_process +def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021795 ! cerebral cortex cell migration + +[Term] +id: GO:0021801 +name: cerebral cortex radial glia guided migration +namespace: biological_process +def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "glial-guided locomotion" RELATED [PMID:12626695] +is_a: GO:0021799 ! cerebral cortex radially oriented cell migration + +[Term] +id: GO:0021802 +name: somal translocation +namespace: biological_process +def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695] +is_a: GO:0021799 ! cerebral cortex radially oriented cell migration + +[Term] +id: GO:0021803 +name: pial surface process extension +namespace: biological_process +def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030031 ! cell projection biogenesis +relationship: part_of GO:0021802 ! somal translocation + +[Term] +id: GO:0021804 +name: negative regulation of cell adhesion in the ventricular zone +namespace: biological_process +def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "down regulation of cell adhesion in the ventricular zone" EXACT [] +synonym: "down-regulation of cell adhesion in the ventricular zone" EXACT [] +synonym: "downregulation of cell adhesion in the ventricular zone" EXACT [] +synonym: "inhibition of cell adhesion in the ventricular zone" NARROW [] +is_a: GO:0007162 ! negative regulation of cell adhesion +relationship: part_of GO:0021802 ! somal translocation + +[Term] +id: GO:0021805 +name: cell movement involved in somal translocation +namespace: biological_process +def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0006928 ! cell motion +relationship: part_of GO:0021802 ! somal translocation + +[Term] +id: GO:0021806 +name: initiation of movement involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph] +is_a: GO:0001667 ! ameboidal cell migration +relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021807 +name: motogenic signaling initiating cell movement in the cerebral cortex +namespace: biological_process +def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT [] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021808 +name: cytosolic calcium signaling involved in the initiation of cell movement in glial-mediated radial cell migration +namespace: biological_process +def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling +relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021809 +name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] +is_a: GO:0021807 ! motogenic signaling initiating cell movement in the cerebral cortex + +[Term] +id: GO:0021810 +name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] +is_a: GO:0021807 ! motogenic signaling initiating cell movement in the cerebral cortex + +[Term] +id: GO:0021811 +name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio] +synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [] +is_a: GO:0021807 ! motogenic signaling initiating cell movement in the cerebral cortex + +[Term] +id: GO:0021812 +name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration + +[Term] +id: GO:0021813 +name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021814 +name: cell motility involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration + +[Term] +id: GO:0021815 +name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021816 +name: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0031269 ! pseudopodium formation +relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021817 +name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] +is_a: GO:0030473 ! nuclear migration along microtubule +relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021818 +name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0030036 ! actin cytoskeleton organization +relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021819 +name: layer formation in the cerebral cortex +namespace: biological_process +def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "cerebral cortex lamination" RELATED [PMID:12626695] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration + +[Term] +id: GO:0021820 +name: organization of extracellular matrix in the marginal zone involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0030198 ! extracellular matrix organization +relationship: part_of GO:0021819 ! layer formation in the cerebral cortex + +[Term] +id: GO:0021821 +name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination +namespace: biological_process +def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] +synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] +synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] +synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +relationship: part_of GO:0021819 ! layer formation in the cerebral cortex + +[Term] +id: GO:0021822 +name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] +synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] +synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] +synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW [] +synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration +relationship: part_of GO:0021819 ! layer formation in the cerebral cortex + +[Term] +id: GO:0021823 +name: cerebral cortex tangential migration using cell-cell interactions +namespace: biological_process +def: "The process whereby neurons interact with each other to promote migration along a tangential plane." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "chain migration" RELATED [PMID:12626695] +is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration + +[Term] +id: GO:0021824 +name: cerebral cortex tangential migration using cell-axon interactions +namespace: biological_process +def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration + +[Term] +id: GO:0021825 +name: substrate-dependent cerebral cortex tangential migration +namespace: biological_process +def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0006929 ! substrate-bound cell migration +is_a: GO:0021800 ! cerebral cortex tangential migration + +[Term] +id: GO:0021826 +name: substrate-independent telencephalic tangential migration +namespace: biological_process +def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022029 ! telencephalon cell migration + +[Term] +id: GO:0021827 +name: postnatal olfactory bulb interneuron migration +namespace: biological_process +def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions +is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb +relationship: part_of GO:0021891 ! olfactory bulb interneuron development + +[Term] +id: GO:0021828 +name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus +namespace: biological_process +alt_id: GO:0021857 +def: "The directional movement of gonadotrophin-releasing hormone producing neurons from the nasal placode to the hypothalamus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021824 ! cerebral cortex tangential migration using cell-axon interactions +is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions +relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development + +[Term] +id: GO:0021829 +name: oligodendrocyte cell migration from the subpallium to the cortex +namespace: biological_process +def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021826 ! substrate-independent telencephalic tangential migration + +[Term] +id: GO:0021830 +name: interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration + +[Term] +id: GO:0021831 +name: embryonic olfactory bulb interneuron precursor migration +namespace: biological_process +def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration +is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb +relationship: part_of GO:0021891 ! olfactory bulb interneuron development + +[Term] +id: GO:0021832 +name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions +namespace: biological_process +def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions + +[Term] +id: GO:0021833 +name: cell-substrate adhesion involved in tangential migration using cell-cell interactions +namespace: biological_process +def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions + +[Term] +id: GO:0021834 +name: chemorepulsion involved in embryonic olfactory bulb interneuron migration +namespace: biological_process +def: "The creation and reception of signals that guide olfactory bulb interneurons down concentration gradients towards the olfactory bulb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration + +[Term] +id: GO:0021835 +name: chemoattraction involved in embryonic olfactory bulb interneuron migration +namespace: biological_process +def: "The creation and reception of signals that result in the migration of interneurons up a concentration gradient towards the olfactory bulb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration + +[Term] +id: GO:0021836 +name: chemorepulsion involved in postnatal olfactory bulb interneuron migration +namespace: biological_process +def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration + +[Term] +id: GO:0021837 +name: motogenic signaling involved in postnatal olfactory bulb interneuron migration +namespace: biological_process +def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT [] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration + +[Term] +id: GO:0021838 +name: motogenic signaling involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT [] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex + +[Term] +id: GO:0021839 +name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The process whereby migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex + +[Term] +id: GO:0021840 +name: directional guidance of interneurons involved in migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030334 ! regulation of cell migration +relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex + +[Term] +id: GO:0021841 +name: chemoattraction involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex + +[Term] +id: GO:0021842 +name: chemorepulsion involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex + +[Term] +id: GO:0021843 +name: substrate-independent telencephalic tangential interneuron migration +namespace: biological_process +def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021826 ! substrate-independent telencephalic tangential migration + +[Term] +id: GO:0021844 +name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration +namespace: biological_process +def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0042330 ! taxis +relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration + +[Term] +id: GO:0021845 +name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration +namespace: biological_process +def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030334 ! regulation of cell migration +relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration + +[Term] +id: GO:0021846 +name: cell proliferation in forebrain +namespace: biological_process +def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021847 +name: neuroblast division in the ventricular zone +namespace: biological_process +def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division + +[Term] +id: GO:0021848 +name: neuroblast division in the subpallium +namespace: biological_process +def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] +is_a: GO:0055057 ! neuroblast division +relationship: part_of GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0021849 +name: neuroblast division in the subventricular zone +namespace: biological_process +def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021873 ! forebrain neuroblast division +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0021850 +name: glioblast cell division in the subpallium +namespace: biological_process +def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "glioblast cell division in the ventral telencephalon" EXACT [PMID:16226447] +is_a: GO:0048860 ! glioblast cell division +relationship: part_of GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0021851 +name: neuroblast division in the dorsal lateral ganglionic eminence +namespace: biological_process +def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021848 ! neuroblast division in the subpallium + +[Term] +id: GO:0021852 +name: pyramidal neuron migration +namespace: biological_process +def: "The migration of pyramidal neuron precursors from the ventricular zone to the correct layer of the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +synonym: "projection neuron migration" RELATED [PMID:12626695] +is_a: GO:0001764 ! neuron migration +is_a: GO:0021801 ! cerebral cortex radial glia guided migration +relationship: part_of GO:0021860 ! pyramidal neuron development + +[Term] +id: GO:0021853 +name: cerebral cortex GABAergic interneuron migration +namespace: biological_process +def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex +relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development + +[Term] +id: GO:0021854 +name: hypothalamus development +namespace: biological_process +def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021855 +name: hypothalamus cell migration +namespace: biological_process +def: "The directed movement of cells into the hypothalamus region of the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0021854 ! hypothalamus development + +[Term] +id: GO:0021856 +name: hypothalamic tangential migration using cell-axon interactions +namespace: biological_process +def: "The movement of hypothalamic neuronal precursors tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021855 ! hypothalamus cell migration + +[Term] +id: GO:0021858 +name: GABAergic neuron differentiation in the basal ganglia +namespace: biological_process +def: "The process whereby a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0021859 +name: pyramidal neuron differentiation +namespace: biological_process +def: "The process whereby a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "projection neuron differentiation" BROAD [PMID:16226447] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0021860 +name: pyramidal neuron development +namespace: biological_process +def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "projection neuron development" BROAD [PMID:16226447] +is_a: GO:0021884 ! forebrain neuron development +relationship: part_of GO:0021859 ! pyramidal neuron differentiation + +[Term] +id: GO:0021861 +name: radial glial cell differentiation in the forebrain +namespace: biological_process +def: "The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0060019 ! radial glial cell differentiation +relationship: part_of GO:0021872 ! generation of neurons in the forebrain + +[Term] +id: GO:0021862 +name: early neuron differentiation in the forebrain +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021863 +name: forebrain neuroblast differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] +synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] +synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] +is_a: GO:0014016 ! neuroblast differentiation +relationship: part_of GO:0021872 ! generation of neurons in the forebrain + +[Term] +id: GO:0021864 +name: radial glial cell division in the forebrain +namespace: biological_process +def: "The mitotic division of radial glial cells in the developing forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0051301 ! cell division +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0021865 +name: symmetric radial glial cell division in the forebrain +namespace: biological_process +def: "The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021864 ! radial glial cell division in the forebrain + +[Term] +id: GO:0021866 +name: asymmetric radial glial cell division in the forebrain +namespace: biological_process +def: "The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021864 ! radial glial cell division in the forebrain + +[Term] +id: GO:0021867 +name: neuron-producing asymmetric radial glial cell division in the forebrain +namespace: biological_process +def: "The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021866 ! asymmetric radial glial cell division in the forebrain + +[Term] +id: GO:0021868 +name: ventricular zone cell-producing asymmetric radial glial cell division in the forebrain +namespace: biological_process +def: "The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021866 ! asymmetric radial glial cell division in the forebrain + +[Term] +id: GO:0021869 +name: forebrain ventricular zone progenitor cell division +namespace: biological_process +def: "The mitotic division of a basal progenitor giving rise to two neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0051301 ! cell division +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0021870 +name: Cajal-Retzius cell differentiation +namespace: biological_process +def: "The process whereby a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021895 ! cerebral cortex neuron differentiation + +[Term] +id: GO:0021871 +name: forebrain regionalization +namespace: biological_process +def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021872 +name: generation of neurons in the forebrain +namespace: biological_process +def: "The process by which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048699 ! generation of neurons +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021873 +name: forebrain neuroblast division +namespace: biological_process +def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast. As in, but not restricted to, the vertebrates (Vertebrata, ncbi_taxonomy_id:7742)." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0055057 ! neuroblast division +relationship: part_of GO:0021872 ! generation of neurons in the forebrain + +[Term] +id: GO:0021874 +name: Wnt receptor signaling pathway in forebrain neuroblast division +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT [] +is_a: GO:0016055 ! Wnt receptor signaling pathway +relationship: part_of GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021875 +name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021876 +name: Notch signaling pathway in forebrain neuroblast division +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT [] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021877 +name: forebrain neuron fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021878 +name: forebrain astrocyte fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0060018 ! astrocyte fate commitment +relationship: part_of GO:0021896 ! forebrain astrocyte differentiation + +[Term] +id: GO:0021879 +name: forebrain neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021872 ! generation of neurons in the forebrain + +[Term] +id: GO:0021880 +name: Notch signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0021881 +name: Wnt receptor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0016055 ! Wnt receptor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0021882 +name: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0021883 +name: cell cycle arrest of committed forebrain neuronal progenitor cell +namespace: biological_process +def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007050 ! cell cycle arrest +relationship: part_of GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021884 +name: forebrain neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021954 ! central nervous system neuron development +relationship: part_of GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021885 +name: forebrain cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another at least one of which is located in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021886 +name: hypothalamus gonadotrophin-releasing hormone neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021979 ! hypothalamus cell differentiation + +[Term] +id: GO:0021887 +name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation + +[Term] +id: GO:0021888 +name: hypothalamus gonadotrophin-releasing hormone neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021884 ! forebrain neuron development +relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation + +[Term] +id: GO:0021889 +name: olfactory bulb interneuron differentiation +namespace: biological_process +def: "The process whereby a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021772 ! olfactory bulb development + +[Term] +id: GO:0021890 +name: olfactory bulb interneuron fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation + +[Term] +id: GO:0021891 +name: olfactory bulb interneuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation + +[Term] +id: GO:0021892 +name: cerebral cortex GABAergic interneuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021895 ! cerebral cortex neuron differentiation + +[Term] +id: GO:0021893 +name: cerebral cortex GABAergic interneuron fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation + +[Term] +id: GO:0021894 +name: cerebral cortex GABAergic interneuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021954 ! central nervous system neuron development +relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation + +[Term] +id: GO:0021895 +name: cerebral cortex neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021896 +name: forebrain astrocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048708 ! astrocyte differentiation +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021897 +name: forebrain astrocyte development +namespace: biological_process +def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0014002 ! astrocyte development +relationship: part_of GO:0021896 ! forebrain astrocyte differentiation + +[Term] +id: GO:0021898 +name: commitment of multipotent stem cells to the neuronal lineage in the forebrain +namespace: biological_process +def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021877 ! forebrain neuron fate commitment + +[Term] +id: GO:0021899 +name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0021900 +name: ventricular zone cell fate commitment +namespace: biological_process +def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain +relationship: part_of GO:0021863 ! forebrain neuroblast differentiation + +[Term] +id: GO:0021901 +name: early neuron fate commitment in the forebrain +namespace: biological_process +def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain +relationship: part_of GO:0021862 ! early neuron differentiation in the forebrain + +[Term] +id: GO:0021902 +name: commitment of a neuronal cell to a specific type of neuron in the forebrain +namespace: biological_process +def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021877 ! forebrain neuron fate commitment + +[Term] +id: GO:0021903 +name: rostrocaudal neural tube patterning +namespace: biological_process +def: "The process by which the neural tube is divided into specific regions along the rostrocaudal axis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0021532 ! neural tube patterning + +[Term] +id: GO:0021904 +name: dorsoventral neural tube patterning +namespace: biological_process +def: "The process by which the neural tube is regionalized in the dorsoventral axis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "dorsal ventral neural tube patterning" EXACT [GOC:dph] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0021532 ! neural tube patterning + +[Term] +id: GO:0021905 +name: forebrain-midbrain boundary formation +namespace: biological_process +def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0021906 +name: hindbrain-spinal cord boundary formation +namespace: biological_process +def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0021907 +name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior-posterior patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021908 +name: retinoic acid receptor signaling pathway in spinal cord anterior-posterior patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021909 +name: regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021910 +name: smoothened signaling pathway involved in ventral spinal cord patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT [] +is_a: GO:0007224 ! smoothened signaling pathway +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning + +[Term] +id: GO:0021911 +name: retinoic acid metabolic process in spinal cord anterior-posterior patterning +namespace: biological_process +def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT [] +is_a: GO:0042573 ! retinoic acid metabolic process +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021912 +name: regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification + +[Term] +id: GO:0021913 +name: regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification + +[Term] +id: GO:0021914 +name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] +synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] +synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] +synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW [] +synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT [] +is_a: GO:0045879 ! negative regulation of smoothened signaling pathway +relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning + +[Term] +id: GO:0021915 +name: neural tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007399 ! nervous system development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0021916 +name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors +namespace: biological_process +def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0021917 ! somatic motor neuron fate commitment + +[Term] +id: GO:0021917 +name: somatic motor neuron fate commitment +namespace: biological_process +def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021523 ! somatic motor neuron differentiation + +[Term] +id: GO:0021918 +name: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0021917 ! somatic motor neuron fate commitment + +[Term] +id: GO:0021919 +name: BMP signaling pathway in spinal cord dorsal-ventral patterning +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981] +comment: This term was added by GO_REF:0000021. +synonym: "BMP signalling pathway in spinal cord dorsal-ventral patterning" EXACT [] +synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT [] +synonym: "bone morphogenetic protein signalling pathway in spinal cord dorsal-ventral patterning" EXACT [] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0021914 ! negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning + +[Term] +id: GO:0021920 +name: regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0021519 ! spinal cord association neuron specification + +[Term] +id: GO:0021921 +name: regulation of cell proliferation in dorsal spinal cord +namespace: biological_process +def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0042127 ! regulation of cell proliferation +relationship: part_of GO:0021516 ! dorsal spinal cord development +relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord + +[Term] +id: GO:0021922 +name: Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981] +comment: This term was added by GO_REF:0000021. +synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] +is_a: GO:0016055 ! Wnt receptor signaling pathway +relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord + +[Term] +id: GO:0021923 +name: cell proliferation in the hindbrain ventricular zone +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021534 ! cell proliferation in hindbrain + +[Term] +id: GO:0021924 +name: cell proliferation in the external granule layer +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021534 ! cell proliferation in hindbrain + +[Term] +id: GO:0021925 +name: Purkinje cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone + +[Term] +id: GO:0021926 +name: Golgi cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone + +[Term] +id: GO:0021927 +name: deep nuclear neuron precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone + +[Term] +id: GO:0021928 +name: basket cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone + +[Term] +id: GO:0021929 +name: stellate cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone + +[Term] +id: GO:0021930 +name: granule cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021924 ! cell proliferation in the external granule layer + +[Term] +id: GO:0021931 +name: rostral hindbrain neuronal precursor cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021924 ! cell proliferation in the external granule layer + +[Term] +id: GO:0021932 +name: hindbrain radial glia guided cell migration +namespace: biological_process +def: "The radially directed movement of cells along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021535 ! cell migration in hindbrain + +[Term] +id: GO:0021933 +name: radial glia guided migration of granule cell +namespace: biological_process +def: "The inward migration of postmitotic granule cells along radial glial cells from the external granule layer to the internal granule cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021934 +name: hindbrain tangential cell migration +namespace: biological_process +def: "The migration of cells in the hindbrain in which cells move orthogonal to the direction of radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725] +is_a: GO:0021535 ! cell migration in hindbrain + +[Term] +id: GO:0021935 +name: granule cell precursor tangential migration +namespace: biological_process +def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021934 ! hindbrain tangential cell migration + +[Term] +id: GO:0021936 +name: regulation of granule cell precursor proliferation +namespace: biological_process +def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0042127 ! regulation of cell proliferation +is_a: GO:0051960 ! regulation of nervous system development +relationship: regulates GO:0021930 ! granule cell precursor proliferation + +[Term] +id: GO:0021937 +name: Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation +namespace: biological_process +def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0021940 ! positive regulation of granule cell precursor proliferation + +[Term] +id: GO:0021938 +name: smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in granule cells that contributes to the regulation of proliferation of the cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT [] +is_a: GO:0007224 ! smoothened signaling pathway +relationship: part_of GO:0021937 ! Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation + +[Term] +id: GO:0021939 +name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation +namespace: biological_process +def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT [] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0021941 ! negative regulation of granule cell precursor proliferation + +[Term] +id: GO:0021940 +name: positive regulation of granule cell precursor proliferation +namespace: biological_process +def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "activation of granule cell precursor proliferation" NARROW [] +synonym: "stimulation of granule cell precursor proliferation" NARROW [] +synonym: "up regulation of granule cell precursor proliferation" EXACT [] +synonym: "up-regulation of granule cell precursor proliferation" EXACT [] +synonym: "upregulation of granule cell precursor proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0021936 ! regulation of granule cell precursor proliferation +relationship: positively_regulates GO:0021930 ! granule cell precursor proliferation + +[Term] +id: GO:0021941 +name: negative regulation of granule cell precursor proliferation +namespace: biological_process +def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "down regulation of granule cell precursor proliferation" EXACT [] +synonym: "down-regulation of granule cell precursor proliferation" EXACT [] +synonym: "downregulation of granule cell precursor proliferation" EXACT [] +synonym: "inhibition of granule cell precursor proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0021936 ! regulation of granule cell precursor proliferation +relationship: negatively_regulates GO:0021930 ! granule cell precursor proliferation + +[Term] +id: GO:0021942 +name: radial glia guided migration of Purkinje cell +namespace: biological_process +def: "The migration of postmitotic Purkinje cells along radial glial cells from the ventricular zone to the Purkinje cell layer." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021943 +name: formation of radial glial scaffolds +namespace: biological_process +def: "The formation of scaffolds from radial glial cells. The scaffolds are used as a substrate for the radial migration of cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725] +synonym: "Bergmann fiber formation" RELATED [PMID:15157725] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021944 +name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration +namespace: biological_process +def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of hindbrain glial-mediated radial cell migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021945 +name: positive regulation of granule cell migration by calcium +namespace: biological_process +def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:15157725] +comment: This term was added by GO_REF:0000021. +synonym: "calcium-mediated activation of granule cell migration" NARROW [] +synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb] +synonym: "calcium-mediated stimulation of granule cell migration" NARROW [] +synonym: "calcium-mediated up regulation of granule cell migration" EXACT [] +synonym: "calcium-mediated up-regulation of granule cell migration" EXACT [] +synonym: "calcium-mediated upregulation of granule cell migration" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0030335 ! positive regulation of cell migration +relationship: part_of GO:0021933 ! radial glia guided migration of granule cell + +[Term] +id: GO:0021946 +name: deep nuclear neuron cell migration +namespace: biological_process +def: "The directed movement of deep nuclear neurons from the ventricular zone to the deep hindbrain nuclei." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021535 ! cell migration in hindbrain + +[Term] +id: GO:0021947 +name: outward migration of deep nuclear neurons +namespace: biological_process +def: "The directed movement of deep nuclear neurons from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0001764 ! neuron migration +relationship: part_of GO:0021946 ! deep nuclear neuron cell migration + +[Term] +id: GO:0021948 +name: inward migration of deep nuclear neurons +namespace: biological_process +def: "The directed movement of deep nuclear neurons from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0001764 ! neuron migration +relationship: part_of GO:0021946 ! deep nuclear neuron cell migration + +[Term] +id: GO:0021949 +name: brainstem precerebellar neuron precursor migration +namespace: biological_process +def: "The early migration of precerebellar neuronal precursors in which cells move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021934 ! hindbrain tangential cell migration + +[Term] +id: GO:0021950 +name: chemorepulsion involved in precerebellar neuron migration +namespace: biological_process +def: "The creation and reception of signals that repel precerebellar neurons as a component of the process of tangential migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration + +[Term] +id: GO:0021951 +name: chemoattraction involved in precerebellar neuron migration +namespace: biological_process +def: "The creation and reception of signals that guide precerebellar neurons towards their signals, where this process is involved in tangential migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration + +[Term] +id: GO:0021952 +name: central nervous system projection neuron axonogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "central nervous system axon tract development" NARROW [GOC:dph] +is_a: GO:0021955 ! central nervous system neuron axonogenesis + +[Term] +id: GO:0021953 +name: central nervous system neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021954 +name: central nervous system neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0021953 ! central nervous system neuron differentiation + +[Term] +id: GO:0021955 +name: central nervous system neuron axonogenesis +namespace: biological_process +def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007409 ! axonogenesis +relationship: part_of GO:0021954 ! central nervous system neuron development + +[Term] +id: GO:0021956 +name: central nervous system interneuron axonogenesis +namespace: biological_process +def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021955 ! central nervous system neuron axonogenesis + +[Term] +id: GO:0021957 +name: corticospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731] +synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021958 +name: gracilis tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12867698] +comment: This term was added by GO_REF:0000021. +synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021959 +name: cuneatus tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12867698] +comment: This term was added by GO_REF:0000021. +synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021960 +name: anterior commissure morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021961 +name: posterior commissure morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021962 +name: vestibulospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021963 +name: spinothalamic tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT [] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021964 +name: rubrospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021965 +name: spinal cord ventral commissure morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the spinal cord ventral commissure are generated and organized. Morphogenesis pertains to the creation of form." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021966 +name: corticospinal neuron axon guidance +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021957 ! corticospinal tract morphogenesis + +[Term] +id: GO:0021967 +name: corticospinal neuron axon neuron guidance through the cerebral cortex +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021968 +name: corticospinal neuron axon guidance through the internal capsule +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021969 +name: corticospinal neuron axon guidance through the cerebral peduncle +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021970 +name: corticospinal neuron axon guidance through the basilar pons +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021971 +name: corticospinal neuron axon guidance through the medullary pyramid +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021972 +name: corticospinal neuron axon guidance through the spinal cord +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021973 +name: corticospinal neuron axon decussation +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016199 ! axon midline choice point recognition +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021974 +name: trigeminothalamic tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021975 +name: pons reticulospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021976 +name: medulla reticulospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021977 +name: tectospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021978 +name: telencephalon regionalization +namespace: biological_process +def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mgi_curators, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021871 ! forebrain regionalization + +[Term] +id: GO:0021979 +name: hypothalamus cell differentiation +namespace: biological_process +def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mgi_curators, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021854 ! hypothalamus development + +[Term] +id: GO:0021980 +name: subpallium cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another in the subpallium." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022029 ! telencephalon cell migration +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0021981 +name: subpallium radially oriented migration +namespace: biological_process +def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021980 ! subpallium cell migration + +[Term] +id: GO:0021982 +name: pineal gland development +namespace: biological_process +def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "epiphysis development" EXACT [GOC:dph] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0021983 +name: pituitary gland development +namespace: biological_process +def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "hypophysis development" RELATED [GOC:dph] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0021984 +name: adenohypophysis development +namespace: biological_process +def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "adenophysis development" EXACT [] +synonym: "anterior pituitary development" EXACT [] +synonym: "anterior pituitary gland development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021983 ! pituitary gland development + +[Term] +id: GO:0021985 +name: neurohypophysis development +namespace: biological_process +def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "neurophysis development" EXACT [] +synonym: "posterior pituitary development" EXACT [] +synonym: "posterior pituitary gland development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021983 ! pituitary gland development + +[Term] +id: GO:0021986 +name: habenula development +namespace: biological_process +def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:9780721601465] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021538 ! epithalamus development + +[Term] +id: GO:0021987 +name: cerebral cortex development +namespace: biological_process +def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "neocortex development" RELATED [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021543 ! pallium development + +[Term] +id: GO:0021988 +name: olfactory lobe development +namespace: biological_process +def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021989 +name: olfactory cortex development +namespace: biological_process +def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021988 ! olfactory lobe development + +[Term] +id: GO:0021990 +name: neural plate formation +namespace: biological_process +def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0001839 ! neural plate morphogenesis + +[Term] +id: GO:0021991 +name: neural plate thickening +namespace: biological_process +def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +relationship: part_of GO:0001839 ! neural plate morphogenesis + +[Term] +id: GO:0021992 +name: cell proliferation involved in neural plate elongation +namespace: biological_process +def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0014022 ! neural plate elongation + +[Term] +id: GO:0021993 +name: initiation of neural tube closure +namespace: biological_process +def: "The process by which closure points are established at multiple points and along the neural rostrocaudal axis." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0021994 +name: progression of neural tube closure +namespace: biological_process +def: "The process whereby the neural folds are fused extending from the initial closure points." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0021995 +name: neuropore closure +namespace: biological_process +def: "The process of joining together the neural folds at either end of the neural tube." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0021996 +name: lamina terminalis formation +namespace: biological_process +def: "The process whereby the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021506 ! anterior neuropore closure + +[Term] +id: GO:0021997 +name: neural plate pattern formation +namespace: biological_process +def: "The pattern specification process whereby the axes of the nervous system are established." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0001840 ! neural plate development + +[Term] +id: GO:0021998 +name: neural plate mediolateral pattern formation +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021997 ! neural plate pattern formation + +[Term] +id: GO:0021999 +name: neural plate anterioposterior pattern formation +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021997 ! neural plate pattern formation + +[Term] +id: GO:0022000 +name: forebrain induction by the anterior neural ridge +namespace: biological_process +def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0031128 ! induction +relationship: part_of GO:0021999 ! neural plate anterioposterior pattern formation + +[Term] +id: GO:0022001 +name: negative regulation of anterior neural cell fate commitment of the neural plate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb] +comment: This term was added by GO_REF:0000021. +synonym: "caudalization of neural plate" EXACT [] +synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW [] +synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] +synonym: "posteriorization" BROAD [] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0051961 ! negative regulation of nervous system development +relationship: part_of GO:0021999 ! neural plate anterioposterior pattern formation + +[Term] +id: GO:0022002 +name: Wnt receptor signaling pathway involved in negative regulation of anterior neural cell fate commitment of the neural plate +namespace: biological_process +def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb] +comment: This term was added by GO_REF:0000021. +synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] +synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] +synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] +is_a: GO:0016055 ! Wnt receptor signaling pathway +is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate + +[Term] +id: GO:0022003 +name: fibroblast growth factor receptor signaling pathway involved in negative regulation of anterior neural cell fate commitment of the neural plate +namespace: biological_process +def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb] +comment: This term was added by GO_REF:0000021. +synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] +synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] +synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate + +[Term] +id: GO:0022004 +name: midbrain-hindbrain boundary maturation during brain development +namespace: biological_process +def: "A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0007420 ! brain development +relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation + +[Term] +id: GO:0022005 +name: midbrain-hindbrain boundary maturation during neural plate development +namespace: biological_process +def: "A developmental process involved in neural plate development. This process is independent of morphogenetic (shape) change, and is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0001840 ! neural plate development +relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation + +[Term] +id: GO:0022006 +name: zona limitans intrathalamica formation +namespace: biological_process +def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11425897, PMID:16452095] +comment: This term was added by GO_REF:0000021. +synonym: "zli biosynthesis" EXACT [] +synonym: "zli formation" EXACT [] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0022007 +name: convergent extension involved in neural plate elongation +namespace: biological_process +def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] +comment: This term was added by GO_REF:0000021. +is_a: GO:0016477 ! cell migration +is_a: GO:0060026 ! convergent extension +relationship: part_of GO:0014022 ! neural plate elongation + +[Term] +id: GO:0022008 +name: neurogenesis +namespace: biological_process +def: "Generation of cells within the nervous system." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "nervous system cell generation" EXACT systematic_synonym [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0022009 +name: central nervous system vasculogenesis +namespace: biological_process +def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0001570 ! vasculogenesis +relationship: part_of GO:0014045 ! establishment of blood-brain barrier + +[Term] +id: GO:0022010 +name: myelination in the central nervous system +namespace: biological_process +def: "The process whereby neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "central nervous system myelination" EXACT [] +is_a: GO:0032291 ! ensheathment of axons in the central nervous system +is_a: GO:0042552 ! myelination +relationship: part_of GO:0014003 ! oligodendrocyte development + +[Term] +id: GO:0022011 +name: myelination in the peripheral nervous system +namespace: biological_process +def: "The process whereby neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "peripheral nervous system myelination" EXACT [] +is_a: GO:0032292 ! ensheathment of axons in the peripheral nervous system +is_a: GO:0042552 ! myelination +relationship: part_of GO:0014044 ! Schwann cell development + +[Term] +id: GO:0022012 +name: subpallium cell proliferation in the forebrain +namespace: biological_process +def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021846 ! cell proliferation in forebrain +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0022013 +name: pallium cell proliferation in the forebrain +namespace: biological_process +def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021846 ! cell proliferation in forebrain +relationship: part_of GO:0021543 ! pallium development + +[Term] +id: GO:0022014 +name: radial glial cell division in the subpallium +namespace: biological_process +def: "The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021864 ! radial glial cell division in the forebrain +relationship: part_of GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0022015 +name: radial glial cell division in the pallium +namespace: biological_process +def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0051301 ! cell division +relationship: part_of GO:0022013 ! pallium cell proliferation in the forebrain + +[Term] +id: GO:0022016 +name: glioblast cell division in the pallium +namespace: biological_process +def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048860 ! glioblast cell division +relationship: part_of GO:0022013 ! pallium cell proliferation in the forebrain + +[Term] +id: GO:0022017 +name: neuroblast division in the pallium +namespace: biological_process +def: "The division of neuroblast in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0017145 ! stem cell division +relationship: part_of GO:0022013 ! pallium cell proliferation in the forebrain + +[Term] +id: GO:0022018 +name: lateral ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0022019 +name: dorsal lateral ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022012 ! subpallium cell proliferation in the forebrain +relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation + +[Term] +id: GO:0022020 +name: medial ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0022021 +name: caudal ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0022022 +name: septal cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "septum cell proliferation" EXACT [] +is_a: GO:0022012 ! subpallium cell proliferation in the forebrain + +[Term] +id: GO:0022023 +name: radial glial cell fate commitment in the forebrain +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain +relationship: part_of GO:0021861 ! radial glial cell differentiation in the forebrain + +[Term] +id: GO:0022024 +name: BMP signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT [] +synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT [] +synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0022025 +name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0022026 +name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain + +[Term] +id: GO:0022027 +name: interkinetic nuclear migration +namespace: biological_process +def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0051647 ! nucleus localization +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0022028 +name: tangential migration from the subventricular zone to the olfactory bulb +namespace: biological_process +def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "rostral migratory stream migration" EXACT [] +is_a: GO:0022029 ! telencephalon cell migration +relationship: part_of GO:0021772 ! olfactory bulb development + +[Term] +id: GO:0022029 +name: telencephalon cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another at least one of which is located in the telencephalon." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021885 ! forebrain cell migration +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0022030 +name: telencephalon glial cell migration +namespace: biological_process +def: "The orderly movement of glial cells through the telencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022029 ! telencephalon cell migration + +[Term] +id: GO:0022031 +name: telencephalon astrocyte cell migration +namespace: biological_process +def: "The orderly movement of astrocyte cells through the telencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0022032 +name: telencephalon oligodendrocyte cell migration +namespace: biological_process +def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0022033 +name: telencephalon microglial cell migration +namespace: biological_process +def: "The orderly movement of microglial cells through the telencephalon." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0022034 +name: rhombomere cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0022035 +name: rhombomere cell migration +namespace: biological_process +def: "The movement of cells within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15629700] +comment: This term was added by GO_REF:0000021. +is_a: GO:0021535 ! cell migration in hindbrain +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0022036 +name: rhombomere cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0022037 +name: metencephalon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0022038 +name: corpus callosum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0022400 +name: regulation of rhodopsin mediated signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah] +synonym: "regulation of rhodopsin mediated signalling" EXACT [] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway + +[Term] +id: GO:0022401 +name: adaptation of signaling pathway +namespace: biological_process +def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete] +synonym: "adaptation of signal transduction pathway" EXACT [] +synonym: "adaptation of signalling pathway" EXACT [] +synonym: "desensitization of signaling pathway" EXACT [] +synonym: "desensitization of signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction + +[Term] +id: GO:0022402 +name: cell cycle process +namespace: biological_process +def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0007049 ! cell cycle + +[Term] +id: GO:0022403 +name: cell cycle phase +namespace: biological_process +def: "A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events." [GOC:isa_complete] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0022404 +name: molting cycle process +namespace: biological_process +def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete] +is_a: GO:0042303 ! molting cycle + +[Term] +id: GO:0022405 +name: hair cycle process +namespace: biological_process +def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0042633 ! hair cycle + +[Term] +id: GO:0022406 +name: membrane docking +namespace: biological_process +def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0022407 +name: regulation of cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0022408 +name: negative regulation of cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] +synonym: "down regulation of cell-cell adhesion" EXACT [] +synonym: "down-regulation of cell-cell adhesion" EXACT [] +synonym: "downregulation of cell-cell adhesion" EXACT [] +synonym: "inhibition of cell-cell adhesion" NARROW [] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: negatively_regulates GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0022409 +name: positive regulation of cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] +synonym: "activation of cell-cell adhesion" NARROW [] +synonym: "stimulation of cell-cell adhesion" NARROW [] +synonym: "up regulation of cell-cell adhesion" EXACT [] +synonym: "up-regulation of cell-cell adhesion" EXACT [] +synonym: "upregulation of cell-cell adhesion" EXACT [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:0045785 ! positive regulation of cell adhesion +relationship: positively_regulates GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0022410 +name: circadian sleep/wake cycle process +namespace: biological_process +def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete] +is_a: GO:0048512 ! circadian behavior +relationship: part_of GO:0042745 ! circadian sleep/wake cycle + +[Term] +id: GO:0022411 +name: cellular component disassembly +namespace: biological_process +def: "A cellular process that results in the breakdown of a part of the cell." [GOC:isa_complete] +subset: goslim_pir +subset: gosubset_prok +synonym: "cell structure disassembly" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0022412 +name: reproductive cellular process in multicellular organism +namespace: biological_process +def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] +is_a: GO:0048610 ! reproductive cellular process + +[Term] +id: GO:0022413 +name: reproductive process in single-celled organism +namespace: biological_process +def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0048610 ! reproductive cellular process +relationship: part_of GO:0032505 ! reproduction of a single-celled organism + +[Term] +id: GO:0022414 +name: reproductive process +namespace: biological_process +def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0008150 ! biological_process +relationship: part_of GO:0000003 ! reproduction + +[Term] +id: GO:0022415 +name: viral reproductive process +namespace: biological_process +def: "A reproductive process involved in viral reproduction. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:isa_complete] +synonym: "viral life cycle process" EXACT [] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0016032 ! viral reproduction + +[Term] +id: GO:0022416 +name: bristle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bristle over time, from its formation to the mature structure. A bristle is an insect sensory organ." [GOC:isa_complete] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0022417 +name: protein maturation via protein folding +namespace: biological_process +def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete] +is_a: GO:0006457 ! protein folding +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0022600 +name: digestive system process +namespace: biological_process +def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jic, GOC:mtg_cardio] +is_a: GO:0003008 ! system process +relationship: part_of GO:0007586 ! digestion + +[Term] +id: GO:0022601 +name: menstrual cycle phase +namespace: biological_process +def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jic] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0048731 ! system development + +[Term] +id: GO:0022602 +name: ovulation cycle process +namespace: biological_process +def: "A process involved in the sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete] +synonym: "estrous cycle process" RELATED [] +synonym: "menstrual cycle process" RELATED [] +is_a: GO:0048511 ! rhythmic process +relationship: part_of GO:0042698 ! ovulation cycle + +[Term] +id: GO:0022603 +name: regulation of anatomical structure morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of morphogenesis" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0022604 +name: regulation of cell morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process by which the size or shape of a cell is generated and organized." [GOC:isa_complete] +subset: gosubset_prok +synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0022605 +name: oogenesis stage +namespace: biological_process +def: "A process that contributes to the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu] +synonym: "oogenesis process" EXACT [] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0022606 +name: establishment of proximal/distal cell polarity +namespace: biological_process +def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete] +is_a: GO:0030010 ! establishment of cell polarity + +[Term] +id: GO:0022607 +name: cellular component assembly +namespace: biological_process +def: "A cellular process that results in the assembly of a part of the cell." [GOC:isa_complete] +subset: goslim_pir +subset: gosubset_prok +synonym: "cell structure assembly" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0022608 +name: multicellular organism adhesion +namespace: biological_process +def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete] +is_a: GO:0022610 ! biological adhesion +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0022609 +name: multicellular organism adhesion to substrate +namespace: biological_process +def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete] +is_a: GO:0022608 ! multicellular organism adhesion + +[Term] +id: GO:0022610 +name: biological adhesion +namespace: biological_process +def: "The attachment of a cell or organism to a substrate or other organism." [GOC:isa_complete] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0022611 +name: dormancy process +namespace: biological_process +def: "The process by which a dormant state is induced, maintained and broken. Dormancy is characterized by a suspension of physiological activity." [GOC:isa_complete] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0022612 +name: gland morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:isa_complete] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048732 ! gland development + +[Term] +id: GO:0022613 +name: ribonucleoprotein complex biogenesis and assembly +namespace: biological_process +def: "The cellular process by which a complex containing RNA and proteins, is synthesized, aggregates, and bonds together." [GOC:isa_complete] +subset: gosubset_prok +synonym: "RNA-protein complex biogenesis and assembly" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0022614 +name: membrane to membrane docking +namespace: biological_process +def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete] +synonym: "membrane-membrane docking" EXACT [] +is_a: GO:0022406 ! membrane docking + +[Term] +id: GO:0022615 +name: protein to membrane docking +namespace: biological_process +def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] +synonym: "protein-membrane docking" EXACT [] +is_a: GO:0022406 ! membrane docking + +[Term] +id: GO:0022616 +name: DNA strand elongation +namespace: biological_process +def: "The DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:isa_complete] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0022617 +name: extracellular matrix disassembly +namespace: biological_process +def: "A process that results in the breakdown of the extracellular matrix." [GOC:jic] +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0022618 +name: ribonucleoprotein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] +subset: gosubset_prok +synonym: "protein-RNA complex assembly" EXACT [] +synonym: "RNA-protein complex assembly" EXACT [] +synonym: "RNP complex assembly" EXACT [] +is_a: GO:0034622 ! cellular macromolecular complex assembly +relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis and assembly + +[Term] +id: GO:0022619 +name: generative cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0055046 ! microgametogenesis + +[Term] +id: GO:0022620 +name: vegetative cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete] +synonym: "tube cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0055046 ! microgametogenesis + +[Term] +id: GO:0022621 +name: shoot system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:isa_complete] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0022622 +name: root system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0022623 +name: proteasome-activating nucleotidase complex +namespace: cellular_component +def: "A multisubunit complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:mtg_sensu, GOC:proteasome] +synonym: "PAN" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0022624 ! proteasome accessory complex + +[Term] +id: GO:0022624 +name: proteasome accessory complex +namespace: cellular_component +def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0000502 ! proteasome complex + +[Term] +id: GO:0022625 +name: cytosolic large ribosomal subunit +namespace: cellular_component +alt_id: GO:0005842 +alt_id: GO:0009282 +alt_id: GO:0030498 +alt_id: GO:0030872 +def: "The large subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:mtg_sensu] +synonym: "50S ribosomal subunit" NARROW [] +synonym: "60S ribosomal subunit" NARROW [] +synonym: "cytosolic large ribosomal subunit (sensu Archaea)" NARROW [] +synonym: "cytosolic large ribosomal subunit (sensu Bacteria)" NARROW [] +synonym: "cytosolic large ribosomal subunit (sensu Eukaryota)" NARROW [] +synonym: "eukaryotic ribosomal LSU" NARROW [] +synonym: "prokaryotic large ribosomal subunit" NARROW [] +is_a: GO:0015934 ! large ribosomal subunit +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0022626 ! cytosolic ribosome + +[Term] +id: GO:0022626 +name: cytosolic ribosome +namespace: cellular_component +alt_id: GO:0005830 +alt_id: GO:0009281 +alt_id: GO:0030871 +def: "A ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:mtg_sensu] +synonym: "70S ribosome" NARROW [] +synonym: "80S ribosome" NARROW [] +synonym: "cytosolic ribosome (sensu Archaea)" NARROW [] +synonym: "cytosolic ribosome (sensu Bacteria)" NARROW [] +synonym: "cytosolic ribosome (sensu Eukaryota)" NARROW [] +is_a: GO:0005840 ! ribosome +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0022627 +name: cytosolic small ribosomal subunit +namespace: cellular_component +alt_id: GO:0005843 +alt_id: GO:0009283 +alt_id: GO:0030499 +alt_id: GO:0030873 +def: "The small subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:mtg_sensu] +synonym: "30S ribosomal subunit" NARROW [] +synonym: "40S ribosomal subunit" NARROW [] +synonym: "cytosolic small ribosomal subunit (sensu Archaea)" NARROW [] +synonym: "cytosolic small ribosomal subunit (sensu Bacteria)" NARROW [] +synonym: "cytosolic small ribosomal subunit (sensu Eukaryota)" NARROW [] +synonym: "eukaryotic ribosomal SSU" NARROW [] +synonym: "prokaryotic small ribosomal subunit" NARROW [] +is_a: GO:0015935 ! small ribosomal subunit +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0022626 ! cytosolic ribosome + +[Term] +id: GO:0022628 +name: chloroplast large ribosomal subunit +namespace: cellular_component +def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] +synonym: "chloroplast ribosomal large subunit complex" EXACT [] +synonym: "chloroplast ribosomal LSU complex" EXACT [] +is_a: GO:0000311 ! plastid large ribosomal subunit +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0043253 ! chloroplast ribosome + +[Term] +id: GO:0022629 +name: chloroplast small ribosomal subunit +namespace: cellular_component +def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] +synonym: "chloroplast ribosomal small subunit complex" EXACT [] +synonym: "chloroplast ribosomal SSU complex" EXACT [] +is_a: GO:0000312 ! plastid small ribosomal subunit +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0043253 ! chloroplast ribosome + +[Term] +id: GO:0022803 +name: passive transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022804 +name: active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "active carrier activity" EXACT [] +synonym: "carrier activity" EXACT [] +synonym: "permease activity" EXACT [] +synonym: "pump activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022809 +name: mobile ion carrier activity +namespace: molecular_function +def: "This is a type of carrier produced by bacteria. It enable passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ionophore" BROAD [] +is_a: GO:0022803 ! passive transmembrane transporter activity + +[Term] +id: GO:0022810 +name: membrane potential driven uniporter activity +namespace: molecular_function +def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +synonym: "porter" BROAD [] +is_a: GO:0022814 ! facilitated diffusion + +[Term] +id: GO:0022814 +name: facilitated diffusion +namespace: molecular_function +def: "Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +synonym: "porters" BROAD [] +synonym: "uniporter activity z" EXACT [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0022815 +name: large uncharged polar molecule transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0022818 +name: sodium ion uniporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0022810 ! membrane potential driven uniporter activity + +[Term] +id: GO:0022819 +name: potassium ion uniporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0022810 ! membrane potential driven uniporter activity + +[Term] +id: GO:0022820 +name: potassium ion symporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015293 ! symporter activity + +[Term] +id: GO:0022821 +name: potassium ion antiporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0022824 +name: transmitter-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015276 ! ligand-gated ion channel activity +is_a: GO:0022835 ! transmitter-gated channel activity + +[Term] +id: GO:0022825 +name: copper-exporting ATPase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined. +is_obsolete: true +replaced_by: GO:0043682 + +[Term] +id: GO:0022828 +name: phosphorylation-gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022829 +name: wide pore channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "gap junction activity" NARROW [] +synonym: "non-gated, wide pore channel activity" EXACT [] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022831 +name: narrow pore, gated channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ion channels" EXACT [] +is_a: GO:0022842 ! narrow pore channel activity + +[Term] +id: GO:0022832 +name: voltage-gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022833 +name: mechanically gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022834 +name: ligand-gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022835 +name: transmitter-gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "extracellular substance gated channel activity" EXACT [] +synonym: "neurotransmitter-gated channel activity" EXACT [] +is_a: GO:0022834 ! ligand-gated channel activity + +[Term] +id: GO:0022836 +name: gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022838 +name: substrate specific channel activity +namespace: molecular_function +def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022839 +name: ion gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022840 +name: leak channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022842 ! narrow pore channel activity + +[Term] +id: GO:0022841 +name: potassium ion leak channel activity +namespace: molecular_function +def: "Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0022840 ! leak channel activity + +[Term] +id: GO:0022842 +name: narrow pore channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022843 +name: voltage-gated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005244 ! voltage-gated ion channel activity + +[Term] +id: GO:0022848 +name: acetylcholine-gated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022824 ! transmitter-gated ion channel activity + +[Term] +id: GO:0022849 +name: glutamate-gated calcium ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022824 ! transmitter-gated ion channel activity + +[Term] +id: GO:0022850 +name: serotonin-gated cation channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022824 ! transmitter-gated ion channel activity + +[Term] +id: GO:0022851 +name: GABA-gated chloride ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022824 ! transmitter-gated ion channel activity + +[Term] +id: GO:0022852 +name: glycine-gated chloride ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022824 ! transmitter-gated ion channel activity + +[Term] +id: GO:0022853 +name: active ion transmembrane transporter +namespace: molecular_function +def: "Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:def, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0022854 +name: active large uncharged polar molecule transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022804 ! active transmembrane transporter activity +is_a: GO:0022815 ! large uncharged polar molecule transmembrane transporter activity + +[Term] +id: GO:0022855 +name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "glucose PTS transporter activity" EXACT [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022856 +name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "sorbitol PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015576 ! sorbitol transmembrane transporter activity + +[Term] +id: GO:0022857 +name: transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005386 +alt_id: GO:0015646 +def: "Catalysis of the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0022858 +name: alanine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0022859 +name: dephosphorylation-gated channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022865 +name: transmembrane electron transfer carrier +namespace: molecular_function +def: "Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5] +xref: TC:5 +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022866 +name: transmembrane 1-electron transfer carrier +namespace: molecular_function +def: "Enables transfer of 1 electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B] +is_a: GO:0022865 ! transmembrane electron transfer carrier + +[Term] +id: GO:0022867 +name: transmembrane 2-electron transfer carrier +namespace: molecular_function +def: "Enables transfer of 2 electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A] +is_a: GO:0022865 ! transmembrane electron transfer carrier + +[Term] +id: GO:0022869 +name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "lactose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015155 ! lactose transmembrane transporter activity + +[Term] +id: GO:0022870 +name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "mannose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015578 ! mannose transmembrane transporter activity + +[Term] +id: GO:0022871 +name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "sorbose PTS transporter activity" EXACT [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019194 ! sorbose transmembrane transporter activity + +[Term] +id: GO:0022872 +name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "mannitol PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015575 ! mannitol transmembrane transporter activity + +[Term] +id: GO:0022873 +name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "maltose PTS transporter activity" EXACT [] +is_a: GO:0005363 ! maltose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022874 +name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "cellobiose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019191 ! cellobiose transmembrane transporter activity + +[Term] +id: GO:0022875 +name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "galactitol PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015577 ! galactitol transmembrane transporter activity + +[Term] +id: GO:0022876 +name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "galactosamine PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019196 ! galactosamine transmembrane transporter activity + +[Term] +id: GO:0022877 +name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "fructose PTS transporter activity" EXACT [] +is_a: GO:0005353 ! fructose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022878 +name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "sucrose PTS transporter activity" EXACT [] +is_a: GO:0008515 ! sucrose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019194 ! sorbose transmembrane transporter activity + +[Term] +id: GO:0022879 +name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "trehalose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015574 ! trehalose transmembrane transporter activity +is_a: GO:0015578 ! mannose transmembrane transporter activity + +[Term] +id: GO:0022880 +name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "N-acetylglucosamine PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity +is_a: GO:0015574 ! trehalose transmembrane transporter activity + +[Term] +id: GO:0022881 +name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "N-acetylgalactosamine PTS transporter activity" EXACT [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity + +[Term] +id: GO:0022882 +name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "beta-glucoside PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity + +[Term] +id: GO:0022883 +name: zinc efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "zinc efflux permease activity" EXACT [] +is_a: GO:0046583 ! cation efflux transmembrane transporter activity + +[Term] +id: GO:0022884 +name: macromolecule transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a macromolecule from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0022885 +name: bacteriocin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a bacteriocin from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity + +[Term] +id: GO:0022886 +name: channel-forming ionophore activity +namespace: molecular_function +def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ionophore activity" BROAD [] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022889 +name: serine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0022890 +name: inorganic cation transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0008324 ! cation transmembrane transporter activity + +[Term] +id: GO:0022891 +name: substrate-specific transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jic, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0022857 ! transmembrane transporter activity +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0022892 +name: substrate-specific transporter activity +namespace: molecular_function +def: "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:mtg_transport] +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0022893 +name: low-affinity tryptophan transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015510 +def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] +synonym: "low-affinity tryptophan permease activity" RELATED [] +is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity + +[Term] +id: GO:0022894 +name: Intermediate conductance calcium-activated potassium channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] +synonym: "IK calcium-activated potassium channel activity " EXACT [] +synonym: "IK KCa channels" EXACT [] +synonym: "intermdiate conductance KCa channels " EXACT [] +is_a: GO:0015269 ! calcium-activated potassium channel activity + +[Term] +id: GO:0022897 +name: proton-dependent peptide secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport] +subset: gosubset_prok +synonym: "hydrogen/oligopeptide symporter" RELATED [] +is_a: GO:0015197 ! peptide transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0022898 +name: regulation of transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] +subset: gosubset_prok +is_a: GO:0032409 ! regulation of transporter activity + +[Term] +id: GO:0022900 +name: electron transport chain +namespace: biological_process +def: "A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] +subset: gosubset_prok +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:0055114 ! oxidation reduction + +[Term] +id: GO:0022904 +name: respiratory electron transport chain +namespace: biological_process +def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "6-phosphofructokinase reduction" RELATED [] +synonym: "dihydrobiopterin reduction" RELATED [] +synonym: "dihydrolipoamide reduction" RELATED [] +synonym: "dihydrolipoylprotein reduction" RELATED [] +synonym: "dihydropteridine reduction" RELATED [] +synonym: "electron transfer" EXACT [] +synonym: "other pathways of electron transport" RELATED [] +synonym: "oxidized glutathione reduction" RELATED [] +synonym: "protein-disulfide reduction" RELATED [] +is_a: GO:0022900 ! electron transport chain + +[Term] +id: GO:0023002 +name: nuclear migration to embryo sac poles +namespace: biological_process +def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jic, GOC:mtg_plant, ISBN:047186840X] +synonym: "nuclear migration to female gametophyte poles" EXACT [] +synonym: "nuclear migration to megagametophyte poles" EXACT [] +synonym: "nucleus migration to embryo sac poles" EXACT [] +synonym: "nucleus migration to female gametophyte poles" EXACT [] +synonym: "nucleus migration to megagametophyte poles" EXACT [] +is_a: GO:0009562 ! embryo sac nuclear migration + +[Term] +id: GO:0023003 +name: nuclear migration to the embryo sac center +namespace: biological_process +def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jic, GOC:mtg_plant, ISBN:047186840X] +synonym: "nuclear migration to the embryo sac centre" EXACT [] +synonym: "nuclear migration to the female gametophyte center" EXACT [] +synonym: "nuclear migration to the female gametophyte centre" EXACT [] +synonym: "nuclear migration to the megagametophyte center" EXACT [] +synonym: "nuclear migration to the megagametophyte centre" EXACT [] +synonym: "nucleus migration to the female gametophyte center" EXACT [] +synonym: "nucleus migration to the female gametophyte centre" EXACT [] +is_a: GO:0009562 ! embryo sac nuclear migration + +[Term] +id: GO:0030001 +name: metal ion transport +namespace: biological_process +def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "heavy metal ion transport" NARROW [] +is_a: GO:0006812 ! cation transport + +[Term] +id: GO:0030002 +name: cellular anion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of anions within a cell or between a cell and its external environment." [GOC:ceb] +is_a: GO:0006873 ! cellular ion homeostasis +is_a: GO:0055081 ! anion homeostasis + +[Term] +id: GO:0030003 +name: cellular cation homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of cations within a cell or between a cell and its external environment." [GOC:ceb] +subset: gosubset_prok +is_a: GO:0006873 ! cellular ion homeostasis +is_a: GO:0055080 ! cation homeostasis + +[Term] +id: GO:0030004 +name: cellular monovalent inorganic cation homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of monovalent inorganic cations within a cell or between a cell and its external environment." [GOC:ai] +subset: gosubset_prok +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0030005 +name: cellular di-, tri-valent inorganic cation homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic cations within a cell or between a cell and its external environment." [GOC:ceb] +subset: gosubset_prok +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0030006 +name: heavy cellular metal ion homeostasis +namespace: biological_process +def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +is_obsolete: true +consider: GO:0006875 + +[Term] +id: GO:0030007 +name: cellular potassium ion homeostasis +namespace: biological_process +alt_id: GO:0017079 +def: "The regulation of the levels, transport, and metabolism of potassium ions within a cell or between a cell and its external environment." [GOC:mah] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0055075 ! potassium ion homeostasis + +[Term] +id: GO:0030008 +name: TRAPP complex +namespace: cellular_component +def: "A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion." [PMID:9564032] +synonym: "transport protein particle" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0005801 ! cis-Golgi network + +[Term] +id: GO:0030009 +name: complement factor H activity +namespace: molecular_function +def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0006956 + +[Term] +id: GO:0030010 +name: establishment of cell polarity +namespace: biological_process +alt_id: GO:0000283 +alt_id: GO:0030468 +def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" NARROW [] +synonym: "cell polarization" EXACT [] +synonym: "establishment of cell polarity (sensu Fungi)" NARROW [] +synonym: "establishment of cell polarity (sensu Saccharomyces)" NARROW [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0030011 +name: maintenance of cell polarity +namespace: biological_process +alt_id: GO:0030013 +alt_id: GO:0030469 +def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] +synonym: "maintenance of cell polarity (sensu Fungi)" NARROW [] +synonym: "maintenance of cell polarity (sensu Saccharomyces)" NARROW [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0030014 +name: CCR4-NOT complex +namespace: cellular_component +def: "A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins." [PMID:11113136] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0030015 +name: CCR4-NOT core complex +namespace: cellular_component +def: "The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p." [PMID:11113136] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part +relationship: part_of GO:0030014 ! CCR4-NOT complex + +[Term] +id: GO:0030016 +name: myofibril +namespace: cellular_component +def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] +synonym: "striated muscle fiber" EXACT [] +synonym: "striated muscle fibre" EXACT [] +is_a: GO:0043292 ! contractile fiber + +[Term] +id: GO:0030017 +name: sarcomere +namespace: cellular_component +def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0030016 ! myofibril + +[Term] +id: GO:0030018 +name: Z disc +namespace: cellular_component +def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] +synonym: "Z band" EXACT [] +synonym: "Z disk" EXACT [] +synonym: "Z line" EXACT [] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0031674 ! I band + +[Term] +id: GO:0030019 +name: tryptase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "lung tryptase activity" NARROW [EC:3.4.21.59] +synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59] +synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59] +synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59] +synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59] +synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59] +synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59] +synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59] +synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59] +synonym: "skin tryptase activity" NARROW [EC:3.4.21.59] +synonym: "tryptase M" RELATED [EC:3.4.21.59] +xref: EC:3.4.21.59 +xref: MetaCyc:3.4.21.59-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030020 +name: extracellular matrix structural constituent conferring tensile strength +namespace: molecular_function +def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030021 +name: extracellular matrix structural constituent conferring compression resistance +namespace: molecular_function +def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030022 +name: adhesive extracellular matrix constituent +namespace: molecular_function +def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +replaced_by: GO:0005578 +replaced_by: GO:0030674 +replaced_by: GO:0050839 +replaced_by: GO:0050840 + +[Term] +id: GO:0030023 +name: extracellular matrix constituent conferring elasticity +namespace: molecular_function +def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] +synonym: "elastin" RELATED [] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030026 +name: cellular manganese ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of manganese ions within a cell or between a cell and its external environment." [GOC:mah] +subset: gosubset_prok +synonym: "manganese homeostasis" BROAD [] +is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis +is_a: GO:0055071 ! manganese ion homeostasis + +[Term] +id: GO:0030027 +name: lamellipodium +namespace: cellular_component +def: "A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [ISBN:0815316194] +is_a: GO:0042995 ! cell projection +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0030029 +name: actin filament-based process +namespace: biological_process +def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] +synonym: "microfilament-based process" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0030030 +name: cell projection organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] +subset: gosubset_prok +synonym: "cell projection organisation and biogenesis" EXACT [] +synonym: "cell projection organization and biogenesis" EXACT [] +synonym: "cell surface structure organization and biogenesis" BROAD [] +is_a: GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0030031 +name: cell projection biogenesis +namespace: biological_process +def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] +subset: gosubset_prok +synonym: "formation of a cell surface projection" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0030032 +name: lamellipodium biogenesis +namespace: biological_process +def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] +synonym: "lamellipodium biosynthesis" EXACT [] +synonym: "lamellipodium formation" EXACT [] +is_a: GO:0030031 ! cell projection biogenesis + +[Term] +id: GO:0030033 +name: microvillus biogenesis +namespace: biological_process +def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] +is_a: GO:0030031 ! cell projection biogenesis +is_a: GO:0032528 ! microvillus organization + +[Term] +id: GO:0030034 +name: microvillar actin bundle formation +namespace: biological_process +def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah] +is_a: GO:0051017 ! actin filament bundle formation +relationship: part_of GO:0030033 ! microvillus biogenesis + +[Term] +id: GO:0030035 +name: microspike biogenesis +namespace: biological_process +def: "Formation of a microspike, a thin, stiff projection extended from the surface of a migrating cell." [GOC:mah, ISBN:0815316194] +synonym: "microspike biosynthesis" EXACT [] +synonym: "microspike formation" EXACT [] +is_a: GO:0030031 ! cell projection biogenesis + +[Term] +id: GO:0030036 +name: actin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] +synonym: "actin cytoskeleton organisation and biogenesis" EXACT [] +synonym: "actin cytoskeleton organization and biogenesis" EXACT [] +synonym: "actin modulating activity" RELATED [] +is_a: GO:0030029 ! actin filament-based process + +[Term] +id: GO:0030037 +name: actin filament reorganization during cell cycle +namespace: biological_process +def: "The cell cycle process whereby rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah] +synonym: "actin filament reorganization during cell cycle" EXACT [] +is_a: GO:0007015 ! actin filament organization +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031532 ! actin cytoskeleton reorganization + +[Term] +id: GO:0030038 +name: contractile actin filament bundle formation +namespace: biological_process +def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194] +is_a: GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0030039 +name: DNA unwinding factor +namespace: molecular_function +alt_id: GO:0017152 +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +is_obsolete: true +replaced_by: GO:0006268 + +[Term] +id: GO:0030041 +name: actin filament polymerization +namespace: biological_process +def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] +synonym: "actin polymerization" EXACT [] +synonym: "actin polymerizing activity" RELATED [] +is_a: GO:0008154 ! actin polymerization or depolymerization +is_a: GO:0051258 ! protein polymerization + +[Term] +id: GO:0030042 +name: actin filament depolymerization +namespace: biological_process +def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] +synonym: "actin depolymerization" EXACT [] +synonym: "actin depolymerizing activity" RELATED [] +is_a: GO:0008154 ! actin polymerization or depolymerization +is_a: GO:0051261 ! protein depolymerization + +[Term] +id: GO:0030043 +name: actin filament fragmentation +namespace: biological_process +def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] +is_a: GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030046 +name: parallel actin filament bundle formation +namespace: biological_process +def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194] +is_a: GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0030047 +name: actin modification +namespace: biological_process +alt_id: GO:0007013 +def: "Covalent modification of an actin molecule." [GOC:mah] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0030048 +name: actin filament-based movement +namespace: biological_process +def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:mah] +is_a: GO:0030029 ! actin filament-based process +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport + +[Term] +id: GO:0030049 +name: muscle filament sliding +namespace: biological_process +def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194] +is_a: GO:0033275 ! actin-myosin filament sliding +relationship: part_of GO:0006936 ! muscle contraction + +[Term] +id: GO:0030050 +name: vesicle transport along actin filament +namespace: biological_process +def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] +is_a: GO:0030048 ! actin filament-based movement + +[Term] +id: GO:0030051 +name: FK506-sensitive peptidyl-prolyl cis-trans isomerase +namespace: molecular_function +def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198596732] +comment: This term was made obsolete because it represents a gene product and not a function. +synonym: "FK506 binding protein" RELATED [] +synonym: "FKBP" RELATED [] +is_obsolete: true +replaced_by: GO:0003755 +replaced_by: GO:0005528 + +[Term] +id: GO:0030052 +name: parvulin +namespace: molecular_function +def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it describes a gene product. +is_obsolete: true +replaced_by: GO:0003755 + +[Term] +id: GO:0030053 +name: immunophilin +namespace: molecular_function +def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it does not represent a molecular function. +is_obsolete: true +consider: GO:0003755 +consider: GO:0004872 + +[Term] +id: GO:0030054 +name: cell junction +namespace: cellular_component +def: "A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0030055 +name: cell-substrate junction +namespace: cellular_component +def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:hb, GOC:mah] +synonym: "cell-matrix junction" EXACT [] +is_a: GO:0030054 ! cell junction +relationship: part_of GO:0016323 ! basolateral plasma membrane + +[Term] +id: GO:0030056 +name: hemidesmosome +namespace: cellular_component +def: "A cell-substrate junction that forms a point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments." [ISBN:0815316208] +synonym: "hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction] +is_a: GO:0030055 ! cell-substrate junction +relationship: part_of GO:0009925 ! basal plasma membrane + +[Term] +id: GO:0030057 +name: desmosome +namespace: cellular_component +def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] +synonym: "macula adherens" EXACT [] +synonym: "spot desmosome" EXACT [] +is_a: GO:0005911 ! cell-cell junction +is_a: GO:0070161 ! anchoring junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0030058 +name: amine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3] +subset: gosubset_prok +synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] +synonym: "MADH activity" EXACT [EC:1.4.99.3] +synonym: "methylamine dehydrogenase activity" EXACT [EC:1.4.99.3] +synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.99.3] +synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] +synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] +xref: EC:1.4.99.3 +xref: MetaCyc:AMINE-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0058 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0030059 +name: aralkylamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor; acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine." [EC:1.4.99.4] +synonym: "aralkylamine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.4] +synonym: "aralkylamine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.4] +synonym: "aromatic amine dehydrogenase activity" EXACT [EC:1.4.99.4] +synonym: "dehydrogenase, arylamine" EXACT [EC:1.4.99.4] +synonym: "tyramine dehydrogenase activity" EXACT [EC:1.4.99.4] +xref: EC:1.4.99.4 +xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0030060 +name: L-malate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids." [EC:1.1.1.37] +subset: gosubset_prok +synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] +synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] +synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "MDH" RELATED [EC:1.1.1.37] +synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "NAD-L-malate dehydrogenase activity" EXACT [] +synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37] +synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37] +xref: EC:1.1.1.37 +xref: MetaCyc:MALATE-DEH-RXN +xref: Reactome:19541 +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030061 +name: mitochondrial crista +namespace: cellular_component +def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +synonym: "mitochondrial cristae" EXACT [] +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0030062 +name: mitochondrial tricarboxylic acid cycle enzyme complex +namespace: cellular_component +def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] +synonym: "TCA cycle enzyme complex (sensu Eukaryota)" EXACT [] +synonym: "tricarboxylic acid cycle enzyme complex (sensu Eukaryota)" EXACT [] +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0030063 +name: murein sacculus +namespace: cellular_component +def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891] +comment: This term was made obsolete because it was defined inaccurately. +synonym: "peptidoglycan layer" EXACT [] +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0030064 +name: cell wall inner membrane +namespace: cellular_component +def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254] +comment: This term was made obsolete because it was defined inaccurately. +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0030066 +name: cytochrome b6 +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome b-563" RELATED [] +is_obsolete: true +replaced_by: GO:0045158 + +[Term] +id: GO:0030067 +name: respiratory chain cytochrome b6 +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0030068 +name: lytic viral life cycle +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +is_obsolete: true +consider: GO:0019058 +consider: GO:0019077 + +[Term] +id: GO:0030069 +name: lysogeny +namespace: biological_process +def: "The incorporation of a bacteriophage genome into the genome of its bacterial host organism." [ISBN:0781702534] +is_a: GO:0022415 ! viral reproductive process + +[Term] +id: GO:0030070 +name: insulin processing +namespace: biological_process +def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0016486 ! peptide hormone processing +is_a: GO:0051605 ! protein maturation via proteolysis + +[Term] +id: GO:0030071 +name: regulation of mitotic metaphase/anaphase transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah] +is_a: GO:0007088 ! regulation of mitosis +relationship: regulates GO:0007091 ! mitotic metaphase/anaphase transition + +[Term] +id: GO:0030072 +name: peptide hormone secretion +namespace: biological_process +def: "The regulated release of a peptide hormone from secretory granules." [GOC:mah] +is_a: GO:0002790 ! peptide secretion +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0030073 +name: insulin secretion +namespace: biological_process +def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0030074 +name: thylakoid (sensu Proteobacteria) +namespace: cellular_component +def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah] +comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria. +is_obsolete: true +consider: GO:0042716 + +[Term] +id: GO:0030075 +name: plasma membrane-derived thylakoid +namespace: cellular_component +def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "thylakoid (sensu Cyanobacteria)" EXACT [] +is_a: GO:0009579 ! thylakoid +is_a: GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0030076 +name: light-harvesting complex +namespace: cellular_component +def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr] +subset: goslim_pir +subset: gosubset_prok +synonym: "antenna complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0030077 +name: plasma membrane light-harvesting complex +namespace: cellular_component +def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "light-harvesting complex (sensu Gram-negative Bacteria)" EXACT [] +synonym: "light-harvesting complex (sensu Proteobacteria)" EXACT [] +is_a: GO:0030076 ! light-harvesting complex +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0030078 +name: light-harvesting complex, core complex +namespace: cellular_component +def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr] +subset: gosubset_prok +is_a: GO:0030077 ! plasma membrane light-harvesting complex + +[Term] +id: GO:0030079 +name: light-harvesting complex, peripheral complex +namespace: cellular_component +def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr] +subset: gosubset_prok +is_a: GO:0030077 ! plasma membrane light-harvesting complex + +[Term] +id: GO:0030080 +name: B875 antenna complex +namespace: cellular_component +def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd] +subset: gosubset_prok +synonym: "LH1 complex" EXACT [] +synonym: "light harvesting complex I" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030078 ! light-harvesting complex, core complex + +[Term] +id: GO:0030081 +name: B800-820 antenna complex +namespace: cellular_component +def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] +subset: gosubset_prok +synonym: "LH3 complex" EXACT [] +synonym: "light harvesting complex III" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex + +[Term] +id: GO:0030082 +name: B800-850 antenna complex +namespace: cellular_component +def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] +subset: gosubset_prok +synonym: "LH2 complex" EXACT [] +synonym: "light harvesting complex II" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex + +[Term] +id: GO:0030083 +name: PSI associated light-harvesting complex I, LHCIa subcomplex +namespace: cellular_component +def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475] +is_a: GO:0009518 ! PSI associated light-harvesting complex I + +[Term] +id: GO:0030084 +name: PSI associated light-harvesting complex I, LHCIb subcomplex +namespace: cellular_component +def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475] +is_a: GO:0009518 ! PSI associated light-harvesting complex I + +[Term] +id: GO:0030085 +name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex +namespace: cellular_component +def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex + +[Term] +id: GO:0030086 +name: PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. +is_obsolete: true +replaced_by: GO:0009655 + +[Term] +id: GO:0030087 +name: PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. +is_obsolete: true +replaced_by: GO:0009655 + +[Term] +id: GO:0030088 +name: PSII associated light-harvesting complex II, core complex, LHCIId subcomplex +namespace: cellular_component +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. +is_obsolete: true +replaced_by: GO:0009655 + +[Term] +id: GO:0030089 +name: phycobilisome +namespace: cellular_component +def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0030076 ! light-harvesting complex +is_a: GO:0044433 ! cytoplasmic vesicle part +is_a: GO:0044435 ! plastid part +is_a: GO:0044436 ! thylakoid part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0009843 ! cyanelle thylakoid +relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid + +[Term] +id: GO:0030091 +name: protein repair +namespace: biological_process +def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0030092 +name: regulation of flagellum biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] +synonym: "regulation of flagella biogenesis" EXACT [] +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0009296 ! flagellum biogenesis + +[Term] +id: GO:0030093 +name: chloroplast photosystem I +namespace: cellular_component +def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin." [GOC:jic, GOC:mtg_sensu] +synonym: "photosystem I (sensu Magnoliophyta)" EXACT [] +is_a: GO:0009522 ! photosystem I +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009535 ! chloroplast thylakoid membrane + +[Term] +id: GO:0030094 +name: plasma membrane-derived photosystem I +namespace: cellular_component +def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin." [GOC:jic, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "photosystem I (sensu Cyanobacteria)" EXACT [] +synonym: "plasma membrane photosystem I" EXACT [] +is_a: GO:0009522 ! photosystem I +is_a: GO:0044436 ! thylakoid part +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid + +[Term] +id: GO:0030095 +name: chloroplast photosystem II +namespace: cellular_component +def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jic, GOC:mtg_sensu] +synonym: "photosystem II (sensu Viridiplantae)" EXACT [] +is_a: GO:0009523 ! photosystem II +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0009535 ! chloroplast thylakoid membrane + +[Term] +id: GO:0030096 +name: plasma membrane-derived thylakoid photosystem II +namespace: cellular_component +def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jic, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "photosystem II (sensu Cyanobacteria)" EXACT [] +synonym: "plasma membrane photosystem II" EXACT [] +is_a: GO:0009523 ! photosystem II +is_a: GO:0044436 ! thylakoid part +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid + +[Term] +id: GO:0030097 +name: hemopoiesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "blood cell biosynthesis" EXACT [] +synonym: "blood cell formation" EXACT [] +synonym: "haemopoiesis" EXACT [] +synonym: "hematopoiesis" EXACT [] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development + +[Term] +id: GO:0030098 +name: lymphocyte differentiation +namespace: biological_process +alt_id: GO:0046650 +def: "The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells." [GOC:go_curators] +synonym: "lymphocyte cell differentiation" EXACT [] +synonym: "lymphocytic blood cell differentiation" EXACT [] +is_a: GO:0002521 ! leukocyte differentiation +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0030099 +name: myeloid cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0030100 +name: regulation of endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] +is_a: GO:0051049 ! regulation of transport +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006897 ! endocytosis + +[Term] +id: GO:0030101 +name: natural killer cell activation +namespace: biological_process +def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140] +synonym: "NK cell activation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0030103 +name: vasopressin secretion +namespace: biological_process +def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0030104 +name: water homeostasis +namespace: biological_process +alt_id: GO:0018987 +def: "Any process involved in the maintenance of an internal equilibrium of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] +synonym: "osmoregulation" RELATED [] +synonym: "regulation of osmotic pressure" EXACT [] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0030105 +name: anaphylaxis +namespace: biological_process +def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism. +is_obsolete: true +consider: GO:0006955 + +[Term] +id: GO:0030106 +name: MHC class I receptor activity +namespace: molecular_function +def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971] +comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'. +synonym: "class I major histocompatibility complex antigen" RELATED [] +synonym: "major histocompatibility complex class I receptor" EXACT [] +is_obsolete: true +consider: GO:0032393 +consider: GO:0042612 + +[Term] +id: GO:0030107 +name: HLA-A specific inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032396 ! inhibitory MHC class I receptor activity + +[Term] +id: GO:0030108 +name: HLA-A specific activating MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032397 ! activating MHC class I receptor activity + +[Term] +id: GO:0030109 +name: HLA-B specific inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032396 ! inhibitory MHC class I receptor activity + +[Term] +id: GO:0030110 +name: HLA-C specific inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032396 ! inhibitory MHC class I receptor activity + +[Term] +id: GO:0030111 +name: regulation of Wnt receptor signaling pathway +namespace: biological_process +alt_id: GO:0008590 +def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of frizzled signaling pathway" EXACT [] +synonym: "regulation of frizzled signalling pathway" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0016055 ! Wnt receptor signaling pathway + +[Term] +id: GO:0030112 +name: glycocalyx +namespace: cellular_component +def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0030114 +name: slime layer +namespace: cellular_component +def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, http://www.wikipedia.org/] +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0030115 +name: S-layer +namespace: cellular_component +def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0030116 +name: glial cell line-derived neurotrophic factor receptor binding +namespace: molecular_function +def: "A growth factor that binds to glial cell line-derived neurotrophic factor receptors." [PMID:11476867] +synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW [] +is_a: GO:0008083 ! growth factor activity + +[Term] +id: GO:0030117 +name: membrane coat +namespace: cellular_component +def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0048475 ! coated membrane + +[Term] +id: GO:0030118 +name: clathrin coat +namespace: cellular_component +alt_id: GO:0016190 +def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] +synonym: "clathrin cage" EXACT [] +is_a: GO:0030117 ! membrane coat + +[Term] +id: GO:0030119 +name: AP-type membrane coat adaptor complex +namespace: cellular_component +def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] +subset: goslim_pir +synonym: "clathrin adaptor" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0030117 ! membrane coat + +[Term] +id: GO:0030120 +name: vesicle coat +namespace: cellular_component +def: "A membrane coat found on a coated vesicle." [GOC:mah] +is_a: GO:0030117 ! membrane coat +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030662 ! coated vesicle membrane + +[Term] +id: GO:0030121 +name: AP-1 adaptor complex +namespace: cellular_component +def: "An AP-type membrane coat adaptor complex that consists of beta1, gamma1, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network." [GOC:mah, PMID:10611976] +synonym: "HA1" EXACT [] +synonym: "HA1 clathrin adaptor" EXACT [] +is_a: GO:0030131 ! clathrin adaptor complex +is_a: GO:0044431 ! Golgi apparatus part +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle + +[Term] +id: GO:0030122 +name: AP-2 adaptor complex +namespace: cellular_component +def: "An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles." [GOC:mah, PMID:10611976] +synonym: "HA2" EXACT [] +synonym: "HA2 clathrin adaptor" EXACT [] +is_a: GO:0030131 ! clathrin adaptor complex +is_a: GO:0044433 ! cytoplasmic vesicle part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle +relationship: part_of GO:0030132 ! clathrin coat of coated pit + +[Term] +id: GO:0030123 +name: AP-3 adaptor complex +namespace: cellular_component +def: "An AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes; it is not clear whether AP-3 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex + +[Term] +id: GO:0030124 +name: AP-4 adaptor complex +namespace: cellular_component +def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex + +[Term] +id: GO:0030125 +name: clathrin vesicle coat +namespace: cellular_component +def: "A clathrin coat found on a vesicle." [GOC:mah] +is_a: GO:0030118 ! clathrin coat +is_a: GO:0030120 ! vesicle coat +relationship: part_of GO:0030665 ! clathrin coated vesicle membrane + +[Term] +id: GO:0030126 +name: COPI vesicle coat +namespace: cellular_component +alt_id: GO:0017167 +def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] +synonym: "coatomer" EXACT [] +is_a: GO:0030120 ! vesicle coat +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0030663 ! COPI coated vesicle membrane + +[Term] +id: GO:0030127 +name: COPII vesicle coat +namespace: cellular_component +def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:mah, PMID:11252894] +is_a: GO:0030120 ! vesicle coat +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane + +[Term] +id: GO:0030128 +name: clathrin coat of endocytic vesicle +namespace: cellular_component +def: "A clathrin coat found on an endocytic vesicle." [GOC:mah] +synonym: "clathrin coat of endocytotic vesicle" EXACT [] +is_a: GO:0030125 ! clathrin vesicle coat +relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane + +[Term] +id: GO:0030129 +name: clathrin coat of synaptic vesicle +namespace: cellular_component +def: "A clathrin coat found on a synaptic vesicle." [GOC:mah] +is_a: GO:0030125 ! clathrin vesicle coat +relationship: part_of GO:0030672 ! synaptic vesicle membrane + +[Term] +id: GO:0030130 +name: clathrin coat of trans-Golgi network vesicle +namespace: cellular_component +def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] +synonym: "clathrin coat of TGN vesicle" EXACT [] +is_a: GO:0030125 ! clathrin vesicle coat +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane + +[Term] +id: GO:0030131 +name: clathrin adaptor complex +namespace: cellular_component +def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex +relationship: part_of GO:0030118 ! clathrin coat + +[Term] +id: GO:0030132 +name: clathrin coat of coated pit +namespace: cellular_component +def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] +is_a: GO:0030118 ! clathrin coat +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005905 ! coated pit + +[Term] +id: GO:0030133 +name: transport vesicle +namespace: cellular_component +def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, and to destinations within or outside the cell." [GOC:mah] +comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. +synonym: "Golgi to plasma membrane transport vesicle" NARROW [] +synonym: "Golgi to vacuole transport vesicle" NARROW [] +synonym: "Golgi-plasma membrane transport vesicle" NARROW [] +synonym: "Golgi-vacuole transport vesicle" NARROW [] +synonym: "secretory vesicle" BROAD [] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0030134 +name: ER to Golgi transport vesicle +namespace: cellular_component +alt_id: GO:0030138 +def: "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:mah, PMID:11252894] +synonym: "COPII vesicle" RELATED [] +synonym: "COPII-coated vesicle" EXACT [] +synonym: "endoplasmic reticulum to Golgi transport vesicle" EXACT [] +synonym: "endoplasmic reticulum-Golgi transport vesicle" EXACT [] +synonym: "ER-Golgi transport vesicle" EXACT [] +is_a: GO:0005798 ! Golgi-associated vesicle +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030135 ! coated vesicle + +[Term] +id: GO:0030135 +name: coated vesicle +namespace: cellular_component +alt_id: GO:0005909 +def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0030136 +name: clathrin-coated vesicle +namespace: cellular_component +def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] +is_a: GO:0030135 ! coated vesicle + +[Term] +id: GO:0030137 +name: COPI-coated vesicle +namespace: cellular_component +def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] +synonym: "coatomer" RELATED [] +is_a: GO:0005798 ! Golgi-associated vesicle +is_a: GO:0030135 ! coated vesicle + +[Term] +id: GO:0030139 +name: endocytic vesicle +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] +subset: gosubset_prok +synonym: "endocytotic transport vesicle" EXACT [] +synonym: "endocytotic vesicle" EXACT [] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0030140 +name: trans-Golgi network transport vesicle +namespace: cellular_component +def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] +synonym: "TGN transport vesicle" EXACT [] +is_a: GO:0005798 ! Golgi-associated vesicle +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0030141 +name: secretory granule +namespace: cellular_component +def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732] +comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. +synonym: "secretory vesicle" BROAD [] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0030142 +name: Golgi to ER transport vesicle +namespace: cellular_component +def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah] +synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT [] +synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT [] +synonym: "Golgi-ER transport vesicle" EXACT [] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0030143 +name: inter-Golgi transport vesicle +namespace: cellular_component +alt_id: GO:0005807 +def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0030144 +name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155] +synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] +synonym: "GnTV activity" EXACT [EC:2.4.1.155] +synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155] +synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155] +synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] +synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] +synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] +synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] +xref: EC:2.4.1.155 +xref: MetaCyc:2.4.1.155-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0030145 +name: manganese ion binding +namespace: molecular_function +def: "Interacting selectively with manganese (Mn) ions." [GOC:ai] +subset: gosubset_prok +synonym: "manganese binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0030146 +name: diuresis +namespace: biological_process +alt_id: GO:0003076 +def: "The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "positive regulation of renal water excretion" EXACT [] +synonym: "renal water excretion" BROAD [] +is_a: GO:0003014 ! renal system process +is_a: GO:0007588 ! excretion +is_a: GO:0007589 ! body fluid secretion +relationship: part_of GO:0003091 ! renal water homeostasis + +[Term] +id: GO:0030147 +name: natriuresis +namespace: biological_process +def: "The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0007588 ! excretion +is_a: GO:0050801 ! ion homeostasis + +[Term] +id: GO:0030148 +name: sphingolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingolipid anabolism" EXACT [] +synonym: "sphingolipid biosynthesis" EXACT [] +synonym: "sphingolipid formation" EXACT [] +synonym: "sphingolipid synthesis" EXACT [] +xref: MetaCyc:PWY-5129 +is_a: GO:0006665 ! sphingolipid metabolic process +is_a: GO:0046467 ! membrane lipid biosynthetic process + +[Term] +id: GO:0030149 +name: sphingolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingolipid breakdown" EXACT [] +synonym: "sphingolipid catabolism" EXACT [] +synonym: "sphingolipid degradation" EXACT [] +is_a: GO:0006665 ! sphingolipid metabolic process +is_a: GO:0046466 ! membrane lipid catabolic process + +[Term] +id: GO:0030150 +name: protein import into mitochondrial matrix +namespace: biological_process +def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] +synonym: "mitochondrial matrix protein import" EXACT [] +synonym: "mitochondrial translocation" BROAD [] +synonym: "protein transport into mitochondrial matrix" EXACT [] +is_a: GO:0043681 ! protein import into mitochondrion +is_a: GO:0065002 ! intracellular protein transmembrane transport + +[Term] +id: GO:0030151 +name: molybdenum ion binding +namespace: molecular_function +def: "Interacting selectively with molybdenum (Mo) ions." [GOC:ai] +subset: gosubset_prok +synonym: "molybdenum binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0030152 +name: bacteriocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "bacteriocin anabolism" EXACT [] +synonym: "bacteriocin biosynthesis" EXACT [] +synonym: "bacteriocin formation" EXACT [] +synonym: "bacteriocin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0046224 ! bacteriocin metabolic process + +[Term] +id: GO:0030153 +name: bacteriocin immunity +namespace: biological_process +def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0009404 ! toxin metabolic process + +[Term] +id: GO:0030154 +name: cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_goa +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0030155 +name: regulation of cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] +subset: gosubset_prok +synonym: "cell adhesion receptor regulator activity" RELATED [] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007155 ! cell adhesion + +[Term] +id: GO:0030156 +name: benzodiazepine receptor binding +namespace: molecular_function +def: "Interacting selectively with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832] +synonym: "benzodiazepine receptor ligand" NARROW [] +synonym: "diazepam binding inhibitor activity" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0030157 +name: pancreatic juice secretion +namespace: biological_process +def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0030158 +name: protein xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] +synonym: "peptide O-xylosyltransferase activity" EXACT [] +synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] +synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26] +synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] +synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] +synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] +synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26] +synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26] +xref: EC:2.4.2.26 +xref: MetaCyc:2.4.2.26-RXN +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0030159 +name: receptor signaling complex scaffold activity +namespace: molecular_function +def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] +synonym: "receptor signaling complex scaffold protein activity" EXACT [] +synonym: "receptor signalling complex scaffold activity" EXACT [] +is_a: GO:0032947 ! protein complex scaffold + +[Term] +id: GO:0030160 +name: GKAP/Homer scaffold activity +namespace: molecular_function +def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216] +synonym: "GKAP/Homer scaffold protein" NARROW [] +synonym: "postsynaptic density scaffold protein" NARROW [] +is_a: GO:0030159 ! receptor signaling complex scaffold activity + +[Term] +id: GO:0030161 +name: calpain inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai] +is_a: GO:0004869 ! cysteine protease inhibitor activity + +[Term] +id: GO:0030162 +name: regulation of proteolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of peptidolysis" EXACT [] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0006508 ! proteolysis + +[Term] +id: GO:0030163 +name: protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] +subset: goslim_candida +subset: goslim_yeast +subset: gosubset_prok +synonym: "pheromone catabolic process (sensu Saccharomyces)" NARROW [] +synonym: "pheromone catabolism (sensu Saccharomyces)" NARROW [] +synonym: "protein breakdown" EXACT [] +synonym: "protein catabolism" EXACT [] +synonym: "protein degradation" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0043285 ! biopolymer catabolic process + +[Term] +id: GO:0030164 +name: protein denaturation +namespace: biological_process +def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359] +subset: gosubset_prok +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0030165 +name: PDZ domain binding +namespace: molecular_function +def: "Interacting selectively with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] +synonym: "DHR-domain binding" EXACT [] +synonym: "GLGF-domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030166 +name: proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "proteoglycan anabolism" EXACT [] +synonym: "proteoglycan biosynthesis" EXACT [] +synonym: "proteoglycan formation" EXACT [] +synonym: "proteoglycan synthesis" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0030167 +name: proteoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "proteoglycan breakdown" EXACT [] +synonym: "proteoglycan catabolism" EXACT [] +synonym: "proteoglycan degradation" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0030168 +name: platelet activation +namespace: biological_process +def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0007596 ! blood coagulation + +[Term] +id: GO:0030169 +name: low-density lipoprotein binding +namespace: molecular_function +def: "Interacting selectively with low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "LDL binding" EXACT [] +is_a: GO:0008034 ! lipoprotein binding + +[Term] +id: GO:0030170 +name: pyridoxal phosphate binding +namespace: molecular_function +def: "Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "vitamin B6 binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0048037 ! cofactor binding + +[Term] +id: GO:0030171 +name: voltage-gated proton channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a proton by a voltage-gated channel." [ISBN:10615049] +synonym: "voltage gated proton channel activity" EXACT [] +synonym: "voltage-dependent proton channel activity" EXACT [] +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0030172 +name: troponin C binding +namespace: molecular_function +def: "Interacting selectively with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0030173 +name: integral to Golgi membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] +synonym: "Golgi integral membrane protein" RELATED [] +is_a: GO:0031228 ! intrinsic to Golgi membrane +is_a: GO:0031301 ! integral to organelle membrane + +[Term] +id: GO:0030174 +name: regulation of DNA replication initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] +subset: gosubset_prok +synonym: "DNA replication licencing" EXACT [] +synonym: "DNA replication licensing" EXACT [] +is_a: GO:0006275 ! regulation of DNA replication +relationship: regulates GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0030175 +name: filopodium +namespace: cellular_component +alt_id: GO:0030028 +def: "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:mah, ISBN:0815316194] +subset: goslim_pir +synonym: "microspike" EXACT [] +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0030176 +name: integral to endoplasmic reticulum membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +synonym: "ER integral membrane protein" EXACT [] +synonym: "integral to ER membrane" EXACT [] +is_a: GO:0031227 ! intrinsic to endoplasmic reticulum membrane +is_a: GO:0031301 ! integral to organelle membrane + +[Term] +id: GO:0030177 +name: positive regulation of Wnt receptor signaling pathway +namespace: biological_process +alt_id: GO:0045811 +def: "Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway activity." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of frizzled signaling pathway" NARROW [] +synonym: "activation of Wnt receptor signaling pathway" NARROW [] +synonym: "positive regulation of frizzled signaling pathway" EXACT [] +synonym: "positive regulation of frizzled signalling pathway" EXACT [] +synonym: "positive regulation of Wnt receptor signalling pathway" EXACT [] +synonym: "stimulation of frizzled signaling pathway" NARROW [] +synonym: "stimulation of Wnt receptor signaling pathway" NARROW [] +synonym: "up regulation of frizzled signaling pathway" EXACT [] +synonym: "up regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "up-regulation of frizzled signaling pathway" EXACT [] +synonym: "up-regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "upregulation of frizzled signaling pathway" EXACT [] +synonym: "upregulation of Wnt receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway +relationship: positively_regulates GO:0016055 ! Wnt receptor signaling pathway + +[Term] +id: GO:0030178 +name: negative regulation of Wnt receptor signaling pathway +namespace: biological_process +alt_id: GO:0045810 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt receptor signaling pathway activity." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of frizzled signaling pathway" EXACT [] +synonym: "down regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "down-regulation of frizzled signaling pathway" EXACT [] +synonym: "down-regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "downregulation of frizzled signaling pathway" EXACT [] +synonym: "downregulation of Wnt receptor signaling pathway" EXACT [] +synonym: "inhibition of frizzled signaling pathway" NARROW [] +synonym: "inhibition of Wnt receptor signaling pathway" NARROW [] +synonym: "negative regulation of frizzled signaling pathway" EXACT [] +synonym: "negative regulation of frizzled signalling pathway" EXACT [] +synonym: "negative regulation of Wnt receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway +relationship: negatively_regulates GO:0016055 ! Wnt receptor signaling pathway + +[Term] +id: GO:0030180 +name: solute:solute exchange +namespace: biological_process +def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah] +comment: This term was made obsolete because it represents a molecular function. +is_obsolete: true +replaced_by: GO:0006810 +replaced_by: GO:0015300 + +[Term] +id: GO:0030181 +name: sodium:calcium exchange +namespace: biological_process +def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a function rather than a process. +is_obsolete: true +replaced_by: GO:0006814 +replaced_by: GO:0006816 +consider: GO:0005432 + +[Term] +id: GO:0030182 +name: neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0030183 +name: B cell differentiation +namespace: biological_process +alt_id: GO:0042115 +def: "The process whereby a precursor cell type acquires the specialized features of a B cell." [GOC:mah, GOC:mtg_15nov05] +comment: This term was improved by GO_REF:0000022. It was moved. +synonym: "B lymphocyte differentiation" EXACT [] +synonym: "B-cell differentiation" EXACT [] +synonym: "B-lymphocyte differentiation" EXACT [] +is_a: GO:0030098 ! lymphocyte differentiation +is_a: GO:0042113 ! B cell activation + +[Term] +id: GO:0030184 +name: nitric oxide transporter activity +namespace: molecular_function +def: "Enables the directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells." [GOC:mah] +subset: gosubset_prok +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0030185 +name: nitric oxide transport +namespace: biological_process +def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells." [GOC:mah] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0030186 +name: melatonin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "melatonin metabolism" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0030187 +name: melatonin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "melatonin anabolism" EXACT [] +synonym: "melatonin biosynthesis" EXACT [] +synonym: "melatonin formation" EXACT [] +synonym: "melatonin synthesis" EXACT [] +is_a: GO:0030186 ! melatonin metabolic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0046219 ! indolalkylamine biosynthetic process + +[Term] +id: GO:0030188 +name: chaperone regulator activity +namespace: molecular_function +def: "Modulates the activity of a molecular chaperone." [GOC:mah] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0030189 +name: chaperone activator activity +namespace: molecular_function +def: "Increases the activity of a molecular chaperone." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030188 ! chaperone regulator activity + +[Term] +id: GO:0030190 +name: chaperone inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0030188 ! chaperone regulator activity + +[Term] +id: GO:0030191 +name: Hsp70/Hsc70 protein inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] +is_a: GO:0030190 ! chaperone inhibitor activity +is_a: GO:0030192 ! Hsp70/Hsc70 protein regulator activity + +[Term] +id: GO:0030192 +name: Hsp70/Hsc70 protein regulator activity +namespace: molecular_function +def: "Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030188 ! chaperone regulator activity + +[Term] +id: GO:0030193 +name: regulation of blood coagulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0050818 ! regulation of coagulation +relationship: regulates GO:0007596 ! blood coagulation + +[Term] +id: GO:0030194 +name: positive regulation of blood coagulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] +synonym: "activation of blood coagulation" NARROW [] +synonym: "stimulation of blood coagulation" NARROW [] +synonym: "up regulation of blood coagulation" EXACT [] +synonym: "up-regulation of blood coagulation" EXACT [] +synonym: "upregulation of blood coagulation" EXACT [] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:0050820 ! positive regulation of coagulation +relationship: positively_regulates GO:0007596 ! blood coagulation + +[Term] +id: GO:0030195 +name: negative regulation of blood coagulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] +synonym: "down regulation of blood coagulation" EXACT [] +synonym: "down-regulation of blood coagulation" EXACT [] +synonym: "downregulation of blood coagulation" EXACT [] +synonym: "inhibition of blood coagulation" NARROW [] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:0050819 ! negative regulation of coagulation +relationship: negatively_regulates GO:0007596 ! blood coagulation + +[Term] +id: GO:0030196 +name: cyanide hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: formamide = cyanide + H2O." [EC:4.2.1.66] +synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66] +synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66] +synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66] +xref: EC:4.2.1.66 +xref: MetaCyc:CYANIDE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0030197 +name: extracellular matrix constituent, lubricant activity +namespace: molecular_function +def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030198 +name: extracellular matrix organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] +subset: gosubset_prok +synonym: "extracellular matrix organisation and biogenesis" EXACT [] +synonym: "extracellular matrix organization and biogenesis" EXACT [] +is_a: GO:0043062 ! extracellular structure organization + +[Term] +id: GO:0030199 +name: collagen fibril organization +namespace: biological_process +def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] +synonym: "collagen fibril organisation" EXACT [] +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0030200 +name: heparan sulfate proteoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "heparan sulfate proteoglycan breakdown" EXACT [] +synonym: "heparan sulfate proteoglycan catabolism" EXACT [] +synonym: "heparan sulfate proteoglycan degradation" EXACT [] +synonym: "heparan sulphate proteoglycan catabolic process" EXACT [] +synonym: "heparan sulphate proteoglycan catabolism" EXACT [] +synonym: "heparin proteoglycan catabolic process" RELATED [] +is_a: GO:0030167 ! proteoglycan catabolic process +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0030201 +name: heparan sulfate proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "heparan sulfate proteoglycan metabolism" EXACT [] +synonym: "heparan sulphate proteoglycan metabolic process" EXACT [] +synonym: "heparan sulphate proteoglycan metabolism" EXACT [] +synonym: "heparin proteoglycan metabolic process" RELATED [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0030202 +name: heparin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "heparan sulfate metabolic process" RELATED [] +synonym: "heparin metabolism" EXACT [] +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0030203 +name: glycosaminoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981] +subset: gosubset_prok +synonym: "glycosaminoglycan metabolism" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process + +[Term] +id: GO:0030204 +name: chondroitin sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chondroitin sulfate metabolism" EXACT [] +synonym: "chondroitin sulphate metabolic process" EXACT [] +synonym: "chondroitin sulphate metabolism" EXACT [] +is_a: GO:0030203 ! glycosaminoglycan metabolic process +relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process + +[Term] +id: GO:0030205 +name: dermatan sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chondroitin sulfate B metabolic process" EXACT [] +synonym: "chondroitin sulfate B metabolism" EXACT [] +synonym: "dermatan sulfate metabolism" EXACT [] +synonym: "dermatan sulphate metabolic process" EXACT [] +synonym: "dermatan sulphate metabolism" EXACT [] +is_a: GO:0030204 ! chondroitin sulfate metabolic process +relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process + +[Term] +id: GO:0030206 +name: chondroitin sulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chondroitin sulfate anabolism" EXACT [] +synonym: "chondroitin sulfate biosynthesis" EXACT [] +synonym: "chondroitin sulfate formation" EXACT [] +synonym: "chondroitin sulfate synthesis" EXACT [] +synonym: "chondroitin sulphate biosynthesis" EXACT [] +synonym: "chondroitin sulphate biosynthetic process" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030204 ! chondroitin sulfate metabolic process +relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0030207 +name: chondroitin sulfate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chondroitin sulfate breakdown" EXACT [] +synonym: "chondroitin sulfate catabolism" EXACT [] +synonym: "chondroitin sulfate degradation" EXACT [] +synonym: "chondroitin sulphate catabolic process" EXACT [] +synonym: "chondroitin sulphate catabolism" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030204 ! chondroitin sulfate metabolic process + +[Term] +id: GO:0030208 +name: dermatan sulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chondroitin sulfate B biosynthesis" EXACT [] +synonym: "chondroitin sulfate B biosynthetic process" EXACT [] +synonym: "dermatan sulfate anabolism" EXACT [] +synonym: "dermatan sulfate biosynthesis" EXACT [] +synonym: "dermatan sulfate formation" EXACT [] +synonym: "dermatan sulfate synthesis" EXACT [] +synonym: "dermatan sulphate biosynthesis" EXACT [] +synonym: "dermatan sulphate biosynthetic process" EXACT [] +is_a: GO:0030205 ! dermatan sulfate metabolic process +is_a: GO:0030206 ! chondroitin sulfate biosynthetic process +relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0030209 +name: dermatan sulfate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chondroitin sulfate B catabolic process" EXACT [] +synonym: "chondroitin sulfate B catabolism" EXACT [] +synonym: "dermatan sulfate breakdown" EXACT [] +synonym: "dermatan sulfate catabolism" EXACT [] +synonym: "dermatan sulfate degradation" EXACT [] +synonym: "dermatan sulphate catabolic process" EXACT [] +synonym: "dermatan sulphate catabolism" EXACT [] +is_a: GO:0030205 ! dermatan sulfate metabolic process +is_a: GO:0030207 ! chondroitin sulfate catabolic process + +[Term] +id: GO:0030210 +name: heparin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "heparan sulfate biosynthetic process" RELATED [] +synonym: "heparin anabolism" EXACT [] +synonym: "heparin biosynthesis" EXACT [] +synonym: "heparin formation" EXACT [] +synonym: "heparin synthesis" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030202 ! heparin metabolic process + +[Term] +id: GO:0030211 +name: heparin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "heparan sulfate catabolic process" RELATED [] +synonym: "heparin breakdown" EXACT [] +synonym: "heparin catabolism" EXACT [] +synonym: "heparin degradation" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030202 ! heparin metabolic process + +[Term] +id: GO:0030212 +name: hyaluronan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hyaluronan metabolism" EXACT [] +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0030213 +name: hyaluronan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hyaluronan anabolism" EXACT [] +synonym: "hyaluronan biosynthesis" EXACT [] +synonym: "hyaluronan formation" EXACT [] +synonym: "hyaluronan synthesis" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030212 ! hyaluronan metabolic process + +[Term] +id: GO:0030214 +name: hyaluronan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hyaluronan breakdown" EXACT [] +synonym: "hyaluronan catabolism" EXACT [] +synonym: "hyaluronan degradation" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030212 ! hyaluronan metabolic process + +[Term] +id: GO:0030215 +name: semaphorin receptor binding +namespace: molecular_function +def: "Interacting selectively with semaphorin receptors." [GOC:ceb, PMID:12001990] +synonym: "plexin binding" NARROW [] +synonym: "plexin ligand" NARROW [] +synonym: "semaphorin receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0030216 +name: keratinocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:mah] +synonym: "keratinocyte cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0030217 +name: T cell differentiation +namespace: biological_process +alt_id: GO:0042112 +alt_id: GO:0046652 +def: "The process by which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GOC:jic, GOC:mah, GOC:mtg_15nov05] +comment: This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. +synonym: "T cell development" EXACT [] +synonym: "T lymphocyte differentiation" EXACT [] +synonym: "T-cell development" EXACT [] +synonym: "T-cell differentiation" EXACT [] +synonym: "T-lymphocyte differentiation" EXACT [] +is_a: GO:0030098 ! lymphocyte differentiation +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0030218 +name: erythrocyte differentiation +namespace: biological_process +def: "The process by which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] +synonym: "erythrocyte cell differentiation" EXACT [] +synonym: "erythropoiesis" EXACT [GOC:adiehl, GOC:dph] +is_a: GO:0030099 ! myeloid cell differentiation +relationship: part_of GO:0034101 ! erythrocyte homeostasis + +[Term] +id: GO:0030219 +name: megakaryocyte differentiation +namespace: biological_process +def: "The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] +synonym: "megakaryocyte cell differentiation" EXACT [] +is_a: GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0030220 +name: platelet formation +namespace: biological_process +def: "The process by which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] +is_a: GO:0030099 ! myeloid cell differentiation +is_a: GO:0048646 ! anatomical structure formation + +[Term] +id: GO:0030221 +name: basophil differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jic, GOC:mah] +synonym: "basophil cell differentiation" EXACT [] +is_a: GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030222 +name: eosinophil differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:mah] +synonym: "eosinophil cell differentiation" EXACT [] +is_a: GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030223 +name: neutrophil differentiation +namespace: biological_process +def: "The process by which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah] +synonym: "neutrophil cell differentiation" EXACT [] +is_a: GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030224 +name: monocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] +synonym: "monocyte cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030225 +name: macrophage differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "macrophage cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030226 +name: apolipoprotein receptor activity +namespace: molecular_function +def: "Combining with an apolipoprotein, the protein component of a lipoprotein, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0004872 ! receptor activity +is_a: GO:0034185 ! apolipoprotein binding + +[Term] +id: GO:0030227 +name: apolipoprotein E receptor activity +namespace: molecular_function +def: "Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah] +synonym: "ApoE receptor" EXACT [] +is_a: GO:0030226 ! apolipoprotein receptor activity +is_a: GO:0034187 ! apolipoprotein E binding + +[Term] +id: GO:0030228 +name: lipoprotein receptor activity +namespace: molecular_function +def: "Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triacylglycerol, cholesterol, or phospholipid, or a combination of these." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0004888 ! transmembrane receptor activity +is_a: GO:0008034 ! lipoprotein binding + +[Term] +id: GO:0030229 +name: very-low-density lipoprotein receptor activity +namespace: molecular_function +def: "Combining with a very-low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "VLDL receptor" EXACT [] +is_a: GO:0030228 ! lipoprotein receptor activity +is_a: GO:0034189 ! very-low-density lipoprotein binding + +[Term] +id: GO:0030232 +name: insulin control element activator complex +namespace: cellular_component +def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390] +synonym: "ICE activator complex" EXACT [] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0030233 +name: deoxynucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0030234 +name: enzyme regulator activity +namespace: molecular_function +def: "Modulates the activity of an enzyme." [GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "catalytic regulator activity" EXACT [GOC:dph] +synonym: "enzyme modulator" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0030235 +name: nitric-oxide synthase regulator activity +namespace: molecular_function +def: "Modulates the activity of nitric oxide synthase." [GOC:mah] +comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. +synonym: "nitric oxide synthase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0030237 +name: female sex determination +namespace: biological_process +def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0030238 +name: male sex determination +namespace: biological_process +def: "The specification of male sex of an individual organism." [GOC:mah] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0030239 +name: myofibril assembly +namespace: biological_process +def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0055002 ! striated muscle cell development + +[Term] +id: GO:0030240 +name: muscle thin filament assembly +namespace: biological_process +def: "Formation of the actin-based thin filaments of myofibrils." [GOC:ef, GOC:mah, GOC:mtg_muscle] +is_a: GO:0007015 ! actin filament organization +relationship: part_of GO:0014866 ! skeletal myofibril assembly + +[Term] +id: GO:0030241 +name: muscle thick filament assembly +namespace: biological_process +def: "Formation of the myosin-based thick filaments of myofibrils." [GOC:ef, GOC:mah, GOC:mtg_muscle] +is_a: GO:0031034 ! myosin filament assembly +relationship: part_of GO:0014866 ! skeletal myofibril assembly + +[Term] +id: GO:0030242 +name: peroxisome degradation +namespace: biological_process +def: "The process by which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [PMID:10547367] +synonym: "pexophagy" EXACT [] +is_a: GO:0006914 ! autophagy +is_a: GO:0007031 ! peroxisome organization + +[Term] +id: GO:0030243 +name: cellulose metabolic process +namespace: biological_process +alt_id: GO:0016177 +def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cellulose metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process + +[Term] +id: GO:0030244 +name: cellulose biosynthetic process +namespace: biological_process +alt_id: GO:0016178 +def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cellulose anabolism" EXACT [] +synonym: "cellulose biosynthesis" EXACT [] +synonym: "cellulose formation" EXACT [] +synonym: "cellulose synthesis" EXACT [] +xref: MetaCyc:PWY-1001 +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0030243 ! cellulose metabolic process + +[Term] +id: GO:0030245 +name: cellulose catabolic process +namespace: biological_process +alt_id: GO:0016179 +def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cellulose breakdown" EXACT [] +synonym: "cellulose catabolism" EXACT [] +synonym: "cellulose degradation" EXACT [] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0030243 ! cellulose metabolic process + +[Term] +id: GO:0030246 +name: carbohydrate binding +namespace: molecular_function +def: "Interacting selectively with any carbohydrate." [GOC:mah] +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "selectin" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0030247 +name: polysaccharide binding +namespace: molecular_function +def: "Interacting selectively with any polysaccharide." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001871 ! pattern binding +is_a: GO:0030246 ! carbohydrate binding + +[Term] +id: GO:0030248 +name: cellulose binding +namespace: molecular_function +def: "Interacting selectively with cellulose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0030249 +name: guanylate cyclase regulator activity +namespace: molecular_function +def: "Modulates the activity of guanylate cyclase." [GOC:mah] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0030250 +name: guanylate cyclase activator activity +namespace: molecular_function +def: "Increases the activity of guanylate cyclase." [GOC:mah] +synonym: "guanylin" EXACT [] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0030249 ! guanylate cyclase regulator activity + +[Term] +id: GO:0030251 +name: guanylate cyclase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0030249 ! guanylate cyclase regulator activity + +[Term] +id: GO:0030252 +name: growth hormone secretion +namespace: biological_process +def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0030253 +name: protein secretion by the type I secretion system +namespace: biological_process +def: "The process by which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'. +synonym: "protein secretion by the TOSS" EXACT [] +synonym: "protein secretion by the type I protein secretion system" EXACT [] +synonym: "type I protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0030254 +name: protein secretion by the type III secretion system +namespace: biological_process +def: "The process by which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. +subset: gosubset_prok +synonym: "protein secretion by the T3S" EXACT [] +synonym: "protein secretion by the T3SS" EXACT [] +synonym: "protein secretion by the TTSS" EXACT [] +synonym: "protein secretion by the type III protein secretion system" EXACT [] +synonym: "type III protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0030255 +name: protein secretion by the type IV secretion system +namespace: biological_process +def: "The process by which nucleoprotein DNA conjugation intermediates or proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'. +subset: gosubset_prok +synonym: "protein secretion by the T4SS" EXACT [] +synonym: "protein secretion by the type IV protein secretion system" EXACT [] +synonym: "type IV protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0030256 +name: type I protein secretion system complex +namespace: cellular_component +def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447] +subset: gosubset_prok +synonym: "ABC translocator complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0030257 +name: type III protein secretion system complex +namespace: cellular_component +def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] +subset: gosubset_prok +synonym: "T3SS complex" EXACT [] +synonym: "TTSS complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0030258 +name: lipid modification +namespace: biological_process +def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah] +subset: gosubset_prok +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0030259 +name: lipid glycosylation +namespace: biological_process +def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0030260 +name: entry into host cell +namespace: biological_process +def: "The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm] +subset: gosubset_prok +synonym: "host cell invasion" EXACT [] +xref: Reactome:173107 +is_a: GO:0044409 ! entry into host +is_a: GO:0051806 ! entry into cell of other organism during symbiotic interaction + +[Term] +id: GO:0030261 +name: chromosome condensation +namespace: biological_process +alt_id: GO:0000068 +def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] +is_a: GO:0006323 ! DNA packaging +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0030262 +name: apoptotic nuclear changes +namespace: biological_process +def: "The morphological and physiological alterations undergone by the nucleus during apoptosis." [GOC:mah] +is_a: GO:0006997 ! nucleus organization +relationship: part_of GO:0008632 ! apoptotic program + +[Term] +id: GO:0030263 +name: apoptotic chromosome condensation +namespace: biological_process +def: "The compaction of chromatin during apoptosis." [GOC:mah] +synonym: "pyknosis" EXACT [] +is_a: GO:0030261 ! chromosome condensation +relationship: part_of GO:0030262 ! apoptotic nuclear changes + +[Term] +id: GO:0030264 +name: nuclear fragmentation during apoptosis +namespace: biological_process +def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:mah, ISBN:0721639976] +synonym: "apoptotic nuclear fragmentation" EXACT [] +synonym: "nucleus fragmentation" EXACT [] +is_a: GO:0006921 ! cell structure disassembly during apoptosis +relationship: part_of GO:0030262 ! apoptotic nuclear changes + +[Term] +id: GO:0030265 +name: rhodopsin mediated G-protein signaling, coupled to IP3 second messenger +namespace: biological_process +def: "The series of molecular signals generated as a consequence of light impinging on rhodopsin molecules in a photoreceptor cell, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah] +synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT [] +synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT [] +synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT [] +is_a: GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) +relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway + +[Term] +id: GO:0030266 +name: quinate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinate + NAD+ = 5-dehydroquinate + NADH + H+." [EC:1.1.1.24] +synonym: "quinate:NAD oxidoreductase activity" EXACT [EC:1.1.1.24] +synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24] +synonym: "quinic dehydrogenase activity" EXACT [EC:1.1.1.24] +xref: EC:1.1.1.24 +xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030267 +name: glyoxylate reductase (NADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] +subset: gosubset_prok +synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79] +synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79] +synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79] +xref: EC:1.1.1.79 +xref: MetaCyc:GLYOXYLATE-REDUCTASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030268 +name: methylenetetrahydromethanopterin dehydrogenase activity +namespace: molecular_function +alt_id: GO:0018536 +def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.9] +subset: gosubset_prok +synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] +synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.9] +synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] +xref: EC:1.5.99.9 +xref: MetaCyc:1.5.99.9-RXN +xref: UM-BBD_enzymeID:e0124 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0030269 +name: tetrahydromethanopterin S-methyltransferase activity +namespace: molecular_function +alt_id: GO:0018709 +def: "Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86] +subset: gosubset_prok +synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86] +synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] +synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] +synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86] +xref: EC:2.1.1.86 +xref: MetaCyc:2.1.1.86-RXN +xref: UM-BBD_enzymeID:e0145 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity + +[Term] +id: GO:0030270 +name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity +namespace: molecular_function +alt_id: GO:0018714 +def: "Catalysis of the reaction: formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + N5-formyl-5,6,7,8-tetrahydromethanopterin." [EC:2.3.1.101] +subset: gosubset_prok +synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] +synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101] +synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101] +synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] +synonym: "FTR" RELATED [EC:2.3.1.101] +synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101] +xref: EC:2.3.1.101 +xref: MetaCyc:2.3.1.101-RXN +xref: UM-BBD_enzymeID:e0143 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0030271 +name: chymase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39] +comment: This term was made obsolete because it represents a gene product. +synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39] +synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39] +synonym: "SK protease activity" EXACT [EC:3.4.21.39] +synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39] +synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39] +synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39] +xref: EC:3.4.21.39 +xref: MetaCyc:3.4.21.39-RXN +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030272 +name: 5-formyltetrahydrofolate cyclo-ligase activity +namespace: molecular_function +alt_id: GO:0019006 +def: "Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate." [EC:6.3.3.2] +subset: gosubset_prok +synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2] +synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2] +synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2] +synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2] +synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2] +synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2] +xref: EC:6.3.3.2 +xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0030273 +name: melanin-concentrating hormone receptor activity +namespace: molecular_function +def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah] +synonym: "MCH receptor" EXACT [] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0030274 +name: LIM domain binding +namespace: molecular_function +def: "Interacting selectively with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030275 +name: LRR domain binding +namespace: molecular_function +def: "Interacting selectively with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030276 +name: clathrin binding +namespace: molecular_function +def: "Interacting selectively with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030277 +name: maintenance of gastrointestinal epithelium +namespace: biological_process +def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah] +is_a: GO:0001894 ! tissue homeostasis +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0030278 +name: regulation of ossification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone formation." [GOC:go_curators] +synonym: "regulation of bone biosynthesis" EXACT [] +synonym: "regulation of bone formation" EXACT [] +is_a: GO:0046850 ! regulation of bone remodeling +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0001503 ! ossification + +[Term] +id: GO:0030279 +name: negative regulation of ossification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone formation." [GOC:go_curators] +synonym: "down regulation of ossification" EXACT [] +synonym: "down-regulation of ossification" EXACT [] +synonym: "downregulation of ossification" EXACT [] +synonym: "inhibition of ossification" NARROW [] +synonym: "negative regulation of bone biosynthesis" EXACT [] +synonym: "negative regulation of bone formation" EXACT [] +is_a: GO:0030278 ! regulation of ossification +is_a: GO:0046851 ! negative regulation of bone remodeling +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0001503 ! ossification + +[Term] +id: GO:0030280 +name: structural constituent of epidermis +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0030281 +name: structural constituent of cutaneous appendage +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437] +is_a: GO:0030280 ! structural constituent of epidermis + +[Term] +id: GO:0030282 +name: bone mineralization +namespace: biological_process +def: "The deposition of calcium phosphate in bone tissue." [GOC:mah] +synonym: "bone calcification" NARROW [] +is_a: GO:0031214 ! biomineral formation +relationship: part_of GO:0001503 ! ossification + +[Term] +id: GO:0030283 +name: 3(or 17)beta-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51] +subset: gosubset_prok +synonym: "17beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51] +synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" EXACT [EC:1.1.1.51] +synonym: "3beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51] +synonym: "3beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.51] +synonym: "beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51] +xref: EC:1.1.1.51 +xref: MetaCyc:1.1.1.51-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030284 +name: estrogen receptor activity +namespace: molecular_function +def: "Combining with estrogen to initiate a change in cell activity." [GOC:ai] +comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0030285 +name: integral to synaptic vesicle membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] +is_a: GO:0031301 ! integral to organelle membrane +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030672 ! synaptic vesicle membrane + +[Term] +id: GO:0030286 +name: dynein complex +namespace: cellular_component +def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] +is_a: GO:0005875 ! microtubule associated complex + +[Term] +id: GO:0030287 +name: cell wall-bounded periplasmic space +namespace: cellular_component +def: "The region between the plasma membrane and the cell wall as found in organisms such as yeast and Gram positive bacteria. These periplasmic spaces are quite thin." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "cell wall bounded periplasmic space" EXACT [] +synonym: "cell wall-enclosed periplasmic space" EXACT [] +synonym: "periplasmic space (sensu Fungi)" NARROW [] +is_a: GO:0042597 ! periplasmic space + +[Term] +id: GO:0030288 +name: outer membrane-bounded periplasmic space +namespace: cellular_component +def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "outer membrane bounded periplasmic space" EXACT [] +synonym: "outer membrane-enclosed periplasmic space" EXACT [] +synonym: "periplasmic space (sensu Gram-negative Bacteria)" EXACT [] +synonym: "periplasmic space (sensu Proteobacteria)" EXACT [] +is_a: GO:0042597 ! periplasmic space +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0030313 ! cell envelope + +[Term] +id: GO:0030289 +name: protein phosphatase 4 complex +namespace: cellular_component +def: "The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit." [PMID:10026142] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0030290 +name: sphingolipid activator protein activity +namespace: molecular_function +def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "saposin" NARROW [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0030291 +name: protein serine/threonine kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity + +[Term] +id: GO:0030292 +name: protein tyrosine kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity + +[Term] +id: GO:0030293 +name: transmembrane receptor protein tyrosine kinase inhibitor activity +namespace: molecular_function +is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity +is_a: GO:0030547 ! receptor inhibitor activity + +[Term] +id: GO:0030294 +name: receptor signaling protein tyrosine kinase inhibitor activity +namespace: molecular_function +synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT [] +is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity + +[Term] +id: GO:0030295 +name: protein kinase activator activity +namespace: molecular_function +def: "Increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0019209 ! kinase activator activity +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0030296 +name: protein tyrosine kinase activator activity +namespace: molecular_function +def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0030297 +name: transmembrane receptor protein tyrosine kinase activator activity +namespace: molecular_function +is_a: GO:0030296 ! protein tyrosine kinase activator activity +is_a: GO:0030546 ! receptor activator activity + +[Term] +id: GO:0030298 +name: receptor signaling protein tyrosine kinase activator activity +namespace: molecular_function +synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT [] +is_a: GO:0030296 ! protein tyrosine kinase activator activity + +[Term] +id: GO:0030299 +name: cholesterol absorption +namespace: biological_process +def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah] +is_a: GO:0050892 ! intestinal absorption +relationship: part_of GO:0044241 ! lipid digestion + +[Term] +id: GO:0030300 +name: regulation of cholesterol absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0030299 ! cholesterol absorption + +[Term] +id: GO:0030301 +name: cholesterol transport +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0015918 ! sterol transport + +[Term] +id: GO:0030302 +name: deoxynucleotide transport +namespace: biological_process +def: "Transport of deoxynucleotides: a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of its deoxyribose moiety." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0030303 +name: stromelysin 2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22] +synonym: "MMP-10" EXACT [] +synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22] +synonym: "transin 2 activity" EXACT [EC:3.4.24.22] +xref: EC:3.4.24.22 +xref: MetaCyc:3.4.24.22-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030304 +name: trypsin inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai] +subset: gosubset_prok +is_a: GO:0004867 ! serine-type endopeptidase inhibitor activity + +[Term] +id: GO:0030305 +name: heparanase activity +namespace: molecular_function +def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150] +synonym: "heparinase activity" RELATED [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0030306 +name: ADP-ribosylation factor binding +namespace: molecular_function +def: "Interacting selectively with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ARF binding" EXACT [] +is_a: GO:0031267 ! small GTPase binding + +[Term] +id: GO:0030307 +name: positive regulation of cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell growth." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of cell growth" NARROW [] +synonym: "stimulation of cell growth" NARROW [] +synonym: "up regulation of cell growth" EXACT [] +synonym: "up-regulation of cell growth" EXACT [] +synonym: "upregulation of cell growth" EXACT [] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:0048522 ! positive regulation of cellular process +relationship: part_of GO:0045793 ! positive regulation of cell size +relationship: positively_regulates GO:0016049 ! cell growth + +[Term] +id: GO:0030308 +name: negative regulation of cell growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell growth." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of cell growth" EXACT [] +synonym: "down-regulation of cell growth" EXACT [] +synonym: "downregulation of cell growth" EXACT [] +synonym: "inhibition of cell growth" NARROW [] +xref: Reactome:110491 +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0016049 ! cell growth +relationship: part_of GO:0045792 ! negative regulation of cell size + +[Term] +id: GO:0030309 +name: poly-N-acetyllactosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] +subset: gosubset_prok +synonym: "poly-N-acetyllactosamine metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0030310 +name: poly-N-acetyllactosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] +subset: gosubset_prok +synonym: "poly-N-acetyllactosamine breakdown" EXACT [] +synonym: "poly-N-acetyllactosamine catabolism" EXACT [] +synonym: "poly-N-acetyllactosamine degradation" EXACT [] +is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0030311 +name: poly-N-acetyllactosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] +subset: gosubset_prok +synonym: "poly-N-acetyllactosamine anabolism" EXACT [] +synonym: "poly-N-acetyllactosamine biosynthesis" EXACT [] +synonym: "poly-N-acetyllactosamine formation" EXACT [] +synonym: "poly-N-acetyllactosamine synthesis" EXACT [] +is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0030312 +name: external encapsulating structure +namespace: cellular_component +def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators] +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0030313 +name: cell envelope +namespace: cellular_component +def: "Everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0030312 ! external encapsulating structure +is_a: GO:0031975 ! envelope + +[Term] +id: GO:0030314 +name: junctional membrane complex +namespace: cellular_component +def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] +synonym: "triad junction" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0016528 ! sarcoplasm + +[Term] +id: GO:0030315 +name: T-tubule +namespace: cellular_component +def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194] +synonym: "transverse tubule" EXACT [] +synonym: "triad" RELATED [] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0042383 ! sarcolemma + +[Term] +id: GO:0030316 +name: osteoclast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12161749] +synonym: "osteoclast cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030317 +name: sperm motility +namespace: biological_process +def: "Any process involved in the controlled movement of a sperm cell." [GOC:jl] +synonym: "sperm movement" EXACT [] +is_a: GO:0006928 ! cell motion + +[Term] +id: GO:0030318 +name: melanocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah] +synonym: "melanocyte cell differentiation" EXACT [] +synonym: "melanophore differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0030319 +name: cellular di-, tri-valent inorganic anion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic anions within a cell or between a cell and its external environment." [GOC:ai] +is_a: GO:0030002 ! cellular anion homeostasis +is_a: GO:0055061 ! di-, tri-valent inorganic anion homeostasis + +[Term] +id: GO:0030320 +name: cellular monovalent inorganic anion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of monovalent inorganic anions within a cell or between a cell and its external environment." [GOC:ai] +is_a: GO:0030002 ! cellular anion homeostasis +is_a: GO:0055083 ! monovalent inorganic anion homeostasis + +[Term] +id: GO:0030321 +name: transepithelial chloride transport +namespace: biological_process +def: "The directed movement of chloride ions across an epithelium." [GOC:mah] +is_a: GO:0006821 ! chloride transport + +[Term] +id: GO:0030322 +name: stabilization of membrane potential +namespace: biological_process +def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0030323 +name: respiratory tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jic] +is_a: GO:0035295 ! tube development +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0030324 +name: lung development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the oesophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0030323 ! respiratory tube development + +[Term] +id: GO:0030325 +name: adrenal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] +synonym: "interrenal gland" RELATED [] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0030326 +name: embryonic limb morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172] +is_a: GO:0035108 ! limb morphogenesis +is_a: GO:0035113 ! embryonic appendage morphogenesis + +[Term] +id: GO:0030327 +name: prenylated protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah] +subset: gosubset_prok +synonym: "prenylated protein breakdown" EXACT [] +synonym: "prenylated protein catabolism" EXACT [] +synonym: "prenylated protein degradation" EXACT [] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0030328 +name: prenylcysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] +subset: gosubset_prok +synonym: "prenylcysteine breakdown" EXACT [] +synonym: "prenylcysteine catabolism" EXACT [] +synonym: "prenylcysteine degradation" EXACT [] +is_a: GO:0030327 ! prenylated protein catabolic process +is_a: GO:0030329 ! prenylcysteine metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0030329 +name: prenylcysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "prenylcysteine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0030330 +name: DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +alt_id: GO:0006976 +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators] +synonym: "DNA damage response, activation of p53" RELATED [] +synonym: "p53-mediated DNA damage response" BROAD [] +is_a: GO:0042770 ! DNA damage response, signal transduction + +[Term] +id: GO:0030331 +name: estrogen receptor binding +namespace: molecular_function +def: "Interacting selectively with an estrogen receptor." [GOC:ai] +is_a: GO:0035258 ! steroid hormone receptor binding + +[Term] +id: GO:0030332 +name: cyclin binding +namespace: molecular_function +def: "Interacting selectively with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030334 +name: regulation of cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0051270 ! regulation of cell motion +relationship: regulates GO:0016477 ! cell migration + +[Term] +id: GO:0030335 +name: positive regulation of cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of cell migration" NARROW [] +synonym: "stimulation of cell migration" NARROW [] +synonym: "up regulation of cell migration" EXACT [] +synonym: "up-regulation of cell migration" EXACT [] +synonym: "upregulation of cell migration" EXACT [] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0051272 ! positive regulation of cell motion +relationship: positively_regulates GO:0016477 ! cell migration + +[Term] +id: GO:0030336 +name: negative regulation of cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] +synonym: "down regulation of cell migration" EXACT [] +synonym: "down-regulation of cell migration" EXACT [] +synonym: "downregulation of cell migration" EXACT [] +synonym: "inhibition of cell migration" NARROW [] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0051271 ! negative regulation of cell motion +relationship: negatively_regulates GO:0016477 ! cell migration + +[Term] +id: GO:0030337 +name: DNA polymerase processivity factor activity +namespace: molecular_function +def: "An accessory subunit of DNA polymerase that acts to increase the processivity of polymerization." [UniProtKB:P28958] +subset: gosubset_prok +synonym: "processivity clamp" EXACT [] +synonym: "sliding clamp" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0030338 +name: CMP-N-acetylneuraminate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2] +comment: Note that this was EC:1.14.13.45. +synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2] +synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2] +synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT [] +synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2] +synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2] +synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2] +synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2] +xref: EC:1.14.18.2 +xref: MetaCyc:1.14.13.45-RXN +is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0030339 +name: fatty-acyl-ethyl-ester synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67] +synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67] +synonym: "FAEES activity" EXACT [EC:3.1.1.67] +synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67] +xref: EC:3.1.1.67 +xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0030340 +name: hyaluronate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1] +subset: gosubset_prok +synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1] +synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1] +synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1] +synonym: "mucinase activity" EXACT [EC:4.2.2.1] +synonym: "spreading factor activity" RELATED [EC:4.2.2.1] +xref: EC:4.2.2.1 +xref: MetaCyc:HYALURONATE-LYASE-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0030341 +name: chondroitin AC lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5] +subset: gosubset_prok +synonym: "ChnAC" RELATED [] +synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5] +synonym: "chondroitin lyase activity" EXACT [] +synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5] +synonym: "chondroitinase AC" RELATED [] +synonym: "chondroitinase activity" BROAD [] +xref: EC:4.2.2.5 +xref: MetaCyc:4.2.2.5-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0030342 +name: 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of C-1 of 25-hydroxycalciferol (25-hydroxyvitamin D3) to form 1-alpha,25-dihydroxycalciferol." [ISBN:0471331309 "Biochemical Pathways"] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0030343 +name: vitamin D3 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of C-25 of calciferol (vitamin D3) to form 25-hydroxycalciferol." [ISBN:0471331309 "Biochemical Pathways"] +synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0030345 +name: structural constituent of tooth enamel +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah] +is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance + +[Term] +id: GO:0030346 +name: protein phosphatase 2B binding +namespace: molecular_function +def: "Interacting selectively with the enzyme protein phosphatase 2B." [GOC:jl] +synonym: "calcineurin binding" EXACT [] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:0030347 +name: syntaxin-2 binding +namespace: molecular_function +def: "Interacting selectively with the SNAP receptor syntaxin-2." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0030348 +name: syntaxin-3 binding +namespace: molecular_function +def: "Interacting selectively with the SNAP receptor syntaxin-3." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0030349 +name: syntaxin-13 binding +namespace: molecular_function +def: "Interacting selectively with the SNAP receptor syntaxin-13." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0030350 +name: iron-responsive element binding +namespace: molecular_function +def: "Interacting selectively with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] +synonym: "IRE binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0030351 +name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] +xref: EC:3.1.3.- +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0030352 +name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] +xref: EC:3.1.3.- +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0030353 +name: fibroblast growth factor receptor antagonist activity +namespace: molecular_function +def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah] +synonym: "FGF receptor antagonist activity" EXACT [] +synonym: "FGFR antagonist activity" EXACT [] +is_a: GO:0005104 ! fibroblast growth factor receptor binding +is_a: GO:0048019 ! receptor antagonist activity + +[Term] +id: GO:0030354 +name: melanin-concentrating hormone activity +namespace: molecular_function +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0030355 +name: small nucleolar ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "snoRNP" EXACT [] +is_obsolete: true +replaced_by: GO:0005732 + +[Term] +id: GO:0030356 +name: small cytoplasmic ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "scRNP" EXACT [] +is_obsolete: true +replaced_by: GO:0030531 + +[Term] +id: GO:0030359 +name: protein phosphatase type 2B regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme protein phosphatase type 2B." [GOC:ai] +synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0030362 +name: protein phosphatase type 4 regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme protein phosphatase type 4." [GOC:ai] +synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0030363 +name: pre-mRNA cleavage factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856] +comment: This term was made obsolete because it describes a biological process. +is_obsolete: true +consider: GO:0006379 + +[Term] +id: GO:0030364 +name: cleavage and polyadenylylation specificity factor activity +namespace: molecular_function +def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856] +comment: This term was made obsolete because it describes a cellular component. +synonym: "cleavage and polyadenylation specificity factor activity" EXACT [] +synonym: "cleavage/polyadenylation specificity factor activity" EXACT [] +synonym: "CPSF" EXACT [] +is_obsolete: true +replaced_by: GO:0005847 +consider: GO:0006378 +consider: GO:0006379 + +[Term] +id: GO:0030365 +name: cleavage stimulation factor activity +namespace: molecular_function +def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856] +comment: This term was made obsolete because it describes a cellular component. +synonym: "CstF" EXACT [] +is_obsolete: true +replaced_by: GO:0005848 +consider: GO:0006379 + +[Term] +id: GO:0030366 +name: Mo-molybdopterin synthase activity +namespace: molecular_function +def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:8514783] +synonym: "molybdopterin synthase activity" EXACT [] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0030367 +name: interleukin-17 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-17 receptor." [GOC:ai] +synonym: "IL-17" NARROW [] +synonym: "interleukin-17 receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0030368 +name: interleukin-17 receptor activity +namespace: molecular_function +def: "Combining with interleukin-17 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-17R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0019975 ! interleukin-17 binding + +[Term] +id: GO:0030369 +name: ICAM-3 receptor activity +namespace: molecular_function +def: "Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0030370 +name: intercellular adhesion molecule-3 receptor binding +namespace: molecular_function +def: "Interacting selectively with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836] +synonym: "ICAM-3 receptor binding" EXACT [] +synonym: "ICAM-3 receptor ligand" NARROW [] +synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0030371 +name: translation repressor activity +namespace: molecular_function +def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt] +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0030372 +name: high molecular weight B cell growth factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the high molecular weight B cell growth factor receptor." [GOC:ai] +synonym: "high molecular weight B cell growth factor receptor ligand" NARROW [] +synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT [] +synonym: "high molecular weight B-cell growth factor receptor binding" EXACT [] +synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0030373 +name: high molecular weight B cell growth factor receptor activity +namespace: molecular_function +def: "Combining with a high molecular weight B cell growth factor to initiate a change in cell activity." [GOC:ai] +synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT [] +synonym: "high molecular weight B-cell growth factor receptor activity" EXACT [] +synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0030374 +name: ligand-dependent nuclear receptor transcription coactivator activity +namespace: molecular_function +synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT [] +is_a: GO:0003713 ! transcription coactivator activity + +[Term] +id: GO:0030375 +name: thyroid hormone receptor coactivator activity +namespace: molecular_function +synonym: "thyroid hormone receptor co-activator activity" EXACT [] +is_a: GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity + +[Term] +id: GO:0030377 +name: U-plasminogen activator receptor activity +namespace: molecular_function +synonym: "uPAR" EXACT [] +synonym: "urokinase plasminogen activator receptor" EXACT [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0030378 +name: serine racemase activity +namespace: molecular_function +def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0030379 +name: neurotensin receptor activity, non-G-protein coupled +namespace: molecular_function +synonym: "neurotensin receptor activity, non G protein coupled" EXACT [] +synonym: "non G protein coupled neurotensin receptor activity" EXACT [] +synonym: "non-G-protein coupled neurotensin receptor activity" EXACT [] +synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0030380 +name: interleukin-17E receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-17E receptor." [GOC:ai] +synonym: "IL-17E" NARROW [] +synonym: "interleukin-17E receptor ligand" NARROW [] +is_a: GO:0005126 ! hematopoietin/interferon-class (D200-domain) cytokine receptor binding + +[Term] +id: GO:0030381 +name: chorion-containing eggshell pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] +synonym: "eggshell pattern formation (sensu Insecta)" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007304 ! chorion-containing eggshell formation + +[Term] +id: GO:0030382 +name: sperm mitochondrion organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of sperm mitochondria; the process by which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] +synonym: "sperm mitochondria organisation and biogenesis" EXACT [] +synonym: "sperm mitochondria organization and biogenesis" EXACT [] +synonym: "sperm mitochondrion organization and biogenesis" EXACT [] +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0030383 +name: host-pathogen interaction +namespace: biological_process +def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl] +comment: This term was made obsolete because more appropriate terms were created. +is_obsolete: true +consider: GO:0044403 + +[Term] +id: GO:0030384 +name: phosphoinositide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphoinositide metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0030385 +name: ferredoxin:thioredoxin reductase activity +namespace: molecular_function +def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790] +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0030386 +name: ferredoxin:thioredoxin reductase complex +namespace: cellular_component +def: "A protein complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0030387 +name: fructosamine-3-kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase." [PMID:11016445] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0030388 +name: fructose 1,6-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fructose 1,6-bisphosphate metabolism" EXACT [] +is_a: GO:0006000 ! fructose metabolic process + +[Term] +id: GO:0030389 +name: fructosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "fructosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process + +[Term] +id: GO:0030391 +name: fructosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "fructosamine anabolism" EXACT [] +synonym: "fructosamine biosynthesis" EXACT [] +synonym: "fructosamine formation" EXACT [] +synonym: "fructosamine synthesis" EXACT [] +is_a: GO:0030389 ! fructosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0030392 +name: fructosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "fructosamine breakdown" EXACT [] +synonym: "fructosamine catabolism" EXACT [] +synonym: "fructosamine degradation" EXACT [] +is_a: GO:0030389 ! fructosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0030393 +name: fructoselysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine moiety in place of a hydroxyl group." [GOC:ai] +subset: gosubset_prok +synonym: "fructoselysine metabolism" EXACT [] +is_a: GO:0030389 ! fructosamine metabolic process + +[Term] +id: GO:0030394 +name: fructoseglycine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine moiety in place of a hydroxyl group." [GOC:ai] +subset: gosubset_prok +synonym: "fructoseglycine metabolism" EXACT [] +is_a: GO:0030389 ! fructosamine metabolic process + +[Term] +id: GO:0030395 +name: lactose binding +namespace: molecular_function +def: "Interacting selectively with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X] +is_a: GO:0048030 ! disaccharide binding + +[Term] +id: GO:0030397 +name: membrane disassembly +namespace: biological_process +def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] +synonym: "membrane breakdown" EXACT [] +synonym: "membrane catabolism" EXACT [] +synonym: "membrane degradation" EXACT [] +is_a: GO:0016044 ! membrane organization +is_a: GO:0022411 ! cellular component disassembly + +[Term] +id: GO:0030398 +name: peroxisomal membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760] +synonym: "peroxisomal membrane breakdown" EXACT [] +synonym: "peroxisomal membrane catabolism" EXACT [] +synonym: "peroxisomal membrane degradation" EXACT [] +is_a: GO:0030397 ! membrane disassembly +relationship: part_of GO:0030242 ! peroxisome degradation + +[Term] +id: GO:0030399 +name: autophagic membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the membranes of autophagic vacuoles." [GOC:mah] +synonym: "autophagic membrane breakdown" EXACT [] +synonym: "autophagic membrane catabolism" EXACT [] +synonym: "autophagic membrane degradation" EXACT [] +is_a: GO:0030397 ! membrane disassembly +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0030400 +name: protease substrate recruitment factor activity +namespace: molecular_function +def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0030674 + +[Term] +id: GO:0030401 +name: transcription antiterminator activity +namespace: molecular_function +def: "Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "transcriptional antiterminator activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0030402 +name: matrilysin-2 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 26" EXACT [] +synonym: "MMP-26" EXACT [] +xref: EC:3.4.24.- +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030403 +name: collagenase 4 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 18" EXACT [] +synonym: "MMP-18" NARROW [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030404 +name: collagenase 3 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 13" EXACT [] +synonym: "MMP-13" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030405 +name: matrix metalloproteinase 19 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "MMP-19" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030406 +name: matrix metalloproteinase 25 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "MMP-25" EXACT [] +synonym: "MT6-MMP" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030407 +name: formimidoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah] +subset: gosubset_prok +synonym: "formiminotransferase activity" EXACT [] +xref: EC:2.1.2.- +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0030408 +name: glycine formimidoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4] +synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4] +synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4] +synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4] +synonym: "glycine formiminotransferase activity" EXACT [] +xref: EC:2.1.2.4 +xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN +is_a: GO:0030407 ! formimidoyltransferase activity + +[Term] +id: GO:0030409 +name: glutamate formimidoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5] +subset: gosubset_prok +synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5] +synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5] +synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5] +synonym: "glutamate formiminotransferase activity" EXACT [] +synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5] +xref: EC:2.1.2.5 +xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN +is_a: GO:0030407 ! formimidoyltransferase activity + +[Term] +id: GO:0030410 +name: nicotianamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine = 3 5'-S-methyl-5'-thioadenosine + nicotianamine." [EC:2.5.1.43] +subset: gosubset_prok +synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43] +xref: EC:2.5.1.43 +xref: MetaCyc:2.5.1.43-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0030411 +name: scytalone dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O." [EC:4.2.1.94] +synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94] +synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94] +xref: EC:4.2.1.94 +xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0030412 +name: formimidoyltetrahydrofolate cyclodeaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3." [EC:4.3.1.4] +subset: gosubset_prok +synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4] +synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4] +synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4] +xref: EC:4.3.1.4 +xref: MetaCyc:4.3.1.4-RXN +xref: Reactome:23291 +is_a: GO:0016841 ! ammonia-lyase activity +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0030413 +name: competence pheromone activity +namespace: molecular_function +def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645] +subset: gosubset_prok +is_a: GO:0005186 ! pheromone activity + +[Term] +id: GO:0030414 +name: protease inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds." [GOC:jl] +subset: gosubset_prok +synonym: "peptidase inhibitor" EXACT [] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0030415 +name: carboxypeptidase A inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai] +is_a: GO:0030414 ! protease inhibitor activity + +[Term] +id: GO:0030416 +name: methylamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylamine (CH3NH2), a flammable, explosive gas, used in tanning and in organic synthesis and produced naturally in some decaying fish, certain plants, and crude methanol." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "methylamine metabolism" EXACT [] +synonym: "methylammonium metabolic process" EXACT [] +synonym: "methylammonium metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0030417 +name: nicotianamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] +subset: gosubset_prok +synonym: "nicotianamine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process + +[Term] +id: GO:0030418 +name: nicotianamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] +subset: gosubset_prok +synonym: "nicotianamine anabolism" EXACT [] +synonym: "nicotianamine biosynthesis" EXACT [] +synonym: "nicotianamine formation" EXACT [] +synonym: "nicotianamine synthesis" EXACT [] +is_a: GO:0030417 ! nicotianamine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0030419 +name: nicotianamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] +subset: gosubset_prok +synonym: "nicotianamine breakdown" EXACT [] +synonym: "nicotianamine catabolism" EXACT [] +synonym: "nicotianamine degradation" EXACT [] +is_a: GO:0030417 ! nicotianamine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0030420 +name: establishment of competence for transformation +namespace: biological_process +def: "The process by which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027] +subset: gosubset_prok +is_a: GO:0031668 ! cellular response to extracellular stimulus +relationship: part_of GO:0009294 ! DNA mediated transformation + +[Term] +id: GO:0030421 +name: defecation +namespace: biological_process +def: "The expulsion of feces from the rectum." [GOC:mah] +is_a: GO:0007588 ! excretion + +[Term] +id: GO:0030422 +name: RNA interference, production of siRNA +namespace: biological_process +def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides." [PMID:11524674] +synonym: "RNA interference, production of guide RNAs" EXACT [] +is_a: GO:0031050 ! dsRNA fragmentation +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0030423 +name: RNA interference, targeting of mRNA for destruction +namespace: biological_process +def: "The process by which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0030424 +name: axon +namespace: cellular_component +def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0030425 +name: dendrite +namespace: cellular_component +def: "A branching protoplasmic process of a neuron that receive and integrate signals coming from axons of other neurons, and convey the resulting signal to the body of the cell." [GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0030426 +name: growth cone +namespace: cellular_component +def: "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194] +is_a: GO:0030427 ! site of polarized growth + +[Term] +id: GO:0030427 +name: site of polarized growth +namespace: cellular_component +alt_id: GO:0000134 +alt_id: GO:0030483 +def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +synonym: "site of polarized growth (sensu Fungi)" EXACT [] +synonym: "site of polarized growth (sensu Saccharomyces)" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0030428 +name: cell septum +namespace: cellular_component +def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] +subset: goslim_pir +subset: gosubset_prok +synonym: "cross wall" EXACT [] +synonym: "septum" BROAD [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0030429 +name: kynureninase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3] +subset: gosubset_prok +synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3] +synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] +synonym: "l-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] +xref: EC:3.7.1.3 +xref: MetaCyc:KYNURENINASE-RXN +xref: Reactome:23316 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0030430 +name: host cell cytoplasm +namespace: cellular_component +def: "The cytoplasm of a host cell." [GOC:mah] +subset: gosubset_prok +is_a: GO:0033646 ! host intracellular part +relationship: part_of GO:0043656 ! intracellular region of host + +[Term] +id: GO:0030431 +name: sleep +namespace: biological_process +def: "Any process by which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] +subset: goslim_pir +synonym: "diapause" RELATED [] +synonym: "dormancy" RELATED [] +synonym: "lethargus" RELATED [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0030432 +name: peristalsis +namespace: biological_process +def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0014821 ! phasic smooth muscle contraction + +[Term] +id: GO:0030433 +name: ER-associated protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of unfolded or misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [GOC:mah, PMID:14607247] +comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. +synonym: "endoplasmic reticulum-associated protein catabolic process" EXACT [] +synonym: "endoplasmic reticulum-associated protein catabolism" EXACT [] +synonym: "ER-associated protein breakdown" EXACT [] +synonym: "ER-associated protein catabolism" EXACT [] +synonym: "ER-associated protein degradation" EXACT [] +synonym: "ERAD" EXACT [] +is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process +is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0030435 +name: sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "The process by which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_08, ISBN:0072992913] +comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. +subset: goslim_yeast +subset: gosubset_prok +synonym: "spore biosynthesis" EXACT [] +synonym: "spore differentiation" EXACT [] +synonym: "spore formation" EXACT [] +is_a: GO:0030154 ! cell differentiation +is_a: GO:0043934 ! sporulation + +[Term] +id: GO:0030436 +name: asexual sporulation +namespace: biological_process +def: "The formation of spores derived from the products of mitosis." [GOC:mah, PMID:9529886] +subset: gosubset_prok +synonym: "asexual spore formation" EXACT [] +synonym: "mitotic spore formation" EXACT [] +synonym: "mitotic sporulation" EXACT [] +synonym: "spore formation (sensu Bacteria)" NARROW [] +synonym: "sporulation (sensu Bacteria)" NARROW [] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0043934 ! sporulation + +[Term] +id: GO:0030437 +name: ascospore formation +namespace: biological_process +alt_id: GO:0007151 +def: "The process by which a diploid cell undergoes meiosis, and the meiotic products acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:mah, PMID:16339736] +synonym: "ascospore biosynthesis" EXACT [] +synonym: "spore formation (sensu Fungi)" BROAD [] +synonym: "sporulation (sensu Fungi)" BROAD [] +synonym: "sporulation (sensu Saccharomyces)" EXACT [] +is_a: GO:0022413 ! reproductive process in single-celled organism +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0030438 +name: MAPKKK cascade during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0030439 +name: activation of MAPK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0030440 +name: activation of MAPKK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0030441 +name: activation of MAPKKK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0030442 +name: inactivation of MAPK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0030443 +name: nuclear translocation of MAPK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true + +[Term] +id: GO:0030444 +name: microtubule depolymerization during nuclear congression +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because the entire branch of the ontology was changed. +is_obsolete: true +replaced_by: GO:0007019 + +[Term] +id: GO:0030445 +name: yeast-form cell wall +namespace: cellular_component +def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc] +comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. +is_a: GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0030446 +name: hyphal cell wall +namespace: cellular_component +def: "The cell wall surrounding a fungal hypha." [GOC:mah] +comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'. +is_a: GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0030447 +name: filamentous growth +namespace: biological_process +def: "The process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] +subset: goslim_candida +is_a: GO:0040007 ! growth + +[Term] +id: GO:0030448 +name: hyphal growth +namespace: biological_process +def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] +subset: goslim_candida +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0030449 +name: regulation of complement activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0030162 ! regulation of proteolysis +relationship: regulates GO:0006956 ! complement activation + +[Term] +id: GO:0030450 +name: regulation of complement activation, classical pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators] +is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin +is_a: GO:0030449 ! regulation of complement activation +relationship: regulates GO:0006958 ! complement activation, classical pathway + +[Term] +id: GO:0030451 +name: regulation of complement activation, alternative pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators] +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0006957 ! complement activation, alternative pathway + +[Term] +id: GO:0030452 +name: group I intron catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an excised group I intron." [GOC:mah] +subset: gosubset_prok +synonym: "group I intron breakdown" EXACT [] +synonym: "group I intron catabolism" EXACT [] +synonym: "group I intron degradation" EXACT [] +is_a: GO:0000292 ! RNA fragment catabolic process + +[Term] +id: GO:0030455 +name: MAPKKK cascade (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030456 +name: activation of MAPK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030457 +name: activation of MAPKK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030458 +name: activation of MAPKKK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030459 +name: inactivation of MAPK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030460 +name: nuclear translocation of MAPK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030463 +name: cell aging (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. +is_obsolete: true +replaced_by: GO:0007569 + +[Term] +id: GO:0030464 +name: aging dependent sterility (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] +comment: This term was made obsolete because it reflected a trait or phenotype. +is_obsolete: true +consider: GO:0030466 + +[Term] +id: GO:0030465 +name: autophagic death (sensu Fungi) +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because a more correct term has been created. +is_obsolete: true +consider: GO:0048102 + +[Term] +id: GO:0030466 +name: chromatin silencing at silent mating-type cassette +namespace: biological_process +alt_id: GO:0006347 +def: "Repression of transcription at silent mating-type loci by the formation of heterochromatin." [GOC:mcc] +synonym: "aging-dependent sterility (sensu Fungi)" RELATED [] +synonym: "aging-dependent sterility (sensu Saccharomyces)" RELATED [] +synonym: "chromatin silencing at HML and HMR (sensu Saccharomyces)" NARROW [] +synonym: "chromatin silencing at silent mating-type cassette (sensu Fungi)" EXACT [] +synonym: "heterochromatic silencing at silent mating-type cassette" EXACT [] +is_a: GO:0006342 ! chromatin silencing + +[Term] +id: GO:0030470 +name: spore germination (sensu Fungi) +namespace: biological_process +alt_id: GO:0007153 +def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc] +comment: This term was made obsolete because a sensu term was not needed. +synonym: "germination (sensu Saccharomyces)" NARROW [] +is_obsolete: true +replaced_by: GO:0009847 + +[Term] +id: GO:0030471 +name: spindle pole body and microtubule cycle (sensu Fungi) +namespace: biological_process +alt_id: GO:0007102 +def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649] +comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful concept. +synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW [] +is_obsolete: true +consider: GO:0007051 +consider: GO:0051300 + +[Term] +id: GO:0030472 +name: mitotic spindle organization in nucleus +namespace: biological_process +alt_id: GO:0000071 +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus during a mitotic cell cycle, as seen in Fungi." [GOC:mah] +synonym: "mitotic spindle assembly (sensu Fungi)" NARROW [] +synonym: "mitotic spindle assembly (sensu Saccharomyces)" NARROW [] +synonym: "mitotic spindle organisation and biogenesis in nucleus" EXACT [] +synonym: "mitotic spindle organization and biogenesis in cell nucleus" EXACT [] +synonym: "mitotic spindle organization and biogenesis in nucleus" EXACT [] +synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT [] +is_a: GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0030473 +name: nuclear migration along microtubule +namespace: biological_process +alt_id: GO:0000065 +def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] +synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] +synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] +synonym: "microtubule-dependent nuclear positioning" EXACT [] +synonym: "microtubule-dependent nucleus positioning" EXACT [] +synonym: "microtubule-mediated nuclear migration" EXACT [] +synonym: "nuclear migration (sensu Fungi)" NARROW [] +synonym: "nuclear migration (sensu Saccharomyces)" NARROW [] +synonym: "nuclear migration, microtubule-mediated" EXACT [] +synonym: "nuclear movement, microtubule-mediated" BROAD [] +synonym: "nucleus migration (sensu Fungi)" NARROW [] +synonym: "nucleus migration (sensu Saccharomyces)" NARROW [] +synonym: "transport of nucleus by microtubules" EXACT [] +synonym: "transport of nucleus, microtubule-mediated" EXACT [] +is_a: GO:0007018 ! microtubule-based movement +is_a: GO:0007097 ! nuclear migration + +[Term] +id: GO:0030474 +name: spindle pole body duplication +namespace: biological_process +def: "Construction of a new spindle pole body." [GOC:clt] +synonym: "spindle pole body assembly" EXACT [] +synonym: "spindle pole body biogenesis" EXACT [] +synonym: "spindle pole body biosynthesis" EXACT [] +synonym: "spindle pole body duplication (sensu Fungi)" EXACT [] +synonym: "spindle pole body formation" EXACT [] +synonym: "spindle pole body replication" EXACT [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051300 ! spindle pole body organization + +[Term] +id: GO:0030476 +name: ascospore wall assembly +namespace: biological_process +alt_id: GO:0007152 +def: "The process by which the ascospore nucleus becomes surrounded by a specialized spore wall. Occurs by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane." [GOC:mcc, PMID:14702385] +synonym: "spore wall assembly (sensu Fungi)" EXACT [] +synonym: "spore wall assembly (sensu Saccharomyces)" NARROW [] +is_a: GO:0042244 ! spore wall assembly +relationship: part_of GO:0030437 ! ascospore formation + +[Term] +id: GO:0030478 +name: actin cap +namespace: cellular_component +alt_id: GO:0000143 +def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell." [GOC:mah, ISBN:10652251] +synonym: "actin cap (sensu Fungi)" EXACT [] +synonym: "actin cap (sensu Saccharomyces)" NARROW [] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0030479 +name: actin cortical patch +namespace: cellular_component +alt_id: GO:0005857 +def: "A discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] +synonym: "actin cortical patch (sensu Fungi)" EXACT [] +synonym: "actin cortical patch (sensu Saccharomyces)" NARROW [] +synonym: "actin patch" EXACT [] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0030482 +name: actin cable +namespace: cellular_component +alt_id: GO:0000141 +def: "A long bundle of actin filaments, comprising filamentous actin and associated proteins, found in cells." [ISBN:0879693649] +synonym: "actin cable (sensu Fungi)" EXACT [] +synonym: "actin cable (sensu Saccharomyces)" EXACT [] +is_a: GO:0032432 ! actin filament bundle + +[Term] +id: GO:0030484 +name: muscle fiber +namespace: cellular_component +def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194] +comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. +synonym: "muscle fibre" EXACT [] +is_obsolete: true +replaced_by: GO:0043292 + +[Term] +id: GO:0030485 +name: smooth muscle contractile fiber +namespace: cellular_component +def: "The contractile fiber of smooth muscle cells." [GOC:mah] +synonym: "smooth muscle fiber" BROAD [] +synonym: "smooth muscle fibre" EXACT [] +is_a: GO:0043292 ! contractile fiber +is_a: GO:0044449 ! contractile fiber part + +[Term] +id: GO:0030486 +name: smooth muscle dense body +namespace: cellular_component +def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0030485 ! smooth muscle contractile fiber + +[Term] +id: GO:0030487 +name: inositol-4,5-bisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of a phosphate group from the carbon-5 position of D-myo-inositol 4,5-bisphosphate." [GOC:mah] +is_a: GO:0016312 ! inositol bisphosphate phosphatase activity + +[Term] +id: GO:0030488 +name: tRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001510 ! RNA methylation +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0030489 +name: processing of 27S pre-rRNA +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] +comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product. +is_obsolete: true + +[Term] +id: GO:0030490 +name: maturation of SSU-rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] +synonym: "processing of 20S pre-rRNA" NARROW [] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0030491 +name: heteroduplex formation +namespace: biological_process +def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855] +xref: Reactome:76007 +xref: Reactome:76008 +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0030492 +name: hemoglobin binding +namespace: molecular_function +def: "Interacting selectively with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "globin binding" NARROW [] +synonym: "haemoglobin binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030493 +name: bacteriochlorophyll metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "bacteriochlorophyll metabolism" EXACT [] +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0030494 +name: bacteriochlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "bacteriochlorophyll anabolism" EXACT [] +synonym: "bacteriochlorophyll biosynthesis" EXACT [] +synonym: "bacteriochlorophyll formation" EXACT [] +synonym: "bacteriochlorophyll synthesis" EXACT [] +is_a: GO:0015995 ! chlorophyll biosynthetic process +is_a: GO:0030493 ! bacteriochlorophyll metabolic process + +[Term] +id: GO:0030495 +name: bacteriochlorophyll catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators] +subset: gosubset_prok +synonym: "bacteriochlorophyll breakdown" EXACT [] +synonym: "bacteriochlorophyll catabolism" EXACT [] +synonym: "bacteriochlorophyll degradation" EXACT [] +is_a: GO:0015996 ! chlorophyll catabolic process +is_a: GO:0030493 ! bacteriochlorophyll metabolic process + +[Term] +id: GO:0030496 +name: midbody +namespace: cellular_component +def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] +subset: goslim_pir +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0030497 +name: fatty acid elongation +namespace: biological_process +def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] +subset: gosubset_prok +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0030500 +name: regulation of bone mineralization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators] +is_a: GO:0030278 ! regulation of ossification +relationship: regulates GO:0030282 ! bone mineralization + +[Term] +id: GO:0030501 +name: positive regulation of bone mineralization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators] +synonym: "activation of bone mineralization" NARROW [] +synonym: "stimulation of bone mineralization" NARROW [] +synonym: "up regulation of bone mineralization" EXACT [] +synonym: "up-regulation of bone mineralization" EXACT [] +synonym: "upregulation of bone mineralization" EXACT [] +is_a: GO:0030500 ! regulation of bone mineralization +is_a: GO:0045778 ! positive regulation of ossification +relationship: positively_regulates GO:0030282 ! bone mineralization + +[Term] +id: GO:0030502 +name: negative regulation of bone mineralization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators] +synonym: "down regulation of bone mineralization" EXACT [] +synonym: "down-regulation of bone mineralization" EXACT [] +synonym: "downregulation of bone mineralization" EXACT [] +synonym: "inhibition of bone mineralization" NARROW [] +is_a: GO:0030279 ! negative regulation of ossification +is_a: GO:0030500 ! regulation of bone mineralization +relationship: negatively_regulates GO:0030282 ! bone mineralization + +[Term] +id: GO:0030504 +name: inorganic diphosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of inorganic diphosphate across a membrane." [PMID:11326272] +synonym: "inorganic pyrophosphate transporter" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0030505 +name: inorganic diphosphate transport +namespace: biological_process +def: "The directed movement of inorganic diphosphate into, out of, within or between cells." [GOC:mah] +synonym: "inorganic pyrophosphate transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0030506 +name: ankyrin binding +namespace: molecular_function +def: "Interacting selectively with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0030507 +name: spectrin binding +namespace: molecular_function +def: "Interacting selectively with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0030508 +name: thiol-disulfide exchange intermediate activity +namespace: molecular_function +def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah] +comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process. +subset: gosubset_prok +synonym: "glutaredoxin" NARROW [] +synonym: "thiol-disulphide exchange intermediate activity" EXACT [] +synonym: "thioredoxin" NARROW [] +is_obsolete: true +consider: GO:0006467 +consider: GO:0015036 + +[Term] +id: GO:0030509 +name: BMP signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor." [ISBN:0878932437] +synonym: "BMP receptor signaling pathway" RELATED [] +synonym: "BMP signalling pathway" EXACT [] +synonym: "bone morphogenetic protein signaling pathway" EXACT [] +synonym: "bone morphogenetic protein signalling pathway" EXACT [] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0030510 +name: regulation of BMP signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] +synonym: "regulation of BMP receptor signaling pathway" RELATED [] +synonym: "regulation of BMP signalling pathway" EXACT [] +synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT [] +synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0030511 +name: positive regulation of transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW [] +synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT [] +synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT [] +synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT [] +synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW [] +synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway +relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0030512 +name: negative regulation of transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] +synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW [] +synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT [] +synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT [] +synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT [] +xref: Reactome:173481 +xref: Reactome:173512 +xref: Reactome:209023 +xref: Reactome:211004 +xref: Reactome:218684 +xref: Reactome:220848 +xref: Reactome:235817 +xref: Reactome:237538 +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway +relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0030513 +name: positive regulation of BMP signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] +synonym: "activation of BMP signaling pathway" NARROW [] +synonym: "positive regulation of BMP receptor signaling pathway" RELATED [] +synonym: "positive regulation of BMP signalling pathway" EXACT [] +synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT [] +synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT [] +synonym: "stimulation of BMP signaling pathway" NARROW [] +synonym: "up regulation of BMP signaling pathway" EXACT [] +synonym: "up-regulation of BMP signaling pathway" EXACT [] +synonym: "upregulation of BMP signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0030510 ! regulation of BMP signaling pathway +relationship: positively_regulates GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0030514 +name: negative regulation of BMP signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] +synonym: "down regulation of BMP signaling pathway" EXACT [] +synonym: "down-regulation of BMP signaling pathway" EXACT [] +synonym: "downregulation of BMP signaling pathway" EXACT [] +synonym: "inhibition of BMP signaling pathway" NARROW [] +synonym: "negative regulation of BMP receptor signaling pathway" RELATED [] +synonym: "negative regulation of BMP signalling pathway" EXACT [] +synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT [] +synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0030510 ! regulation of BMP signaling pathway +relationship: negatively_regulates GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0030515 +name: snoRNA binding +namespace: molecular_function +def: "Interacting selectively with small nucleolar RNA." [GOC:mah] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0030516 +name: regulation of axon extension +namespace: biological_process +def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators] +is_a: GO:0050770 ! regulation of axonogenesis +relationship: regulates GO:0048675 ! axon extension + +[Term] +id: GO:0030517 +name: negative regulation of axon extension +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] +synonym: "down regulation of axon extension" EXACT [] +synonym: "down-regulation of axon extension" EXACT [] +synonym: "downregulation of axon extension" EXACT [] +synonym: "inhibition of axon extension" NARROW [] +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0050771 ! negative regulation of axonogenesis +relationship: negatively_regulates GO:0048675 ! axon extension + +[Term] +id: GO:0030518 +name: steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor." [GOC:mah] +synonym: "steroid hormone receptor signalling pathway" EXACT [] +is_a: GO:0030522 ! intracellular receptor-mediated signaling pathway + +[Term] +id: GO:0030519 +name: snoRNP binding +namespace: molecular_function +def: "Interacting selectively with a protein constituent of a small nucleolar ribonucleoprotein particle." [GOC:mah] +is_a: GO:0043021 ! ribonucleoprotein binding + +[Term] +id: GO:0030520 +name: estrogen receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GOC:mah] +synonym: "estrogen receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0030521 +name: androgen receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah] +synonym: "androgen receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0030522 +name: intracellular receptor-mediated signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by a ligand entering the target cell, where it binds to an intracellular receptor." [GOC:mah] +synonym: "intracellular receptor-mediated signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0030523 +name: dihydrolipoamide S-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah] +subset: gosubset_prok +is_a: GO:0016417 ! S-acyltransferase activity + +[Term] +id: GO:0030526 +name: granulocyte macrophage colony-stimulating factor receptor complex +namespace: cellular_component +def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0030527 +name: structural constituent of chromatin +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0030528 +name: transcription regulator activity +namespace: molecular_function +def: "Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "transcriptional regulator activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0030529 +name: ribonucleoprotein complex +namespace: cellular_component +def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] +subset: goslim_pir +subset: gosubset_prok +synonym: "protein-RNA complex" EXACT [] +synonym: "ribonucleoprotein" EXACT [] +synonym: "RNA-protein complex" EXACT [] +synonym: "RNP" EXACT [] +is_a: GO:0032991 ! macromolecular complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0030530 +name: heterogeneous nuclear ribonucleoprotein complex +namespace: cellular_component +def: "Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] +synonym: "hnRNP" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0030531 +name: small cytoplasmic ribonucleoprotein complex +namespace: cellular_component +def: "A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah] +synonym: "scRNP" EXACT [] +synonym: "small cytoplasmic ribonucleoprotein" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0030532 +name: small nuclear ribonucleoprotein complex +namespace: cellular_component +def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] +subset: goslim_pir +synonym: "small nuclear ribonucleoprotein" EXACT [] +synonym: "snRNP" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0030533 +name: triplet codon-amino acid adaptor activity +namespace: molecular_function +def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +synonym: "transfer RNA" RELATED [] +synonym: "tRNA" RELATED [] +is_a: GO:0000499 ! base pairing with mRNA +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0030534 +name: adult behavior +namespace: biological_process +def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] +comment: See also the biological process term 'behavior ; GO:0007610'. +synonym: "adult behavior (sensu Insecta)" NARROW [] +synonym: "adult behavioral response to stimulus" EXACT [] +synonym: "adult behaviour" EXACT [] +synonym: "adult behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0030535 +name: adult feeding behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jic] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +is_obsolete: true +replaced_by: GO:0008343 + +[Term] +id: GO:0030536 +name: larval feeding behavior +namespace: biological_process +def: "Feeding behavior in a larval (immature) organism." [GOC:mah] +comment: See also the biological process term 'feeding behavior ; GO:0007631'. +synonym: "larval feeding behavior (sensu Insecta)" NARROW [] +synonym: "larval feeding behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0030537 ! larval behavior + +[Term] +id: GO:0030537 +name: larval behavior +namespace: biological_process +alt_id: GO:0017037 +def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099] +comment: See also the biological process term 'behavior ; GO:0007610'. +synonym: "larval behavior (sensu Drosophila)" NARROW [] +synonym: "larval behavior (sensu Insecta)" NARROW [] +synonym: "larval behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0030538 +name: embryonic genitalia morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf] +synonym: "embryonic genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +is_a: GO:0048562 ! embryonic organ morphogenesis + +[Term] +id: GO:0030539 +name: male genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888] +synonym: "male genital development" EXACT [] +is_a: GO:0048806 ! genitalia development +relationship: part_of GO:0046546 ! development of primary male sexual characteristics + +[Term] +id: GO:0030540 +name: female genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah] +synonym: "female genital development" EXACT [] +is_a: GO:0048806 ! genitalia development +relationship: part_of GO:0046545 ! development of primary female sexual characteristics + +[Term] +id: GO:0030541 +name: plasmid partitioning +namespace: biological_process +alt_id: GO:0030542 +def: "Any process by which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah] +subset: gosubset_prok +synonym: "plasmid partitioning (sensu Bacteria)" NARROW [] +is_a: GO:0006276 ! plasmid maintenance + +[Term] +id: GO:0030543 +name: 2-micrometer plasmid partitioning +namespace: biological_process +def: "The process by which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah] +is_a: GO:0030541 ! plasmid partitioning + +[Term] +id: GO:0030544 +name: Hsp70 protein binding +namespace: molecular_function +def: "Interacting selectively with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0031072 ! heat shock protein binding + +[Term] +id: GO:0030545 +name: receptor regulator activity +namespace: molecular_function +def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb] +is_a: GO:0005057 ! receptor signaling protein activity + +[Term] +id: GO:0030546 +name: receptor activator activity +namespace: molecular_function +def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] +is_a: GO:0030545 ! receptor regulator activity + +[Term] +id: GO:0030547 +name: receptor inhibitor activity +namespace: molecular_function +def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb] +is_a: GO:0030545 ! receptor regulator activity + +[Term] +id: GO:0030548 +name: acetylcholine receptor regulator activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] +is_a: GO:0030545 ! receptor regulator activity + +[Term] +id: GO:0030549 +name: acetylcholine receptor activator activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] +is_a: GO:0030546 ! receptor activator activity +is_a: GO:0030548 ! acetylcholine receptor regulator activity + +[Term] +id: GO:0030550 +name: acetylcholine receptor inhibitor activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah] +is_a: GO:0030547 ! receptor inhibitor activity +is_a: GO:0030548 ! acetylcholine receptor regulator activity + +[Term] +id: GO:0030551 +name: cyclic nucleotide binding +namespace: molecular_function +def: "Interacting selectively with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai] +subset: gosubset_prok +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0030552 +name: cAMP binding +namespace: molecular_function +def: "Interacting selectively with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] +subset: gosubset_prok +synonym: "3',5' cAMP binding" EXACT [] +synonym: "3',5'-cAMP binding" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate binding" EXACT [] +synonym: "cyclic AMP binding" EXACT [] +is_a: GO:0016208 ! AMP binding +is_a: GO:0030551 ! cyclic nucleotide binding + +[Term] +id: GO:0030553 +name: cGMP binding +namespace: molecular_function +def: "Interacting selectively with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] +synonym: "3',5' cGMP binding" EXACT [] +synonym: "3',5'-cGMP binding" EXACT [] +synonym: "cyclic GMP binding" EXACT [] +is_a: GO:0019002 ! GMP binding +is_a: GO:0030551 ! cyclic nucleotide binding + +[Term] +id: GO:0030554 +name: adenyl nucleotide binding +namespace: molecular_function +def: "Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0017076 ! purine nucleotide binding + +[Term] +id: GO:0030555 +name: RNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +synonym: "small nucleolar RNA" RELATED [] +is_a: GO:0000498 ! base pairing with RNA + +[Term] +id: GO:0030556 +name: rRNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0000944 ! base pairing with rRNA +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030557 +name: tRNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0000946 ! base pairing with tRNA +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030558 +name: RNA pseudouridylation guide activity +namespace: molecular_function +def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030559 +name: rRNA pseudouridylation guide activity +namespace: molecular_function +def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0030556 ! rRNA modification guide activity +is_a: GO:0030558 ! RNA pseudouridylation guide activity + +[Term] +id: GO:0030560 +name: tRNA pseudouridylation guide activity +namespace: molecular_function +def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0030557 ! tRNA modification guide activity +is_a: GO:0030558 ! RNA pseudouridylation guide activity + +[Term] +id: GO:0030561 +name: RNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030562 +name: rRNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0030556 ! rRNA modification guide activity +is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity + +[Term] +id: GO:0030563 +name: snRNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745] +comment: Note that this term may be useful for annotating snoRNAs. +is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity +is_a: GO:0030566 ! snRNA modification guide activity + +[Term] +id: GO:0030564 +name: tRNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0030557 ! tRNA modification guide activity +is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity + +[Term] +id: GO:0030565 +name: snRNA pseudouridylation guide activity +namespace: molecular_function +def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745] +comment: Note that this term may be useful for annotating snoRNAs. +is_a: GO:0030558 ! RNA pseudouridylation guide activity +is_a: GO:0030566 ! snRNA modification guide activity + +[Term] +id: GO:0030566 +name: snRNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +is_a: GO:0000945 ! base pairing with snRNA +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030567 +name: prothrombin activator activity +namespace: molecular_function +def: "Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016504 ! protease activator activity + +[Term] +id: GO:0030568 +name: plasmin inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah] +is_a: GO:0004867 ! serine-type endopeptidase inhibitor activity + +[Term] +id: GO:0030569 +name: chymotrypsin inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah] +is_a: GO:0004867 ! serine-type endopeptidase inhibitor activity + +[Term] +id: GO:0030570 +name: pectate lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2] +subset: gosubset_prok +synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2] +synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] +synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] +synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2] +synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2] +synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2] +synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2] +synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2] +synonym: "pectic lyase activity" BROAD [EC:4.2.2.2] +synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2] +synonym: "PGA lyase activity" EXACT [EC:4.2.2.2] +synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2] +synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] +synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2] +synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2] +synonym: "PPase-N activity" EXACT [EC:4.2.2.2] +xref: EC:4.2.2.2 +xref: MetaCyc:4.2.2.2-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0030572 +name: phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) moiety." [GOC:mb] +subset: gosubset_prok +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0030573 +name: bile acid catabolic process +namespace: biological_process +alt_id: GO:0019613 +def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] +synonym: "bile acid breakdown" EXACT [] +synonym: "bile acid catabolism" EXACT [] +synonym: "bile acid degradation" EXACT [] +synonym: "cholate catabolic process" NARROW [] +xref: MetaCyc:7ALPHADEHYDROX-PWY +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0030574 +name: collagen catabolic process +namespace: biological_process +def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] +synonym: "collagen breakdown" EXACT [] +synonym: "collagen catabolism" EXACT [] +synonym: "collagen degradation" EXACT [] +is_a: GO:0032963 ! collagen metabolic process +is_a: GO:0044243 ! multicellular organismal catabolic process + +[Term] +id: GO:0030575 +name: nuclear body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah] +synonym: "nuclear body organisation and biogenesis" EXACT [] +synonym: "nuclear body organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0030576 +name: Cajal body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] +comment: See also the cellular component term 'Cajal body ; GO:0015030'. +synonym: "Cajal body organisation and biogenesis" EXACT [] +synonym: "Cajal body organization and biogenesis" EXACT [] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0030577 +name: Lands organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, UniProtKB:Q13342] +comment: See also the cellular component term 'Lands ; GO:0016606'. +synonym: "Lands organisation and biogenesis" EXACT [] +synonym: "Lands organization and biogenesis" EXACT [] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0030578 +name: PML body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078] +comment: See also the cellular component term 'PML body ; GO:0016605'. +synonym: "PML body organisation and biogenesis" EXACT [] +synonym: "PML body organization and biogenesis" EXACT [] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0030579 +name: ubiquitin-dependent SMAD protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators] +synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT [] +synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT [] +synonym: "ubiquitin-dependent SMAD protein degradation" EXACT [] +is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process +relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0030580 +name: quinone cofactor methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb] +subset: gosubset_prok +is_a: GO:0008169 ! C-methyltransferase activity + +[Term] +id: GO:0030581 +name: intracellular protein transport in host +namespace: biological_process +def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] +synonym: "host cell protein transport" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0051701 ! interaction with host +is_a: GO:0051708 ! intracellular protein transport in other organism during symbiotic interaction + +[Term] +id: GO:0030582 +name: fruiting body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores." [GOC:mah, GOC:mtg_sensu] +synonym: "fruiting body formation" EXACT [] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0030583 +name: fruiting body development in cellular response to starvation +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins when cells respond to a lack of nutrients in the environment and ends when the fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786] +comment: For example, as seen in myxobacterium and Dictyostelium. +subset: gosubset_prok +synonym: "fruiting body development (sensu Bacteria)" EXACT [] +synonym: "fruiting body formation (sensu Bacteria)" EXACT [] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0048869 ! cellular developmental process +is_a: GO:0055084 ! fruiting body development in response to starvation + +[Term] +id: GO:0030584 +name: sporocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ." [GOC:mah, GOC:mtg_sensu] +synonym: "fruiting body development (sensu Fungi)" EXACT [] +synonym: "fruiting body formation (sensu Fungi)" EXACT [] +is_a: GO:0030582 ! fruiting body development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0030585 +name: phosphoenolpyruvate carboxykinase (diphosphate) activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + oxaloacetate = phosphate + phosphoenolpyruvate + CO2." [EC:4.1.1.38] +synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38] +synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38] +synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] +synonym: "PEPCTrP" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] +synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38] +synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] +synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] +xref: EC:4.1.1.38 +xref: MetaCyc:4.1.1.38-RXN +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0030586 +name: [methionine synthase] reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] +comment: Note that this was EC:2.1.1.135. +synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED [] +synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT [] +synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8] +synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8] +synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8] +synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8] +xref: EC:1.16.1.8 +xref: MetaCyc:2.1.1.135-RXN +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0030587 +name: sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk." [DDB_REF:2530 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "fruiting body development (sensu Dictyosteliida)" EXACT [] +synonym: "fruiting body formation (sensu Dictyosteliida)" EXACT [] +synonym: "sorocarp biosynthesis" EXACT [] +synonym: "sorocarp formation" EXACT [] +is_a: GO:0055084 ! fruiting body development in response to starvation +relationship: part_of GO:0019954 ! asexual reproduction + +[Term] +id: GO:0030588 +name: pseudocleavage +namespace: biological_process +def: "Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:7729583] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0030589 +name: pseudocleavage during syncytial blastoderm formation +namespace: biological_process +def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos in the syncytial blastoderm stage." [GOC:mtg_sensu] +synonym: "pseudocleavage (sensu Insecta)" EXACT [] +is_a: GO:0030588 ! pseudocleavage +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0030590 +name: pseudocleavage during first cell cycle +namespace: biological_process +def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow." [GOC:mtg_sensu, PMID:7729583] +synonym: "pseudocleavage (sensu Nematoda)" EXACT [] +is_a: GO:0030588 ! pseudocleavage + +[Term] +id: GO:0030591 +name: NAD DNA ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the ADP-ribose moiety of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983] +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0030592 +name: DNA ADP-ribosylation +namespace: biological_process +def: "The covalent attachment of an ADP-ribosyl moiety to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA." [PMID:11592983] +subset: gosubset_prok +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0030593 +name: neutrophil chemotaxis +namespace: biological_process +def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0030594 +name: neurotransmitter receptor activity +namespace: molecular_function +def: "Combining with a neurotransmitter to initiate a change in cell activity." [GOC:jl] +is_a: GO:0004872 ! receptor activity +is_a: GO:0042165 ! neurotransmitter binding + +[Term] +id: GO:0030595 +name: leukocyte chemotaxis +namespace: biological_process +def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] +synonym: "immune cell chemotaxis" EXACT [] +synonym: "leucocyte chemotaxis" EXACT [] +is_a: GO:0050900 ! leukocyte migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0030596 +name: alpha-L-rhamnosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40] +subset: gosubset_prok +synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40] +synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40] +synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40] +xref: EC:3.2.1.40 +xref: MetaCyc:3.2.1.40-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0030597 +name: RNA glycosylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0030598 +name: rRNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah] +subset: gosubset_prok +synonym: "gelonin" RELATED [EC:3.2.2.22] +synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22] +synonym: "momorcochin-S" RELATED [EC:3.2.2.22] +synonym: "nigrin b" RELATED [EC:3.2.2.22] +synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22] +synonym: "ricin" RELATED [EC:3.2.2.22] +synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22] +synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22] +synonym: "rRNA N-glycosidase activity" EXACT [] +synonym: "saporins" RELATED [EC:3.2.2.22] +xref: EC:3.2.2.22 +xref: MetaCyc:3.2.2.22-RXN +is_a: GO:0030597 ! RNA glycosylase activity + +[Term] +id: GO:0030599 +name: pectinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11] +subset: gosubset_prok +synonym: "pectase activity" EXACT [EC:3.1.1.11] +synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11] +synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11] +synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11] +synonym: "pectin methylesterase activity" EXACT [] +synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11] +synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11] +xref: EC:3.1.1.11 +xref: MetaCyc:PECTINESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0030600 +name: feruloyl esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73] +synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73] +synonym: "cinnAE" RELATED [EC:3.1.1.73] +synonym: "cinnamoyl ester hydrolase activity" EXACT [] +synonym: "FAE-I" RELATED [EC:3.1.1.73] +synonym: "FAE-II" RELATED [EC:3.1.1.73] +synonym: "FAE-III" RELATED [EC:3.1.1.73] +synonym: "FAEA" RELATED [EC:3.1.1.73] +synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73] +synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73] +synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73] +xref: EC:3.1.1.73 +xref: MetaCyc:3.1.1.73-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0030601 +name: aminopeptidase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6] +comment: This term was made obsolete because it represents a gene product. +synonym: "arginyl aminopeptidase activity" EXACT [] +synonym: "arylamidase II" RELATED [EC:3.4.11.6] +synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6] +synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] +synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6] +xref: EC:3.4.11.6 +xref: MetaCyc:3.4.11.6-RXN +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0030602 +name: chymosin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4] +comment: This term was made obsolete because it represents a gene product. +synonym: "rennin" RELATED [EC:3.4.23.4] +synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] +xref: EC:3.4.23.4 +xref: MetaCyc:3.4.23.4-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0030603 +name: oxaloacetase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetate + H2O = oxalate + acetate." [EC:3.7.1.1] +synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1] +synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1] +xref: EC:3.7.1.1 +xref: MetaCyc:OXALOACETASE-RXN +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0030604 +name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis." [EC:1.1.1.267, GOC:mb] +subset: gosubset_prok +synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267] +synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267] +synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267] +synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267] +synonym: "DOXP reductoisomerase activity" EXACT [] +synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267] +xref: EC:1.1.1.267 +xref: MetaCyc:DXPREDISOM-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030611 +name: arsenate reductase activity +namespace: molecular_function +def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0030612 +name: arsenate reductase (thioredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is NADPH -> thioredoxin reductase -> thioredoxin -> arsenate reductase." [GOC:kd] +is_a: GO:0030611 ! arsenate reductase activity + +[Term] +id: GO:0030613 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] +comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW [] +xref: EC:1.20 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0030614 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT [] +xref: EC:1.20.4 +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0030616 +name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity +namespace: molecular_function +def: "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] +comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family. +synonym: "common-partner SMAD protein" RELATED [] +synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT [] +is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity + +[Term] +id: GO:0030617 +name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity +namespace: molecular_function +def: "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503] +comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family. +synonym: "inhibitory SMAD protein" RELATED [] +synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT [] +is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity + +[Term] +id: GO:0030618 +name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity +namespace: molecular_function +def: "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] +comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family. +synonym: "pathway-specific SMAD protein" NARROW [] +synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] +is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity + +[Term] +id: GO:0030619 +name: U1 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah] +comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030620 +name: U2 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030621 +name: U4 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030622 +name: U4atac snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030623 +name: U5 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030624 +name: U6atac snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030625 +name: U11 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030626 +name: U12 snRNA binding +namespace: molecular_function +def: "Interacting selectively with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030627 +name: pre-mRNA 5'-splice site binding +namespace: molecular_function +def: "Interacting selectively with the pre-mRNA 5' splice site sequence." [GOC:jl] +synonym: "pre-mRNA 5' splice site binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0030628 +name: pre-mRNA 3'-splice site binding +namespace: molecular_function +def: "Interacting selectively with the pre-mRNA 3' splice site sequence." [GOC:jl] +synonym: "pre-mRNA 3' splice site binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0030629 +name: U6 snRNA 3'-end binding +namespace: molecular_function +def: "Interacting selectively with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] +comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). +synonym: "U6 snRNA 3' end binding" EXACT [] +is_a: GO:0017070 ! U6 snRNA binding + +[Term] +id: GO:0030631 +name: lysine methylamine methyltransferase cofactor adduct incorporation +namespace: biological_process +def: "The incorporation of a lysine methylamine methyltransferase cofactor adduct into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. The lysine methylamine methyltransferase cofactor adduct is synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, RESID:AA0321] +subset: gosubset_prok +xref: RESID:AA0321 +is_a: GO:0006451 ! translational readthrough + +[Term] +id: GO:0030632 +name: D-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-alanine, the dextrorotatory isomer of the amino acid alanine." [GOC:mah] +subset: gosubset_prok +synonym: "D-alanine anabolism" EXACT [] +synonym: "D-alanine biosynthesis" EXACT [] +synonym: "D-alanine formation" EXACT [] +synonym: "D-alanine synthesis" EXACT [] +is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process +is_a: GO:0046436 ! D-alanine metabolic process +is_a: GO:0046437 ! D-amino acid biosynthetic process + +[Term] +id: GO:0030633 +name: D-alanine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah] +subset: gosubset_prok +synonym: "D-alanine family amino acid breakdown" EXACT [] +synonym: "D-alanine family amino acid catabolism" EXACT [] +synonym: "D-alanine family amino acid degradation" EXACT [] +is_a: GO:0006524 ! alanine catabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process + +[Term] +id: GO:0030634 +name: carbon fixation by acetyl-CoA pathway +namespace: biological_process +def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093] +subset: gosubset_prok +synonym: "Ljungdahl-Wood pathway" EXACT [] +is_a: GO:0006085 ! acetyl-CoA biosynthetic process +is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide + +[Term] +id: GO:0030635 +name: acetate derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah] +subset: gosubset_prok +synonym: "acetate derivative metabolism" EXACT [] +is_a: GO:0006083 ! acetate metabolic process + +[Term] +id: GO:0030636 +name: acetate derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah] +subset: gosubset_prok +synonym: "acetate derivative anabolism" EXACT [] +synonym: "acetate derivative biosynthesis" EXACT [] +synonym: "acetate derivative formation" EXACT [] +synonym: "acetate derivative synthesis" EXACT [] +is_a: GO:0019413 ! acetate biosynthetic process +is_a: GO:0030635 ! acetate derivative metabolic process + +[Term] +id: GO:0030637 +name: acetate derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai] +subset: gosubset_prok +synonym: "acetate derivative breakdown" EXACT [] +synonym: "acetate derivative catabolism" EXACT [] +synonym: "acetate derivative degradation" EXACT [] +is_a: GO:0030635 ! acetate derivative metabolic process +is_a: GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0030638 +name: polyketide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyketide metabolism" EXACT [] +is_a: GO:0030635 ! acetate derivative metabolic process + +[Term] +id: GO:0030639 +name: polyketide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyketide anabolism" EXACT [] +synonym: "polyketide biosynthesis" EXACT [] +synonym: "polyketide formation" EXACT [] +synonym: "polyketide synthesis" EXACT [] +is_a: GO:0030636 ! acetate derivative biosynthetic process +is_a: GO:0030638 ! polyketide metabolic process + +[Term] +id: GO:0030640 +name: polyketide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "polyketide breakdown" EXACT [] +synonym: "polyketide catabolism" EXACT [] +synonym: "polyketide degradation" EXACT [] +is_a: GO:0030637 ! acetate derivative catabolic process +is_a: GO:0030638 ! polyketide metabolic process + +[Term] +id: GO:0030641 +name: regulation of cellular pH +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] +subset: gosubset_prok +synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] +synonym: "proton homeostasis" EXACT [] +is_a: GO:0006885 ! regulation of pH +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis + +[Term] +id: GO:0030642 +name: cellular sulfate ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of sulfate ions within a cell or between a cell and its external environment." [GOC:mah] +synonym: "sulphate ion homeostasis" BROAD [] +is_a: GO:0030319 ! cellular di-, tri-valent inorganic anion homeostasis +is_a: GO:0055063 ! sulfate ion homeostasis + +[Term] +id: GO:0030643 +name: cellular phosphate ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of phosphate ions within a cell or between a cell and its external environment." [GOC:mah] +is_a: GO:0030319 ! cellular di-, tri-valent inorganic anion homeostasis +is_a: GO:0055062 ! phosphate ion homeostasis + +[Term] +id: GO:0030644 +name: cellular chloride ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of chloride ions within a cell or between a cell and its external environment." [GOC:mah] +is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis +is_a: GO:0055064 ! chloride ion homeostasis + +[Term] +id: GO:0030645 +name: glucose catabolic process to butyrate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "butyrate fermentation" EXACT [] +synonym: "glucose fermentation to butyrate" EXACT [] +is_a: GO:0006113 ! fermentation +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:0030647 +name: aminoglycoside antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminoglycoside antibiotic metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0016999 ! antibiotic metabolic process + +[Term] +id: GO:0030648 +name: aminoglycoside antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminoglycoside antibiotic anabolism" EXACT [] +synonym: "aminoglycoside antibiotic biosynthesis" EXACT [] +synonym: "aminoglycoside antibiotic formation" EXACT [] +synonym: "aminoglycoside antibiotic synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:0030649 +name: aminoglycoside antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aminoglycoside antibiotic breakdown" EXACT [] +synonym: "aminoglycoside antibiotic catabolism" EXACT [] +synonym: "aminoglycoside antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:0030650 +name: peptide antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah] +subset: gosubset_prok +synonym: "peptide antibiotic metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0016999 ! antibiotic metabolic process + +[Term] +id: GO:0030651 +name: peptide antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah] +subset: gosubset_prok +synonym: "peptide antibiotic anabolism" EXACT [] +synonym: "peptide antibiotic biosynthesis" EXACT [] +synonym: "peptide antibiotic formation" EXACT [] +synonym: "peptide antibiotic synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030650 ! peptide antibiotic metabolic process +is_a: GO:0043043 ! peptide biosynthetic process + +[Term] +id: GO:0030652 +name: peptide antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah] +subset: gosubset_prok +synonym: "peptide antibiotic breakdown" EXACT [] +synonym: "peptide antibiotic catabolism" EXACT [] +synonym: "peptide antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0030650 ! peptide antibiotic metabolic process +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0030653 +name: beta-lactam antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-lactam antibiotic metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0030654 +name: beta-lactam antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-lactam antibiotic anabolism" EXACT [] +synonym: "beta-lactam antibiotic biosynthesis" EXACT [] +synonym: "beta-lactam antibiotic formation" EXACT [] +synonym: "beta-lactam antibiotic synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process + +[Term] +id: GO:0030655 +name: beta-lactam antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "beta-lactam antibiotic breakdown" EXACT [] +synonym: "beta-lactam antibiotic catabolism" EXACT [] +synonym: "beta-lactam antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process + +[Term] +id: GO:0030656 +name: regulation of vitamin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of vitamin metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0030657 +name: regulation of coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +is_obsolete: true +consider: GO:0051196 +consider: GO:0051199 + +[Term] +id: GO:0030658 +name: transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] +synonym: "secretory vesicle membrane" BROAD [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0030133 ! transport vesicle + +[Term] +id: GO:0030659 +name: cytoplasmic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] +subset: gosubset_prok +is_a: GO:0012506 ! vesicle membrane +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0030660 +name: Golgi-associated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] +synonym: "Golgi vesicle membrane" RELATED [] +is_a: GO:0000139 ! Golgi membrane +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0005798 ! Golgi-associated vesicle + +[Term] +id: GO:0030661 +name: chitosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a chitosome." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0045009 ! chitosome + +[Term] +id: GO:0030662 +name: coated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0030135 ! coated vesicle + +[Term] +id: GO:0030663 +name: COPI coated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] +is_a: GO:0030660 ! Golgi-associated vesicle membrane +is_a: GO:0030662 ! coated vesicle membrane +relationship: part_of GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0030665 +name: clathrin coated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] +is_a: GO:0030662 ! coated vesicle membrane +relationship: part_of GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0030666 +name: endocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0030667 +name: secretory granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] +synonym: "secretory vesicle membrane" BROAD [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0030141 ! secretory granule + +[Term] +id: GO:0030668 +name: merozoite dense granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu] +synonym: "dense granule membrane (sensu Apicomplexa)" EXACT [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0020026 ! merozoite dense granule + +[Term] +id: GO:0030669 +name: clathrin-coated endocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah] +is_a: GO:0030665 ! clathrin coated vesicle membrane +is_a: GO:0030666 ! endocytic vesicle membrane +relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle + +[Term] +id: GO:0030670 +name: phagocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah] +is_a: GO:0030666 ! endocytic vesicle membrane +relationship: part_of GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0030671 +name: clathrin-coated phagocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah] +is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane +is_a: GO:0030670 ! phagocytic vesicle membrane +relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle + +[Term] +id: GO:0030672 +name: synaptic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah] +is_a: GO:0030665 ! clathrin coated vesicle membrane +relationship: part_of GO:0008021 ! synaptic vesicle + +[Term] +id: GO:0030673 +name: axolemma +namespace: cellular_component +def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] +is_a: GO:0016020 ! membrane +is_a: GO:0032589 ! neuron projection membrane +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0030674 +name: protein binding, bridging +namespace: molecular_function +def: "Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other." [GOC:mah] +subset: gosubset_prok +synonym: "protein-protein adaptor" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030675 +name: Rac GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Rac family." [GOC:mah] +is_a: GO:0005100 ! Rho GTPase activator activity + +[Term] +id: GO:0030676 +name: Rac guanyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Stimulates the exchange of guanyl nucleotides by a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] +is_a: GO:0005089 ! Rho guanyl-nucleotide exchange factor activity + +[Term] +id: GO:0030677 +name: ribonuclease P complex +namespace: cellular_component +def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] +comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. +subset: goslim_pir +subset: gosubset_prok +synonym: "RNase P complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0030678 +name: mitochondrial ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094] +synonym: "mitochondrial RNase P complex" EXACT [] +is_a: GO:0030677 ! ribonuclease P complex +is_a: GO:0044429 ! mitochondrial part + +[Term] +id: GO:0030679 +name: cyanelle ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] +synonym: "cyanelle RNase P complex" EXACT [] +is_a: GO:0030681 ! multimeric ribonuclease P complex +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0030680 +name: dimeric ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule." [GOC:mah, PMID:12045094] +subset: gosubset_prok +synonym: "dimeric RNase P complex" EXACT [] +synonym: "ribonuclease P complex (sensu Bacteria)" NARROW [] +synonym: "RNase P complex (sensu Bacteria)" NARROW [] +is_a: GO:0030677 ! ribonuclease P complex + +[Term] +id: GO:0030681 +name: multimeric ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules." [GOC:mah, PMID:11142368, PMID:12045094] +synonym: "multimeric RNase P complex" EXACT [] +synonym: "ribonuclease P complex (sensu Archaea" NARROW [] +synonym: "RNase P complex (sensu Archaea)" NARROW [] +is_a: GO:0030677 ! ribonuclease P complex + +[Term] +id: GO:0030682 +name: evasion or tolerance of host defense response +namespace: biological_process +def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "evasion of host defence response" EXACT [] +is_a: GO:0044415 ! evasion or tolerance of host defenses +is_a: GO:0051807 ! evasion or tolerance of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0030683 +name: evasion by virus of host immune response +namespace: biological_process +def: "Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] +xref: Reactome:168305 +xref: Reactome:168888 +xref: Reactome:168891 +xref: Reactome:168896 +xref: Reactome:169131 +is_a: GO:0019049 ! evasion of host defenses by virus +is_a: GO:0020012 ! evasion or tolerance of host immune response + +[Term] +id: GO:0030684 +name: preribosome +namespace: cellular_component +def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] +subset: goslim_pir +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0030685 +name: nucleolar preribosome +namespace: cellular_component +def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516] +is_a: GO:0030684 ! preribosome +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0030686 +name: 90S preribosome +namespace: cellular_component +def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12150911, PMID:12957375, PMID:15120992] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0030687 +name: preribosome, large subunit precursor +namespace: cellular_component +def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516] +comment: Note that this complex is 66S in Saccharomyces. +synonym: "66S preribosome" NARROW [] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0030688 +name: preribosome, small subunit precursor +namespace: cellular_component +def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516] +comment: Note that this complex is 43S in Saccharomyces. +synonym: "43S preribosome" NARROW [] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0030689 +name: Noc complex +namespace: cellular_component +def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671] +comment: Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0030690 +name: Noc1p-Noc2p complex +namespace: cellular_component +def: "A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0030689 ! Noc complex +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030686 ! 90S preribosome +relationship: part_of GO:0030687 ! preribosome, large subunit precursor + +[Term] +id: GO:0030691 +name: Noc2p-Noc3p complex +namespace: cellular_component +def: "A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis." [PMID:12446671] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0030689 ! Noc complex +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044451 ! nucleoplasm part +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030687 ! preribosome, large subunit precursor + +[Term] +id: GO:0030692 +name: Noc4p-Nop14p complex +namespace: cellular_component +def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0030689 ! Noc complex +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030686 ! 90S preribosome +relationship: part_of GO:0030688 ! preribosome, small subunit precursor + +[Term] +id: GO:0030693 +name: caspase activity +namespace: molecular_function +alt_id: GO:0004199 +def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-1 activity" NARROW [] +synonym: "caspase-10 activity" NARROW [] +synonym: "caspase-2 activity" NARROW [] +synonym: "caspase-3 activity" NARROW [] +synonym: "caspase-4 activity" NARROW [] +synonym: "caspase-5 activity" NARROW [] +synonym: "caspase-6 activity" NARROW [] +synonym: "caspase-7 activity" NARROW [] +synonym: "caspase-8 activity" NARROW [] +synonym: "caspase-9 activity" NARROW [] +synonym: "effector caspase activity" NARROW [] +synonym: "signaling (initiator) caspase activity" NARROW [] +xref: Reactome:82077 +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0030694 +name: flagellin-based flagellum basal body, rod +namespace: cellular_component +def: "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] +subset: gosubset_prok +synonym: "flagellar basal body, rod" EXACT [] +synonym: "flagellar basal body, rod (sensu Bacteria)" EXACT [] +is_a: GO:0044461 ! flagellin-based flagellum part +relationship: part_of GO:0009425 ! flagellin-based flagellum basal body + +[Term] +id: GO:0030695 +name: GTPase regulator activity +namespace: molecular_function +def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0030696 +name: tRNA (m5U54) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] +comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. +synonym: "RUMT" EXACT [] +is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity + +[Term] +id: GO:0030697 +name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] +synonym: "RUMT" BROAD [] +synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT [] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity + +[Term] +id: GO:0030698 +name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"] +synonym: "RUMT" BROAD [] +is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity +is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0030699 +name: glycine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + ammonia + thioredoxin disulfide = glycine + phosphate + thioredoxin." [EC:1.21.4.2] +subset: gosubset_prok +synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2] +xref: EC:1.21.4.2 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0030700 +name: glycine reductase complex +namespace: cellular_component +def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0030701 +name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37] +subset: gosubset_prok +synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37] +synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37] +synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37] +synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37] +synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] +xref: EC:2.4.2.37 +xref: MetaCyc:2.4.2.37-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0030702 +name: chromatin silencing at centromere +namespace: biological_process +def: "Repression of transcription of centromeric DNA by the formation of heterochromatin." [GOC:mah] +synonym: "heterochromatic silencing at centromere" EXACT [] +is_a: GO:0006342 ! chromatin silencing +is_a: GO:0031508 ! centromeric heterochromatin formation + +[Term] +id: GO:0030703 +name: eggshell formation +namespace: biological_process +def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030704 +name: vitelline membrane formation +namespace: biological_process +def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238] +is_a: GO:0030198 ! extracellular matrix organization +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030705 +name: cytoskeleton-dependent intracellular transport +namespace: biological_process +def: "The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell." [GOC:mah] +subset: gosubset_prok +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0030706 +name: germarium-derived oocyte differentiation +namespace: biological_process +def: "The process whereby one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte cell differentiation (sensu Insecta)" EXACT [] +synonym: "oocyte differentiation (sensu Insecta)" EXACT [] +is_a: GO:0009994 ! oocyte differentiation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030707 +name: ovarian follicle cell development +namespace: biological_process +def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary." [GOC:mtg_sensu, PMID:10822261] +synonym: "ovarian follicle cell development (sensu Insecta)" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030708 +name: germarium-derived female germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium." [GOC:mtg_sensu, PMID:11591336] +synonym: "female germ-line cyst encapsulation (sensu Insecta)" EXACT [] +is_a: GO:0048139 ! female germ-line cyst encapsulation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030709 +name: border follicle cell delamination +namespace: biological_process +def: "The splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] +synonym: "border cell delamination" BROAD [] +is_a: GO:0060232 ! delamination +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030710 +name: regulation of border follicle cell delamination +namespace: biological_process +def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261] +synonym: "regulation of border cell delamination" BROAD [] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0030709 ! border follicle cell delamination + +[Term] +id: GO:0030711 +name: positive regulation of border follicle cell delamination +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261] +synonym: "activation of border follicle cell delamination" NARROW [] +synonym: "positive regulation of border cell delamination" BROAD [] +synonym: "stimulation of border follicle cell delamination" NARROW [] +synonym: "up regulation of border follicle cell delamination" EXACT [] +synonym: "up-regulation of border follicle cell delamination" EXACT [] +synonym: "upregulation of border follicle cell delamination" EXACT [] +is_a: GO:0030710 ! regulation of border follicle cell delamination +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0030709 ! border follicle cell delamination + +[Term] +id: GO:0030712 +name: negative regulation of border follicle cell delamination +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261] +synonym: "down regulation of border follicle cell delamination" EXACT [] +synonym: "down-regulation of border follicle cell delamination" EXACT [] +synonym: "downregulation of border follicle cell delamination" EXACT [] +synonym: "inhibition of border follicle cell delamination" NARROW [] +synonym: "negative regulation of border cell delamination" BROAD [] +is_a: GO:0030710 ! regulation of border follicle cell delamination +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0030709 ! border follicle cell delamination + +[Term] +id: GO:0030713 +name: ovarian follicle cell stalk formation +namespace: biological_process +def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages." [GOC:mtg_sensu, PMID:10822261] +synonym: "stalk formation (sensu Insecta)" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030714 +name: anterior/posterior axis specification, follicular epithelium +namespace: biological_process +def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] +synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009952 ! anterior/posterior pattern formation +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030715 +name: oocyte growth in germarium-derived egg chamber +namespace: biological_process +def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte growth (sensu Insecta)" EXACT [] +is_a: GO:0001555 ! oocyte growth +relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber + +[Term] +id: GO:0030716 +name: oocyte fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "oocyte cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination + +[Term] +id: GO:0030717 +name: karyosome formation +namespace: biological_process +def: "Condensation of DNA in the oocyte nucleus into a compact spherical structure called the karyosome." [PMID:11700288] +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030718 +name: germ-line stem cell maintenance +namespace: biological_process +def: "Any process involved in preventing uncommitted germ-line stem cells from differentiating as another cell type." [ISBN:0879694238] +is_a: GO:0019827 ! stem cell maintenance + +[Term] +id: GO:0030719 +name: P granule organization +namespace: biological_process +alt_id: GO:0048114 +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] +synonym: "P granule organization and biogenesis" RELATED [] +synonym: "polar granule organisation and biogenesis" EXACT [] +synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0007315 ! pole plasm assembly + +[Term] +id: GO:0030720 +name: oocyte localization during germarium-derived egg chamber formation +namespace: biological_process +def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] +synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] +synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] +synonym: "oocyte localization during oogenesis" RELATED [] +synonym: "oocyte positioning during oogenesis" NARROW [] +synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] +synonym: "oogenesis, oocyte localization" EXACT [] +is_a: GO:0051674 ! localization of cell +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030721 +name: spectrosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] +synonym: "spectrosome organisation and biogenesis" EXACT [] +synonym: "spectrosome organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0030722 +name: establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0048126 +def: "The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] +synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" EXACT [] +synonym: "establishment of localization of oocyte nucleus during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "establishment of oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb] +synonym: "establishment of oocyte nucleus localization during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "nucleus positioning in oocyte during oocyte axis determination" EXACT [] +synonym: "nucleus positioning in oocyte during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, establishment of localization of nucleus" EXACT [] +synonym: "oocyte axis determination, establishment of localization of nucleus (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, establishment of oocyte nucleus localization" EXACT [] +synonym: "oocyte axis determination, establishment of oocyte nucleus localization (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, establishment of position of nucleus" EXACT [] +synonym: "oocyte axis determination, establishment of position of nucleus (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, positioning of nucleus" EXACT [] +synonym: "oocyte axis determination, positioning of nucleus (sensu Insecta)" EXACT [] +synonym: "oocyte nucleus positioning during oocyte axis determination" EXACT [] +synonym: "oocyte nucleus positioning during oocyte axis determination (sensu Insecta)" EXACT [] +is_a: GO:0040023 ! establishment of nucleus localization +relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification + +[Term] +id: GO:0030723 +name: ovarian fusome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] +synonym: "ovarian fusome organisation and biogenesis" EXACT [] +synonym: "ovarian fusome organization and biogenesis" EXACT [] +is_a: GO:0045478 ! fusome organization +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030724 +name: testicular fusome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] +synonym: "testicular fusome organisation and biogenesis" EXACT [] +synonym: "testicular fusome organization and biogenesis" EXACT [] +is_a: GO:0045478 ! fusome organization +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0030725 +name: ring canal formation +namespace: biological_process +def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] +is_a: GO:0043063 ! intercellular bridge organization + +[Term] +id: GO:0030726 +name: testicular ring canal formation +namespace: biological_process +def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238] +is_a: GO:0030725 ! ring canal formation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0030727 +name: germarium-derived female germ-line cyst formation +namespace: biological_process +def: "Formation of a cluster of germ-line cells, in the germarium, derived from a single founder cell (cystoblast)." [GOC:mtg_sensu, PMID:10370240] +synonym: "female germ-line cyst formation (sensu Insecta)" EXACT [] +is_a: GO:0048135 ! female germ-line cyst formation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030728 +name: ovulation +namespace: biological_process +def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0030729 +name: acetoacetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA." [EC:6.2.1.16] +subset: gosubset_prok +synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16] +synonym: "acetoacetyl-CoA synthetase activity" EXACT [] +xref: EC:6.2.1.16 +xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0030730 +name: sequestering of triacylglycerol +namespace: biological_process +def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "retention of triacylglycerol" EXACT [] +synonym: "retention of triglyceride" EXACT [] +synonym: "sequestering of triglyceride" EXACT [] +synonym: "sequestration of triacylglycerol" EXACT [] +synonym: "sequestration of triglyceride" EXACT [] +synonym: "storage of triacylglycerol" EXACT [] +synonym: "storage of triglyceride" EXACT [] +synonym: "triacylglycerol retention" EXACT [] +synonym: "triacylglycerol sequestering" EXACT [] +synonym: "triacylglycerol sequestration" EXACT [] +synonym: "triacylglycerol storage" EXACT [] +synonym: "triglyceride retention" EXACT [] +synonym: "triglyceride sequestering" EXACT [] +synonym: "triglyceride sequestration" EXACT [] +synonym: "triglyceride storage" EXACT [] +is_a: GO:0019915 ! sequestering of lipid +is_a: GO:0051235 ! maintenance of location + +[Term] +id: GO:0030731 +name: guanidinoacetate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine." [EC:2.1.1.2] +synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2] +synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] +synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2] +synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2] +synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2] +synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] +xref: EC:2.1.1.2 +xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030732 +name: methionine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12] +synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12] +synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12] +synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12] +synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12] +synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12] +xref: EC:2.1.1.12 +xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030733 +name: fatty-acid O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15] +synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15] +synonym: "fatty acid O-methyltransferase activity" EXACT [EC:2.1.1.15] +synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15] +xref: EC:2.1.1.15 +xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030734 +name: polysaccharide O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18] +synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18] +synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18] +synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18] +xref: EC:2.1.1.18 +xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030735 +name: carnosine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine." [EC:2.1.1.22] +synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22] +xref: EC:2.1.1.22 +xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030736 +name: phenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole." [EC:2.1.1.25] +synonym: "PMT" RELATED [EC:2.1.1.25] +synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25] +xref: EC:2.1.1.25 +xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030737 +name: iodophenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether." [EC:2.1.1.26] +synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26] +xref: EC:2.1.1.26 +xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030738 +name: tyramine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = S-adenosyl-L-homocysteine + N-methyltyramine." [EC:2.1.1.27] +synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27] +synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] +synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] +synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27] +xref: EC:2.1.1.27 +xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030739 +name: O-demethylpuromycin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38] +subset: gosubset_prok +synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38] +synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38] +xref: EC:2.1.1.38 +xref: MetaCyc:2.1.1.38-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030740 +name: inositol 3-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-3-O-methyl-myo-inositol." [EC:2.1.1.39] +synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39] +synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39] +synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39] +synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39] +synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39] +xref: EC:2.1.1.39 +xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030741 +name: inositol 1-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol." [EC:2.1.1.40] +synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40] +synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40] +synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40] +synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40] +synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40] +xref: EC:2.1.1.40 +xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030742 +name: GTP-dependent protein binding +namespace: molecular_function +def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP." [GOC:go_curators] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030743 +name: rRNA (adenosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66] +subset: gosubset_prok +synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.66] +synonym: "RNA-pentose methylase activity" RELATED [EC:2.1.1.66] +synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.66] +synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.66] +synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.66] +xref: EC:2.1.1.66 +xref: MetaCyc:2.1.1.66-RXN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0030744 +name: luteolin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxyflavone = S-adenosyl-L-homocysteine + 5,7,4'-trihydroxy-3'-methoxyflavone." [EC:2.1.1.42] +synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] +synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42] +synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42] +synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42] +synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42] +synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] +synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] +xref: EC:2.1.1.42 +xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030745 +name: dimethylhistidine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + NN1,NN1-dimethyl-L-histidine = S-adenosyl-L-homocysteine + NN1,NN1,NN1-trimethyl-L-histidine." [EC:2.1.1.44] +synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44] +synonym: "histidine-alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44] +xref: EC:2.1.1.44 +xref: MetaCyc:2.1.1.44-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030746 +name: isoflavone 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46] +synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46] +synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46] +synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46] +synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46] +xref: EC:2.1.1.46 +xref: MetaCyc:ISOFLAVONE-4'-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030747 +name: indolepyruvate C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47] +synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47] +synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47] +synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47] +synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] +synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] +xref: EC:2.1.1.47 +xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030748 +name: amine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49] +synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49] +synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49] +synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49] +synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49] +synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49] +xref: EC:2.1.1.49 +xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030749 +name: loganate O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50] +synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50] +synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50] +synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50] +xref: EC:2.1.1.50 +xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030750 +name: putrescine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine." [EC:2.1.1.53] +synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53] +synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53] +xref: EC:2.1.1.53 +xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030751 +name: licodione 2'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O-methyllicodione." [EC:2.1.1.65] +synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65] +xref: EC:2.1.1.65 +xref: MetaCyc:LICODIONE-2'-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030752 +name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0030764 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69] +synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "BMT activity" EXACT [EC:2.1.1.69] +synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69] +xref: EC:2.1.1.69 +xref: MetaCyc:2.1.1.69-RXN +xref: MetaCyc:BERGAPTOL-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030753 +name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 8-methoxyfuranocoumarin." [EC:2.1.1.70] +synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70] +synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70] +synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] +synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] +synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] +synonym: "XMT activity" RELATED [EC:2.1.1.70] +xref: EC:2.1.1.70 +xref: MetaCyc:2.1.1.70-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030754 +name: apigenin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75] +synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75] +synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75] +synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75] +xref: EC:2.1.1.75 +xref: MetaCyc:APIGENIN-4'-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030755 +name: quercetin 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76] +synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76] +synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] +synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76] +xref: EC:2.1.1.76 +xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030756 +name: isoorientin 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoorientin = S-adenosyl-L-homocysteine + isoscoparin." [EC:2.1.1.78] +synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78] +synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78] +xref: EC:2.1.1.78 +xref: MetaCyc:ISOORIENTIN-3'-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030757 +name: 3-methylquercitin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxy-3-methoxyflavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,7-dimethoxy-flavone." [EC:2.1.1.82] +synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] +synonym: "7-OMT activity" RELATED [EC:2.1.1.82] +synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82] +synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] +synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] +synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] +xref: EC:2.1.1.82 +xref: MetaCyc:2.1.1.82-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030758 +name: 3,7-dimethylquercitin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 3',5-dihydroxy-3,4',7-trimethoxy-flavone." [EC:2.1.1.83] +synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] +synonym: "4'-OMT activity" RELATED [EC:2.1.1.83] +synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83] +synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] +synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] +synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] +xref: EC:2.1.1.83 +xref: MetaCyc:2.1.1.83-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030759 +name: methylquercetagetin 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,6-tetrahydroxy-3,7-dimethoxy-flavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,6,7-trimethoxyflavone." [EC:2.1.1.84] +synonym: "6-OMT" RELATED [EC:2.1.1.84] +synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84] +synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] +synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84] +xref: EC:2.1.1.84 +xref: MetaCyc:2.1.1.84-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030760 +name: pyridine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium." [EC:2.1.1.87] +synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87] +synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87] +xref: EC:2.1.1.87 +xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030761 +name: 8-hydroxyquercitin 8-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxy-flavone." [EC:2.1.1.88] +synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] +synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88] +synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] +synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] +xref: EC:2.1.1.88 +xref: MetaCyc:2.1.1.88-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030762 +name: tetrahydrocolumbamine 2-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine." [EC:2.1.1.89] +synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89] +synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89] +xref: EC:2.1.1.89 +xref: MetaCyc:2.1.1.89-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030763 +name: isobutyraldoxime O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methylpropanal oxime = S-adenosyl-L-homocysteine + 2-methylpropanal O-methyloxime." [EC:2.1.1.91] +synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91] +synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] +synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91] +synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] +xref: EC:2.1.1.91 +xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030765 +name: xanthotoxol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + O-methylxanthotoxol." [EC:2.1.1.93] +synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.93] +synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.93] +xref: EC:2.1.1.93 +xref: MetaCyc:XANTHOTOXOL-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030766 +name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94] +synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94] +synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94] +synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] +synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] +xref: EC:2.1.1.94 +xref: MetaCyc:2.1.1.94-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030767 +name: 3-hydroxyanthranilate 4-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate." [EC:2.1.1.97] +synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97] +synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97] +xref: EC:2.1.1.97 +xref: MetaCyc:2.1.1.97-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030768 +name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxy-tabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline." [EC:2.1.1.99] +synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99] +synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] +synonym: "NMT activity" EXACT [EC:2.1.1.99] +synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] +synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] +xref: EC:2.1.1.99 +xref: MetaCyc:2.1.1.99-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030769 +name: macrocin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin." [EC:2.1.1.101] +subset: gosubset_prok +synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101] +synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101] +synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101] +xref: EC:2.1.1.101 +xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030770 +name: demethylmacrocin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin." [EC:2.1.1.102] +synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102] +synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102] +xref: EC:2.1.1.102 +xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030771 +name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-benzoyl-4-hydroxyanthranilate = S-adenosyl-L-homocysteine + N-benzoyl-4-methoxyanthranilate." [EC:2.1.1.105] +synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105] +synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105] +synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105] +xref: EC:2.1.1.105 +xref: MetaCyc:2.1.1.105-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030772 +name: tryptophan 2-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan." [EC:2.1.1.106] +synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106] +synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] +synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] +xref: EC:2.1.1.106 +xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030773 +name: 6-hydroxymellein O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein." [EC:2.1.1.108] +synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108] +synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108] +xref: EC:2.1.1.108 +xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030774 +name: anthranilate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + N-methylanthranilate." [EC:2.1.1.111] +synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111] +synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111] +xref: EC:2.1.1.111 +xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030775 +name: glucuronoxylan 4-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112] +synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112] +xref: EC:2.1.1.112 +xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030776 +name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115] +synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] +synonym: "(rs)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] +synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115] +synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] +xref: EC:2.1.1.115 +xref: MetaCyc:2.1.1.115-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030777 +name: (S)-scoulerine 9-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine." [EC:2.1.1.117] +synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] +synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] +xref: EC:2.1.1.117 +xref: MetaCyc:2.1.1.117-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030778 +name: columbamine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine." [EC:2.1.1.118] +synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118] +xref: EC:2.1.1.118 +xref: MetaCyc:2.1.1.118-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030779 +name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine." [EC:2.1.1.119] +synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119] +xref: EC:2.1.1.119 +xref: MetaCyc:2.1.1.119-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030780 +name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine." [EC:2.1.1.120] +synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120] +xref: EC:2.1.1.120 +xref: MetaCyc:2.1.1.120-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030781 +name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121] +synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121] +xref: EC:2.1.1.121 +xref: MetaCyc:2.1.1.121-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030782 +name: (S)-tetrahydroprotoberberine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122] +synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] +synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] +xref: EC:2.1.1.122 +xref: MetaCyc:2.1.1.122-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030783 +name: [cytochrome c]-methionine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123] +synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] +synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] +xref: EC:2.1.1.123 +xref: MetaCyc:2.1.1.123-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030784 +name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116] +synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116] +xref: EC:2.1.1.116 +xref: MetaCyc:2.1.1.116-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030785 +name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] +synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127] +synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127] +synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127] +synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127] +synonym: "rubisco methyltransferase activity" EXACT [EC:2.1.1.127] +synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127] +synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127] +synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127] +xref: EC:2.1.1.127 +xref: MetaCyc:2.1.1.127-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030786 +name: (RS)-norcoclaurine 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128] +synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128] +xref: EC:2.1.1.128 +xref: MetaCyc:2.1.1.128-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030787 +name: inositol 4-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 4-methyl-myo-inositol." [EC:2.1.1.129] +synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] +synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129] +synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129] +synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] +xref: EC:2.1.1.129 +xref: MetaCyc:2.1.1.129-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030788 +name: precorrin-2 C20-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A." [EC:2.1.1.130] +subset: gosubset_prok +synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130] +synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130] +xref: EC:2.1.1.130 +xref: MetaCyc:2.1.1.130-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030789 +name: precorrin-3B C17-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131] +subset: gosubset_prok +synonym: "CobJ" RELATED [EC:2.1.1.131] +synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131] +synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131] +synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131] +xref: EC:2.1.1.131 +xref: MetaCyc:2.1.1.131-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030790 +name: chlorophenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136] +synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136] +synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] +synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] +xref: EC:2.1.1.136 +xref: MetaCyc:2.1.1.136-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030791 +name: arsenite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137] +comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). +synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137] +synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137] +synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137] +xref: EC:2.1.1.137 +xref: MetaCyc:2.1.1.137-RXN +xref: UM-BBD_enzymeID:e0515 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030792 +name: methylarsonite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138] +comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). +xref: EC:2.1.1.- +xref: MetaCyc:2.1.1.138-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030793 +name: 3'-demethylstaurosporine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine." [EC:2.1.1.139] +synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] +synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] +synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139] +xref: EC:2.1.1.139 +xref: MetaCyc:2.1.1.139-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030794 +name: (S)-coclaurine-N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140] +synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140] +xref: EC:2.1.1.140 +xref: MetaCyc:2.1.1.140-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030795 +name: jasmonate O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0045546 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141] +synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141] +synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141] +synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT [] +xref: EC:2.1.1.141 +xref: MetaCyc:RXN1F-28 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030796 +name: cycloartenol 24-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + (24R)-24-methylcycloarta-8,25-dien-3N2-ol." [EC:2.1.1.142] +synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142] +synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142] +xref: EC:2.1.1.142 +xref: MetaCyc:2.1.1.142-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030797 +name: 24-methylenesterol C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol." [EC:2.1.1.143] +synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143] +synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143] +synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143] +synonym: "SMT(2) activity" NARROW [EC:2.1.1.143] +synonym: "SMT2" RELATED [EC:2.1.1.143] +xref: EC:2.1.1.143 +xref: MetaCyc:2.1.1.143-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030798 +name: trans-aconitate 2-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate." [EC:2.1.1.144] +subset: gosubset_prok +synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144] +xref: EC:2.1.1.144 +xref: MetaCyc:RXN0-2441 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030799 +name: regulation of cyclic nucleotide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cyclic nucleotide metabolism" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +relationship: regulates GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0030800 +name: negative regulation of cyclic nucleotide metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "downregulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "inhibition of cyclic nucleotide metabolic process" NARROW [] +synonym: "negative regulation of cyclic nucleotide metabolism" EXACT [] +is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +relationship: negatively_regulates GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0030801 +name: positive regulation of cyclic nucleotide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cyclic nucleotide metabolic process" NARROW [] +synonym: "positive regulation of cyclic nucleotide metabolism" EXACT [] +synonym: "stimulation of cyclic nucleotide metabolic process" NARROW [] +synonym: "up regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "upregulation of cyclic nucleotide metabolic process" EXACT [] +is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +relationship: positively_regulates GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0030802 +name: regulation of cyclic nucleotide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cyclic nucleotide anabolism" EXACT [] +synonym: "regulation of cyclic nucleotide biosynthesis" EXACT [] +synonym: "regulation of cyclic nucleotide formation" EXACT [] +synonym: "regulation of cyclic nucleotide synthesis" EXACT [] +is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +relationship: regulates GO:0009190 ! cyclic nucleotide biosynthetic process + +[Term] +id: GO:0030803 +name: negative regulation of cyclic nucleotide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW [] +synonym: "negative regulation of cyclic nucleotide anabolism" EXACT [] +synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT [] +synonym: "negative regulation of cyclic nucleotide formation" EXACT [] +synonym: "negative regulation of cyclic nucleotide synthesis" EXACT [] +is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process +is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process +relationship: negatively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process + +[Term] +id: GO:0030804 +name: positive regulation of cyclic nucleotide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cyclic nucleotide biosynthetic process" NARROW [] +synonym: "positive regulation of cyclic nucleotide anabolism" EXACT [] +synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT [] +synonym: "positive regulation of cyclic nucleotide formation" EXACT [] +synonym: "positive regulation of cyclic nucleotide synthesis" EXACT [] +synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW [] +synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT [] +is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process +is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process +relationship: positively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process + +[Term] +id: GO:0030805 +name: regulation of cyclic nucleotide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cyclic nucleotide breakdown" EXACT [] +synonym: "regulation of cyclic nucleotide catabolism" EXACT [] +synonym: "regulation of cyclic nucleotide degradation" EXACT [] +is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process +is_a: GO:0030811 ! regulation of nucleotide catabolic process +relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process + +[Term] +id: GO:0030806 +name: negative regulation of cyclic nucleotide catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "downregulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "inhibition of cyclic nucleotide catabolic process" NARROW [] +synonym: "negative regulation of cyclic nucleotide breakdown" EXACT [] +synonym: "negative regulation of cyclic nucleotide catabolism" EXACT [] +synonym: "negative regulation of cyclic nucleotide degradation" EXACT [] +is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process +is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process +is_a: GO:0030812 ! negative regulation of nucleotide catabolic process +relationship: negatively_regulates GO:0009214 ! cyclic nucleotide catabolic process + +[Term] +id: GO:0030807 +name: positive regulation of cyclic nucleotide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cyclic nucleotide catabolic process" NARROW [] +synonym: "positive regulation of cyclic nucleotide breakdown" EXACT [] +synonym: "positive regulation of cyclic nucleotide catabolism" EXACT [] +synonym: "positive regulation of cyclic nucleotide degradation" EXACT [] +synonym: "stimulation of cyclic nucleotide catabolic process" NARROW [] +synonym: "up regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "upregulation of cyclic nucleotide catabolic process" EXACT [] +is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process +is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process +is_a: GO:0030813 ! positive regulation of nucleotide catabolic process +relationship: positively_regulates GO:0009214 ! cyclic nucleotide catabolic process + +[Term] +id: GO:0030808 +name: regulation of nucleotide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of nucleotide anabolism" EXACT [] +synonym: "regulation of nucleotide biosynthesis" EXACT [] +synonym: "regulation of nucleotide formation" EXACT [] +synonym: "regulation of nucleotide synthesis" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030809 +name: negative regulation of nucleotide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of nucleotide biosynthetic process" EXACT [] +synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] +synonym: "downregulation of nucleotide biosynthetic process" EXACT [] +synonym: "inhibition of nucleotide biosynthetic process" NARROW [] +synonym: "negative regulation of nucleotide anabolism" EXACT [] +synonym: "negative regulation of nucleotide biosynthesis" EXACT [] +synonym: "negative regulation of nucleotide formation" EXACT [] +synonym: "negative regulation of nucleotide synthesis" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030810 +name: positive regulation of nucleotide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "activation of nucleotide biosynthetic process" NARROW [] +synonym: "positive regulation of nucleotide anabolism" EXACT [] +synonym: "positive regulation of nucleotide biosynthesis" EXACT [] +synonym: "positive regulation of nucleotide formation" EXACT [] +synonym: "positive regulation of nucleotide synthesis" EXACT [] +synonym: "stimulation of nucleotide biosynthetic process" NARROW [] +synonym: "up regulation of nucleotide biosynthetic process" EXACT [] +synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] +synonym: "upregulation of nucleotide biosynthetic process" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030811 +name: regulation of nucleotide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of nucleotide breakdown" EXACT [] +synonym: "regulation of nucleotide catabolism" EXACT [] +synonym: "regulation of nucleotide degradation" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0030812 +name: negative regulation of nucleotide catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of nucleotide catabolic process" EXACT [] +synonym: "down-regulation of nucleotide catabolic process" EXACT [] +synonym: "downregulation of nucleotide catabolic process" EXACT [] +synonym: "inhibition of nucleotide catabolic process" NARROW [] +synonym: "negative regulation of nucleotide breakdown" EXACT [] +synonym: "negative regulation of nucleotide catabolism" EXACT [] +synonym: "negative regulation of nucleotide degradation" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0030813 +name: positive regulation of nucleotide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] +subset: gosubset_prok +synonym: "activation of nucleotide catabolic process" NARROW [] +synonym: "positive regulation of nucleotide breakdown" EXACT [] +synonym: "positive regulation of nucleotide catabolism" EXACT [] +synonym: "positive regulation of nucleotide degradation" EXACT [] +synonym: "stimulation of nucleotide catabolic process" NARROW [] +synonym: "up regulation of nucleotide catabolic process" EXACT [] +synonym: "up-regulation of nucleotide catabolic process" EXACT [] +synonym: "upregulation of nucleotide catabolic process" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +relationship: positively_regulates GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0030814 +name: regulation of cAMP metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of 3',5' cAMP metabolic process" EXACT [] +synonym: "regulation of 3',5' cAMP metabolism" EXACT [] +synonym: "regulation of 3',5'-cAMP metabolic process" EXACT [] +synonym: "regulation of 3',5'-cAMP metabolism" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "regulation of cAMP metabolism" EXACT [] +synonym: "regulation of cyclic AMP metabolic process" EXACT [] +synonym: "regulation of cyclic AMP metabolism" EXACT [] +is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process +relationship: regulates GO:0046058 ! cAMP metabolic process + +[Term] +id: GO:0030815 +name: negative regulation of cAMP metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cAMP metabolic process" EXACT [] +synonym: "down-regulation of cAMP metabolic process" EXACT [] +synonym: "downregulation of cAMP metabolic process" EXACT [] +synonym: "inhibition of cAMP metabolic process" NARROW [] +synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT [] +synonym: "negative regulation of 3',5' cAMP metabolism" EXACT [] +synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT [] +synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "negative regulation of cAMP metabolism" EXACT [] +synonym: "negative regulation of cyclic AMP metabolic process" EXACT [] +synonym: "negative regulation of cyclic AMP metabolism" EXACT [] +is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process +is_a: GO:0030814 ! regulation of cAMP metabolic process +relationship: negatively_regulates GO:0046058 ! cAMP metabolic process + +[Term] +id: GO:0030816 +name: positive regulation of cAMP metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cAMP metabolic process" NARROW [] +synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT [] +synonym: "positive regulation of 3',5' cAMP metabolism" EXACT [] +synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT [] +synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "positive regulation of cAMP metabolism" EXACT [] +synonym: "positive regulation of cyclic AMP metabolic process" EXACT [] +synonym: "positive regulation of cyclic AMP metabolism" EXACT [] +synonym: "stimulation of cAMP metabolic process" NARROW [] +synonym: "up regulation of cAMP metabolic process" EXACT [] +synonym: "up-regulation of cAMP metabolic process" EXACT [] +synonym: "upregulation of cAMP metabolic process" EXACT [] +is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process +is_a: GO:0030814 ! regulation of cAMP metabolic process +relationship: positively_regulates GO:0046058 ! cAMP metabolic process + +[Term] +id: GO:0030817 +name: regulation of cAMP biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of 3',5' cAMP biosynthesis" EXACT [] +synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT [] +synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT [] +synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "regulation of cAMP anabolism" EXACT [] +synonym: "regulation of cAMP biosynthesis" EXACT [] +synonym: "regulation of cAMP formation" EXACT [] +synonym: "regulation of cAMP synthesis" EXACT [] +synonym: "regulation of cyclic AMP biosynthesis" EXACT [] +synonym: "regulation of cyclic AMP biosynthetic process" EXACT [] +is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030814 ! regulation of cAMP metabolic process +relationship: regulates GO:0006171 ! cAMP biosynthetic process + +[Term] +id: GO:0030818 +name: negative regulation of cAMP biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cAMP biosynthetic process" EXACT [] +synonym: "down-regulation of cAMP biosynthetic process" EXACT [] +synonym: "downregulation of cAMP biosynthetic process" EXACT [] +synonym: "inhibition of cAMP biosynthetic process" NARROW [] +synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT [] +synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT [] +synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT [] +synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "negative regulation of cAMP anabolism" EXACT [] +synonym: "negative regulation of cAMP biosynthesis" EXACT [] +synonym: "negative regulation of cAMP formation" EXACT [] +synonym: "negative regulation of cAMP synthesis" EXACT [] +synonym: "negative regulation of cyclic AMP biosynthesis" EXACT [] +synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT [] +is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030815 ! negative regulation of cAMP metabolic process +is_a: GO:0030817 ! regulation of cAMP biosynthetic process +relationship: negatively_regulates GO:0006171 ! cAMP biosynthetic process + +[Term] +id: GO:0030819 +name: positive regulation of cAMP biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cAMP biosynthetic process" NARROW [] +synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT [] +synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT [] +synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT [] +synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "positive regulation of cAMP anabolism" EXACT [] +synonym: "positive regulation of cAMP biosynthesis" EXACT [] +synonym: "positive regulation of cAMP formation" EXACT [] +synonym: "positive regulation of cAMP synthesis" EXACT [] +synonym: "positive regulation of cyclic AMP biosynthesis" EXACT [] +synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT [] +synonym: "stimulation of cAMP biosynthetic process" NARROW [] +synonym: "up regulation of cAMP biosynthetic process" EXACT [] +synonym: "up-regulation of cAMP biosynthetic process" EXACT [] +synonym: "upregulation of cAMP biosynthetic process" EXACT [] +is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030816 ! positive regulation of cAMP metabolic process +is_a: GO:0030817 ! regulation of cAMP biosynthetic process +relationship: positively_regulates GO:0006171 ! cAMP biosynthetic process + +[Term] +id: GO:0030820 +name: regulation of cAMP catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of 3',5' cAMP catabolic process" EXACT [] +synonym: "regulation of 3',5' cAMP catabolism" EXACT [] +synonym: "regulation of 3',5'-cAMP catabolic process" EXACT [] +synonym: "regulation of 3',5'-cAMP catabolism" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "regulation of cAMP breakdown" EXACT [] +synonym: "regulation of cAMP catabolism" EXACT [] +synonym: "regulation of cAMP degradation" EXACT [] +synonym: "regulation of cyclic AMP catabolic process" EXACT [] +synonym: "regulation of cyclic AMP catabolism" EXACT [] +is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process +is_a: GO:0030814 ! regulation of cAMP metabolic process +relationship: regulates GO:0006198 ! cAMP catabolic process + +[Term] +id: GO:0030821 +name: negative regulation of cAMP catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cAMP catabolic process" EXACT [] +synonym: "down-regulation of cAMP catabolic process" EXACT [] +synonym: "downregulation of cAMP catabolic process" EXACT [] +synonym: "inhibition of cAMP catabolic process" NARROW [] +synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT [] +synonym: "negative regulation of 3',5' cAMP catabolism" EXACT [] +synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT [] +synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "negative regulation of cAMP breakdown" EXACT [] +synonym: "negative regulation of cAMP catabolism" EXACT [] +synonym: "negative regulation of cAMP degradation" EXACT [] +synonym: "negative regulation of cyclic AMP catabolic process" EXACT [] +synonym: "negative regulation of cyclic AMP catabolism" EXACT [] +is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process +is_a: GO:0030815 ! negative regulation of cAMP metabolic process +is_a: GO:0030820 ! regulation of cAMP catabolic process +relationship: negatively_regulates GO:0006198 ! cAMP catabolic process + +[Term] +id: GO:0030822 +name: positive regulation of cAMP catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cAMP catabolic process" NARROW [] +synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT [] +synonym: "positive regulation of 3',5' cAMP catabolism" EXACT [] +synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT [] +synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "positive regulation of cAMP breakdown" EXACT [] +synonym: "positive regulation of cAMP catabolism" EXACT [] +synonym: "positive regulation of cAMP degradation" EXACT [] +synonym: "positive regulation of cyclic AMP catabolic process" EXACT [] +synonym: "positive regulation of cyclic AMP catabolism" EXACT [] +synonym: "stimulation of cAMP catabolic process" NARROW [] +synonym: "up regulation of cAMP catabolic process" EXACT [] +synonym: "up-regulation of cAMP catabolic process" EXACT [] +synonym: "upregulation of cAMP catabolic process" EXACT [] +is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process +is_a: GO:0030816 ! positive regulation of cAMP metabolic process +is_a: GO:0030820 ! regulation of cAMP catabolic process +relationship: positively_regulates GO:0006198 ! cAMP catabolic process + +[Term] +id: GO:0030823 +name: regulation of cGMP metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cGMP metabolism" EXACT [] +is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process +relationship: regulates GO:0046068 ! cGMP metabolic process + +[Term] +id: GO:0030824 +name: negative regulation of cGMP metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cGMP metabolic process" EXACT [] +synonym: "down-regulation of cGMP metabolic process" EXACT [] +synonym: "downregulation of cGMP metabolic process" EXACT [] +synonym: "inhibition of cGMP metabolic process" NARROW [] +synonym: "negative regulation of cGMP metabolism" EXACT [] +is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process +is_a: GO:0030823 ! regulation of cGMP metabolic process +relationship: negatively_regulates GO:0046068 ! cGMP metabolic process + +[Term] +id: GO:0030825 +name: positive regulation of cGMP metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cGMP metabolic process" NARROW [] +synonym: "positive regulation of cGMP metabolism" EXACT [] +synonym: "stimulation of cGMP metabolic process" NARROW [] +synonym: "up regulation of cGMP metabolic process" EXACT [] +synonym: "up-regulation of cGMP metabolic process" EXACT [] +synonym: "upregulation of cGMP metabolic process" EXACT [] +is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process +is_a: GO:0030823 ! regulation of cGMP metabolic process +relationship: positively_regulates GO:0046068 ! cGMP metabolic process + +[Term] +id: GO:0030826 +name: regulation of cGMP biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cGMP anabolism" EXACT [] +synonym: "regulation of cGMP biosynthesis" EXACT [] +synonym: "regulation of cGMP formation" EXACT [] +synonym: "regulation of cGMP synthesis" EXACT [] +is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030823 ! regulation of cGMP metabolic process +relationship: regulates GO:0006182 ! cGMP biosynthetic process + +[Term] +id: GO:0030827 +name: negative regulation of cGMP biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cGMP biosynthetic process" EXACT [] +synonym: "down-regulation of cGMP biosynthetic process" EXACT [] +synonym: "downregulation of cGMP biosynthetic process" EXACT [] +synonym: "inhibition of cGMP biosynthetic process" NARROW [] +synonym: "negative regulation of cGMP anabolism" EXACT [] +synonym: "negative regulation of cGMP biosynthesis" EXACT [] +synonym: "negative regulation of cGMP formation" EXACT [] +synonym: "negative regulation of cGMP synthesis" EXACT [] +is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030824 ! negative regulation of cGMP metabolic process +is_a: GO:0030826 ! regulation of cGMP biosynthetic process +relationship: negatively_regulates GO:0006182 ! cGMP biosynthetic process + +[Term] +id: GO:0030828 +name: positive regulation of cGMP biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cGMP biosynthetic process" NARROW [] +synonym: "positive regulation of cGMP anabolism" EXACT [] +synonym: "positive regulation of cGMP biosynthesis" EXACT [] +synonym: "positive regulation of cGMP formation" EXACT [] +synonym: "positive regulation of cGMP synthesis" EXACT [] +synonym: "stimulation of cGMP biosynthetic process" NARROW [] +synonym: "up regulation of cGMP biosynthetic process" EXACT [] +synonym: "up-regulation of cGMP biosynthetic process" EXACT [] +synonym: "upregulation of cGMP biosynthetic process" EXACT [] +is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process +is_a: GO:0030825 ! positive regulation of cGMP metabolic process +is_a: GO:0030826 ! regulation of cGMP biosynthetic process +relationship: positively_regulates GO:0006182 ! cGMP biosynthetic process + +[Term] +id: GO:0030829 +name: regulation of cGMP catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cGMP breakdown" EXACT [] +synonym: "regulation of cGMP catabolism" EXACT [] +synonym: "regulation of cGMP degradation" EXACT [] +is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process +is_a: GO:0030823 ! regulation of cGMP metabolic process +relationship: regulates GO:0046069 ! cGMP catabolic process + +[Term] +id: GO:0030830 +name: negative regulation of cGMP catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cGMP catabolic process" EXACT [] +synonym: "down-regulation of cGMP catabolic process" EXACT [] +synonym: "downregulation of cGMP catabolic process" EXACT [] +synonym: "inhibition of cGMP catabolic process" NARROW [] +synonym: "negative regulation of cGMP breakdown" EXACT [] +synonym: "negative regulation of cGMP catabolism" EXACT [] +synonym: "negative regulation of cGMP degradation" EXACT [] +is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process +is_a: GO:0030824 ! negative regulation of cGMP metabolic process +is_a: GO:0030829 ! regulation of cGMP catabolic process +relationship: negatively_regulates GO:0046069 ! cGMP catabolic process + +[Term] +id: GO:0030831 +name: positive regulation of cGMP catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cGMP catabolic process" NARROW [] +synonym: "positive regulation of cGMP breakdown" EXACT [] +synonym: "positive regulation of cGMP catabolism" EXACT [] +synonym: "positive regulation of cGMP degradation" EXACT [] +synonym: "stimulation of cGMP catabolic process" NARROW [] +synonym: "up regulation of cGMP catabolic process" EXACT [] +synonym: "up-regulation of cGMP catabolic process" EXACT [] +synonym: "upregulation of cGMP catabolic process" EXACT [] +is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process +is_a: GO:0030825 ! positive regulation of cGMP metabolic process +is_a: GO:0030829 ! regulation of cGMP catabolic process +relationship: positively_regulates GO:0046069 ! cGMP catabolic process + +[Term] +id: GO:0030832 +name: regulation of actin filament length +namespace: biological_process +def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0032535 ! regulation of cellular component size +is_a: GO:0032956 ! regulation of actin cytoskeleton organization + +[Term] +id: GO:0030833 +name: regulation of actin filament polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] +synonym: "regulation of actin polymerization" EXACT [] +is_a: GO:0008064 ! regulation of actin polymerization or depolymerization +is_a: GO:0032271 ! regulation of protein polymerization +relationship: regulates GO:0030041 ! actin filament polymerization + +[Term] +id: GO:0030834 +name: regulation of actin filament depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] +synonym: "regulation of actin depolymerization" EXACT [] +is_a: GO:0008064 ! regulation of actin polymerization or depolymerization +is_a: GO:0043244 ! regulation of protein complex disassembly +relationship: regulates GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030835 +name: negative regulation of actin filament depolymerization +namespace: biological_process +alt_id: GO:0030044 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] +comment: This term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837'). +synonym: "actin filament stabilization" EXACT [] +synonym: "down regulation of actin filament depolymerization" EXACT [] +synonym: "down-regulation of actin filament depolymerization" EXACT [] +synonym: "downregulation of actin filament depolymerization" EXACT [] +synonym: "inhibition of actin filament depolymerization" NARROW [] +synonym: "negative regulation of actin depolymerization" EXACT [] +synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] +is_a: GO:0030834 ! regulation of actin filament depolymerization +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0043242 ! negative regulation of protein complex disassembly +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030836 +name: positive regulation of actin filament depolymerization +namespace: biological_process +alt_id: GO:0030045 +def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah] +comment: This term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838'). +synonym: "actin filament destabilization" EXACT [] +synonym: "activation of actin filament depolymerization" NARROW [] +synonym: "positive regulation of actin depolymerization" EXACT [] +synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of actin filament depolymerization" NARROW [] +synonym: "up regulation of actin filament depolymerization" EXACT [] +synonym: "up-regulation of actin filament depolymerization" EXACT [] +synonym: "upregulation of actin filament depolymerization" EXACT [] +is_a: GO:0030834 ! regulation of actin filament depolymerization +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0043243 ! positive regulation of protein complex disassembly +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030837 +name: negative regulation of actin filament polymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] +comment: This term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835'). +synonym: "down regulation of actin filament polymerization" EXACT [] +synonym: "down-regulation of actin filament polymerization" EXACT [] +synonym: "downregulation of actin filament polymerization" EXACT [] +synonym: "inhibition of actin filament polymerization" NARROW [] +synonym: "negative regulation of actin polymerization" EXACT [] +synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] +is_a: GO:0030833 ! regulation of actin filament polymerization +is_a: GO:0032272 ! negative regulation of protein polymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0030041 ! actin filament polymerization + +[Term] +id: GO:0030838 +name: positive regulation of actin filament polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah] +comment: This term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836'). +synonym: "activation of actin filament polymerization" NARROW [] +synonym: "positive regulation of actin polymerization" EXACT [] +synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of actin filament polymerization" NARROW [] +synonym: "up regulation of actin filament polymerization" EXACT [] +synonym: "up-regulation of actin filament polymerization" EXACT [] +synonym: "upregulation of actin filament polymerization" EXACT [] +is_a: GO:0030833 ! regulation of actin filament polymerization +is_a: GO:0032273 ! positive regulation of protein polymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0030041 ! actin filament polymerization + +[Term] +id: GO:0030839 +name: regulation of intermediate filament polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah] +is_a: GO:0032271 ! regulation of protein polymerization +is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization +relationship: regulates GO:0045107 ! intermediate filament polymerization + +[Term] +id: GO:0030840 +name: negative regulation of intermediate filament polymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] +comment: This term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843'). +synonym: "down regulation of intermediate filament polymerization" EXACT [] +synonym: "down-regulation of intermediate filament polymerization" EXACT [] +synonym: "downregulation of intermediate filament polymerization" EXACT [] +synonym: "inhibition of intermediate filament polymerization" NARROW [] +synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +is_a: GO:0030839 ! regulation of intermediate filament polymerization +is_a: GO:0032272 ! negative regulation of protein polymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization + +[Term] +id: GO:0030841 +name: positive regulation of intermediate filament polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] +comment: This term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844'). +synonym: "activation of intermediate filament polymerization" NARROW [] +synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of intermediate filament polymerization" NARROW [] +synonym: "up regulation of intermediate filament polymerization" EXACT [] +synonym: "up-regulation of intermediate filament polymerization" EXACT [] +synonym: "upregulation of intermediate filament polymerization" EXACT [] +is_a: GO:0030839 ! regulation of intermediate filament polymerization +is_a: GO:0032273 ! positive regulation of protein polymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0045107 ! intermediate filament polymerization + +[Term] +id: GO:0030842 +name: regulation of intermediate filament depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0043244 ! regulation of protein complex disassembly +is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization +relationship: regulates GO:0045106 ! intermediate filament depolymerization + +[Term] +id: GO:0030843 +name: negative regulation of intermediate filament depolymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] +comment: This term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840'). +synonym: "down regulation of intermediate filament depolymerization" EXACT [] +synonym: "down-regulation of intermediate filament depolymerization" EXACT [] +synonym: "downregulation of intermediate filament depolymerization" EXACT [] +synonym: "inhibition of intermediate filament depolymerization" NARROW [] +synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +is_a: GO:0030842 ! regulation of intermediate filament depolymerization +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0043242 ! negative regulation of protein complex disassembly +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization + +[Term] +id: GO:0030844 +name: positive regulation of intermediate filament depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] +comment: This term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841'). +synonym: "activation of intermediate filament depolymerization" NARROW [] +synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of intermediate filament depolymerization" NARROW [] +synonym: "up regulation of intermediate filament depolymerization" EXACT [] +synonym: "up-regulation of intermediate filament depolymerization" EXACT [] +synonym: "upregulation of intermediate filament depolymerization" EXACT [] +is_a: GO:0030842 ! regulation of intermediate filament depolymerization +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0043243 ! positive regulation of protein complex disassembly +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization + +[Term] +id: GO:0030845 +name: inhibition of phospholipase C activity +namespace: biological_process +def: "A signaling pathway that results in preventing the activation of phospholipase C in response to the signal." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] +comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase inhibitor activity ; GO:0004859'. +synonym: "phospholipase C inhibition" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051346 ! negative regulation of hydrolase activity +relationship: part_of GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0030846 +name: termination of RNA polymerase II transcription, poly(A)-coupled +namespace: biological_process +def: "The process by which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [PMID:12944462] +synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED [] +synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [] +is_a: GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:0030847 +name: termination of RNA polymerase II transcription, poly(A)-independent +namespace: biological_process +def: "The process by which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [PMID:12944462] +synonym: "transcription termination from Pol II promoter, poly(A)-independent" RELATED [] +synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" RELATED [] +is_a: GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:0030848 +name: threo-3-hydroxyaspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: threo-3-hydroxy-L-aspartate = oxaloacetate + NH3." [EC:4.3.1.16, PMID:10481099] +synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099] +synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] +synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16] +synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16] +synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] +xref: EC:4.3.1.16 +xref: MetaCyc:4.3.1.16-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0030849 +name: autosome +namespace: cellular_component +def: "Any chromosome other than a sex chromosome." [GOC:mah] +comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0030850 +name: prostate gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] +synonym: "prostate development" EXACT [] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0001655 ! urogenital system development + +[Term] +id: GO:0030851 +name: granulocyte differentiation +namespace: biological_process +def: "The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] +synonym: "granulocyte cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030852 +name: regulation of granulocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030853 +name: negative regulation of granulocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] +synonym: "down regulation of granulocyte differentiation" EXACT [] +synonym: "down-regulation of granulocyte differentiation" EXACT [] +synonym: "downregulation of granulocyte differentiation" EXACT [] +synonym: "inhibition of granulocyte differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: negatively_regulates GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030854 +name: positive regulation of granulocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] +synonym: "activation of granulocyte differentiation" NARROW [] +synonym: "stimulation of granulocyte differentiation" NARROW [] +synonym: "up regulation of granulocyte differentiation" EXACT [] +synonym: "up-regulation of granulocyte differentiation" EXACT [] +synonym: "upregulation of granulocyte differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: positively_regulates GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030855 +name: epithelial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0030856 +name: regulation of epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0030857 +name: negative regulation of epithelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] +synonym: "down regulation of epithelial cell differentiation" EXACT [] +synonym: "down-regulation of epithelial cell differentiation" EXACT [] +synonym: "downregulation of epithelial cell differentiation" EXACT [] +synonym: "inhibition of epithelial cell differentiation" NARROW [] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0030858 +name: positive regulation of epithelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] +synonym: "activation of epithelial cell differentiation" NARROW [] +synonym: "stimulation of epithelial cell differentiation" NARROW [] +synonym: "up regulation of epithelial cell differentiation" EXACT [] +synonym: "up-regulation of epithelial cell differentiation" EXACT [] +synonym: "upregulation of epithelial cell differentiation" EXACT [] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0030859 +name: polarized epithelial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium + +[Term] +id: GO:0030860 +name: regulation of polarized epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0030859 ! polarized epithelial cell differentiation + +[Term] +id: GO:0030861 +name: negative regulation of polarized epithelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] +synonym: "down regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "down-regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "downregulation of polarized epithelial cell differentiation" EXACT [] +synonym: "inhibition of polarized epithelial cell differentiation" NARROW [] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation +relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation + +[Term] +id: GO:0030862 +name: positive regulation of polarized epithelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah] +synonym: "activation of polarized epithelial cell differentiation" NARROW [] +synonym: "stimulation of polarized epithelial cell differentiation" NARROW [] +synonym: "up regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "up-regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "upregulation of polarized epithelial cell differentiation" EXACT [] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation +relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation + +[Term] +id: GO:0030863 +name: cortical cytoskeleton +namespace: cellular_component +def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] +is_a: GO:0005856 ! cytoskeleton +is_a: GO:0044448 ! cell cortex part + +[Term] +id: GO:0030864 +name: cortical actin cytoskeleton +namespace: cellular_component +def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] +is_a: GO:0030863 ! cortical cytoskeleton +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0030865 +name: cortical cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] +synonym: "cortical cytoskeleton organisation and biogenesis" EXACT [] +synonym: "cortical cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0030866 +name: cortical actin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] +synonym: "cortical actin cytoskeleton organisation and biogenesis" EXACT [] +synonym: "cortical actin cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0030865 ! cortical cytoskeleton organization + +[Term] +id: GO:0030867 +name: rough endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah] +synonym: "rough ER membrane" EXACT [] +is_a: GO:0005789 ! endoplasmic reticulum membrane +relationship: part_of GO:0005791 ! rough endoplasmic reticulum + +[Term] +id: GO:0030868 +name: smooth endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah] +synonym: "smooth ER membrane" EXACT [] +is_a: GO:0005789 ! endoplasmic reticulum membrane +relationship: part_of GO:0005790 ! smooth endoplasmic reticulum + +[Term] +id: GO:0030869 +name: RENT complex +namespace: cellular_component +def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389] +is_a: GO:0005677 ! chromatin silencing complex + +[Term] +id: GO:0030870 +name: Mre11 complex +namespace: cellular_component +def: "Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [GOC:mah, PMID:11988766] +synonym: "MRN complex" EXACT [] +synonym: "MRX complex" EXACT [] +synonym: "Rad50 complex" EXACT [] +synonym: "Rad50-Rad32-Nbs1 complex" EXACT [] +synonym: "RMX complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0030874 +name: nucleolar chromatin +namespace: cellular_component +def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah] +is_a: GO:0044452 ! nucleolar part +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000790 ! nuclear chromatin + +[Term] +id: GO:0030875 +name: rDNA protrusion +namespace: cellular_component +def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244] +comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. +synonym: "ribosomal DNA protrusion" EXACT [] +is_a: GO:0044452 ! nucleolar part +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0030874 ! nucleolar chromatin + +[Term] +id: GO:0030876 +name: interleukin-20 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-20; comprises an alpha and a beta subunit." [GOC:mah] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0030877 +name: beta-catenin destruction complex +namespace: cellular_component +def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] +synonym: "beta-catenin degradation complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0030878 +name: thyroid gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0030879 +name: mammary gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [PMID:9576833] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0030880 +name: RNA polymerase complex +namespace: cellular_component +def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "multisubunit RNA polymerase" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0030881 +name: beta-2-microglobulin binding +namespace: molecular_function +def: "Interacting selectively with beta-2-microglobulin." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030882 +name: lipid antigen binding +namespace: molecular_function +def: "Interacting selectively with a lipid antigen." [PMID:14500461] +is_a: GO:0003823 ! antigen binding +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0030883 +name: endogenous lipid antigen binding +namespace: molecular_function +def: "Interacting selectively with an endogenous cellular lipid antigen." [PMID:14500461] +is_a: GO:0030882 ! lipid antigen binding + +[Term] +id: GO:0030884 +name: exogenous lipid antigen binding +namespace: molecular_function +def: "Interacting selectively with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461] +is_a: GO:0030882 ! lipid antigen binding + +[Term] +id: GO:0030885 +name: regulation of myeloid dendritic cell activation +namespace: biological_process +def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0001773 ! myeloid dendritic cell activation + +[Term] +id: GO:0030886 +name: negative regulation of myeloid dendritic cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] +synonym: "down regulation of myeloid dendritic cell activation" EXACT [] +synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] +synonym: "downregulation of myeloid dendritic cell activation" EXACT [] +synonym: "inhibition of myeloid dendritic cell activation" NARROW [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0030885 ! regulation of myeloid dendritic cell activation +relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation + +[Term] +id: GO:0030887 +name: positive regulation of myeloid dendritic cell activation +namespace: biological_process +def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] +synonym: "activation of myeloid dendritic cell activation" NARROW [] +synonym: "stimulation of myeloid dendritic cell activation" NARROW [] +synonym: "up regulation of myeloid dendritic cell activation" EXACT [] +synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] +synonym: "upregulation of myeloid dendritic cell activation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0030885 ! regulation of myeloid dendritic cell activation +relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation + +[Term] +id: GO:0030888 +name: regulation of B cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah] +synonym: "regulation of B lymphocyte proliferation" EXACT [] +synonym: "regulation of B-cell proliferation" EXACT [] +synonym: "regulation of B-lymphocyte proliferation" EXACT [] +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0050864 ! regulation of B cell activation +relationship: regulates GO:0042100 ! B cell proliferation + +[Term] +id: GO:0030889 +name: negative regulation of B cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah] +synonym: "down regulation of B cell proliferation" EXACT [] +synonym: "down-regulation of B cell proliferation" EXACT [] +synonym: "downregulation of B cell proliferation" EXACT [] +synonym: "inhibition of B cell proliferation" NARROW [] +synonym: "negative regulation of B lymphocyte proliferation" EXACT [] +synonym: "negative regulation of B-cell proliferation" EXACT [] +synonym: "negative regulation of B-lymphocyte proliferation" EXACT [] +is_a: GO:0030888 ! regulation of B cell proliferation +is_a: GO:0050672 ! negative regulation of lymphocyte proliferation +is_a: GO:0050869 ! negative regulation of B cell activation +relationship: negatively_regulates GO:0042100 ! B cell proliferation + +[Term] +id: GO:0030890 +name: positive regulation of B cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah] +synonym: "activation of B cell proliferation" NARROW [] +synonym: "positive regulation of B lymphocyte proliferation" EXACT [] +synonym: "positive regulation of B-cell proliferation" EXACT [] +synonym: "positive regulation of B-lymphocyte proliferation" EXACT [] +synonym: "stimulation of B cell proliferation" NARROW [] +synonym: "up regulation of B cell proliferation" EXACT [] +synonym: "up-regulation of B cell proliferation" EXACT [] +synonym: "upregulation of B cell proliferation" EXACT [] +is_a: GO:0030888 ! regulation of B cell proliferation +is_a: GO:0050671 ! positive regulation of lymphocyte proliferation +is_a: GO:0050871 ! positive regulation of B cell activation +relationship: positively_regulates GO:0042100 ! B cell proliferation + +[Term] +id: GO:0030891 +name: VCB complex +namespace: cellular_component +def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071] +synonym: "pVHL-elongin C-elongin B complex" EXACT [] +synonym: "VHL complex" EXACT [] +synonym: "von Hippel-Lindau tumor suppressor complex" EXACT [] +is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex + +[Term] +id: GO:0030892 +name: mitotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522] +is_a: GO:0008278 ! cohesin complex + +[Term] +id: GO:0030893 +name: meiotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] +is_a: GO:0008278 ! cohesin complex + +[Term] +id: GO:0030894 +name: replisome +namespace: cellular_component +def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0005657 ! replication fork + +[Term] +id: GO:0030895 +name: apolipoprotein B mRNA editing enzyme complex +namespace: cellular_component +def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591] +synonym: "apoB mRNA editing enzyme complex" EXACT [] +synonym: "APOBEC" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0030896 +name: checkpoint clamp complex +namespace: cellular_component +def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] +comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. +synonym: "CCC" EXACT [] +synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0030897 +name: HOPS complex +namespace: cellular_component +def: "A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:10944212] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0030898 +name: actin-dependent ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "actin-activated ATPase activity" EXACT [] +is_a: GO:0042623 ! ATPase activity, coupled + +[Term] +id: GO:0030899 +name: calcium-dependent ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of calcium ion (Ca2+)." [GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +is_a: GO:0042623 ! ATPase activity, coupled + +[Term] +id: GO:0030900 +name: forebrain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain] +synonym: "prosencephalon development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0030901 +name: midbrain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain] +synonym: "mesencephalon development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0030902 +name: hindbrain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain] +synonym: "rhombencephalon development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0030903 +name: notochord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0030904 +name: retromer complex +namespace: cellular_component +def: "A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0030905 +name: retromer complex, outer shell +namespace: cellular_component +def: "One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer." [PMID:9700157] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0030904 ! retromer complex + +[Term] +id: GO:0030906 +name: retromer complex, inner shell +namespace: cellular_component +def: "One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p." [PMID:9700157] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0030904 ! retromer complex + +[Term] +id: GO:0030907 +name: MBF transcription complex +namespace: cellular_component +def: "A complex of two or three proteins that binds to the Mlu1 cell cycle box (MCB) promoter element and is involved in cell cycle-dependent regulation of transcription. In Saccharomyces the complex consists of Mbp1p and Swi6p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [PMID:9343385] +synonym: "DSC1 transcription factor complex" EXACT [] +synonym: "MBF" EXACT [] +synonym: "Mlu1-box binding factor" EXACT [] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0030908 +name: protein splicing +namespace: biological_process +def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0030909 +name: non-intein-mediated protein splicing +namespace: biological_process +def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030908 ! protein splicing + +[Term] +id: GO:0030910 +name: olfactory placode formation +namespace: biological_process +def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0043584 ! nose development +relationship: part_of GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0030911 +name: TPR domain binding +namespace: molecular_function +def: "Interacting selectively with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030912 +name: response to deep water +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah] +comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale. +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0030913 +name: paranodal junction assembly +namespace: biological_process +def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942] +synonym: "paranodal junction biosynthesis" EXACT [] +synonym: "paranodal junction formation" EXACT [] +is_a: GO:0007043 ! cell-cell junction assembly +relationship: part_of GO:0032288 ! myelin formation + +[Term] +id: GO:0030914 +name: STAGA complex +namespace: cellular_component +def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863] +comment: See also the cellular component term 'SAGA complex ; GO:0000124'. +synonym: "STAGA coactivator complex" EXACT [] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0030915 +name: Smc5-Smc6 complex +namespace: cellular_component +def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0030916 +name: otic vesicle formation +namespace: biological_process +def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh] +synonym: "otocyst biosynthesis" EXACT [] +synonym: "otocyst formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0042472 ! inner ear morphogenesis + +[Term] +id: GO:0030917 +name: midbrain-hindbrain boundary development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] +synonym: "isthmic organizer development" EXACT [] +synonym: "isthmomesencephalic boundary development" EXACT [] +synonym: "isthmus development" EXACT [] +synonym: "MHB development" EXACT [] +synonym: "midbrain-hindbrain orgainizer development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007417 ! central nervous system development +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0030919 +name: peptidyl-serine O-acetylation +namespace: biological_process +def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364] +subset: gosubset_prok +xref: RESID:AA0364 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030920 ! peptidyl-serine acetylation + +[Term] +id: GO:0030920 +name: peptidyl-serine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-serine." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006473 ! protein amino acid acetylation + +[Term] +id: GO:0030921 +name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine +namespace: biological_process +def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183] +subset: gosubset_prok +xref: RESID:AA0183 +is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation + +[Term] +id: GO:0030922 +name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine +namespace: biological_process +def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365] +subset: gosubset_prok +xref: RESID:AA0365 +is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation + +[Term] +id: GO:0030923 +name: metal incorporation into metallo-oxygen cluster +namespace: biological_process +def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0030924 +name: manganese incorporation into metallo-oxygen cluster +namespace: biological_process +def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030925 +name: calcium incorporation into metallo-oxygen cluster +namespace: biological_process +def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030926 +name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide +namespace: biological_process +def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] +subset: gosubset_prok +xref: RESID:AA0366 +is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030927 +name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide +namespace: biological_process +def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] +subset: gosubset_prok +xref: RESID:AA0366 +is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030928 +name: dopachrome decarboxylase activity +namespace: molecular_function +def: "Catalysis of the decarboxylation of L-dopachrome to form 5,6-dihydroxyindole." [PMID:12164780] +synonym: "dopachrome conversion activity" BROAD [] +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0030929 +name: ADPG pyrophosphorylase complex +namespace: cellular_component +def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0030930 +name: homotetrameric ADPG pyrophosphorylase complex +namespace: cellular_component +def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "ADPG pyrophosphorylase complex (sensu Bacteria)" EXACT [] +is_a: GO:0030929 ! ADPG pyrophosphorylase complex + +[Term] +id: GO:0030931 +name: heterotetrameric ADPG pyrophosphorylase complex +namespace: cellular_component +def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mah, GOC:mtg_sensu] +synonym: "ADPG pyrophosphorylase complex (sensu Eukaryota)" EXACT [] +is_a: GO:0030929 ! ADPG pyrophosphorylase complex + +[Term] +id: GO:0030932 +name: amyloplast ADPG pyrophosphorylase complex +namespace: cellular_component +def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah] +is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex +relationship: part_of GO:0009501 ! amyloplast + +[Term] +id: GO:0030933 +name: chloroplast ADPG pyrophosphorylase complex +namespace: cellular_component +def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah] +is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex +is_a: GO:0044434 ! chloroplast part + +[Term] +id: GO:0030934 +name: anchoring collagen +namespace: cellular_component +def: "Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976] +synonym: "connecting collagen" EXACT [ISBN:0721639976] +synonym: "linking collagen" EXACT [ISBN:0721639976] +is_a: GO:0005581 ! collagen + +[Term] +id: GO:0030935 +name: sheet-forming collagen +namespace: cellular_component +def: "Any collagen polymer in which collagen triple helices associate to form sheet-like networks." [ISBN:0721639976] +synonym: "network-forming collagen" EXACT [ISBN:0815316194] +is_a: GO:0005581 ! collagen + +[Term] +id: GO:0030936 +name: transmembrane collagen +namespace: cellular_component +def: "Any collagen polymer that passes through a lipid bilayer membrane." [ISBN:0721639976] +synonym: "MACIT" EXACT [ISBN:0198599587] +is_a: GO:0005581 ! collagen + +[Term] +id: GO:0030937 +name: collagen type XVII +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina." [ISBN:0721639976] +is_a: GO:0030936 ! transmembrane collagen + +[Term] +id: GO:0030938 +name: collagen type XVIII +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976] +is_a: GO:0030934 ! anchoring collagen + +[Term] +id: GO:0030939 +name: response to long-day photoperiod +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0048571 + +[Term] +id: GO:0030940 +name: response to short-day photoperiod +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj] +comment: This term was made obsolete because it was wrongly defined. +is_obsolete: true +consider: GO:0048572 + +[Term] +id: GO:0030941 +name: chloroplast targeting sequence binding +namespace: molecular_function +def: "Interacting selectively with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0030942 +name: endoplasmic reticulum signal peptide binding +namespace: molecular_function +def: "Interacting selectively with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] +synonym: "ER signal peptide binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0030943 +name: mitochondrion targeting sequence binding +namespace: molecular_function +def: "Interacting selectively with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah] +synonym: "mitochondrial targeting sequence binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0030944 +name: DDEL sequence binding +namespace: molecular_function +def: "Interacting selectively with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah] +is_a: GO:0046923 ! ER retention sequence binding + +[Term] +id: GO:0030945 +name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate +namespace: molecular_function +def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd] +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0030946 +name: protein tyrosine phosphatase activity, metal-dependent +namespace: molecular_function +def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate, by a mechanism that requires metal ions." [GOC:mah] +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0030947 +name: regulation of vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] +synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] +synonym: "regulation of VEGF receptor signaling pathway" EXACT [] +synonym: "regulation of VEGF receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0030948 +name: negative regulation of vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] +synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] +synonym: "negative regulation of VEGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of VEGF receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0030949 +name: positive regulation of vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] +synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] +synonym: "positive regulation of VEGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of VEGF receptor signalling pathway" EXACT [] +synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway +relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0030950 +name: establishment or maintenance of actin cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity + +[Term] +id: GO:0030951 +name: establishment or maintenance of microtubule cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity + +[Term] +id: GO:0030952 +name: establishment or maintenance of cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] +is_a: GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0030953 +name: spindle astral microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] +synonym: "astral microtubule organisation and biogenesis" EXACT [] +synonym: "astral microtubule organization and biogenesis" EXACT [] +is_a: GO:0007051 ! spindle organization +is_a: GO:0031122 ! cytoplasmic microtubule organization + +[Term] +id: GO:0030954 +name: spindle astral microtubule nucleation +namespace: biological_process +def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah] +is_a: GO:0007020 ! microtubule nucleation +is_a: GO:0030953 ! spindle astral microtubule organization + +[Term] +id: GO:0030955 +name: potassium ion binding +namespace: molecular_function +def: "Interacting selectively with potassium (K+) ions." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031420 ! alkali metal ion binding + +[Term] +id: GO:0030956 +name: glutamyl-tRNA(Gln) amidotransferase complex +namespace: cellular_component +def: "Complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutamyl-tRNA(Gln) amidotransferase activity ; GO:0017068'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0030957 +name: Tat protein binding +namespace: molecular_function +def: "Interacting selectively with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0030958 +name: RITS complex +namespace: cellular_component +def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433] +is_a: GO:0031332 ! RNAi effector complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0005720 ! nuclear heterochromatin + +[Term] +id: GO:0030959 +name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine +namespace: biological_process +def: "The posttranslation modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367] +subset: gosubset_prok +xref: RESID:AA0367 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0030960 +name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine +namespace: biological_process +def: "The posttranslation modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368] +subset: gosubset_prok +xref: RESID:AA0368 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0030961 +name: peptidyl-arginine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0030962 +name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine +namespace: biological_process +def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369] +subset: gosubset_prok +xref: RESID:AA0369 +is_a: GO:0030961 ! peptidyl-arginine hydroxylation + +[Term] +id: GO:0030963 +name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine +namespace: biological_process +def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370] +subset: gosubset_prok +xref: RESID:AA0370 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0030964 +name: NADH dehydrogenase complex +namespace: cellular_component +alt_id: GO:0030025 +alt_id: GO:0030966 +alt_id: GO:0031675 +alt_id: GO:0031677 +alt_id: GO:0031678 +alt_id: GO:0045280 +def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyses the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. +subset: goslim_pir +subset: gosubset_prok +synonym: "Complex I" EXACT [] +synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW [] +synonym: "NADH dehydrogenase complex (plastoquinone) (sensu Cyanobacteria)" NARROW [] +synonym: "NADH dehydrogenase complex (quinone) (sensu Bacteria)" NARROW [] +synonym: "NADH dehydrogenase complex (ubiquinone) (sensu Bacteria)" NARROW [] +synonym: "NADH:plastoquinone reductase complex" NARROW [] +synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0030965 +name: plasma membrane electron transport, NADH to quinone +namespace: biological_process +def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd] +subset: gosubset_prok +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport + +[Term] +id: GO:0030967 +name: ER-nuclear sterol response pathway +namespace: biological_process +def: "The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of sterol depletion, and resulting in the activation of transcription by SREBP." [GOC:mah, PMID:12923525] +synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT [] +synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT [] +synonym: "ER to nucleus sterol response pathway" EXACT [] +is_a: GO:0006991 ! response to sterol depletion +is_a: GO:0032933 ! SREBP-mediated signaling pathway + +[Term] +id: GO:0030968 +name: endoplasmic reticulum unfolded protein response +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763] +comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any cellular response to the presence of unfolded proteins anywhere in the cell. Also see 'ER-associated protein catabolic process ; GO:0030433'. +synonym: "ER unfolded protein response" EXACT [] +synonym: "erUPR" EXACT [] +synonym: "SREBP-mediated signalling pathway" RELATED [] +is_a: GO:0006984 ! ER-nuclear signaling pathway +is_a: GO:0034620 ! cellular response to unfolded protein +is_a: GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:0030969 +name: UFP-specific transcription factor mRNA processing during unfolded protein response +namespace: biological_process +def: "The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763] +synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED [] +synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED [] +is_a: GO:0006397 ! mRNA processing +relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:0030970 +name: retrograde protein transport, ER to cytosol +namespace: biological_process +def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744] +synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0030971 +name: receptor tyrosine kinase binding +namespace: molecular_function +def: "Interacting selectively with a receptor that possesses protein tyrosine kinase activity." [GOC:mah] +synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0030972 +name: cleavage of cytosolic proteins during apoptosis +namespace: biological_process +def: "The proteolytic degradation of proteins in the cytosol during apoptosis." [GOC:mah, ISBN:0815332181] +synonym: "apoptotic cleavage of cytosolic proteins" EXACT [] +is_a: GO:0006921 ! cell structure disassembly during apoptosis + +[Term] +id: GO:0030973 +name: molybdate ion binding +namespace: molecular_function +def: "Interacting selectively with molybdate (MoO4 2-) ions." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0030974 +name: thiamin pyrophosphate transport +namespace: biological_process +def: "The directed movement of thiamin pyrophosphate into, out of, within or between cells." [GOC:mlg] +synonym: "thiamin diphosphate transport" EXACT [] +synonym: "thiamine diphosphate transport" EXACT [] +synonym: "thiamine pyrophosphate transport" EXACT [] +synonym: "TPP transport" EXACT [] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0030975 +name: thiamin binding +namespace: molecular_function +def: "Interacting selectively with thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] +synonym: "thiamine binding" EXACT [] +synonym: "vitamin B1 binding" EXACT [] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0030976 +name: thiamin pyrophosphate binding +namespace: molecular_function +def: "Interacting selectively with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg, http://cancerweb.ncl.ac.uk/] +synonym: "aneurine pyrophosphate binding" EXACT [] +synonym: "cocarboxylase binding" EXACT [] +synonym: "diphosphothiamin binding" EXACT [] +synonym: "thiamine pyrophosphate binding" EXACT [] +synonym: "TPP binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0030977 +name: taurine binding +namespace: molecular_function +def: "Interacting selectively with taurine." [GOC:mlg] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0030978 +name: alpha-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] +subset: gosubset_prok +synonym: "alpha-glucan metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process + +[Term] +id: GO:0030979 +name: alpha-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-glucans." [GOC:mah] +synonym: "alpha-glucan anabolism" EXACT [] +synonym: "alpha-glucan biosynthesis" EXACT [] +synonym: "alpha-glucan formation" EXACT [] +synonym: "alpha-glucan synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0030978 ! alpha-glucan metabolic process +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0030980 +name: alpha-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah] +subset: gosubset_prok +synonym: "alpha-glucan breakdown" EXACT [] +synonym: "alpha-glucan catabolism" EXACT [] +synonym: "alpha-glucan degradation" EXACT [] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0030981 +name: cortical microtubule cytoskeleton +namespace: cellular_component +def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] +is_a: GO:0030863 ! cortical cytoskeleton +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0030982 +name: adventurous gliding motility +namespace: biological_process +def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173] +subset: gosubset_prok +synonym: "adventurous gliding movement" EXACT [] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0030983 +name: mismatched DNA binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing one or more mismatches." [GOC:mah] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0030984 +name: kininogen binding +namespace: molecular_function +def: "Interacting selectively with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030985 +name: high molecular weight kininogen binding +namespace: molecular_function +def: "Interacting selectively with a kininogen of high molecular mass." [GOC:mah, PMID:9520414] +synonym: "HK binding" EXACT [] +synonym: "HMW kininogen binding" EXACT [] +is_a: GO:0030984 ! kininogen binding + +[Term] +id: GO:0030986 +name: low molecular weight kininogen binding +namespace: molecular_function +def: "Interacting selectively with a kininogen of low molecular mass." [GOC:mah, PMID:9520414] +synonym: "LK binding" EXACT [] +synonym: "LMW kininogen binding" EXACT [] +is_a: GO:0030984 ! kininogen binding + +[Term] +id: GO:0030987 +name: high molecular weight kininogen receptor binding +namespace: molecular_function +def: "Interacting selectively with a high molecular weight kininogen receptor." [GOC:mah] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0030988 +name: high molecular weight kininogen receptor complex +namespace: cellular_component +def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0030989 +name: horsetail nuclear movement +namespace: biological_process +def: "The cell cycle process whereby oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, which may facilitate synapsis necessary for efficient meiotic recombination; as observed in S. pombe." [PMID:16111942, PMID:9572142] +synonym: "HNM" EXACT [] +synonym: "horsetail movement" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0030473 ! nuclear migration along microtubule +relationship: part_of GO:0007126 ! meiosis + +[Term] +id: GO:0030990 +name: intraflagellar transport particle +namespace: cellular_component +def: "A nonmembrane-bound oliogmeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:kmv, PMID:14570576] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0030991 +name: intraflagellar transport particle A +namespace: cellular_component +def: "The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:kmv, PMID:14570576] +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part +relationship: part_of GO:0030990 ! intraflagellar transport particle + +[Term] +id: GO:0030992 +name: intraflagellar transport particle B +namespace: cellular_component +def: "The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:kmv, PMID:14570576] +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part +relationship: part_of GO:0030990 ! intraflagellar transport particle + +[Term] +id: GO:0030993 +name: axonemal heterotrimeric kinesin-II complex +namespace: cellular_component +def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576] +is_a: GO:0043234 ! protein complex +is_a: GO:0044447 ! axoneme part + +[Term] +id: GO:0030994 +name: primary cell septum disassembly +namespace: biological_process +def: "Dissolution of the primary septum during cell separation." [PMID:12665550] +synonym: "hydrolysis of primary cell septum" EXACT [] +synonym: "primary cell septum hydrolysis" EXACT [] +synonym: "primary septum hydrolysis" BROAD [] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000920 ! cell separation during cytokinesis + +[Term] +id: GO:0030995 +name: cell septum edging catabolic process +namespace: biological_process +def: "Dissolution of the septum edging during cell separation." [PMID:15194814] +synonym: "cell septum edging hydrolysis" EXACT [] +synonym: "hydrolysis of cell septum edging" EXACT [] +synonym: "hydrolysis of edging of cell septum" EXACT [] +synonym: "septum edging hydrolysis" BROAD [] +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0044248 ! cellular catabolic process +relationship: part_of GO:0000920 ! cell separation during cytokinesis + +[Term] +id: GO:0030996 +name: cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0006995 ! cellular response to nitrogen starvation +is_a: GO:0007050 ! cell cycle arrest + +[Term] +id: GO:0030997 +name: regulation of centriole-centriole cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: part_of GO:0007098 ! centrosome cycle +relationship: regulates GO:0010457 ! centriole-centriole cohesion + +[Term] +id: GO:0030998 +name: linear element +namespace: cellular_component +def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [GOC:jb] +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0030999 +name: linear element formation +namespace: biological_process +def: "The cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is formed in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007129 ! synapsis + +[Term] +id: GO:0031000 +name: response to caffeine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] +is_a: GO:0014074 ! response to purine +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0031001 +name: response to brefeldin A +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] +is_a: GO:0046677 ! response to antibiotic + +[Term] +id: GO:0031002 +name: actin rod +namespace: cellular_component +def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0031003 +name: actin tubule +namespace: cellular_component +def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0031002 ! actin rod + +[Term] +id: GO:0031004 +name: potassium ion-transporting ATPase complex +namespace: cellular_component +def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497] +synonym: "Kdp system complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0031005 +name: filamin binding +namespace: molecular_function +def: "Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031006 +name: filamin-A binding +namespace: molecular_function +def: "Interacting selectively with filamin-A." [GOC:mah, PMID:11336782] +synonym: "ABP-280 binding" NARROW [] +synonym: "alpha-filamin binding" NARROW [] +synonym: "filamin A binding" EXACT [] +synonym: "filamin-1 binding" NARROW [] +is_a: GO:0031005 ! filamin binding + +[Term] +id: GO:0031007 +name: filamin-B binding +namespace: molecular_function +def: "Interacting selectively with filamin-B." [GOC:mah, PMID:11336782] +synonym: "ABP-278/276 binding" NARROW [] +synonym: "beta-filamin binding" NARROW [] +synonym: "filamin B binding" EXACT [] +synonym: "filamin-3 binding" NARROW [] +is_a: GO:0031005 ! filamin binding + +[Term] +id: GO:0031008 +name: filamin-C binding +namespace: molecular_function +def: "Interacting selectively with filamin-C, a filamin isoform that contains an 81 amino acid insertion in repeat 20, not present in filamin-A or -B." [GOC:mah, PMID:11336782] +synonym: "ABPL binding" NARROW [] +synonym: "filamin C binding" EXACT [] +synonym: "filamin-2 binding" NARROW [] +synonym: "gamma-filamin binding" NARROW [] +is_a: GO:0031005 ! filamin binding + +[Term] +id: GO:0031009 +name: plastid ADPG pyrophosphorylase complex +namespace: cellular_component +def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah] +is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0031010 +name: ISWI complex +namespace: cellular_component +def: "Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family." [GOC:mah, PMID:15020051] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0031011 +name: INO80 complex +namespace: cellular_component +def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh] +synonym: "INO80 chromatin remodeling complex" EXACT [] +is_a: GO:0016585 ! chromatin remodeling complex +is_a: GO:0033202 ! DNA helicase complex + +[Term] +id: GO:0031012 +name: extracellular matrix +namespace: cellular_component +def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants)." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0031013 +name: troponin I binding +namespace: molecular_function +def: "Interacting selectively with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031014 +name: troponin T binding +namespace: molecular_function +def: "Interacting selectively with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031015 +name: karyopherin docking complex +namespace: cellular_component +def: "A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357] +synonym: "Asm4p-containing complex" NARROW [] +synonym: "nuclear pore subcomplex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0031016 +name: pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0031017 +name: exocrine pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0031016 ! pancreas development +relationship: part_of GO:0035272 ! exocrine system development + +[Term] +id: GO:0031018 +name: endocrine pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0031016 ! pancreas development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0031019 +name: mitochondrial mRNA editing complex +namespace: cellular_component +def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607] +synonym: "mitochondrial editosome" EXACT [] +is_a: GO:0045293 ! mRNA editing complex + +[Term] +id: GO:0031020 +name: plastid mRNA editing complex +namespace: cellular_component +def: "An mRNA editing complex found in a plastid." [GOC:mah] +synonym: "plastid editosome" EXACT [] +is_a: GO:0045293 ! mRNA editing complex + +[Term] +id: GO:0031021 +name: interphase microtubule organizing center +namespace: cellular_component +def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790] +synonym: "iMTOC" EXACT [] +synonym: "interphase microtubule organising center" EXACT [] +synonym: "interphase MTOC" EXACT [] +is_a: GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0031022 +name: nuclear migration along microfilament +namespace: biological_process +def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] +synonym: "nuclear migration, microfilament-mediated" EXACT [] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0030048 ! actin filament-based movement + +[Term] +id: GO:0031023 +name: microtubule organizing center organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "microtubule organising center organization and biogenesis" EXACT [] +synonym: "microtubule organizing center organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031024 +name: interphase microtubule organizing center formation +namespace: biological_process +def: "The assembly of gamma-tubulin and other proteins into an interphase microtubule organizing center." [PMID:15068790] +synonym: "interphase microtubule organising center biosynthesis" EXACT [] +synonym: "interphase microtubule organising center formation" EXACT [] +synonym: "interphase microtubule organizing center assembly" EXACT [] +synonym: "interphase microtubule organizing center biogenesis" EXACT [] +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0031025 +name: equatorial microtubule organizing center disassembly +namespace: biological_process +def: "The process by which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790] +synonym: "equatorial microtubule organising center disassembly" EXACT [] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0031121 ! equatorial microtubule organization + +[Term] +id: GO:0031026 +name: glutamate synthase complex +namespace: cellular_component +def: "A complex that possesses glutamate synthase activity." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031027 +name: glutamate synthase complex (NADH) +namespace: cellular_component +def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] +is_a: GO:0031026 ! glutamate synthase complex + +[Term] +id: GO:0031028 +name: septation initiation signaling +namespace: biological_process +def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007] +synonym: "septation initiation network" EXACT [] +synonym: "septation initiation signalling" EXACT [] +synonym: "SIN" EXACT [] +is_a: GO:0007096 ! regulation of exit from mitosis +is_a: GO:0007265 ! Ras protein signal transduction +is_a: GO:0031991 ! regulation of contractile ring contraction involved in cytokinesis +relationship: part_of GO:0000917 ! barrier septum formation + +[Term] +id: GO:0031029 +name: regulation of septation initiation signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah] +synonym: "regulation of septation initiation network" EXACT [] +synonym: "regulation of septation initiation signalling" EXACT [] +is_a: GO:0032955 ! regulation of barrier septum formation +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0031030 +name: negative regulation of septation initiation signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah] +synonym: "down regulation of septation initiation signaling" EXACT [] +synonym: "down-regulation of septation initiation signaling" EXACT [] +synonym: "downregulation of septation initiation signaling" EXACT [] +synonym: "inhibition of septation initiation signaling" NARROW [] +synonym: "negative regulation of septation initiation network" EXACT [] +synonym: "negative regulation of septation initiation signalling" EXACT [] +is_a: GO:0031029 ! regulation of septation initiation signaling +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0031031 +name: positive regulation of septation initiation signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah] +synonym: "activation of septation initiation signaling" NARROW [] +synonym: "positive regulation of septation initiation network" EXACT [] +synonym: "positive regulation of septation initiation signalling" EXACT [] +synonym: "stimulation of septation initiation signaling" NARROW [] +synonym: "up regulation of septation initiation signaling" EXACT [] +synonym: "up-regulation of septation initiation signaling" EXACT [] +synonym: "upregulation of septation initiation signaling" EXACT [] +is_a: GO:0031029 ! regulation of septation initiation signaling +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0031032 +name: actomyosin structure organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] +comment: Note that this concept is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. +synonym: "actomyosin organization" EXACT [] +synonym: "actomyosin structure organisation and biogenesis" EXACT [] +synonym: "actomyosin structure organization and biogenesis>" EXACT [] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0031033 +name: myosin filament assembly or disassembly +namespace: biological_process +def: "The formation or disassembly of a filament composed of myosin molecules." [GOC:mah] +comment: Note that this concept is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. +synonym: "myosin polymerization or depolymerization" RELATED [] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0031034 +name: myosin filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah] +synonym: "myosin polymerization" RELATED [] +is_a: GO:0006461 ! protein complex assembly +is_a: GO:0031033 ! myosin filament assembly or disassembly + +[Term] +id: GO:0031035 +name: myosin filament disassembly +namespace: biological_process +def: "The disassembly of a filament composed of myosin molecules." [GOC:mah] +synonym: "myosin depolymerization" RELATED [] +is_a: GO:0031033 ! myosin filament assembly or disassembly +is_a: GO:0043624 ! cellular protein complex disassembly + +[Term] +id: GO:0031036 +name: myosin II filament assembly +namespace: biological_process +def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah] +synonym: "myosin II polymerization" RELATED [] +is_a: GO:0031034 ! myosin filament assembly +is_a: GO:0031038 ! myosin II filament assembly or disassembly + +[Term] +id: GO:0031037 +name: myosin II filament disassembly +namespace: biological_process +def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] +synonym: "myosin II depolymerization" RELATED [] +is_a: GO:0031035 ! myosin filament disassembly +is_a: GO:0031038 ! myosin II filament assembly or disassembly + +[Term] +id: GO:0031038 +name: myosin II filament assembly or disassembly +namespace: biological_process +def: "The formation or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] +synonym: "myosin II polymerization or depolymerization" RELATED [] +is_a: GO:0031033 ! myosin filament assembly or disassembly + +[Term] +id: GO:0031039 +name: macronucleus +namespace: cellular_component +def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0031040 +name: micronucleus +namespace: cellular_component +def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0031041 +name: O-glycan processing, core 5 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-1->3-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031042 +name: O-glycan processing, core 6 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-1->6-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031043 +name: O-glycan processing, core 7 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-1->6-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031044 +name: O-glycan processing, core 8 +namespace: biological_process +def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-1->3-GalNAc." [GOC:mah, PMID:10580130] +subset: gosubset_prok +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031045 +name: dense core granule +namespace: cellular_component +def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [PMID:14690495] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0031046 +name: spindle pole body duplication in cytoplasm +namespace: biological_process +def: "Construction of a new spindle pole body adjacent to the existing spindle pole body exterior to the outer nuclear envelope." [GOC:clt] +synonym: "spindle pole body duplication (sensu Schizosaccharomyces)" EXACT [] +is_a: GO:0030474 ! spindle pole body duplication + +[Term] +id: GO:0031047 +name: gene silencing by RNA +namespace: biological_process +def: "Any process by which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] +synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0016458 ! gene silencing + +[Term] +id: GO:0031048 +name: chromatin silencing by small RNA +namespace: biological_process +def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns] +synonym: "RNA interference-like chromatin silencing" EXACT [] +synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb] +synonym: "RNA-mediated TGS" BROAD [] +synonym: "RNA-mediated transcriptional silencing" EXACT [] +synonym: "RNAi-like chromatin silencing" EXACT [] +synonym: "small RNA-mediated heterochromatic silencing" EXACT [] +synonym: "small RNA-mediated heterochromatin biosynthesis" EXACT [] +synonym: "small RNA-mediated heterochromatin formation" EXACT [] +is_a: GO:0006342 ! chromatin silencing +is_a: GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0031049 +name: programmed DNA elimination +namespace: biological_process +def: "The DNA metabolic process by which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] +subset: goslim_pir +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0031050 +name: dsRNA fragmentation +namespace: biological_process +def: "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns] +synonym: "double-stranded RNA fragmentation" EXACT [] +is_a: GO:0006396 ! RNA processing +is_a: GO:0043331 ! response to dsRNA + +[Term] +id: GO:0031051 +name: scnRNA production +namespace: biological_process +def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465] +is_a: GO:0031050 ! dsRNA fragmentation +relationship: part_of GO:0031049 ! programmed DNA elimination + +[Term] +id: GO:0031052 +name: chromosome breakage +namespace: biological_process +def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] +comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0031049 ! programmed DNA elimination + +[Term] +id: GO:0031053 +name: primary microRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [PMID:15211354] +synonym: "pri-miRNA processing" EXACT [] +synonym: "primary miRNA processing" EXACT [] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0035196 ! gene silencing by miRNA, production of miRNAs + +[Term] +id: GO:0031054 +name: pre-microRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [PMID:15211354] +synonym: "pre-miRNA processing" EXACT [] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0035196 ! gene silencing by miRNA, production of miRNAs + +[Term] +id: GO:0031055 +name: chromatin remodeling at centromere +namespace: biological_process +def: "Dynamic structural changes in centromeric DNA." [GOC:mah] +is_a: GO:0006338 ! chromatin remodeling + +[Term] +id: GO:0031056 +name: regulation of histone modification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0016570 ! histone modification + +[Term] +id: GO:0031057 +name: negative regulation of histone modification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] +synonym: "down regulation of histone modification" EXACT [] +synonym: "down-regulation of histone modification" EXACT [] +synonym: "downregulation of histone modification" EXACT [] +synonym: "inhibition of histone modification" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0016570 ! histone modification + +[Term] +id: GO:0031058 +name: positive regulation of histone modification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] +synonym: "activation of histone modification" NARROW [] +synonym: "stimulation of histone modification" NARROW [] +synonym: "up regulation of histone modification" EXACT [] +synonym: "up-regulation of histone modification" EXACT [] +synonym: "upregulation of histone modification" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0031401 ! positive regulation of protein modification process +relationship: positively_regulates GO:0016570 ! histone modification + +[Term] +id: GO:0031059 +name: histone deacetylation at centromere +namespace: biological_process +def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah] +is_a: GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031060 +name: regulation of histone methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] +is_a: GO:0031056 ! regulation of histone modification +relationship: regulates GO:0016571 ! histone methylation + +[Term] +id: GO:0031061 +name: negative regulation of histone methylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] +synonym: "down regulation of histone methylation" EXACT [] +synonym: "down-regulation of histone methylation" EXACT [] +synonym: "downregulation of histone methylation" EXACT [] +synonym: "inhibition of histone methylation" NARROW [] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0031060 ! regulation of histone methylation +relationship: negatively_regulates GO:0016571 ! histone methylation + +[Term] +id: GO:0031062 +name: positive regulation of histone methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] +synonym: "activation of histone methylation" NARROW [] +synonym: "stimulation of histone methylation" NARROW [] +synonym: "up regulation of histone methylation" EXACT [] +synonym: "up-regulation of histone methylation" EXACT [] +synonym: "upregulation of histone methylation" EXACT [] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0031060 ! regulation of histone methylation +relationship: positively_regulates GO:0016571 ! histone methylation + +[Term] +id: GO:0031063 +name: regulation of histone deacetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] +is_a: GO:0031056 ! regulation of histone modification +relationship: regulates GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031064 +name: negative regulation of histone deacetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] +synonym: "down regulation of histone deacetylation" EXACT [] +synonym: "down-regulation of histone deacetylation" EXACT [] +synonym: "downregulation of histone deacetylation" EXACT [] +synonym: "inhibition of histone deacetylation" NARROW [] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0031063 ! regulation of histone deacetylation +relationship: negatively_regulates GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031065 +name: positive regulation of histone deacetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] +synonym: "activation of histone deacetylation" NARROW [] +synonym: "stimulation of histone deacetylation" NARROW [] +synonym: "up regulation of histone deacetylation" EXACT [] +synonym: "up-regulation of histone deacetylation" EXACT [] +synonym: "upregulation of histone deacetylation" EXACT [] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0031063 ! regulation of histone deacetylation +relationship: positively_regulates GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031066 +name: regulation of histone deacetylation at centromere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] +is_a: GO:0031063 ! regulation of histone deacetylation +relationship: regulates GO:0031059 ! histone deacetylation at centromere + +[Term] +id: GO:0031067 +name: negative regulation of histone deacetylation at centromere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah] +synonym: "down regulation of histone deacetylation at centromere" EXACT [] +synonym: "down-regulation of histone deacetylation at centromere" EXACT [] +synonym: "downregulation of histone deacetylation at centromere" EXACT [] +synonym: "inhibition of histone deacetylation at centromere" NARROW [] +is_a: GO:0031064 ! negative regulation of histone deacetylation +is_a: GO:0031066 ! regulation of histone deacetylation at centromere +relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere + +[Term] +id: GO:0031068 +name: positive regulation of histone deacetylation at centromere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] +synonym: "activation of histone deacetylation at centromere" NARROW [] +synonym: "stimulation of histone deacetylation at centromere" NARROW [] +synonym: "up regulation of histone deacetylation at centromere" EXACT [] +synonym: "up-regulation of histone deacetylation at centromere" EXACT [] +synonym: "upregulation of histone deacetylation at centromere" EXACT [] +is_a: GO:0031065 ! positive regulation of histone deacetylation +is_a: GO:0031066 ! regulation of histone deacetylation at centromere +relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere + +[Term] +id: GO:0031069 +name: hair follicle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the hair follicle are generated and organized." [GOC:ln] +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0022405 ! hair cycle process +relationship: part_of GO:0001942 ! hair follicle development +relationship: part_of GO:0048730 ! epidermis morphogenesis + +[Term] +id: GO:0031070 +name: intronic snoRNA processing +namespace: biological_process +def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw] +is_a: GO:0043144 ! snoRNA processing + +[Term] +id: GO:0031071 +name: cysteine desulfurase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] +subset: gosubset_prok +synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7] +synonym: "IscS" RELATED [EC:2.8.1.7] +synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7] +synonym: "NIFS" RELATED [EC:2.8.1.7] +synonym: "NifS" RELATED [EC:2.8.1.7] +synonym: "SufS" RELATED [EC:2.8.1.7] +xref: EC:2.8.1.7 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0031072 +name: heat shock protein binding +namespace: molecular_function +def: "Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031073 +name: cholesterol 26-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499] +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0031074 +name: nucleocytoplasmic shuttling complex +namespace: cellular_component +def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031076 +name: embryonic camera-type eye development +namespace: biological_process +def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] +synonym: "embryonic eye development" EXACT [] +synonym: "embryonic eye development (sensu Actinopterygii)" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009790 ! embryonic development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0031077 +name: post-embryonic camera-type eye development +namespace: biological_process +def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] +synonym: "post-embryonic camera-style eye development" EXACT [] +synonym: "post-embryonic eye development (sensu Actinopterygii)" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009791 ! post-embryonic development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0031078 +name: histone deacetylase activity (H3-K14 specific) +namespace: molecular_function +def: "Catalysis of the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [GOC:mah, PMID:11884604] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0031079 +name: picornain 3C activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28] +comment: This term was made obsolete because it represents a gene product. +synonym: "3C protease activity" EXACT [EC:3.4.22.28] +synonym: "3C proteinase activity" EXACT [EC:3.4.22.28] +synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28] +synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28] +synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28] +synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28] +synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28] +synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "protease 3C" RELATED [EC:3.4.22.28] +synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] +synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] +xref: EC:3.4.22.28 +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0031080 +name: Nup107-160 complex +namespace: cellular_component +def: "A subcomplex of the nuclear pore complex (NPC) mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p." [PMID:10747086, PMID:11823431, PMID:15226438] +synonym: "Nup107-120 complex" EXACT [] +synonym: "Nup84 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0031081 +name: nuclear pore distribution +namespace: biological_process +def: "Any process that establish the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah] +synonym: "positioning of nuclear pores" RELATED [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0051664 ! nuclear pore localization + +[Term] +id: GO:0031082 +name: BLOC complex +namespace: cellular_component +def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0031083 +name: BLOC-1 complex +namespace: cellular_component +def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] +is_a: GO:0031082 ! BLOC complex + +[Term] +id: GO:0031084 +name: BLOC-2 complex +namespace: cellular_component +def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569] +is_a: GO:0031082 ! BLOC complex + +[Term] +id: GO:0031085 +name: BLOC-3 complex +namespace: cellular_component +def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] +is_a: GO:0031082 ! BLOC complex + +[Term] +id: GO:0031086 +name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay +namespace: biological_process +def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] +synonym: "deadenylation-independent mRNA decay" EXACT [] +synonym: "deadenylylation-independent mRNA decay" EXACT [] +synonym: "mRNA breakdown, deadenylation-independent decay" EXACT [] +synonym: "mRNA catabolic process, deadenylation-independent" EXACT [] +synonym: "mRNA catabolic process, deadenylylation-independent" EXACT [] +synonym: "mRNA catabolism, deadenylation-independent" EXACT [] +synonym: "mRNA catabolism, deadenylation-independent decay" EXACT [] +synonym: "mRNA catabolism, deadenylylation-independent" EXACT [] +synonym: "mRNA degradation, deadenylation-independent decay" EXACT [] +synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0031087 +name: deadenylation-independent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] +synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED [] +synonym: "deadenylylation-independent decapping" EXACT [] +is_a: GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay + +[Term] +id: GO:0031088 +name: platelet dense granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042827 ! platelet dense granule + +[Term] +id: GO:0031089 +name: platelet dense granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0042827 ! platelet dense granule + +[Term] +id: GO:0031090 +name: organelle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an organelle." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016020 ! membrane +is_a: GO:0044422 ! organelle part +relationship: part_of GO:0043227 ! membrane-bounded organelle + +[Term] +id: GO:0031091 +name: platelet alpha granule +namespace: cellular_component +def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233] +synonym: "platelet alpha-granule" EXACT [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0031092 +name: platelet alpha granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233] +synonym: "platelet alpha-granule membrane" EXACT [] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0031091 ! platelet alpha granule + +[Term] +id: GO:0031093 +name: platelet alpha granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233] +synonym: "platelet alpha-granule lumen" EXACT [] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0031091 ! platelet alpha granule + +[Term] +id: GO:0031094 +name: platelet dense tubular network +namespace: cellular_component +def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0031095 +name: platelet dense tubular network membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0031094 ! platelet dense tubular network + +[Term] +id: GO:0031096 +name: platelet dense tubular network lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0031094 ! platelet dense tubular network + +[Term] +id: GO:0031097 +name: medial ring +namespace: cellular_component +def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning." [GOC:vw, PMID:15572668] +synonym: "medial cortex" RELATED [] +is_a: GO:0032155 ! cell division site part +is_a: GO:0044448 ! cell cortex part + +[Term] +id: GO:0031098 +name: stress-activated protein kinase signaling pathway +namespace: biological_process +def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah] +synonym: "JNK signaling pathway" NARROW [] +synonym: "JNK signalling pathway" NARROW [] +synonym: "SAPK signaling pathway" EXACT [] +synonym: "SAPK signalling pathway" EXACT [] +synonym: "stress-activated protein kinase signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0031099 +name: regeneration +namespace: biological_process +def: "The regrowth of a lost or destroyed body part, such as an organ or tissue." [GOC:mah] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0031100 +name: organ regeneration +namespace: biological_process +def: "The regrowth of a lost or destroyed organ." [GOC:mah] +is_a: GO:0009887 ! organ morphogenesis +is_a: GO:0031099 ! regeneration + +[Term] +id: GO:0031101 +name: fin regeneration +namespace: biological_process +def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh] +is_a: GO:0033334 ! fin morphogenesis +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0031102 +name: neurite regeneration +namespace: biological_process +def: "The regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:dgh] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0031103 +name: axon regeneration +namespace: biological_process +def: "The regrowth of axons following their loss or damage." [GOC:dgh] +is_a: GO:0007409 ! axonogenesis +is_a: GO:0031102 ! neurite regeneration +is_a: GO:0048678 ! response to axon injury + +[Term] +id: GO:0031104 +name: dendrite regeneration +namespace: biological_process +def: "The regrowth of dendrites following their loss or damage." [GOC:dgh] +is_a: GO:0031102 ! neurite regeneration +is_a: GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0031105 +name: septin complex +namespace: cellular_component +def: "Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0032156 ! septin cytoskeleton + +[Term] +id: GO:0031106 +name: septin ring organization +namespace: biological_process +def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah] +subset: gosubset_prok +synonym: "septin ring organisation" EXACT [] +is_a: GO:0032185 ! septin cytoskeleton organization + +[Term] +id: GO:0031107 +name: septin ring disassembly +namespace: biological_process +def: "The controlled breakdown of a septin ring." [GOC:mah] +is_a: GO:0022411 ! cellular component disassembly +relationship: part_of GO:0031106 ! septin ring organization + +[Term] +id: GO:0031108 +name: holo-[acyl-carrier-protein] biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg] +synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT [] +synonym: "holo-[acyl-carrier-protein] anabolism" EXACT [] +synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT [] +synonym: "holo-[acyl-carrier-protein] formation" EXACT [] +synonym: "holo-[acyl-carrier-protein] synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0031109 +name: microtubule polymerization or depolymerization +namespace: biological_process +def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031110 +name: regulation of microtubule polymerization or depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization + +[Term] +id: GO:0031111 +name: negative regulation of microtubule polymerization or depolymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] +synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization + +[Term] +id: GO:0031112 +name: positive regulation of microtubule polymerization or depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] +synonym: "activation of microtubule polymerization or depolymerization" NARROW [] +synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] +synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization + +[Term] +id: GO:0031113 +name: regulation of microtubule polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0032271 ! regulation of protein polymerization +relationship: regulates GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0031114 +name: regulation of microtubule depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] +synonym: "regulation of microtubule disassembly" EXACT [] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0043244 ! regulation of protein complex disassembly +relationship: regulates GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0031115 +name: negative regulation of microtubule polymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] +synonym: "down regulation of microtubule polymerization" EXACT [] +synonym: "down-regulation of microtubule polymerization" EXACT [] +synonym: "downregulation of microtubule polymerization" EXACT [] +synonym: "inhibition of microtubule polymerization" NARROW [] +is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization +is_a: GO:0031113 ! regulation of microtubule polymerization +is_a: GO:0032272 ! negative regulation of protein polymerization +relationship: negatively_regulates GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0031116 +name: positive regulation of microtubule polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] +synonym: "activation of microtubule polymerization" NARROW [] +synonym: "stimulation of microtubule polymerization" NARROW [] +synonym: "up regulation of microtubule polymerization" EXACT [] +synonym: "up-regulation of microtubule polymerization" EXACT [] +synonym: "upregulation of microtubule polymerization" EXACT [] +is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization +is_a: GO:0031113 ! regulation of microtubule polymerization +is_a: GO:0032273 ! positive regulation of protein polymerization +relationship: positively_regulates GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0031117 +name: positive regulation of microtubule depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] +synonym: "activation of microtubule depolymerization" NARROW [] +synonym: "microtubule destabilization" EXACT [] +synonym: "positive regulation of microtubule disassembly" EXACT [] +synonym: "stimulation of microtubule depolymerization" NARROW [] +synonym: "up regulation of microtubule depolymerization" EXACT [] +synonym: "up-regulation of microtubule depolymerization" EXACT [] +synonym: "upregulation of microtubule depolymerization" EXACT [] +is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization +is_a: GO:0031114 ! regulation of microtubule depolymerization +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0043243 ! positive regulation of protein complex disassembly +relationship: positively_regulates GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0031118 +name: rRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah] +is_a: GO:0000154 ! rRNA modification +is_a: GO:0001522 ! pseudouridine synthesis + +[Term] +id: GO:0031119 +name: tRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah] +is_a: GO:0001522 ! pseudouridine synthesis +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0031120 +name: snRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah] +is_a: GO:0001522 ! pseudouridine synthesis +is_a: GO:0040031 ! snRNA modification + +[Term] +id: GO:0031121 +name: equatorial microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw] +synonym: "equatorial microtubule organisation and biogenesis" EXACT [] +synonym: "equatorial microtubule organization and biogenesis" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031122 +name: cytoplasmic microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] +synonym: "cytoplasmic microtubule organisation and biogenesis" EXACT [] +synonym: "cytoplasmic microtubule organization and biogenesis" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031123 +name: RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah] +subset: gosubset_prok +synonym: "RNA 3' end processing" EXACT [] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0031124 +name: mRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] +subset: gosubset_prok +synonym: "mRNA 3' end processing" EXACT [] +is_a: GO:0006397 ! mRNA processing +is_a: GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0031125 +name: rRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah] +synonym: "rRNA 3' end processing" EXACT [] +is_a: GO:0006364 ! rRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0031126 +name: snoRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah] +synonym: "snoRNA 3' end processing" EXACT [] +is_a: GO:0043144 ! snoRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0031127 +name: alpha(1,2)-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,2)-linkage." [GOC:mah] +subset: gosubset_prok +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0031128 +name: induction +namespace: biological_process +def: "Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other." [GOC:mah] +is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment + +[Term] +id: GO:0031129 +name: inductive cell-cell signaling +namespace: biological_process +def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah] +synonym: "inductive cell-cell signalling" EXACT [] +is_a: GO:0031128 ! induction + +[Term] +id: GO:0031130 +name: creation of an inductive signal +namespace: biological_process +def: "The process by which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah] +is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0031129 ! inductive cell-cell signaling + +[Term] +id: GO:0031131 +name: reception of an inductive signal +namespace: biological_process +def: "The process by which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah] +is_a: GO:0031668 ! cellular response to extracellular stimulus +relationship: part_of GO:0031129 ! inductive cell-cell signaling + +[Term] +id: GO:0031132 +name: serine 3-dehydrogenase +namespace: molecular_function +def: "L-serine + NADP+ = 2-ammoniomalonate semialdehyde + NADPH + H+." [EC:1.1.1.276] +synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276] +xref: EC:1.1.1.276 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0031133 +name: regulation of axon diameter +namespace: biological_process +def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0032536 ! regulation of cell projection size +is_a: GO:0050770 ! regulation of axonogenesis + +[Term] +id: GO:0031134 +name: sister chromatid biorientation +namespace: biological_process +def: "The cell cycle process whereby sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] +synonym: "chromosome biorientation" EXACT [] +synonym: "sister kinetochore biorientation" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051313 ! attachment of spindle microtubules to chromosome +relationship: part_of GO:0007080 ! mitotic metaphase plate congression + +[Term] +id: GO:0031135 +name: negative regulation of conjugation +namespace: biological_process +def: "Any process that decreases the rate of conjugation." [GOC:mah] +synonym: "down regulation of conjugation" EXACT [] +synonym: "down-regulation of conjugation" EXACT [] +synonym: "downregulation of conjugation" EXACT [] +synonym: "inhibition of conjugation" NARROW [] +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0046999 ! regulation of conjugation +relationship: negatively_regulates GO:0000746 ! conjugation + +[Term] +id: GO:0031136 +name: positive regulation of conjugation +namespace: biological_process +def: "Any process that increases the rate or frequency of conjugation." [GOC:mah] +synonym: "activation of conjugation" NARROW [] +synonym: "stimulation of conjugation" NARROW [] +synonym: "up regulation of conjugation" EXACT [] +synonym: "up-regulation of conjugation" EXACT [] +synonym: "upregulation of conjugation" EXACT [] +is_a: GO:0043902 ! positive regulation of multi-organism process +is_a: GO:0046999 ! regulation of conjugation +relationship: positively_regulates GO:0000746 ! conjugation + +[Term] +id: GO:0031137 +name: regulation of conjugation with cellular fusion +namespace: biological_process +def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah] +is_a: GO:0046999 ! regulation of conjugation +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0031138 +name: negative regulation of conjugation with cellular fusion +namespace: biological_process +def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah] +synonym: "down regulation of conjugation with cellular fusion" EXACT [] +synonym: "down-regulation of conjugation with cellular fusion" EXACT [] +synonym: "downregulation of conjugation with cellular fusion" EXACT [] +synonym: "inhibition of conjugation with cellular fusion" NARROW [] +is_a: GO:0031135 ! negative regulation of conjugation +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0031139 +name: positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah] +synonym: "activation of conjugation with cellular fusion" NARROW [] +synonym: "stimulation of conjugation with cellular fusion" NARROW [] +synonym: "up regulation of conjugation with cellular fusion" EXACT [] +synonym: "up-regulation of conjugation with cellular fusion" EXACT [] +synonym: "upregulation of conjugation with cellular fusion" EXACT [] +is_a: GO:0031136 ! positive regulation of conjugation +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0031140 +name: induction of conjugation upon nutrient starvation +namespace: biological_process +def: "The process by which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah] +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0031141 +name: induction of conjugation upon carbon starvation +namespace: biological_process +def: "The process by which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah] +is_a: GO:0031140 ! induction of conjugation upon nutrient starvation + +[Term] +id: GO:0031142 +name: induction of conjugation upon nitrogen starvation +namespace: biological_process +def: "The process by which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah] +is_a: GO:0006995 ! cellular response to nitrogen starvation +is_a: GO:0031140 ! induction of conjugation upon nutrient starvation + +[Term] +id: GO:0031143 +name: pseudopodium +namespace: cellular_component +def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +synonym: "pseudopod" EXACT [] +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0031144 +name: proteasome localization +namespace: biological_process +def: "Any process by which the proteasome is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of proteasome localization" EXACT [] +is_a: GO:0034629 ! cellular protein complex localization + +[Term] +id: GO:0031145 +name: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] +synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] +xref: Reactome:174048 +xref: Reactome:174143 +xref: Reactome:174154 +xref: Reactome:174178 +xref: Reactome:174184 +xref: Reactome:211658 +xref: Reactome:211660 +xref: Reactome:211662 +xref: Reactome:211671 +xref: Reactome:211995 +xref: Reactome:221430 +xref: Reactome:221432 +xref: Reactome:221434 +xref: Reactome:221442 +xref: Reactome:221759 +xref: Reactome:230062 +xref: Reactome:230064 +xref: Reactome:230066 +xref: Reactome:230073 +xref: Reactome:230340 +xref: Reactome:238082 +xref: Reactome:238083 +xref: Reactome:238086 +xref: Reactome:238094 +xref: Reactome:238376 +xref: Reactome:244691 +xref: Reactome:244693 +xref: Reactome:244695 +xref: Reactome:244756 +xref: Reactome:244931 +xref: Reactome:249841 +xref: Reactome:252573 +xref: Reactome:255754 +xref: Reactome:259147 +xref: Reactome:262361 +xref: Reactome:262450 +xref: Reactome:262505 +xref: Reactome:265285 +xref: Reactome:265335 +xref: Reactome:268297 +xref: Reactome:268406 +xref: Reactome:268459 +xref: Reactome:273979 +xref: Reactome:273980 +xref: Reactome:273983 +xref: Reactome:274031 +xref: Reactome:274158 +xref: Reactome:280458 +xref: Reactome:280459 +xref: Reactome:280462 +xref: Reactome:280509 +xref: Reactome:280631 +xref: Reactome:282891 +xref: Reactome:286480 +xref: Reactome:286482 +xref: Reactome:286528 +xref: Reactome:286530 +xref: Reactome:286650 +is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0031146 +name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083] +synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] +synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] +is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0031147 +name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT [] +synonym: "DIF-1 metabolic process" EXACT [] +synonym: "DIF-1 metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process + +[Term] +id: GO:0031148 +name: DIF-1 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT [] +synonym: "DIF-1 biosynthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process + +[Term] +id: GO:0031149 +name: sorocarp stalk cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "stalk cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0031150 ! sorocarp stalk development + +[Term] +id: GO:0031150 +name: sorocarp stalk development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein." [DDB_REF:5048 "DictyBase paper repository", GOC:mtg_sensu, ISBN:0521583640] +synonym: "sorophore development" EXACT [] +synonym: "stalk development (sensu Dictyosteliida)" EXACT [] +synonym: "stalk formation (sensu Dictyosteliida)" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0031154 ! culmination during sorocarp development + +[Term] +id: GO:0031151 +name: histone lysine N-methyltransferase activity (H3-K79 specific) +namespace: molecular_function +def: "Catalysis of the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0031152 +name: aggregation involved in sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "aggregate development involved in sorocarp development" EXACT [] +synonym: "aggregation during fruiting body development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031153 +name: slug development during sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development takes place during sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "migratory slug development during sorocarp development" NARROW [] +synonym: "pseudoplasmodium biosynthesis" EXACT [] +synonym: "pseudoplasmodium formation" EXACT [] +synonym: "slug development during fruiting body development" EXACT [] +synonym: "standing slug development during sorocarp development" NARROW [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031154 +name: culmination during sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Clumination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "culminant development" EXACT [] +synonym: "culmination during fruiting body development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031155 +name: regulation of fruiting body development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fruiting body development." [GOC:mah] +synonym: "regulation of fruiting body formation" EXACT [] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0030582 ! fruiting body development + +[Term] +id: GO:0031156 +name: regulation of sorocarp development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sorocarp development." [DDB_REF:2530 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu] +synonym: "regulation of fruiting body development (sensu Dictyosteliida)" EXACT [] +synonym: "regulation of fruiting body formation (sensu Dictyosteliida)" EXACT [] +is_a: GO:0031155 ! regulation of fruiting body development +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: regulates GO:0030587 ! sorocarp development + +[Term] +id: GO:0031157 +name: regulation of aggregate size involved in sorocarp development +namespace: biological_process +def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, GOC:pg] +synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED [] +synonym: "regulation of aggregation during fruiting body formation" RELATED [] +is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0031158 +name: negative regulation of aggregate size involved in sorocarp development +namespace: biological_process +def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, GOC:pg] +synonym: "down regulation of aggregate size" EXACT [] +synonym: "down-regulation of aggregate size" EXACT [] +synonym: "downregulation of aggregate size" EXACT [] +synonym: "inhibition of aggregate size" NARROW [] +is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development + +[Term] +id: GO:0031159 +name: positive regulation of aggregate size involved in sorocarp development +namespace: biological_process +def: "Any process that increases the size of the aggregate formed during sorocarp formation." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:pg] +synonym: "activation of aggregate size" NARROW [] +synonym: "stimulation of aggregate size" NARROW [] +synonym: "up regulation of aggregate size" EXACT [] +synonym: "up-regulation of aggregate size" EXACT [] +synonym: "upregulation of aggregate size" EXACT [] +is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development + +[Term] +id: GO:0031160 +name: spore wall +namespace: cellular_component +def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] +synonym: "spore coat" EXACT [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0031161 +name: phosphatidylinositol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah] +synonym: "phosphatidylinositol breakdown" EXACT [] +synonym: "phosphatidylinositol catabolism" EXACT [] +synonym: "phosphatidylinositol degradation" EXACT [] +synonym: "PtdIns catabolic process" EXACT [] +synonym: "PtdIns catabolism" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:0031162 +name: sulfur incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] +synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly + +[Term] +id: GO:0031163 +name: metallo-sulfur cluster assembly +namespace: biological_process +def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] +subset: gosubset_prok +synonym: "metallo-sulfur cluster biosynthesis" EXACT [] +synonym: "metallo-sulphur cluster assembly" EXACT [] +is_a: GO:0051188 ! cofactor biosynthetic process + +[Term] +id: GO:0031164 +name: contractile vacuolar membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0000331 ! contractile vacuole + +[Term] +id: GO:0031165 +name: integral to contractile vacuolar membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:pg] +is_a: GO:0031166 ! integral to vacuolar membrane +is_a: GO:0031311 ! intrinsic to contractile vacuolar membrane + +[Term] +id: GO:0031166 +name: integral to vacuolar membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031301 ! integral to organelle membrane +is_a: GO:0031310 ! intrinsic to vacuolar membrane + +[Term] +id: GO:0031167 +name: rRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah] +is_a: GO:0000154 ! rRNA modification +is_a: GO:0001510 ! RNA methylation + +[Term] +id: GO:0031168 +name: ferrichrome metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ferrichrome metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0031169 +name: ferrichrome biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ferrichrome anabolism" EXACT [] +synonym: "ferrichrome biosynthesis" EXACT [] +synonym: "ferrichrome formation" EXACT [] +synonym: "ferrichrome synthesis" EXACT [] +is_a: GO:0019539 ! siderophore biosynthetic process from hydroxamic acid +is_a: GO:0031168 ! ferrichrome metabolic process + +[Term] +id: GO:0031170 +name: ferricrocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] +synonym: "ferricrocin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0031171 +name: ferricrocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] +synonym: "ferricrocin anabolism" EXACT [] +synonym: "ferricrocin biosynthesis" EXACT [] +synonym: "ferricrocin formation" EXACT [] +synonym: "ferricrocin synthesis" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0031170 ! ferricrocin metabolic process + +[Term] +id: GO:0031172 +name: ornithine N5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine + O2 + donor-H2 = N5-hydroxy-L-ornithine + acceptor + H2O." [GOC:mah, PMID:12828635] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0031173 +name: otolith mineralization completed early in development +namespace: biological_process +def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] +synonym: "otoconia mineralization" EXACT [] +synonym: "otoconium mineralization" EXACT [] +synonym: "otolith mineralization (sensu Tetrapoda)" RELATED [] +is_a: GO:0045299 ! otolith mineralization + +[Term] +id: GO:0031174 +name: lifelong otolith mineralization +namespace: biological_process +def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873] +synonym: "otolith mineralization (sensu Actinopterygii)" EXACT [] +is_a: GO:0045299 ! otolith mineralization + +[Term] +id: GO:0031175 +name: neurite development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neurite over time, from its formation to the mature structure. The neurite is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] +synonym: "neurite biosynthesis" NARROW [] +synonym: "neurite formation" NARROW [] +synonym: "neurite growth" NARROW [] +is_a: GO:0030030 ! cell projection organization +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0031176 +name: endo-1,4-beta-xylanase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8] +synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] +synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] +synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] +synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] +synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8] +synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8] +synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] +synonym: "endo-1,4-b-xylanase activity" EXACT [] +synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8] +synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8] +synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] +synonym: "xylanase" BROAD [EC:3.2.1.8] +xref: EC:3.2.1.8 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0031177 +name: phosphopantetheine binding +namespace: molecular_function +def: "Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [ChEBI:16858, GOC:mah] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0031178 +name: siderophore biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of a siderophore; occurs by non-ribosomal peptide synthesis." [GOC:mah, PMID:12040125] +synonym: "siderophore anabolism, peptide biosynthesis" EXACT [] +synonym: "siderophore anabolism, peptide formation" EXACT [] +synonym: "siderophore formation, peptide biosynthesis" EXACT [] +synonym: "siderophore formation, peptide formation" EXACT [] +synonym: "siderophore synthesis, peptide biosynthesis" EXACT [] +synonym: "siderophore synthesis, peptide formation" EXACT [] +is_a: GO:0019184 ! nonribosomal peptide biosynthetic process +relationship: part_of GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0031179 +name: peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0043412 ! biopolymer modification + +[Term] +id: GO:0031180 +name: siderophore biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a siderophore. Includes the formation of heterocycles such as thiazoline rings and oxazoline rings." [GOC:mah, PMID:12040125] +synonym: "siderophore anabolism, peptide modification" EXACT [] +synonym: "siderophore formation, peptide modification" EXACT [] +synonym: "siderophore synthesis, peptide modification" EXACT [] +is_a: GO:0031179 ! peptide modification +relationship: part_of GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0031181 +name: achromobactin biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore achromobactin." [GOC:mah, PMID:12040125] +synonym: "achromobactin anabolism, peptide biosynthesis" EXACT [] +synonym: "achromobactin anabolism, peptide formation" EXACT [] +synonym: "achromobactin formation, peptide biosynthesis" EXACT [] +synonym: "achromobactin formation, peptide formation" EXACT [] +synonym: "achromobactin synthesis, peptide biosynthesis" EXACT [] +synonym: "achromobactin synthesis, peptide formation" EXACT [] +is_a: GO:0031178 ! siderophore biosynthetic process, peptide formation +relationship: part_of GO:0042861 ! achromobactin biosynthetic process + +[Term] +id: GO:0031182 +name: achromobactin biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore achromobactin." [GOC:mah, PMID:12040125] +synonym: "achromobactin anabolism, peptide modification" EXACT [] +synonym: "achromobactin formation, peptide modification" EXACT [] +synonym: "achromobactin synthesis, peptide modification" EXACT [] +is_a: GO:0031180 ! siderophore biosynthetic process, peptide modification +relationship: part_of GO:0042861 ! achromobactin biosynthetic process + +[Term] +id: GO:0031183 +name: chrysobactin biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore chrysobactin." [GOC:mah, PMID:12040125] +synonym: "chrysobactin anabolism, peptide biosynthesis" EXACT [] +synonym: "chrysobactin anabolism, peptide formation" EXACT [] +synonym: "chrysobactin formation, peptide biosynthesis" EXACT [] +synonym: "chrysobactin formation, peptide formation" EXACT [] +synonym: "chrysobactin synthesis, peptide biosynthesis" EXACT [] +synonym: "chrysobactin synthesis, peptide formation" EXACT [] +is_a: GO:0031178 ! siderophore biosynthetic process, peptide formation +relationship: part_of GO:0042858 ! chrysobactin biosynthetic process + +[Term] +id: GO:0031184 +name: chrysobactin biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore chrysobactin." [GOC:mah, PMID:12040125] +synonym: "chrysobactin anabolism, peptide modification" EXACT [] +synonym: "chrysobactin formation, peptide modification" EXACT [] +synonym: "chrysobactin synthesis, peptide modification" EXACT [] +is_a: GO:0031180 ! siderophore biosynthetic process, peptide modification +relationship: part_of GO:0042858 ! chrysobactin biosynthetic process + +[Term] +id: GO:0031185 +name: ferricrocin biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore ferricrocin." [GOC:mah, PMID:12040125] +synonym: "ferricrocin anabolism, peptide biosynthesis" EXACT [] +synonym: "ferricrocin anabolism, peptide formation" EXACT [] +synonym: "ferricrocin formation, peptide biosynthesis" EXACT [] +synonym: "ferricrocin formation, peptide formation" EXACT [] +synonym: "ferricrocin synthesis, peptide biosynthesis" EXACT [] +synonym: "ferricrocin synthesis, peptide formation" EXACT [] +is_a: GO:0031178 ! siderophore biosynthetic process, peptide formation +relationship: part_of GO:0031171 ! ferricrocin biosynthetic process + +[Term] +id: GO:0031186 +name: ferricrocin biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore ferricrocin." [GOC:mah, PMID:12040125] +synonym: "ferricrocin anabolism, peptide modification" EXACT [] +synonym: "ferricrocin formation, peptide modification" EXACT [] +synonym: "ferricrocin synthesis, peptide modification" EXACT [] +is_a: GO:0031180 ! siderophore biosynthetic process, peptide modification +relationship: part_of GO:0031171 ! ferricrocin biosynthetic process + +[Term] +id: GO:0031187 +name: pyochelin biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore pyochelin." [GOC:mah, PMID:12040125] +synonym: "pyochelin anabolism, peptide biosynthesis" EXACT [] +synonym: "pyochelin anabolism, peptide formation" EXACT [] +synonym: "pyochelin formation, peptide biosynthesis" EXACT [] +synonym: "pyochelin formation, peptide formation" EXACT [] +synonym: "pyochelin synthesis, peptide biosynthesis" EXACT [] +synonym: "pyochelin synthesis, peptide formation" EXACT [] +is_a: GO:0031178 ! siderophore biosynthetic process, peptide formation +relationship: part_of GO:0042864 ! pyochelin biosynthetic process + +[Term] +id: GO:0031188 +name: pyochelin biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore pyochelin." [GOC:mah, PMID:12040125] +synonym: "pyochelin anabolism, peptide modification" EXACT [] +synonym: "pyochelin formation, peptide modification" EXACT [] +synonym: "pyochelin synthesis, peptide modification" EXACT [] +is_a: GO:0031180 ! siderophore biosynthetic process, peptide modification +relationship: part_of GO:0042864 ! pyochelin biosynthetic process + +[Term] +id: GO:0031189 +name: siderophore biosynthetic process from catechol, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of a catechol-derived siderophore." [GOC:mah, PMID:12040125] +synonym: "siderophore anabolism from catechol, peptide biosynthesis" EXACT [] +synonym: "siderophore anabolism from catechol, peptide formation" EXACT [] +synonym: "siderophore formation from catechol, peptide biosynthesis" EXACT [] +synonym: "siderophore formation from catechol, peptide formation" EXACT [] +synonym: "siderophore synthesis from catechol, peptide biosynthesis" EXACT [] +synonym: "siderophore synthesis from catechol, peptide formation" EXACT [] +is_a: GO:0031178 ! siderophore biosynthetic process, peptide formation +relationship: part_of GO:0019540 ! siderophore biosynthetic process from catechol + +[Term] +id: GO:0031190 +name: siderophore biosynthetic process from catechol, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a catechol-derived siderophore." [GOC:mah, PMID:12040125] +synonym: "siderophore anabolism from catechol, peptide modification" EXACT [] +synonym: "siderophore formation from catechol, peptide modification" EXACT [] +synonym: "siderophore synthesis from catechol, peptide modification" EXACT [] +is_a: GO:0031180 ! siderophore biosynthetic process, peptide modification +relationship: part_of GO:0019540 ! siderophore biosynthetic process from catechol + +[Term] +id: GO:0031191 +name: enterobactin biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore enterobactin." [GOC:mah, PMID:12040125] +synonym: "enterobactin anabolism, peptide biosynthesis" EXACT [] +synonym: "enterobactin anabolism, peptide formation" EXACT [] +synonym: "enterobactin formation, peptide biosynthesis" EXACT [] +synonym: "enterobactin formation, peptide formation" EXACT [] +synonym: "enterobactin synthesis, peptide biosynthesis" EXACT [] +synonym: "enterobactin synthesis, peptide formation" EXACT [] +is_a: GO:0031189 ! siderophore biosynthetic process from catechol, peptide formation +relationship: part_of GO:0009239 ! enterobactin biosynthetic process + +[Term] +id: GO:0031192 +name: enterobactin biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore enterobactin during the chemical reactions and pathways resulting in the formation of enterobactin." [GOC:mah, PMID:12040125] +synonym: "enterobactin anabolism, peptide modification" EXACT [] +synonym: "enterobactin formation, peptide modification" EXACT [] +synonym: "enterobactin synthesis, peptide modification" EXACT [] +is_a: GO:0031190 ! siderophore biosynthetic process from catechol, peptide modification +relationship: part_of GO:0009239 ! enterobactin biosynthetic process + +[Term] +id: GO:0031193 +name: rhizobactin 1021 biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore rhizobactin." [GOC:mah, PMID:12040125] +synonym: "rhizobactin 1021 anabolism, peptide biosynthesis" EXACT [] +synonym: "rhizobactin 1021 anabolism, peptide formation" EXACT [] +synonym: "rhizobactin 1021 formation, peptide biosynthesis" EXACT [] +synonym: "rhizobactin 1021 formation, peptide formation" EXACT [] +synonym: "rhizobactin 1021 synthesis, peptide biosynthesis" EXACT [] +synonym: "rhizobactin 1021 synthesis, peptide formation" EXACT [] +is_a: GO:0031189 ! siderophore biosynthetic process from catechol, peptide formation +relationship: part_of GO:0019289 ! rhizobactin 1021 biosynthetic process + +[Term] +id: GO:0031194 +name: rhizobactin 1021 biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore rhizobactin during the chemical reactions and pathways resulting in the formation of rhizobactin." [GOC:mah, PMID:12040125] +synonym: "rhizobactin 1021 anabolism, peptide modification" EXACT [] +synonym: "rhizobactin 1021 formation, peptide modification" EXACT [] +synonym: "rhizobactin 1021 synthesis, peptide modification" EXACT [] +is_a: GO:0031190 ! siderophore biosynthetic process from catechol, peptide modification +relationship: part_of GO:0019289 ! rhizobactin 1021 biosynthetic process + +[Term] +id: GO:0031195 +name: vibriobactin biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of the siderophore vibriobactin." [GOC:mah, PMID:12040125] +synonym: "vibriobactin anabolism, peptide biosynthesis" EXACT [] +synonym: "vibriobactin anabolism, peptide formation" EXACT [] +synonym: "vibriobactin formation, peptide biosynthesis" EXACT [] +synonym: "vibriobactin formation, peptide formation" EXACT [] +synonym: "vibriobactin synthesis, peptide biosynthesis" EXACT [] +synonym: "vibriobactin synthesis, peptide formation" EXACT [] +is_a: GO:0031189 ! siderophore biosynthetic process from catechol, peptide formation +relationship: part_of GO:0019537 ! vibriobactin biosynthetic process + +[Term] +id: GO:0031196 +name: vibriobactin biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the siderophore vibriobactin during the chemical reactions and pathways resulting in the formation of vibriobactin." [GOC:mah, PMID:12040125] +synonym: "vibriobactin anabolism, peptide modification" EXACT [] +synonym: "vibriobactin formation, peptide modification" EXACT [] +synonym: "vibriobactin synthesis, peptide modification" EXACT [] +is_a: GO:0031190 ! siderophore biosynthetic process from catechol, peptide modification +relationship: part_of GO:0019537 ! vibriobactin biosynthetic process + +[Term] +id: GO:0031197 +name: siderophore biosynthetic process from hydroxamic acid, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of a hydroxamic acid-derived siderophore." [GOC:mah, PMID:12040125] +synonym: "siderophore anabolism from hydroxamic acid, peptide biosynthesis" EXACT [] +synonym: "siderophore anabolism from hydroxamic acid, peptide formation" EXACT [] +synonym: "siderophore formation from hydroxamic acid, peptide biosynthesis" EXACT [] +synonym: "siderophore formation from hydroxamic acid, peptide formation" EXACT [] +synonym: "siderophore synthesis from hydroxamic acid, peptide biosynthesis" EXACT [] +synonym: "siderophore synthesis from hydroxamic acid, peptide formation" EXACT [] +is_a: GO:0031178 ! siderophore biosynthetic process, peptide formation +relationship: part_of GO:0019539 ! siderophore biosynthetic process from hydroxamic acid + +[Term] +id: GO:0031198 +name: siderophore biosynthetic process from hydroxamic acid, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a hydroxamic acid-derived siderophore." [GOC:mah, PMID:12040125] +synonym: "siderophore anabolism from hydroxamic acid, peptide modification" EXACT [] +synonym: "siderophore formation from hydroxamic acid, peptide modification" EXACT [] +synonym: "siderophore synthesis from hydroxamic acid, peptide modification" EXACT [] +is_a: GO:0031180 ! siderophore biosynthetic process, peptide modification +relationship: part_of GO:0019539 ! siderophore biosynthetic process from hydroxamic acid + +[Term] +id: GO:0031199 +name: ferrichrome biosynthetic process, peptide formation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide backbone of a ferrichrome, a type of siderophore." [GOC:mah, PMID:12040125] +synonym: "ferrichrome anabolism, peptide biosynthesis" EXACT [] +synonym: "ferrichrome anabolism, peptide formation" EXACT [] +synonym: "ferrichrome formation, peptide biosynthesis" EXACT [] +synonym: "ferrichrome formation, peptide formation" EXACT [] +synonym: "ferrichrome synthesis, peptide biosynthesis" EXACT [] +synonym: "ferrichrome synthesis, peptide formation" EXACT [] +is_a: GO:0031197 ! siderophore biosynthetic process from hydroxamic acid, peptide formation +relationship: part_of GO:0031169 ! ferrichrome biosynthetic process + +[Term] +id: GO:0031200 +name: ferrichrome biosynthetic process, peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a ferrichrome, a type of siderophore." [GOC:mah, PMID:12040125] +synonym: "ferrichrome anabolism, peptide modification" EXACT [] +synonym: "ferrichrome formation, peptide modification" EXACT [] +synonym: "ferrichrome synthesis, peptide modification" EXACT [] +is_a: GO:0031198 ! siderophore biosynthetic process from hydroxamic acid, peptide modification +relationship: part_of GO:0031169 ! ferrichrome biosynthetic process + +[Term] +id: GO:0031201 +name: SNARE complex +namespace: cellular_component +def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [PMID:10872468] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0031202 +name: RNA splicing factor activity, transesterification mechanism +namespace: molecular_function +alt_id: GO:0000385 +def: "An activity which assists splicing of substrate RNA(s) by facilitating the formation and stabilization of a series of catalytic conformations in which key RNA sequences are positioned for a series of two transesterification reactions which result in removal of the intron sequence and joining of two exons." [GOC:krc] +comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. +synonym: "pre-mRNA splicing factor activity" RELATED [] +synonym: "spliceosomal catalysis" EXACT [] +xref: Reactome:160901 +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0031203 +name: posttranslational protein targeting to membrane, docking +namespace: biological_process +def: "The process by which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814] +synonym: "posttranslational protein membrane targeting, docking" EXACT [] +synonym: "protein docking during posttranslational protein targeting to membrane" EXACT [] +synonym: "Sec-translated protein complex assembly" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane + +[Term] +id: GO:0031204 +name: posttranslational protein targeting to membrane, translocation +namespace: biological_process +def: "The process by which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814] +synonym: "posttranslational protein membrane targeting, translocation" EXACT [] +synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT [] +is_a: GO:0065002 ! intracellular protein transmembrane transport +relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane + +[Term] +id: GO:0031205 +name: endoplasmic reticulum Sec complex +namespace: cellular_component +def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809] +subset: goslim_pir +synonym: "Sec complex (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0031206 +name: Sec complex-associated translocon complex +namespace: cellular_component +def: "A translocon complex physically associated with a Sec complex." [GOC:mah, PMID:12518317, PMID:14617809] +is_a: GO:0005784 ! translocon complex +relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex + +[Term] +id: GO:0031207 +name: Sec62/Sec63 complex +namespace: cellular_component +def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809] +synonym: "ER protein translocation subcomplex " EXACT [] +synonym: "Sec62/63 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex + +[Term] +id: GO:0031208 +name: POZ domain binding +namespace: molecular_function +def: "Interacting selectively with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0031209 +name: SCAR complex +namespace: cellular_component +def: "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570] +synonym: "WAVE complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0031210 +name: phosphatidylcholine binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0031211 +name: palmitoyltransferase complex +namespace: cellular_component +def: "A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0031213 +name: RSF complex +namespace: cellular_component +def: "A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1)." [PMID:12972596] +synonym: "remodeling and spacing factor complex " EXACT [] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0031214 +name: biomineral formation +namespace: biological_process +def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736] +synonym: "biomineralization" EXACT [] +synonym: "mineralization" EXACT [] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0031215 +name: shell calcification +namespace: biological_process +def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736] +is_a: GO:0031214 ! biomineral formation + +[Term] +id: GO:0031216 +name: neopullulanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of pullulan to panose (6-a-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg] +synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135] +synonym: "pullulanase II activity" EXACT [] +xref: EC:3.2.1.135 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0031217 +name: glucan 1,4-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,4-linkages in 1,4-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg] +synonym: "1,4-beta-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.74] +synonym: "beta-1,4-beta-glucanase activity" EXACT [EC:3.2.1.74] +synonym: "beta-1,4-glucanase activity" EXACT [] +synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74] +synonym: "exo-1,4-beta-glucanase activity" EXACT [] +synonym: "exo-1,4-beta-glucosidase activity" EXACT [] +synonym: "exo-beta-1,4-glucanase activity" EXACT [] +synonym: "exo-beta-1,4-glucosidase activity" EXACT [] +synonym: "exocellulase activity" EXACT [] +xref: EC:3.2.1.74 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0031218 +name: arabinogalactan endo-1,4-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg] +synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89] +synonym: "arabinogalactanase activity" EXACT [] +synonym: "endo-1,4-beta-galactanase activity" EXACT [] +synonym: "galactanase activity" EXACT [] +xref: EC:3.2.1.89 +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0031219 +name: levanase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg] +synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65] +synonym: "levan hydrolase activity" EXACT [] +xref: EC:3.2.1.65 +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0031220 +name: maltodextrin phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0031221 +name: arabinan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabinan, a branched homopolymer of L-arabinose." [GOC:mlg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "arabinan metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0031222 +name: arabinan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a branched homopolymer of L-arabinose." [GOC:mlg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "arabinan breakdown" EXACT [] +synonym: "arabinan catabolism" EXACT [] +synonym: "arabinan degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0031221 ! arabinan metabolic process + +[Term] +id: GO:0031223 +name: auditory behavior +namespace: biological_process +def: "The actions or reactions of an organism in response to a sound." [GOC:rc] +synonym: "auditory behaviour" EXACT [] +synonym: "behavioral response to sound" EXACT [] +synonym: "behavioural response to sound" EXACT [] +is_a: GO:0007638 ! mechanosensory behavior + +[Term] +id: GO:0031224 +name: intrinsic to membrane +namespace: cellular_component +def: "Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. +subset: gosubset_prok +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0031225 +name: anchored to membrane +namespace: cellular_component +def: "Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane." [GOC:mah] +is_a: GO:0031224 ! intrinsic to membrane + +[Term] +id: GO:0031226 +name: intrinsic to plasma membrane +namespace: cellular_component +def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031224 ! intrinsic to membrane +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0031227 +name: intrinsic to endoplasmic reticulum membrane +namespace: cellular_component +def: "Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0031228 +name: intrinsic to Golgi membrane +namespace: cellular_component +def: "Located in the Golgi membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0000139 ! Golgi membrane + +[Term] +id: GO:0031229 +name: intrinsic to nuclear inner membrane +namespace: cellular_component +def: "Located in the nuclear inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044453 ! nuclear membrane part +relationship: part_of GO:0005637 ! nuclear inner membrane + +[Term] +id: GO:0031230 +name: intrinsic to cell outer membrane +namespace: cellular_component +def: "Located in the cell outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "intrinsic to outer membrane (sensu Gram-negative Bacteria)" EXACT [] +synonym: "intrinsic to outer membrane (sensu Proteobacteria)" EXACT [] +is_a: GO:0031224 ! intrinsic to membrane +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031231 +name: intrinsic to peroxisomal membrane +namespace: cellular_component +def: "Located in the peroxisomal membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044439 ! peroxisomal part +relationship: part_of GO:0005778 ! peroxisomal membrane + +[Term] +id: GO:0031232 +name: extrinsic to external side of plasma membrane +namespace: cellular_component +def: "Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0019897 ! extrinsic to plasma membrane +relationship: part_of GO:0009897 ! external side of plasma membrane + +[Term] +id: GO:0031233 +name: intrinsic to external side of plasma membrane +namespace: cellular_component +def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah] +is_a: GO:0031226 ! intrinsic to plasma membrane +relationship: part_of GO:0009897 ! external side of plasma membrane + +[Term] +id: GO:0031234 +name: extrinsic to internal side of plasma membrane +namespace: cellular_component +def: "Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0019897 ! extrinsic to plasma membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0009898 ! internal side of plasma membrane + +[Term] +id: GO:0031235 +name: intrinsic to internal side of plasma membrane +namespace: cellular_component +def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm." [GOC:mah] +is_a: GO:0031226 ! intrinsic to plasma membrane +relationship: part_of GO:0009898 ! internal side of plasma membrane + +[Term] +id: GO:0031236 +name: extrinsic to external side of plasma membrane, in periplasmic space +namespace: cellular_component +alt_id: GO:0031238 +def: "Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "extrinsic to external side of plasma membrane, in periplasmic space (sensu Gram-negative Bacteria)" EXACT [] +synonym: "extrinsic to external side of plasma membrane, in periplasmic space (sensu Proteobacteria)" EXACT [] +is_a: GO:0031232 ! extrinsic to external side of plasma membrane +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0030288 ! outer membrane-bounded periplasmic space + +[Term] +id: GO:0031237 +name: intrinsic to external side of plasma membrane, in periplasmic space +namespace: cellular_component +alt_id: GO:0031239 +def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "intrinsic to external side of plasma membrane, in periplasmic space (sensu Gram-negative Bacteria)" EXACT [] +synonym: "intrinsic to external side of plasma membrane, in periplasmic space (sensu Proteobacteria)" EXACT [] +is_a: GO:0031233 ! intrinsic to external side of plasma membrane +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0030288 ! outer membrane-bounded periplasmic space + +[Term] +id: GO:0031240 +name: external side of cell outer membrane +namespace: cellular_component +def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "external side of outer membrane" RELATED [] +is_a: GO:0044425 ! membrane part +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031241 +name: internal side of cell outer membrane +namespace: cellular_component +def: "The side of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "internal side of outer membrane" EXACT [] +is_a: GO:0044425 ! membrane part +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031242 +name: extrinsic to external side of cell outer membrane +namespace: cellular_component +def: "Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "extrinsic to external side of outer membrane" EXACT [] +is_a: GO:0031244 ! extrinsic to cell outer membrane +relationship: part_of GO:0031240 ! external side of cell outer membrane + +[Term] +id: GO:0031243 +name: intrinsic to external side of cell outer membrane +namespace: cellular_component +def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "intrinsic to external side of outer membrane" EXACT [] +is_a: GO:0031230 ! intrinsic to cell outer membrane +relationship: part_of GO:0031240 ! external side of cell outer membrane + +[Term] +id: GO:0031244 +name: extrinsic to cell outer membrane +namespace: cellular_component +def: "Loosely bound to one surface of the outer membrane of the cell, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "extrinsic to outer membrane (sensu Gram-negative Bacteria)" EXACT [] +synonym: "extrinsic to outer membrane (sensu Proteobacteria)" EXACT [] +is_a: GO:0019898 ! extrinsic to membrane +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031245 +name: extrinsic to internal side of cell outer membrane +namespace: cellular_component +def: "Loosely bound to the surface of the outer membrane of the cell that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "extrinsic to internal side of outer membrane" EXACT [] +is_a: GO:0031244 ! extrinsic to cell outer membrane +relationship: part_of GO:0031241 ! internal side of cell outer membrane + +[Term] +id: GO:0031246 +name: intrinsic to internal side of cell outer membrane +namespace: cellular_component +def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "intrinsic to internal side of outer membrane" EXACT [] +is_a: GO:0031230 ! intrinsic to cell outer membrane +relationship: part_of GO:0031241 ! internal side of cell outer membrane + +[Term] +id: GO:0031247 +name: actin rod formation +namespace: biological_process +def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0031248 +name: protein acetyltransferase complex +namespace: cellular_component +def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031249 +name: denatured protein binding +namespace: molecular_function +def: "Interacting selectively with denatured proteins." [GOC:mlg] +comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031250 +name: anaerobic ribonucleoside-triphosphate reductase complex +namespace: cellular_component +def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0031251 +name: PAN complex +namespace: cellular_component +def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670] +synonym: "poly(A) nuclease complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0031252 +name: cell leading edge +namespace: cellular_component +def: "The area of a motile cell closest to the direction of movement." [GOC:pg] +subset: goslim_pir +synonym: "front of cell" EXACT [] +synonym: "leading edge of cell" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0031253 +name: cell projection membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a cell surface projection." [GOC:mah] +synonym: "membrane extension" RELATED [] +synonym: "membrane projection" RELATED [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0044463 ! cell projection part + +[Term] +id: GO:0031254 +name: trailing edge +namespace: cellular_component +def: "The area of a motile cell opposite to the direction of movement." [GOC:pg] +subset: goslim_pir +synonym: "back of cell" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0031255 +name: lateral part of motile cell +namespace: cellular_component +def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0031256 +name: leading edge membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0031257 +name: trailing edge membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0031254 ! trailing edge + +[Term] +id: GO:0031258 +name: lamellipodium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031256 ! leading edge membrane +relationship: part_of GO:0030027 ! lamellipodium + +[Term] +id: GO:0031259 +name: uropod membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah] +synonym: "uropodium membrane" EXACT [] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031257 ! trailing edge membrane +relationship: part_of GO:0001931 ! uropod + +[Term] +id: GO:0031260 +name: pseudopodium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0031143 ! pseudopodium + +[Term] +id: GO:0031261 +name: DNA replication preinitiation complex +namespace: cellular_component +def: "A multiprotein complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others." [PMID:12694535, PMID:15194812] +synonym: "pre-IC" EXACT [] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0031262 +name: Ndc80 complex +namespace: cellular_component +def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517] +synonym: "Nuf2-Ndc80 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0031263 +name: amine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg] +subset: gosubset_prok +synonym: "amine ABC transporter" NARROW [] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0031264 +name: death-inducing signaling complex +namespace: cellular_component +def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] +subset: goslim_pir +synonym: "death-inducing signalling complex" EXACT [] +synonym: "DISC" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0031265 +name: CD95 death-inducing signaling complex +namespace: cellular_component +def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] +synonym: "CD95 death-inducing signalling complex" EXACT [] +synonym: "CD95 DISC" EXACT [] +synonym: "Fas death-inducing signaling complex" EXACT [] +is_a: GO:0031264 ! death-inducing signaling complex + +[Term] +id: GO:0031266 +name: TRAIL death-inducing signaling complex +namespace: cellular_component +def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] +synonym: "TRAIL death-inducing signalling complex" EXACT [] +synonym: "TRAIL DISC" EXACT [] +is_a: GO:0031264 ! death-inducing signaling complex + +[Term] +id: GO:0031267 +name: small GTPase binding +namespace: molecular_function +def: "Interacting selectively with a small monomeric GTPase." [GOC:mah] +is_a: GO:0051020 ! GTPase binding + +[Term] +id: GO:0031268 +name: pseudopodium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] +synonym: "pseudopodium organisation and biogenesis" EXACT [] +synonym: "pseudopodium organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0031269 +name: pseudopodium formation +namespace: biological_process +def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:mah, GOC:pg] +synonym: "pseudopodium extension" EXACT [] +is_a: GO:0030031 ! cell projection biogenesis +is_a: GO:0031268 ! pseudopodium organization + +[Term] +id: GO:0031270 +name: pseudopodium retraction +namespace: biological_process +def: "The myosin-based contraction and retraction of the pseudopodium." [GOC:pg] +is_a: GO:0031268 ! pseudopodium organization + +[Term] +id: GO:0031271 +name: lateral pseudopodium formation +namespace: biological_process +def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:mah, GOC:pg] +is_a: GO:0031269 ! pseudopodium formation + +[Term] +id: GO:0031272 +name: regulation of pseudopodium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0031269 ! pseudopodium formation + +[Term] +id: GO:0031273 +name: negative regulation of pseudopodium formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] +synonym: "down regulation of pseudopodium formation" EXACT [] +synonym: "down-regulation of pseudopodium formation" EXACT [] +synonym: "downregulation of pseudopodium formation" EXACT [] +synonym: "inhibition of pseudopodium formation" NARROW [] +is_a: GO:0031272 ! regulation of pseudopodium formation +is_a: GO:0031345 ! negative regulation of cell projection organization +relationship: negatively_regulates GO:0031269 ! pseudopodium formation + +[Term] +id: GO:0031274 +name: positive regulation of pseudopodium formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] +synonym: "activation of pseudopodium formation" NARROW [] +synonym: "stimulation of pseudopodium formation" NARROW [] +synonym: "up regulation of pseudopodium formation" EXACT [] +synonym: "up-regulation of pseudopodium formation" EXACT [] +synonym: "upregulation of pseudopodium formation" EXACT [] +is_a: GO:0031272 ! regulation of pseudopodium formation +is_a: GO:0031346 ! positive regulation of cell projection organization +relationship: positively_regulates GO:0031269 ! pseudopodium formation + +[Term] +id: GO:0031275 +name: regulation of lateral pseudopodium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:pg] +is_a: GO:0031272 ! regulation of pseudopodium formation +relationship: regulates GO:0031271 ! lateral pseudopodium formation + +[Term] +id: GO:0031276 +name: negative regulation of lateral pseudopodium formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:pg] +synonym: "down regulation of lateral pseudopodium formation" EXACT [] +synonym: "down-regulation of lateral pseudopodium formation" EXACT [] +synonym: "downregulation of lateral pseudopodium formation" EXACT [] +synonym: "inhibition of lateral pseudopodium formation" NARROW [] +is_a: GO:0031273 ! negative regulation of pseudopodium formation +is_a: GO:0031275 ! regulation of lateral pseudopodium formation +relationship: negatively_regulates GO:0031271 ! lateral pseudopodium formation + +[Term] +id: GO:0031277 +name: positive regulation of lateral pseudopodium formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:pg] +synonym: "activation of lateral pseudopodium formation" NARROW [] +synonym: "stimulation of lateral pseudopodium formation" NARROW [] +synonym: "up regulation of lateral pseudopodium formation" EXACT [] +synonym: "up-regulation of lateral pseudopodium formation" EXACT [] +synonym: "upregulation of lateral pseudopodium formation" EXACT [] +is_a: GO:0031274 ! positive regulation of pseudopodium formation +is_a: GO:0031275 ! regulation of lateral pseudopodium formation +relationship: positively_regulates GO:0031271 ! lateral pseudopodium formation + +[Term] +id: GO:0031278 +name: alpha-1,2-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655] +xref: EC:2.4.1.- +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0031279 +name: regulation of cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah] +subset: gosubset_prok +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0031280 +name: negative regulation of cyclase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah] +synonym: "down regulation of cyclase activity" EXACT [] +synonym: "down-regulation of cyclase activity" EXACT [] +synonym: "downregulation of cyclase activity" EXACT [] +synonym: "inhibition of cyclase activity" NARROW [] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0043086 ! negative regulation of catalytic activity + +[Term] +id: GO:0031281 +name: positive regulation of cyclase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a cyclase." [GOC:mah] +synonym: "activation of cyclase activity" NARROW [] +synonym: "stimulation of cyclase activity" NARROW [] +synonym: "up regulation of cyclase activity" EXACT [] +synonym: "up-regulation of cyclase activity" EXACT [] +synonym: "upregulation of cyclase activity" EXACT [] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0043085 ! positive regulation of catalytic activity + +[Term] +id: GO:0031282 +name: regulation of guanylate cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0031283 +name: negative regulation of guanylate cyclase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] +synonym: "down regulation of guanylate cyclase activity" EXACT [] +synonym: "down-regulation of guanylate cyclase activity" EXACT [] +synonym: "downregulation of guanylate cyclase activity" EXACT [] +synonym: "inhibition of guanylate cyclase activity" NARROW [] +is_a: GO:0031280 ! negative regulation of cyclase activity +is_a: GO:0031282 ! regulation of guanylate cyclase activity +is_a: GO:0051350 ! negative regulation of lyase activity + +[Term] +id: GO:0031284 +name: positive regulation of guanylate cyclase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] +synonym: "activation of guanylate cyclase activity" NARROW [] +synonym: "stimulation of guanylate cyclase activity" NARROW [] +synonym: "up regulation of guanylate cyclase activity" EXACT [] +synonym: "up-regulation of guanylate cyclase activity" EXACT [] +synonym: "upregulation of guanylate cyclase activity" EXACT [] +is_a: GO:0031281 ! positive regulation of cyclase activity +is_a: GO:0031282 ! regulation of guanylate cyclase activity +is_a: GO:0051349 ! positive regulation of lyase activity + +[Term] +id: GO:0031285 +name: regulation of sorocarp stalk cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] +synonym: "regulation of stalk cell differentiation" EXACT [] +is_a: GO:0031156 ! regulation of sorocarp development +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation + +[Term] +id: GO:0031286 +name: negative regulation of sorocarp stalk cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp stalk cell differentiation." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] +synonym: "down regulation of stalk cell differentiation" EXACT [] +synonym: "down-regulation of stalk cell differentiation" EXACT [] +synonym: "downregulation of stalk cell differentiation" EXACT [] +synonym: "inhibition of stalk cell differentiation" NARROW [] +synonym: "negative regulation of stalk cell differentiation" EXACT [] +is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation + +[Term] +id: GO:0031287 +name: positive regulation of sorocarp stalk cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] +synonym: "activation of stalk cell differentiation" NARROW [] +synonym: "positive regulation of stalk cell differentiation" EXACT [] +synonym: "stimulation of stalk cell differentiation" NARROW [] +synonym: "up regulation of stalk cell differentiation" EXACT [] +synonym: "up-regulation of stalk cell differentiation" EXACT [] +synonym: "upregulation of stalk cell differentiation" EXACT [] +is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation +is_a: GO:0032109 ! positive regulation of response to nutrient levels +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation + +[Term] +id: GO:0031288 +name: sorocarp morphogenesis +namespace: biological_process +def: "The process by which the sorocarp is generated and organized. Morphogenesis pertains to the creation of form." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu] +synonym: "fruiting body morphogenesis (sensu Dictyosteliida)" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031289 +name: actin phosphorylation +namespace: biological_process +def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah] +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0030047 ! actin modification + +[Term] +id: GO:0031290 +name: retinal ganglion cell axon guidance +namespace: biological_process +def: "The process by which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] +synonym: "retinal ganglion cell axon pathfinding" EXACT [] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0031291 +name: Ran protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0031292 +name: gene conversion at mating-type locus, DNA double-strand break processing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang." [GOC:mah] +is_a: GO:0000729 ! DNA double-strand break processing +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0031293 +name: membrane protein intracellular domain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018] +synonym: "membrane protein solubilization" RELATED [] +is_a: GO:0033619 ! membrane protein proteolysis + +[Term] +id: GO:0031294 +name: lymphocyte costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "lymphocyte co-stimulation" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0051251 ! positive regulation of lymphocyte activation + +[Term] +id: GO:0031295 +name: T cell costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "T cell co-stimulation" EXACT [] +synonym: "T lymphocyte costimulation" EXACT [] +synonym: "T-cell co-stimulation" EXACT [] +synonym: "T-cell costimulation" EXACT [] +synonym: "T-lymphocyte costimulation" EXACT [] +is_a: GO:0031294 ! lymphocyte costimulation +is_a: GO:0050870 ! positive regulation of T cell activation + +[Term] +id: GO:0031296 +name: B cell costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "B cell co-stimulation " EXACT [] +synonym: "B lymphocyte co-stimulation" EXACT [] +synonym: "B lymphocyte costimulation" EXACT [] +synonym: "B-cell co-stimulation" EXACT [] +synonym: "B-cell costimulation" EXACT [] +synonym: "B-lymphocyte co-stimulation" EXACT [] +synonym: "B-lymphocyte costimulation" EXACT [] +is_a: GO:0031294 ! lymphocyte costimulation +is_a: GO:0050871 ! positive regulation of B cell activation + +[Term] +id: GO:0031297 +name: replication fork processing +namespace: biological_process +def: "The process by which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [PMID:11459955, PMID:15367656, PMID:17660542] +synonym: "collapsed replication fork processing" EXACT [] +synonym: "recovery from replication fork arrest" EXACT [] +synonym: "recovery from replication fork stalling" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0034984 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0031298 +name: replication fork protection complex +namespace: cellular_component +def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656] +synonym: "Swi1-Swi3 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043596 ! nuclear replication fork + +[Term] +id: GO:0031299 +name: taurine-pyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde." [EC:2.6.1.77] +synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77] +synonym: "Tpa" RELATED [EC:2.6.1.77] +xref: EC:2.6.1.77 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0031300 +name: intrinsic to organelle membrane +namespace: cellular_component +def: "Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031224 ! intrinsic to membrane +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0031090 ! organelle membrane + +[Term] +id: GO:0031301 +name: integral to organelle membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0016021 ! integral to membrane +is_a: GO:0031300 ! intrinsic to organelle membrane + +[Term] +id: GO:0031302 +name: intrinsic to endosome membrane +namespace: cellular_component +def: "Located in the endosome membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0031303 +name: integral to endosome membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031301 ! integral to organelle membrane +is_a: GO:0031302 ! intrinsic to endosome membrane + +[Term] +id: GO:0031304 +name: intrinsic to mitochondrial inner membrane +namespace: cellular_component +def: "Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0031305 +name: integral to mitochondrial inner membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031304 ! intrinsic to mitochondrial inner membrane +is_a: GO:0032592 ! integral to mitochondrial membrane + +[Term] +id: GO:0031306 +name: intrinsic to mitochondrial outer membrane +namespace: cellular_component +def: "Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0031307 +name: integral to mitochondrial outer membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031306 ! intrinsic to mitochondrial outer membrane +is_a: GO:0032592 ! integral to mitochondrial membrane + +[Term] +id: GO:0031308 +name: intrinsic to nuclear outer membrane +namespace: cellular_component +def: "Located in the nuclear outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044453 ! nuclear membrane part +relationship: part_of GO:0005640 ! nuclear outer membrane + +[Term] +id: GO:0031309 +name: integral to nuclear outer membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031301 ! integral to organelle membrane +is_a: GO:0031308 ! intrinsic to nuclear outer membrane + +[Term] +id: GO:0031310 +name: intrinsic to vacuolar membrane +namespace: cellular_component +def: "Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0031311 +name: intrinsic to contractile vacuolar membrane +namespace: cellular_component +def: "Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031310 ! intrinsic to vacuolar membrane +relationship: part_of GO:0031164 ! contractile vacuolar membrane + +[Term] +id: GO:0031312 +name: extrinsic to organelle membrane +namespace: cellular_component +def: "Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0019898 ! extrinsic to membrane +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0031090 ! organelle membrane + +[Term] +id: GO:0031313 +name: extrinsic to endosome membrane +namespace: cellular_component +def: "Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0031314 +name: extrinsic to mitochondrial inner membrane +namespace: cellular_component +def: "Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0031315 +name: extrinsic to mitochondrial outer membrane +namespace: cellular_component +def: "Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044455 ! mitochondrial membrane part + +[Term] +id: GO:0031316 +name: extrinsic to nuclear outer membrane +namespace: cellular_component +def: "Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region." [GOC:mah] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044453 ! nuclear membrane part +relationship: part_of GO:0005640 ! nuclear outer membrane + +[Term] +id: GO:0031317 +name: tripartite ATP-independent periplasmic transporter complex +namespace: cellular_component +def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg] +subset: gosubset_prok +synonym: "TRAP transporter complex" EXACT [] +synonym: "TRAP-T transporter complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0031318 +name: detection of folic acid +namespace: biological_process +def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg] +synonym: "detection of folate" EXACT [] +synonym: "folate detection" EXACT [] +synonym: "folate sensing" EXACT [] +synonym: "folic acid detection" EXACT [] +synonym: "folic acid sensing" EXACT [] +is_a: GO:0009594 ! detection of nutrient +is_a: GO:0051593 ! response to folic acid + +[Term] +id: GO:0031319 +name: detection of cAMP +namespace: biological_process +def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg] +synonym: "3',5'-cAMP detection" EXACT [] +synonym: "3',5'-cAMP sensing" EXACT [] +synonym: "cAMP detection" EXACT [] +synonym: "cAMP sensing" EXACT [] +synonym: "cyclic AMP detection" EXACT [] +synonym: "detection of 3',5' cAMP" EXACT [] +synonym: "detection of 3',5'-cAMP" EXACT [] +synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT [] +synonym: "detection of cyclic AMP" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051591 ! response to cAMP + +[Term] +id: GO:0031320 +name: hexitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah] +subset: gosubset_prok +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0031321 +name: ascospore-type prospore formation +namespace: biological_process +def: "During ascospore formation, the process by which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385] +synonym: "forespore formation (sensu Fungi)" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030437 ! ascospore formation + +[Term] +id: GO:0031322 +name: ascospore-type prospore-specific spindle pole body modification +namespace: biological_process +def: "Structural modification of the spindle pole body that takes place during the second meiotic division during ascospore formation; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] +synonym: "forespore specific spindle pole body modification" EXACT [] +synonym: "forespore-specific spindle pole body modification" EXACT [] +synonym: "prospore specific spindle pole body modification" EXACT [] +synonym: "sporulation specific spindle pole body modification " EXACT [] +is_a: GO:0051300 ! spindle pole body organization +relationship: part_of GO:0031321 ! ascospore-type prospore formation + +[Term] +id: GO:0031323 +name: regulation of cellular metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cellular metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0031324 +name: negative regulation of cellular metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cellular metabolic process" EXACT [] +synonym: "down-regulation of cellular metabolic process" EXACT [] +synonym: "downregulation of cellular metabolic process" EXACT [] +synonym: "inhibition of cellular metabolic process" NARROW [] +synonym: "negative regulation of cellular metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0031325 +name: positive regulation of cellular metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cellular metabolic process" NARROW [] +synonym: "positive regulation of cellular metabolism" EXACT [] +synonym: "stimulation of cellular metabolic process" NARROW [] +synonym: "up regulation of cellular metabolic process" EXACT [] +synonym: "up-regulation of cellular metabolic process" EXACT [] +synonym: "upregulation of cellular metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0031326 +name: regulation of cellular biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cellular anabolism" EXACT [] +synonym: "regulation of cellular biosynthesis" EXACT [] +synonym: "regulation of cellular formation" EXACT [] +synonym: "regulation of cellular synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0031327 +name: negative regulation of cellular biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cellular biosynthetic process" EXACT [] +synonym: "down-regulation of cellular biosynthetic process" EXACT [] +synonym: "downregulation of cellular biosynthetic process" EXACT [] +synonym: "inhibition of cellular biosynthetic process" NARROW [] +synonym: "negative regulation of cellular anabolism" EXACT [] +synonym: "negative regulation of cellular biosynthesis" EXACT [] +synonym: "negative regulation of cellular formation" EXACT [] +synonym: "negative regulation of cellular synthesis" EXACT [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0031328 +name: positive regulation of cellular biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cellular biosynthetic process" NARROW [] +synonym: "positive regulation of cellular anabolism" EXACT [] +synonym: "positive regulation of cellular biosynthesis" EXACT [] +synonym: "positive regulation of cellular formation" EXACT [] +synonym: "positive regulation of cellular synthesis" EXACT [] +synonym: "stimulation of cellular biosynthetic process" NARROW [] +synonym: "up regulation of cellular biosynthetic process" EXACT [] +synonym: "up-regulation of cellular biosynthetic process" EXACT [] +synonym: "upregulation of cellular biosynthetic process" EXACT [] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: positively_regulates GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0031329 +name: regulation of cellular catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cellular breakdown" EXACT [] +synonym: "regulation of cellular catabolism" EXACT [] +synonym: "regulation of cellular degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0031330 +name: negative regulation of cellular catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of cellular catabolic process" EXACT [] +synonym: "down-regulation of cellular catabolic process" EXACT [] +synonym: "downregulation of cellular catabolic process" EXACT [] +synonym: "inhibition of cellular catabolic process" NARROW [] +synonym: "negative regulation of cellular breakdown" EXACT [] +synonym: "negative regulation of cellular catabolism" EXACT [] +synonym: "negative regulation of cellular degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: negatively_regulates GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0031331 +name: positive regulation of cellular catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "activation of cellular catabolic process" NARROW [] +synonym: "positive regulation of cellular breakdown" EXACT [] +synonym: "positive regulation of cellular catabolism" EXACT [] +synonym: "positive regulation of cellular degradation" EXACT [] +synonym: "stimulation of cellular catabolic process" NARROW [] +synonym: "up regulation of cellular catabolic process" EXACT [] +synonym: "up-regulation of cellular catabolic process" EXACT [] +synonym: "upregulation of cellular catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: positively_regulates GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0031332 +name: RNAi effector complex +namespace: cellular_component +def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433] +subset: goslim_pir +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0031333 +name: negative regulation of protein complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of protein complex assembly" EXACT [] +synonym: "down-regulation of protein complex assembly" EXACT [] +synonym: "downregulation of protein complex assembly" EXACT [] +synonym: "inhibition of protein complex assembly" NARROW [] +is_a: GO:0043254 ! regulation of protein complex assembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0006461 ! protein complex assembly + +[Term] +id: GO:0031334 +name: positive regulation of protein complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] +subset: gosubset_prok +synonym: "activation of protein complex assembly" NARROW [] +synonym: "stimulation of protein complex assembly" NARROW [] +synonym: "up regulation of protein complex assembly" EXACT [] +synonym: "up-regulation of protein complex assembly" EXACT [] +synonym: "upregulation of protein complex assembly" EXACT [] +is_a: GO:0043254 ! regulation of protein complex assembly +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0006461 ! protein complex assembly + +[Term] +id: GO:0031335 +name: regulation of sulfur amino acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of sulfur amino acid metabolism" EXACT [] +is_a: GO:0006521 ! regulation of amino acid metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: regulates GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0031336 +name: negative regulation of sulfur amino acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "down-regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "downregulation of sulfur amino acid metabolic process" EXACT [] +synonym: "inhibition of sulfur amino acid metabolic process" NARROW [] +synonym: "negative regulation of sulfur amino acid metabolism" EXACT [] +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +is_a: GO:0045763 ! negative regulation of amino acid metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0031337 +name: positive regulation of sulfur amino acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] +subset: gosubset_prok +synonym: "activation of sulfur amino acid metabolic process" NARROW [] +synonym: "positive regulation of sulfur amino acid metabolism" EXACT [] +synonym: "stimulation of sulfur amino acid metabolic process" NARROW [] +synonym: "up regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "up-regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "upregulation of sulfur amino acid metabolic process" EXACT [] +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +is_a: GO:0045764 ! positive regulation of amino acid metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0031338 +name: regulation of vesicle fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0006906 ! vesicle fusion + +[Term] +id: GO:0031339 +name: negative regulation of vesicle fusion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] +synonym: "down regulation of vesicle fusion" EXACT [] +synonym: "down-regulation of vesicle fusion" EXACT [] +synonym: "downregulation of vesicle fusion" EXACT [] +synonym: "inhibition of vesicle fusion" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0006906 ! vesicle fusion + +[Term] +id: GO:0031340 +name: positive regulation of vesicle fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] +synonym: "activation of vesicle fusion" NARROW [] +synonym: "stimulation of vesicle fusion" NARROW [] +synonym: "up regulation of vesicle fusion" EXACT [] +synonym: "up-regulation of vesicle fusion" EXACT [] +synonym: "upregulation of vesicle fusion" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0006906 ! vesicle fusion + +[Term] +id: GO:0031341 +name: regulation of cell killing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell killing, the process by which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0001906 ! cell killing + +[Term] +id: GO:0031342 +name: negative regulation of cell killing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell killing." [GOC:mah] +synonym: "down regulation of cell killing" EXACT [] +synonym: "down-regulation of cell killing" EXACT [] +synonym: "downregulation of cell killing" EXACT [] +synonym: "inhibition of cell killing" NARROW [] +is_a: GO:0031341 ! regulation of cell killing +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0001906 ! cell killing + +[Term] +id: GO:0031343 +name: positive regulation of cell killing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] +synonym: "activation of cell killing" NARROW [] +synonym: "stimulation of cell killing" NARROW [] +synonym: "up regulation of cell killing" EXACT [] +synonym: "up-regulation of cell killing" EXACT [] +synonym: "upregulation of cell killing" EXACT [] +is_a: GO:0031341 ! regulation of cell killing +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0001906 ! cell killing + +[Term] +id: GO:0031344 +name: regulation of cell projection organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cell projection organisation and biogenesis" EXACT [] +synonym: "regulation of cell projection organization and biogenesis" EXACT [] +is_a: GO:0022604 ! regulation of cell morphogenesis +relationship: regulates GO:0030030 ! cell projection organization + +[Term] +id: GO:0031345 +name: negative regulation of cell projection organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] +synonym: "down regulation of cell projection organization and biogenesis" EXACT [] +synonym: "down-regulation of cell projection organization and biogenesis" EXACT [] +synonym: "downregulation of cell projection organization and biogenesis" EXACT [] +synonym: "inhibition of cell projection organization and biogenesis" NARROW [] +synonym: "negative regulation of cell projection organisation and biogenesis" EXACT [] +synonym: "negative regulation of cell projection organization and biogenesis" EXACT [] +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0030030 ! cell projection organization + +[Term] +id: GO:0031346 +name: positive regulation of cell projection organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] +synonym: "activation of cell projection organization and biogenesis" NARROW [] +synonym: "positive regulation of cell projection organisation and biogenesis" EXACT [] +synonym: "positive regulation of cell projection organization and biogenesis" EXACT [] +synonym: "stimulation of cell projection organization and biogenesis" NARROW [] +synonym: "up regulation of cell projection organization and biogenesis" EXACT [] +synonym: "up-regulation of cell projection organization and biogenesis" EXACT [] +synonym: "upregulation of cell projection organization and biogenesis" EXACT [] +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0030030 ! cell projection organization + +[Term] +id: GO:0031347 +name: regulation of defense response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0006952 ! defense response + +[Term] +id: GO:0031348 +name: negative regulation of defense response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a defense response." [GOC:mah] +synonym: "down regulation of defense response" EXACT [] +synonym: "down-regulation of defense response" EXACT [] +synonym: "downregulation of defense response" EXACT [] +synonym: "inhibition of defense response" NARROW [] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0006952 ! defense response + +[Term] +id: GO:0031349 +name: positive regulation of defense response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] +synonym: "activation of defense response" NARROW [] +synonym: "stimulation of defense response" NARROW [] +synonym: "up regulation of defense response" EXACT [] +synonym: "up-regulation of defense response" EXACT [] +synonym: "upregulation of defense response" EXACT [] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0006952 ! defense response + +[Term] +id: GO:0031350 +name: intrinsic to plastid membrane +namespace: cellular_component +def: "Located in a plastid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0042170 ! plastid membrane + +[Term] +id: GO:0031351 +name: integral to plastid membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031301 ! integral to organelle membrane +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0042170 ! plastid membrane + +[Term] +id: GO:0031352 +name: intrinsic to plastid inner membrane +namespace: cellular_component +def: "Located in a plastid inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031350 ! intrinsic to plastid membrane +relationship: part_of GO:0009528 ! plastid inner membrane + +[Term] +id: GO:0031353 +name: integral to plastid inner membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031351 ! integral to plastid membrane +relationship: part_of GO:0009528 ! plastid inner membrane + +[Term] +id: GO:0031354 +name: intrinsic to plastid outer membrane +namespace: cellular_component +def: "Located in a plastid outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031350 ! intrinsic to plastid membrane +relationship: part_of GO:0009527 ! plastid outer membrane + +[Term] +id: GO:0031355 +name: integral to plastid outer membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031351 ! integral to plastid membrane +relationship: part_of GO:0009527 ! plastid outer membrane + +[Term] +id: GO:0031356 +name: intrinsic to chloroplast inner membrane +namespace: cellular_component +def: "Located in the chloroplast inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031352 ! intrinsic to plastid inner membrane +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009706 ! chloroplast inner membrane + +[Term] +id: GO:0031357 +name: integral to chloroplast inner membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031353 ! integral to plastid inner membrane +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009706 ! chloroplast inner membrane + +[Term] +id: GO:0031358 +name: intrinsic to chloroplast outer membrane +namespace: cellular_component +def: "Located in the chloroplast outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031354 ! intrinsic to plastid outer membrane +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0031359 +name: integral to chloroplast outer membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031355 ! integral to plastid outer membrane +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0031360 +name: intrinsic to thylakoid membrane +namespace: cellular_component +def: "Located in a thylakoid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +is_a: GO:0031300 ! intrinsic to organelle membrane +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0042651 ! thylakoid membrane + +[Term] +id: GO:0031361 +name: integral to thylakoid membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031301 ! integral to organelle membrane +is_a: GO:0044436 ! thylakoid part +relationship: part_of GO:0042651 ! thylakoid membrane + +[Term] +id: GO:0031362 +name: anchored to external side of plasma membrane +namespace: cellular_component +def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah] +is_a: GO:0031233 ! intrinsic to external side of plasma membrane +is_a: GO:0046658 ! anchored to plasma membrane + +[Term] +id: GO:0031363 +name: N-terminal protein amino acid deamination +namespace: biological_process +def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0031364 +name: N-terminal protein amino acid deamination, from side chain +namespace: biological_process +def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah] +is_a: GO:0031363 ! N-terminal protein amino acid deamination + +[Term] +id: GO:0031365 +name: N-terminal protein amino acid modification +namespace: biological_process +def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0031366 +name: N-terminal peptidyl-arginine deamination +namespace: biological_process +def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:mah] +is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain + +[Term] +id: GO:0031367 +name: N-terminal peptidyl-glutamine deamination +namespace: biological_process +def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah] +is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain + +[Term] +id: GO:0031368 +name: Pro-X metallocarboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16] +synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16] +synonym: "membrane Pro-Xaa carboxypeptidase" NARROW [] +synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16] +xref: EC:3.4.17.16 +is_obsolete: true +replaced_by: GO:0004181 +replaced_by: GO:0008233 + +[Term] +id: GO:0031369 +name: translation initiation factor binding +namespace: molecular_function +def: "Interacting selectively with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031370 +name: eukaryotic initiation factor 4G binding +namespace: molecular_function +def: "Interacting selectively with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] +synonym: "eIF4G binding" EXACT [] +is_a: GO:0031369 ! translation initiation factor binding + +[Term] +id: GO:0031371 +name: ubiquitin conjugating enzyme complex +namespace: cellular_component +def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah] +subset: goslim_pir +synonym: "E2 complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031372 +name: UBC13-MMS2 complex +namespace: cellular_component +def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086] +is_a: GO:0031371 ! ubiquitin conjugating enzyme complex + +[Term] +id: GO:0031373 +name: cytosolic fatty acid synthase complex +namespace: cellular_component +def: "A fatty acid synthase complex located in the cytosol." [GOC:mah] +synonym: "cytosolic FAS complex" EXACT [] +is_a: GO:0005835 ! fatty acid synthase complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0031374 +name: cytosolic type I fatty acid synthase complex +namespace: cellular_component +def: "A cytosolic fatty acid synthase complex in which each polypeptide chain contains several different catalytic sites." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] +synonym: "cytosolic type I FAS complex" EXACT [] +is_a: GO:0031373 ! cytosolic fatty acid synthase complex + +[Term] +id: GO:0031375 +name: type II fatty acid synthase complex +namespace: cellular_component +def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] +synonym: "type II FAS" EXACT [] +synonym: "type II FAS complex" EXACT [] +synonym: "type II fatty acid synthase" EXACT [] +is_a: GO:0005835 ! fatty acid synthase complex + +[Term] +id: GO:0031376 +name: cytosolic type II fatty acid synthase complex +namespace: cellular_component +def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] +synonym: "cytosolic type II FAS complex" EXACT [] +is_a: GO:0031373 ! cytosolic fatty acid synthase complex +is_a: GO:0031375 ! type II fatty acid synthase complex + +[Term] +id: GO:0031377 +name: mitochondrial type II fatty acid synthase complex +namespace: cellular_component +def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] +synonym: "mitochondrial type II FAS complex" EXACT [] +is_a: GO:0031375 ! type II fatty acid synthase complex +is_a: GO:0044429 ! mitochondrial part + +[Term] +id: GO:0031378 +name: plastid type II fatty acid synthase complex +namespace: cellular_component +def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385] +synonym: "plastid type II FAS complex" EXACT [] +is_a: GO:0031375 ! type II fatty acid synthase complex +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0031379 +name: RNA-directed RNA polymerase complex +namespace: cellular_component +def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah] +is_a: GO:0030880 ! RNA polymerase complex + +[Term] +id: GO:0031380 +name: nuclear RNA-directed RNA polymerase complex +namespace: cellular_component +def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976] +synonym: "Rdr1 complex" NARROW [] +synonym: "RDRC" EXACT [] +is_a: GO:0031379 ! RNA-directed RNA polymerase complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0031381 +name: viral RNA-directed RNA polymerase complex +namespace: cellular_component +def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301] +is_a: GO:0031379 ! RNA-directed RNA polymerase complex + +[Term] +id: GO:0031382 +name: mating projection biogenesis +namespace: biological_process +def: "Formation of a projection by unicellular fungi in response to mating pheromone." [PMID:14734532] +is_a: GO:0030031 ! cell projection biogenesis +relationship: part_of GO:0000753 ! cellular morphogenesis during conjugation with cellular fusion + +[Term] +id: GO:0031383 +name: regulation of mating projection biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532] +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0031382 ! mating projection biogenesis + +[Term] +id: GO:0031384 +name: regulation of initiation of mating projection growth +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532] +is_a: GO:0031383 ! regulation of mating projection biogenesis + +[Term] +id: GO:0031385 +name: regulation of termination of mating projection growth +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532] +is_a: GO:0031383 ! regulation of mating projection biogenesis + +[Term] +id: GO:0031386 +name: protein tag +namespace: molecular_function +def: "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators] +subset: goslim_generic +subset: goslim_pir +synonym: "protein tagging activity" RELATED [] +synonym: "ubiquitin" RELATED [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0031387 +name: MPF complex +namespace: cellular_component +def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0031388 +name: organic acid phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0031389 +name: Rad17 RFC-like complex +namespace: cellular_component +def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] +synonym: "Rad17-RFC" EXACT [] +synonym: "Rad17-RLC" EXACT [] +synonym: "Rad24p RFC-like complex" EXACT [] +synonym: "RFC (Rad17)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0031390 +name: Ctf18 RFC-like complex +namespace: cellular_component +def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842] +synonym: "Ctf18-RFC" EXACT [] +synonym: "Ctf18-RLC" EXACT [] +synonym: "RFC (Ctf18)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0031391 +name: Elg1 RFC-like complex +namespace: cellular_component +def: "A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] +synonym: "Elg1-RFC" EXACT [] +synonym: "Elg1-RLC" EXACT [] +synonym: "RFC (Elg1)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0031392 +name: regulation of prostaglandin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] +synonym: "regulation of prostaglandin anabolism" EXACT [] +synonym: "regulation of prostaglandin biosynthesis" EXACT [] +synonym: "regulation of prostaglandin formation" EXACT [] +synonym: "regulation of prostaglandin synthesis" EXACT [] +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +relationship: regulates GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0031393 +name: negative regulation of prostaglandin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] +synonym: "down regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "down-regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "downregulation of prostaglandin biosynthetic process" EXACT [] +synonym: "inhibition of prostaglandin biosynthetic process" NARROW [] +synonym: "negative regulation of prostaglandin anabolism" EXACT [] +synonym: "negative regulation of prostaglandin biosynthesis" EXACT [] +synonym: "negative regulation of prostaglandin formation" EXACT [] +synonym: "negative regulation of prostaglandin synthesis" EXACT [] +is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process +is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process +relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0031394 +name: positive regulation of prostaglandin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] +synonym: "activation of prostaglandin biosynthetic process" NARROW [] +synonym: "positive regulation of prostaglandin anabolism" EXACT [] +synonym: "positive regulation of prostaglandin biosynthesis" EXACT [] +synonym: "positive regulation of prostaglandin formation" EXACT [] +synonym: "positive regulation of prostaglandin synthesis" EXACT [] +synonym: "stimulation of prostaglandin biosynthetic process" NARROW [] +synonym: "up regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "up-regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "upregulation of prostaglandin biosynthetic process" EXACT [] +is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process +is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process +relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0031395 +name: bursicon neuropeptide hormone complex +namespace: cellular_component +def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0031396 +name: regulation of protein ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin moieties to a protein." [GOC:mah] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0031397 +name: negative regulation of protein ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein." [GOC:mah] +synonym: "down regulation of protein ubiquitination" EXACT [] +synonym: "down-regulation of protein ubiquitination" EXACT [] +synonym: "downregulation of protein ubiquitination" EXACT [] +synonym: "inhibition of protein ubiquitination" NARROW [] +is_a: GO:0031396 ! regulation of protein ubiquitination +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0031398 +name: positive regulation of protein ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin moieties to a protein." [GOC:mah] +synonym: "activation of protein ubiquitination" NARROW [] +synonym: "stimulation of protein ubiquitination" NARROW [] +synonym: "up regulation of protein ubiquitination" EXACT [] +synonym: "up-regulation of protein ubiquitination" EXACT [] +synonym: "upregulation of protein ubiquitination" EXACT [] +is_a: GO:0031396 ! regulation of protein ubiquitination +is_a: GO:0031401 ! positive regulation of protein modification process +relationship: positively_regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0031399 +name: regulation of protein modification process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] +subset: gosubset_prok +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0006464 ! protein modification process + +[Term] +id: GO:0031400 +name: negative regulation of protein modification process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] +synonym: "down regulation of protein modification" EXACT [] +synonym: "down-regulation of protein modification" EXACT [] +synonym: "downregulation of protein modification" EXACT [] +synonym: "inhibition of protein modification" NARROW [] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +relationship: negatively_regulates GO:0006464 ! protein modification process + +[Term] +id: GO:0031401 +name: positive regulation of protein modification process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] +synonym: "activation of protein modification" NARROW [] +synonym: "stimulation of protein modification" NARROW [] +synonym: "up regulation of protein modification" EXACT [] +synonym: "up-regulation of protein modification" EXACT [] +synonym: "upregulation of protein modification" EXACT [] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +relationship: positively_regulates GO:0006464 ! protein modification process + +[Term] +id: GO:0031402 +name: sodium ion binding +namespace: molecular_function +def: "Interacting selectively with sodium ions (Na+)." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031420 ! alkali metal ion binding + +[Term] +id: GO:0031403 +name: lithium ion binding +namespace: molecular_function +def: "Interacting selectively with lithium ions (Li+)." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031420 ! alkali metal ion binding + +[Term] +id: GO:0031404 +name: chloride ion binding +namespace: molecular_function +def: "Interacting selectively with chloride ions (Cl-)." [GOC:mah] +subset: gosubset_prok +synonym: "chloride binding" EXACT [] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0031405 +name: lipoic acid binding +namespace: molecular_function +def: "Interacting selectively with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0031406 +name: carboxylic acid binding +namespace: molecular_function +def: "Interacting selectively with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0031407 +name: oxylipin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] +subset: gosubset_prok +synonym: "oxylipin metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0031408 +name: oxylipin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] +synonym: "oxylipin anabolism" EXACT [] +synonym: "oxylipin biosynthesis" EXACT [] +synonym: "oxylipin formation" EXACT [] +synonym: "oxylipin synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0031407 ! oxylipin metabolic process + +[Term] +id: GO:0031409 +name: pigment binding +namespace: molecular_function +def: "Interacting selectively with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0031410 +name: cytoplasmic vesicle +namespace: cellular_component +def: "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031982 ! vesicle +is_a: GO:0043229 ! intracellular organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0031411 +name: gas vesicle +namespace: cellular_component +def: "A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations." [PMID:8177173] +subset: gosubset_prok +is_a: GO:0031410 ! cytoplasmic vesicle +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0031412 +name: gas vesicle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah] +synonym: "gas vesicle biosynthesis" EXACT [] +synonym: "gas vesicle formation" EXACT [] +synonym: "gas vesicle organisation and biogenesis" EXACT [] +synonym: "gas vesicle organization and biogenesis" EXACT [] +is_a: GO:0016050 ! vesicle organization + +[Term] +id: GO:0031413 +name: regulation of buoyancy +namespace: biological_process +def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420] +synonym: "buoyancy regulation" EXACT [] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0031414 +name: N-terminal protein acetyltransferase complex +namespace: cellular_component +def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah] +synonym: "NAT complex" EXACT [] +is_a: GO:0031248 ! protein acetyltransferase complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0031415 +name: NatA complex +namespace: cellular_component +def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471] +synonym: "N-terminal acetyltransferase A complex" EXACT [] +is_a: GO:0031414 ! N-terminal protein acetyltransferase complex + +[Term] +id: GO:0031416 +name: NatB complex +namespace: cellular_component +def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] +synonym: "N-terminal acetyltransferase B complex" EXACT [] +is_a: GO:0031414 ! N-terminal protein acetyltransferase complex + +[Term] +id: GO:0031417 +name: NatC complex +namespace: cellular_component +def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471] +synonym: "N-terminal acetyltransferase C complex" EXACT [] +is_a: GO:0031414 ! N-terminal protein acetyltransferase complex + +[Term] +id: GO:0031418 +name: L-ascorbic acid binding +namespace: molecular_function +def: "Interacting selectively with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:mah] +synonym: "L-ascorbate binding" EXACT [] +synonym: "vitamin C binding" EXACT [] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0031419 +name: cobalamin binding +namespace: molecular_function +def: "Interacting selectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] +synonym: "vitamin B12 binding" EXACT [] +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0031420 +name: alkali metal ion binding +namespace: molecular_function +def: "Interacting selectively with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] +subset: gosubset_prok +is_a: GO:0043169 ! cation binding +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0031421 +name: invertasome +namespace: cellular_component +def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031422 +name: RecQ helicase-Topo III complex +namespace: cellular_component +def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139] +synonym: "Sgs1-Top3 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0031423 +name: hexon binding +namespace: molecular_function +def: "Interacting selectively with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031424 +name: keratinization +namespace: biological_process +def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:ebc] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0031425 +name: chloroplast RNA processing +namespace: biological_process +def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0031426 +name: polycistronic mRNA processing +namespace: biological_process +def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah] +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0031427 +name: response to methotrexate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0031428 +name: box C/D snoRNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type." [ISBN:0879695897] +is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0031429 +name: box H/ACA snoRNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type." [ISBN:0879695897] +is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex +is_a: GO:0044452 ! nucleolar part + +[Term] +id: GO:0031430 +name: M band +namespace: cellular_component +def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] +synonym: "M disc" EXACT [] +synonym: "M line" NARROW [] +synonym: "mesophragma" EXACT [] +synonym: "midline" BROAD [] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0031672 ! A band + +[Term] +id: GO:0031431 +name: Dbf4-dependent protein kinase complex +namespace: cellular_component +def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100] +synonym: "Cdc7-Dbf4 complex" NARROW [] +synonym: "DDK" EXACT [] +synonym: "Hsk1-Dfp1 kinase complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031432 +name: titin binding +namespace: molecular_function +def: "Interacting selectively with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031433 +name: telethonin binding +namespace: molecular_function +def: "Interacting selectively with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031434 +name: mitogen-activated protein kinase kinase binding +namespace: molecular_function +def: "Interacting selectively with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah] +synonym: "MAPKK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0031435 +name: mitogen-activated protein kinase kinase kinase binding +namespace: molecular_function +def: "Interacting selectively with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf] +synonym: "MAPKKK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0031436 +name: BRCA1-BARD1 complex +namespace: cellular_component +def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex + +[Term] +id: GO:0031437 +name: regulation of mRNA cleavage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] +is_a: GO:0050684 ! regulation of mRNA processing +relationship: regulates GO:0006379 ! mRNA cleavage + +[Term] +id: GO:0031438 +name: negative regulation of mRNA cleavage +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah] +synonym: "down regulation of mRNA cleavage" EXACT [] +synonym: "down-regulation of mRNA cleavage" EXACT [] +synonym: "downregulation of mRNA cleavage" EXACT [] +synonym: "inhibition of mRNA cleavage" NARROW [] +is_a: GO:0031437 ! regulation of mRNA cleavage +is_a: GO:0050686 ! negative regulation of mRNA processing +relationship: negatively_regulates GO:0006379 ! mRNA cleavage + +[Term] +id: GO:0031439 +name: positive regulation of mRNA cleavage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah] +synonym: "activation of mRNA cleavage" NARROW [] +synonym: "stimulation of mRNA cleavage" NARROW [] +synonym: "up regulation of mRNA cleavage" EXACT [] +synonym: "up-regulation of mRNA cleavage" EXACT [] +synonym: "upregulation of mRNA cleavage" EXACT [] +is_a: GO:0031437 ! regulation of mRNA cleavage +is_a: GO:0050685 ! positive regulation of mRNA processing +relationship: positively_regulates GO:0006379 ! mRNA cleavage + +[Term] +id: GO:0031440 +name: regulation of mRNA 3'-end processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] +is_a: GO:0050684 ! regulation of mRNA processing +relationship: regulates GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0031441 +name: negative regulation of mRNA 3'-end processing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] +synonym: "down regulation of mRNA 3'-end processing" EXACT [] +synonym: "down-regulation of mRNA 3'-end processing" EXACT [] +synonym: "downregulation of mRNA 3'-end processing" EXACT [] +synonym: "inhibition of mRNA 3'-end processing" NARROW [] +is_a: GO:0031440 ! regulation of mRNA 3'-end processing +is_a: GO:0050686 ! negative regulation of mRNA processing +relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0031442 +name: positive regulation of mRNA 3'-end processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] +synonym: "activation of mRNA 3'-end processing" NARROW [] +synonym: "stimulation of mRNA 3'-end processing" NARROW [] +synonym: "up regulation of mRNA 3'-end processing" EXACT [] +synonym: "up-regulation of mRNA 3'-end processing" EXACT [] +synonym: "upregulation of mRNA 3'-end processing" EXACT [] +is_a: GO:0031440 ! regulation of mRNA 3'-end processing +is_a: GO:0050685 ! positive regulation of mRNA processing +relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0031443 +name: fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "A process whereby force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle] +synonym: "fast-twitch skeletal fiber contraction" EXACT [] +synonym: "fast-twitch skeletal fibre contraction" EXACT [] +synonym: "fast-twitch skeletal muscle fibre contraction" EXACT [] +synonym: "fast-twitch skeletal myofiber contraction" EXACT [] +synonym: "fast-twitch skeletal myofibre contraction" EXACT [] +is_a: GO:0014721 ! twitch skeletal muscle contraction + +[Term] +id: GO:0031444 +name: slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "A process whereby force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle] +synonym: "slow-twitch skeletal muscle fibre contraction" EXACT [] +is_a: GO:0014721 ! twitch skeletal muscle contraction + +[Term] +id: GO:0031445 +name: regulation of heterochromatin formation +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +relationship: regulates GO:0031507 ! heterochromatin formation + +[Term] +id: GO:0031446 +name: regulation of fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction +relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031447 +name: negative regulation of fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW [] +synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031448 +name: positive regulation of fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "activation of fast-twitch skeletal muscle contraction" NARROW [] +synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW [] +synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT [] +is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031449 +name: regulation of slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction +relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031450 +name: negative regulation of slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW [] +synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031451 +name: positive regulation of slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "activation of slow-twitch skeletal muscle contraction" NARROW [] +synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW [] +synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT [] +is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031452 +name: negative regulation of heterochromatin formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah] +synonym: "down regulation of heterochromatin formation" EXACT [] +synonym: "down-regulation of heterochromatin formation" EXACT [] +synonym: "downregulation of heterochromatin formation" EXACT [] +synonym: "inhibition of heterochromatin formation" NARROW [] +is_a: GO:0031445 ! regulation of heterochromatin formation +is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly +relationship: negatively_regulates GO:0031507 ! heterochromatin formation + +[Term] +id: GO:0031453 +name: positive regulation of heterochromatin formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] +synonym: "activation of heterochromatin formation" NARROW [] +synonym: "stimulation of heterochromatin formation" NARROW [] +synonym: "up regulation of heterochromatin formation" EXACT [] +synonym: "up-regulation of heterochromatin formation" EXACT [] +synonym: "upregulation of heterochromatin formation" EXACT [] +is_a: GO:0031445 ! regulation of heterochromatin formation +is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly +relationship: positively_regulates GO:0031507 ! heterochromatin formation + +[Term] +id: GO:0031454 +name: regulation of extent of heterochromatin formation +namespace: biological_process +def: "Any process that modulates the extent or location of heterochromatin formation." [GOC:mah] +synonym: "regulation of heterochromatin spreading" RELATED [] +is_a: GO:0031445 ! regulation of heterochromatin formation + +[Term] +id: GO:0031455 +name: glycine betaine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah] +subset: gosubset_prok +synonym: "glycine betaine metabolism" EXACT [] +synonym: "N-trimethylglycine metabolic process" EXACT [] +synonym: "N-trimethylglycine metabolism" EXACT [] +is_a: GO:0006577 ! betaine metabolic process + +[Term] +id: GO:0031456 +name: glycine betaine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah] +subset: gosubset_prok +synonym: "glycine betaine anabolism" EXACT [] +synonym: "glycine betaine biosynthesis" EXACT [] +synonym: "glycine betaine formation" EXACT [] +synonym: "glycine betaine synthesis" EXACT [] +synonym: "N-trimethylglycine biosynthesis" EXACT [] +synonym: "N-trimethylglycine biosynthetic process" EXACT [] +is_a: GO:0006578 ! betaine biosynthetic process +is_a: GO:0031455 ! glycine betaine metabolic process + +[Term] +id: GO:0031457 +name: glycine betaine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah] +synonym: "glycine betaine breakdown" EXACT [] +synonym: "glycine betaine catabolism" EXACT [] +synonym: "glycine betaine degradation" EXACT [] +synonym: "N-trimethylglycine catabolic process" EXACT [] +synonym: "N-trimethylglycine catabolism" EXACT [] +is_a: GO:0006579 ! betaine catabolic process +is_a: GO:0031455 ! glycine betaine metabolic process + +[Term] +id: GO:0031458 +name: betaine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg] +synonym: "betaine ABC transporter" NARROW [] +is_a: GO:0031263 ! amine-transporting ATPase activity + +[Term] +id: GO:0031459 +name: glycine betaine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg] +synonym: "glycine betaine ABC transporter" NARROW [] +synonym: "N-trimethylglycine-transporting ATPase activity" EXACT [] +is_a: GO:0031458 ! betaine-transporting ATPase activity + +[Term] +id: GO:0031460 +name: glycine betaine transport +namespace: biological_process +def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of, within or between cells." [GOC:mah] +synonym: "N-trimethylglycine transport" EXACT [] +is_a: GO:0015838 ! betaine transport + +[Term] +id: GO:0031461 +name: cullin-RING ubiquitin ligase complex +namespace: cellular_component +def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] +synonym: "CRL complex" EXACT [] +synonym: "cullin complex" EXACT [] +synonym: "cullin-RING ligase" RELATED [] +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:0031462 +name: Cul2-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] +synonym: "CBC complex" BROAD [] +synonym: "CDL2 complex" EXACT [] +synonym: "CRL2 complex" EXACT [] +synonym: "cullin-RING ligase 2" EXACT [] +synonym: "EC2S complex" BROAD [] +synonym: "ECS complex" BROAD [] +synonym: "SCF2 complex" RELATED [] +synonym: "VBC complex" NARROW [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031463 +name: Cul3-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] +synonym: "BC3B complex" EXACT [] +synonym: "BCR3 complex" EXACT [] +synonym: "CDL3 complex" EXACT [] +synonym: "CRL3 complex" EXACT [] +synonym: "cullin-RING ligase 3" EXACT [] +synonym: "SCF3 complex" RELATED [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031464 +name: Cul4A-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063] +synonym: "CDL4 complex" EXACT [] +synonym: "CRL4 complex" EXACT [] +synonym: "cullin-RING ligase 4A" EXACT [] +synonym: "DCX complex" EXACT [] +synonym: "SCF4 complex" RELATED [] +synonym: "VDC complex" NARROW [] +is_a: GO:0080008 ! CUL4 RING ubiquitin ligase complex + +[Term] +id: GO:0031465 +name: Cul4B-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] +synonym: "cullin-RING ligase 4B" EXACT [] +is_a: GO:0080008 ! CUL4 RING ubiquitin ligase complex + +[Term] +id: GO:0031466 +name: Cul5-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] +synonym: "CDL5 complex" EXACT [] +synonym: "CRL5 complex" EXACT [] +synonym: "cullin-RING ligase 5" EXACT [] +synonym: "EC2S complex" BROAD [] +synonym: "SCF5 complex" RELATED [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031467 +name: Cul7-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] +synonym: "CDL7 complex" EXACT [] +synonym: "CRL7 complex" EXACT [] +synonym: "cullin-RING ligase 7" EXACT [] +synonym: "SCF7 complex" EXACT [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031468 +name: nuclear envelope reassembly +namespace: biological_process +def: "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah] +is_a: GO:0006998 ! nuclear envelope organization + +[Term] +id: GO:0031469 +name: polyhedral organelle +namespace: cellular_component +def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0031470 +name: carboxysome +namespace: cellular_component +def: "An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708] +subset: gosubset_prok +is_a: GO:0031469 ! polyhedral organelle + +[Term] +id: GO:0031471 +name: ethanolamine degradation polyhedral organelle +namespace: cellular_component +def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753] +subset: gosubset_prok +synonym: "ethanolamine metabolosome" RELATED [] +is_a: GO:0031469 ! polyhedral organelle + +[Term] +id: GO:0031472 +name: propanediol degradation polyhedral organelle +namespace: cellular_component +def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] +subset: gosubset_prok +is_a: GO:0031469 ! polyhedral organelle + +[Term] +id: GO:0031473 +name: myosin III binding +namespace: molecular_function +def: "Interacting selectively with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0031474 +name: myosin IV complex +namespace: cellular_component +def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031475 +name: myosin V complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031476 +name: myosin VI complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031477 +name: myosin VII complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031478 +name: myosin VIII complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031479 +name: myosin IX complex +namespace: cellular_component +def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031480 +name: myosin X complex +namespace: cellular_component +def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031481 +name: myosin XI complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031482 +name: myosin XII complex +namespace: cellular_component +def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031483 +name: myosin XIII complex +namespace: cellular_component +def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031484 +name: myosin XIV complex +namespace: cellular_component +def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031485 +name: myosin XV complex +namespace: cellular_component +def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031486 +name: myosin XVI complex +namespace: cellular_component +def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031487 +name: myosin XVII complex +namespace: cellular_component +def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031488 +name: myosin XVIII complex +namespace: cellular_component +def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031489 +name: myosin V binding +namespace: molecular_function +def: "Interacting selectively with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0031490 +name: chromatin DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA that is assembled into chromatin." [GOC:mah] +is_a: GO:0003682 ! chromatin binding +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0031491 +name: nucleosome binding +namespace: molecular_function +def: "Interacting selectively with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] +is_a: GO:0003682 ! chromatin binding + +[Term] +id: GO:0031492 +name: nucleosomal DNA binding +namespace: molecular_function +def: "Interacting selectively with the DNA portion of a nucleosome." [GOC:mah] +is_a: GO:0031490 ! chromatin DNA binding +is_a: GO:0031491 ! nucleosome binding + +[Term] +id: GO:0031493 +name: nucleosomal histone binding +namespace: molecular_function +def: "Interacting selectively with a histone that is assembled into a nucleosome." [GOC:mah] +is_a: GO:0031491 ! nucleosome binding +is_a: GO:0042393 ! histone binding + +[Term] +id: GO:0031494 +name: regulation of mating type switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah] +is_a: GO:0051052 ! regulation of DNA metabolic process +is_a: GO:0051302 ! regulation of cell division +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0007533 ! mating type switching + +[Term] +id: GO:0031495 +name: negative regulation of mating type switching +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mating type switching." [GOC:mah] +synonym: "down regulation of mating type switching" EXACT [] +synonym: "down-regulation of mating type switching" EXACT [] +synonym: "downregulation of mating type switching" EXACT [] +synonym: "inhibition of mating type switching" NARROW [] +is_a: GO:0031494 ! regulation of mating type switching +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0007533 ! mating type switching + +[Term] +id: GO:0031496 +name: positive regulation of mating type switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah] +synonym: "activation of mating type switching" NARROW [] +synonym: "stimulation of mating type switching" NARROW [] +synonym: "up regulation of mating type switching" EXACT [] +synonym: "up-regulation of mating type switching" EXACT [] +synonym: "upregulation of mating type switching" EXACT [] +is_a: GO:0031494 ! regulation of mating type switching +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0007533 ! mating type switching + +[Term] +id: GO:0031497 +name: chromatin assembly +namespace: biological_process +def: "The assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html] +is_a: GO:0006333 ! chromatin assembly or disassembly +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0006323 ! DNA packaging + +[Term] +id: GO:0031498 +name: chromatin disassembly +namespace: biological_process +def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html] +is_a: GO:0006333 ! chromatin assembly or disassembly +is_a: GO:0043624 ! cellular protein complex disassembly + +[Term] +id: GO:0031499 +name: TRAMP complex +namespace: cellular_component +def: "A multiprotein complex, which in yeast consists of Trf4p, Air1p or Air2p and Mtr4p. This nuclear RNA surveillance and quality control complex is involved in the distributive polyadenylation of substrates that include: hypomodified and incorrectly folded tRNAs, snoRNA precursors and rRNA precursors. It is also required for the degradative activity of the nuclear exosome in vivo." [PMID:15828860, PMID:15935758] +synonym: "Trf4 complex" EXACT [] +synonym: "Trf4 poly(A) polymerase complex" EXACT [] +synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0031500 +name: Tea1 cell-end complex +namespace: cellular_component +def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270] +is_a: GO:0005875 ! microtubule associated complex +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0000133 ! polarisome + +[Term] +id: GO:0031501 +name: mannosyltransferase complex +namespace: cellular_component +def: "A complex that posseses mannosyltransferase activity." [GOC:mah] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031502 +name: dolichyl-phosphate-mannose-protein mannosyltransferase complex +namespace: cellular_component +def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, PMID:15948957] +synonym: "PMT family mannosyltransferase complex" RELATED [] +synonym: "protein O-mannosyltransferase complex" EXACT [] +is_a: GO:0031501 ! mannosyltransferase complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0031503 +name: protein complex localization +namespace: biological_process +def: "Any process by which a protein complex is transported to, or maintained in, a specific location." [GOC:mah] +subset: gosubset_prok +synonym: "establishment and maintenance of protein complex localization" EXACT [] +is_a: GO:0051179 ! localization + +[Term] +id: GO:0031504 +name: peptidoglycan-based cell wall organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall; as in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "cell wall organisation and biogenesis (sensu Bacteria)" EXACT [] +synonym: "cell wall organization and biogenesis (sensu Bacteria)" EXACT [] +synonym: "peptidoglycan-based cell wall organization and biogenesis" EXACT [] +is_a: GO:0007047 ! cell wall organization + +[Term] +id: GO:0031505 +name: fungal-type cell wall organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] +synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED [] +synonym: "cell wall organisation and biogenesis (sensu Fungi)" EXACT [] +synonym: "cell wall organization and biogenesis (sensu Fungi)" EXACT [] +synonym: "chitin- and beta-glucan-containing cell wall organisation and biogenesis" NARROW [] +synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW [] +synonym: "chitin-containing cell wall organization and biogenesis" RELATED [] +synonym: "fungal-type cell wall organization and biogenesis" RELATED [] +is_a: GO:0007047 ! cell wall organization + +[Term] +id: GO:0031506 +name: cell wall glycoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues other than as a moiety of nucleic acid." [GOC:mah] +subset: gosubset_prok +synonym: "cell wall glycoprotein anabolism" EXACT [] +synonym: "cell wall glycoprotein biosynthesis" EXACT [] +synonym: "cell wall glycoprotein formation" EXACT [] +synonym: "cell wall glycoprotein synthesis" EXACT [] +is_a: GO:0009101 ! glycoprotein biosynthetic process +is_a: GO:0010382 ! cell wall metabolic process + +[Term] +id: GO:0031507 +name: heterochromatin formation +namespace: biological_process +def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] +synonym: "heterochromatin assembly" EXACT [] +is_a: GO:0006338 ! chromatin remodeling +is_a: GO:0031497 ! chromatin assembly + +[Term] +id: GO:0031508 +name: centromeric heterochromatin formation +namespace: biological_process +def: "The assembly of chromatin into heterochromatin near the centromere." [GOC:mah] +synonym: "centric heterochromatin formation" EXACT [] +synonym: "centromeric heterochromatin assembly" EXACT [] +synonym: "centromeric heterochromatin biosynthesis" EXACT [] +is_a: GO:0031055 ! chromatin remodeling at centromere +is_a: GO:0031507 ! heterochromatin formation +relationship: part_of GO:0034508 ! centromere complex assembly + +[Term] +id: GO:0031509 +name: telomeric heterochromatin formation +namespace: biological_process +def: "The assembly of chromatin into heterochromatin at the telomere." [GOC:mah] +synonym: "telomeric heterochromatin assembly" EXACT [] +is_a: GO:0031507 ! heterochromatin formation + +[Term] +id: GO:0031510 +name: SUMO activating enzyme complex +namespace: cellular_component +def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841] +synonym: "SAE" EXACT [] +synonym: "SUMO E1 activator enzyme complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0031511 +name: Mis6-Sim4 complex +namespace: cellular_component +def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182] +synonym: "Mis6 centromere subcomplex" NARROW [] +synonym: "Sim4 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000939 ! inner kinetochore of condensed chromosome + +[Term] +id: GO:0031512 +name: motile primary cilium +namespace: cellular_component +def: "A specialized primary cilium that contains a 9 + 0 arrangement of microtubules, radial spokes, and a dynein apparatus, but no inner doublet microtubules. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface." [GOC:kmv] +is_a: GO:0005929 ! cilium + +[Term] +id: GO:0031513 +name: nonmotile primary cilium +namespace: cellular_component +def: "An immotile primary cilium that may be missing the central pair of microtubules, or the central pair of microtubules and outer dynein arms. Some primary cilia also have altered arrangements of outer microtubules (fewer than nine and/or not always present as doublets). Nonmotile primary cilia typically function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kna] +is_a: GO:0005929 ! cilium + +[Term] +id: GO:0031514 +name: motile secondary cilium +namespace: cellular_component +def: "A cilium that consists of a 9 + 2 arrangement of microtubules, radial spokes, and a dynein apparatus. Motile cilia, found on cells that line the lumenal ducts of various tissues, beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface." [GOC:kmv] +is_a: GO:0005929 ! cilium + +[Term] +id: GO:0031515 +name: tRNA (m1A) methyltransferase complex +namespace: cellular_component +def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239] +subset: gosubset_prok +is_a: GO:0043527 ! tRNA methyltransferase complex + +[Term] +id: GO:0031516 +name: far-red light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln] +is_a: GO:0009883 ! red or far-red light photoreceptor activity + +[Term] +id: GO:0031517 +name: red light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln] +is_a: GO:0009883 ! red or far-red light photoreceptor activity + +[Term] +id: GO:0031518 +name: CBF3 complex +namespace: cellular_component +def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0031519 +name: PcG protein complex +namespace: cellular_component +def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908] +subset: goslim_pir +synonym: "Polycomb Group protein complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0031520 +name: plasma membrane of cell tip +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0051286 ! cell tip + +[Term] +id: GO:0031521 +name: spitzenkorper +namespace: cellular_component +def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part +relationship: part_of GO:0001411 ! hyphal tip + +[Term] +id: GO:0031522 +name: cell envelope Sec protein transport complex +namespace: cellular_component +def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057] +comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'Sec-complex associated translocon complex ; GO:0031206'. +subset: gosubset_prok +synonym: "plasma membrane Sec complex" RELATED [] +synonym: "Sec complex (sensu Bacteria)" EXACT [] +synonym: "Sec secretion complex" NARROW [] +synonym: "Sec translocation complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0031523 +name: Myb complex +namespace: cellular_component +def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] +synonym: "Myeloblastosis proto-oncogene protein complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0031524 +name: menthol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] +subset: gosubset_prok +synonym: "menthol metabolism" EXACT [] +is_a: GO:0043692 ! monoterpene metabolic process + +[Term] +id: GO:0031525 +name: menthol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] +subset: gosubset_prok +synonym: "menthol anabolism" EXACT [] +synonym: "menthol biosynthesis" EXACT [] +synonym: "menthol formation" EXACT [] +synonym: "menthol synthesis" EXACT [] +is_a: GO:0031524 ! menthol metabolic process +is_a: GO:0043693 ! monoterpene biosynthetic process + +[Term] +id: GO:0031526 +name: brush border membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0005903 ! brush border + +[Term] +id: GO:0031527 +name: filopodium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0030175 ! filopodium + +[Term] +id: GO:0031528 +name: microvillus membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0005902 ! microvillus + +[Term] +id: GO:0031529 +name: ruffle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235] +synonym: "ruffle organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0031530 +name: gonadotropin-releasing hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [PMID:15196882] +is_a: GO:0051428 ! peptide hormone receptor binding + +[Term] +id: GO:0031531 +name: thyrotropin-releasing hormone receptor binding +namespace: molecular_function +alt_id: GO:0031888 +def: "Interacting selectively with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728] +synonym: "thyrotropin-releasing hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding +is_a: GO:0051428 ! peptide hormone receptor binding + +[Term] +id: GO:0031532 +name: actin cytoskeleton reorganization +namespace: biological_process +alt_id: GO:0007012 +def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] +synonym: "actin cytoskeleton remodeling" EXACT [] +synonym: "actin cytoskeleton reorganisation" EXACT [] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0031533 +name: mRNA capping enzyme complex +namespace: cellular_component +def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] +synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT [] +synonym: "mRNA cap methyltransferase complex" EXACT [] +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0031534 +name: minus-end directed microtubule sliding +namespace: biological_process +def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw] +is_a: GO:0051012 ! microtubule sliding + +[Term] +id: GO:0031535 +name: plus-end directed microtubule sliding +namespace: biological_process +def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw] +is_a: GO:0051012 ! microtubule sliding + +[Term] +id: GO:0031536 +name: positive regulation of exit from mitosis +namespace: biological_process +def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] +synonym: "activation of exit from mitosis" NARROW [] +synonym: "stimulation of exit from mitosis" NARROW [] +synonym: "up regulation of exit from mitosis" EXACT [] +synonym: "up-regulation of exit from mitosis" EXACT [] +synonym: "upregulation of exit from mitosis" EXACT [] +is_a: GO:0007096 ! regulation of exit from mitosis +is_a: GO:0045840 ! positive regulation of mitosis +relationship: positively_regulates GO:0010458 ! exit from mitosis + +[Term] +id: GO:0031537 +name: regulation of anthocyanin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] +synonym: "regulation of anthocyanin metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0046283 ! anthocyanin metabolic process + +[Term] +id: GO:0031538 +name: negative regulation of anthocyanin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] +synonym: "down regulation of anthocyanin metabolic process" EXACT [] +synonym: "down-regulation of anthocyanin metabolic process" EXACT [] +synonym: "downregulation of anthocyanin metabolic process" EXACT [] +synonym: "inhibition of anthocyanin metabolic process" NARROW [] +synonym: "negative regulation of anthocyanin metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: negatively_regulates GO:0046283 ! anthocyanin metabolic process + +[Term] +id: GO:0031539 +name: positive regulation of anthocyanin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] +synonym: "activation of anthocyanin metabolic process" NARROW [] +synonym: "positive regulation of anthocyanin metabolism" EXACT [] +synonym: "stimulation of anthocyanin metabolic process" NARROW [] +synonym: "up regulation of anthocyanin metabolic process" EXACT [] +synonym: "up-regulation of anthocyanin metabolic process" EXACT [] +synonym: "upregulation of anthocyanin metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: positively_regulates GO:0046283 ! anthocyanin metabolic process + +[Term] +id: GO:0031540 +name: regulation of anthocyanin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] +synonym: "regulation of anthocyanin anabolism" EXACT [] +synonym: "regulation of anthocyanin biosynthesis" EXACT [] +synonym: "regulation of anthocyanin formation" EXACT [] +synonym: "regulation of anthocyanin synthesis" EXACT [] +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: regulates GO:0009718 ! anthocyanin biosynthetic process + +[Term] +id: GO:0031541 +name: negative regulation of anthocyanin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] +synonym: "down regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "down-regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "downregulation of anthocyanin biosynthetic process" EXACT [] +synonym: "inhibition of anthocyanin biosynthetic process" NARROW [] +synonym: "negative regulation of anthocyanin anabolism" EXACT [] +synonym: "negative regulation of anthocyanin biosynthesis" EXACT [] +synonym: "negative regulation of anthocyanin formation" EXACT [] +synonym: "negative regulation of anthocyanin synthesis" EXACT [] +is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process +is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process +is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process +relationship: negatively_regulates GO:0009718 ! anthocyanin biosynthetic process + +[Term] +id: GO:0031542 +name: positive regulation of anthocyanin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] +synonym: "activation of anthocyanin biosynthetic process" NARROW [] +synonym: "positive regulation of anthocyanin anabolism" EXACT [] +synonym: "positive regulation of anthocyanin biosynthesis" EXACT [] +synonym: "positive regulation of anthocyanin formation" EXACT [] +synonym: "positive regulation of anthocyanin synthesis" EXACT [] +synonym: "stimulation of anthocyanin biosynthetic process" NARROW [] +synonym: "up regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "up-regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "upregulation of anthocyanin biosynthetic process" EXACT [] +is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process +is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process +is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process +relationship: positively_regulates GO:0009718 ! anthocyanin biosynthetic process + +[Term] +id: GO:0031543 +name: peptidyl-proline dioxygenase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein." [GOC:mah] +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0031544 +name: peptidyl-proline 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah] +is_a: GO:0031543 ! peptidyl-proline dioxygenase activity + +[Term] +id: GO:0031545 +name: peptidyl-proline 4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah] +synonym: "HIF-type prolyl 4-hydroxylase" NARROW [] +synonym: "prolyl 4-hydroxylase" BROAD [] +is_a: GO:0031543 ! peptidyl-proline dioxygenase activity + +[Term] +id: GO:0031546 +name: brain-derived neurotrophic factor receptor binding +namespace: molecular_function +def: "Interacting selectively with the brain-derived neurotrophic factor receptor." [GOC:mah] +synonym: "BDNF receptor binding" EXACT [] +synonym: "brain-derived neurotrophic factor ligand" NARROW [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0031547 +name: brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "BDNF receptor signaling pathway" EXACT [] +synonym: "BDNF signalling pathway" EXACT [] +synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0031548 +name: regulation of brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] +synonym: "regulation of BDNF receptor signaling pathway" EXACT [] +synonym: "regulation of BDNF receptor signalling pathway" EXACT [] +synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway + +[Term] +id: GO:0031549 +name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] +synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of BDNF receptor signaling pathway" EXACT [] +synonym: "negative regulation of BDNF receptor signalling pathway" EXACT [] +synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway +relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway + +[Term] +id: GO:0031550 +name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] +synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of BDNF receptor signaling pathway" EXACT [] +synonym: "positive regulation of BDNF receptor signalling pathway" EXACT [] +synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] +synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway +relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway + +[Term] +id: GO:0031551 +name: regulation of brain-derived neurotrophic factor receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah] +synonym: "regulation of BDNF receptor activity" EXACT [] +is_a: GO:0010469 ! regulation of receptor activity +is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway +is_a: GO:0043393 ! regulation of protein binding +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0031552 +name: negative regulation of brain-derived neurotrophic factor receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah] +synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW [] +synonym: "negative regulation of BDNF receptor activity" EXACT [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway +is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor receptor activity +is_a: GO:0032091 ! negative regulation of protein binding + +[Term] +id: GO:0031553 +name: positive regulation of brain-derived neurotrophic factor receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah] +synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW [] +synonym: "positive regulation of BDNF receptor activity" EXACT [] +synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW [] +synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT [] +is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway +is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor receptor activity +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0031554 +name: regulation of transcription termination +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent, or location of transcription termination." [GOC:mlg] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0043244 ! regulation of protein complex disassembly +relationship: regulates GO:0006353 ! transcription termination + +[Term] +id: GO:0031555 +name: transcriptional attenuation +namespace: biological_process +def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682] +is_a: GO:0031554 ! regulation of transcription termination + +[Term] +id: GO:0031556 +name: transcriptional attenuation by ribosome +namespace: biological_process +def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682] +synonym: "ribosome-mediated transcriptional " EXACT [GOC:dph, GOC:tb] +is_a: GO:0031555 ! transcriptional attenuation + +[Term] +id: GO:0031557 +name: induction of programmed cell death in response to chemical stimulus +namespace: biological_process +def: "A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah] +synonym: "induction of programmed cell death in response to chemical substance" EXACT [] +is_a: GO:0012502 ! induction of programmed cell death +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0031558 +name: induction of apoptosis in response to chemical stimulus +namespace: biological_process +def: "Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah] +synonym: "induction of apoptosis in response to chemical substance" EXACT [] +is_a: GO:0008624 ! induction of apoptosis by extracellular signals +is_a: GO:0031557 ! induction of programmed cell death in response to chemical stimulus + +[Term] +id: GO:0031559 +name: oxidosqualene cyclase activity +namespace: molecular_function +def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to triterpene." [GOC:ct] +subset: gosubset_prok +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0031560 +name: cellular bud neck polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0005935 ! cellular bud neck + +[Term] +id: GO:0031561 +name: cellular bud tip polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0005934 ! cellular bud tip + +[Term] +id: GO:0031562 +name: hyphal tip polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0001411 ! hyphal tip + +[Term] +id: GO:0031563 +name: mating projection tip polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532] +is_a: GO:0000133 ! polarisome +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0043332 ! mating projection tip + +[Term] +id: GO:0031564 +name: transcription antitermination +namespace: biological_process +def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site." [ISBN:0198577788, PMID:12456320] +synonym: "transcriptional readthrough" EXACT [] +is_a: GO:0031555 ! transcriptional attenuation + +[Term] +id: GO:0031565 +name: cytokinesis checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum." [GOC:mah, PMID:15647375] +synonym: "contractile ring checkpoint" EXACT [] +is_a: GO:0000075 ! cell cycle checkpoint + +[Term] +id: GO:0031566 +name: contractile ring maintenance involved in cytokinesis +namespace: biological_process +def: "The cell cycle process whereby the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures." [GOC:dph, GOC:tb, GOC:vw] +synonym: "cytokinesis, contractile ring maintenance" EXACT [GOC:dph, GOC:tb] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0060249 ! anatomical structure homeostasis +relationship: part_of GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0031567 +name: cell size control checkpoint +namespace: biological_process +def: "Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mah] +is_a: GO:0007093 ! mitotic cell cycle checkpoint + +[Term] +id: GO:0031568 +name: G1/S transition size control checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size." [GOC:mah] +is_a: GO:0031567 ! cell size control checkpoint +is_a: GO:0031575 ! G1/S transition checkpoint + +[Term] +id: GO:0031569 +name: G2/M transition size control checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size." [GOC:mah] +is_a: GO:0031567 ! cell size control checkpoint +is_a: GO:0031576 ! G2/M transition checkpoint + +[Term] +id: GO:0031570 +name: DNA integrity checkpoint +namespace: biological_process +def: "Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure." [GOC:mah, GOC:vw] +is_a: GO:0000075 ! cell cycle checkpoint + +[Term] +id: GO:0031571 +name: G1 DNA damage checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that arrests cell cycle progression G1 phase in response to DNA damage." [GOC:mah] +is_a: GO:0000077 ! DNA damage checkpoint +is_a: GO:0031575 ! G1/S transition checkpoint + +[Term] +id: GO:0031572 +name: G2/M transition DNA damage checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah] +is_a: GO:0000077 ! DNA damage checkpoint +is_a: GO:0031576 ! G2/M transition checkpoint + +[Term] +id: GO:0031573 +name: intra-S DNA damage checkpoint +namespace: biological_process +def: "The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession." [GOC:vw] +is_a: GO:0000077 ! DNA damage checkpoint + +[Term] +id: GO:0031574 +name: S-M checkpoint +namespace: biological_process +def: "A cell cycle checkpoint which halts replication in response to nucleotide depletion." [GOC:vw] +is_a: GO:0000077 ! DNA damage checkpoint +is_a: GO:0007093 ! mitotic cell cycle checkpoint + +[Term] +id: GO:0031575 +name: G1/S transition checkpoint +namespace: biological_process +def: "Any cell cycle checkpoint that blocks entry into S phase." [GOC:mah] +is_a: GO:0007093 ! mitotic cell cycle checkpoint + +[Term] +id: GO:0031576 +name: G2/M transition checkpoint +namespace: biological_process +def: "Any cell cycle checkpoint that blocks entry into M phase." [GOC:mah] +synonym: "G2/M checkpoint" EXACT [] +is_a: GO:0007093 ! mitotic cell cycle checkpoint + +[Term] +id: GO:0031577 +name: spindle checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, PMID:15897186] +synonym: "SAC" BROAD [] +synonym: "spindle assembly checkpoint" EXACT [] +is_a: GO:0000075 ! cell cycle checkpoint + +[Term] +id: GO:0031578 +name: mitotic cell cycle spindle orientation checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected." [GOC:clt, PMID:14616062] +synonym: "SOC" EXACT [] +synonym: "spindle position checkpoint" EXACT [] +synonym: "SPOC" EXACT [] +is_a: GO:0007093 ! mitotic cell cycle checkpoint +is_a: GO:0031577 ! spindle checkpoint + +[Term] +id: GO:0031579 +name: membrane raft organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah] +synonym: "lipid raft organization and biogenesis" EXACT [] +synonym: "membrane raft organization and biogenesis" EXACT [] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0031580 +name: membrane raft distribution +namespace: biological_process +def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah] +synonym: "lipid raft distribution" EXACT [] +is_a: GO:0031579 ! membrane raft organization +is_a: GO:0051665 ! membrane raft localization + +[Term] +id: GO:0031581 +name: hemidesmosome assembly +namespace: biological_process +def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403] +is_a: GO:0007044 ! cell-substrate junction assembly + +[Term] +id: GO:0031582 +name: replication fork arrest at rDNA repeats +namespace: biological_process +def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw] +synonym: "replication fork arrest at ribosomal DNA repeats" EXACT [] +synonym: "replication fork blocking at rDNA repeats" EXACT [] +is_a: GO:0043007 ! maintenance of rDNA +is_a: GO:0043111 ! replication fork arrest + +[Term] +id: GO:0031583 +name: G-protein signaling, phospholipase D activating pathway +namespace: biological_process +def: "A G-protein coupled signaling pathway that results in the activation of phospholipase D, causing an increase in cellular levels of phosphatidic acid." [GOC:mah, PMID:11812783, PMID:15924269] +synonym: "G-protein signalling, phospholipase D activating pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0031584 +name: phospholipase D activation +namespace: biological_process +def: "The series of molecular signals that results in the upregulation of phospholipase D activity in response to the initial signal." [GOC:mah] +is_a: GO:0031583 ! G-protein signaling, phospholipase D activating pathway + +[Term] +id: GO:0031585 +name: regulation of inositol-1,4,5-triphosphate receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah] +synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0010469 ! regulation of receptor activity + +[Term] +id: GO:0031586 +name: negative regulation of inositol-1,4,5-triphosphate receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah] +synonym: "down regulation of IP3 receptor activity" EXACT [] +synonym: "down-regulation of IP3 receptor activity" EXACT [] +synonym: "downregulation of IP3 receptor activity" EXACT [] +synonym: "inhibition of IP3 receptor activity" NARROW [] +synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0031585 ! regulation of inositol-1,4,5-triphosphate receptor activity + +[Term] +id: GO:0031587 +name: positive regulation of inositol-1,4,5-triphosphate receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah] +synonym: "activation of IP3 receptor activity" NARROW [] +synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph] +synonym: "stimulation of IP3 receptor activity" NARROW [] +synonym: "up regulation of IP3 receptor activity" EXACT [] +synonym: "up-regulation of IP3 receptor activity" EXACT [] +synonym: "upregulation of IP3 receptor activity" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031585 ! regulation of inositol-1,4,5-triphosphate receptor activity + +[Term] +id: GO:0031588 +name: AMP-activated protein kinase complex +namespace: cellular_component +def: "A protein complex that possesses AMP-dependent protein kinase activity." [GOC:mah] +synonym: "5'-AMP-activated protein kinase complex" EXACT [] +synonym: "Snf1 kinase complex" NARROW [] +synonym: "Snf1 serine/threonine protein kinase complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031589 +name: cell-substrate adhesion +namespace: biological_process +def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] +subset: gosubset_prok +is_a: GO:0007155 ! cell adhesion + +[Term] +id: GO:0031590 +name: wybutosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037] +synonym: "wybutosine metabolism" EXACT [] +synonym: "yW metabolic process" EXACT [] +synonym: "yW metabolism" EXACT [] +is_a: GO:0008617 ! guanosine metabolic process + +[Term] +id: GO:0031591 +name: wybutosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037] +comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe. +synonym: "yW biosynthesis" EXACT [] +synonym: "yW biosynthetic process" EXACT [] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0031590 ! wybutosine metabolic process + +[Term] +id: GO:0031592 +name: centrosomal corona +namespace: cellular_component +def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah] +comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0031593 +name: polyubiquitin binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with a polymer of ubiqutin." [GOC:mah] +synonym: "multiubiquitin binding" RELATED [] +is_a: GO:0043130 ! ubiquitin binding + +[Term] +id: GO:0031594 +name: neuromuscular junction +namespace: cellular_component +def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction." [GOC:nln] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0031595 +name: nuclear proteasome complex +namespace: cellular_component +def: "A proteasome found in the nucleus of a cell." [GOC:mah] +is_a: GO:0000502 ! proteasome complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0031596 +name: ER proteasome complex +namespace: cellular_component +def: "A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0000502 ! proteasome complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0031597 +name: cytosolic proteasome complex +namespace: cellular_component +def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome complex (sensu Eukaryota)" EXACT [] +is_a: GO:0000502 ! proteasome complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0031598 +name: nuclear proteasome regulatory particle +namespace: cellular_component +def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0005838 ! proteasome regulatory particle +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031595 ! nuclear proteasome complex + +[Term] +id: GO:0031599 +name: ER proteasome regulatory particle +namespace: cellular_component +def: "The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0005838 ! proteasome regulatory particle +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031596 ! ER proteasome complex + +[Term] +id: GO:0031600 +name: cytosolic proteasome regulatory particle +namespace: cellular_component +def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome regulatory particle (sensu Eukaryota)" EXACT [] +is_a: GO:0005838 ! proteasome regulatory particle +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0031597 ! cytosolic proteasome complex + +[Term] +id: GO:0031601 +name: nuclear proteasome core complex +namespace: cellular_component +def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0005839 ! proteasome core complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031595 ! nuclear proteasome complex + +[Term] +id: GO:0031602 +name: ER proteasome core complex +namespace: cellular_component +def: "The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0005839 ! proteasome core complex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031596 ! ER proteasome complex + +[Term] +id: GO:0031603 +name: cytosolic proteasome core complex +namespace: cellular_component +def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome core complex (sensu Eukaryota)" EXACT [] +is_a: GO:0005839 ! proteasome core complex +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0031597 ! cytosolic proteasome complex + +[Term] +id: GO:0031604 +name: nuclear proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031601 ! nuclear proteasome core complex + +[Term] +id: GO:0031605 +name: ER proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031602 ! ER proteasome core complex + +[Term] +id: GO:0031606 +name: cytosolic proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome core complex, alpha-subunit complex (sensu Eukaryota)" EXACT [] +is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0031603 ! cytosolic proteasome core complex + +[Term] +id: GO:0031607 +name: nuclear proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0019774 ! proteasome core complex, beta-subunit complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031601 ! nuclear proteasome core complex + +[Term] +id: GO:0031608 +name: ER proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0019774 ! proteasome core complex, beta-subunit complex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031602 ! ER proteasome core complex + +[Term] +id: GO:0031609 +name: cytosolic proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome core complex, beta-subunit complex (sensu Eukaryota)" EXACT [] +is_a: GO:0019774 ! proteasome core complex, beta-subunit complex +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0031603 ! cytosolic proteasome core complex + +[Term] +id: GO:0031610 +name: nuclear proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle + +[Term] +id: GO:0031611 +name: ER proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031599 ! ER proteasome regulatory particle + +[Term] +id: GO:0031612 +name: cytosolic proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome regulatory particle, base subcomplex (sensu Eukaryota)" EXACT [] +is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle + +[Term] +id: GO:0031613 +name: nuclear proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle + +[Term] +id: GO:0031614 +name: ER proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0031599 ! ER proteasome regulatory particle + +[Term] +id: GO:0031615 +name: cytosolic proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome] +synonym: "cytosolic proteasome regulatory particle, lid subcomplex (sensu Eukaryota)" EXACT [] +is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex +is_a: GO:0044445 ! cytosolic part +relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle + +[Term] +id: GO:0031616 +name: spindle pole centrosome +namespace: cellular_component +def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] +is_a: GO:0005813 ! centrosome +relationship: part_of GO:0000922 ! spindle pole + +[Term] +id: GO:0031617 +name: NMS complex +namespace: cellular_component +def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914] +synonym: "Ndc80-MIND-Spc7 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0031618 +name: nuclear centromeric heterochromatin +namespace: cellular_component +def: "A region of heterochromatin located near the centromere of a chromosome in the nucleus." [GOC:mah] +synonym: "nuclear centric heterochromatin" EXACT [] +is_a: GO:0005720 ! nuclear heterochromatin +is_a: GO:0005721 ! centromeric heterochromatin + +[Term] +id: GO:0031619 +name: homologous chromosome orientation during meiosis +namespace: biological_process +def: "The cell cycle process whereby the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] +synonym: "homologous chromosome orientation during meiosis I" EXACT [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0043060 ! meiotic metaphase I plate congression + +[Term] +id: GO:0031620 +name: regulation of fever +namespace: biological_process +def: "Any process that modulates the rate or extent of fever." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of pyrexia" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0031650 ! regulation of heat generation +relationship: regulates GO:0001660 ! fever + +[Term] +id: GO:0031621 +name: negative regulation of fever +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of fever." [GOC:add, GOC:dph, GOC:tb] +synonym: "down regulation of fever" EXACT [] +synonym: "down-regulation of fever" EXACT [] +synonym: "downregulation of fever" EXACT [] +synonym: "inhibition of fever" NARROW [] +synonym: "negative regulation of pyrexia" EXACT [] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0031620 ! regulation of fever +is_a: GO:0031651 ! negative regulation of heat generation +relationship: negatively_regulates GO:0001660 ! fever + +[Term] +id: GO:0031622 +name: positive regulation of fever +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of fever." [GOC:add] +synonym: "activation of fever" NARROW [] +synonym: "positive regulation of pyrexia" EXACT [] +synonym: "stimulation of fever" NARROW [] +synonym: "up regulation of fever" EXACT [] +synonym: "up-regulation of fever" EXACT [] +synonym: "upregulation of fever" EXACT [] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0031620 ! regulation of fever +is_a: GO:0031652 ! positive regulation of heat generation +relationship: positively_regulates GO:0001660 ! fever + +[Term] +id: GO:0031623 +name: receptor internalization +namespace: biological_process +def: "The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling." [GOC:mah, PMID:15006537] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0031624 +name: ubiquitin conjugating enzyme binding +namespace: molecular_function +def: "Interacting selectively with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0031625 +name: ubiquitin protein ligase binding +namespace: molecular_function +def: "Interacting selectively with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] +synonym: "ubiquitin ligase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0031626 +name: beta-endorphin binding +namespace: molecular_function +def: "Interacting selectively with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560] +is_a: GO:0042165 ! neurotransmitter binding + +[Term] +id: GO:0031627 +name: telomeric loop formation +namespace: biological_process +def: "The process by which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214] +synonym: "t-loop biosynthesis" EXACT [] +synonym: "t-loop formation" EXACT [] +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0031628 +name: opioid receptor binding +namespace: molecular_function +def: "Interacting selectively with an opioid receptor." [GOC:nln] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031629 +name: synaptic vesicle fusion to presynaptic membrane +namespace: biological_process +def: "Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009] +synonym: "synaptic vesicle fusion" BROAD [] +synonym: "synaptic vesicle internalization" RELATED [] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0031630 +name: regulation of synaptic vesicle fusion to presynaptic membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:0046928 ! regulation of neurotransmitter secretion +relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane + +[Term] +id: GO:0031631 +name: negative regulation of synaptic vesicle fusion to presynaptic membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] +synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" NARROW [] +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane +relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane + +[Term] +id: GO:0031632 +name: positive regulation of synaptic vesicle fusion to presynaptic membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] +synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW [] +synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW [] +synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane +relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane + +[Term] +id: GO:0031633 +name: xanthophore +namespace: cellular_component +def: "A chromatophore containing yellow pigment." [ISBN:0395825172] +comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. +is_a: GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0031634 +name: replication fork barrier binding +namespace: molecular_function +def: "Interacting selectively with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0031635 +name: opioid receptor, adenylate cyclase inhibiting pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:mah] +is_a: GO:0007193 ! G-protein signaling, adenylate cyclase inhibiting pathway + +[Term] +id: GO:0031636 +name: adrenocorticotropin-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with adrenocorticotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0017047 ! adrenocorticotropin-releasing hormone binding + +[Term] +id: GO:0031637 +name: regulation of neuronal synaptic plasticity in response to neurotrophin +namespace: biological_process +def: "The process by which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078] +synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT [] +is_a: GO:0048168 ! regulation of neuronal synaptic plasticity + +[Term] +id: GO:0031638 +name: zymogen activation +namespace: biological_process +def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0031639 +name: plasminogen activation +namespace: biological_process +def: "The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds." [GOC:hjd] +is_a: GO:0031638 ! zymogen activation + +[Term] +id: GO:0031640 +name: killing of cells of another organism +namespace: biological_process +alt_id: GO:0001908 +def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] +subset: goslim_pir +subset: gosubset_prok +synonym: "killing of cells of another, non-host, organism" NARROW [] +is_a: GO:0001906 ! cell killing +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0031641 +name: regulation of myelination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0051960 ! regulation of nervous system development +is_a: GO:0051969 ! regulation of transmission of nerve impulse +relationship: regulates GO:0042552 ! myelination + +[Term] +id: GO:0031642 +name: negative regulation of myelination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] +synonym: "down regulation of myelination" EXACT [] +synonym: "down-regulation of myelination" EXACT [] +synonym: "downregulation of myelination" EXACT [] +synonym: "inhibition of myelination" NARROW [] +is_a: GO:0031641 ! regulation of myelination +is_a: GO:0031645 ! negative regulation of neurological system process +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0042552 ! myelination + +[Term] +id: GO:0031643 +name: positive regulation of myelination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] +synonym: "activation of myelination" NARROW [] +synonym: "stimulation of myelination" NARROW [] +synonym: "up regulation of myelination" EXACT [] +synonym: "up-regulation of myelination" EXACT [] +synonym: "upregulation of myelination" EXACT [] +is_a: GO:0031641 ! regulation of myelination +is_a: GO:0031646 ! positive regulation of neurological system process +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0042552 ! myelination + +[Term] +id: GO:0031644 +name: regulation of neurological system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of neurophysiological process" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0050877 ! neurological system process + +[Term] +id: GO:0031645 +name: negative regulation of neurological system process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of neurological process" EXACT [] +synonym: "down-regulation of neurological process" EXACT [] +synonym: "downregulation of neurological process" EXACT [] +synonym: "inhibition of neurological process" NARROW [] +synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of neurophysiological process" EXACT [] +is_a: GO:0031644 ! regulation of neurological system process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0050877 ! neurological system process + +[Term] +id: GO:0031646 +name: positive regulation of neurological system process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of neurological process" NARROW [] +synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of neurophysiological process" EXACT [] +synonym: "stimulation of neurological process" NARROW [] +synonym: "up regulation of neurological process" EXACT [] +synonym: "up-regulation of neurological process" EXACT [] +synonym: "upregulation of neurological process" EXACT [] +is_a: GO:0031644 ! regulation of neurological system process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0050877 ! neurological system process + +[Term] +id: GO:0031647 +name: regulation of protein stability +namespace: biological_process +def: "Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0031648 +name: protein destabilization +namespace: biological_process +def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] +synonym: "negative regulation of protein stability" EXACT [] +is_a: GO:0031647 ! regulation of protein stability + +[Term] +id: GO:0031649 +name: heat generation +namespace: biological_process +def: "Any homeostatic process by which an organism produces heat, thereby raising its internal temperature." [GOC:mah] +is_a: GO:0001659 ! temperature homeostasis + +[Term] +id: GO:0031650 +name: regulation of heat generation +namespace: biological_process +def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0031649 ! heat generation + +[Term] +id: GO:0031651 +name: negative regulation of heat generation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of heat generation" EXACT [] +synonym: "down-regulation of heat generation" EXACT [] +synonym: "downregulation of heat generation" EXACT [] +synonym: "inhibition of heat generation" NARROW [] +is_a: GO:0031650 ! regulation of heat generation +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0031649 ! heat generation + +[Term] +id: GO:0031652 +name: positive regulation of heat generation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of heat generation" NARROW [] +synonym: "stimulation of heat generation" NARROW [] +synonym: "up regulation of heat generation" EXACT [] +synonym: "up-regulation of heat generation" EXACT [] +synonym: "upregulation of heat generation" EXACT [] +is_a: GO:0031650 ! regulation of heat generation +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0031649 ! heat generation + +[Term] +id: GO:0031653 +name: heat dissipation +namespace: biological_process +def: "Any homeostatic process by which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah] +is_a: GO:0001659 ! temperature homeostasis + +[Term] +id: GO:0031654 +name: regulation of heat dissipation +namespace: biological_process +def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0031653 ! heat dissipation + +[Term] +id: GO:0031655 +name: negative regulation of heat dissipation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of heat dissipation" EXACT [] +synonym: "down-regulation of heat dissipation" EXACT [] +synonym: "downregulation of heat dissipation" EXACT [] +synonym: "inhibition of heat dissipation" NARROW [] +is_a: GO:0031654 ! regulation of heat dissipation +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0031653 ! heat dissipation + +[Term] +id: GO:0031656 +name: positive regulation of heat dissipation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of heat dissipation" NARROW [] +synonym: "stimulation of heat dissipation" NARROW [] +synonym: "up regulation of heat dissipation" EXACT [] +synonym: "up-regulation of heat dissipation" EXACT [] +synonym: "upregulation of heat dissipation" EXACT [] +is_a: GO:0031654 ! regulation of heat dissipation +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0031653 ! heat dissipation + +[Term] +id: GO:0031657 +name: G1/S-specific regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah] +is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity +relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle + +[Term] +id: GO:0031658 +name: G1/S-specific negative regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah] +synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] +is_a: GO:0031657 ! G1/S-specific regulation of cyclin-dependent protein kinase activity +is_a: GO:0045736 ! negative regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0031659 +name: G1/S-specific positive regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah] +synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] +is_a: GO:0031657 ! G1/S-specific regulation of cyclin-dependent protein kinase activity +is_a: GO:0045737 ! positive regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0031660 +name: G2/M-specific regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah] +is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity +relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0031661 +name: G2/M-specific negative regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah] +synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] +is_a: GO:0031660 ! G2/M-specific regulation of cyclin-dependent protein kinase activity +is_a: GO:0045736 ! negative regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0031662 +name: G2/M-specific positive regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:mah] +synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] +is_a: GO:0031660 ! G2/M-specific regulation of cyclin-dependent protein kinase activity +is_a: GO:0045737 ! positive regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0031663 +name: lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "LPS-mediated signaling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0031664 +name: regulation of lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "regulation of LPS-mediated signaling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway + +[Term] +id: GO:0031665 +name: negative regulation of lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW [] +synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "negative regulation of LPS-mediated signaling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway +relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway + +[Term] +id: GO:0031666 +name: positive regulation of lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW [] +synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "positive regulation of LPS-mediated signaling pathway" EXACT [] +synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW [] +synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway +relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway + +[Term] +id: GO:0031667 +name: response to nutrient levels +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] +subset: gosubset_prok +is_a: GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0031668 +name: cellular response to extracellular stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] +subset: gosubset_prok +is_a: GO:0007154 ! cell communication +is_a: GO:0009991 ! response to extracellular stimulus +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0031669 +name: cellular response to nutrient levels +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0031670 +name: cellular response to nutrient +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah] +is_a: GO:0007584 ! response to nutrient +is_a: GO:0031669 ! cellular response to nutrient levels + +[Term] +id: GO:0031671 +name: primary cell septum biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the constituents of the primary cell septum following nuclear division." [GOC:mah] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000917 ! barrier septum formation + +[Term] +id: GO:0031672 +name: A band +namespace: cellular_component +def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] +synonym: "A disc" EXACT [] +synonym: "anisotropic disc" EXACT [] +synonym: "Q disc" EXACT [] +synonym: "transverse disc" EXACT [] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0031673 +name: H zone +namespace: cellular_component +def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] +synonym: "H band" EXACT [] +synonym: "H disc" EXACT [] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0031672 ! A band + +[Term] +id: GO:0031674 +name: I band +namespace: cellular_component +def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] +synonym: "I disc" EXACT [] +synonym: "isotropic disc" EXACT [] +synonym: "J disc" EXACT [] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0031676 +name: plasma membrane-derived thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] +synonym: "plasma membrane thylakoid membrane" EXACT [] +synonym: "thylakoid membrane (sensu Cyanobacteria)" EXACT [] +is_a: GO:0042651 ! thylakoid membrane +is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid + +[Term] +id: GO:0031679 +name: NADH dehydrogenase (plastoquinone) activity +namespace: molecular_function +alt_id: GO:0030024 +def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah] +synonym: "NADH:plastoquinone reductase activity" EXACT [] +is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity + +[Term] +id: GO:0031680 +name: G-protein beta/gamma-subunit complex +namespace: cellular_component +def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah] +comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. +synonym: "G-beta/G-gamma complex" EXACT [] +synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0031681 +name: G-protein beta-subunit binding +namespace: molecular_function +def: "Interacting selectively with a G-protein beta subunit." [GOC:mah] +synonym: "G-beta protein subunit binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031682 +name: G-protein gamma-subunit binding +namespace: molecular_function +def: "Interacting selectively with a G-protein gamma subunit." [GOC:mah] +synonym: "G-gamma protein subunit binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031683 +name: G-protein beta/gamma-subunit binding +namespace: molecular_function +def: "Interacting selectively with a complex of G-protein beta/gamma subunits." [GOC:nln] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0031684 +name: heterotrimeric G-protein complex cycle +namespace: biological_process +def: "The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln] +is_a: GO:0043087 ! regulation of GTPase activity +relationship: part_of GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0031685 +name: adenosine receptor binding +namespace: molecular_function +def: "Interacting selectively with an adenosine receptor." [GOC:mah, GOC:nln] +synonym: "adenosine receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031686 +name: A1 adenosine receptor binding +namespace: molecular_function +def: "Interacting selectively with an A1 adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A1 adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031687 +name: A2A adenosine receptor binding +namespace: molecular_function +def: "Interacting selectively with an A2A adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A2A adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031688 +name: A2B adenosine receptor binding +namespace: molecular_function +def: "Interacting selectively with an A2B adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A2B adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031689 +name: A3 adenosine receptor binding +namespace: molecular_function +def: "Interacting selectively with an A3 adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A3 adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031690 +name: adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "adrenergic receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031691 +name: alpha-1A adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-1A adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031692 +name: alpha-1B adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-1B adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031693 +name: alpha-1D adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-1D adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031694 +name: alpha-2A adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-2A adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031695 +name: alpha-2B adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-2B adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031696 +name: alpha-2C adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-2C adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031697 +name: beta-1 adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "beta-1 adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031698 +name: beta-2 adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "beta-2 adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031699 +name: beta-3 adrenergic receptor binding +namespace: molecular_function +def: "Interacting selectively with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "beta-3 adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031700 +name: adrenomedullin receptor binding +namespace: molecular_function +def: "Interacting selectively with an adrenomedullin receptor." [GOC:mah, GOC:nln] +synonym: "adrenomedullin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031701 +name: angiotensin receptor binding +namespace: molecular_function +def: "Interacting selectively with an angiotensin receptor." [GOC:mah, GOC:nln] +synonym: "angiotensin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031702 +name: type 1 angiotensin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 angiotensin receptor." [GOC:mah, GOC:nln] +synonym: "AT1 receptor binding" EXACT [] +synonym: "type 1 angiotensin receptor ligand" NARROW [] +is_a: GO:0031701 ! angiotensin receptor binding + +[Term] +id: GO:0031703 +name: type 2 angiotensin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 angiotensin receptor." [GOC:mah, GOC:nln] +synonym: "AT2 receptor binding" EXACT [] +synonym: "type 2 angiotensin receptor ligand" NARROW [] +is_a: GO:0031701 ! angiotensin receptor binding + +[Term] +id: GO:0031704 +name: apelin receptor binding +namespace: molecular_function +alt_id: GO:0042569 +def: "Interacting selectively with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050] +synonym: "apelin receptor ligand" NARROW [] +synonym: "APJ receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031705 +name: bombesin receptor binding +namespace: molecular_function +def: "Interacting selectively with a bombesin receptor." [GOC:mah, GOC:nln] +synonym: "bombesin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031706 +name: subtype 3 bombesin receptor binding +namespace: molecular_function +def: "Interacting selectively with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln] +synonym: "subtype 3 bombesin receptor ligand" NARROW [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031707 +name: endothelin A receptor binding +namespace: molecular_function +def: "Interacting selectively with an endothelin A receptor." [GOC:mah, GOC:nln] +synonym: "endothelin A receptor ligand" NARROW [] +synonym: "endothelin-1 receptor binding" EXACT [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031708 +name: endothelin B receptor binding +namespace: molecular_function +def: "Interacting selectively with an endothelin B receptor." [GOC:mah, GOC:nln] +synonym: "endothelin B receptor ligand" NARROW [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031709 +name: gastrin-releasing peptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln] +synonym: "gastrin-releasing peptide receptor ligand" NARROW [] +synonym: "GRP receptor binding" EXACT [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031710 +name: neuromedin B receptor binding +namespace: molecular_function +def: "Interacting selectively with a neuromedin B receptor." [GOC:mah, GOC:nln] +synonym: "neuromedin B receptor ligand" NARROW [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031711 +name: bradykinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a bradykinin receptor." [GOC:mah, GOC:nln] +synonym: "bradykinin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031712 +name: B1 bradykinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a B1 bradykinin receptor." [GOC:mah, GOC:nln] +synonym: "B1 bradykinin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031713 +name: B2 bradykinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a B2 bradykinin receptor." [GOC:mah, GOC:nln] +synonym: "B2 bradykinin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031714 +name: C5a anaphylatoxin chemotactic receptor binding +namespace: molecular_function +def: "Interacting selectively with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] +synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031715 +name: C5L2 anaphylatoxin chemotactic receptor binding +namespace: molecular_function +def: "Interacting selectively with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] +synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW [] +is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding + +[Term] +id: GO:0031716 +name: calcitonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a calcitonin receptor." [GOC:mah, GOC:nln] +synonym: "calcitonin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031717 +name: cannabinoid receptor binding +namespace: molecular_function +def: "Interacting selectively with a cannabinoid receptor." [GOC:mah, GOC:nln] +synonym: "cannabinoid receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031718 +name: type 1 cannabinoid receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln] +synonym: "type 1 cannabinoid receptor ligand" NARROW [] +is_a: GO:0031717 ! cannabinoid receptor binding + +[Term] +id: GO:0031719 +name: type 2 cannabinoid receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln] +synonym: "type 2 cannabinoid receptor ligand" NARROW [] +is_a: GO:0031717 ! cannabinoid receptor binding + +[Term] +id: GO:0031720 +name: haptoglobin binding +namespace: molecular_function +def: "Interacting selectively with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031721 +name: hemoglobin alpha binding +namespace: molecular_function +def: "Interacting selectively with a hemoglobin alpha chain." [GOC:mah] +is_a: GO:0030492 ! hemoglobin binding + +[Term] +id: GO:0031722 +name: hemoglobin beta binding +namespace: molecular_function +def: "Interacting selectively with a hemoglobin beta chain." [GOC:mah] +is_a: GO:0030492 ! hemoglobin binding + +[Term] +id: GO:0031723 +name: CXCR4 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CXCR4 chemokine receptor ligand" NARROW [] +synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0031724 +name: CXCR5 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CXCR5 chemokine receptor ligand" NARROW [] +synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0031725 +name: CXCR6 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "bonzo receptor binding" EXACT [] +synonym: "CXCR6 chemokine receptor ligand" NARROW [] +synonym: "STRL33 receptor binding" EXACT [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0031726 +name: CCR1 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR1 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR1 chemokine receptor ligand" NARROW [] +synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031727 +name: CCR2 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR2 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR2 chemokine receptor ligand" NARROW [] +synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031728 +name: CCR3 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR3 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR3 chemokine receptor ligand" NARROW [] +synonym: "eosinophil eotaxin receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031729 +name: CCR4 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR4 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR4 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031730 +name: CCR5 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR5 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR5 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031731 +name: CCR6 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR6 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR6 chemokine receptor ligand" NARROW [] +synonym: "LARC receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031732 +name: CCR7 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR7 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR7 chemokine receptor ligand" NARROW [] +synonym: "MIP-3 beta receptor binding" EXACT [] +synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031733 +name: CCR8 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR8 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR8 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031734 +name: CCR9 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR9 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR9 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031735 +name: CCR10 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR10 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR10 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031736 +name: CCR11 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR11 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR11 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031737 +name: CX3C chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CX3C chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CX3C chemokine receptor ligand" NARROW [] +synonym: "fractalkine receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031738 +name: XCR1 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a XCR1 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "lymphotactin receptor binding" EXACT [] +synonym: "XCR1 chemokine receptor ligand" NARROW [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0031739 +name: cholecystokinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a cholecystokinin receptor." [GOC:mah, GOC:nln] +synonym: "cholecystokinin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031740 +name: type A cholecystokinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type A cholecystokinin receptor." [GOC:mah, GOC:nln] +synonym: "type A cholecystokinin receptor ligand" NARROW [] +is_a: GO:0031739 ! cholecystokinin receptor binding + +[Term] +id: GO:0031741 +name: type B gastrin/cholecystokinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln] +synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW [] +is_a: GO:0031739 ! cholecystokinin receptor binding + +[Term] +id: GO:0031742 +name: corticotropin releasing factor receptor binding +namespace: molecular_function +def: "Interacting selectively with a corticotropin releasing factor receptor." [GOC:mah, GOC:nln] +synonym: "corticotropin releasing factor receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031743 +name: type 1 corticotropin releasing factor receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 corticotropin releasing factor receptor." [GOC:mah, GOC:nln] +synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW [] +is_a: GO:0031742 ! corticotropin releasing factor receptor binding + +[Term] +id: GO:0031744 +name: type 2 corticotropin releasing factor receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 corticotropin releasing factor receptor." [GOC:mah, GOC:nln] +synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW [] +is_a: GO:0031742 ! corticotropin releasing factor receptor binding + +[Term] +id: GO:0031745 +name: cysteinyl leukotriene receptor binding +namespace: molecular_function +def: "Interacting selectively with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "cysteinyl leukotriene receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031746 +name: type 1 cysteinyl leukotriene receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW [] +is_a: GO:0031745 ! cysteinyl leukotriene receptor binding + +[Term] +id: GO:0031747 +name: type 2 cysteinyl leukotriene receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW [] +is_a: GO:0031745 ! cysteinyl leukotriene receptor binding + +[Term] +id: GO:0031748 +name: D1 dopamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a D1 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D1 dopamine receptor ligand" NARROW [] +synonym: "D1A dopamine receptor binding" EXACT [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031749 +name: D2 dopamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a D2 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D2 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031750 +name: D3 dopamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a D3 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D3 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031751 +name: D4 dopamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a D4 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D4 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031752 +name: D5 dopamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a D5 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D1B dopamine receptor binding" EXACT [] +synonym: "D5 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031753 +name: endothelial differentiation G-protein coupled receptor binding +namespace: molecular_function +def: "Interacting selectively with an endothelial differentiation G-protein coupled receptor." [GOC:mah, GOC:nln] +synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031754 +name: Edg-1 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031755 +name: Edg-2 lysophosphatidic acid receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] +synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW [] +synonym: "LPA1 receptor binding" EXACT [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031756 +name: Edg-3 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031757 +name: Edg-4 lysophosphatidic acid receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] +synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW [] +synonym: "LPA2 receptor binding" EXACT [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031758 +name: Edg-5 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031759 +name: Edg-6 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031760 +name: Edg-7 lysophosphatidic acid receptor binding +namespace: molecular_function +def: "Interacting selectively with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] +synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW [] +synonym: "LPA3 receptor binding" EXACT [] +is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding + +[Term] +id: GO:0031761 +name: fMet-Leu-Phe receptor binding +namespace: molecular_function +def: "Interacting selectively with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] +synonym: "fMet-Leu-Phe receptor ligand" NARROW [] +synonym: "N-formyl peptide receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031762 +name: follicle stimulating hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a follicle stimulating hormone receptor." [GOC:mah, GOC:nln] +synonym: "follicle stimulating hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031763 +name: galanin receptor binding +namespace: molecular_function +def: "Interacting selectively with a galanin receptor." [GOC:mah, GOC:nln] +synonym: "galanin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031764 +name: type 1 galanin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 galanin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 galanin receptor ligand" NARROW [] +is_a: GO:0031763 ! galanin receptor binding + +[Term] +id: GO:0031765 +name: type 2 galanin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 galanin receptor." [GOC:mah, GOC:nln] +synonym: "type 2 galanin receptor ligand" NARROW [] +is_a: GO:0031763 ! galanin receptor binding + +[Term] +id: GO:0031766 +name: type 3 galanin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 3 galanin receptor." [GOC:mah, GOC:nln] +synonym: "type 3 galanin receptor ligand" NARROW [] +is_a: GO:0031763 ! galanin receptor binding + +[Term] +id: GO:0031767 +name: gastric inhibitory polypeptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "gastric inhibitory polypeptide receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031768 +name: ghrelin receptor binding +namespace: molecular_function +def: "Interacting selectively with a ghrelin receptor." [GOC:mah, GOC:nln] +synonym: "ghrelin receptor ligand" NARROW [] +synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031769 +name: glucagon receptor binding +namespace: molecular_function +def: "Interacting selectively with a glucagon receptor." [GOC:mah, GOC:nln] +synonym: "glucagon receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031770 +name: growth hormone-releasing hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln] +synonym: "growth hormone-releasing hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031771 +name: type 1 hypocretin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 hypocretin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 hypocretin receptor ligand" NARROW [] +synonym: "type 1 orexin receptor binding" EXACT [] +is_a: GO:0042324 ! hypocretin receptor binding + +[Term] +id: GO:0031772 +name: type 2 hypocretin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 hypocretin receptor." [GOC:mah, GOC:nln] +synonym: "type 2 hypocretin receptor ligand" NARROW [] +synonym: "type 2 orexin receptor binding" EXACT [] +is_a: GO:0042324 ! hypocretin receptor binding + +[Term] +id: GO:0031773 +name: kisspeptin receptor binding +namespace: molecular_function +def: "Interacting selectively with a kisspeptin receptor." [GOC:mah, GOC:nln] +synonym: "G-protein coupled receptor 54 binding" EXACT [] +synonym: "hOT7T175 receptor binding" EXACT [] +synonym: "hypogonadotropin-1 receptor binding" EXACT [] +synonym: "KiSS-1 receptor binding" EXACT [] +synonym: "kisspeptin receptor ligand" NARROW [] +synonym: "metastin receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031774 +name: leukotriene receptor binding +namespace: molecular_function +def: "Interacting selectively with a leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "leukotriene receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031775 +name: lutropin-choriogonadotropic hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln] +synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031776 +name: melanin-concentrating hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] +synonym: "melanin-concentrating hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031777 +name: type 1 melanin-concentrating hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] +synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW [] +is_a: GO:0031776 ! melanin-concentrating hormone receptor binding + +[Term] +id: GO:0031778 +name: type 2 melanin-concentrating hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] +synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW [] +is_a: GO:0031776 ! melanin-concentrating hormone receptor binding + +[Term] +id: GO:0031779 +name: melanocortin receptor binding +namespace: molecular_function +def: "Interacting selectively with a melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "melanocortin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031780 +name: adrenocorticotropin hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with an adrenocorticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln] +synonym: "ACTH receptor binding" EXACT [] +synonym: "adrenocorticotropic hormone receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031781 +name: type 3 melanocortin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 3 melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "type 3 melanocortin receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031782 +name: type 4 melanocortin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 4 melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "type 4 melanocortin receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031783 +name: type 5 melanocortin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 5 melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "type 5 melanocortin receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031784 +name: melatonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a melatonin receptor." [GOC:mah, GOC:nln] +synonym: "melatonin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031785 +name: type 1A melatonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1A melatonin receptor." [GOC:mah, GOC:nln] +synonym: "type 1A melatonin receptor ligand" NARROW [] +is_a: GO:0031784 ! melatonin receptor binding + +[Term] +id: GO:0031786 +name: type 1B melatonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1B melatonin receptor." [GOC:mah, GOC:nln] +synonym: "type 1B melatonin receptor ligand" NARROW [] +is_a: GO:0031784 ! melatonin receptor binding + +[Term] +id: GO:0031787 +name: H9 melatonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a H9 melatonin receptor." [GOC:mah, GOC:nln] +synonym: "H9 melatonin receptor ligand" NARROW [] +is_a: GO:0031784 ! melatonin receptor binding + +[Term] +id: GO:0031788 +name: motilin receptor binding +namespace: molecular_function +def: "Interacting selectively with a motilin receptor." [GOC:mah, GOC:nln] +synonym: "motilin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031789 +name: muscarinic acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with a muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] +synonym: "muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031790 +name: M1 muscarinic acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with a M1 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] +synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0031789 ! muscarinic acetylcholine receptor binding + +[Term] +id: GO:0031791 +name: M2 muscarinic acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with a M2 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] +synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0031789 ! muscarinic acetylcholine receptor binding + +[Term] +id: GO:0031792 +name: M3 muscarinic acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with a M3 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] +synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0031789 ! muscarinic acetylcholine receptor binding + +[Term] +id: GO:0031793 +name: M4 muscarinic acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with a M4 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] +synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0031789 ! muscarinic acetylcholine receptor binding + +[Term] +id: GO:0031794 +name: M5 muscarinic acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with a M5 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln] +synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0031789 ! muscarinic acetylcholine receptor binding + +[Term] +id: GO:0031795 +name: metabotropic GABA receptor binding +namespace: molecular_function +def: "Interacting selectively with a metabotropic GABA receptor." [GOC:mah, GOC:nln] +synonym: "GABAB receptor binding" EXACT [] +synonym: "metabotropic GABA receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031796 +name: type 1 metabotropic GABA receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln] +synonym: "type 1 metabotropic GABA receptor ligand" NARROW [] +is_a: GO:0031795 ! metabotropic GABA receptor binding + +[Term] +id: GO:0031797 +name: type 2 metabotropic GABA receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln] +synonym: "type 2 metabotropic GABA receptor ligand" NARROW [] +is_a: GO:0031795 ! metabotropic GABA receptor binding + +[Term] +id: GO:0031798 +name: type 1 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 1 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031799 +name: type 2 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 2 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031800 +name: type 3 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 3 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031801 +name: type 4 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 4 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031802 +name: type 5 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 5 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031803 +name: type 6 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 6 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031804 +name: type 7 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 7 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031805 +name: type 8 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 8 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! metabotropic glutatmate receptor binding + +[Term] +id: GO:0031806 +name: metabotropic histamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a metabotropic histamine receptor." [GOC:mah, GOC:nln] +synonym: "metabotropic histamine receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031807 +name: H1 histamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a H1 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H1 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! metabotropic histamine receptor binding + +[Term] +id: GO:0031808 +name: H2 histamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a H2 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H2 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! metabotropic histamine receptor binding + +[Term] +id: GO:0031809 +name: H3 histamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a H3 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H3 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! metabotropic histamine receptor binding + +[Term] +id: GO:0031810 +name: H4 histamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a H4 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H4 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! metabotropic histamine receptor binding + +[Term] +id: GO:0031811 +name: metabotropic nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a metabotropic nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "metabotropic nucleotide receptor ligand" NARROW [] +synonym: "P2Y receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031812 +name: P2Y1 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y1 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031813 +name: P2Y2 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y2 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031814 +name: P2Y4 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y4 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031815 +name: P2Y5 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y5 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031816 +name: P2Y6 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y6 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031817 +name: P2Y8 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y8 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031818 +name: P2Y9 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y9 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031819 +name: P2Y10 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y10 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031820 +name: P2Y11 nucleotide receptor binding +namespace: molecular_function +def: "Interacting selectively with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y11 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! metabotropic nucleotide receptor binding + +[Term] +id: GO:0031821 +name: metabotropic serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a metabotropic serotonin receptor." [GOC:mah, GOC:nln] +synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT [] +synonym: "metabotropic serotonin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031822 +name: type 1B serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1B serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1B receptor binding" EXACT [] +synonym: "type 1B serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031823 +name: type 1D serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1D serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1D receptor binding" EXACT [] +synonym: "type 1D serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031824 +name: type 1E serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1E serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1E receptor binding" EXACT [] +synonym: "type 1E serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031825 +name: type 1F serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1F serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1F receptor binding" EXACT [] +synonym: "type 1F serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031826 +name: type 2A serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2A serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 2A receptor binding" EXACT [] +synonym: "type 2A serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031827 +name: type 2B serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2B serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 2B receptor binding" EXACT [] +synonym: "type 2B serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031828 +name: type 2C serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2C serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 2C receptor binding" EXACT [] +synonym: "type 2C serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031829 +name: type 4 serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 4 serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 4 receptor binding" EXACT [] +synonym: "type 4 serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031830 +name: type 5A serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 5A serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 5A receptor binding" EXACT [] +synonym: "type 5A serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031831 +name: type 5B serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 5B serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 5B receptor binding" EXACT [] +synonym: "type 5B serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031832 +name: type 6 serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 6 serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 6 receptor binding" EXACT [] +synonym: "type 6 serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031833 +name: type 7 serotonin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 7 serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 7 receptor binding" EXACT [] +synonym: "type 7 serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! metabotropic serotonin receptor binding + +[Term] +id: GO:0031834 +name: neurokinin receptor binding +namespace: molecular_function +def: "Interacting selectively with a neurokinin receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031835 +name: substance P receptor binding +namespace: molecular_function +def: "Interacting selectively with a substance P receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin-1 receptor binding" EXACT [] +synonym: "substance P receptor ligand" NARROW [] +is_a: GO:0031834 ! neurokinin receptor binding + +[Term] +id: GO:0031836 +name: neuromedin K receptor binding +namespace: molecular_function +def: "Interacting selectively with a neuromedin K receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin-B receptor binding" EXACT [] +synonym: "neuromedin K receptor ligand" NARROW [] +is_a: GO:0031834 ! neurokinin receptor binding + +[Term] +id: GO:0031837 +name: substance K receptor binding +namespace: molecular_function +def: "Interacting selectively with a substance K receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin-A receptor binding" EXACT [] +synonym: "substance K receptor ligand" NARROW [] +is_a: GO:0031834 ! neurokinin receptor binding + +[Term] +id: GO:0031838 +name: haptoglobin-hemoglobin complex +namespace: cellular_component +def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0031839 +name: type 1 neuromedin U receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln] +synonym: "type 1 neuromedin U receptor ligand" NARROW [] +is_a: GO:0042922 ! neuromedin U receptor binding + +[Term] +id: GO:0031840 +name: type 2 neuromedin U receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln] +synonym: "type 2 neuromedin U receptor ligand" NARROW [] +is_a: GO:0042922 ! neuromedin U receptor binding + +[Term] +id: GO:0031841 +name: neuropeptide Y receptor binding +namespace: molecular_function +def: "Interacting selectively with a neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "neuropeptide Y receptor ligand" NARROW [] +synonym: "NPY receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031842 +name: type 1 neuropeptide Y receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "type 1 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031843 +name: type 2 neuropeptide Y receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "type 2 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031844 +name: type 4 neuropeptide Y receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "pancreatic polypeptide receptor binding" EXACT [] +synonym: "type 4 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031845 +name: type 5 neuropeptide Y receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "type 5 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031846 +name: neurotensin receptor binding +namespace: molecular_function +def: "Interacting selectively with a neurotensin receptor." [GOC:mah, GOC:nln] +synonym: "neurotensin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031847 +name: type 1 neurotensin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 neurotensin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 neurotensin receptor ligand" NARROW [] +is_a: GO:0031846 ! neurotensin receptor binding + +[Term] +id: GO:0031848 +name: protection from non-homologous end joining at telomere +namespace: biological_process +def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah] +synonym: "protection from NHEJ-mediated telomere fusion" EXACT [] +is_a: GO:0043247 ! telomere maintenance in response to DNA damage +relationship: part_of GO:0016233 ! telomere capping + +[Term] +id: GO:0031849 +name: olfactory receptor binding +namespace: molecular_function +def: "Interacting selectively with an olfactory receptor." [GOC:mah, GOC:nln] +synonym: "olfactory receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031850 +name: delta-type opioid receptor binding +namespace: molecular_function +def: "Interacting selectively with a delta-type opioid receptor." [GOC:mah, GOC:nln] +synonym: "delta-type opioid receptor ligand" NARROW [] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031851 +name: kappa-type opioid receptor binding +namespace: molecular_function +def: "Interacting selectively with a kappa-type opioid receptor." [GOC:mah, GOC:nln] +synonym: "kappa-type opioid receptor ligand" NARROW [] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031852 +name: mu-type opioid receptor binding +namespace: molecular_function +def: "Interacting selectively with a mu-type opioid receptor." [GOC:mah, GOC:nln] +synonym: "mu-type opioid receptor ligand" NARROW [] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031853 +name: nociceptin receptor binding +namespace: molecular_function +def: "Interacting selectively with a nociceptin receptor." [GOC:mah, GOC:nln] +synonym: "nociceptin receptor ligand" NARROW [] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031854 +name: orexigenic neuropeptide QRFP receptor binding +namespace: molecular_function +def: "Interacting selectively with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln] +synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031855 +name: oxytocin receptor binding +namespace: molecular_function +def: "Interacting selectively with an oxytocin receptor." [GOC:mah, GOC:nln] +synonym: "oxytocin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031856 +name: parathyroid hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a parathyroid hormone receptor." [GOC:mah, GOC:nln] +synonym: "parathyroid hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031857 +name: type 1 parathyroid hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln] +synonym: "type 1 parathyroid hormone receptor ligand" NARROW [] +is_a: GO:0031856 ! parathyroid hormone receptor binding + +[Term] +id: GO:0031858 +name: pituitary adenylate cyclase-activating peptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a pituitary adenylate cyclase-activating peptide receptor." [GOC:mah, GOC:nln] +synonym: "PACAP receptor binding" EXACT [] +synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031859 +name: platelet activating factor receptor binding +namespace: molecular_function +def: "Interacting selectively with a platelet activating factor receptor." [GOC:mah, GOC:nln] +synonym: "platelet activating factor receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031860 +name: telomeric 3' overhang formation +namespace: biological_process +def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] +is_a: GO:0022616 ! DNA strand elongation +relationship: part_of GO:0016233 ! telomere capping + +[Term] +id: GO:0031861 +name: prolactin-releasing peptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln] +synonym: "prolactin-releasing peptide receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031862 +name: prostanoid receptor binding +namespace: molecular_function +def: "Interacting selectively with a prostanoid receptor." [GOC:mah, GOC:nln] +synonym: "prostanoid receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031863 +name: prostaglandin D2 receptor binding +namespace: molecular_function +def: "Interacting selectively with a prostaglandin D2 receptor." [GOC:mah, GOC:nln] +synonym: "prostaglandin D2 receptor ligand" NARROW [] +synonym: "prostanoid DP receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031864 +name: EP1 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Interacting selectively with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP1 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031865 +name: EP2 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Interacting selectively with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP2 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031866 +name: EP3 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Interacting selectively with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP3 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031867 +name: EP4 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Interacting selectively with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP4 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031868 +name: prostaglandin F2-alpha receptor binding +namespace: molecular_function +def: "Interacting selectively with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln] +synonym: "prostaglandin F2-alpha receptor ligand" NARROW [] +synonym: "prostanoid FP receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031869 +name: prostacyclin receptor binding +namespace: molecular_function +def: "Interacting selectively with a prostacyclin receptor." [GOC:mah, GOC:nln] +synonym: "prostacyclin receptor ligand" NARROW [] +synonym: "prostanoid IP receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031870 +name: thromboxane A2 receptor binding +namespace: molecular_function +def: "Interacting selectively with a thromboxane A2 receptor." [GOC:mah, GOC:nln] +synonym: "prostanoid TP receptor binding" EXACT [] +synonym: "thromboxane A2 receptor ligand" NARROW [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031871 +name: proteinase activated receptor binding +namespace: molecular_function +def: "Interacting selectively with a proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "proteinase activated receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031872 +name: type 1 proteinase activated receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "thrombin receptor binding" EXACT [] +synonym: "type 1 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031873 +name: type 2 proteinase activated receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "type 2 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031874 +name: type 3 proteinase activated receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "type 3 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031875 +name: type 4 proteinase activated receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "type 4 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031876 +name: secretin receptor binding +namespace: molecular_function +def: "Interacting selectively with a secretin receptor." [GOC:mah, GOC:nln] +synonym: "secretin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031877 +name: somatostatin receptor binding +namespace: molecular_function +def: "Interacting selectively with a somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "somatostatin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031878 +name: type 1 somatostatin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031879 +name: type 2 somatostatin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 2 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031880 +name: type 3 somatostatin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 3 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 3 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031881 +name: type 4 somatostatin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 4 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 4 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031882 +name: type 5 somatostatin receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 5 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 5 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031883 +name: taste receptor binding +namespace: molecular_function +def: "Interacting selectively with a taste receptor." [GOC:mah, GOC:nln] +synonym: "taste receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031884 +name: type 1 member 1 taste receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln] +synonym: "type 1 member 1 taste receptor ligand" NARROW [] +is_a: GO:0031883 ! taste receptor binding + +[Term] +id: GO:0031885 +name: type 1 member 2 taste receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln] +synonym: "type 1 member 2 taste receptor ligand" NARROW [] +is_a: GO:0031883 ! taste receptor binding + +[Term] +id: GO:0031886 +name: type 1 member 3 taste receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln] +synonym: "sweet taste receptor binding" EXACT [] +synonym: "type 1 member 3 taste receptor ligand" NARROW [] +is_a: GO:0031883 ! taste receptor binding + +[Term] +id: GO:0031887 +name: lipid particle transport along microtubule +namespace: biological_process +def: "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0031889 +name: urotensin receptor binding +namespace: molecular_function +def: "Interacting selectively with a urotensin receptor." [GOC:mah, GOC:nln] +synonym: "urotensin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031890 +name: vasoactive intestinal polypeptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW [] +synonym: "VIP receptor binding" EXACT [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031891 +name: type 1 vasoactive intestinal polypeptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW [] +synonym: "type 2 PACAP receptor binding" EXACT [] +is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding + +[Term] +id: GO:0031892 +name: type 2 vasoactive intestinal polypeptide receptor binding +namespace: molecular_function +def: "Interacting selectively with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW [] +synonym: "type 3 PACAP receptor binding" EXACT [] +is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding + +[Term] +id: GO:0031893 +name: vasopressin receptor binding +namespace: molecular_function +def: "Interacting selectively with a vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "vasopressin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0031894 +name: V1A vasopressin receptor binding +namespace: molecular_function +def: "Interacting selectively with a V1A vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "V1A vasopressin receptor ligand" NARROW [] +is_a: GO:0031893 ! vasopressin receptor binding + +[Term] +id: GO:0031895 +name: V1B vasopressin receptor binding +namespace: molecular_function +def: "Interacting selectively with a V1B vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "V1B vasopressin receptor ligand" NARROW [] +is_a: GO:0031893 ! vasopressin receptor binding + +[Term] +id: GO:0031896 +name: V2 vasopressin receptor binding +namespace: molecular_function +def: "Interacting selectively with a V2 vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "V2 vasopressin receptor ligand" NARROW [] +is_a: GO:0031893 ! vasopressin receptor binding + +[Term] +id: GO:0031897 +name: Tic complex +namespace: cellular_component +def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016] +synonym: "chloroplast inner membrane translocase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009706 ! chloroplast inner membrane + +[Term] +id: GO:0031898 +name: chromoplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009509 ! chromoplast + +[Term] +id: GO:0031899 +name: chromoplast inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0046862 ! chromoplast membrane + +[Term] +id: GO:0031900 +name: chromoplast outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz] +is_a: GO:0009527 ! plastid outer membrane +is_a: GO:0046862 ! chromoplast membrane + +[Term] +id: GO:0031901 +name: early endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an early endosome." [GOC:pz] +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0005769 ! early endosome + +[Term] +id: GO:0031902 +name: late endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a late endosome." [GOC:pz] +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0005770 ! late endosome + +[Term] +id: GO:0031903 +name: microbody membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a microbody." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0042579 ! microbody + +[Term] +id: GO:0031904 +name: endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an endosome." [GOC:mah] +is_a: GO:0044440 ! endosomal part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0031905 +name: early endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an early endosome." [GOC:mah] +is_a: GO:0031904 ! endosome lumen +relationship: part_of GO:0005769 ! early endosome + +[Term] +id: GO:0031906 +name: late endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a late endosome." [GOC:mah] +is_a: GO:0031904 ! endosome lumen +relationship: part_of GO:0005770 ! late endosome + +[Term] +id: GO:0031907 +name: microbody lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a microbody." [GOC:mah] +is_a: GO:0044438 ! microbody part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0031908 +name: glyoxysomal lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah] +is_a: GO:0031907 ! microbody lumen +relationship: part_of GO:0009514 ! glyoxysome + +[Term] +id: GO:0031909 +name: peroxisomal lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a peroxisome." [GOC:mah] +is_a: GO:0031907 ! microbody lumen +is_a: GO:0044439 ! peroxisomal part + +[Term] +id: GO:0031910 +name: cytostome +namespace: cellular_component +def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0031911 +name: cytoproct +namespace: cellular_component +def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0031912 +name: oral apparatus +namespace: cellular_component +def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189] +comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0031913 +name: contractile vacuole pore +namespace: cellular_component +def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044437 ! vacuolar part +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005884 ! actin filament +relationship: part_of GO:0031164 ! contractile vacuolar membrane + +[Term] +id: GO:0031914 +name: negative regulation of synaptic plasticity +namespace: biological_process +def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] +synonym: "down regulation of synaptic plasticity" EXACT [] +synonym: "down-regulation of synaptic plasticity" EXACT [] +synonym: "downregulation of synaptic plasticity" EXACT [] +synonym: "inhibition of synaptic plasticity" NARROW [] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0031915 +name: positive regulation of synaptic plasticity +namespace: biological_process +def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] +synonym: "activation of synaptic plasticity" NARROW [] +synonym: "stimulation of synaptic plasticity" NARROW [] +synonym: "up regulation of synaptic plasticity" EXACT [] +synonym: "up-regulation of synaptic plasticity" EXACT [] +synonym: "upregulation of synaptic plasticity" EXACT [] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0031916 +name: regulation of synaptic metaplasticity +namespace: biological_process +def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0031917 +name: negative regulation of synaptic metaplasticity +namespace: biological_process +def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] +synonym: "down regulation of synaptic metaplasticity" EXACT [] +synonym: "down-regulation of synaptic metaplasticity" EXACT [] +synonym: "downregulation of synaptic metaplasticity" EXACT [] +synonym: "inhibition of synaptic metaplasticity" NARROW [] +is_a: GO:0031914 ! negative regulation of synaptic plasticity +is_a: GO:0031916 ! regulation of synaptic metaplasticity + +[Term] +id: GO:0031918 +name: positive regulation of synaptic metaplasticity +namespace: biological_process +def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] +synonym: "activation of synaptic metaplasticity" NARROW [] +synonym: "stimulation of synaptic metaplasticity" NARROW [] +synonym: "up regulation of synaptic metaplasticity" EXACT [] +synonym: "up-regulation of synaptic metaplasticity" EXACT [] +synonym: "upregulation of synaptic metaplasticity" EXACT [] +is_a: GO:0031915 ! positive regulation of synaptic plasticity +is_a: GO:0031916 ! regulation of synaptic metaplasticity + +[Term] +id: GO:0031919 +name: vitamin B6 transport +namespace: biological_process +def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells." [GOC:mah] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0031920 +name: pyridoxal transport +namespace: biological_process +def: "The directed movement of pyridoxal into, out of, within or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031921 +name: pyridoxal phosphate transport +namespace: biological_process +def: "The directed movement of pyridoxal phosphate into, out of, within or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031922 +name: pyridoxamine transport +namespace: biological_process +def: "The directed movement of pyridoxamine into, out of, within or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031923 +name: pyridoxine transport +namespace: biological_process +def: "The directed movement of pyridoxine into, out of, within or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031924 +name: vitamin B6 transporter activity +namespace: molecular_function +def: "Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells." [GOC:mah] +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0031925 +name: pyridoxal transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of pyridoxal across a membrane into, out of, within or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +synonym: "pyridoxal transporter activity" BROAD [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0031924 ! vitamin B6 transporter activity + +[Term] +id: GO:0031926 +name: pyridoxal phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of pyridoxal phosphate into, out of, within or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0031924 ! vitamin B6 transporter activity + +[Term] +id: GO:0031927 +name: pyridoxamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of pyridoxamine into, out of, within or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0031924 ! vitamin B6 transporter activity + +[Term] +id: GO:0031928 +name: pyridoxine transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of pyridoxine across a membrane into, out of, within or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +synonym: "pyridoxine transporter activity" BROAD [] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity +is_a: GO:0031924 ! vitamin B6 transporter activity + +[Term] +id: GO:0031929 +name: TOR signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] +comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. +synonym: "target of rapamycin signaling pathway" EXACT [] +synonym: "target of rapamycin signalling pathway" EXACT [] +synonym: "TOR signalling pathway" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0031930 +name: mitochondrial signaling pathway +namespace: biological_process +def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799] +synonym: "mitochondrial signalling pathway" EXACT [] +synonym: "retrograde response" EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade + +[Term] +id: GO:0031931 +name: TORC1 complex +namespace: cellular_component +def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy." [GOC:jh, PMID:15780592] +synonym: "nutrient sensitive complex" EXACT [] +synonym: "TOR complex 1" EXACT [] +synonym: "TORC 1 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031932 +name: TORC2 complex +namespace: cellular_component +def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization." [GOC:jh, PMID:15780592] +synonym: "TORC 2 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0031933 +name: telomeric heterochromatin +namespace: cellular_component +def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0031934 +name: mating-type region heterochromatin +namespace: cellular_component +def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0031935 +name: regulation of chromatin silencing +namespace: biological_process +def: "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] +synonym: "regulation of heterochromatic silencing" RELATED [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0031445 ! regulation of heterochromatin formation +relationship: regulates GO:0006342 ! chromatin silencing + +[Term] +id: GO:0031936 +name: negative regulation of chromatin silencing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] +synonym: "down regulation of chromatin silencing" EXACT [] +synonym: "down-regulation of chromatin silencing" EXACT [] +synonym: "downregulation of chromatin silencing" EXACT [] +synonym: "inhibition of chromatin silencing" NARROW [] +synonym: "negative regulation of heterochromatic silencing" EXACT [] +is_a: GO:0031452 ! negative regulation of heterochromatin formation +is_a: GO:0031935 ! regulation of chromatin silencing +is_a: GO:0045815 ! positive regulation of gene expression, epigenetic +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +relationship: negatively_regulates GO:0006342 ! chromatin silencing + +[Term] +id: GO:0031937 +name: positive regulation of chromatin silencing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah] +synonym: "activation of chromatin silencing" NARROW [] +synonym: "positive regulation of heterochromatic silencing" EXACT [] +synonym: "stimulation of chromatin silencing" NARROW [] +synonym: "up regulation of chromatin silencing" EXACT [] +synonym: "up-regulation of chromatin silencing" EXACT [] +synonym: "upregulation of chromatin silencing" EXACT [] +is_a: GO:0031453 ! positive regulation of heterochromatin formation +is_a: GO:0031935 ! regulation of chromatin silencing +relationship: positively_regulates GO:0006342 ! chromatin silencing + +[Term] +id: GO:0031938 +name: regulation of chromatin silencing at telomere +namespace: biological_process +def: "Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah] +synonym: "regulation of heterochromatic silencing at telomere" EXACT [] +is_a: GO:0031935 ! regulation of chromatin silencing +relationship: regulates GO:0006348 ! chromatin silencing at telomere + +[Term] +id: GO:0031939 +name: negative regulation of chromatin silencing at telomere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] +synonym: "down regulation of chromatin silencing at telomere" EXACT [] +synonym: "down-regulation of chromatin silencing at telomere" EXACT [] +synonym: "downregulation of chromatin silencing at telomere" EXACT [] +synonym: "inhibition of chromatin silencing at telomere" NARROW [] +synonym: "negative regulation of heterochromatic silencing at telomere" EXACT [] +is_a: GO:0031936 ! negative regulation of chromatin silencing +is_a: GO:0031938 ! regulation of chromatin silencing at telomere +relationship: negatively_regulates GO:0006348 ! chromatin silencing at telomere + +[Term] +id: GO:0031940 +name: positive regulation of chromatin silencing at telomere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] +synonym: "activation of chromatin silencing at telomere" NARROW [] +synonym: "positive regulation of heterochromatic silencing at telomere" EXACT [] +synonym: "stimulation of chromatin silencing at telomere" NARROW [] +synonym: "up regulation of chromatin silencing at telomere" EXACT [] +synonym: "up-regulation of chromatin silencing at telomere" EXACT [] +synonym: "upregulation of chromatin silencing at telomere" EXACT [] +is_a: GO:0031937 ! positive regulation of chromatin silencing +is_a: GO:0031938 ! regulation of chromatin silencing at telomere +relationship: positively_regulates GO:0006348 ! chromatin silencing at telomere + +[Term] +id: GO:0031941 +name: filamentous actin +namespace: cellular_component +def: "A two-stranded helical polymer of the protein actin." [GOC:mah] +comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. +synonym: "F-actin" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0005884 ! actin filament + +[Term] +id: GO:0031942 +name: i-AAA complex +namespace: cellular_component +def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0031943 +name: regulation of glucocorticoid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] +synonym: "regulation of glucocorticoid metabolism" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031944 +name: negative regulation of glucocorticoid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] +synonym: "down regulation of glucocorticoid metabolic process" EXACT [] +synonym: "down-regulation of glucocorticoid metabolic process" EXACT [] +synonym: "downregulation of glucocorticoid metabolic process" EXACT [] +synonym: "inhibition of glucocorticoid metabolic process" NARROW [] +synonym: "negative regulation of glucocorticoid metabolism" EXACT [] +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031945 +name: positive regulation of glucocorticoid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] +synonym: "activation of glucocorticoid metabolic process" NARROW [] +synonym: "positive regulation of glucocorticoid metabolism" EXACT [] +synonym: "stimulation of glucocorticoid metabolic process" NARROW [] +synonym: "up regulation of glucocorticoid metabolic process" EXACT [] +synonym: "up-regulation of glucocorticoid metabolic process" EXACT [] +synonym: "upregulation of glucocorticoid metabolic process" EXACT [] +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031946 +name: regulation of glucocorticoid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031947 +name: negative regulation of glucocorticoid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] +synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] +is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031948 +name: positive regulation of glucocorticoid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] +synonym: "activation of glucocorticoid biosynthetic process" NARROW [] +synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] +synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] +is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031949 +name: regulation of glucocorticoid catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0006713 ! glucocorticoid catabolic process + +[Term] +id: GO:0031950 +name: negative regulation of glucocorticoid catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] +synonym: "down regulation of glucocorticoid catabolic process" EXACT [] +synonym: "down-regulation of glucocorticoid catabolic process" EXACT [] +synonym: "downregulation of glucocorticoid catabolic process" EXACT [] +synonym: "inhibition of glucocorticoid catabolic process" NARROW [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process +is_a: GO:0031949 ! regulation of glucocorticoid catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process + +[Term] +id: GO:0031951 +name: positive regulation of glucocorticoid catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] +synonym: "activation of glucocorticoid catabolic process" NARROW [] +synonym: "stimulation of glucocorticoid catabolic process" NARROW [] +synonym: "up regulation of glucocorticoid catabolic process" EXACT [] +synonym: "up-regulation of glucocorticoid catabolic process" EXACT [] +synonym: "upregulation of glucocorticoid catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process +is_a: GO:0031949 ! regulation of glucocorticoid catabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process + +[Term] +id: GO:0031952 +name: regulation of protein amino acid autophosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +relationship: regulates GO:0046777 ! protein amino acid autophosphorylation + +[Term] +id: GO:0031953 +name: negative regulation of protein amino acid autophosphorylation +namespace: biological_process +def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] +synonym: "down regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "downregulation of protein amino acid autophosphorylation" EXACT [] +synonym: "inhibition of protein amino acid autophosphorylation" NARROW [] +is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation +is_a: GO:0031952 ! regulation of protein amino acid autophosphorylation +relationship: negatively_regulates GO:0046777 ! protein amino acid autophosphorylation + +[Term] +id: GO:0031954 +name: positive regulation of protein amino acid autophosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] +synonym: "activation of protein amino acid autophosphorylation" NARROW [] +synonym: "stimulation of protein amino acid autophosphorylation" NARROW [] +synonym: "up regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "upregulation of protein amino acid autophosphorylation" EXACT [] +is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation +is_a: GO:0031952 ! regulation of protein amino acid autophosphorylation +relationship: positively_regulates GO:0046777 ! protein amino acid autophosphorylation + +[Term] +id: GO:0031955 +name: short-chain-fatty-acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons." [EC:6.2.1.3, GOC:mah] +synonym: "short-chain fatty acid activation" RELATED [] +synonym: "short-chain fatty acid-CoA ligase activity" EXACT [] +is_a: GO:0015645 ! fatty-acid ligase activity + +[Term] +id: GO:0031956 +name: medium-chain-fatty-acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12." [EC:6.2.1.3, GOC:mah] +synonym: "medium-chain fatty acid activation" RELATED [] +synonym: "medium-chain fatty acid-CoA ligase activity" EXACT [] +is_a: GO:0015645 ! fatty-acid ligase activity + +[Term] +id: GO:0031957 +name: very-long-chain-fatty-acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18." [EC:6.2.1.3, GOC:mah] +synonym: "very-long-chain fatty acid activation" RELATED [] +synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT [] +is_a: GO:0015645 ! fatty-acid ligase activity + +[Term] +id: GO:0031958 +name: corticosteroid receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] +synonym: "corticosteroid receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0031959 +name: mineralocorticoid receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] +synonym: "mineralocorticoid receptor signalling pathway" EXACT [] +is_a: GO:0031958 ! corticosteroid receptor signaling pathway + +[Term] +id: GO:0031960 +name: response to corticosteroid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] +is_a: GO:0048545 ! response to steroid hormone stimulus + +[Term] +id: GO:0031961 +name: cortisol receptor binding +namespace: molecular_function +def: "Interacting selectively with a cortisol receptor." [GOC:mah, PMID:12511169] +is_a: GO:0035259 ! glucocorticoid receptor binding + +[Term] +id: GO:0031962 +name: mineralocorticoid receptor binding +namespace: molecular_function +def: "Interacting selectively with a mineralocorticoid receptor." [GOC:mah, PMID:12511169] +is_a: GO:0035258 ! steroid hormone receptor binding + +[Term] +id: GO:0031963 +name: cortisol receptor activity +namespace: molecular_function +def: "Combining with cortisol to initiate a change in cell activity." [GOC:mah, PMID:12511169] +is_a: GO:0004883 ! glucocorticoid receptor activity + +[Term] +id: GO:0031964 +name: beta-alanyl-histamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the conversion of beta-alanyl-histamine to histamine." [GOC:rc, PMID:16299587] +synonym: "carcinine hydrolase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0031965 +name: nuclear membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0031966 +name: mitochondrial membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005740 ! mitochondrial envelope + +[Term] +id: GO:0031967 +name: organelle envelope +namespace: cellular_component +def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] +subset: gosubset_prok +is_a: GO:0031975 ! envelope +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0043227 ! membrane-bounded organelle + +[Term] +id: GO:0031968 +name: organelle outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of an organelle envelope." [GOC:mah] +is_a: GO:0019867 ! outer membrane +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0031967 ! organelle envelope + +[Term] +id: GO:0031969 +name: chloroplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] +is_a: GO:0042170 ! plastid membrane +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009941 ! chloroplast envelope + +[Term] +id: GO:0031970 +name: organelle envelope lumen +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] +synonym: "organelle intermembrane space" EXACT [] +is_a: GO:0031974 ! membrane-enclosed lumen +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0031967 ! organelle envelope + +[Term] +id: GO:0031972 +name: chloroplast intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah] +synonym: "chloroplast envelope lumen" EXACT [] +is_a: GO:0009529 ! plastid intermembrane space +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009941 ! chloroplast envelope + +[Term] +id: GO:0031973 +name: chromoplast intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah] +synonym: "chromoplast envelope lumen" EXACT [] +is_a: GO:0009529 ! plastid intermembrane space +relationship: part_of GO:0031898 ! chromoplast envelope + +[Term] +id: GO:0031974 +name: membrane-enclosed lumen +namespace: cellular_component +def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0031975 +name: envelope +namespace: cellular_component +def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer, also includes the space between layers." [GOC:mah, GOC:pz] +subset: gosubset_prok +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0031976 +name: plastid thylakoid +namespace: cellular_component +def: "Any thylakoid within a plastid." [GOC:pz] +is_a: GO:0009579 ! thylakoid +is_a: GO:0031984 ! organelle subcompartment +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0031977 +name: thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz] +is_a: GO:0044436 ! thylakoid part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0031978 +name: plastid thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah] +is_a: GO:0031977 ! thylakoid lumen +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0031976 ! plastid thylakoid + +[Term] +id: GO:0031979 +name: plasma membrane-derived thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] +synonym: "plasma membrane thylakoid lumen" EXACT [] +synonym: "thylakoid lumen (sensu Cyanobacteria)" EXACT [] +is_a: GO:0031977 ! thylakoid lumen +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid + +[Term] +id: GO:0031980 +name: mitochondrial lumen +namespace: cellular_component +def: "The volume enclosed by the mitochondrial inner membrane." [GOC:mah, GOC:pz] +comment: Consider also annotating to the cellular component term 'mitochondrial matrix ; GO:0005759'. +is_a: GO:0044429 ! mitochondrial part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0031981 +name: nuclear lumen +namespace: cellular_component +def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] +is_a: GO:0044428 ! nuclear part +is_a: GO:0070013 ! intracellular organelle lumen + +[Term] +id: GO:0031982 +name: vesicle +namespace: cellular_component +def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043226 ! organelle + +[Term] +id: GO:0031983 +name: vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah] +is_a: GO:0043233 ! organelle lumen +relationship: part_of GO:0031988 ! membrane-bounded vesicle + +[Term] +id: GO:0031984 +name: organelle subcompartment +namespace: cellular_component +def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] +comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. +synonym: "suborganelle compartment" EXACT [] +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0043227 ! membrane-bounded organelle + +[Term] +id: GO:0031985 +name: Golgi cisterna +namespace: cellular_component +def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] +is_a: GO:0031984 ! organelle subcompartment +is_a: GO:0044431 ! Golgi apparatus part +relationship: part_of GO:0005795 ! Golgi stack + +[Term] +id: GO:0031986 +name: proteinoplast +namespace: cellular_component +def: "A leucoplast in which protein is stored." [GOC:pz] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0031987 +name: locomotion during locomotory behavior +namespace: biological_process +def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] +synonym: "locomotion during locomotory behaviour" EXACT [] +is_a: GO:0040011 ! locomotion +relationship: part_of GO:0007626 ! locomotory behavior + +[Term] +id: GO:0031988 +name: membrane-bounded vesicle +namespace: cellular_component +def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah] +subset: gosubset_prok +synonym: "membrane-enclosed vesicle" EXACT [] +is_a: GO:0031982 ! vesicle + +[Term] +id: GO:0031989 +name: bombesin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "bombesin receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0031990 +name: mRNA export from nucleus during heat stress +namespace: biological_process +def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw] +synonym: "mRNA export from cell nucleus during heat stress" EXACT [] +is_a: GO:0006406 ! mRNA export from nucleus +is_a: GO:0034605 ! cellular response to heat + +[Term] +id: GO:0031991 +name: regulation of contractile ring contraction involved in cytokinesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0032954 ! regulation of cytokinetic process +relationship: regulates GO:0000916 ! contractile ring contraction involved in cytokinesis + +[Term] +id: GO:0031992 +name: energy transducer activity +namespace: molecular_function +def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators] +subset: goslim_pir +synonym: "light harvesting activity" RELATED [] +synonym: "photon capture" RELATED [] +is_a: GO:0060089 ! molecular transducer activity + +[Term] +id: GO:0031993 +name: light transducer activity +namespace: molecular_function +def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg] +is_a: GO:0031992 ! energy transducer activity + +[Term] +id: GO:0031994 +name: insulin-like growth factor I binding +namespace: molecular_function +def: "Interacting selectively with insulin-like growth factor I." [GOC:mah] +synonym: "IGF-I binding" EXACT [] +is_a: GO:0005520 ! insulin-like growth factor binding + +[Term] +id: GO:0031995 +name: insulin-like growth factor II binding +namespace: molecular_function +def: "Interacting selectively with insulin-like growth factor II." [GOC:mah] +synonym: "IGF-II binding" EXACT [] +is_a: GO:0005520 ! insulin-like growth factor binding + +[Term] +id: GO:0031996 +name: thioesterase binding +namespace: molecular_function +def: "Interacting selectively with any thioesterase enzyme." [GOC:dl] +synonym: "thiolesterase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0031997 +name: N-terminal myristoylation domain binding +namespace: molecular_function +def: "Interacting selectively with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291] +is_a: GO:0047485 ! protein N-terminus binding + +[Term] +id: GO:0031998 +name: regulation of fatty acid beta-oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0046320 ! regulation of fatty acid oxidation +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0031999 +name: negative regulation of fatty acid beta-oxidation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] +synonym: "down regulation of fatty acid beta-oxidation" EXACT [] +synonym: "down-regulation of fatty acid beta-oxidation" EXACT [] +synonym: "downregulation of fatty acid beta-oxidation" EXACT [] +synonym: "inhibition of fatty acid beta-oxidation" NARROW [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0031998 ! regulation of fatty acid beta-oxidation +is_a: GO:0046322 ! negative regulation of fatty acid oxidation +is_a: GO:0050995 ! negative regulation of lipid catabolic process +relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0032000 +name: positive regulation of fatty acid beta-oxidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] +synonym: "activation of fatty acid beta-oxidation" NARROW [] +synonym: "stimulation of fatty acid beta-oxidation" NARROW [] +synonym: "up regulation of fatty acid beta-oxidation" EXACT [] +synonym: "up-regulation of fatty acid beta-oxidation" EXACT [] +synonym: "upregulation of fatty acid beta-oxidation" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0031998 ! regulation of fatty acid beta-oxidation +is_a: GO:0046321 ! positive regulation of fatty acid oxidation +is_a: GO:0050996 ! positive regulation of lipid catabolic process +relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0032001 +name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a 1,4-alpha-D-glucan." [EC:2.4.1.24] +synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "D-glucosyltransferase" BROAD [] +synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24] +synonym: "T-enzyme" NARROW [] +xref: EC:2.4.1.24 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0032002 +name: interleukin-28 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta." [GOC:rh2] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0032003 +name: interleukin-28 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-28 receptor." [GOC:rh2] +synonym: "IL-28" NARROW [] +synonym: "interleukin-28 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0032005 +name: signal transduction during conjugation with cellular fusion +namespace: biological_process +def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah] +is_a: GO:0007165 ! signal transduction +is_a: GO:0031137 ! regulation of conjugation with cellular fusion + +[Term] +id: GO:0032006 +name: regulation of TOR signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the TOR signaling pathway." [GOC:mah] +synonym: "regulation of target of rapamycin signaling pathway" EXACT [] +synonym: "regulation of target of rapamycin signalling pathway" EXACT [] +synonym: "regulation of TOR signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0031929 ! TOR signaling pathway + +[Term] +id: GO:0032007 +name: negative regulation of TOR signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the TOR signaling pathway." [GOC:mah] +synonym: "down regulation of TOR signaling pathway" EXACT [] +synonym: "down-regulation of TOR signaling pathway" EXACT [] +synonym: "downregulation of TOR signaling pathway" EXACT [] +synonym: "inhibition of TOR signaling pathway" NARROW [] +synonym: "negative regulation of target of rapamycin signaling pathway" EXACT [] +synonym: "negative regulation of target of rapamycin signalling pathway" EXACT [] +synonym: "negative regulation of TOR signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0032006 ! regulation of TOR signaling pathway +relationship: negatively_regulates GO:0031929 ! TOR signaling pathway + +[Term] +id: GO:0032008 +name: positive regulation of TOR signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the TOR signaling pathway." [GOC:mah] +synonym: "activation of TOR signaling pathway" NARROW [] +synonym: "positive regulation of target of rapamycin signaling pathway" EXACT [] +synonym: "positive regulation of target of rapamycin signalling pathway" EXACT [] +synonym: "positive regulation of TOR signalling pathway" EXACT [] +synonym: "stimulation of TOR signaling pathway" NARROW [] +synonym: "up regulation of TOR signaling pathway" EXACT [] +synonym: "up-regulation of TOR signaling pathway" EXACT [] +synonym: "upregulation of TOR signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0032006 ! regulation of TOR signaling pathway +relationship: positively_regulates GO:0031929 ! TOR signaling pathway + +[Term] +id: GO:0032009 +name: early phagosome +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753] +synonym: "early phagocytic vesicle" EXACT [] +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0032010 +name: phagolysosome +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753] +synonym: "late phagocytic vesicle" RELATED [] +synonym: "late phagosome" RELATED [] +is_a: GO:0005767 ! secondary lysosome +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0032011 +name: ARF protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032012 +name: regulation of ARF protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032011 ! ARF protein signal transduction + +[Term] +id: GO:0032013 +name: negative regulation of ARF protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] +synonym: "down regulation of ARF protein signal transduction" EXACT [] +synonym: "down-regulation of ARF protein signal transduction" EXACT [] +synonym: "downregulation of ARF protein signal transduction" EXACT [] +synonym: "inhibition of ARF protein signal transduction" NARROW [] +is_a: GO:0032012 ! regulation of ARF protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction + +[Term] +id: GO:0032014 +name: positive regulation of ARF protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] +synonym: "activation of ARF protein signal transduction" NARROW [] +synonym: "stimulation of ARF protein signal transduction" NARROW [] +synonym: "up regulation of ARF protein signal transduction" EXACT [] +synonym: "up-regulation of ARF protein signal transduction" EXACT [] +synonym: "upregulation of ARF protein signal transduction" EXACT [] +is_a: GO:0032012 ! regulation of ARF protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0032011 ! ARF protein signal transduction + +[Term] +id: GO:0032015 +name: regulation of Ran protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0032016 +name: negative regulation of Ran protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] +synonym: "down regulation of Ran protein signal transduction" EXACT [] +synonym: "down-regulation of Ran protein signal transduction" EXACT [] +synonym: "downregulation of Ran protein signal transduction" EXACT [] +synonym: "inhibition of Ran protein signal transduction" NARROW [] +is_a: GO:0032015 ! regulation of Ran protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0032017 +name: positive regulation of Ran protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] +synonym: "activation of Ran protein signal transduction" NARROW [] +synonym: "stimulation of Ran protein signal transduction" NARROW [] +synonym: "up regulation of Ran protein signal transduction" EXACT [] +synonym: "up-regulation of Ran protein signal transduction" EXACT [] +synonym: "upregulation of Ran protein signal transduction" EXACT [] +is_a: GO:0032015 ! regulation of Ran protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0032018 +name: 2-methylbutanal reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903] +synonym: "2-methylbutyraldehyde reductase activity" EXACT [] +is_a: GO:0004032 ! aldehyde reductase activity + +[Term] +id: GO:0032019 +name: mitochondrial cloud +namespace: cellular_component +def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166] +synonym: "Balbiani body" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0032020 +name: ISG15-protein conjugation +namespace: biological_process +def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0032021 +name: NELF complex +namespace: cellular_component +def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] +synonym: "negative elongation factor complex" EXACT [] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0032022 +name: pellicle formation +namespace: biological_process +def: "A process whereby microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml] +is_a: GO:0042710 ! biofilm formation + +[Term] +id: GO:0032023 +name: trypsinogen activation +namespace: biological_process +def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah] +is_a: GO:0031638 ! zymogen activation + +[Term] +id: GO:0032024 +name: positive regulation of insulin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] +synonym: "activation of insulin secretion" NARROW [] +synonym: "stimulation of insulin secretion" NARROW [] +synonym: "up regulation of insulin secretion" EXACT [] +synonym: "up-regulation of insulin secretion" EXACT [] +synonym: "upregulation of insulin secretion" EXACT [] +is_a: GO:0002793 ! positive regulation of peptide secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0050796 ! regulation of insulin secretion +relationship: positively_regulates GO:0030073 ! insulin secretion + +[Term] +id: GO:0032025 +name: response to cobalt ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0032026 +name: response to magnesium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0032027 +name: myosin light chain binding +namespace: molecular_function +def: "Interacting selectively with a light chain of a myosin complex." [GOC:mah] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0032028 +name: myosin head/neck binding +namespace: molecular_function +def: "Interacting selectively with the head/neck region of a myosin heavy chain." [GOC:mah] +is_a: GO:0032036 ! myosin heavy chain binding + +[Term] +id: GO:0032029 +name: myosin tail binding +namespace: molecular_function +def: "Interacting selectively with the tail region of a myosin heavy chain." [GOC:mah] +is_a: GO:0032036 ! myosin heavy chain binding + +[Term] +id: GO:0032030 +name: myosin I light chain binding +namespace: molecular_function +def: "Interacting selectively with a light chain of a myosin I complex." [GOC:mah] +is_a: GO:0017024 ! myosin I binding +is_a: GO:0032027 ! myosin light chain binding + +[Term] +id: GO:0032031 +name: myosin I head/neck binding +namespace: molecular_function +def: "Interacting selectively with the head/neck region of a myosin I heavy chain." [GOC:mah] +is_a: GO:0032028 ! myosin head/neck binding +is_a: GO:0032037 ! myosin I heavy chain binding + +[Term] +id: GO:0032032 +name: myosin I tail binding +namespace: molecular_function +def: "Interacting selectively with the tail region of a myosin I heavy chain." [GOC:mah] +is_a: GO:0032029 ! myosin tail binding +is_a: GO:0032037 ! myosin I heavy chain binding + +[Term] +id: GO:0032033 +name: myosin II light chain binding +namespace: molecular_function +def: "Interacting selectively with a light chain of a myosin II complex." [GOC:mah] +is_a: GO:0032027 ! myosin light chain binding +is_a: GO:0045159 ! myosin II binding + +[Term] +id: GO:0032034 +name: myosin II head/neck binding +namespace: molecular_function +def: "Interacting selectively with the head/neck region of a myosin II heavy chain." [GOC:mah] +is_a: GO:0032028 ! myosin head/neck binding +is_a: GO:0032038 ! myosin II heavy chain binding + +[Term] +id: GO:0032035 +name: myosin II tail binding +namespace: molecular_function +def: "Interacting selectively with the tail region of a myosin II heavy chain." [GOC:mah] +is_a: GO:0032029 ! myosin tail binding +is_a: GO:0032038 ! myosin II heavy chain binding + +[Term] +id: GO:0032036 +name: myosin heavy chain binding +namespace: molecular_function +def: "Interacting selectively with a heavy chain of a myosin complex." [GOC:mah] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0032037 +name: myosin I heavy chain binding +namespace: molecular_function +def: "Interacting selectively with a heavy chain of a myosin I complex." [GOC:mah] +is_a: GO:0017024 ! myosin I binding +is_a: GO:0032036 ! myosin heavy chain binding + +[Term] +id: GO:0032038 +name: myosin II heavy chain binding +namespace: molecular_function +def: "Interacting selectively with a heavy chain of a myosin II complex." [GOC:mah] +is_a: GO:0032036 ! myosin heavy chain binding +is_a: GO:0045159 ! myosin II binding + +[Term] +id: GO:0032039 +name: integrator complex +namespace: cellular_component +def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0032040 +name: small-subunit processome +namespace: cellular_component +def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] +synonym: "small subunit processome" EXACT [] +synonym: "SSU processome" EXACT [] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0032041 +name: NAD-dependent histone deacetylase activity (H3-K14 specific) +namespace: molecular_function +def: "Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 14 of the histone H3 protein." [GOC:mah] +is_a: GO:0017136 ! NAD-dependent histone deacetylase activity +is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific) + +[Term] +id: GO:0032042 +name: mitochondrial DNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] +synonym: "mitochondrial DNA metabolism" EXACT [] +synonym: "mtDNA metabolic process" EXACT [] +synonym: "mtDNA metabolism" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0000002 ! mitochondrial genome maintenance + +[Term] +id: GO:0032043 +name: mitochondrial DNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] +synonym: "mitochondrial DNA breakdown" EXACT [] +synonym: "mitochondrial DNA catabolism" EXACT [] +synonym: "mitochondrial DNA degradation" EXACT [] +synonym: "mtDNA breakdown" EXACT [] +synonym: "mtDNA catabolic process" EXACT [] +synonym: "mtDNA catabolism" EXACT [] +synonym: "mtDNA degradation" EXACT [] +is_a: GO:0006308 ! DNA catabolic process +is_a: GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:0032044 +name: DSIF complex +namespace: cellular_component +def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788] +synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT [] +synonym: "DRB sensitivity inducing factor complex" EXACT [] +synonym: "Spt4-Spt5 complex" EXACT [] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0032045 +name: guanyl-nucleotide exchange factor complex +namespace: cellular_component +def: "A protein complex that stimulates the exchange of guanyl nucleotides by a GTPase." [GOC:mah] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0032046 +name: micropexophagy-specific membrane apparatus +namespace: cellular_component +def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611] +synonym: "micropexophagic apparatus" EXACT [] +synonym: "MIPA" EXACT [] +is_a: GO:0031984 ! organelle subcompartment +is_a: GO:0044437 ! vacuolar part + +[Term] +id: GO:0032047 +name: mitosome +namespace: cellular_component +def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria." [PMID:10361303, PMID:14614504] +synonym: "crypton" EXACT [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0032048 +name: cardiolipin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [ChEBI:28494, GOC:mah] +synonym: "cardiolipin metabolism" EXACT [] +synonym: "diphosphatidylglycerol metabolic process" RELATED [] +synonym: "diphosphatidylglycerol metabolism" RELATED [] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process + +[Term] +id: GO:0032049 +name: cardiolipin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [ChEBI:28494, GOC:mah] +synonym: "diphosphatidylglycerol biosynthesis" RELATED [] +synonym: "diphosphatidylglycerol biosynthetic process" RELATED [] +xref: MetaCyc:PWY-5269 +is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process +is_a: GO:0032048 ! cardiolipin metabolic process + +[Term] +id: GO:0032050 +name: clathrin heavy chain binding +namespace: molecular_function +def: "Interacting selectively with a clathrin heavy chain." [GOC:mah] +is_a: GO:0030276 ! clathrin binding + +[Term] +id: GO:0032051 +name: clathrin light chain binding +namespace: molecular_function +def: "Interacting selectively with a clathrin light chain." [GOC:mah] +is_a: GO:0030276 ! clathrin binding + +[Term] +id: GO:0032052 +name: bile acid binding +namespace: molecular_function +def: "Interacting selectively with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph] +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0032053 +name: microtubule basal body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a microtubule basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum." [GOC:dph, GOC:jl, GOC:mah, PMID:9889124] +synonym: "microtubule basal body organization and biogenesis" EXACT [] +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0032054 +name: microtubule basal body duplication +namespace: biological_process +def: "Construction of a new microtubule basal body." [PMID:9889124] +is_a: GO:0032053 ! microtubule basal body organization + +[Term] +id: GO:0032055 +name: negative regulation of translation in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "down regulation of translation in response to stress" EXACT [] +synonym: "down-regulation of translation in response to stress" EXACT [] +synonym: "downregulation of translation in response to stress" EXACT [] +synonym: "inhibition of translation in response to stress" NARROW [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0043555 ! regulation of translation in response to stress + +[Term] +id: GO:0032056 +name: positive regulation of translation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "activation of translation in response to stress" NARROW [] +synonym: "stimulation of translation in response to stress" NARROW [] +synonym: "up regulation of translation in response to stress" EXACT [] +synonym: "up-regulation of translation in response to stress" EXACT [] +synonym: "upregulation of translation in response to stress" EXACT [] +is_a: GO:0043555 ! regulation of translation in response to stress +is_a: GO:0045727 ! positive regulation of translation + +[Term] +id: GO:0032057 +name: negative regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "down regulation of translation initiation in response to stress" EXACT [] +synonym: "down-regulation of translation initiation in response to stress" EXACT [] +synonym: "downregulation of translation initiation in response to stress" EXACT [] +synonym: "inhibition of translation initiation in response to stress" NARROW [] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0043558 ! regulation of translational initiation in response to stress +is_a: GO:0045947 ! negative regulation of translational initiation + +[Term] +id: GO:0032058 +name: positive regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "activation of translation initiation in response to stress" NARROW [] +synonym: "stimulation of translation initiation in response to stress" NARROW [] +synonym: "up regulation of translation initiation in response to stress" EXACT [] +synonym: "up-regulation of translation initiation in response to stress" EXACT [] +synonym: "upregulation of translation initiation in response to stress" EXACT [] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0043558 ! regulation of translational initiation in response to stress +is_a: GO:0045948 ! positive regulation of translational initiation + +[Term] +id: GO:0032059 +name: bleb +namespace: cellular_component +def: "A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291] +subset: goslim_pir +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0032060 +name: bleb formation +namespace: biological_process +def: "The assembly of a bleb, a cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291] +synonym: "cell blebbing" EXACT [] +is_a: GO:0030031 ! cell projection biogenesis + +[Term] +id: GO:0032061 +name: negative regulation of translation in response to osmotic stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "down regulation of translation in response to osmotic stress" EXACT [] +synonym: "down-regulation of translation in response to osmotic stress" EXACT [] +synonym: "downregulation of translation in response to osmotic stress" EXACT [] +synonym: "inhibition of translation in response to osmotic stress" NARROW [] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0043557 ! regulation of translation in response to osmotic stress + +[Term] +id: GO:0032062 +name: positive regulation of translation in response to osmotic stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "activation of translation in response to osmotic stress" NARROW [] +synonym: "stimulation of translation in response to osmotic stress" NARROW [] +synonym: "up regulation of translation in response to osmotic stress" EXACT [] +synonym: "up-regulation of translation in response to osmotic stress" EXACT [] +synonym: "upregulation of translation in response to osmotic stress" EXACT [] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0043557 ! regulation of translation in response to osmotic stress + +[Term] +id: GO:0032063 +name: negative regulation of translational initiation in response to osmotic stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "down regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "downregulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "inhibition of translation initiation in response to osmotic stress" NARROW [] +is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress +is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress + +[Term] +id: GO:0032064 +name: positive regulation of translational initiation in response to osmotic stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "activation of translation initiation in response to osmotic stress" NARROW [] +synonym: "stimulation of translation initiation in response to osmotic stress" NARROW [] +synonym: "up regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "upregulation of translation initiation in response to osmotic stress" EXACT [] +is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress +is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress + +[Term] +id: GO:0032065 +name: cortical protein anchoring +namespace: biological_process +def: "A process by which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] +synonym: "maintenance of protein location in cell cortex" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0032066 +name: nucleolus to nucleoplasm transport +namespace: biological_process +def: "The directed movement of substances from the nucleolus to the nucleoplasm." [GOC:mah] +is_a: GO:0051169 ! nuclear transport + +[Term] +id: GO:0032067 +name: Type IV site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995] +synonym: "Type IV restriction enzyme activity" EXACT [] +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032068 +name: Type IV site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995] +synonym: "Type IV restriction enzyme complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0032069 +name: regulation of nuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] +synonym: "nuclease regulator activity" RELATED [] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0032070 +name: regulation of deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] +synonym: "deoxyribonuclease regulator" RELATED [] +synonym: "DNase regulator" RELATED [] +is_a: GO:0032069 ! regulation of nuclease activity + +[Term] +id: GO:0032071 +name: regulation of endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] +synonym: "endodeoxyribonuclease regulator" RELATED [] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity + +[Term] +id: GO:0032072 +name: regulation of restriction endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity + +[Term] +id: GO:0032073 +name: negative regulation of restriction endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] +synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW [] +synonym: "restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "restriction enzyme inhibitor" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity + +[Term] +id: GO:0032074 +name: negative regulation of nuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] +synonym: "down regulation of nuclease activity" EXACT [] +synonym: "down-regulation of nuclease activity" EXACT [] +synonym: "downregulation of nuclease activity" EXACT [] +synonym: "inhibition of nuclease activity" NARROW [] +synonym: "nuclease inhibitor" RELATED [] +is_a: GO:0032069 ! regulation of nuclease activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0032075 +name: positive regulation of nuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] +synonym: "activation of nuclease activity" NARROW [] +synonym: "nuclease activator" RELATED [] +synonym: "stimulation of nuclease activity" NARROW [] +synonym: "up regulation of nuclease activity" EXACT [] +synonym: "up-regulation of nuclease activity" EXACT [] +synonym: "upregulation of nuclease activity" EXACT [] +is_a: GO:0032069 ! regulation of nuclease activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0032076 +name: negative regulation of deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] +synonym: "deoxyribonuclease inhibitor" RELATED [] +synonym: "DNase inhibitor" RELATED [] +synonym: "down regulation of deoxyribonuclease activity" EXACT [] +synonym: "down-regulation of deoxyribonuclease activity" EXACT [] +synonym: "downregulation of deoxyribonuclease activity" EXACT [] +synonym: "inhibition of deoxyribonuclease activity" NARROW [] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity +is_a: GO:0032074 ! negative regulation of nuclease activity + +[Term] +id: GO:0032077 +name: positive regulation of deoxyribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] +synonym: "activation of deoxyribonuclease activity" NARROW [] +synonym: "deoxyribonuclease activator" RELATED [] +synonym: "DNase activator" RELATED [] +synonym: "stimulation of deoxyribonuclease activity" NARROW [] +synonym: "up regulation of deoxyribonuclease activity" EXACT [] +synonym: "up-regulation of deoxyribonuclease activity" EXACT [] +synonym: "upregulation of deoxyribonuclease activity" EXACT [] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity +is_a: GO:0032075 ! positive regulation of nuclease activity + +[Term] +id: GO:0032078 +name: negative regulation of endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] +synonym: "down regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of endodeoxyribonuclease activity" EXACT [] +synonym: "endodeoxyribonuclease inhibitor" RELATED [] +synonym: "inhibition of endodeoxyribonuclease activity" NARROW [] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity +is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity + +[Term] +id: GO:0032079 +name: positive regulation of endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] +synonym: "activation of endodeoxyribonuclease activity" NARROW [] +synonym: "endodeoxyribonuclease activator" RELATED [] +synonym: "stimulation of endodeoxyribonuclease activity" NARROW [] +synonym: "up regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "up-regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "upregulation of endodeoxyribonuclease activity" EXACT [] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity +is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity + +[Term] +id: GO:0032080 +name: negative regulation of Type I site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of Type I restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of Type I restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of Type I restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of Type I restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "Type I restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "Type I restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032084 ! regulation of Type I site-specific deoxyribonuclease activity + +[Term] +id: GO:0032081 +name: negative regulation of Type II site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of Type II restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of Type II restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of Type II restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of Type II restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "Type II restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "Type II restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032085 ! regulation of Type II site-specific deoxyribonuclease activity + +[Term] +id: GO:0032082 +name: negative regulation of Type III site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of Type III restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of Type III restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of Type III restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of Type III restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of Type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "Type III restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "Type III restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032086 ! regulation of Type III site-specific deoxyribonuclease activity + +[Term] +id: GO:0032083 +name: negative regulation of Type IV site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of Type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of Type IV restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of Type IV restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "Type IV restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "Type IV restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032087 ! regulation of Type IV site-specific deoxyribonuclease activity + +[Term] +id: GO:0032084 +name: regulation of Type I site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] +synonym: "regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph] +synonym: "Type I restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "Type I restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032085 +name: regulation of Type II site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] +synonym: "regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph] +synonym: "Type II restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "Type II restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032086 +name: regulation of Type III site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] +synonym: "regulation of Type III restriction endoribonuclease activity" EXACT [GOC:dph] +synonym: "Type III restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "Type III restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032087 +name: regulation of Type IV site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a Type IV restriction endodeoxyribonuclease activity." [GOC:mah] +synonym: "regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph] +synonym: "Type IV restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "Type IV restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032088 +name: negative regulation of NF-kappaB transcription factor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "NF-kappaB inhibitor" RELATED [] +is_a: GO:0043433 ! negative regulation of transcription factor activity + +[Term] +id: GO:0032089 +name: NACHT domain binding +namespace: molecular_function +def: "Interacting selectively with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032090 +name: Pyrin domain binding +namespace: molecular_function +def: "Interacting selectively with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] +synonym: "DAPIN domain binding" EXACT [] +synonym: "PAAD domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032091 +name: negative regulation of protein binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein binding." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of protein binding" EXACT [] +synonym: "down-regulation of protein binding" EXACT [] +synonym: "downregulation of protein binding" EXACT [] +synonym: "inhibition of protein binding" NARROW [] +is_a: GO:0043393 ! regulation of protein binding +is_a: GO:0051100 ! negative regulation of binding + +[Term] +id: GO:0032092 +name: positive regulation of protein binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] +subset: gosubset_prok +synonym: "activation of protein binding" NARROW [] +synonym: "stimulation of protein binding" NARROW [] +synonym: "up regulation of protein binding" EXACT [] +synonym: "up-regulation of protein binding" EXACT [] +synonym: "upregulation of protein binding" EXACT [] +is_a: GO:0043393 ! regulation of protein binding +is_a: GO:0051099 ! positive regulation of binding + +[Term] +id: GO:0032093 +name: SAM domain binding +namespace: molecular_function +def: "Interacting selectively with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] +synonym: "Sterile Alpha Motif domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032094 +name: response to food +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464] +is_a: GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032095 +name: regulation of response to food +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: regulates GO:0032094 ! response to food + +[Term] +id: GO:0032096 +name: negative regulation of response to food +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add] +synonym: "down regulation of response to food" EXACT [] +synonym: "down-regulation of response to food" EXACT [] +synonym: "downregulation of response to food" EXACT [] +synonym: "inhibition of response to food" NARROW [] +is_a: GO:0032095 ! regulation of response to food +is_a: GO:0032108 ! negative regulation of response to nutrient levels +relationship: negatively_regulates GO:0032094 ! response to food + +[Term] +id: GO:0032097 +name: positive regulation of response to food +namespace: biological_process +def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add] +synonym: "activation of response to food" NARROW [] +synonym: "stimulation of response to food" NARROW [] +synonym: "up regulation of response to food" EXACT [] +synonym: "up-regulation of response to food" EXACT [] +synonym: "upregulation of response to food" EXACT [] +is_a: GO:0032095 ! regulation of response to food +is_a: GO:0032109 ! positive regulation of response to nutrient levels +relationship: positively_regulates GO:0032094 ! response to food + +[Term] +id: GO:0032098 +name: regulation of appetite +namespace: biological_process +def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add] +synonym: "regulation of hunger" RELATED [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032099 +name: negative regulation of appetite +namespace: biological_process +def: "Any process that reduces appetite." [GOC:add] +synonym: "appetite suppression" RELATED [] +synonym: "down regulation of appetite" EXACT [] +synonym: "down-regulation of appetite" EXACT [] +synonym: "downregulation of appetite" EXACT [] +synonym: "inhibition of appetite" NARROW [] +synonym: "negative regulation of hunger" RELATED [] +is_a: GO:0032096 ! negative regulation of response to food +is_a: GO:0032098 ! regulation of appetite + +[Term] +id: GO:0032100 +name: positive regulation of appetite +namespace: biological_process +def: "Any process that increases appetite." [GOC:add] +synonym: "activation of appetite" NARROW [] +synonym: "appetite stimulation" RELATED [] +synonym: "positive regulation of hunger" RELATED [] +synonym: "stimulation of appetite" NARROW [] +synonym: "up regulation of appetite" EXACT [] +synonym: "up-regulation of appetite" EXACT [] +synonym: "upregulation of appetite" EXACT [] +is_a: GO:0032097 ! positive regulation of response to food +is_a: GO:0032098 ! regulation of appetite + +[Term] +id: GO:0032101 +name: regulation of response to external stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009605 ! response to external stimulus + +[Term] +id: GO:0032102 +name: negative regulation of response to external stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] +synonym: "down regulation of response to external stimulus" EXACT [] +synonym: "down-regulation of response to external stimulus" EXACT [] +synonym: "downregulation of response to external stimulus" EXACT [] +synonym: "inhibition of response to external stimulus" NARROW [] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009605 ! response to external stimulus + +[Term] +id: GO:0032103 +name: positive regulation of response to external stimulus +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] +synonym: "activation of response to external stimulus" NARROW [] +synonym: "stimulation of response to external stimulus" NARROW [] +synonym: "up regulation of response to external stimulus" EXACT [] +synonym: "up-regulation of response to external stimulus" EXACT [] +synonym: "upregulation of response to external stimulus" EXACT [] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009605 ! response to external stimulus + +[Term] +id: GO:0032104 +name: regulation of response to extracellular stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0032105 +name: negative regulation of response to extracellular stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] +synonym: "down regulation of response to extracellular stimulus" EXACT [] +synonym: "down-regulation of response to extracellular stimulus" EXACT [] +synonym: "downregulation of response to extracellular stimulus" EXACT [] +synonym: "inhibition of response to extracellular stimulus" NARROW [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0032106 +name: positive regulation of response to extracellular stimulus +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah] +synonym: "activation of response to extracellular stimulus" NARROW [] +synonym: "stimulation of response to extracellular stimulus" NARROW [] +synonym: "up regulation of response to extracellular stimulus" EXACT [] +synonym: "up-regulation of response to extracellular stimulus" EXACT [] +synonym: "upregulation of response to extracellular stimulus" EXACT [] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: positively_regulates GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0032107 +name: regulation of response to nutrient levels +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah] +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: regulates GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032108 +name: negative regulation of response to nutrient levels +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah] +synonym: "down regulation of response to nutrient levels" EXACT [] +synonym: "down-regulation of response to nutrient levels" EXACT [] +synonym: "downregulation of response to nutrient levels" EXACT [] +synonym: "inhibition of response to nutrient levels" NARROW [] +is_a: GO:0032105 ! negative regulation of response to extracellular stimulus +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: negatively_regulates GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032109 +name: positive regulation of response to nutrient levels +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah] +synonym: "activation of response to nutrient levels" NARROW [] +synonym: "stimulation of response to nutrient levels" NARROW [] +synonym: "up regulation of response to nutrient levels" EXACT [] +synonym: "up-regulation of response to nutrient levels" EXACT [] +synonym: "upregulation of response to nutrient levels" EXACT [] +is_a: GO:0032106 ! positive regulation of response to extracellular stimulus +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: positively_regulates GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032110 +name: regulation of protein histidine kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0032111 +name: activation of protein histidine kinase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah] +synonym: "protein histidine kinase activator" RELATED [] +is_a: GO:0032110 ! regulation of protein histidine kinase activity +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:0032112 +name: negative regulation of protein histidine kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] +synonym: "down regulation of protein histidine kinase activity" EXACT [] +synonym: "down-regulation of protein histidine kinase activity" EXACT [] +synonym: "downregulation of protein histidine kinase activity" EXACT [] +synonym: "inhibition of protein histidine kinase activity" NARROW [] +synonym: "protein histidine kinase inhibitor" RELATED [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0032110 ! regulation of protein histidine kinase activity + +[Term] +id: GO:0032113 +name: regulation of carbohydrate phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0032114 +name: regulation of glucose-6-phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp] +is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity + +[Term] +id: GO:0032115 +name: sorbose reductase activity +namespace: molecular_function +def: "L-sorbose + NADPH + H+ = D-glucitol + NADP+. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.11.289, GOC:mcc] +synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289] +synonym: "Sou1p" RELATED [EC:1.1.1.289] +xref: EC:1.1.1.289 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0032116 +name: cohesin loading complex +namespace: cellular_component +def: "A complex required for the loading of cohesin onto DNA prior to the establishment of cohesion. Appears to be eukaryotically conserved." [GOC:vw, PMID:10882066] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0032117 +name: horsetail-astral microtubule array +namespace: cellular_component +def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942] +synonym: "HAA" EXACT [] +is_a: GO:0005818 ! aster + +[Term] +id: GO:0032118 +name: horsetail-astral microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah] +synonym: "horsetail-astral microtubule array organization and biogenesis" EXACT [] +synonym: "horsetail-astral microtubule organization and biogenesis" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0032119 +name: sequestering of zinc ion +namespace: biological_process +def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah] +is_a: GO:0051238 ! sequestering of metal ion +relationship: part_of GO:0006882 ! cellular zinc ion homeostasis + +[Term] +id: GO:0032120 +name: ascospore-type prospore membrane formation +namespace: biological_process +def: "The process by which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt] +synonym: "forespore membrane biosynthesis" EXACT [] +synonym: "forespore membrane formation" EXACT [] +synonym: "FSM assembly" EXACT [] +synonym: "FSM biosynthesis" EXACT [] +synonym: "FSM formation" EXACT [] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0031321 ! ascospore-type prospore formation + +[Term] +id: GO:0032121 +name: attachment of telomeres to spindle pole body +namespace: biological_process +def: "The cell cycle process whereby physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation." [PMID:16615890] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0045141 ! meiotic telomere clustering + +[Term] +id: GO:0032122 +name: oral apparatus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830] +synonym: "oral apparatus morphogenesis" RELATED [] +synonym: "oral apparatus organization and biogenesis" EXACT [] +synonym: "stomatogenesis" RELATED [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0032123 +name: deep fiber +namespace: cellular_component +def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189] +synonym: "deep fibre" EXACT [] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0031912 ! oral apparatus + +[Term] +id: GO:0032124 +name: macronucleus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] +synonym: "macronuclear organization" EXACT [] +synonym: "macronuclear organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0032125 +name: micronucleus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] +synonym: "micronuclear organization" EXACT [] +synonym: "micronuclear organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0032126 +name: eisosome +namespace: cellular_component +def: "Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p." [PMID:16496001] +is_a: GO:0043234 ! protein complex +is_a: GO:0044448 ! cell cortex part + +[Term] +id: GO:0032127 +name: dense core granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0031045 ! dense core granule + +[Term] +id: GO:0032128 +name: flocculation via extracellular polymer +namespace: biological_process +def: "Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment." [DOI:10.1007/s002530051351, GOC:mah, PMID:14538073] +subset: gosubset_prok +synonym: "flocculation via EBF" EXACT [] +synonym: "flocculation via extracellular biopolymeric flocculants" EXACT [] +is_a: GO:0000128 ! flocculation + +[Term] +id: GO:0032129 +name: histone deacetylase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [GOC:mah] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0032130 +name: medial membrane band formation +namespace: biological_process +def: "The formation of sterol rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003] +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0032131 +name: alkylated DNA binding +namespace: molecular_function +def: "Interacting selectively with alkylated residues in DNA." [GOC:mah] +is_a: GO:0003684 ! damaged DNA binding + +[Term] +id: GO:0032132 +name: O6-alkylguanine-DNA binding +namespace: molecular_function +def: "Interacting selectively with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453] +is_a: GO:0032131 ! alkylated DNA binding + +[Term] +id: GO:0032133 +name: chromosome passenger complex +namespace: cellular_component +def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain containing protein survivin, aurora kinase and INCENP." [GOC:vw, PMID:16824200] +is_a: GO:0005875 ! microtubule associated complex + +[Term] +id: GO:0032134 +name: mispaired DNA binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing pyrimidine/purine mispairs." [GOC:vk] +synonym: "mispair binding" EXACT [] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0032135 +name: DNA insertion or deletion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing insertions or deletions." [GOC:vk] +synonym: "DNA insertion binding" NARROW [] +synonym: "insertion binding" EXACT [] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0032136 +name: adenine/cytosine mispair binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing an A/C mispair." [GOC:vk] +synonym: "A/C mispair binding" EXACT [] +is_a: GO:0032134 ! mispaired DNA binding + +[Term] +id: GO:0032137 +name: guanine/thymine mispair binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a G/T mispair." [GOC:vk] +synonym: "G/T mispair binding" EXACT [] +is_a: GO:0032134 ! mispaired DNA binding + +[Term] +id: GO:0032138 +name: single base insertion or deletion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] +synonym: "single base insertion binding" NARROW [] +is_a: GO:0032135 ! DNA insertion or deletion binding + +[Term] +id: GO:0032139 +name: dinucleotide insertion or deletion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk] +synonym: "dinucleotide insertion binding" NARROW [] +is_a: GO:0032135 ! DNA insertion or deletion binding + +[Term] +id: GO:0032140 +name: single adenine insertion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032141 +name: single cytosine insertion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032142 +name: single guanine insertion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032143 +name: single thymine insertion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032144 +name: 4-aminobutyrate transaminase complex +namespace: cellular_component +def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998] +synonym: "ABAT complex" EXACT [] +synonym: "GABA transaminase complex" EXACT [] +synonym: "GABA-T complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0032145 +name: succinate-semialdehyde dehydrogenase binding +namespace: molecular_function +def: "Interacting selectively with succinate-semialdehyde dehydrogenase." [GOC:mah] +synonym: "succinic semialdehyde dehydrogenase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0032146 +name: thiosulfate transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg] +is_a: GO:0015117 ! thiosulfate transmembrane transporter activity +is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity + +[Term] +id: GO:0032147 +name: activation of protein kinase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah] +synonym: "protein kinase activation" RELATED [] +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0032148 +name: activation of protein kinase B activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg] +synonym: "protein kinase B activation" EXACT [] +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:0032149 +name: response to rhamnose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg] +synonym: "response to L-rhamnose stimulus" NARROW [] +is_a: GO:0009746 ! response to hexose stimulus + +[Term] +id: GO:0032150 +name: ubiquinone biosynthetic process from chorismate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032151 +name: mitotic septin complex +namespace: cellular_component +def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555] +is_a: GO:0031105 ! septin complex + +[Term] +id: GO:0032152 +name: meiotic septin complex +namespace: cellular_component +def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555] +is_a: GO:0031105 ! septin complex + +[Term] +id: GO:0032153 +name: cell division site +namespace: cellular_component +def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane." [GOC:krc, GOC:ns, PMID:12101122, PMID:15380095] +subset: goslim_pir +synonym: "cell division plane" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0032154 +name: cleavage furrow +namespace: cellular_component +def: "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin, is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409] +is_a: GO:0032155 ! cell division site part + +[Term] +id: GO:0032155 +name: cell division site part +namespace: cellular_component +def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] +synonym: "cell division plane part" EXACT [] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0032156 +name: septin cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0032157 +name: prospore contractile ring +namespace: cellular_component +def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] +synonym: "actomyosin ring (sensu Saccharomyces)" BROAD [] +synonym: "cytokinetic ring (sensu Saccharomyces)" BROAD [] +synonym: "meiotic contractile ring" RELATED [] +is_a: GO:0005826 ! contractile ring +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:0032158 +name: septin band +namespace: cellular_component +def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0032156 ! septin cytoskeleton + +[Term] +id: GO:0032159 +name: septin cap +namespace: cellular_component +def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] +is_a: GO:0032156 ! septin cytoskeleton +is_a: GO:0044430 ! cytoskeletal part + +[Term] +id: GO:0032160 +name: septin filament array +namespace: cellular_component +def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244] +synonym: "septin bar" RELATED [] +is_a: GO:0032156 ! septin cytoskeleton +is_a: GO:0044430 ! cytoskeletal part + +[Term] +id: GO:0032161 +name: cleavage apparatus septin structure +namespace: cellular_component +def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555] +is_a: GO:0032155 ! cell division site part +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0032156 ! septin cytoskeleton + +[Term] +id: GO:0032162 +name: mating projection septin band +namespace: cellular_component +def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0032158 ! septin band + +[Term] +id: GO:0032163 +name: hyphal septin band +namespace: cellular_component +def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0032158 ! septin band + +[Term] +id: GO:0032164 +name: hyphal septin cap +namespace: cellular_component +def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] +is_a: GO:0032159 ! septin cap + +[Term] +id: GO:0032165 +name: prospore septin filament array +namespace: cellular_component +def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244] +is_a: GO:0032160 ! septin filament array + +[Term] +id: GO:0032166 +name: chlamydospore septin filament array +namespace: cellular_component +def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244] +is_a: GO:0032160 ! septin filament array + +[Term] +id: GO:0032167 +name: septin patch +namespace: cellular_component +def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555] +comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure. +is_obsolete: true + +[Term] +id: GO:0032168 +name: hyphal septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring + +[Term] +id: GO:0032169 +name: prospore septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring +is_a: GO:0032161 ! cleavage apparatus septin structure +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:0032170 +name: pseudohyphal septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring + +[Term] +id: GO:0032171 +name: germ tube septin cap +namespace: cellular_component +def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] +is_a: GO:0032159 ! septin cap + +[Term] +id: GO:0032172 +name: germ tube septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244] +is_a: GO:0005940 ! septin ring +relationship: part_of GO:0032179 ! germ tube + +[Term] +id: GO:0032173 +name: septin collar +namespace: cellular_component +def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244] +is_a: GO:0032156 ! septin cytoskeleton +is_a: GO:0044430 ! cytoskeletal part + +[Term] +id: GO:0032174 +name: cellular bud neck septin collar +namespace: cellular_component +def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555] +is_a: GO:0000399 ! cellular bud neck septin structure +is_a: GO:0032161 ! cleavage apparatus septin structure +is_a: GO:0032173 ! septin collar + +[Term] +id: GO:0032175 +name: mating projection septin ring +namespace: cellular_component +def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring + +[Term] +id: GO:0032176 +name: split septin rings +namespace: cellular_component +def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244] +is_a: GO:0032156 ! septin cytoskeleton +is_a: GO:0044430 ! cytoskeletal part + +[Term] +id: GO:0032177 +name: cellular bud neck split septin rings +namespace: cellular_component +def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555] +is_a: GO:0000399 ! cellular bud neck septin structure +is_a: GO:0032161 ! cleavage apparatus septin structure +is_a: GO:0032176 ! split septin rings + +[Term] +id: GO:0032178 +name: medial membrane band +namespace: cellular_component +def: "A sterol rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003] +synonym: "sterol-rich membrane band" RELATED [] +is_a: GO:0032155 ! cell division site part + +[Term] +id: GO:0032179 +name: germ tube +namespace: cellular_component +def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] +subset: goslim_pir +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0032180 +name: ubiquinone biosynthetic process from tyrosine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032181 +name: dinucleotide repeat insertion binding +namespace: molecular_function +def: "Interacting selectively with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk] +is_a: GO:0032139 ! dinucleotide insertion or deletion binding + +[Term] +id: GO:0032182 +name: small conjugating protein binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032183 +name: SUMO binding +namespace: molecular_function +def: "Interacting selectively with the small ubiquitin-like protein SUMO." [GOC:mah] +synonym: "Smt3 binding" RELATED [] +synonym: "Smt3 monomer binding" NARROW [] +is_a: GO:0032182 ! small conjugating protein binding + +[Term] +id: GO:0032184 +name: SUMO polymer binding +namespace: molecular_function +def: "Interacting selectively with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah] +synonym: "Smt3 polymer binding" EXACT [] +is_a: GO:0032183 ! SUMO binding + +[Term] +id: GO:0032185 +name: septin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] +subset: gosubset_prok +synonym: "septin cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0032186 +name: cellular bud neck septin ring organization +namespace: biological_process +def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah] +is_a: GO:0031106 ! septin ring organization +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0010687 ! cytokinesis during cell cycle, site selection + +[Term] +id: GO:0032187 +name: contractile ring localization +namespace: biological_process +def: "The process by which a contractile ring is assembled and/or maintained in a specific location." [GOC:mah] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0032188 +name: establishment of contractile ring localization +namespace: biological_process +def: "The process by which a contractile ring is assembled in a specific location." [GOC:mah] +is_a: GO:0032187 ! contractile ring localization +relationship: part_of GO:0000915 ! cytokinesis, contractile ring formation +relationship: part_of GO:0007105 ! cytokinesis, site selection + +[Term] +id: GO:0032189 +name: maintenance of contractile ring localization +namespace: biological_process +def: "Any process by which a contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] +synonym: "cytokinetic ring anchoring" RELATED [] +is_a: GO:0032187 ! contractile ring localization +relationship: part_of GO:0031566 ! contractile ring maintenance involved in cytokinesis + +[Term] +id: GO:0032190 +name: acrosin binding +namespace: molecular_function +def: "Interacting selectively with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0032191 +name: acrosin heavy chain binding +namespace: molecular_function +def: "Interacting selectively with the larger of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221] +is_a: GO:0032190 ! acrosin binding + +[Term] +id: GO:0032192 +name: acrosin light chain binding +namespace: molecular_function +def: "Interacting selectively with the smaller of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221] +is_a: GO:0032190 ! acrosin binding + +[Term] +id: GO:0032193 +name: ubiquinone biosynthetic process via 2-polyprenylphenol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032194 +name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032195 +name: post-lysosomal vacuole +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012] +is_a: GO:0005773 ! vacuole +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0032196 +name: transposition +namespace: biological_process +def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0032197 +name: transposition, RNA-mediated +namespace: biological_process +alt_id: GO:0006319 +alt_id: GO:0006320 +alt_id: GO:0006321 +alt_id: GO:0006322 +def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090] +subset: gosubset_prok +synonym: "Class I transposition" EXACT [] +synonym: "retrotransposition" EXACT [] +synonym: "retrotransposon transposition" EXACT [] +synonym: "Tf transposition" NARROW [] +synonym: "Ty element transposition" NARROW [] +synonym: "Ty1 element transposition" NARROW [] +synonym: "Ty2 element transposition" NARROW [] +synonym: "Ty3 element transposition" NARROW [] +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0032198 +name: MITE transposition +namespace: biological_process +def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090] +synonym: "Class III transposition" EXACT [] +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0032199 +name: transcription during RNA-mediated transposition +namespace: biological_process +def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, ISBN:1555812090] +synonym: "reverse transcription during retrotransposition" EXACT [] +is_a: GO:0032197 ! transposition, RNA-mediated +relationship: part_of GO:0006410 ! transcription, RNA-dependent + +[Term] +id: GO:0032200 +name: telomere organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] +synonym: "chromosome organization, telomeric" EXACT [] +synonym: "organization of chromosome, telomeric region" EXACT [] +synonym: "telomere organization and biogenesis" EXACT [] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0032201 +name: telomere maintenance via semi-conservative replication +namespace: biological_process +def: "The process whereby telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors." [GOC:vw, PMID:16598261] +synonym: "equal telomere replication" RELATED [] +synonym: "telomeric fork progression" NARROW [] +synonym: "telomeric replication fork progression" NARROW [] +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0032202 +name: telomere assembly +namespace: biological_process +def: "The creation of a telomere at a non-telomeric double-stranded DNA end." [GOC:ns, PMID:11902675, PMID:8622671] +synonym: "telomere formation" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0032200 ! telomere organization + +[Term] +id: GO:0032203 +name: telomere formation via telomerase +namespace: biological_process +def: "The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase." [GOC:ns, PMID:11902675, PMID:8622671] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0032202 ! telomere assembly + +[Term] +id: GO:0032204 +name: regulation of telomere maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0000723 ! telomere maintenance + +[Term] +id: GO:0032205 +name: negative regulation of telomere maintenance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] +synonym: "down regulation of telomere maintenance" EXACT [] +synonym: "down-regulation of telomere maintenance" EXACT [] +synonym: "downregulation of telomere maintenance" EXACT [] +synonym: "inhibition of telomere maintenance" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0000723 ! telomere maintenance + +[Term] +id: GO:0032206 +name: positive regulation of telomere maintenance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] +synonym: "activation of telomere maintenance" NARROW [] +synonym: "stimulation of telomere maintenance" NARROW [] +synonym: "up regulation of telomere maintenance" EXACT [] +synonym: "up-regulation of telomere maintenance" EXACT [] +synonym: "upregulation of telomere maintenance" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0000723 ! telomere maintenance + +[Term] +id: GO:0032207 +name: regulation of telomere maintenance via recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0032208 +name: negative regulation of telomere maintenance via recombination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] +synonym: "down regulation of telomere maintenance via recombination" EXACT [] +synonym: "down-regulation of telomere maintenance via recombination" EXACT [] +synonym: "downregulation of telomere maintenance via recombination" EXACT [] +synonym: "inhibition of telomere maintenance via recombination" NARROW [] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:0032207 ! regulation of telomere maintenance via recombination +is_a: GO:0045950 ! negative regulation of mitotic recombination +relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0032209 +name: positive regulation of telomere maintenance via recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] +synonym: "activation of telomere maintenance via recombination" NARROW [] +synonym: "stimulation of telomere maintenance via recombination" NARROW [] +synonym: "up regulation of telomere maintenance via recombination" EXACT [] +synonym: "up-regulation of telomere maintenance via recombination" EXACT [] +synonym: "upregulation of telomere maintenance via recombination" EXACT [] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:0032207 ! regulation of telomere maintenance via recombination +is_a: GO:0045951 ! positive regulation of mitotic recombination +relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0032210 +name: regulation of telomere maintenance via telomerase +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0007004 ! telomere maintenance via telomerase + +[Term] +id: GO:0032211 +name: negative regulation of telomere maintenance via telomerase +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] +synonym: "down regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "downregulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "inhibition of telomere maintenance via telomerase" NARROW [] +is_a: GO:0008156 ! negative regulation of DNA replication +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:0032210 ! regulation of telomere maintenance via telomerase +relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase + +[Term] +id: GO:0032212 +name: positive regulation of telomere maintenance via telomerase +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] +synonym: "activation of telomere maintenance via telomerase" NARROW [] +synonym: "stimulation of telomere maintenance via telomerase" NARROW [] +synonym: "up regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "upregulation of telomere maintenance via telomerase activity" EXACT [] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:0032210 ! regulation of telomere maintenance via telomerase +is_a: GO:0045740 ! positive regulation of DNA replication +relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase + +[Term] +id: GO:0032213 +name: regulation of telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication + +[Term] +id: GO:0032214 +name: negative regulation of telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] +synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW [] +is_a: GO:0008156 ! negative regulation of DNA replication +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication +relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication + +[Term] +id: GO:0032215 +name: positive regulation of telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] +synonym: "activation of telomere maintenance via semi-conservative replication" NARROW [] +synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW [] +synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT [] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication +is_a: GO:0045740 ! positive regulation of DNA replication +relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication + +[Term] +id: GO:0032216 +name: glucosaminyl-phosphotidylinositol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [Reactome:REACT_1049.1] +synonym: "GPI-inositol acyltransferase" RELATED [] +xref: EC:2.3.1.- +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0032217 +name: riboflavin transporter activity +namespace: molecular_function +def: "Facilitates the directed movement of riboflavin into, out of, within or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0032218 +name: riboflavin transport +namespace: biological_process +def: "The directed movement of riboflavin into, out of, within or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0032219 +name: cell wall catabolic process during cytogamy +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cell wall during cytogamy." [GOC:mah] +is_a: GO:0016998 ! cell wall catabolic process +relationship: part_of GO:0000755 ! cytogamy + +[Term] +id: GO:0032220 +name: plasma membrane fusion during cytogamy +namespace: biological_process +def: "The joining of two or more lipid bilayer membranes that surround cells, during cytogamy." [GOC:mah] +is_a: GO:0045026 ! plasma membrane fusion +relationship: part_of GO:0000755 ! cytogamy + +[Term] +id: GO:0032221 +name: Clr6 histone deacetylase complex II' +namespace: cellular_component +def: "A eukaryotically conserved histone deacetylse complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0032222 +name: regulation of synaptic transmission, cholinergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] +is_a: GO:0050804 ! regulation of synaptic transmission +relationship: regulates GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0032223 +name: negative regulation of synaptic transmission, cholinergic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] +synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] +synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] +is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0032224 +name: positive regulation of synaptic transmission, cholinergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] +synonym: "activation of synaptic transmission, cholinergic" NARROW [] +synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] +synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] +is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0032225 +name: regulation of synaptic transmission, dopaminergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] +is_a: GO:0050804 ! regulation of synaptic transmission +relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0032226 +name: positive regulation of synaptic transmission, dopaminergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] +synonym: "activation of synaptic transmission, dopaminergic" NARROW [] +synonym: "stimulation of synaptic transmission, dopaminergic" NARROW [] +synonym: "up regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "upregulation of synaptic transmission, dopaminergic" EXACT [] +is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0032227 +name: negative regulation of synaptic transmission, dopaminergic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] +synonym: "down regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "downregulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "inhibition of synaptic transmission, dopaminergic" NARROW [] +is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0032228 +name: regulation of synaptic transmission, GABAergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] +is_a: GO:0050804 ! regulation of synaptic transmission +relationship: regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032229 +name: negative regulation of synaptic transmission, GABAergic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] +synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] +synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] +is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032230 +name: positive regulation of synaptic transmission, GABAergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] +synonym: "activation of synaptic transmission, GABAergic" NARROW [] +synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] +synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] +is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032231 +name: regulation of actin filament bundle formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0032232 +name: negative regulation of actin filament bundle formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "down regulation of actin filament bundle formation" EXACT [] +synonym: "down-regulation of actin filament bundle formation" EXACT [] +synonym: "downregulation of actin filament bundle formation" EXACT [] +synonym: "inhibition of actin filament bundle formation" NARROW [] +is_a: GO:0032231 ! regulation of actin filament bundle formation +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0032233 +name: positive regulation of actin filament bundle formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "activation of actin filament bundle formation" NARROW [] +synonym: "stimulation of actin filament bundle formation" NARROW [] +synonym: "up regulation of actin filament bundle formation" EXACT [] +synonym: "up-regulation of actin filament bundle formation" EXACT [] +synonym: "upregulation of actin filament bundle formation" EXACT [] +is_a: GO:0032231 ! regulation of actin filament bundle formation +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0032234 +name: regulation of calcium ion transport via store-operated calcium channel +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] +synonym: "regulation of calcium transport via store-operated calcium channel" EXACT [] +synonym: "regulation of store-operated calcium channel activity" EXACT [] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0051924 ! regulation of calcium ion transport + +[Term] +id: GO:0032235 +name: negative regulation of calcium ion transport via store-operated calcium channel +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] +synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW [] +synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT [] +synonym: "negative regulation of store-operated calcium channel activity" EXACT [] +is_a: GO:0032234 ! regulation of calcium ion transport via store-operated calcium channel +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0051926 ! negative regulation of calcium ion transport + +[Term] +id: GO:0032236 +name: positive regulation of calcium ion transport via store-operated calcium channel +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] +synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW [] +synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT [] +synonym: "positive regulation of store-operated calcium channel activity" EXACT [] +synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW [] +synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT [] +is_a: GO:0032234 ! regulation of calcium ion transport via store-operated calcium channel +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:0051928 ! positive regulation of calcium ion transport + +[Term] +id: GO:0032237 +name: activation of store-operated calcium channel activity +namespace: biological_process +def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah] +is_a: GO:0032236 ! positive regulation of calcium ion transport via store-operated calcium channel + +[Term] +id: GO:0032238 +name: adenosine transport +namespace: biological_process +def: "The directed movement of adenosine, adenine riboside, into, out of, within or between cells." [GOC:mah] +subset: gosubset_prok +is_a: GO:0015860 ! purine nucleoside transport + +[Term] +id: GO:0032239 +name: regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0032240 +name: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] +is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0032241 +name: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells." [GOC:mah] +synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] +synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] +synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0032242 +name: regulation of nucleoside transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells." [GOC:mah] +is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +relationship: regulates GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032243 +name: negative regulation of nucleoside transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of nucleoside transport" EXACT [] +synonym: "down-regulation of nucleoside transport" EXACT [] +synonym: "downregulation of nucleoside transport" EXACT [] +synonym: "inhibition of nucleoside transport" NARROW [] +is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: negatively_regulates GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032244 +name: positive regulation of nucleoside transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells." [GOC:mah] +synonym: "activation of nucleoside transport" NARROW [] +synonym: "stimulation of nucleoside transport" NARROW [] +synonym: "up regulation of nucleoside transport" EXACT [] +synonym: "up-regulation of nucleoside transport" EXACT [] +synonym: "upregulation of nucleoside transport" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: positively_regulates GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032245 +name: regulation of purine nucleoside transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells." [GOC:mah] +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: regulates GO:0015860 ! purine nucleoside transport + +[Term] +id: GO:0032246 +name: regulation of pyrimidine nucleoside transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of, within or between cells." [GOC:mah] +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: regulates GO:0015864 ! pyrimidine nucleoside transport + +[Term] +id: GO:0032247 +name: negative regulation of purine nucleoside transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of purine nucleoside transport" EXACT [] +synonym: "down-regulation of purine nucleoside transport" EXACT [] +synonym: "downregulation of purine nucleoside transport" EXACT [] +synonym: "inhibition of purine nucleoside transport" NARROW [] +is_a: GO:0032243 ! negative regulation of nucleoside transport +is_a: GO:0032245 ! regulation of purine nucleoside transport +relationship: negatively_regulates GO:0015860 ! purine nucleoside transport + +[Term] +id: GO:0032248 +name: positive regulation of purine nucleoside transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells." [GOC:mah] +synonym: "activation of purine nucleoside transport" NARROW [] +synonym: "stimulation of purine nucleoside transport" NARROW [] +synonym: "up regulation of purine nucleoside transport" EXACT [] +synonym: "up-regulation of purine nucleoside transport" EXACT [] +synonym: "upregulation of purine nucleoside transport" EXACT [] +is_a: GO:0032244 ! positive regulation of nucleoside transport +is_a: GO:0032245 ! regulation of purine nucleoside transport +relationship: positively_regulates GO:0015860 ! purine nucleoside transport + +[Term] +id: GO:0032249 +name: regulation of adenosine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells." [GOC:mah] +is_a: GO:0032245 ! regulation of purine nucleoside transport +relationship: regulates GO:0032238 ! adenosine transport + +[Term] +id: GO:0032250 +name: negative regulation of adenosine transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of adenosine transport" EXACT [] +synonym: "down-regulation of adenosine transport" EXACT [] +synonym: "downregulation of adenosine transport" EXACT [] +synonym: "inhibition of adenosine transport" NARROW [] +is_a: GO:0032247 ! negative regulation of purine nucleoside transport +is_a: GO:0032249 ! regulation of adenosine transport +relationship: negatively_regulates GO:0032238 ! adenosine transport + +[Term] +id: GO:0032251 +name: positive regulation of adenosine transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells." [GOC:mah] +synonym: "activation of adenosine transport" NARROW [] +synonym: "stimulation of adenosine transport" NARROW [] +synonym: "up regulation of adenosine transport" EXACT [] +synonym: "up-regulation of adenosine transport" EXACT [] +synonym: "upregulation of adenosine transport" EXACT [] +is_a: GO:0032248 ! positive regulation of purine nucleoside transport +is_a: GO:0032249 ! regulation of adenosine transport +relationship: positively_regulates GO:0032238 ! adenosine transport + +[Term] +id: GO:0032252 +name: secretory granule localization +namespace: biological_process +def: "Any process by which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] +synonym: "secretory granule clustering" RELATED [] +is_a: GO:0051648 ! vesicle localization + +[Term] +id: GO:0032253 +name: dense core granule localization +namespace: biological_process +def: "Any process by which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] +synonym: "dense core granule clustering" RELATED [] +is_a: GO:0032252 ! secretory granule localization + +[Term] +id: GO:0032254 +name: establishment of secretory granule localization +namespace: biological_process +def: "The directed movement of a secretory granule to a specific location." [GOC:mah] +is_a: GO:0051650 ! establishment of vesicle localization +relationship: part_of GO:0032252 ! secretory granule localization + +[Term] +id: GO:0032255 +name: maintenance of secretory granule location +namespace: biological_process +def: "Any process by which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051655 ! maintenance of vesicle location +relationship: part_of GO:0032252 ! secretory granule localization + +[Term] +id: GO:0032256 +name: establishment of dense core granule localization +namespace: biological_process +def: "The directed movement of a dense core granule to a specific location." [GOC:mah] +is_a: GO:0032254 ! establishment of secretory granule localization +relationship: part_of GO:0032253 ! dense core granule localization + +[Term] +id: GO:0032257 +name: maintenance of dense core granule location +namespace: biological_process +def: "Any process by which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032255 ! maintenance of secretory granule location +relationship: part_of GO:0032253 ! dense core granule localization + +[Term] +id: GO:0032258 +name: CVT pathway +namespace: biological_process +def: "A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643] +synonym: "cytoplasm to vacuole targeting" EXACT [] +synonym: "cytoplasm-to-vacuole targeting" EXACT [] +is_a: GO:0006623 ! protein targeting to vacuole +relationship: part_of GO:0006914 ! autophagy + +[Term] +id: GO:0032259 +name: methylation +namespace: biological_process +def: "The process by which a methyl group is covalently attached to a molecule." [GOC:mah] +is_a: GO:0006730 ! one-carbon compound metabolic process + +[Term] +id: GO:0032260 +name: response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah] +is_a: GO:0009753 ! response to jasmonic acid stimulus +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0032261 +name: purine nucleotide salvage +namespace: biological_process +def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0043101 ! purine salvage +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0032262 +name: pyrimidine nucleotide salvage +namespace: biological_process +def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0008655 ! pyrimidine salvage +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0032263 +name: GMP salvage +namespace: biological_process +def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0032261 ! purine nucleotide salvage + +[Term] +id: GO:0032264 +name: IMP salvage +namespace: biological_process +def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0032261 ! purine nucleotide salvage + +[Term] +id: GO:0032265 +name: XMP salvage +namespace: biological_process +def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0032261 ! purine nucleotide salvage + +[Term] +id: GO:0032266 +name: phosphatidylinositol 3-phosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol 3-phosphate, a phosphorylated derivative of phosphatidylinositol." [PMID:11557775] +synonym: "PtdIns-3-P binding" EXACT [] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0032267 +name: tRNA(Ile)-lysidine synthase +namespace: molecular_function +def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414] +synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT [] +synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT [] +xref: EC:6.3.4.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0032268 +name: regulation of cellular protein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of cellular protein metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0032269 +name: negative regulation of cellular protein metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +synonym: "down regulation of cellular protein metabolic process" EXACT [] +synonym: "down-regulation of cellular protein metabolic process" EXACT [] +synonym: "downregulation of cellular protein metabolic process" EXACT [] +synonym: "inhibition of cellular protein metabolic process" NARROW [] +synonym: "negative regulation of cellular protein metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0032270 +name: positive regulation of cellular protein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +synonym: "activation of cellular protein metabolic process" NARROW [] +synonym: "positive regulation of cellular protein metabolism" EXACT [] +synonym: "stimulation of cellular protein metabolic process" NARROW [] +synonym: "up regulation of cellular protein metabolic process" EXACT [] +synonym: "up-regulation of cellular protein metabolic process" EXACT [] +synonym: "upregulation of cellular protein metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0032271 +name: regulation of protein polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] +synonym: "regulation of protein polymerisation" EXACT [] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0043254 ! regulation of protein complex assembly +relationship: regulates GO:0051258 ! protein polymerization + +[Term] +id: GO:0032272 +name: negative regulation of protein polymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] +synonym: "down regulation of protein polymerization" EXACT [] +synonym: "down-regulation of protein polymerization" EXACT [] +synonym: "downregulation of protein polymerization" EXACT [] +synonym: "inhibition of protein polymerization" NARROW [] +is_a: GO:0031333 ! negative regulation of protein complex assembly +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0032271 ! regulation of protein polymerization +relationship: negatively_regulates GO:0051258 ! protein polymerization + +[Term] +id: GO:0032273 +name: positive regulation of protein polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] +synonym: "activation of protein polymerization" NARROW [] +synonym: "stimulation of protein polymerization" NARROW [] +synonym: "up regulation of protein polymerization" EXACT [] +synonym: "up-regulation of protein polymerization" EXACT [] +synonym: "upregulation of protein polymerization" EXACT [] +is_a: GO:0031334 ! positive regulation of protein complex assembly +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0032271 ! regulation of protein polymerization +relationship: positively_regulates GO:0051258 ! protein polymerization + +[Term] +id: GO:0032274 +name: gonadotropin secretion +namespace: biological_process +def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "gonadotrophin secretion" EXACT [] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0032275 +name: luteinizing hormone secretion +namespace: biological_process +def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032276 +name: regulation of gonadotropin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] +synonym: "regulation of gonadotrophin secretion" EXACT [] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032277 +name: negative regulation of gonadotropin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] +synonym: "down regulation of gonadotropin secretion" EXACT [] +synonym: "down-regulation of gonadotropin secretion" EXACT [] +synonym: "downregulation of gonadotropin secretion" EXACT [] +synonym: "inhibition of gonadotropin secretion" NARROW [] +synonym: "negative regulation of gonadotrophin secretion" EXACT [] +is_a: GO:0032276 ! regulation of gonadotropin secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032278 +name: positive regulation of gonadotropin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] +synonym: "activation of gonadotropin secretion" NARROW [] +synonym: "positive regulation of gonadotrophin secretion" EXACT [] +synonym: "stimulation of gonadotropin secretion" NARROW [] +synonym: "up regulation of gonadotropin secretion" EXACT [] +synonym: "up-regulation of gonadotropin secretion" EXACT [] +synonym: "upregulation of gonadotropin secretion" EXACT [] +is_a: GO:0032276 ! regulation of gonadotropin secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032279 +name: asymmetric synapse +namespace: cellular_component +def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density." [GOC:dgh, GOC:ef] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0032280 +name: symmetric synapse +namespace: cellular_component +def: "A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density." [GOC:dgh, GOC:ef] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0032281 +name: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex +namespace: cellular_component +def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] +synonym: "AMPA receptor " RELATED [] +synonym: "AMPA-selective glutamate receptor complex" EXACT [] +is_a: GO:0008328 ! ionotropic glutamate receptor complex + +[Term] +id: GO:0032282 +name: plastid acetyl-CoA carboxylase complex +namespace: cellular_component +def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah] +synonym: "plastid ACCase complex" EXACT [] +is_a: GO:0009317 ! acetyl-CoA carboxylase complex +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009532 ! plastid stroma + +[Term] +id: GO:0032283 +name: plastid acetate CoA-transferase complex +namespace: cellular_component +def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah] +is_a: GO:0009329 ! acetate CoA-transferase complex +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex + +[Term] +id: GO:0032284 +name: plastid biotin carboxylase complex +namespace: cellular_component +def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah] +is_a: GO:0009343 ! biotin carboxylase complex +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex + +[Term] +id: GO:0032285 +name: ensheathment of non-myelinated axons +namespace: biological_process +def: "The process by which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0032286 +name: myelin maintenance in the central nervous system +namespace: biological_process +def: "The process by which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh] +is_a: GO:0043217 ! myelin maintenance +relationship: part_of GO:0022010 ! myelination in the central nervous system + +[Term] +id: GO:0032287 +name: myelin maintenance in the peripheral nervous system +namespace: biological_process +def: "The process by which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh] +is_a: GO:0043217 ! myelin maintenance +relationship: part_of GO:0022011 ! myelination in the peripheral nervous system + +[Term] +id: GO:0032288 +name: myelin formation +namespace: biological_process +def: "The process by which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0042552 ! myelination + +[Term] +id: GO:0032289 +name: myelin formation in the central nervous system +namespace: biological_process +def: "The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] +is_a: GO:0032288 ! myelin formation +relationship: part_of GO:0022010 ! myelination in the central nervous system + +[Term] +id: GO:0032290 +name: myelin formation in the peripheral nervous system +namespace: biological_process +def: "The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system." [GOC:dgh] +is_a: GO:0032288 ! myelin formation +relationship: part_of GO:0022011 ! myelination in the peripheral nervous system + +[Term] +id: GO:0032291 +name: ensheathment of axons in the central nervous system +namespace: biological_process +def: "The process by which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0032292 +name: ensheathment of axons in the peripheral nervous system +namespace: biological_process +def: "The process by which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0032293 +name: ensheathment of non-myelinated axons in the central nervous system +namespace: biological_process +def: "The process by which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh] +is_a: GO:0032285 ! ensheathment of non-myelinated axons +is_a: GO:0032291 ! ensheathment of axons in the central nervous system + +[Term] +id: GO:0032294 +name: ensheathment of non-myelinated axons in the peripheral nervous system +namespace: biological_process +def: "The process by which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh] +is_a: GO:0032285 ! ensheathment of non-myelinated axons +is_a: GO:0032292 ! ensheathment of axons in the peripheral nervous system + +[Term] +id: GO:0032295 +name: ensheathment of neuronal cell bodies +namespace: biological_process +def: "The process by which satellite glial cells isolate neuronal cell bodies." [GOC:dgh] +is_a: GO:0007272 ! ensheathment of neurons + +[Term] +id: GO:0032296 +name: double-stranded RNA-specific ribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah] +synonym: "double-stranded RNA-specific RNase activity" EXACT [] +synonym: "dsRNA-specific ribonuclease activity" EXACT [] +synonym: "dsRNA-specific RNase activity" EXACT [] +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0032297 +name: negative regulation of DNA replication initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication." [GOC:mah] +synonym: "down regulation of DNA replication initiation" EXACT [] +synonym: "down-regulation of DNA replication initiation" EXACT [] +synonym: "downregulation of DNA replication initiation" EXACT [] +synonym: "inhibition of DNA replication initiation" NARROW [] +is_a: GO:0008156 ! negative regulation of DNA replication +is_a: GO:0030174 ! regulation of DNA replication initiation +relationship: negatively_regulates GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0032298 +name: positive regulation of DNA replication initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA replication." [GOC:mah] +synonym: "activation of DNA replication initiation" NARROW [] +synonym: "stimulation of DNA replication initiation" NARROW [] +synonym: "up regulation of DNA replication initiation" EXACT [] +synonym: "up-regulation of DNA replication initiation" EXACT [] +synonym: "upregulation of DNA replication initiation" EXACT [] +is_a: GO:0030174 ! regulation of DNA replication initiation +is_a: GO:0045740 ! positive regulation of DNA replication +relationship: positively_regulates GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0032299 +name: ribonuclease H2 complex +namespace: cellular_component +def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815] +synonym: "RNase H2 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0032300 +name: mismatch repair complex +namespace: cellular_component +def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0032301 +name: MutSalpha complex +namespace: cellular_component +def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] +synonym: "MMR complex" BROAD [] +synonym: "MSH2/MSH6 complex" EXACT [] +is_a: GO:0032300 ! mismatch repair complex + +[Term] +id: GO:0032302 +name: MutSbeta complex +namespace: cellular_component +def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] +synonym: "MMR complex" BROAD [] +synonym: "MSH2/MSH3 complex" EXACT [] +is_a: GO:0032300 ! mismatch repair complex + +[Term] +id: GO:0032303 +name: regulation of icosanoid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of an icosanoid from a cell or group of cells." [GOC:mah] +synonym: "regulation of eicosanoid secretion" EXACT [] +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032304 +name: negative regulation of icosanoid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of an icosanoid from a cell or group of cells." [GOC:mah] +synonym: "down regulation of icosanoid secretion" EXACT [] +synonym: "down-regulation of icosanoid secretion" EXACT [] +synonym: "downregulation of icosanoid secretion" EXACT [] +synonym: "inhibition of icosanoid secretion" NARROW [] +synonym: "negative regulation of eicosanoid secretion" EXACT [] +is_a: GO:0032303 ! regulation of icosanoid secretion +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032305 +name: positive regulation of icosanoid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of an icosanoid from a cell or group of cells." [GOC:mah] +synonym: "activation of icosanoid secretion" NARROW [] +synonym: "positive regulation of eicosanoid secretion" EXACT [] +synonym: "stimulation of icosanoid secretion" NARROW [] +synonym: "up regulation of icosanoid secretion" EXACT [] +synonym: "up-regulation of icosanoid secretion" EXACT [] +synonym: "upregulation of icosanoid secretion" EXACT [] +is_a: GO:0032303 ! regulation of icosanoid secretion +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032306 +name: regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah] +synonym: "regulation of prostacyclin secretion" NARROW [] +is_a: GO:0032303 ! regulation of icosanoid secretion +is_a: GO:0032890 ! regulation of organic acid transport +relationship: regulates GO:0032310 ! prostaglandin secretion + +[Term] +id: GO:0032307 +name: negative regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah] +synonym: "down regulation of prostaglandin secretion" EXACT [] +synonym: "down-regulation of prostaglandin secretion" EXACT [] +synonym: "downregulation of prostaglandin secretion" EXACT [] +synonym: "inhibition of prostaglandin secretion" NARROW [] +synonym: "negative regulation of prostacyclin secretion" NARROW [] +is_a: GO:0032304 ! negative regulation of icosanoid secretion +is_a: GO:0032306 ! regulation of prostaglandin secretion +is_a: GO:0032891 ! negative regulation of organic acid transport +relationship: negatively_regulates GO:0032310 ! prostaglandin secretion + +[Term] +id: GO:0032308 +name: positive regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah] +synonym: "activation of prostaglandin secretion" NARROW [] +synonym: "positive regulation of prostacyclin secretion" NARROW [] +synonym: "stimulation of prostaglandin secretion" NARROW [] +synonym: "up regulation of prostaglandin secretion" EXACT [] +synonym: "up-regulation of prostaglandin secretion" EXACT [] +synonym: "upregulation of prostaglandin secretion" EXACT [] +is_a: GO:0032305 ! positive regulation of icosanoid secretion +is_a: GO:0032306 ! regulation of prostaglandin secretion +is_a: GO:0032892 ! positive regulation of organic acid transport +relationship: positively_regulates GO:0032310 ! prostaglandin secretion + +[Term] +id: GO:0032309 +name: icosanoid secretion +namespace: biological_process +def: "The regulated release of icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:mah] +synonym: "eicosanoid secretion" EXACT [] +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0032310 +name: prostaglandin secretion +namespace: biological_process +def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:mah] +synonym: "prostacyclin secretion" NARROW [] +is_a: GO:0015732 ! prostaglandin transport +is_a: GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032311 +name: angiogenin-PRI complex +namespace: cellular_component +def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] +synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0032312 +name: regulation of ARF GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of the GTPase ARF." [GOC:mah] +is_a: GO:0032318 ! regulation of Ras GTPase activity +relationship: part_of GO:0032012 ! regulation of ARF protein signal transduction + +[Term] +id: GO:0032313 +name: regulation of Rab GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah] +is_a: GO:0032318 ! regulation of Ras GTPase activity +relationship: part_of GO:0032483 ! regulation of Rab protein signal transduction + +[Term] +id: GO:0032314 +name: regulation of Rac GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Rac family." [GOC:mah] +is_a: GO:0032319 ! regulation of Rho GTPase activity +relationship: part_of GO:0035020 ! regulation of Rac protein signal transduction + +[Term] +id: GO:0032315 +name: regulation of Ral GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Ral family." [GOC:mah] +is_a: GO:0032318 ! regulation of Ras GTPase activity +relationship: part_of GO:0032485 ! regulation of Ral protein signal transduction + +[Term] +id: GO:0032316 +name: regulation of Ran GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Ran family." [GOC:mah] +is_a: GO:0032318 ! regulation of Ras GTPase activity +relationship: part_of GO:0032015 ! regulation of Ran protein signal transduction + +[Term] +id: GO:0032317 +name: regulation of Rap GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Rap family." [GOC:mah] +is_a: GO:0032318 ! regulation of Ras GTPase activity +relationship: part_of GO:0032487 ! regulation of Rap protein signal transduction + +[Term] +id: GO:0032318 +name: regulation of Ras GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Ras superfamily." [GOC:mah] +is_a: GO:0043087 ! regulation of GTPase activity +relationship: part_of GO:0046578 ! regulation of Ras protein signal transduction + +[Term] +id: GO:0032319 +name: regulation of Rho GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of a GTPase of the Rho family." [GOC:mah] +is_a: GO:0032318 ! regulation of Ras GTPase activity +relationship: part_of GO:0035023 ! regulation of Rho protein signal transduction + +[Term] +id: GO:0032320 +name: positive regulation of Ras GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Ras superfamily." [GOC:mah] +synonym: "stimulation of Ras GTPase activity" NARROW [] +synonym: "up regulation of Ras GTPase activity" EXACT [] +synonym: "up-regulation of Ras GTPase activity" EXACT [] +synonym: "upregulation of Ras GTPase activity" EXACT [] +is_a: GO:0032318 ! regulation of Ras GTPase activity +is_a: GO:0043547 ! positive regulation of GTPase activity + +[Term] +id: GO:0032321 +name: positive regulation of Rho GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Rho family." [GOC:mah] +synonym: "stimulation of Rho GTPase activity" NARROW [] +synonym: "up regulation of Rho GTPase activity" EXACT [] +synonym: "up-regulation of Rho GTPase activity" EXACT [] +synonym: "upregulation of Rho GTPase activity" EXACT [] +is_a: GO:0032319 ! regulation of Rho GTPase activity +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032322 +name: ubiquinone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +synonym: "ubiquinone breakdown" EXACT [] +synonym: "ubiquinone catabolism" EXACT [] +synonym: "ubiquinone degradation" EXACT [] +is_a: GO:0006743 ! ubiquinone metabolic process +is_a: GO:0042378 ! quinone cofactor catabolic process + +[Term] +id: GO:0032323 +name: lipoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:mah] +synonym: "lipoic acid breakdown" EXACT [] +synonym: "lipoic acid catabolism" EXACT [] +synonym: "lipoic acid degradation" EXACT [] +is_a: GO:0000273 ! lipoic acid metabolic process + +[Term] +id: GO:0032324 +name: molybdopterin cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] +synonym: "molybdopterin cofactor anabolism" EXACT [] +synonym: "molybdopterin cofactor biosynthesis" RELATED [] +synonym: "molybdopterin cofactor formation" RELATED [] +synonym: "molybdopterin cofactor synthesis" EXACT [] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process + +[Term] +id: GO:0032325 +name: molybdopterin cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process + +[Term] +id: GO:0032326 +name: Mo-molybdopterin cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah] +subset: gosubset_prok +synonym: "Mo-molybdopterin cofactor breakdown" EXACT [] +synonym: "Mo-molybdopterin cofactor catabolism" EXACT [] +synonym: "Mo-molybdopterin cofactor degradation" EXACT [] +synonym: "Moco catabolic process" BROAD [] +synonym: "Moco catabolism" BROAD [] +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process +is_a: GO:0032325 ! molybdopterin cofactor catabolic process +is_a: GO:0042559 ! pteridine and derivative biosynthetic process + +[Term] +id: GO:0032327 +name: W-molybdopterin cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah] +subset: gosubset_prok +synonym: "Moco catabolic process" BROAD [] +synonym: "Moco catabolism" BROAD [] +synonym: "W-molybdopterin cofactor breakdown" EXACT [] +synonym: "W-molybdopterin cofactor catabolism" EXACT [] +synonym: "W-molybdopterin cofactor degradation" EXACT [] +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0032325 ! molybdopterin cofactor catabolic process +is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process +is_a: GO:0042559 ! pteridine and derivative biosynthetic process + +[Term] +id: GO:0032328 +name: alanine transport +namespace: biological_process +def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of, within or between cells." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0032329 +name: serine transport +namespace: biological_process +def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0032330 +name: regulation of chondrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0032331 +name: negative regulation of chondrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] +synonym: "down regulation of chondrocyte differentiation" EXACT [] +synonym: "down-regulation of chondrocyte differentiation" EXACT [] +synonym: "downregulation of chondrocyte differentiation" EXACT [] +synonym: "inhibition of chondrocyte differentiation" NARROW [] +is_a: GO:0032330 ! regulation of chondrocyte differentiation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0032332 +name: positive regulation of chondrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] +synonym: "activation of chondrocyte differentiation" NARROW [] +synonym: "stimulation of chondrocyte differentiation" NARROW [] +synonym: "up regulation of chondrocyte differentiation" EXACT [] +synonym: "up-regulation of chondrocyte differentiation" EXACT [] +synonym: "upregulation of chondrocyte differentiation" EXACT [] +is_a: GO:0032330 ! regulation of chondrocyte differentiation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0032333 +name: activin secretion +namespace: biological_process +def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0032334 +name: inhibin secretion +namespace: biological_process +def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0032335 +name: regulation of activin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0032333 ! activin secretion + +[Term] +id: GO:0032336 +name: negative regulation of activin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah] +synonym: "down regulation of activin secretion" EXACT [] +synonym: "down-regulation of activin secretion" EXACT [] +synonym: "downregulation of activin secretion" EXACT [] +synonym: "inhibition of activin secretion" NARROW [] +is_a: GO:0032335 ! regulation of activin secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0032333 ! activin secretion + +[Term] +id: GO:0032337 +name: positive regulation of activin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah] +synonym: "activation of activin secretion" NARROW [] +synonym: "stimulation of activin secretion" NARROW [] +synonym: "up regulation of activin secretion" EXACT [] +synonym: "up-regulation of activin secretion" EXACT [] +synonym: "upregulation of activin secretion" EXACT [] +is_a: GO:0032335 ! regulation of activin secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0032333 ! activin secretion + +[Term] +id: GO:0032338 +name: regulation of inhibin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0032334 ! inhibin secretion + +[Term] +id: GO:0032339 +name: negative regulation of inhibin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah] +synonym: "down regulation of inhibin secretion" EXACT [] +synonym: "down-regulation of inhibin secretion" EXACT [] +synonym: "downregulation of inhibin secretion" EXACT [] +synonym: "inhibition of inhibin secretion" NARROW [] +is_a: GO:0032338 ! regulation of inhibin secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0032334 ! inhibin secretion + +[Term] +id: GO:0032340 +name: positive regulation of inhibin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah] +synonym: "activation of inhibin secretion" NARROW [] +synonym: "stimulation of inhibin secretion" NARROW [] +synonym: "up regulation of inhibin secretion" EXACT [] +synonym: "up-regulation of inhibin secretion" EXACT [] +synonym: "upregulation of inhibin secretion" EXACT [] +is_a: GO:0032338 ! regulation of inhibin secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0032334 ! inhibin secretion + +[Term] +id: GO:0032341 +name: aldosterone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] +synonym: "aldosterone metabolism" EXACT [] +is_a: GO:0008212 ! mineralocorticoid metabolic process + +[Term] +id: GO:0032342 +name: aldosterone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] +is_a: GO:0006705 ! mineralocorticoid biosynthetic process +is_a: GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032343 +name: aldosterone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] +is_a: GO:0006712 ! mineralocorticoid catabolic process +is_a: GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032344 +name: regulation of aldosterone metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] +synonym: "regulation of aldosterone metabolism" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032345 +name: negative regulation of aldosterone metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] +synonym: "down regulation of aldosterone metabolic process" EXACT [] +synonym: "down-regulation of aldosterone metabolic process" EXACT [] +synonym: "downregulation of aldosterone metabolic process" EXACT [] +synonym: "inhibition of aldosterone metabolic process" NARROW [] +synonym: "negative regulation of aldosterone metabolism" EXACT [] +is_a: GO:0032344 ! regulation of aldosterone metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032346 +name: positive regulation of aldosterone metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] +synonym: "activation of aldosterone metabolic process" NARROW [] +synonym: "positive regulation of aldosterone metabolism" EXACT [] +synonym: "stimulation of aldosterone metabolic process" NARROW [] +synonym: "up regulation of aldosterone metabolic process" EXACT [] +synonym: "up-regulation of aldosterone metabolic process" EXACT [] +synonym: "upregulation of aldosterone metabolic process" EXACT [] +is_a: GO:0032344 ! regulation of aldosterone metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +relationship: positively_regulates GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032347 +name: regulation of aldosterone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] +is_a: GO:0032344 ! regulation of aldosterone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0032342 ! aldosterone biosynthetic process + +[Term] +id: GO:0032348 +name: negative regulation of aldosterone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] +synonym: "down regulation of aldosterone biosynthetic process" EXACT [] +synonym: "down-regulation of aldosterone biosynthetic process" EXACT [] +synonym: "downregulation of aldosterone biosynthetic process" EXACT [] +synonym: "inhibition of aldosterone biosynthetic process" NARROW [] +is_a: GO:0032345 ! negative regulation of aldosterone metabolic process +is_a: GO:0032347 ! regulation of aldosterone biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process + +[Term] +id: GO:0032349 +name: positive regulation of aldosterone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] +synonym: "activation of aldosterone biosynthetic process" NARROW [] +synonym: "stimulation of aldosterone biosynthetic process" NARROW [] +synonym: "up regulation of aldosterone biosynthetic process" EXACT [] +synonym: "up-regulation of aldosterone biosynthetic process" EXACT [] +synonym: "upregulation of aldosterone biosynthetic process" EXACT [] +is_a: GO:0032346 ! positive regulation of aldosterone metabolic process +is_a: GO:0032347 ! regulation of aldosterone biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process + +[Term] +id: GO:0032350 +name: regulation of hormone metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] +synonym: "regulation of hormone metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0032351 +name: negative regulation of hormone metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] +synonym: "down regulation of hormone metabolic process" EXACT [] +synonym: "down-regulation of hormone metabolic process" EXACT [] +synonym: "downregulation of hormone metabolic process" EXACT [] +synonym: "inhibition of hormone metabolic process" NARROW [] +synonym: "negative regulation of hormone metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: negatively_regulates GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0032352 +name: positive regulation of hormone metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] +synonym: "activation of hormone metabolic process" NARROW [] +synonym: "positive regulation of hormone metabolism" EXACT [] +synonym: "stimulation of hormone metabolic process" NARROW [] +synonym: "up regulation of hormone metabolic process" EXACT [] +synonym: "up-regulation of hormone metabolic process" EXACT [] +synonym: "upregulation of hormone metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: positively_regulates GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0032353 +name: negative regulation of hormone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] +synonym: "down regulation of hormone biosynthetic process" EXACT [] +synonym: "down-regulation of hormone biosynthetic process" EXACT [] +synonym: "downregulation of hormone biosynthetic process" EXACT [] +synonym: "inhibition of hormone biosynthetic process" NARROW [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0032354 +name: response to follicle-stimulating hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] +is_a: GO:0034698 ! response to gonadotropin stimulus + +[Term] +id: GO:0032355 +name: response to estradiol stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] +synonym: "response to E2 stimulus" EXACT [] +is_a: GO:0043627 ! response to estrogen stimulus + +[Term] +id: GO:0032356 +name: oxidized DNA binding +namespace: molecular_function +def: "Interacting selectively with oxidized residues in DNA." [GOC:vk] +synonym: "oxidised DNA binding" EXACT [] +is_a: GO:0003684 ! damaged DNA binding + +[Term] +id: GO:0032357 +name: oxidized purine DNA binding +namespace: molecular_function +def: "Interacting selectively with oxidized purine residues in DNA." [GOC:vk] +synonym: "oxidised purine DNA binding" EXACT [] +is_a: GO:0032356 ! oxidized DNA binding + +[Term] +id: GO:0032358 +name: oxidized pyrimidine DNA binding +namespace: molecular_function +def: "Interacting selectively with oxidized pyrimidine residues in DNA." [GOC:vk] +synonym: "oxidised pyrimidine DNA binding" EXACT [] +is_a: GO:0032356 ! oxidized DNA binding + +[Term] +id: GO:0032359 +name: provirus excision +namespace: biological_process +def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg] +synonym: "prophage excision" EXACT [] +is_a: GO:0022415 ! viral reproductive process + +[Term] +id: GO:0032360 +name: provirus maintenance +namespace: biological_process +def: "The molecular events that maintain a viral genome integrated into a host genome." [GOC:mlg] +synonym: "prophage maintenance" EXACT [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0030069 ! lysogeny + +[Term] +id: GO:0032361 +name: pyridoxal phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah] +is_a: GO:0042820 ! vitamin B6 catabolic process +is_a: GO:0042822 ! pyridoxal phosphate metabolic process +is_a: GO:0051187 ! cofactor catabolic process + +[Term] +id: GO:0032362 +name: FAD catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0042728 ! riboflavin and derivative catabolic process +is_a: GO:0046443 ! FAD metabolic process + +[Term] +id: GO:0032363 +name: FMN catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0042728 ! riboflavin and derivative catabolic process +is_a: GO:0046444 ! FMN metabolic process + +[Term] +id: GO:0032364 +name: oxygen homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium of oxygen within an organism or cell." [GOC:rh1] +is_a: GO:0033483 ! gas homeostasis + +[Term] +id: GO:0032365 +name: intracellular lipid transport +namespace: biological_process +def: "The directed movement of lipids within cells." [GOC:mah] +is_a: GO:0006869 ! lipid transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0032366 +name: intracellular sterol transport +namespace: biological_process +def: "The directed movement of sterols within cells." [GOC:mah] +is_a: GO:0015918 ! sterol transport +is_a: GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032367 +name: intracellular cholesterol transport +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah] +is_a: GO:0030301 ! cholesterol transport +is_a: GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032368 +name: regulation of lipid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0006869 ! lipid transport + +[Term] +id: GO:0032369 +name: negative regulation of lipid transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of lipid transport" EXACT [] +synonym: "down-regulation of lipid transport" EXACT [] +synonym: "downregulation of lipid transport" EXACT [] +synonym: "inhibition of lipid transport" NARROW [] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0006869 ! lipid transport + +[Term] +id: GO:0032370 +name: positive regulation of lipid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells." [GOC:mah] +synonym: "activation of lipid transport" NARROW [] +synonym: "stimulation of lipid transport" NARROW [] +synonym: "up regulation of lipid transport" EXACT [] +synonym: "up-regulation of lipid transport" EXACT [] +synonym: "upregulation of lipid transport" EXACT [] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0006869 ! lipid transport + +[Term] +id: GO:0032371 +name: regulation of sterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells." [GOC:mah] +is_a: GO:0032368 ! regulation of lipid transport +relationship: regulates GO:0015918 ! sterol transport + +[Term] +id: GO:0032372 +name: negative regulation of sterol transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of sterol transport" EXACT [] +synonym: "down-regulation of sterol transport" EXACT [] +synonym: "downregulation of sterol transport" EXACT [] +synonym: "inhibition of sterol transport" NARROW [] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032371 ! regulation of sterol transport +relationship: negatively_regulates GO:0015918 ! sterol transport + +[Term] +id: GO:0032373 +name: positive regulation of sterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells." [GOC:mah] +synonym: "activation of sterol transport" NARROW [] +synonym: "stimulation of sterol transport" NARROW [] +synonym: "up regulation of sterol transport" EXACT [] +synonym: "up-regulation of sterol transport" EXACT [] +synonym: "upregulation of sterol transport" EXACT [] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032371 ! regulation of sterol transport +relationship: positively_regulates GO:0015918 ! sterol transport + +[Term] +id: GO:0032374 +name: regulation of cholesterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells." [GOC:mah] +is_a: GO:0032371 ! regulation of sterol transport +relationship: regulates GO:0030301 ! cholesterol transport + +[Term] +id: GO:0032375 +name: negative regulation of cholesterol transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of cholesterol transport" EXACT [] +synonym: "down-regulation of cholesterol transport" EXACT [] +synonym: "downregulation of cholesterol transport" EXACT [] +synonym: "inhibition of cholesterol transport" NARROW [] +is_a: GO:0032372 ! negative regulation of sterol transport +is_a: GO:0032374 ! regulation of cholesterol transport +relationship: negatively_regulates GO:0030301 ! cholesterol transport + +[Term] +id: GO:0032376 +name: positive regulation of cholesterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells." [GOC:mah] +synonym: "activation of cholesterol transport" NARROW [] +synonym: "stimulation of cholesterol transport" NARROW [] +synonym: "up regulation of cholesterol transport" EXACT [] +synonym: "up-regulation of cholesterol transport" EXACT [] +synonym: "upregulation of cholesterol transport" EXACT [] +is_a: GO:0032373 ! positive regulation of sterol transport +is_a: GO:0032374 ! regulation of cholesterol transport +relationship: positively_regulates GO:0030301 ! cholesterol transport + +[Term] +id: GO:0032377 +name: regulation of intracellular lipid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032378 +name: negative regulation of intracellular lipid transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] +synonym: "down regulation of intracellular lipid transport" EXACT [] +synonym: "down-regulation of intracellular lipid transport" EXACT [] +synonym: "downregulation of intracellular lipid transport" EXACT [] +synonym: "inhibition of intracellular lipid transport" NARROW [] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032377 ! regulation of intracellular lipid transport +is_a: GO:0032387 ! negative regulation of intracellular transport +relationship: negatively_regulates GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032379 +name: positive regulation of intracellular lipid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] +synonym: "activation of intracellular lipid transport" NARROW [] +synonym: "stimulation of intracellular lipid transport" NARROW [] +synonym: "up regulation of intracellular lipid transport" EXACT [] +synonym: "up-regulation of intracellular lipid transport" EXACT [] +synonym: "upregulation of intracellular lipid transport" EXACT [] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032377 ! regulation of intracellular lipid transport +is_a: GO:0032388 ! positive regulation of intracellular transport +relationship: positively_regulates GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032380 +name: regulation of intracellular sterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] +is_a: GO:0032371 ! regulation of sterol transport +is_a: GO:0032377 ! regulation of intracellular lipid transport +relationship: regulates GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032381 +name: negative regulation of intracellular sterol transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] +synonym: "down regulation of intracellular sterol transport" EXACT [] +synonym: "down-regulation of intracellular sterol transport" EXACT [] +synonym: "downregulation of intracellular sterol transport" EXACT [] +synonym: "inhibition of intracellular sterol transport" NARROW [] +is_a: GO:0032372 ! negative regulation of sterol transport +is_a: GO:0032378 ! negative regulation of intracellular lipid transport +is_a: GO:0032380 ! regulation of intracellular sterol transport +relationship: negatively_regulates GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032382 +name: positive regulation of intracellular sterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] +synonym: "activation of intracellular sterol transport" NARROW [] +synonym: "stimulation of intracellular sterol transport" NARROW [] +synonym: "up regulation of intracellular sterol transport" EXACT [] +synonym: "up-regulation of intracellular sterol transport" EXACT [] +synonym: "upregulation of intracellular sterol transport" EXACT [] +is_a: GO:0032373 ! positive regulation of sterol transport +is_a: GO:0032379 ! positive regulation of intracellular lipid transport +is_a: GO:0032380 ! regulation of intracellular sterol transport +relationship: positively_regulates GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032383 +name: regulation of intracellular cholesterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] +is_a: GO:0032374 ! regulation of cholesterol transport +is_a: GO:0032380 ! regulation of intracellular sterol transport +relationship: regulates GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0032384 +name: negative regulation of intracellular cholesterol transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] +synonym: "down regulation of intracellular cholesterol transport" EXACT [] +synonym: "down-regulation of intracellular cholesterol transport" EXACT [] +synonym: "downregulation of intracellular cholesterol transport" EXACT [] +synonym: "inhibition of intracellular cholesterol transport" NARROW [] +is_a: GO:0032375 ! negative regulation of cholesterol transport +is_a: GO:0032381 ! negative regulation of intracellular sterol transport +is_a: GO:0032383 ! regulation of intracellular cholesterol transport +relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0032385 +name: positive regulation of intracellular cholesterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] +synonym: "activation of intracellular cholesterol transport" NARROW [] +synonym: "stimulation of intracellular cholesterol transport" NARROW [] +synonym: "up regulation of intracellular cholesterol transport" EXACT [] +synonym: "up-regulation of intracellular cholesterol transport" EXACT [] +synonym: "upregulation of intracellular cholesterol transport" EXACT [] +is_a: GO:0032376 ! positive regulation of cholesterol transport +is_a: GO:0032382 ! positive regulation of intracellular sterol transport +is_a: GO:0032383 ! regulation of intracellular cholesterol transport +relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0032386 +name: regulation of intracellular transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0032387 +name: negative regulation of intracellular transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] +synonym: "down regulation of intracellular transport" EXACT [] +synonym: "down-regulation of intracellular transport" EXACT [] +synonym: "downregulation of intracellular transport" EXACT [] +synonym: "inhibition of intracellular transport" NARROW [] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0032388 +name: positive regulation of intracellular transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] +synonym: "activation of intracellular transport" NARROW [] +synonym: "stimulation of intracellular transport" NARROW [] +synonym: "up regulation of intracellular transport" EXACT [] +synonym: "up-regulation of intracellular transport" EXACT [] +synonym: "upregulation of intracellular transport" EXACT [] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0032389 +name: MutLalpha complex +namespace: cellular_component +def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk] +synonym: "MLH1/PMS2 complex" EXACT [] +synonym: "MMR complex" BROAD [] +is_a: GO:0032300 ! mismatch repair complex + +[Term] +id: GO:0032390 +name: MutLbeta complex +namespace: cellular_component +def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk] +synonym: "MLH1/PMS1 complex" EXACT [] +synonym: "MMR complex" BROAD [] +is_a: GO:0032300 ! mismatch repair complex + +[Term] +id: GO:0032391 +name: photoreceptor connecting cilium +namespace: cellular_component +def: "A 9+0 cilium that forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments." [PMID:15917207, PMID:8718680] +synonym: "photoreceptor cilium" RELATED [] +is_a: GO:0031513 ! nonmotile primary cilium + +[Term] +id: GO:0032392 +name: DNA geometric change +namespace: biological_process +def: "The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah] +comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. +subset: goslim_pir +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0032393 +name: MHC class I receptor activity +namespace: molecular_function +def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0032394 +name: MHC class Ib receptor activity +namespace: molecular_function +def: "Combining with an MHC class Ib protein complex to initiate a change in cellular activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0032395 +name: MHC class II receptor activity +namespace: molecular_function +def: "Combining with an MHC class II protein complex to initiate a change in cellular activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0032396 +name: inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134] +is_a: GO:0032393 ! MHC class I receptor activity + +[Term] +id: GO:0032397 +name: activating MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134] +is_a: GO:0032393 ! MHC class I receptor activity + +[Term] +id: GO:0032398 +name: MHC class Ib protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15928678] +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: GO:0032399 +name: HECT domain binding +namespace: molecular_function +def: "Interacting selectively with a HECT, 'Homologous to the E6-AP Carboxyl Terminus', domain of a protein." [GOC:mah, Pfam:PF00632] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032400 +name: melanosome localization +namespace: biological_process +def: "Any process by which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln] +is_a: GO:0051875 ! pigment granule localization + +[Term] +id: GO:0032401 +name: establishment of melanosome localization +namespace: biological_process +def: "The directed movement of a melanosome to a specific location." [GOC:mah] +is_a: GO:0051905 ! establishment of pigment granule localization +relationship: part_of GO:0032400 ! melanosome localization + +[Term] +id: GO:0032402 +name: melanosome transport +namespace: biological_process +def: "The directed movement of melanosomes into, out of, within or between cells." [GOC:ln] +is_a: GO:0032401 ! establishment of melanosome localization +is_a: GO:0051904 ! pigment granule transport + +[Term] +id: GO:0032403 +name: protein complex binding +namespace: molecular_function +def: "Interacting selectively with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032404 +name: mismatch repair complex binding +namespace: molecular_function +def: "Interacting selectively with a mismatch repair complex." [GOC:vk] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0032405 +name: MutLalpha complex binding +namespace: molecular_function +def: "Interacting selectively with the mismatch repair complex MutLalpha." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032406 +name: MutLbeta complex binding +namespace: molecular_function +def: "Interacting selectively with the mismatch repair complex MutLbeta." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032407 +name: MutSalpha complex binding +namespace: molecular_function +def: "Interacting selectively with the mismatch repair complex MutSalpha." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032408 +name: MutSbeta complex binding +namespace: molecular_function +def: "Interacting selectively with the mismatch repair complex MutSbeta." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032409 +name: regulation of transporter activity +namespace: biological_process +def: "Any process that modulates the activity of a transporter." [GOC:mah] +subset: gosubset_prok +is_a: GO:0051049 ! regulation of transport +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0032410 +name: negative regulation of transporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] +synonym: "down regulation of transporter activity" EXACT [] +synonym: "down-regulation of transporter activity" EXACT [] +synonym: "downregulation of transporter activity" EXACT [] +synonym: "inhibition of transporter activity" NARROW [] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0051051 ! negative regulation of transport + +[Term] +id: GO:0032411 +name: positive regulation of transporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of a transporter." [GOC:mah] +synonym: "activation of transporter activity" NARROW [] +synonym: "stimulation of transporter activity" NARROW [] +synonym: "up regulation of transporter activity" EXACT [] +synonym: "up-regulation of transporter activity" EXACT [] +synonym: "upregulation of transporter activity" EXACT [] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0051050 ! positive regulation of transport + +[Term] +id: GO:0032412 +name: regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] +subset: gosubset_prok +synonym: "regulation of ion transporter activity" EXACT [GOC:tb] +is_a: GO:0022898 ! regulation of transmembrane transporter activity + +[Term] +id: GO:0032413 +name: negative regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "down regulation of ion transporter activity" EXACT [] +synonym: "down-regulation of ion transporter activity" EXACT [] +synonym: "downregulation of ion transporter activity" EXACT [] +synonym: "inhibition of ion transporter activity" NARROW [] +synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0032414 +name: positive regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "activation of ion transporter activity" NARROW [] +synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] +synonym: "stimulation of ion transporter activity" NARROW [] +synonym: "up regulation of ion transporter activity" EXACT [] +synonym: "up-regulation of ion transporter activity" EXACT [] +synonym: "upregulation of ion transporter activity" EXACT [] +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0032415 +name: regulation of sodium:hydrogen antiporter activity +namespace: biological_process +def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0032416 +name: negative regulation of sodium:hydrogen antiporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] +synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW [] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0032415 ! regulation of sodium:hydrogen antiporter activity + +[Term] +id: GO:0032417 +name: positive regulation of sodium:hydrogen antiporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] +synonym: "activation of sodium:hydrogen antiporter activity" NARROW [] +synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW [] +synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT [] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:0032415 ! regulation of sodium:hydrogen antiporter activity + +[Term] +id: GO:0032418 +name: lysosome localization +namespace: biological_process +def: "Any process by which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0032419 +name: extrinsic to lysosome membrane +namespace: cellular_component +def: "Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region." [GOC:mah] +synonym: "extrinsic to lysosomal membrane" EXACT [] +is_a: GO:0000306 ! extrinsic to vacuolar membrane +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0032420 +name: stereocilium +namespace: cellular_component +def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137] +is_a: GO:0005902 ! microvillus +is_a: GO:0044422 ! organelle part +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0032421 ! stereocilium bundle + +[Term] +id: GO:0032421 +name: stereocilium bundle +namespace: cellular_component +def: "An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137] +subset: goslim_pir +synonym: "stereocilia bundle" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0032422 +name: purine-rich negative regulatory element binding +namespace: molecular_function +def: "Interacting selectively with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411] +synonym: "PNR element binding" BROAD [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0032423 +name: regulation of mismatch repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0006298 ! mismatch repair + +[Term] +id: GO:0032424 +name: negative regulation of mismatch repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mismatch repair." [GOC:vk] +synonym: "down regulation of mismatch repair" EXACT [] +synonym: "down-regulation of mismatch repair" EXACT [] +synonym: "downregulation of mismatch repair" EXACT [] +synonym: "inhibition of mismatch repair" NARROW [] +is_a: GO:0032423 ! regulation of mismatch repair +is_a: GO:0045738 ! negative regulation of DNA repair +relationship: negatively_regulates GO:0006298 ! mismatch repair + +[Term] +id: GO:0032425 +name: positive regulation of mismatch repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk] +synonym: "activation of mismatch repair" NARROW [] +synonym: "stimulation of mismatch repair" NARROW [] +synonym: "up regulation of mismatch repair" EXACT [] +synonym: "up-regulation of mismatch repair" EXACT [] +synonym: "upregulation of mismatch repair" EXACT [] +is_a: GO:0032423 ! regulation of mismatch repair +is_a: GO:0045739 ! positive regulation of DNA repair +relationship: positively_regulates GO:0006298 ! mismatch repair + +[Term] +id: GO:0032426 +name: stereocilium bundle tip +namespace: cellular_component +def: "The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface." [GOC:ecd, PMID:17021180] +synonym: "stereocilium tip" RELATED [] +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0032421 ! stereocilium bundle + +[Term] +id: GO:0032427 +name: GBD domain binding +namespace: molecular_function +def: "Interacting selectively with the GBD (GTPase protein binding domain) domain of small GTPases." [GOC:pg] +synonym: "CRIB motif binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032428 +name: beta-N-acetylgalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53] +synonym: "beta-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] +synonym: "beta-D-N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] +synonym: "beta-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.53] +synonym: "N-acetyl-beta-D-galactosaminidase activity" EXACT [EC:3.2.1.53] +synonym: "N-acetyl-beta-galactosaminidase activity" EXACT [EC:3.2.1.53] +synonym: "N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53] +xref: EC:3.2.1.53 +is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity + +[Term] +id: GO:0032429 +name: regulation of phospholipase A2 activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah] +is_a: GO:0010517 ! regulation of phospholipase activity + +[Term] +id: GO:0032430 +name: positive regulation of phospholipase A2 activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah] +synonym: "activation of phospholipase A2 activity" NARROW [] +synonym: "stimulation of phospholipase A2 activity" NARROW [] +synonym: "up regulation of phospholipase A2 activity" EXACT [] +synonym: "up-regulation of phospholipase A2 activity" EXACT [] +synonym: "upregulation of phospholipase A2 activity" EXACT [] +is_a: GO:0010518 ! positive regulation of phospholipase activity +is_a: GO:0032429 ! regulation of phospholipase A2 activity + +[Term] +id: GO:0032431 +name: activation of phospholipase A2 +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah] +synonym: "phospholipase A2 activation" EXACT [] +is_a: GO:0032430 ! positive regulation of phospholipase A2 activity + +[Term] +id: GO:0032432 +name: actin filament bundle +namespace: cellular_component +def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0032433 +name: filopodium tip +namespace: cellular_component +def: "The end of a filopodium distal to the body of the cell." [GOC:mah] +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0030175 ! filopodium + +[Term] +id: GO:0032434 +name: regulation of proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +relationship: regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0032435 +name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] +synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:0045861 ! negative regulation of proteolysis +relationship: negatively_regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0032436 +name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] +synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:0045862 ! positive regulation of proteolysis +relationship: positively_regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0032437 +name: cuticular plate +namespace: cellular_component +def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0032438 +name: melanosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] +synonym: "melanosome organization and biogenesis" EXACT [] +is_a: GO:0048753 ! pigment granule organization + +[Term] +id: GO:0032439 +name: endosome localization +namespace: biological_process +def: "Any process by which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0032440 +name: 2-alkenal reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] +synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74] +synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74] +synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [] +xref: EC:1.3.1.74 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0032441 +name: pheophorbide a oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite (RCC) + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336] +xref: EC:1.8.-.- +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0032442 +name: phenylcoumaran benzylic ether reductase activity +namespace: molecular_function +def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction dehydrodiconiferyl alcohol + NADPH = isodihydrodehydrodiconiferyl alcohol + NADP." [PMID:11030549, PMID:13129921] +synonym: "PCBER activity" EXACT [] +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0032443 +name: regulation of ergosterol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0006696 ! ergosterol biosynthetic process + +[Term] +id: GO:0032444 +name: activin responsive factor complex +namespace: cellular_component +def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] +comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). +synonym: "ARF complex" EXACT [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0032445 +name: fructose import +namespace: biological_process +def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah] +subset: gosubset_prok +synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015755 ! fructose transport + +[Term] +id: GO:0032446 +name: protein modification by small protein conjugation +namespace: biological_process +def: "A process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0032447 +name: protein urmylation +namespace: biological_process +def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw] +is_a: GO:0032446 ! protein modification by small protein conjugation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0032448 +name: DNA hairpin binding +namespace: molecular_function +def: "Interacting selectively with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0032449 +name: CBM complex +namespace: cellular_component +def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454] +synonym: "CARMA1-BCL10-Malt1 complex" EXACT [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0032450 +name: maltase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of maltose by an alpha-D-glucosidase-type action." [GOC:pd] +is_a: GO:0004558 ! alpha-glucosidase activity + +[Term] +id: GO:0032451 +name: demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah] +subset: goslim_pir +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0032452 +name: histone demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah] +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0032453 +name: histone demethylase activity (H3-K4 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah] +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0032454 +name: histone demethylase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from lysine at position 9 of the histone H3 protein." [GOC:mah] +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0032455 +name: nerve growth factor processing +namespace: biological_process +def: "The generation of a mature nerve growth factor by proteolysis of a precursor." [GOC:mah, PMID:8615794] +is_a: GO:0016486 ! peptide hormone processing +is_a: GO:0051605 ! protein maturation via proteolysis + +[Term] +id: GO:0032456 +name: endocytic recycling +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] +synonym: "retrograde transport of endocytic vesicles" RELATED [] +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0032457 +name: fast endocytic recycling +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] +synonym: "direct endocytic recycling" EXACT [] +is_a: GO:0032456 ! endocytic recycling + +[Term] +id: GO:0032458 +name: slow endocytic recycling +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] +is_a: GO:0032456 ! endocytic recycling + +[Term] +id: GO:0032459 +name: regulation of protein oligomerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah] +subset: gosubset_prok +is_a: GO:0043254 ! regulation of protein complex assembly +relationship: regulates GO:0051259 ! protein oligomerization + +[Term] +id: GO:0032460 +name: negative regulation of protein oligomerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of protein oligomerization" EXACT [] +synonym: "down-regulation of protein oligomerization" EXACT [] +synonym: "downregulation of protein oligomerization" EXACT [] +synonym: "inhibition of protein oligomerization" NARROW [] +is_a: GO:0031333 ! negative regulation of protein complex assembly +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: negatively_regulates GO:0051259 ! protein oligomerization + +[Term] +id: GO:0032461 +name: positive regulation of protein oligomerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah] +subset: gosubset_prok +synonym: "activation of protein oligomerization" NARROW [] +synonym: "induction of protein oligomerization" RELATED [] +synonym: "stimulation of protein oligomerization" NARROW [] +synonym: "up regulation of protein oligomerization" EXACT [] +synonym: "up-regulation of protein oligomerization" EXACT [] +synonym: "upregulation of protein oligomerization" EXACT [] +is_a: GO:0031334 ! positive regulation of protein complex assembly +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: positively_regulates GO:0051259 ! protein oligomerization + +[Term] +id: GO:0032462 +name: regulation of protein homooligomerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah] +subset: gosubset_prok +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: regulates GO:0051260 ! protein homooligomerization + +[Term] +id: GO:0032463 +name: negative regulation of protein homooligomerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of protein homooligomerization" EXACT [] +synonym: "down-regulation of protein homooligomerization" EXACT [] +synonym: "downregulation of protein homooligomerization" EXACT [] +synonym: "inhibition of protein homooligomerization" NARROW [] +is_a: GO:0032460 ! negative regulation of protein oligomerization +is_a: GO:0032462 ! regulation of protein homooligomerization +relationship: negatively_regulates GO:0051260 ! protein homooligomerization + +[Term] +id: GO:0032464 +name: positive regulation of protein homooligomerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah] +subset: gosubset_prok +synonym: "activation of protein homooligomerization" NARROW [] +synonym: "induction of protein homooligomerization" RELATED [] +synonym: "stimulation of protein homooligomerization" NARROW [] +synonym: "up regulation of protein homooligomerization" EXACT [] +synonym: "up-regulation of protein homooligomerization" EXACT [] +synonym: "upregulation of protein homooligomerization" EXACT [] +is_a: GO:0032461 ! positive regulation of protein oligomerization +is_a: GO:0032462 ! regulation of protein homooligomerization +relationship: positively_regulates GO:0051260 ! protein homooligomerization + +[Term] +id: GO:0032465 +name: regulation of cytokinesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0000910 ! cytokinesis + +[Term] +id: GO:0032466 +name: negative regulation of cytokinesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis." [GOC:mah] +synonym: "down regulation of cytokinesis" EXACT [] +synonym: "down-regulation of cytokinesis" EXACT [] +synonym: "downregulation of cytokinesis" EXACT [] +synonym: "inhibition of cytokinesis" NARROW [] +is_a: GO:0032465 ! regulation of cytokinesis +is_a: GO:0051782 ! negative regulation of cell division +relationship: negatively_regulates GO:0000910 ! cytokinesis + +[Term] +id: GO:0032467 +name: positive regulation of cytokinesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytokinesis." [GOC:mah] +synonym: "activation of cytokinesis" NARROW [] +synonym: "stimulation of cytokinesis" NARROW [] +synonym: "up regulation of cytokinesis" EXACT [] +synonym: "up-regulation of cytokinesis" EXACT [] +synonym: "upregulation of cytokinesis" EXACT [] +is_a: GO:0032465 ! regulation of cytokinesis +is_a: GO:0051781 ! positive regulation of cell division +relationship: positively_regulates GO:0000910 ! cytokinesis + +[Term] +id: GO:0032468 +name: Golgi calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] +synonym: "calcium ion homeostasis in Golgi" EXACT [] +synonym: "Golgi calcium ion concentration regulation" EXACT [] +synonym: "regulation of calcium ion concentration in Golgi" EXACT [] +synonym: "regulation of Golgi calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0032469 +name: endoplasmic reticulum calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah] +synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT [] +synonym: "calcium ion homeostasis in ER" EXACT [] +synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT [] +synonym: "ER calcium ion concentration regulation" EXACT [] +synonym: "ER calcium ion homeostasis" EXACT [] +synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT [] +synonym: "regulation of calcium ion concentration in ER" EXACT [] +synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "regulation of ER calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0032470 +name: elevation of endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] +synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT [] +synonym: "elevation of ER calcium ion concentration" EXACT [] +synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT [] +is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0032471 +name: reduction of endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] +synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT [] +synonym: "ER calcium ion concentration reduction" EXACT [] +synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT [] +synonym: "reduction of calcium ion concentration in ER" EXACT [] +synonym: "reduction of ER calcium ion concentration" EXACT [] +is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0032472 +name: Golgi calcium ion transport +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah] +synonym: "Golgi calcium transport" EXACT [] +is_a: GO:0006816 ! calcium ion transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0032473 +name: external side of mitochondrial outer membrane +namespace: cellular_component +def: "The external (cytoplasmic face) of the mitochondrial outer membrane." [GOC:mah] +synonym: "cytosolic side of mitochondrial outer membrane" EXACT [] +synonym: "external side of mitochondrial envelope" RELATED [] +is_a: GO:0044455 ! mitochondrial membrane part + +[Term] +id: GO:0032474 +name: otolith morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of an otolith are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0048840 ! otolith development + +[Term] +id: GO:0032475 +name: otolith formation +namespace: biological_process +def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0032474 ! otolith morphogenesis + +[Term] +id: GO:0032476 +name: decaprenyl diphosphate synthase complex +namespace: cellular_component +def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123] +subset: goslim_pir +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0032477 +name: homodimeric decaprenyl diphosphate synthase complex +namespace: cellular_component +def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123] +is_a: GO:0032476 ! decaprenyl diphosphate synthase complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0032478 +name: heterotetrameric decaprenyl diphosphate synthase complex +namespace: cellular_component +def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123] +is_a: GO:0032476 ! decaprenyl diphosphate synthase complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0032479 +name: regulation of type I interferon production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] +synonym: "regulation of type I IFN production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032606 ! type I interferon production + +[Term] +id: GO:0032480 +name: negative regulation of type I interferon production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] +synonym: "down regulation of type I interferon production" EXACT [] +synonym: "down-regulation of type I interferon production" EXACT [] +synonym: "downregulation of type I interferon production" EXACT [] +synonym: "inhibition of type I interferon production" NARROW [] +synonym: "negative regulation of type I IFN production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032479 ! regulation of type I interferon production +relationship: negatively_regulates GO:0032606 ! type I interferon production + +[Term] +id: GO:0032481 +name: positive regulation of type I interferon production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] +synonym: "activation of type I interferon production" NARROW [] +synonym: "stimulation of type I interferon production" NARROW [] +synonym: "up regulation of type I interferon production" EXACT [] +synonym: "up-regulation of type I interferon production" EXACT [] +synonym: "upregulation of type I interferon production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032479 ! regulation of type I interferon production +relationship: positively_regulates GO:0032606 ! type I interferon production + +[Term] +id: GO:0032482 +name: Rab protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032483 +name: regulation of Rab protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032482 ! Rab protein signal transduction + +[Term] +id: GO:0032484 +name: Ral protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032485 +name: regulation of Ral protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032484 ! Ral protein signal transduction + +[Term] +id: GO:0032486 +name: Rap protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032487 +name: regulation of Rap protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032486 ! Rap protein signal transduction + +[Term] +id: GO:0032488 +name: Cdc42 protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0032489 +name: regulation of Cdc42 protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +relationship: regulates GO:0032488 ! Cdc42 protein signal transduction + +[Term] +id: GO:0032490 +name: detection of molecule of bacterial origin +namespace: biological_process +def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl] +synonym: "detection of bacteria associated molecule" EXACT [] +synonym: "detection of bacterial associated molecule" EXACT [] +synonym: "detection of bacterium associated molecule" EXACT [] +is_a: GO:0002237 ! response to molecule of bacterial origin +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0032491 +name: detection of molecule of fungal origin +namespace: biological_process +def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] +synonym: "detection of fungal associated molecule" EXACT [] +synonym: "detection of fungus associated molecule" EXACT [] +is_a: GO:0002238 ! response to molecule of fungal origin +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0032492 +name: detection of molecule of oomycetes origin +namespace: biological_process +def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] +synonym: "detection of oomycetes associated molecule" EXACT [] +is_a: GO:0002240 ! response to molecule of oomycetes origin +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0032493 +name: response to bacterial lipoprotein +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222] +is_a: GO:0002237 ! response to molecule of bacterial origin + +[Term] +id: GO:0032494 +name: response to peptidoglycan +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] +is_a: GO:0002237 ! response to molecule of bacterial origin + +[Term] +id: GO:0032495 +name: response to muramyl dipeptide +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add] +is_a: GO:0032494 ! response to peptidoglycan + +[Term] +id: GO:0032496 +name: response to lipopolysaccharide +namespace: biological_process +def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] +synonym: "response to LPS" EXACT [] +is_a: GO:0002237 ! response to molecule of bacterial origin + +[Term] +id: GO:0032497 +name: detection of lipopolysaccharide +namespace: biological_process +def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797] +synonym: "detection of LPS" EXACT [] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0032496 ! response to lipopolysaccharide + +[Term] +id: GO:0032498 +name: detection of muramyl dipeptide +namespace: biological_process +def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797] +is_a: GO:0032495 ! response to muramyl dipeptide +is_a: GO:0032499 ! detection of peptidoglycan + +[Term] +id: GO:0032499 +name: detection of peptidoglycan +namespace: biological_process +def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0032494 ! response to peptidoglycan + +[Term] +id: GO:0032500 +name: muramyl dipeptide binding +namespace: molecular_function +def: "Interacting selectively, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] +is_a: GO:0042834 ! peptidoglycan binding + +[Term] +id: GO:0032501 +name: multicellular organismal process +namespace: biological_process +alt_id: GO:0050874 +def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] +subset: goslim_goa +subset: goslim_pir +synonym: "organismal physiological process" EXACT [] +is_a: GO:0008150 ! biological_process +disjoint_from: GO:0009987 ! cellular process +disjoint_from: GO:0051704 ! multi-organism process + +[Term] +id: GO:0032502 +name: developmental process +namespace: biological_process +def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] +subset: goslim_pir +subset: gosubset_prok +synonym: "development" NARROW [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0032504 +name: multicellular organism reproduction +namespace: biological_process +def: "The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jic] +is_a: GO:0000003 ! reproduction +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0032505 +name: reproduction of a single-celled organism +namespace: biological_process +def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0000003 ! reproduction +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0032506 +name: cytokinetic process +namespace: biological_process +def: "A cellular process that is involved in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:isa_complete, GOC:mah] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0000910 ! cytokinesis + +[Term] +id: GO:0032507 +name: maintenance of protein location in cell +namespace: biological_process +def: "Any process by which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] +synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] +is_a: GO:0045185 ! maintenance of protein location +is_a: GO:0051651 ! maintenance of location in cell + +[Term] +id: GO:0032508 +name: DNA duplex unwinding +namespace: biological_process +def: "The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] +synonym: "DNA unwinding" EXACT [] +synonym: "duplex DNA melting" EXACT [] +is_a: GO:0032392 ! DNA geometric change + +[Term] +id: GO:0032509 +name: endosome transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] +synonym: "endosome transport via MVB sorting pathway" EXACT [] +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0032510 +name: endosome to lysosome transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637] +synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT [] +is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway +is_a: GO:0045022 ! early endosome to late endosome transport + +[Term] +id: GO:0032511 +name: late endosome to vacuole transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637] +synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT [] +is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway +is_a: GO:0045324 ! late endosome to vacuole transport + +[Term] +id: GO:0032512 +name: regulation of protein phosphatase type 2B activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme protein phosphatase type 2B." [GOC:mah] +synonym: "regulation of calcineurin activity" EXACT [] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0032513 +name: negative regulation of protein phosphatase type 2B activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2B." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of protein phosphatase type 2B activity" EXACT [] +synonym: "down-regulation of protein phosphatase type 2B activity" EXACT [] +synonym: "downregulation of protein phosphatase type 2B activity" EXACT [] +synonym: "inhibition of protein phosphatase type 2B activity" NARROW [] +synonym: "negative regulation of calcineurin activity" EXACT [] +is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity +is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0032514 +name: positive regulation of protein phosphatase type 2B activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2B." [GOC:mah] +subset: gosubset_prok +synonym: "activation of protein phosphatase type 2B activity" NARROW [] +synonym: "calcineurin activation" EXACT [] +synonym: "positive regulation of calcineurin activity" EXACT [] +synonym: "stimulation of protein phosphatase type 2B activity" NARROW [] +synonym: "up regulation of protein phosphatase type 2B activity" EXACT [] +synonym: "up-regulation of protein phosphatase type 2B activity" EXACT [] +synonym: "upregulation of protein phosphatase type 2B activity" EXACT [] +is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity +is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0032515 +name: negative regulation of phosphoprotein phosphatase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "downregulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "inhibition of phosphoprotein phosphatase activity" NARROW [] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity +is_a: GO:0051004 ! regulation of lipoprotein lipase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0032516 +name: positive regulation of phosphoprotein phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah] +subset: gosubset_prok +synonym: "activation of phosphoprotein phosphatase activity" NARROW [] +synonym: "stimulation of phosphoprotein phosphatase activity" NARROW [] +synonym: "up regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "upregulation of phosphoprotein phosphatase activity" EXACT [] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity +is_a: GO:0051004 ! regulation of lipoprotein lipase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0032517 +name: SOD1-calcineurin complex +namespace: cellular_component +def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0032518 +name: amino acid-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) = ADP + phosphate + amino acid(out)." [GOC:mah] +is_a: GO:0015424 ! amino acid-transporting ATPase activity + +[Term] +id: GO:0032519 +name: cysteine-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) = ADP + phosphate + cysteine(out)." [GOC:mah] +synonym: "cysteine exporter" RELATED [] +is_a: GO:0032518 ! amino acid-exporting ATPase activity +is_a: GO:0033230 ! cysteine-transporting ATPase activity + +[Term] +id: GO:0032520 +name: amino acid-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) = ADP + phosphate + amino acid(in)." [GOC:mah] +is_a: GO:0015424 ! amino acid-transporting ATPase activity + +[Term] +id: GO:0032521 +name: D-methionine-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) = ADP + phosphate + D-methionine(out)." [GOC:mah] +synonym: "D-methionine exporter" RELATED [] +is_a: GO:0032518 ! amino acid-exporting ATPase activity +is_a: GO:0033232 ! D-methionine-transporting ATPase activity + +[Term] +id: GO:0032522 +name: D-methionine-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) = ADP + phosphate + D-methionine(in)." [GOC:mah] +synonym: "D-methionine importer" RELATED [] +is_a: GO:0032520 ! amino acid-importing ATPase activity +is_a: GO:0033232 ! D-methionine-transporting ATPase activity + +[Term] +id: GO:0032523 +name: silicon efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566] +synonym: "silicon efflux transporter activity" EXACT [] +is_a: GO:0005351 ! sugar:hydrogen symporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0032524 +name: nutrient export +namespace: biological_process +def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah] +comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. +subset: gosubset_prok +is_obsolete: true +consider: GO:0006810 + +[Term] +id: GO:0032525 +name: somite rostral/caudal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776] +synonym: "somite rostrocaudal axis specification" EXACT [] +synonym: "somite rostrocaudal polarity" RELATED [] +is_a: GO:0009948 ! anterior/posterior axis specification +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0032526 +name: response to retinoic acid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl] +synonym: "response to vitamin A acid" EXACT [] +is_a: GO:0033189 ! response to vitamin A + +[Term] +id: GO:0032527 +name: protein exit from endoplasmic reticulum +namespace: biological_process +def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb] +synonym: "protein exit from ER" EXACT [] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0032528 +name: microvillus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] +synonym: "microvillus organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0032529 +name: follicle cell microvillus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588] +synonym: "follicle cell microvillus organization and biogenesis" EXACT [] +is_a: GO:0032528 ! microvillus organization + +[Term] +id: GO:0032530 +name: regulation of microvillus organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] +synonym: "regulation of microvillus organization and biogenesis" EXACT [] +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0032528 ! microvillus organization + +[Term] +id: GO:0032531 +name: regulation of follicle cell microvillus organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah] +synonym: "regulation of follicle cell microvillus organization and biogenesis" EXACT [] +is_a: GO:0032530 ! regulation of microvillus organization +relationship: regulates GO:0032529 ! follicle cell microvillus organization + +[Term] +id: GO:0032532 +name: regulation of microvillus length +namespace: biological_process +def: "A process that modulates the length of a microvillus." [GOC:mah] +is_a: GO:0032530 ! regulation of microvillus organization +is_a: GO:0032536 ! regulation of cell projection size + +[Term] +id: GO:0032533 +name: regulation of follicle cell microvillus length +namespace: biological_process +def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500] +is_a: GO:0032531 ! regulation of follicle cell microvillus organization +is_a: GO:0032532 ! regulation of microvillus length + +[Term] +id: GO:0032534 +name: regulation of microvillus biogenesis +namespace: biological_process +def: "A process that modulates the formation of a microvillus." [GOC:mah] +is_a: GO:0032530 ! regulation of microvillus organization +relationship: regulates GO:0030033 ! microvillus biogenesis + +[Term] +id: GO:0032535 +name: regulation of cellular component size +namespace: biological_process +def: "A process that modulates the size of a cellular component." [GOC:mah] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0032536 +name: regulation of cell projection size +namespace: biological_process +def: "A process that modulates the size of a cell projection." [GOC:mah] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0032537 +name: host-seeking behavior +namespace: biological_process +def: "The specific actions or reactions of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, PMID:11931033] +synonym: "host-seeking behaviour" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0032538 +name: regulation of host-seeking behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] +synonym: "regulation of host-seeking behaviour" EXACT [] +is_a: GO:0050795 ! regulation of behavior +relationship: part_of GO:0018991 ! oviposition +relationship: regulates GO:0032537 ! host-seeking behavior + +[Term] +id: GO:0032539 +name: negative regulation of host-seeking behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] +synonym: "down regulation of host-seeking behavior" EXACT [] +synonym: "down-regulation of host-seeking behavior" EXACT [] +synonym: "downregulation of host-seeking behavior" EXACT [] +synonym: "inhibition of host-seeking behavior" NARROW [] +synonym: "negative regulation of host-seeking behaviour" EXACT [] +is_a: GO:0032538 ! regulation of host-seeking behavior +is_a: GO:0048521 ! negative regulation of behavior +relationship: negatively_regulates GO:0032537 ! host-seeking behavior + +[Term] +id: GO:0032540 +name: positive regulation of host-seeking behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] +synonym: "activation of host-seeking behavior" NARROW [] +synonym: "positive regulation of host-seeking behaviour" EXACT [] +synonym: "stimulation of host-seeking behavior" NARROW [] +synonym: "up regulation of host-seeking behavior" EXACT [] +synonym: "up-regulation of host-seeking behavior" EXACT [] +synonym: "upregulation of host-seeking behavior" EXACT [] +is_a: GO:0032538 ! regulation of host-seeking behavior +is_a: GO:0048520 ! positive regulation of behavior +relationship: positively_regulates GO:0032537 ! host-seeking behavior + +[Term] +id: GO:0032541 +name: cortical endoplasmic reticulum +namespace: cellular_component +def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782] +synonym: "cortical ER" EXACT [] +synonym: "peripheral endoplasmic reticulum" EXACT [] +synonym: "peripheral ER" EXACT [] +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0032542 +name: sulfiredoxin activity +namespace: molecular_function +def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH <=> peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2] +synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT [] +synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2] +synonym: "Srx1" RELATED [EC:1.8.98.2] +synonym: "sulphiredoxin activity" EXACT [] +xref: EC:1.8.98.2 +xref: MetaCyc:1.8.98.2-RXN +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0032543 +name: mitochondrial translation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "mitochondrial protein anabolism" EXACT [] +synonym: "mitochondrial protein biosynthesis" EXACT [] +synonym: "mitochondrial protein formation" EXACT [] +synonym: "mitochondrial protein synthesis" EXACT [] +synonym: "mitochondrial protein translation" EXACT [] +is_a: GO:0006412 ! translation +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0032544 +name: plastid translation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "plastid protein anabolism" EXACT [] +synonym: "plastid protein biosynthesis" EXACT [] +synonym: "plastid protein formation" EXACT [] +synonym: "plastid protein synthesis" EXACT [] +synonym: "plastid protein translation" EXACT [] +is_a: GO:0006412 ! translation +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0032545 +name: CURI complex +namespace: cellular_component +def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p andIfh1p." [PMID:17452446] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0032546 +name: deoxyribonucleoside binding +namespace: molecular_function +def: "Interacting selectively with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0032547 +name: purine deoxyribonucleoside binding +namespace: molecular_function +def: "Interacting selectively with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001883 ! purine nucleoside binding +is_a: GO:0032546 ! deoxyribonucleoside binding + +[Term] +id: GO:0032548 +name: pyrimidine deoxyribonucleoside binding +namespace: molecular_function +def: "Interacting selectively with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001884 ! pyrimidine nucleoside binding +is_a: GO:0032546 ! deoxyribonucleoside binding + +[Term] +id: GO:0032549 +name: ribonucleoside binding +namespace: molecular_function +def: "Interacting selectively with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0032550 +name: purine ribonucleoside binding +namespace: molecular_function +def: "Interacting selectively with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001883 ! purine nucleoside binding +is_a: GO:0032549 ! ribonucleoside binding + +[Term] +id: GO:0032551 +name: pyrimidine ribonucleoside binding +namespace: molecular_function +def: "Interacting selectively with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001884 ! pyrimidine nucleoside binding +is_a: GO:0032549 ! ribonucleoside binding + +[Term] +id: GO:0032552 +name: deoxyribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0032553 +name: ribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0032554 +name: purine deoxyribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0017076 ! purine nucleotide binding +is_a: GO:0032552 ! deoxyribonucleotide binding + +[Term] +id: GO:0032555 +name: purine ribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0017076 ! purine nucleotide binding +is_a: GO:0032553 ! ribonucleotide binding + +[Term] +id: GO:0032556 +name: pyrimidine deoxyribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019103 ! pyrimidine nucleotide binding +is_a: GO:0032552 ! deoxyribonucleotide binding + +[Term] +id: GO:0032557 +name: pyrimidine ribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019103 ! pyrimidine nucleotide binding +is_a: GO:0032553 ! ribonucleotide binding + +[Term] +id: GO:0032558 +name: adenyl deoxyribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030554 ! adenyl nucleotide binding +is_a: GO:0032554 ! purine deoxyribonucleotide binding + +[Term] +id: GO:0032559 +name: adenyl ribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030554 ! adenyl nucleotide binding +is_a: GO:0032555 ! purine ribonucleotide binding + +[Term] +id: GO:0032560 +name: guanyl deoxyribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019001 ! guanyl nucleotide binding +is_a: GO:0032554 ! purine deoxyribonucleotide binding + +[Term] +id: GO:0032561 +name: guanyl ribonucleotide binding +namespace: molecular_function +def: "Interacting selectively with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019001 ! guanyl nucleotide binding +is_a: GO:0032555 ! purine ribonucleotide binding + +[Term] +id: GO:0032562 +name: dAMP binding +namespace: molecular_function +def: "Interacting selectively with dAMP, deoxyadenosine monophosphate." [GOC:mah] +is_a: GO:0032558 ! adenyl deoxyribonucleotide binding + +[Term] +id: GO:0032563 +name: dADP binding +namespace: molecular_function +def: "Interacting selectively with dADP, deoxyadenosine diphosphate." [GOC:mah] +is_a: GO:0032558 ! adenyl deoxyribonucleotide binding + +[Term] +id: GO:0032564 +name: dATP binding +namespace: molecular_function +def: "Interacting selectively with dATP, deoxyadenosine triphosphate." [GOC:mah] +is_a: GO:0032558 ! adenyl deoxyribonucleotide binding + +[Term] +id: GO:0032565 +name: dGMP binding +namespace: molecular_function +def: "Interacting selectively with dGMP, deoxyguanosine monophosphate." [GOC:mah] +is_a: GO:0032560 ! guanyl deoxyribonucleotide binding + +[Term] +id: GO:0032566 +name: dGDP binding +namespace: molecular_function +def: "Interacting selectively with dGDP, deoxyguanosine diphosphate." [GOC:mah] +is_a: GO:0032560 ! guanyl deoxyribonucleotide binding + +[Term] +id: GO:0032567 +name: dGTP binding +namespace: molecular_function +def: "Interacting selectively with dGTP, deoxyguanosine triphosphate." [GOC:mah] +is_a: GO:0032560 ! guanyl deoxyribonucleotide binding + +[Term] +id: GO:0032568 +name: general transcription from RNA polymerase II promoter +namespace: biological_process +def: "The basal, non-specifically regulated synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Mediated by core RNA polymerase II and a set of general transcription factors; in Saccharomyces five transcription factors are necessary and sufficient for such basal transcription." [GOC:mah] +is_a: GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0032569 +name: specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "The specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. In addition to RNA polymerase II and the general transcription factors, specific transcription requires one or more specific factors that bind to specific DNA sequences or interact with the general transcription machinery." [GOC:mah] +is_a: GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0032570 +name: response to progesterone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] +is_a: GO:0048545 ! response to steroid hormone stimulus + +[Term] +id: GO:0032571 +name: response to vitamin K +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0032572 +name: response to menaquinone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl] +synonym: "response to menatetrenone" EXACT [] +synonym: "response to vitamin K2" EXACT [] +is_a: GO:0032571 ! response to vitamin K + +[Term] +id: GO:0032573 +name: response to phylloquinone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl] +synonym: "response to vitamin K1" EXACT [] +is_a: GO:0032571 ! response to vitamin K + +[Term] +id: GO:0032574 +name: 5'-3' RNA helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] +synonym: "5' to 3' RNA helicase activity" EXACT [] +is_a: GO:0003724 ! RNA helicase activity + +[Term] +id: GO:0032575 +name: ATP-dependent 5'-3' RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] +synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] +is_a: GO:0004004 ! ATP-dependent RNA helicase activity +is_a: GO:0032574 ! 5'-3' RNA helicase activity + +[Term] +id: GO:0032576 +name: O-linoleoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0032577 +name: phosphatidylcholine:cardiolipin O-linoleoyltransferase +namespace: molecular_function +def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] +synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT [] +is_a: GO:0032576 ! O-linoleoyltransferase activity + +[Term] +id: GO:0032578 +name: aleurone grain membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0033095 ! aleurone grain + +[Term] +id: GO:0032579 +name: apical lamina of hyaline layer +namespace: cellular_component +def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0033166 ! hyaline layer + +[Term] +id: GO:0032580 +name: Golgi cisterna membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] +synonym: "Golgi stack membrane" EXACT [] +is_a: GO:0000139 ! Golgi membrane +relationship: part_of GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0032581 +name: ER-dependent peroxisome biogenesis +namespace: biological_process +def: "The de novo formation of peroxisomes from the endoplasmic reticulum." [PMID:16717127, PMID:17646399] +synonym: "endoplasmic reticulum-dependent peroxisome biogenesis" EXACT [] +is_a: GO:0007031 ! peroxisome organization + +[Term] +id: GO:0032582 +name: negative regulation of gene-specific transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the DNA-dependent transcription of a specific gene or genes." [GOC:mah] +synonym: "down regulation of gene-specific transcription" EXACT [] +synonym: "down-regulation of gene-specific transcription" EXACT [] +synonym: "downregulation of gene-specific transcription" EXACT [] +synonym: "inhibition of gene-specific transcription" NARROW [] +is_a: GO:0032583 ! regulation of gene-specific transcription +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent + +[Term] +id: GO:0032583 +name: regulation of gene-specific transcription +namespace: biological_process +def: "Any process that modulates the DNA-dependent transcription of a specific gene or genes." [GOC:mah] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent + +[Term] +id: GO:0032584 +name: growth cone membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0030426 ! growth cone + +[Term] +id: GO:0032585 +name: multivesicular body membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah] +synonym: "multivesicular endosome membrane" EXACT [] +synonym: "MVB membrane" EXACT [] +synonym: "MVE membrane" EXACT [] +is_a: GO:0031902 ! late endosome membrane +relationship: part_of GO:0005771 ! multivesicular body + +[Term] +id: GO:0032586 +name: protein storage vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah] +is_a: GO:0009705 ! plant-type vacuole membrane + +[Term] +id: GO:0032587 +name: ruffle membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] +synonym: "membrane ruffle" RELATED [] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031256 ! leading edge membrane +relationship: part_of GO:0001726 ! ruffle + +[Term] +id: GO:0032588 +name: trans-Golgi network membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah] +synonym: "Golgi trans face membrane" RELATED [] +synonym: "trans Golgi network membrane" EXACT [] +is_a: GO:0000139 ! Golgi membrane +relationship: part_of GO:0005802 ! trans-Golgi network + +[Term] +id: GO:0032589 +name: neuron projection membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031256 ! leading edge membrane +relationship: part_of GO:0043005 ! neuron projection + +[Term] +id: GO:0032590 +name: dendrite membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] +is_a: GO:0032589 ! neuron projection membrane + +[Term] +id: GO:0032591 +name: dendritic spine membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah] +is_a: GO:0032589 ! neuron projection membrane +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0032592 +name: integral to mitochondrial membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] +is_a: GO:0031301 ! integral to organelle membrane + +[Term] +id: GO:0032593 +name: insulin-responsive compartment +namespace: cellular_component +def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329] +synonym: "GLUT4 storage compartment" EXACT [] +synonym: "GSC" RELATED [] +synonym: "IRC" RELATED [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0032594 +name: protein transport within lipid bilayer +namespace: biological_process +def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] +synonym: "protein translocation within membrane" EXACT [] +synonym: "receptor translocation within membrane" NARROW [] +synonym: "receptor transport within lipid bilayer" NARROW [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0032595 +name: B cell receptor transport within lipid bilayer +namespace: biological_process +def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah] +synonym: "B cell receptor translocation within membrane" EXACT [] +synonym: "BCR translocation within membrane" EXACT [] +synonym: "BCR transport within lipid bilayer" EXACT [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0032596 +name: protein transport into membrane raft +namespace: biological_process +def: "The directed movement of a protein into a membrane raft." [GOC:mah] +synonym: "protein translocation into membrane raft" EXACT [] +synonym: "protein transport into lipid raft" EXACT [] +synonym: "receptor translocation into membrane raft" NARROW [] +synonym: "receptor transport into membrane raft" NARROW [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0032597 +name: B cell receptor transport into membrane raft +namespace: biological_process +def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah] +synonym: "B cell receptor translocation into membrane raft" EXACT [] +synonym: "B cell receptor transport into lipid raft" EXACT [] +synonym: "BCR translocation into membrane raft" EXACT [] +synonym: "BCR transport into membrane raft" EXACT [] +is_a: GO:0032595 ! B cell receptor transport within lipid bilayer +is_a: GO:0032596 ! protein transport into membrane raft + +[Term] +id: GO:0032598 +name: B cell receptor transport into immunological synapse +namespace: biological_process +def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah] +synonym: "B cell receptor translocation into immunological synapse" EXACT [] +synonym: "BCR translocation into immunological synapse" EXACT [] +synonym: "BCR transport into immunological synapse" EXACT [] +is_a: GO:0032597 ! B cell receptor transport into membrane raft + +[Term] +id: GO:0032599 +name: protein transport out of membrane raft +namespace: biological_process +def: "The directed movement of a protein out of a membrane raft." [GOC:mah] +synonym: "protein translocation out of membrane raft" EXACT [] +synonym: "protein transport out of lipid raft" EXACT [] +synonym: "receptor translocation out of membrane raft" NARROW [] +synonym: "receptor transport out of membrane raft" NARROW [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0032600 +name: chemokine receptor transport out of membrane raft +namespace: biological_process +def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah] +synonym: "chemokine receptor translocation out of membrane raft" EXACT [] +synonym: "chemokine receptor transport out of lipid raft" EXACT [] +is_a: GO:0032599 ! protein transport out of membrane raft +is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer + +[Term] +id: GO:0032601 +name: connective tissue growth factor production +namespace: biological_process +def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "CCN2 production" EXACT [] +synonym: "CTGF production" EXACT [] +synonym: "Fisp12 production" EXACT [] +synonym: "Hcs24 production" EXACT [] +synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "IGFBP8 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032602 +name: chemokine production +namespace: biological_process +def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032603 +name: fractalkine production +namespace: biological_process +def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0032604 +name: granulocyte macrophage colony-stimulating factor production +namespace: biological_process +def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032605 +name: hepatocyte growth factor production +namespace: biological_process +def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032606 +name: type I interferon production +namespace: biological_process +def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "interferon type I production" EXACT [] +synonym: "type I IFN production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032607 +name: interferon-alpha production +namespace: biological_process +def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0032608 +name: interferon-beta production +namespace: biological_process +def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0032609 +name: interferon-gamma production +namespace: biological_process +def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +synonym: "type II interferon production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032610 +name: interleukin-1 alpha production +namespace: biological_process +def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-1 alpha production" EXACT [] +is_a: GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032611 +name: interleukin-1 beta production +namespace: biological_process +def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-1 beta production" EXACT [] +is_a: GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032612 +name: interleukin-1 production +namespace: biological_process +def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-1 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032613 +name: interleukin-10 production +namespace: biological_process +def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-10 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032614 +name: interleukin-11 production +namespace: biological_process +def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-11 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032615 +name: interleukin-12 production +namespace: biological_process +def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-12 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032616 +name: interleukin-13 production +namespace: biological_process +def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-13 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032617 +name: interleukin-14 production +namespace: biological_process +def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-14 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032618 +name: interleukin-15 production +namespace: biological_process +def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-15 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032619 +name: interleukin-16 production +namespace: biological_process +def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-16 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032620 +name: interleukin-17 production +namespace: biological_process +def: "The appearance of interleukin-17 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-17 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032621 +name: interleukin-18 production +namespace: biological_process +def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-18 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032622 +name: interleukin-19 production +namespace: biological_process +def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-19 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032623 +name: interleukin-2 production +namespace: biological_process +def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-2 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032624 +name: interleukin-20 production +namespace: biological_process +def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-20 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032625 +name: interleukin-21 production +namespace: biological_process +def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-21 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032626 +name: interleukin-22 production +namespace: biological_process +def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-22 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032627 +name: interleukin-23 production +namespace: biological_process +def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-23 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032628 +name: interleukin-24 production +namespace: biological_process +def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-24 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032629 +name: interleukin-25 production +namespace: biological_process +def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-25 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032630 +name: interleukin-26 production +namespace: biological_process +def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-26 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032631 +name: interleukin-27 production +namespace: biological_process +def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-27 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032632 +name: interleukin-3 production +namespace: biological_process +def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-3 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032633 +name: interleukin-4 production +namespace: biological_process +def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-4 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032634 +name: interleukin-5 production +namespace: biological_process +def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-5 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032635 +name: interleukin-6 production +namespace: biological_process +def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-6 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032636 +name: interleukin-7 production +namespace: biological_process +def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-7 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032637 +name: interleukin-8 production +namespace: biological_process +def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-8 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032638 +name: interleukin-9 production +namespace: biological_process +def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "IL-9 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032639 +name: TRAIL production +namespace: biological_process +def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032640 +name: tumor necrosis factor production +namespace: biological_process +def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "TNF production" EXACT [] +synonym: "TNF-alpha production" EXACT [] +synonym: "tumor necrosis factor-alpha production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032641 +name: lymphotoxin A production +namespace: biological_process +def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "LTA production" EXACT [] +synonym: "lymphotoxin-alpha production" EXACT [] +synonym: "TNF-beta production" EXACT [] +synonym: "tumor necrosis factor-beta production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032642 +name: regulation of chemokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032602 ! chemokine production + +[Term] +id: GO:0032643 +name: regulation of connective tissue growth factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] +synonym: "regulation of CCN2 production" EXACT [] +synonym: "regulation of CTGF production" EXACT [] +synonym: "regulation of Fisp12 production" EXACT [] +synonym: "regulation of Hcs24 production" EXACT [] +synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "regulation of IGFBP8 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0032644 +name: regulation of fractalkine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0032603 ! fractalkine production + +[Term] +id: GO:0032645 +name: regulation of granulocyte macrophage colony-stimulating factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0032646 +name: regulation of hepatocyte growth factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0032647 +name: regulation of interferon-alpha production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah] +is_a: GO:0032479 ! regulation of type I interferon production +relationship: regulates GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0032648 +name: regulation of interferon-beta production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah] +is_a: GO:0032479 ! regulation of type I interferon production +relationship: regulates GO:0032608 ! interferon-beta production + +[Term] +id: GO:0032649 +name: regulation of interferon-gamma production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +synonym: "regulation of type II interferon production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0032650 +name: regulation of interleukin-1 alpha production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] +synonym: "regulation of IL-1 alpha production" EXACT [] +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: regulates GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0032651 +name: regulation of interleukin-1 beta production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] +synonym: "regulation of IL-1 beta production" EXACT [] +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: regulates GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0032652 +name: regulation of interleukin-1 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] +synonym: "regulation of IL-1 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032653 +name: regulation of interleukin-10 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] +synonym: "regulation of IL-10 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0032654 +name: regulation of interleukin-11 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah] +synonym: "regulation of IL-11 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0032655 +name: regulation of interleukin-12 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "regulation of IL-12 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0032656 +name: regulation of interleukin-13 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] +synonym: "regulation of IL-13 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0032657 +name: regulation of interleukin-14 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah] +synonym: "regulation of IL-14 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032617 ! interleukin-14 production + +[Term] +id: GO:0032658 +name: regulation of interleukin-15 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah] +synonym: "regulation of IL-15 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0032659 +name: regulation of interleukin-16 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah] +synonym: "regulation of IL-16 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0032660 +name: regulation of interleukin-17 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-17 production." [GOC:mah] +synonym: "regulation of IL-17 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0032661 +name: regulation of interleukin-18 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah] +synonym: "regulation of IL-18 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0032662 +name: regulation of interleukin-19 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah] +synonym: "regulation of IL-19 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0032663 +name: regulation of interleukin-2 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] +synonym: "regulation of IL-2 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0032664 +name: regulation of interleukin-20 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah] +synonym: "regulation of IL-20 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0032665 +name: regulation of interleukin-21 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah] +synonym: "regulation of IL-21 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0032666 +name: regulation of interleukin-22 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] +synonym: "regulation of IL-22 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0032667 +name: regulation of interleukin-23 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "regulation of IL-23 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0032668 +name: regulation of interleukin-24 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah] +synonym: "regulation of IL-24 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0032669 +name: regulation of interleukin-25 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah] +synonym: "regulation of IL-25 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0032670 +name: regulation of interleukin-26 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah] +synonym: "regulation of IL-26 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0032671 +name: regulation of interleukin-27 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah] +synonym: "regulation of IL-27 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0032672 +name: regulation of interleukin-3 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah] +synonym: "regulation of IL-3 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0032673 +name: regulation of interleukin-4 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah] +synonym: "regulation of IL-4 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0032674 +name: regulation of interleukin-5 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] +synonym: "regulation of IL-5 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0032675 +name: regulation of interleukin-6 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] +synonym: "regulation of IL-6 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0032676 +name: regulation of interleukin-7 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah] +synonym: "regulation of IL-7 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0032677 +name: regulation of interleukin-8 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] +synonym: "regulation of IL-8 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0032678 +name: regulation of interleukin-9 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] +synonym: "regulation of IL-9 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0032679 +name: regulation of TRAIL production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032639 ! TRAIL production + +[Term] +id: GO:0032680 +name: regulation of tumor necrosis factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "regulation of TNF production" EXACT [] +synonym: "regulation of TNF-alpha production" EXACT [] +synonym: "regulation of tumor necrosis factor-alpha production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0032681 +name: regulation of lymphotoxin A production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] +synonym: "regulation of LTA production" EXACT [] +synonym: "regulation of lymphotoxin-alpha production" EXACT [] +synonym: "regulation of TNF-beta production" EXACT [] +synonym: "regulation of tumor necrosis factor-beta production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0032682 +name: negative regulation of chemokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah] +synonym: "down regulation of chemokine production" EXACT [] +synonym: "down-regulation of chemokine production" EXACT [] +synonym: "downregulation of chemokine production" EXACT [] +synonym: "inhibition of chemokine production" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032642 ! regulation of chemokine production +relationship: negatively_regulates GO:0032602 ! chemokine production + +[Term] +id: GO:0032683 +name: negative regulation of connective tissue growth factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] +synonym: "down regulation of connective tissue growth factor production" EXACT [] +synonym: "down-regulation of connective tissue growth factor production" EXACT [] +synonym: "downregulation of connective tissue growth factor production" EXACT [] +synonym: "inhibition of connective tissue growth factor production" NARROW [] +synonym: "negative regulation of CCN2 production" EXACT [] +synonym: "negative regulation of CTGF production" EXACT [] +synonym: "negative regulation of Fisp12 production" EXACT [] +synonym: "negative regulation of Hcs24 production" EXACT [] +synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "negative regulation of IGFBP8 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032643 ! regulation of connective tissue growth factor production +relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0032684 +name: negative regulation of fractalkine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah] +synonym: "down regulation of fractalkine production" EXACT [] +synonym: "down-regulation of fractalkine production" EXACT [] +synonym: "downregulation of fractalkine production" EXACT [] +synonym: "inhibition of fractalkine production" NARROW [] +is_a: GO:0032644 ! regulation of fractalkine production +is_a: GO:0032682 ! negative regulation of chemokine production +relationship: negatively_regulates GO:0032603 ! fractalkine production + +[Term] +id: GO:0032685 +name: negative regulation of granulocyte macrophage colony-stimulating factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] +synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production +relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0032686 +name: negative regulation of hepatocyte growth factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] +synonym: "down regulation of hepatocyte growth factor production" EXACT [] +synonym: "down-regulation of hepatocyte growth factor production" EXACT [] +synonym: "downregulation of hepatocyte growth factor production" EXACT [] +synonym: "inhibition of hepatocyte growth factor production" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032646 ! regulation of hepatocyte growth factor production +relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0032687 +name: negative regulation of interferon-alpha production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah] +synonym: "down regulation of interferon-alpha production" EXACT [] +synonym: "down-regulation of interferon-alpha production" EXACT [] +synonym: "downregulation of interferon-alpha production" EXACT [] +synonym: "inhibition of interferon-alpha production" NARROW [] +is_a: GO:0032480 ! negative regulation of type I interferon production +is_a: GO:0032647 ! regulation of interferon-alpha production +relationship: negatively_regulates GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0032688 +name: negative regulation of interferon-beta production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah] +synonym: "down regulation of interferon-beta production" EXACT [] +synonym: "down-regulation of interferon-beta production" EXACT [] +synonym: "downregulation of interferon-beta production" EXACT [] +synonym: "inhibition of interferon-beta production" NARROW [] +is_a: GO:0032480 ! negative regulation of type I interferon production +is_a: GO:0032648 ! regulation of interferon-beta production +relationship: negatively_regulates GO:0032608 ! interferon-beta production + +[Term] +id: GO:0032689 +name: negative regulation of interferon-gamma production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +synonym: "down regulation of interferon-gamma production" EXACT [] +synonym: "down-regulation of interferon-gamma production" EXACT [] +synonym: "downregulation of interferon-gamma production" EXACT [] +synonym: "inhibition of interferon-gamma production" NARROW [] +synonym: "negative regulation of type II interferon production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032649 ! regulation of interferon-gamma production +relationship: negatively_regulates GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0032690 +name: negative regulation of interleukin-1 alpha production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] +synonym: "down regulation of interleukin-1 alpha production" EXACT [] +synonym: "down-regulation of interleukin-1 alpha production" EXACT [] +synonym: "downregulation of interleukin-1 alpha production" EXACT [] +synonym: "inhibition of interleukin-1 alpha production" NARROW [] +synonym: "negative regulation of IL-1 alpha production" EXACT [] +is_a: GO:0032650 ! regulation of interleukin-1 alpha production +is_a: GO:0032692 ! negative regulation of interleukin-1 production +relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0032691 +name: negative regulation of interleukin-1 beta production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] +synonym: "down regulation of interleukin-1 beta production" EXACT [] +synonym: "down-regulation of interleukin-1 beta production" EXACT [] +synonym: "downregulation of interleukin-1 beta production" EXACT [] +synonym: "inhibition of interleukin-1 beta production" NARROW [] +synonym: "negative regulation of IL-1 beta production" EXACT [] +is_a: GO:0032651 ! regulation of interleukin-1 beta production +is_a: GO:0032692 ! negative regulation of interleukin-1 production +relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0032692 +name: negative regulation of interleukin-1 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] +synonym: "down regulation of interleukin-1 production" EXACT [] +synonym: "down-regulation of interleukin-1 production" EXACT [] +synonym: "downregulation of interleukin-1 production" EXACT [] +synonym: "inhibition of interleukin-1 production" NARROW [] +synonym: "negative regulation of IL-1 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: negatively_regulates GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032693 +name: negative regulation of interleukin-10 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] +synonym: "down regulation of interleukin-10 production" EXACT [] +synonym: "down-regulation of interleukin-10 production" EXACT [] +synonym: "downregulation of interleukin-10 production" EXACT [] +synonym: "inhibition of interleukin-10 production" NARROW [] +synonym: "negative regulation of IL-10 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032653 ! regulation of interleukin-10 production +relationship: negatively_regulates GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0032694 +name: negative regulation of interleukin-11 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah] +synonym: "down regulation of interleukin-11 production" EXACT [] +synonym: "down-regulation of interleukin-11 production" EXACT [] +synonym: "downregulation of interleukin-11 production" EXACT [] +synonym: "inhibition of interleukin-11 production" NARROW [] +synonym: "negative regulation of IL-11 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032654 ! regulation of interleukin-11 production +relationship: negatively_regulates GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0032695 +name: negative regulation of interleukin-12 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "down regulation of interleukin-12 production" EXACT [] +synonym: "down-regulation of interleukin-12 production" EXACT [] +synonym: "downregulation of interleukin-12 production" EXACT [] +synonym: "inhibition of interleukin-12 production" NARROW [] +synonym: "negative regulation of IL-12 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032655 ! regulation of interleukin-12 production +relationship: negatively_regulates GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0032696 +name: negative regulation of interleukin-13 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] +synonym: "down regulation of interleukin-13 production" EXACT [] +synonym: "down-regulation of interleukin-13 production" EXACT [] +synonym: "downregulation of interleukin-13 production" EXACT [] +synonym: "inhibition of interleukin-13 production" NARROW [] +synonym: "negative regulation of IL-13 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032656 ! regulation of interleukin-13 production +relationship: negatively_regulates GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0032697 +name: negative regulation of interleukin-14 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah] +synonym: "down regulation of interleukin-14 production" EXACT [] +synonym: "down-regulation of interleukin-14 production" EXACT [] +synonym: "downregulation of interleukin-14 production" EXACT [] +synonym: "inhibition of interleukin-14 production" NARROW [] +synonym: "negative regulation of IL-14 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032657 ! regulation of interleukin-14 production +relationship: negatively_regulates GO:0032617 ! interleukin-14 production + +[Term] +id: GO:0032698 +name: negative regulation of interleukin-15 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah] +synonym: "down regulation of interleukin-15 production" EXACT [] +synonym: "down-regulation of interleukin-15 production" EXACT [] +synonym: "downregulation of interleukin-15 production" EXACT [] +synonym: "inhibition of interleukin-15 production" NARROW [] +synonym: "negative regulation of IL-15 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032658 ! regulation of interleukin-15 production +relationship: negatively_regulates GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0032699 +name: negative regulation of interleukin-16 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah] +synonym: "down regulation of interleukin-16 production" EXACT [] +synonym: "down-regulation of interleukin-16 production" EXACT [] +synonym: "downregulation of interleukin-16 production" EXACT [] +synonym: "inhibition of interleukin-16 production" NARROW [] +synonym: "negative regulation of IL-16 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032659 ! regulation of interleukin-16 production +relationship: negatively_regulates GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0032700 +name: negative regulation of interleukin-17 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-17 production." [GOC:mah] +synonym: "down regulation of interleukin-17 production" EXACT [] +synonym: "down-regulation of interleukin-17 production" EXACT [] +synonym: "downregulation of interleukin-17 production" EXACT [] +synonym: "inhibition of interleukin-17 production" NARROW [] +synonym: "negative regulation of IL-17 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032660 ! regulation of interleukin-17 production +relationship: negatively_regulates GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0032701 +name: negative regulation of interleukin-18 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah] +synonym: "down regulation of interleukin-18 production" EXACT [] +synonym: "down-regulation of interleukin-18 production" EXACT [] +synonym: "downregulation of interleukin-18 production" EXACT [] +synonym: "inhibition of interleukin-18 production" NARROW [] +synonym: "negative regulation of IL-18 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032661 ! regulation of interleukin-18 production +relationship: negatively_regulates GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0032702 +name: negative regulation of interleukin-19 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah] +synonym: "down regulation of interleukin-19 production" EXACT [] +synonym: "down-regulation of interleukin-19 production" EXACT [] +synonym: "downregulation of interleukin-19 production" EXACT [] +synonym: "inhibition of interleukin-19 production" NARROW [] +synonym: "negative regulation of IL-19 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032662 ! regulation of interleukin-19 production +relationship: negatively_regulates GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0032703 +name: negative regulation of interleukin-2 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] +synonym: "down regulation of interleukin-2 production" EXACT [] +synonym: "down-regulation of interleukin-2 production" EXACT [] +synonym: "downregulation of interleukin-2 production" EXACT [] +synonym: "inhibition of interleukin-2 production" NARROW [] +synonym: "negative regulation of IL-2 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032663 ! regulation of interleukin-2 production +relationship: negatively_regulates GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0032704 +name: negative regulation of interleukin-20 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah] +synonym: "down regulation of interleukin-20 production" EXACT [] +synonym: "down-regulation of interleukin-20 production" EXACT [] +synonym: "downregulation of interleukin-20 production" EXACT [] +synonym: "inhibition of interleukin-20 production" NARROW [] +synonym: "negative regulation of IL-20 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032664 ! regulation of interleukin-20 production +relationship: negatively_regulates GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0032705 +name: negative regulation of interleukin-21 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah] +synonym: "down regulation of interleukin-21 production" EXACT [] +synonym: "down-regulation of interleukin-21 production" EXACT [] +synonym: "downregulation of interleukin-21 production" EXACT [] +synonym: "inhibition of interleukin-21 production" NARROW [] +synonym: "negative regulation of IL-21 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032665 ! regulation of interleukin-21 production +relationship: negatively_regulates GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0032706 +name: negative regulation of interleukin-22 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] +synonym: "down regulation of interleukin-22 production" EXACT [] +synonym: "down-regulation of interleukin-22 production" EXACT [] +synonym: "downregulation of interleukin-22 production" EXACT [] +synonym: "inhibition of interleukin-22 production" NARROW [] +synonym: "negative regulation of IL-22 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032666 ! regulation of interleukin-22 production +relationship: negatively_regulates GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0032707 +name: negative regulation of interleukin-23 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "down regulation of interleukin-23 production" EXACT [] +synonym: "down-regulation of interleukin-23 production" EXACT [] +synonym: "downregulation of interleukin-23 production" EXACT [] +synonym: "inhibition of interleukin-23 production" NARROW [] +synonym: "negative regulation of IL-23 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032667 ! regulation of interleukin-23 production +relationship: negatively_regulates GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0032708 +name: negative regulation of interleukin-24 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah] +synonym: "down regulation of interleukin-24 production" EXACT [] +synonym: "down-regulation of interleukin-24 production" EXACT [] +synonym: "downregulation of interleukin-24 production" EXACT [] +synonym: "inhibition of interleukin-24 production" NARROW [] +synonym: "negative regulation of IL-24 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032668 ! regulation of interleukin-24 production +relationship: negatively_regulates GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0032709 +name: negative regulation of interleukin-25 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah] +synonym: "down regulation of interleukin-25 production" EXACT [] +synonym: "down-regulation of interleukin-25 production" EXACT [] +synonym: "downregulation of interleukin-25 production" EXACT [] +synonym: "inhibition of interleukin-25 production" NARROW [] +synonym: "negative regulation of IL-25 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032669 ! regulation of interleukin-25 production +relationship: negatively_regulates GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0032710 +name: negative regulation of interleukin-26 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah] +synonym: "down regulation of interleukin-26 production" EXACT [] +synonym: "down-regulation of interleukin-26 production" EXACT [] +synonym: "downregulation of interleukin-26 production" EXACT [] +synonym: "inhibition of interleukin-26 production" NARROW [] +synonym: "negative regulation of IL-26 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032670 ! regulation of interleukin-26 production +relationship: negatively_regulates GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0032711 +name: negative regulation of interleukin-27 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah] +synonym: "down regulation of interleukin-27 production" EXACT [] +synonym: "down-regulation of interleukin-27 production" EXACT [] +synonym: "downregulation of interleukin-27 production" EXACT [] +synonym: "inhibition of interleukin-27 production" NARROW [] +synonym: "negative regulation of IL-27 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032671 ! regulation of interleukin-27 production +relationship: negatively_regulates GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0032712 +name: negative regulation of interleukin-3 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah] +synonym: "down regulation of interleukin-3 production" EXACT [] +synonym: "down-regulation of interleukin-3 production" EXACT [] +synonym: "downregulation of interleukin-3 production" EXACT [] +synonym: "inhibition of interleukin-3 production" NARROW [] +synonym: "negative regulation of IL-3 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032672 ! regulation of interleukin-3 production +relationship: negatively_regulates GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0032713 +name: negative regulation of interleukin-4 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah] +synonym: "down regulation of interleukin-4 production" EXACT [] +synonym: "down-regulation of interleukin-4 production" EXACT [] +synonym: "downregulation of interleukin-4 production" EXACT [] +synonym: "inhibition of interleukin-4 production" NARROW [] +synonym: "negative regulation of IL-4 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032673 ! regulation of interleukin-4 production +relationship: negatively_regulates GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0032714 +name: negative regulation of interleukin-5 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] +synonym: "down regulation of interleukin-5 production" EXACT [] +synonym: "down-regulation of interleukin-5 production" EXACT [] +synonym: "downregulation of interleukin-5 production" EXACT [] +synonym: "inhibition of interleukin-5 production" NARROW [] +synonym: "negative regulation of IL-5 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032674 ! regulation of interleukin-5 production +relationship: negatively_regulates GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0032715 +name: negative regulation of interleukin-6 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] +synonym: "down regulation of interleukin-6 production" EXACT [] +synonym: "down-regulation of interleukin-6 production" EXACT [] +synonym: "downregulation of interleukin-6 production" EXACT [] +synonym: "inhibition of interleukin-6 production" NARROW [] +synonym: "negative regulation of IL-6 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032675 ! regulation of interleukin-6 production +relationship: negatively_regulates GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0032716 +name: negative regulation of interleukin-7 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah] +synonym: "down regulation of interleukin-7 production" EXACT [] +synonym: "down-regulation of interleukin-7 production" EXACT [] +synonym: "downregulation of interleukin-7 production" EXACT [] +synonym: "inhibition of interleukin-7 production" NARROW [] +synonym: "negative regulation of IL-7 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032676 ! regulation of interleukin-7 production +relationship: negatively_regulates GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0032717 +name: negative regulation of interleukin-8 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] +synonym: "down regulation of interleukin-8 production" EXACT [] +synonym: "down-regulation of interleukin-8 production" EXACT [] +synonym: "downregulation of interleukin-8 production" EXACT [] +synonym: "inhibition of interleukin-8 production" NARROW [] +synonym: "negative regulation of IL-8 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032677 ! regulation of interleukin-8 production +relationship: negatively_regulates GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0032718 +name: negative regulation of interleukin-9 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] +synonym: "down regulation of interleukin-9 production" EXACT [] +synonym: "down-regulation of interleukin-9 production" EXACT [] +synonym: "downregulation of interleukin-9 production" EXACT [] +synonym: "inhibition of interleukin-9 production" NARROW [] +synonym: "negative regulation of IL-9 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032678 ! regulation of interleukin-9 production +relationship: negatively_regulates GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0032719 +name: negative regulation of TRAIL production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah] +synonym: "down regulation of TRAIL production" EXACT [] +synonym: "down-regulation of TRAIL production" EXACT [] +synonym: "downregulation of TRAIL production" EXACT [] +synonym: "inhibition of TRAIL production" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032679 ! regulation of TRAIL production +relationship: negatively_regulates GO:0032639 ! TRAIL production + +[Term] +id: GO:0032720 +name: negative regulation of tumor necrosis factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "down regulation of tumor necrosis factor production" EXACT [] +synonym: "down-regulation of tumor necrosis factor production" EXACT [] +synonym: "downregulation of tumor necrosis factor production" EXACT [] +synonym: "inhibition of tumor necrosis factor production" NARROW [] +synonym: "negative regulation TNF production" EXACT [] +synonym: "negative regulation TNF-alpha production" EXACT [] +synonym: "negative regulation tumor necrosis factor-alpha production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032680 ! regulation of tumor necrosis factor production +relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0032721 +name: negative regulation of lymphotoxin A production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] +synonym: "down regulation of lymphotoxin A production" EXACT [] +synonym: "down-regulation of lymphotoxin A production" EXACT [] +synonym: "downregulation of lymphotoxin A production" EXACT [] +synonym: "inhibition of lymphotoxin A production" NARROW [] +synonym: "negative regulation of LTA production" EXACT [] +synonym: "negative regulation of lymphotoxin-alpha production" EXACT [] +synonym: "negative regulation of TNF-beta production" EXACT [] +synonym: "negative regulation of tumor necrosis factor-beta production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032681 ! regulation of lymphotoxin A production +relationship: negatively_regulates GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0032722 +name: positive regulation of chemokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah] +synonym: "activation of chemokine production" NARROW [] +synonym: "stimulation of chemokine production" NARROW [] +synonym: "up regulation of chemokine production" EXACT [] +synonym: "up-regulation of chemokine production" EXACT [] +synonym: "upregulation of chemokine production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032642 ! regulation of chemokine production +relationship: positively_regulates GO:0032602 ! chemokine production + +[Term] +id: GO:0032723 +name: positive regulation of connective tissue growth factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] +synonym: "activation of connective tissue growth factor production" NARROW [] +synonym: "positive regulation of CCN2 production" EXACT [] +synonym: "positive regulation of CTGF production" EXACT [] +synonym: "positive regulation of Fisp12 production" EXACT [] +synonym: "positive regulation of Hcs24 production" EXACT [] +synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "positive regulation of IGFBP8 production" EXACT [] +synonym: "stimulation of connective tissue growth factor production" NARROW [] +synonym: "up regulation of connective tissue growth factor production" EXACT [] +synonym: "up-regulation of connective tissue growth factor production" EXACT [] +synonym: "upregulation of connective tissue growth factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032643 ! regulation of connective tissue growth factor production +relationship: positively_regulates GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0032724 +name: positive regulation of fractalkine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah] +synonym: "activation of fractalkine production" NARROW [] +synonym: "stimulation of fractalkine production" NARROW [] +synonym: "up regulation of fractalkine production" EXACT [] +synonym: "up-regulation of fractalkine production" EXACT [] +synonym: "upregulation of fractalkine production" EXACT [] +is_a: GO:0032644 ! regulation of fractalkine production +is_a: GO:0032722 ! positive regulation of chemokine production +relationship: positively_regulates GO:0032603 ! fractalkine production + +[Term] +id: GO:0032725 +name: positive regulation of granulocyte macrophage colony-stimulating factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] +synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW [] +synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW [] +synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production +relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0032726 +name: positive regulation of hepatocyte growth factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] +synonym: "activation of hepatocyte growth factor production" NARROW [] +synonym: "stimulation of hepatocyte growth factor production" NARROW [] +synonym: "up regulation of hepatocyte growth factor production" EXACT [] +synonym: "up-regulation of hepatocyte growth factor production" EXACT [] +synonym: "upregulation of hepatocyte growth factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032646 ! regulation of hepatocyte growth factor production +relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0032727 +name: positive regulation of interferon-alpha production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah] +synonym: "activation of interferon-alpha production" NARROW [] +synonym: "stimulation of interferon-alpha production" NARROW [] +synonym: "up regulation of interferon-alpha production" EXACT [] +synonym: "up-regulation of interferon-alpha production" EXACT [] +synonym: "upregulation of interferon-alpha production" EXACT [] +is_a: GO:0032481 ! positive regulation of type I interferon production +is_a: GO:0032647 ! regulation of interferon-alpha production +relationship: positively_regulates GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0032728 +name: positive regulation of interferon-beta production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah] +synonym: "activation of interferon-beta production" NARROW [] +synonym: "stimulation of interferon-beta production" NARROW [] +synonym: "up regulation of interferon-beta production" EXACT [] +synonym: "up-regulation of interferon-beta production" EXACT [] +synonym: "upregulation of interferon-beta production" EXACT [] +is_a: GO:0032481 ! positive regulation of type I interferon production +is_a: GO:0032648 ! regulation of interferon-beta production +relationship: positively_regulates GO:0032608 ! interferon-beta production + +[Term] +id: GO:0032729 +name: positive regulation of interferon-gamma production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] +synonym: "activation of interferon-gamma production" NARROW [] +synonym: "positive regulation of type II interferon production" EXACT [] +synonym: "stimulation of interferon-gamma production" NARROW [] +synonym: "up regulation of interferon-gamma production" EXACT [] +synonym: "up-regulation of interferon-gamma production" EXACT [] +synonym: "upregulation of interferon-gamma production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032649 ! regulation of interferon-gamma production +relationship: positively_regulates GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0032730 +name: positive regulation of interleukin-1 alpha production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] +synonym: "activation of interleukin-1 alpha production" NARROW [] +synonym: "positive regulation of IL-1 alpha production" EXACT [] +synonym: "stimulation of interleukin-1 alpha production" NARROW [] +synonym: "up regulation of interleukin-1 alpha production" EXACT [] +synonym: "up-regulation of interleukin-1 alpha production" EXACT [] +synonym: "upregulation of interleukin-1 alpha production" EXACT [] +is_a: GO:0032650 ! regulation of interleukin-1 alpha production +is_a: GO:0032732 ! positive regulation of interleukin-1 production +relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0032731 +name: positive regulation of interleukin-1 beta production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] +synonym: "activation of interleukin-1 beta production" NARROW [] +synonym: "positive regulation of IL-1 beta production" EXACT [] +synonym: "stimulation of interleukin-1 beta production" NARROW [] +synonym: "up regulation of interleukin-1 beta production" EXACT [] +synonym: "up-regulation of interleukin-1 beta production" EXACT [] +synonym: "upregulation of interleukin-1 beta production" EXACT [] +is_a: GO:0032651 ! regulation of interleukin-1 beta production +is_a: GO:0032732 ! positive regulation of interleukin-1 production +relationship: positively_regulates GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0032732 +name: positive regulation of interleukin-1 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] +synonym: "activation of interleukin-1 production" NARROW [] +synonym: "positive regulation of IL-1 production" EXACT [] +synonym: "stimulation of interleukin-1 production" NARROW [] +synonym: "up regulation of interleukin-1 production" EXACT [] +synonym: "up-regulation of interleukin-1 production" EXACT [] +synonym: "upregulation of interleukin-1 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: positively_regulates GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032733 +name: positive regulation of interleukin-10 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] +synonym: "activation of interleukin-10 production" NARROW [] +synonym: "positive regulation of IL-10 production" EXACT [] +synonym: "stimulation of interleukin-10 production" NARROW [] +synonym: "up regulation of interleukin-10 production" EXACT [] +synonym: "up-regulation of interleukin-10 production" EXACT [] +synonym: "upregulation of interleukin-10 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032653 ! regulation of interleukin-10 production +relationship: positively_regulates GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0032734 +name: positive regulation of interleukin-11 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah] +synonym: "activation of interleukin-11 production" NARROW [] +synonym: "positive regulation of IL-11 production" EXACT [] +synonym: "stimulation of interleukin-11 production" NARROW [] +synonym: "up regulation of interleukin-11 production" EXACT [] +synonym: "up-regulation of interleukin-11 production" EXACT [] +synonym: "upregulation of interleukin-11 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032654 ! regulation of interleukin-11 production +relationship: positively_regulates GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0032735 +name: positive regulation of interleukin-12 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "activation of interleukin-12 production" NARROW [] +synonym: "positive regulation of IL-12 production" EXACT [] +synonym: "stimulation of interleukin-12 production" NARROW [] +synonym: "up regulation of interleukin-12 production" EXACT [] +synonym: "up-regulation of interleukin-12 production" EXACT [] +synonym: "upregulation of interleukin-12 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032655 ! regulation of interleukin-12 production +relationship: positively_regulates GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0032736 +name: positive regulation of interleukin-13 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] +synonym: "activation of interleukin-13 production" NARROW [] +synonym: "positive regulation of IL-13 production" EXACT [] +synonym: "stimulation of interleukin-13 production" NARROW [] +synonym: "up regulation of interleukin-13 production" EXACT [] +synonym: "up-regulation of interleukin-13 production" EXACT [] +synonym: "upregulation of interleukin-13 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032656 ! regulation of interleukin-13 production +relationship: positively_regulates GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0032737 +name: positive regulation of interleukin-14 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah] +synonym: "activation of interleukin-14 production" NARROW [] +synonym: "positive regulation of IL-14 production" EXACT [] +synonym: "stimulation of interleukin-14 production" NARROW [] +synonym: "up regulation of interleukin-14 production" EXACT [] +synonym: "up-regulation of interleukin-14 production" EXACT [] +synonym: "upregulation of interleukin-14 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032657 ! regulation of interleukin-14 production +relationship: positively_regulates GO:0032617 ! interleukin-14 production + +[Term] +id: GO:0032738 +name: positive regulation of interleukin-15 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah] +synonym: "activation of interleukin-15 production" NARROW [] +synonym: "positive regulation of IL-15 production" EXACT [] +synonym: "stimulation of interleukin-15 production" NARROW [] +synonym: "up regulation of interleukin-15 production" EXACT [] +synonym: "up-regulation of interleukin-15 production" EXACT [] +synonym: "upregulation of interleukin-15 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032658 ! regulation of interleukin-15 production +relationship: positively_regulates GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0032739 +name: positive regulation of interleukin-16 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah] +synonym: "activation of interleukin-16 production" NARROW [] +synonym: "positive regulation of IL-16 production" EXACT [] +synonym: "stimulation of interleukin-16 production" NARROW [] +synonym: "up regulation of interleukin-16 production" EXACT [] +synonym: "up-regulation of interleukin-16 production" EXACT [] +synonym: "upregulation of interleukin-16 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032659 ! regulation of interleukin-16 production +relationship: positively_regulates GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0032740 +name: positive regulation of interleukin-17 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-17 production." [GOC:mah] +synonym: "activation of interleukin-17 production" NARROW [] +synonym: "positive regulation of IL-17 production" EXACT [] +synonym: "stimulation of interleukin-17 production" NARROW [] +synonym: "up regulation of interleukin-17 production" EXACT [] +synonym: "up-regulation of interleukin-17 production" EXACT [] +synonym: "upregulation of interleukin-17 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032660 ! regulation of interleukin-17 production +relationship: positively_regulates GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0032741 +name: positive regulation of interleukin-18 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah] +synonym: "activation of interleukin-18 production" NARROW [] +synonym: "positive regulation of IL-18 production" EXACT [] +synonym: "stimulation of interleukin-18 production" NARROW [] +synonym: "up regulation of interleukin-18 production" EXACT [] +synonym: "up-regulation of interleukin-18 production" EXACT [] +synonym: "upregulation of interleukin-18 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032661 ! regulation of interleukin-18 production +relationship: positively_regulates GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0032742 +name: positive regulation of interleukin-19 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah] +synonym: "activation of interleukin-19 production" NARROW [] +synonym: "positive regulation of IL-19 production" EXACT [] +synonym: "stimulation of interleukin-19 production" NARROW [] +synonym: "up regulation of interleukin-19 production" EXACT [] +synonym: "up-regulation of interleukin-19 production" EXACT [] +synonym: "upregulation of interleukin-19 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032662 ! regulation of interleukin-19 production +relationship: positively_regulates GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0032743 +name: positive regulation of interleukin-2 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] +synonym: "activation of interleukin-2 production" NARROW [] +synonym: "positive regulation of IL-2 production" EXACT [] +synonym: "stimulation of interleukin-2 production" NARROW [] +synonym: "up regulation of interleukin-2 production" EXACT [] +synonym: "up-regulation of interleukin-2 production" EXACT [] +synonym: "upregulation of interleukin-2 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032663 ! regulation of interleukin-2 production +relationship: positively_regulates GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0032744 +name: positive regulation of interleukin-20 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah] +synonym: "activation of interleukin-20 production" NARROW [] +synonym: "positive regulation of IL-20 production" EXACT [] +synonym: "stimulation of interleukin-20 production" NARROW [] +synonym: "up regulation of interleukin-20 production" EXACT [] +synonym: "up-regulation of interleukin-20 production" EXACT [] +synonym: "upregulation of interleukin-20 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032664 ! regulation of interleukin-20 production +relationship: positively_regulates GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0032745 +name: positive regulation of interleukin-21 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah] +synonym: "activation of interleukin-21 production" NARROW [] +synonym: "positive regulation of IL-21 production" EXACT [] +synonym: "stimulation of interleukin-21 production" NARROW [] +synonym: "up regulation of interleukin-21 production" EXACT [] +synonym: "up-regulation of interleukin-21 production" EXACT [] +synonym: "upregulation of interleukin-21 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032665 ! regulation of interleukin-21 production +relationship: positively_regulates GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0032746 +name: positive regulation of interleukin-22 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] +synonym: "activation of interleukin-22 production" NARROW [] +synonym: "positive regulation of IL-22 production" EXACT [] +synonym: "stimulation of interleukin-22 production" NARROW [] +synonym: "up regulation of interleukin-22 production" EXACT [] +synonym: "up-regulation of interleukin-22 production" EXACT [] +synonym: "upregulation of interleukin-22 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032666 ! regulation of interleukin-22 production +relationship: positively_regulates GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0032747 +name: positive regulation of interleukin-23 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "activation of interleukin-23 production" NARROW [] +synonym: "positive regulation of IL-23 production" EXACT [] +synonym: "stimulation of interleukin-23 production" NARROW [] +synonym: "up regulation of interleukin-23 production" EXACT [] +synonym: "up-regulation of interleukin-23 production" EXACT [] +synonym: "upregulation of interleukin-23 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032667 ! regulation of interleukin-23 production +relationship: positively_regulates GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0032748 +name: positive regulation of interleukin-24 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah] +synonym: "activation of interleukin-24 production" NARROW [] +synonym: "positive regulation of IL-24 production" EXACT [] +synonym: "stimulation of interleukin-24 production" NARROW [] +synonym: "up regulation of interleukin-24 production" EXACT [] +synonym: "up-regulation of interleukin-24 production" EXACT [] +synonym: "upregulation of interleukin-24 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032668 ! regulation of interleukin-24 production +relationship: positively_regulates GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0032749 +name: positive regulation of interleukin-25 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah] +synonym: "activation of interleukin-25 production" NARROW [] +synonym: "positive regulation of IL-25 production" EXACT [] +synonym: "stimulation of interleukin-25 production" NARROW [] +synonym: "up regulation of interleukin-25 production" EXACT [] +synonym: "up-regulation of interleukin-25 production" EXACT [] +synonym: "upregulation of interleukin-25 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032669 ! regulation of interleukin-25 production +relationship: positively_regulates GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0032750 +name: positive regulation of interleukin-26 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah] +synonym: "activation of interleukin-26 production" NARROW [] +synonym: "positive regulation of IL-26 production" EXACT [] +synonym: "stimulation of interleukin-26 production" NARROW [] +synonym: "up regulation of interleukin-26 production" EXACT [] +synonym: "up-regulation of interleukin-26 production" EXACT [] +synonym: "upregulation of interleukin-26 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032670 ! regulation of interleukin-26 production +relationship: positively_regulates GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0032751 +name: positive regulation of interleukin-27 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah] +synonym: "activation of interleukin-27 production" NARROW [] +synonym: "positive regulation of IL-27 production" EXACT [] +synonym: "stimulation of interleukin-27 production" NARROW [] +synonym: "up regulation of interleukin-27 production" EXACT [] +synonym: "up-regulation of interleukin-27 production" EXACT [] +synonym: "upregulation of interleukin-27 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032671 ! regulation of interleukin-27 production +relationship: positively_regulates GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0032752 +name: positive regulation of interleukin-3 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah] +synonym: "activation of interleukin-3 production" NARROW [] +synonym: "positive regulation of IL-3 production" EXACT [] +synonym: "stimulation of interleukin-3 production" NARROW [] +synonym: "up regulation of interleukin-3 production" EXACT [] +synonym: "up-regulation of interleukin-3 production" EXACT [] +synonym: "upregulation of interleukin-3 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032672 ! regulation of interleukin-3 production +relationship: positively_regulates GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0032753 +name: positive regulation of interleukin-4 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] +synonym: "activation of interleukin-4 production" NARROW [] +synonym: "positive regulation of IL-4 production" EXACT [] +synonym: "stimulation of interleukin-4 production" NARROW [] +synonym: "up regulation of interleukin-4 production" EXACT [] +synonym: "up-regulation of interleukin-4 production" EXACT [] +synonym: "upregulation of interleukin-4 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032673 ! regulation of interleukin-4 production +relationship: positively_regulates GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0032754 +name: positive regulation of interleukin-5 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] +synonym: "activation of interleukin-5 production" NARROW [] +synonym: "positive regulation of IL-5 production" EXACT [] +synonym: "stimulation of interleukin-5 production" NARROW [] +synonym: "up regulation of interleukin-5 production" EXACT [] +synonym: "up-regulation of interleukin-5 production" EXACT [] +synonym: "upregulation of interleukin-5 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032674 ! regulation of interleukin-5 production +relationship: positively_regulates GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0032755 +name: positive regulation of interleukin-6 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] +synonym: "activation of interleukin-6 production" NARROW [] +synonym: "positive regulation of IL-6 production" EXACT [] +synonym: "stimulation of interleukin-6 production" NARROW [] +synonym: "up regulation of interleukin-6 production" EXACT [] +synonym: "up-regulation of interleukin-6 production" EXACT [] +synonym: "upregulation of interleukin-6 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032675 ! regulation of interleukin-6 production +relationship: positively_regulates GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0032756 +name: positive regulation of interleukin-7 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah] +synonym: "activation of interleukin-7 production" NARROW [] +synonym: "positive regulation of IL-7 production" EXACT [] +synonym: "stimulation of interleukin-7 production" NARROW [] +synonym: "up regulation of interleukin-7 production" EXACT [] +synonym: "up-regulation of interleukin-7 production" EXACT [] +synonym: "upregulation of interleukin-7 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032676 ! regulation of interleukin-7 production +relationship: positively_regulates GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0032757 +name: positive regulation of interleukin-8 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] +synonym: "activation of interleukin-8 production" NARROW [] +synonym: "positive regulation of IL-8 production" EXACT [] +synonym: "stimulation of interleukin-8 production" NARROW [] +synonym: "up regulation of interleukin-8 production" EXACT [] +synonym: "up-regulation of interleukin-8 production" EXACT [] +synonym: "upregulation of interleukin-8 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032677 ! regulation of interleukin-8 production +relationship: positively_regulates GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0032758 +name: positive regulation of interleukin-9 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] +synonym: "activation of interleukin-9 production" NARROW [] +synonym: "positive regulation of IL-9 production" EXACT [] +synonym: "stimulation of interleukin-9 production" NARROW [] +synonym: "up regulation of interleukin-9 production" EXACT [] +synonym: "up-regulation of interleukin-9 production" EXACT [] +synonym: "upregulation of interleukin-9 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032678 ! regulation of interleukin-9 production +relationship: positively_regulates GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0032759 +name: positive regulation of TRAIL production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah] +synonym: "activation of TRAIL production" NARROW [] +synonym: "stimulation of TRAIL production" NARROW [] +synonym: "up regulation of TRAIL production" EXACT [] +synonym: "up-regulation of TRAIL production" EXACT [] +synonym: "upregulation of TRAIL production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032679 ! regulation of TRAIL production +relationship: positively_regulates GO:0032639 ! TRAIL production + +[Term] +id: GO:0032760 +name: positive regulation of tumor necrosis factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "activation of tumor necrosis factor production" NARROW [] +synonym: "positive regulation of TNF production" EXACT [] +synonym: "positive regulation of TNF-alpha production" EXACT [] +synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT [] +synonym: "stimulation of tumor necrosis factor production" NARROW [] +synonym: "up regulation of tumor necrosis factor production" EXACT [] +synonym: "up-regulation of tumor necrosis factor production" EXACT [] +synonym: "upregulation of tumor necrosis factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032680 ! regulation of tumor necrosis factor production +relationship: positively_regulates GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0032761 +name: positive regulation of lymphotoxin A production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] +synonym: "activation of lymphotoxin A production" NARROW [] +synonym: "positive regulation of LTA production" EXACT [] +synonym: "positive regulation of lymphotoxin-alpha production" EXACT [] +synonym: "positive regulation of TNF-beta production" EXACT [] +synonym: "positive regulation of tumor necrosis factor-beta production" EXACT [] +synonym: "stimulation of lymphotoxin A production" NARROW [] +synonym: "up regulation of lymphotoxin A production" EXACT [] +synonym: "up-regulation of lymphotoxin A production" EXACT [] +synonym: "upregulation of lymphotoxin A production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032681 ! regulation of lymphotoxin A production +relationship: positively_regulates GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0032762 +name: mast cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah] +is_a: GO:0002367 ! cytokine production during immune response + +[Term] +id: GO:0032763 +name: regulation of mast cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] +is_a: GO:0002718 ! regulation of cytokine production during immune response +relationship: regulates GO:0032762 ! mast cell cytokine production + +[Term] +id: GO:0032764 +name: negative regulation of mast cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] +synonym: "down regulation of mast cell cytokine production" EXACT [] +synonym: "down-regulation of mast cell cytokine production" EXACT [] +synonym: "downregulation of mast cell cytokine production" EXACT [] +synonym: "inhibition of mast cell cytokine production" NARROW [] +is_a: GO:0002719 ! negative regulation of cytokine production during immune response +is_a: GO:0032763 ! regulation of mast cell cytokine production +relationship: negatively_regulates GO:0032762 ! mast cell cytokine production + +[Term] +id: GO:0032765 +name: positive regulation of mast cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] +synonym: "activation of mast cell cytokine production" NARROW [] +synonym: "stimulation of mast cell cytokine production" NARROW [] +synonym: "up regulation of mast cell cytokine production" EXACT [] +synonym: "up-regulation of mast cell cytokine production" EXACT [] +synonym: "upregulation of mast cell cytokine production" EXACT [] +is_a: GO:0002720 ! positive regulation of cytokine production during immune response +is_a: GO:0032763 ! regulation of mast cell cytokine production +relationship: positively_regulates GO:0032762 ! mast cell cytokine production + +[Term] +id: GO:0032766 +name: NHE3/E3KARP/ACTN4 complex +namespace: cellular_component +def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184] +synonym: " NHE3/E3KARP/alpha-actinin complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0032767 +name: copper-dependent protein binding +namespace: molecular_function +def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032768 +name: regulation of monooxygenase activity +namespace: biological_process +def: "Any process that modulates the activity of a monooxygenase." [GOC:mah] +subset: gosubset_prok +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0032769 +name: negative regulation of monooxygenase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah] +synonym: "down regulation of monooxygenase activity" EXACT [] +synonym: "down-regulation of monooxygenase activity" EXACT [] +synonym: "downregulation of monooxygenase activity" EXACT [] +synonym: "inhibition of monooxygenase activity" NARROW [] +is_a: GO:0032768 ! regulation of monooxygenase activity +is_a: GO:0051354 ! negative regulation of oxidoreductase activity + +[Term] +id: GO:0032770 +name: positive regulation of monooxygenase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah] +synonym: "activation of monooxygenase activity" NARROW [] +synonym: "stimulation of monooxygenase activity" NARROW [] +synonym: "up regulation of monooxygenase activity" EXACT [] +synonym: "up-regulation of monooxygenase activity" EXACT [] +synonym: "upregulation of monooxygenase activity" EXACT [] +is_a: GO:0032768 ! regulation of monooxygenase activity +is_a: GO:0051353 ! positive regulation of oxidoreductase activity + +[Term] +id: GO:0032771 +name: regulation of monophenol monooxygenase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] +synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0032772 +name: negative regulation of monophenol monooxygenase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of monophenol oxygenase activity" EXACT [] +synonym: "down-regulation of monophenol oxygenase activity" EXACT [] +synonym: "downregulation of monophenol oxygenase activity" EXACT [] +synonym: "inhibition of monophenol oxygenase activity" NARROW [] +synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:0032771 ! regulation of monophenol monooxygenase activity + +[Term] +id: GO:0032773 +name: positive regulation of monophenol monooxygenase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme monophenol oxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] +synonym: "activation of monophenol oxygenase activity" NARROW [] +synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] +synonym: "stimulation of monophenol oxygenase activity" NARROW [] +synonym: "up regulation of monophenol oxygenase activity" EXACT [] +synonym: "up-regulation of monophenol oxygenase activity" EXACT [] +synonym: "upregulation of monophenol oxygenase activity" EXACT [] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:0032771 ! regulation of monophenol monooxygenase activity + +[Term] +id: GO:0032774 +name: RNA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers." [GOC:mah] +synonym: "RNA anabolism" EXACT [] +synonym: "RNA biosynthesis" EXACT [] +synonym: "RNA formation" EXACT [] +synonym: "RNA synthesis" EXACT [] +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0032775 +name: DNA methylation on adenine +namespace: biological_process +def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf] +synonym: "adenine methylation" RELATED [] +is_a: GO:0006306 ! DNA methylation + +[Term] +id: GO:0032776 +name: DNA methylation on cytosine +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf] +synonym: "cytosine methylation" RELATED [] +is_a: GO:0006306 ! DNA methylation + +[Term] +id: GO:0032777 +name: Piccolo NuA4 histone acetyltransferase complex +namespace: cellular_component +def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [PMID:12782659, PMID:15964809] +is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex + +[Term] +id: GO:0032778 +name: cobalt-transporting ATPase activity +namespace: molecular_function +alt_id: GO:0015632 +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] +synonym: "cobalt ABC transporter" RELATED [] +synonym: "cobalt porter activity" RELATED [] +synonym: "cobalt transporting ATPase activity" EXACT [] +is_a: GO:0015087 ! cobalt ion transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0032779 +name: copper-induced intracellular protein transport +namespace: biological_process +def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell, induced by an increase in copper ion concentration." [GOC:ecd, PMID:12572677] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0032780 +name: negative regulation of ATPase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of ATP hydrolysis by an ATPase." [GOC:mah] +synonym: "down regulation of ATPase activity" EXACT [] +synonym: "down-regulation of ATPase activity" EXACT [] +synonym: "downregulation of ATPase activity" EXACT [] +synonym: "inhibition of ATPase activity" NARROW [] +synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] +is_a: GO:0043462 ! regulation of ATPase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0032781 +name: positive regulation of ATPase activity +namespace: biological_process +def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah] +synonym: "activation of ATPase activity" NARROW [] +synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] +synonym: "stimulation of ATPase activity" NARROW [] +synonym: "up regulation of ATPase activity" EXACT [] +synonym: "up-regulation of ATPase activity" EXACT [] +synonym: "upregulation of ATPase activity" EXACT [] +is_a: GO:0043462 ! regulation of ATPase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0032782 +name: bile acid secretion +namespace: biological_process +def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or group of cells." [GOC:ecd] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0032783 +name: ELL-EAF complex +namespace: cellular_component +def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0032784 +name: regulation of RNA elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah] +synonym: "regulation of transcription elongation" BROAD [] +synonym: "regulation of transcriptional elongation" BROAD [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +relationship: regulates GO:0006354 ! RNA elongation + +[Term] +id: GO:0032785 +name: negative regulation of RNA elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah] +synonym: "down regulation of RNA elongation" EXACT [] +synonym: "down-regulation of RNA elongation" EXACT [] +synonym: "downregulation of RNA elongation" EXACT [] +synonym: "inhibition of RNA elongation" NARROW [] +synonym: "negative regulation of transcription elongation" BROAD [] +synonym: "negative regulation of transcriptional elongation" BROAD [] +is_a: GO:0032784 ! regulation of RNA elongation +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0006354 ! RNA elongation + +[Term] +id: GO:0032786 +name: positive regulation of RNA elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah] +synonym: "activation of RNA elongation" NARROW [] +synonym: "positive regulation of transcription elongation" BROAD [] +synonym: "positive regulation of transcriptional elongation" BROAD [] +synonym: "stimulation of RNA elongation" NARROW [] +synonym: "up regulation of RNA elongation" EXACT [] +synonym: "up-regulation of RNA elongation" EXACT [] +synonym: "upregulation of RNA elongation" EXACT [] +is_a: GO:0032784 ! regulation of RNA elongation +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0006354 ! RNA elongation + +[Term] +id: GO:0032787 +name: monocarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] +subset: gosubset_prok +synonym: "monocarboxylate metabolic process" EXACT [] +synonym: "monocarboxylic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0032788 +name: saturated monocarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk] +synonym: "saturated monocarboxylate metabolic process" EXACT [] +synonym: "saturated monocarboxylic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0032789 +name: unsaturated monocarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk] +synonym: "unsaturated monocarboxylate metabolic process" EXACT [] +synonym: "unsaturated monocarboxylic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0032790 +name: ribosome disassembly +namespace: biological_process +def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] +synonym: "ribosome dissociation factor" RELATED [] +is_a: GO:0032988 ! ribonucleoprotein complex disassembly + +[Term] +id: GO:0032791 +name: lead ion binding +namespace: molecular_function +def: "Interacting selectively with lead (Pb) ions." [GOC:mah] +subset: goslim_generic +subset: gosubset_prok +is_a: GO:0043169 ! cation binding +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0032792 +name: negative regulation of CREB transcription factor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] +synonym: "CREB inhibitor" RELATED [] +synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043433 ! negative regulation of transcription factor activity + +[Term] +id: GO:0032793 +name: positive regulation of CREB transcription factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] +synonym: "activation of CREB" EXACT [] +synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "CREB activator" RELATED [] +is_a: GO:0051091 ! positive regulation of transcription factor activity + +[Term] +id: GO:0032794 +name: GTPase activating protein binding +namespace: molecular_function +def: "Interacting selectively with a GTPase activating protein." [GOC:nln] +synonym: "GAP binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032795 +name: heterotrimeric G-protein binding +namespace: molecular_function +def: "Interacting selectively with a heterotrimeric G-protein." [GOC:nln] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0032796 +name: uropod organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750] +synonym: "uropod organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0032797 +name: SMN complex +namespace: cellular_component +def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] +comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. +synonym: "SMN core complex" EXACT [] +synonym: "survival motor neuron complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0032798 +name: Swi5-Sfr1 complex +namespace: cellular_component +def: "A conserved eukaryotic protein complex involved in DNA recombinational repair; in Schizosaccharomyces the complex contains two Swi5 monomers and one Sfr1 monomer." [PMID:16921379] +comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p. +synonym: "Swi5 complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000790 ! nuclear chromatin + +[Term] +id: GO:0032799 +name: low-density lipoprotein receptor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk] +synonym: "LDL receptor metabolic process" EXACT [] +synonym: "low-density lipoprotein receptor metabolism" EXACT [] +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0032800 +name: receptor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] +synonym: "receptor anabolism" EXACT [] +synonym: "receptor biosynthesis" EXACT [] +synonym: "receptor formation" EXACT [] +synonym: "receptor synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0032801 +name: receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] +synonym: "receptor breakdown" EXACT [] +synonym: "receptor catabolism" EXACT [] +synonym: "receptor degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0032802 +name: low-density lipoprotein receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] +synonym: "LDL receptor breakdown" EXACT [] +synonym: "LDL receptor catabolic process" EXACT [] +synonym: "LDL receptor catabolism" RELATED [] +synonym: "LDL receptor degradation" EXACT [] +synonym: "low-density lipoprotein receptor breakdown" EXACT [] +synonym: "low-density lipoprotein receptor catabolism" EXACT [] +synonym: "low-density lipoprotein receptor degradation" EXACT [] +is_a: GO:0032799 ! low-density lipoprotein receptor metabolic process +is_a: GO:0032801 ! receptor catabolic process + +[Term] +id: GO:0032803 +name: regulation of low-density lipoprotein receptor catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] +synonym: "regulation of LDLr catabolic process" EXACT [] +synonym: "regulation of LDLr catabolism" EXACT [] +synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT [] +synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT [] +synonym: "regulation of low-density lipoprotein receptor degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0032802 ! low-density lipoprotein receptor catabolic process + +[Term] +id: GO:0032804 +name: negative regulation of low-density lipoprotein receptor catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] +synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW [] +synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0032803 ! regulation of low-density lipoprotein receptor catabolic process +relationship: negatively_regulates GO:0032802 ! low-density lipoprotein receptor catabolic process + +[Term] +id: GO:0032805 +name: positive regulation of low-density lipoprotein receptor catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] +synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW [] +synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT [] +synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW [] +synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0032803 ! regulation of low-density lipoprotein receptor catabolic process +relationship: positively_regulates GO:0032802 ! low-density lipoprotein receptor catabolic process + +[Term] +id: GO:0032806 +name: carboxy-terminal domain protein kinase complex +namespace: cellular_component +def: "A protein complex that phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats; in Saccharomyces the complex contains Ctk1p, Ctk2p, and Ctk3p." [PMID:15047695, PMID:16721054] +synonym: "CTDK complex" EXACT [] +synonym: "CTDK-1" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0032807 +name: DNA ligase IV complex +namespace: cellular_component +def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0032808 +name: lacrimal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035272 ! exocrine system development + +[Term] +id: GO:0032809 +name: cell soma membrane +namespace: cellular_component +def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd] +synonym: "cell body membrane" EXACT [] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0043025 ! cell soma + +[Term] +id: GO:0032810 +name: sterol response element binding +namespace: molecular_function +def: "Interacting selectively with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] +synonym: "SRE binding" EXACT [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0032811 +name: negative regulation of epinephrine secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] +synonym: "down regulation of epinephrine secretion" EXACT [] +synonym: "down-regulation of epinephrine secretion" EXACT [] +synonym: "downregulation of epinephrine secretion" EXACT [] +synonym: "inhibition of epinephrine secretion" NARROW [] +synonym: "negative regulation of adrenaline secretion" EXACT [] +is_a: GO:0014060 ! regulation of epinephrine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion +relationship: negatively_regulates GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0032812 +name: positive regulation of epinephrine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] +synonym: "activation of epinephrine secretion" NARROW [] +synonym: "positive regulation of adrenaline secretion" EXACT [] +synonym: "stimulation of epinephrine secretion" NARROW [] +synonym: "up regulation of epinephrine secretion" EXACT [] +synonym: "up-regulation of epinephrine secretion" EXACT [] +synonym: "upregulation of epinephrine secretion" EXACT [] +is_a: GO:0014060 ! regulation of epinephrine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion +relationship: positively_regulates GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0032813 +name: tumor necrosis factor receptor superfamily binding +namespace: molecular_function +def: "Interacting selectively with any member of the tumor necrosis factor receptor superfamily." [GOC:add] +synonym: "TNF receptor superfamily binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0032814 +name: regulation of natural killer cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] +synonym: "regulation of NK cell activation" EXACT [] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0032815 +name: negative regulation of natural killer cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] +synonym: "down regulation of natural killer cell activation" EXACT [] +synonym: "down-regulation of natural killer cell activation" EXACT [] +synonym: "downregulation of natural killer cell activation" EXACT [] +synonym: "inhibition of natural killer cell activation" NARROW [] +synonym: "negative regulation of NK cell activation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0032816 +name: positive regulation of natural killer cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] +synonym: "activation of natural killer cell activation" NARROW [] +synonym: "positive regulation of NK cell activation" EXACT [] +synonym: "stimulation of natural killer cell activation" NARROW [] +synonym: "up regulation of natural killer cell activation" EXACT [] +synonym: "up-regulation of natural killer cell activation" EXACT [] +synonym: "upregulation of natural killer cell activation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0032817 +name: regulation of natural killer cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] +synonym: "regulation of NK cell proliferation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0050670 ! regulation of lymphocyte proliferation +relationship: regulates GO:0001787 ! natural killer cell proliferation + +[Term] +id: GO:0032818 +name: negative regulation of natural killer cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] +synonym: "down regulation of natural killer cell proliferation" EXACT [] +synonym: "down-regulation of natural killer cell proliferation" EXACT [] +synonym: "downregulation of natural killer cell proliferation" EXACT [] +synonym: "inhibition of natural killer cell proliferation" NARROW [] +synonym: "negative regulation of NK cell proliferation" EXACT [] +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0032817 ! regulation of natural killer cell proliferation +is_a: GO:0050672 ! negative regulation of lymphocyte proliferation +relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation + +[Term] +id: GO:0032819 +name: positive regulation of natural killer cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] +synonym: "activation of natural killer cell proliferation" NARROW [] +synonym: "positive regulation of NK cell proliferation" EXACT [] +synonym: "stimulation of natural killer cell proliferation" NARROW [] +synonym: "up regulation of natural killer cell proliferation" EXACT [] +synonym: "up-regulation of natural killer cell proliferation" EXACT [] +synonym: "upregulation of natural killer cell proliferation" EXACT [] +is_a: GO:0032816 ! positive regulation of natural killer cell activation +is_a: GO:0032817 ! regulation of natural killer cell proliferation +is_a: GO:0050671 ! positive regulation of lymphocyte proliferation +relationship: positively_regulates GO:0001787 ! natural killer cell proliferation + +[Term] +id: GO:0032820 +name: regulation of natural killer cell proliferation during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation during an immune response." [GOC:mah] +synonym: "regulation of NK cell proliferation during immune response" EXACT [] +is_a: GO:0032817 ! regulation of natural killer cell proliferation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002324 ! natural killer cell proliferation during immune response + +[Term] +id: GO:0032821 +name: negative regulation of natural killer cell proliferation during immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation during an immune response." [GOC:mah] +synonym: "down regulation of natural killer cell proliferation during immune response" EXACT [] +synonym: "down-regulation of natural killer cell proliferation during immune response" EXACT [] +synonym: "downregulation of natural killer cell proliferation during immune response" EXACT [] +synonym: "inhibition of natural killer cell proliferation during immune response" NARROW [] +synonym: "negative regulation of NK cell proliferation during immune response" EXACT [] +is_a: GO:0032818 ! negative regulation of natural killer cell proliferation +is_a: GO:0032820 ! regulation of natural killer cell proliferation during immune response +relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation during immune response + +[Term] +id: GO:0032822 +name: positive regulation of natural killer cell proliferation during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation during an immune response." [GOC:mah] +synonym: "activation of natural killer cell proliferation during immune response" NARROW [] +synonym: "positive regulation of NK cell proliferation during immune response" EXACT [] +synonym: "stimulation of natural killer cell proliferation during immune response" NARROW [] +synonym: "up regulation of natural killer cell proliferation during immune response" EXACT [] +synonym: "up-regulation of natural killer cell proliferation during immune response" EXACT [] +synonym: "upregulation of natural killer cell proliferation during immune response" EXACT [] +is_a: GO:0032819 ! positive regulation of natural killer cell proliferation +is_a: GO:0032820 ! regulation of natural killer cell proliferation during immune response +relationship: positively_regulates GO:0002324 ! natural killer cell proliferation during immune response + +[Term] +id: GO:0032823 +name: regulation of natural killer cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] +synonym: "regulation of NK cell differentiation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0045619 ! regulation of lymphocyte differentiation +relationship: regulates GO:0001779 ! natural killer cell differentiation + +[Term] +id: GO:0032824 +name: negative regulation of natural killer cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] +synonym: "down regulation of natural killer cell differentiation" EXACT [] +synonym: "down-regulation of natural killer cell differentiation" EXACT [] +synonym: "downregulation of natural killer cell differentiation" EXACT [] +synonym: "inhibition of natural killer cell differentiation" NARROW [] +synonym: "negative regulation of NK cell differentiation" EXACT [] +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0032823 ! regulation of natural killer cell differentiation +is_a: GO:0045620 ! negative regulation of lymphocyte differentiation +relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation + +[Term] +id: GO:0032825 +name: positive regulation of natural killer cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] +synonym: "activation of natural killer cell differentiation" NARROW [] +synonym: "positive regulation of NK cell differentiation" EXACT [] +synonym: "stimulation of natural killer cell differentiation" NARROW [] +synonym: "up regulation of natural killer cell differentiation" EXACT [] +synonym: "up-regulation of natural killer cell differentiation" EXACT [] +synonym: "upregulation of natural killer cell differentiation" EXACT [] +is_a: GO:0032816 ! positive regulation of natural killer cell activation +is_a: GO:0032823 ! regulation of natural killer cell differentiation +is_a: GO:0045621 ! positive regulation of lymphocyte differentiation +relationship: positively_regulates GO:0001779 ! natural killer cell differentiation + +[Term] +id: GO:0032826 +name: regulation of natural killer cell differentiation during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation during an immune response." [GOC:mah] +synonym: "regulation of NK cell differentiation during immune response" EXACT [] +is_a: GO:0032823 ! regulation of natural killer cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002325 ! natural killer cell differentiation during immune response + +[Term] +id: GO:0032827 +name: negative regulation of natural killer cell differentiation during immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation during an immune response." [GOC:mah] +synonym: "down regulation of natural killer cell differentiation during immune response" EXACT [] +synonym: "down-regulation of natural killer cell differentiation during immune response" EXACT [] +synonym: "downregulation of natural killer cell differentiation during immune response" EXACT [] +synonym: "inhibition of natural killer cell differentiation during immune response" NARROW [] +synonym: "negative regulation of NK cell differentiation during immune response" EXACT [] +is_a: GO:0032824 ! negative regulation of natural killer cell differentiation +is_a: GO:0032826 ! regulation of natural killer cell differentiation during immune response +relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation during immune response + +[Term] +id: GO:0032828 +name: positive regulation of natural killer cell differentiation during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation during an immune response." [GOC:mah] +synonym: "activation of natural killer cell differentiation during immune response" NARROW [] +synonym: "positive regulation of NK cell differentiation during immune response" EXACT [] +synonym: "stimulation of natural killer cell differentiation during immune response" NARROW [] +synonym: "up regulation of natural killer cell differentiation during immune response" EXACT [] +synonym: "up-regulation of natural killer cell differentiation during immune response" EXACT [] +synonym: "upregulation of natural killer cell differentiation during immune response" EXACT [] +is_a: GO:0032825 ! positive regulation of natural killer cell differentiation +is_a: GO:0032826 ! regulation of natural killer cell differentiation during immune response +relationship: positively_regulates GO:0002325 ! natural killer cell differentiation during immune response + +[Term] +id: GO:0032829 +name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0045589 ! regulation of regulatory T cell differentiation +relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0032830 +name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] +synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0043371 ! negative regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation +relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0032831 +name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] +synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] +synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0043372 ! positive regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation +relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0032832 +name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response." [GOC:mah] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response + +[Term] +id: GO:0032833 +name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response." [GOC:mah] +synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT [] +synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT [] +synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT [] +synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT [] +is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response +relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response + +[Term] +id: GO:0032834 +name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response." [GOC:mah] +synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT [] +synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] +synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT [] +synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT [] +synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT [] +is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response +relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response + +[Term] +id: GO:0032835 +name: glomerulus development +namespace: biological_process +def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mah] +synonym: "glomerular development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0032836 +name: glomerular basement membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr] +is_a: GO:0030198 ! extracellular matrix organization +relationship: part_of GO:0032835 ! glomerulus development + +[Term] +id: GO:0032837 +name: distributive segregation +namespace: biological_process +def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] +is_a: GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0032838 +name: cell projection cytoplasm +namespace: cellular_component +def: "All of the contents of a cell projection, excluding the plasma membrane surrounding the projection." [GOC:mah] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044463 ! cell projection part + +[Term] +id: GO:0032839 +name: dendrite cytoplasm +namespace: cellular_component +def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] +synonym: "dendritic cytoplasm" EXACT [] +is_a: GO:0032838 ! cell projection cytoplasm +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0032840 +name: intramolecular proline-rich ligand binding +namespace: molecular_function +def: "Interacting selectively with a proline-rich region within the same polypeptide." [GOC:pf] +synonym: "intramolecular proline-rich region binding" EXACT [] +is_a: GO:0043621 ! protein self-association +is_a: GO:0070064 ! proline-rich region binding + +[Term] +id: GO:0032841 +name: calcitonin binding +namespace: molecular_function +def: "Interacting selectively with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0032843 +name: hydroperoxide reductase +namespace: molecular_function +def: "Catalysis of the reaction:2RSH + ROOH = RSSR + ROH + H2O, i.e. the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol plus water." [GOC:mlg, PMID:12540833] +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0032844 +name: regulation of homeostatic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a homeostatic process." [GOC:mah] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0042592 ! homeostatic process + +[Term] +id: GO:0032845 +name: negative regulation of homeostatic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process." [GOC:mah] +synonym: "down regulation of homeostatic process" EXACT [] +synonym: "down-regulation of homeostatic process" EXACT [] +synonym: "downregulation of homeostatic process" EXACT [] +synonym: "inhibition of homeostatic process" NARROW [] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0042592 ! homeostatic process + +[Term] +id: GO:0032846 +name: positive regulation of homeostatic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a homeostatic process." [GOC:mah] +synonym: "activation of homeostatic process" NARROW [] +synonym: "stimulation of homeostatic process" NARROW [] +synonym: "up regulation of homeostatic process" EXACT [] +synonym: "up-regulation of homeostatic process" EXACT [] +synonym: "upregulation of homeostatic process" EXACT [] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0042592 ! homeostatic process + +[Term] +id: GO:0032847 +name: regulation of cellular pH reduction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] +synonym: "regulation of cell pH reduction" EXACT [] +synonym: "regulation of cellular acidification" EXACT [] +synonym: "regulation of intracellular acidification" RELATED [] +synonym: "regulation of intracellular pH reduction" EXACT [] +synonym: "regulation of reduction of cellular pH" EXACT [] +synonym: "regulation of reduction of pH in cell" EXACT [] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0032848 +name: negative regulation of cellular pH reduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] +synonym: "down regulation of cellular pH reduction" EXACT [] +synonym: "down-regulation of cellular pH reduction" EXACT [] +synonym: "downregulation of cellular pH reduction" EXACT [] +synonym: "inhibition of cellular pH reduction" NARROW [] +synonym: "negative regulation of cell pH reduction" EXACT [] +synonym: "negative regulation of cellular acidification" EXACT [] +synonym: "negative regulation of intracellular acidification" RELATED [] +synonym: "negative regulation of intracellular pH reduction" EXACT [] +synonym: "negative regulation of reduction of cellular pH" EXACT [] +synonym: "negative regulation of reduction of pH in cell" EXACT [] +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0032847 ! regulation of cellular pH reduction +is_a: GO:0048523 ! negative regulation of cellular process + +[Term] +id: GO:0032849 +name: positive regulation of cellular pH reduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] +synonym: "activation of cellular pH reduction" NARROW [] +synonym: "positive regulation of cell pH reduction" EXACT [] +synonym: "positive regulation of cellular acidification" EXACT [] +synonym: "positive regulation of intracellular acidification" RELATED [] +synonym: "positive regulation of intracellular pH reduction" EXACT [] +synonym: "positive regulation of reduction of cellular pH" EXACT [] +synonym: "positive regulation of reduction of pH in cell" EXACT [] +synonym: "stimulation of cellular pH reduction" NARROW [] +synonym: "up regulation of cellular pH reduction" EXACT [] +synonym: "up-regulation of cellular pH reduction" EXACT [] +synonym: "upregulation of cellular pH reduction" EXACT [] +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0032847 ! regulation of cellular pH reduction +is_a: GO:0048522 ! positive regulation of cellular process + +[Term] +id: GO:0032850 +name: positive regulation of ARF GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the GTPase ARF." [GOC:mah] +synonym: "stimulation of ARF GTPase activity" NARROW [] +synonym: "up regulation of ARF GTPase activity" EXACT [] +synonym: "up-regulation of ARF GTPase activity" EXACT [] +synonym: "upregulation of ARF GTPase activity" EXACT [] +is_a: GO:0032312 ! regulation of ARF GTPase activity +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032851 +name: positive regulation of Rab GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Rab family." [GOC:mah] +synonym: "stimulation of Rab GTPase activity" NARROW [] +synonym: "up regulation of Rab GTPase activity" EXACT [] +synonym: "up-regulation of Rab GTPase activity" EXACT [] +synonym: "upregulation of Rab GTPase activity" EXACT [] +is_a: GO:0032313 ! regulation of Rab GTPase activity +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032852 +name: positive regulation of Ral GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Ral family." [GOC:mah] +synonym: "stimulation of Ral GTPase activity" NARROW [] +synonym: "up regulation of Ral GTPase activity" EXACT [] +synonym: "up-regulation of Ral GTPase activity" EXACT [] +synonym: "upregulation of Ral GTPase activity" EXACT [] +is_a: GO:0032315 ! regulation of Ral GTPase activity +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032853 +name: positive regulation of Ran GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Ran family." [GOC:mah] +synonym: "stimulation of Ran GTPase activity" NARROW [] +synonym: "up regulation of Ran GTPase activity" EXACT [] +synonym: "up-regulation of Ran GTPase activity" EXACT [] +synonym: "upregulation of Ran GTPase activity" EXACT [] +is_a: GO:0032316 ! regulation of Ran GTPase activity +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032854 +name: positive regulation of Rap GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Rap family." [GOC:mah] +synonym: "stimulation of Rap GTPase activity" NARROW [] +synonym: "up regulation of Rap GTPase activity" EXACT [] +synonym: "up-regulation of Rap GTPase activity" EXACT [] +synonym: "upregulation of Rap GTPase activity" EXACT [] +is_a: GO:0032317 ! regulation of Rap GTPase activity +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032855 +name: positive regulation of Rac GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase of the Rac family." [GOC:mah] +synonym: "stimulation of Rac GTPase activity" NARROW [] +synonym: "up regulation of Rac GTPase activity" EXACT [] +synonym: "up-regulation of Rac GTPase activity" EXACT [] +synonym: "upregulation of Rac GTPase activity" EXACT [] +is_a: GO:0032321 ! positive regulation of Rho GTPase activity + +[Term] +id: GO:0032856 +name: activation of Ras GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Ras superfamily through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'Ras GTPase activator activity ; GO:0005099', which refers specifically to the activity of Ras GAPs. +synonym: "Ras GTPase activation" EXACT [] +is_a: GO:0032320 ! positive regulation of Ras GTPase activity + +[Term] +id: GO:0032857 +name: activation of ARF GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme ARF GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'ARF GTPase activator activity ; GO:0008060', which refers specifically to the activity of ARF GAPs. +synonym: "ARF GTPase activation" EXACT [] +is_a: GO:0032850 ! positive regulation of ARF GTPase activity +is_a: GO:0032856 ! activation of Ras GTPase activity + +[Term] +id: GO:0032858 +name: activation of Rab GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Rab family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'Rab GTPase activator activity ; GO:0005097', which refers specifically to the activity of Rab GAPs. +synonym: "Rab GTPase activation" EXACT [] +is_a: GO:0032851 ! positive regulation of Rab GTPase activity +is_a: GO:0032856 ! activation of Ras GTPase activity + +[Term] +id: GO:0032859 +name: activation of Ral GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Ral family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'Ral GTPase activator activity ; GO:0017123', which refers specifically to the activity of Ral GAPs. +synonym: "Ral GTPase activation" EXACT [] +is_a: GO:0032852 ! positive regulation of Ral GTPase activity +is_a: GO:0032856 ! activation of Ras GTPase activity + +[Term] +id: GO:0032860 +name: activation of Ran GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Ran family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'Ran GTPase activator activity ; GO:0005098', which refers specifically to the activity of Ran GAPs. +synonym: "Ran GTPase activation" EXACT [] +is_a: GO:0032853 ! positive regulation of Ran GTPase activity +is_a: GO:0032856 ! activation of Ras GTPase activity + +[Term] +id: GO:0032861 +name: activation of Rap GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Rap family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'Rap GTPase activator activity ; GO:0046582', which refers specifically to the activity of Rap GAPs. +synonym: "Rap GTPase activation" EXACT [] +is_a: GO:0032854 ! positive regulation of Rap GTPase activity +is_a: GO:0032856 ! activation of Ras GTPase activity + +[Term] +id: GO:0032862 +name: activation of Rho GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Rho family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +comment: Note that this term should not be confused with the molecular function term 'Rho GTPase activator activity ; GO:0005100', which refers specifically to the activity of Rho GAPs. +synonym: "Rho GTPase activation" EXACT [] +is_a: GO:0032321 ! positive regulation of Rho GTPase activity +is_a: GO:0032856 ! activation of Ras GTPase activity + +[Term] +id: GO:0032863 +name: activation of Rac GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive GTPase of the Rac family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +synonym: "Rac GTPase activation" EXACT [] +is_a: GO:0032855 ! positive regulation of Rac GTPase activity +is_a: GO:0032862 ! activation of Rho GTPase activity + +[Term] +id: GO:0032864 +name: activation of Cdc42 GTPase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive GTPase Cdc42 through the replacement of GDP by GTP." [GOC:mah] +synonym: "Cdc42 GTPase activation" EXACT [] +is_a: GO:0032862 ! activation of Rho GTPase activity +is_a: GO:0043089 ! positive regulation of Cdc42 GTPase activity + +[Term] +id: GO:0032865 +name: Mdm10/Mdm12/Mmm1 complex +namespace: cellular_component +def: "A protein complex that links mtDNA and mitochondrial outer and inner membranes to the cytoskeletal system." [PMID:13679517] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0032866 +name: xylose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173] +is_a: GO:0004032 ! aldehyde reductase activity + +[Term] +id: GO:0032867 +name: arabinose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173] +is_a: GO:0004032 ! aldehyde reductase activity + +[Term] +id: GO:0032868 +name: response to insulin stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043434 ! response to peptide hormone stimulus + +[Term] +id: GO:0032869 +name: cellular response to insulin stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0032868 ! response to insulin stimulus +is_a: GO:0032870 ! cellular response to hormone stimulus + +[Term] +id: GO:0032870 +name: cellular response to hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] +is_a: GO:0009725 ! response to hormone stimulus +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0032871 +name: regulation of karyogamy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0000741 ! karyogamy + +[Term] +id: GO:0032872 +name: regulation of stress-activated MAPK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] +synonym: "regulation of p38 MAPK signaling" EXACT [] +synonym: "regulation of p38 MAPK signalling" EXACT [] +synonym: "regulation of stress-activated MAPK signaling pathway" EXACT [] +synonym: "regulation of stress-activated MAPK signalling pathway" EXACT [] +synonym: "regulation of stress-activated MAPKKK cascade" EXACT [] +synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT [] +is_a: GO:0043408 ! regulation of MAPKKK cascade +relationship: regulates GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0032873 +name: negative regulation of stress-activated MAPK cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] +synonym: "down regulation of stress-activated MAPK cascade" EXACT [] +synonym: "down-regulation of stress-activated MAPK cascade" EXACT [] +synonym: "downregulation of stress-activated MAPK cascade" EXACT [] +synonym: "inhibition of stress-activated MAPK cascade" NARROW [] +synonym: "negative regulation of p38 MAPK signaling" EXACT [] +synonym: "negative regulation of p38 MAPK signalling" EXACT [] +synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT [] +synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT [] +synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT [] +synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT [] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +is_a: GO:0043409 ! negative regulation of MAPKKK cascade +relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0032874 +name: positive regulation of stress-activated MAPK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] +synonym: "activation of stress-activated MAPK cascade" NARROW [] +synonym: "positive regulation of p38 MAPK signaling" EXACT [] +synonym: "positive regulation of p38 MAPK signalling" EXACT [] +synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT [] +synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT [] +synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT [] +synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT [] +synonym: "stimulation of stress-activated MAPK cascade" NARROW [] +synonym: "up regulation of stress-activated MAPK cascade" EXACT [] +synonym: "up-regulation of stress-activated MAPK cascade" EXACT [] +synonym: "upregulation of stress-activated MAPK cascade" EXACT [] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +is_a: GO:0043410 ! positive regulation of MAPKKK cascade +relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0032875 +name: regulation of DNA endoreduplication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah] +synonym: "regulation of DNA endoreplication" EXACT [] +synonym: "regulation of DNA re-duplication" EXACT [] +is_a: GO:0006275 ! regulation of DNA replication +relationship: regulates GO:0042023 ! DNA endoreduplication + +[Term] +id: GO:0032876 +name: negative regulation of DNA endoreduplication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah] +synonym: "down regulation of DNA endoreduplication" EXACT [] +synonym: "down-regulation of DNA endoreduplication" EXACT [] +synonym: "downregulation of DNA endoreduplication" EXACT [] +synonym: "inhibition of DNA endoreduplication" NARROW [] +synonym: "negative regulation of DNA endoreplication" EXACT [] +synonym: "negative regulation of DNA re-duplication" EXACT [] +is_a: GO:0008156 ! negative regulation of DNA replication +is_a: GO:0032875 ! regulation of DNA endoreduplication +relationship: negatively_regulates GO:0042023 ! DNA endoreduplication + +[Term] +id: GO:0032877 +name: positive regulation of DNA endoreduplication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] +synonym: "activation of DNA endoreduplication" NARROW [] +synonym: "positive regulation of DNA endoreplication" EXACT [] +synonym: "positive regulation of DNA re-duplication" EXACT [] +synonym: "stimulation of DNA endoreduplication" NARROW [] +synonym: "up regulation of DNA endoreduplication" EXACT [] +synonym: "up-regulation of DNA endoreduplication" EXACT [] +synonym: "upregulation of DNA endoreduplication" EXACT [] +is_a: GO:0032875 ! regulation of DNA endoreduplication +is_a: GO:0045740 ! positive regulation of DNA replication +relationship: positively_regulates GO:0042023 ! DNA endoreduplication + +[Term] +id: GO:0032878 +name: regulation of establishment or maintenance of cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +is_a: GO:0022604 ! regulation of cell morphogenesis +relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0032879 +name: regulation of localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0051179 ! localization + +[Term] +id: GO:0032880 +name: regulation of protein localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any process by which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] +subset: gosubset_prok +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0008104 ! protein localization + +[Term] +id: GO:0032881 +name: regulation of polysaccharide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] +subset: gosubset_prok +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0032882 +name: regulation of chitin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah] +synonym: "regulation of chitin metabolism" EXACT [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0033238 ! regulation of amine metabolic process +relationship: regulates GO:0006030 ! chitin metabolic process + +[Term] +id: GO:0032883 +name: regulation of chitin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah] +synonym: "regulation of chitin anabolism" EXACT [] +synonym: "regulation of chitin biosynthesis" RELATED [] +synonym: "regulation of chitin formation" EXACT [] +synonym: "regulation of chitin synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032882 ! regulation of chitin metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +relationship: regulates GO:0006031 ! chitin biosynthetic process + +[Term] +id: GO:0032884 +name: regulation of cell wall chitin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah] +synonym: "regulation of cell wall chitin anabolism" EXACT [] +synonym: "regulation of cell wall chitin biosynthesis" EXACT [] +synonym: "regulation of cell wall chitin formation" EXACT [] +synonym: "regulation of cell wall chitin synthesis" EXACT [] +is_a: GO:0032883 ! regulation of chitin biosynthetic process +is_a: GO:0034222 ! regulation of cell wall chitin metabolic process +relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process + +[Term] +id: GO:0032885 +name: regulation of polysaccharide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] +subset: gosubset_prok +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0000271 ! polysaccharide biosynthetic process + +[Term] +id: GO:0032886 +name: regulation of microtubule-based process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: regulates GO:0007017 ! microtubule-based process + +[Term] +id: GO:0032887 +name: regulation of spindle elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0051231 ! spindle elongation + +[Term] +id: GO:0032888 +name: regulation of mitotic spindle elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the mitotic spindle." [GOC:mah] +is_a: GO:0032887 ! regulation of spindle elongation +is_a: GO:0060236 ! regulation of mitotic spindle organization +relationship: regulates GO:0000022 ! mitotic spindle elongation + +[Term] +id: GO:0032889 +name: regulation of vacuole fusion, non-autophagic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic + +[Term] +id: GO:0032890 +name: regulation of organic acid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of, within or between cells." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015849 ! organic acid transport + +[Term] +id: GO:0032891 +name: negative regulation of organic acid transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of organic acids into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of organic acid transport" EXACT [] +synonym: "down-regulation of organic acid transport" EXACT [] +synonym: "downregulation of organic acid transport" EXACT [] +synonym: "inhibition of organic acid transport" NARROW [] +is_a: GO:0032890 ! regulation of organic acid transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0015849 ! organic acid transport + +[Term] +id: GO:0032892 +name: positive regulation of organic acid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of, within or between cells." [GOC:mah] +synonym: "activation of organic acid transport" NARROW [] +synonym: "stimulation of organic acid transport" NARROW [] +synonym: "up regulation of organic acid transport" EXACT [] +synonym: "up-regulation of organic acid transport" EXACT [] +synonym: "upregulation of organic acid transport" EXACT [] +is_a: GO:0032890 ! regulation of organic acid transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0015849 ! organic acid transport + +[Term] +id: GO:0032893 +name: regulation of gluconate transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of gluconate into, out of, within or between cells." [GOC:mah] +is_a: GO:0032890 ! regulation of organic acid transport +relationship: regulates GO:0015725 ! gluconate transport + +[Term] +id: GO:0032894 +name: negative regulation of gluconate transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of gluconate into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of gluconate transport" EXACT [] +synonym: "down-regulation of gluconate transport" EXACT [] +synonym: "downregulation of gluconate transport" EXACT [] +synonym: "inhibition of gluconate transport" NARROW [] +is_a: GO:0032891 ! negative regulation of organic acid transport +is_a: GO:0032893 ! regulation of gluconate transport +relationship: negatively_regulates GO:0015725 ! gluconate transport + +[Term] +id: GO:0032895 +name: positive regulation of gluconate transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate into, out of, within or between cells." [GOC:mah] +synonym: "activation of gluconate transport" NARROW [] +synonym: "induction of gluconate transport" NARROW [] +synonym: "stimulation of gluconate transport" NARROW [] +synonym: "up regulation of gluconate transport" EXACT [] +synonym: "up-regulation of gluconate transport" EXACT [] +synonym: "upregulation of gluconate transport" EXACT [] +is_a: GO:0032892 ! positive regulation of organic acid transport +is_a: GO:0032893 ! regulation of gluconate transport +relationship: positively_regulates GO:0015725 ! gluconate transport + +[Term] +id: GO:0032896 +name: palmitoyl-CoA 9-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv] +synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT [] +is_a: GO:0016215 ! CoA desaturase activity + +[Term] +id: GO:0032897 +name: negative regulation of viral transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral transcription." [GOC:mah] +synonym: "down regulation of viral transcription" EXACT [] +synonym: "down-regulation of viral transcription" EXACT [] +synonym: "downregulation of viral transcription" EXACT [] +synonym: "inhibition of viral transcription" NARROW [] +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +is_a: GO:0046782 ! regulation of viral transcription +is_a: GO:0048524 ! positive regulation of viral reproduction +relationship: negatively_regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0032898 +name: neurotrophin production +namespace: biological_process +def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0043524 ! negative regulation of neuron apoptosis + +[Term] +id: GO:0032899 +name: regulation of neurotrophin production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032900 +name: negative regulation of neurotrophin production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] +synonym: "down regulation of neurotrophin production" EXACT [] +synonym: "down-regulation of neurotrophin production" EXACT [] +synonym: "downregulation of neurotrophin production" EXACT [] +synonym: "inhibition of neurotrophin production" NARROW [] +is_a: GO:0032899 ! regulation of neurotrophin production +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032901 +name: positive regulation of neurotrophin production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] +synonym: "activation of neurotrophin production" NARROW [] +synonym: "stimulation of neurotrophin production" NARROW [] +synonym: "up regulation of neurotrophin production" EXACT [] +synonym: "up-regulation of neurotrophin production" EXACT [] +synonym: "upregulation of neurotrophin production" EXACT [] +is_a: GO:0032899 ! regulation of neurotrophin production +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032902 +name: nerve growth factor production +namespace: biological_process +def: "The appearance of nerve growth factor due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah] +synonym: "NGF production" EXACT [] +is_a: GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032903 +name: regulation of nerve growth factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor." [GOC:mah] +synonym: "regulation of NGF production" EXACT [] +is_a: GO:0032899 ! regulation of neurotrophin production +relationship: regulates GO:0032902 ! nerve growth factor production + +[Term] +id: GO:0032904 +name: negative regulation of nerve growth factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor." [GOC:mah] +synonym: "down regulation of nerve growth factor production" EXACT [] +synonym: "down-regulation of nerve growth factor production" EXACT [] +synonym: "downregulation of nerve growth factor production" EXACT [] +synonym: "inhibition of nerve growth factor production" NARROW [] +synonym: "negative regulation of NGF production" EXACT [] +is_a: GO:0032900 ! negative regulation of neurotrophin production +is_a: GO:0032903 ! regulation of nerve growth factor production +relationship: negatively_regulates GO:0032902 ! nerve growth factor production + +[Term] +id: GO:0032905 +name: transforming growth factor-beta1 production +namespace: biological_process +def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "TGF-B1 production" EXACT [] +synonym: "TGFB1 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032906 +name: transforming growth factor-beta2 production +namespace: biological_process +def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "TGF-B2 production" EXACT [] +synonym: "TGFB2 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032907 +name: transforming growth factor-beta3 production +namespace: biological_process +def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "TGF-B3 production" EXACT [] +synonym: "TGFB3 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032908 +name: regulation of transforming growth factor-beta1 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] +synonym: "regulation of TGF-B1 production" EXACT [] +synonym: "regulation of TGFB1 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032905 ! transforming growth factor-beta1 production + +[Term] +id: GO:0032909 +name: regulation of transforming growth factor-beta2 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] +synonym: "regulation of TGF-B2 production" EXACT [] +synonym: "regulation of TGFB2 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032906 ! transforming growth factor-beta2 production + +[Term] +id: GO:0032910 +name: regulation of transforming growth factor-beta3 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] +synonym: "regulation of TGF-B3 production" EXACT [] +synonym: "regulation of TGFB3 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032907 ! transforming growth factor-beta3 production + +[Term] +id: GO:0032911 +name: negative regulation of transforming growth factor-beta1 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] +synonym: "down regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "down-regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "downregulation of transforming growth factor-beta1 production" EXACT [] +synonym: "inhibition of transforming growth factor-beta1 production" NARROW [] +synonym: "negative regulation of TGF-B1 production" EXACT [] +synonym: "negative regulation of TGFB1 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032908 ! regulation of transforming growth factor-beta1 production +relationship: negatively_regulates GO:0032905 ! transforming growth factor-beta1 production + +[Term] +id: GO:0032912 +name: negative regulation of transforming growth factor-beta2 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] +synonym: "down regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "down-regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "downregulation of transforming growth factor-beta2 production" EXACT [] +synonym: "inhibition of transforming growth factor-beta2 production" NARROW [] +synonym: "negative regulation of TGF-B2 production" EXACT [] +synonym: "negative regulation of TGFB2 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032909 ! regulation of transforming growth factor-beta2 production +relationship: negatively_regulates GO:0032906 ! transforming growth factor-beta2 production + +[Term] +id: GO:0032913 +name: negative regulation of transforming growth factor-beta3 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] +synonym: "down regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "down-regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "downregulation of transforming growth factor-beta3 production" EXACT [] +synonym: "inhibition of transforming growth factor-beta3 production" NARROW [] +synonym: "negative regulation of TGF-B3 production" EXACT [] +synonym: "negative regulation of TGFB3 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032910 ! regulation of transforming growth factor-beta3 production +relationship: negatively_regulates GO:0032907 ! transforming growth factor-beta3 production + +[Term] +id: GO:0032914 +name: positive regulation of transforming growth factor-beta1 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] +synonym: "activation of transforming growth factor-beta1 production" NARROW [] +synonym: "positive regulation of TGF-B1 production" EXACT [] +synonym: "positive regulation of TGFB1 production" EXACT [] +synonym: "stimulation of transforming growth factor-beta1 production" NARROW [] +synonym: "up regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "up-regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "upregulation of transforming growth factor-beta1 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032908 ! regulation of transforming growth factor-beta1 production +relationship: positively_regulates GO:0032905 ! transforming growth factor-beta1 production + +[Term] +id: GO:0032915 +name: positive regulation of transforming growth factor-beta2 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] +synonym: "activation of transforming growth factor-beta2 production" NARROW [] +synonym: "positive regulation of TGF-B2 production" EXACT [] +synonym: "positive regulation of TGFB2 production" EXACT [] +synonym: "stimulation of transforming growth factor-beta2 production" NARROW [] +synonym: "up regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "up-regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "upregulation of transforming growth factor-beta2 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032909 ! regulation of transforming growth factor-beta2 production +relationship: positively_regulates GO:0032906 ! transforming growth factor-beta2 production + +[Term] +id: GO:0032916 +name: positive regulation of transforming growth factor-beta3 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] +synonym: "activation of transforming growth factor-beta3 production" NARROW [] +synonym: "positive regulation of TGF-B3 production" EXACT [] +synonym: "positive regulation of TGFB3 production" EXACT [] +synonym: "stimulation of transforming growth factor-beta3 production" NARROW [] +synonym: "up regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "up-regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "upregulation of transforming growth factor-beta3 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032910 ! regulation of transforming growth factor-beta3 production +relationship: positively_regulates GO:0032907 ! transforming growth factor-beta3 production + +[Term] +id: GO:0032917 +name: polyamine acetylation +namespace: biological_process +def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0032918 +name: spermidine acetylation +namespace: biological_process +def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg] +is_a: GO:0008216 ! spermidine metabolic process +is_a: GO:0032917 ! polyamine acetylation + +[Term] +id: GO:0032919 +name: spermine acetylation +namespace: biological_process +def: "The modification of spermine by addition of acetyl groups." [GOC:mlg] +is_a: GO:0008215 ! spermine metabolic process +is_a: GO:0032917 ! polyamine acetylation + +[Term] +id: GO:0032920 +name: putrescine acetylation +namespace: biological_process +def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg] +is_a: GO:0009445 ! putrescine metabolic process +is_a: GO:0032917 ! polyamine acetylation + +[Term] +id: GO:0032921 +name: sarcosine oxidase complex +namespace: cellular_component +def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0032922 +name: circadian regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] +synonym: "circadian regulation of protein expression" RELATED [] +synonym: "diurnal variation of gene expression" RELATED [] +synonym: "diurnal variation of protein expression" RELATED [] +is_a: GO:0007623 ! circadian rhythm +is_a: GO:0010468 ! regulation of gene expression + +[Term] +id: GO:0032923 +name: phosphonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] +is_a: GO:0019634 ! phosphonate metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0032924 +name: activin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor." [GOC:rl] +synonym: "activin receptor signalling pathway" EXACT [] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0032925 +name: regulation of activin receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl] +synonym: "regulation of activin receptor signalling pathway" EXACT [] +synonym: "regulation of activin signaling pathway" RELATED [] +synonym: "regulation of activin signalling pathway" RELATED [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0032926 +name: negative regulation of activin receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl] +synonym: "down regulation of activin receptor signaling pathway" EXACT [] +synonym: "down-regulation of activin receptor signaling pathway" EXACT [] +synonym: "downregulation of activin receptor signaling pathway" EXACT [] +synonym: "inhibition of activin receptor signaling pathway" NARROW [] +synonym: "negative regulation of activin receptor signalling pathway" EXACT [] +synonym: "negative regulation of activin signaling pathway" RELATED [] +synonym: "negative regulation of activin signalling pathway" RELATED [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0032925 ! regulation of activin receptor signaling pathway +relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0032927 +name: positive regulation of activin receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl] +synonym: "activation of activin receptor signaling pathway" NARROW [] +synonym: "positive regulation of activin receptor signalling pathway" EXACT [] +synonym: "positive regulation of activin signaling pathway" RELATED [] +synonym: "positive regulation of activin signalling pathway" RELATED [] +synonym: "stimulation of activin receptor signaling pathway" NARROW [] +synonym: "up regulation of activin receptor signaling pathway" EXACT [] +synonym: "up-regulation of activin receptor signaling pathway" EXACT [] +synonym: "upregulation of activin receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0032925 ! regulation of activin receptor signaling pathway +relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0032928 +name: regulation of superoxide release +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] +is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process +relationship: regulates GO:0042554 ! superoxide release + +[Term] +id: GO:0032929 +name: negative regulation of superoxide release +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] +synonym: "down regulation of superoxide release" EXACT [] +synonym: "down-regulation of superoxide release" EXACT [] +synonym: "downregulation of superoxide release" EXACT [] +synonym: "inhibition of superoxide release" NARROW [] +is_a: GO:0010671 ! negative regulation of oxygen and reactive oxygen species metabolic process +is_a: GO:0032928 ! regulation of superoxide release +relationship: negatively_regulates GO:0042554 ! superoxide release + +[Term] +id: GO:0032930 +name: positive regulation of superoxide release +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] +synonym: "activation of superoxide release" NARROW [] +synonym: "stimulation of superoxide release" NARROW [] +synonym: "up regulation of superoxide release" EXACT [] +synonym: "up-regulation of superoxide release" EXACT [] +synonym: "upregulation of superoxide release" EXACT [] +is_a: GO:0010670 ! positive regulation of oxygen and reactive oxygen species metabolic process +is_a: GO:0032928 ! regulation of superoxide release +relationship: positively_regulates GO:0042554 ! superoxide release + +[Term] +id: GO:0032931 +name: histone lysine N-acetyltransferase activity (H3-K56 specific) +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group onto lysine at position 56 of the histone H3 protein." [GOC:mah] +is_a: GO:0004406 ! H3/H4 histone acetyltransferase activity + +[Term] +id: GO:0032932 +name: negative regulation of spindle astral microtubule depolymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah] +synonym: "astral microtubule stabilization" EXACT [] +is_a: GO:0007026 ! negative regulation of microtubule depolymerization +relationship: negatively_regulates GO:0060172 ! spindle astral microtubule depolymerization + +[Term] +id: GO:0032933 +name: SREBP-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP." [GOC:mah, PMID:12923525] +synonym: "SREBP-mediated signalling pathway" EXACT [] +is_a: GO:0006984 ! ER-nuclear signaling pathway + +[Term] +id: GO:0032934 +name: sterol binding +namespace: molecular_function +def: "Interacting selectively with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [ChEBI:15889, GOC:mah] +subset: gosubset_prok +is_a: GO:0005496 ! steroid binding + +[Term] +id: GO:0032935 +name: sterol sensor activity +namespace: molecular_function +def: "Interacting selectively with and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah] +synonym: "sterol-sensing domain" NARROW [] +is_a: GO:0032934 ! sterol binding + +[Term] +id: GO:0032936 +name: SREBP-SCAP complex +namespace: cellular_component +def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525] +synonym: "Sre1-Scp1 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0032937 +name: SREBP-SCAP-Insig complex +namespace: cellular_component +def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane." [PMID:12923525] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane + +[Term] +id: GO:0032938 +name: negative regulation of translation in response to oxidative stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0043556 ! regulation of translation in response to oxidative stress + +[Term] +id: GO:0032939 +name: positive regulation of translation in response to oxidative stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] +synonym: "activation of translation in response to oxidative stress" NARROW [] +synonym: "stimulation of translation in response to oxidative stress" NARROW [] +synonym: "up regulation of translation in response to oxidative stress" EXACT [] +synonym: "up-regulation of translation in response to oxidative stress" EXACT [] +synonym: "upregulation of translation in response to oxidative stress" EXACT [] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0043556 ! regulation of translation in response to oxidative stress + +[Term] +id: GO:0032940 +name: secretion by cell +namespace: biological_process +def: "The regulated release of a substance by a cell." [GOC:mah] +synonym: "cellular secretion" EXACT [] +is_a: GO:0046903 ! secretion +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0032941 +name: secretion by tissue +namespace: biological_process +def: "The regulated release of a substance by a tissue." [GOC:mah] +synonym: "tissue secretion" EXACT [] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0032942 +name: inositol tetrakisphosphate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf] +synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT [] +synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT [] +synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT [] +xref: EC:2.7.1.- +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0032943 +name: mononuclear cell proliferation +namespace: biological_process +def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] +synonym: "PBMC proliferation" NARROW [] +synonym: "peripheral blood mononuclear cell proliferation" NARROW [] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0032944 +name: regulation of mononuclear cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] +synonym: "regulation of PBMC proliferation" NARROW [] +synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0032943 ! mononuclear cell proliferation + +[Term] +id: GO:0032945 +name: negative regulation of mononuclear cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] +synonym: "negative regulation of PBMC proliferation" NARROW [] +synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0032944 ! regulation of mononuclear cell proliferation +relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation + +[Term] +id: GO:0032946 +name: positive regulation of mononuclear cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] +synonym: "activation of mononuclear cell proliferation" NARROW [] +synonym: "positive regulation of PBMC proliferation" NARROW [] +synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] +synonym: "stimulation of mononuclear cell proliferation" NARROW [] +synonym: "up regulation of mononuclear cell proliferation" EXACT [] +synonym: "up-regulation of mononuclear cell proliferation" EXACT [] +synonym: "upregulation of mononuclear cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0032944 ! regulation of mononuclear cell proliferation +relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation + +[Term] +id: GO:0032947 +name: protein complex scaffold +namespace: molecular_function +def: "Functions to provide a physical support for the assembly of a multiprotein complex." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032948 +name: regulation of alpha-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of alpha-glucan metabolism" EXACT [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0032949 +name: regulation of alpha-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah] +synonym: "regulation of alpha-glucan anabolism" EXACT [] +synonym: "regulation of alpha-glucan biosynthesis" EXACT [] +synonym: "regulation of alpha-glucan formation" EXACT [] +synonym: "regulation of alpha-glucan synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:0032948 ! regulation of alpha-glucan metabolic process +is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis +relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process + +[Term] +id: GO:0032950 +name: regulation of beta-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of beta-glucan metabolism" EXACT [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0032951 +name: regulation of beta-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah] +synonym: "regulation of beta-glucan anabolism" EXACT [] +synonym: "regulation of beta-glucan biosynthesis" EXACT [] +synonym: "regulation of beta-glucan formation" EXACT [] +synonym: "regulation of beta-glucan synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:0032950 ! regulation of beta-glucan metabolic process +relationship: regulates GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0032952 +name: regulation of 1,3-beta-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-1,3 glucans." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of 1,3-beta-glucan metabolism" EXACT [] +is_a: GO:0032950 ! regulation of beta-glucan metabolic process +relationship: regulates GO:0006074 ! 1,3-beta-glucan metabolic process + +[Term] +id: GO:0032953 +name: regulation of 1,3-beta-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-1,3 glucans." [GOC:mah] +synonym: "regulation of 1,3-beta-glucan anabolism" EXACT [] +synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT [] +synonym: "regulation of 1,3-beta-glucan formation" EXACT [] +synonym: "regulation of 1,3-beta-glucan synthesis" EXACT [] +is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process +is_a: GO:0032952 ! regulation of 1,3-beta-glucan metabolic process +is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis +relationship: regulates GO:0006075 ! 1,3-beta-glucan biosynthetic process + +[Term] +id: GO:0032954 +name: regulation of cytokinetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah] +subset: gosubset_prok +is_a: GO:0032465 ! regulation of cytokinesis +relationship: regulates GO:0032506 ! cytokinetic process + +[Term] +id: GO:0032955 +name: regulation of barrier septum formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of barrier septum formation." [GOC:mah] +is_a: GO:0032954 ! regulation of cytokinetic process +relationship: regulates GO:0000917 ! barrier septum formation + +[Term] +id: GO:0032956 +name: regulation of actin cytoskeleton organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] +synonym: "regulation of actin cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0032970 ! regulation of actin filament-based process +relationship: regulates GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0032957 +name: inositol trisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [ChEBI:24540, ChEBI:24848, GOC:mah] +synonym: "inositol trisphosphate metabolism" EXACT [] +synonym: "IP3 metabolic process" EXACT [] +synonym: "IP3 metabolism" EXACT [] +synonym: "myo-inositol trisphosphate metabolic process" NARROW [] +is_a: GO:0043647 ! inositol phosphate metabolic process + +[Term] +id: GO:0032958 +name: inositol phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [ChEBI:24848, ChEBI:25448, GOC:mah] +comment: See also the biological process term 'inositol and derivative phosphorylation ; GO:0046853'. +synonym: "inositol phosphate anabolism" EXACT [] +synonym: "inositol phosphate biosynthesis" EXACT [] +synonym: "inositol phosphate formation" EXACT [] +synonym: "inositol phosphate synthesis" EXACT [] +synonym: "myo-inositol phosphate biosynthetic process" NARROW [] +is_a: GO:0006021 ! inositol biosynthetic process +is_a: GO:0043647 ! inositol phosphate metabolic process + +[Term] +id: GO:0032959 +name: inositol trisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [ChEBI:24848, ChEBI:25450, GOC:mah] +synonym: "inositol trisphosphate anabolism" EXACT [] +synonym: "inositol trisphosphate biosynthesis" EXACT [] +synonym: "inositol trisphosphate formation" EXACT [] +synonym: "inositol trisphosphate synthesis" EXACT [] +synonym: "IP3 biosynthesis" EXACT [] +synonym: "IP3 biosynthetic process" EXACT [] +synonym: "myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0032957 ! inositol trisphosphate metabolic process +is_a: GO:0032958 ! inositol phosphate biosynthetic process + +[Term] +id: GO:0032960 +name: regulation of inositol trisphosphate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] +synonym: "regulation of inositol trisphosphate anabolism" EXACT [] +synonym: "regulation of inositol trisphosphate biosynthesis" EXACT [] +synonym: "regulation of inositol trisphosphate formation" EXACT [] +synonym: "regulation of inositol trisphosphate synthesis" EXACT [] +synonym: "regulation of IP3 biosynthesis" EXACT [] +synonym: "regulation of IP3 biosynthetic process" EXACT [] +synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW [] +synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process + +[Term] +id: GO:0032961 +name: negative regulation of inositol trisphosphate biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] +synonym: "negative regulation of inositol trisphosphate anabolism" EXACT [] +synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT [] +synonym: "negative regulation of inositol trisphosphate formation" EXACT [] +synonym: "negative regulation of inositol trisphosphate synthesis" EXACT [] +synonym: "negative regulation of IP3 biosynthesis" EXACT [] +synonym: "negative regulation of IP3 biosynthetic process" EXACT [] +synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW [] +synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process + +[Term] +id: GO:0032962 +name: positive regulation of inositol trisphosphate biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] +synonym: "positive regulation of inositol trisphosphate anabolism" EXACT [] +synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT [] +synonym: "positive regulation of inositol trisphosphate formation" EXACT [] +synonym: "positive regulation of inositol trisphosphate synthesis" EXACT [] +synonym: "positive regulation of IP3 biosynthesis" EXACT [] +synonym: "positive regulation of IP3 biosynthetic process" EXACT [] +synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW [] +synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process + +[Term] +id: GO:0032963 +name: collagen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "collagen metabolism" EXACT [] +is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process + +[Term] +id: GO:0032964 +name: collagen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "collagen anabolism" EXACT [] +synonym: "collagen biosynthesis" EXACT [] +synonym: "collagen formation" EXACT [] +synonym: "collagen synthesis" EXACT [] +is_a: GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0032965 +name: regulation of collagen biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] +synonym: "regulation of collagen anabolism" EXACT [] +synonym: "regulation of collagen biosynthesis" EXACT [] +synonym: "regulation of collagen formation" EXACT [] +synonym: "regulation of collagen synthesis" EXACT [] +is_a: GO:0010712 ! regulation of collagen metabolic process +relationship: regulates GO:0032964 ! collagen biosynthetic process + +[Term] +id: GO:0032966 +name: negative regulation of collagen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] +synonym: "negative regulation of collagen anabolism" EXACT [] +synonym: "negative regulation of collagen biosynthesis" EXACT [] +synonym: "negative regulation of collagen formation" EXACT [] +synonym: "negative regulation of collagen synthesis" EXACT [] +is_a: GO:0010713 ! negative regulation of collagen metabolic process +is_a: GO:0032965 ! regulation of collagen biosynthetic process +relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process + +[Term] +id: GO:0032967 +name: positive regulation of collagen biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] +synonym: "positive regulation of collagen anabolism" EXACT [] +synonym: "positive regulation of collagen biosynthesis" EXACT [] +synonym: "positive regulation of collagen formation" EXACT [] +synonym: "positive regulation of collagen synthesis" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010714 ! positive regulation of collagen metabolic process +is_a: GO:0032965 ! regulation of collagen biosynthetic process +relationship: positively_regulates GO:0032964 ! collagen biosynthetic process + +[Term] +id: GO:0032968 +name: positive regulation of RNA elongation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah] +synonym: "positive regulation of transcription elongation from RNA polymerase II promoter" BROAD [] +is_a: GO:0032786 ! positive regulation of RNA elongation +is_a: GO:0034243 ! regulation of RNA elongation from RNA polymerase II promoter +relationship: positively_regulates GO:0006368 ! RNA elongation from RNA polymerase II promoter + +[Term] +id: GO:0032969 +name: endosomal scaffold complex +namespace: cellular_component +def: "A complex in eukaryotic cells containing Mapbpip (p14,Rab25) and Map2k1ip1 (MP1). The complex anchors on late endosomes and is involved in activating ERK 1/2, key components in MAPK signaling." [PMID:15263099] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0031902 ! late endosome membrane + +[Term] +id: GO:0032970 +name: regulation of actin filament-based process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: regulates GO:0030029 ! actin filament-based process + +[Term] +id: GO:0032971 +name: regulation of muscle filament sliding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd] +is_a: GO:0006937 ! regulation of muscle contraction +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0032970 ! regulation of actin filament-based process +relationship: regulates GO:0030049 ! muscle filament sliding + +[Term] +id: GO:0032972 +name: regulation of muscle filament sliding speed +namespace: biological_process +def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb] +is_a: GO:0032971 ! regulation of muscle filament sliding +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0032973 +name: amino acid export +namespace: biological_process +def: "The directed movement of amino acids out of a cell or organelle." [GOC:mah] +synonym: "amino acid efflux" EXACT [] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0032974 +name: amino acid export from vacuole +namespace: biological_process +def: "The directed movement of amino acids out of the vacuole." [GOC:mah] +synonym: "amino acid efflux from vacuole" EXACT [] +synonym: "vacuolar amino acid export" EXACT [] +is_a: GO:0032973 ! amino acid export +is_a: GO:0034487 ! vacuolar amino acid transport + +[Term] +id: GO:0032975 +name: amino acid import into vacuole +namespace: biological_process +def: "The directed movement of amino acids into the vacuole." [GOC:mah] +synonym: "vacuolar amino acid import" EXACT [] +is_a: GO:0034487 ! vacuolar amino acid transport +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0032976 +name: release of matrix enzymes from mitochondria +namespace: biological_process +def: "The process by which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol." [GOC:mah, PMID:9843949] +synonym: "mAST release from mitochondria" NARROW [] +synonym: "release of aspartate aminotransferase from mitochondria" NARROW [] +is_a: GO:0008637 ! apoptotic mitochondrial changes + +[Term] +id: GO:0032977 +name: membrane insertase activity +namespace: molecular_function +def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936] +subset: gosubset_prok +is_a: GO:0008565 ! protein transporter activity + +[Term] +id: GO:0032978 +name: protein insertion into membrane from inner side +namespace: biological_process +def: "The process by which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843] +synonym: "insertion of proteins into membrane from the inner side" EXACT [] +is_a: GO:0051205 ! protein insertion into membrane + +[Term] +id: GO:0032979 +name: protein insertion into mitochondrial membrane from inner side +namespace: biological_process +def: "The process by which a protein is incorporated into the mitochondrial membrane from the inner side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [PMID:12880202, PMID:15473843] +synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT [] +is_a: GO:0032978 ! protein insertion into membrane from inner side +is_a: GO:0051204 ! protein insertion into mitochondrial membrane + +[Term] +id: GO:0032980 +name: keratinocyte activation +namespace: biological_process +def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0032981 +name: mitochondrial respiratory chain complex I assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rh] +synonym: "mitochondrial complex I assembly" EXACT [] +synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT [] +is_a: GO:0010257 ! NADH dehydrogenase complex assembly +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly + +[Term] +id: GO:0032982 +name: myosin filament +namespace: cellular_component +def: "A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] +synonym: "myosin thick filament" RELATED [] +synonym: "thick filament" RELATED [] +is_a: GO:0016459 ! myosin complex + +[Term] +id: GO:0032983 +name: kainate selective glutamate receptor complex +namespace: cellular_component +def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluR5-7 and KA-1/2 subunits." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] +is_a: GO:0008328 ! ionotropic glutamate receptor complex + +[Term] +id: GO:0032984 +name: macromolecular complex disassembly +namespace: biological_process +def: "The disaggregation of a macromolecular complex into its constituent components." [GOC:mah] +subset: gosubset_prok +synonym: "macromolecule complex disassembly" EXACT [] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0043933 ! macromolecular complex subunit organization + +[Term] +id: GO:0032985 +name: protein-carbohydrate complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah] +is_a: GO:0032984 ! macromolecular complex disassembly + +[Term] +id: GO:0032986 +name: protein-DNA complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] +is_a: GO:0034623 ! cellular macromolecular complex disassembly + +[Term] +id: GO:0032987 +name: protein-lipid complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah] +is_a: GO:0032984 ! macromolecular complex disassembly + +[Term] +id: GO:0032988 +name: ribonucleoprotein complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] +synonym: "protein-RNA complex disassembly" EXACT [] +synonym: "RNA-protein complex disassembly" EXACT [] +synonym: "RNP complex disassembly" EXACT [] +is_a: GO:0034623 ! cellular macromolecular complex disassembly + +[Term] +id: GO:0032989 +name: cellular structure morphogenesis +namespace: biological_process +def: "The process by which cellular structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0016043 ! cellular component organization +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0032990 +name: cell part morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mah] +is_a: GO:0032989 ! cellular structure morphogenesis + +[Term] +id: GO:0032991 +name: macromolecular complex +namespace: cellular_component +def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "macromolecule complex" EXACT [] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0032992 +name: protein-carbohydrate complex +namespace: cellular_component +def: "A macromolecular complex containing both protein and carbohydrate molecules." [GOC:mah] +subset: gosubset_prok +is_a: GO:0032991 ! macromolecular complex + +[Term] +id: GO:0032993 +name: protein-DNA complex +namespace: cellular_component +def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] +subset: gosubset_prok +is_a: GO:0032991 ! macromolecular complex + +[Term] +id: GO:0032994 +name: protein-lipid complex +namespace: cellular_component +def: "A macromolecular complex containing both protein and lipid molecules." [GOC:mah] +subset: gosubset_prok +is_a: GO:0032991 ! macromolecular complex + +[Term] +id: GO:0032995 +name: regulation of fungal-type cell wall biogenesis +namespace: biological_process +def: "Any process that modulates the chemical reactions and pathways resulting in the formation of the fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" EXACT [] +is_a: GO:0060237 ! regulation of fungal-type cell wall organization +relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0032996 +name: Bcl3-Bcl10 complex +namespace: cellular_component +def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0032997 +name: Fc receptor complex +namespace: cellular_component +def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +subset: goslim_pir +synonym: "Fc-receptor complex" EXACT [] +synonym: "FcR complex" EXACT [] +synonym: "immunoglobulin receptor complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0032998 +name: Fc-epsilon receptor I complex +namespace: cellular_component +def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "FceRI complex" EXACT [] +synonym: "IgE receptor complex" BROAD [] +synonym: "immunoglobulin E receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0032999 +name: Fc-alpha receptor I complex +namespace: cellular_component +def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12524384] +synonym: "FcaRI complex" EXACT [] +synonym: "IgA receptor complex" BROAD [] +synonym: "immunoglobulin A receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0033000 +name: Fc-gamma receptor I complex +namespace: cellular_component +def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532] +synonym: "FcgRI complex" EXACT [] +synonym: "IgG receptor complex" BROAD [] +synonym: "immunoglobulin G receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0033001 +name: Fc-gamma receptor III complex +namespace: cellular_component +def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532] +synonym: "FcgRIII complex" EXACT [] +synonym: "IgG receptor complex" BROAD [] +synonym: "immunoglobulin G receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0033002 +name: muscle cell proliferation +namespace: biological_process +def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] +synonym: "myocyte proliferation" EXACT [] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0033003 +name: regulation of mast cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0045576 ! mast cell activation + +[Term] +id: GO:0033004 +name: negative regulation of mast cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0033003 ! regulation of mast cell activation +relationship: negatively_regulates GO:0045576 ! mast cell activation + +[Term] +id: GO:0033005 +name: positive regulation of mast cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0033003 ! regulation of mast cell activation +relationship: positively_regulates GO:0045576 ! mast cell activation + +[Term] +id: GO:0033006 +name: regulation of mast cell activation during immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell activation during an immune response." [GOC:mah] +is_a: GO:0033003 ! regulation of mast cell activation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002279 ! mast cell activation during immune response + +[Term] +id: GO:0033007 +name: negative regulation of mast cell activation during immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of mast cell activation during an immune response." [GOC:mah] +is_a: GO:0033004 ! negative regulation of mast cell activation +is_a: GO:0033006 ! regulation of mast cell activation during immune response +relationship: negatively_regulates GO:0002279 ! mast cell activation during immune response + +[Term] +id: GO:0033008 +name: positive regulation of mast cell activation during immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation during an immune response." [GOC:mah] +is_a: GO:0033005 ! positive regulation of mast cell activation +is_a: GO:0033006 ! regulation of mast cell activation during immune response +relationship: positively_regulates GO:0002279 ! mast cell activation during immune response + +[Term] +id: GO:0033009 +name: nucleomorph +namespace: cellular_component +def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0033010 +name: paranodal junction +namespace: cellular_component +def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0033011 +name: perinuclear theca +namespace: cellular_component +def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156] +is_a: GO:0005856 ! cytoskeleton +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0048471 ! perinuclear region of cytoplasm + +[Term] +id: GO:0033012 +name: porosome +namespace: cellular_component +def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0033013 +name: tetrapyrrole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [ChEBI:26932, GOC:mah] +synonym: "tetrapyrrole metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0033014 +name: tetrapyrrole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [ChEBI:26932, GOC:mah] +synonym: "tetrapyrrole anabolism" EXACT [] +synonym: "tetrapyrrole biosynthesis" EXACT [] +synonym: "tetrapyrrole formation" EXACT [] +synonym: "tetrapyrrole synthesis" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0033015 +name: tetrapyrrole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [ChEBI:26932, GOC:mah] +synonym: "tetrapyrrole breakdown" EXACT [] +synonym: "tetrapyrrole catabolism" EXACT [] +synonym: "tetrapyrrole degradation" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0033016 +name: rhoptry membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a rhoptry." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0020008 ! rhoptry + +[Term] +id: GO:0033017 +name: sarcoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] +is_a: GO:0005789 ! endoplasmic reticulum membrane +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0033018 +name: sarcoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0033019 +name: 5-hydroxyvalerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033020 +name: cyclopentanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764] +subset: gosubset_prok +synonym: "cyclopentanol metabolism" EXACT [] +is_a: GO:0034308 ! monohydric alcohol metabolic process + +[Term] +id: GO:0033021 +name: cyclopentanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764] +subset: gosubset_prok +synonym: "cyclopentanol anabolism" EXACT [] +synonym: "cyclopentanol biosynthesis" EXACT [] +synonym: "cyclopentanol formation" EXACT [] +synonym: "cyclopentanol synthesis" EXACT [] +is_a: GO:0033020 ! cyclopentanol metabolic process +is_a: GO:0034309 ! monohydric alcohol biosynthetic process + +[Term] +id: GO:0033022 +name: cyclopentanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764] +subset: gosubset_prok +synonym: "cyclopentanol breakdown" EXACT [] +synonym: "cyclopentanol catabolism" EXACT [] +synonym: "cyclopentanol degradation" EXACT [] +is_a: GO:0033020 ! cyclopentanol metabolic process +is_a: GO:0034310 ! monohydric alcohol catabolic process + +[Term] +id: GO:0033023 +name: mast cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031] +comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0033024 +name: mast cell apoptosis +namespace: biological_process +def: "The process of apoptosis in mast cells." [GOC:add, PMID:11292031, PMID:12360215, PMID:16605130] +synonym: "apoptosis of mast cells" EXACT [] +is_a: GO:0033028 ! myeloid cell apoptosis +relationship: part_of GO:0033023 ! mast cell homeostasis + +[Term] +id: GO:0033025 +name: regulation of mast cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell apoptosis." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0033032 ! regulation of myeloid cell apoptosis +relationship: regulates GO:0033024 ! mast cell apoptosis + +[Term] +id: GO:0033026 +name: negative regulation of mast cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a mast cell apoptosis." [GOC:add] +synonym: "down regulation of mast cell apoptosis" EXACT [] +synonym: "down-regulation of mast cell apoptosis" EXACT [] +synonym: "downregulation of mast cell apoptosis" EXACT [] +synonym: "inhibition of mast cell apoptosis" NARROW [] +is_a: GO:0033025 ! regulation of mast cell apoptosis +is_a: GO:0033033 ! negative regulation of myeloid cell apoptosis +relationship: negatively_regulates GO:0033024 ! mast cell apoptosis + +[Term] +id: GO:0033027 +name: positive regulation of mast cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptosis." [GOC:add] +synonym: "activation of mast cell apoptosis" NARROW [] +synonym: "stimulation of mast cell apoptosis" NARROW [] +synonym: "up regulation of mast cell apoptosis" EXACT [] +synonym: "up-regulation of mast cell apoptosis" EXACT [] +synonym: "upregulation of mast cell apoptosis" EXACT [] +is_a: GO:0033025 ! regulation of mast cell apoptosis +is_a: GO:0033034 ! positive regulation of myeloid cell apoptosis +relationship: positively_regulates GO:0033024 ! mast cell apoptosis + +[Term] +id: GO:0033028 +name: myeloid cell apoptosis +namespace: biological_process +def: "The process of apoptosis in myeloid cells." [GOC:add, PMID:11292031, PMID:15330259, PMID:17133093] +synonym: "apoptosis of myeloid cells" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0033029 +name: regulation of neutrophil apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptosis." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0033032 ! regulation of myeloid cell apoptosis +relationship: regulates GO:0001781 ! neutrophil apoptosis + +[Term] +id: GO:0033030 +name: negative regulation of neutrophil apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a neutrophil apoptosis." [GOC:add] +synonym: "down regulation of neutrophil apoptosis" EXACT [] +synonym: "down-regulation of neutrophil apoptosis" EXACT [] +synonym: "downregulation of neutrophil apoptosis" EXACT [] +synonym: "inhibition of neutrophil apoptosis" NARROW [] +is_a: GO:0033029 ! regulation of neutrophil apoptosis +is_a: GO:0033033 ! negative regulation of myeloid cell apoptosis +relationship: negatively_regulates GO:0001781 ! neutrophil apoptosis + +[Term] +id: GO:0033031 +name: positive regulation of neutrophil apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptosis." [GOC:add] +synonym: "activation of neutrophil apoptosis" NARROW [] +synonym: "stimulation of neutrophil apoptosis" NARROW [] +synonym: "up regulation of neutrophil apoptosis" EXACT [] +synonym: "up-regulation of neutrophil apoptosis" EXACT [] +synonym: "upregulation of neutrophil apoptosis" EXACT [] +is_a: GO:0033029 ! regulation of neutrophil apoptosis +is_a: GO:0033034 ! positive regulation of myeloid cell apoptosis +relationship: positively_regulates GO:0001781 ! neutrophil apoptosis + +[Term] +id: GO:0033032 +name: regulation of myeloid cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptosis." [GOC:add] +is_a: GO:0042981 ! regulation of apoptosis +relationship: regulates GO:0033028 ! myeloid cell apoptosis + +[Term] +id: GO:0033033 +name: negative regulation of myeloid cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptosis." [GOC:add] +synonym: "down regulation of myeloid cell apoptosis" EXACT [] +synonym: "down-regulation of myeloid cell apoptosis" EXACT [] +synonym: "downregulation of myeloid cell apoptosis" EXACT [] +synonym: "inhibition of myeloid cell apoptosis" NARROW [] +is_a: GO:0033032 ! regulation of myeloid cell apoptosis +is_a: GO:0043066 ! negative regulation of apoptosis +relationship: negatively_regulates GO:0033028 ! myeloid cell apoptosis + +[Term] +id: GO:0033034 +name: positive regulation of myeloid cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptosis." [GOC:add] +synonym: "activation of myeloid cell apoptosis" NARROW [] +synonym: "stimulation of myeloid cell apoptosis" NARROW [] +synonym: "up regulation of myeloid cell apoptosis" EXACT [] +synonym: "up-regulation of myeloid cell apoptosis" EXACT [] +synonym: "upregulation of myeloid cell apoptosis" EXACT [] +is_a: GO:0033032 ! regulation of myeloid cell apoptosis +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: positively_regulates GO:0033028 ! myeloid cell apoptosis + +[Term] +id: GO:0033035 +name: dipyrromethane cofactor binding +namespace: biological_process +def: "Interacting selectively with the dipyrromethane cofactor, 3,8-bis(carboxymethyl)-9-methyl-5,10-dihydrodipyrrin-2,7-dipropionic acid." [ChEBI:30410, GOC:mah] +is_a: GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0033036 +name: macromolecule localization +namespace: biological_process +def: "Any process by which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] +subset: gosubset_prok +is_a: GO:0051179 ! localization + +[Term] +id: GO:0033037 +name: polysaccharide localization +namespace: biological_process +def: "Any process by which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] +subset: gosubset_prok +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0033038 +name: bitter taste receptor activity +namespace: molecular_function +def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033039 +name: salty taste receptor activity +namespace: molecular_function +def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033040 +name: sour taste receptor activity +namespace: molecular_function +def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033041 +name: sweet taste receptor activity +namespace: molecular_function +def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033042 +name: umami taste receptor activity +namespace: molecular_function +def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033043 +name: regulation of organelle organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] +synonym: "regulation of organelle organization and biogenesis" EXACT [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006996 ! organelle organization + +[Term] +id: GO:0033044 +name: regulation of chromosome organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] +synonym: "regulation of chromosome organization and biogenesis" EXACT [] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0051276 ! chromosome organization + +[Term] +id: GO:0033045 +name: regulation of sister chromatid segregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: regulates GO:0000819 ! sister chromatid segregation + +[Term] +id: GO:0033046 +name: negative regulation of sister chromatid segregation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0033045 ! regulation of sister chromatid segregation +relationship: negatively_regulates GO:0000819 ! sister chromatid segregation + +[Term] +id: GO:0033047 +name: regulation of mitotic sister chromatid segregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] +is_a: GO:0007088 ! regulation of mitosis +is_a: GO:0033045 ! regulation of sister chromatid segregation +relationship: regulates GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0033048 +name: negative regulation of mitotic sister chromatid segregation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] +is_a: GO:0033046 ! negative regulation of sister chromatid segregation +is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation +relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0033049 +name: clavulanic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [ChEBI:3736, GOC:mah] +synonym: "clavulanic acid metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0033050 +name: clavulanic acid biosythetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [ChEBI:3736, GOC:mah] +synonym: "clavulanic acid anabolism" EXACT [] +synonym: "clavulanic acid biosynthesis" EXACT [] +synonym: "clavulanic acid formation" EXACT [] +synonym: "clavulanic acid synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0033049 ! clavulanic acid metabolic process + +[Term] +id: GO:0033051 +name: aminophosphonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aminophosphonates, amino acid derivatives that contain a phosphonic acid moiety." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, http://www.genome.ad.jp/kegg/pathway/map/map00440.html] +synonym: "aminophosphonate metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0033052 +name: cyanoamino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729] +synonym: "cyanoamino acid metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0033053 +name: D-glutamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glutamine, the dextrorotatory isomer of the amino acid glutamine." [GOC:mah] +subset: gosubset_prok +synonym: "D-glutamine metabolism" EXACT [] +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033054 +name: D-glutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glutamate, the dextrorotatory isomer of the amino acid glutamate." [GOC:mah] +subset: gosubset_prok +synonym: "D-glutamate metabolism" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033055 +name: D-arginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-arginine, the dextrorotatory isomer of the amino acid arginine." [GOC:mah] +subset: gosubset_prok +synonym: "D-arginine metabolism" EXACT [] +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033056 +name: D-ornithine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-ornithine, the dextrorotatory isomer of the amino acid ornithine." [GOC:mah] +subset: gosubset_prok +synonym: "D-ornithine metabolism" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033057 +name: reproductive behavior in a multicellular organism +namespace: biological_process +def: "The specific actions or reactions of an organism that are associated with reproduction in a multicellular organism." [GOC:mtg_MIT_16mar07] +is_a: GO:0019098 ! reproductive behavior +is_a: GO:0048609 ! reproductive process in a multicellular organism + +[Term] +id: GO:0033058 +name: directional locomotion +namespace: biological_process +def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07] +is_a: GO:0040011 ! locomotion + +[Term] +id: GO:0033059 +name: cellular pigmentation +namespace: biological_process +def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0033060 +name: ocellus pigmentation +namespace: biological_process +def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07] +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0033061 +name: DNA recombinase mediator complex +namespace: cellular_component +def: "A protein complex containing two or more Rad51 paralogs and promotes nucleoprotein filament formation during homologous recombination." [GOC:elh, GOC:mah, GOC:vw] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0033062 +name: Rhp55-Rhp57 complex +namespace: cellular_component +def: "A conserved heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw] +synonym: "Rad55-Rad57 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex + +[Term] +id: GO:0033063 +name: Rad51B-Rad51C-Rad51D-XRCC2 complex +namespace: cellular_component +def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] +synonym: "BCDX2 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex + +[Term] +id: GO:0033064 +name: XRCC2-RAD51D complex +namespace: cellular_component +def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548] +synonym: "DX2 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex + +[Term] +id: GO:0033065 +name: Rad51C-XRCC3 complex +namespace: cellular_component +def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] +synonym: "CX3 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex + +[Term] +id: GO:0033066 +name: Rad51B-Rad51C complex +namespace: cellular_component +def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] +synonym: "BC complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex + +[Term] +id: GO:0033067 +name: macrolide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar moieties. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:17298179] +subset: gosubset_prok +synonym: "macrolide metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0030638 ! polyketide metabolic process + +[Term] +id: GO:0033068 +name: macrolide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar moieties. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:17298179] +subset: gosubset_prok +synonym: "macrolide anabolism" EXACT [] +synonym: "macrolide biosynthesis" EXACT [] +synonym: "macrolide formation" EXACT [] +synonym: "macrolide synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0033067 ! macrolide metabolic process + +[Term] +id: GO:0033069 +name: ansamycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] +subset: gosubset_prok +synonym: "ansamycin metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0030638 ! polyketide metabolic process + +[Term] +id: GO:0033070 +name: ansamycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] +subset: gosubset_prok +synonym: "ansamycin anabolism" EXACT [] +synonym: "ansamycin biosynthesis" EXACT [] +synonym: "ansamycin formation" EXACT [] +synonym: "ansamycin synthesis" EXACT [] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0033069 ! ansamycin metabolic process + +[Term] +id: GO:0033071 +name: vancomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [ChEBI:28001, GOC:mah] +subset: gosubset_prok +synonym: "vancomycin metabolism" EXACT [] +is_a: GO:0030650 ! peptide antibiotic metabolic process + +[Term] +id: GO:0033072 +name: vancomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [ChEBI:28001, GOC:mah] +subset: gosubset_prok +synonym: "vancomycin anabolism" EXACT [] +synonym: "vancomycin biosynthesis" EXACT [] +synonym: "vancomycin formation" EXACT [] +synonym: "vancomycin synthesis" EXACT [] +is_a: GO:0019184 ! nonribosomal peptide biosynthetic process +is_a: GO:0033071 ! vancomycin metabolic process + +[Term] +id: GO:0033073 +name: pinene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] +synonym: "pinene metabolism" EXACT [] +is_a: GO:0016098 ! monoterpenoid metabolic process + +[Term] +id: GO:0033074 +name: pinene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] +synonym: "pinene breakdown" EXACT [] +synonym: "pinene catabolism" EXACT [] +synonym: "pinene degradation" EXACT [] +is_a: GO:0016100 ! monoterpenoid catabolic process +is_a: GO:0033073 ! pinene metabolic process + +[Term] +id: GO:0033075 +name: isoquinoline alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] +subset: gosubset_prok +synonym: "ipecac alkaloid biosynthesis" RELATED [] +synonym: "isoquinoline alkaloid anabolism" EXACT [] +synonym: "isoquinoline alkaloid biosynthesis" EXACT [] +synonym: "isoquinoline alkaloid formation" EXACT [] +synonym: "isoquinoline alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process + +[Term] +id: GO:0033076 +name: isoquinoline alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] +subset: gosubset_prok +synonym: "ipecac alkaloid metabolism" RELATED [] +synonym: "isoquinoline alkaloid metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0033077 +name: T cell differentiation in the thymus +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "thymic T cell differentiation" EXACT [] +synonym: "thymocyte cell differentiation" EXACT [] +synonym: "thymocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0033078 +name: extrathymic T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0033079 +name: immature T cell proliferation +namespace: biological_process +def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0033080 +name: immature T cell proliferation in the thymus +namespace: biological_process +def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "thymic T cell proliferation" EXACT [] +synonym: "thymocyte cell proliferation" EXACT [] +synonym: "thymocyte proliferation" EXACT [] +is_a: GO:0033079 ! immature T cell proliferation +relationship: part_of GO:0033077 ! T cell differentiation in the thymus + +[Term] +id: GO:0033081 +name: regulation of T cell differentiation in the thymus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] +synonym: "regulation of thymic T cell differentiation" EXACT [] +synonym: "regulation of thymocyte cell differentiation" EXACT [] +synonym: "regulation of thymocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0033077 ! T cell differentiation in the thymus + +[Term] +id: GO:0033082 +name: regulation of extrathymic T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0033083 +name: regulation of immature T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0042129 ! regulation of T cell proliferation +relationship: regulates GO:0033079 ! immature T cell proliferation + +[Term] +id: GO:0033084 +name: regulation of immature T cell proliferation in the thymus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] +synonym: "regulation of thymic T cell proliferation" EXACT [] +synonym: "regulation of thymocyte cell proliferation" EXACT [] +synonym: "regulation of thymocyte proliferation" EXACT [] +is_a: GO:0033081 ! regulation of T cell differentiation in the thymus +is_a: GO:0033083 ! regulation of immature T cell proliferation +relationship: regulates GO:0033080 ! immature T cell proliferation in the thymus + +[Term] +id: GO:0033085 +name: negative regulation of T cell differentiation in the thymus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] +synonym: "negative regulation of thymic T cell differentiation" EXACT [] +synonym: "negative regulation of thymocyte cell differentiation" EXACT [] +synonym: "negative regulation of thymocyte differentiation" EXACT [] +is_a: GO:0033081 ! regulation of T cell differentiation in the thymus +is_a: GO:0045581 ! negative regulation of T cell differentiation +relationship: negatively_regulates GO:0033077 ! T cell differentiation in the thymus + +[Term] +id: GO:0033086 +name: negative regulation of extrathymic T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] +is_a: GO:0033082 ! regulation of extrathymic T cell differentiation +is_a: GO:0045581 ! negative regulation of T cell differentiation +relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0033087 +name: negative regulation of immature T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0033083 ! regulation of immature T cell proliferation +is_a: GO:0042130 ! negative regulation of T cell proliferation +relationship: negatively_regulates GO:0033079 ! immature T cell proliferation + +[Term] +id: GO:0033088 +name: negative regulation of immature T cell proliferation in the thymus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] +synonym: "negative regulation of thymic T cell proliferation" EXACT [] +synonym: "negative regulation of thymocyte cell proliferation" EXACT [] +synonym: "negative regulation of thymocyte proliferation" EXACT [] +is_a: GO:0033084 ! regulation of immature T cell proliferation in the thymus +is_a: GO:0033087 ! negative regulation of immature T cell proliferation +relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in the thymus + +[Term] +id: GO:0033089 +name: positive regulation of T cell differentiation in the thymus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] +synonym: "positive regulation of thymic T cell differentiation" EXACT [] +synonym: "positive regulation of thymocyte cell differentiation" EXACT [] +synonym: "positive regulation of thymocyte differentiation" EXACT [] +is_a: GO:0033081 ! regulation of T cell differentiation in the thymus +is_a: GO:0045582 ! positive regulation of T cell differentiation +relationship: positively_regulates GO:0033077 ! T cell differentiation in the thymus + +[Term] +id: GO:0033090 +name: positive regulation of extrathymic T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] +is_a: GO:0033082 ! regulation of extrathymic T cell differentiation +is_a: GO:0045582 ! positive regulation of T cell differentiation +relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0033091 +name: positive regulation of immature T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0033083 ! regulation of immature T cell proliferation +is_a: GO:0042102 ! positive regulation of T cell proliferation +relationship: positively_regulates GO:0033079 ! immature T cell proliferation + +[Term] +id: GO:0033092 +name: positive regulation of immature T cell proliferation in the thymus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] +synonym: "positive regulation of thymic T cell proliferation" EXACT [] +synonym: "positive regulation of thymocyte cell proliferation" EXACT [] +synonym: "positive regulation of thymocyte proliferation" EXACT [] +is_a: GO:0033084 ! regulation of immature T cell proliferation in the thymus +is_a: GO:0033091 ! positive regulation of immature T cell proliferation +relationship: positively_regulates GO:0033080 ! immature T cell proliferation in the thymus + +[Term] +id: GO:0033093 +name: Weibel-Palade body +namespace: cellular_component +def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] +is_a: GO:0030136 ! clathrin-coated vesicle +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0033094 +name: putrescine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H(2)O." [EC:2.6.1.82, GOC:mlg] +synonym: "butane-1,4-diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] +synonym: "PAT activity" EXACT [] +synonym: "putrescine transaminase activity" EXACT [] +synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82] +synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] +synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] +synonym: "YgjG" RELATED [EC:2.6.1.82] +xref: EC:2.6.1.82 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033095 +name: aleurone grain +namespace: cellular_component +def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/] +synonym: "aleurone body" EXACT [] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0033096 +name: amyloplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009501 ! amyloplast + +[Term] +id: GO:0033097 +name: amyloplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0033096 ! amyloplast envelope + +[Term] +id: GO:0033098 +name: amyloplast inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0033097 ! amyloplast membrane + +[Term] +id: GO:0033099 +name: attachment organelle +namespace: cellular_component +def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0033100 +name: NuA3 histone acetyltransferase complex +namespace: cellular_component +def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0033101 +name: cellular bud membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah] +synonym: "cellular bud plasma membrane" EXACT [] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005933 ! cellular bud + +[Term] +id: GO:0033102 +name: acidocalcisome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0020022 ! acidocalcisome + +[Term] +id: GO:0033103 +name: protein secretion by the type VI secretion system +namespace: biological_process +def: "The process by which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. +synonym: "protein secretion by the T6SS" EXACT [] +synonym: "protein secretion by the type VI protein secretion system" EXACT [] +synonym: "type VI protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0033104 +name: type VI protein secretion system complex +namespace: cellular_component +def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] +subset: gosubset_prok +synonym: "T6SS complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0033105 +name: chlorosome envelope +namespace: cellular_component +def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128] +comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. +synonym: "chlorosome membrane" EXACT [] +is_a: GO:0034646 ! organelle-enclosing lipid monolayer +relationship: part_of GO:0046858 ! chlorosome + +[Term] +id: GO:0033106 +name: cis-Golgi network membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah] +synonym: "cis Golgi network membrane" EXACT [] +synonym: "Golgi cis face membrane" RELATED [] +is_a: GO:0000139 ! Golgi membrane +relationship: part_of GO:0005801 ! cis-Golgi network + +[Term] +id: GO:0033107 +name: CVT vesicle +namespace: cellular_component +def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0033108 +name: mitochondrial respiratory chain complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0033109 +name: cortical actin cytoskeleton stabilization +namespace: biological_process +def: "The process by which the assembly and arrangement of cytoskeletal structures in the actin cortex with respect to the plasma membrane is maintained." [GOC:mah, GOC:pf] +synonym: "actin cortex stabilization" EXACT [] +synonym: "cortical resistance" RELATED [] +is_a: GO:0030866 ! cortical actin cytoskeleton organization + +[Term] +id: GO:0033110 +name: CVT vesicle membrane +namespace: cellular_component +def: "The double lipid bilayer surrounding a CVT vesicle." [GOC:ecd] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0033107 ! CVT vesicle + +[Term] +id: GO:0033111 +name: attachment organelle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an attachment organelle." [GOC:ecd] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0033099 ! attachment organelle + +[Term] +id: GO:0033112 +name: cyanelle envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0033113 +name: cyanelle membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0033112 ! cyanelle envelope + +[Term] +id: GO:0033114 +name: cyanelle thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah] +is_a: GO:0031978 ! plastid thylakoid lumen +relationship: part_of GO:0009843 ! cyanelle thylakoid + +[Term] +id: GO:0033115 +name: cyanelle thylakoid membrane +namespace: cellular_component +def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah] +is_a: GO:0055035 ! plastid thylakoid membrane +relationship: part_of GO:0009843 ! cyanelle thylakoid + +[Term] +id: GO:0033116 +name: ER-Golgi intermediate compartment membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments of the ER-Golgi intermediate compartment system." [GOC:mah, PMID:16723730] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0005793 ! ER-Golgi intermediate compartment + +[Term] +id: GO:0033117 +name: esterosome +namespace: cellular_component +def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0033118 +name: esterosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0033117 ! esterosome + +[Term] +id: GO:0033119 +name: negative regulation of RNA splicing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] +is_a: GO:0043484 ! regulation of RNA splicing +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0008380 ! RNA splicing + +[Term] +id: GO:0033120 +name: positive regulation of RNA splicing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] +is_a: GO:0043484 ! regulation of RNA splicing +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0008380 ! RNA splicing + +[Term] +id: GO:0033121 +name: regulation of purine nucleotide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] +synonym: "regulation of purine nucleotide breakdown" EXACT [] +synonym: "regulation of purine nucleotide catabolism" EXACT [] +synonym: "regulation of purine nucleotide degradation" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +relationship: regulates GO:0006195 ! purine nucleotide catabolic process + +[Term] +id: GO:0033122 +name: negative regulation of purine nucleotide catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] +synonym: "negative regulation of purine nucleotide breakdown" EXACT [] +synonym: "negative regulation of purine nucleotide catabolism" EXACT [] +synonym: "negative regulation of purine nucleotide degradation" EXACT [] +is_a: GO:0030812 ! negative regulation of nucleotide catabolic process +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process + +[Term] +id: GO:0033123 +name: positive regulation of purine nucleotide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] +synonym: "positive regulation of purine nucleotide breakdown" EXACT [] +synonym: "positive regulation of purine nucleotide catabolism" EXACT [] +synonym: "positive regulation of purine nucleotide degradation" EXACT [] +is_a: GO:0030813 ! positive regulation of nucleotide catabolic process +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process + +[Term] +id: GO:0033124 +name: regulation of GTP catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] +synonym: "regulation of GTP breakdown" EXACT [] +synonym: "regulation of GTP catabolism" EXACT [] +synonym: "regulation of GTP degradation" EXACT [] +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +relationship: regulates GO:0006184 ! GTP catabolic process + +[Term] +id: GO:0033125 +name: negative regulation of GTP catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] +synonym: "negative regulation of GTP breakdown" EXACT [] +synonym: "negative regulation of GTP catabolism" EXACT [] +synonym: "negative regulation of GTP degradation" EXACT [] +is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process +is_a: GO:0033124 ! regulation of GTP catabolic process +relationship: negatively_regulates GO:0006184 ! GTP catabolic process + +[Term] +id: GO:0033126 +name: positive regulation of GTP catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] +synonym: "positive regulation of GTP breakdown" EXACT [] +synonym: "positive regulation of GTP catabolism" EXACT [] +synonym: "positive regulation of GTP degradation" EXACT [] +is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process +is_a: GO:0033124 ! regulation of GTP catabolic process +relationship: positively_regulates GO:0006184 ! GTP catabolic process + +[Term] +id: GO:0033127 +name: regulation of histone phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +is_a: GO:0031056 ! regulation of histone modification +relationship: regulates GO:0016572 ! histone phosphorylation + +[Term] +id: GO:0033128 +name: negative regulation of histone phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] +is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0033127 ! regulation of histone phosphorylation +relationship: negatively_regulates GO:0016572 ! histone phosphorylation + +[Term] +id: GO:0033129 +name: positive regulation of histone phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] +is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0033127 ! regulation of histone phosphorylation +relationship: positively_regulates GO:0016572 ! histone phosphorylation + +[Term] +id: GO:0033130 +name: acetylcholine receptor binding +namespace: molecular_function +def: "Interacting selectively with an acetylcholine receptor." [GOC:mah] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0033131 +name: regulation of glucokinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] +synonym: "glucokinase regulator" NARROW [] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0033132 +name: negative regulation of glucokinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] +synonym: "down regulation of glucokinase activity" EXACT [] +synonym: "down-regulation of glucokinase activity" EXACT [] +synonym: "downregulation of glucokinase activity" EXACT [] +synonym: "glucokinase inhibitor" NARROW [] +synonym: "inhibition of glucokinase activity" NARROW [] +is_a: GO:0033131 ! regulation of glucokinase activity +is_a: GO:0033673 ! negative regulation of kinase activity + +[Term] +id: GO:0033133 +name: positive regulation of glucokinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] +synonym: "glucokinase activator" NARROW [] +synonym: "stimulation of glucokinase activity" NARROW [] +synonym: "up regulation of glucokinase activity" EXACT [] +synonym: "up-regulation of glucokinase activity" EXACT [] +synonym: "upregulation of glucokinase activity" EXACT [] +is_a: GO:0033131 ! regulation of glucokinase activity +is_a: GO:0033674 ! positive regulation of kinase activity + +[Term] +id: GO:0033134 +name: ubiquitin activating enzyme binding +namespace: molecular_function +def: "Interacting selectively with a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0033135 +name: regulation of peptidyl-serine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] +subset: gosubset_prok +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0033136 +name: serine phosphorylation of STAT3 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a serine residue of the STAT3 protein." [GOC:jl, GOC:mah] +is_a: GO:0042501 ! serine phosphorylation of STAT protein + +[Term] +id: GO:0033137 +name: negative regulation of peptidyl-serine phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] +is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation +is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation +relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0033138 +name: positive regulation of peptidyl-serine phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] +is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation +is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation +relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0033139 +name: regulation of peptidyl-serine phosphorylation of STAT protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation +relationship: part_of GO:0042501 ! serine phosphorylation of STAT protein + +[Term] +id: GO:0033140 +name: negative regulation of peptidyl-serine phosphorylation of STAT protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation +is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein + +[Term] +id: GO:0033141 +name: positive regulation of peptidyl-serine phosphorylation of STAT protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation +is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein + +[Term] +id: GO:0033142 +name: progesterone receptor binding +namespace: molecular_function +def: "Interacting selectively with a progesterone receptor." [GOC:mah] +is_a: GO:0035258 ! steroid hormone receptor binding + +[Term] +id: GO:0033143 +name: regulation of steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah] +synonym: "regulation of steroid hormone receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0033144 +name: negative regulation of steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah] +synonym: "negative regulation of steroid hormone receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway +relationship: negatively_regulates GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0033145 +name: positive regulation of steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah] +synonym: "positive regulation of steroid hormone receptor signalling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway +relationship: positively_regulates GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0033146 +name: regulation of estrogen receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah] +synonym: "regulation of estrogen receptor signalling pathway" EXACT [] +is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway +relationship: regulates GO:0030520 ! estrogen receptor signaling pathway + +[Term] +id: GO:0033147 +name: negative regulation of estrogen receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah] +synonym: "negative regulation of estrogen receptor signalling pathway" EXACT [] +is_a: GO:0033144 ! negative regulation of steroid hormone receptor signaling pathway +is_a: GO:0033146 ! regulation of estrogen receptor signaling pathway +relationship: negatively_regulates GO:0030520 ! estrogen receptor signaling pathway + +[Term] +id: GO:0033148 +name: positive regulation of estrogen receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah] +synonym: "positive regulation of estrogen receptor signalling pathway" EXACT [] +is_a: GO:0033145 ! positive regulation of steroid hormone receptor signaling pathway +is_a: GO:0033146 ! regulation of estrogen receptor signaling pathway +relationship: positively_regulates GO:0030520 ! estrogen receptor signaling pathway + +[Term] +id: GO:0033149 +name: FFAT motif binding +namespace: molecular_function +def: "Interacting selectively with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0033150 +name: cytoskeletal calyx +namespace: cellular_component +def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0033011 ! perinuclear theca + +[Term] +id: GO:0033151 +name: V(D)J recombination +namespace: biological_process +def: "The process by which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149 "Fundamental Immunology"] +synonym: "V(D)J joining" EXACT [] +synonym: "V-D-J joining" EXACT [] +synonym: "V-D-J recombination" EXACT [] +synonym: "V-J joining" EXACT [] +synonym: "V-J recombination" EXACT [] +is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus + +[Term] +id: GO:0033152 +name: immunoglobulin V(D)J recombination +namespace: biological_process +def: "The process by which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin light chains the same process is used to join V and J gene segments directly." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "immunoglobulin V(D)J joining" EXACT [] +synonym: "immunoglobulin V-D-J joining" EXACT [] +synonym: "immunoglobulin V-D-J recombination" EXACT [] +synonym: "immunoglobulin V-J joining" EXACT [] +synonym: "immunoglobulin V-J recombination" EXACT [] +is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments +is_a: GO:0033151 ! V(D)J recombination + +[Term] +id: GO:0033153 +name: T cell receptor V(D)J recombination +namespace: biological_process +def: "The process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221] +synonym: "T cell receptor V(D)J joining" EXACT [] +synonym: "T cell receptor V-D-J joining" EXACT [] +synonym: "T cell receptor V-D-J recombination" EXACT [] +synonym: "T cell receptor V-J joining" EXACT [] +synonym: "T cell receptor V-J recombination" EXACT [] +synonym: "T-cell receptor V(D)J recombination" EXACT [] +synonym: "TCR V(D)J recombination" EXACT [] +is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments +is_a: GO:0033151 ! V(D)J recombination + +[Term] +id: GO:0033154 +name: oligogalacturonide transporting ATPase +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg] +is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity +is_a: GO:0015478 ! oligosaccharide transporting porin activity + +[Term] +id: GO:0033155 +name: oligogalacturonide transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of oligogalacturonide from one side of the membrane to the other." [GOC:mlg] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity + +[Term] +id: GO:0033156 +name: oligogalacturonide transport +namespace: biological_process +def: "The directed movement of oligogalacturonides into, out of, within or between cells." [GOC:mlg] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:0033157 +name: regulation of intracellular protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0051223 ! regulation of protein transport +relationship: regulates GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0033158 +name: regulation of protein import into nucleus, translocation +namespace: biological_process +def: "Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +synonym: "regulation of protein import into cell nucleus, translocation" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +relationship: regulates GO:0000060 ! protein import into nucleus, translocation + +[Term] +id: GO:0033159 +name: negative regulation of protein import into nucleus, translocation +namespace: biological_process +def: "Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT [] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0033158 ! regulation of protein import into nucleus, translocation +is_a: GO:0051224 ! negative regulation of protein transport +relationship: negatively_regulates GO:0000060 ! protein import into nucleus, translocation + +[Term] +id: GO:0033160 +name: positive regulation of protein import into nucleus, translocation +namespace: biological_process +def: "Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT [] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0033158 ! regulation of protein import into nucleus, translocation +is_a: GO:0051222 ! positive regulation of protein transport +relationship: positively_regulates GO:0000060 ! protein import into nucleus, translocation + +[Term] +id: GO:0033161 +name: mitogen-activated protein kinase kinase kinase kinase binding +namespace: molecular_function +def: "Interacting selectively with a mitogen-activated protein kinase kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah] +synonym: "MAPKKKK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0033162 +name: melanosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a melanosome." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0042470 ! melanosome +relationship: part_of GO:0045009 ! chitosome + +[Term] +id: GO:0033163 +name: microneme membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a microneme." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0020009 ! microneme + +[Term] +id: GO:0033164 +name: glycolipid 6-alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,6-D-mannosyl-D-mannose linkage." [EC:2.4.1.232, GOC:mcc, PMID:16878994] +synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] +synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232] +synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.232] +xref: EC:2.4.1.231 +is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity +is_a: GO:0004376 ! glycolipid mannosyltransferase activity + +[Term] +id: GO:0033165 +name: interphotoreceptor matrix +namespace: cellular_component +def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288] +is_a: GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0033166 +name: hyaline layer +namespace: cellular_component +def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317] +is_a: GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0033167 +name: ARC complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250] +synonym: "argonaute siRNA chaperone complex" EXACT [] +is_a: GO:0031332 ! RNAi effector complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0033168 +name: RNA interference, conversion of ds siRNA to ss siRNA +namespace: biological_process +def: "The process by which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250] +is_a: GO:0006396 ! RNA processing +relationship: part_of GO:0030422 ! RNA interference, production of siRNA + +[Term] +id: GO:0033169 +name: histone H3-K9 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0033170 +name: DNA-protein loading ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of a protein or protein complex onto a DNA molecule." [GOC:mah, GOC:vw] +is_a: GO:0008094 ! DNA-dependent ATPase activity + +[Term] +id: GO:0033171 +name: nucleoprotein filament-forming ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw] +comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading. +is_obsolete: true + +[Term] +id: GO:0033172 +name: gas vesicle shell +namespace: cellular_component +def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd] +synonym: "gas vesicle membrane" RELATED [] +synonym: "gas vesicle wall" EXACT [] +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0031411 ! gas vesicle + +[Term] +id: GO:0033173 +name: calcineurin-NFAT signaling pathway +namespace: biological_process +def: "A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin." [GOC:lm, GOC:mah, PMID:15928679] +synonym: "calcineurin-NFAT signalling pathway" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0048016 ! inositol phosphate-mediated signaling + +[Term] +id: GO:0033174 +name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) +namespace: cellular_component +def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839] +synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT [] +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) +relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex + +[Term] +id: GO:0033175 +name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) +namespace: cellular_component +def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah] +synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT [] +synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT [] +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) +relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex + +[Term] +id: GO:0033176 +name: proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553] +synonym: "hydrogen-translocating V-type ATPase complex" EXACT [] +is_a: GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0033177 +name: proton-transporting two-sector ATPase complex, proton-transporting domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0033178 +name: proton-transporting two-sector ATPase complex, catalytic domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0033179 +name: proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] +is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain +relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex + +[Term] +id: GO:0033180 +name: proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] +is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain +relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex + +[Term] +id: GO:0033181 +name: plasma membrane proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] +synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT [] +is_a: GO:0033176 ! proton-transporting V-type ATPase complex + +[Term] +id: GO:0033182 +name: regulation of histone ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein." [GOC:mah] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0031396 ! regulation of protein ubiquitination +relationship: regulates GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033183 +name: negative regulation of histone ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein." [GOC:mah] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0031397 ! negative regulation of protein ubiquitination +is_a: GO:0033182 ! regulation of histone ubiquitination +relationship: negatively_regulates GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033184 +name: positive regulation of histone ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein." [GOC:mah] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0031398 ! positive regulation of protein ubiquitination +is_a: GO:0033182 ! regulation of histone ubiquitination +relationship: positively_regulates GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033185 +name: dolichol-phosphate-mannose synthase complex +namespace: cellular_component +def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346] +synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT [] +synonym: "DPM synthase complex" EXACT [] +is_a: GO:0031501 ! mannosyltransferase complex + +[Term] +id: GO:0033186 +name: CAF-1 complex +namespace: cellular_component +def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] +synonym: "chromatin assembly factor 1 complex" EXACT [] +is_a: GO:0005678 ! chromatin assembly complex + +[Term] +id: GO:0033187 +name: inositol hexakisphosphate 4-kinase or 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate or ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959] +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0033188 +name: sphingomyelin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol." [EC:2.7.8.27] +synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" EXACT [EC:2.7.8.27] +synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" EXACT [EC:2.7.8.27] +synonym: "SM synthase activity" EXACT [EC:2.7.8.27] +synonym: "SMS1" RELATED [EC:2.7.8.27] +synonym: "SMS2" RELATED [EC:2.7.8.27] +xref: EC:2.7.8.27 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0033189 +name: response to vitamin A +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl] +synonym: "response to retinol" NARROW [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033190 +name: solanapyrone synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0033191 +name: macrophomate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [ChEBI:38228, GOC:cb, PMID:10984474] +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0033192 +name: calmodulin-dependent protein phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] +synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED [] +synonym: "calcineurin activity" NARROW [] +synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT [] +synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT [] +is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity + +[Term] +id: GO:0033193 +name: Lsd1/2 complex +namespace: cellular_component +def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621] +synonym: "SAPHIRE complex" EXACT [PMID:17371846] +synonym: "Swm complex" EXACT [PMID:17440621] +synonym: "Swm1/2 complex" RELATED [PMID:17440621] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0033194 +name: response to hydroperoxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [ChEBI:35923, GOC:mah] +subset: gosubset_prok +is_a: GO:0006979 ! response to oxidative stress + +[Term] +id: GO:0033195 +name: response to alkyl hydroperoxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [ChEBI:35923, GOC:mah] +is_a: GO:0033194 ! response to hydroperoxide + +[Term] +id: GO:0033196 +name: tryparedoxin peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O." [GOC:mah] +synonym: "TXNPx activity" EXACT [] +is_a: GO:0051920 ! peroxiredoxin activity + +[Term] +id: GO:0033197 +name: response to vitamin E +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl] +synonym: "response to DL-alpha-tocopherol acetate" NARROW [] +synonym: "response to DL-alpha-tocopheryl acetate" NARROW [] +synonym: "response to O-Acetyl-alpha-tocopherol" NARROW [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033198 +name: response to ATP +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl] +synonym: "response to adenosine 5'-triphosphate" EXACT [] +synonym: "response to adenosine triphosphate" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0033199 +name: inositol heptakisphosphate 4-kinase or 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] +is_a: GO:0000829 ! inositol heptakisphosphate kinase activity + +[Term] +id: GO:0033200 +name: inositol heptakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] +synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT [] +synonym: "IP7 5-kinase activity" EXACT [] +is_a: GO:0000829 ! inositol heptakisphosphate kinase activity + +[Term] +id: GO:0033201 +name: alpha-1,4-glucan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966] +synonym: "1,4-alpha-glucan synthase activity" EXACT [] +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0033202 +name: DNA helicase complex +namespace: cellular_component +def: "A protein complex that possesses DNA helicase activity." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0033203 +name: DNA helicase A complex +namespace: cellular_component +def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218] +is_a: GO:0033202 ! DNA helicase complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0033204 +name: ribonuclease P RNA binding +namespace: molecular_function +def: "Interacting selectively with the RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963] +synonym: "RNase P RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0033205 +name: cytokinesis during cell cycle +namespace: biological_process +def: "Cytokinesis that occurs in the context of cell cycle progression and result in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] +is_a: GO:0000910 ! cytokinesis +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0033206 +name: cytokinesis after meiosis +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mah] +is_a: GO:0033205 ! cytokinesis during cell cycle + +[Term] +id: GO:0033207 +name: beta-1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah] +synonym: "beta-1,4-GalNAc transferase activity" EXACT [] +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0033208 +name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623] +synonym: "Sda beta 1,4GalNAc transferase" RELATED [] +synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] +is_a: GO:0033207 ! beta-1,4-N-acetylgalactosaminyltransferase activity + +[Term] +id: GO:0033209 +name: tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:mah] +synonym: "adipocytokine signaling pathway" RELATED [] +synonym: "TNF-alpha-mediated signaling pathway" EXACT [] +synonym: "tumor necrosis factor alpha-mediated signaling pathway" EXACT [] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0033210 +name: leptin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor." [GOC:mah] +synonym: "adipocytokine signaling pathway" RELATED [] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0033211 +name: adiponectin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor." [GOC:mah] +synonym: "adipocytokine signaling pathway" RELATED [] +synonym: "adiponectin-mediated signalling pathway" EXACT [] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0033212 +name: iron assimilation +namespace: biological_process +def: "A process by which iron is solubilized and transported into a cell." [GOC:mah] +is_a: GO:0006879 ! cellular iron ion homeostasis + +[Term] +id: GO:0033213 +name: iron assimilation by capture and transport +namespace: biological_process +def: "A process by which iron (Fe3+) is solubilized by binding to a receptor or transport protein and transported into a cell." [GOC:mah] +is_a: GO:0033212 ! iron assimilation + +[Term] +id: GO:0033214 +name: iron assimilation by chelation and transport +namespace: biological_process +def: "A process by which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626] +is_a: GO:0033212 ! iron assimilation + +[Term] +id: GO:0033215 +name: iron assimilation by reduction and transport +namespace: biological_process +def: "A process by which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:mah, PMID:16963626] +is_a: GO:0033212 ! iron assimilation + +[Term] +id: GO:0033216 +name: ferric iron import +namespace: biological_process +def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle." [GOC:mah] +synonym: "ferric ion import" EXACT [] +synonym: "ferric iron uptake" EXACT [] +is_a: GO:0015682 ! ferric iron transport + +[Term] +id: GO:0033217 +name: regulation of transcription from RNA polymerase II promoter in response to iron ion starvation +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of iron ions." [GOC:mah] +synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [] +is_a: GO:0010106 ! cellular response to iron ion starvation +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0033218 +name: amide binding +namespace: molecular_function +def: "Interacting selectively with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988, GOC:mah] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0033219 +name: urea binding +namespace: molecular_function +def: "Interacting selectively with urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [ChEBI:16199, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0033218 ! amide binding + +[Term] +id: GO:0033220 +name: amide-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah] +subset: gosubset_prok +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances +is_a: GO:0042887 ! amide transporter activity + +[Term] +id: GO:0033221 +name: urea-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg] +subset: gosubset_prok +synonym: "carbamide-transporting ATPase activity" EXACT [] +is_a: GO:0015204 ! urea transmembrane transporter activity +is_a: GO:0033220 ! amide-transporting ATPase activity + +[Term] +id: GO:0033222 +name: xylose binding +namespace: molecular_function +def: "Interacting selectively with the D- or L-enantiomer of xylose." [ChEBI:18222, GOC:mah] +subset: gosubset_prok +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0033223 +name: 2-aminoethylphosphonate transport +namespace: biological_process +def: "The directed movement of 2-aminoethylphosphonate, into, out of, within or between cells." [GOC:mlg] +synonym: "2-phosphonoethylamine transport" EXACT [] +synonym: "ciliatine transport" EXACT [] +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0033224 +name: 2-aminoethylphosphonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of 2-aminoethylphosphonate into, out of, within or between cells." [GOC:mlg] +synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT [] +synonym: "ciliatine transporter activity" EXACT [] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0033225 +name: 2-aminoethylphosphonate transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg] +synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT [] +synonym: "ciliatine transportingATPase activity" EXACT [] +is_a: GO:0031263 ! amine-transporting ATPase activity +is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity + +[Term] +id: GO:0033226 +name: 2-aminoethylphosphonate binding +namespace: molecular_function +def: "Interacting selectively with 2-aminoethylphosphonate." [GOC:mlg] +synonym: "2-phosphonoethylamine binding" EXACT [] +synonym: "ciliatine binding" EXACT [] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0033227 +name: dsRNA transport +namespace: biological_process +def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of, within or between cells." [GOC:mah] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0033228 +name: cysteine export +namespace: biological_process +def: "The directed movement of cysteine out of a cell or organelle." [GOC:mlg] +is_a: GO:0032973 ! amino acid export +is_a: GO:0042883 ! cysteine transport + +[Term] +id: GO:0033229 +name: cysteine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of cysteine from one side of the membrane to the other." [GOC:mah] +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity + +[Term] +id: GO:0033230 +name: cysteine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg] +is_a: GO:0015424 ! amino acid-transporting ATPase activity +is_a: GO:0033229 ! cysteine transmembrane transporter activity + +[Term] +id: GO:0033231 +name: carbohydrate export +namespace: biological_process +def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0033232 +name: D-methionine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg] +is_a: GO:0015424 ! amino acid-transporting ATPase activity +is_a: GO:0048474 ! D-methionine transmembrane transporter activity + +[Term] +id: GO:0033233 +name: regulation of protein sumoylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of SUMO moieties to a protein." [GOC:mah] +synonym: "regulation of sumoylation" EXACT [] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0016925 ! protein sumoylation + +[Term] +id: GO:0033234 +name: negative regulation of protein sumoylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of SUMO moieties to a protein." [GOC:mah] +synonym: "negative regulation of sumoylation" EXACT [] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0033233 ! regulation of protein sumoylation +relationship: negatively_regulates GO:0016925 ! protein sumoylation + +[Term] +id: GO:0033235 +name: positive regulation of protein sumoylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO moieties to a protein." [GOC:mah] +synonym: "positive regulation of sumoylation" EXACT [] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0033233 ! regulation of protein sumoylation +relationship: positively_regulates GO:0016925 ! protein sumoylation + +[Term] +id: GO:0033236 +name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036] +is_obsolete: true + +[Term] +id: GO:0033237 +name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] +synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146] +synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] +synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146] +xref: EC:1.1.1.146 +xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN +is_obsolete: true + +[Term] +id: GO:0033238 +name: regulation of amine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] +subset: gosubset_prok +synonym: "regulation of amine metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0033239 +name: negative regulation of amine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] +synonym: "negative regulation of amine metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0033238 ! regulation of amine metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0033240 +name: positive regulation of amine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] +synonym: "positive regulation of amine metabolism" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0033238 ! regulation of amine metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0033241 +name: regulation of amine catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "regulation of amine breakdown" EXACT [] +synonym: "regulation of amine catabolism" EXACT [] +synonym: "regulation of amine degradation" EXACT [] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0033238 ! regulation of amine metabolic process +relationship: regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033242 +name: negative regulation of amine catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "negative regulation of amine breakdown" EXACT [] +synonym: "negative regulation of amine catabolism" EXACT [] +synonym: "negative regulation of amine degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0033239 ! negative regulation of amine metabolic process +is_a: GO:0033241 ! regulation of amine catabolic process +relationship: negatively_regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033243 +name: positive regulation of amine catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "positive regulation of amine breakdown" EXACT [] +synonym: "positive regulation of amine catabolism" EXACT [] +synonym: "positive regulation of amine degradation" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0033240 ! positive regulation of amine metabolic process +is_a: GO:0033241 ! regulation of amine catabolic process +relationship: positively_regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033244 +name: regulation of penicillin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "regulation of penicillin metabolism" EXACT [] +is_a: GO:0033238 ! regulation of amine metabolic process +relationship: regulates GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0033245 +name: negative regulation of penicillin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "negative regulation of penicillin metabolism" EXACT [] +is_a: GO:0033239 ! negative regulation of amine metabolic process +is_a: GO:0033244 ! regulation of penicillin metabolic process +relationship: negatively_regulates GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0033246 +name: positive regulation of penicillin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "positive regulation of penicillin metabolism" EXACT [] +is_a: GO:0033240 ! positive regulation of amine metabolic process +is_a: GO:0033244 ! regulation of penicillin metabolic process +relationship: positively_regulates GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0033247 +name: regulation of penicillin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "regulation of penicillin breakdown" EXACT [] +synonym: "regulation of penicillin catabolism" EXACT [] +synonym: "regulation of penicillin degradation" EXACT [] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0033244 ! regulation of penicillin metabolic process +relationship: regulates GO:0042317 ! penicillin catabolic process + +[Term] +id: GO:0033248 +name: negative regulation of penicillin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "negative regulation of penicillin breakdown" EXACT [] +synonym: "negative regulation of penicillin catabolism" EXACT [] +synonym: "negative regulation of penicillin degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0033245 ! negative regulation of penicillin metabolic process +is_a: GO:0033247 ! regulation of penicillin catabolic process +relationship: negatively_regulates GO:0042317 ! penicillin catabolic process + +[Term] +id: GO:0033249 +name: positive regulation of penicillin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "positive regulation of penicillin breakdown" EXACT [] +synonym: "positive regulation of penicillin catabolism" EXACT [] +synonym: "positive regulation of penicillin degradation" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0033246 ! positive regulation of penicillin metabolic process +is_a: GO:0033247 ! regulation of penicillin catabolic process +relationship: positively_regulates GO:0042317 ! penicillin catabolic process + +[Term] +id: GO:0033250 +name: penicillinase activity +namespace: molecular_function +def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg] +is_a: GO:0008800 ! beta-lactamase activity + +[Term] +id: GO:0033251 +name: cephalosporinase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg] +is_a: GO:0008800 ! beta-lactamase activity + +[Term] +id: GO:0033252 +name: regulation of beta-lactamase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0033253 +name: regulation of penicillinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah] +is_a: GO:0033252 ! regulation of beta-lactamase activity + +[Term] +id: GO:0033254 +name: vacuolar transporter chaperone complex +namespace: cellular_component +def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729] +synonym: "VTC complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0033255 +name: SAS acetyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653] +synonym: "SAS-I complex" EXACT [] +is_a: GO:0032777 ! Piccolo NuA4 histone acetyltransferase complex + +[Term] +id: GO:0033256 +name: I-kappaB/NF-kappaB complex +namespace: cellular_component +def: "A protein complex containing an I-kappaB protein and one or more copies of an NF-kappaB protein; mediates regulation of NF-kappaB activity by I-kappaB." [GOC:mah, PMID:9407099] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0033257 +name: Bcl3/NF-kappaB2 complex +namespace: cellular_component +def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] +synonym: "Bcl3-NFKB2 complex" RELATED [] +synonym: "Bcl3-p52 complex" EXACT [] +is_a: GO:0033256 ! I-kappaB/NF-kappaB complex + +[Term] +id: GO:0033258 +name: plastid DNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah] +synonym: "plastid DNA metabolism" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0009657 ! plastid organization + +[Term] +id: GO:0033259 +name: plastid DNA replication +namespace: biological_process +def: "The process whereby new strands of DNA are synthesized in a plastid." [GOC:mah] +synonym: "plastid DNA synthesis" RELATED [] +synonym: "replication of plastid DNA" EXACT [] +is_a: GO:0006261 ! DNA-dependent DNA replication +is_a: GO:0033258 ! plastid DNA metabolic process + +[Term] +id: GO:0033260 +name: DNA replication during S phase +namespace: biological_process +def: "The process whereby new strands of genomic DNA are synthesized, using parental DNA as a template for DNA-dependent DNA polymerases, during progression through S phase of the cell cycle." [GOC:mah] +is_a: GO:0006261 ! DNA-dependent DNA replication +relationship: part_of GO:0051320 ! S phase + +[Term] +id: GO:0033261 +name: regulation of S phase +namespace: biological_process +def: "A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb] +xref: MetaCyc:PWY-5043 +xref: MetaCyc:SALVADEHYPOX-PWY +xref: MetaCyc:SALVPURINE2-PWY +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0051320 ! S phase + +[Term] +id: GO:0033262 +name: regulation of DNA replication during S phase +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA replication during progression through S phase of the cell cycle." [GOC:mah] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0033261 ! regulation of S phase +relationship: regulates GO:0033260 ! DNA replication during S phase + +[Term] +id: GO:0033263 +name: CORVET complex +namespace: cellular_component +def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] +is_a: GO:0043234 ! protein complex +is_a: GO:0044440 ! endosomal part + +[Term] +id: GO:0033264 +name: bontoxilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "BoNT" RELATED [EC:3.4.24.69] +synonym: "botulinum neurotoxin activity" EXACT [] +xref: EC:3.4.24.69 +xref: MetaCyc:3.4.24.69-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0033265 +name: choline binding +namespace: molecular_function +def: "Interacting selectively with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [ChEBI:15354, GOC:mlg] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0033266 +name: choline-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of choline across a membrane." [GOC:mlg] +is_a: GO:0015220 ! choline transmembrane transporter activity +is_a: GO:0031263 ! amine-transporting ATPase activity + +[Term] +id: GO:0033267 +name: axon part +namespace: cellular_component +def: "A cell projection part that is part of an axon." [GOC:mh] +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:0033268 +name: node of Ranvier +namespace: cellular_component +def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0033269 +name: internode region of axon +namespace: cellular_component +def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0033270 +name: paranode region of axon +namespace: cellular_component +def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0033271 +name: myo-inositol phosphate transport +namespace: biological_process +def: "The directed movement of any phosphorylated myo-inositol into, out of, within or between cells." [GOC:mah] +is_a: GO:0015798 ! myo-inositol transport + +[Term] +id: GO:0033272 +name: myo-inositol hexakisphosphate transport +namespace: biological_process +def: "The directed movement of myo-inositol hexakisphosphate into, out of, within or between cells." [ChEBI:17401, GOC:mah] +synonym: "phytate transport" EXACT [] +is_a: GO:0033271 ! myo-inositol phosphate transport + +[Term] +id: GO:0033273 +name: response to vitamin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl] +is_a: GO:0007584 ! response to nutrient + +[Term] +id: GO:0033274 +name: response to vitamin B2 +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl] +synonym: "response to riboflavin" EXACT [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033275 +name: actin-myosin filament sliding +namespace: biological_process +def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf] +synonym: "actin filament sliding" RELATED [] +is_a: GO:0030048 ! actin filament-based movement + +[Term] +id: GO:0033276 +name: transcription factor TFTC complex +namespace: cellular_component +def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0033277 +name: abortive mitotic cell cycle +namespace: biological_process +def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008] +comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. +synonym: "abortive mitosis" RELATED [] +is_a: GO:0007049 ! cell cycle + +[Term] +id: GO:0033278 +name: cell proliferation in midbrain +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GOC:df] +comment: This term was added by GO_REF:0000021. +synonym: "cell proliferation in mesencephalon" EXACT [] +synonym: "mesencepahalic cell proliferation" RELATED [] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0030901 ! midbrain development + +[Term] +id: GO:0033279 +name: ribosomal subunit +namespace: cellular_component +def: "Either of the two ribonucleoprotein complexes that associate to form a ribosome." [GOC:mah] +subset: gosubset_prok +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005840 ! ribosome + +[Term] +id: GO:0033280 +name: response to vitamin D +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl] +synonym: "response to calciferol" EXACT [] +synonym: "response to cholecalciferol" NARROW [] +synonym: "response to ergocalciferol" NARROW [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033281 +name: TAT protein transport complex +namespace: cellular_component +def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators] +subset: gosubset_prok +synonym: "TAT protein secretion complex" NARROW [] +synonym: "TAT protein translocation system complex" NARROW [] +synonym: "Twin-arginine translocation complex " NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0033282 +name: protein C inhibitor-acrosin complex +namespace: cellular_component +def: "A heterodimeric protein complex of protein C inhibitor and acrosin; complex formation inhibits the protease activity of acrosin." [PMID:11120760, PMID:7521127] +synonym: "PCI-ACR complex" EXACT [] +synonym: "PCI-acrosin complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0002080 ! acrosomal membrane + +[Term] +id: GO:0033283 +name: organic acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg] +is_a: GO:0005342 ! organic acid transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0033284 +name: carboxylic acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg] +is_a: GO:0033283 ! organic acid-transporting ATPase activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0033285 +name: monocarboxylic acid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0033284 ! carboxylic acid-transporting ATPase activity + +[Term] +id: GO:0033286 +name: ectoine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg] +is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity +is_a: GO:0051471 ! ectoine transmembrane transporter activity + +[Term] +id: GO:0033287 +name: hydroxyectoine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of hydroxyectoine from one side of the membrane to the other." [GOC:mlg] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0033288 +name: hydroxyectoine-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg] +is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity +is_a: GO:0033287 ! hydroxyectoine transmembrane transporter activity + +[Term] +id: GO:0033289 +name: intraconoid microtubule +namespace: cellular_component +def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0033290 +name: eukaryotic 48S preinitiation complex +namespace: cellular_component +alt_id: GO:0016283 +def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] +synonym: "eukaryotic 48S initiation complex" RELATED [] +synonym: "eukaryotic 48S pre-initiation complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0033291 +name: eukaryotic 80S initiation complex +namespace: cellular_component +def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0033292 +name: T-tubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah] +synonym: "T-tubule organization and biogenesis" EXACT [] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0007009 ! plasma membrane organization +relationship: part_of GO:0055001 ! muscle cell development + +[Term] +id: GO:0033293 +name: monocarboxylic acid binding +namespace: molecular_function +def: "Interacting selectively with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] +subset: gosubset_prok +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0033294 +name: ectoine binding +namespace: molecular_function +def: "Interacting selectively with ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah] +is_a: GO:0033293 ! monocarboxylic acid binding + +[Term] +id: GO:0033295 +name: hydroxyectoine binding +namespace: molecular_function +def: "Interacting selectively with hydroxyectoine." [GOC:mlg] +is_a: GO:0033293 ! monocarboxylic acid binding + +[Term] +id: GO:0033296 +name: rhamnose binding +namespace: molecular_function +def: "Interacting selectively with the D- or L-enantiomer of rhamnose." [ChEBI:26546, GOC:mah] +subset: gosubset_prok +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0033297 +name: rhamnose-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + rhamnose(out/in) = ADP + phosphate + rhamnose(in/out)." [GOC:mlg] +is_a: GO:0015153 ! rhamnose transmembrane transporter activity +is_a: GO:0015407 ! monosaccharide-transporting ATPase activity + +[Term] +id: GO:0033298 +name: contractile vacuole organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah] +synonym: "contractile vacuole organization and biogenesis" EXACT [] +is_a: GO:0007033 ! vacuole organization + +[Term] +id: GO:0033299 +name: secretion of lysosomal enzymes +namespace: biological_process +def: "The regulated release of lysosomal enzymes by a cell or group of cells." [GOC:mah] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0033300 +name: dehydroascorbic acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of, within or between cells." [ChEBI:17242] +synonym: "dehydroascorbate transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0033301 +name: cell cycle comprising mitosis without cytokinesis +namespace: biological_process +def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah] +comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. +is_a: GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0033302 +name: quercetin O-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [ChEBI:28299, ChEBI:28529, GOC:mah, MetaCyc:PWY-5321] +synonym: "quercetin O-glucoside metabolism" EXACT [] +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0033303 +name: quercetin O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [ChEBI:28299, ChEBI:28529, GOC:mah, MetaCyc:PWY-5321] +synonym: "quercetin O-glucoside anabolism" EXACT [] +synonym: "quercetin O-glucoside biosynthesis" EXACT [] +synonym: "quercetin O-glucoside formation" EXACT [] +synonym: "quercetin O-glucoside synthesit" EXACT [] +xref: MetaCyc:PWY-5321 +is_a: GO:0016141 ! O-glycoside biosynthetic process +is_a: GO:0033302 ! quercetin O-glucoside metabolic process + +[Term] +id: GO:0033304 +name: chlorophyll a metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorophyll a." [ChEBI:18230, GOC:mah] +subset: gosubset_prok +synonym: "chlorophyll a metabolism" EXACT [] +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0033305 +name: chlorophyll a biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [ChEBI:18230, GOC:mah] +subset: gosubset_prok +synonym: "chlorophyll a anabolism" EXACT [] +synonym: "chlorophyll a biosynthesis" EXACT [] +synonym: "chlorophyll a formation" EXACT [] +synonym: "chlorophyll a synthesis" EXACT [] +is_a: GO:0015995 ! chlorophyll biosynthetic process +is_a: GO:0033304 ! chlorophyll a metabolic process + +[Term] +id: GO:0033306 +name: phytol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [ChEBI:17327, GOC:mah] +synonym: "phytol metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process + +[Term] +id: GO:0033307 +name: phytol salvage +namespace: biological_process +def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107] +synonym: "phytol salvage pathway" EXACT [] +xref: MetaCyc:PWY-5107 +is_a: GO:0033306 ! phytol metabolic process + +[Term] +id: GO:0033308 +name: hydroxyectoine transport +namespace: biological_process +def: "The directed movement of hydroxyectoine into, out of, within or between cells." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0033309 +name: SBF transcription complex +namespace: cellular_component +def: "A protein complex that acts as a transcription factor, composed of a regulatory subunit (Swi6) and a DNA-binding protein (Swi4), that activates gene expression during the G1/S transition of the cell cycle. Binds to a sequence motif called the SCB element (Swi4/6 cell cycle box, CACGAAA) which acts as a late Gl-specific UAS element in genes predominantly involved in budding, and in membrane and cell wall biosynthesis." [PMID:7917338] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0033310 +name: chlorophyll a catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [ChEBI:18230, GOC:mah] +subset: gosubset_prok +synonym: "chlorophyll a breakdown" EXACT [] +synonym: "chlorophyll a catabolism" EXACT [] +synonym: "chlorophyll a degradation" EXACT [] +xref: MetaCyc:PWY-5086 +xref: MetaCyc:PWY-5098 +is_a: GO:0015996 ! chlorophyll catabolic process +is_a: GO:0033304 ! chlorophyll a metabolic process + +[Term] +id: GO:0033311 +name: chlorophyll a biosynthetic process via phytyl diphosphate +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [ChEBI:18230, GOC:mah, MetaCyc:PWY-5086] +subset: gosubset_prok +synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT [] +synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT [] +synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT [] +synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT [] +synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT [] +xref: MetaCyc:PWY-5086 +is_a: GO:0033305 ! chlorophyll a biosynthetic process + +[Term] +id: GO:0033312 +name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [ChEBI:18230, GOC:mah, MetaCyc:PWY-5064] +subset: gosubset_prok +synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT [] +synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT [] +synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT [] +synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT [] +xref: MetaCyc:PWY-5064 +is_a: GO:0033305 ! chlorophyll a biosynthetic process + +[Term] +id: GO:0033313 +name: meiotic cell cycle checkpoint +namespace: biological_process +def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah] +is_a: GO:0000075 ! cell cycle checkpoint + +[Term] +id: GO:0033314 +name: mitotic cell cycle DNA replication checkpoint +namespace: biological_process +def: "A signal transduction based surveillance mechanism that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mah] +is_a: GO:0000076 ! DNA replication checkpoint +is_a: GO:0007093 ! mitotic cell cycle checkpoint + +[Term] +id: GO:0033315 +name: meiotic cell cycle DNA replication checkpoint +namespace: biological_process +def: "A signal transduction based surveillance mechanism that acts during a meiotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the haploid genome." [GOC:mah] +is_a: GO:0000076 ! DNA replication checkpoint +is_a: GO:0033313 ! meiotic cell cycle checkpoint + +[Term] +id: GO:0033316 +name: meiotic spindle checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] +is_a: GO:0031577 ! spindle checkpoint + +[Term] +id: GO:0033317 +name: pantothenate biosynthetic process from valine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including valine." [GOC:mah, MetaCyc:PANTO-PWY, MetaCyc:PWY-3921] +synonym: "pantothenate anabolism from valine" EXACT [] +synonym: "pantothenate biosynthesis from valine" EXACT [] +synonym: "pantothenate formation from valine" EXACT [] +synonym: "pantothenate synthesis from valine" EXACT [] +xref: MetaCyc:PANTO-PWY +xref: MetaCyc:PWY-3921 +is_a: GO:0015940 ! pantothenate biosynthetic process + +[Term] +id: GO:0033318 +name: pantothenate biosynthetic process from 2-oxypantoyl lactone +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including 2-oxypantoyl lactone." [GOC:mah, MetaCyc:PWY-3961] +synonym: "pantothenate anabolism from 2-oxypantoyl lactone" EXACT [] +synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" EXACT [] +synonym: "pantothenate formation from 2-oxypantoyl lactone" EXACT [] +synonym: "pantothenate synthesis from 2-oxypantoyl lactone" EXACT [] +xref: MetaCyc:PWY-3961 +is_a: GO:0015940 ! pantothenate biosynthetic process + +[Term] +id: GO:0033319 +name: UDP-D-xylose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-xylose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0042732 ! D-xylose metabolic process + +[Term] +id: GO:0033320 +name: UDP-D-xylose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821] +synonym: "UDP-D-xylose anabolism" EXACT [] +synonym: "UDP-D-xylose biosynthesis" EXACT [] +synonym: "UDP-D-xylose formation" EXACT [] +synonym: "UDP-D-xylose synthesis" EXACT [] +xref: MetaCyc:PWY-4821 +is_a: GO:0033319 ! UDP-D-xylose metabolic process +is_a: GO:0042842 ! D-xylose biosynthetic process + +[Term] +id: GO:0033321 +name: homomethionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] +synonym: "homomethionine metabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0033322 +name: homomethionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] +synonym: "homomethionine anabolism" EXACT [] +synonym: "homomethionine biosynthesis" EXACT [] +synonym: "homomethionine formation" EXACT [] +synonym: "homomethionine synthesis" EXACT [] +xref: MetaCyc:PWY-1186 +is_a: GO:0033321 ! homomethionine metabolic process + +[Term] +id: GO:0033323 +name: choline biosynthetic process via CDP-choline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561] +subset: gosubset_prok +synonym: "choline anabolism via CDP-choline" EXACT [] +synonym: "choline biosynthesis via CDP-choline" EXACT [] +synonym: "choline formation via CDP-choline" EXACT [] +synonym: "choline synthesis via CDP-choline" EXACT [] +xref: MetaCyc:PWY-3561 +xref: MetaCyc:PWY-4762 +is_a: GO:0042425 ! choline biosynthetic process + +[Term] +id: GO:0033324 +name: choline biosynthetic process via N-monomethylethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542] +subset: gosubset_prok +synonym: "choline anabolism via N-monomethylethanolamine" EXACT [] +synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT [] +synonym: "choline formation via N-monomethylethanolamine" EXACT [] +synonym: "choline synthesis via N-monomethylethanolamine" EXACT [] +xref: MetaCyc:PWY-3542 +xref: MetaCyc:PWY-4762 +is_a: GO:0042425 ! choline biosynthetic process + +[Term] +id: GO:0033325 +name: choline biosynthetic process via phosphoryl-ethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385] +subset: gosubset_prok +synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT [] +synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT [] +synonym: "choline formation via phosphoryl-ethanolamine" EXACT [] +synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT [] +xref: MetaCyc:PWY-3385 +xref: MetaCyc:PWY-4762 +is_a: GO:0042425 ! choline biosynthetic process + +[Term] +id: GO:0033326 +name: cerebrospinal fluid secretion +namespace: biological_process +def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451] +synonym: "CSF secretion" EXACT [] +is_a: GO:0007589 ! body fluid secretion + +[Term] +id: GO:0033327 +name: Leydig cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0033328 +name: peroxisome membrane targeting sequence binding +namespace: molecular_function +def: "Interacting selectively with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130] +synonym: "mPTS binding" EXACT [] +is_a: GO:0000268 ! peroxisome targeting sequence binding + +[Term] +id: GO:0033329 +name: kaempferol O-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [ChEBI:30200, GOC:mah, MetaCyc:PWY-5320] +synonym: "kaempferol O-glucoside metabolism" EXACT [] +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0033330 +name: kaempferol O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [ChEBI:30200, GOC:mah, MetaCyc:PWY-5320] +synonym: "kaempferol O-glucoside anabolism" EXACT [] +synonym: "kaempferol O-glucoside biosynthesis" EXACT [] +synonym: "kaempferol O-glucoside formation" EXACT [] +synonym: "kaempferol O-glucoside synthesit" EXACT [] +xref: MetaCyc:PWY-5320 +is_a: GO:0016141 ! O-glycoside biosynthetic process +is_a: GO:0033329 ! kaempferol O-glucoside metabolic process + +[Term] +id: GO:0033331 +name: ent-kaurene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] +subset: gosubset_prok +synonym: "ent-kaurene metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process + +[Term] +id: GO:0033332 +name: ent-kaurene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] +subset: gosubset_prok +synonym: "ent-kaurene anabolism" EXACT [] +synonym: "ent-kaurene biosynthesis" EXACT [] +synonym: "ent-kaurene formation" EXACT [] +synonym: "ent-kaurene synthesis" EXACT [] +xref: MetaCyc:PWY-5032 +xref: MetaCyc:PWY-5035 +xref: MetaCyc:PWY1F-141 +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0033331 ! ent-kaurene metabolic process + +[Term] +id: GO:0033333 +name: fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0048736 ! appendage development + +[Term] +id: GO:0033334 +name: fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a fin are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh] +is_a: GO:0035107 ! appendage morphogenesis +relationship: part_of GO:0033333 ! fin development + +[Term] +id: GO:0033335 +name: anal fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033338 ! medial fin development + +[Term] +id: GO:0033336 +name: caudal fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033338 ! medial fin development + +[Term] +id: GO:0033337 +name: dorsal fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033338 ! medial fin development + +[Term] +id: GO:0033338 +name: medial fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033333 ! fin development + +[Term] +id: GO:0033339 +name: pectoral fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033333 ! fin development + +[Term] +id: GO:0033340 +name: pelvic fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033333 ! fin development + +[Term] +id: GO:0033341 +name: regulation of collagen binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0033342 +name: negative regulation of collagen binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen binding." [GOC:mah] +synonym: "down regulation of collagen binding" EXACT [] +synonym: "down-regulation of collagen binding" EXACT [] +synonym: "downregulation of collagen binding" EXACT [] +synonym: "inhibition of collagen binding" NARROW [] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:0033341 ! regulation of collagen binding + +[Term] +id: GO:0033343 +name: positive regulation of collagen binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah] +synonym: "activation of collagen binding" NARROW [] +synonym: "stimulation of collagen binding" NARROW [] +synonym: "up regulation of collagen binding" EXACT [] +synonym: "up-regulation of collagen binding" EXACT [] +synonym: "upregulation of collagen binding" EXACT [] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:0033341 ! regulation of collagen binding + +[Term] +id: GO:0033344 +name: cholesterol efflux +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart] +synonym: "cholesterol export" EXACT [] +is_a: GO:0030301 ! cholesterol transport + +[Term] +id: GO:0033345 +name: asparagine catabolic process via L-aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] +xref: MetaCyc:ASPARAGINE-DEG1-PWY +xref: MetaCyc:PWY-4001 +is_a: GO:0006530 ! asparagine catabolic process + +[Term] +id: GO:0033346 +name: asparagine catabolic process via 2-oxosuccinamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002] +xref: MetaCyc:PWY-4002 +is_a: GO:0006530 ! asparagine catabolic process + +[Term] +id: GO:0033347 +name: tetrose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] +subset: gosubset_prok +synonym: "tetrose metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process + +[Term] +id: GO:0033348 +name: tetrose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] +synonym: "tetrose anabolism" EXACT [] +synonym: "tetrose biosynthesis" EXACT [] +synonym: "tetrose formation" EXACT [] +synonym: "tetrose synthesis" EXACT [] +is_a: GO:0033347 ! tetrose metabolic process + +[Term] +id: GO:0033349 +name: apiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [ChEBI:16689, GOC:mah] +synonym: "apiose metabolism" EXACT [] +is_a: GO:0033347 ! tetrose metabolic process + +[Term] +id: GO:0033350 +name: apiose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [ChEBI:16689, GOC:mah] +synonym: "apiose anabolism" EXACT [] +synonym: "apiose biosynthesis" EXACT [] +synonym: "apiose formation" EXACT [] +synonym: "apiose synthesis" EXACT [] +is_a: GO:0033348 ! tetrose biosynthetic process +is_a: GO:0033349 ! apiose metabolic process + +[Term] +id: GO:0033351 +name: UDP-D-apiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-apiose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0033349 ! apiose metabolic process + +[Term] +id: GO:0033352 +name: UDP-D-apiose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113] +synonym: "UDP-D-apiose anabolism" EXACT [] +synonym: "UDP-D-apiose biosynthesis" EXACT [] +synonym: "UDP-D-apiose formation" EXACT [] +synonym: "UDP-D-apiose synthesis" EXACT [] +xref: MetaCyc:PWY-4821 +xref: MetaCyc:PWY-5113 +is_a: GO:0033350 ! apiose biosynthetic process +is_a: GO:0033351 ! UDP-D-apiose metabolic process + +[Term] +id: GO:0033353 +name: S-adenosylmethionine cycle +namespace: biological_process +def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl moiety and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041] +synonym: "SAM cycle" EXACT [] +xref: MetaCyc:PWY-5041 +is_a: GO:0046500 ! S-adenosylmethionine metabolic process + +[Term] +id: GO:0033354 +name: chlorophyll cycle +namespace: biological_process +def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068] +xref: MetaCyc:PWY-5068 +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0033355 +name: ascorbate glutathione cycle +namespace: biological_process +def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261] +synonym: "hydrogen peroxide detoxification" RELATED [] +xref: MetaCyc:PWY-2261 +is_a: GO:0006749 ! glutathione metabolic process +is_a: GO:0019852 ! L-ascorbic acid metabolic process +is_a: GO:0042744 ! hydrogen peroxide catabolic process + +[Term] +id: GO:0033356 +name: UDP-L-arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-L-arabinose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0046373 ! L-arabinose metabolic process + +[Term] +id: GO:0033357 +name: L-arabinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [ChEBI:22599, GOC:mah] +synonym: "L-arabinose anabolism" EXACT [] +synonym: "L-arabinose biosynthesis" EXACT [] +synonym: "L-arabinose formation" EXACT [] +synonym: "L-arabinose synthesis" EXACT [] +is_a: GO:0033356 ! UDP-L-arabinose metabolic process + +[Term] +id: GO:0033358 +name: UDP-L-arabinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82] +synonym: "UDP-L-arabinose anabolism" EXACT [] +synonym: "UDP-L-arabinose biosynthesis" EXACT [] +synonym: "UDP-L-arabinose formation" EXACT [] +synonym: "UDP-L-arabinose synthesis" EXACT [] +xref: MetaCyc:PWY-63 +xref: MetaCyc:PWY-82 +is_a: GO:0033357 ! L-arabinose biosynthetic process + +[Term] +id: GO:0033359 +name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-] +subset: gosubset_prok +synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] +xref: MetaCyc:DAPLYSINESYN-PWY +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033360 +name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941] +subset: gosubset_prok +synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] +xref: MetaCyc:PWY-2941 +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033361 +name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, MetaCyc:PWY-2942] +subset: gosubset_prok +synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT [] +synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT [] +synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT [] +xref: MetaCyc:PWY-2942 +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033362 +name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, MetaCyc:PWY-5097] +subset: gosubset_prok +synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +xref: MetaCyc:PWY-5097 +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033363 +name: secretory granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] +synonym: "secretory granule organization and biogenesis" EXACT [] +is_a: GO:0016050 ! vesicle organization + +[Term] +id: GO:0033364 +name: mast cell secretory granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] +synonym: "mast cell secretory granule maturation" RELATED [] +synonym: "mast cell secretory granule organization and biogenesis" EXACT [] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0033365 +name: protein localization in organelle +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0033366 +name: protein localization in secretory granule +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] +is_a: GO:0033365 ! protein localization in organelle + +[Term] +id: GO:0033367 +name: protein localization in mast cell secretory granule +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] +is_a: GO:0033366 ! protein localization in secretory granule +relationship: part_of GO:0033364 ! mast cell secretory granule organization + +[Term] +id: GO:0033368 +name: protease localization in mast cell secretory granule +namespace: biological_process +def: "Any process by which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] +is_a: GO:0033367 ! protein localization in mast cell secretory granule + +[Term] +id: GO:0033369 +name: establishment of protein localization in mast cell secretory granule +namespace: biological_process +def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah] +is_a: GO:0006886 ! intracellular protein transport +relationship: part_of GO:0033367 ! protein localization in mast cell secretory granule + +[Term] +id: GO:0033370 +name: maintenance of protein location in mast cell secretory granule +namespace: biological_process +def: "A process by which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "mast cell protein retention" EXACT [] +is_a: GO:0045185 ! maintenance of protein location +relationship: part_of GO:0033367 ! protein localization in mast cell secretory granule + +[Term] +id: GO:0033371 +name: T cell secretory granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] +synonym: "T cell secretory granule organization and biogenesis" EXACT [] +synonym: "T lymphocyte secretory granule organization and biogenesis" EXACT [] +synonym: "T-cell secretory granule organization and biogenesis" EXACT [] +synonym: "T-lymphocyte secretory granule maturation" RELATED [] +synonym: "T-lymphocyte secretory granule organization and biogenesis" EXACT [] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0033372 +name: establishment of protease localization in mast cell secretory granule +namespace: biological_process +def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah] +is_a: GO:0033369 ! establishment of protein localization in mast cell secretory granule +relationship: part_of GO:0033368 ! protease localization in mast cell secretory granule + +[Term] +id: GO:0033373 +name: maintenance of protease location in mast cell secretory granule +namespace: biological_process +def: "A process by which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "mast cell protease retention" EXACT [] +is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule +relationship: part_of GO:0033368 ! protease localization in mast cell secretory granule + +[Term] +id: GO:0033374 +name: protein localization in T cell secretory granule +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] +synonym: "protein localization in T lymphocyte secretory granule" EXACT [] +synonym: "protein localization in T-cell secretory granule" EXACT [] +synonym: "protein localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033366 ! protein localization in secretory granule +relationship: part_of GO:0033371 ! T cell secretory granule organization + +[Term] +id: GO:0033375 +name: protease localization in T cell secretory granule +namespace: biological_process +def: "Any process by which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] +synonym: "protease localization in T lymphocyte secretory granule" EXACT [] +synonym: "protease localization in T-cell secretory granule" EXACT [] +synonym: "protease localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033374 ! protein localization in T cell secretory granule + +[Term] +id: GO:0033376 +name: establishment of protein localization in T cell secretory granule +namespace: biological_process +def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah] +synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT [] +synonym: "establishment of protein localization in T-cell secretory granule" EXACT [] +synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +relationship: part_of GO:0033374 ! protein localization in T cell secretory granule + +[Term] +id: GO:0033377 +name: maintenance of protein location in T cell secretory granule +namespace: biological_process +def: "A process by which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT [] +synonym: "maintenance of protein localization in T-cell secretory granule" EXACT [] +synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0045185 ! maintenance of protein location +relationship: part_of GO:0033374 ! protein localization in T cell secretory granule + +[Term] +id: GO:0033378 +name: establishment of protease localization in T cell secretory granule +namespace: biological_process +def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah] +synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT [] +synonym: "establishment of protease localization in T-cell secretory granule" EXACT [] +synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033376 ! establishment of protein localization in T cell secretory granule +relationship: part_of GO:0033375 ! protease localization in T cell secretory granule + +[Term] +id: GO:0033379 +name: maintenance of protease location in T cell secretory granule +namespace: biological_process +def: "A process by which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT [] +synonym: "maintenance of protease localization in T-cell secretory granule" EXACT [] +synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule +relationship: part_of GO:0033375 ! protease localization in T cell secretory granule + +[Term] +id: GO:0033380 +name: granzyme B localization in T cell secretory granule +namespace: biological_process +def: "Any process by which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] +synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT [] +synonym: "granzyme B localization in T-cell secretory granule" EXACT [] +synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033375 ! protease localization in T cell secretory granule + +[Term] +id: GO:0033381 +name: establishment of granzyme B localization in T cell secretory granule +namespace: biological_process +def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah] +synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT [] +synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT [] +synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT [] +synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED [] +is_a: GO:0033378 ! establishment of protease localization in T cell secretory granule +relationship: part_of GO:0033380 ! granzyme B localization in T cell secretory granule + +[Term] +id: GO:0033382 +name: maintenance of granzyme B location in T cell secretory granule +namespace: biological_process +def: "A process by which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah] +synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT [] +synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT [] +synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule +relationship: part_of GO:0033380 ! granzyme B localization in T cell secretory granule + +[Term] +id: GO:0033383 +name: geranyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122] +synonym: "geranyl diphosphate metabolism" EXACT [] +synonym: "geranyldiphosphate metabolic process" EXACT [] +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0033384 +name: geranyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122] +synonym: "geranyl diphosphate anabolism" EXACT [] +synonym: "geranyl diphosphate biosynthesis" EXACT [] +synonym: "geranyl diphosphate formation" EXACT [] +synonym: "geranyl diphosphate synthesis" EXACT [] +synonym: "geranyldiphosphate biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5122 +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0033383 ! geranyl diphosphate metabolic process + +[Term] +id: GO:0033385 +name: geranylgeranyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120] +synonym: "geranylgeranyl diphosphate metabolism" EXACT [] +synonym: "geranylgeranyldiphosphate metabolic process" EXACT [] +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0033386 +name: geranylgeranyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120] +synonym: "geranylgeranyl diphosphate anabolism" EXACT [] +synonym: "geranylgeranyl diphosphate biosynthesis" EXACT [] +synonym: "geranylgeranyl diphosphate formation" EXACT [] +synonym: "geranylgeranyl diphosphate synthesis" EXACT [] +synonym: "geranylvdiphosphate biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5120 +xref: MetaCyc:PWY-5121 +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process + +[Term] +id: GO:0033387 +name: putrescine biosynthetic process from ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] +synonym: "putrescine anabolism from ornithine" EXACT [] +synonym: "putrescine biosynthesis from ornithine" EXACT [] +synonym: "putrescine formation from ornithine" EXACT [] +synonym: "putrescine synthesis from ornithine" EXACT [] +is_a: GO:0009446 ! putrescine biosynthetic process + +[Term] +id: GO:0033388 +name: putrescine biosynthetic process from arginine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46] +subset: gosubset_prok +synonym: "putrescine anabolism from arginine" EXACT [] +synonym: "putrescine biosynthesis from arginine" EXACT [] +synonym: "putrescine formation from arginine" EXACT [] +synonym: "putrescine synthesis from arginine" EXACT [] +is_a: GO:0009446 ! putrescine biosynthetic process + +[Term] +id: GO:0033389 +name: putrescine biosynthetic process from arginine, using agmatinase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40] +subset: gosubset_prok +synonym: "putrescine anabolism from arginine, using agmatinase" EXACT [] +synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT [] +synonym: "putrescine formation from arginine, using agmatinase" EXACT [] +synonym: "putrescine synthesis from arginine, using agmatinase" EXACT [] +is_a: GO:0033388 ! putrescine biosynthetic process from arginine + +[Term] +id: GO:0033390 +name: putrescine biosynthetic process from arginine via N-carbamoylputrescine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43] +subset: gosubset_prok +synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT [] +synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT [] +synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT [] +synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT [] +is_a: GO:0033388 ! putrescine biosynthetic process from arginine + +[Term] +id: GO:0033391 +name: chromatoid body +namespace: cellular_component +def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363] +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0033392 +name: actin homodimerization activity +namespace: molecular_function +def: "Interacting selectively with an identical actin monomer to form a homodimer." [GOC:mah] +subset: gosubset_prok +synonym: "actin dimerization activity" BROAD [] +synonym: "actin polymerizing activity" RELATED [] +is_a: GO:0042803 ! protein homodimerization activity + +[Term] +id: GO:0033393 +name: homogalacturonan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah] +subset: gosubset_prok +synonym: "homogalacturonan breakdown" EXACT [] +synonym: "homogalacturonan catabolism" EXACT [] +synonym: "homogalacturonan degradation" EXACT [] +xref: MetaCyc:PWY-1081 +is_a: GO:0045490 ! pectin catabolic process + +[Term] +id: GO:0033394 +name: beta-alanine biosynthetic process via 1,3 diaminopropane +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981] +synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT [] +synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT [] +synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT [] +synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT [] +xref: MetaCyc:PWY-3981 +is_a: GO:0019483 ! beta-alanine biosynthetic process + +[Term] +id: GO:0033395 +name: beta-alanine biosynthetic process via 3-hydroxypropionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941] +synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT [] +synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT [] +synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT [] +synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT [] +xref: MetaCyc:PWY-3941 +is_a: GO:0019483 ! beta-alanine biosynthetic process + +[Term] +id: GO:0033396 +name: beta-alanine biosynthetic process via 3-ureidopropionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982] +synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT [] +synonym: "beta-alanine formation via 3-ureidopropionate" EXACT [] +synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT [] +xref: MetaCyc:PWY-3982 +is_a: GO:0019483 ! beta-alanine biosynthetic process + +[Term] +id: GO:0033397 +name: zeatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:15333, GOC:mah] +synonym: "zeatin metabolism" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process + +[Term] +id: GO:0033398 +name: zeatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:15333, GOC:mah] +subset: gosubset_prok +synonym: "zeatin anabolism" EXACT [] +synonym: "zeatin biosynthesis" EXACT [] +synonym: "zeatin formation" EXACT [] +synonym: "zeatin synthesis" EXACT [] +is_a: GO:0009691 ! cytokinin biosynthetic process +is_a: GO:0033397 ! zeatin metabolic process + +[Term] +id: GO:0033399 +name: cis-zeatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:12800, GOC:mah] +synonym: "cis-zeatin metabolism" EXACT [] +is_a: GO:0033397 ! zeatin metabolic process + +[Term] +id: GO:0033400 +name: trans-zeatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:16522, GOC:mah] +synonym: "trans-zeatin metabolism" EXACT [] +is_a: GO:0033397 ! zeatin metabolic process + +[Term] +id: GO:0033401 +name: TTT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TTT codon." [GOC:mah] +comment: Note that in the standard genetic code, TTT codes for phenylalanine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033402 +name: TTC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TTC codon." [GOC:mah] +comment: Note that in the standard genetic code, TTC codes for phenylalanine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033403 +name: TTA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TTA codon." [GOC:mah] +comment: Note that in the standard genetic code, TTA codes for leucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033404 +name: TTG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TTG codon." [GOC:mah] +comment: Note that in the standard genetic code, TTG codes for leucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033405 +name: TCT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TCT codon." [GOC:mah] +comment: Note that in the standard genetic code, TCT codes for serine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033406 +name: TCC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TCC codon." [GOC:mah] +comment: Note that in the standard genetic code, TCC codes for serine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033407 +name: TCA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TCA codon." [GOC:mah] +comment: Note that in the standard genetic code, TCA codes for serine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033408 +name: TCG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TCG codon." [GOC:mah] +comment: Note that in the standard genetic code, TCG codes for serine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033409 +name: TAT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TAT codon." [GOC:mah] +comment: Note that in the standard genetic code, TAT codes for tyrosine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033410 +name: TAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TAC codon." [GOC:mah] +comment: Note that in the standard genetic code, TAC codes for tyrosine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033411 +name: TAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TAA codon." [GOC:mah] +comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033412 +name: TAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TAG codon." [GOC:mah] +comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033413 +name: TGT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TGT codon." [GOC:mah] +comment: Note that in the standard genetic code, TGT codes for cysteine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033414 +name: TGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TGC codon." [GOC:mah] +comment: Note that in the standard genetic code, TGC codes for cysteine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033415 +name: TGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TGA codon." [GOC:mah] +comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033416 +name: TGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a TGG codon." [GOC:mah] +comment: Note that in the standard genetic code, TGG codes for tryptophan. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033417 +name: CTT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CTT codon." [GOC:mah] +comment: Note that in the standard genetic code, CTT codes for leucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033418 +name: CTC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CTC codon." [GOC:mah] +comment: Note that in the standard genetic code, CTC codes for leucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033419 +name: CTA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CTA codon." [GOC:mah] +comment: Note that in the standard genetic code, CTA codes for leucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033420 +name: CTG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CTG codon." [GOC:mah] +comment: Note that in the standard genetic code, CTG codes for leucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033421 +name: CCT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCT codon." [GOC:mah] +comment: Note that in the standard genetic code, CCT codes for proline. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033422 +name: CCC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah] +comment: Note that in the standard genetic code, CCC codes for proline. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033423 +name: CCA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah] +comment: Note that in the standard genetic code, CCA codes for proline. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033424 +name: CCG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah] +comment: Note that in the standard genetic code, CCG codes for proline. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033425 +name: CAT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAT codon." [GOC:mah] +comment: Note that in the standard genetic code, CAT codes for histidine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033426 +name: CAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah] +comment: Note that in the standard genetic code, CAC codes for histidine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033427 +name: CAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah] +comment: Note that in the standard genetic code, CAA codes for glutamine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033428 +name: CAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah] +comment: Note that in the standard genetic code, CAG codes for glutamine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033429 +name: CGT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGT codon." [GOC:mah] +comment: Note that in the standard genetic code, CGT codes for arginine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033430 +name: CGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah] +comment: Note that in the standard genetic code, CGC codes for arginine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033431 +name: CGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah] +comment: Note that in the standard genetic code, CGA codes for arginine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033432 +name: CGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah] +comment: Note that in the standard genetic code, CGG codes for arginine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033433 +name: ATT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ATT codon." [GOC:mah] +comment: Note that in the standard genetic code, ATT codes for isoleucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033434 +name: ATC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ATC codon." [GOC:mah] +comment: Note that in the standard genetic code, ATC codes for isoleucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033435 +name: ATA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ATA codon." [GOC:mah] +comment: Note that in the standard genetic code, ATA codes for isoleucine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033436 +name: ATG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ATG codon." [GOC:mah] +comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033437 +name: ACT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACT codon." [GOC:mah] +comment: Note that in the standard genetic code, ACT codes for threonine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033438 +name: ACC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah] +comment: Note that in the standard genetic code, ACC codes for threonine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033439 +name: ACA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah] +comment: Note that in the standard genetic code, ACA codes for threonine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033440 +name: ACG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah] +comment: Note that in the standard genetic code, ACG codes for threonine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033441 +name: AAT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAT codon." [GOC:mah] +comment: Note that in the standard genetic code, AAT codes for asparagine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033442 +name: AAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah] +comment: Note that in the standard genetic code, AAC codes for asparagine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033443 +name: AAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah] +comment: Note that in the standard genetic code, AAA codes for lysine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033444 +name: AAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah] +comment: Note that in the standard genetic code, AAG codes for lysine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033445 +name: AGT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGT codon." [GOC:mah] +comment: Note that in the standard genetic code, AGT codes for serine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033446 +name: AGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah] +comment: Note that in the standard genetic code, AGC codes for serine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033447 +name: AGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah] +comment: Note that in the standard genetic code, AGA codes for arginine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033448 +name: AGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah] +comment: Note that in the standard genetic code, AGG codes for arginine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033449 +name: GTT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GTT codon." [GOC:mah] +comment: Note that in the standard genetic code, GTT codes for valine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033450 +name: GTC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GTC codon." [GOC:mah] +comment: Note that in the standard genetic code, GTC codes for valine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033451 +name: GTA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GTA codon." [GOC:mah] +comment: Note that in the standard genetic code, GTA codes for valine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033452 +name: GTG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GTG codon." [GOC:mah] +comment: Note that in the standard genetic code, GTG codes for valine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033453 +name: GCT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCT codon." [GOC:mah] +comment: Note that in the standard genetic code, GCT codes for alanine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033454 +name: GCC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah] +comment: Note that in the standard genetic code, GCC codes for alanine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033455 +name: GCA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah] +comment: Note that in the standard genetic code, GCA codes for alanine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033456 +name: GCG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah] +comment: Note that in the standard genetic code, GCG codes for alanine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033457 +name: GAT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAT codon." [GOC:mah] +comment: Note that in the standard genetic code, GAT codes for acid. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033458 +name: GAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah] +comment: Note that in the standard genetic code, GAC codes for acid. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033459 +name: GAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah] +comment: Note that in the standard genetic code, GAA codes for acid. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033460 +name: GAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah] +comment: Note that in the standard genetic code, GAG codes for acid. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033461 +name: GGT codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGT codon." [GOC:mah] +comment: Note that in the standard genetic code, GGT codes for glycine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033462 +name: GGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah] +comment: Note that in the standard genetic code, GGC codes for glycine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033463 +name: GGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah] +comment: Note that in the standard genetic code, GGA codes for glycine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033464 +name: GGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah] +comment: Note that in the standard genetic code, GGG codes for glycine. +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033465 +name: cis-zeatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:12800, GOC:mah] +subset: gosubset_prok +synonym: "cis-zeatin anabolism" EXACT [] +synonym: "cis-zeatin biosynthesis" EXACT [] +synonym: "cis-zeatin formation" EXACT [] +synonym: "cis-zeatin synthesis" EXACT [] +xref: MetaCyc:PWY-2781 +is_a: GO:0033398 ! zeatin biosynthetic process +is_a: GO:0033399 ! cis-zeatin metabolic process + +[Term] +id: GO:0033466 +name: trans-zeatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:16522, GOC:mah] +subset: gosubset_prok +synonym: "trans-zeatin anabolism" EXACT [] +synonym: "trans-zeatin biosynthesis" EXACT [] +synonym: "trans-zeatin formation" EXACT [] +synonym: "trans-zeatin synthesis" EXACT [] +xref: MetaCyc:PWY-2681 +is_a: GO:0033398 ! zeatin biosynthetic process +is_a: GO:0033400 ! trans-zeatin metabolic process + +[Term] +id: GO:0033467 +name: CMP-ketodeoxyoctanoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CMP-ketodeoxyoctanoate, a substance composed of 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] +synonym: "CMP-3-deoxy-D-manno-octulosonic acid metabolic process" EXACT [] +synonym: "CMP-KDO metabolic process" EXACT [] +synonym: "CMP-ketodeoxyoctanoate metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0046400 ! ketodeoxyoctanoate metabolic process + +[Term] +id: GO:0033468 +name: CMP-ketodeoxyoctanoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CMP-ketodeoxyoctanoate, a substance composed of 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] +subset: gosubset_prok +synonym: "CMP-3-deoxy-D-manno-octulosonic acid biosynthetic process" EXACT [] +synonym: "CMP-KDO biosynthesis" EXACT [] +synonym: "CMP-KDO biosynthetic process" EXACT [] +synonym: "CMP-ketodeoxyoctanoate anabolism" EXACT [] +synonym: "CMP-ketodeoxyoctanoate biosynthesis" EXACT [] +synonym: "CMP-ketodeoxyoctanoate formation" EXACT [] +synonym: "CMP-ketodeoxyoctanoate synthesis" EXACT [] +xref: MetaCyc:KDOSYN-PWY +xref: MetaCyc:PWY-1269 +xref: MetaCyc:PWY-5111 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019294 ! ketodeoxyoctanoate biosynthetic process +is_a: GO:0033467 ! CMP-ketodeoxyoctanoate metabolic process + +[Term] +id: GO:0033469 +name: gibberellin 12 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [ChEBI:30088, GOC:mah] +synonym: "GA12 metabolic process" EXACT [] +synonym: "gibberellin 12 metabolism" EXACT [] +synonym: "gibberellin A12 metabolic process" EXACT [] +is_a: GO:0009685 ! gibberellin metabolic process + +[Term] +id: GO:0033470 +name: gibberellin 12 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [ChEBI:30088, GOC:mah] +synonym: "GA12 biosynthetic process" EXACT [] +synonym: "gibberellin 12 anabolism" EXACT [] +synonym: "gibberellin 12 biosynthesis" EXACT [] +synonym: "gibberellin 12 formation" EXACT [] +synonym: "gibberellin 12 synthesis" EXACT [] +synonym: "gibberellin A12 biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5034 +is_a: GO:0009686 ! gibberellin biosynthetic process +is_a: GO:0033469 ! gibberellin 12 metabolic process + +[Term] +id: GO:0033471 +name: GDP-L-galactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] +synonym: "GDP-L-galactose metabolism" EXACT [] +is_a: GO:0006012 ! galactose metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033472 +name: GDP-L-galactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] +synonym: "GDP-L-galactose anabolism" EXACT [] +synonym: "GDP-L-galactose biosynthesis" EXACT [] +synonym: "GDP-L-galactose formation" EXACT [] +synonym: "GDP-L-galactose synthesis" EXACT [] +xref: MetaCyc:PWY-5115 +is_a: GO:0033471 ! GDP-L-galactose metabolic process + +[Term] +id: GO:0033473 +name: indoleacetic acid conjugate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] +synonym: "IAA conjugate metabolic process" EXACT [] +synonym: "indole acetic acid conjugate metabolic process" EXACT [] +synonym: "indole acetic acid conjugate metabolism" EXACT [] +synonym: "indoleacetic acid conjugate metabolism" EXACT [] +is_a: GO:0009683 ! indoleacetic acid metabolic process + +[Term] +id: GO:0033474 +name: indoleacetic acid conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] +synonym: "IAA conjugate biosynthetic process" EXACT [] +synonym: "indole acetic acid conjugate biosynthesis" EXACT [] +synonym: "indole acetic acid conjugate biosynthetic process" EXACT [] +synonym: "indoleacetic acid conjugate anabolism" EXACT [] +synonym: "indoleacetic acid conjugate biosynthesis" EXACT [] +synonym: "indoleacetic acid conjugate formation" EXACT [] +synonym: "indoleacetic acid conjugate synthesis" EXACT [] +is_a: GO:0009851 ! auxin biosynthetic process +is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process +is_a: GO:0042435 ! indole derivative biosynthetic process + +[Term] +id: GO:0033475 +name: indoleacetic acid amide conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782] +synonym: "IAA amide conjugate biosynthetic process" EXACT [] +synonym: "indole acetic acid amide conjugate biosynthesis" EXACT [] +synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT [] +synonym: "indoleacetic acid amide conjugate anabolism" EXACT [] +synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT [] +synonym: "indoleacetic acid amide conjugate formation" EXACT [] +synonym: "indoleacetic acid amide conjugate synthesis" EXACT [] +xref: MetaCyc:PWY-1782 +is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process + +[Term] +id: GO:0033476 +name: indoleacetic acid ester conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741] +synonym: "IAA ester conjugate biosynthetic process" EXACT [] +synonym: "indole acetic acid ester conjugate biosynthesis" EXACT [] +synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT [] +synonym: "indoleacetic acid ester conjugate anabolism" EXACT [] +synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT [] +synonym: "indoleacetic acid ester conjugate formation" EXACT [] +synonym: "indoleacetic acid ester conjugate synthesis" EXACT [] +xref: MetaCyc:PWY-1741 +is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process + +[Term] +id: GO:0033477 +name: S-methylmethionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340] +synonym: "S-methylmethionine metabolism" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0033478 +name: UDP-rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748] +synonym: "UDP-rhamnose metabolism" EXACT [] +xref: MetaCyc:PWY-3261 +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0019299 ! rhamnose metabolic process + +[Term] +id: GO:0033479 +name: UDP-D-galacturonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-galacturonate metabolism" EXACT [] +is_a: GO:0046396 ! D-galacturonate metabolic process + +[Term] +id: GO:0033480 +name: UDP-D-galacturonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-galacturonate anabolism" EXACT [] +synonym: "UDP-D-galacturonate biosynthesis" EXACT [] +synonym: "UDP-D-galacturonate formation" EXACT [] +synonym: "UDP-D-galacturonate synthesis" EXACT [] +xref: MetaCyc:PWY-4 +is_a: GO:0033479 ! UDP-D-galacturonate metabolic process +is_a: GO:0033482 ! D-galacturonate biosynthetic process + +[Term] +id: GO:0033481 +name: galacturonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah] +synonym: "galacturonate anabolism" EXACT [] +synonym: "galacturonate biosynthesis" EXACT [] +synonym: "galacturonate formation" EXACT [] +synonym: "galacturonate synthesis" EXACT [] +is_a: GO:0019586 ! galacturonate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0033482 +name: D-galacturonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the dextrorotatory isomer of galacturonate, the anion of galacturonic acid." [GOC:mah] +synonym: "D-galacturonate anabolism" EXACT [] +synonym: "D-galacturonate biosynthesis" EXACT [] +synonym: "D-galacturonate formation" EXACT [] +synonym: "D-galacturonate synthesis" EXACT [] +is_a: GO:0033481 ! galacturonate biosynthetic process +is_a: GO:0046396 ! D-galacturonate metabolic process + +[Term] +id: GO:0033483 +name: gas homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium of a gas within an organism or cell." [GOC:mah] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0033484 +name: nitric oxide homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium of nitric oxide within an organism or cell." [GOC:mah] +synonym: "NO homeostasis" EXACT [] +is_a: GO:0033483 ! gas homeostasis + +[Term] +id: GO:0033485 +name: cyanidin 3-O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] +synonym: "cyanidin 3-O-glucoside anabolism" EXACT [] +synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT [] +synonym: "cyanidin 3-O-glucoside formation" EXACT [] +synonym: "cyanidin 3-O-glucoside synthesis" EXACT [] +xref: MetaCyc:PWY-5125 +is_a: GO:0009718 ! anthocyanin biosynthetic process +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0033486 +name: delphinidin 3-O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153] +synonym: "delphinidin 3-O-glucoside anabolism" EXACT [] +synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT [] +synonym: "delphinidin 3-O-glucoside formation" EXACT [] +synonym: "delphinidin 3-O-glucoside synthesis" EXACT [] +xref: MetaCyc:PWY-5153 +is_a: GO:0009718 ! anthocyanin biosynthetic process +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0033487 +name: pelargonidin 3-O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] +synonym: "pelargonidin 3-O-glucoside anabolism" EXACT [] +synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT [] +synonym: "pelargonidin 3-O-glucoside formation" EXACT [] +synonym: "pelargonidin 3-O-glucoside synthesis" EXACT [] +xref: MetaCyc:PWY-5125 +is_a: GO:0009718 ! anthocyanin biosynthetic process +is_a: GO:0016140 ! O-glycoside metabolic process + +[Term] +id: GO:0033488 +name: cholesterol biosynthetic process via 24,25-dihydrolanosterol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3] +synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT [] +synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT [] +synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT [] +synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT [] +xref: MetaCyc:PWY66-3 +is_a: GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0033489 +name: cholesterol biosynthetic process via desmosterol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4] +synonym: "cholesterol anabolism via desmosterol" EXACT [] +synonym: "cholesterol biosynthesis via desmosterol" EXACT [] +synonym: "cholesterol formation via desmosterol" EXACT [] +synonym: "cholesterol synthesis via desmosterol" EXACT [] +xref: MetaCyc:PWY66-4 +is_a: GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0033490 +name: cholesterol biosynthetic process via lathosterol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341] +synonym: "cholesterol anabolism via lathosterol" EXACT [] +synonym: "cholesterol biosynthesis via lathosterol" EXACT [] +synonym: "cholesterol formation via lathosterol" EXACT [] +synonym: "cholesterol synthesis via lathosterol" EXACT [] +xref: MetaCyc:PWY66-341 +is_a: GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0033491 +name: coniferin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [ChEBI:16220, GOC:mah, MetaCyc:PWY-116] +synonym: "coniferin metabolism" EXACT [] +xref: MetaCyc:PWY-116 +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0033492 +name: esculetin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah] +synonym: "esculetin metabolism" EXACT [] +is_a: GO:0009804 ! coumarin metabolic process + +[Term] +id: GO:0033493 +name: esculetin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah] +synonym: "esculetin anabolism" EXACT [] +synonym: "esculetin biosynthesis" EXACT [] +synonym: "esculetin formation" EXACT [] +synonym: "esculetin synthesis" EXACT [] +xref: MetaCyc:PWY-5349 +is_a: GO:0009805 ! coumarin biosynthetic process +is_a: GO:0033492 ! esculetin metabolic process + +[Term] +id: GO:0033494 +name: ferulate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [ChEBI:29749, GOC:mah] +synonym: "ferulate metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0033495 +name: ferulate biosythetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [ChEBI:29749, GOC:mah] +synonym: "ferulate anabolism" EXACT [] +synonym: "ferulate biosynthesis" EXACT [] +synonym: "ferulate formation" EXACT [] +synonym: "ferulate synthesis" EXACT [] +xref: MetaCyc:PWY-5168 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0033494 ! ferulate metabolic process + +[Term] +id: GO:0033496 +name: sinapate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah] +synonym: "sinapate metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0033497 +name: sinapate biosythetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah] +synonym: "sinapate anabolism" EXACT [] +synonym: "sinapate biosynthesis" EXACT [] +synonym: "sinapate formation" EXACT [] +synonym: "sinapate synthesis" EXACT [] +xref: MetaCyc:PWY-5168 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0033496 ! sinapate metabolic process + +[Term] +id: GO:0033498 +name: galactose catabolic process via D-galactonate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY] +subset: gosubset_prok +synonym: "galactose breakdown via D-galactonate" EXACT [] +synonym: "galactose catabolism via D-galactonate" EXACT [] +synonym: "galactose degradation via D-galactonate" EXACT [] +xref: MetaCyc:GALDEG-PWY +is_a: GO:0019388 ! galactose catabolic process + +[Term] +id: GO:0033499 +name: galactose catabolic process via UDP-galactose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821] +synonym: "galactose breakdown via UDP-galactose" EXACT [] +synonym: "galactose catabolism via UDP-galactose" EXACT [] +synonym: "galactose degradation via UDP-galactose" EXACT [] +xref: MetaCyc:PWY-3821 +is_a: GO:0019388 ! galactose catabolic process + +[Term] +id: GO:0033500 +name: carbohydrate homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium of a carbohydrate within an organism or cell." [GOC:mah] +subset: gosubset_prok +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0033501 +name: galactose homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium of galactose within an organism or cell." [GOC:mah] +is_a: GO:0033500 ! carbohydrate homeostasis + +[Term] +id: GO:0033502 +name: cellular galactose homeostasis +namespace: biological_process +def: "A cellular homeostatic process involved in the maintenance of an internal equilibrium of galactose within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] +subset: gosubset_prok +synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042593 ! glucose homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0033503 +name: HULC complex +namespace: cellular_component +def: "A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714] +is_a: GO:0000151 ! ubiquitin ligase complex +is_a: GO:0031371 ! ubiquitin conjugating enzyme complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000792 ! heterochromatin + +[Term] +id: GO:0033504 +name: floor plate development +namespace: biological_process +def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0033505 +name: floor plate morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the floor plate is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dh] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0033504 ! floor plate development + +[Term] +id: GO:0033506 +name: glucosinolate biosynthetic process from homomethionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187] +subset: gosubset_prok +synonym: "glucosinolate anabolism from homomethionine" EXACT [] +synonym: "glucosinolate biosynthesis from homomethionine" EXACT [] +synonym: "glucosinolate formation from homomethionine" EXACT [] +synonym: "glucosinolate synthesis from homomethionine" EXACT [] +xref: MetaCyc:PWY-1187 +is_a: GO:0019761 ! glucosinolate biosynthetic process + +[Term] +id: GO:0033507 +name: glucosinolate biosynthetic process from phenylalanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821] +subset: gosubset_prok +synonym: "glucosinolate anabolism from phenylalanine" EXACT [] +synonym: "glucosinolate biosynthesis from phenylalanine" EXACT [] +synonym: "glucosinolate formation from phenylalanine" EXACT [] +synonym: "glucosinolate synthesis from phenylalanine" EXACT [] +xref: MetaCyc:PWY-2821 +is_a: GO:0019761 ! glucosinolate biosynthetic process + +[Term] +id: GO:0033508 +name: glutamate catabolic process to butyrate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087] +subset: gosubset_prok +synonym: "glutamate breakdown to butyrate" EXACT [] +synonym: "glutamate degradation to butyrate" EXACT [] +xref: MetaCyc:PWY-5087 +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:0033509 +name: glutamate catabolic process to propionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088] +subset: gosubset_prok +synonym: "glutamate breakdown to propionate" EXACT [] +synonym: "glutamate degradation to propionate" EXACT [] +xref: MetaCyc:PWY-5088 +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0033510 +name: luteolin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [ChEBI:15864, GOC:mah] +synonym: "luteolin metabolism" EXACT [] +is_a: GO:0051552 ! flavone metabolic process + +[Term] +id: GO:0033511 +name: luteolin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [ChEBI:15864, GOC:mah] +synonym: "luteolin anabolism" EXACT [] +synonym: "luteolin biosynthesis" EXACT [] +synonym: "luteolin formation" EXACT [] +synonym: "luteolin synthesis" EXACT [] +xref: MetaCyc:PWY-5060 +is_a: GO:0033510 ! luteolin metabolic process +is_a: GO:0051553 ! flavone biosynthetic process + +[Term] +id: GO:0033512 +name: L-lysine catabolic process to acetyl-CoA via saccharopine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY] +subset: gosubset_prok +synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT [] +xref: MetaCyc:LYSINE-DEG1-PWY +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033513 +name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280] +subset: gosubset_prok +synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT [] +xref: MetaCyc:PWY-5280 +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033514 +name: L-lysine catabolic process to acetyl-CoA via L-pipecolate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283] +subset: gosubset_prok +synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT [] +xref: MetaCyc:PWY-5283 +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033515 +name: L-lysine catabolic process using lysine 6-aminotransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298] +subset: gosubset_prok +synonym: "L-lysine breakdown to acetyl-CoA " EXACT [] +synonym: "L-lysine degradation to acetyl-CoA " EXACT [] +xref: MetaCyc:PWY-5298 +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033516 +name: methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702] +subset: gosubset_prok +synonym: "methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [] +synonym: "methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [] +synonym: "methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [] +xref: MetaCyc:PWY-702 +is_a: GO:0019279 ! methionine biosynthetic process from L-homoserine via cystathionine + +[Term] +id: GO:0033517 +name: myo-inositol hexakisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [ChEBI:17401, PMID:16107538] +synonym: "myo-inositol hexakisphosphate metabolism" EXACT [] +synonym: "phytate metabolic process" EXACT [] +synonym: "phytate metabolism" EXACT [] +is_a: GO:0043647 ! inositol phosphate metabolic process + +[Term] +id: GO:0033518 +name: myo-inositol hexakisphosphate dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah] +synonym: "phytate dephosphorylation" EXACT [] +xref: MetaCyc:PWY-4702 +xref: MetaCyc:PWY-4781 +is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process +is_a: GO:0046855 ! inositol phosphate dephosphorylation + +[Term] +id: GO:0033519 +name: phytyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [ChEBI:18187, GOC:mah] +synonym: "phytyl diphosphate metabolism" EXACT [] +is_a: GO:0033306 ! phytol metabolic process + +[Term] +id: GO:0033520 +name: phytol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [ChEBI:17327, GOC:mah] +synonym: "phytol anabolism" EXACT [] +synonym: "phytol biosynthesis" EXACT [] +synonym: "phytol formation" EXACT [] +synonym: "phytol synthesis" EXACT [] +is_a: GO:0033306 ! phytol metabolic process + +[Term] +id: GO:0033521 +name: phytyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [ChEBI:18187, GOC:mah] +synonym: "phytyl diphosphate anabolism" EXACT [] +synonym: "phytyl diphosphate biosynthesis" EXACT [] +synonym: "phytyl diphosphate formation" EXACT [] +synonym: "phytyl diphosphate synthesis" EXACT [] +xref: MetaCyc:PWY-5063 +is_a: GO:0033519 ! phytyl diphosphate metabolic process +is_a: GO:0033520 ! phytol biosynthetic process + +[Term] +id: GO:0033522 +name: histone H2A ubiquitination +namespace: biological_process +def: "The modification of histone H2A by addition of ubiquitin groups. Modification occurs at lysine 119 (H2A-K119) of metazoans or the equivalent residue." [GOC:mah, PMID:15509584, PMID:16473935] +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033523 +name: histone H2B ubiquitination +namespace: biological_process +def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah] +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033524 +name: sinapate ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah] +synonym: "sinapate ester metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0033525 +name: sinapate ester biosythetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah] +synonym: "sinapate ester anabolism" EXACT [] +synonym: "sinapate ester biosynthesis" EXACT [] +synonym: "sinapate ester formation" EXACT [] +synonym: "sinapate ester synthesis" EXACT [] +xref: MetaCyc:PWY-3301 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0033524 ! sinapate ester metabolic process + +[Term] +id: GO:0033526 +name: tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [ChEBI:26932, GOC:mah, MetaCyc:PWY-5188] +synonym: "tetrapyrrole anabolism from glutamate" EXACT [] +synonym: "tetrapyrrole biosynthesis from glutamate" EXACT [] +synonym: "tetrapyrrole formation from glutamate" EXACT [] +synonym: "tetrapyrrole synthesis from glutamate" EXACT [] +xref: MetaCyc:PWY-5188 +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0033527 +name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [ChEBI:26932, GOC:mah, MetaCyc:PWY-5189] +synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [] +synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [] +synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT [] +synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [] +xref: MetaCyc:PWY-5189 +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0033528 +name: S-methylmethionine cycle +namespace: biological_process +def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine moiety of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441] +xref: MetaCyc:PWY-5441 +is_a: GO:0033477 ! S-methylmethionine metabolic process + +[Term] +id: GO:0033529 +name: raffinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:16634, GOC:mah] +synonym: "raffinose anabolism" EXACT [] +synonym: "raffinose biosynthesis" EXACT [] +synonym: "raffinose formation" EXACT [] +synonym: "raffinose synthesis" EXACT [] +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033530 ! raffinose metabolic process + +[Term] +id: GO:0033530 +name: raffinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:16634, GOC:mah] +synonym: "raffinose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033531 +name: stachyose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:17164, GOC:mah] +synonym: "stachyose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033532 +name: stachyose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:17164, GOC:mah] +synonym: "stachyose anabolism" EXACT [] +synonym: "stachyose biosynthesis" EXACT [] +synonym: "stachyose formation" EXACT [] +synonym: "stachyose synthesis" EXACT [] +xref: MetaCyc:PWY-5337 +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033531 ! stachyose metabolic process + +[Term] +id: GO:0033533 +name: verbascose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] +synonym: "verbascose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033534 +name: verbascose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] +synonym: "verbascose anabolism" EXACT [] +synonym: "verbascose biosynthesis" EXACT [] +synonym: "verbascose formation" EXACT [] +synonym: "verbascose synthesis" EXACT [] +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033533 ! verbascose metabolic process + +[Term] +id: GO:0033535 +name: ajugose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] +synonym: "ajugose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033536 +name: ajugose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] +synonym: "ajugose anabolism" EXACT [] +synonym: "ajugose biosynthesis" EXACT [] +synonym: "ajugose formation" EXACT [] +synonym: "ajugose synthesis" EXACT [] +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033535 ! ajugose metabolic process + +[Term] +id: GO:0033537 +name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a ptahway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342] +synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT [] +synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT [] +synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT [] +synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT [] +xref: MetaCyc:PWY-5342 +is_a: GO:0033536 ! ajugose biosynthetic process + +[Term] +id: GO:0033538 +name: ajugose biosynthetic process using galactan:galactan galactosyltransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343] +synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT [] +synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT [] +synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT [] +synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT [] +xref: MetaCyc:PWY-5343 +is_a: GO:0033536 ! ajugose biosynthetic process + +[Term] +id: GO:0033539 +name: fatty acid beta-oxidation using acyl-CoA dehydrogenase +namespace: biological_process +def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed from oxidation pass through the respiratory chain to oxygen and leave H2O as the product." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136] +xref: MetaCyc:FAO-PWY +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033540 +name: fatty acid beta-oxidation using acyl-CoA oxidase +namespace: biological_process +def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed from oxidation pass directly to oxygen and produce H2O2, which is cleaved by peroxisomal catalases." [GOC:mah, MetaCyc:PWY-5136] +xref: MetaCyc:PWY-5136 +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033541 +name: fatty acid beta-oxidation, unsaturated, odd number +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation." [GOC:mah, MetaCyc:PWY-5137] +xref: MetaCyc:PWY-5137 +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033542 +name: fatty acid beta-oxidation, unsaturated, even number +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded." [GOC:mah, MetaCyc:PWY-5138] +xref: MetaCyc:PWY-5138 +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033543 +name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation." [GOC:mah, MetaCyc:PWY-5138] +is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number + +[Term] +id: GO:0033544 +name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway." [GOC:mah, MetaCyc:PWY-5138] +is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number + +[Term] +id: GO:0033545 +name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-4765] +synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT [] +synonym: "phytate biosynthesis, lipid-dependent" EXACT [] +synonym: "phytate biosynthetic process, lipid-dependent" EXACT [] +xref: MetaCyc:PWY-4765 +is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process + +[Term] +id: GO:0033546 +name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-4562] +synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT [] +xref: MetaCyc:PWY-4562 +is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent + +[Term] +id: GO:0033547 +name: myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541] +synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +xref: MetaCyc:PWY-4541 +is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent + +[Term] +id: GO:0033548 +name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661] +synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT [] +synonym: "phytate biosynthesis, lipid-independent" EXACT [] +synonym: "phytate biosynthetic process, lipid-independent" EXACT [] +xref: MetaCyc:PWY-4661 +is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process + +[Term] +id: GO:0033549 +name: MAP kinase phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah] +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0033550 +name: MAP kinase tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah] +synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT [] +is_a: GO:0004725 ! protein tyrosine phosphatase activity +is_a: GO:0033549 ! MAP kinase phosphatase activity + +[Term] +id: GO:0033551 +name: monopolin complex +namespace: cellular_component +def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824] +synonym: "monopolin subcomplex Csm1/Lrs4" NARROW [] +synonym: "Pcs1/Mde4 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000777 ! condensed chromosome kinetochore + +[Term] +id: GO:0033552 +name: response to vitamin B3 +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl] +synonym: "response to niacin" NARROW [] +synonym: "response to nicotinamide" NARROW [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033553 +name: rDNA heterochromatin +namespace: cellular_component +def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah] +synonym: "ribosomal DNA heterochromatin" EXACT [] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0033554 +name: cellular response to stress +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +is_a: GO:0006950 ! response to stress +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0033555 +name: multicellular organismal response to stress +namespace: biological_process +def: "A change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +is_a: GO:0006950 ! response to stress +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0033556 +name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995] +synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033557 +name: Slx1-Slx4 complex +namespace: cellular_component +def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part + +[Term] +id: GO:0033558 +name: protein deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah] +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0033559 +name: unsaturated fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah] +subset: gosubset_prok +synonym: "unsaturated fatty acid metabolism" EXACT [] +xref: MetaCyc:PWY-762 +xref: MetaCyc:PWY-782 +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0033560 +name: folate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pd] +subset: gosubset_prok +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033561 +name: regulation of water loss via skin +namespace: biological_process +def: "A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah] +synonym: "skin barrier function" RELATED [] +is_a: GO:0050891 ! multicellular organismal water homeostasis + +[Term] +id: GO:0033562 +name: cotranscriptional gene silencing by small RNA +namespace: biological_process +def: "A process by which the targeting of nascent transcripts by the RITS complex mediates chromatin modifications and promotes the degradation of nascent transcripts synthesized in heterochromatic regions." [GOC:mah, PMID:17512405] +synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0033563 +name: dorsal/ventral axon guidance +namespace: biological_process +def: "The process by which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb] +synonym: "dorsal-ventral axon guidance" EXACT [] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0033564 +name: anterior/posterior axon guidance +namespace: biological_process +def: "The process by which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb] +synonym: "anterior-posterior axon guidance" EXACT [] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0033565 +name: ESCRT-0 complex +namespace: cellular_component +def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868] +synonym: "Hrs/STAM complex" EXACT [] +synonym: "Vps27p-Hse1p complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044440 ! endosomal part + +[Term] +id: GO:0033566 +name: gamma-tubulin complex localization +namespace: biological_process +def: "Any process by which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT [] +is_a: GO:0034629 ! cellular protein complex localization + +[Term] +id: GO:0033567 +name: DNA replication, Okazaki fragment processing +namespace: biological_process +def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006273 ! lagging strand elongation + +[Term] +id: GO:0033568 +name: lactoferrin receptor activity +namespace: molecular_function +def: "Combining with lactoferrin to initiate a change in cell activity." [GOC:mlg] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0033569 +name: lactoferrin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] +is_a: GO:0015091 ! ferric iron transmembrane transporter activity +is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity + +[Term] +id: GO:0033570 +name: transferrin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of transferrin from one side of a membrane to the other." [GOC:mlg] +is_a: GO:0015091 ! ferric iron transmembrane transporter activity +is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity + +[Term] +id: GO:0033571 +name: lactoferrin transport +namespace: biological_process +def: "The directed movement of lactoferrin into, out of, within or between cells." [GOC:mlg] +is_a: GO:0015031 ! protein transport +is_a: GO:0015682 ! ferric iron transport + +[Term] +id: GO:0033572 +name: transferrin transport +namespace: biological_process +def: "The directed movement of transferrin into, out of, within or between cells." [GOC:mlg] +is_a: GO:0015031 ! protein transport +is_a: GO:0015682 ! ferric iron transport + +[Term] +id: GO:0033573 +name: high affinity iron permease complex +namespace: cellular_component +def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell." [GOC:jp, PMID:16522632, PMID:8599111] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0033574 +name: response to testosterone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl] +is_a: GO:0048545 ! response to steroid hormone stimulus + +[Term] +id: GO:0033575 +name: protein amino acid glycosylation at cell surface +namespace: biological_process +def: "The addition of a sugar unit to a protein amino acid at the surface of a cell." [GOC:mah, PMID:12042244] +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0033576 +name: protein amino acid glycosylation in cytosol +namespace: biological_process +def: "The addition of a sugar unit to a protein amino acid in the cytosol." [GOC:mah, PMID:12042244] +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0033577 +name: protein amino acid glycosylation in endoplasmic reticulum +namespace: biological_process +def: "The addition of a sugar unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, PMID:12042244] +synonym: "protein amino acid glycosylation in ER" EXACT [] +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0033578 +name: protein amino acid glycosylation in Golgi +namespace: biological_process +def: "The addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, PMID:12042244] +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0033579 +name: protein amino acid galactosylation in endoplasmic reticulum +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah] +synonym: "protein amino acid galactosylation in ER" EXACT [] +is_a: GO:0033577 ! protein amino acid glycosylation in endoplasmic reticulum +is_a: GO:0042125 ! protein amino acid galactosylation + +[Term] +id: GO:0033580 +name: protein amino acid galactosylation at cell surface +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah] +is_a: GO:0033575 ! protein amino acid glycosylation at cell surface +is_a: GO:0042125 ! protein amino acid galactosylation + +[Term] +id: GO:0033581 +name: protein amino acid galactosylation in Golgi +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah] +is_a: GO:0033578 ! protein amino acid glycosylation in Golgi +is_a: GO:0042125 ! protein amino acid galactosylation + +[Term] +id: GO:0033582 +name: protein amino acid galactosylation in cytosol +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah] +is_a: GO:0033576 ! protein amino acid glycosylation in cytosol +is_a: GO:0042125 ! protein amino acid galactosylation + +[Term] +id: GO:0033583 +name: rhabdomere membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0016028 ! rhabdomere + +[Term] +id: GO:0033584 +name: tyrosine biosynthetic process from chorismate via L-arogenate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah, MetaCyc:PWY-3461] +subset: gosubset_prok +synonym: "tyrosine anabolism from chorismate via L-arogenate" EXACT [] +synonym: "tyrosine formation from chorismate via L-arogenate" EXACT [] +synonym: "tyrosine synthesis from chorismate via L-arogenate" EXACT [] +xref: MetaCyc:PWY-3461 +is_a: GO:0006571 ! tyrosine biosynthetic process + +[Term] +id: GO:0033585 +name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT [] +synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT [] +synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT [] +synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT [] +xref: MetaCyc:PHESYN +is_a: GO:0009094 ! L-phenylalanine biosynthetic process + +[Term] +id: GO:0033586 +name: L-phenylalanine biosynthetic process from chorismate via L-arogenate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators] +subset: gosubset_prok +synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT [] +synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT [] +synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT [] +synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT [] +xref: MetaCyc:PWY-3462 +is_a: GO:0009094 ! L-phenylalanine biosynthetic process + +[Term] +id: GO:0033587 +name: shikimate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [ChEBI:36208, GOC:mah] +synonym: "shikimate anabolism" EXACT [] +synonym: "shikimate biosynthesis" EXACT [] +synonym: "shikimate formation" EXACT [] +synonym: "shikimate synthesis" EXACT [] +is_a: GO:0019632 ! shikimate metabolic process + +[Term] +id: GO:0033588 +name: Elongator holoenzyme complex +namespace: cellular_component +alt_id: GO:0033589 +def: "A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:mah, PMID:11689709, PMID:17018299] +synonym: "Elongator core complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0033590 +name: response to cobalamin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl] +synonym: "response to vitamin B12" EXACT [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033591 +name: response to L-ascorbic acid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl] +synonym: "response to ascorbic acid" BROAD [] +synonym: "response to L-ascorbate" EXACT [] +synonym: "response to vitamin C" EXACT [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033592 +name: RNA strand annealing activity +namespace: molecular_function +def: "Facilitates the base-pairing of complementary single-stranded RNA." [GOC:mah] +is_a: GO:0003725 ! double-stranded RNA binding +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0033593 +name: BRCA2-MAGE-D1 complex +namespace: cellular_component +def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0033594 +name: response to hydroxyisoflavone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [ChEBI:38755, GOC:mah] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0033595 +name: response to genistein +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [ChEBI:28088, GOC:mah] +is_a: GO:0014070 ! response to organic cyclic substance + +[Term] +id: GO:0033596 +name: TSC1-TSC2 complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671] +synonym: "tuberin-hamartin complex " EXACT [] +synonym: "tuberous sclerosis complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0033597 +name: mitotic checkpoint complex +namespace: cellular_component +def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307] +synonym: "MCC" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0033598 +name: mammary gland epithelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0033599 +name: regulation of mammary gland epithelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation + +[Term] +id: GO:0033600 +name: negative regulation of mammary gland epithelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] +synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW [] +is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation + +[Term] +id: GO:0033601 +name: positive regulation of mammary gland epithelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] +synonym: "activation of mammary gland epithelial cell proliferation" NARROW [] +synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW [] +synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT [] +is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation + +[Term] +id: GO:0033602 +name: negative regulation of dopamine secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] +synonym: "down regulation of dopamine secretion" EXACT [] +synonym: "down-regulation of dopamine secretion" EXACT [] +synonym: "downregulation of dopamine secretion" EXACT [] +synonym: "inhibition of dopamine secretion" NARROW [] +is_a: GO:0014059 ! regulation of dopamine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion +relationship: negatively_regulates GO:0014046 ! dopamine secretion + +[Term] +id: GO:0033603 +name: positive regulation of dopamine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] +synonym: "activation of dopamine secretion" NARROW [] +synonym: "stimulation of dopamine secretion" NARROW [] +synonym: "up regulation of dopamine secretion" EXACT [] +synonym: "up-regulation of dopamine secretion" EXACT [] +synonym: "upregulation of dopamine secretion" EXACT [] +is_a: GO:0014059 ! regulation of dopamine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion +relationship: positively_regulates GO:0014046 ! dopamine secretion + +[Term] +id: GO:0033604 +name: negative regulation of catecholamine secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] +synonym: "down regulation of catecholamine secretion" EXACT [] +synonym: "down-regulation of catecholamine secretion" EXACT [] +synonym: "downregulation of catecholamine secretion" EXACT [] +synonym: "inhibition of catecholamine secretion" NARROW [] +is_a: GO:0050433 ! regulation of catecholamine secretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0033605 +name: positive regulation of catecholamine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] +synonym: "activation of catecholamine secretion" NARROW [] +synonym: "stimulation of catecholamine secretion" NARROW [] +synonym: "up regulation of catecholamine secretion" EXACT [] +synonym: "up-regulation of catecholamine secretion" EXACT [] +synonym: "upregulation of catecholamine secretion" EXACT [] +is_a: GO:0050433 ! regulation of catecholamine secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0033606 +name: chemokine receptor transport within lipid bilayer +namespace: biological_process +def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah] +synonym: "chemokine receptor translocation within membrane" EXACT [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0033607 +name: SOD1-Bcl-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0033608 +name: formyl-CoA transferase activity +namespace: molecular_function +def: "Catalysis of the reaction formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, GOC:mlg] +synonym: "formyl-CoA oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] +synonym: "formyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.16] +synonym: "formyl-coenzyme A transferase activity" EXACT [EC:2.8.3.16] +xref: EC:2.8.3.16 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0033609 +name: oxalate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [ChEBI:30623, GOC:mlg] +synonym: "ethanedioate metabolic process" EXACT [] +synonym: "ethanedioic acid metabolic process" EXACT [] +synonym: "oxalate metabolism" EXACT [] +synonym: "oxalic acid metabolic process" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0033610 +name: oxalate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [ChEBI:30623, GOC:mlg] +synonym: "ethanedioate biosynthetic process" EXACT [] +synonym: "ethanedioic acid biosynthetic process" EXACT [] +synonym: "oxalate anabolism" EXACT [] +synonym: "oxalate biosynthesis" EXACT [] +synonym: "oxalate formation" EXACT [] +synonym: "oxalate synthesis" EXACT [] +synonym: "oxalic acid biosynthetic process" EXACT [] +is_a: GO:0033609 ! oxalate metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0033611 +name: oxalate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [ChEBI:30623, GOC:mlg] +synonym: "ethanedioate catabolic process" EXACT [] +synonym: "ethanedioic acid catabolic process" EXACT [] +synonym: "oxalate breakdown" EXACT [] +synonym: "oxalate catabolism" EXACT [] +synonym: "oxalate degradation" EXACT [] +synonym: "oxalic acid catabolic process" EXACT [] +is_a: GO:0033609 ! oxalate metabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0033612 +name: receptor serine/threonine kinase binding +namespace: molecular_function +def: "Interacting selectively with a receptor that possesses protein serine/threonine kinase activity." [GOC:mah] +synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0033613 +name: transcription activator binding +namespace: molecular_function +def: "Interacting selectively with a transcription activator, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0033614 +name: chloroplast proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah] +is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly +relationship: part_of GO:0009658 ! chloroplast organization + +[Term] +id: GO:0033615 +name: mitochondrial proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah] +is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0033616 +name: plasma membrane proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah] +is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0033617 +name: mitochondrial respiratory chain complex IV assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah] +subset: gosubset_prok +synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD [] +synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT [] +is_a: GO:0008535 ! respiratory chain complex IV assembly +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly + +[Term] +id: GO:0033618 +name: plasma membrane respiratory chain complex IV assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah] +subset: gosubset_prok +synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD [] +synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT [] +is_a: GO:0008535 ! respiratory chain complex IV assembly +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0033619 +name: membrane protein proteolysis +namespace: biological_process +def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pd] +subset: gosubset_prok +is_a: GO:0006508 ! proteolysis + +[Term] +id: GO:0033620 +name: Mei2 nuclear dot +namespace: cellular_component +def: "A nuclear body that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [PMID:12808043] +synonym: "Mei2 dot" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0033621 +name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +namespace: biological_process +def: "The selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445] +comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing. +synonym: "degradation of meiosis-specific transcripts" EXACT [] +synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT [] +synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT [] +synonym: "mRNA degradation, meiosis-specific transcripts" EXACT [] +synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0033622 +name: integrin activation +namespace: biological_process +def: "The chemical reactions and pathways involving an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "integrin complex activation" EXACT [] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0033623 +name: regulation of integrin activation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add] +synonym: "regulation of integrin complex activation" EXACT [] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0033622 ! integrin activation + +[Term] +id: GO:0033624 +name: negative regulation of integrin activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of integrin activation." [GOC:add] +synonym: "negative regulation of integrin complex activation" EXACT [] +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0033623 ! regulation of integrin activation +relationship: negatively_regulates GO:0033622 ! integrin activation + +[Term] +id: GO:0033625 +name: positive regulation of integrin activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add] +synonym: "positive regulation of integrin complex activation" EXACT [] +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0033623 ! regulation of integrin activation +relationship: positively_regulates GO:0033622 ! integrin activation + +[Term] +id: GO:0033626 +name: cell surface receptor linked signal transduction leading to integrin activation +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT [] +is_a: GO:0007166 ! cell surface receptor linked signal transduction + +[Term] +id: GO:0033627 +name: cell adhesion mediated by integrin +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0007155 ! cell adhesion + +[Term] +id: GO:0033628 +name: regulation of cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] +synonym: "regulation of cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033629 +name: negative regulation of cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] +synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin +relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033630 +name: positive regulation of cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] +synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin +is_a: GO:0045785 ! positive regulation of cell adhesion +relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033631 +name: cell-cell adhesion mediated by integrin +namespace: biological_process +def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "cell-cell adhesion mediated by integrin complex " EXACT [] +is_a: GO:0016337 ! cell-cell adhesion +is_a: GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033632 +name: regulation of cell-cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] +synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin +relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin + +[Term] +id: GO:0033633 +name: negative regulation of cell-cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] +synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin +is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin +relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin + +[Term] +id: GO:0033634 +name: positive regulation of cell-cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] +synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin +is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin +relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin + +[Term] +id: GO:0033635 +name: modulation by symbiont of host response to abiotic stimulus +namespace: biological_process +def: "Any process by which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology + +[Term] +id: GO:0033636 +name: modulation by symbiont of host response to temperature stimulus +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "modulation by symbiont of host response to thermal stimulus" EXACT [] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus + +[Term] +id: GO:0033637 +name: modulation by symbiont of host response to cold +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "freezing tolerance" RELATED [] +is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus + +[Term] +id: GO:0033638 +name: modulation by symbiont of host response to heat +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response to heat shock" RELATED [] +is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus + +[Term] +id: GO:0033639 +name: modulation by symbiont of host response to water +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus + +[Term] +id: GO:0033640 +name: modulation by symbiont of host response to osmotic stress +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus + +[Term] +id: GO:0033641 +name: modulation by symbiont of host response to pH +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus + +[Term] +id: GO:0033642 +name: modulation by symbiont of host response to gravitational stimulus +namespace: biological_process +def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response to gravitational stimulus" BROAD [] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus + +[Term] +id: GO:0033643 +name: host cell part +namespace: cellular_component +def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0043657 ! host cell + +[Term] +id: GO:0033644 +name: host cell membrane +namespace: cellular_component +def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0033645 +name: host cell endomembrane system +namespace: cellular_component +def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0033646 +name: host intracellular part +namespace: cellular_component +def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +is_a: GO:0043656 ! intracellular region of host + +[Term] +id: GO:0033647 +name: host intracellular organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +is_a: GO:0033646 ! host intracellular part + +[Term] +id: GO:0033648 +name: host intracellular membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +synonym: "host intracellular membrane-enclosed organelle" EXACT [] +is_a: GO:0033647 ! host intracellular organelle + +[Term] +id: GO:0033650 +name: host cell mitochondrion +namespace: cellular_component +def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "host mitochondria" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0033651 +name: host cell plastid +namespace: cellular_component +def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0033652 +name: host cell chloroplast +namespace: cellular_component +def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033651 ! host cell plastid + +[Term] +id: GO:0033653 +name: host cell chloroplast part +namespace: cellular_component +def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "host chloroplast component" EXACT [] +is_a: GO:0033652 ! host cell chloroplast + +[Term] +id: GO:0033654 +name: host cell chloroplast thylakoid membrane +namespace: cellular_component +def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033653 ! host cell chloroplast part + +[Term] +id: GO:0033655 +name: host cell cytoplasm part +namespace: cellular_component +def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +synonym: "cytoplasm component" BROAD [] +is_a: GO:0033646 ! host intracellular part +relationship: part_of GO:0030430 ! host cell cytoplasm + +[Term] +id: GO:0033656 +name: modification by symbiont of host chloroplast +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0033657 +name: modification by symbiont of host chloroplast part +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033656 ! modification by symbiont of host chloroplast + +[Term] +id: GO:0033658 +name: modification by symbiont of host chloroplast thylakoid +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033657 ! modification by symbiont of host chloroplast part + +[Term] +id: GO:0033659 +name: modification by symbiont of host mitochondrion +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0033660 +name: negative regulation by symbiont of host resistance gene-dependent defense response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT [] +synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT [] +synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW [] +synonym: "suppression by symbiont of host resistance gene-dependent defense response" EXACT [] +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response + +[Term] +id: GO:0033661 +name: negative regulation by symbiont of defense-related host reactive oxygen species production +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "down regulation by organism of defense-related host metabolic burst" EXACT [] +synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT [] +synonym: "downregulation by organism of defense-related host AOS production" EXACT [] +synonym: "inhibition by organism of defense-related host active oxygen species production" NARROW [] +synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT [] +synonym: "negative regulation by organism of defense-related host ROI production" EXACT [] +synonym: "negative regulation by organism of defense-related host ROS production" EXACT [] +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production + +[Term] +id: GO:0033662 +name: modulation by symbiont of host defense-related protein level +namespace: biological_process +def: "The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0075344 ! modulation by symbiont of host protein levels + +[Term] +id: GO:0033663 +name: negative regulation by symbiont of host defense-related protein level +namespace: biological_process +def: "Any process by which the symbiont stops or reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level +is_a: GO:0052037 ! negative regulation by symbiont of host defense response + +[Term] +id: GO:0033664 +name: positive regulation by symbiont of host defense-related protein level +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0033665 +name: regulation of growth or development of symbiont within host +namespace: biological_process +def: "Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb] +synonym: "modulation of growth or development of organism within host" EXACT [] +synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb] +synonym: "modulation of invasive growth" BROAD [] +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: regulates GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0033666 +name: positive regulation of growth or development of symbiont within host +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] +synonym: "positive regulation of invasive growth" BROAD [] +synonym: "up regulation of growth or development of organism within host" EXACT [] +synonym: "up-regulation of growth or development of organism within host" EXACT [] +synonym: "upregulation of growth or development of organism within host" EXACT [] +is_a: GO:0033665 ! regulation of growth or development of symbiont within host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0033667 +name: negative regulation of growth or development of symbiont within host +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] +synonym: "down regulation of growth or development of organism within host" EXACT [] +synonym: "down-regulation of growth or development of organism within host" EXACT [] +synonym: "downregulation of growth or development of organism within host" EXACT [] +synonym: "inhibition of growth of development of organism within host" NARROW [] +synonym: "negative regulation of invasive growth" BROAD [] +is_a: GO:0033665 ! regulation of growth or development of symbiont within host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0033668 +name: negative regulation by symbiont of host apoptosis +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'. +synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptosis +is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death +is_a: GO:0052150 ! modulation by symbiont of host apoptosis + +[Term] +id: GO:0033670 +name: regulation of NAD+ kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] +synonym: "NAD kinase regulator" NARROW [] +synonym: "regulation of NAD kinase activity" EXACT [] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0033671 +name: negative regulation of NAD+ kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] +synonym: "down regulation of NAD+ kinase activity" EXACT [] +synonym: "down-regulation of NAD+ kinase activity" EXACT [] +synonym: "downregulation of NAD+ kinase activity" EXACT [] +synonym: "inhibition of NAD+ kinase activity" NARROW [] +synonym: "NAD+ kinase inhibitor" NARROW [] +is_a: GO:0033670 ! regulation of NAD+ kinase activity +is_a: GO:0033673 ! negative regulation of kinase activity + +[Term] +id: GO:0033672 +name: positive regulation of NAD+ kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] +synonym: "NAD+ kinase activator" NARROW [] +synonym: "stimulation of NAD+ kinase activity" NARROW [] +synonym: "up regulation of NAD+ kinase activity" EXACT [] +synonym: "up-regulation of NAD+ kinase activity" EXACT [] +synonym: "upregulation of NAD+ kinase activity" EXACT [] +is_a: GO:0033670 ! regulation of NAD+ kinase activity +is_a: GO:0033674 ! positive regulation of kinase activity + +[Term] +id: GO:0033673 +name: negative regulation of kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] +synonym: "down regulation of kinase activity" EXACT [] +synonym: "down-regulation of kinase activity" EXACT [] +synonym: "downregulation of kinase activity" EXACT [] +synonym: "inhibition of kinase activity" NARROW [] +synonym: "kinase inhibitor" NARROW [] +is_a: GO:0043549 ! regulation of kinase activity +is_a: GO:0051348 ! negative regulation of transferase activity + +[Term] +id: GO:0033674 +name: positive regulation of kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] +synonym: "kinase activator" NARROW [] +synonym: "stimulation of kinase activity" NARROW [] +synonym: "up regulation of kinase activity" EXACT [] +synonym: "up-regulation of kinase activity" EXACT [] +synonym: "upregulation of kinase activity" EXACT [] +is_a: GO:0043549 ! regulation of kinase activity +is_a: GO:0051347 ! positive regulation of transferase activity + +[Term] +id: GO:0033675 +name: pericanalicular vesicle +namespace: cellular_component +def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0033676 +name: double-stranded DNA-dependent ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of double-stranded DNA; drives another reaction." [GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "dsDNA-dependent ATPase activity" EXACT [] +is_a: GO:0008094 ! DNA-dependent ATPase activity + +[Term] +id: GO:0033677 +name: DNA/RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah] +comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'. +subset: gosubset_prok +xref: EC:2.7.7.- +xref: Reactome:7008 +is_a: GO:0004386 ! helicase activity + +[Term] +id: GO:0033678 +name: 5'-3' DNA/RNA helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] +synonym: "5' to 3' DNA/RNA helicase activity" EXACT [] +is_a: GO:0033677 ! DNA/RNA helicase activity + +[Term] +id: GO:0033679 +name: 3'-5' DNA/RNA helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] +synonym: "3' to 5' DNA/RNA helicase activity" EXACT [] +is_a: GO:0033677 ! DNA/RNA helicase activity + +[Term] +id: GO:0033680 +name: ATP-dependent DNA/RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex." [GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0008026 ! ATP-dependent helicase activity +is_a: GO:0008094 ! DNA-dependent ATPase activity +is_a: GO:0033677 ! DNA/RNA helicase activity + +[Term] +id: GO:0033681 +name: ATP-dependent 3'-5' DNA/RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah] +synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT [] +is_a: GO:0033679 ! 3'-5' DNA/RNA helicase activity +is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity + +[Term] +id: GO:0033682 +name: ATP-dependent 5'-3' DNA/RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah] +synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT [] +is_a: GO:0033678 ! 5'-3' DNA/RNA helicase activity +is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity + +[Term] +id: GO:0033683 +name: nucleotide-excision repair, DNA incision +namespace: biological_process +def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896] +subset: gosubset_prok +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0033684 +name: regulation of luteinizing hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] +is_a: GO:0032276 ! regulation of gonadotropin secretion +relationship: regulates GO:0032275 ! luteinizing hormone secretion + +[Term] +id: GO:0033685 +name: negative regulation of luteinizing hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] +synonym: "down regulation of luteinizing hormone secretion" EXACT [] +synonym: "down-regulation of luteinizing hormone secretion" EXACT [] +synonym: "downregulation of luteinizing hormone secretion" EXACT [] +synonym: "inhibition of luteinizing hormone secretion" NARROW [] +is_a: GO:0032277 ! negative regulation of gonadotropin secretion +is_a: GO:0033684 ! regulation of luteinizing hormone secretion +relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion + +[Term] +id: GO:0033686 +name: positive regulation of luteinizing hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] +synonym: "activation of luteinizing hormone secretion" NARROW [] +synonym: "stimulation of luteinizing hormone secretion" NARROW [] +synonym: "up regulation of luteinizing hormone secretion" EXACT [] +synonym: "up-regulation of luteinizing hormone secretion" EXACT [] +synonym: "upregulation of luteinizing hormone secretion" EXACT [] +is_a: GO:0032278 ! positive regulation of gonadotropin secretion +is_a: GO:0033684 ! regulation of luteinizing hormone secretion +relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion + +[Term] +id: GO:0033687 +name: osteoblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0033688 +name: regulation of osteoblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0033687 ! osteoblast proliferation + +[Term] +id: GO:0033689 +name: negative regulation of osteoblast proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah] +synonym: "down regulation of osteoblast proliferation" EXACT [] +synonym: "down-regulation of osteoblast proliferation" EXACT [] +synonym: "downregulation of osteoblast proliferation" EXACT [] +synonym: "inhibition of osteoblast proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0033688 ! regulation of osteoblast proliferation +relationship: negatively_regulates GO:0033687 ! osteoblast proliferation + +[Term] +id: GO:0033690 +name: positive regulation of osteoblast proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah] +synonym: "activation of osteoblast proliferation" NARROW [] +synonym: "stimulation of osteoblast proliferation" NARROW [] +synonym: "up regulation of osteoblast proliferation" EXACT [] +synonym: "up-regulation of osteoblast proliferation" EXACT [] +synonym: "upregulation of osteoblast proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0033688 ! regulation of osteoblast proliferation +relationship: positively_regulates GO:0033687 ! osteoblast proliferation + +[Term] +id: GO:0033691 +name: sialic acid binding +namespace: molecular_function +def: "Interacting selectively with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [ChEBI:26667, GOC:add, http://www.biology-online.org, ISBN:0721601465] +synonym: "N-acetylneuraminic acid binding" NARROW [] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0033692 +name: cellular polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, occurring at the level of an individual cell." [GOC:go_curators] +subset: gosubset_prok +synonym: "cellular glycan biosynthesis" EXACT [] +synonym: "cellular glycan biosynthetic process" EXACT [] +synonym: "cellular polysaccharide anabolism" EXACT [] +synonym: "cellular polysaccharide biosynthesis" EXACT [] +synonym: "cellular polysaccharide formation" EXACT [] +synonym: "cellular polysaccharide synthesis" EXACT [] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0034961 ! cellular biopolymer biosynthetic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0033693 +name: neurofilament bundle assembly +namespace: biological_process +def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295] +synonym: "NF bundle assembly" EXACT [] +is_a: GO:0045110 ! intermediate filament bundle assembly +is_a: GO:0060052 ! neurofilament cytoskeleton organization + +[Term] +id: GO:0033694 +name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +subset: gosubset_prok +xref: EC:1.5.7 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0033695 +name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5, GOC:mah] +subset: gosubset_prok +xref: EC:1.17.5 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0033696 +name: negative regulation of extent of heterochromatin formation +namespace: biological_process +def: "Any process that reduces the extent of heterochromatin formation; reduces the size of a chromosomal region converted to heterochromatin." [GOC:mah] +synonym: "maintenance of heterochromatin boundaries" RELATED [] +synonym: "negative regulation of heterochromatin spreading" RELATED [] +is_a: GO:0031452 ! negative regulation of heterochromatin formation +is_a: GO:0031454 ! regulation of extent of heterochromatin formation + +[Term] +id: GO:0033697 +name: positive regulation of extent of heterochromatin formation +namespace: biological_process +def: "Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah] +synonym: "positive regulation of heterochromatin spreading" RELATED [] +is_a: GO:0031453 ! positive regulation of heterochromatin formation +is_a: GO:0031454 ! regulation of extent of heterochromatin formation + +[Term] +id: GO:0033698 +name: Clr6 histone deacetylase complex I/I' +namespace: cellular_component +def: "A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe)." [GOC:vw, PMID:17450151] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0033699 +name: DNA 5'-adenosine monophosphate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982] +synonym: "AMP-removal activity" RELATED [] +synonym: "DNA 5'-adenylate hydrolase activity" EXACT [] +synonym: "DNA adenylate hydrolysis activity" BROAD [] +synonym: "DNA de-adenylation" RELATED [] +synonym: "DNA deadenylation" RELATED [] +is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity + +[Term] +id: GO:0033700 +name: phospholipid efflux +namespace: biological_process +def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah] +synonym: "phospholipid export" EXACT [] +is_a: GO:0015914 ! phospholipid transport + +[Term] +id: GO:0033701 +name: dTDP-galactose 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186] +synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.186] +synonym: "dTDPgalactose 6-dehydrogenase activity" EXACT [EC:1.1.1.186] +synonym: "thymidine-diphosphate-galactose dehydrogenase activity" EXACT [EC:1.1.1.186] +xref: EC:1.1.1.186 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033702 +name: (+)-trans-carveol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-trans-carveol + NAD+ = (+)-(S)-carvone + NADH + H+." [EC:1.1.1.275] +synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.275] +xref: EC:1.1.1.275 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033703 +name: 3beta-hydroxy-5beta-steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+." [EC:1.1.1.277] +synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.277] +synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" EXACT [EC:1.1.1.277] +synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" EXACT [EC:1.1.1.277] +xref: EC:1.1.1.277 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033704 +name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnan-3,20-dione + NADPH + H+." [EC:1.1.1.278] +synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.278] +xref: EC:1.1.1.278 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033705 +name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281] +comment: Note that this enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). +synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281] +synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" EXACT [EC:1.1.1.281] +synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" EXACT [EC:1.1.1.281] +synonym: "Rmd" RELATED [EC:1.1.1.281] +xref: EC:1.1.1.281 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033706 +name: quinate/shikimate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+ and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282] +synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.1.1.282] +synonym: "YdiB" RELATED [EC:1.1.1.282] +xref: EC:1.1.1.282 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033707 +name: 3''-deamino-3''-oxonicotianamine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285] +synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" EXACT [EC:1.1.1.285] +xref: EC:1.1.1.285 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033708 +name: isocitrate-homoisocitrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286] +synonym: "homoisocitrate-isocitrate dehydrogenase activity" EXACT [EC:1.1.1.286] +synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.286] +synonym: "PH1722" RELATED [EC:1.1.1.286] +xref: EC:1.1.1.286 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033709 +name: D-arabinitol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reactions: D-arabinitol + NADP+ = D-xylulose + NADPH + H+ and D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287] +synonym: "ARD1p" RELATED [EC:1.1.1.287] +synonym: "D-arabinitol dehydrogenase 1 activity" NARROW [EC:1.1.1.287] +synonym: "D-arabinitol:NADP+ dehydrogenase activity" EXACT [EC:1.1.1.287] +synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" EXACT [EC:1.1.1.287] +xref: EC:1.1.1.287 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033711 +name: 4-phosphoerythronate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH + H+." [EC:1.1.1.290] +synonym: "4-O-phosphoerythronate dehydrogenase activity" EXACT [EC:1.1.1.290] +synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.290] +synonym: "4PE dehydrogenase activity" EXACT [EC:1.1.1.290] +synonym: "erythronate-4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.290] +synonym: "PdxB" RELATED [EC:1.1.1.290] +synonym: "PdxB 4PE dehydrogenase activity" EXACT [EC:1.1.1.290] +xref: EC:1.1.1.290 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033712 +name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+." [EC:1.1.1.292] +synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.292] +synonym: "AFR" RELATED [EC:1.1.1.292] +xref: EC:1.1.1.292 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033713 +name: choline:oxygen 1-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + H2O2." [EC:1.1.3.17] +synonym: "choline oxidase activity" BROAD [EC:1.1.3.17] +xref: EC:1.1.3.17 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033714 +name: secondary-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a secondary alcohol + O2 = a ketone + H2O2." [EC:1.1.3.18] +synonym: "polyvinyl alcohol oxidase activity" EXACT [EC:1.1.3.18] +synonym: "secondary alcohol oxidase activity" EXACT [EC:1.1.3.18] +synonym: "secondary-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.18] +xref: EC:1.1.3.18 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033715 +name: nucleoside oxidase activity +namespace: molecular_function +def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O and (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28] +synonym: "nucleoside:oxygen 5'-oxidoreductase activity" EXACT [EC:1.1.3.28] +xref: EC:1.1.3.28 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033716 +name: nucleoside oxidase (H2O2-forming) activity +namespace: molecular_function +def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 H2O2, (1a) adenosine + O2 = 5'-dehydroadenosine + H2O2 and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + H2O2." [EC:1.1.3.39] +synonym: "nucleoside:oxygen 5'-oxidoreductase (H2O2-forming) activity" EXACT [EC:1.1.3.39] +xref: EC:1.1.3.39 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033717 +name: gluconate 2-dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3] +synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3] +synonym: "D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.3] +synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" EXACT [EC:1.1.99.3] +synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.3] +synonym: "D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.3] +synonym: "gluconate oxidase activity" EXACT [EC:1.1.99.3] +synonym: "gluconic acid dehydrogenase activity" EXACT [EC:1.1.99.3] +synonym: "gluconic dehydrogenase activity" EXACT [EC:1.1.99.3] +xref: EC:1.1.99.3 +is_a: GO:0008875 ! gluconate dehydrogenase activity + +[Term] +id: GO:0033718 +name: pyranose dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29] +synonym: "PDH" RELATED [EC:1.1.99.29] +synonym: "pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] +synonym: "pyranose-quinone oxidoreductase activity" EXACT [EC:1.1.99.29] +synonym: "pyranose:acceptor oxidoreductase activity" EXACT [EC:1.1.99.29] +synonym: "quinone-dependent pyranose dehydrogenase activity" EXACT [EC:1.1.99.29] +xref: EC:1.1.99.29 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033719 +name: 2-oxo-acid reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30] +synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.30] +synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" EXACT [EC:1.1.99.30] +synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30] +synonym: "HVOR" RELATED [EC:1.1.99.30] +xref: EC:1.1.99.30 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033720 +name: (S)-mandelate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31] +synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.31] +synonym: "L(+)-mandelate dehydrogenase activity" EXACT [EC:1.1.99.31] +synonym: "MDH" RELATED [EC:1.1.99.31] +xref: EC:1.1.99.31 +xref: UM-BBD_enzymeID:e0651 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033721 +name: aldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4] +synonym: "aldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.4] +synonym: "NADP-acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] +synonym: "NADP-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.4] +xref: EC:1.2.1.4 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033722 +name: malonate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15] +synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.15] +synonym: "malonic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.15] +xref: EC:1.2.1.15 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033723 +name: fluoroacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69] +synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.69] +xref: EC:1.2.1.69 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033726 +name: aldehyde ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5] +synonym: "aldehyde:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] +synonym: "AOR" RELATED [EC:1.2.7.5] +synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5] +xref: EC:1.2.7.5 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0033727 +name: aldehyde dehydrogenase (FAD-independent) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7] +synonym: "aldehyde oxidoreductase activity" EXACT [EC:1.2.99.7] +synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" EXACT [EC:1.2.99.7] +synonym: "AORDd" RELATED [EC:1.2.99.7] +synonym: "Mop" RELATED [EC:1.2.99.7] +xref: EC:1.2.99.7 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0033728 +name: divinyl chlorophyllide a 8-vinyl-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75] +synonym: "4VCR" RELATED [EC:1.3.1.75] +synonym: "[4-vinyl]chlorophyllide a reductase activity" EXACT [EC:1.3.1.75] +synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.75] +xref: EC:1.3.1.75 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033729 +name: anthocyanidin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77] +synonym: "ANR" RELATED [EC:1.3.1.77] +synonym: "AtANR" RELATED [EC:1.3.1.77] +synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.77] +synonym: "MtANR" RELATED [EC:1.3.1.77] +xref: EC:1.3.1.77 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033730 +name: arogenate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78] +synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78] +synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.78] +synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78] +synonym: "TyrAa" RELATED [EC:1.3.1.78] +synonym: "TyrAAT1" RELATED [EC:1.3.1.78] +synonym: "TyrAAT2" RELATED [EC:1.3.1.78] +xref: EC:1.3.1.78 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033731 +name: arogenate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79] +synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79] +synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.79] +synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79] +xref: EC:1.3.1.79 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033732 +name: pyrroloquinoline-quinone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O." [EC:1.3.3.11] +synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.3.3.11] +synonym: "PqqC" RELATED [EC:1.3.3.11] +xref: EC:1.3.3.11 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0033734 +name: (R)-benzylsuccinyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.99.21] +synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.21] +synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.21] +synonym: "BbsG" RELATED [EC:1.3.99.21] +xref: EC:1.3.99.21 +xref: UM-BBD_enzymeID:e0650 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0033735 +name: aspartate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21] +synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.21] +synonym: "NAD-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] +synonym: "NADH2-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] +synonym: "NADP+-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21] +xref: EC:1.4.1.21 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0033736 +name: L-lysine 6-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + O2 + H2O = 2-aminoadipate 6-semialdehyde + H2O2 + NH3." [EC:1.4.3.20] +synonym: "L-lysine-epsilon-oxidase activity" EXACT [EC:1.4.3.20] +synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" EXACT [EC:1.4.3.20] +synonym: "Lod" RELATED [EC:1.4.3.20] +synonym: "LodA" RELATED [EC:1.4.3.20] +synonym: "marinocine" RELATED [EC:1.4.3.20] +xref: EC:1.4.3.20 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0033737 +name: 1-pyrroline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.5.1.35] +synonym: "1-pyrroline:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.35] +synonym: "ABALDH" RELATED [EC:1.5.1.35] +synonym: "gamma-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.5.1.35] +synonym: "YdcW" RELATED [EC:1.5.1.35] +xref: EC:1.5.1.35 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033738 +name: methylenetetrahydrofolate reductase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1] +synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1] +synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1] +xref: EC:1.5.7.1 +is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0033739 +name: queuine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+." [EC:1.7.1.13] +synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.13] +synonym: "7-cyano-7-deazaguanine reductase activity" EXACT [EC:1.7.1.13] +synonym: "preQ0 oxidoreductase activity" EXACT [EC:1.7.1.13] +synonym: "preQ0 reductase activity" EXACT [EC:1.7.1.13] +synonym: "QueF" RELATED [EC:1.7.1.13] +synonym: "queuine:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.13] +synonym: "YkvM" RELATED [EC:1.7.1.13] +xref: EC:1.7.1.13 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0033740 +name: hydroxylamine oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.99.8] +synonym: "hydroxylamine:acceptor oxidoreductase activity" EXACT [EC:1.7.99.8] +xref: EC:1.7.99.8 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033741 +name: adenylyl-sulfate reductase (glutathione) activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione." [EC:1.8.4.9] +synonym: "5'-adenylylsulfate reductase activity" EXACT [EC:1.8.4.9] +synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] +synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9] +synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9] +xref: EC:1.8.4.9 +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0033743 +name: peptide-methionine (R)-S-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.12] +synonym: "methionine S-oxide reductase (R-form oxidizing) activity" EXACT [EC:1.8.4.12] +synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12] +synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12] +synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12] +synonym: "MsrB" RELATED [EC:1.8.4.12] +synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.12] +synonym: "PilB" RELATED [EC:1.8.4.12] +synonym: "pMRsr" RELATED [EC:1.8.4.12] +synonym: "pMSR" RELATED [EC:1.8.4.12] +synonym: "selenoprotein R" RELATED [EC:1.8.4.12] +synonym: "SelR" RELATED [EC:1.8.4.12] +synonym: "SelX" RELATED [EC:1.8.4.12] +xref: EC:1.8.4.12 +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0033744 +name: L-methionine-(S)-S-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13] +synonym: "acetylmethionine sulfoxide reductase activity" EXACT [EC:1.8.4.13] +synonym: "free-methionine (S)-S-oxide reductase activity" EXACT [EC:1.8.4.13] +synonym: "fSMsr" RELATED [EC:1.8.4.13] +synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" EXACT [EC:1.8.4.13] +synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.13] +synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13] +synonym: "methyl sulfoxide reductase I and II activity" EXACT [EC:1.8.4.13] +xref: EC:1.8.4.13 +is_a: GO:0000317 ! methionine-S-oxide reductase activity + +[Term] +id: GO:0033745 +name: L-methionine-(R)-S-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14] +synonym: "free met-R-(o) reductase activity" EXACT [EC:1.8.4.14] +synonym: "free-methionine (R)-S-oxide reductase activity" EXACT [EC:1.8.4.14] +synonym: "fRMsr" RELATED [EC:1.8.4.14] +synonym: "FRMsr" RELATED [EC:1.8.4.14] +synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.14] +xref: EC:1.8.4.14 +is_a: GO:0000317 ! methionine-S-oxide reductase activity + +[Term] +id: GO:0033746 +name: histone demethylase activity (H3-R2 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein." [GOC:mah] +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0033747 +name: versatile peroxidase activity +namespace: molecular_function +def: "Catalysis of the reactions: Reactive Black 5 + H2O2 = oxidized Reactive Black 5 + 2 H2O and donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.16] +synonym: "hybrid peroxidase activity" EXACT [EC:1.11.1.16] +synonym: "polyvalent peroxidase activity" EXACT [EC:1.11.1.16] +synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.16] +synonym: "VP" RELATED [EC:1.11.1.16] +xref: EC:1.11.1.16 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0033748 +name: hydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6] +synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6] +synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6] +synonym: "hydrogen:(acceptor) oxidoreductase activity" EXACT [EC:1.12.99.6] +synonym: "hydrogen:acceptor oxidoreductase activity" EXACT [EC:1.12.99.6] +synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6] +synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6] +xref: EC:1.12.99.6 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0033749 +name: histone demethylase activity (H4-R3 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein." [GOC:mah] +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0033750 +name: ribosome localization +namespace: biological_process +def: "A process by which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] +synonym: "ribosome localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0033751 +name: linoleate diol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [EC:1.13.11.44] +synonym: "linoleate (8R)-dioxygenase activity" EXACT [EC:1.13.11.44] +synonym: "linoleate 8-dioxygenase activity" EXACT [EC:1.13.11.44] +synonym: "linoleate:oxygen 7S,8S-oxidoreductase activity" EXACT [EC:1.13.11.44] +xref: EC:1.13.11.44 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033752 +name: acetylacetone-cleaving enzyme activity +namespace: molecular_function +def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50] +synonym: "acetylacetone dioxygenase activity" EXACT [EC:1.13.11.50] +synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50] +synonym: "acetylacetone:oxygen oxidoreductase activity" EXACT [EC:1.13.11.50] +synonym: "diketone cleaving dioxygenase activity" EXACT [EC:1.13.11.50] +synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50] +synonym: "Dke1" RELATED [EC:1.13.11.50] +xref: EC:1.13.11.50 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033753 +name: establishment of ribosome localization +namespace: biological_process +def: "The directed movement of the ribosome to a specific location." [GOC:mah] +synonym: "establishment of ribosome localization" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0033750 ! ribosome localization + +[Term] +id: GO:0033754 +name: indoleamine 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.52] +synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52] +synonym: "IDO" RELATED [EC:1.13.11.52] +synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52] +xref: EC:1.13.11.52 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033755 +name: sulfur oxygenase/reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55] +synonym: "SOR" RELATED [EC:1.13.11.55] +synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55] +synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" EXACT [EC:1.13.11.55] +synonym: "sulphur oxygenase/reductase activity" EXACT [] +xref: EC:1.13.11.55 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033756 +name: Oplophorus-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13] +synonym: "Oplophorus luciferase activity" EXACT [EC:1.13.12.13] +synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" EXACT [EC:1.13.12.13] +xref: EC:1.13.12.13 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0033757 +name: glucoside 3-dehydrogenase +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13] +synonym: "D-aldohexopyranoside dehydrogenase" EXACT [EC:1.1.99.13] +synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" EXACT [EC:1.1.99.13] +synonym: "D-aldohexoside:acceptor 3-oxidoreductase" EXACT [EC:1.1.99.13] +synonym: "D-aldohexoside:cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] +synonym: "hexopyranoside-cytochrome c oxidoreductase" EXACT [EC:1.1.99.13] +xref: EC:1.1.99.13 +xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033758 +name: clavaminate synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O and proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21] +synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21] +synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21] +synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21] +xref: EC:1.14.11.21 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0033759 +name: flavone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.11.22] +synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" EXACT [EC:1.14.11.22] +synonym: "flavone synthase I activity" EXACT [EC:1.14.11.22] +synonym: "FNS I" RELATED [EC:1.14.11.22] +xref: EC:1.14.11.22 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0033760 +name: 2'-deoxymugineic-acid 2'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = mugineic acid + succinate + CO2." [EC:1.14.11.24] +synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" EXACT [EC:1.14.11.24] +synonym: "IDS3" RELATED [EC:1.14.11.24] +xref: EC:1.14.11.24 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0033761 +name: mugineic-acid 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2 and 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25] +synonym: "IDS2" RELATED [EC:1.14.11.25] +synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25] +xref: EC:1.14.11.25 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0033762 +name: response to glucagon stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl] +is_a: GO:0043434 ! response to peptide hormone stimulus + +[Term] +id: GO:0033763 +name: proline 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28] +synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.28] +synonym: "P-3-H" RELATED [EC:1.14.11.28] +xref: EC:1.14.11.28 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0033764 +name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah] +subset: gosubset_prok +xref: EC:1.1.1.- +is_a: GO:0016229 ! steroid dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033765 +name: steroid dehydrogenase activity, acting on the CH-CH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah] +subset: gosubset_prok +xref: EC:1.1.1.- +is_a: GO:0016229 ! steroid dehydrogenase activity +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0033766 +name: 2-hydroxyquinoline 8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = quinolin-2,8-diol + NAD+ + H2O." [EC:1.14.13.61] +synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" EXACT [EC:1.14.13.61] +synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" EXACT [EC:1.14.13.61] +xref: EC:1.14.13.61 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033767 +name: 4-hydroxyacetophenone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4-hydroxyphenyl)ethan-1-one + NADPH + H+ + O2 = 4-hydroxyphenyl acetate + NADP+ + H2O." [EC:1.14.13.80, EC:1.14.13.84] +synonym: "(+)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80] +synonym: "(+)-limonene-6-hydroxylase activity" EXACT [EC:1.14.13.80] +synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT [EC:1.14.13.84] +synonym: "(R)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80] +synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.80] +synonym: "HAPMO" RELATED [EC:1.14.13.84] +xref: EC:1.14.13.80 +xref: EC:1.14.13.84 +xref: UM-BBD_enzymeID:e0479 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033768 +name: SUMO-targeted ubiquitin ligase complex +namespace: cellular_component +def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex + +[Term] +id: GO:0033769 +name: glyceollin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85] +synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.14.13.85] +synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.13.85] +xref: EC:1.14.13.85 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033770 +name: 2-hydroxyisoflavanone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86] +synonym: "2-HIS" RELATED [EC:1.14.13.86] +synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" EXACT [EC:1.14.13.86] +xref: EC:1.14.13.86 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033771 +name: licodione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: liquiritigenin + NADPH + H+ + O2 = licodione + NADP+ + H2O." [EC:1.14.13.87] +synonym: "(2S)-flavanone 2-hydroxylase activity" EXACT [EC:1.14.13.87] +synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" EXACT [EC:1.14.13.87] +xref: EC:1.14.13.87 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033772 +name: flavonoid 3',5'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.13.88] +synonym: "F3',5'H" RELATED [EC:1.14.13.88] +synonym: "F3'5'H" RELATED [EC:1.14.13.88] +synonym: "flavanone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.88] +xref: EC:1.14.13.88 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033773 +name: isoflavone 2'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an isoflavone + NADPH + H+ + O2 = a 2'-hydroxyisoflavone + NADP+ + H2O." [EC:1.14.13.89] +synonym: "CYP Ge-3" RELATED [EC:1.14.13.89] +synonym: "CYP81E1" RELATED [EC:1.14.13.89] +synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.89] +synonym: "isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating) activity" EXACT [EC:1.14.13.89] +xref: EC:1.14.13.89 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033774 +name: basal labyrinth +namespace: cellular_component +def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0045178 ! basal part of cell + +[Term] +id: GO:0033775 +name: deoxysarpagine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-deoxysarpagine + NADPH + H+ + O2 = sarpagine + NADP+ + H2O." [EC:1.14.13.91] +synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" EXACT [EC:1.14.13.91] +synonym: "DOSH" RELATED [EC:1.14.13.91] +xref: EC:1.14.13.91 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033776 +name: phenylacetone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O." [EC:1.14.13.92] +synonym: "PAMO" RELATED [EC:1.14.13.92] +synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.92] +xref: EC:1.14.13.92 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033777 +name: lithocholate 6beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: lithocholate + NADPH + H+ + O2 = 6beta-hydroxylithocholate + NADP+ + H2O." [EC:1.14.13.94] +synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.13.94] +synonym: "CYP3A10" RELATED [EC:1.14.13.94] +synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" EXACT [EC:1.14.13.94] +synonym: "lithocholate 6beta-monooxygenase activity" EXACT [EC:1.14.13.94] +synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" EXACT [EC:1.14.13.94] +xref: EC:1.14.13.94 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033778 +name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O." [EC:1.14.13.95] +synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95] +synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95] +synonym: "CYP12" RELATED [EC:1.14.13.95] +synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95] +synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95] +xref: EC:1.14.13.95 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033779 +name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + NADPH + H+ + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ + H2O." [EC:1.14.13.96] +synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" EXACT [EC:1.14.13.96] +synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.96] +synonym: "CYP8B1" RELATED [EC:1.14.13.96] +synonym: "cytochrome P450 8B1" RELATED [EC:1.14.13.96] +synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.96] +xref: EC:1.14.13.96 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033780 +name: taurochenodeoxycholate 6alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] +synonym: "CYP3A4" RELATED [EC:1.14.13.97] +synonym: "CYP4A21" RELATED [EC:1.14.13.97] +synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.13.97] +synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97] +xref: EC:1.14.13.97 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033781 +name: cholesterol 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.98] +synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.13.98] +synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.13.98] +synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.13.98] +synonym: "CYP46" RELATED [EC:1.14.13.98] +synonym: "CYP46A1" RELATED [EC:1.14.13.98] +synonym: "cytochrome P450 46A1" RELATED [EC:1.14.13.98] +xref: EC:1.14.13.98 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033782 +name: 24-hydroxycholesterol 7alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O." [EC:1.14.13.99] +synonym: "(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.99] +synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.99] +synonym: "CYP39A1" RELATED [EC:1.14.13.99] +synonym: "CYP39A1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.99] +xref: EC:1.14.13.99 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033783 +name: 25-hydroxycholesterol 7alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.13.100] +synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.100] +synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.100] +synonym: "CYP7B1" RELATED [EC:1.14.13.100] +synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.100] +xref: EC:1.14.13.100 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033784 +name: senecionine N-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O." [EC:1.14.13.101] +synonym: "senecionine monooxygenase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] +synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" EXACT [EC:1.14.13.101] +synonym: "SNO" RELATED [EC:1.14.13.101] +xref: EC:1.14.13.101 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033785 +name: heptose 7-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [MetaCyc:RXN0-4341] +subset: gosubset_prok +synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT [] +xref: EC:2.7.1.- +xref: IMG:02784 +xref: MetaCyc:RXN0-4341 +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0033786 +name: heptose 1-phosphate adenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342] +subset: gosubset_prok +synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT [] +xref: IMG:02786 +xref: MetaCyc:RXN0-4342 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0033787 +name: cyanocobalamin reductase (cyanide-eliminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: cob(I)alamin + cyanide + NADP+ = cyanocob(III)alamin + NADPH + H+." [EC:1.16.1.6] +synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.6] +synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" EXACT [EC:1.16.1.6] +synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" EXACT [EC:1.16.1.6] +synonym: "cyanocobalamin reductase activity" EXACT [EC:1.16.1.6] +synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] +synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6] +xref: EC:1.16.1.6 +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0033788 +name: leucoanthocyanidin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3] +synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.17.1.3] +synonym: "leucocyanidin reductase activity" EXACT [EC:1.17.1.3] +xref: EC:1.17.1.3 +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0033789 +name: phenylacetyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetyl-CoA + H2O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol." [EC:1.17.5.1] +synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.17.5.1] +synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" EXACT [EC:1.17.5.1] +xref: EC:1.17.5.1 +is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor + +[Term] +id: GO:0033790 +name: hydroxymethylfurfural reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033791 +name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3] +synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" EXACT [EC:1.17.99.3] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" EXACT [EC:1.17.99.3] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] +synonym: "THC-CoA oxidase activity" EXACT [EC:1.17.99.3] +synonym: "THCA-CoA oxidase activity" EXACT [EC:1.17.99.3] +synonym: "trihydroxycoprostanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3] +xref: EC:1.17.99.3 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0033792 +name: bile-acid 7alpha-dehydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2 and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5] +synonym: "7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] +synonym: "bile acid 7-dehydroxylase activity" EXACT [EC:1.17.99.5] +synonym: "cholate 7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5] +synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" EXACT [EC:1.17.99.5] +synonym: "deoxycholate:NAD+ oxidoreductase activity" EXACT [EC:1.17.99.5] +xref: EC:1.17.99.5 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0033793 +name: aureusidin synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6] +synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" EXACT [EC:1.21.3.6] +xref: EC:1.21.3.6 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0033794 +name: sarcosine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3] +synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" EXACT [EC:1.21.4.3] +xref: EC:1.21.4.3 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0033795 +name: betaine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4] +synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" EXACT [EC:1.21.4.4] +xref: EC:1.21.4.4 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0033796 +name: sulfur reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.97.1.3] +synonym: "(donor):sulfur oxidoreductase activity" EXACT [EC:1.97.1.3] +synonym: "sulphur reductase activity" EXACT [] +xref: EC:1.97.1.3 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0033797 +name: selenate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: selenite + H2O + acceptor = selenate + reduced acceptor." [EC:1.97.1.9] +synonym: "selenite:reduced acceptor oxidoreductase activity" EXACT [EC:1.97.1.9] +xref: EC:1.97.1.9 +xref: UM-BBD_enzymeID:e0508 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0033798 +name: thyroxine 5-deiodinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.97.1.11] +synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" EXACT [EC:1.97.1.11] +synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.97.1.11] +synonym: "iodothyronine 5-deiodinase activity" EXACT [EC:1.97.1.11] +synonym: "iodothyronine inner ring monodeiodinase activity" EXACT [EC:1.97.1.11] +synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.97.1.11] +xref: EC:1.97.1.11 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0033799 +name: myricetin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + myricetin = 2 S-adenosyl-L-homocysteine + syringetin." [EC:2.1.1.149] +synonym: "CrCOMT2" RELATED [EC:2.1.1.149] +synonym: "flavonoid 3',5'-O-dimethyltransferase activity" EXACT [EC:2.1.1.149] +synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" EXACT [EC:2.1.1.149] +xref: EC:2.1.1.149 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033800 +name: isoflavone 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150] +synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.150] +xref: EC:2.1.1.150 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033801 +name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153] +synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153] +xref: EC:2.1.1.153 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033802 +name: isoliquiritigenin 2'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin." [EC:2.1.1.154] +synonym: "chalcone OMT" RELATED [EC:2.1.1.154] +synonym: "CHMT" RELATED [EC:2.1.1.154] +synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" EXACT [EC:2.1.1.154] +xref: EC:2.1.1.154 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033803 +name: kaempferol 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide." [EC:2.1.1.155] +synonym: "F 4'-OMT" RELATED [EC:2.1.1.155] +synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] +synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155] +xref: EC:2.1.1.155 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033804 +name: glycine/sarcosine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156] +synonym: "ApGSMT" RELATED [EC:2.1.1.156] +synonym: "glycine sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] +synonym: "glycine-sarcosine methyltransferase activity" EXACT [EC:2.1.1.156] +synonym: "GMT" RELATED [EC:2.1.1.156] +synonym: "GSMT" RELATED [EC:2.1.1.156] +synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156] +xref: EC:2.1.1.156 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033805 +name: sarcosine/dimethylglycine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] +synonym: "ApDMT" RELATED [EC:2.1.1.157] +synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] +synonym: "sarcosine dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157] +synonym: "sarcosine-dimethylglycine methyltransferase activity" EXACT [EC:2.1.1.157] +synonym: "SDMT" RELATED [EC:2.1.1.157] +xref: EC:2.1.1.157 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033806 +name: fluorothreonine transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [EC:2.2.1.8] +synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" EXACT [EC:2.2.1.8] +xref: EC:2.2.1.8 +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0033807 +name: icosanoyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119] +synonym: "acyl-CoA elongase activity" EXACT [EC:2.3.1.119] +synonym: "C18-CoA elongase activity" EXACT [EC:2.3.1.119] +synonym: "stearoyl-CoA elongase activity" EXACT [EC:2.3.1.119] +synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" EXACT [EC:2.3.1.119] +xref: EC:2.3.1.119 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033808 +name: 6'-deoxychalcone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170] +synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" EXACT [EC:2.3.1.170] +xref: EC:2.3.1.170 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033809 +name: anthocyanin 6''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171] +synonym: "3MaT" RELATED [EC:2.3.1.171] +synonym: "Dv3MaT" RELATED [EC:2.3.1.171] +synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] +synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171] +xref: EC:2.3.1.171 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033810 +name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172] +synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" EXACT [EC:2.3.1.172] +synonym: "Ss5MaT1" RELATED [EC:2.3.1.172] +xref: EC:2.3.1.172 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033811 +name: flavonol-3-O-triglucoside O-coumaroyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173] +synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" EXACT [EC:2.3.1.173] +xref: EC:2.3.1.173 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033812 +name: 3-oxoadipyl-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174] +synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" EXACT [EC:2.3.1.174] +xref: EC:2.3.1.174 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033813 +name: deacetylcephalosporin-C acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C." [EC:2.3.1.175] +synonym: "acetyl coenzyme A:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] +synonym: "acetyl-CoA:DAC acetyltransferase activity" EXACT [EC:2.3.1.175] +synonym: "acetyl-CoA:DAC O-acetyltransferase activity" EXACT [EC:2.3.1.175] +synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" EXACT [EC:2.3.1.175] +synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" EXACT [EC:2.3.1.175] +synonym: "cefG" RELATED [EC:2.3.1.175] +synonym: "CPC acetylhydrolase activity" EXACT [EC:2.3.1.175] +synonym: "DAC acetyltransferase activity" EXACT [EC:2.3.1.175] +synonym: "DAC-AT" RELATED [EC:2.3.1.175] +synonym: "deacetylcephalosporin C acetyltransferase activity" EXACT [EC:2.3.1.175] +xref: EC:2.3.1.175 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0033814 +name: propanoyl-CoA C-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.176] +synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176] +synonym: "PTE-2" RELATED [EC:2.3.1.176] +synonym: "SCP-X" RELATED [EC:2.3.1.176] +synonym: "SCPchi" RELATED [EC:2.3.1.176] +synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176] +synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176] +xref: EC:2.3.1.176 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0033815 +name: biphenyl synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177] +synonym: "BIS" RELATED [EC:2.3.1.177] +synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.177] +xref: EC:2.3.1.177 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033816 +name: diaminobutyrate acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-2,4-diaminobutanoate = CoA + N4-acetyl-L-2,4-diaminobutanoate." [EC:2.3.1.178] +synonym: "2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "DAB acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "DABA acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "DABAcT" RELATED [EC:2.3.1.178] +synonym: "diaminobutyric acid acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "EctA" RELATED [EC:2.3.1.178] +synonym: "L-2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178] +synonym: "L-2,4-diaminobutyrate acetyltransferase activity" EXACT [EC:2.3.1.178] +xref: EC:2.3.1.178 +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0033817 +name: beta-ketoacyl-acyl-carrier-protein synthase II activity +namespace: molecular_function +def: "Catalysis of the reaction: (Z)-hexadec-11-enoyl-acyl-carrier-protein + malonyl-acyl-carrier-protein = (Z)-3-oxooctadec-13-enoyl-acyl-carrier-protein + CO2 + acyl-carrier-protein." [EC:2.3.1.179] +synonym: "(Z)-hexadec-11-enoyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.179] +synonym: "3-oxoacyl-acyl carrier protein synthase I activity" EXACT [EC:2.3.1.179] +synonym: "beta-ketoacyl-ACP synthase II activity" EXACT [EC:2.3.1.179] +synonym: "FabF" RELATED [EC:2.3.1.179] +synonym: "KAS II" RELATED [EC:2.3.1.179] +synonym: "KASII" RELATED [EC:2.3.1.179] +xref: EC:2.3.1.179 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033818 +name: beta-ketoacyl-acyl-carrier-protein synthase III activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + malonyl-acyl-carrier-protein = acetoacyl-acyl-carrier-protein + CoA + CO2." [EC:2.3.1.180] +synonym: "3-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] +synonym: "3-oxoacyl:ACP synthase III activity" EXACT [EC:2.3.1.180] +synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" EXACT [EC:2.3.1.180] +synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" EXACT [EC:2.3.1.180] +synonym: "beta-ketoacyl-ACP synthase III activity" EXACT [EC:2.3.1.180] +synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180] +synonym: "FabH" RELATED [EC:2.3.1.180] +synonym: "KAS III" RELATED [EC:2.3.1.180] +synonym: "KASIII" RELATED [EC:2.3.1.180] +xref: EC:2.3.1.180 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033819 +name: lipoyl(octanoyl) transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-acyl-carrier-protein + protein = protein N6-(octanoyl)lysine + acyl carrier protein." [EC:2.3.1.181] +synonym: "LipB" RELATED [EC:2.3.1.181] +synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181] +synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181] +synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181] +synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] +synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] +synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181] +xref: EC:2.3.1.181 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0033820 +name: DNA alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26] +synonym: "T2-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] +synonym: "T4-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] +synonym: "T6-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26] +synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.26] +synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] +synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26] +xref: EC:2.4.1.26 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033821 +name: DNA beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27] +synonym: "T4 phage beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] +synonym: "T4-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] +synonym: "T4-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27] +synonym: "UDP glucose-DNA beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] +synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] +synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27] +synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.27] +xref: EC:2.4.1.27 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033822 +name: glucosyl-DNA beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28] +synonym: "T6-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] +synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28] +synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] +synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28] +synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.28] +xref: EC:2.4.1.28 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033823 +name: procollagen glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66] +synonym: "collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "collagen hydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "galactosylhydroxylysine glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "galactosylhydroxylysine-glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "galactosylhydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "UDP-glucose-collagenglucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66] +synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT [EC:2.4.1.66] +xref: EC:2.4.1.66 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033824 +name: alternansucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers alternately an alpha-D-glucosyl residue from sucrose to the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140] +synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.140] +synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.140] +synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140] +xref: EC:2.4.1.140 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033825 +name: oligosaccharide 4-alpha-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161] +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.161] +synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.161] +synonym: "amylase III activity" EXACT [EC:2.4.1.161] +xref: EC:2.4.1.161 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033826 +name: xyloglucan 4-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168] +synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] +synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] +synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" EXACT [EC:2.4.1.168] +synonym: "xyloglucan 4beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168] +synonym: "xyloglucan glucosyltransferase activity" EXACT [EC:2.4.1.168] +xref: EC:2.4.1.168 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033827 +name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197] +synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] +synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] +synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] +synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197] +xref: EC:2.4.1.197 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0033828 +name: glucosylglycerol-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-glucose + sn-glycerol 3-phosphate = 2-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP." [EC:2.4.1.213] +synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] +synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213] +synonym: "GG-phosphate synthase activity" EXACT [EC:2.4.1.213] +synonym: "GGPS" RELATED [EC:2.4.1.213] +synonym: "glucosyl-glycerol-phosphate synthase activity" EXACT [EC:2.4.1.213] +xref: EC:2.4.1.213 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033829 +name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222] +synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.222] +synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.222] +xref: EC:2.4.1.222 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0033830 +name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229] +synonym: "Skp1-HyPro GlcNAc-transferase activity" EXACT [EC:2.4.1.229] +synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] +synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:2.4.1.229] +synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229] +synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229] +xref: EC:2.4.1.229 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0033831 +name: kojibiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-alpha-D-glucosyl-D-glucose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.230] +synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.230] +xref: EC:2.4.1.230 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033832 +name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231] +synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231] +synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231] +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033833 +name: hydroxymethylfurfural reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] +is_a: GO:0033790 ! hydroxymethylfurfural reductase activity + +[Term] +id: GO:0033834 +name: kaempferol 3-O-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234] +synonym: "F3GalTase activity" EXACT [EC:2.4.1.234] +synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234] +xref: EC:2.4.1.234 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0033835 +name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236] +synonym: "1->2 UDP-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] +synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] +synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" EXACT [EC:2.4.1.236] +xref: EC:2.4.1.236 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0033836 +name: flavonol 7-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237] +synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.237] +synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.237] +xref: EC:2.4.1.237 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033837 +name: anthocyanin 3'-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238] +synonym: "3'GT" RELATED [EC:2.4.1.238] +synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.238] +synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238] +xref: EC:2.4.1.238 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033838 +name: flavonol-3-O-glucoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239] +synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.239] +xref: EC:2.4.1.239 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033839 +name: flavonol-3-O-glycoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240] +synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.240] +xref: EC:2.4.1.240 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033840 +name: NDP-glucose-starch glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242] +synonym: "GBSS" RELATED [EC:2.4.1.242] +synonym: "GBSSI" RELATED [EC:2.4.1.242] +synonym: "GBSSII" RELATED [EC:2.4.1.242] +synonym: "granule-bound starch synthase activity" EXACT [EC:2.4.1.242] +synonym: "granule-bound starch synthase I activity" EXACT [EC:2.4.1.242] +synonym: "granule-bound starch synthase II activity" EXACT [EC:2.4.1.242] +synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.242] +synonym: "NDPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] +synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242] +synonym: "starch synthase II activity" EXACT [EC:2.4.1.242] +synonym: "waxy protein" RELATED [EC:2.4.1.242] +xref: EC:2.4.1.242 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033841 +name: 6G-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243] +synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" EXACT [EC:2.4.1.243] +synonym: "6G-FFT" RELATED [EC:2.4.1.243] +synonym: "6G-fructotransferase activity" EXACT [EC:2.4.1.243] +synonym: "6G-FT" RELATED [EC:2.4.1.243] +synonym: "fructan:fructan 6G-fructosyltransferase activity" EXACT [EC:2.4.1.243] +xref: EC:2.4.1.243 +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0033842 +name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] +synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] +synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" EXACT [EC:2.4.1.244] +synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" EXACT [EC:2.4.1.244] +synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244] +synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244] +synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244] +xref: EC:2.4.1.244 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0033843 +name: xyloglucan 6-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39] +synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] +synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" EXACT [EC:2.4.2.39] +synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39] +xref: EC:2.4.2.39 +is_a: GO:0042285 ! xylosyltransferase activity + +[Term] +id: GO:0033844 +name: galactose-6-sulfurylase activity +namespace: molecular_function +def: "Catalysis of the reaction: Eliminates sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5] +synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" EXACT [EC:2.5.1.5] +synonym: "galactose 6-sulfatase activity" EXACT [EC:2.5.1.5] +synonym: "galactose-6-sulfatase activity" EXACT [EC:2.5.1.5] +synonym: "porphyran sulfatase activity" EXACT [EC:2.5.1.5] +xref: EC:2.5.1.5 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033845 +name: hydroxymethylfurfural reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] +is_a: GO:0033790 ! hydroxymethylfurfural reductase activity + +[Term] +id: GO:0033846 +name: adenosyl-fluoride synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63] +synonym: "fluorinase activity" EXACT [EC:2.5.1.63] +synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" EXACT [EC:2.5.1.63] +xref: EC:2.5.1.63 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033847 +name: O-phosphoserine sulfhydrylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65] +synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.65] +synonym: "O-phosphoserine(thiol)-lyase activity" EXACT [EC:2.5.1.65] +xref: EC:2.5.1.65 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033848 +name: N2-(2-carboxyethyl)arginine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate." [EC:2.5.1.66] +synonym: "CEA synthetase activity" EXACT [EC:2.5.1.66] +synonym: "CEAS" RELATED [EC:2.5.1.66] +synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] +synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66] +synonym: "N2-(2-carboxyethyl)arginine synthetase activity" EXACT [EC:2.5.1.66] +xref: EC:2.5.1.66 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033849 +name: chrysanthemyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + chrysanthemyl diphosphate." [EC:2.5.1.67] +synonym: "CPPase activity" EXACT [EC:2.5.1.67] +synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" EXACT [EC:2.5.1.67] +xref: EC:2.5.1.67 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033850 +name: Z-farnesyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate." [EC:2.5.1.68] +synonym: "(Z)-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.68] +synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" EXACT [EC:2.5.1.68] +xref: EC:2.5.1.68 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033851 +name: lavandulyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69] +synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" EXACT [EC:2.5.1.69] +synonym: "FDS-5" RELATED [EC:2.5.1.69] +xref: EC:2.5.1.69 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033852 +name: thyroid-hormone transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate." [EC:2.6.1.26] +synonym: "3,5-dinitrotyrosine aminotransferase activity" EXACT [EC:2.6.1.26] +synonym: "3,5-dinitrotyrosine transaminase activity" EXACT [EC:2.6.1.26] +synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.26] +synonym: "thyroid hormone aminotransferase activity" EXACT [EC:2.6.1.26] +synonym: "thyroid-hormone aminotransferase activity" EXACT [EC:2.6.1.26] +xref: EC:2.6.1.26 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033853 +name: aspartate-prephenate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78] +synonym: "L-arogenate:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.78] +synonym: "L-aspartate:prephenate aminotransferase activity" EXACT [EC:2.6.1.78] +synonym: "PAT" RELATED [EC:2.6.1.78] +synonym: "prephenate aspartate aminotransferase activity" EXACT [EC:2.6.1.78] +synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78] +xref: EC:2.6.1.78 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033854 +name: glutamate-prephenate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + 2-oxoglutarate = prephenate + L-glutamate." [EC:2.6.1.79] +synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.79] +synonym: "L-glutamate:prephenate aminotransferase activity" EXACT [EC:2.6.1.79] +synonym: "PAT" RELATED [EC:2.6.1.79] +synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79] +xref: EC:2.6.1.79 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033855 +name: nicotianamine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80] +synonym: "NAAT" RELATED [EC:2.6.1.80] +synonym: "NAAT-I" RELATED [EC:2.6.1.80] +synonym: "NAAT-II" RELATED [EC:2.6.1.80] +synonym: "NAAT-III" RELATED [EC:2.6.1.80] +synonym: "nicotianamine transaminase activity" EXACT [EC:2.6.1.80] +synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.80] +xref: EC:2.6.1.80 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033856 +name: pyridoxine 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O." [EC:2.6.99.2] +synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" EXACT [EC:2.6.99.2] +synonym: "PdxJ" RELATED [EC:2.6.99.2] +synonym: "PNP synthase activity" EXACT [EC:2.6.99.2] +synonym: "pyridoxine 5-phosphate phospho lyase activity" EXACT [EC:2.6.99.2] +xref: EC:2.6.99.2 +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0033857 +name: diphosphoinositol-pentakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.24] +synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.24] +synonym: "PP-InsP5 kinase activity" EXACT [EC:2.7.4.24] +synonym: "PP-IP5 kinase activity" EXACT [EC:2.7.4.24] +synonym: "PPIP5K" RELATED [EC:2.7.4.24] +synonym: "PPIP5K1" RELATED [EC:2.7.4.24] +synonym: "PPIP5K2" RELATED [EC:2.7.4.24] +synonym: "VIP1" NARROW [EC:2.7.4.24] +synonym: "VIP2" NARROW [EC:2.7.4.24] +xref: EC:2.7.4.24 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0033858 +name: N-acetylgalactosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] +synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" EXACT [EC:2.7.1.157] +synonym: "GALK2" RELATED [EC:2.7.1.157] +synonym: "GalNAc kinase activity" EXACT [EC:2.7.1.157] +synonym: "GK2" RELATED [EC:2.7.1.157] +synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157] +xref: EC:2.7.1.157 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0033859 +name: furaldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0033860 +name: regulation of NAD(P)H oxidase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0033861 +name: negative regulation of NAD(P)H oxidase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "down-regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "downregulation of NAD(P)H oxidase activity" EXACT [] +synonym: "inhibition of NAD(P)H oxidase activity" NARROW [] +is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity +is_a: GO:0051354 ! negative regulation of oxidoreductase activity + +[Term] +id: GO:0033862 +name: UMP kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22] +synonym: "ATP:UMP phosphotransferase activity" EXACT [EC:2.7.4.22] +synonym: "PyrH" RELATED [EC:2.7.4.22] +synonym: "SmbA" RELATED [EC:2.7.4.22] +synonym: "UMP-kinase activity" EXACT [EC:2.7.4.22] +synonym: "UMPK" RELATED [EC:2.7.4.22] +synonym: "uridine monophosphate kinase activity" EXACT [EC:2.7.4.22] +xref: EC:2.7.4.22 +is_a: GO:0009041 ! uridylate kinase activity + +[Term] +id: GO:0033863 +name: ribose 1,5-bisphosphate phosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.4.23] +synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" EXACT [EC:2.7.4.23] +synonym: "PhnN" RELATED [EC:2.7.4.23] +synonym: "ribose 1,5-bisphosphokinase activity" EXACT [EC:2.7.4.23] +xref: EC:2.7.4.23 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0033864 +name: positive regulation of NAD(P)H oxidase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah] +subset: gosubset_prok +synonym: "activation of NAD(P)H oxidase activity" NARROW [] +synonym: "stimulation of NAD(P)H oxidase activity" NARROW [] +synonym: "up regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "up-regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "upregulation of NAD(P)H oxidase activity" EXACT [] +is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity +is_a: GO:0051353 ! positive regulation of oxidoreductase activity + +[Term] +id: GO:0033865 +name: nucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "nucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0033866 +name: nucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "nucleoside bisphosphate anabolism" EXACT [] +synonym: "nucleoside bisphosphate biosynthesis" EXACT [] +synonym: "nucleoside bisphosphate formation" EXACT [] +synonym: "nucleoside bisphosphatehate synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process + +[Term] +id: GO:0033867 +name: Fas-activated serine/threonine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8] +synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" EXACT [EC:2.7.11.8] +synonym: "FAST" RELATED [EC:2.7.11.8] +synonym: "FASTK" RELATED [EC:2.7.11.8] +synonym: "STK10" RELATED [EC:2.7.11.8] +xref: EC:2.7.11.8 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0033868 +name: Goodpasture-antigen-binding protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] +synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" EXACT [EC:2.7.11.9] +synonym: "Goodpasture antigen-binding protein kinase activity" EXACT [EC:2.7.11.9] +synonym: "GPBP kinase activity" EXACT [EC:2.7.11.9] +synonym: "GPBPK" RELATED [EC:2.7.11.9] +synonym: "STK11" RELATED [EC:2.7.11.9] +xref: EC:2.7.11.9 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0033869 +name: nucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "nucleoside bisphosphate breakdown" EXACT [] +synonym: "nucleoside bisphosphate catabolism" EXACT [] +synonym: "nucleoside bisphosphate degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process + +[Term] +id: GO:0033870 +name: thiol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16] +synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" EXACT [EC:2.8.2.16] +synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" EXACT [EC:2.8.2.16] +synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16] +xref: EC:2.8.2.16 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033871 +name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29] +synonym: "3-OST-2" RELATED [EC:2.8.2.29] +synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] +synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] +synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED [] +synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29] +xref: EC:2.8.2.29 +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0033872 +name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30] +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30] +synonym: "3-OST-3" RELATED [EC:2.8.2.30] +synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] +synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" EXACT [EC:2.8.2.30] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" EXACT [EC:2.8.2.30] +synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED [] +synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30] +xref: EC:2.8.2.30 +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0033873 +name: petromyzonol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol = adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate." [EC:2.8.2.31] +synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" EXACT [EC:2.8.2.31] +synonym: "PZ-SULT" RELATED [EC:2.8.2.31] +xref: EC:2.8.2.31 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033874 +name: scymnol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol = adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate." [EC:2.8.2.32] +xref: EC:2.8.2.32 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033875 +name: ribonucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "ribonucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process + +[Term] +id: GO:0033876 +name: glycochenodeoxycholate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate." [EC:2.8.2.34] +synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" EXACT [EC:2.8.2.34] +synonym: "BAST" RELATED [EC:2.8.2.34] +synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34] +synonym: "bile acid:PAPS:sulfotransferase activity" EXACT [EC:2.8.2.34] +xref: EC:2.8.2.34 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033877 +name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity +namespace: molecular_function +alt_id: GO:0018728 +def: "Catalysis of the reaction: succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA." [EC:2.8.3.15] +synonym: "benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] +synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15] +synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT [] +xref: EC:2.8.3.15 +xref: UM-BBD_enzymeID:e0260 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0033878 +name: hormone-sensitive lipase activity +namespace: molecular_function +def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate, triacylglycerol + H2O = diacylglycerol + a carboxylate, and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79] +synonym: "diacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.79] +synonym: "HSL" RELATED [EC:3.1.1.79] +xref: EC:3.1.1.79 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0033879 +name: acetylajmaline esterase activity +namespace: molecular_function +def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80] +synonym: "17-O-acetylajmaline O-acetylhydrolase activity" EXACT [EC:3.1.1.80] +synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" EXACT [EC:3.1.1.80] +synonym: "AAE" RELATED [EC:3.1.1.80] +synonym: "acetylajmalan esterase activity" EXACT [EC:3.1.1.80] +xref: EC:3.1.1.80 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0033880 +name: phenylacetyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA." [EC:3.1.2.25] +synonym: "phenylglyoxylyl-CoA hydrolase activity" EXACT [EC:3.1.2.25] +xref: EC:3.1.2.25 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0033881 +name: bile-acid-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxycholoyl-CoA + H2O = CoA + deoxycholate." [EC:3.1.2.26] +synonym: "bile acid-coenzyme A hydrolase activity" EXACT [EC:3.1.2.26] +synonym: "deoxycholoyl-CoA hydrolase activity" EXACT [EC:3.1.2.26] +xref: EC:3.1.2.26 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0033882 +name: choloyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27] +synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] +synonym: "choloyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27] +synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27] +synonym: "PTE-2" RELATED [EC:3.1.2.27] +xref: EC:3.1.2.27 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0033883 +name: pyridoxal phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] +synonym: "PLP phosphatase activity" EXACT [EC:3.1.3.74] +synonym: "PNP phosphatase activity" EXACT [EC:3.1.3.74] +synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.74] +synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74] +synonym: "vitamine B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74] +xref: EC:3.1.3.74 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0033884 +name: phosphoethanolamine/phosphocholine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75] +synonym: "3X11A" RELATED [EC:3.1.3.75] +synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] +synonym: "phosphoethanolamine phosphohydrolase activity" EXACT [EC:3.1.3.75] +xref: EC:3.1.3.75 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0033885 +name: lipid-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76] +synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT [EC:3.1.3.76] +synonym: "dihydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76] +synonym: "hydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76] +synonym: "hydroxy lipid phosphatase activity" EXACT [EC:3.1.3.76] +synonym: "sEH" RELATED [EC:3.1.3.76] +synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76] +xref: EC:3.1.3.76 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0033886 +name: cellulose-polysulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7] +synonym: "cellulose-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.7] +xref: EC:3.1.6.7 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033887 +name: chondro-4-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate." [EC:3.1.6.9] +synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.9] +xref: EC:3.1.6.9 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033888 +name: chondro-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate." [EC:3.1.6.10] +synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.10] +xref: EC:3.1.6.10 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033889 +name: N-sulfoglucosamine-3-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15] +synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15] +synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" EXACT [EC:3.1.6.15] +xref: EC:3.1.6.15 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033890 +name: ribonuclease D activity +namespace: molecular_function +def: "Catalysis of the reaction: exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5] +synonym: "RNase D activity" EXACT [EC:3.1.13.5] +xref: EC:3.1.13.5 +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033891 +name: CC-preferring endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6] +synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] +synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" EXACT [EC:3.1.21.6] +synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" EXACT [EC:3.1.21.6] +synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" EXACT [EC:3.1.21.6] +xref: EC:3.1.21.6 +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033892 +name: deoxyribonuclease (pyrimidine dimer) activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1] +synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1] +synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1] +synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1] +xref: EC:3.1.25.1 +is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base + +[Term] +id: GO:0033893 +name: ribonuclease IV activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6] +synonym: "endoribonuclease IV activity" EXACT [EC:3.1.26.6] +xref: EC:3.1.26.6 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033894 +name: ribonuclease P4 activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7] +xref: EC:3.1.26.7 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033895 +name: ribonuclease [poly-(U)-specific] activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9] +synonym: "ribonuclease (uracil-specific) activity" EXACT [EC:3.1.26.9] +synonym: "uracil-specific endoribonuclease activity" EXACT [EC:3.1.26.9] +synonym: "uracil-specific RNase activity" EXACT [EC:3.1.26.9] +xref: EC:3.1.26.9 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033896 +name: ribonuclease IX activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10] +synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" EXACT [EC:3.1.26.10] +xref: EC:3.1.26.10 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033897 +name: ribonuclease T2 activity +namespace: molecular_function +def: "Catalysis of the reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1] +synonym: "acid ribonuclease activity" EXACT [EC:3.1.27.1] +synonym: "acid RNase activity" EXACT [EC:3.1.27.1] +synonym: "base-non-specific ribonuclease activity" EXACT [EC:3.1.27.1] +synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [EC:3.1.27.1] +synonym: "Escherichia coli ribonuclease II activity" EXACT [EC:3.1.27.1] +synonym: "non-base specific ribonuclease activity" EXACT [EC:3.1.27.1] +synonym: "nonbase-specific RNase activity" EXACT [EC:3.1.27.1] +synonym: "nonspecific RNase activity" EXACT [EC:3.1.27.1] +synonym: "ribonnuclease (non-base specific) activity" EXACT [EC:3.1.27.1] +synonym: "ribonuclease (non-base specific) activity" EXACT [EC:3.1.27.1] +synonym: "ribonuclease II activity" BROAD [EC:3.1.27.1] +synonym: "ribonuclease M activity" EXACT [EC:3.1.27.1] +synonym: "ribonuclease N2 activity" EXACT [EC:3.1.27.1] +synonym: "ribonuclease PP3 activity" EXACT [EC:3.1.27.1] +synonym: "ribonuclease U4 activity" EXACT [EC:3.1.27.1] +synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [EC:3.1.27.1] +synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.1] +synonym: "RNAase CL activity" EXACT [EC:3.1.27.1] +synonym: "RNase (non-base specific) activity" EXACT [EC:3.1.27.1] +synonym: "RNase II activity" BROAD [EC:3.1.27.1] +synonym: "RNase M activity" EXACT [EC:3.1.27.1] +synonym: "RNase Ms activity" EXACT [EC:3.1.27.1] +synonym: "RNase T2 activity" EXACT [EC:3.1.27.1] +xref: EC:3.1.27.1 +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033898 +name: Bacillus subtilis ribonuclease activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:3.1.27.2] +synonym: "proteus mirabilis RNase activity" EXACT [EC:3.1.27.2] +synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.2] +xref: EC:3.1.27.2 +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033899 +name: ribonuclease U2 activity +namespace: molecular_function +def: "Catalysis of the reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.4] +synonym: "pleospora RNase activity" EXACT [EC:3.1.27.4] +synonym: "purine specific endoribonuclease activity" EXACT [EC:3.1.27.4] +synonym: "purine-specific ribonuclease activity" EXACT [EC:3.1.27.4] +synonym: "purine-specific RNase activity" EXACT [EC:3.1.27.4] +synonym: "ribonuclease (purine) activity" EXACT [EC:3.1.27.4] +synonym: "ribonuclease U3 activity" EXACT [EC:3.1.27.4] +synonym: "RNase U3 activity" EXACT [EC:3.1.27.4] +synonym: "trichoderma koningi RNase III activity" EXACT [EC:3.1.27.4] +xref: EC:3.1.27.4 +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033900 +name: ribonuclease F activity +namespace: molecular_function +def: "Catalysis of the reaction: endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7] +synonym: "ribonuclease F (E. coli) activity" EXACT [EC:3.1.27.7] +synonym: "RNase F activity" EXACT [EC:3.1.27.7] +xref: EC:3.1.27.7 +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033901 +name: ribonuclease V activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8] +synonym: "endoribonuclease V activity" EXACT [EC:3.1.27.8] +xref: EC:3.1.27.8 +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033902 +name: rRNA endonuclease activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [EC:3.1.27.10] +synonym: "alpha-sarcin" RELATED [EC:3.1.27.10] +xref: EC:3.1.27.10 +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033903 +name: endo-1,3(4)-beta-glucanase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] +synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" EXACT [EC:3.2.1.6] +synonym: "beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] +synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-1,3-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.6] +synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-beta-(1-3)-D-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-beta-1,3(4)-glucanase activity" EXACT [EC:3.2.1.6] +synonym: "endo-beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6] +synonym: "endo-beta-1,3-glucanase IV activity" EXACT [EC:3.2.1.6] +synonym: "laminaranase activity" BROAD [EC:3.2.1.6] +synonym: "laminarinase activity" BROAD [EC:3.2.1.6] +xref: EC:3.2.1.6 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033904 +name: dextranase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11] +synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.11] +synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] +synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11] +synonym: "dextran hydrolase activity" EXACT [EC:3.2.1.11] +synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11] +synonym: "DL 2" RELATED [EC:3.2.1.11] +synonym: "endo-dextranase activity" EXACT [EC:3.2.1.11] +synonym: "endodextranase activity" EXACT [EC:3.2.1.11] +xref: EC:3.2.1.11 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033905 +name: xylan endo-1,3-beta-xylosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: random hydrolysis of 1,3-beta-D-glycosidic linkages in 1,3-beta-D-xylans." [EC:3.2.1.32] +synonym: "1,3-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.32] +synonym: "1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] +synonym: "1,3-xylanase activity" EXACT [EC:3.2.1.32] +synonym: "beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] +synonym: "endo-1,3-beta-xylanase activity" EXACT [EC:3.2.1.32] +synonym: "endo-1,3-xylanase activity" EXACT [EC:3.2.1.32] +synonym: "endo-beta-1,3-xylanase activity" EXACT [EC:3.2.1.32] +synonym: "xylanase activity" BROAD [EC:3.2.1.32] +xref: EC:3.2.1.32 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033906 +name: hyaluronoglucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36] +synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" EXACT [EC:3.2.1.36] +synonym: "hyaluronate 3-glycanohydrolase activity" EXACT [EC:3.2.1.36] +synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36] +synonym: "orgelase activity" EXACT [EC:3.2.1.36] +xref: EC:3.2.1.36 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033907 +name: beta-D-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38] +synonym: "beta-D-fucoside fucohydrolase activity" EXACT [EC:3.2.1.38] +synonym: "beta-fucosidase activity" EXACT [EC:3.2.1.38] +xref: EC:3.2.1.38 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033908 +name: beta-L-rhamnosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43] +synonym: "beta-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.43] +xref: EC:3.2.1.43 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033909 +name: fucoidanase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [EC:3.2.1.44] +synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" EXACT [EC:3.2.1.44] +xref: EC:3.2.1.44 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033910 +name: glucan 1,4-alpha-maltotetraohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60] +synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" EXACT [EC:3.2.1.60] +synonym: "exo-maltotetraohydrolase activity" EXACT [EC:3.2.1.60] +synonym: "G4-amylase activity" EXACT [EC:3.2.1.60] +synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" EXACT [EC:3.2.1.60] +synonym: "maltotetraose-forming amylase activity" EXACT [EC:3.2.1.60] +xref: EC:3.2.1.60 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033911 +name: mycodextranase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61] +synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.61] +xref: EC:3.2.1.61 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033912 +name: 2,6-beta-fructan 6-levanbiohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 2,6-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64] +synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" EXACT [EC:3.2.1.64] +synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] +synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" EXACT [EC:3.2.1.64] +synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" EXACT [EC:3.2.1.64] +synonym: "levanbiose-producing levanase activity" EXACT [EC:3.2.1.64] +xref: EC:3.2.1.64 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033913 +name: glucan endo-1,2-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: random hydrolysis of 1,2-glucosidic linkages in 1,2-beta-D-glucans." [EC:3.2.1.71] +synonym: "1,2-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.71] +synonym: "beta-D-1,2-glucanase activity" EXACT [EC:3.2.1.71] +synonym: "endo-(1->2)-beta-D-glucanase activity" EXACT [EC:3.2.1.71] +synonym: "endo-1,2-beta-glucanase activity" EXACT [EC:3.2.1.71] +xref: EC:3.2.1.71 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033914 +name: xylan 1,3-beta-xylosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of successive xylose residues from the non-reducing termini of 1,3-beta-D-xylans." [EC:3.2.1.72] +synonym: "1,3-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.72] +synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] +synonym: "beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] +synonym: "exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72] +synonym: "exo-beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72] +xref: EC:3.2.1.72 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033915 +name: mannan 1,2-(1,3)-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,2- and 1,3-linkages in yeast mannan, releasing mannose." [EC:3.2.1.77] +synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" EXACT [EC:3.2.1.77] +synonym: "exo-1,2-1,3-alpha-mannosidase activity" EXACT [EC:3.2.1.77] +xref: EC:3.2.1.77 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033916 +name: beta-agarase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81] +synonym: "AgaA" RELATED [EC:3.2.1.81] +synonym: "AgaB" RELATED [EC:3.2.1.81] +synonym: "agarase activity" BROAD [EC:3.2.1.81] +synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81] +synonym: "agarose 4-glycanohydrolase activity" EXACT [EC:3.2.1.81] +xref: EC:3.2.1.81 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033917 +name: exo-poly-alpha-galacturonosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82] +synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82] +synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82] +xref: EC:3.2.1.82 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033918 +name: kappa-carrageenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83] +synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" EXACT [EC:3.2.1.83] +synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" EXACT [EC:3.2.1.83] +xref: EC:3.2.1.83 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033919 +name: glucan 1,3-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal 1,3-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] +synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" EXACT [EC:3.2.1.84] +synonym: "exo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.84] +synonym: "glucosidase II activity" EXACT [EC:3.2.1.84] +xref: EC:3.2.1.84 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033920 +name: 6-phospho-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85] +synonym: "6-phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] +synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" EXACT [EC:3.2.1.85] +synonym: "beta-D-phosphogalactoside galactohydrolase activity" EXACT [EC:3.2.1.85] +synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85] +synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85] +xref: EC:3.2.1.85 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033921 +name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: random hydrolysis of 1,3-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87] +synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] +synonym: "capsular polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87] +synonym: "polysaccharide depolymerase activity" EXACT [EC:3.2.1.87] +xref: EC:3.2.1.87 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033922 +name: peptidoglycan beta-N-acetylmuramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92] +synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" EXACT [EC:3.2.1.92] +synonym: "exo-beta-acetylmuramidase activity" EXACT [EC:3.2.1.92] +synonym: "exo-beta-N-acetylmuramidase activity" EXACT [EC:3.2.1.92] +synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" EXACT [EC:3.2.1.92] +xref: EC:3.2.1.92 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033923 +name: glucan 1,6-alpha-isomaltosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94] +synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" EXACT [EC:3.2.1.94] +synonym: "exo-isomaltohydrolase activity" EXACT [EC:3.2.1.94] +synonym: "G2-dextranase activity" EXACT [EC:3.2.1.94] +synonym: "isomalto-dextranase activity" EXACT [EC:3.2.1.94] +synonym: "isomaltodextranase activity" EXACT [EC:3.2.1.94] +xref: EC:3.2.1.94 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033924 +name: dextran 1,6-alpha-isomaltotriosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95] +synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] +synonym: "exo-isomaltotriohydrolase activity" EXACT [EC:3.2.1.95] +xref: EC:3.2.1.95 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033925 +name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96] +synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase D activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase F activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase H activity" EXACT [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase L activity" EXACT [EC:3.2.1.96] +synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.96] +synonym: "endo-N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.96] +synonym: "endoglycosidase H activity" EXACT [EC:3.2.1.96] +synonym: "endoglycosidase S activity" EXACT [EC:3.2.1.96] +synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] +synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96] +synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" EXACT [EC:3.2.1.96] +synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" EXACT [EC:3.2.1.96] +synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96] +xref: EC:3.2.1.96 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033926 +name: glycopeptide alpha-N-acetylgalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal D-galactosyl-N-acetyl-alpha-D-galactosaminidic residues from a variety of glycopeptides and glycoproteins." [EC:3.2.1.97] +synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" EXACT [EC:3.2.1.97] +synonym: "endo-alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.97] +synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] +xref: EC:3.2.1.97 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033927 +name: glucan 1,4-alpha-maltohexaosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98] +synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" EXACT [EC:3.2.1.98] +synonym: "exo-maltohexaohydrolase activity" EXACT [EC:3.2.1.98] +synonym: "G6-amylase activity" EXACT [EC:3.2.1.98] +synonym: "maltohexaose-producing amylase activity" EXACT [EC:3.2.1.98] +xref: EC:3.2.1.98 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033928 +name: mannan 1,4-mannobiosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-mannosidic linkages in 1,4-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100] +synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100] +synonym: "exo-1,4-beta-mannobiohydrolase activity" EXACT [EC:3.2.1.100] +synonym: "exo-beta-mannanase activity" EXACT [EC:3.2.1.100] +synonym: "mannan 1,4-beta-mannobiosidase activity" EXACT [EC:3.2.1.100] +xref: EC:3.2.1.100 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033929 +name: blood-group-substance endo-1,4-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102] +synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.102] +synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102] +xref: EC:3.2.1.102 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033930 +name: keratan-sulfate endo-1,4-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103] +synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103] +synonym: "keratan sulfate endogalactosidase activity" EXACT [EC:3.2.1.103] +synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.103] +synonym: "keratanase activity" EXACT [EC:3.2.1.103] +xref: EC:3.2.1.103 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033931 +name: endogalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109] +synonym: "galactosaminoglycan glycanohydrolase activity" EXACT [EC:3.2.1.109] +xref: EC:3.2.1.109 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033932 +name: 1,3-alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,3-linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111] +synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" EXACT [EC:3.2.1.111] +synonym: "almond emulsin fucosidase I activity" EXACT [EC:3.2.1.111] +xref: EC:3.2.1.111 +is_a: GO:0004560 ! alpha-L-fucosidase activity + +[Term] +id: GO:0033933 +name: branched-dextran exo-1,2-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,2-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115] +synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" EXACT [EC:3.2.1.115] +synonym: "dextran 1,2-alpha-glucosidase activity" EXACT [EC:3.2.1.115] +synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115] +xref: EC:3.2.1.115 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033934 +name: glucan 1,4-alpha-maltotriohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116] +synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" EXACT [EC:3.2.1.116] +synonym: "exo-maltotriohydrolase activity" EXACT [EC:3.2.1.116] +synonym: "maltotriohydrolase activity" EXACT [EC:3.2.1.116] +xref: EC:3.2.1.116 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033935 +name: oligoxyloglucan beta-glycosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120] +synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] +synonym: "oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120] +synonym: "oligoxyloglucan xyloglucohydrolase activity" EXACT [EC:3.2.1.120] +xref: EC:3.2.1.120 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033936 +name: polymannuronate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121] +synonym: "poly(mannuronide) mannuronohydrolase activity" EXACT [EC:3.2.1.121] +synonym: "polymannuronic acid polymerase activity" EXACT [EC:3.2.1.121] +xref: EC:3.2.1.121 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033937 +name: 3-deoxy-2-octulosonidase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124] +synonym: "2-keto-3-deoxyoctonate hydrolase activity" EXACT [EC:3.2.1.124] +synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" EXACT [EC:3.2.1.124] +synonym: "octulofuranosylono hydrolase activity" EXACT [EC:3.2.1.124] +synonym: "octulopyranosylonohydrolase activity" EXACT [EC:3.2.1.124] +synonym: "octulosylono hydrolase activity" EXACT [EC:3.2.1.124] +xref: EC:3.2.1.124 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033938 +name: 1,6-alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,6-linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127] +synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" EXACT [EC:3.2.1.127] +xref: EC:3.2.1.127 +is_a: GO:0004560 ! alpha-L-fucosidase activity + +[Term] +id: GO:0033939 +name: xylan alpha-1,2-glucuronosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131] +synonym: "1,2-alpha-glucuronidase activity" EXACT [EC:3.2.1.131] +synonym: "alpha-(1->2)-glucuronidase activity" EXACT [EC:3.2.1.131] +synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" EXACT [EC:3.2.1.131] +xref: EC:3.2.1.131 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033940 +name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136] +synonym: "endoarabinoxylanase activity" EXACT [EC:3.2.1.136] +synonym: "feraxan endoxylanase activity" EXACT [EC:3.2.1.136] +synonym: "feraxanase activity" EXACT [EC:3.2.1.136] +synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" EXACT [EC:3.2.1.136] +synonym: "glucuronoxylan xylanohydrolase activity" EXACT [EC:3.2.1.136] +synonym: "glucuronoxylan xylohydrolase activity" EXACT [EC:3.2.1.136] +synonym: "glucuronoxylanase activity" EXACT [EC:3.2.1.136] +xref: EC:3.2.1.136 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033941 +name: mannan exo-1,2-1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,2-alpha-D- and 1,6-alpha-D- linkages in yeast mannan, releasing D-mannose." [EC:3.2.1.137] +synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" EXACT [EC:3.2.1.137] +synonym: "exo-1,2-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.137] +xref: EC:3.2.1.137 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033942 +name: 4-alpha-D-\{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141] +synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141] +synonym: "malto-oligosyltrehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] +synonym: "maltooligosyl trehalose trehalohydrolase activity" EXACT [EC:3.2.1.141] +xref: EC:3.2.1.141 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033943 +name: galactan 1,3-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145] +synonym: "galactan (1->3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145] +xref: EC:3.2.1.145 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033944 +name: beta-galactofuranosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146] +synonym: "beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] +synonym: "beta-D-galactofuranoside hydrolase activity" EXACT [EC:3.2.1.146] +synonym: "exo-beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146] +synonym: "exo-beta-galactofuranosidase activity" EXACT [EC:3.2.1.146] +xref: EC:3.2.1.146 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033945 +name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-1,4-linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150] +synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" EXACT [EC:3.2.1.150] +synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" EXACT [EC:3.2.1.150] +xref: EC:3.2.1.150 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033946 +name: xyloglucan-specific endo-beta-1,4-glucanase activity +namespace: molecular_function +def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan)." [EC:3.2.1.151] +synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] +synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151] +synonym: "XEG" RELATED [EC:3.2.1.151] +synonym: "XH" RELATED [EC:3.2.1.151] +synonym: "xyloglucan endo-beta-1,4-glucanase activity" EXACT [EC:3.2.1.151] +synonym: "xyloglucanase activity" EXACT [EC:3.2.1.151] +synonym: "xyloglucanendohydrolase activity" EXACT [EC:3.2.1.151] +xref: EC:3.2.1.151 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033947 +name: mannosylglycoprotein endo-beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152] +synonym: "endo-beta-mannosidase activity" EXACT [EC:3.2.1.152] +xref: EC:3.2.1.152 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033948 +name: fructan beta-(2,1)-fructosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,1-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153] +synonym: "1-FEH II" RELATED [EC:3.2.1.153] +synonym: "1-FEH w1" RELATED [EC:3.2.1.153] +synonym: "1-FEH w2" RELATED [EC:3.2.1.153] +synonym: "1-fructan exohydrolase activity" EXACT [EC:3.2.1.153] +synonym: "beta-(2,1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] +synonym: "beta-(2-1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153] +synonym: "beta-(2-1)-linkage-specific fructan-beta-fructosidase activity" EXACT [EC:3.2.1.153] +synonym: "beta-(2-1)fructan exohydrolase activity" EXACT [EC:3.2.1.153] +xref: EC:3.2.1.153 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033949 +name: fructan beta-(2,6)-fructosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154] +synonym: "6-FEH" RELATED [EC:3.2.1.154] +synonym: "beta-(2,6)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.154] +synonym: "beta-(2-6)-fructan exohydrolase activity" EXACT [EC:3.2.1.154] +xref: EC:3.2.1.154 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033950 +name: xyloglucan-specific exo-beta-1,4-glucanase activity +namespace: molecular_function +def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan)." [EC:3.2.1.155] +synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" EXACT [EC:3.2.1.155] +synonym: "Cel74A" RELATED [EC:3.2.1.155] +xref: EC:3.2.1.155 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033951 +name: oligosaccharide reducing-end xylanase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156] +synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" EXACT [EC:3.2.1.156] +synonym: "reducing end xylose-releasing exo-oligoxylanase activity" EXACT [EC:3.2.1.156] +synonym: "Rex" RELATED [EC:3.2.1.156] +xref: EC:3.2.1.156 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033952 +name: iota-carrageenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157] +synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" EXACT [EC:3.2.1.157] +xref: EC:3.2.1.157 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033953 +name: alpha-agarase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158] +synonym: "agarase A33 activity" NARROW [EC:3.2.1.158] +synonym: "agarase activity" BROAD [EC:3.2.1.158] +synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158] +xref: EC:3.2.1.158 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033954 +name: alpha-neoagaro-oligosaccharide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159] +synonym: "alpha-NAOS hydrolase activity" EXACT [EC:3.2.1.159] +synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" EXACT [EC:3.2.1.159] +synonym: "alpha-neoagarooligosaccharide hydrolase activity" EXACT [EC:3.2.1.159] +xref: EC:3.2.1.159 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033955 +name: mitochondrial DNA inheritance +namespace: biological_process +def: "The process by which copies of the mitochondrial genome are segregated or distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah] +synonym: "mitochondrial chromosome segregation" RELATED [] +synonym: "mitochondrial DNA segregation" RELATED [] +is_a: GO:0000002 ! mitochondrial genome maintenance +relationship: part_of GO:0000001 ! mitochondrion inheritance + +[Term] +id: GO:0033956 +name: beta-apiosyl-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161] +synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" EXACT [EC:3.2.1.161] +synonym: "furcatin hydrolase activity" EXACT [EC:3.2.1.161] +synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" EXACT [EC:3.2.1.161] +synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" EXACT [EC:3.2.1.161] +xref: EC:3.2.1.161 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033957 +name: lambda-carrageenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162] +synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" EXACT [EC:3.2.1.162] +xref: EC:3.2.1.162 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033958 +name: DNA-deoxyinosine glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolyses DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15] +synonym: "deoxyribonucleic acid glycosylase activity" EXACT [EC:3.2.2.15] +synonym: "DNA(hypoxanthine) glycohydrolase activity" EXACT [EC:3.2.2.15] +synonym: "DNA-deoxyinosine deoxyribohydrolase activity" EXACT [EC:3.2.2.15] +synonym: "DNA-deoxyinosine glycosidase activity" EXACT [EC:3.2.2.15] +synonym: "hypoxanthine-DNA glycosylase activity" EXACT [EC:3.2.2.15] +xref: EC:3.2.2.15 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0033959 +name: deoxyribodipyrimidine endonucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cleaves the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17] +synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" EXACT [EC:3.2.2.17] +synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" EXACT [EC:3.2.2.17] +synonym: "endonuclease V activity" BROAD [EC:3.2.2.17] +synonym: "PD-DNA glycosylase activity" EXACT [EC:3.2.2.17] +synonym: "pyrimidine dimer DNA glycosylase activity" EXACT [EC:3.2.2.17] +synonym: "pyrimidine dimer DNA-glycosylase activity" EXACT [EC:3.2.2.17] +synonym: "T4-induced UV endonuclease activity" EXACT [EC:3.2.2.17] +xref: EC:3.2.2.17 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0033960 +name: N-methyl nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + D-ribose." [EC:3.2.2.25] +synonym: "7-methylxanthosine nucleosidase activity" EXACT [EC:3.2.2.25] +synonym: "7-methylxanthosine ribohydrolase activity" EXACT [EC:3.2.2.25] +synonym: "methylpurine nucleosidase activity" EXACT [EC:3.2.2.25] +synonym: "N-MeNase activity" EXACT [EC:3.2.2.25] +synonym: "N-methyl nucleoside hydrolase activity" EXACT [EC:3.2.2.25] +xref: EC:3.2.2.25 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0033961 +name: cis-stilbene-oxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] +synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] +synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] +synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] +synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] +synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9] +synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] +synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] +synonym: "mEH" RELATED [EC:3.3.2.9] +synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] +synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] +synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] +xref: EC:3.3.2.9 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0033962 +name: cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074] +synonym: "P body assembly" EXACT [] +synonym: "P body biogenesis" RELATED [] +synonym: "P-body assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:0033963 +name: cholesterol-5,6-oxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11] +synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" EXACT [EC:3.3.2.11] +synonym: "ChEH" RELATED [EC:3.3.2.11] +synonym: "cholesterol-epoxide hydrolase activity" EXACT [EC:3.3.2.11] +xref: EC:3.3.2.11 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0033964 +name: glycosphingolipid deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69] +synonym: "glycosphingolipid amidohydrolase activity" EXACT [EC:3.5.1.69] +synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69] +xref: EC:3.5.1.69 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033965 +name: aculeacin-A deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70] +synonym: "aculeacin A acylase activity" EXACT [EC:3.5.1.70] +synonym: "aculeacin-A amidohydrolase activity" EXACT [EC:3.5.1.70] +xref: EC:3.5.1.70 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033966 +name: N-substituted formamide deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91] +synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91] +synonym: "NfdA" RELATED [EC:3.5.1.91] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033967 +name: box C/D snoRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:mah] +is_a: GO:0016074 ! snoRNA metabolic process + +[Term] +id: GO:0033968 +name: glutaryl-7-aminocephalosporanic-acid acylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93] +synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" EXACT [EC:3.5.1.93] +synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] +synonym: "CA" RELATED [EC:3.5.1.93] +synonym: "cephalosporin acylase activity" EXACT [EC:3.5.1.93] +synonym: "cephalosporin C acylase activity" EXACT [EC:3.5.1.93] +synonym: "GA" RELATED [EC:3.5.1.93] +synonym: "GCA" RELATED [EC:3.5.1.93] +synonym: "GL-7-ACA acylase activity" EXACT [EC:3.5.1.93] +synonym: "glutaryl-7-ACA acylase activity" EXACT [EC:3.5.1.93] +synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" EXACT [EC:3.5.1.93] +xref: EC:3.5.1.93 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033969 +name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94] +synonym: "4-(glutamylamino)butanoate amidohydrolase activity" EXACT [EC:3.5.1.94] +synonym: "gamma-glutamyl-GABA hydrolase activity" EXACT [EC:3.5.1.94] +synonym: "PuuD" RELATED [EC:3.5.1.94] +synonym: "YcjL" RELATED [EC:3.5.1.94] +xref: EC:3.5.1.94 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033970 +name: N-malonylurea hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = malonate + urea." [EC:3.5.1.95] +synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" EXACT [EC:3.5.1.95] +synonym: "ureidomalonase activity" EXACT [EC:3.5.1.95] +xref: EC:3.5.1.95 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033971 +name: hydroxyisourate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate." [EC:3.5.2.17] +synonym: "5-hydroxyisourate amidohydrolase activity" EXACT [EC:3.5.2.17] +synonym: "5-hydroxyisourate hydrolase activity" EXACT [EC:3.5.2.17] +synonym: "HIUHase activity" EXACT [EC:3.5.2.17] +xref: EC:3.5.2.17 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0033972 +name: proclavaminate amidinohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea." [EC:3.5.3.22] +synonym: "PAH" RELATED [EC:3.5.3.22] +synonym: "proclavaminate amidino hydrolase activity" EXACT [EC:3.5.3.22] +synonym: "proclavaminic acid amidino hydrolase activity" EXACT [EC:3.5.3.22] +xref: EC:3.5.3.22 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0033973 +name: dCTP deaminase (dUMP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + 2 H2O = dUMP + diphosphate + NH3." [EC:3.5.4.30] +synonym: "dCTP aminohydrolase (dUMP-forming) activity" EXACT [EC:3.5.4.30] +xref: EC:3.5.4.30 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0033974 +name: nucleoside phosphoacylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolyses mixed phospho-anhydride bonds." [EC:3.6.1.24] +synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" EXACT [EC:3.6.1.24] +xref: EC:3.6.1.24 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0033975 +name: (R)-2-haloacid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9] +synonym: "(R)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.9] +synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9] +synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9] +synonym: "D-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.9] +synonym: "D-DEX" RELATED [EC:3.8.1.9] +xref: EC:3.8.1.9 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0033976 +name: 2-haloacid dehalogenase (configuration-inverting) activity +namespace: molecular_function +def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.10] +synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10] +synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.10] +synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" EXACT [EC:3.8.1.10] +synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.10] +synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" EXACT [EC:3.8.1.10] +synonym: "DL-DEXi" RELATED [EC:3.8.1.10] +xref: EC:3.8.1.10 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0033977 +name: 2-haloacid dehalogenase (configuration-retaining) activity +namespace: molecular_function +def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.11] +synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.11] +synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.11] +synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11] +synonym: "DL-DEXr" RELATED [EC:3.8.1.11] +xref: EC:3.8.1.11 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0033978 +name: phosphonopyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphonopyruvate + H2O = pyruvate + phosphate." [EC:3.11.1.3] +synonym: "PPH" RELATED [EC:3.11.1.3] +xref: EC:3.11.1.3 +is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds + +[Term] +id: GO:0033979 +name: box H/ACA snoRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:mah] +is_a: GO:0016074 ! snoRNA metabolic process + +[Term] +id: GO:0033980 +name: phosphonopyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2." [EC:4.1.1.82] +synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" EXACT [EC:4.1.1.82] +synonym: "3-phosphonopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.82] +xref: EC:4.1.1.82 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033981 +name: D-dopachrome decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-dopachrome = 5,6-dihydroxyindole + CO2." [EC:4.1.1.84] +synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" EXACT [EC:4.1.1.84] +synonym: "D-dopachrome carboxy-lyase activity" EXACT [EC:4.1.1.84] +synonym: "D-dopachrome tautomerase activity" EXACT [EC:4.1.1.84] +synonym: "D-tautomerase activity" EXACT [EC:4.1.1.84] +synonym: "phenylpyruvate tautomerase II activity" EXACT [EC:4.1.1.84] +xref: EC:4.1.1.84 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033982 +name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2." [EC:4.1.1.85] +synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" EXACT [EC:4.1.1.85] +synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.85] +synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" EXACT [EC:4.1.1.85] +synonym: "KGPDC" RELATED [EC:4.1.1.85] +synonym: "SgaH" RELATED [EC:4.1.1.85] +synonym: "SgbH" RELATED [EC:4.1.1.85] +synonym: "UlaD" RELATED [EC:4.1.1.85] +xref: EC:4.1.1.85 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033983 +name: diaminobutyrate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,4-diaminobutanoate = propane-1,3-diamine + CO2." [EC:4.1.1.86] +synonym: "DABA DC" RELATED [EC:4.1.1.86] +synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" EXACT [EC:4.1.1.86] +synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.86] +synonym: "L-2,4-diaminobutyrate decarboxylase activity" EXACT [EC:4.1.1.86] +xref: EC:4.1.1.86 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033984 +name: indole-3-glycerol-phosphate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8] +synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" EXACT [EC:4.1.2.8] +synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] +synonym: "BX1" RELATED [EC:4.1.2.8] +synonym: "IGL" RELATED [EC:4.1.2.8] +synonym: "indole glycerol phosphate hydrolase activity" EXACT [EC:4.1.2.8] +synonym: "indole synthase activity" EXACT [EC:4.1.2.8] +synonym: "indole-3-glycerol phosphate lyase activity" EXACT [EC:4.1.2.8] +synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8] +synonym: "indoleglycerolphosphate aldolase activity" EXACT [EC:4.1.2.8] +synonym: "tryptophan synthase alpha activity" EXACT [EC:4.1.2.8] +synonym: "TSA" RELATED [EC:4.1.2.8] +xref: EC:4.1.2.8 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0033985 +name: acidocalcisome lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0020022 ! acidocalcisome + +[Term] +id: GO:0033986 +name: response to methanol +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0033987 +name: 2-hydroxyisoflavanone dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105] +synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" EXACT [EC:4.2.1.105] +synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" EXACT [EC:4.2.1.105] +xref: EC:4.2.1.105 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033988 +name: bile-acid 7alpha-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate = 12alpha-hydroxy-3-oxochola-4,6-dienoate + H2O." [EC:4.2.1.106] +synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" EXACT [EC:4.2.1.106] +synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" EXACT [EC:4.2.1.106] +synonym: "BA7 alpha dehydratase activity" EXACT [EC:4.2.1.106] +xref: EC:4.2.1.106 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033989 +name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] +synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" EXACT [EC:4.2.1.107] +synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.107] +synonym: "46 kDa hydratase 2 activity" EXACT [EC:4.2.1.107] +synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107] +xref: EC:4.2.1.107 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033990 +name: ectoine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N4-acetyl-L-2,4-diaminobutanoate = L-ectoine + H2O." [EC:4.2.1.108] +synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] +synonym: "EctC" RELATED [EC:4.2.1.108] +synonym: "L-ectoine synthase activity" EXACT [EC:4.2.1.108] +synonym: "N-acetyldiaminobutanoate dehydratase activity" EXACT [EC:4.2.1.108] +synonym: "N-acetyldiaminobutyrate dehydratase activity" EXACT [EC:4.2.1.108] +synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108] +xref: EC:4.2.1.108 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033991 +name: aldos-2-ulose dehydratase activity +namespace: molecular_function +def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction), (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110] +synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" EXACT [EC:4.2.1.110] +synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" EXACT [EC:4.2.1.110] +synonym: "AUDH" RELATED [EC:4.2.1.110] +synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110] +xref: EC:4.2.1.110 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033992 +name: 1,5-anhydro-D-fructose dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111] +synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" EXACT [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" EXACT [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" EXACT [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose hydro-lyase activity" EXACT [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose hydrolyase activity" EXACT [EC:4.2.1.111] +synonym: "AF dehydratase activity" EXACT [EC:4.2.1.111] +synonym: "AFDH" RELATED [EC:4.2.1.111] +xref: EC:4.2.1.111 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033993 +name: response to lipid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0033994 +name: glucuronan lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: Eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14] +synonym: "(1,4)-beta-D-glucuronan lyase activity" EXACT [EC:4.2.2.14] +xref: EC:4.2.2.14 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033995 +name: anhydrosialidase activity +namespace: molecular_function +def: "Catalysis of the reaction: Elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15] +synonym: "anhydroneuraminidase activity" EXACT [EC:4.2.2.15] +synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] +synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15] +synonym: "sialidase L activity" EXACT [EC:4.2.2.15] +xref: EC:4.2.2.15 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033996 +name: levan fructotransferase (DFA-IV-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: Produces di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16] +synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" EXACT [EC:4.2.2.16] +synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" EXACT [EC:4.2.2.16] +synonym: "levan fructotransferase activity" EXACT [EC:4.2.2.16] +xref: EC:4.2.2.16 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033997 +name: inulin fructotransferase (DFA-I-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17] +synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" EXACT [EC:4.2.2.17] +synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" EXACT [EC:4.2.2.17] +synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" EXACT [EC:4.2.2.17] +synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" EXACT [EC:4.2.2.17] +synonym: "inulin fructotransferase (DFA-I-producing) activity" EXACT [EC:4.2.2.17] +xref: EC:4.2.2.17 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033998 +name: inulin fructotransferase (DFA-III-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18] +synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] +synonym: "inulase II activity" EXACT [EC:4.2.2.18] +synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] +synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" EXACT [EC:4.2.2.18] +synonym: "inulin fructotransferase (depolymerizing) activity" EXACT [EC:4.2.2.18] +synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18] +synonym: "inulin fructotransferase (DFA-III-producing) activity" EXACT [EC:4.2.2.18] +synonym: "inulinase II activity" EXACT [EC:4.2.2.18] +xref: EC:4.2.2.18 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033999 +name: chondroitin B lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: Eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S)." [EC:4.2.2.19] +synonym: "ChnB" RELATED [EC:4.2.2.19] +synonym: "chonB" RELATED [EC:4.2.2.19] +synonym: "chondroitinase B activity" EXACT [EC:4.2.2.19] +xref: EC:4.2.2.19 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0034000 +name: chondroitin-sulfate-ABC endolyase activity +namespace: molecular_function +def: "Catalysis of the reaction: Endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20] +synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20] +synonym: "chondroitin sulfate ABC endoeliminase activity" EXACT [EC:4.2.2.20] +synonym: "chondroitin sulfate ABC endolyase activity" EXACT [EC:4.2.2.20] +synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20] +synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20] +synonym: "chondroitinase activity" BROAD [EC:4.2.2.20] +synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20] +synonym: "ChS ABC lyase I activity" EXACT [EC:4.2.2.20] +xref: EC:4.2.2.20 +is_a: GO:0047486 ! chondroitin ABC lyase activity + +[Term] +id: GO:0034001 +name: chondroitin-sulfate-ABC exolyase activity +namespace: molecular_function +def: "Catalysis of the reaction: Exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21] +synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21] +synonym: "chondroitin sulfate ABC exoeliminase activity" EXACT [EC:4.2.2.21] +synonym: "chondroitin sulfate ABC exolyase activity" EXACT [EC:4.2.2.21] +synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21] +synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21] +synonym: "chondroitinase activity" BROAD [EC:4.2.2.21] +synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21] +synonym: "ChS ABC lyase II activity" EXACT [EC:4.2.2.21] +xref: EC:4.2.2.21 +is_a: GO:0047486 ! chondroitin ABC lyase activity + +[Term] +id: GO:0034002 +name: (R)-limonene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (+)-(4R)-limonene + diphosphate." [EC:4.2.3.20] +synonym: "(+)-limonene synthase activity" EXACT [EC:4.2.3.20] +synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" EXACT [EC:4.2.3.20] +synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" EXACT [EC:4.2.3.20] +xref: EC:4.2.3.20 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034003 +name: vetispiradiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = vetispiradiene + diphosphate." [EC:4.2.3.21] +synonym: "HVS" RELATED [EC:4.2.3.21] +synonym: "pemnaspirodiene synthase activity" EXACT [EC:4.2.3.21] +synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" EXACT [EC:4.2.3.21] +synonym: "vetispiradiene cyclase activity" EXACT [EC:4.2.3.21] +synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" EXACT [EC:4.2.3.21] +xref: EC:4.2.3.21 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034004 +name: germacradienol synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate and 2-trans,6-trans-farnesyl diphosphate = (-)-(7S)-germacrene D + diphosphate." [EC:4.2.3.22] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" EXACT [EC:4.2.3.22] +synonym: "germacradienol/germacrene-D synthase activity" EXACT [EC:4.2.3.22] +xref: EC:4.2.3.22 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034005 +name: germacrene-A synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23] +synonym: "(+)-(10R)-germacrene A synthase activity" EXACT [EC:4.2.3.23] +synonym: "(+)-germacrene A synthase activity" EXACT [EC:4.2.3.23] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" EXACT [EC:4.2.3.23] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" EXACT [EC:4.2.3.23] +synonym: "GAS" RELATED [EC:4.2.3.23] +synonym: "germacrene A synthase activity" EXACT [EC:4.2.3.23] +xref: EC:4.2.3.23 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034006 +name: amorpha-4,11-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" EXACT [EC:4.2.3.24] +synonym: "amorphadiene synthase activity" EXACT [EC:4.2.3.24] +xref: EC:4.2.3.24 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034007 +name: S-linalool synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + H2O = (3S)-linalool + diphosphate." [EC:4.2.3.25] +synonym: "3S-linalool synthase activity" EXACT [EC:4.2.3.25] +synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" EXACT [EC:4.2.3.25] +synonym: "LIS" RELATED [EC:4.2.3.25] +synonym: "Lis" RELATED [EC:4.2.3.25] +xref: EC:4.2.3.25 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034008 +name: R-linalool synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + H2O = (3R)-linalool + diphosphate." [EC:4.2.3.26] +synonym: "(-)-3R-linalool synthase activity" EXACT [EC:4.2.3.26] +synonym: "(3R)-linalool synthase activity" EXACT [EC:4.2.3.26] +synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" EXACT [EC:4.2.3.26] +xref: EC:4.2.3.26 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034009 +name: isoprene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate = isoprene + diphosphate." [EC:4.2.3.27] +synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" EXACT [EC:4.2.3.27] +synonym: "ISPC" RELATED [EC:4.2.3.27] +synonym: "ISPS" RELATED [EC:4.2.3.27] +xref: EC:4.2.3.27 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034010 +name: sulfolactate sulfo-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + bisulfite." [EC:4.4.1.24] +synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" EXACT [EC:4.4.1.24] +synonym: "3-sulfolactate bisulfite-lyase activity" EXACT [EC:4.4.1.24] +synonym: "Suy" RELATED [EC:4.4.1.24] +synonym: "SuyAB" RELATED [EC:4.4.1.24] +xref: EC:4.4.1.24 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0034011 +name: L-cysteate sulfo-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteate + H2O = pyruvate + bisulfite + NH3." [EC:4.4.1.25] +synonym: "CuyA" RELATED [EC:4.4.1.25] +synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" EXACT [EC:4.4.1.25] +synonym: "L-cysteate sulfo-lyase (deaminating) activity" EXACT [EC:4.4.1.25] +xref: EC:4.4.1.25 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0034012 +name: FAD-AMP lyase (cyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15] +synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15] +synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15] +synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15] +xref: EC:4.6.1.15 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0034013 +name: aliphatic aldoxime dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5] +synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" EXACT [EC:4.99.1.5] +synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5] +synonym: "OxdA" RELATED [EC:4.99.1.5] +xref: EC:4.99.1.5 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0034014 +name: response to triglyceride +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl] +synonym: "response to triacylglyceride" EXACT [] +synonym: "response to triacylglycerol" EXACT [] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0034015 +name: L-ribulose-5-phosphate 3-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22] +synonym: "L-xylulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.22] +synonym: "SgaU" RELATED [EC:5.1.3.22] +synonym: "UlaE" RELATED [EC:5.1.3.22] +xref: EC:5.1.3.22 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0034016 +name: polyenoic fatty acid isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,8E,14Z,17Z)-eicosapentaenoate." [EC:5.3.3.13] +synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" EXACT [EC:5.3.3.13] +synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] +synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13] +synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" EXACT [EC:5.3.3.13] +synonym: "PFI" RELATED [EC:5.3.3.13] +xref: EC:5.3.3.13 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0034017 +name: trans-2-decenoyl-acyl-carrier-protein isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-dec-2-enoyl-acyl-carrier-protein = cis-dec-3-enoyl-acyl-carrier-protein." [EC:5.3.3.14] +synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14] +synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" EXACT [EC:5.3.3.14] +synonym: "FabM" RELATED [EC:5.3.3.14] +synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] +synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] +synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14] +xref: EC:5.3.3.14 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0034018 +name: ascopyrone tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.3.15] +synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" EXACT [EC:5.3.3.15] +synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" EXACT [EC:5.3.3.15] +synonym: "APM tautomerase activity" EXACT [EC:5.3.3.15] +synonym: "APTM" RELATED [EC:5.3.3.15] +synonym: "ascopyrone intramolecular oxidoreductase activity" EXACT [EC:5.3.3.15] +synonym: "ascopyrone isomerase activity" EXACT [EC:5.3.3.15] +synonym: "ascopyrone P tautomerase activity" EXACT [EC:5.3.3.15] +xref: EC:5.3.3.15 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0034019 +name: capsanthin/capsorubin synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: violaxanthin = capsorubin and antheraxanthin = capsanthin." [EC:5.3.99.8] +synonym: "capsanthin-capsorubin synthase activity" EXACT [EC:5.3.99.8] +synonym: "CCS" RELATED [EC:5.3.99.8] +synonym: "ketoxanthophyll synthase activity" EXACT [EC:5.3.99.8] +synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8] +xref: EC:5.3.99.8 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034020 +name: neoxanthin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: violaxanthin = neoxanthin." [EC:5.3.99.9] +synonym: "NSY" RELATED [EC:5.3.99.9] +synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" EXACT [EC:5.3.99.9] +xref: EC:5.3.99.9 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034021 +name: response to silicon dioxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl] +synonym: "response to silica" EXACT [] +synonym: "response to silox" EXACT [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0034022 +name: 3-(hydroxyamino)phenol mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3] +synonym: "3-(hydroxyamino)phenol hydroxymutase activity" EXACT [EC:5.4.4.3] +synonym: "3-hydroxylaminophenol mutase activity" EXACT [EC:5.4.4.3] +synonym: "3HAP mutase activity" EXACT [EC:5.4.4.3] +xref: EC:5.4.4.3 +xref: UM-BBD_enzymeID:e0953 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0034023 +name: 5-(carboxyamino)imidazole ribonucleotide mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18] +synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" EXACT [EC:5.4.99.18] +synonym: "class I PurE" RELATED [EC:5.4.99.18] +synonym: "N5-CAIR mutase activity" EXACT [EC:5.4.99.18] +synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" EXACT [EC:5.4.99.18] +synonym: "PurE" RELATED [EC:5.4.99.18] +xref: EC:5.4.99.18 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0034024 +name: glutamate-putrescine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine." [EC:6.3.1.11] +synonym: "gamma-glutamylputrescine synthetase activity" EXACT [EC:6.3.1.11] +synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" EXACT [EC:6.3.1.11] +synonym: "YcjK" RELATED [EC:6.3.1.11] +xref: EC:6.3.1.11 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0034025 +name: D-aspartate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12] +synonym: "aslfm" RELATED [EC:6.3.1.12] +synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" EXACT [EC:6.3.1.12] +synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12] +synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12] +xref: EC:6.3.1.12 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0034026 +name: L-amino-acid alpha-ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.28] +synonym: "bacilysin synthetase activity" EXACT [EC:6.3.2.28] +synonym: "L-amino acid alpha-ligase activity" EXACT [EC:6.3.2.28] +synonym: "L-amino acid ligase activity" EXACT [EC:6.3.2.28] +synonym: "YwfE" RELATED [EC:6.3.2.28] +xref: EC:6.3.2.28 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0034027 +name: (carboxyethyl)arginine beta-lactam-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-N2-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate." [EC:6.3.3.4] +synonym: "beta-lactam synthetase activity" EXACT [EC:6.3.3.4] +synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] +synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4] +xref: EC:6.3.3.4 +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0034028 +name: 5-(carboxyamino)imidazole ribonucleotide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.4.18] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.18] +synonym: "N5-CAIR synthetase activity" EXACT [EC:6.3.4.18] +synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.4.18] +synonym: "PurK" RELATED [EC:6.3.4.18] +xref: EC:6.3.4.18 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0034029 +name: 2-oxoglutarate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate." [EC:6.4.1.7] +synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7] +synonym: "CFI" RELATED [EC:6.4.1.7] +synonym: "OGC" RELATED [EC:6.4.1.7] +synonym: "oxalosuccinate synthetase activity" EXACT [EC:6.4.1.7] +xref: EC:6.4.1.7 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0034030 +name: ribonucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "ribonucleoside bisphosphate anabolism" EXACT [] +synonym: "ribonucleoside bisphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside bisphosphate formation" EXACT [] +synonym: "ribonucleoside bisphosphate synthesis" EXACT [] +is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034031 +name: ribonucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "ribonucleoside bisphosphate breakdown" EXACT [] +synonym: "ribonucleoside bisphosphate catabolism" EXACT [] +synonym: "ribonucleoside bisphosphate degradation" EXACT [] +is_a: GO:0033869 ! nucleoside bisphosphate catabolic process +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034032 +name: purine nucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a glycosamine consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "purine nucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process + +[Term] +id: GO:0034033 +name: purine nucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a glycosamine consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "purine nucleoside bisphosphate anabolism" EXACT [] +synonym: "purine nucleoside bisphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside bisphosphate formation" EXACT [] +synonym: "purine nucleoside bisphosphate synthesis" EXACT [] +is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process + +[Term] +id: GO:0034034 +name: purine nucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a glycosamine consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "purine nucleoside bisphosphate breakdown" EXACT [] +synonym: "purine nucleoside bisphosphate catabolism" EXACT [] +synonym: "purine nucleoside bisphosphate degradation" EXACT [] +is_a: GO:0033869 ! nucleoside bisphosphate catabolic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process + +[Term] +id: GO:0034035 +name: purine ribonucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "purine ribonucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process + +[Term] +id: GO:0034036 +name: purine ribonucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "purine ribonucleoside bisphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside bisphosphate formation" EXACT [] +synonym: "purine ribonucleoside bisphosphate synthesis" EXACT [] +is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process +is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034037 +name: purine ribonucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd] +subset: gosubset_prok +synonym: "purine ribonucleoside bisphosphate breakdown" EXACT [] +synonym: "purine ribonucleoside bisphosphate catabolism" EXACT [] +synonym: "purine ribonucleoside bisphosphate degradation" EXACT [] +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034038 +name: deoxyhypusine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pd, MetaCyc:2.5.1.46-RXN] +comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase ; GO:0050983'. +synonym: "eIF-5A-deoxyhypusine synthase activity" EXACT [EC:2.5.1.46] +synonym: "eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] +synonym: "spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46] +xref: EC:2.5.1.46 +xref: MetaCyc:2.5.1.46-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0034039 +name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464] +synonym: "8-oxoG DNA N-glycosylase activity" EXACT [] +is_a: GO:0008534 ! oxidized purine base lesion DNA N-glycosylase activity + +[Term] +id: GO:0034040 +name: lipid-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:rl] +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0034041 +name: sterol-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:rl] +is_a: GO:0015248 ! sterol transporter activity +is_a: GO:0034040 ! lipid-transporting ATPase activity + +[Term] +id: GO:0034042 +name: 5-formyluracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] +synonym: "5-foU DNA N-glycosylase activity" EXACT [] +is_a: GO:0000703 ! oxidized pyrimidine base lesion DNA N-glycosylase activity + +[Term] +id: GO:0034043 +name: 5-hydroxymethyluracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] +synonym: "5-hmU DNA N-glycosylase activity" EXACT [] +is_a: GO:0000703 ! oxidized pyrimidine base lesion DNA N-glycosylase activity + +[Term] +id: GO:0034044 +name: exomer complex +namespace: cellular_component +def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877] +is_a: GO:0043234 ! protein complex +is_a: GO:0044431 ! Golgi apparatus part +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle + +[Term] +id: GO:0034045 +name: pre-autophagosomal structure membrane +namespace: cellular_component +def: "A cellular membrane associated with the pre-autophagosomal structure." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324] +synonym: "isolation membrane" RELATED [] +synonym: "PAS membrane" EXACT [] +is_a: GO:0016020 ! membrane +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0000407 ! pre-autophagosomal structure + +[Term] +id: GO:0034046 +name: poly(rG) binding +namespace: molecular_function +def: "Interacting selectively with a sequence of guanine residues in an RNA molecule." [GOC:mah] +synonym: "poly(G) binding" BROAD [] +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0034047 +name: regulation of protein phosphatase type 2A activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme protein phosphatase type 2A." [GOC:mah] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0034048 +name: negative regulation of protein phosphatase type 2A activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2A." [GOC:mah] +subset: gosubset_prok +synonym: "down regulation of protein phosphatase type 2A activity" EXACT [] +synonym: "down-regulation of protein phosphatase type 2A activity" EXACT [] +synonym: "downregulation of protein phosphatase type 2A activity" EXACT [] +synonym: "inhibition of protein phosphatase type 2A activity" NARROW [] +is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity +is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity + +[Term] +id: GO:0034049 +name: positive regulation of protein phosphatase type 2A activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2A." [GOC:mah] +subset: gosubset_prok +synonym: "activation of protein phosphatase type 2A activity" NARROW [] +synonym: "stimulation of protein phosphatase type 2A activity" NARROW [] +synonym: "up regulation of protein phosphatase type 2A activity" EXACT [] +synonym: "up-regulation of protein phosphatase type 2A activity" EXACT [] +synonym: "upregulation of protein phosphatase type 2A activity" EXACT [] +is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity +is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity + +[Term] +id: GO:0034050 +name: host programmed cell death induced by symbiont +namespace: biological_process +def: "Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules." [GOC:pamgo_curators] +comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'induction by symbiont of host programmed cell death ; GO:0052044'. +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0034051 +name: negative regulation of plant-type hypersensitive response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] +synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators] +synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators] +synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] +is_a: GO:0010363 ! regulation of plant-type hypersensitive response +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response + +[Term] +id: GO:0034052 +name: positive regulation of plant-type hypersensitive response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] +synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators] +synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators] +synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +is_a: GO:0010363 ! regulation of plant-type hypersensitive response +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0045089 ! positive regulation of innate immune response +relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response + +[Term] +id: GO:0034053 +name: modulation by symbiont of host defense-related programmed cell death +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'. +synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] +synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators] +synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] +synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death + +[Term] +id: GO:0034054 +name: negative regulation by symbiont of host defense-related programmed cell death +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'. +synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators] +synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators] +synonym: "inhibition of HR" NARROW [GOC:pamgo_curators] +synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "suppression by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "suppression of HR" NARROW [GOC:pamgo_curators] +is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death +is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death + +[Term] +id: GO:0034055 +name: positive regulation by symbiont of host defense-related programmed cell death +namespace: biological_process +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of plant-type hypersensitive response ; GO:0034052'. +synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "activation of HR" NARROW [GOC:pamgo_curators] +synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "enhancement by symbiont of host defense-related PCDprogrammed cell death" NARROW [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death + +[Term] +id: GO:0034056 +name: estrogen response element binding +namespace: molecular_function +def: "Interacting selectively with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005] +synonym: "ERE binding" EXACT [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0034057 +name: RNA strand-exchange activity +namespace: molecular_function +def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100] +is_a: GO:0003725 ! double-stranded RNA binding +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0034058 +name: endosomal vesicle fusion +namespace: biological_process +def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733] +synonym: "endosome vesicle fusion" EXACT [] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:0034059 +name: response to anoxia +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] +comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'. +synonym: "response to anoxic stress" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0034060 +name: cyanelle stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0034061 +name: DNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer." [EC:2.7.7.7, GOC:mah] +subset: gosubset_prok +synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7] +synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7] +synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7] +synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7] +synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0034062 +name: RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [EC:2.7.7.6, GOC:mah] +subset: gosubset_prok +synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] +synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] +synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] +synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6] +synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] +synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] +synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6] +synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6] +synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6] +synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] +synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6] +synonym: "transcriptase" BROAD [EC:2.7.7.6] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0034063 +name: stress granule assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:0034064 +name: Tor2-Mei2-Ste11 complex +namespace: cellular_component +def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0034065 +name: replication fork processing at rDNA locus +namespace: biological_process +def: "The process by which a DNA replication fork that has stalled at the rDNA replication fork barrier (RFB) is repaired and replication is restarted." [GOC:vw] +synonym: "recovery from replication fork arrest at rDNA locus" EXACT [] +synonym: "recovery from replication fork stalling at rDNA locus" EXACT [] +synonym: "replication fork processing at ribosomal DNA locus" EXACT [] +is_a: GO:0031297 ! replication fork processing +is_a: GO:0043007 ! maintenance of rDNA + +[Term] +id: GO:0034066 +name: Ric1p-Rgp1p complex +namespace: cellular_component +def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452] +is_a: GO:0043234 ! protein complex +is_a: GO:0044431 ! Golgi apparatus part + +[Term] +id: GO:0034067 +name: protein localization in Golgi apparatus +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] +is_a: GO:0033365 ! protein localization in organelle + +[Term] +id: GO:0034068 +name: aminoglycoside nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb] +subset: gosubset_prok +synonym: "aminoglycoside adenylyltransferase activity" NARROW [] +synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0034069 +name: aminoglycoside N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb] +subset: gosubset_prok +synonym: "kanamycin acetyltransferase activity" NARROW [] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0034070 +name: aminoglycoside 1-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb] +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0034071 +name: aminoglycoside phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah] +subset: gosubset_prok +synonym: "aminoglycoside kinase activity" EXACT [] +xref: EC:2.7.1.119 +xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0034072 +name: squalene cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0034073 +name: tetrahymanol cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: squalene = tetrahymanol." [ChEBI:9493, GOC:cb, PMID:18033581] +is_a: GO:0034072 ! squalene cyclase activity + +[Term] +id: GO:0034074 +name: marneral synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581] +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0034075 +name: arabidiol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidosqualene + H2O= arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751] +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0034076 +name: cucurbitadienol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581, UniProtKB:Q6BE24] +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0034077 +name: butanediol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY] +subset: gosubset_prok +synonym: "butanediol metabolism" EXACT [] +synonym: "butylene glycol metabolic process" EXACT [] +synonym: "butylene glycol metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:0034078 +name: butanediol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] +subset: gosubset_prok +synonym: "butanediol breakdown" EXACT [] +synonym: "butanediol catabolism" EXACT [] +synonym: "butanediol degradation" EXACT [] +synonym: "butanediol utilization" RELATED [] +synonym: "butylene glycol catabolic process" EXACT [] +synonym: "butylene glycol catabolism" EXACT [] +is_a: GO:0034077 ! butanediol metabolic process +is_a: GO:0034313 ! diol catabolic process + +[Term] +id: GO:0034079 +name: butanediol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] +subset: gosubset_prok +synonym: "butanediol anabolism" EXACT [] +synonym: "butanediol biosynthesis" EXACT [] +synonym: "butanediol formation" EXACT [] +synonym: "butanediol synthesis" EXACT [] +synonym: "butylene glycol biosynthesis" EXACT [] +synonym: "butylene glycol biosynthetic process" EXACT [] +xref: MetaCyc:P125-PWY +is_a: GO:0034077 ! butanediol metabolic process +is_a: GO:0034312 ! diol biosynthetic process + +[Term] +id: GO:0034080 +name: DNA replication-independent nucleosome assembly at centromere +namespace: biological_process +def: "The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin; occurs outside the context of DNA replication." [GOC:mah, PMID:18158900] +synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [] +is_a: GO:0006336 ! DNA replication-independent nucleosome assembly +is_a: GO:0031055 ! chromatin remodeling at centromere + +[Term] +id: GO:0034081 +name: polyketide synthase complex +namespace: cellular_component +def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085] +synonym: "PKS" RELATED [] +synonym: "PKS complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034082 +name: type II polyketide synthase complex +namespace: cellular_component +def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085] +synonym: "type II PKS" EXACT [] +synonym: "type II PKS complex" EXACT [] +synonym: "type II polyketide synthase" EXACT [] +is_a: GO:0034081 ! polyketide synthase complex + +[Term] +id: GO:0034083 +name: type III polyketide synthase complex +namespace: cellular_component +def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085] +synonym: "type III PKS" EXACT [] +synonym: "type III PKS complex" EXACT [] +synonym: "type III polyketide synthase" EXACT [] +is_a: GO:0034081 ! polyketide synthase complex + +[Term] +id: GO:0034084 +name: steryl deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159] +synonym: "sterol deacetylase activity" EXACT [] +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0034085 +name: establishment of sister chromatid cohesion +namespace: biological_process +def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase." [GOC:mah, PMID:14623866] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0034086 +name: maintenance of sister chromatid cohesion +namespace: biological_process +def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0034087 +name: establishment of mitotic sister chromatid cohesion +namespace: biological_process +def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah] +is_a: GO:0034085 ! establishment of sister chromatid cohesion +relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion + +[Term] +id: GO:0034088 +name: maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] +synonym: "mitotic cohesion stability" RELATED [] +is_a: GO:0034086 ! maintenance of sister chromatid cohesion +relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion + +[Term] +id: GO:0034089 +name: establishment of meiotic sister chromatid cohesion +namespace: biological_process +def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah] +is_a: GO:0034085 ! establishment of sister chromatid cohesion +relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0034090 +name: maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah] +is_a: GO:0034086 ! maintenance of sister chromatid cohesion +relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0034091 +name: regulation of maintenance of sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion + +[Term] +id: GO:0034092 +name: negative regulation of maintenance of sister chromatid cohesion +namespace: biological_process +def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +is_a: GO:0045875 ! negative regulation of sister chromatid cohesion +relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion + +[Term] +id: GO:0034093 +name: positive regulation of maintenance of sister chromatid cohesion +namespace: biological_process +def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +is_a: GO:0045876 ! positive regulation of sister chromatid cohesion +relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion + +[Term] +id: GO:0034094 +name: regulation of maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +is_a: GO:0040020 ! regulation of meiosis +relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion + +[Term] +id: GO:0034095 +name: negative regulation of maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion +is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion +relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion + +[Term] +id: GO:0034096 +name: positive regulation of maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion +is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion +relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion + +[Term] +id: GO:0034097 +name: response to cytokine stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0034098 +name: Cdc48p-Npl4p-Ufd1p AAA ATPase complex +namespace: cellular_component +def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins." [PMID:11813000, PMID:16179952] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0034099 +name: luminal surveillance complex +namespace: cellular_component +def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065] +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005788 ! endoplasmic reticulum lumen + +[Term] +id: GO:0034100 +name: L-vinylglycine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-vinylglutamate + H2O = alpha-ketobutryrate + NH3." [GOC:ecd, PMID:11470512] +comment: Note that this function was formerly EC:4.1.99.4. +subset: gosubset_prok +synonym: "L-VG deaminase activity" EXACT [EC:3.5.99.7] +xref: EC:3.5.99.7 +xref: MetaCyc:4.1.99.4-RXN +xref: UM-BBD_enzymeID:e0274 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0034101 +name: erythrocyte homeostasis +namespace: biological_process +def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0034102 +name: erythrocyte clearance +namespace: biological_process +def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397] +comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont. +synonym: "neocytolysis" NARROW [PMID:14754397] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0034101 ! erythrocyte homeostasis + +[Term] +id: GO:0034103 +name: regulation of tissue remodeling +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048771 ! tissue remodeling + +[Term] +id: GO:0034104 +name: negative regulation of tissue remodeling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add] +is_a: GO:0034103 ! regulation of tissue remodeling +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0048771 ! tissue remodeling + +[Term] +id: GO:0034105 +name: positive regulation of tissue remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add] +is_a: GO:0034103 ! regulation of tissue remodeling +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0048771 ! tissue remodeling + +[Term] +id: GO:0034106 +name: regulation of erythrocyte clearance +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] +synonym: "regulation of neocytolysis" NARROW [PMID:14754397] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0034102 ! erythrocyte clearance + +[Term] +id: GO:0034107 +name: negative regulation of erythrocyte clearance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] +synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:0034106 ! regulation of erythrocyte clearance +relationship: negatively_regulates GO:0034102 ! erythrocyte clearance + +[Term] +id: GO:0034108 +name: positive regulation of erythrocyte clearance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] +synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:0034106 ! regulation of erythrocyte clearance +relationship: positively_regulates GO:0034102 ! erythrocyte clearance + +[Term] +id: GO:0034109 +name: homotypic cell-cell adhesion +namespace: biological_process +def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] +comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms. +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0034110 +name: regulation of homotypic cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034111 +name: negative regulation of homotypic cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034112 +name: positive regulation of homotypic cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034113 +name: heterotypic cell-cell adhesion +namespace: biological_process +def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add] +comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms. +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0034114 +name: regulation of heterotypic cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0034115 +name: negative regulation of heterotypic cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion +relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0034116 +name: positive regulation of heterotypic cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion +relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0034117 +name: erythrocyte aggregation +namespace: biological_process +def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543] +is_a: GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034118 +name: regulation of erythrocyte aggregation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0034119 +name: negative regulation of erythrocyte aggregation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] +is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion +is_a: GO:0034118 ! regulation of erythrocyte aggregation +relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0034120 +name: positive regulation of erythrocyte aggregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] +is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion +is_a: GO:0034118 ! regulation of erythrocyte aggregation +relationship: positively_regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0034121 +name: regulation of toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034122 +name: negative regulation of toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034123 +name: positive regulation of toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034124 +name: regulation of MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT [] +synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0034125 +name: negative regulation of MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT [] +synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway +relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0034126 +name: positive regulation of MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT [] +synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway +relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0034127 +name: regulation of MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT [] +synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0034128 +name: negative regulation of MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT [] +synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway +relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0034129 +name: positive regulation of MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT [] +synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway +relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0034130 +name: toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR1 signaling pathway" EXACT [] +synonym: "toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034131 +name: regulation of toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR1 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway + +[Term] +id: GO:0034132 +name: negative regulation of toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR1 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway +relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway + +[Term] +id: GO:0034133 +name: positive regulation of toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR1 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway +relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway + +[Term] +id: GO:0034134 +name: toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR2 signaling pathway" EXACT [] +synonym: "toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034135 +name: regulation of toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR2 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0034136 +name: negative regulation of toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR2 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway +relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0034137 +name: positive regulation of toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR2 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway +relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0034138 +name: toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR3 signaling pathway" EXACT [] +synonym: "toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034139 +name: regulation of toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR3 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway + +[Term] +id: GO:0034140 +name: negative regulation of toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR3 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway +relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway + +[Term] +id: GO:0034141 +name: positive regulation of toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR3 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway +relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway + +[Term] +id: GO:0034142 +name: toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR4 signaling pathway" EXACT [] +synonym: "toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034143 +name: regulation of toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR4 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0034144 +name: negative regulation of toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR4 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway +relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0034145 +name: positive regulation of toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR4 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway +relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0034146 +name: toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR5 signaling pathway" EXACT [] +synonym: "toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034147 +name: regulation of toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR5 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway + +[Term] +id: GO:0034148 +name: negative regulation of toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR5 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway +relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway + +[Term] +id: GO:0034149 +name: positive regulation of toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR5 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway +relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway + +[Term] +id: GO:0034150 +name: toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR6 signaling pathway" EXACT [] +synonym: "toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034151 +name: regulation of toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR6 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway + +[Term] +id: GO:0034152 +name: negative regulation of toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR6 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway +relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway + +[Term] +id: GO:0034153 +name: positive regulation of toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR6 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway +relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway + +[Term] +id: GO:0034154 +name: toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR7 signaling pathway" EXACT [] +synonym: "toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034155 +name: regulation of toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR7 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway + +[Term] +id: GO:0034156 +name: negative regulation of toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR7 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway +relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway + +[Term] +id: GO:0034157 +name: positive regulation of toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR7 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway +relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway + +[Term] +id: GO:0034158 +name: toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR8 signaling pathway" EXACT [] +synonym: "toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034159 +name: regulation of toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR8 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway + +[Term] +id: GO:0034160 +name: negative regulation of toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR8 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway +relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway + +[Term] +id: GO:0034161 +name: positive regulation of toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR8 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway +relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway + +[Term] +id: GO:0034162 +name: toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR9 signaling pathway" EXACT [] +synonym: "toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034163 +name: regulation of toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR9 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway + +[Term] +id: GO:0034164 +name: negative regulation of toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR9 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway +relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway + +[Term] +id: GO:0034165 +name: positive regulation of toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR9 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway +relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway + +[Term] +id: GO:0034166 +name: toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR10 signaling pathway" EXACT [] +synonym: "toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034167 +name: regulation of toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR10 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway + +[Term] +id: GO:0034168 +name: negative regulation of toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR10 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway +relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway + +[Term] +id: GO:0034169 +name: positive regulation of toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR10 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway +relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway + +[Term] +id: GO:0034170 +name: toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR11 signaling pathway" EXACT [] +synonym: "toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034171 +name: regulation of toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR11 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway + +[Term] +id: GO:0034172 +name: negative regulation of toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR11 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway +relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway + +[Term] +id: GO:0034173 +name: positive regulation of toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR11 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway +relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway + +[Term] +id: GO:0034174 +name: toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR12 signaling pathway" EXACT [] +synonym: "toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034175 +name: regulation of toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR12 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway + +[Term] +id: GO:0034176 +name: negative regulation of toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR12 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway +relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway + +[Term] +id: GO:0034177 +name: positive regulation of toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR12 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway +relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway + +[Term] +id: GO:0034178 +name: toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR13 signaling pathway" EXACT [] +synonym: "toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034179 +name: regulation of toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR13 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway + +[Term] +id: GO:0034180 +name: negative regulation of toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR13 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway +relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway + +[Term] +id: GO:0034181 +name: positive regulation of toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR13 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway +relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway + +[Term] +id: GO:0034182 +name: regulation of maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion + +[Term] +id: GO:0034183 +name: negative regulation of maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion + +[Term] +id: GO:0034184 +name: positive regulation of maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion + +[Term] +id: GO:0034185 +name: apolipoprotein binding +namespace: molecular_function +def: "Interacting selectively with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:rl] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0034186 +name: apolipoprotein A-I binding +namespace: molecular_function +def: "Interacting selectively with apolipoprotein A-I." [GOC:rl] +is_a: GO:0034185 ! apolipoprotein binding + +[Term] +id: GO:0034187 +name: apolipoprotein E binding +namespace: molecular_function +def: "Interacting selectively with apolipoprotein E." [GOC:rl] +is_a: GO:0034185 ! apolipoprotein binding + +[Term] +id: GO:0034188 +name: apolipoprotein A-I receptor activity +namespace: molecular_function +def: "Combining with apolipoprotein A-I to initiate a change in cell activity." [GOC:rl] +is_a: GO:0030226 ! apolipoprotein receptor activity +is_a: GO:0034186 ! apolipoprotein A-I binding + +[Term] +id: GO:0034189 +name: very-low-density lipoprotein binding +namespace: molecular_function +def: "Interacting selectively with very-low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals." [GOC:mah] +subset: gosubset_prok +synonym: "VLDL binding" EXACT [] +is_a: GO:0008034 ! lipoprotein binding + +[Term] +id: GO:0034190 +name: apolipoprotein receptor binding +namespace: molecular_function +def: "Interacting selectively with an apolipoprotein receptor." [GOC:rl] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0034191 +name: apolipoprotein A-I receptor binding +namespace: molecular_function +def: "Interacting selectively with an apolipoprotein A-I receptor." [GOC:rl] +is_a: GO:0034190 ! apolipoprotein receptor binding + +[Term] +id: GO:0034192 +name: D-galactonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah] +subset: gosubset_prok +synonym: "D-galactonate metabolism" EXACT [] +is_a: GO:0019583 ! galactonate metabolic process + +[Term] +id: GO:0034193 +name: L-galactonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah] +subset: gosubset_prok +synonym: "L-galactonate metabolism" EXACT [] +is_a: GO:0019583 ! galactonate metabolic process + +[Term] +id: GO:0034194 +name: D-galactonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah] +subset: gosubset_prok +synonym: "D-galactonate breakdown" EXACT [] +synonym: "D-galactonate catabolism" EXACT [] +synonym: "D-galactonate degradation" EXACT [] +xref: MetaCyc:GALACTCAT-PWY +is_a: GO:0019584 ! galactonate catabolic process +is_a: GO:0034192 ! D-galactonate metabolic process + +[Term] +id: GO:0034195 +name: L-galactonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah] +subset: gosubset_prok +synonym: "L-galactonate breakdown" EXACT [] +synonym: "L-galactonate catabolism" EXACT [] +synonym: "L-galactonate degradation" EXACT [] +xref: MetaCyc:GALACTCAT-PWY +is_a: GO:0019584 ! galactonate catabolic process +is_a: GO:0034193 ! L-galactonate metabolic process + +[Term] +id: GO:0034196 +name: acylglycerol transport +namespace: biological_process +def: "The directed movement of an acylglycerol into, out of, within or between cells. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:rl] +synonym: "glyceride transport" EXACT [] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0034197 +name: triacylglycerol transport +namespace: biological_process +def: "The directed movement of triacylglycerol into, out of, within or between cells. Triacylglycerols are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:rl] +synonym: "triglyceride transport" EXACT [] +is_a: GO:0034196 ! acylglycerol transport + +[Term] +id: GO:0034198 +name: cellular response to amino acid starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0034199 +name: activation of protein kinase A activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pd] +synonym: "protein kinase A activation" EXACT [] +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:0034200 +name: D-heptose 1,7-bisphosphate phosphatase +namespace: molecular_function +def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237] +xref: MetaCyc:RXN0-4361 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0034201 +name: response to oleate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a oleate stimulus." [ChEBI:30823, GOC:rb, PMID:17551510] +synonym: "response to oleic acid" EXACT [] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0034202 +name: glycolipid-translocating activity +namespace: molecular_function +def: "Catalysis of the movement of glycolipids from one membrane face to the other ('flippase' activity)." [GOC:krc, PMID:11807558] +synonym: "flippase activity" BROAD [] +is_a: GO:0017089 ! glycolipid transporter activity + +[Term] +id: GO:0034203 +name: glycolipid translocation +namespace: biological_process +def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558] +subset: gosubset_prok +synonym: "flippase" RELATED [] +synonym: "scramblase" RELATED [] +is_a: GO:0016044 ! membrane organization +is_a: GO:0034204 ! lipid translocation +is_a: GO:0046836 ! glycolipid transport + +[Term] +id: GO:0034204 +name: lipid translocation +namespace: biological_process +def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0034205 +name: beta-amyloid formation +namespace: biological_process +def: "The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP)." [GOC:mah] +comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because beta-amyloid can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. +is_a: GO:0042987 ! amyloid precursor protein catabolic process +is_a: GO:0050435 ! beta-amyloid metabolic process + +[Term] +id: GO:0034206 +name: enhanceosome +namespace: cellular_component +def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0034207 +name: steroid acetylation +namespace: biological_process +def: "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034208 +name: steroid deacetylation +namespace: biological_process +def: "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034209 +name: sterol acetylation +namespace: biological_process +def: "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] +is_a: GO:0034207 ! steroid acetylation + +[Term] +id: GO:0034210 +name: sterol deacetylation +namespace: biological_process +def: "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] +is_a: GO:0034208 ! steroid deacetylation + +[Term] +id: GO:0034211 +name: GTP-dependent protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP." [GOC:ecd, PMID:17200152] +xref: EC:2.7.11.- +xref: Reactome:13522 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0034212 +name: peptide N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah] +subset: gosubset_prok +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0034213 +name: quinolinate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah] +synonym: "quinolinate breakdown" EXACT [] +synonym: "quinolinate catabolism" EXACT [] +synonym: "quinolinate degradation" EXACT [] +is_a: GO:0046874 ! quinolinate metabolic process + +[Term] +id: GO:0034214 +name: protein hexamerization +namespace: biological_process +def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd] +subset: gosubset_prok +synonym: "protein hexamer assembly" EXACT [] +synonym: "protein hexamer biosynthesis" EXACT [] +synonym: "protein hexamer biosynthetic process" EXACT [] +synonym: "protein hexamer formation" EXACT [] +is_a: GO:0051259 ! protein oligomerization + +[Term] +id: GO:0034215 +name: thiamin:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamin(out) + H+(out) = thiamin(in) + H+(in)." [GOC:mah] +synonym: "thiamin:proton symporter activity" EXACT [] +synonym: "thiamine:hydrogen symporter activity" EXACT [] +synonym: "thiamine:proton symporter activity" EXACT [] +is_a: GO:0015295 ! solute:hydrogen symporter activity +is_a: GO:0015403 ! thiamin uptake transmembrane transporter activity + +[Term] +id: GO:0034216 +name: high-affinity thiamin:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamin(out) + H+(out) = thiamin(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +synonym: "high affinity thiamin:hydrogen symporter activity" EXACT [] +synonym: "high-affinity thiamin:proton symporter activity" EXACT [] +synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT [] +synonym: "high-affinity thiamine:proton symporter activity" EXACT [] +is_a: GO:0034215 ! thiamin:hydrogen symporter activity + +[Term] +id: GO:0034217 +name: ascospore wall chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall chitin anabolism" EXACT [] +synonym: "ascospore wall chitin biosynthesis" EXACT [] +synonym: "ascospore wall chitin formation" EXACT [] +synonym: "ascospore wall chitin synthesis" EXACT [] +is_a: GO:0006038 ! cell wall chitin biosynthetic process +is_a: GO:0034218 ! ascospore wall chitin metabolic process +relationship: part_of GO:0030476 ! ascospore wall assembly + +[Term] +id: GO:0034218 +name: ascospore wall chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall chitin metabolism" EXACT [] +is_a: GO:0006037 ! cell wall chitin metabolic process + +[Term] +id: GO:0034219 +name: transmembrane carbohydrate transport +namespace: biological_process +def: "The process whereby a carbohydrate is transported from one side of a membrane to the other." [GOC:mah] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034220 +name: transmembrane ion transport +namespace: biological_process +def: "A process whereby an ion is transported from one side of a membrane to the other." [GOC:mah] +is_a: GO:0006811 ! ion transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034221 +name: fungal-type cell wall chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of vegetatively growing fungal cells." [GOC:mah] +synonym: "fungal-type cell wall chitin anabolism" EXACT [] +synonym: "fungal-type cell wall chitin biosynthesis" EXACT [] +synonym: "fungal-type cell wall chitin formation" EXACT [] +synonym: "fungal-type cell wall chitin synthesis" EXACT [] +is_a: GO:0006038 ! cell wall chitin biosynthetic process +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0034222 +name: regulation of cell wall chitin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah] +synonym: "regulation of cell wall chitin metabolism" EXACT [] +is_a: GO:0032882 ! regulation of chitin metabolic process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006037 ! cell wall chitin metabolic process + +[Term] +id: GO:0034223 +name: regulation of ascospore wall chitin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah] +synonym: "regulation of ascospore wall chitin anabolism" EXACT [] +synonym: "regulation of ascospore wall chitin biosynthesis" EXACT [] +synonym: "regulation of ascospore wall chitin formation" EXACT [] +synonym: "regulation of ascospore wall chitin synthesis" EXACT [] +is_a: GO:0032884 ! regulation of cell wall chitin biosynthetic process +is_a: GO:0034307 ! regulation of ascospore formation +relationship: regulates GO:0034217 ! ascospore wall chitin biosynthetic process + +[Term] +id: GO:0034224 +name: cellular response to zinc ion starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah] +synonym: "ellular response to zinc ion limitation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0034225 +name: regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah] +synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT [] +is_a: GO:0034224 ! cellular response to zinc ion starvation +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0034226 +name: lysine import +namespace: biological_process +def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:jl, GOC:mah] +synonym: "L-lysine import" NARROW [] +synonym: "lysine uptake" EXACT [] +is_a: GO:0015819 ! lysine transport +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0034227 +name: tRNA thio-modification +namespace: biological_process +def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066] +subset: gosubset_prok +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0034228 +name: ethanolamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ethanolamine from one side of the membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] +subset: gosubset_prok +synonym: "2-aminoethanol transmembrane transporter activity" EXACT [] +synonym: "ethanolamine permease activity" EXACT [] +synonym: "monoethanolamine transmembrane transporter activity" EXACT [] +is_a: GO:0005275 ! amine transmembrane transporter activity + +[Term] +id: GO:0034229 +name: ethanolamine transport +namespace: biological_process +def: "The directed movement of ethanolamine into, out of, within or between cells. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] +synonym: "2-aminoethanol transport" EXACT [] +synonym: "monoethanolamine transport" EXACT [] +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0034230 +name: enkephalin processing +namespace: biological_process +def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:mah, GOC:rl, PMID:8262946] +synonym: "enkephalin formation" EXACT [] +synonym: "peptide enkephalin formation" EXACT [] +synonym: "peptide enkephalin processing" EXACT [] +is_a: GO:0016486 ! peptide hormone processing +is_a: GO:0051605 ! protein maturation via proteolysis + +[Term] +id: GO:0034231 +name: islet amyloid polypeptide processing +namespace: biological_process +def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:rl, PMID:15983213, PMID:8262946] +synonym: "IAPP formation" EXACT [] +synonym: "IAPP processing" EXACT [] +synonym: "islet amyloid peptide formation" EXACT [] +synonym: "islet amyloid peptide processing" EXACT [] +synonym: "islet amyloid polypeptide formation" RELATED [] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0034232 +name: ascospore wall chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall chitin breakdown" EXACT [] +synonym: "ascospore wall chitin catabolism" EXACT [] +synonym: "ascospore wall chitin degradation" EXACT [] +is_a: GO:0006039 ! cell wall chitin catabolic process +is_a: GO:0034218 ! ascospore wall chitin metabolic process + +[Term] +id: GO:0034233 +name: regulation of cell wall chitin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah] +synonym: "regulation of cell wall chitin breakdown" EXACT [] +synonym: "regulation of cell wall chitin catabolism" EXACT [] +synonym: "regulation of cell wall chitin degradation" EXACT [] +is_a: GO:0034222 ! regulation of cell wall chitin metabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0006039 ! cell wall chitin catabolic process + +[Term] +id: GO:0034234 +name: regulation of ascospore wall chitin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah] +synonym: "regulation of ascospore wall chitin breakdown" EXACT [] +synonym: "regulation of ascospore wall chitin catabolism" EXACT [] +synonym: "regulation of ascospore wall chitin degradation" EXACT [] +is_a: GO:0034233 ! regulation of cell wall chitin catabolic process +relationship: regulates GO:0034232 ! ascospore wall chitin catabolic process + +[Term] +id: GO:0034235 +name: GPI anchor binding +namespace: molecular_function +def: "Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] +comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached. +synonym: "glycosylphosphatidylinositol binding" EXACT [] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0034236 +name: protein kinase A catalytic subunit binding +namespace: molecular_function +def: "Interacting selectively with one or both of the catalytic subunits of protein kinase A." [GOC:mah] +synonym: "PKA catalytic subunit binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding +is_a: GO:0051018 ! protein kinase A binding + +[Term] +id: GO:0034237 +name: protein kinase A regulatory subunit binding +namespace: molecular_function +def: "Interacting selectively with one or both of the regulatory subunits of protein kinase A." [GOC:mah] +synonym: "PKA regulatory subunit binding" EXACT [] +synonym: "protein kinase A anchoring activity" RELATED [] +is_a: GO:0051018 ! protein kinase A binding + +[Term] +id: GO:0034238 +name: macrophage fusion +namespace: biological_process +def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl] +is_a: GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0034239 +name: regulation of macrophage fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah] +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: regulates GO:0034238 ! macrophage fusion + +[Term] +id: GO:0034240 +name: negative regulation of macrophage fusion +namespace: biological_process +def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah] +is_a: GO:0034239 ! regulation of macrophage fusion +is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion +relationship: negatively_regulates GO:0034238 ! macrophage fusion + +[Term] +id: GO:0034241 +name: positive regulation of macrophage fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah] +is_a: GO:0034239 ! regulation of macrophage fusion +is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion +relationship: positively_regulates GO:0034238 ! macrophage fusion + +[Term] +id: GO:0034242 +name: negative regulation of syncytium formation by plasma membrane fusion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0034243 +name: regulation of RNA elongation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah] +synonym: "regulation of transcription elongation from RNA polymerase II promoter" BROAD [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0032784 ! regulation of RNA elongation +relationship: regulates GO:0006368 ! RNA elongation from RNA polymerase II promoter + +[Term] +id: GO:0034244 +name: negative regulation of RNA elongation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah] +synonym: "negative regulation of transcription elongation from RNA polymerase II promoter" BROAD [] +is_a: GO:0032785 ! negative regulation of RNA elongation +is_a: GO:0034243 ! regulation of RNA elongation from RNA polymerase II promoter +relationship: negatively_regulates GO:0006368 ! RNA elongation from RNA polymerase II promoter + +[Term] +id: GO:0034245 +name: mitochondrial DNA-directed RNA polymerase complex +namespace: cellular_component +def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382] +synonym: "mitochondrial RNA polymerase complex" BROAD [] +synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT [] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +is_a: GO:0044429 ! mitochondrial part + +[Term] +id: GO:0034246 +name: mitochondrial transcription initiation factor activity +namespace: molecular_function +def: "A transcription factor activity that confers promoter specificity upon mitochondrial RNA polymerase, in a manner analogous to eubacterial sigma factors." [GOC:mah] +synonym: "mitochondrial polymerase transcription factor activity" EXACT [] +synonym: "mitochondrial transcription factor activity" RELATED [] +is_a: GO:0016986 ! transcription initiation factor activity + +[Term] +id: GO:0034247 +name: snoRNA splicing +namespace: biological_process +def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah] +is_a: GO:0008380 ! RNA splicing +is_a: GO:0043144 ! snoRNA processing + +[Term] +id: GO:0034248 +name: regulation of amide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] +synonym: "regulation of amide metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0034249 +name: negative regulation of amide metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] +synonym: "negative regulation of amide metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0034248 ! regulation of amide metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0034250 +name: positive regulation of amide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] +synonym: "positive regulation of amide metabolism" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0034248 ! regulation of amide metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0034251 +name: regulation of amide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] +synonym: "regulation of amide breakdown" EXACT [] +synonym: "regulation of amide catabolism" EXACT [] +synonym: "regulation of amide degradation" EXACT [] +is_a: GO:0034248 ! regulation of amide metabolic process +relationship: regulates GO:0043605 ! amide catabolic process + +[Term] +id: GO:0034252 +name: negative regulation of amide catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] +synonym: "negative regulation of amide breakdown" EXACT [] +synonym: "negative regulation of amide catabolism" EXACT [] +synonym: "negative regulation of amide degradation" RELATED [] +is_a: GO:0034249 ! negative regulation of amide metabolic process +is_a: GO:0034251 ! regulation of amide catabolic process +relationship: negatively_regulates GO:0043605 ! amide catabolic process + +[Term] +id: GO:0034253 +name: positive regulation of amide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] +synonym: "positive regulation of amide breakdown" EXACT [] +synonym: "positive regulation of amide catabolism" EXACT [] +synonym: "positive regulation of amide degradation" RELATED [] +is_a: GO:0034250 ! positive regulation of amide metabolic process +is_a: GO:0034251 ! regulation of amide catabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0043605 ! amide catabolic process + +[Term] +id: GO:0034254 +name: regulation of urea catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah] +synonym: "regulation of urea breakdown" EXACT [] +synonym: "regulation of urea catabolism" EXACT [] +synonym: "regulation of urea degradation" EXACT [] +is_a: GO:0034251 ! regulation of amide catabolic process +is_a: GO:0034255 ! regulation of urea metabolic process +relationship: regulates GO:0043419 ! urea catabolic process + +[Term] +id: GO:0034255 +name: regulation of urea metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah] +synonym: "regulation of urea metabolism" EXACT [] +is_a: GO:0034248 ! regulation of amide metabolic process +relationship: regulates GO:0019627 ! urea metabolic process + +[Term] +id: GO:0034256 +name: chlorophyll(ide) b reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 71-hydroxychlorophyllide a + NAD(P)+ = chlorophyllide b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678] +synonym: "Chl b reductase activity" EXACT [] +synonym: "chlorophyll b reductase activity" EXACT [] +synonym: "chlorophyllide b reductase activity" EXACT [] +xref: EC:1.1.1.294 +xref: MetaCyc:RXN-7678 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034257 +name: nicotinamide riboside transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0034258 +name: nicotinamide riboside transport +namespace: biological_process +def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of, within or between cells." [GOC:se] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0034259 +name: negative regulation of Rho GTPase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of activity of a GTPase of the Rho family." [GOC:mah] +synonym: "down regulation of Rho GTPase activity" EXACT [] +synonym: "down-regulation of Rho GTPase activity" EXACT [] +synonym: "downregulation of Rho GTPase activity" EXACT [] +synonym: "inhibition of Rho GTPase activity" NARROW [] +is_a: GO:0032319 ! regulation of Rho GTPase activity +is_a: GO:0034261 ! negative regulation of Ras GTPase activity + +[Term] +id: GO:0034260 +name: negative regulation of GTPase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GOC:mah] +synonym: "down regulation of GTPase activity" EXACT [] +synonym: "down-regulation of GTPase activity" EXACT [] +synonym: "downregulation of GTPase activity" EXACT [] +synonym: "inhibition of GTPase activity" NARROW [] +synonym: "negative regulation of guanosinetriphosphatase activity" EXACT [] +is_a: GO:0043087 ! regulation of GTPase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0034261 +name: negative regulation of Ras GTPase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of activity of a GTPase of the Ras superfamily." [GOC:mah] +synonym: "down regulation of Ras GTPase activity" EXACT [] +synonym: "down-regulation of Ras GTPase activity" EXACT [] +synonym: "downregulation of Ras GTPase activity" EXACT [] +synonym: "inhibition of Ras GTPase activity" NARROW [] +is_a: GO:0032318 ! regulation of Ras GTPase activity +is_a: GO:0034260 ! negative regulation of GTPase activity + +[Term] +id: GO:0034263 +name: autophagy in response to ER overload +namespace: biological_process +def: "The process by which cells digest parts of their own cytoplasm in response to the accumulation of misfolded proteins in the endoplasmic reticulum." [GOC:mah] +synonym: "autophagy in response to endoplasmic reticulum overload" EXACT [] +synonym: "autophagy in response to ER stress" EXACT [] +is_a: GO:0006914 ! autophagy +is_a: GO:0006983 ! ER overload response + +[Term] +id: GO:0034264 +name: isopentenyl adenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] +synonym: "isopentenyl adenine metabolism" EXACT [] +synonym: "isopentenyladenine metabolic process" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process + +[Term] +id: GO:0034265 +name: isopentenyl adenine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] +subset: gosubset_prok +synonym: "isopentenyl adenine anabolism" EXACT [] +synonym: "isopentenyl adenine biosynthesis" EXACT [] +synonym: "isopentenyl adenine formation" EXACT [] +synonym: "isopentenyl adenine synthesis" EXACT [] +synonym: "isopentenyladenine biosynthetic process" EXACT [] +is_a: GO:0009691 ! cytokinin biosynthetic process +is_a: GO:0034264 ! isopentenyl adenine metabolic process + +[Term] +id: GO:0034266 +name: isopentenyl adenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] +subset: gosubset_prok +synonym: "isopentenyl adenine breakdown" EXACT [] +synonym: "isopentenyl adenine catabolism" EXACT [] +synonym: "isopentenyl adenine degradation" EXACT [] +synonym: "isopentenyladenine catabolic process" EXACT [] +is_a: GO:0009823 ! cytokinin catabolic process +is_a: GO:0034264 ! isopentenyl adenine metabolic process + +[Term] +id: GO:0034267 +name: discadenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [ChEBI:15955, GOC:mah] +synonym: "discadenine metabolism" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process + +[Term] +id: GO:0034268 +name: discadenine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [ChEBI:15955, GOC:mah] +synonym: "discadenine anabolism" EXACT [] +synonym: "discadenine biosynthesis" EXACT [] +synonym: "discadenine formation" EXACT [] +synonym: "discadenine synthesis" EXACT [] +is_a: GO:0009691 ! cytokinin biosynthetic process +is_a: GO:0034267 ! discadenine metabolic process + +[Term] +id: GO:0034269 +name: discadenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [ChEBI:15955, GOC:mah] +synonym: "discadenine breakdown" EXACT [] +synonym: "discadenine catabolism" EXACT [] +synonym: "discadenine degradation" EXACT [] +is_a: GO:0009823 ! cytokinin catabolic process +is_a: GO:0034267 ! discadenine metabolic process + +[Term] +id: GO:0034270 +name: CVT complex +namespace: cellular_component +def: "A protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034271 +name: phosphatidylinositol 3-kinase complex I +namespace: cellular_component +def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Atg14p and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251] +comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. +synonym: "PtdIns-3-kinase complex I" EXACT [] +is_a: GO:0005942 ! phosphoinositide 3-kinase complex + +[Term] +id: GO:0034272 +name: phosphatidylinositol 3-kinase complex II +namespace: cellular_component +def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, VPS38 and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251] +comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. +synonym: "PtdIns-3-kinase complex II" EXACT [] +is_a: GO:0005942 ! phosphoinositide 3-kinase complex + +[Term] +id: GO:0034273 +name: Atg1p signaling complex +namespace: cellular_component +def: "A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p, Atg13p and Atg17p." [GOC:rb, PMID:15743910] +synonym: "Atg1p signalling complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034274 +name: Atg12-Atg5-Atg16 complex +namespace: cellular_component +def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034275 +name: kynurenic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [ChEBI:18344, GOC:mah] +synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT [] +synonym: "kynurenic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0034276 +name: kynurenic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [ChEBI:18344, GOC:mah] +synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT [] +synonym: "kynurenic acid anabolism" EXACT [] +synonym: "kynurenic acid biosynthesis" EXACT [] +synonym: "kynurenic acid formation" RELATED [] +synonym: "kynurenic acid synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0034275 ! kynurenic acid metabolic process + +[Term] +id: GO:0034277 +name: ent-cassa-12,15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [MetaCyc:RXN-4881] +xref: MetaCyc:RXN-4881 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034278 +name: stemar-13-ene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-syn-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882] +xref: MetaCyc:RXN-4882 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034279 +name: syn-pimara-7,15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-syn-copalyl diphosphate = (-)-9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883] +xref: MetaCyc:RXN-4883 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034280 +name: ent-sandaracopimaradiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimaradiene + diphosphate." [MetaCyc:RXN-4884] +synonym: "ent-pimaradiene synthase activity" BROAD [] +xref: MetaCyc:RXN-4884 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034281 +name: ent-isokaurene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034282 +name: ent-pimara-8(14),15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent- pimara-8(14),15-diene + diphosphate." [PMID:17141283] +synonym: "ent-pimaradiene synthase activity" BROAD [] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034283 +name: syn-stemod-13(17)-ene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: syn-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [PMID:17141283] +synonym: "exo-stemodene synthase activity" EXACT [] +synonym: "stemod-13(17)-ene synthase activity" EXACT [] +synonym: "stemodene synthase activity" EXACT [] +synonym: "syn-stemodene synthase activity" EXACT [] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034284 +name: response to monosaccharide stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0034285 +name: response to disaccharide stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart] +is_a: GO:0009743 ! response to carbohydrate stimulus + +[Term] +id: GO:0034286 +name: response to maltose stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart] +is_a: GO:0034285 ! response to disaccharide stimulus + +[Term] +id: GO:0034287 +name: detection of monosaccharide stimulus +namespace: biological_process +def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah] +synonym: "perception of monosaccharide stimulus" RELATED [] +is_a: GO:0009730 ! detection of carbohydrate stimulus +is_a: GO:0034284 ! response to monosaccharide stimulus + +[Term] +id: GO:0034288 +name: detection of disaccharide stimulus +namespace: biological_process +def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart] +synonym: "perception of disaccharide stimulus" RELATED [] +is_a: GO:0009730 ! detection of carbohydrate stimulus +is_a: GO:0034285 ! response to disaccharide stimulus + +[Term] +id: GO:0034289 +name: detection of maltose stimulus +namespace: biological_process +def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart] +synonym: "perception of maltose stimulus" RELATED [] +is_a: GO:0034286 ! response to maltose stimulus +is_a: GO:0034288 ! detection of disaccharide stimulus + +[Term] +id: GO:0034290 +name: holin activity +namespace: molecular_function +def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0034291 +name: canonical holin activity +namespace: molecular_function +def: "Catalysis of the temporally-regulated formation of a non-specific transmembrane protein hole that allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491] +is_a: GO:0034290 ! holin activity + +[Term] +id: GO:0034292 +name: pinholin activity +namespace: molecular_function +def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that allows the passage of ions, causing a lethal, irreversible depolarization of the cell membrane." [GOC:jh2, GOC:mah, PMID:1406491] +is_a: GO:0034290 ! holin activity + +[Term] +id: GO:0034293 +name: sexual sporulation +namespace: biological_process +def: "The formation of spores derived from the products of meiosis." [GOC:mah] +synonym: "meiotic spore formation" EXACT [] +synonym: "meiotic sporulation" EXACT [] +synonym: "sexual spore formation" EXACT [] +is_a: GO:0043934 ! sporulation +is_a: GO:0048610 ! reproductive cellular process + +[Term] +id: GO:0034294 +name: sexual spore wall assembly +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah] +subset: gosubset_prok +synonym: "sexual spore wall formation" EXACT [] +is_a: GO:0042244 ! spore wall assembly +relationship: part_of GO:0034293 ! sexual sporulation + +[Term] +id: GO:0034295 +name: basidiospore formation +namespace: biological_process +def: "The process by which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:ds, GOC:mah, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html] +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034296 +name: zygospore formation +namespace: biological_process +def: "The process by which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html] +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034297 +name: oidium formation +namespace: biological_process +def: "The process by which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html] +is_a: GO:0030436 ! asexual sporulation + +[Term] +id: GO:0034298 +name: arthrospore formation +namespace: biological_process +def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#arthrospore, http://www.ilmyco.gen.chicago.il.us/Terms/arthr620.html] +synonym: "arthroconidium formation" EXACT [http://medical.merriam-webster.com/medical/medical?book=Medical&va=arthroconidium] +is_a: GO:0048315 ! conidium formation + +[Term] +id: GO:0034299 +name: reproductive blastospore formation +namespace: biological_process +def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#blastospore, http://bugs.bio.usyd.edu.au/Mycology/Taxonomy/glomeromycota.shtml] +comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species. +synonym: "blastoconidium formation" EXACT [http://cancerweb.ncl.ac.uk/cgi-bin/omd?Blastoconidium] +is_a: GO:0048315 ! conidium formation + +[Term] +id: GO:0034300 +name: sporangiospore formation +namespace: biological_process +def: "The process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034301 +name: endospore formation +namespace: biological_process +def: "The process by which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, http://howie.myweb.uga.edu/introduction.html] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034302 +name: akinete formation +namespace: biological_process +def: "The process by which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034303 +name: myxospore formation +namespace: biological_process +def: "The process by which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034304 +name: actinomycete-type spore formation +namespace: biological_process +def: "The process by which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008] +is_a: GO:0022413 ! reproductive process in single-celled organism +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034305 +name: regulation of asexual sporulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah] +synonym: "regulation of asexual spore formation" EXACT [] +synonym: "regulation of mitotic spore formation" EXACT [] +synonym: "regulation of mitotic sporulation" EXACT [] +is_a: GO:0043937 ! regulation of sporulation +relationship: regulates GO:0030436 ! asexual sporulation + +[Term] +id: GO:0034306 +name: regulation of sexual sporulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis." [GOC:mah] +synonym: "MAPKKK cascade during sporulation (sensu Fungi)" NARROW [] +synonym: "regulation of meiotic spore formation" EXACT [] +synonym: "regulation of meiotic sporulation" EXACT [] +synonym: "regulation of sexual spore formation" EXACT [] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0034293 ! sexual sporulation + +[Term] +id: GO:0034307 +name: regulation of ascospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ascospore formation." [GOC:mah] +synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" NARROW [] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0030437 ! ascospore formation + +[Term] +id: GO:0034308 +name: monohydric alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one hydroxyl group attached to a saturated carbon atom." [ChEBI:30879, GOC:mah] +subset: gosubset_prok +synonym: "monohydric alcohol metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process + +[Term] +id: GO:0034309 +name: monohydric alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monohydric alcohols, any of a class of alkyl compounds containing a single hydroxyl group." [ChEBI:30879, GOC:mah] +subset: gosubset_prok +synonym: "monohydric alcohol anabolism" EXACT [] +synonym: "monohydric alcohol biosynthesis" EXACT [] +synonym: "monohydric alcohol formation" EXACT [] +synonym: "monohydric alcohol synthesis" EXACT [] +is_a: GO:0034308 ! monohydric alcohol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0034310 +name: monohydric alcohol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monohydric alcohols, any of a class of compounds containing a single hydroxyl group attached to a saturated carbon atom." [ChEBI:30879, GOC:mah] +subset: gosubset_prok +synonym: "monohydric alcohol breakdown" EXACT [] +synonym: "monohydric alcohol catabolism" EXACT [] +synonym: "monohydric alcohol degradation" EXACT [] +is_a: GO:0034308 ! monohydric alcohol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0034311 +name: diol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [ChEBI:23824, GOC:mah] +subset: gosubset_prok +synonym: "dihydric alcohol metabolic process" EXACT [] +synonym: "diol metabolism" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process + +[Term] +id: GO:0034312 +name: diol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [ChEBI:23824, GOC:mah] +synonym: "dihydric alcohol biosynthetic process" EXACT [] +synonym: "diol anabolism" EXACT [] +synonym: "diol biosynthesis" EXACT [] +synonym: "diol formation" EXACT [] +synonym: "diol synthesis" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0034313 +name: diol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [ChEBI:23824, GOC:mah] +synonym: "dihydric alcohol catabolic process" EXACT [] +synonym: "diol breakdown" EXACT [] +synonym: "diol catabolism" EXACT [] +synonym: "diol degradation" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0034314 +name: Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "The actin nucleation process by which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] +synonym: "actin filament branch nucleation" EXACT [] +synonym: "branched actin filament nucleation" EXACT [] +is_a: GO:0045010 ! actin nucleation + +[Term] +id: GO:0034315 +name: regulation of Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah] +is_a: GO:0051125 ! regulation of actin nucleation +relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation + +[Term] +id: GO:0034316 +name: negative regulation of Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963] +is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation +is_a: GO:0051126 ! negative regulation of actin nucleation +relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation + +[Term] +id: GO:0034317 +name: nicotinic acid riboside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinic acid riboside (NaR) = ADP + nicotinic acid mononucleotide (NaMN)." [PMID:17914902] +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0034318 +name: alcohol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah] +synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT [] +synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW [] +synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT [] +synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW [] +synonym: "AEATase activity" NARROW [] +synonym: "alcohol acyltransferase activity" EXACT [] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0034319 +name: alcohol O-butanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity +is_a: GO:0034323 ! O-butanoyltransferase activity + +[Term] +id: GO:0034320 +name: alcohol O-hexanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity +is_a: GO:0034324 ! O-hexanoyltransferase activity + +[Term] +id: GO:0034321 +name: alcohol O-octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0016414 ! O-octanoyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity + +[Term] +id: GO:0034322 +name: alcohol O-decanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity +is_a: GO:0034325 ! O-decanoyltransferase activity + +[Term] +id: GO:0034323 +name: O-butanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0034326 ! butanoyltransferase activity + +[Term] +id: GO:0034324 +name: O-hexanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0034327 ! hexanoyltransferase activity + +[Term] +id: GO:0034325 +name: O-decanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0034328 ! decanoyltransferase activity + +[Term] +id: GO:0034326 +name: butanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0034327 +name: hexanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0034328 +name: decanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0034329 +name: cell junction assembly +namespace: biological_process +def: "A cellular process that results in the assembly of a cell junction." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0034330 +name: cell junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] +synonym: "cell junction assembly and maintenance" EXACT [] +synonym: "cell junction biogenesis" RELATED [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0034331 +name: cell junction maintenance +namespace: biological_process +def: "The organization process by which a cell junction is preserved in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0034330 ! cell junction organization +is_a: GO:0043954 ! cellular component maintenance +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0034332 +name: adherens junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah] +synonym: "adherens junction assembly and maintenance" EXACT [] +synonym: "adherens junction organisation" EXACT [] +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0034333 +name: adherens junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] +synonym: "adherens junction formation" EXACT [] +is_a: GO:0034329 ! cell junction assembly +is_a: GO:0034332 ! adherens junction organization + +[Term] +id: GO:0034334 +name: adherens junction maintenance +namespace: biological_process +def: "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah] +is_a: GO:0034331 ! cell junction maintenance +is_a: GO:0034332 ! adherens junction organization + +[Term] +id: GO:0034335 +name: DNA supercoiling activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule." [GOC:mah] +comment: This term was made obsolete because, although it was requested, it is not needed after all; it was not defined clearly, and does not necessarily correspond to a catalytic activity. +is_obsolete: true +consider: GO:0015616 +consider: GO:0032392 + +[Term] +id: GO:0034336 +name: misfolded RNA binding +namespace: molecular_function +def: "Interacting selectively with an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192] +synonym: "RNA chaperone" RELATED [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0034337 +name: RNA folding +namespace: biological_process +def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192] +synonym: "RNA chaperone" RELATED [] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0034338 +name: short-chain carboxylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp] +subset: gosubset_prok +synonym: "butyrate esterase activity" NARROW [] +synonym: "butyryl esterase activity" NARROW [] +synonym: "methylbutyrase activity" NARROW [] +synonym: "methylbutyrate esterase activity" NARROW [] +synonym: "monobutyrase activity" NARROW [] +synonym: "propionyl esterase activity" NARROW [] +synonym: "short-chain esterase activity" BROAD [] +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0034339 +name: regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor +namespace: biological_process +def: "Any process by which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:mah, GOC:mh] +comment: This term was added by GO_REF:0000021. +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0034340 +name: response to type I interferon +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "response to type I IFN" EXACT [] +is_a: GO:0034097 ! response to cytokine stimulus +relationship: part_of GO:0045087 ! innate immune response + +[Term] +id: GO:0034341 +name: response to interferon-gamma +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383] +synonym: "response to gamma-interferon" RELATED [] +synonym: "response to immune interferon" EXACT [] +synonym: "response to type II IFN" EXACT [] +synonym: "response to type II interferon" EXACT [] +is_a: GO:0034097 ! response to cytokine stimulus +relationship: part_of GO:0045087 ! innate immune response + +[Term] +id: GO:0034342 +name: response to type III interferon +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +synonym: "response to interferon-lambda" EXACT [] +synonym: "response to type III IFN" EXACT [] +is_a: GO:0034097 ! response to cytokine stimulus +relationship: part_of GO:0045087 ! innate immune response + +[Term] +id: GO:0034343 +name: type III interferon production +namespace: biological_process +def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "type III IFN production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0034344 +name: regulation of type III interferon production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "regulation of type III IFN production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0034343 ! type III interferon production + +[Term] +id: GO:0034345 +name: negative regulation of type III interferon production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "down regulation of type III interferon production" EXACT [] +synonym: "down-regulation of type III interferon production" EXACT [] +synonym: "downregulation of type III interferon production" EXACT [] +synonym: "inhibition of type III interferon production" NARROW [] +synonym: "negative regulation of type III IFN production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0034344 ! regulation of type III interferon production +relationship: negatively_regulates GO:0034343 ! type III interferon production + +[Term] +id: GO:0034346 +name: positive regulation of type III interferon production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "activation of type III interferon production" NARROW [] +synonym: "positive regulation of type III IFN production" EXACT [] +synonym: "stimulation of type III interferon production" NARROW [] +synonym: "up regulation of type III interferon production" EXACT [] +synonym: "up-regulation of type III interferon production" EXACT [] +synonym: "upregulation of type III interferon production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0034344 ! regulation of type III interferon production +relationship: positively_regulates GO:0034343 ! type III interferon production + +[Term] +id: GO:0034347 +name: type III interferon binding +namespace: molecular_function +def: "Interacting selectively with a type III interferon. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "interferon-lambda binding" EXACT [] +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0034348 +name: type III interferon receptor activity +namespace: molecular_function +def: "Combining with a type III interferon to initiate a change in cell activity. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "interferon-lambda receptor activity" EXACT [] +is_a: GO:0004904 ! interferon receptor activity +is_a: GO:0034347 ! type III interferon binding + +[Term] +id: GO:0034349 +name: glial cell apoptosis +namespace: biological_process +def: "The process of apoptosis in glial cells." [GOC:sart] +synonym: "apoptosis of glia" EXACT [] +synonym: "apoptosis of glial cells" EXACT [] +synonym: "glia apoptosis" EXACT [] +synonym: "glia programmed cell death by apoptosis" EXACT [] +synonym: "glial cell programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of glia by apoptosis" EXACT [] +synonym: "programmed cell death of glial cells by apoptosis" EXACT [] +synonym: "programmed cell death, glia" EXACT [] +synonym: "programmed cell death, glial cells" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0034350 +name: regulation of glial cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of glial cell apoptosis." [GOC:mah] +is_a: GO:0042981 ! regulation of apoptosis +relationship: regulates GO:0034349 ! glial cell apoptosis + +[Term] +id: GO:0034351 +name: negative regulation of glial cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptosis." [GOC:mah] +synonym: "down regulation of glial cell apoptosis" EXACT [] +synonym: "down-regulation of glial cell apoptosis" EXACT [] +synonym: "downregulation of glial cell apoptosis" EXACT [] +synonym: "inhibition of glial cell apoptosis" NARROW [] +is_a: GO:0034350 ! regulation of glial cell apoptosis +is_a: GO:0043066 ! negative regulation of apoptosis +relationship: negatively_regulates GO:0034349 ! glial cell apoptosis + +[Term] +id: GO:0034352 +name: positive regulation of glial cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptosis." [GOC:mah] +synonym: "activation of glial cell apoptosis" NARROW [] +synonym: "stimulation of glial cell apoptosis" NARROW [] +synonym: "up regulation of glial cell apoptosis" EXACT [] +synonym: "up-regulation of glial cell apoptosis" EXACT [] +synonym: "upregulation of glial cell apoptosis" EXACT [] +is_a: GO:0034350 ! regulation of glial cell apoptosis +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: positively_regulates GO:0034349 ! glial cell apoptosis + +[Term] +id: GO:0034353 +name: RNA pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0034354 +name: de novo NAD biosynthetic process from tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604] +is_a: GO:0034627 ! de novo NAD biosynthetic process + +[Term] +id: GO:0034355 +name: NAD salvage +namespace: biological_process +def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681] +synonym: "NAD salvage pathway" EXACT [] +is_a: GO:0009435 ! NAD biosynthetic process + +[Term] +id: GO:0034356 +name: NAD biosynthesis via nicotinamide riboside salvage pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543] +synonym: "nicotinamide riboside salvage pathway" EXACT [] +synonym: "NR salvage pathway" EXACT [] +is_a: GO:0009435 ! NAD biosynthetic process + +[Term] +id: GO:0034357 +name: photosynthetic membrane +namespace: cellular_component +def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah] +subset: gosubset_prok +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0034358 +name: plasma lipoprotein particle +namespace: cellular_component +def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:expert_pt, GOC:rl] +is_a: GO:0032994 ! protein-lipid complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0034359 +name: mature chylomicron +namespace: cellular_component +def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0042627 ! chylomicron + +[Term] +id: GO:0034360 +name: chylomicron remnant +namespace: cellular_component +def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0042627 ! chylomicron + +[Term] +id: GO:0034361 +name: very-low-density lipoprotein particle +namespace: cellular_component +def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "very-low-density lipoprotein complex" EXACT [] +synonym: "VLDL complex" EXACT [] +synonym: "VLDL particle" EXACT [] +is_a: GO:0034385 ! triglyceride-rich lipoprotein particle + +[Term] +id: GO:0034362 +name: low-density lipoprotein particle +namespace: cellular_component +def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triacylglycerol and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "LDL complex" EXACT [] +synonym: "LDL particle" EXACT [] +synonym: "low-density lipoprotein complex" EXACT [] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0034363 +name: intermediate-density lipoprotein particle +namespace: cellular_component +def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "IDL complex" EXACT [] +synonym: "IDL particle" EXACT [] +synonym: "intermediate-density lipoprotein complex" EXACT [] +is_a: GO:0034385 ! triglyceride-rich lipoprotein particle + +[Term] +id: GO:0034364 +name: high-density lipoprotein particle +namespace: cellular_component +def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:expert_pt, GOC:mah, GOC:pd, GOC:rl] +synonym: "HDL complex" EXACT [] +synonym: "HDL particle" EXACT [] +synonym: "HDL2" RELATED [] +synonym: "HDL3" RELATED [] +synonym: "high-density lipoprotein class complex" EXACT [] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0034365 +name: discoidal high-density lipoprotein particle +namespace: cellular_component +def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "discoidal HDL" EXACT [] +synonym: "nascent HDL" EXACT [] +synonym: "nascent high-density lipoprotein particle" EXACT [] +is_a: GO:0034364 ! high-density lipoprotein particle + +[Term] +id: GO:0034366 +name: spherical high-density lipoprotein particle +namespace: cellular_component +def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "mature HDL" EXACT [] +synonym: "mature high-density lipoprotein particle" EXACT [] +synonym: "spherical HDL" EXACT [] +is_a: GO:0034364 ! high-density lipoprotein particle + +[Term] +id: GO:0034367 +name: macromolecular complex remodeling +namespace: biological_process +def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:mah, GOC:mtg_mpo, GOC:rl] +is_a: GO:0043933 ! macromolecular complex subunit organization + +[Term] +id: GO:0034368 +name: protein-lipid complex remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:mah, GOC:rl] +is_a: GO:0034367 ! macromolecular complex remodeling + +[Term] +id: GO:0034369 +name: plasma lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0034368 ! protein-lipid complex remodeling + +[Term] +id: GO:0034370 +name: triglyceride-rich lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034371 +name: chylomicron remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "chylomicron remnant formation" RELATED [] +is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling + +[Term] +id: GO:0034372 +name: very-low-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "IDL formation" RELATED [] +synonym: "intermediate-density lipoprotein particle formation" RELATED [] +synonym: "VLDL remodeling" EXACT [] +is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling + +[Term] +id: GO:0034373 +name: intermediate-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "IDL remodeling" EXACT [] +synonym: "LDL formation" RELATED [] +synonym: "low-density lipoprotein particle formation" RELATED [] +is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling + +[Term] +id: GO:0034374 +name: low-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "LDL remodeling" EXACT [] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034375 +name: high-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "HDL remodeling" EXACT [] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034376 +name: conversion of discoidal high-density lipoprotein to spherical high-density lipoprotein +namespace: biological_process +def: "The process by which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:mah, GOC:pd] +synonym: "conversion of discoidal HDL to spherical HDL" EXACT [] +synonym: "discoidal HDL remodeling" RELATED [] +synonym: "discoidal high-density lipoprotein remodeling" RELATED [] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034377 +name: plasma lipoprotein particle assembly +namespace: biological_process +def: "The aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:mah] +is_a: GO:0065005 ! protein-lipid complex assembly + +[Term] +id: GO:0034378 +name: chylomicron assembly +namespace: biological_process +def: "The aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:mah] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034379 +name: very-low-density lipoprotein particle assembly +namespace: biological_process +def: "The aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:mah] +synonym: "VLDL assembly" EXACT [] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034380 +name: high-density lipoprotein particle assembly +namespace: biological_process +def: "The aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:mah] +synonym: "HDL assembly" EXACT [] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034381 +name: lipoprotein particle clearance +namespace: biological_process +def: "The process by which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:mah] +is_a: GO:0032984 ! macromolecular complex disassembly + +[Term] +id: GO:0034382 +name: chylomicron remnant clearance +namespace: biological_process +def: "The process by which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:mah, GOC:pd] +is_a: GO:0034381 ! lipoprotein particle clearance + +[Term] +id: GO:0034383 +name: low-density lipoprotein particle clearance +namespace: biological_process +def: "The process by which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:mah] +synonym: "LDL clearance" EXACT [] +is_a: GO:0034381 ! lipoprotein particle clearance + +[Term] +id: GO:0034384 +name: high-density lipoprotein particle clearance +namespace: biological_process +def: "The process by which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:mah] +synonym: "HDL clearance" EXACT [] +is_a: GO:0034381 ! lipoprotein particle clearance + +[Term] +id: GO:0034385 +name: triglyceride-rich lipoprotein particle +namespace: cellular_component +def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:mah, GOC:rl] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0034386 +name: 4-aminobutyrate:2-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah] +synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-alpha-ketoglutaric acid transaminase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "GABA-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19] +is_a: GO:0003867 ! 4-aminobutyrate transaminase activity + +[Term] +id: GO:0034387 +name: 4-aminobutyrate:pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.19, GOC:mah] +synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.19] +is_a: GO:0003867 ! 4-aminobutyrate transaminase activity + +[Term] +id: GO:0034388 +name: Pwp2p-containing subcomplex of 90S preribosome +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "25-30 S subcomplex of 90S preribosome" EXACT [] +synonym: "UTP-B complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034389 +name: lipid particle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] +synonym: "adiposome organization and biogenesis" EXACT [] +synonym: "lipid body organization and biogenesis" EXACT [] +synonym: "lipid droplet organization and biogenesis" EXACT [] +synonym: "lipid particle organisation and biogenesis" EXACT [] +synonym: "lipid particle organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0034390 +name: smooth muscle cell apoptosis +namespace: biological_process +def: "The process of apoptosis in smooth muscle cells. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:mah, GOC:rl] +synonym: "apoptosis of smooth muscle cells" EXACT [] +synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] +synonym: "programmed cell death, smooth muscle cells" EXACT [] +synonym: "SMC apoptosis" EXACT [] +synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] +is_a: GO:0010657 ! muscle cell apoptosis + +[Term] +id: GO:0034391 +name: regulation of smooth muscle cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:rl] +synonym: "regulation of SMC apoptosis" EXACT [] +is_a: GO:0010660 ! regulation of muscle cell apoptosis +relationship: regulates GO:0034390 ! smooth muscle cell apoptosis + +[Term] +id: GO:0034392 +name: negative regulation of smooth muscle cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:rl] +synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] +synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] +synonym: "negative regulation of SMC apoptosis" EXACT [] +is_a: GO:0010656 ! negative regulation of muscle cell apoptosis +is_a: GO:0034391 ! regulation of smooth muscle cell apoptosis +relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptosis + +[Term] +id: GO:0034393 +name: positive regulation of smooth muscle cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:rl] +synonym: "activation of smooth muscle cell apoptosis" NARROW [] +synonym: "positive regulation of SMC apoptosis" EXACT [] +synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] +synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] +is_a: GO:0010661 ! positive regulation of muscle cell apoptosis +is_a: GO:0034391 ! regulation of smooth muscle cell apoptosis +relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptosis + +[Term] +id: GO:0034394 +name: protein localization at cell surface +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0034395 +name: regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah] +comment: This term was added by GO_REF:0000021. +synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT [] +is_a: GO:0010039 ! response to iron ion +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0034396 +name: negative regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah] +synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [] +synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT [] +is_a: GO:0010553 ! negative regulation of specific transcription from RNA polymerase II promoter +is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron + +[Term] +id: GO:0034397 +name: telomere localization +namespace: biological_process +def: "Any process by which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah] +is_a: GO:0051276 ! chromosome organization +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0034398 +name: telomere tethering at nuclear periphery +namespace: biological_process +def: "The process by which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah] +is_a: GO:0034397 ! telomere localization + +[Term] +id: GO:0034399 +name: nuclear periphery +namespace: cellular_component +def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0034400 +name: gerontoplast +namespace: cellular_component +def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0034401 +name: establishment or maintenance of chromatin architecture during transcription +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin during transcription." [GOC:curators] +is_a: GO:0006325 ! establishment or maintenance of chromatin architecture + +[Term] +id: GO:0034402 +name: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex +namespace: biological_process +def: "The process by which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0034403 +name: alignment of 3' and 5' splice sites of nuclear mRNA +namespace: biological_process +def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647] +is_a: GO:0000389 ! nuclear mRNA 3'-splice site recognition +is_a: GO:0000395 ! nuclear mRNA 5'-splice site recognition +relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step + +[Term] +id: GO:0034404 +name: nucleobase, nucleoside and nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides." [GOC:mah] +synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide formation" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT [] +is_a: GO:0034654 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process +is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process + +[Term] +id: GO:0034405 +name: response to fluid shear stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0034406 +name: cell wall beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +subset: gosubset_prok +synonym: "cell wall beta-glucan metabolism" EXACT [] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0034407 +name: cell wall 1,3-beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +subset: gosubset_prok +synonym: "cell wall 1,3-beta-glucan metabolism" EXACT [] +synonym: "cell wall beta-1,3 glucan metabolic process" EXACT [] +synonym: "cell wall beta-1,3 glucan metabolism" EXACT [] +is_a: GO:0006074 ! 1,3-beta-glucan metabolic process +is_a: GO:0034406 ! cell wall beta-glucan metabolic process + +[Term] +id: GO:0034408 +name: ascospore wall beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +subset: gosubset_prok +synonym: "ascospore wall beta-glucan metabolism" EXACT [] +is_a: GO:0006074 ! 1,3-beta-glucan metabolic process +is_a: GO:0034406 ! cell wall beta-glucan metabolic process + +[Term] +id: GO:0034409 +name: ascospore wall 1,3-beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +subset: gosubset_prok +synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [] +synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [] +synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [] +is_a: GO:0034407 ! cell wall 1,3-beta-glucan metabolic process +is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process + +[Term] +id: GO:0034410 +name: cell wall beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +subset: gosubset_prok +synonym: "cell wall beta-glucan anabolism" EXACT [] +synonym: "cell wall beta-glucan biosynthesis" EXACT [] +synonym: "cell wall beta-glucan formation" EXACT [] +synonym: "cell wall beta-glucan synthesis" EXACT [] +is_a: GO:0034406 ! cell wall beta-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0034411 +name: cell wall 1,3-beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +subset: gosubset_prok +synonym: "cell wall 1,3-beta-glucan anabolism" EXACT [] +synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT [] +synonym: "cell wall 1,3-beta-glucan formation" EXACT [] +synonym: "cell wall 1,3-beta-glucan synthesis" EXACT [] +synonym: "cell wall beta-1,3-glucan anabolism" EXACT [] +synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT [] +synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT [] +synonym: "cell wall beta-1,3-glucan formation" EXACT [] +synonym: "cell wall beta-1,3-glucan synthesis" EXACT [] +is_a: GO:0006075 ! 1,3-beta-glucan biosynthetic process +is_a: GO:0034407 ! cell wall 1,3-beta-glucan metabolic process + +[Term] +id: GO:0034412 +name: ascospore wall beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +subset: gosubset_prok +synonym: "ascospore wall beta-glucan anabolism" EXACT [] +synonym: "ascospore wall beta-glucan biosynthesis" EXACT [] +synonym: "ascospore wall beta-glucan formation" EXACT [] +synonym: "ascospore wall beta-glucan synthesis" EXACT [] +is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0034413 +name: ascospore wall 1,3-beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +subset: gosubset_prok +synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan formation" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT [] +synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT [] +synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT [] +synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT [] +synonym: "ascospore wall beta-1,3-glucan formation" EXACT [] +synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT [] +is_a: GO:0034409 ! ascospore wall 1,3-beta-glucan metabolic process +is_a: GO:0034411 ! cell wall 1,3-beta-glucan biosynthetic process +is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process + +[Term] +id: GO:0034414 +name: tRNA 3'-trailer cleavage, endonucleolytic +namespace: biological_process +def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] +synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT [] +synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED [] +synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT [] +is_a: GO:0042779 ! tRNA 3'-trailer cleavage + +[Term] +id: GO:0034415 +name: tRNA 3'-trailer cleavage, exonucleolytic +namespace: biological_process +def: "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] +synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT [] +synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT [] +synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT [] +is_a: GO:0042779 ! tRNA 3'-trailer cleavage + +[Term] +id: GO:0034416 +name: bisphosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611] +synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] +synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] +synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [EC:3.1.3.13] +synonym: "diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13] +synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [EC:3.1.3.13] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0034417 +name: bisphosphoglycerate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611] +synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" EXACT [EC:3.1.3.13] +is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity + +[Term] +id: GO:0034418 +name: urate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah] +synonym: "urate anabolism" RELATED [] +synonym: "urate biosynthesis" EXACT [] +synonym: "urate formation" EXACT [] +synonym: "urate synthesis" EXACT [] +synonym: "uric acid biosynthetic process" EXACT [] +is_a: GO:0044271 ! nitrogen compound biosynthetic process +is_a: GO:0046415 ! urate metabolic process + +[Term] +id: GO:0034419 +name: L-2-hydroxyglutarate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2." [PMID:18390652] +is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity + +[Term] +id: GO:0034420 +name: co-translational protein amino acid acetylation +namespace: biological_process +def: "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah] +synonym: "cotranslational protein amino acid acetylation" EXACT [] +is_a: GO:0006473 ! protein amino acid acetylation +is_a: GO:0043686 ! co-translational protein modification + +[Term] +id: GO:0034421 +name: post-translational protein amino acid acetylation +namespace: biological_process +def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah] +synonym: "posttranslational protein amino acid acetylation" EXACT [] +is_a: GO:0006473 ! protein amino acid acetylation + +[Term] +id: GO:0034422 +name: aleurone grain lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0033095 ! aleurone grain + +[Term] +id: GO:0034423 +name: autophagic vacuole lumen +namespace: cellular_component +def: "The volume enclosed within the autophagic vacuole membrane." [GOC:rph] +comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation. +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0005776 ! autophagic vacuole + +[Term] +id: GO:0034424 +name: Vps55/Vps68 complex +namespace: cellular_component +def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044440 ! endosomal part +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0034425 +name: etioplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0034426 +name: etioplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0034425 ! etioplast envelope + +[Term] +id: GO:0034427 +name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah] +synonym: "3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic + +[Term] +id: GO:0034428 +name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah] +synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic + +[Term] +id: GO:0034429 +name: tectobulbar tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0034430 +name: monolayer-surrounded lipid storage body outer lipid monolayer +namespace: cellular_component +def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph] +synonym: "lipid droplet outer lipid monolayer" RELATED [] +synonym: "lipid storage body surface lipid monolayer" EXACT [] +synonym: "oil body outer lipid monolayer" EXACT [] +synonym: "oleosome outer lipid monolayer" EXACT [] +synonym: "spherosome outer lipid monolayer" EXACT [] +is_a: GO:0034646 ! organelle-enclosing lipid monolayer +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body + +[Term] +id: GO:0034431 +name: bis(5'-adenosyl)-hexaphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008] +synonym: "AP(6)A hydrolase activity" EXACT [] +synonym: "AP-6-A hydrolase activity" EXACT [] +synonym: "AP6A hydrolase activity" EXACT [] +synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT [] +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0034432 +name: bis(5'-adenosyl)-pentaphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008] +synonym: "AP(5)A hydrolase activity" EXACT [] +synonym: "AP-5-A hydrolase activity" EXACT [] +synonym: "AP5A hydrolase activity" EXACT [] +synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT [] +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0034433 +name: steroid esterification +namespace: biological_process +def: "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:mah, GOC:pd, GOC:rl] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034434 +name: sterol esterification +namespace: biological_process +def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:mah, GOC:pd, GOC:rl] +is_a: GO:0034433 ! steroid esterification + +[Term] +id: GO:0034435 +name: cholesterol esterification +namespace: biological_process +def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:mah, GOC:pd, GOC:rl] +is_a: GO:0034434 ! sterol esterification + +[Term] +id: GO:0034436 +name: glycoprotein transport +namespace: biological_process +def: "The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid, into, out of, within or between cells." [GOC:mah, GOC:rl] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0034437 +name: glycoprotein transporter activity +namespace: molecular_function +def: "Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid, into, out of, within or between cells." [GOC:mah, GOC:rl] +is_a: GO:0008565 ! protein transporter activity + +[Term] +id: GO:0034438 +name: lipoprotein amino acid oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:mah] +subset: gosubset_prok +is_a: GO:0018158 ! protein amino acid oxidation +is_a: GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034439 +name: lipoprotein lipid oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of the lipid moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0034440 ! lipid oxidation +is_a: GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034440 +name: lipid oxidation +namespace: biological_process +def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:mah] +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034441 +name: plasma lipoprotein oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid moiety, occurring in the blood plasma." [GOC:mah] +is_a: GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034442 +name: regulation of lipoprotein oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:mah] +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +relationship: regulates GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034443 +name: negative regulation of lipoprotein oxidation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:mah] +synonym: "inhibition of lipoprotein oxidation" NARROW [] +is_a: GO:0034442 ! regulation of lipoprotein oxidation +is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process +relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034444 +name: regulation of plasma lipoprotein oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:mah] +is_a: GO:0034442 ! regulation of lipoprotein oxidation +relationship: regulates GO:0034441 ! plasma lipoprotein oxidation + +[Term] +id: GO:0034445 +name: negative regulation of plasma lipoprotein oxidation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:mah] +synonym: "inhibition of plasma lipoprotein oxidation" NARROW [] +is_a: GO:0034443 ! negative regulation of lipoprotein oxidation +is_a: GO:0034444 ! regulation of plasma lipoprotein oxidation +relationship: negatively_regulates GO:0034441 ! plasma lipoprotein oxidation + +[Term] +id: GO:0034446 +name: substrate adhesion-dependent cell spreading +namespace: biological_process +def: "The morphogenetic process by which flattening of a cell takes place as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732] +synonym: "cell spreading during cell substrate adhesion" EXACT [] +synonym: "substrate adhesion dependent cell spreading" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0034447 +name: very-low-density lipoprotein particle clearance +namespace: biological_process +def: "The process by which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:rl] +synonym: "VLDL clearance" EXACT [] +is_a: GO:0034381 ! lipoprotein particle clearance + +[Term] +id: GO:0034448 +name: EGO complex +namespace: cellular_component +def: "A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Meh1p, Gtr2p and Slm4p." [GOC:rb, PMID:15989961] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0034449 +name: GSE complex +namespace: cellular_component +def: "A conserved protein complex required for protein sorting from endosome to the plasma membrane. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Slm4p, Meh1p and Ltv1p and it sorts Gap1p." [GOC:rb, PMID:15989961] +synonym: "GTPase-containing complex for Gap1p sorting in the endosome" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044440 ! endosomal part + +[Term] +id: GO:0034450 +name: ubiquitin-ubiquitin ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] +synonym: "E4" EXACT [] +is_a: GO:0004842 ! ubiquitin-protein ligase activity + +[Term] +id: GO:0034451 +name: centriolar satellite +namespace: cellular_component +def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; cetriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [PMID:10579718, PMID:12403812] +is_a: GO:0044450 ! microtubule organizing center part +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0034452 +name: dynactin binding +namespace: molecular_function +def: "Interacting selectively with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:mah] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0034453 +name: microtubule anchoring +namespace: biological_process +def: "Any process by which a microtubule is maintained in a specific location in a cell." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0034454 +name: microtubule anchoring at centrosome +namespace: biological_process +def: "Any process by which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:mah] +is_a: GO:0034453 ! microtubule anchoring + +[Term] +id: GO:0034455 +name: t-UTP complex +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:mah, PMID:17515605] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034456 +name: UTP-C complex +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034457 +name: Mpp10 complex +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0043234 ! protein complex +is_a: GO:0044452 ! nucleolar part +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034458 +name: 3'-5' RNA helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of an RNA helix in the direction 3' to 5'." [GOC:mah] +synonym: "3' to 5' RNA helicase activity" EXACT [] +is_a: GO:0003724 ! RNA helicase activity + +[Term] +id: GO:0034459 +name: ATP-dependent 3'-5' RNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix in the direction 3' to 5'." [GOC:jp] +synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT [] +is_a: GO:0004004 ! ATP-dependent RNA helicase activity +is_a: GO:0034458 ! 3'-5' RNA helicase activity + +[Term] +id: GO:0034460 +name: uropod formation +namespace: biological_process +def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah] +is_a: GO:0032796 ! uropod organization + +[Term] +id: GO:0034461 +name: uropod retraction +namespace: biological_process +def: "The process by which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379] +is_a: GO:0032796 ! uropod organization + +[Term] +id: GO:0034462 +name: small-subunit processome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah] +synonym: "small subunit processome assembly" EXACT [] +synonym: "SSU processome assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000028 ! ribosomal small subunit assembly and maintenance + +[Term] +id: GO:0034463 +name: 90S preribosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome." [GOC:mah] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000027 ! ribosomal large subunit assembly and maintenance +relationship: part_of GO:0000028 ! ribosomal small subunit assembly and maintenance + +[Term] +id: GO:0034464 +name: BBSome +namespace: cellular_component +def: "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [PMID:17574030] +synonym: "Bardet-Biedl syndrome complex" EXACT [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0034465 +name: response to carbon monoxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0034466 +name: chromaffin granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0042583 ! chromaffin granule + +[Term] +id: GO:0034467 +name: esterosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an esterosome." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0033117 ! esterosome + +[Term] +id: GO:0034468 +name: glycosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a glycosome." [GOC:rph] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0020015 ! glycosome + +[Term] +id: GO:0034469 +name: Golgi stack lumen +namespace: cellular_component +def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah] +is_a: GO:0005796 ! Golgi lumen +relationship: part_of GO:0005795 ! Golgi stack + +[Term] +id: GO:0034470 +name: ncRNA processing +namespace: biological_process +def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0034471 +name: ncRNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah] +synonym: "ncRNA 5' end processing" EXACT [] +is_a: GO:0000966 ! RNA 5'-end processing +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0034472 +name: snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] +synonym: "snRNA 3'-end processing" EXACT [] +is_a: GO:0016180 ! snRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0034473 +name: U1 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah] +synonym: "U1 snRNA 3'-end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034474 +name: U2 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah] +synonym: "U2 snRNA 3'-end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034475 +name: U4 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah] +synonym: "U4 snRNA 3'-end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034476 +name: U5 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah] +synonym: "U5 snRNA 3'-end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034477 +name: U6 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah] +synonym: "U6 snRNA 3'-end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034478 +name: phosphatidylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah] +subset: gosubset_prok +synonym: "phosphatidylglycerol breakdown" EXACT [] +synonym: "phosphatidylglycerol catabolism" EXACT [] +synonym: "phosphatidylglycerol degradation" EXACT [] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0034479 +name: phosphatidylglycerol phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318] +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0034480 +name: phosphatidylcholine phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate." [EC:3.1.4.3, GOC:mah] +subset: gosubset_prok +synonym: "alpha-toxin" NARROW [EC:3.1.4.3] +synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3] +synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3] +synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3] +synonym: "lipophosphodiesterase I activity" EXACT [EC:3.1.4.3] +synonym: "phosphatidylcholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.3] +synonym: "phospholipase C, acting on phosphatidylcholine" EXACT [] +xref: EC:3.1.4.3 +xref: MetaCyc:PHOSPHOLIPASE-C-RXN +xref: Reactome:11457 +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0034481 +name: chondroitin sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [EC:2.8.2.17, EC:2.8.2.5, GOC:mah] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0034482 +name: chondroitin 2-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754] +synonym: "chondroitin 2-O-sulphotransferase activity" EXACT [] +synonym: "chondroitin 2-sulfotransferase activity" EXACT [] +xref: EC:2.8.2.17 +xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN +is_a: GO:0034481 ! chondroitin sulfotransferase activity + +[Term] +id: GO:0034483 +name: heparan sulfate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0034484 +name: raffinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:16634, GOC:mah] +synonym: "raffinose breakdown" EXACT [] +synonym: "raffinose catabolism" EXACT [] +synonym: "raffinose degradation" EXACT [] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0033530 ! raffinose metabolic process + +[Term] +id: GO:0034485 +name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 3,4-bisphosphate + phosphate." [GOC:pf] +is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity +is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity + +[Term] +id: GO:0034486 +name: vacuolar transmembrane transport +namespace: biological_process +def: "The process whereby a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] +is_a: GO:0007034 ! vacuolar transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034487 +name: vacuolar amino acid transport +namespace: biological_process +def: "The process whereby an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] +synonym: "vacuolar amino acid transmembrane transport" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0034486 ! vacuolar transmembrane transport + +[Term] +id: GO:0034488 +name: basic amino acid export from vacuole +namespace: biological_process +def: "The directed movement of basic amino acids out of the vacuole." [GOC:mah] +is_a: GO:0015802 ! basic amino acid transport +is_a: GO:0032974 ! amino acid export from vacuole + +[Term] +id: GO:0034489 +name: neutral amino acid export from vacuole +namespace: biological_process +def: "The directed movement of neutral amino acids out of the vacuole." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0032974 ! amino acid export from vacuole + +[Term] +id: GO:0034490 +name: basic amino acid import into vacuole +namespace: biological_process +def: "The directed movement of basic amino acids into the vacuole." [GOC:mah] +is_a: GO:0015802 ! basic amino acid transport +is_a: GO:0032975 ! amino acid import into vacuole + +[Term] +id: GO:0034491 +name: neutral amino acid import into vacuole +namespace: biological_process +def: "The directed movement of neutral amino acids into the vacuole." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0032975 ! amino acid import into vacuole + +[Term] +id: GO:0034492 +name: hydrogenosome lumen +namespace: cellular_component +def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0042566 ! hydrogenosome + +[Term] +id: GO:0034493 +name: melanosome lumen +namespace: cellular_component +def: "The volume enclosed by the melanosome membrane." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0042470 ! melanosome + +[Term] +id: GO:0034494 +name: microneme lumen +namespace: cellular_component +def: "The volume enclosed by the microneme membrane." [GOC:rph] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0020009 ! microneme + +[Term] +id: GO:0034495 +name: protein storage vacuole lumen +namespace: cellular_component +def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph] +is_a: GO:0000330 ! plant-type vacuole lumen +relationship: part_of GO:0000326 ! protein storage vacuole + +[Term] +id: GO:0034496 +name: multivesicular body membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb] +synonym: "MVB membrane disassembly" EXACT [] +is_a: GO:0030397 ! membrane disassembly + +[Term] +id: GO:0034497 +name: protein localization to pre-autophagosomal structure +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS)." [GOC:rb] +synonym: "protein localization to PAS" EXACT [] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0034498 +name: early endosome to Golgi transport +namespace: biological_process +def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb] +synonym: "PGE to Golgi transport" EXACT [] +synonym: "post-Golgi endosome to Golgi transport" EXACT [] +is_a: GO:0042147 ! retrograde transport, endosome to Golgi +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0034499 +name: late endosome to Golgi transport +namespace: biological_process +def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb] +synonym: "prevacuolar endosome to Golgi transport" EXACT [] +synonym: "PVE to Golgi transport" EXACT [] +is_a: GO:0042147 ! retrograde transport, endosome to Golgi +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0034500 +name: rDNA separation +namespace: biological_process +def: "The cell cycle process whereby rDNA repeat regions are physically detached from each other during chromosome separation." [GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051304 ! chromosome separation + +[Term] +id: GO:0034501 +name: protein localization to kinetochore +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] +synonym: "condensin localization to kinetochore" NARROW [] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0034502 +name: protein localization to chromosome +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] +synonym: "condensin localization to chromosome" NARROW [] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0034503 +name: protein localization to nucleolar rDNA repeats +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah] +synonym: "condensin localization to nucleolar rDNA repeats" NARROW [] +is_a: GO:0034502 ! protein localization to chromosome + +[Term] +id: GO:0034504 +name: protein localization in nucleus +namespace: biological_process +def: "A process by which a protein is transported to, or maintained in, a location within the nucleus." [GOC:ecd] +synonym: "protein localization in cell nucleus" EXACT [] +is_a: GO:0033365 ! protein localization in organelle + +[Term] +id: GO:0034505 +name: tooth mineralization +namespace: biological_process +def: "The process by which calcium salts are deposited into calcareous tooth structure such as dental enamel, dentin and cementum." [GOC:mah, MESH:tooth+calcification, MP:0002817] +synonym: "tooth calcification" EXACT [] +is_a: GO:0031214 ! biomineral formation +relationship: part_of GO:0042476 ! odontogenesis + +[Term] +id: GO:0034506 +name: chromosome, centromeric core region +namespace: cellular_component +def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:val] +synonym: "chromosome, centric core region" RELATED [] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0034507 +name: chromosome, centromeric outer repeat region +namespace: cellular_component +def: "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:val] +synonym: "chromosome, centric outer repeat region" RELATED [] +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0034508 +name: centromere complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] +is_a: GO:0051276 ! chromosome organization +is_a: GO:0065004 ! protein-DNA complex assembly + +[Term] +id: GO:0034509 +name: centromeric core chromatin formation +namespace: biological_process +def: "The assembly of chromatin into the specialized structure characteristic of the centromeric core region, defined by the presence of the variant histone CENP-A." [GOC:mah, GOC:vw] +synonym: "centric core chromatin formation" EXACT [] +synonym: "centromeric core chromatin assembly" EXACT [] +is_a: GO:0031497 ! chromatin assembly +relationship: part_of GO:0034508 ! centromere complex assembly + +[Term] +id: GO:0034510 +name: centromere separation +namespace: biological_process +def: "The cell cycle process whereby centromeres are physically detached from each other during chromosome separation." [GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051304 ! chromosome separation + +[Term] +id: GO:0034511 +name: U3 snoRNA binding +namespace: molecular_function +def: "Interacting selectively with U3 small nucleolar RNA." [GOC:mah] +is_a: GO:0030515 ! snoRNA binding + +[Term] +id: GO:0034512 +name: box C/D snoRNA binding +namespace: molecular_function +def: "Interacting selectively with box C/D small nucleolar RNA." [GOC:mah] +is_a: GO:0030515 ! snoRNA binding + +[Term] +id: GO:0034513 +name: box H/ACA snoRNA binding +namespace: molecular_function +def: "Interacting selectively with box H/ACA small nucleolar RNA." [GOC:mah] +is_a: GO:0030515 ! snoRNA binding + +[Term] +id: GO:0034514 +name: mitochondrial unfolded protein response +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004] +synonym: "mtUPR" EXACT [] +is_a: GO:0034620 ! cellular response to unfolded protein + +[Term] +id: GO:0034515 +name: proteasome storage granule +namespace: cellular_component +def: "A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:rb, PMID:18504300] +synonym: "PSG" EXACT [] +is_a: GO:0031597 ! cytosolic proteasome complex + +[Term] +id: GO:0034516 +name: response to vitamin B6 +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0034517 +name: ribophagy +namespace: biological_process +def: "The process by which cells degrade mature ribosomes under conditions of starvation." [PMID:18391941] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0034518 +name: RNA cap binding complex +namespace: cellular_component +def: "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA." [GOC:mah] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0034519 +name: cytoplasmic RNA cap binding complex +namespace: cellular_component +def: "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910] +is_a: GO:0034518 ! RNA cap binding complex + +[Term] +id: GO:0034520 +name: 2-naphthaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0483 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034521 +name: 1-naphthoic acid dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0484 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034522 +name: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2H+ + 2e-." [UM-BBD_reactionID:r0774] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0485 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034523 +name: 3-formylsalicylate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-formylsalicylic acid +O2 + H2O = 2-hydroxyisophthalic acid +H2O2." [UM-BBD_reactionID:r0777] +xref: EC:1.2.3.- +xref: UM-BBD_enzymeID:e0486 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0034524 +name: 2-hydroxyisophthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [UM-BBD_reactionID:r0776] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0487 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034525 +name: 1-naphthaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [UM-BBD_reactionID:r0787] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0489 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034526 +name: 2-methylnaphthalene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAH+ + H2O." [UM-BBD_reactionID:r0788] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0490 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034527 +name: 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene +O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [UM-BBD_reactionID:r0790] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0491 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034528 +name: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791] +xref: EC:5.3.99.- +xref: UM-BBD_enzymeID:e0492 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034529 +name: 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [UM-BBD_reactionID:r0792] +xref: EC:4.1.2.- +xref: UM-BBD_enzymeID:e0493 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0034530 +name: 4-hydroxymethylsalicyaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2H+." [UM-BBD_reactionID:r0767] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0495 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034531 +name: 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [UM-BBD_reactionID:r0766] +xref: EC:4.1.2.- +xref: UM-BBD_enzymeID:e0496 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0034532 +name: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765] +xref: EC:5.3.99.- +xref: UM-BBD_enzymeID:e0497 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034533 +name: 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [UM-BBD_reactionID:r0764] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0498 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034534 +name: 1-methylnaphthalene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0500 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034535 +name: 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [UM-BBD_reactionID:r0781] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0501 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034536 +name: 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782] +xref: EC:5.3.99.- +xref: UM-BBD_enzymeID:e0502 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034537 +name: 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [UM-BBD_reactionID:r0783] +xref: EC:4.1.2.- +xref: UM-BBD_enzymeID:e0503 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0034538 +name: 3-methylsalicylaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [UM-BBD_reactionID:r0784] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0504 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034539 +name: 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',5,5'-Tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0510 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034540 +name: 3-monobromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-monobromobisphenol A+ 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0513 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034541 +name: dimethylarsinite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [UM-BBD_reactionID:r0806] +xref: EC:2.1.1.- +xref: UM-BBD_enzymeID:e0516 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034542 +name: trimethylarsine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0517 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034543 +name: 5-aminosalicylate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0518 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034544 +name: trans-ACOHDA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810] +xref: EC:3.5.99.- +xref: UM-BBD_enzymeID:e0519 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034545 +name: fumarylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0520 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034546 +name: 2,4-dichloroaniline reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0521 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034547 +name: N-cyclopropylmelamine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825] +xref: EC:3.5.4.- +xref: UM-BBD_enzymeID:e0524 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0034548 +name: N-cyclopropylammeline deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826] +xref: EC:3.5.4.- +xref: UM-BBD_enzymeID:e0525 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0034549 +name: N-cyclopropylammelide alkylamino hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827] +xref: EC:3.5.4.- +xref: UM-BBD_enzymeID:e0526 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0034550 +name: dimethylarsinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0529 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034551 +name: mitochondrial cytochrome bc(1) complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as cytochrome c oxidase), in the mitochondrial inner membrane." [GOC:df] +is_a: GO:0017062 ! cytochrome bc(1) complex assembly +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly + +[Term] +id: GO:0034552 +name: respiratory chain complex II assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:df] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0034553 +name: mitochondrial respiratory chain complex II assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:df] +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly +is_a: GO:0034552 ! respiratory chain complex II assembly + +[Term] +id: GO:0034554 +name: 3,3',5-tribromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0532 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034555 +name: 3,3'-dibromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0533 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034556 +name: nitrobenzoate nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [UM-BBD_reactionID:r0849] +xref: EC:1.7.1.- +xref: UM-BBD_enzymeID:e0536 +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0034557 +name: o-hydroxylaminobenzoate nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: o-hydroxylaminobenzoate + 2 H+ + 2 e-= 2-aminobenzoate + H2O." [UM-BBD_reactionID:r0850] +xref: EC:1.4.-.- +xref: UM-BBD_enzymeID:e0537 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0034558 +name: technetium (VII) reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [UM-BBD_reactionID:r0859] +xref: EC:1.12.-.- +xref: UM-BBD_enzymeID:e0542 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0034559 +name: bisphenol A hydroxylase B activity +namespace: molecular_function +def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0860] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0543 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034560 +name: bisphenol A hydroxylase A activity +namespace: molecular_function +def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0544 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034561 +name: 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [UM-BBD_reactionID:r0862] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0545 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034562 +name: 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [UM-BBD_reactionID:r0864] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0547 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034563 +name: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2e-." [UM-BBD_reactionID:r0867] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0548 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034564 +name: 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0866] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0549 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034565 +name: 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872] +xref: EC:3.5.99.- +xref: UM-BBD_enzymeID:e0552 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034566 +name: formamide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: formamide + H2O = formate + NH3 + H+." [UM-BBD_reactionID:r0873] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0554 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034567 +name: chromate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chromate = chromium (III)." [UM-BBD_reactionID:r0884] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0556 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034568 +name: isoproturon dimethylaminedehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892] +xref: EC:1.5.99.- +xref: UM-BBD_enzymeID:e0561 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034569 +name: monodemethylisoproturon dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2H+ + 2 e-." [UM-BBD_reactionID:r0893] +xref: EC:1.17.99.- +xref: UM-BBD_enzymeID:e0562 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0034570 +name: hydroxymonomethylisoproturon dimethylaminedehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894] +xref: EC:1.5.99.- +xref: UM-BBD_enzymeID:e0563 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034571 +name: 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [UM-BBD_reactionID:r0895] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0564 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034572 +name: monodemethylisoproturon dimethylaminedehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897] +xref: EC:1.5.99.- +xref: UM-BBD_enzymeID:e0565 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034573 +name: didemethylisoproturon amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [UM-BBD_reactionID:r0898] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0566 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034574 +name: didemethylisoproturon dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899] +xref: EC:1.17.99.- +xref: UM-BBD_enzymeID:e0567 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0034575 +name: 4-isopropylaniline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901] +xref: EC:1.17.99.- +xref: UM-BBD_enzymeID:e0569 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0034576 +name: N-isopropylacetanilide amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [UM-BBD_reactionID:r0913] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0570 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034577 +name: N-isopropylacetaniline monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914] +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0571 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034578 +name: limonene 8-hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: limonene + H2O = alpha-terpineol." [UM-BBD_reactionID:r0916] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0572 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034579 +name: (1-methylpentyl)succinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [UM-BBD_reactionID:r0920] +xref: EC:4.1.99.- +xref: UM-BBD_enzymeID:e0573 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0034580 +name: 4-methyloctanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924] +xref: EC:1.3.99.- +xref: UM-BBD_enzymeID:e0577 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034581 +name: 4-methyloct-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [UM-BBD_reactionID:r0925] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0578 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034582 +name: 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0926] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0579 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034583 +name: 21U-RNA binding +namespace: molecular_function +def: "Interacting selectively with a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0034584 +name: piRNA binding +namespace: molecular_function +def: "Interacting selectively with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] +synonym: "Piwi-associated RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0034585 +name: 21U-RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] +synonym: "21U-RNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034586 +name: 21U-RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] +synonym: "21U-RNA breakdown" EXACT [] +synonym: "21U-RNA catabolism" EXACT [] +synonym: "21U-RNA degradation" EXACT [] +is_a: GO:0034585 ! 21U-RNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0034587 +name: piRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] +synonym: "piRNA metabolism" EXACT [] +synonym: "Piwi-associated RNA metabolic process" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034588 +name: piRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] +synonym: "piRNA breakdown" EXACT [] +synonym: "piRNA catabolism" EXACT [] +synonym: "piRNA degradation" EXACT [] +synonym: "Piwi-associated RNA catabolic process" EXACT [] +is_a: GO:0034587 ! piRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0034589 +name: hydroxyproline transport +namespace: biological_process +def: "The directed movement of hydroxyproline into, out of, within or between cells." [GOC:mah, PMID:14502423] +synonym: "4-hydroxyproline transport" EXACT [] +synonym: "L-hydroxyproline transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0034590 +name: L-hydroxyproline transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423] +synonym: "4-hydroxyproline transmembrane transporter activity" BROAD [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0034591 +name: rhoptry lumen +namespace: cellular_component +def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128] +is_a: GO:0043233 ! organelle lumen +is_a: GO:0044464 ! cell part +relationship: part_of GO:0020008 ! rhoptry + +[Term] +id: GO:0034592 +name: synaptic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0008021 ! synaptic vesicle + +[Term] +id: GO:0034593 +name: phosphatidylinositol bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of one of the two phosphate groups of a phosphatidylinositol bisphosphate." [GOC:mah] +synonym: "diphosphoinositide phosphatase activity" RELATED [] +synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT [] +synonym: "phosphatidylinositol-bisphosphatase activity" RELATED [] +synonym: "triphosphoinositide phosphatase activity" RELATED [] +synonym: "triphosphoinositide phosphomonoesterase activity" RELATED [] +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0034594 +name: phosphatidylinositol trisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of one of the three phosphate groups of a phosphatidylinositol trisphosphate." [GOC:mah] +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0034595 +name: phosphoinositide 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal the of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh] +subset: gosubset_prok +synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT [] +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0034596 +name: phosphoinositide 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal the of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah] +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0034597 +name: phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] +synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] +synonym: "D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] +synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] +synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] +xref: EC:3.1.3.66 +xref: MetaCyc:3.1.3.66-RXN +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity +is_a: GO:0034596 ! phosphoinositide 4-phosphatase activity +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0034598 +name: phosphothreonine lyase activity +namespace: molecular_function +def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034599 +name: cellular response to oxidative stress +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0034601 +name: oxoglutarate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [GOC:mah] +xref: EC:1.2.1.52 +xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034602 +name: oxoglutarate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah] +xref: EC:1.2.1.52 +xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0034603 +name: pyruvate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah] +xref: EC:1.2.1.51 +xref: MetaCyc:PYRUVATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0004738 ! pyruvate dehydrogenase activity +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034604 +name: pyruvate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah] +xref: EC:1.2.1.51 +xref: MetaCyc:PYRUVATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0034605 +name: cellular response to heat +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] +synonym: "cellular response to heat stress" EXACT [] +is_a: GO:0009408 ! response to heat +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0034606 +name: response to hermaphrodite contact +namespace: biological_process +def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109] +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034607 +name: turning behavior involved in mating +namespace: biological_process +def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109] +synonym: "turning behavior during mating" EXACT [] +is_a: GO:0035178 ! turning behavior +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034608 +name: vulval location +namespace: biological_process +def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467] +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034609 +name: spicule insertion +namespace: biological_process +def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467] +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034610 +name: oligodeoxyribonucleotidase activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah] +synonym: "DNA oligonucleotidase activity" EXACT [] +is_a: GO:0004536 ! deoxyribonuclease activity +is_a: GO:0008946 ! oligonucleotidase activity + +[Term] +id: GO:0034611 +name: oligoribonucleotidase activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah] +synonym: "RNA oligonucleotidase activity" EXACT [] +is_a: GO:0004540 ! ribonuclease activity +is_a: GO:0008946 ! oligonucleotidase activity + +[Term] +id: GO:0034612 +name: response to tumor necrosis factor +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] +synonym: "response to TNF" EXACT [] +is_a: GO:0034097 ! response to cytokine stimulus + +[Term] +id: GO:0034613 +name: cellular protein localization +namespace: biological_process +def: "Any process by which a protein is transported to, and/or maintained in, a specific location within or at the surface of a cell." [GOC:mah] +is_a: GO:0008104 ! protein localization +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0034614 +name: cellular response to reactive oxygen species +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] +subset: gosubset_prok +synonym: "cellular response to active oxygen species" EXACT [] +synonym: "cellular response to AOS" EXACT [] +synonym: "cellular response to reactive oxidative species" EXACT [] +synonym: "cellular response to reactive oxygen intermediate" EXACT [] +synonym: "cellular response to ROI" EXACT [] +synonym: "cellular response to ROS" EXACT [] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:0034615 +name: GCH1 complex +namespace: cellular_component +def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853] +synonym: "GTP cyclohydrolase I complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034616 +name: response to laminar fluid shear stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd] +is_a: GO:0034405 ! response to fluid shear stress + +[Term] +id: GO:0034617 +name: tetrahydrobiopterin binding +namespace: molecular_function +def: "Interacting selectively with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [ChEBI:15372, GOC:mah, GOC:rl] +synonym: "BH4 binding" EXACT [] +synonym: "H4biopterin binding" EXACT [] +synonym: "sapropterin binding" EXACT [] +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0034618 +name: arginine binding +namespace: molecular_function +def: "Interacting selectively with 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:rl] +synonym: "aminopentanoic acid binding" RELATED [] +synonym: "Arg binding" EXACT [] +is_a: GO:0016597 ! amino acid binding + +[Term] +id: GO:0034619 +name: cellular chaperone-mediated protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:mah] +subset: gosubset_prok +synonym: "chaperone activity" RELATED [] +is_a: GO:0043623 ! cellular protein complex assembly +is_a: GO:0051131 ! chaperone-mediated protein complex assembly + +[Term] +id: GO:0034620 +name: cellular response to unfolded protein +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] +comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. +subset: gosubset_prok +synonym: "heat shock protein activity" RELATED [] +is_a: GO:0006986 ! response to unfolded protein +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0034621 +name: cellular macromolecular complex subunit organization +namespace: biological_process +def: "Any process carried out at the cellular level by which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mah, GOC:mtg_mpo] +subset: gosubset_prok +synonym: "cellular macromolecular complex organization" EXACT [] +synonym: "cellular macromolecular complex subunit organisation" EXACT [] +is_a: GO:0043933 ! macromolecular complex subunit organization + +[Term] +id: GO:0034622 +name: cellular macromolecular complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "cellular macromolecule complex assembly" EXACT [] +is_a: GO:0034621 ! cellular macromolecular complex subunit organization +is_a: GO:0065003 ! macromolecular complex assembly + +[Term] +id: GO:0034623 +name: cellular macromolecular complex disassembly +namespace: biological_process +def: "The disaggregation of a macromolecular complex into its constituent components, carried out at the cellular level." [GOC:mah] +subset: gosubset_prok +synonym: "cellular macromolecule complex disassembly" EXACT [] +is_a: GO:0032984 ! macromolecular complex disassembly +is_a: GO:0034621 ! cellular macromolecular complex subunit organization + +[Term] +id: GO:0034624 +name: DNA recombinase assembly involved in gene conversion at mating-type locus +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah] +is_a: GO:0000730 ! DNA recombinase assembly +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0034625 +name: fatty acid elongation, monounsaturated fatty acid +namespace: biological_process +def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid + +[Term] +id: GO:0034626 +name: fatty acid elongation, polyunsaturated fatty acid +namespace: biological_process +def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid + +[Term] +id: GO:0034627 +name: de novo NAD biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604] +is_a: GO:0009435 ! NAD biosynthetic process + +[Term] +id: GO:0034628 +name: de novo NAD biosynthetic process from aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk] +is_a: GO:0034627 ! de novo NAD biosynthetic process + +[Term] +id: GO:0034629 +name: cellular protein complex localization +namespace: biological_process +def: "Any process by which a protein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] +synonym: "establishment and maintenance of cellular protein complex localization" EXACT [] +is_a: GO:0031503 ! protein complex localization +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0034630 +name: RITS complex localization +namespace: biological_process +def: "Any process by which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of RITS complex localization" EXACT [] +is_a: GO:0034629 ! cellular protein complex localization + +[Term] +id: GO:0034631 +name: microtubule anchoring at spindle pole body +namespace: biological_process +def: "Any process by which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116] +synonym: "attachment of spindle microtubules to SPB" EXACT [] +synonym: "attachment of spindle microtubules to spindle pole body" EXACT [] +synonym: "microtubule anchoring at SPB" EXACT [] +is_a: GO:0034453 ! microtubule anchoring + +[Term] +id: GO:0034632 +name: retinol transporter activity +namespace: molecular_function +def: "Enables the directed movement of retinol into, out of, within or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:mah, GOC:vk] +synonym: "vitamin A1 transporter activity" EXACT [] +is_a: GO:0051183 ! vitamin transporter activity + +[Term] +id: GO:0034633 +name: retinol transport +namespace: biological_process +def: "The directed movement of retinol into, out of, within or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:mah, GOC:vk] +synonym: "vitamin A1 transport" EXACT [] +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0034634 +name: glutathione transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of glutathione, the tripeptide glutamylcysteinylglycine, across a membrane into, out of, within or between cells." [GOC:mah] +is_a: GO:0022891 ! substrate-specific transmembrane transporter activity + +[Term] +id: GO:0034635 +name: glutathione transport +namespace: biological_process +def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of, within or between cells." [GOC:mah] +is_a: GO:0042939 ! tripeptide transport + +[Term] +id: GO:0034636 +name: strand invasion involved in gene conversion at mating-type locus +namespace: biological_process +def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA at the mating-type locus. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This process occurs as part of gene conversion at the mating-type locus." [GOC:mah] +xref: Reactome:76004 +is_a: GO:0042148 ! strand invasion +relationship: part_of GO:0007534 ! gene conversion at mating-type locus + +[Term] +id: GO:0034637 +name: cellular carbohydrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah] +is_a: GO:0016051 ! carbohydrate biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0034638 +name: phosphatidylcholine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp] +subset: gosubset_prok +synonym: "phosphatidylcholine breakdown" EXACT [] +synonym: "phosphatidylcholine catabolism" EXACT [] +synonym: "phosphatidylcholine degradation" EXACT [] +is_a: GO:0046470 ! phosphatidylcholine metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0034639 +name: L-amino acid efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] +synonym: "L-amino acid efflux permease activity" EXACT [] +synonym: "L-amino acid export transporter activity" EXACT [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0034640 +name: mitochondrion localization by microtubule attachment +namespace: biological_process +def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644] +synonym: "mitochondrial localization by microtubule attachment" EXACT [] +synonym: "mitochondrial migration by microtubule attachment" EXACT [] +synonym: "mitochondrion migration by microtubule attachment" EXACT [] +is_a: GO:0034643 ! mitochondrion localization, microtubule-mediated + +[Term] +id: GO:0034641 +name: cellular nitrogen compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] +subset: gosubset_prok +synonym: "cellular nitrogen compound metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0034642 +name: mitochondrial migration along actin filament +namespace: biological_process +def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220] +synonym: "mitochondrial migration along microfilament" EXACT [] +synonym: "mitochondrial migration, actin-mediated" EXACT [] +synonym: "mitochondrion migration along microfilament" EXACT [] +synonym: "mitochondrion transport along actin filament" EXACT [] +is_a: GO:0030048 ! actin filament-based movement +is_a: GO:0051654 ! establishment of mitochondrion localization + +[Term] +id: GO:0034643 +name: mitochondrion localization, microtubule-mediated +namespace: biological_process +def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] +synonym: "microtubule-mediated mitochondrion localization" EXACT [] +synonym: "mitochondrial localization, microtubule-mediated" EXACT [] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0051654 ! establishment of mitochondrion localization + +[Term] +id: GO:0034644 +name: cellular response to UV +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] +subset: gosubset_prok +synonym: "cellular response to ultraviolet light stimulus" EXACT [] +synonym: "cellular response to ultraviolet radiation stimulus" EXACT [] +synonym: "cellular response to UV light stimulus" EXACT [] +synonym: "cellular response to UV radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0034645 +name: cellular macromolecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0034646 +name: organelle-enclosing lipid monolayer +namespace: cellular_component +def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah] +is_a: GO:0044446 ! intracellular organelle part + +[Term] +id: GO:0034647 +name: histone demethylase activity (H3-trimethyl-K4 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] +synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT [] +is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) + +[Term] +id: GO:0034648 +name: histone demethylase activity (H3-dimethyl-K4 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] +synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT [] +is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) + +[Term] +id: GO:0034649 +name: histone demethylase activity (H3-monomethyl-K4 specific) +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] +synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT [] +is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific) + +[Term] +id: GO:0034650 +name: cortisol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [ChEBI:17650, GOC:mah, GOC:rl] +synonym: "cortisol metabolism" EXACT [] +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0034651 +name: cortisol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [ChEBI:17650, GOC:mah, GOC:rl] +synonym: "cortisol anabolism" NARROW [] +synonym: "cortisol biosynthesis" EXACT [] +synonym: "cortisol formation" EXACT [] +synonym: "cortisol synthesis" EXACT [] +is_a: GO:0006700 ! C21-steroid hormone biosynthetic process +is_a: GO:0006704 ! glucocorticoid biosynthetic process +is_a: GO:0034650 ! cortisol metabolic process + +[Term] +id: GO:0034652 +name: extrachromosomal circular DNA localization during cell aging +namespace: biological_process +def: "Any process by which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells as they age." [GOC:jp, PMID:18660802] +comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. +synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT [] +is_a: GO:0001301 ! progressive alteration of chromatin during cell aging + +[Term] +id: GO:0034653 +name: retinoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:mah] +synonym: "retinoic acid breakdown" EXACT [] +synonym: "retinoic acid catabolism" EXACT [] +synonym: "retinoic acid degradation" EXACT [] +synonym: "vitamin A1 acid catabolic process" EXACT [] +is_a: GO:0042363 ! fat-soluble vitamin catabolic process +is_a: GO:0042573 ! retinoic acid metabolic process + +[Term] +id: GO:0034654 +name: nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] +subset: gosubset_prok +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0034655 +name: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] +subset: gosubset_prok +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0034656 +name: nucleobase, nucleoside and nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides." [GOC:mah] +synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT [] +is_a: GO:0034655 ! nucleobase, nucleoside, nucleotide and nucleic acid catabolic process +is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process + +[Term] +id: GO:0034657 +name: GID complex +namespace: cellular_component +def: "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p." [PMID:12686616, PMID:18508925] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034658 +name: isopropylmalate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of isopropylmalate from one side of the membrane to the other." [GOC:mah] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0034659 +name: isopropylmalate transport +namespace: biological_process +def: "The directed movement of isopropylmalate into, out of, within or between cells." [GOC:mah] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0034660 +name: ncRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah] +subset: gosubset_prok +synonym: "ncRNA metabolism" EXACT [] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0034661 +name: ncRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable trascripts (CUTs)." [GOC:rb, PMID:18591258] +synonym: "ncRNA breakdown" EXACT [] +synonym: "ncRNA catabolism" EXACT [] +synonym: "ncRNA degradation" EXACT [] +is_a: GO:0006401 ! RNA catabolic process +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034662 +name: CFTR-NHERF-ezrin complex +namespace: cellular_component +def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:016926444, PMID:16129695, PMID:16798722] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0034663 +name: endoplasmic reticulum chaperone complex +namespace: cellular_component +def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] +synonym: "endoplasmic reticulum network complex" RELATED [] +synonym: "ER chaperone complex" EXACT [] +synonym: "ER network complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0034664 +name: Ig heavy chain-bound endoplasmic reticulum chaperone complex +namespace: cellular_component +def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] +synonym: "Ig heavy chain-bound ER chaperone complex" EXACT [] +synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0034665 +name: alpha1-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA1-ITGB1 complex" NARROW [] +synonym: "VLA-1 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034666 +name: alpha2-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA2-ITGB1 complex" NARROW [] +synonym: "VLA-2 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034667 +name: alpha3-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA3-ITGB1 complex" NARROW [] +synonym: "VLA-3 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034668 +name: alpha4-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA4-ITGB1 complex" NARROW [] +synonym: "VLA-4 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034669 +name: alpha4-beta7 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042] +synonym: "ITGA4-ITGB7 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034670 +name: chemotaxis to arachidonic acid +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0034671 +name: retinoic acid receptor signaling pathway involved in pronephros anterior-posterior patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0034672 ! pronephros anterior/posterior patterning + +[Term] +id: GO:0034672 +name: pronephros anterior/posterior patterning +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the pronephros." [GOC:mah] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0034673 +name: inhibin-betaglycan-ActRII complex +namespace: cellular_component +def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [PMID:10746731] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0034674 +name: alpha5-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA5-ITGB1 complex" NARROW [] +synonym: "VLA-5 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034675 +name: alpha6-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA6-ITGB1 complex" NARROW [] +synonym: "VLA-6 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034676 +name: alpha6-beta4 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA6-ITGB4 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034677 +name: alpha7-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA7-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034678 +name: alpha8-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA8-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034679 +name: alpha9-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA9-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034680 +name: alpha10-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA10-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034681 +name: alpha11-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA11-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034682 +name: alphav-beta1 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGAV-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034683 +name: alphav-beta3 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042] +synonym: "ITGAV-ITGB3 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034684 +name: alphav-beta5 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042] +synonym: "ITGAV-ITGB5 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034685 +name: alphav-beta6 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042] +synonym: "ITGAV-ITGB6 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034686 +name: alphav-beta8 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042] +synonym: "ITGAV-ITGB8 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034687 +name: alphaL-beta2 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042] +synonym: "Itgal-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034688 +name: alphaM-beta2 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042] +synonym: "Itgam-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034689 +name: alphaX-beta2 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042] +synonym: "Itgax-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034690 +name: alphaD-beta2 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042] +synonym: "Itgad-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034691 +name: alphaE-beta7 integrin complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042] +synonym: "Itgae-Itgb7 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034692 +name: E.F.G complex +namespace: cellular_component +def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0034693 +name: snRNP U11/U12 +namespace: cellular_component +def: "A ribonucleoprotein complex containing two small nuclear ribonucleoproteins, snRNP U11 and snRNP U12." [GOC:mah, PMID:15146077] +synonym: "18S U11/U12 snRNP" NARROW [] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex +relationship: part_of GO:0005689 ! U12-dependent spliceosome + +[Term] +id: GO:0034694 +name: response to prostaglandin stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:vk] +is_a: GO:0009725 ! response to hormone stimulus +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0034695 +name: response to prostaglandin E stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:vk] +is_a: GO:0034694 ! response to prostaglandin stimulus + +[Term] +id: GO:0034696 +name: response to prostaglandin F stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:vk] +is_a: GO:0034694 ! response to prostaglandin stimulus + +[Term] +id: GO:0034697 +name: response to prostaglandin I stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:vk] +is_a: GO:0034694 ! response to prostaglandin stimulus + +[Term] +id: GO:0034698 +name: response to gonadotropin stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:vk] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0034699 +name: response to luteinizing hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:vk] +is_a: GO:0034698 ! response to gonadotropin stimulus + +[Term] +id: GO:0034700 +name: allulose 6-phosphate 3-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk] +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0034701 +name: tripeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah] +xref: EC:3.4.13 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0034702 +name: ion channel complex +namespace: cellular_component +def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016021 ! integral to membrane + +[Term] +id: GO:0034703 +name: cation channel complex +namespace: cellular_component +def: "An ion channel complex through which cations pass." [GOC:mah] +is_a: GO:0034702 ! ion channel complex + +[Term] +id: GO:0034704 +name: calcium channel complex +namespace: cellular_component +def: "An ion channel complex through which calcium ions pass." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0034705 +name: potassium channel complex +namespace: cellular_component +def: "An ion channel complex through which potassium ions pass." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0034706 +name: sodium channel complex +namespace: cellular_component +def: "An ion channel complex through which sodium ions pass." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0034707 +name: chloride channel complex +namespace: cellular_component +def: "An ion channel complex through which chloride ions pass." [GOC:mah] +is_a: GO:0034702 ! ion channel complex + +[Term] +id: GO:0034708 +name: methyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses methyltransferase activity." [GOC:mah] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034709 +name: methylosome +namespace: cellular_component +def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] +synonym: "20S methylosome" EXACT [] +synonym: "20S methyltransferase complex" EXACT [] +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034710 +name: inhibin complex binding +namespace: molecular_function +def: "Interacting selectively with an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:mah] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0034711 +name: inhibin binding +namespace: molecular_function +def: "Interacting selectively with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:mah] +synonym: "inhibin monomer binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0034712 +name: inhibin alpha binding +namespace: molecular_function +def: "Interacting selectively with inhibin alpha." [GOC:mah] +is_a: GO:0034711 ! inhibin binding + +[Term] +id: GO:0034713 +name: type I transforming growth factor beta receptor binding +namespace: molecular_function +alt_id: GO:0005103 +alt_id: GO:0005116 +alt_id: GO:0005120 +def: "Interacting selectively with a type I transforming growth factor beta receptor." [GOC:mah] +synonym: "babo binding" NARROW [] +synonym: "babo ligand" NARROW [] +synonym: "baboon binding" NARROW [] +synonym: "baboon ligand" NARROW [] +synonym: "baboon receptor ligand" NARROW [] +synonym: "sax binding" NARROW [] +synonym: "sax ligand" NARROW [] +synonym: "saxophone binding" NARROW [] +synonym: "saxophone ligand" NARROW [] +synonym: "TGF-beta type I binding" EXACT [] +synonym: "thickveins binding" NARROW [] +synonym: "thickveins ligand" NARROW [] +synonym: "tkv binding" NARROW [] +synonym: "tkv ligand" NARROW [] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "transforming growth factor beta receptor type I binding" EXACT [] +synonym: "type I TGF-beta binding" EXACT [] +is_a: GO:0005160 ! transforming growth factor beta receptor binding + +[Term] +id: GO:0034714 +name: type III transforming growth factor beta receptor binding +namespace: molecular_function +def: "Interacting selectively with a type III transforming growth factor beta receptor." [GOC:mah] +synonym: "betaglycan binding" RELATED [] +synonym: "TGF-beta type III binding" EXACT [] +synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] +synonym: "transforming growth factor beta receptor type III binding" EXACT [] +synonym: "type IIII TGF-beta binding" EXACT [] +is_a: GO:0005160 ! transforming growth factor beta receptor binding + +[Term] +id: GO:0034715 +name: pICln-Sm protein complex +namespace: cellular_component +def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] +synonym: "6S pICln complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034716 +name: Gemin3-Gemin4-Gemin5 complex +namespace: cellular_component +def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034717 +name: Gemin6-Gemin7-unrip complex +namespace: cellular_component +def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034718 +name: SMN-Gemin2 complex +namespace: cellular_component +def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034719 +name: SMN-Sm protein complex +namespace: cellular_component +def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [PMID:11522829, PMID:17401408] +comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797. +synonym: "SMN-containing protein complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034720 +name: histone H3-K4 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah] +synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED [] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0034721 +name: histone H3-K4 demethylation, trimethyl-H3-K4-specific +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah] +synonym: "H3K4 demethylation (me3)" EXACT [] +synonym: "histone H3-K4 tridemethylation" RELATED [] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0034722 +name: gamma-glutamyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26] +subset: gosubset_prok +synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] +xref: EC:3.4.19.9 +is_a: GO:0008242 ! omega peptidase activity + +[Term] +id: GO:0034723 +name: DNA replication-dependent nucleosome organization +namespace: biological_process +def: "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] +synonym: "DNA replication-dependent nucleosome organisation" EXACT [] +is_a: GO:0006333 ! chromatin assembly or disassembly +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0034724 +name: DNA replication-independent nucleosome organization +namespace: biological_process +def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629] +synonym: "DNA replication-independent nucleosome organisation" EXACT [] +is_a: GO:0006333 ! chromatin assembly or disassembly +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0034725 +name: DNA replication-dependent nucleosome disassembly +namespace: biological_process +def: "The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] +is_a: GO:0006337 ! nucleosome disassembly +is_a: GO:0034723 ! DNA replication-dependent nucleosome organization + +[Term] +id: GO:0034726 +name: DNA replication-independent nucleosome disassembly +namespace: biological_process +def: "The controlled breakdown of nucleosomes outside the context of DNA replication." [GOC:mah, PMID:17510629] +is_a: GO:0006337 ! nucleosome disassembly +is_a: GO:0034724 ! DNA replication-independent nucleosome organization + +[Term] +id: GO:0034727 +name: piecemeal microautophagy of nucleus +namespace: biological_process +def: "Degradation of a cell nucleus by microautophagy." [GOC:jp, PMID:18701704] +synonym: "PMN" EXACT [] +is_a: GO:0000422 ! mitochondrion degradation +is_a: GO:0016237 ! microautophagy + +[Term] +id: GO:0034728 +name: nucleosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah] +synonym: "nucleosome organisation" EXACT [] +is_a: GO:0006325 ! establishment or maintenance of chromatin architecture + +[Term] +id: GO:0034729 +name: histone H3-K79 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se] +synonym: "histone H3 K79 methylation" EXACT [] +synonym: "histone H3K79me" EXACT [] +synonym: "histone lysine H3 K79 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0034730 +name: SmD-containing SMN-Sm protein complex +namespace: cellular_component +def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408] +synonym: "SMN-containing protein complex" BROAD [] +is_a: GO:0034719 ! SMN-Sm protein complex + +[Term] +id: GO:0034731 +name: Lsm-containing SMN-Sm protein complex +namespace: cellular_component +def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408] +synonym: "SMN-containing protein complex" BROAD [] +is_a: GO:0034719 ! SMN-Sm protein complex + +[Term] +id: GO:0034732 +name: transcription factor TFIIIB-alpha complex +namespace: cellular_component +def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012] +is_a: GO:0000126 ! transcription factor TFIIIB complex + +[Term] +id: GO:0034733 +name: transcription factor TFIIIB-beta complex +namespace: cellular_component +def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012] +comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans. +is_a: GO:0000126 ! transcription factor TFIIIB complex + +[Term] +id: GO:0034734 +name: transcription factor TFIIIC1 complex +namespace: cellular_component +def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0000127 ! transcription factor TFIIIC complex + +[Term] +id: GO:0034735 +name: transcription factor TFIIIC2 complex +namespace: cellular_component +def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0000127 ! transcription factor TFIIIC complex + +[Term] +id: GO:0034736 +name: cholesterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + cholesterol = CoA + cholesterol ester." [EC:2.3.1.26] +synonym: "ACAT activity" BROAD [EC:2.3.1.26] +synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" EXACT [EC:2.3.1.26] +synonym: "acyl-CoA:cholesterol acyltransferase activity" EXACT [EC:2.3.1.26] +synonym: "acyl-CoA:cholesterol O-acyltransferase activity" EXACT [EC:2.3.1.26] +synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT [] +synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26] +synonym: "cholesterol ester synthetase activity" EXACT [EC:2.3.1.26] +synonym: "cholesterol O-acyltransferase activity" EXACT [] +synonym: "cholesteryl ester synthetase activity" EXACT [EC:2.3.1.26] +xref: EC:2.3.1.26 +xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN +is_a: GO:0004772 ! sterol O-acyltransferase activity + +[Term] +id: GO:0034737 +name: ergosterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah] +xref: EC:2.3.1.26 +xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN +is_a: GO:0004772 ! sterol O-acyltransferase activity + +[Term] +id: GO:0034738 +name: lanosterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah] +xref: EC:2.3.1.26 +xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN +is_a: GO:0004772 ! sterol O-acyltransferase activity + +[Term] +id: GO:0034739 +name: histone deacetylase activity (H3-K16 specific) +namespace: molecular_function +def: "Catalysis of the removal of an acetyl group from lysine at position 16 of the histone H3 protein." [GOC:mah] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0034740 +name: TFIIIC-TOP1-SUB1 complex +namespace: cellular_component +def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958] +synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT [] +is_a: GO:0005667 ! transcription factor complex +relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme + +[Term] +id: GO:0034741 +name: APC-tubulin-IQGAP1 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "60S APC complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034742 +name: APC-Axin-1-beta-catenin complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, and beta-catenin." [PMID:16188939] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "23S APC complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034743 +name: APC-IQGAP complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034744 +name: APC-IQGAP1-Cdc42 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034745 +name: APC-IQGAP1-Rac1 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034746 +name: APC-IQGAP1-CLIP-170 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034747 +name: Axin-APC-beta-catenin-GSK3B complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, beta-catenin, and glycogen synthase kinase 3 beta. Formation of this complex leads to phosphorylation of beta-catenin and down-regulation of beta-catenin activity." [PMID:9601641] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034748 +name: Par3-APC-KIF3A complex +namespace: cellular_component +def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034749 +name: Scrib-APC complex +namespace: cellular_component +def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "hScrib-APC complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034750 +name: Scrib-APC-beta-catenin complex +namespace: cellular_component +def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "hScrib-APC-beta-catenin complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034751 +name: aryl hydrocarbon receptor complex +namespace: cellular_component +def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497] +synonym: "AhR complex" EXACT [] +synonym: "AHRC" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034752 +name: cytosolic aryl hydrocarbon receptor complex +namespace: cellular_component +def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995] +synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED [] +synonym: "cytosolic AhR complex" EXACT [] +synonym: "cytosolic AHRC" EXACT [] +is_a: GO:0034751 ! aryl hydrocarbon receptor complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0034753 +name: nuclear aryl hydrocarbon receptor complex +namespace: cellular_component +def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497] +synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED [] +synonym: "nuclear AhR complex" EXACT [] +synonym: "nuclear AHRC" EXACT [] +is_a: GO:0034751 ! aryl hydrocarbon receptor complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0034754 +name: cellular hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells." [GOC:mah] +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0034755 +name: transmembrane iron ion transport +namespace: biological_process +def: "A process whereby an iron ion is transported from one side of a membrane to the other." [GOC:mah] +subset: gosubset_prok +synonym: "transmembrane iron transport" EXACT [] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0034756 +name: regulation of iron ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of, within or between cells." [GOC:mah] +synonym: "regulation of Fe transport" EXACT [] +synonym: "regulation of iron transport" EXACT [] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0006826 ! iron ion transport + +[Term] +id: GO:0034757 +name: negative regulation of iron ion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of iron ions into, out of, within or between cells." [GOC:mah] +synonym: "down regulation of iron ion transport" EXACT [] +synonym: "down-regulation of iron ion transport" EXACT [] +synonym: "downregulation of iron ion transport" EXACT [] +synonym: "inhibition of iron ion transport" NARROW [] +synonym: "negative regulation of iron transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0006826 ! iron ion transport + +[Term] +id: GO:0034758 +name: positive regulation of iron ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of, within or between cells." [GOC:mah] +synonym: "activation of iron ion transport" NARROW [] +synonym: "positive regulation of iron transport" EXACT [] +synonym: "stimulation of iron ion transport" NARROW [] +synonym: "up regulation of iron ion transport" EXACT [] +synonym: "up-regulation of iron ion transport" EXACT [] +synonym: "upregulation of iron ion transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0006826 ! iron ion transport + +[Term] +id: GO:0034759 +name: regulation of transmembrane iron ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other." [GOC:mah] +synonym: "regulation of transmembrane Fe transport" EXACT [] +synonym: "regulation of transmembrane iron transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:0034765 ! regulation of transmembrane ion transport +relationship: regulates GO:0034755 ! transmembrane iron ion transport + +[Term] +id: GO:0034760 +name: negative regulation of transmembrane iron ion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other." [GOC:mah] +synonym: "down regulation of transmembrane iron ion transport" EXACT [] +synonym: "down-regulation of transmembrane iron ion transport" EXACT [] +synonym: "downregulation of transmembrane iron ion transport" EXACT [] +synonym: "inhibition of transmembrane iron ion transport" NARROW [] +synonym: "negative regulation of transmembrane iron transport" EXACT [] +is_a: GO:0034757 ! negative regulation of iron ion transport +is_a: GO:0034759 ! regulation of transmembrane iron ion transport +is_a: GO:0034766 ! negative regulation of transmembrane ion transport +relationship: negatively_regulates GO:0034755 ! transmembrane iron ion transport + +[Term] +id: GO:0034761 +name: positive regulation of transmembrane iron ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other." [GOC:mah] +synonym: "activation of transmembrane iron ion transport" NARROW [] +synonym: "positive regulation of transmembrane iron transport" EXACT [] +synonym: "stimulation of transmembrane iron ion transport" NARROW [] +synonym: "up regulation of transmembrane iron ion transport" EXACT [] +synonym: "up-regulation of transmembrane iron ion transport" EXACT [] +synonym: "upregulation of transmembrane iron ion transport" EXACT [] +is_a: GO:0034758 ! positive regulation of iron ion transport +is_a: GO:0034759 ! regulation of transmembrane iron ion transport +is_a: GO:0034767 ! positive regulation of transmembrane ion transport +relationship: positively_regulates GO:0034755 ! transmembrane iron ion transport + +[Term] +id: GO:0034762 +name: regulation of transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034763 +name: negative regulation of transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] +synonym: "down regulation of transmembrane transport" EXACT [] +synonym: "down-regulation of transmembrane transport" EXACT [] +synonym: "downregulation of transmembrane transport" EXACT [] +synonym: "inhibition of transmembrane transport" NARROW [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034764 +name: positive regulation of transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] +synonym: "activation of transmembrane transport" NARROW [] +synonym: "positive regulation of transmembrane transport" EXACT [] +synonym: "stimulation of transmembrane transport" NARROW [] +synonym: "up regulation of transmembrane transport" EXACT [] +synonym: "up-regulation of transmembrane transport" EXACT [] +synonym: "upregulation of transmembrane transport" EXACT [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034765 +name: regulation of transmembrane ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0034766 +name: negative regulation of transmembrane ion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "down regulation of transmembrane ion transport" EXACT [] +synonym: "down-regulation of transmembrane ion transport" EXACT [] +synonym: "downregulation of transmembrane ion transport" EXACT [] +synonym: "inhibition of transmembrane ion transport" NARROW [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0034765 ! regulation of transmembrane ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0034767 +name: positive regulation of transmembrane ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "activation of transmembrane ion transport" NARROW [] +synonym: "positive regulation of transmembrane ion transport" EXACT [] +synonym: "stimulation of transmembrane ion transport" NARROW [] +synonym: "up regulation of transmembrane ion transport" EXACT [] +synonym: "up-regulation of transmembrane ion transport" EXACT [] +synonym: "upregulation of transmembrane ion transport" EXACT [] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0034765 ! regulation of transmembrane ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0034768 +name: (E)-beta-ocimene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [PMID:12624761] +xref: EC:4.2.3.15 +xref: MetaCyc:RXN-5110 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034769 +name: basement membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] +is_a: GO:0022411 ! cellular component disassembly + +[Term] +id: GO:0034770 +name: histone H3-K20 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H3 K20 methylation" EXACT [] +synonym: "histone H3K20me" EXACT [] +synonym: "histone lysine H3 K20 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0034771 +name: histone H3-K20 monomethylation +namespace: biological_process +def: "The modification of histone H3 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H3 K20 monomethylation" EXACT [] +synonym: "histone lysine H3 K20 monomethylation" EXACT [] +is_a: GO:0018026 ! peptidyl-lysine monomethylation +is_a: GO:0034770 ! histone H3-K20 methylation + +[Term] +id: GO:0034772 +name: histone H3-K20 dimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H3 K20 dimethylation" EXACT [] +synonym: "histone lysine H3 K20 dimethylation" EXACT [] +is_a: GO:0018027 ! peptidyl-lysine dimethylation +is_a: GO:0034770 ! histone H3-K20 methylation + +[Term] +id: GO:0034773 +name: histone H3-K20 trimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H3 K20 trimethylation" EXACT [] +synonym: "histone lysine H3 K20 trimethylation" EXACT [] +is_a: GO:0018023 ! peptidyl-lysine trimethylation +is_a: GO:0034770 ! histone H3-K20 methylation + +[Term] +id: GO:0034774 +name: secretory granule lumen +namespace: cellular_component +def: ": The volume enclosed by the membrane of a secretory granule." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0030141 ! secretory granule + +[Term] +id: GO:0034775 +name: transmembrane glutathione transport +namespace: biological_process +def: "A process whereby glutathinone is transported from one side of a membrane to the other." [GOC:mah] +is_a: GO:0034635 ! glutathione transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034776 +name: response to histamine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [ChEBI:18295, GOC:mah, GOC:vk] +synonym: "response to histamine stimulus" EXACT [] +is_a: GO:0014075 ! response to amine stimulus + +[Term] +id: GO:0034777 +name: recycling endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph] +is_a: GO:0031904 ! endosome lumen +relationship: part_of GO:0055037 ! recycling endosome + +[Term] +id: GO:0034778 +name: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1003] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0636 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034779 +name: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [UM-BBD_reactionID:r1004] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0637 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034780 +name: glyphosate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid (AMPA) + H+ + 2 e-." [UM-BBD_reactionID:r0073] +xref: EC:1.5.-.- +xref: UM-BBD_enzymeID:e0639 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034781 +name: N-cyclohexylformamide amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [UM-BBD_reactionID:r1030] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0640 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034782 +name: dimethylmalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [UM-BBD_reactionID:r1031] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0641 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034783 +name: pivalate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [UM-BBD_reactionID:r1032] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0642 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034784 +name: pivalyl-CoA mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA." [UM-BBD_reactionID:r1033] +xref: EC:5.4.99.- +xref: UM-BBD_enzymeID:e0643 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0034785 +name: salicylate 5-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0644 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034786 +name: 9-fluorenone-3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-Hydro-1,1a-dihydroxy-9-fluorenone." [UM-BBD_reactionID:r1039] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0645 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034787 +name: 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [UM-BBD_reactionID:r1040] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0646 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034788 +name: 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [UM-BBD_reactionID:r1041] +xref: EC:1.13.-.- +xref: UM-BBD_enzymeID:e0647 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034789 +name: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [UM-BBD_reactionID:r1042] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0648 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034790 +name: 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1043] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0649 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034791 +name: isobutylamine N-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine+ NADP+ + H2O." [UM-BBD_reactionID:r1053] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0656 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034792 +name: hypophosphite dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [UM-BBD_reactionID:r1058] +xref: EC:1.14.11.- +xref: UM-BBD_enzymeID:e0657 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0034793 +name: cyclopropanecarboxylate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [UM-BBD_reactionID:r1056] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0659 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034794 +name: cyclopropanecarboxyl-CoA decyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057] +xref: EC:5.5.1.- +xref: UM-BBD_enzymeID:e0660 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0034795 +name: butane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059] +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0661 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034796 +name: adipate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [UM-BBD_reactionID:r1060] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0662 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034797 +name: fosfomycin 2-glutathione ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1073] +xref: EC:6.2.-.- +xref: UM-BBD_enzymeID:e0665 +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0034798 +name: fosfomycin 2-L-cysteine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1- L-cysteine-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1074] +xref: EC:6.2.-.- +xref: UM-BBD_enzymeID:e0666 +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0034799 +name: dihydride TNP tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [UM-BBD_reactionID:r1070] +xref: EC:5.3.2.- +xref: UM-BBD_enzymeID:e0669 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0034800 +name: TNP dihydride denitratase activity +namespace: molecular_function +def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = 2,4-DNP hydride Meisenheimer complex + NO2." [UM-BBD_reactionID:r1067] +xref: EC:1.7.99.- +xref: UM-BBD_enzymeID:e0670 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0034801 +name: 2,4-dinitrocyclohexanone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [UM-BBD_reactionID:r1069] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0671 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034802 +name: branched-chain dodecylbenzene sulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + (SO3)2-." [UM-BBD_reactionID:r1079] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0672 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034803 +name: 3-hydroxy-2-naphthoate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0678 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034804 +name: benzo(a)pyrene 11,12-epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [UM-BBD_reactionID:r1119] +xref: EC:1.14.99.- +xref: UM-BBD_enzymeID:e0688 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034805 +name: benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1121] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0689 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034806 +name: benzo(a)pyrene 11,12-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0692 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034807 +name: 4,5-dihydroxybenzo(a)pyrene methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [UM-BBD_reactionID:r1131] +xref: EC:2.1.1.- +xref: UM-BBD_enzymeID:e0694 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034808 +name: benzo(a)pyrene 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0695 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034809 +name: benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [UM-BBD_reactionID:r1127] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0696 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034810 +name: 4,5-dihydroxybenzo(a)pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0697 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034811 +name: benzo(a)pyrene 9,10-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0700 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034812 +name: 9,10-dihydroxybenzo(a)pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0702 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034813 +name: benzo(a)pyrene 7,8-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0703 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034814 +name: 7,8-dihydroxy benzo(a)pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0704 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034815 +name: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-Oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135] +xref: EC:4.1.3.- +xref: UM-BBD_enzymeID:e0706 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0034816 +name: anthracene 9,10-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [UM-BBD_reactionID:r1141] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0707 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034817 +name: cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [UM-BBD_reactionID:r1144] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0708 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034818 +name: ADD 9alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149] +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0713 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034819 +name: 3-HSA hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0714 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034820 +name: 4,9-DSHA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3E,1Z)-4,5-9,10-Diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [UM-BBD_reactionID:r1152] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0716 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034821 +name: citronellol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [UM-BBD_reactionID:r1155] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0717 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034822 +name: citronellal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [UM-BBD_reactionID:r1156] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0718 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034823 +name: citronellyl-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0719 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034824 +name: citronellyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellyl-CoA + NAH+ = cis-geranyl-CoA + NADH + H+." [UM-BBD_reactionID:r1159] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0720 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034825 +name: tetralin ring-hydroxylating dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0727 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034826 +name: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [UM-BBD_reactionID:r1170] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0728 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034827 +name: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0729 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034828 +name: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [UM-BBD_reactionID:r1172] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0730 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034829 +name: 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [UM-BBD_reactionID:r1172] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0731 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034830 +name: (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174] +xref: EC:4.1.3.- +xref: UM-BBD_enzymeID:e0732 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0034831 +name: (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1176] +xref: EC:1.1.1.- +xref: UM-BBD_enzymeID:e0733 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034832 +name: geranial dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+." [UM-BBD_reactionID:r1164] +xref: EC:1.2.1.- +xref: UM-BBD_enzymeID:e0735 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034833 +name: geranylate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [UM-BBD_reactionID:r1165] +xref: EC:2.8.3.- +xref: UM-BBD_enzymeID:e0736 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0034834 +name: 2-mercaptobenzothiazole dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol ." [UM-BBD_reactionID:r1177] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0737 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034835 +name: 2-mercaptobenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178] +xref: EC:1.13.12.- +xref: UM-BBD_enzymeID:e0738 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034836 +name: 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181] +xref: EC:1.13.12.- +xref: UM-BBD_enzymeID:e0739 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034837 +name: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [UM-BBD_reactionID:r1179] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0740 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034838 +name: menthone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [UM-BBD_reactionID:r1183] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0742 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034839 +name: menth-2-enone hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [UM-BBD_reactionID:r1184] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0743 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034840 +name: 3-hydroxymenthone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [UM-BBD_reactionID:r1185] +xref: EC:1.1.1.- +xref: UM-BBD_enzymeID:e0744 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034841 +name: mentha-1,3-dione-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [UM-BBD_reactionID:r1186] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0745 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034842 +name: thiophene-2-carboxylate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA - AMP + PPi." [UM-BBD_reactionID:r1234] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0774 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034843 +name: 2-oxoglutaryl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [UM-BBD_reactionID:r1238] +xref: EC:3.1.2.- +xref: UM-BBD_enzymeID:e0778 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0034844 +name: naphthyl-2-methyl-succinate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [UM-BBD_reactionID:r1256] +xref: EC:2.8.3.- +xref: UM-BBD_enzymeID:e0784 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0034845 +name: naphthyl-2-methyl-succinyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258] +xref: EC:1.3.99.- +xref: UM-BBD_enzymeID:e0785 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034846 +name: naphthyl-2-methylene-succinyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [UM-BBD_reactionID:r1259] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0786 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034847 +name: naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1260] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0787 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034848 +name: naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [UM-BBD_reactionID:r1261] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0788 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0034849 +name: 2-naphthoate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [UM-BBD_reactionID:r1262] +xref: EC:2.8.3.- +xref: UM-BBD_enzymeID:e0789 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0034850 +name: isooctane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269] +xref: EC:1.13.12.- +xref: UM-BBD_enzymeID:e0795 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034851 +name: 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r1274] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0800 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0034852 +name: 4,4-dimethyl-3-oxopentanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1309] +xref: EC:1.2.-.- +xref: UM-BBD_enzymeID:e0801 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0034853 +name: 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [UM-BBD_reactionID:r1278] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0804 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034854 +name: 4,4-dimethyl-3-oxopentanoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [UM-BBD_reactionID:r1280] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0806 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034855 +name: 4-AD 9alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153] +xref: EC:1.14.15.- +xref: UM-BBD_enzymeID:e0807 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034856 +name: 2-hydroxyhexa-2,4-dienoate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0809 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034857 +name: 2-(methylthio)benzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [UM-BBD_reactionID:r1287] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0810 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034858 +name: 2-hydroxybenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [UM-BBD_reactionID:r1291] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0811 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034859 +name: benzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [UM-BBD_reactionID:r1292] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0812 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034860 +name: 2-mercaptobenzothiazole desulfurase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + H2S + oxidized acceptor." [UM-BBD_reactionID:r1288] +xref: EC:4.4.1.- +xref: UM-BBD_enzymeID:e0813 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0034861 +name: benzothiazole-2-sulfonate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + SO3H-." [UM-BBD_reactionID:r1290] +xref: EC:3.13.1.- +xref: UM-BBD_enzymeID:e0814 +is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds + +[Term] +id: GO:0034862 +name: 2,6-dihydroxybenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [UM-BBD_reactionID:r1294] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0815 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034863 +name: 2,4,4-trimethyl-1-pentanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal+ 2 H+ + 2 e-." [UM-BBD_reactionID:r1270] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0816 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034864 +name: 2,4,4-trimethylpentanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1275] +xref: EC:1.2.-.- +xref: UM-BBD_enzymeID:e0817 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0034865 +name: 2,4,4-trimethylpentanoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [UM-BBD_reactionID:r1271] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0818 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034866 +name: 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2e-." [UM-BBD_reactionID:r1276] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0819 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034867 +name: 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [UM-BBD_reactionID:r1277] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0820 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034868 +name: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e- ." [UM-BBD_reactionID:r1273] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0821 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034869 +name: 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [UM-BBD_reactionID:r1307] +xref: EC:3.1.2.- +xref: UM-BBD_enzymeID:e0822 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0034870 +name: pinacolone 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [UM-BBD_reactionID:r12979] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0823 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034871 +name: 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1308] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0824 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034872 +name: trans-geranyl-CoA isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310] +xref: EC:5.2.1.- +xref: UM-BBD_enzymeID:e0825 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0034873 +name: thioacetamide S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thioacetamide +O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [UM-BBD_reactionID:r1312] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0826 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034874 +name: thioacetamide S-oxide S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [UM-BBD_reactionID:r1313] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0827 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034875 +name: caffeine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [UM-BBD_reactionID:r1321] +xref: EC:1.17.5.- +xref: UM-BBD_enzymeID:e0831 +is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor + +[Term] +id: GO:0034876 +name: isonicotinic acid hydrazide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [UM-BBD_reactionID:r1336] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0833 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034877 +name: isonicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [UM-BBD_reactionID:r1337] +xref: EC:1.15.99.- +xref: UM-BBD_enzymeID:e0835 +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0034878 +name: 2-hydroxyisonicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [UM-BBD_reactionID:r1338] +xref: EC:1.15.99.- +xref: UM-BBD_enzymeID:e0836 +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0034879 +name: 2,3,6-trihydroxyisonicotinate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [UM-BBD_reactionID:r1340] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0837 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034880 +name: citrazinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1339] +xref: EC:1.15.99.- +xref: UM-BBD_enzymeID:e0838 +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0034881 +name: citrazinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [UM-BBD_reactionID:r1343] +xref: EC:3.5.2.- +xref: UM-BBD_enzymeID:e0839 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0034882 +name: cis-aconitamide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [UM-BBD_reactionID:r1344] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0840 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034883 +name: isonicotinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0841 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034884 +name: gamma-N-formylaminovinylacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349] +xref: EC:1.2.99.- +xref: UM-BBD_enzymeID:e0842 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0034885 +name: gamma-N-formylaminovinylacetate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-N-formylaminovinylacetate + h@O = gamma-aminovinylacetate+ HCOOH." [UM-BBD_reactionID:r1350] +xref: EC:3.5.1.- +xref: UM-BBD_enzymeID:e0843 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034886 +name: gamma-aminovinylacetate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351] +xref: EC:3.5.99.- +xref: UM-BBD_enzymeID:e0844 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034887 +name: 1,4-dihydroisonicotinate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0845 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034888 +name: endosulfan monooxygenase I activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [UM-BBD_reactionID:r1382] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0856 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034889 +name: endosulfan hemisulfate sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + SO4." [UM-BBD_reactionID:r1384] +xref: EC:3.1.6.- +xref: UM-BBD_enzymeID:e0858 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0034890 +name: endosulfan diol hydrolyase (cyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [UM-BBD_reactionID:r1386] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0860 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034891 +name: endosulfan diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [UM-BBD_reactionID:r1388] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0861 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034892 +name: endosulfan lactone lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [UM-BBD_reactionID:r1389] +xref: EC:3.1.1.- +xref: UM-BBD_enzymeID:e0862 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0034893 +name: N-nitrodimethylamine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [UM-BBD_reactionID:r1395] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0864 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034894 +name: 4-hydroxypyridine-3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pryidine-3,4-diol + H2O + NAHP+." [UM-BBD_reactionID:r1397] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0865 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034895 +name: pyridine-3,4-diol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0866 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034896 +name: 3-formiminopyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400] +xref: EC:3.5.99.- +xref: UM-BBD_enzymeID:e0867 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034897 +name: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [UM-BBD_reactionID:r1358] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0869 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034898 +name: hexadecyltrimethylammonium chloride monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373] +xref: EC:1.13.12.- +xref: UM-BBD_enzymeID:e0872 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034899 +name: trimethylamine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + NADH + H+ + O2 = trimethylamine N-oxide + NAD+ + H2O." [UM-BBD_reactionID:r1407] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0873 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034900 +name: 3-(N-formyl)-formiminopyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399] +xref: EC:3.5.99.- +xref: UM-BBD_enzymeID:e0888 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034901 +name: endosulfan hydroxyether dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1411] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0894 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034902 +name: endosulfan sulfate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + SO3." [UM-BBD_reactionID:r1387] +xref: EC:3.1.6.- +xref: UM-BBD_enzymeID:e0895 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0034903 +name: endosulfan ether monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [UM-BBD_reactionID:r1413] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0897 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034904 +name: 5-chloro-2-oxopent-4-enoate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [UM-BBD_reactionID:r1436] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0906 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034905 +name: 5-chloro-4-hydroxy-2-oxopentanate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437] +xref: EC:4.1.3.- +xref: UM-BBD_enzymeID:e0907 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0034906 +name: N-isopropylaniline 1,2-dixoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0908 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034907 +name: acetanilide 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0909 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034908 +name: 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0910 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034909 +name: 6-hydroxypseudooxynicotine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 E- + NH2CH3." [UM-BBD_reactionID:r1441] +xref: EC:1.5.-.- +xref: UM-BBD_enzymeID:e0912 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034910 +name: 6-hydroxy-3-succinoylpyridine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [UM-BBD_reactionID:r1442] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0913 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034911 +name: phthalate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol+ NAD+." [UM-BBD_reactionID:r1444] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0914 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034912 +name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445] +xref: EC:1.3.1.- +xref: UM-BBD_enzymeID:e0915 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034913 +name: 3,4-dihydroxyphthalate 2-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2." [UM-BBD_reactionID:r1447] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0917 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034914 +name: TNP hydride denitratase activity +namespace: molecular_function +def: "Catalysis of the reaction: TNP hydride Meisenheimer complex = 2,4-dinitrophenol + NO2-." [UM-BBD_reactionID:r1448] +xref: EC:1.7.99.- +xref: UM-BBD_enzymeID:e0921 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0034915 +name: 2-methylhexanoyl-CoA C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0580 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0034916 +name: 2-methylhexanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928] +xref: EC:1.3.99.- +xref: UM-BBD_enzymeID:e0581 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034917 +name: 2-methylhex-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0929] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0582 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034918 +name: 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0930] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0583 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034919 +name: butyryl-CoA 2-C-propionyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [UM-BBD_reactionID:r0931] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0584 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0034920 +name: pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0585 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034921 +name: cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0935] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0586 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034922 +name: 4,5-dihydroxypyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0587 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034923 +name: phenanthrene-4,5-dicarboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [UM-BBD_reactionID:r0937] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0588 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034924 +name: cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [UM-BBD_reactionID:r0940] +xref: EC:1.3.-.- +xref: UM-BBD_enzymeID:e0589 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034925 +name: pyrene 4,5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryene + O2 + 2 H+ + 2 e- = pryene-4,5-oxide + H2O." [UM-BBD_reactionID:r0941] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0590 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034926 +name: pyrene-4,5-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0942] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0591 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0034927 +name: pyrene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryene + O2 + 2 H+ + 2 e- = pryene-1,2-oxide + H2O." [UM-BBD_reactionID:r0943] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0592 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034928 +name: 1-hydroxypyrene 6,7-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0946] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0594 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034929 +name: 1-hydroxypyrene 7,8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene +O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [UM-BBD_reactionID:r0949] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0596 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034930 +name: 1-hydroxypyrene sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pryenylsulfate + HX." [UM-BBD_reactionID:r0952] +xref: EC:2.8.2.- +xref: UM-BBD_enzymeID:e0598 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0034931 +name: 1-hydroxypyrene methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [UM-BBD_reactionID:r0953] +xref: EC:2.1.1.- +xref: UM-BBD_enzymeID:e0599 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034932 +name: 1-methoxypyrene 6,7-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0954] +xref: EC:1.4.-.- +xref: UM-BBD_enzymeID:e0600 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0034933 +name: 1-hydroxy-6-methoxypyrene methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [UM-BBD_reactionID:r0956] +xref: EC:2.1.1.- +xref: UM-BBD_enzymeID:e0602 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034934 +name: phenanthrene-4-carboxylate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0603 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034935 +name: tetrachlorobenzene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0604 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034936 +name: 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0605 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034937 +name: perchlorate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0608 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034938 +name: pyrrole-2-carboxylate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O." [UM-BBD_reactionID:r0968] +xref: EC:1.14.14.- +xref: UM-BBD_enzymeID:e0611 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034939 +name: 5-hydroxypyrrole-2-carboxylate tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [UM-BBD_reactionID:r0969] +xref: EC:5.3.2.- +xref: UM-BBD_enzymeID:e0612 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0034940 +name: 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [UM-BBD_reactionID:r0984] +xref: EC:3.5.2.- +xref: UM-BBD_enzymeID:e0613 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0034941 +name: pyrrole-2-carboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0614 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034942 +name: cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0988] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0616 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034943 +name: trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0989] +xref: EC:6.2.1.- +xref: UM-BBD_enzymeID:e0617 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034944 +name: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [UM-BBD_reactionID:r0986] +xref: EC:1.1.-.- +xref: UM-BBD_enzymeID:e0618 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034945 +name: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-Isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987] +xref: EC:2.3.1.- +xref: UM-BBD_enzymeID:e0619 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0034946 +name: 3-isopropylbut-3-enoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [UM-BBD_reactionID:r0994] +xref: EC:3.1.2.- +xref: UM-BBD_enzymeID:e0620 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0034947 +name: terephthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [UM-BBD_reactionID:r0321] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0621 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034948 +name: 2,6-dihydroxypseudooxynicotine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482] +xref: EC:3.7.1.- +xref: UM-BBD_enzymeID:e0625 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034949 +name: 1,1-dichloroethane reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0627 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034950 +name: phenylboronic acid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [UM-BBD_reactionID:r1020] +xref: EC:1.14.-.- +xref: UM-BBD_enzymeID:e0630 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034951 +name: o-hydroxylaminobenzoate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026] +xref: EC:5.4.99.- +xref: UM-BBD_enzymeID:e0632 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0034952 +name: malonate semialdehyde decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [UM-BBD_reactionID:r0266] +xref: EC:4.1.1.- +xref: UM-BBD_enzymeID:e0634 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034953 +name: perillyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r1002] +xref: EC:4.2.1.- +xref: UM-BBD_enzymeID:e0635 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034954 +name: diphenyl ether 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0922 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034955 +name: 2,3-dihydroxydiphenyl ether dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0923 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034956 +name: diphenyl ether 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0925 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034957 +name: 3-nitrophenol nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [UM-BBD_reactionID:r1495] +xref: EC:1.7.1.- +xref: UM-BBD_enzymeID:e0952 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0034958 +name: aminohydroquinone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497] +xref: EC:3.5.99.- +xref: UM-BBD_enzymeID:e0954 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034959 +name: endothelin maturation +namespace: biological_process +def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:rl] +is_a: GO:0016486 ! peptide hormone processing +is_a: GO:0051605 ! protein maturation via proteolysis +relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood + +[Term] +id: GO:0034960 +name: cellular biopolymer metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells." [GOC:mah] +synonym: "cellular biopolymer metabolism" EXACT [] +is_a: GO:0043283 ! biopolymer metabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0034961 +name: cellular biopolymer biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells." [GOC:mah] +synonym: "cellular biopolymer anabolism" EXACT [] +synonym: "cellular biopolymer biosynthesis" RELATED [] +synonym: "cellular biopolymer formation" EXACT [] +synonym: "cellular biopolymer synthesis" EXACT [] +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0034960 ! cellular biopolymer metabolic process +is_a: GO:0043284 ! biopolymer biosynthetic process + +[Term] +id: GO:0034962 +name: cellular biopolymer catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells." [GOC:mah] +synonym: "cellular biopolymer breakdown" RELATED [] +synonym: "cellular biopolymer catabolism" EXACT [] +synonym: "cellular biopolymer degradation" EXACT [] +is_a: GO:0034960 ! cellular biopolymer metabolic process +is_a: GO:0043285 ! biopolymer catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0034963 +name: box C/D snoRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA." [GOC:mah] +is_a: GO:0033967 ! box C/D snoRNA metabolic process +is_a: GO:0043144 ! snoRNA processing + +[Term] +id: GO:0034964 +name: box H/ACA snoRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA." [GOC:mah] +is_a: GO:0033979 ! box H/ACA snoRNA metabolic process +is_a: GO:0043144 ! snoRNA processing + +[Term] +id: GO:0034965 +name: intronic box C/D snoRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:mah] +is_a: GO:0031070 ! intronic snoRNA processing +is_a: GO:0034963 ! box C/D snoRNA processing + +[Term] +id: GO:0034966 +name: intronic box H/ACA snoRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah] +is_a: GO:0031070 ! intronic snoRNA processing +is_a: GO:0034964 ! box H/ACA snoRNA processing + +[Term] +id: GO:0034967 +name: Set3 complex +namespace: cellular_component +def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434] +synonym: "HDAC3 complex" EXACT [] +synonym: "SET3C" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0034968 +name: histone lysine methylation +namespace: biological_process +def: "The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah] +is_a: GO:0016571 ! histone methylation + +[Term] +id: GO:0034969 +name: histone arginine methylation +namespace: biological_process +def: "The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah] +is_a: GO:0016571 ! histone methylation + +[Term] +id: GO:0034970 +name: histone H3-R2 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah] +synonym: "histone H3 R2 methylation" EXACT [] +synonym: "histone H3R2me" EXACT [] +synonym: "histone lysine H3 R2 methylation" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0034971 +name: histone H3-R17 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah] +synonym: "histone H3 R17 methylation" EXACT [] +synonym: "histone H3R17me" EXACT [] +synonym: "histone lysine H3 R17 methylation" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0034972 +name: histone H3-R26 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah] +synonym: "histone H3 R26 methylation" EXACT [] +synonym: "histone H3R26me" EXACT [] +synonym: "histone lysine H3 R26 methylation" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0034973 +name: Sid2-Mob1 complex +namespace: cellular_component +def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149] +synonym: "Dbf2p-Mob1p complex" EXACT [] +synonym: "Sid2-Mob1 kinase complex" EXACT [] +synonym: "Sid2p-Mob1p complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034974 +name: Swi5-Swi2 complex +namespace: cellular_component +def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140] +comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p. +synonym: "Swi5 complex" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000790 ! nuclear chromatin + +[Term] +id: GO:0034975 +name: protein folding in endoplasmic reticulum +namespace: biological_process +def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] +synonym: "protein folding in ER" EXACT [] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0034976 +name: response to endoplasmic reticulum stress +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah] +synonym: "ER stress response" EXACT [] +synonym: "response to ER stress" EXACT [] +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0034977 +name: ABIN2-NFKB1-MAP3K8 complex +namespace: cellular_component +def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888] +synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0034978 +name: PDX1-PBX1b-MRG1 complex +namespace: cellular_component +def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595] +synonym: "acinar cell-specific C complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0034979 +name: NAD-dependent protein deacetylase activity +namespace: molecular_function +def: "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:mah] +is_a: GO:0033558 ! protein deacetylase activity + +[Term] +id: GO:0034980 +name: FHL2-CREB complex +namespace: cellular_component +def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156] +is_a: GO:0033202 ! DNA helicase complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0034981 +name: FHL3-CREB complex +namespace: cellular_component +def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156] +is_a: GO:0033202 ! DNA helicase complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0034982 +name: mitochondrial protein processing +namespace: biological_process +def: "The posttranslational modification of proteins in the mitochondrion, including proteolytic cleavage of proteins that occurs during import into the mitochondrion." [GOC:mah] +synonym: "mitochondrial protein modification" RELATED [] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0034983 +name: peptidyl-lysine deacetylation +namespace: biological_process +def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:mah] +synonym: "protein lysine acetylation" RELATED [] +is_a: GO:0006476 ! protein amino acid deacetylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0034984 +name: cellular response to DNA damage stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:mah] +synonym: "cellular DNA damage response" EXACT [] +is_a: GO:0006974 ! response to DNA damage stimulus +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0034985 +name: Ecsit-NDUFAF1 complex +namespace: cellular_component +def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420] +is_a: GO:0043234 ! protein complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0034986 +name: iron chaperone activity +namespace: molecular_function +def: "Assists in the delivery of iron ions to target proteins or compartments." [GOC:vk] +is_a: GO:0005506 ! iron ion binding +is_a: GO:0016530 ! metallochaperone activity + +[Term] +id: GO:0034987 +name: immunoglobulin receptor binding +namespace: molecular_function +def: "Interacting selectively with one or more specific sites on an immunoglobulin receptor molecule." [GOC:vk] +synonym: "Fc receptor binding" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0034988 +name: Fc-gamma receptor I complex binding +namespace: molecular_function +def: "Interacting selectively with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:vk] +is_a: GO:0034987 ! immunoglobulin receptor binding + +[Term] +id: GO:0034989 +name: GTP-Ral binding +namespace: molecular_function +def: "Interacting selectively with the GTP-bound form of the Ral protein." [GOC:vk] +is_a: GO:0017160 ! Ral GTPase binding + +[Term] +id: GO:0034990 +name: nuclear mitotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah] +comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. +is_a: GO:0000798 ! nuclear cohesin complex +is_a: GO:0030892 ! mitotic cohesin complex + +[Term] +id: GO:0034991 +name: nuclear meiotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah] +comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. +is_a: GO:0000798 ! nuclear cohesin complex +is_a: GO:0030893 ! meiotic cohesin complex + +[Term] +id: GO:0034992 +name: microtubule organizing center attachment site +namespace: cellular_component +def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466] +comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. +synonym: "MAS" EXACT [] +synonym: "microtubule organising centre attachment site" EXACT [] +synonym: "MTOC attachment site" EXACT [] +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0034993 +name: SUN-KASH complex +namespace: cellular_component +def: "A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains." [GOC:mah, PMID:18692466] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0034992 ! microtubule organizing center attachment site + +[Term] +id: GO:0034994 +name: microtubule organizing center attachment site organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466] +synonym: "MAS organization" EXACT [] +synonym: "microtubule organising centre attachment site organisation" RELATED [] +synonym: "MTOC attachment site organization" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0034995 +name: SC5b-7 complex +namespace: cellular_component +def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0034996 +name: RasGAP-Fyn-Lyn-Yes complex +namespace: cellular_component +def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0034997 +name: alphav-beta5 integrin-vitronectin complex +namespace: cellular_component +def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173, Reactome:REACT_14045.1] +synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0034998 +name: oligosaccharyltransferase I complex +namespace: cellular_component +def: "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887] +synonym: "OSTCI" EXACT [] +is_a: GO:0008250 ! oligosaccharyltransferase complex + +[Term] +id: GO:0034999 +name: oligosaccharyltransferase II complex +namespace: cellular_component +def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [PMID:15835887] +synonym: "OSTCII" EXACT [] +is_a: GO:0008250 ! oligosaccharyltransferase complex + +[Term] +id: GO:0035000 +name: oligosaccharyltransferase III complex +namespace: cellular_component +def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887] +synonym: "OSTCIII" EXACT [] +is_a: GO:0008250 ! oligosaccharyltransferase complex + +[Term] +id: GO:0035001 +name: dorsal trunk growth, open tracheal system +namespace: biological_process +def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "dorsal trunk growth" RELATED [] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035002 +name: liquid clearance, open tracheal system +namespace: biological_process +def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] +synonym: "tracheal liquid clearance" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035003 +name: subapical complex +namespace: cellular_component +def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] +synonym: "SAC" BROAD [] +is_a: GO:0005911 ! cell-cell junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0035004 +name: phosphoinositide 3-kinase activity +namespace: molecular_function +def: "Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]." [GOC:bf, PMID:10209156, PMID:9255069] +xref: EC:2.7.1.- +is_a: GO:0001727 ! lipid kinase activity +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0035005 +name: phosphatidylinositol-4-phosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate." [EC:2.7.1.154, GOC:bf] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.154] +synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154] +synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] +synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154] +xref: EC:2.7.1.154 +xref: MetaCyc:2.7.1.154-RXN +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity +is_a: GO:0035004 ! phosphoinositide 3-kinase activity + +[Term] +id: GO:0035006 +name: melanization defense response +namespace: biological_process +def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] +synonym: "melanization defence response" EXACT [] +is_a: GO:0006582 ! melanin metabolic process +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0035007 +name: regulation of melanization defense response +namespace: biological_process +def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] +synonym: "regulation of melanization defence response" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0035006 ! melanization defense response + +[Term] +id: GO:0035008 +name: positive regulation of melanization defense response +namespace: biological_process +def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] +synonym: "activation of melanization defense response" NARROW [] +synonym: "positive regulation of melanization defence response" EXACT [] +synonym: "stimulation of melanization defense response" NARROW [] +synonym: "up regulation of melanization defense response" EXACT [] +synonym: "up-regulation of melanization defense response" EXACT [] +synonym: "upregulation of melanization defense response" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0035007 ! regulation of melanization defense response +is_a: GO:0045089 ! positive regulation of innate immune response +relationship: positively_regulates GO:0035006 ! melanization defense response + +[Term] +id: GO:0035009 +name: negative regulation of melanization defense response +namespace: biological_process +def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809] +synonym: "down regulation of melanization defense response" EXACT [] +synonym: "down-regulation of melanization defense response" EXACT [] +synonym: "downregulation of melanization defense response" EXACT [] +synonym: "inhibition of melanization defense response" NARROW [] +synonym: "negative regulation of melanization defence response" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0035007 ! regulation of melanization defense response +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0035006 ! melanization defense response + +[Term] +id: GO:0035010 +name: encapsulation of foreign target +namespace: biological_process +def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920] +comment: This term was improved by GO_REF:0000022. It was moved. +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0035011 +name: melanotic encapsulation of foreign target +namespace: biological_process +def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] +is_a: GO:0035006 ! melanization defense response +is_a: GO:0035010 ! encapsulation of foreign target + +[Term] +id: GO:0035012 +name: polytene chromosome, telomeric region +namespace: cellular_component +def: "The terminal region of a polytene chromosome." [GOC:bf] +is_a: GO:0000781 ! chromosome, telomeric region +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0035013 +name: myosuppressin receptor activity +namespace: molecular_function +def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0035014 +name: phosphoinositide 3-kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] +comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'. +synonym: "PI3K regulator activity" EXACT [] +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0035015 +name: elongation of arista core +namespace: biological_process +def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048800 ! antennal morphogenesis + +[Term] +id: GO:0035016 +name: elongation of arista lateral +namespace: biological_process +def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048800 ! antennal morphogenesis + +[Term] +id: GO:0035017 +name: cuticle pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0035018 +name: adult chitin-based cuticle pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle." [GOC:bf, GOC:mtg_sensu] +synonym: "adult cuticle pattern formation (sensu Insecta)" EXACT [] +is_a: GO:0035017 ! cuticle pattern formation +relationship: part_of GO:0008365 ! adult chitin-based cuticle development + +[Term] +id: GO:0035019 +name: somatic stem cell maintenance +namespace: biological_process +def: "The process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] +is_a: GO:0019827 ! stem cell maintenance + +[Term] +id: GO:0035020 +name: regulation of Rac protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0016601 ! Rac protein signal transduction + +[Term] +id: GO:0035021 +name: negative regulation of Rac protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] +synonym: "down regulation of Rac protein signal transduction" EXACT [] +synonym: "down-regulation of Rac protein signal transduction" EXACT [] +synonym: "downregulation of Rac protein signal transduction" EXACT [] +synonym: "inhibition of Rac protein signal transduction" NARROW [] +is_a: GO:0035020 ! regulation of Rac protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction + +[Term] +id: GO:0035022 +name: positive regulation of Rac protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] +synonym: "activation of Rac protein signal transduction" NARROW [] +synonym: "stimulation of Rac protein signal transduction" NARROW [] +synonym: "up regulation of Rac protein signal transduction" EXACT [] +synonym: "up-regulation of Rac protein signal transduction" EXACT [] +synonym: "upregulation of Rac protein signal transduction" EXACT [] +is_a: GO:0035020 ! regulation of Rac protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0016601 ! Rac protein signal transduction + +[Term] +id: GO:0035023 +name: regulation of Rho protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0035024 +name: negative regulation of Rho protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] +synonym: "down regulation of Rho protein signal transduction" EXACT [] +synonym: "down-regulation of Rho protein signal transduction" EXACT [] +synonym: "downregulation of Rho protein signal transduction" EXACT [] +synonym: "inhibition of Rho protein signal transduction" NARROW [] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0035025 +name: positive regulation of Rho protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] +synonym: "activation of Rho protein signal transduction" NARROW [] +synonym: "stimulation of Rho protein signal transduction" NARROW [] +synonym: "up regulation of Rho protein signal transduction" EXACT [] +synonym: "up-regulation of Rho protein signal transduction" EXACT [] +synonym: "upregulation of Rho protein signal transduction" EXACT [] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0035026 +name: leading edge cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0035027 +name: leading edge cell fate commitment +namespace: biological_process +def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0035026 ! leading edge cell differentiation + +[Term] +id: GO:0035028 +name: leading edge cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0035027 ! leading edge cell fate commitment + +[Term] +id: GO:0035029 +name: dorsal closure, leading edge cell fate commitment +namespace: biological_process +def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf] +is_a: GO:0035027 ! leading edge cell fate commitment +relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation + +[Term] +id: GO:0035032 +name: phosphoinositide 3-kinase complex, class III +namespace: cellular_component +def: "A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069] +synonym: "class III PI3K complex" EXACT [] +is_a: GO:0005942 ! phosphoinositide 3-kinase complex + +[Term] +id: GO:0035033 +name: histone deacetylase regulator activity +namespace: molecular_function +def: "Modulates the activity of histone deacetylase." [GOC:bf] +comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'. +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0035034 +name: histone acetyltransferase regulator activity +namespace: molecular_function +def: "Modulates the activity of histone acetyltransferase." [GOC:bf] +comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. +synonym: "histone acetylase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0035035 +name: histone acetyltransferase binding +namespace: molecular_function +def: "Interacting selectively with the enzyme histone acetyltransferase." [GOC:bf] +synonym: "histone acetylase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0035036 +name: sperm-egg recognition +namespace: biological_process +def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] +is_a: GO:0009988 ! cell-cell recognition +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035037 +name: sperm entry +namespace: biological_process +def: "Penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751] +is_a: GO:0006897 ! endocytosis +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035038 +name: female pronucleus formation +namespace: biological_process +def: "Formation of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089] +is_a: GO:0006997 ! nucleus organization +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035039 +name: male pronucleus formation +namespace: biological_process +def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001] +is_a: GO:0006997 ! nucleus organization +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035040 +name: sperm nuclear envelope removal +namespace: biological_process +def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001] +is_a: GO:0051081 ! nuclear envelope disassembly +relationship: part_of GO:0035039 ! male pronucleus formation + +[Term] +id: GO:0035041 +name: sperm chromatin decondensation +namespace: biological_process +def: "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001] +is_a: GO:0006325 ! establishment or maintenance of chromatin architecture +relationship: part_of GO:0035039 ! male pronucleus formation + +[Term] +id: GO:0035042 +name: fertilization, exchange of chromosomal proteins +namespace: biological_process +def: "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001] +synonym: "sperm-specific histone exchange" EXACT [] +synonym: "sperm-specific histone replacement" EXACT [] +is_a: GO:0043486 ! histone exchange +relationship: part_of GO:0035041 ! sperm chromatin decondensation + +[Term] +id: GO:0035043 +name: male pronuclear envelope synthesis +namespace: biological_process +def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001] +is_a: GO:0018985 ! pronuclear envelope synthesis +relationship: part_of GO:0035039 ! male pronucleus formation + +[Term] +id: GO:0035044 +name: sperm aster formation +namespace: biological_process +def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] +is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035045 +name: sperm plasma membrane disassembly +namespace: biological_process +def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238] +synonym: "sperm plasma membrane breakdown" EXACT [] +synonym: "sperm plasma membrane catabolism" EXACT [] +synonym: "sperm plasma membrane degradation" EXACT [] +is_a: GO:0030397 ! membrane disassembly +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035046 +name: pronuclear migration +namespace: biological_process +def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035047 +name: centrosomal and pronuclear rotation +namespace: biological_process +def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035048 +name: splicing factor protein import into nucleus +namespace: biological_process +def: "The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf] +synonym: "splicing factor protein import into nucleus" EXACT [] +synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT [] +synonym: "splicing factor protein-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0035049 +name: juvenile hormone acid methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0035050 +name: embryonic heart tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0007507 ! heart development +is_a: GO:0035295 ! tube development +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0035051 +name: cardiac cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] +synonym: "heart cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0035052 +name: dorsal vessel aortic cell fate commitment +namespace: biological_process +def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells." [GOC:bf, GOC:mtg_sensu, PMID:12397110] +synonym: "aortic cell fate commitment (sensu Insecta)" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0035051 ! cardiac cell differentiation +relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern formation + +[Term] +id: GO:0035053 +name: dorsal vessel heart proper cell fate commitment +namespace: biological_process +def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells." [GOC:bf, GOC:mtg_sensu, PMID:12397110] +synonym: "heart proper cell fate commitment (sensu Insecta)" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0035051 ! cardiac cell differentiation +relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern formation + +[Term] +id: GO:0035054 +name: embryonic heart tube anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360] +is_a: GO:0009952 ! anterior/posterior pattern formation +relationship: part_of GO:0035050 ! embryonic heart tube development + +[Term] +id: GO:0035058 +name: sensory cilium biogenesis +namespace: biological_process +def: "The assembly of a sensory cilium, a primary cilium found on sensory neurons that contains an a 9+0 axonemal arrangement of microtubules." [GOC:bf, PMID:14521833, PMID:14521834] +is_a: GO:0042384 ! cilium biogenesis + +[Term] +id: GO:0035059 +name: RCAF complex +namespace: cellular_component +def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219] +synonym: "replication-coupling assembly factor complex" EXACT [] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0035060 +name: brahma complex +namespace: cellular_component +def: "A multi-subunit ATP-dependent chromatin remodeling complex, a counterpart of the SWI/SNF complex that contains the ATPase product of the Drosophila brahma gene." [GOC:bf, PMID:10809665, PMID:12482982] +synonym: "BRM complex" EXACT [] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0035061 +name: interchromatin granule +namespace: cellular_component +def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] +synonym: "ICG" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0035062 +name: omega speckle +namespace: cellular_component +def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] +is_a: GO:0016607 ! nuclear speck + +[Term] +id: GO:0035063 +name: nuclear speck organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators] +comment: See also the cellular component term 'nuclear speck ; GO:0016607'. +synonym: "nuclear speck organisation and biogenesis" EXACT [] +synonym: "nuclear speck organization and biogenesis" EXACT [] +synonym: "nuclear speckle assembly" EXACT [] +synonym: "nuclear speckle organization and biogenesis" EXACT [] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0035064 +name: methylated histone residue binding +namespace: molecular_function +def: "Interacting selectively with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615] +is_a: GO:0042393 ! histone binding + +[Term] +id: GO:0035065 +name: regulation of histone acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] +is_a: GO:0031056 ! regulation of histone modification +relationship: regulates GO:0016573 ! histone acetylation + +[Term] +id: GO:0035066 +name: positive regulation of histone acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] +synonym: "activation of histone acetylation" NARROW [] +synonym: "stimulation of histone acetylation" NARROW [] +synonym: "up regulation of histone acetylation" EXACT [] +synonym: "up-regulation of histone acetylation" EXACT [] +synonym: "upregulation of histone acetylation" EXACT [] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0035065 ! regulation of histone acetylation +relationship: positively_regulates GO:0016573 ! histone acetylation + +[Term] +id: GO:0035067 +name: negative regulation of histone acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] +synonym: "down regulation of histone acetylation" EXACT [] +synonym: "down-regulation of histone acetylation" EXACT [] +synonym: "downregulation of histone acetylation" EXACT [] +synonym: "inhibition of histone acetylation" NARROW [] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0035065 ! regulation of histone acetylation +relationship: negatively_regulates GO:0016573 ! histone acetylation + +[Term] +id: GO:0035068 +name: micro-ribonucleoprotein complex +namespace: cellular_component +def: "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182] +synonym: "miRNP complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex + +[Term] +id: GO:0035069 +name: larval midgut histolysis +namespace: biological_process +def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] +is_a: GO:0007559 ! histolysis +relationship: part_of GO:0007552 ! metamorphosis +relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis + +[Term] +id: GO:0035070 +name: salivary gland histolysis +namespace: biological_process +def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683] +is_a: GO:0007559 ! histolysis +relationship: part_of GO:0007431 ! salivary gland development +relationship: part_of GO:0007552 ! metamorphosis +relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis + +[Term] +id: GO:0035071 +name: salivary gland cell autophagic cell death +namespace: biological_process +def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, PMID:10882130] +synonym: "autophagic cell death of salivary gland cells" EXACT [] +synonym: "programmed cell death of salivary gland cells by autophagy" EXACT [] +synonym: "salivary gland cell death" EXACT [] +synonym: "salivary gland cell programmed cell death by autophagy" EXACT [] +is_a: GO:0048102 ! autophagic cell death +relationship: part_of GO:0035070 ! salivary gland histolysis + +[Term] +id: GO:0035072 +name: ecdysone-mediated induction of salivary gland cell autophagic cell death +namespace: biological_process +def: "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] +synonym: "ecdysone-mediated induction of autophagic cell death of salivary gland cells" EXACT [] +synonym: "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy" EXACT [] +synonym: "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy" EXACT [] +is_a: GO:0035078 ! induction of programmed cell death by ecdysone +relationship: part_of GO:0035071 ! salivary gland cell autophagic cell death + +[Term] +id: GO:0035073 +name: pupariation +namespace: biological_process +def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] +synonym: "puparium biosynthesis" EXACT [] +synonym: "puparium formation" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0035210 ! prepupal development + +[Term] +id: GO:0035074 +name: pupation +namespace: biological_process +def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] +synonym: "head eversion" EXACT [] +synonym: "prepupal-pupal transition" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0035209 ! pupal development + +[Term] +id: GO:0035075 +name: response to ecdysone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] +is_a: GO:0048545 ! response to steroid hormone stimulus +relationship: part_of GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0035076 +name: ecdysone receptor-mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] +synonym: "ecdysone receptor-mediated signalling pathway" EXACT [] +is_a: GO:0030518 ! steroid hormone receptor signaling pathway +is_a: GO:0035075 ! response to ecdysone + +[Term] +id: GO:0035077 +name: ecdysone-mediated polytene chromosome puffing +namespace: biological_process +def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962] +is_a: GO:0035075 ! response to ecdysone +is_a: GO:0035079 ! polytene chromosome puffing + +[Term] +id: GO:0035078 +name: induction of programmed cell death by ecdysone +namespace: biological_process +def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf] +is_a: GO:0035075 ! response to ecdysone +is_a: GO:0035081 ! induction of programmed cell death by hormones + +[Term] +id: GO:0035079 +name: polytene chromosome puffing +namespace: biological_process +def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0035080 +name: heat shock-mediated polytene chromosome puffing +namespace: biological_process +def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] +is_a: GO:0034605 ! cellular response to heat +is_a: GO:0035079 ! polytene chromosome puffing + +[Term] +id: GO:0035081 +name: induction of programmed cell death by hormones +namespace: biological_process +def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf] +is_a: GO:0012502 ! induction of programmed cell death + +[Term] +id: GO:0035082 +name: axoneme biogenesis +namespace: biological_process +def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194] +is_a: GO:0001578 ! microtubule bundle formation +relationship: part_of GO:0030031 ! cell projection biogenesis + +[Term] +id: GO:0035083 +name: cilium axoneme biogenesis +namespace: biological_process +def: "The assembly and organization of a the bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194] +is_a: GO:0035082 ! axoneme biogenesis +relationship: part_of GO:0042384 ! cilium biogenesis + +[Term] +id: GO:0035084 +name: flagellar axoneme biogenesis +namespace: biological_process +def: "The assembly and organization of a the bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194] +synonym: "flagella axoneme biogenesis" EXACT [] +synonym: "flagellum axoneme biogenesis" RELATED [] +is_a: GO:0035082 ! axoneme biogenesis +relationship: part_of GO:0009296 ! flagellum biogenesis + +[Term] +id: GO:0035085 +name: cilium axoneme +namespace: cellular_component +def: "The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684] +is_a: GO:0005930 ! axoneme +is_a: GO:0044441 ! cilium part + +[Term] +id: GO:0035086 +name: flagellar axoneme +namespace: cellular_component +def: "The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684] +synonym: "flagellum axoneme" EXACT [] +is_a: GO:0005930 ! axoneme +is_a: GO:0044442 ! microtubule-based flagellum part + +[Term] +id: GO:0035087 +name: RNA interference, siRNA loading onto RISC +namespace: biological_process +def: "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC)." [GOC:bf, PMID:14512631] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0035088 +name: establishment or maintenance of apical/basal cell polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0035089 +name: establishment of apical/basal cell polarity +namespace: biological_process +def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity + +[Term] +id: GO:0035090 +name: maintenance of apical/basal cell polarity +namespace: biological_process +def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf] +is_a: GO:0030011 ! maintenance of cell polarity +is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity + +[Term] +id: GO:0035091 +name: phosphoinositide binding +namespace: molecular_function +def: "Interacting selectively with any inositol-containing glycerophospholipid." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0035092 +name: sperm chromatin condensation +namespace: biological_process +def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001] +is_a: GO:0006323 ! DNA packaging +is_a: GO:0006325 ! establishment or maintenance of chromatin architecture +relationship: part_of GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0035093 +name: spermatogenesis, exchange of chromosomal proteins +namespace: biological_process +def: "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin." [GOC:bf, PMID:11735001] +synonym: "somatic histone exchange" EXACT [] +synonym: "somatic histone replacement" RELATED [] +is_a: GO:0043486 ! histone exchange +relationship: part_of GO:0035092 ! sperm chromatin condensation + +[Term] +id: GO:0035094 +name: response to nicotine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [CHEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089] +is_a: GO:0014070 ! response to organic cyclic substance +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0035095 +name: behavioral response to nicotine +namespace: biological_process +def: "A change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "behavioural response to nicotine" EXACT [] +is_a: GO:0030534 ! adult behavior +is_a: GO:0035094 ! response to nicotine + +[Term] +id: GO:0035096 +name: larval midgut cell programmed cell death +namespace: biological_process +def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf] +synonym: "larval midgut cell death" EXACT [] +synonym: "programmed cell death of larval midgut cells" EXACT [] +is_a: GO:0010623 ! developmental programmed cell death +relationship: part_of GO:0035069 ! larval midgut histolysis + +[Term] +id: GO:0035097 +name: histone methyltransferase complex +namespace: cellular_component +def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf] +subset: goslim_pir +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0035098 +name: ESC/E(Z) complex +namespace: cellular_component +def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12." [GOC:bf, PMID:12408863, PMID:12408864] +synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT [] +is_a: GO:0031519 ! PcG protein complex +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0035099 +name: hemocyte migration +namespace: biological_process +def: "The directed movement of hemocytes within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] +synonym: "arthropod blood cell migration" EXACT [] +synonym: "hemocyte cell migration (sensu Arthropoda)" EXACT [] +synonym: "hemocyte migration (sensu Arthropoda)" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0035162 ! embryonic hemopoiesis + +[Term] +id: GO:0035100 +name: ecdysone binding +namespace: molecular_function +def: "Interacting selectively with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089] +is_a: GO:0005496 ! steroid binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0035101 +name: FACT complex +namespace: cellular_component +def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108] +synonym: "Facilitates chromatin transcription complex" EXACT [] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0035102 +name: PRC1 complex +namespace: cellular_component +def: "An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays." [GOC:bf, PMID:10412979] +synonym: "Polycomb repressive complex 1" EXACT [] +is_a: GO:0031519 ! PcG protein complex + +[Term] +id: GO:0035103 +name: sterol regulatory element binding protein cleavage +namespace: biological_process +def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, PMID:12923525] +synonym: "SREBP cleavage" EXACT [] +is_a: GO:0016485 ! protein processing +relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway + +[Term] +id: GO:0035104 +name: positive regulation of transcription via sterol regulatory element binding +namespace: biological_process +def: "The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs in the promoters of target genes." [GOC:bf, GOC:mah, PMID:12923525] +synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW [] +synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb] +synonym: "SREBP target gene transcriptional activation" EXACT [] +synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD [] +synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW [] +synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT [] +synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT [] +synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT [] +is_a: GO:0010552 ! positive regulation of specific transcription from RNA polymerase II promoter +relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway + +[Term] +id: GO:0035105 +name: sterol regulatory element binding protein nuclear translocation +namespace: biological_process +def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] +synonym: "SREBP nuclear translocation" EXACT [] +is_a: GO:0000060 ! protein import into nucleus, translocation +relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway + +[Term] +id: GO:0035106 +name: operant conditioning +namespace: biological_process +def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373] +synonym: "instrumental conditioning" EXACT [] +is_a: GO:0007612 ! learning + +[Term] +id: GO:0035107 +name: appendage morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [ISBN:0582227089] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048736 ! appendage development + +[Term] +id: GO:0035108 +name: limb morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin." [ISBN:0395825172] +synonym: "limb bud morphogenesis" NARROW [GOC:dph] +is_a: GO:0035107 ! appendage morphogenesis +relationship: part_of GO:0060173 ! limb development + +[Term] +id: GO:0035109 +name: imaginal disc-derived limb morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:mtg_sensu] +synonym: "limb morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0035108 ! limb morphogenesis +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis + +[Term] +id: GO:0035110 +name: leg morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001] +is_a: GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0035111 +name: leg joint morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of leg joint are generated and organized. Morphogenesis pertains to the creation of form. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. For example the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0035286 ! leg segmentation + +[Term] +id: GO:0035112 +name: genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of genitalia are generated and organized. Morphogenesis pertains to the creation of form. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] +synonym: "genital morphogenesis" RELATED [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0048806 ! genitalia development + +[Term] +id: GO:0035113 +name: embryonic appendage morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [ISBN:0582227089] +is_a: GO:0035107 ! appendage morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0035114 +name: imaginal disc-derived appendage morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089] +synonym: "appendage morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0035107 ! appendage morphogenesis +is_a: GO:0048737 ! imaginal disc-derived appendage development + +[Term] +id: GO:0035115 +name: embryonic forelimb morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an animal." [ISBN:0198612001] +is_a: GO:0030326 ! embryonic limb morphogenesis +is_a: GO:0035136 ! forelimb morphogenesis + +[Term] +id: GO:0035116 +name: embryonic hindlimb morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. Morphogenesis pertains to the creation of form. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001] +is_a: GO:0030326 ! embryonic limb morphogenesis +is_a: GO:0035137 ! hindlimb morphogenesis + +[Term] +id: GO:0035117 +name: embryonic arm morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the arm are generated and organized. Morphogenesis pertains to the creation of form. In humans, the arms are the two upper limbs of the body from the shoulder to the hand." [ISBN:0198612001] +is_a: GO:0035115 ! embryonic forelimb morphogenesis +is_a: GO:0035140 ! arm morphogenesis + +[Term] +id: GO:0035118 +name: embryonic pectoral fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035115 ! embryonic forelimb morphogenesis +is_a: GO:0035138 ! pectoral fin morphogenesis + +[Term] +id: GO:0035119 +name: embryonic pelvic fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035116 ! embryonic hindlimb morphogenesis +is_a: GO:0035139 ! pelvic fin morphogenesis + +[Term] +id: GO:0035120 +name: post-embryonic appendage morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [ISBN:0582227089] +is_a: GO:0009886 ! post-embryonic morphogenesis +is_a: GO:0035107 ! appendage morphogenesis + +[Term] +id: GO:0035121 +name: tail morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the tail are generated and organized. Morphogenesis pertains to the creation of form. The tail is the hindmost part of some animals." [ISBN:0198612001] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0035122 +name: embryonic medial fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] +synonym: "embryonic unpaired fin morphogenesis" EXACT [] +is_a: GO:0035141 ! medial fin morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0035123 +name: embryonic dorsal fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] +is_a: GO:0035122 ! embryonic medial fin morphogenesis +is_a: GO:0035142 ! dorsal fin morphogenesis + +[Term] +id: GO:0035124 +name: embryonic caudal fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] +is_a: GO:0035122 ! embryonic medial fin morphogenesis +is_a: GO:0035143 ! caudal fin morphogenesis + +[Term] +id: GO:0035125 +name: embryonic anal fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] +is_a: GO:0035122 ! embryonic medial fin morphogenesis +is_a: GO:0035144 ! anal fin morphogenesis + +[Term] +id: GO:0035126 +name: post-embryonic genitalia morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf] +synonym: "post-embryonic genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +is_a: GO:0048563 ! post-embryonic organ morphogenesis + +[Term] +id: GO:0035127 +name: post-embryonic limb morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172] +is_a: GO:0035108 ! limb morphogenesis +is_a: GO:0035120 ! post-embryonic appendage morphogenesis + +[Term] +id: GO:0035128 +name: post-embryonic forelimb morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an organism." [GOC:bf] +is_a: GO:0035127 ! post-embryonic limb morphogenesis +is_a: GO:0035136 ! forelimb morphogenesis + +[Term] +id: GO:0035129 +name: post-embryonic hindlimb morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf] +is_a: GO:0035127 ! post-embryonic limb morphogenesis +is_a: GO:0035137 ! hindlimb morphogenesis + +[Term] +id: GO:0035130 +name: post-embryonic pectoral fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035128 ! post-embryonic forelimb morphogenesis +is_a: GO:0035138 ! pectoral fin morphogenesis + +[Term] +id: GO:0035131 +name: post-embryonic pelvic fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035129 ! post-embryonic hindlimb morphogenesis +is_a: GO:0035139 ! pelvic fin morphogenesis + +[Term] +id: GO:0035132 +name: post-embryonic medial fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] +synonym: "post-embryonic unpaired fin morphogenesis" EXACT [] +is_a: GO:0009886 ! post-embryonic morphogenesis +is_a: GO:0035141 ! medial fin morphogenesis + +[Term] +id: GO:0035133 +name: post-embryonic caudal fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] +is_a: GO:0035132 ! post-embryonic medial fin morphogenesis +is_a: GO:0035143 ! caudal fin morphogenesis + +[Term] +id: GO:0035134 +name: post-embryonic dorsal fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] +is_a: GO:0035132 ! post-embryonic medial fin morphogenesis +is_a: GO:0035142 ! dorsal fin morphogenesis + +[Term] +id: GO:0035135 +name: post-embryonic anal fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] +is_a: GO:0035132 ! post-embryonic medial fin morphogenesis +is_a: GO:0035144 ! anal fin morphogenesis + +[Term] +id: GO:0035136 +name: forelimb morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0035137 +name: hindlimb morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0035138 +name: pectoral fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0033334 ! fin morphogenesis +is_a: GO:0035136 ! forelimb morphogenesis +relationship: part_of GO:0033339 ! pectoral fin development + +[Term] +id: GO:0035139 +name: pelvic fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0033334 ! fin morphogenesis +is_a: GO:0035137 ! hindlimb morphogenesis +relationship: part_of GO:0033340 ! pelvic fin development + +[Term] +id: GO:0035140 +name: arm morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the arm are generated and organized. Morphogenesis pertains to the creation of form. In humans, the arms are the two upper limbs of the body from the shoulder to the hand." [ISBN:0198612001] +is_a: GO:0035136 ! forelimb morphogenesis + +[Term] +id: GO:0035141 +name: medial fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] +synonym: "unpaired fin morphogenesis" EXACT [] +is_a: GO:0033334 ! fin morphogenesis +relationship: part_of GO:0033338 ! medial fin development + +[Term] +id: GO:0035142 +name: dorsal fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] +is_a: GO:0035141 ! medial fin morphogenesis +relationship: part_of GO:0033337 ! dorsal fin development + +[Term] +id: GO:0035143 +name: caudal fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh] +is_a: GO:0035141 ! medial fin morphogenesis +relationship: part_of GO:0033336 ! caudal fin development + +[Term] +id: GO:0035144 +name: anal fin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] +is_a: GO:0035141 ! medial fin morphogenesis +relationship: part_of GO:0033335 ! anal fin development + +[Term] +id: GO:0035145 +name: exon-exon junction complex +namespace: cellular_component +def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] +synonym: "EJC" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0035146 +name: tube fusion +namespace: biological_process +def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0048754 ! branching morphogenesis of a tube + +[Term] +id: GO:0035147 +name: branch fusion, open tracheal system +namespace: biological_process +def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] +synonym: "tracheal branch fusion" EXACT [] +is_a: GO:0035146 ! tube fusion +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035148 +name: lumen formation +namespace: biological_process +def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] +synonym: "lumen formation in an anatomical structure" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0035239 ! tube morphogenesis + +[Term] +id: GO:0035149 +name: lumen formation, open tracheal system +namespace: biological_process +def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] +synonym: "tracheal lumen formation" EXACT [] +is_a: GO:0035148 ! lumen formation +is_a: GO:0035152 ! regulation of tube architecture, open tracheal system + +[Term] +id: GO:0035150 +name: regulation of tube size +namespace: biological_process +def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0035151 +name: regulation of tube size, open tracheal system +namespace: biological_process +def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] +synonym: "regulation of tracheal tube size" EXACT [] +is_a: GO:0035150 ! regulation of tube size +is_a: GO:0035152 ! regulation of tube architecture, open tracheal system + +[Term] +id: GO:0035152 +name: regulation of tube architecture, open tracheal system +namespace: biological_process +def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] +synonym: "regulation of tracheal tube architecture" EXACT [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035153 +name: epithelial cell type specification, open tracheal system +namespace: biological_process +def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] +synonym: "tracheal cell type specification" BROAD [] +synonym: "tracheal epithelial cell type specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035154 +name: terminal cell fate specification, open tracheal system +namespace: biological_process +def: "Process by which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] +synonym: "terminal cell fate specification" EXACT [] +is_a: GO:0035153 ! epithelial cell type specification, open tracheal system + +[Term] +id: GO:0035155 +name: negative regulation of terminal cell fate specification, open tracheal system +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581] +synonym: "down regulation of terminal cell fate specification" EXACT [] +synonym: "down-regulation of terminal cell fate specification" EXACT [] +synonym: "downregulation of terminal cell fate specification" EXACT [] +synonym: "inhibition of terminal cell fate specification" NARROW [] +synonym: "negative regulation of terminal cell fate specification" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system + +[Term] +id: GO:0035156 +name: fusion cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940] +is_a: GO:0035153 ! epithelial cell type specification, open tracheal system + +[Term] +id: GO:0035157 +name: negative regulation of fusion cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581] +synonym: "down regulation of fusion cell fate specification" EXACT [] +synonym: "down-regulation of fusion cell fate specification" EXACT [] +synonym: "downregulation of fusion cell fate specification" EXACT [] +synonym: "inhibition of fusion cell fate specification" NARROW [] +is_a: GO:0009996 ! negative regulation of cell fate specification +relationship: negatively_regulates GO:0035156 ! fusion cell fate specification + +[Term] +id: GO:0035158 +name: regulation of tube diameter, open tracheal system +namespace: biological_process +def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] +synonym: "regulation of tracheal tube diameter" EXACT [] +synonym: "tracheal tube dilation" NARROW [] +synonym: "tracheal tube expansion" NARROW [] +is_a: GO:0035296 ! regulation of tube diameter +relationship: part_of GO:0035151 ! regulation of tube size, open tracheal system + +[Term] +id: GO:0035159 +name: regulation of tube length, open tracheal system +namespace: biological_process +def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] +synonym: "regulation of tracheal tube length" EXACT [] +synonym: "tracheal tube elongation" NARROW [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0035151 ! regulation of tube size, open tracheal system + +[Term] +id: GO:0035160 +name: maintenance of epithelial integrity, open tracheal system +namespace: biological_process +def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183] +synonym: "maintenance of tracheal epithelial integrity" EXACT [] +is_a: GO:0010669 ! epithelial structure maintenance +is_a: GO:0035152 ! regulation of tube architecture, open tracheal system + +[Term] +id: GO:0035161 +name: imaginal disc lineage restriction +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0007447 ! imaginal disc pattern formation + +[Term] +id: GO:0035162 +name: embryonic hemopoiesis +namespace: biological_process +def: "The stages of blood cell formation that take place within the embryo." [GOC:bf] +synonym: "embryonic haematopoiesis" EXACT [] +synonym: "embryonic haemopoiesis" EXACT [] +synonym: "embryonic hematopoiesis" EXACT [] +is_a: GO:0030097 ! hemopoiesis +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0035163 +name: embryonic hemocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] +synonym: "embryonic arthropod blood cell differentiation" EXACT [] +synonym: "embryonic hemocyte cell differentiation (sensu Arthropoda)" EXACT [] +synonym: "embryonic hemocyte differentiation (sensu Arthropoda)" EXACT [] +is_a: GO:0042386 ! hemocyte differentiation +relationship: part_of GO:0035162 ! embryonic hemopoiesis + +[Term] +id: GO:0035164 +name: embryonic plasmatocyte differentiation +namespace: biological_process +def: "The process whereby an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] +synonym: "embryonic plasmatocyte cell differentiation" EXACT [] +is_a: GO:0035163 ! embryonic hemocyte differentiation +is_a: GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0035165 +name: embryonic crystal cell differentiation +namespace: biological_process +def: "The process whereby an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] +is_a: GO:0035163 ! embryonic hemocyte differentiation +is_a: GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0035166 +name: post-embryonic hemopoiesis +namespace: biological_process +def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf] +synonym: "post-embryonic haemopoiesis" EXACT [] +is_a: GO:0030097 ! hemopoiesis +is_a: GO:0048569 ! post-embryonic organ development +relationship: part_of GO:0009791 ! post-embryonic development + +[Term] +id: GO:0035167 +name: larval lymph gland hemopoiesis +namespace: biological_process +def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] +synonym: "larval lymph gland haematopoiesis" EXACT [] +synonym: "larval lymph gland haemopoiesis" EXACT [] +synonym: "larval lymph gland hematopoiesis" EXACT [] +synonym: "lymph gland haemopoiesis (sensu Arthropoda)" EXACT [] +synonym: "lymph gland hemopoiesis (sensu Arthropoda)" EXACT [] +is_a: GO:0035166 ! post-embryonic hemopoiesis +relationship: part_of GO:0002164 ! larval development +relationship: part_of GO:0048542 ! lymph gland development + +[Term] +id: GO:0035168 +name: larval lymph gland hemocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] +synonym: "larval lymph gland arthropod blood cell differentiation" EXACT [] +synonym: "lymph gland hemocyte cell differentiation (sensu Arthropoda)" EXACT [] +synonym: "lymph gland hemocyte differentiation (sensu Arthropoda)" EXACT [] +is_a: GO:0042386 ! hemocyte differentiation +relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis + +[Term] +id: GO:0035169 +name: lymph gland plasmatocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] +synonym: "lymph gland plasmatocyte cell differentiation" EXACT [] +is_a: GO:0035168 ! larval lymph gland hemocyte differentiation +is_a: GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0035170 +name: lymph gland crystal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] +is_a: GO:0035168 ! larval lymph gland hemocyte differentiation +is_a: GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0035171 +name: lamellocyte differentiation +namespace: biological_process +def: "The process by which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] +synonym: "lamellocyte cell differentiation" EXACT [] +is_a: GO:0035168 ! larval lymph gland hemocyte differentiation + +[Term] +id: GO:0035172 +name: hemocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "arthropod blood cell proliferation" EXACT [] +synonym: "hemocyte proliferation (sensu Arthropoda)" EXACT [] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0035173 +name: histone kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0035174 +name: histone serine kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] +synonym: "histone-serine kinase activity" EXACT [] +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0035175 +name: histone serine kinase activity (H3-S10 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176] +synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT [] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0035176 +name: social behavior +namespace: biological_process +def: "Behavior that occurs predominantly, or only, in individuals that are part of a group." [PMID:12848939] +synonym: "cooperative behavior" RELATED [] +synonym: "social behaviour" EXACT [] +is_a: GO:0051705 ! behavioral interaction between organisms + +[Term] +id: GO:0035177 +name: larval foraging behavior +namespace: biological_process +def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] +synonym: "larval foraging behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior +is_a: GO:0030536 ! larval feeding behavior + +[Term] +id: GO:0035178 +name: turning behavior +namespace: biological_process +def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478] +synonym: "turning behaviour" EXACT [] +is_a: GO:0007626 ! locomotory behavior + +[Term] +id: GO:0035179 +name: larval turning behavior +namespace: biological_process +def: "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478] +synonym: "larval turning behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior +is_a: GO:0035178 ! turning behavior + +[Term] +id: GO:0035180 +name: larval wandering behavior +namespace: biological_process +def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960] +synonym: "larval wandering behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior + +[Term] +id: GO:0035181 +name: larval burrowing behavior +namespace: biological_process +def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939] +synonym: "larval burrowing behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior + +[Term] +id: GO:0035182 +name: germline ring canal outer rim +namespace: cellular_component +def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006] +comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'. +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0045172 ! germline ring canal + +[Term] +id: GO:0035183 +name: germline ring canal inner rim +namespace: cellular_component +def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] +comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'. +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0045172 ! germline ring canal + +[Term] +id: GO:0035184 +name: histone threonine kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf] +synonym: "histone-threonine kinase activity" EXACT [] +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0035185 +name: preblastoderm mitotic cell cycle +namespace: biological_process +def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238] +is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis +is_a: GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0035186 +name: syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] +is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis +is_a: GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0035187 +name: hatching behavior +namespace: biological_process +def: "The specific actions or reactions of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [PMID:10436051] +synonym: "hatching behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0035188 ! hatching + +[Term] +id: GO:0035188 +name: hatching +namespace: biological_process +def: "The emergence of an organism from a protective structure." [GOC:isa_complete, ISBN:0198612001] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0035189 +name: Rb-E2F complex +namespace: cellular_component +def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] +synonym: "retinoblastoma-E2F complex" EXACT [] +is_a: GO:0005667 ! transcription factor complex + +[Term] +id: GO:0035190 +name: syncytial nuclear migration +namespace: biological_process +def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0035191 +name: nuclear axial expansion +namespace: biological_process +def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839] +synonym: "nuclear distribution along anterior-posterior axis" EXACT [] +synonym: "nucleus distribution along anterior-posterior axis" EXACT [] +is_a: GO:0035190 ! syncytial nuclear migration + +[Term] +id: GO:0035192 +name: nuclear cortical migration +namespace: biological_process +def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839] +is_a: GO:0035190 ! syncytial nuclear migration + +[Term] +id: GO:0035193 +name: larval central nervous system remodeling +namespace: biological_process +def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult." [GOC:sensu, PMID:9647692] +synonym: "central nervous system metamorphosis" EXACT [] +synonym: "central nervous system remodeling (sensu Insecta)" EXACT [] +synonym: "CNS metamorphosis" EXACT [] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0002165 ! instar larval or pupal development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0035194 +name: posttranscriptional gene silencing by RNA +namespace: biological_process +def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283] +synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] +synonym: "sense-PTGS" RELATED [] +is_a: GO:0016441 ! posttranscriptional gene silencing +is_a: GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0035195 +name: gene silencing by miRNA +namespace: biological_process +def: "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [PMID:14744438, PMID:15066275, PMID:15066283] +synonym: "microRNA-mediated gene silencing" EXACT [] +synonym: "miRNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0035194 ! posttranscriptional gene silencing by RNA + +[Term] +id: GO:0035196 +name: gene silencing by miRNA, production of miRNAs +namespace: biological_process +alt_id: GO:0030918 +def: "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283] +synonym: "microRNA biogenesis" RELATED [GOC:tb] +synonym: "microRNA biosynthesis" RELATED [] +synonym: "microRNA biosynthetic process" RELATED [] +synonym: "microRNA metabolic process" RELATED [] +synonym: "microRNA metabolism" RELATED [] +synonym: "microRNA processing" BROAD [] +synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT [] +synonym: "miRNA biogenesis" RELATED [GOC:tb] +synonym: "miRNA processing" EXACT [] +synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031050 ! dsRNA fragmentation +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035197 +name: siRNA binding +namespace: molecular_function +def: "Interacting selectively with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] +synonym: "small interfering RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0035198 +name: miRNA binding +namespace: molecular_function +def: "Interacting selectively with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283] +synonym: "microRNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0035199 +name: salt aversion +namespace: biological_process +def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] +synonym: "behavioral response to salt" BROAD [] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0035200 +name: leg disc anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf] +is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc +is_a: GO:0035223 ! leg disc pattern formation + +[Term] +id: GO:0035201 +name: leg disc anterior/posterior lineage restriction +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf] +is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc +relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation + +[Term] +id: GO:0035202 +name: sac formation, open tracheal system +namespace: biological_process +def: "Formation of the tracheal sacs, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal sacs arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584] +synonym: "tracheal placode invagination" RELATED [] +synonym: "tracheal sac formation (sensu Insecta)" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035203 +name: regulation of lamellocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] +is_a: GO:0045610 ! regulation of hemocyte differentiation +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0035171 ! lamellocyte differentiation + +[Term] +id: GO:0035204 +name: negative regulation of lamellocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] +synonym: "down regulation of lamellocyte differentiation" EXACT [] +synonym: "down-regulation of lamellocyte differentiation" EXACT [] +synonym: "downregulation of lamellocyte differentiation" EXACT [] +synonym: "inhibition of lamellocyte differentiation" NARROW [] +is_a: GO:0035203 ! regulation of lamellocyte differentiation +is_a: GO:0045611 ! negative regulation of hemocyte differentiation +relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation + +[Term] +id: GO:0035205 +name: positive regulation of lamellocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] +synonym: "activation of lamellocyte differentiation" NARROW [] +synonym: "stimulation of lamellocyte differentiation" NARROW [] +synonym: "up regulation of lamellocyte differentiation" EXACT [] +synonym: "up-regulation of lamellocyte differentiation" EXACT [] +synonym: "upregulation of lamellocyte differentiation" EXACT [] +is_a: GO:0035203 ! regulation of lamellocyte differentiation +is_a: GO:0045612 ! positive regulation of hemocyte differentiation +relationship: positively_regulates GO:0035171 ! lamellocyte differentiation + +[Term] +id: GO:0035206 +name: regulation of hemocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "regulation of arthropod blood cell proliferation" EXACT [] +synonym: "regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0042127 ! regulation of cell proliferation +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0035172 ! hemocyte proliferation + +[Term] +id: GO:0035207 +name: negative regulation of hemocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "down regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +synonym: "down-regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +synonym: "downregulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +synonym: "inhibition of hemocyte proliferation (sensu Arthropoda)" NARROW [] +synonym: "negative regulation of arthropod blood cell proliferation" EXACT [] +synonym: "negative regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0035206 ! regulation of hemocyte proliferation +relationship: negatively_regulates GO:0035172 ! hemocyte proliferation + +[Term] +id: GO:0035208 +name: positive regulation of hemocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "activation of hemocyte proliferation (sensu Arthropoda)" NARROW [] +synonym: "positive regulation of arthropod blood cell proliferation" EXACT [] +synonym: "positive regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +synonym: "stimulation of hemocyte proliferation (sensu Arthropoda)" NARROW [] +synonym: "up regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +synonym: "up-regulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +synonym: "upregulation of hemocyte proliferation (sensu Arthropoda)" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0035206 ! regulation of hemocyte proliferation +relationship: positively_regulates GO:0035172 ! hemocyte proliferation + +[Term] +id: GO:0035209 +name: pupal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects which undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu] +synonym: "pupal development (sensu Insecta)" EXACT [] +is_a: GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0035210 +name: prepupal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects which undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm] +comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'. +synonym: "prepupal development (sensu Insecta)" EXACT [] +is_a: GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0035211 +name: spermathecum morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] +comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'. +is_a: GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0035212 +name: cell competition in a multicellular organism +namespace: biological_process +def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. As in, but not restricted to, animals (Metazoa, ncbi_taxonomy_id:33208)." [GOC:bf, PMID:1116643, PMID:15066286] +synonym: "cell competition (sensu Metazoa)" EXACT [] +is_a: GO:0009987 ! cellular process +is_a: GO:0040008 ! regulation of growth +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0035213 +name: clypeo-labral disc development +namespace: biological_process +def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238] +synonym: "development of structures derived from the clypeo-labral disc" EXACT [] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035214 +name: eye-antennal disc development +namespace: biological_process +def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035215 +name: genital disc development +namespace: biological_process +def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035216 +name: haltere disc development +namespace: biological_process +def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035217 +name: labial disc development +namespace: biological_process +def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035218 +name: leg disc development +namespace: biological_process +def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035219 +name: prothoracic disc development +namespace: biological_process +def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035220 +name: wing disc development +namespace: biological_process +def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035221 +name: genital disc pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf] +is_a: GO:0007447 ! imaginal disc pattern formation +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0035222 +name: wing disc pattern formation +namespace: biological_process +def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] +is_a: GO:0007447 ! imaginal disc pattern formation +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0035223 +name: leg disc pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf] +is_a: GO:0007447 ! imaginal disc pattern formation +relationship: part_of GO:0035218 ! leg disc development + +[Term] +id: GO:0035224 +name: genital disc anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318] +is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc +is_a: GO:0035221 ! genital disc pattern formation + +[Term] +id: GO:0035225 +name: determination of genital disc primordium +namespace: biological_process +def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] +is_a: GO:0007445 ! determination of imaginal disc primordium +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0035226 +name: glutamate-cysteine ligase catalytic subunit binding +namespace: molecular_function +def: "Interacting selectively with the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0035227 +name: regulation of glutamate-cysteine ligase activity +namespace: biological_process +def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf] +subset: gosubset_prok +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0035228 +name: negative regulation of glutamate-cysteine ligase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf] +subset: gosubset_prok +synonym: "down regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "downregulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "inhibition of glutamate-cysteine ligase activity" NARROW [] +is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity +is_a: GO:0051352 ! negative regulation of ligase activity + +[Term] +id: GO:0035229 +name: positive regulation of glutamate-cysteine ligase activity +namespace: biological_process +def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617] +subset: gosubset_prok +synonym: "activation of glutamate-cysteine ligase activity" NARROW [] +synonym: "stimulation of glutamate-cysteine ligase activity" NARROW [] +synonym: "up regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "upregulation of glutamate-cysteine ligase activity" EXACT [] +is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity +is_a: GO:0051351 ! positive regulation of ligase activity + +[Term] +id: GO:0035230 +name: cytoneme +namespace: cellular_component +def: "A long, thin and polarized actin-based extension that projects from a cell and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901] +subset: goslim_pir +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0035231 +name: cytoneme biogenesis +namespace: biological_process +def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901] +is_a: GO:0030031 ! cell projection biogenesis + +[Term] +id: GO:0035232 +name: germ cell attraction +namespace: biological_process +def: "The directed movement of germ cells from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551] +is_a: GO:0050918 ! positive chemotaxis +is_a: GO:0060326 ! cell chemotaxis +relationship: part_of GO:0008354 ! germ cell migration + +[Term] +id: GO:0035233 +name: germ cell repulsion +namespace: biological_process +def: "The directed movement of germ cells from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551] +is_a: GO:0050919 ! negative chemotaxis +is_a: GO:0060326 ! cell chemotaxis +relationship: part_of GO:0008354 ! germ cell migration + +[Term] +id: GO:0035234 +name: germ cell programmed cell death +namespace: biological_process +def: "Programmed cell death of errant germ line cells that are outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] +synonym: "programmed cell death of germ cells" EXACT [] +synonym: "programmed cell death, germ cells" EXACT [] +is_a: GO:0010623 ! developmental programmed cell death +relationship: part_of GO:0008354 ! germ cell migration + +[Term] +id: GO:0035235 +name: ionotropic glutamate receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ionotropic glutamate receptor signalling pathway" EXACT [] +is_a: GO:0007215 ! glutamate signaling pathway + +[Term] +id: GO:0035236 +name: proctolin receptor activity +namespace: molecular_function +def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0035237 +name: corazonin receptor activity +namespace: molecular_function +def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0035238 +name: vitamin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606] +subset: gosubset_prok +synonym: "vitamin A anabolism" EXACT [] +synonym: "vitamin A biosynthesis" EXACT [] +synonym: "vitamin A formation" EXACT [] +synonym: "vitamin A synthesis" EXACT [] +is_a: GO:0006776 ! vitamin A metabolic process +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process + +[Term] +id: GO:0035239 +name: tube morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0035295 ! tube development + +[Term] +id: GO:0035240 +name: dopamine binding +namespace: molecular_function +def: "Interacting selectively with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0035241 +name: protein-arginine omega-N monomethyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue." [PMID:14705965, RESID:AA0069] +xref: RESID:AA0069 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0035242 +name: protein-arginine omega-N asymmetric methyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069] +comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. +synonym: "type I PRMT activity" RELATED [] +synonym: "type I protein arginine methyltransferase activity" RELATED [] +xref: RESID:AA0068 +xref: RESID:AA0069 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0035243 +name: protein-arginine omega-N symmetric methyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [PMID:14705965, RESID:AA0067, RESID:AA0069] +comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'. +synonym: "type II PRMT activity" RELATED [] +synonym: "type II protein arginine methyltransferase activity" RELATED [] +xref: RESID:AA0067 +xref: RESID:AA0069 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0035244 +name: peptidyl-arginine C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf] +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0035245 +name: peptidyl-arginine C-methylation +namespace: biological_process +def: "The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf] +subset: gosubset_prok +is_a: GO:0018216 ! peptidyl-arginine methylation + +[Term] +id: GO:0035246 +name: peptidyl-arginine N-methylation +namespace: biological_process +def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf] +subset: gosubset_prok +is_a: GO:0018216 ! peptidyl-arginine methylation + +[Term] +id: GO:0035247 +name: peptidyl-arginine omega-N-methylation +namespace: biological_process +def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069] +subset: gosubset_prok +xref: RESID:AA0067 +xref: RESID:AA0068 +xref: RESID:AA0069 +is_a: GO:0035246 ! peptidyl-arginine N-methylation + +[Term] +id: GO:0035248 +name: alpha-1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] +synonym: "alpha-1,4-GalNAc transferase activity" EXACT [] +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0035249 +name: synaptic transmission, glutamatergic +namespace: biological_process +def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv] +is_a: GO:0007270 ! nerve-nerve synaptic transmission + +[Term] +id: GO:0035250 +name: UDP-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] +subset: gosubset_prok +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0035251 +name: UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] +subset: gosubset_prok +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0035252 +name: UDP-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0042285 ! xylosyltransferase activity + +[Term] +id: GO:0035253 +name: ciliary rootlet +namespace: cellular_component +def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [PMID:12427867] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044441 ! cilium part + +[Term] +id: GO:0035254 +name: glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with a glutamate receptor." [GOC:bf] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0035255 +name: ionotropic glutamate receptor binding +namespace: molecular_function +def: "Interacting selectively with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0035254 ! glutamate receptor binding + +[Term] +id: GO:0035256 +name: metabotropic glutatmate receptor binding +namespace: molecular_function +def: "Interacting selectively with a metabotropic glutamate receptor. Metabotropic glutamate receptors are G-protein coupled receptors that bind glutamate and exert an effect through the regulation of enzyme activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:9069287] +is_a: GO:0001664 ! G-protein-coupled receptor binding +is_a: GO:0035254 ! glutamate receptor binding + +[Term] +id: GO:0035257 +name: nuclear hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf] +is_a: GO:0051427 ! hormone receptor binding + +[Term] +id: GO:0035258 +name: steroid hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a steroid hormone receptor." [GOC:bf] +is_a: GO:0035257 ! nuclear hormone receptor binding + +[Term] +id: GO:0035259 +name: glucocorticoid receptor binding +namespace: molecular_function +def: "Interacting selectively with a glucocorticoid receptor." [GOC:bf] +is_a: GO:0035258 ! steroid hormone receptor binding + +[Term] +id: GO:0035260 +name: internal genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html] +is_a: GO:0035112 ! genitalia morphogenesis + +[Term] +id: GO:0035261 +name: external genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html] +is_a: GO:0035112 ! genitalia morphogenesis + +[Term] +id: GO:0035262 +name: gonad morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0008406 ! gonad development + +[Term] +id: GO:0035263 +name: genital disc sexually dimorphic development +namespace: biological_process +def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] +is_a: GO:0003006 ! reproductive developmental process +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007548 ! sex differentiation +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0035264 +name: multicellular organism growth +namespace: biological_process +def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] +synonym: "body growth" RELATED [] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0040007 ! growth + +[Term] +id: GO:0035265 +name: organ growth +namespace: biological_process +def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0040007 ! growth + +[Term] +id: GO:0035266 +name: meristem growth +namespace: biological_process +def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048507 ! meristem development + +[Term] +id: GO:0035267 +name: NuA4 histone acetyltransferase complex +namespace: cellular_component +def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] +synonym: "TIP60 histone acetylase complex" EXACT [] +synonym: "TIP60 histone acetyltransferase complex" EXACT [] +is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex + +[Term] +id: GO:0035268 +name: protein amino acid mannosylation +namespace: biological_process +def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf] +subset: gosubset_prok +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0035269 +name: protein amino acid O-linked mannosylation +namespace: biological_process +def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797] +subset: gosubset_prok +is_a: GO:0006493 ! protein amino acid O-linked glycosylation +is_a: GO:0035268 ! protein amino acid mannosylation + +[Term] +id: GO:0035270 +name: endocrine system development +namespace: biological_process +def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, http://encyclopedia.thefreedictionary.com/Endocrine+sytem, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0035271 +name: ring gland development +namespace: biological_process +def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098] +comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799. +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0035272 +name: exocrine system development +namespace: biological_process +def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, http://encyclopedia.thefreedictionary.com/Exocrine+gland, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0035273 +name: phthalate binding +namespace: molecular_function +def: "Interacting selectively with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0035274 +name: diphenyl phthalate binding +namespace: molecular_function +def: "Interacting selectively with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] +synonym: "DPP binding" EXACT [] +is_a: GO:0035273 ! phthalate binding + +[Term] +id: GO:0035275 +name: dibutyl phthalate binding +namespace: molecular_function +def: "Interacting selectively with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] +synonym: "DBP binding" EXACT [] +synonym: "phthalic acid dibutyl ester binding" EXACT [] +is_a: GO:0035273 ! phthalate binding + +[Term] +id: GO:0035276 +name: ethanol binding +namespace: molecular_function +def: "Interacting selectively with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0035277 +name: spiracle morphogenesis, open tracheal system +namespace: biological_process +def: "The process by which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] +synonym: "spiracle morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035278 +name: gene silencing by miRNA, negative regulation of translation +namespace: biological_process +def: "The process by which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554] +synonym: "miRNA-mediated gene silencing, down regulation of translation" EXACT [] +synonym: "miRNA-mediated gene silencing, down-regulation of translation" EXACT [] +synonym: "miRNA-mediated gene silencing, downregulation of translation" EXACT [] +synonym: "miRNA-mediated gene silencing, inhibition of translation" NARROW [] +synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035279 +name: gene silencing by miRNA, mRNA cleavage +namespace: biological_process +def: "The process by which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554] +synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006379 ! mRNA cleavage +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035280 +name: gene silencing by miRNA, miRNA loading onto RISC +namespace: biological_process +def: "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438] +synonym: "miRISC assembly" BROAD [] +synonym: "miRNA-mediated gene silencing, miRNA loading onto RISC" EXACT [GOC:dph, GOC:tb] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035281 +name: pre-microRNA export from nucleus +namespace: biological_process +def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [PMID:14744438] +synonym: "pre-microRNA export from cell nucleus" EXACT [] +synonym: "pre-microRNA export out of nucleus" EXACT [] +synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "pre-microRNA-nucleus export" EXACT [] +is_a: GO:0006405 ! RNA export from nucleus +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035282 +name: segmentation +namespace: biological_process +def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0035283 +name: central nervous system segmentation +namespace: biological_process +def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0035284 +name: brain segmentation +namespace: biological_process +def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0007420 ! brain development +relationship: part_of GO:0035283 ! central nervous system segmentation + +[Term] +id: GO:0035285 +name: appendage segmentation +namespace: biological_process +def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0035107 ! appendage morphogenesis + +[Term] +id: GO:0035286 +name: leg segmentation +namespace: biological_process +def: "Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895] +is_a: GO:0035285 ! appendage segmentation +relationship: part_of GO:0035110 ! leg morphogenesis + +[Term] +id: GO:0035287 +name: head segmentation +namespace: biological_process +def: "Partitioning the head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837] +comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children. +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0035288 +name: anterior head segmentation +namespace: biological_process +def: "Partitioning the head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] +comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children. +synonym: "procephalic segmentation" RELATED [] +is_a: GO:0035287 ! head segmentation + +[Term] +id: GO:0035289 +name: posterior head segmentation +namespace: biological_process +def: "Partitioning the posterior region of the head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] +comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children. +synonym: "gnathal segmentation" RELATED [] +is_a: GO:0035287 ! head segmentation + +[Term] +id: GO:0035290 +name: trunk segmentation +namespace: biological_process +def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0035291 +name: specification of segmental identity, intercalary segment +namespace: biological_process +def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305] +comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035288 ! anterior head segmentation + +[Term] +id: GO:0035292 +name: specification of segmental identity, trunk +namespace: biological_process +def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402] +is_a: GO:0007379 ! segment specification +relationship: part_of GO:0035290 ! trunk segmentation + +[Term] +id: GO:0035293 +name: chitin-based larval cuticle pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle." [GOC:bf, GOC:mtg_sensu] +synonym: "larval cuticle pattern formation (sensu Insecta)" EXACT [] +is_a: GO:0035017 ! cuticle pattern formation +relationship: part_of GO:0008363 ! larval chitin-based cuticle development + +[Term] +id: GO:0035294 +name: determination of wing disc primordium +namespace: biological_process +def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238] +is_a: GO:0007445 ! determination of imaginal disc primordium +is_a: GO:0035220 ! wing disc development + +[Term] +id: GO:0035295 +name: tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0035296 +name: regulation of tube diameter +namespace: biological_process +def: "Ensuring that a tube is the correct width." [GOC:bf] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0035150 ! regulation of tube size + +[Term] +id: GO:0035297 +name: regulation of Malpighian tubule diameter +namespace: biological_process +def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] +is_a: GO:0035296 ! regulation of tube diameter +relationship: part_of GO:0035298 ! regulation of Malpighian tubule size + +[Term] +id: GO:0035298 +name: regulation of Malpighian tubule size +namespace: biological_process +def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf] +is_a: GO:0035150 ! regulation of tube size +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0035299 +name: inositol pentakisphosphate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate." [EC:2.7.1.158] +synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.158] +synonym: "Gsl1p" RELATED [EC:2.7.1.158] +synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] +synonym: "inositol polyphosphate kinase activity" EXACT [EC:2.7.1.158] +synonym: "inositol-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158] +synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" EXACT [EC:2.7.1.158] +synonym: "IP5 2-kinase activity" EXACT [EC:2.7.1.158] +synonym: "Ipk1p" RELATED [EC:2.7.1.158] +xref: EC:2.7.1.158 +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0035300 +name: inositol-1,3,4-trisphosphate 5/6-kinase activity +namespace: molecular_function +def: "Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335] +synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.159] +synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW [] +synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW [] +synonym: "inositol trisphosphate 5/6-kinase activity" EXACT [EC:2.7.1.159] +synonym: "Ins(1,3,4)P3 5/6-kinase activity" EXACT [EC:2.7.1.159] +synonym: "IP56K" RELATED [EC:2.7.1.159] +xref: EC:2.7.1.159 +xref: MetaCyc:2.7.1.133-RXN +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0035301 +name: Hedgehog signaling complex +namespace: cellular_component +def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936] +synonym: "Hedgehog signalling complex" EXACT [] +synonym: "HSC" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0035302 +name: ecdysteroid 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15350618] +comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol). +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0035303 +name: regulation of dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] +subset: gosubset_prok +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: regulates GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035304 +name: regulation of protein amino acid dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] +subset: gosubset_prok +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0035303 ! regulation of dephosphorylation +relationship: regulates GO:0006470 ! protein amino acid dephosphorylation + +[Term] +id: GO:0035305 +name: negative regulation of dephosphorylation +namespace: biological_process +def: "Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] +subset: gosubset_prok +synonym: "down regulation of dephosphorylation" EXACT [] +synonym: "down-regulation of dephosphorylation" EXACT [] +synonym: "downregulation of dephosphorylation" EXACT [] +synonym: "inhibition of dephosphorylation" NARROW [] +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +relationship: negatively_regulates GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035306 +name: positive regulation of dephosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] +subset: gosubset_prok +synonym: "activation of dephosphorylation" NARROW [] +synonym: "stimulation of dephosphorylation" NARROW [] +synonym: "up regulation of dephosphorylation" EXACT [] +synonym: "up-regulation of dephosphorylation" EXACT [] +synonym: "upregulation of dephosphorylation" EXACT [] +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +relationship: positively_regulates GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035307 +name: positive regulation of protein amino acid dephosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] +subset: gosubset_prok +synonym: "activation of protein amino acid dephosphorylation" NARROW [] +synonym: "stimulation of protein amino acid dephosphorylation" NARROW [] +synonym: "up regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "upregulation of protein amino acid dephosphorylation" EXACT [] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0035304 ! regulation of protein amino acid dephosphorylation +is_a: GO:0035306 ! positive regulation of dephosphorylation +relationship: positively_regulates GO:0006470 ! protein amino acid dephosphorylation + +[Term] +id: GO:0035308 +name: negative regulation of protein amino acid dephosphorylation +namespace: biological_process +def: "Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] +subset: gosubset_prok +synonym: "down regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "downregulation of protein amino acid dephosphorylation" EXACT [] +synonym: "inhibition of protein amino acid dephosphorylation" NARROW [] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0035304 ! regulation of protein amino acid dephosphorylation +is_a: GO:0035305 ! negative regulation of dephosphorylation +relationship: negatively_regulates GO:0006470 ! protein amino acid dephosphorylation + +[Term] +id: GO:0035309 +name: wing and notum subfield formation +namespace: biological_process +def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0035310 +name: notum cell fate specification +namespace: biological_process +def: "Process by which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0035309 ! wing and notum subfield formation + +[Term] +id: GO:0035311 +name: wing cell fate specification +namespace: biological_process +def: "Process by which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0035309 ! wing and notum subfield formation + +[Term] +id: GO:0035312 +name: 5'-3' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684] +is_a: GO:0008409 ! 5'-3' exonuclease activity +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0035313 +name: wound healing, spreading of epidermal cells +namespace: biological_process +def: "The migration of epithelial cells along or through a wound gap to reestablish a continuous epithelium." [GOC:bf, PMID:15269788] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0035314 +name: scab formation +namespace: biological_process +def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0035315 +name: hair cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf] +is_a: GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0035316 +name: non-sensory hair organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] +comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'. +synonym: "hair organization and biogenesis (sensu Insecta)" EXACT [] +synonym: "non-sensory hair organization and biogenesis" EXACT [] +synonym: "trichome organisation and biogenesis (sensu Insecta)" EXACT [] +synonym: "trichome organization and biogenesis (sensu Insecta)" EXACT [] +is_a: GO:0030030 ! cell projection organization +relationship: part_of GO:0035315 ! hair cell differentiation + +[Term] +id: GO:0035317 +name: imaginal disc-derived wing hair organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] +comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'. +synonym: "imaginal disc-derived wing hair organization and biogenesis" EXACT [] +synonym: "wing hair organisation and biogenesis" EXACT [] +synonym: "wing hair organization and biogenesis" EXACT [] +synonym: "wing trichome organization and biogenesis (sensu Insecta)" EXACT [] +is_a: GO:0035316 ! non-sensory hair organization +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0035318 +name: imaginal disc-derived wing hair outgrowth +namespace: biological_process +def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551] +synonym: "wing hair outgrowth" EXACT [] +synonym: "wing prehair outgrowth" RELATED [] +is_a: GO:0030030 ! cell projection organization +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0035319 +name: imaginal disc-derived wing hair elongation +namespace: biological_process +def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234] +synonym: "wing hair elongation" EXACT [] +synonym: "wing prehair extension" RELATED [] +is_a: GO:0030030 ! cell projection organization +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0035320 +name: imaginal disc-derived wing hair site selection +namespace: biological_process +def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] +synonym: "prehair localization" RELATED [] +synonym: "wing hair site selection" EXACT [] +is_a: GO:0022606 ! establishment of proximal/distal cell polarity +relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation + +[Term] +id: GO:0035321 +name: maintenance of imaginal disc-derived wing hair orientation +namespace: biological_process +def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220] +synonym: "maintenance of wing hair orientation" EXACT [] +is_a: GO:0009954 ! proximal/distal pattern formation +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0040001 +name: establishment of mitotic spindle localization +namespace: biological_process +alt_id: GO:0018986 +alt_id: GO:0030605 +alt_id: GO:0030606 +alt_id: GO:0030608 +alt_id: GO:0030610 +def: "The cell cycle process whereby the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] +synonym: "mitotic spindle positioning" EXACT [] +synonym: "mitotic spindle positioning (sensu Fungi)" NARROW [] +synonym: "mitotic spindle positioning (sensu Saccharomyces)" NARROW [] +synonym: "mitotic spindle positioning and orientation (sensu Saccharomyces)" NARROW [] +synonym: "mitotic spindle positioning or orientation" EXACT [] +synonym: "mitotic spindle positioning or orientation (sensu Fungi)" NARROW [] +synonym: "spindle positioning during mitosis" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051293 ! establishment of spindle localization +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0040002 +name: collagen and cuticulin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet." [GOC:mtg_sensu] +synonym: "cuticle anabolism (sensu Nematoda)" EXACT [] +synonym: "cuticle biosynthetic process (sensu Nematoda)" EXACT [] +synonym: "cuticle formation (sensu Nematoda)" EXACT [] +synonym: "cuticle synthesis (sensu Nematoda)" EXACT [] +is_a: GO:0007592 ! protein-based cuticle development + +[Term] +id: GO:0040003 +name: chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet." [GOC:mtg_sensu] +synonym: "cuticle anabolism (sensu Insecta)" EXACT [] +synonym: "cuticle biosynthetic process (sensu Insecta)" EXACT [] +synonym: "cuticle formation (sensu Insecta)" EXACT [] +synonym: "cuticle synthesis (sensu Insecta)" EXACT [] +is_a: GO:0042335 ! cuticle development + +[Term] +id: GO:0040004 +name: collagen and cuticulin-based cuticle attachment to epithelium +namespace: biological_process +def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it." [GOC:ems, GOC:mtg_sensu] +synonym: "cuticular attachment to epithelium (sensu Nematoda)" EXACT [] +is_a: GO:0040006 ! protein-based cuticle attachment to epithelium +relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle + +[Term] +id: GO:0040005 +name: chitin-based cuticle attachment to epithelium +namespace: biological_process +def: "Attaching of a chitin-containing cuticle to the epithelium underlying it." [GOC:bf, GOC:mtg_sensu] +synonym: "cuticular attachment to epithelium (sensu Insecta)" EXACT [] +is_a: GO:0040006 ! protein-based cuticle attachment to epithelium +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0040006 +name: protein-based cuticle attachment to epithelium +namespace: biological_process +def: "Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu] +synonym: "cuticular attachment to epithelium (sensu Protostomia and Nematoda)" RELATED [] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle + +[Term] +id: GO:0040007 +name: growth +namespace: biological_process +def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] +comment: See also the biological process term 'cell growth ; GO:0016049'. +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: gosubset_prok +synonym: "growth pattern" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0040008 +name: regulation of growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0040007 ! growth + +[Term] +id: GO:0040009 +name: regulation of growth rate +namespace: biological_process +def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] +comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. +is_a: GO:0040008 ! regulation of growth + +[Term] +id: GO:0040010 +name: positive regulation of growth rate +namespace: biological_process +def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah] +comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. +synonym: "activation of growth rate" NARROW [] +synonym: "stimulation of growth rate" NARROW [] +synonym: "up regulation of growth rate" EXACT [] +synonym: "up-regulation of growth rate" EXACT [] +synonym: "upregulation of growth rate" EXACT [] +is_a: GO:0040009 ! regulation of growth rate +is_a: GO:0045927 ! positive regulation of growth + +[Term] +id: GO:0040011 +name: locomotion +namespace: biological_process +def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0040012 +name: regulation of locomotion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0040011 ! locomotion + +[Term] +id: GO:0040013 +name: negative regulation of locomotion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] +synonym: "down regulation of locomotion" EXACT [] +synonym: "down-regulation of locomotion" EXACT [] +synonym: "downregulation of locomotion" EXACT [] +synonym: "inhibition of locomotion" NARROW [] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0040011 ! locomotion + +[Term] +id: GO:0040014 +name: regulation of multicellular organism growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] +synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0035264 ! multicellular organism growth + +[Term] +id: GO:0040015 +name: negative regulation of multicellular organism growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] +synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040014 ! regulation of multicellular organism growth +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0035264 ! multicellular organism growth + +[Term] +id: GO:0040016 +name: embryonic cleavage +namespace: biological_process +def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0040017 +name: positive regulation of locomotion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] +synonym: "activation of locomotion" NARROW [] +synonym: "stimulation of locomotion" NARROW [] +synonym: "up regulation of locomotion" EXACT [] +synonym: "up-regulation of locomotion" EXACT [] +synonym: "upregulation of locomotion" EXACT [] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0040011 ! locomotion + +[Term] +id: GO:0040018 +name: positive regulation of multicellular organism growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040014 ! regulation of multicellular organism growth +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0035264 ! multicellular organism growth + +[Term] +id: GO:0040019 +name: positive regulation of embryonic development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] +synonym: "activation of embryonic development" NARROW [] +synonym: "stimulation of embryonic development" NARROW [] +synonym: "up regulation of embryonic development" EXACT [] +synonym: "up-regulation of embryonic development" EXACT [] +synonym: "upregulation of embryonic development" EXACT [] +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0009790 ! embryonic development + +[Term] +id: GO:0040020 +name: regulation of meiosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiosis, the process by which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051445 ! regulation of meiotic cell cycle +relationship: regulates GO:0007126 ! meiosis + +[Term] +id: GO:0040021 +name: hermaphrodite germ-line sex determination +namespace: biological_process +alt_id: GO:0042005 +def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems] +synonym: "hermaphrodite germ-line sex determination (sensu Nematoda)" EXACT [] +is_a: GO:0018992 ! germ-line sex determination + +[Term] +id: GO:0040022 +name: feminization of hermaphroditic germ-line +namespace: biological_process +def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems] +synonym: "feminization of hermaphroditic germ-line (sensu Nematoda)" EXACT [] +is_a: GO:0040021 ! hermaphrodite germ-line sex determination + +[Term] +id: GO:0040023 +name: establishment of nucleus localization +namespace: biological_process +def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] +synonym: "establishment of cell nucleus localization" EXACT [] +synonym: "establishment of localization of nucleus" EXACT [] +synonym: "establishment of position of nucleus" EXACT [] +synonym: "nuclear positioning" EXACT [] +synonym: "nucleus positioning" EXACT [] +synonym: "positioning of nucleus" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051647 ! nucleus localization + +[Term] +id: GO:0040024 +name: dauer larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X] +is_a: GO:0002119 ! nematode larval development + +[Term] +id: GO:0040025 +name: vulval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X] +synonym: "vulval development (sensu Nematoda)" EXACT [] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0002119 ! nematode larval development + +[Term] +id: GO:0040026 +name: positive regulation of vulval development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] +synonym: "activation of vulval development (sensu Nematoda)" NARROW [] +synonym: "positive regulation of vulval development (sensu Nematoda)" EXACT [] +synonym: "stimulation of vulval development (sensu Nematoda)" NARROW [] +synonym: "up regulation of vulval development (sensu Nematoda)" EXACT [] +synonym: "up-regulation of vulval development (sensu Nematoda)" EXACT [] +synonym: "upregulation of vulval development (sensu Nematoda)" EXACT [] +is_a: GO:0040028 ! regulation of vulval development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0040025 ! vulval development + +[Term] +id: GO:0040027 +name: negative regulation of vulval development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] +synonym: "down regulation of vulval development (sensu Nematoda)" EXACT [] +synonym: "down-regulation of vulval development (sensu Nematoda)" EXACT [] +synonym: "downregulation of vulval development (sensu Nematoda)" EXACT [] +synonym: "inhibition of vulval development (sensu Nematoda)" NARROW [] +synonym: "negative regulation of vulval development (sensu Nematoda)" EXACT [] +is_a: GO:0040028 ! regulation of vulval development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0040025 ! vulval development + +[Term] +id: GO:0040028 +name: regulation of vulval development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma] +synonym: "regulation of vulval development (sensu Nematoda)" EXACT [] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0040025 ! vulval development + +[Term] +id: GO:0040029 +name: regulation of gene expression, epigenetic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +is_a: GO:0010468 ! regulation of gene expression + +[Term] +id: GO:0040030 +name: regulation of molecular function, epigenetic +namespace: biological_process +def: "Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551] +synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040029 ! regulation of gene expression, epigenetic +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0040031 +name: snRNA modification +namespace: biological_process +def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl] +is_a: GO:0009451 ! RNA modification +is_a: GO:0016073 ! snRNA metabolic process + +[Term] +id: GO:0040032 +name: post-embryonic body morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the post-embryonic soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888] +comment: Note that this term was 'body morphogenesis (sensu Nematoda)'. +is_a: GO:0009886 ! post-embryonic morphogenesis +is_a: GO:0010171 ! body morphogenesis + +[Term] +id: GO:0040033 +name: negative regulation of translation, ncRNA-mediated +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb] +synonym: "down regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "down-regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "downregulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "inhibition of mRNA translation, ncRNA-mediated" NARROW [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0045974 ! regulation of translation, ncRNA-mediated + +[Term] +id: GO:0040034 +name: regulation of development, heterochronic +namespace: biological_process +def: "Controlling the timing and/or rate of a developmental event." [PMID:9442909] +synonym: "developmental timing" RELATED [] +synonym: "heterochronic regulation of development" EXACT [] +synonym: "temporal regulation of development" EXACT [] +is_a: GO:0050793 ! regulation of developmental process + +[Term] +id: GO:0040035 +name: hermaphrodite genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888] +is_a: GO:0048806 ! genitalia development + +[Term] +id: GO:0040036 +name: regulation of fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "regulation of FGF receptor signaling pathway" EXACT [] +synonym: "regulation of FGF receptor signalling pathway" EXACT [] +synonym: "regulation of FGFR signaling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway + +[Term] +id: GO:0040037 +name: negative regulation of fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of FGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of FGF receptor signalling pathway" EXACT [] +synonym: "negative regulation of FGFR signaling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway +relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway + +[Term] +id: GO:0040038 +name: polar body extrusion after meiotic divisions +namespace: biological_process +def: "The cell cycle process whereby two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0033206 ! cytokinesis after meiosis +relationship: part_of GO:0007143 ! female meiosis + +[Term] +id: GO:0040039 +name: inductive cell migration +namespace: biological_process +def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0040040 +name: thermosensory behavior +namespace: biological_process +def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems] +synonym: "behavioral response to temperature stimulus" EXACT [] +synonym: "behavioural response to temperature stimulus" EXACT [] +synonym: "thermosensory behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0042000 +name: translocation of peptides or proteins into host +namespace: biological_process +def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044417 ! translocation of molecules into host +is_a: GO:0051808 ! translocation of peptides or proteins into other organism during symbiotic interaction + +[Term] +id: GO:0042001 +name: hermaphrodite somatic sex determination +namespace: biological_process +alt_id: GO:0042002 +def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma." [GOC:ems] +synonym: "hermaphrodite somatic sex determination (sensu Nematoda)" EXACT [] +is_a: GO:0018993 ! somatic sex determination + +[Term] +id: GO:0042003 +name: masculinization of hermaphrodite soma +namespace: biological_process +def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma." [GOC:ems] +synonym: "masculinization of hermaphrodite soma (sensu Nematoda)" EXACT [] +is_a: GO:0042001 ! hermaphrodite somatic sex determination + +[Term] +id: GO:0042004 +name: feminization of hermaphrodite soma +namespace: biological_process +def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma." [GOC:ems] +synonym: "feminization of hermaphrodite soma (sensu Nematoda)" EXACT [] +is_a: GO:0042001 ! hermaphrodite somatic sex determination + +[Term] +id: GO:0042006 +name: masculinization of hermaphroditic germ-line +namespace: biological_process +def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems] +synonym: "masculinization of hermaphroditic germ-line (sensu Nematoda)" EXACT [] +is_a: GO:0040021 ! hermaphrodite germ-line sex determination + +[Term] +id: GO:0042007 +name: interleukin-18 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-18." [GOC:jl] +synonym: "IL-18 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042008 +name: interleukin-18 receptor activity +namespace: molecular_function +def: "Combining with interleukin-18 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-18R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042007 ! interleukin-18 binding + +[Term] +id: GO:0042009 +name: interleukin-15 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-15." [GOC:jl] +synonym: "IL-15 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042010 +name: interleukin-15 receptor activity +namespace: molecular_function +def: "Combining with interleukin-15 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-15R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042009 ! interleukin-15 binding + +[Term] +id: GO:0042011 +name: interleukin-16 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-16." [GOC:jl] +synonym: "IL-16 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042012 +name: interleukin-16 receptor activity +namespace: molecular_function +def: "Combining with interleukin-16 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-16R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042011 ! interleukin-16 binding + +[Term] +id: GO:0042013 +name: interleukin-19 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-19." [GOC:jl] +synonym: "IL-19 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042014 +name: interleukin-19 receptor activity +namespace: molecular_function +def: "Combining with interleukin-19 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-19R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042013 ! interleukin-19 binding + +[Term] +id: GO:0042015 +name: interleukin-20 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-20." [GOC:jl] +synonym: "IL-20 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042016 +name: interleukin-20 receptor activity +namespace: molecular_function +def: "Combining with interleukin-20 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-20R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042015 ! interleukin-20 binding + +[Term] +id: GO:0042017 +name: interleukin-22 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-22." [GOC:jl] +synonym: "IL-22 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042018 +name: interleukin-22 receptor activity +namespace: molecular_function +def: "Combining with interleukin-22 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-22R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042017 ! interleukin-22 binding + +[Term] +id: GO:0042019 +name: interleukin-23 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-23." [GOC:jl] +synonym: "IL-23 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042020 +name: interleukin-23 receptor activity +namespace: molecular_function +def: "Combining with interleukin-23 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-23R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0042019 ! interleukin-23 binding + +[Term] +id: GO:0042021 +name: granulocyte macrophage colony-stimulating factor complex binding +namespace: molecular_function +def: "Interacting selectively with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai] +synonym: "GM-CSF complex binding" EXACT [] +synonym: "GMC-SF complex binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042022 +name: interleukin-12 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-12; comprises an alpha and a beta subunit." [GOC:mah, PMID:10971505] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0042023 +name: DNA endoreduplication +namespace: biological_process +def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. For example, occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl] +comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states. +subset: gosubset_prok +synonym: "DNA endoreplication" EXACT [] +synonym: "DNA re-duplication" EXACT [] +is_a: GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0042024 +name: DNA endoreduplication initiation +namespace: biological_process +def: "The reinitiation of DNA replication within a single cell cycle." [GOC:jl] +subset: gosubset_prok +synonym: "DNA re-replication initiation" EXACT [] +is_a: GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0042025 +name: host cell nucleus +namespace: cellular_component +alt_id: GO:0033649 +def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +subset: gosubset_prok +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +relationship: part_of GO:0043656 ! intracellular region of host + +[Term] +id: GO:0042026 +name: protein refolding +namespace: biological_process +def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] +subset: gosubset_prok +synonym: "heat shock protein activity" RELATED [] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0042027 +name: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8] +comment: This term was made obsolete because it is contains gene product specific characteristics. +is_obsolete: true +consider: GO:0003755 + +[Term] +id: GO:0042028 +name: juglone-sensitive peptidyl-prolyl cis-trans isomerase activity +namespace: molecular_function +synonym: "juglone-sensitive cis-trans proline isomerase activity" EXACT [] +xref: EC:5.2.1.- +is_a: GO:0003755 ! peptidyl-prolyl cis-trans isomerase activity + +[Term] +id: GO:0042029 +name: fibrolase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320] +comment: This term was made obsolete because it represents a gene product. +synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72] +synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72] +synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72] +xref: EC:3.4.24.72 +xref: MetaCyc:3.4.24.72-RXN +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0042030 +name: ATPase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl] +synonym: "adenosinetriphosphatase inhibitor" EXACT [] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0042031 +name: angiotensin-converting enzyme inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl] +synonym: "ACE inhibitor" EXACT [] +synonym: "peptidyl dipeptidase A inhibitor" EXACT [] +is_a: GO:0030414 ! protease inhibitor activity + +[Term] +id: GO:0042033 +name: chemokine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "chemokine anabolism" EXACT [] +synonym: "chemokine biosynthesis" EXACT [] +synonym: "chemokine formation" EXACT [] +synonym: "chemokine synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +is_a: GO:0050755 ! chemokine metabolic process +relationship: part_of GO:0032602 ! chemokine production + +[Term] +id: GO:0042034 +name: peptidyl-lysine esterification +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-L-lysine methyl ester." [RESID:AA0318] +subset: gosubset_prok +xref: RESID:AA0318 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018350 ! protein amino acid esterification + +[Term] +id: GO:0042035 +name: regulation of cytokine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] +synonym: "regulation of cytokine anabolism" EXACT [] +synonym: "regulation of cytokine biosynthesis" EXACT [] +synonym: "regulation of cytokine formation" EXACT [] +synonym: "regulation of cytokine synthesis" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0042089 ! cytokine biosynthetic process + +[Term] +id: GO:0042036 +name: negative regulation of cytokine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] +synonym: "down regulation of cytokine biosynthetic process" EXACT [] +synonym: "down-regulation of cytokine biosynthetic process" EXACT [] +synonym: "downregulation of cytokine biosynthetic process" EXACT [] +synonym: "inhibition of cytokine biosynthetic process" NARROW [] +synonym: "negative regulation of cytokine anabolism" EXACT [] +synonym: "negative regulation of cytokine biosynthesis" EXACT [] +synonym: "negative regulation of cytokine formation" EXACT [] +synonym: "negative regulation of cytokine synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: negatively_regulates GO:0042089 ! cytokine biosynthetic process + +[Term] +id: GO:0042037 +name: peptidyl-histidine methylation, to form pros-methylhistidine +namespace: biological_process +alt_id: GO:0042260 +def: "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073] +subset: gosubset_prok +synonym: "peptidyl-histidine pros-methylation" EXACT [] +xref: RESID:AA0073 +is_a: GO:0018021 ! peptidyl-histidine methylation + +[Term] +id: GO:0042038 +name: peptidyl-histidine methylation, to form tele-methylhistidine +namespace: biological_process +alt_id: GO:0042261 +def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317] +subset: gosubset_prok +synonym: "peptidyl-histidine tele-methylation" EXACT [] +xref: RESID:AA0317 +is_a: GO:0018021 ! peptidyl-histidine methylation + +[Term] +id: GO:0042039 +name: vanadium incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414] +subset: gosubset_prok +synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0042040 +name: metal incorporation into metallo-molybdopterin complex +namespace: biological_process +def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0042042 +name: tungsten incorporation into tungsten-molybdopterin complex +namespace: biological_process +def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai] +subset: gosubset_prok +is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex + +[Term] +id: GO:0042043 +name: neurexin binding +namespace: molecular_function +alt_id: GO:0019963 +def: "Interacting selectively with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [http://cancerweb.ncl.ac.uk/] +synonym: "neuroligin" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042044 +name: fluid transport +namespace: biological_process +def: "The directed movement of substances that are in liquid form in normal living conditions into, out of, within or between cells." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0042045 +name: epithelial fluid transport +namespace: biological_process +def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] +is_a: GO:0042044 ! fluid transport + +[Term] +id: GO:0042046 +name: W-molybdopterin cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +subset: gosubset_prok +synonym: "Moco metabolic process" BROAD [] +synonym: "Moco metabolism" BROAD [] +synonym: "W-molybdopterin cofactor metabolism" EXACT [] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process + +[Term] +id: GO:0042047 +name: W-molybdopterin cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +subset: gosubset_prok +synonym: "Moco biosynthesis" BROAD [] +synonym: "Moco biosynthetic process" BROAD [] +synonym: "W-molybdopterin cofactor anabolism" EXACT [] +synonym: "W-molybdopterin cofactor biosynthesis" EXACT [] +synonym: "W-molybdopterin cofactor formation" EXACT [] +synonym: "W-molybdopterin cofactor synthesis" EXACT [] +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process +is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process +is_a: GO:0042559 ! pteridine and derivative biosynthetic process + +[Term] +id: GO:0042048 +name: olfactory behavior +namespace: biological_process +def: "The actions or reactions of an organism in response to an odor." [GOC:jic] +synonym: "behavioral response to scent" EXACT [] +synonym: "behavioral response to smell" EXACT [] +synonym: "behavioural response to odour" EXACT [] +synonym: "behavioural response to scent" EXACT [] +synonym: "behavioural response to smell" EXACT [] +synonym: "olfactory behaviour" EXACT [] +is_a: GO:0007635 ! chemosensory behavior + +[Term] +id: GO:0042049 +name: cellular acyl-CoA homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006637 ! acyl-CoA metabolic process +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0042051 +name: compound eye photoreceptor development +namespace: biological_process +def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] +synonym: "adult eye photoreceptor development (sensu Drosophila)" NARROW [] +synonym: "eye photoreceptor development (sensu Endopterygota)" EXACT [] +is_a: GO:0042462 ! eye photoreceptor cell development +relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0042052 +name: rhabdomere development +namespace: biological_process +def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0042053 +name: regulation of dopamine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] +synonym: "regulation of dopamine metabolism" EXACT [] +is_a: GO:0042069 ! regulation of catecholamine metabolic process +relationship: regulates GO:0042417 ! dopamine metabolic process + +[Term] +id: GO:0042054 +name: histone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group (CH3-) to a histone." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008276 ! protein methyltransferase activity + +[Term] +id: GO:0042056 +name: chemoattractant activity +namespace: molecular_function +def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "attractant" BROAD [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0042057 +name: transforming growth factor beta receptor anchoring activity +namespace: molecular_function +def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai] +comment: This term was made obsolete because it represents a combination of process and function information. +synonym: "TGF-beta receptor anchoring activity" EXACT [] +synonym: "TGFbeta receptor anchoring activity" EXACT [] +synonym: "transforming growth factor beta receptor anchor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0005160 +replaced_by: GO:0008104 + +[Term] +id: GO:0042058 +name: regulation of epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "regulation of EGF receptor signaling pathway" EXACT [] +synonym: "regulation of EGF receptor signalling pathway" EXACT [] +synonym: "regulation of EGFR signaling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0042059 +name: negative regulation of epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of EGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of EGF receptor signalling pathway" EXACT [] +synonym: "negative regulation of EGFR signaling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway +relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0042060 +name: wound healing +namespace: biological_process +def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0042062 +name: long-term strengthening of neuromuscular junction +namespace: biological_process +def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GOC:mtg_15jun06_ch] +comment: This term was added by GO_REF:0000021. +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: part_of GO:0008582 ! regulation of synaptic growth at neuromuscular junction + +[Term] +id: GO:0042063 +name: gliogenesis +namespace: biological_process +def: "The process by which glial cells are generated. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jic] +synonym: "glial cell generation" EXACT systematic_synonym [] +is_a: GO:0022008 ! neurogenesis + +[Term] +id: GO:0042064 +name: cell adhesion receptor regulator activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005102 +consider: GO:0030155 + +[Term] +id: GO:0042065 +name: glial cell growth +namespace: biological_process +def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jic] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0042066 +name: perineurial glial growth +namespace: biological_process +is_a: GO:0042065 ! glial cell growth + +[Term] +id: GO:0042067 +name: establishment of ommatidial polarity +namespace: biological_process +def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [PMID:3076112, PMID:3937883] +synonym: "establishment of ommatidial polarity (sensu Endopterygota)" EXACT [] +is_a: GO:0001736 ! establishment of planar polarity +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0042068 +name: regulation of pteridine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of pteridine metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0019889 ! pteridine metabolic process + +[Term] +id: GO:0042069 +name: regulation of catecholamine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of catecholamine metabolism" EXACT [] +is_a: GO:0033238 ! regulation of amine metabolic process +relationship: regulates GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042070 +name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0048127 +def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] +synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of oocyte nucleus localization during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "maintenance of oocyte nucleus position during oocyte axis determination" EXACT [] +synonym: "maintenance of oocyte nucleus position during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" EXACT [] +synonym: "oocyte axis determination, maintenance of oocyte nucleus localization (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, maintenance of oocyte nucleus position" EXACT [] +synonym: "oocyte axis determination, maintenance of oocyte nucleus position (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus anchoring" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus anchoring (sensu Insecta)" EXACT [] +synonym: "oocyte nucleus anchoring during oocyte axis determination" EXACT [] +synonym: "oocyte nucleus anchoring during oocyte axis determination (sensu Insecta)" EXACT [] +is_a: GO:0051658 ! maintenance of nucleus location +relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification + +[Term] +id: GO:0042071 +name: leucokinin receptor activity +namespace: molecular_function +def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, to initiate a change in cell activity." [GOC:mah, PMID:2716741] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0042072 +name: cell adhesion receptor inhibitor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0005102 +consider: GO:0007162 + +[Term] +id: GO:0042073 +name: intraflagellar transport +namespace: biological_process +def: "The directed movement of substances within a flagellum." [GOC:jl] +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0043064 ! flagellum organization + +[Term] +id: GO:0042074 +name: cell migration involved in gastrulation +namespace: biological_process +def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0042075 +name: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide +namespace: biological_process +def: "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] +subset: gosubset_prok +synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] +xref: RESID:AA0310 +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster + +[Term] +id: GO:0042076 +name: protein amino acid phosphate-linked glycosylation +namespace: biological_process +def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424] +subset: gosubset_prok +synonym: "phosphoglycosylation" EXACT [] +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0042077 +name: protein amino acid phosphate-linked glycosylation via serine +namespace: biological_process +subset: gosubset_prok +is_a: GO:0042076 ! protein amino acid phosphate-linked glycosylation + +[Term] +id: GO:0042078 +name: germ-line stem cell division +namespace: biological_process +alt_id: GO:0048131 +def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jic, PMID:2279698] +synonym: "germ-line stem cell renewal" EXACT [] +is_a: GO:0008356 ! asymmetric cell division +is_a: GO:0017145 ! stem cell division +relationship: part_of GO:0007281 ! germ cell development + +[Term] +id: GO:0042079 +name: GPI/GSI anchor metabolic process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +is_obsolete: true +consider: GO:0006505 +consider: GO:0042081 + +[Term] +id: GO:0042080 +name: GPI/GSI anchor biosynthetic process +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +synonym: "GPI/GSI anchor anabolism" EXACT [] +synonym: "GPI/GSI anchor biosynthesis" EXACT [] +synonym: "GPI/GSI anchor formation" EXACT [] +synonym: "GPI/GSI anchor synthesis" EXACT [] +is_obsolete: true +consider: GO:0006506 +consider: GO:0042082 + +[Term] +id: GO:0042081 +name: GSI anchor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators] +subset: gosubset_prok +synonym: "GPI/GSI anchor metabolic process" BROAD [] +synonym: "GPI/GSI anchor metabolism" BROAD [] +synonym: "GSI anchor metabolism" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0042082 +name: GSI anchor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid moiety is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg] +subset: gosubset_prok +synonym: "GPI/GSI anchor biosynthesis" BROAD [] +synonym: "GPI/GSI anchor biosynthetic process" BROAD [] +synonym: "GSI anchor anabolism" EXACT [] +synonym: "GSI anchor biosynthesis" EXACT [] +synonym: "GSI anchor formation" EXACT [] +synonym: "GSI anchor synthesis" EXACT [] +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0042081 ! GSI anchor metabolic process + +[Term] +id: GO:0042083 +name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042084 +name: 5-methyltetrahydrofolate-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042085 +name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042086 +name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042088 +name: T-helper 1 type immune response +namespace: biological_process +def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "Th1 immune response" EXACT [] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0042089 +name: cytokine biosynthetic process +namespace: biological_process +alt_id: GO:0042032 +def: "The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0198599471] +synonym: "cytokine anabolism" EXACT [] +synonym: "cytokine biosynthesis" EXACT [] +synonym: "cytokine formation" EXACT [] +synonym: "cytokine synthesis" EXACT [] +synonym: "induction of cytokines" NARROW [] +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0042107 ! cytokine metabolic process +relationship: part_of GO:0001816 ! cytokine production + +[Term] +id: GO:0042090 +name: interleukin-12 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] +synonym: "IL-12 biosynthesis" EXACT [] +synonym: "IL-12 biosynthetic process" EXACT [] +synonym: "interleukin-12 anabolism" EXACT [] +synonym: "interleukin-12 biosynthesis" EXACT [] +synonym: "interleukin-12 formation" EXACT [] +synonym: "interleukin-12 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0042091 +name: interleukin-10 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] +synonym: "IL-10 biosynthesis" EXACT [] +synonym: "IL-10 biosynthetic process" EXACT [] +synonym: "interleukin-10 anabolism" EXACT [] +synonym: "interleukin-10 biosynthesis" EXACT [] +synonym: "interleukin-10 formation" EXACT [] +synonym: "interleukin-10 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0042092 +name: T-helper 2 type immune response +namespace: biological_process +def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "Th2 immune response" EXACT [] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0042093 +name: T-helper cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc] +is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation during immune response + +[Term] +id: GO:0042094 +name: interleukin-2 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] +synonym: "IL-2 biosynthesis" EXACT [] +synonym: "IL-2 biosynthetic process" EXACT [] +synonym: "interleukin-2 anabolism" EXACT [] +synonym: "interleukin-2 biosynthesis" EXACT [] +synonym: "interleukin-2 formation" EXACT [] +synonym: "interleukin-2 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0042095 +name: interferon-gamma biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] +synonym: "IFN-gamma biosynthesis" EXACT [] +synonym: "IFN-gamma biosynthetic process" EXACT [] +synonym: "interferon type II biosynthesis" EXACT [] +synonym: "interferon type II biosynthetic process" EXACT [] +synonym: "interferon-gamma anabolism" EXACT [] +synonym: "interferon-gamma biosynthesis" EXACT [] +synonym: "interferon-gamma formation" EXACT [] +synonym: "interferon-gamma synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0042096 +name: alpha-beta T cell receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes a receptor type, and not an activity. +is_obsolete: true +consider: GO:0032394 +consider: GO:0032395 +consider: GO:0042605 + +[Term] +id: GO:0042097 +name: interleukin-4 biosynthetic process +namespace: biological_process +alt_id: GO:0042224 +def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] +synonym: "IL-4 biosynthesis" EXACT [] +synonym: "IL-4 biosynthetic process" EXACT [] +synonym: "interleukin-4 anabolism" EXACT [] +synonym: "interleukin-4 biosynthesis" EXACT [] +synonym: "interleukin-4 formation" EXACT [] +synonym: "interleukin-4 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0042098 +name: T cell proliferation +namespace: biological_process +alt_id: GO:0042111 +def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl] +synonym: "T lymphocyte proliferation" EXACT [] +synonym: "T-cell proliferation" EXACT [] +synonym: "T-lymphocyte proliferation" EXACT [] +is_a: GO:0042110 ! T cell activation +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0042099 +name: gamma-delta T cell receptor activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes a receptor type, and not an activity. +is_obsolete: true +consider: GO:0032394 +consider: GO:0032395 +consider: GO:0042605 + +[Term] +id: GO:0042100 +name: B cell proliferation +namespace: biological_process +alt_id: GO:0042114 +def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl] +synonym: "B lymphocyte proliferation" EXACT [] +synonym: "B-cell proliferation" EXACT [] +synonym: "B-lymphocyte proliferation" EXACT [] +is_a: GO:0042113 ! B cell activation +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0042101 +name: T cell receptor complex +namespace: cellular_component +def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] +synonym: "T lymphocyte receptor complex" EXACT [] +synonym: "T-cell receptor complex" EXACT [] +synonym: "T-lymphocyte receptor complex" EXACT [] +synonym: "TCR" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0001772 ! immunological synapse + +[Term] +id: GO:0042102 +name: positive regulation of T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai] +synonym: "activation of T cell proliferation" NARROW [] +synonym: "positive regulation of T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of T cell proliferation" NARROW [] +synonym: "up regulation of T cell proliferation" EXACT [] +synonym: "up-regulation of T cell proliferation" EXACT [] +synonym: "upregulation of T cell proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0050671 ! positive regulation of lymphocyte proliferation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0042098 ! T cell proliferation + +[Term] +id: GO:0042103 +name: positive regulation of T cell homeostatic proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl] +synonym: "activation of T cell homeostatic proliferation" NARROW [] +synonym: "positive regulation of resting T cell proliferation" EXACT [] +synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT [] +synonym: "positive regulation of T-cell homeostatic proliferation" EXACT [] +synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT [] +synonym: "stimulation of T cell homeostatic proliferation" NARROW [] +synonym: "up regulation of T cell homeostatic proliferation" EXACT [] +synonym: "up-regulation of T cell homeostatic proliferation" EXACT [] +synonym: "upregulation of T cell homeostatic proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046013 ! regulation of T cell homeostatic proliferation +relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation + +[Term] +id: GO:0042104 +name: positive regulation of activated T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl] +synonym: "activation of activated T cell proliferation" NARROW [] +synonym: "positive regulation of activated T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of activated T-cell proliferation" EXACT [] +synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of activated T cell proliferation" NARROW [] +synonym: "up regulation of activated T cell proliferation" EXACT [] +synonym: "up-regulation of activated T cell proliferation" EXACT [] +synonym: "upregulation of activated T cell proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046006 ! regulation of activated T cell proliferation +relationship: positively_regulates GO:0050798 ! activated T cell proliferation + +[Term] +id: GO:0042105 +name: alpha-beta T cell receptor complex +namespace: cellular_component +def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] +synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] +synonym: "alpha-beta T-cell receptor complex" EXACT [] +synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] +synonym: "alpha-beta TCR complex" EXACT [] +is_a: GO:0042101 ! T cell receptor complex + +[Term] +id: GO:0042106 +name: gamma-delta T cell receptor complex +namespace: cellular_component +def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"] +synonym: "gamma-delta T lymphocyte receptor complex" EXACT [] +synonym: "gamma-delta T-cell receptor complex" EXACT [] +synonym: "gamma-delta T-lymphocyte receptor complex" EXACT [] +synonym: "gamma-delta TCR complex" EXACT [] +is_a: GO:0042101 ! T cell receptor complex + +[Term] +id: GO:0042107 +name: cytokine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, GOC:go_curators, GOC:mtg_15nov05, ISBN:0198599471] +comment: This term was improved by GO_REF:0000022. It was moved. +synonym: "cytokine metabolism" EXACT [] +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0042108 +name: positive regulation of cytokine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators] +synonym: "activation of cytokine biosynthetic process" NARROW [] +synonym: "positive regulation of cytokine anabolism" EXACT [] +synonym: "positive regulation of cytokine biosynthesis" EXACT [] +synonym: "positive regulation of cytokine formation" EXACT [] +synonym: "positive regulation of cytokine synthesis" EXACT [] +synonym: "stimulation of cytokine biosynthetic process" NARROW [] +synonym: "up regulation of cytokine biosynthetic process" EXACT [] +synonym: "up-regulation of cytokine biosynthetic process" EXACT [] +synonym: "upregulation of cytokine biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: positively_regulates GO:0042089 ! cytokine biosynthetic process + +[Term] +id: GO:0042109 +name: lymphotoxin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] +synonym: "LTA biosynthesis" EXACT [] +synonym: "LTA biosynthetic process" EXACT [] +synonym: "lymphotoxin A anabolism" EXACT [] +synonym: "lymphotoxin A biosynthesis" EXACT [] +synonym: "lymphotoxin A formation" EXACT [] +synonym: "lymphotoxin A synthesis" EXACT [] +synonym: "lymphotoxin-alpha biosynthesis" EXACT [] +synonym: "lymphotoxin-alpha biosynthetic process" EXACT [] +synonym: "TNF-B biosynthesis" EXACT [] +synonym: "TNF-B biosynthetic process" EXACT [] +synonym: "TNF-beta biosynthesis" EXACT [] +synonym: "TNF-beta biosynthetic process" EXACT [] +synonym: "tumor necrosis factor-beta biosynthesis" EXACT [] +synonym: "tumor necrosis factor-beta biosynthetic process" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0042110 +name: T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140] +synonym: "T lymphocyte activation" EXACT [] +synonym: "T-cell activation" EXACT [] +synonym: "T-lymphocyte activation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0042113 +name: B cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140] +synonym: "B lymphocyte activation" EXACT [] +synonym: "B-cell activation" EXACT [] +synonym: "B-lymphocyte activation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0042116 +name: macrophage activation +namespace: biological_process +def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology", PMID:14506301] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0042117 +name: monocyte activation +namespace: biological_process +def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0042118 +name: endothelial cell activation +namespace: biological_process +def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology", PMID:12851652, PMID:14581484] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0042119 +name: neutrophil activation +namespace: biological_process +def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0042120 +name: alginic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alginate metabolic process" EXACT [] +synonym: "alginate metabolism" EXACT [] +synonym: "alginic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0042121 +name: alginic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alginate biosynthesis" EXACT [] +synonym: "alginate biosynthetic process" EXACT [] +synonym: "alginic acid anabolism" EXACT [] +synonym: "alginic acid biosynthesis" EXACT [] +synonym: "alginic acid formation" EXACT [] +synonym: "alginic acid synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0042120 ! alginic acid metabolic process + +[Term] +id: GO:0042122 +name: alginic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alginate catabolic process" EXACT [] +synonym: "alginate catabolism" EXACT [] +synonym: "alginic acid breakdown" EXACT [] +synonym: "alginic acid catabolism" EXACT [] +synonym: "alginic acid degradation" EXACT [] +is_a: GO:0042120 ! alginic acid metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0042123 +name: glucanosyltransferase activity +namespace: molecular_function +def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl] +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0042124 +name: 1,3-beta-glucanosyltransferase activity +namespace: molecular_function +def: "Catalysis of the splitting and linkage of 1,3-beta-glucan molecules, resulting in 1,3-beta-glucan chain elongation." [GOC:jl, PMID:10809732] +is_a: GO:0042123 ! glucanosyltransferase activity + +[Term] +id: GO:0042125 +name: protein amino acid galactosylation +namespace: biological_process +def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0042126 +name: nitrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] +subset: gosubset_prok +synonym: "nitrate metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0042127 +name: regulation of cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] +subset: gosubset_prok +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0008283 ! cell proliferation + +[Term] +id: GO:0042128 +name: nitrate assimilation +namespace: biological_process +def: "The uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "assimilatory nitrate reduction" EXACT [] +xref: MetaCyc:PWY-381 +is_a: GO:0042126 ! nitrate metabolic process + +[Term] +id: GO:0042129 +name: regulation of T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl] +synonym: "regulation of T lymphocyte proliferation" EXACT [] +synonym: "regulation of T-cell proliferation" EXACT [] +synonym: "regulation of T-lymphocyte proliferation" EXACT [] +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0042098 ! T cell proliferation + +[Term] +id: GO:0042130 +name: negative regulation of T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl] +synonym: "down regulation of T cell proliferation" EXACT [] +synonym: "down-regulation of T cell proliferation" EXACT [] +synonym: "downregulation of T cell proliferation" EXACT [] +synonym: "inhibition of T cell proliferation" NARROW [] +synonym: "negative regulation of T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of T-cell proliferation" EXACT [] +synonym: "negative regulation of T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0050672 ! negative regulation of lymphocyte proliferation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0042098 ! T cell proliferation + +[Term] +id: GO:0042131 +name: thiamin phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of thiamin phosphate." [PMID:197075] +synonym: "thiamine phosphate phosphatase activity" EXACT [] +is_a: GO:0003993 ! acid phosphatase activity + +[Term] +id: GO:0042132 +name: fructose 1,6-bisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] +subset: gosubset_prok +synonym: "D-fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.11] +synonym: "D-fructose-1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] +synonym: "FBPase activity" EXACT [EC:3.1.3.11] +synonym: "fructose 1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose 1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose 1,6-diphosphate phosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose bisphosphate phosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose diphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose diphosphate phosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose-1,6-bisphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00] +synonym: "hexose bisphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "hexose diphosphatase activity" EXACT [EC:3.1.3.11] +synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11] +xref: EC:3.1.3.11 +xref: MetaCyc:F16BDEPHOS-RXN +xref: Reactome:9272 +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0042133 +name: neurotransmitter metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +synonym: "neurotransmitter metabolism" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0042134 +name: rRNA primary transcript binding +namespace: molecular_function +def: "Interacting selectively with an unprocessed ribosomal RNA transcript." [GOC:jl] +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0042135 +name: neurotransmitter catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "neurotransmitter breakdown" EXACT [] +synonym: "neurotransmitter catabolism" EXACT [] +synonym: "neurotransmitter degradation" EXACT [] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042136 +name: neurotransmitter biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "neurotransmitter anabolism" EXACT [] +synonym: "neurotransmitter biosynthesis" EXACT [] +synonym: "neurotransmitter biosynthesis and storage" BROAD [] +synonym: "neurotransmitter biosynthetic process and storage" BROAD [] +synonym: "neurotransmitter formation" EXACT [] +synonym: "neurotransmitter synthesis" EXACT [] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042137 +name: sequestering of neurotransmitter +namespace: biological_process +def: "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai] +synonym: "neurotransmitter biosynthesis and storage" RELATED [] +synonym: "neurotransmitter biosynthetic process and storage" RELATED [] +synonym: "neurotransmitter retention" EXACT [] +synonym: "neurotransmitter sequestration" EXACT [] +synonym: "neurotransmitter storage" EXACT [] +synonym: "retention of neurotransmitter" EXACT [] +synonym: "sequestration of neurotransmitter" EXACT [] +synonym: "storage of neurotransmitter" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0051235 ! maintenance of location + +[Term] +id: GO:0042138 +name: meiotic DNA double-strand break formation +namespace: biological_process +def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427] +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0042139 +name: early meiotic recombination nodule assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324] +is_a: GO:0007146 ! meiotic recombination nodule assembly + +[Term] +id: GO:0042140 +name: late meiotic recombination nodule assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324] +is_a: GO:0007146 ! meiotic recombination nodule assembly + +[Term] +id: GO:0042141 +name: mating pheromone exporter +namespace: molecular_function +def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl] +comment: This term was made obsolete because it is too gene product specific. +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0042142 +name: heavy metal chelation +namespace: biological_process +def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +is_obsolete: true +replaced_by: GO:0046911 + +[Term] +id: GO:0042144 +name: vacuole fusion, non-autophagic +namespace: biological_process +alt_id: GO:0042145 +def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl] +synonym: "homotypic vacuole fusion" EXACT [] +synonym: "homotypic vacuole fusion (non-autophagic)" EXACT [] +synonym: "homotypic vacuole fusion, non-autophagic" EXACT [] +synonym: "vacuole fusion (non-autophagic)" EXACT [] +is_a: GO:0006944 ! membrane fusion +is_a: GO:0007033 ! vacuole organization + +[Term] +id: GO:0042147 +name: retrograde transport, endosome to Golgi +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697] +synonym: "retrograde (endosome to Golgi) transport" EXACT [] +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0042148 +name: strand invasion +namespace: biological_process +def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855] +synonym: "D-loop biosynthesis" RELATED [] +synonym: "D-loop formation" RELATED [] +xref: Reactome:76004 +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0042149 +name: cellular response to glucose starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0042150 +name: plasmid recombination +namespace: biological_process +def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0042151 +name: nematocyst +namespace: cellular_component +def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [GOC:jl, UniProtKB:P01533] +synonym: "cnidocyst" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044448 ! cell cortex part + +[Term] +id: GO:0042152 +name: RNA-mediated DNA recombination +namespace: biological_process +def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627] +subset: gosubset_prok +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0042153 +name: RPTP-like protein binding +namespace: molecular_function +def: "Interacting selectively with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl] +synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042156 +name: zinc-mediated transcriptional activator activity +namespace: molecular_function +def: "Initiates or upregulates transcription in the presence of zinc." [GOC:jl] +is_a: GO:0016563 ! transcription activator activity + +[Term] +id: GO:0042157 +name: lipoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipoprotein metabolism" EXACT [] +xref: Reactome:174800 +xref: Reactome:174824 +xref: Reactome:176879 +xref: Reactome:205169 +xref: Reactome:211650 +xref: Reactome:211989 +xref: Reactome:214485 +xref: Reactome:221422 +xref: Reactome:221753 +xref: Reactome:223965 +xref: Reactome:230055 +xref: Reactome:230335 +xref: Reactome:232454 +xref: Reactome:238075 +xref: Reactome:238371 +xref: Reactome:244687 +xref: Reactome:244928 +xref: Reactome:249856 +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0042158 +name: lipoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipoprotein anabolism" EXACT [] +synonym: "lipoprotein biosynthesis" EXACT [] +synonym: "lipoprotein formation" EXACT [] +synonym: "lipoprotein synthesis" EXACT [] +xref: Reactome:174587 +xref: Reactome:174660 +xref: Reactome:174741 +xref: Reactome:174786 +xref: Reactome:205143 +xref: Reactome:205158 +xref: Reactome:209724 +xref: Reactome:209730 +xref: Reactome:214472 +xref: Reactome:223942 +xref: Reactome:228178 +xref: Reactome:232439 +xref: Reactome:236386 +xref: Reactome:240580 +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0042159 +name: lipoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipoprotein breakdown" EXACT [] +synonym: "lipoprotein catabolism" EXACT [] +synonym: "lipoprotein degradation" EXACT [] +xref: Reactome:174690 +xref: Reactome:174739 +xref: Reactome:174757 +xref: Reactome:206333 +xref: Reactome:206339 +xref: Reactome:211149 +xref: Reactome:215887 +xref: Reactome:233508 +is_a: GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0042160 +name: lipoprotein modification +namespace: biological_process +def: "The enzymatic modification of a lipoprotein; any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0042161 +name: lipoprotein oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid moiety." [GOC:mah] +subset: gosubset_prok +is_a: GO:0042160 ! lipoprotein modification + +[Term] +id: GO:0042162 +name: telomeric DNA binding +namespace: molecular_function +def: "Interacting selectively with telomere-associated DNA, usually characterized by highly repetitive sequences." [GOC:jl, ISBN:0321000382] +synonym: "telomere binding" BROAD [] +synonym: "telomeric repeat binding" NARROW [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0042163 +name: interleukin-12 beta subunit binding +namespace: molecular_function +def: "Interacting selectively with the beta subunit of interleukin-12." [GOC:mah] +synonym: "CLMFp40 binding" EXACT [] +synonym: "IL-12B binding" EXACT [] +synonym: "IL-12p40 binding" EXACT [] +synonym: "NKSFp40 binding" EXACT [] +is_a: GO:0019972 ! interleukin-12 binding + +[Term] +id: GO:0042164 +name: interleukin-12 alpha subunit binding +namespace: molecular_function +def: "Interacting selectively with the alpha subunit of interleukin-12." [GOC:mah] +synonym: "CLMFp35 binding" EXACT [] +synonym: "IL-12A binding" EXACT [] +synonym: "IL-12p35 binding" EXACT [] +synonym: "NKSFp35 binding" EXACT [] +is_a: GO:0019972 ! interleukin-12 binding + +[Term] +id: GO:0042165 +name: neurotransmitter binding +namespace: molecular_function +def: "Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0042166 +name: acetylcholine binding +namespace: molecular_function +def: "Interacting selectively with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +is_a: GO:0042165 ! neurotransmitter binding +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0042167 +name: heme catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl] +subset: gosubset_prok +synonym: "haem catabolic process" EXACT [] +synonym: "haem catabolism" EXACT [] +synonym: "heme breakdown" EXACT [] +synonym: "heme catabolism" EXACT [] +synonym: "heme degradation" EXACT [] +is_a: GO:0006787 ! porphyrin catabolic process +is_a: GO:0042168 ! heme metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0042168 +name: heme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653] +subset: gosubset_prok +synonym: "haem metabolic process" EXACT [] +synonym: "haem metabolism" EXACT [] +synonym: "heme metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0042169 +name: SH2 domain binding +namespace: molecular_function +def: "Interacting selectively with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0042170 +name: plastid membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009526 ! plastid envelope + +[Term] +id: GO:0042171 +name: lysophosphatidic acid acyltransferase activity +namespace: molecular_function +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0042173 +name: regulation of sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0042174 +name: negative regulation of sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporulation." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of sporulation" EXACT [] +synonym: "down-regulation of sporulation" EXACT [] +synonym: "downregulation of sporulation" EXACT [] +synonym: "inhibition of sporulation" NARROW [] +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043939 ! negative regulation of sporulation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0042175 +name: nuclear envelope-endoplasmic reticulum network +namespace: cellular_component +def: "The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum." [GOC:jl] +synonym: "NE-ER continuum" EXACT [] +synonym: "NE-ER network" EXACT [] +synonym: "nuclear envelope-endoplasmic reticulum continuum" EXACT [] +synonym: "nuclear envelope-ER network" EXACT [] +is_a: GO:0016020 ! membrane +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0042176 +name: regulation of protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] +subset: gosubset_prok +synonym: "regulation of protein breakdown" EXACT [] +synonym: "regulation of protein catabolism" EXACT [] +synonym: "regulation of protein degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0030163 ! protein catabolic process + +[Term] +id: GO:0042177 +name: negative regulation of protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076] +subset: gosubset_prok +synonym: "down regulation of protein catabolic process" EXACT [] +synonym: "down-regulation of protein catabolic process" EXACT [] +synonym: "downregulation of protein catabolic process" EXACT [] +synonym: "inhibition of protein catabolic process" NARROW [] +synonym: "negative regulation of protein breakdown" EXACT [] +synonym: "negative regulation of protein catabolism" EXACT [] +synonym: "negative regulation of protein degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0030163 ! protein catabolic process + +[Term] +id: GO:0042178 +name: xenobiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:jl] +subset: gosubset_prok +synonym: "xenobiotic breakdown" EXACT [] +synonym: "xenobiotic catabolism" EXACT [] +synonym: "xenobiotic degradation" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042179 +name: nicotine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] +subset: gosubset_prok +synonym: "nicotine anabolism" EXACT [] +synonym: "nicotine biosynthesis" EXACT [] +synonym: "nicotine formation" EXACT [] +synonym: "nicotine synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0018933 ! nicotine metabolic process + +[Term] +id: GO:0042180 +name: cellular ketone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] +subset: goslim_pir +subset: gosubset_prok +synonym: "ketone metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0042181 +name: ketone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] +subset: gosubset_prok +synonym: "ketone anabolism" EXACT [] +synonym: "ketone biosynthesis" EXACT [] +synonym: "ketone formation" EXACT [] +synonym: "ketone synthesis" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042182 +name: ketone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] +subset: gosubset_prok +synonym: "ketone breakdown" EXACT [] +synonym: "ketone catabolism" EXACT [] +synonym: "ketone degradation" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042183 +name: formate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "formate breakdown" EXACT [] +synonym: "formate catabolism" EXACT [] +synonym: "formate degradation" EXACT [] +synonym: "formic acid catabolic process" EXACT [] +synonym: "formic acid catabolism" EXACT [] +is_a: GO:0015942 ! formate metabolic process +is_a: GO:0019754 ! one-carbon compound catabolic process + +[Term] +id: GO:0042184 +name: xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators] +subset: gosubset_prok +synonym: "xylene breakdown" EXACT [] +synonym: "xylene catabolism" EXACT [] +synonym: "xylene degradation" EXACT [] +is_a: GO:0018948 ! xylene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042185 +name: m-xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl] +subset: gosubset_prok +synonym: "m-xylene breakdown" EXACT [] +synonym: "m-xylene catabolism" EXACT [] +synonym: "m-xylene degradation" EXACT [] +synonym: "meta-xylene catabolic process" EXACT [] +synonym: "meta-xylene catabolism" EXACT [] +xref: MetaCyc:PWY-142 +is_a: GO:0018949 ! m-xylene metabolic process +is_a: GO:0042184 ! xylene catabolic process + +[Term] +id: GO:0042186 +name: o-xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +subset: gosubset_prok +synonym: "o-xylene breakdown" EXACT [] +synonym: "o-xylene catabolism" EXACT [] +synonym: "o-xylene degradation" EXACT [] +synonym: "ortho-xylene catabolic process" EXACT [] +synonym: "ortho-xylene catabolism" EXACT [] +is_a: GO:0018950 ! o-xylene metabolic process +is_a: GO:0042184 ! xylene catabolic process + +[Term] +id: GO:0042187 +name: p-xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl] +subset: gosubset_prok +synonym: "p-xylene breakdown" EXACT [] +synonym: "p-xylene catabolism" EXACT [] +synonym: "p-xylene degradation" EXACT [] +synonym: "para-xylene catabolic process" EXACT [] +synonym: "para-xylene catabolism" EXACT [] +is_a: GO:0018951 ! p-xylene metabolic process +is_a: GO:0042184 ! xylene catabolic process + +[Term] +id: GO:0042188 +name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] +subset: gosubset_prok +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT [] +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT [] +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT [] +synonym: "DDT catabolic process" EXACT [] +synonym: "DDT catabolism" EXACT [] +is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process +is_a: GO:0046701 ! insecticide catabolic process + +[Term] +id: GO:0042189 +name: vanillin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] +subset: gosubset_prok +synonym: "vanillic aldehyde biosynthesis" EXACT [] +synonym: "vanillic aldehyde biosynthetic process" EXACT [] +synonym: "vanillin anabolism" EXACT [] +synonym: "vanillin biosynthesis" EXACT [] +synonym: "vanillin formation" EXACT [] +synonym: "vanillin synthesis" EXACT [] +is_a: GO:0018982 ! vanillin metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process + +[Term] +id: GO:0042190 +name: vanillin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] +subset: gosubset_prok +synonym: "vanillic aldehyde catabolic process" EXACT [] +synonym: "vanillic aldehyde catabolism" EXACT [] +synonym: "vanillin breakdown" EXACT [] +synonym: "vanillin catabolism" EXACT [] +synonym: "vanillin degradation" EXACT [] +is_a: GO:0018982 ! vanillin metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0042191 +name: methylmercury metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai] +subset: gosubset_prok +synonym: "methylmercury metabolism" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process + +[Term] +id: GO:0042192 +name: methylmercury biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] +subset: gosubset_prok +synonym: "methylmercury anabolism" EXACT [] +synonym: "methylmercury biosynthesis" EXACT [] +synonym: "methylmercury formation" EXACT [] +synonym: "methylmercury synthesis" EXACT [] +is_a: GO:0042191 ! methylmercury metabolic process +is_a: GO:0046414 ! organomercury biosynthetic process + +[Term] +id: GO:0042193 +name: methylmercury catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] +subset: gosubset_prok +synonym: "methylmercury breakdown" EXACT [] +synonym: "methylmercury catabolism" EXACT [] +synonym: "methylmercury degradation" EXACT [] +is_a: GO:0042191 ! methylmercury metabolic process +is_a: GO:0046413 ! organomercury catabolic process + +[Term] +id: GO:0042194 +name: quinate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "quinate anabolism" EXACT [] +synonym: "quinate biosynthesis" EXACT [] +synonym: "quinate formation" EXACT [] +synonym: "quinate synthesis" EXACT [] +synonym: "quinic acid biosynthesis" EXACT [] +synonym: "quinic acid biosynthetic process" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019630 ! quinate metabolic process + +[Term] +id: GO:0042195 +name: aerobic gallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl] +subset: gosubset_prok +synonym: "aerobic gallate breakdown" EXACT [] +synonym: "aerobic gallate catabolism" EXACT [] +synonym: "aerobic gallate degradation" EXACT [] +synonym: "aerobic gallic acid catabolic process" EXACT [] +synonym: "aerobic gallic acid catabolism" EXACT [] +is_a: GO:0019396 ! gallate catabolic process + +[Term] +id: GO:0042196 +name: chlorinated hydrocarbon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai] +subset: gosubset_prok +synonym: "chlorinated hydrocarbon metabolism" EXACT [] +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0042197 +name: halogenated hydrocarbon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai] +subset: gosubset_prok +synonym: "halogenated hydrocarbon metabolism" EXACT [] +xref: Reactome:207154 +xref: Reactome:216727 +xref: Reactome:76475 +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0042198 +name: nylon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [SP_KW:KW-0549] +subset: gosubset_prok +synonym: "nylon metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0042199 +name: cyanuric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [http://umbbd.ahc.umn.edu/cya/cya_map.html, UM-BBD_pathwayID:cya] +subset: gosubset_prok +synonym: "cyanuric acid metabolism" EXACT [] +is_a: GO:0018965 ! s-triazine compound metabolic process + +[Term] +id: GO:0042200 +name: cyanuric acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [http://umbbd.ahc.umn.edu/cya/cya_map.html, UM-BBD_pathwayID:cya] +subset: gosubset_prok +synonym: "cyanuric acid breakdown" EXACT [] +synonym: "cyanuric acid catabolism" EXACT [] +synonym: "cyanuric acid degradation" EXACT [] +xref: UM-BBD_pathwayID:cya +is_a: GO:0042199 ! cyanuric acid metabolic process +is_a: GO:0042204 ! s-triazine compound catabolic process + +[Term] +id: GO:0042201 +name: N-cyclopropylmelamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [http://umbbd.ahc.umn.edu/cpm/cpm_map.html, UM-BBD_pathwayID:cpm] +subset: gosubset_prok +synonym: "cyromazine metabolic process" EXACT [] +synonym: "cyromazine metabolism" EXACT [] +synonym: "N-cyclopropylmelamine metabolism" EXACT [] +is_a: GO:0018965 ! s-triazine compound metabolic process + +[Term] +id: GO:0042202 +name: N-cyclopropylmelamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [http://umbbd.ahc.umn.edu/cpm/cpm_map.html, UM-BBD_pathwayID:cpm] +subset: gosubset_prok +synonym: "cyromazine catabolic process" EXACT [] +synonym: "cyromazine catabolism" EXACT [] +synonym: "N-cyclopropylmelamine breakdown" EXACT [] +synonym: "N-cyclopropylmelamine catabolism" EXACT [] +synonym: "N-cyclopropylmelamine degradation" EXACT [] +xref: UM-BBD_pathwayID:cpm +is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process +is_a: GO:0042204 ! s-triazine compound catabolic process + +[Term] +id: GO:0042203 +name: toluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators] +subset: gosubset_prok +synonym: "toluene breakdown" EXACT [] +synonym: "toluene catabolism" EXACT [] +synonym: "toluene degradation" EXACT [] +is_a: GO:0018970 ! toluene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042204 +name: s-triazine compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [http://umbbd.ahc.umn.edu/tria/tria_map.html, UM-BBD_pathwayID:tria] +subset: gosubset_prok +synonym: "s-triazine compound breakdown" EXACT [] +synonym: "s-triazine compound catabolism" EXACT [] +synonym: "s-triazine compound degradation" EXACT [] +xref: UM-BBD_pathwayID:tria +is_a: GO:0018965 ! s-triazine compound metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0042205 +name: chlorinated hydrocarbon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai] +subset: gosubset_prok +synonym: "chlorinated hydrocarbon breakdown" EXACT [] +synonym: "chlorinated hydrocarbon catabolism" EXACT [] +synonym: "chlorinated hydrocarbon degradation" EXACT [] +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042206 ! halogenated hydrocarbon catabolic process + +[Term] +id: GO:0042206 +name: halogenated hydrocarbon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it." [GOC:ai] +subset: gosubset_prok +synonym: "halogenated hydrocarbon breakdown" EXACT [] +synonym: "halogenated hydrocarbon catabolism" EXACT [] +synonym: "halogenated hydrocarbon degradation" EXACT [] +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0042207 +name: styrene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl] +subset: gosubset_prok +synonym: "styrene breakdown" EXACT [] +synonym: "styrene catabolism" EXACT [] +synonym: "styrene degradation" EXACT [] +xref: UM-BBD_pathwayID:sty +is_a: GO:0018966 ! styrene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042208 +name: propylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl] +subset: gosubset_prok +synonym: "propylene breakdown" EXACT [] +synonym: "propylene catabolism" EXACT [] +synonym: "propylene degradation" EXACT [] +xref: UM-BBD_pathwayID:pro +is_a: GO:0018964 ! propylene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042209 +name: orcinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl] +subset: gosubset_prok +synonym: "orcin catabolic process" EXACT [] +synonym: "orcin catabolism" EXACT [] +synonym: "orcinol breakdown" EXACT [] +synonym: "orcinol catabolism" EXACT [] +synonym: "orcinol degradation" EXACT [] +xref: UM-BBD_pathwayID:orc +is_a: GO:0018940 ! orcinol metabolic process +is_a: GO:0042203 ! toluene catabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0042210 +name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl] +subset: gosubset_prok +synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT [] +synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT [] +synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT [] +synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0018947 ! anaerobic organosilicon metabolic process +is_a: GO:0046454 ! dimethylsilanediol metabolic process +is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process + +[Term] +id: GO:0042211 +name: dimethylsilanediol catabolic process +namespace: biological_process +def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl] +subset: gosubset_prok +synonym: "catabolic process of DMSD" EXACT [] +synonym: "catabolism of DMSD" EXACT [] +synonym: "degradation of dimethylsilanediol" EXACT [] +synonym: "dimethylsilanediol breakdown" EXACT [] +synonym: "dimethylsilanediol catabolism" EXACT [] +synonym: "dimethylsilanediol degradation" EXACT [] +is_a: GO:0018946 ! aerobic organosilicon metabolic process +is_a: GO:0046454 ! dimethylsilanediol metabolic process +is_a: GO:0046455 ! organosilicon catabolic process + +[Term] +id: GO:0042212 +name: cresol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [http://umbbd.ahc.umn.edu/mcr/mcr_map.html, UM-BBD_pathwayID:mcr] +subset: gosubset_prok +synonym: "cresol metabolism" EXACT [] +synonym: "hydroxytoluene metabolic process" EXACT [] +synonym: "hydroxytoluene metabolism" EXACT [] +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0042213 +name: m-cresol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl] +subset: gosubset_prok +synonym: "3-hydroxytoluene catabolic process" EXACT [] +synonym: "3-hydroxytoluene catabolism" EXACT [] +synonym: "m-cresol breakdown" EXACT [] +synonym: "m-cresol catabolism" EXACT [] +synonym: "m-cresol degradation" EXACT [] +synonym: "meta-cresol catabolic process" EXACT [] +synonym: "meta-cresol catabolism" EXACT [] +xref: MetaCyc:M-CRESOL-DEGRADATION-PWY +xref: UM-BBD_pathwayID:mcr +is_a: GO:0018925 ! m-cresol metabolic process +is_a: GO:0046199 ! cresol catabolic process + +[Term] +id: GO:0042214 +name: terpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "terpene metabolism" EXACT [] +is_a: GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0042215 +name: anaerobic phenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "anaerobic carbolic acid metabolic process" EXACT [] +synonym: "anaerobic carbolic acid metabolism" EXACT [] +synonym: "anaerobic hydroxybenzene metabolic process" EXACT [] +synonym: "anaerobic hydroxybenzene metabolism" EXACT [] +synonym: "anaerobic phenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0042216 +name: phenanthrene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl] +subset: gosubset_prok +synonym: "phenanthrene breakdown" EXACT [] +synonym: "phenanthrene catabolism" EXACT [] +synonym: "phenanthrene degradation" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0018955 ! phenanthrene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042217 +name: 1-aminocyclopropane-1-carboxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] +subset: gosubset_prok +synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT [] +is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0042218 +name: 1-aminocyclopropane-1-carboxylate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] +subset: gosubset_prok +synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT [] +is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process +relationship: part_of GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0042219 +name: amino acid derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] +subset: gosubset_prok +synonym: "amino acid derivative breakdown" EXACT [] +synonym: "amino acid derivative catabolism" EXACT [] +synonym: "amino acid derivative degradation" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042220 +name: response to cocaine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0014073 ! response to tropane +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0042221 +name: response to chemical stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] +subset: goslim_candida +subset: goslim_yeast +subset: gosubset_prok +synonym: "response to chemical substance" EXACT [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0042222 +name: interleukin-1 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "IL-1 biosynthesis" EXACT [] +synonym: "IL-1 biosynthetic process" EXACT [] +synonym: "interleukin-1 anabolism" EXACT [] +synonym: "interleukin-1 biosynthesis" EXACT [] +synonym: "interleukin-1 formation" EXACT [] +synonym: "interleukin-1 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0042223 +name: interleukin-3 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] +synonym: "IL-3 biosynthesis" EXACT [] +synonym: "IL-3 biosynthetic process" EXACT [] +synonym: "interleukin-3 anabolism" EXACT [] +synonym: "interleukin-3 biosynthesis" EXACT [] +synonym: "interleukin-3 formation" EXACT [] +synonym: "interleukin-3 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0042225 +name: interleukin-5 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] +synonym: "IL-5 biosynthesis" EXACT [] +synonym: "IL-5 biosynthetic process" EXACT [] +synonym: "interleukin-5 anabolism" EXACT [] +synonym: "interleukin-5 biosynthesis" EXACT [] +synonym: "interleukin-5 formation" EXACT [] +synonym: "interleukin-5 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0042226 +name: interleukin-6 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] +synonym: "IL-6 biosynthesis" EXACT [] +synonym: "IL-6 biosynthetic process" EXACT [] +synonym: "interleukin-6 anabolism" EXACT [] +synonym: "interleukin-6 biosynthesis" EXACT [] +synonym: "interleukin-6 formation" EXACT [] +synonym: "interleukin-6 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0042227 +name: interleukin-7 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] +synonym: "IL-7 biosynthesis" EXACT [] +synonym: "IL-7 biosynthetic process" EXACT [] +synonym: "interleukin-7 anabolism" EXACT [] +synonym: "interleukin-7 biosynthesis" EXACT [] +synonym: "interleukin-7 formation" EXACT [] +synonym: "interleukin-7 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0042228 +name: interleukin-8 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] +synonym: "IL-8 biosynthesis" EXACT [] +synonym: "IL-8 biosynthetic process" EXACT [] +synonym: "interleukin-8 anabolism" EXACT [] +synonym: "interleukin-8 biosynthesis" EXACT [] +synonym: "interleukin-8 formation" EXACT [] +synonym: "interleukin-8 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0042229 +name: interleukin-9 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] +synonym: "IL-9 biosynthesis" EXACT [] +synonym: "IL-9 biosynthetic process" EXACT [] +synonym: "interleukin-9 anabolism" EXACT [] +synonym: "interleukin-9 biosynthesis" EXACT [] +synonym: "interleukin-9 formation" EXACT [] +synonym: "interleukin-9 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0042230 +name: interleukin-11 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] +synonym: "IL-11 biosynthesis" EXACT [] +synonym: "IL-11 biosynthetic process" EXACT [] +synonym: "interleukin-11 anabolism" EXACT [] +synonym: "interleukin-11 biosynthesis" EXACT [] +synonym: "interleukin-11 formation" EXACT [] +synonym: "interleukin-11 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0042231 +name: interleukin-13 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] +synonym: "IL-13 biosynthesis" EXACT [] +synonym: "IL-13 biosynthetic process" EXACT [] +synonym: "interleukin-13 anabolism" EXACT [] +synonym: "interleukin-13 biosynthesis" EXACT [] +synonym: "interleukin-13 formation" EXACT [] +synonym: "interleukin-13 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0042232 +name: interleukin-14 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] +synonym: "IL-14 biosynthesis" EXACT [] +synonym: "IL-14 biosynthetic process" EXACT [] +synonym: "interleukin-14 anabolism" EXACT [] +synonym: "interleukin-14 biosynthesis" EXACT [] +synonym: "interleukin-14 formation" EXACT [] +synonym: "interleukin-14 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032617 ! interleukin-14 production + +[Term] +id: GO:0042233 +name: interleukin-15 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] +synonym: "IL-15 biosynthesis" EXACT [] +synonym: "IL-15 biosynthetic process" EXACT [] +synonym: "interleukin-15 anabolism" EXACT [] +synonym: "interleukin-15 biosynthesis" EXACT [] +synonym: "interleukin-15 formation" EXACT [] +synonym: "interleukin-15 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0042234 +name: interleukin-16 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] +synonym: "IL-16 biosynthesis" EXACT [] +synonym: "IL-16 biosynthetic process" EXACT [] +synonym: "interleukin-16 anabolism" EXACT [] +synonym: "interleukin-16 biosynthesis" EXACT [] +synonym: "interleukin-16 formation" EXACT [] +synonym: "interleukin-16 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0042235 +name: interleukin-17 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] +synonym: "IL-17 biosynthesis" EXACT [] +synonym: "IL-17 biosynthetic process" EXACT [] +synonym: "interleukin-17 anabolism" EXACT [] +synonym: "interleukin-17 biosynthesis" EXACT [] +synonym: "interleukin-17 formation" EXACT [] +synonym: "interleukin-17 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0042236 +name: interleukin-19 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] +synonym: "IL-19 biosynthesis" EXACT [] +synonym: "IL-19 biosynthetic process" EXACT [] +synonym: "interleukin-19 anabolism" EXACT [] +synonym: "interleukin-19 biosynthesis" EXACT [] +synonym: "interleukin-19 formation" EXACT [] +synonym: "interleukin-19 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0042237 +name: interleukin-20 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] +synonym: "IL-20 biosynthesis" EXACT [] +synonym: "IL-20 biosynthetic process" EXACT [] +synonym: "interleukin-20 anabolism" EXACT [] +synonym: "interleukin-20 biosynthesis" EXACT [] +synonym: "interleukin-20 formation" EXACT [] +synonym: "interleukin-20 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0042238 +name: interleukin-21 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] +synonym: "IL-21 biosynthesis" EXACT [] +synonym: "IL-21 biosynthetic process" EXACT [] +synonym: "interleukin-21 anabolism" EXACT [] +synonym: "interleukin-21 biosynthesis" EXACT [] +synonym: "interleukin-21 formation" EXACT [] +synonym: "interleukin-21 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0042239 +name: interleukin-22 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] +synonym: "IL-22 biosynthesis" EXACT [] +synonym: "IL-22 biosynthetic process" EXACT [] +synonym: "interleukin-22 anabolism" EXACT [] +synonym: "interleukin-22 biosynthesis" EXACT [] +synonym: "interleukin-22 formation" EXACT [] +synonym: "interleukin-22 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0042240 +name: interleukin-23 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] +synonym: "IL-23 biosynthesis" EXACT [] +synonym: "IL-23 biosynthetic process" EXACT [] +synonym: "interleukin-23 anabolism" EXACT [] +synonym: "interleukin-23 biosynthesis" EXACT [] +synonym: "interleukin-23 formation" EXACT [] +synonym: "interleukin-23 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0042241 +name: interleukin-18 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] +synonym: "IL-18 biosynthesis" EXACT [] +synonym: "IL-18 biosynthetic process" EXACT [] +synonym: "interleukin-18 anabolism" EXACT [] +synonym: "interleukin-18 biosynthesis" EXACT [] +synonym: "interleukin-18 formation" EXACT [] +synonym: "interleukin-18 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0042242 +name: cobyrinic acid a,c-diamide synthase activity +namespace: molecular_function +def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209] +comment: Note that this enzyme does not have an EC number yet, as its activity has not been proven experimentally. May need to be moved in the future. +subset: gosubset_prok +synonym: "CobB" NARROW [] +is_a: GO:0004359 ! glutaminase activity + +[Term] +id: GO:0042243 +name: asexual spore wall assembly +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the specialized envelope lying outside the cell membrane of a spore derived from a product of mitosis." [GOC:mah] +subset: gosubset_prok +synonym: "asexual spore wall formation" EXACT [] +synonym: "spore wall assembly (sensu Bacteria)" NARROW [] +is_a: GO:0042244 ! spore wall assembly +relationship: part_of GO:0030436 ! asexual sporulation + +[Term] +id: GO:0042244 +name: spore wall assembly +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] +subset: gosubset_prok +synonym: "spore coat biosynthesis" EXACT [] +synonym: "spore coat biosynthetic process" EXACT [] +synonym: "spore wall formation" EXACT [] +is_a: GO:0007047 ! cell wall organization +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0042245 +name: RNA repair +namespace: biological_process +def: "Any process by which damaged RNA can be repaired." [PMID:11000254, PMID:11070075, SP_KW:KW-0692] +subset: gosubset_prok +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0042246 +name: tissue regeneration +namespace: biological_process +def: "The regrowth of lost or destroyed tissues." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0009888 ! tissue development +is_a: GO:0031099 ! regeneration +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0042247 +name: establishment of polarity of follicular epithelium +namespace: biological_process +def: "The specification and formation of a polarized follicular epithelial sheet." [GOC:bf] +is_a: GO:0001736 ! establishment of planar polarity +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium + +[Term] +id: GO:0042248 +name: maintenance of polarity of follicular epithelium +namespace: biological_process +def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf] +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium + +[Term] +id: GO:0042249 +name: establishment of polarity of embryonic epithelium +namespace: biological_process +def: "The specification and formation of a polarized embryonic epithelial sheet." [GOC:jl] +is_a: GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0042250 +name: maintenance of polarity of embryonic epithelium +namespace: biological_process +def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl] +is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium + +[Term] +id: GO:0042251 +name: maintenance of polarity of larval imaginal disc epithelium +namespace: biological_process +def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl] +is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium + +[Term] +id: GO:0042252 +name: establishment of polarity of larval imaginal disc epithelium +namespace: biological_process +def: "The specification and formation of a polarized larval imaginal disc epithelium." [GOC:jl] +is_a: GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0042253 +name: granulocyte macrophage colony-stimulating factor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "GM-CSF biosynthesis" EXACT [] +synonym: "GM-CSF biosynthetic process" EXACT [] +synonym: "GMC-SF biosynthesis" EXACT [] +synonym: "GMC-SF biosynthetic process" EXACT [] +synonym: "granulocyte macrophage colony-stimulating factor anabolism" EXACT [] +synonym: "granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] +synonym: "granulocyte macrophage colony-stimulating factor formation" EXACT [] +synonym: "granulocyte macrophage colony-stimulating factor synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0042254 +name: ribosome biogenesis +namespace: biological_process +alt_id: GO:0007046 +def: "The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:ma] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "ribosomal chaperone activity" RELATED [] +synonym: "ribosome biogenesis and assembly" EXACT [] +is_a: GO:0006996 ! organelle organization +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis and assembly + +[Term] +id: GO:0042255 +name: ribosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma] +subset: gosubset_prok +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0042256 +name: mature ribosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma] +subset: gosubset_prok +is_a: GO:0042255 ! ribosome assembly + +[Term] +id: GO:0042257 +name: ribosomal subunit assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form ribosomal subunits." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042255 ! ribosome assembly + +[Term] +id: GO:0042258 +name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319] +subset: gosubset_prok +xref: RESID:AA0319 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0042259 +name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine +namespace: biological_process +def: "The posttranslation modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320] +subset: gosubset_prok +synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT [] +xref: RESID:AA0320 +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0042262 +name: DNA protection +namespace: biological_process +def: "Any process by which DNA is protected from damage by, for example, oxidative stress." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0031668 ! cellular response to extracellular stimulus +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0042263 +name: neuropeptide F receptor activity +namespace: molecular_function +def: "Combining with neuropeptide F, an invertebrate neuropeptide thought to play a role in neuroregulation, to initiate a change in cell activity. In many species, neuropeptide F is between 36 and 39 amino acid residues terminating in a phenylalaninamide residue." [GOC:ma] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0042264 +name: peptidyl-aspartic acid hydroxylation +namespace: biological_process +subset: gosubset_prok +synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] +is_a: GO:0018126 ! protein amino acid hydroxylation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0042265 +name: peptidyl-asparagine hydroxylation +namespace: biological_process +subset: gosubset_prok +synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] +is_a: GO:0018126 ! protein amino acid hydroxylation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0042267 +name: natural killer cell mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. +synonym: "killer activity" RELATED [] +synonym: "natural killer cell mediated cell death" EXACT [] +synonym: "natural killer cell mediated cell killing" EXACT [] +synonym: "natural killer cell mediated cytolysis" RELATED [] +synonym: "natural killer-cell mediated cytolysis" RELATED [] +synonym: "NK cell mediated cell death" EXACT [] +synonym: "NK cell mediated cell killing" EXACT [] +synonym: "NK cell mediated cytolysis" RELATED [] +synonym: "NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0002228 ! natural killer cell mediated immunity +is_a: GO:0006917 ! induction of apoptosis + +[Term] +id: GO:0042268 +name: regulation of cytolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl] +subset: gosubset_prok +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0019835 ! cytolysis + +[Term] +id: GO:0042269 +name: regulation of natural killer cell mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of natural killer cell mediated cell death" EXACT [] +synonym: "regulation of natural killer cell mediated cell killing" EXACT [] +synonym: "regulation of natural killer cell mediated cytolysis" RELATED [] +synonym: "regulation of natural killer-cell mediated cytolysis" RELATED [] +synonym: "regulation of NK cell mediated cell death" EXACT [] +synonym: "regulation of NK cell mediated cell killing" EXACT [] +synonym: "regulation of NK cell mediated cytolysis" RELATED [] +synonym: "regulation of NK cell mediated cytotoxicity" RELATED [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0042270 +name: protection from natural killer cell mediated cytotoxicity +namespace: biological_process +def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "protection from natural killer cell mediated cell death" EXACT [] +synonym: "protection from natural killer cell mediated cell killing" EXACT [] +synonym: "protection from natural killer cell mediated cytolysis" RELATED [] +synonym: "protection from NK cell mediated cell death" EXACT [] +synonym: "protection from NK cell mediated cell killing" EXACT [] +synonym: "protection from NK cell mediated cytolysis" RELATED [] +synonym: "protection from NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity + +[Term] +id: GO:0042271 +name: susceptibility to natural killer cell mediated cytotoxicity +namespace: biological_process +def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity. +synonym: "susceptibility to natural killer cell mediated cell death" EXACT [] +synonym: "susceptibility to natural killer cell mediated cell killing" EXACT [] +synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED [] +synonym: "susceptibility to NK cell mediated cell death" EXACT [] +synonym: "susceptibility to NK cell mediated cell killing" EXACT [] +synonym: "susceptibility to NK cell mediated cytolysis" EXACT [] +synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity + +[Term] +id: GO:0042272 +name: nuclear RNA export factor complex +namespace: cellular_component +def: "A complex of NXF1 and NXF2 required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [UniProtKB:Q9U1H9] +synonym: "Mex67-Mtr2 complex" EXACT [] +synonym: "NXF1-NXT1 complex" EXACT [] +synonym: "TAP-p15 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0042273 +name: ribosomal large subunit biogenesis +namespace: biological_process +def: "The formation of the constituents of the large ribosomal subunit, their assembly, and their transport to the sites of protein synthesis." [GOC:jl] +synonym: "ribosomal large subunit biogenesis and assembly" EXACT [] +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis and assembly +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0042274 +name: ribosomal small subunit biogenesis +namespace: biological_process +def: "The formation of the constituents of the small ribosomal subunit, their assembly, and their transport to the sites of protein synthesis." [GOC:jl] +synonym: "ribosomal small subunit biogenesis and assembly" EXACT [] +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis and assembly +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0042275 +name: error-free postreplication DNA repair +namespace: biological_process +def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA without removing the replication-blocking lesions and without increasing the endogenous mutation rate." [GOC:jl, PMID:11459630] +subset: gosubset_prok +synonym: "error-free PRR" EXACT [] +synonym: "error-free replication restart" RELATED [] +synonym: "error-free translesion synthesis" RELATED [] +is_a: GO:0006301 ! postreplication repair +is_a: GO:0045021 ! error-free DNA repair + +[Term] +id: GO:0042276 +name: error-prone postreplication DNA repair +namespace: biological_process +def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication, without removing the replication-blocking lesions, and with an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:jl, PMID:11485998] +subset: gosubset_prok +synonym: "error-prone translesion synthesis" RELATED [] +synonym: "mutagenic postreplication DNA repair" EXACT [] +synonym: "mutagenic PRR" EXACT [] +is_a: GO:0006301 ! postreplication repair +is_a: GO:0045020 ! error-prone DNA repair + +[Term] +id: GO:0042277 +name: peptide binding +namespace: molecular_function +def: "Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0042278 +name: purine nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +subset: gosubset_prok +synonym: "purine metabolic process" BROAD [] +synonym: "purine metabolism" BROAD [] +synonym: "purine nucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0042279 +name: nitrite reductase (cytochrome, ammonia-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = NO2(-) (nitrite) + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2] +subset: gosubset_prok +synonym: "ammonia:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.2] +synonym: "cytochrome c nitrite reductase activity" EXACT [] +synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2] +synonym: "multiheme nitrite reductase activity" EXACT [] +synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2] +xref: EC:1.7.2.2 +xref: MetaCyc:1.7.2.2-RXN +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0042280 +name: cell surface antigen activity, host-interacting +namespace: molecular_function +def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb] +comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +is_obsolete: true +consider: GO:0044403 +consider: GO:0046789 + +[Term] +id: GO:0042281 +name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [UniProtKB:Q9VKX7] +synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0042282 +name: hydroxymethylglutaryl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+." [EC:1.1.1.88] +subset: gosubset_prok +synonym: "(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.1.1.88] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" EXACT [EC:1.1.1.88] +synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.88] +synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88] +synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] +synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88] +synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] +synonym: "hydroxymethylglutaryl-CoA reductase (NADH) activity" EXACT [EC:1.1.1.88] +xref: EC:1.1.1.88 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0042283 +name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [UniProtKB:Q9W3V8] +synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0042284 +name: sphingolipid delta-4 desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141] +synonym: "delta-4 sphingolipid desaturase activity" EXACT [] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0042285 +name: xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0042286 +name: glutamate-1-semialdehyde 2,1-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8] +subset: gosubset_prok +synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" EXACT [EC:5.4.3.8] +synonym: "glutamate-1-semialdehyde aminotransferase activity" EXACT [EC:5.4.3.8] +xref: EC:5.4.3.8 +xref: MetaCyc:GSAAMINOTRANS-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0042287 +name: MHC protein binding +namespace: molecular_function +def: "Interacting selectively with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] +comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. +synonym: "major histocompatibility complex binding" EXACT [] +synonym: "major histocompatibility complex ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0042288 +name: MHC class I protein binding +namespace: molecular_function +def: "Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] +comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "major histocompatibility complex class I binding" EXACT [] +synonym: "major histocompatibility complex class I ligand" NARROW [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0042287 ! MHC protein binding + +[Term] +id: GO:0042289 +name: MHC class II protein binding +namespace: molecular_function +def: "Interacting selectively with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] +comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. +synonym: "major histocompatibility complex class II binding" EXACT [] +synonym: "major histocompatibility complex class II ligand" NARROW [] +is_a: GO:0042287 ! MHC protein binding + +[Term] +id: GO:0042290 +name: URM1 hydrolase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0042291 +name: Hub1 hydrolase activity +namespace: molecular_function +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0042292 +name: URM1 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0042293 +name: Hub1 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! small protein activating enzyme activity + +[Term] +id: GO:0042294 +name: URM1 conjugating enzyme activity +namespace: molecular_function +def: "Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules." [GOC:mah, PMID:12826404] +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0042296 +name: ISG15 ligase activity +namespace: molecular_function +def: "Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins." [GOC:mah, PMID:12826404] +synonym: "ISG15 conjugating enzyme activity" EXACT [] +is_a: GO:0019787 ! small conjugating protein ligase activity + +[Term] +id: GO:0042297 +name: vocal learning +namespace: biological_process +def: "A behavioral process whose outcome is a relatively long-lasting adaptive behavioral change whereby an organism modifies innate vocalizations to imitate or create new sounds." [PMID:16418265, PMID:17035521] +is_a: GO:0007612 ! learning +is_a: GO:0031223 ! auditory behavior + +[Term] +id: GO:0042299 +name: lupeol synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization of (S)-2,3-oxidosqualene to lupeol." [PMID:9883589] +synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581] +xref: EC:5.4.99.- +xref: MetaCyc:PWY-112 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0042300 +name: beta-amyrin synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into beta-amyrin." [PMID:9746369] +synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581] +xref: EC:5.4.99.- +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0042301 +name: phosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphate." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0042302 +name: structural constituent of cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0042303 +name: molting cycle +namespace: biological_process +def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0042304 +name: regulation of fatty acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl] +subset: gosubset_prok +synonym: "regulation of fatty acid anabolism" EXACT [] +synonym: "regulation of fatty acid biosynthesis" EXACT [] +synonym: "regulation of fatty acid formation" EXACT [] +synonym: "regulation of fatty acid synthesis" EXACT [] +xref: Reactome:163680 +xref: Reactome:211646 +xref: Reactome:221418 +xref: Reactome:230053 +xref: Reactome:238071 +xref: Reactome:244683 +xref: Reactome:249611 +xref: Reactome:252409 +xref: Reactome:255568 +xref: Reactome:258941 +xref: Reactome:262316 +xref: Reactome:265166 +xref: Reactome:268292 +xref: Reactome:273973 +xref: Reactome:280452 +xref: Reactome:286474 +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0042305 +name: specification of segmental identity, mandibular segment +namespace: biological_process +def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035289 ! posterior head segmentation + +[Term] +id: GO:0042306 +name: regulation of protein import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] +synonym: "regulation of protein import into cell nucleus" EXACT [] +synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of protein-nucleus import" EXACT [] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042307 +name: positive regulation of protein import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] +synonym: "activation of protein import into nucleus" NARROW [] +synonym: "positive regulation of protein import into cell nucleus" EXACT [] +synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of protein-nucleus import" EXACT [] +synonym: "stimulation of protein import into nucleus" NARROW [] +synonym: "up regulation of protein import into nucleus" EXACT [] +synonym: "up-regulation of protein import into nucleus" EXACT [] +synonym: "upregulation of protein import into nucleus" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0051222 ! positive regulation of protein transport +relationship: positively_regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042308 +name: negative regulation of protein import into nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] +synonym: "down regulation of protein import into nucleus" EXACT [] +synonym: "down-regulation of protein import into nucleus" EXACT [] +synonym: "downregulation of protein import into nucleus" EXACT [] +synonym: "inhibition of protein import into nucleus" NARROW [] +synonym: "negative regulation of protein import into cell nucleus" EXACT [] +synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of protein-nucleus import" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0051224 ! negative regulation of protein transport +relationship: negatively_regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042309 +name: homoiothermy +namespace: biological_process +def: "Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023] +synonym: "antifreeze activity" RELATED [] +synonym: "ice nucleation activity" RELATED [] +synonym: "ice nucleation inhibitor activity" RELATED [] +is_a: GO:0001659 ! temperature homeostasis + +[Term] +id: GO:0042310 +name: vasoconstriction +namespace: biological_process +def: "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [ISBN:0192800752] +synonym: "negative regulation of blood vessel size" EXACT [] +is_a: GO:0050880 ! regulation of blood vessel size + +[Term] +id: GO:0042311 +name: vasodilation +namespace: biological_process +def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure." [ISBN:0192800981] +synonym: "positive regulation of blood vessel size" EXACT [] +synonym: "vasodilatation" EXACT [] +is_a: GO:0050880 ! regulation of blood vessel size + +[Term] +id: GO:0042312 +name: regulation of vasodilation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels." [GOC:jl] +synonym: "regulation of vasodilatation" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042311 ! vasodilation + +[Term] +id: GO:0042313 +name: protein kinase C deactivation +namespace: biological_process +def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf] +synonym: "PKC deactivation" EXACT [] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0042314 +name: bacteriochlorophyll binding +namespace: molecular_function +def: "Interacting selectively with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981] +subset: gosubset_prok +is_a: GO:0016168 ! chlorophyll binding + +[Term] +id: GO:0042315 +name: cytosol nonspecific dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "diglycinase activity" EXACT [EC:3.4.13.18] +synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18] +synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18] +synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18] +synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18] +synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18] +synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18] +synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18] +synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18] +synonym: "peptidase A activity" BROAD [EC:3.4.13.18] +synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "prolinase activity" NARROW [EC:3.4.13.18] +synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18] +xref: EC:3.4.13.18 +xref: MetaCyc:3.4.13.18-RXN +is_obsolete: true +replaced_by: GO:0016805 + +[Term] +id: GO:0042316 +name: penicillin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "penicillin metabolism" EXACT [] +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process + +[Term] +id: GO:0042317 +name: penicillin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "penicillin breakdown" EXACT [] +synonym: "penicillin catabolism" EXACT [] +synonym: "penicillin degradation" EXACT [] +is_a: GO:0030655 ! beta-lactam antibiotic catabolic process +is_a: GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0042318 +name: penicillin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "penicillin anabolism" EXACT [] +synonym: "penicillin biosynthesis" EXACT [] +synonym: "penicillin formation" EXACT [] +synonym: "penicillin synthesis" EXACT [] +is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process +is_a: GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0042320 +name: regulation of circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998] +synonym: "regulation of REM sleep" EXACT [] +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep + +[Term] +id: GO:0042321 +name: negative regulation of circadian sleep/wake cycle, sleep +namespace: biological_process +def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981] +synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW [] +synonym: "negative regulation of sleep" EXACT [] +is_a: GO:0042754 ! negative regulation of circadian rhythm +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0042322 +name: negative regulation of circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl] +synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW [] +synonym: "negative regulation of REM sleep" EXACT [] +is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep +is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep +relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep + +[Term] +id: GO:0042323 +name: negative regulation of circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl] +synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW [] +synonym: "negative regulation of non-REM sleep" EXACT [] +is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep +is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep +relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep + +[Term] +id: GO:0042324 +name: hypocretin receptor binding +namespace: molecular_function +def: "Interacting selectively with the hypocretin receptor." [GOC:ceb, PMID:11988773] +synonym: "hypocretin receptor ligand" NARROW [] +synonym: "orexin receptor binding" EXACT [] +synonym: "orexin receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0042325 +name: regulation of phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] +subset: gosubset_prok +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: regulates GO:0016310 ! phosphorylation + +[Term] +id: GO:0042326 +name: negative regulation of phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] +subset: gosubset_prok +synonym: "down regulation of phosphorylation" EXACT [] +synonym: "down-regulation of phosphorylation" EXACT [] +synonym: "downregulation of phosphorylation" EXACT [] +synonym: "inhibition of phosphorylation" NARROW [] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +relationship: negatively_regulates GO:0016310 ! phosphorylation + +[Term] +id: GO:0042327 +name: positive regulation of phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] +subset: gosubset_prok +synonym: "activation of phosphorylation" NARROW [] +synonym: "stimulation of phosphorylation" NARROW [] +synonym: "up regulation of phosphorylation" EXACT [] +synonym: "up-regulation of phosphorylation" EXACT [] +synonym: "upregulation of phosphorylation" EXACT [] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +relationship: positively_regulates GO:0016310 ! phosphorylation + +[Term] +id: GO:0042328 +name: heparan sulfate N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma] +synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED [] +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0042329 +name: structural constituent of collagen and cuticulin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle." [GOC:jl, GOC:mtg_sensu] +synonym: "structural constituent of cuticle (sensu Nematoda)" EXACT [] +is_a: GO:0042302 ! structural constituent of cuticle + +[Term] +id: GO:0042330 +name: taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "directed movement in response to stimulus" EXACT [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0040011 ! locomotion + +[Term] +id: GO:0042331 +name: phototaxis +namespace: biological_process +alt_id: GO:0046953 +def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] +synonym: "phototactic behavior" EXACT [] +synonym: "phototactic behaviour" EXACT [] +synonym: "taxis in response to light" EXACT [] +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0042332 +name: gravitaxis +namespace: biological_process +alt_id: GO:0048062 +def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jic, GOC:jl] +synonym: "geotactic behavior" EXACT [] +synonym: "geotactic behaviour" EXACT [] +synonym: "geotaxis" EXACT [] +synonym: "gravitactic behavior" EXACT [] +synonym: "gravitactic behaviour" EXACT [] +synonym: "taxis in response to gravitational stimulus" EXACT [] +synonym: "taxis in response to gravity" EXACT [] +is_a: GO:0009629 ! response to gravity +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0042333 +name: chemotaxis to oxidizable substrate +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423] +synonym: "taxis in response to oxidizable substrate" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0042334 +name: taxis to electron acceptor +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423] +synonym: "taxis in response to electron acceptor" EXACT [] +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0042335 +name: cuticle development +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825] +synonym: "cuticle anabolism" EXACT [] +synonym: "cuticle biosynthesis" EXACT [] +synonym: "cuticle biosynthetic process" EXACT [] +synonym: "cuticle formation" EXACT [] +synonym: "cuticle synthesis" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0042336 +name: protein-based cuticle development during molting +namespace: biological_process +def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle." [GOC:mtg_sensu] +synonym: "cuticle anabolism during molting (sensu Protostomia and Nematoda)" EXACT [] +synonym: "cuticle biosynthetic process during molting (sensu Protostomia and Nematoda)" EXACT [] +synonym: "cuticle formation during molting (sensu Protostomia and Nematoda)" EXACT [] +synonym: "cuticle synthesis during molting (sensu Protostomia and Nematoda)" EXACT [] +is_a: GO:0007592 ! protein-based cuticle development +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle + +[Term] +id: GO:0042337 +name: chitin-based cuticle development during molting +namespace: biological_process +def: "The synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle." [GOC:jl, GOC:mtg_sensu] +synonym: "cuticle anabolism during molting (sensu Insecta)" EXACT [] +synonym: "cuticle biosynthetic process during molting (sensu Insecta)" EXACT [] +synonym: "cuticle formation during molting (sensu Insecta)" EXACT [] +synonym: "cuticle synthesis during molting (sensu Insecta)" EXACT [] +is_a: GO:0040003 ! chitin-based cuticle development +is_a: GO:0042336 ! protein-based cuticle development during molting +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0042338 +name: collagen and cuticulin-based cuticle development during molting +namespace: biological_process +def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle." [GOC:mtg_sensu] +synonym: "cuticle anabolism during molting (sensu Nematoda)" EXACT [] +synonym: "cuticle biosynthetic process during molting (sensu Nematoda)" EXACT [] +synonym: "cuticle formation during molting (sensu Nematoda)" EXACT [] +synonym: "cuticle synthesis during molting (sensu Nematoda)" EXACT [] +is_a: GO:0040002 ! collagen and cuticulin-based cuticle development +is_a: GO:0042336 ! protein-based cuticle development during molting +relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle + +[Term] +id: GO:0042339 +name: keratan sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] +subset: gosubset_prok +synonym: "keratan sulfate metabolism" EXACT [] +synonym: "keratan sulphate metabolic process" EXACT [] +synonym: "keratan sulphate metabolism" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0042340 +name: keratan sulfate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] +subset: gosubset_prok +synonym: "keratan sulfate breakdown" EXACT [] +synonym: "keratan sulfate catabolism" EXACT [] +synonym: "keratan sulfate degradation" EXACT [] +synonym: "keratan sulphate catabolic process" EXACT [] +synonym: "keratan sulphate catabolism" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0042339 ! keratan sulfate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0042341 +name: cyanogenic glycoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanogenic glycoside metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0042342 +name: cyanogenic glycoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cyanogenic glycoside breakdown" EXACT [] +synonym: "cyanogenic glycoside catabolism" EXACT [] +synonym: "cyanogenic glycoside degradation" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0042341 ! cyanogenic glycoside metabolic process + +[Term] +id: GO:0042343 +name: indole glucosinolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [http://www.onelook.com/] +subset: gosubset_prok +synonym: "indole glucosinolate metabolism" EXACT [] +is_a: GO:0019760 ! glucosinolate metabolic process +is_a: GO:0042434 ! indole derivative metabolic process + +[Term] +id: GO:0042344 +name: indole glucosinolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [http://www.onelook.com] +subset: gosubset_prok +synonym: "indole glucosinolate breakdown" EXACT [] +synonym: "indole glucosinolate catabolism" EXACT [] +synonym: "indole glucosinolate degradation" EXACT [] +is_a: GO:0019762 ! glucosinolate catabolic process +is_a: GO:0042343 ! indole glucosinolate metabolic process +is_a: GO:0042436 ! indole derivative catabolic process + +[Term] +id: GO:0042345 +name: regulation of NF-kappaB import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "regulation of NF-kappaB import into cell nucleus" EXACT [] +synonym: "regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of NF-kappaB-nucleus import" EXACT [] +is_a: GO:0042990 ! regulation of transcription factor import into nucleus +relationship: regulates GO:0042348 ! NF-kappaB import into nucleus + +[Term] +id: GO:0042346 +name: positive regulation of NF-kappaB import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "activation of NF-kappaB import into nucleus" NARROW [] +synonym: "positive regulation of NF-kappaB import into cell nucleus" EXACT [] +synonym: "positive regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of NF-kappaB-nucleus import" EXACT [] +synonym: "stimulation of NF-kappaB import into nucleus" NARROW [] +synonym: "up regulation of NF-kappaB import into nucleus" EXACT [] +synonym: "up-regulation of NF-kappaB import into nucleus" EXACT [] +synonym: "upregulation of NF-kappaB import into nucleus" EXACT [] +is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus +is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus +relationship: positively_regulates GO:0042348 ! NF-kappaB import into nucleus + +[Term] +id: GO:0042347 +name: negative regulation of NF-kappaB import into nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "down regulation of NF-kappaB import into nucleus" EXACT [] +synonym: "down-regulation of NF-kappaB import into nucleus" EXACT [] +synonym: "downregulation of NF-kappaB import into nucleus" EXACT [] +synonym: "inhibition of NF-kappaB import into nucleus" NARROW [] +synonym: "negative regulation of NF-kappaB import into cell nucleus" EXACT [] +synonym: "negative regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of NF-kappaB-nucleus import" EXACT [] +is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus +is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus +relationship: negatively_regulates GO:0042348 ! NF-kappaB import into nucleus + +[Term] +id: GO:0042348 +name: NF-kappaB import into nucleus +namespace: biological_process +def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "NF-kappaB import into cell nucleus" EXACT [] +synonym: "NF-kappaB protein-nucleus import" EXACT [] +synonym: "NF-kappaB transport from cytoplasm to nucleus" EXACT [] +synonym: "NF-kappaB-nucleus import" EXACT [] +is_a: GO:0042991 ! transcription factor import into nucleus + +[Term] +id: GO:0042349 +name: guiding stereospecific synthesis activity +namespace: molecular_function +def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma] +synonym: "dirigent protein" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0042350 +name: GDP-L-fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl] +subset: gosubset_prok +synonym: "GDP-L-fucose anabolism" EXACT [] +synonym: "GDP-L-fucose biosynthesis" EXACT [] +synonym: "GDP-L-fucose formation" EXACT [] +synonym: "GDP-L-fucose synthesis" EXACT [] +is_a: GO:0006005 ! L-fucose biosynthetic process +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046368 ! GDP-L-fucose metabolic process + +[Term] +id: GO:0042351 +name: 'de novo' GDP-L-fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750] +subset: gosubset_prok +synonym: "'de novo' GDP-L-fucose anabolism" EXACT [] +synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT [] +synonym: "'de novo' GDP-L-fucose formation" EXACT [] +synonym: "'de novo' GDP-L-fucose synthesis" EXACT [] +synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT [] +synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT [] +xref: MetaCyc:PWY-66 +is_a: GO:0042350 ! GDP-L-fucose biosynthetic process + +[Term] +id: GO:0042352 +name: GDP-L-fucose salvage +namespace: biological_process +def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma] +subset: gosubset_prok +synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT [] +synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT [] +xref: MetaCyc:PWY-6 +is_a: GO:0043094 ! cellular metabolic compound salvage +is_a: GO:0046368 ! GDP-L-fucose metabolic process + +[Term] +id: GO:0042353 +name: fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl] +subset: gosubset_prok +synonym: "fucose anabolism" EXACT [] +synonym: "fucose biosynthesis" EXACT [] +synonym: "fucose formation" EXACT [] +synonym: "fucose synthesis" EXACT [] +is_a: GO:0006004 ! fucose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0042354 +name: L-fucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-fucose metabolism" EXACT [] +is_a: GO:0006004 ! fucose metabolic process + +[Term] +id: GO:0042355 +name: L-fucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl] +subset: gosubset_prok +synonym: "L-fucose breakdown" EXACT [] +synonym: "L-fucose catabolism" EXACT [] +synonym: "L-fucose degradation" EXACT [] +is_a: GO:0019317 ! fucose catabolic process +is_a: GO:0042354 ! L-fucose metabolic process + +[Term] +id: GO:0042356 +name: GDP-4-dehydro-D-rhamnose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187] +subset: gosubset_prok +synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" EXACT [EC:1.1.1.187] +synonym: "GDP-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] +synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.187] +synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187] +xref: EC:1.1.1.187 +xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0042357 +name: thiamin diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "thiamin diphosphate metabolism" EXACT [] +synonym: "thiamin pyrophosphate metabolic process" EXACT [] +synonym: "thiamin pyrophosphate metabolism" EXACT [] +synonym: "thiamine diphosphate metabolic process" EXACT [] +synonym: "thiamine diphosphate metabolism" EXACT [] +synonym: "thiamine pyrophosphate metabolic process" EXACT [] +synonym: "thiamine pyrophosphate metabolism" EXACT [] +synonym: "TPP metabolic process" EXACT [] +synonym: "TPP metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0042723 ! thiamin and derivative metabolic process + +[Term] +id: GO:0042358 +name: thiamin diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "thiamin diphosphate breakdown" EXACT [] +synonym: "thiamin diphosphate catabolism" EXACT [] +synonym: "thiamin diphosphate degradation" EXACT [] +synonym: "thiamin pyrophosphate catabolic process" EXACT [] +synonym: "thiamin pyrophosphate catabolism" EXACT [] +synonym: "thiamine diphosphate catabolic process" EXACT [] +synonym: "thiamine diphosphate catabolism" EXACT [] +synonym: "thiamine pyrophosphate catabolic process" EXACT [] +synonym: "thiamine pyrophosphate catabolism" EXACT [] +synonym: "TPP catabolic process" EXACT [] +synonym: "TPP catabolism" EXACT [] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0042357 ! thiamin diphosphate metabolic process +is_a: GO:0042725 ! thiamin and derivative catabolic process + +[Term] +id: GO:0042359 +name: vitamin D metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "calciferol metabolic process" EXACT [] +synonym: "calciferol metabolism" EXACT [] +synonym: "cholecalciferol metabolic process" NARROW [] +synonym: "cholecalciferol metabolism" NARROW [] +synonym: "ergocalciferol metabolic process" NARROW [] +synonym: "ergocalciferol metabolism" NARROW [] +synonym: "vitamin D metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process + +[Term] +id: GO:0042360 +name: vitamin E metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "alpha-tocopherol metabolic process" NARROW [] +synonym: "alpha-tocopherol metabolism" NARROW [] +synonym: "tocopherol metabolic process" EXACT [] +synonym: "tocopherol metabolism" EXACT [] +synonym: "vitamin E metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process + +[Term] +id: GO:0042361 +name: menaquinone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "menaquinone breakdown" EXACT [] +synonym: "menaquinone catabolism" EXACT [] +synonym: "menaquinone degradation" EXACT [] +synonym: "menatetrenone catabolic process" EXACT [] +synonym: "menatetrenone catabolism" EXACT [] +synonym: "multiprenylmenaquinone catabolic process" EXACT [] +synonym: "multiprenylmenaquinone catabolism" EXACT [] +synonym: "vitamin K2 catabolic process" EXACT [] +synonym: "vitamin K2 catabolism" EXACT [] +is_a: GO:0009233 ! menaquinone metabolic process +is_a: GO:0042377 ! vitamin K catabolic process + +[Term] +id: GO:0042362 +name: fat-soluble vitamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fat-soluble vitamin anabolism" EXACT [] +synonym: "fat-soluble vitamin biosynthesis" EXACT [] +synonym: "fat-soluble vitamin formation" EXACT [] +synonym: "fat-soluble vitamin synthesis" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0009110 ! vitamin biosynthetic process + +[Term] +id: GO:0042363 +name: fat-soluble vitamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "fat-soluble vitamin breakdown" EXACT [] +synonym: "fat-soluble vitamin catabolism" EXACT [] +synonym: "fat-soluble vitamin degradation" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0009111 ! vitamin catabolic process + +[Term] +id: GO:0042364 +name: water-soluble vitamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl] +subset: gosubset_prok +synonym: "water-soluble vitamin anabolism" EXACT [] +synonym: "water-soluble vitamin biosynthesis" EXACT [] +synonym: "water-soluble vitamin formation" EXACT [] +synonym: "water-soluble vitamin synthesis" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0009110 ! vitamin biosynthetic process + +[Term] +id: GO:0042365 +name: water-soluble vitamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "water-soluble vitamin breakdown" EXACT [] +synonym: "water-soluble vitamin catabolism" EXACT [] +synonym: "water-soluble vitamin degradation" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0009111 ! vitamin catabolic process + +[Term] +id: GO:0042366 +name: cobalamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] +subset: gosubset_prok +synonym: "cobalamin breakdown" EXACT [] +synonym: "cobalamin catabolism" EXACT [] +synonym: "cobalamin degradation" EXACT [] +synonym: "vitamin B12 catabolic process" EXACT [] +synonym: "vitamin B12 catabolism" EXACT [] +is_a: GO:0006787 ! porphyrin catabolic process +is_a: GO:0009235 ! cobalamin metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process + +[Term] +id: GO:0042367 +name: biotin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "biotin breakdown" EXACT [] +synonym: "biotin catabolism" EXACT [] +synonym: "biotin degradation" EXACT [] +synonym: "vitamin B7 catabolic process" EXACT [] +synonym: "vitamin B7 catabolism" EXACT [] +synonym: "vitamin H catabolic process" EXACT [] +synonym: "vitamin H catabolism" EXACT [] +is_a: GO:0006768 ! biotin metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0042368 +name: vitamin D biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "calciferol biosynthesis" EXACT [] +synonym: "calciferol biosynthetic process" EXACT [] +synonym: "cholecalciferol biosynthesis" NARROW [] +synonym: "cholecalciferol biosynthetic process" NARROW [] +synonym: "ergocalciferol biosynthesis" NARROW [] +synonym: "ergocalciferol biosynthetic process" NARROW [] +synonym: "vitamin D anabolism" EXACT [] +synonym: "vitamin D biosynthesis" EXACT [] +synonym: "vitamin D formation" EXACT [] +synonym: "vitamin D synthesis" EXACT [] +is_a: GO:0042359 ! vitamin D metabolic process +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process + +[Term] +id: GO:0042369 +name: vitamin D catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the human bloodstream. Vitamin D is also known as calciferol and five different forms are known, including ergocalciferol and cholecalciferol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "calciferol catabolic process" EXACT [] +synonym: "calciferol catabolism" EXACT [] +synonym: "cholecalciferol biosynthesis" NARROW [] +synonym: "cholecalciferol biosynthetic process" NARROW [] +synonym: "ergocalciferol biosynthesis" NARROW [] +synonym: "ergocalciferol biosynthetic process" NARROW [] +synonym: "vitamin D breakdown" EXACT [] +synonym: "vitamin D catabolism" EXACT [] +synonym: "vitamin D degradation" EXACT [] +is_a: GO:0042359 ! vitamin D metabolic process +is_a: GO:0042363 ! fat-soluble vitamin catabolic process + +[Term] +id: GO:0042370 +name: thiamin diphosphate dephosphorylation +namespace: biological_process +def: "The removal of one or more phosphate groups from thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "thiamine diphosphate dephosphorylation" EXACT [] +synonym: "TPP dephosphorylation" EXACT [] +is_a: GO:0042357 ! thiamin diphosphate metabolic process + +[Term] +id: GO:0042371 +name: vitamin K biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "naphthoquinone metabolic process" BROAD [] +synonym: "naphthoquinone metabolism" BROAD [] +synonym: "vitamin K anabolism" EXACT [] +synonym: "vitamin K biosynthesis" EXACT [] +synonym: "vitamin K formation" EXACT [] +synonym: "vitamin K synthesis" EXACT [] +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process +is_a: GO:0042373 ! vitamin K metabolic process +is_a: GO:0045426 ! quinone cofactor biosynthetic process + +[Term] +id: GO:0042372 +name: phylloquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "phylloquinone anabolism" EXACT [] +synonym: "phylloquinone biosynthesis" EXACT [] +synonym: "phylloquinone formation" EXACT [] +synonym: "phylloquinone synthesis" EXACT [] +synonym: "phytomenadione biosynthesis" EXACT [] +synonym: "phytomenadione biosynthetic process" EXACT [] +synonym: "phytonadione biosynthesis" EXACT [] +synonym: "phytonadione biosynthetic process" EXACT [] +synonym: "phytylmenaquinone biosynthesis" EXACT [] +synonym: "phytylmenaquinone biosynthetic process" EXACT [] +synonym: "vitamin K1 biosynthesis" EXACT [] +synonym: "vitamin K1 biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5027 +is_a: GO:0042371 ! vitamin K biosynthetic process +is_a: GO:0042374 ! phylloquinone metabolic process + +[Term] +id: GO:0042373 +name: vitamin K metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "naphthoquinone metabolic process" BROAD [] +synonym: "naphthoquinone metabolism" BROAD [] +synonym: "vitamin K metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0042375 ! quinone cofactor metabolic process + +[Term] +id: GO:0042374 +name: phylloquinone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "phylloquinone metabolism" EXACT [] +synonym: "phytomenadione metabolic process" EXACT [] +synonym: "phytomenadione metabolism" EXACT [] +synonym: "phytonadione metabolic process" EXACT [] +synonym: "phytonadione metabolism" EXACT [] +synonym: "phytylmenaquinone metabolic process" EXACT [] +synonym: "phytylmenaquinone metabolism" EXACT [] +synonym: "vitamin K1 metabolic process" EXACT [] +synonym: "vitamin K1 metabolism" EXACT [] +is_a: GO:0042373 ! vitamin K metabolic process + +[Term] +id: GO:0042375 +name: quinone cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving quinone cofactors." [GOC:go_curators] +subset: gosubset_prok +synonym: "quinone cofactor metabolism" EXACT [] +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0042376 +name: phylloquinone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "phylloquinone breakdown" EXACT [] +synonym: "phylloquinone catabolism" EXACT [] +synonym: "phylloquinone degradation" EXACT [] +synonym: "phytomenadione catabolic process" EXACT [] +synonym: "phytomenadione catabolism" EXACT [] +synonym: "phytonadione catabolic process" EXACT [] +synonym: "phytonadione catabolism" EXACT [] +synonym: "phytylmenaquinone catabolic process" EXACT [] +synonym: "phytylmenaquinone catabolism" EXACT [] +synonym: "vitamin K1 catabolic process" EXACT [] +synonym: "vitamin K1 catabolism" EXACT [] +is_a: GO:0042374 ! phylloquinone metabolic process +is_a: GO:0042377 ! vitamin K catabolic process + +[Term] +id: GO:0042377 +name: vitamin K catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +subset: gosubset_prok +synonym: "naphthoquinone catabolic process" EXACT [] +synonym: "naphthoquinone catabolism" EXACT [] +synonym: "vitamin K breakdown" EXACT [] +synonym: "vitamin K catabolism" EXACT [] +synonym: "vitamin K degradation" EXACT [] +is_a: GO:0042363 ! fat-soluble vitamin catabolic process +is_a: GO:0042373 ! vitamin K metabolic process +is_a: GO:0042378 ! quinone cofactor catabolic process + +[Term] +id: GO:0042378 +name: quinone cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of quinone cofactors." [GOC:go_curators] +subset: gosubset_prok +synonym: "quinone cofactor breakdown" EXACT [] +synonym: "quinone cofactor catabolism" EXACT [] +synonym: "quinone cofactor degradation" EXACT [] +is_a: GO:0009109 ! coenzyme catabolic process +is_a: GO:0042375 ! quinone cofactor metabolic process + +[Term] +id: GO:0042379 +name: chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with any chemokine receptor." [GOC:ai] +synonym: "chemokine receptor ligand" NARROW [] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0042380 +name: hydroxymethylbutenyl pyrophosphate reductase activity +namespace: molecular_function +def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js] +comment: Note that the enzyme performing this function has only recently been characterized, and not completely (see PMID:11818558). The common and systematic names have been suggested by TIGR, who have recently compiled an HMM model for this gene (TIGR00216). The enzyme appears to catalyze the final step in the non-mevalonate terpene biosynthesis pathway. Its two products, isopentenyl pyrophosphate and dimethylallyl pyrophosphate, are apparently generated from a common intermediate formed by the enzyme. The mechanism and identity of the reductant have not yet been determined. +subset: gosubset_prok +synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0042381 +name: hemolymph coagulation +namespace: biological_process +def: "Any process by which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10561606, PMID:11915949] +synonym: "hemolymph clotting" EXACT [] +is_a: GO:0006959 ! humoral immune response +is_a: GO:0007599 ! hemostasis +is_a: GO:0045087 ! innate immune response +is_a: GO:0050817 ! coagulation +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0042382 +name: paraspeckles +namespace: cellular_component +def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0042383 +name: sarcolemma +namespace: cellular_component +def: "The outer membrane of a muscle fiber, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005886 ! plasma membrane + +[Term] +id: GO:0042384 +name: cilium biogenesis +namespace: biological_process +def: "The assembly of a cilium, a specialized eukaryotic locomotor organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ciliogenesis" EXACT [] +is_a: GO:0030031 ! cell projection biogenesis + +[Term] +id: GO:0042385 +name: myosin III complex +namespace: cellular_component +def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0042386 +name: hemocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/, PMID:9550723] +synonym: "arthropod blood cell differentiation" EXACT [] +synonym: "hemocyte differentiation (sensu Arthropoda)" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0042387 +name: plasmatocyte differentiation +namespace: biological_process +def: "The process by which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791] +is_a: GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0042388 +name: gibberellic acid mediated signaling, G-alpha-dependent +namespace: biological_process +def: "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] +synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT [] +is_a: GO:0009740 ! gibberellic acid mediated signaling + +[Term] +id: GO:0042389 +name: omega-3 fatty acid desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020] +xref: EC:1.14.99.- +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0042390 +name: gibberellic acid mediated signaling, G-alpha-independent +namespace: biological_process +def: "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] +synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT [] +is_a: GO:0009740 ! gibberellic acid mediated signaling + +[Term] +id: GO:0042391 +name: regulation of membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006873 ! cellular ion homeostasis + +[Term] +id: GO:0042392 +name: sphingosine-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102] +synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT [] +synonym: "SPP phosphatase activity" EXACT [] +synonym: "SPPase activity" EXACT [] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0042393 +name: histone binding +namespace: molecular_function +def: "Interacting selectively with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] +synonym: "histone-specific chaperone activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042394 +name: ecdysis, protein-based cuticle +namespace: biological_process +def: "The shedding of the old protein-based cuticular fragments during the molting cycle." [GOC:jl, GOC:mtg_sensu] +synonym: "ecdysis (sensu Protostomia and Nematoda)" EXACT [] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle + +[Term] +id: GO:0042395 +name: ecdysis, collagen and cuticulin-based cuticle +namespace: biological_process +def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle." [GOC:jl, GOC:mtg_sensu] +synonym: "ecdysis (sensu Nematoda)" EXACT [] +is_a: GO:0042394 ! ecdysis, protein-based cuticle +relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle + +[Term] +id: GO:0042396 +name: phosphagen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphagen anabolism" EXACT [] +synonym: "phosphagen biosynthesis" EXACT [] +synonym: "phosphagen formation" EXACT [] +synonym: "phosphagen synthesis" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0042397 +name: phosphagen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphagen breakdown" EXACT [] +synonym: "phosphagen catabolism" EXACT [] +synonym: "phosphagen degradation" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0042398 +name: amino acid derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] +subset: gosubset_prok +synonym: "amino acid derivative anabolism" EXACT [] +synonym: "amino acid derivative biosynthesis" EXACT [] +synonym: "amino acid derivative formation" EXACT [] +synonym: "amino acid derivative synthesis" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042399 +name: ectoine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] +subset: gosubset_prok +synonym: "ectoine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0042400 +name: ectoine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] +subset: gosubset_prok +synonym: "ectoine breakdown" EXACT [] +synonym: "ectoine catabolism" EXACT [] +synonym: "ectoine degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042399 ! ectoine metabolic process + +[Term] +id: GO:0042401 +name: biogenic amine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] +subset: gosubset_prok +synonym: "biogenic amine anabolism" EXACT [] +synonym: "biogenic amine biosynthesis" EXACT [] +synonym: "biogenic amine formation" EXACT [] +synonym: "biogenic amine synthesis" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0009309 ! amine biosynthetic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0042402 +name: biogenic amine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "biogenic amine breakdown" EXACT [] +synonym: "biogenic amine catabolism" EXACT [] +synonym: "biogenic amine degradation" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0009310 ! amine catabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0042403 +name: thyroid hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "thyroid hormone metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0042404 +name: thyroid hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "thyroid hormone breakdown" EXACT [] +synonym: "thyroid hormone catabolism" EXACT [] +synonym: "thyroid hormone degradation" EXACT [] +is_a: GO:0042402 ! biogenic amine catabolic process +is_a: GO:0042403 ! thyroid hormone metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0042405 +name: nuclear inclusion body +namespace: cellular_component +def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl] +is_a: GO:0016234 ! inclusion body +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0042406 +name: extrinsic to endoplasmic reticulum membrane +namespace: cellular_component +def: "Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "extrinsic to ER membrane" EXACT [] +is_a: GO:0031312 ! extrinsic to organelle membrane +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0042407 +name: cristae formation +namespace: biological_process +def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0007007 ! inner mitochondrial membrane organization + +[Term] +id: GO:0042408 +name: myrcene/(E)-beta-ocimene synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382] +comment: This term was made obsolete because it represents two activities. +synonym: "myrcene/ocimene synthase activity" EXACT [] +xref: EC:4.6.-.- +is_obsolete: true + +[Term] +id: GO:0042409 +name: caffeoyl-CoA O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104] +subset: gosubset_prok +synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT [] +synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] +synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104] +xref: EC:2.1.1.104 +xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0042410 +name: 6-carboxyhexanoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA." [EC:6.2.1.14] +subset: gosubset_prok +synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.14] +synonym: "6-carboxyhexanoyl-CoA synthetase activity" EXACT [EC:6.2.1.14] +synonym: "pimeloyl-CoA synthetase activity" EXACT [EC:6.2.1.14] +synonym: "pimelyl-CoA synthetase activity" EXACT [EC:6.2.1.14] +xref: EC:6.2.1.14 +xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0042411 +name: beta-carotene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of both beta rings of beta-carotene to form zeaxanthine." [GOC:cr] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0042412 +name: taurine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] +subset: gosubset_prok +synonym: "taurine anabolism" EXACT [] +synonym: "taurine biosynthesis" EXACT [] +synonym: "taurine formation" EXACT [] +synonym: "taurine synthesis" EXACT [] +is_a: GO:0019530 ! taurine metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0042413 +name: carnitine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carnitine breakdown" EXACT [] +synonym: "carnitine catabolism" EXACT [] +synonym: "carnitine degradation" EXACT [] +synonym: "vitamin Bt catabolic process" EXACT [] +synonym: "vitamin Bt catabolism" EXACT [] +is_a: GO:0009437 ! carnitine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0042414 +name: epinephrine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "adrenaline metabolic process" EXACT [] +synonym: "adrenaline metabolism" EXACT [] +synonym: "epinephrine metabolism" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042415 +name: norepinephrine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "levarterenol metabolic process" EXACT [] +synonym: "levarterenol metabolism" EXACT [] +synonym: "noradrenaline metabolic process" EXACT [] +synonym: "noradrenaline metabolism" EXACT [] +synonym: "norepinephrine metabolism" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042416 +name: dopamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "dopamine anabolism" EXACT [] +synonym: "dopamine biosynthesis" EXACT [] +synonym: "dopamine formation" EXACT [] +synonym: "dopamine synthesis" EXACT [] +is_a: GO:0042417 ! dopamine metabolic process +is_a: GO:0042423 ! catecholamine biosynthetic process + +[Term] +id: GO:0042417 +name: dopamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "dopamine metabolism" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042418 +name: epinephrine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "adrenaline biosynthesis" EXACT [] +synonym: "adrenaline biosynthetic process" EXACT [] +synonym: "epinephrine anabolism" EXACT [] +synonym: "epinephrine biosynthesis" EXACT [] +synonym: "epinephrine formation" EXACT [] +synonym: "epinephrine synthesis" EXACT [] +is_a: GO:0042414 ! epinephrine metabolic process +is_a: GO:0042423 ! catecholamine biosynthetic process + +[Term] +id: GO:0042419 +name: epinephrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "adrenaline catabolic process" EXACT [] +synonym: "adrenaline catabolism" EXACT [] +synonym: "epinephrine breakdown" EXACT [] +synonym: "epinephrine catabolism" EXACT [] +synonym: "epinephrine degradation" EXACT [] +is_a: GO:0042414 ! epinephrine metabolic process +is_a: GO:0042424 ! catecholamine catabolic process + +[Term] +id: GO:0042420 +name: dopamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "dopamine breakdown" EXACT [] +synonym: "dopamine catabolism" EXACT [] +synonym: "dopamine degradation" EXACT [] +is_a: GO:0042417 ! dopamine metabolic process +is_a: GO:0042424 ! catecholamine catabolic process + +[Term] +id: GO:0042421 +name: norepinephrine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "levarterenol biosynthesis" EXACT [] +synonym: "levarterenol biosynthetic process" EXACT [] +synonym: "noradrenaline biosynthesis" EXACT [] +synonym: "noradrenaline biosynthetic process" EXACT [] +synonym: "norepinephrine anabolism" EXACT [] +synonym: "norepinephrine biosynthesis" EXACT [] +synonym: "norepinephrine formation" EXACT [] +synonym: "norepinephrine synthesis" EXACT [] +is_a: GO:0042415 ! norepinephrine metabolic process +is_a: GO:0042423 ! catecholamine biosynthetic process + +[Term] +id: GO:0042422 +name: norepinephrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "levarterenol catabolic process" EXACT [] +synonym: "levarterenol catabolism" EXACT [] +synonym: "noradrenaline catabolic process" EXACT [] +synonym: "noradrenaline catabolism" EXACT [] +synonym: "norepinephrine breakdown" EXACT [] +synonym: "norepinephrine catabolism" EXACT [] +synonym: "norepinephrine degradation" EXACT [] +is_a: GO:0042415 ! norepinephrine metabolic process +is_a: GO:0042424 ! catecholamine catabolic process + +[Term] +id: GO:0042423 +name: catecholamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "catecholamine anabolism" EXACT [] +synonym: "catecholamine biosynthesis" EXACT [] +synonym: "catecholamine formation" EXACT [] +synonym: "catecholamine synthesis" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0042424 +name: catecholamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "catecholamine breakdown" EXACT [] +synonym: "catecholamine catabolism" EXACT [] +synonym: "catecholamine degradation" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0042425 +name: choline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "choline anabolism" EXACT [] +synonym: "choline biosynthesis" EXACT [] +synonym: "choline formation" EXACT [] +synonym: "choline synthesis" EXACT [] +xref: MetaCyc:PWY-4762 +is_a: GO:0019695 ! choline metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0042426 +name: choline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] +subset: gosubset_prok +synonym: "choline breakdown" EXACT [] +synonym: "choline catabolism" EXACT [] +synonym: "choline degradation" EXACT [] +is_a: GO:0019695 ! choline metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0042427 +name: serotonin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "serotonin anabolism" EXACT [] +synonym: "serotonin biosynthesis" EXACT [] +synonym: "serotonin formation" EXACT [] +synonym: "serotonin synthesis" EXACT [] +is_a: GO:0042428 ! serotonin metabolic process +is_a: GO:0046219 ! indolalkylamine biosynthetic process + +[Term] +id: GO:0042428 +name: serotonin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "serotonin metabolism" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process + +[Term] +id: GO:0042429 +name: serotonin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "serotonin breakdown" EXACT [] +synonym: "serotonin catabolism" EXACT [] +synonym: "serotonin degradation" EXACT [] +is_a: GO:0042428 ! serotonin metabolic process +is_a: GO:0046218 ! indolalkylamine catabolic process + +[Term] +id: GO:0042430 +name: indole and derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan) formed in degradation of tryptophan, and compounds derived from it." [GOC:jl] +subset: gosubset_prok +synonym: "indole and derivative metabolism" EXACT [] +synonym: "ketole metabolic process" EXACT [] +synonym: "ketole metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0042431 +name: indole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "indole metabolism" EXACT [] +is_a: GO:0042430 ! indole and derivative metabolic process + +[Term] +id: GO:0042432 +name: indole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "indole anabolism" EXACT [] +synonym: "indole biosynthesis" EXACT [] +synonym: "indole formation" EXACT [] +synonym: "indole synthesis" EXACT [] +is_a: GO:0042431 ! indole metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042433 +name: indole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "indole breakdown" EXACT [] +synonym: "indole catabolism" EXACT [] +synonym: "indole degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042431 ! indole metabolic process + +[Term] +id: GO:0042434 +name: indole derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving compounds derived from indole (2,3-benzopyrrole)." [GOC:jl] +subset: gosubset_prok +synonym: "indole derivative metabolism" EXACT [] +is_a: GO:0042430 ! indole and derivative metabolic process + +[Term] +id: GO:0042435 +name: indole derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds derived from indole (2,3-benzopyrrole)." [GOC:jl] +subset: gosubset_prok +synonym: "indole derivative anabolism" EXACT [] +synonym: "indole derivative biosynthesis" EXACT [] +synonym: "indole derivative formation" EXACT [] +synonym: "indole derivative synthesis" EXACT [] +is_a: GO:0042434 ! indole derivative metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042436 +name: indole derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from indole (2,3-benzopyrrole)." [GOC:jl] +subset: gosubset_prok +synonym: "indole derivative breakdown" EXACT [] +synonym: "indole derivative catabolism" EXACT [] +synonym: "indole derivative degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042434 ! indole derivative metabolic process + +[Term] +id: GO:0042437 +name: indoleacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl] +subset: gosubset_prok +synonym: "IAA catabolic process" EXACT [] +synonym: "indole acetic acid catabolic process" EXACT [] +synonym: "indole acetic acid catabolism" EXACT [] +synonym: "indoleacetic acid breakdown" EXACT [] +synonym: "indoleacetic acid catabolism" EXACT [] +synonym: "indoleacetic acid degradation" EXACT [] +is_a: GO:0009683 ! indoleacetic acid metabolic process +is_a: GO:0009852 ! auxin catabolic process +is_a: GO:0042436 ! indole derivative catabolic process + +[Term] +id: GO:0042438 +name: melanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "melanin anabolism" EXACT [] +synonym: "melanin biosynthesis" EXACT [] +synonym: "melanin formation" EXACT [] +synonym: "melanin synthesis" EXACT [] +is_a: GO:0006582 ! melanin metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0042439 +name: ethanolamine and derivative metabolic process +namespace: biological_process +subset: gosubset_prok +synonym: "ethanolamine and derivative metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process + +[Term] +id: GO:0042440 +name: pigment metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "pigment metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0042441 +name: eye pigment metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] +synonym: "eye pigment metabolism" EXACT [] +is_a: GO:0042440 ! pigment metabolic process +relationship: part_of GO:0048069 ! eye pigmentation + +[Term] +id: GO:0042442 +name: melatonin catabolic process +namespace: biological_process +alt_id: GO:0042449 +def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl] +subset: gosubset_prok +synonym: "melatonin breakdown" EXACT [] +synonym: "melatonin catabolism" EXACT [] +synonym: "melatonin degradation" EXACT [] +is_a: GO:0030186 ! melatonin metabolic process +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0046218 ! indolalkylamine catabolic process + +[Term] +id: GO:0042443 +name: phenylethylamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] +synonym: "phenylethylamine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0042133 ! neurotransmitter metabolic process + +[Term] +id: GO:0042444 +name: phenylethylamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] +synonym: "phenylethylamine anabolism" EXACT [] +synonym: "phenylethylamine biosynthesis" EXACT [] +synonym: "phenylethylamine formation" EXACT [] +synonym: "phenylethylamine synthesis" EXACT [] +is_a: GO:0042136 ! neurotransmitter biosynthetic process +is_a: GO:0042401 ! biogenic amine biosynthetic process +is_a: GO:0042443 ! phenylethylamine metabolic process + +[Term] +id: GO:0042445 +name: hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +subset: gosubset_prok +synonym: "hormone metabolism" EXACT [] +xref: Reactome:207167 +xref: Reactome:216741 +xref: Reactome:225626 +xref: Reactome:234265 +xref: Reactome:242016 +xref: Reactome:247390 +xref: Reactome:76521 +is_a: GO:0008152 ! metabolic process +is_a: GO:0010817 ! regulation of hormone levels + +[Term] +id: GO:0042446 +name: hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "hormone anabolism" EXACT [] +synonym: "hormone biosynthesis" EXACT [] +synonym: "hormone formation" EXACT [] +synonym: "hormone synthesis" EXACT [] +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042447 +name: hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "hormone breakdown" EXACT [] +synonym: "hormone catabolism" EXACT [] +synonym: "hormone degradation" EXACT [] +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042448 +name: progesterone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] +synonym: "progesterone metabolism" EXACT [] +is_a: GO:0008207 ! C21-steroid hormone metabolic process + +[Term] +id: GO:0042450 +name: arginine biosynthetic process via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl] +subset: gosubset_prok +synonym: "arginine anabolism via ornithine" EXACT [] +synonym: "arginine formation via ornithine" EXACT [] +synonym: "arginine synthesis via ornithine" EXACT [] +is_a: GO:0006526 ! arginine biosynthetic process +is_a: GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0042451 +name: purine nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] +subset: gosubset_prok +synonym: "purine nucleoside anabolism" EXACT [] +synonym: "purine nucleoside biosynthesis" EXACT [] +synonym: "purine nucleoside formation" EXACT [] +synonym: "purine nucleoside synthesis" EXACT [] +is_a: GO:0009163 ! nucleoside biosynthetic process +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0042452 +name: deoxyguanosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "deoxyguanosine anabolism" EXACT [] +synonym: "deoxyguanosine biosynthesis" EXACT [] +synonym: "deoxyguanosine formation" EXACT [] +synonym: "deoxyguanosine synthesis" EXACT [] +is_a: GO:0042453 ! deoxyguanosine metabolic process +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0042453 +name: deoxyguanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "deoxyguanosine metabolism" EXACT [] +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0042454 +name: ribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "ribonucleoside breakdown" EXACT [] +synonym: "ribonucleoside catabolism" EXACT [] +synonym: "ribonucleoside degradation" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process +is_a: GO:0009164 ! nucleoside catabolic process + +[Term] +id: GO:0042455 +name: ribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "ribonucleoside anabolism" EXACT [] +synonym: "ribonucleoside biosynthesis" EXACT [] +synonym: "ribonucleoside formation" EXACT [] +synonym: "ribonucleoside synthesis" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process +is_a: GO:0009163 ! nucleoside biosynthetic process + +[Term] +id: GO:0042457 +name: ethylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845] +subset: gosubset_prok +synonym: "ethene catabolic process" EXACT [] +synonym: "ethene catabolism" EXACT [] +synonym: "ethylene breakdown" EXACT [] +synonym: "ethylene catabolism" EXACT [] +synonym: "ethylene degradation" EXACT [] +is_a: GO:0009692 ! ethylene metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042458 +name: nopaline catabolic process to proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators] +subset: gosubset_prok +synonym: "nopaline breakdown to proline" EXACT [] +synonym: "nopaline degradation to proline" EXACT [] +xref: MetaCyc:NOPALINEDEG-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0019468 ! nopaline catabolic process + +[Term] +id: GO:0042459 +name: octopine catabolic process to proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators] +subset: gosubset_prok +synonym: "octopine breakdown to proline" EXACT [] +synonym: "octopine degradation to proline" EXACT [] +xref: MetaCyc:OCTOPINEDEG-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0019469 ! octopine catabolic process + +[Term] +id: GO:0042461 +name: photoreceptor cell development +namespace: biological_process +alt_id: GO:0046531 +def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] +synonym: "photoreceptor morphogenesis" EXACT [] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0042462 +name: eye photoreceptor cell development +namespace: biological_process +def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] +is_a: GO:0042461 ! photoreceptor cell development +relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation + +[Term] +id: GO:0042463 +name: ocellus photoreceptor cell development +namespace: biological_process +alt_id: GO:0001749 +def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766] +synonym: "non-eye photoreceptor development (sensu Endopterygota)" EXACT [] +is_a: GO:0042461 ! photoreceptor cell development +relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation + +[Term] +id: GO:0042464 +name: dosage compensation, by hypoactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes." [GOC:jl, PMID:11102361] +synonym: "dosage compensation (sensu Nematoda)" EXACT [] +is_a: GO:0007549 ! dosage compensation + +[Term] +id: GO:0042465 +name: kinesis +namespace: biological_process +def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023] +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0042466 +name: chemokinesis +namespace: biological_process +def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0042465 ! kinesis + +[Term] +id: GO:0042467 +name: orthokinesis +namespace: biological_process +def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0042465 ! kinesis + +[Term] +id: GO:0042468 +name: klinokinesis +namespace: biological_process +def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0042465 ! kinesis + +[Term] +id: GO:0042469 +name: versicolorin reductase activity +namespace: molecular_function +def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [UniProtKB:P50161] +xref: EC:1.1.-.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0042470 +name: melanosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0042471 +name: ear morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the ear are generated and organized. Morphogenesis pertains to the creation of form. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] +synonym: "hearing organ morphogenesis" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0043583 ! ear development + +[Term] +id: GO:0042472 +name: inner ear morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the inner ear are generated and organized. Morphogenesis pertains to the creation of form. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0042471 ! ear morphogenesis +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0042473 +name: outer ear morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the outer ear are generated and organized. Morphogenesis pertains to the creation of form. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0042471 ! ear morphogenesis + +[Term] +id: GO:0042474 +name: middle ear morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of middle ear are generated and organized. Morphogenesis pertains to the creation of form. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0042471 ! ear morphogenesis + +[Term] +id: GO:0042475 +name: odontogenesis of dentine-containing tooth +namespace: biological_process +def: "The process whose specific outcome is the progression of a dentine-containing tooth over time, from its formation to the mature structure. A dentine-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and are composed mainly of dentine, a dense calcified substance, covered by a layer of enamel." [GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794] +synonym: "odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "odontogenesis of dentine-containing teeth" EXACT [] +synonym: "odontogeny (sensu Vertebrata)" EXACT [] +synonym: "odontosis (sensu Vertebrata)" EXACT [] +synonym: "tooth development (sensu Vertebrata)" EXACT [] +is_a: GO:0042476 ! odontogenesis + +[Term] +id: GO:0042476 +name: odontogenesis +namespace: biological_process +alt_id: GO:0042477 +def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] +synonym: "odontogenesis (sensu Protostomia)" NARROW [] +synonym: "odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "odontogeny" EXACT [] +synonym: "odontosis" EXACT [] +synonym: "tooth development" EXACT [] +synonym: "tooth development (sensu Invertebrata)" NARROW [] +is_a: GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0042478 +name: regulation of eye photoreceptor cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] +synonym: "regulation of eye photoreceptor development" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0042479 +name: positive regulation of eye photoreceptor cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] +synonym: "activation of eye photoreceptor cell development" NARROW [] +synonym: "positive regulation of eye photoreceptor development" EXACT [] +synonym: "stimulation of eye photoreceptor cell development" NARROW [] +synonym: "up regulation of eye photoreceptor cell development" EXACT [] +synonym: "up-regulation of eye photoreceptor cell development" EXACT [] +synonym: "upregulation of eye photoreceptor cell development" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0042478 ! regulation of eye photoreceptor cell development +relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0042480 +name: negative regulation of eye photoreceptor cell development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] +synonym: "down regulation of eye photoreceptor cell development" EXACT [] +synonym: "down-regulation of eye photoreceptor cell development" EXACT [] +synonym: "downregulation of eye photoreceptor cell development" EXACT [] +synonym: "inhibition of eye photoreceptor cell development" NARROW [] +synonym: "negative regulation of eye photoreceptor development" EXACT [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0042478 ! regulation of eye photoreceptor cell development +relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0042481 +name: regulation of odontogenesis +namespace: biological_process +alt_id: GO:0042484 +def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] +synonym: "regulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "regulation of tooth development" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042476 ! odontogenesis + +[Term] +id: GO:0042482 +name: positive regulation of odontogenesis +namespace: biological_process +alt_id: GO:0042485 +def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] +synonym: "activation of odontogenesis" NARROW [] +synonym: "activation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "positive regulation of odontogenesis (sensu Protostomia)" EXACT [] +synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "positive regulation of tooth development" EXACT [] +synonym: "stimulation of odontogenesis" NARROW [] +synonym: "stimulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "up regulation of odontogenesis" EXACT [] +synonym: "up regulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "up-regulation of odontogenesis" EXACT [] +synonym: "up-regulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "upregulation of odontogenesis" EXACT [] +synonym: "upregulation of odontogenesis (sensu Protostomia)" NARROW [] +is_a: GO:0042481 ! regulation of odontogenesis +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0042476 ! odontogenesis + +[Term] +id: GO:0042483 +name: negative regulation of odontogenesis +namespace: biological_process +alt_id: GO:0042486 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] +synonym: "down regulation of odontogenesis" EXACT [] +synonym: "down regulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "down-regulation of odontogenesis" EXACT [] +synonym: "down-regulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "downregulation of odontogenesis" EXACT [] +synonym: "downregulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "inhibition of odontogenesis" NARROW [] +synonym: "inhibition of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "negative regulation of odontogenesis (sensu Protostomia)" NARROW [] +synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "negative regulation of tooth development" EXACT [] +is_a: GO:0042481 ! regulation of odontogenesis +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0042476 ! odontogenesis + +[Term] +id: GO:0042487 +name: regulation of odontogenesis of dentine-containing tooth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/, PMID:15355794] +synonym: "regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT [] +is_a: GO:0042481 ! regulation of odontogenesis +relationship: regulates GO:0042475 ! odontogenesis of dentine-containing tooth + +[Term] +id: GO:0042488 +name: positive regulation of odontogenesis of dentine-containing tooth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [DDB_REF:2530 "DictyBase paper repository", GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:15355794] +synonym: "activation of odontogenesis (sensu Vertebrata)" NARROW [] +synonym: "positive regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT [] +synonym: "stimulation of odontogenesis (sensu Vertebrata)" NARROW [] +synonym: "up regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "up-regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "upregulation of odontogenesis (sensu Vertebrata)" EXACT [] +is_a: GO:0042482 ! positive regulation of odontogenesis +is_a: GO:0042487 ! regulation of odontogenesis of dentine-containing tooth +relationship: positively_regulates GO:0042475 ! odontogenesis of dentine-containing tooth + +[Term] +id: GO:0042489 +name: negative regulation of odontogenesis of dentine-containing tooth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/, PMID:15355794] +synonym: "down regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "down-regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "downregulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "inhibition of odontogenesis (sensu Vertebrata)" NARROW [] +synonym: "negative regulation of odontogenesis (sensu Vertebrata)" EXACT [] +synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT [] +is_a: GO:0042483 ! negative regulation of odontogenesis +is_a: GO:0042487 ! regulation of odontogenesis of dentine-containing tooth +relationship: negatively_regulates GO:0042475 ! odontogenesis of dentine-containing tooth + +[Term] +id: GO:0042490 +name: mechanoreceptor differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0042491 +name: auditory receptor cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an auditory hair cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] +comment: Note that this term refers to the mechanosensory hair cells of the inner ear. +synonym: "auditory hair cell differentiation" EXACT [] +is_a: GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0042492 +name: gamma-delta T cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell." [GOC:jl] +synonym: "gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "gamma-delta T-cell differentiation" EXACT [] +synonym: "gamma-delta T-lymphocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation +is_a: GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0042493 +name: response to drug +namespace: biological_process +alt_id: GO:0017035 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl] +subset: goslim_candida +subset: gosubset_prok +synonym: "drug resistance" RELATED [] +synonym: "drug susceptibility/resistance" RELATED [] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0042494 +name: detection of bacterial lipoprotein +namespace: biological_process +def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222] +synonym: "detection of BLP" RELATED [] +synonym: "detection of Lpp" RELATED [] +synonym: "perception of bacterial lipoprotein" RELATED [] +synonym: "perception of BLP" RELATED [] +synonym: "perception of Lpp" RELATED [] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0032493 ! response to bacterial lipoprotein +relationship: part_of GO:0016045 ! detection of bacterium + +[Term] +id: GO:0042495 +name: detection of triacylated bacterial lipoprotein +namespace: biological_process +def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are triacylated lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222] +synonym: "perception of triacylated bacterial lipoprotein" RELATED [] +is_a: GO:0042494 ! detection of bacterial lipoprotein + +[Term] +id: GO:0042496 +name: detection of diacylated bacterial lipoprotein +namespace: biological_process +def: "The series of events in which a diacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are diacylated lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222] +synonym: "perception of diacylated bacterial lipoprotein" RELATED [] +is_a: GO:0042494 ! detection of bacterial lipoprotein + +[Term] +id: GO:0042497 +name: triacylated lipoprotein binding +namespace: molecular_function +def: "Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a three acyl groups." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008034 ! lipoprotein binding + +[Term] +id: GO:0042498 +name: diacylated lipoprotein binding +namespace: molecular_function +def: "Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a two acyl groups." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008034 ! lipoprotein binding + +[Term] +id: GO:0042499 +name: signal peptide peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416] +comment: This term was made obsolete because it represents a gene product. +synonym: "SPP" EXACT [] +xref: EC:3.4.23.- +is_obsolete: true +replaced_by: GO:0042500 + +[Term] +id: GO:0042500 +name: aspartic endopeptidase activity, intramembrane cleaving +namespace: molecular_function +def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases. +xref: EC:3.4.23.- +is_a: GO:0004190 ! aspartic-type endopeptidase activity + +[Term] +id: GO:0042501 +name: serine phosphorylation of STAT protein +namespace: biological_process +def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] +is_a: GO:0018105 ! peptidyl-serine phosphorylation +relationship: part_of GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0042502 +name: tyrosine phosphorylation of Stat2 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042503 +name: tyrosine phosphorylation of Stat3 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042504 +name: tyrosine phosphorylation of Stat4 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042505 +name: tyrosine phosphorylation of Stat6 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042506 +name: tyrosine phosphorylation of Stat5 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042507 +name: tyrosine phosphorylation of Stat7 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042508 +name: tyrosine phosphorylation of Stat1 protein +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] +is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042509 +name: regulation of tyrosine phosphorylation of STAT protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] +is_a: GO:0046425 ! regulation of JAK-STAT cascade +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042510 +name: regulation of tyrosine phosphorylation of Stat1 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein + +[Term] +id: GO:0042511 +name: positive regulation of tyrosine phosphorylation of Stat1 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] +synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" EXACT [] +is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein + +[Term] +id: GO:0042512 +name: negative regulation of tyrosine phosphorylation of Stat1 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594] +synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW [] +is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein + +[Term] +id: GO:0042513 +name: regulation of tyrosine phosphorylation of Stat2 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein + +[Term] +id: GO:0042514 +name: negative regulation of tyrosine phosphorylation of Stat2 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] +synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW [] +is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein + +[Term] +id: GO:0042515 +name: positive regulation of tyrosine phosphorylation of Stat2 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594] +synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" EXACT [] +is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein + +[Term] +id: GO:0042516 +name: regulation of tyrosine phosphorylation of Stat3 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein + +[Term] +id: GO:0042517 +name: positive regulation of tyrosine phosphorylation of Stat3 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" EXACT [] +is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein + +[Term] +id: GO:0042518 +name: negative regulation of tyrosine phosphorylation of Stat3 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW [] +is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein + +[Term] +id: GO:0042519 +name: regulation of tyrosine phosphorylation of Stat4 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein + +[Term] +id: GO:0042520 +name: positive regulation of tyrosine phosphorylation of Stat4 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" EXACT [] +is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein + +[Term] +id: GO:0042521 +name: negative regulation of tyrosine phosphorylation of Stat4 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW [] +is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein + +[Term] +id: GO:0042522 +name: regulation of tyrosine phosphorylation of Stat5 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein + +[Term] +id: GO:0042523 +name: positive regulation of tyrosine phosphorylation of Stat5 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" EXACT [] +is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein + +[Term] +id: GO:0042524 +name: negative regulation of tyrosine phosphorylation of Stat5 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW [] +is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein + +[Term] +id: GO:0042525 +name: regulation of tyrosine phosphorylation of Stat6 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein + +[Term] +id: GO:0042526 +name: positive regulation of tyrosine phosphorylation of Stat6 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" EXACT [] +is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein + +[Term] +id: GO:0042527 +name: negative regulation of tyrosine phosphorylation of Stat6 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW [] +is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein + +[Term] +id: GO:0042528 +name: regulation of tyrosine phosphorylation of Stat7 protein +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +relationship: regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein + +[Term] +id: GO:0042529 +name: positive regulation of tyrosine phosphorylation of Stat7 protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" EXACT [] +is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein +is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein +relationship: positively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein + +[Term] +id: GO:0042530 +name: negative regulation of tyrosine phosphorylation of Stat7 protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW [] +is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein +is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein + +[Term] +id: GO:0042531 +name: positive regulation of tyrosine phosphorylation of STAT protein +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT [] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +is_a: GO:0046427 ! positive regulation of JAK-STAT cascade +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042532 +name: negative regulation of tyrosine phosphorylation of STAT protein +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW [] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +is_a: GO:0046426 ! negative regulation of JAK-STAT cascade +is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation +relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042533 +name: tumor necrosis factor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "TNF alpha biosynthesis" EXACT [] +synonym: "TNF alpha biosynthetic process" EXACT [] +synonym: "TNF biosynthesis" EXACT [] +synonym: "TNF biosynthetic process" EXACT [] +synonym: "TNF-alpha biosynthesis" EXACT [] +synonym: "TNF-alpha biosynthetic process" EXACT [] +synonym: "Tumor Necrosis Factor alpha biosynthesis" EXACT [] +synonym: "Tumor Necrosis Factor alpha biosynthetic process" EXACT [] +synonym: "tumor necrosis factor anabolism" EXACT [] +synonym: "tumor necrosis factor biosynthesis" EXACT [] +synonym: "tumor necrosis factor formation" EXACT [] +synonym: "tumor necrosis factor synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0042534 +name: regulation of tumor necrosis factor biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "regulation of TNF alpha biosynthesis" EXACT [] +synonym: "regulation of TNF alpha biosynthetic process" EXACT [] +synonym: "regulation of TNF biosynthesis" EXACT [] +synonym: "regulation of TNF biosynthetic process" EXACT [] +synonym: "regulation of TNF-alpha biosynthesis" EXACT [] +synonym: "regulation of TNF-alpha biosynthetic process" EXACT [] +synonym: "regulation of tumor necrosis factor anabolism" EXACT [] +synonym: "regulation of tumor necrosis factor biosynthesis" EXACT [] +synonym: "regulation of tumor necrosis factor formation" EXACT [] +synonym: "regulation of tumor necrosis factor synthesis" EXACT [] +synonym: "regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] +synonym: "regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] +is_a: GO:0032680 ! regulation of tumor necrosis factor production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042533 ! tumor necrosis factor biosynthetic process + +[Term] +id: GO:0042535 +name: positive regulation of tumor necrosis factor biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "activation of tumor necrosis factor biosynthetic process" NARROW [] +synonym: "positive regulation of TNF alpha biosynthesis" EXACT [] +synonym: "positive regulation of TNF alpha biosynthetic process" EXACT [] +synonym: "positive regulation of TNF biosynthesis" EXACT [] +synonym: "positive regulation of TNF biosynthetic process" EXACT [] +synonym: "positive regulation of TNF-alpha biosynthesis" EXACT [] +synonym: "positive regulation of TNF-alpha biosynthetic process" EXACT [] +synonym: "positive regulation of tumor necrosis factor anabolism" EXACT [] +synonym: "positive regulation of tumor necrosis factor biosynthesis" EXACT [] +synonym: "positive regulation of tumor necrosis factor formation" EXACT [] +synonym: "positive regulation of tumor necrosis factor synthesis" EXACT [] +synonym: "positive regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] +synonym: "positive regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] +synonym: "stimulation of tumor necrosis factor biosynthetic process" NARROW [] +synonym: "up regulation of tumor necrosis factor biosynthetic process" EXACT [] +synonym: "up-regulation of tumor necrosis factor biosynthetic process" EXACT [] +synonym: "upregulation of tumor necrosis factor biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process +relationship: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process + +[Term] +id: GO:0042536 +name: negative regulation of tumor necrosis factor biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "down regulation of tumor necrosis factor biosynthetic process" EXACT [] +synonym: "down-regulation of tumor necrosis factor biosynthetic process" EXACT [] +synonym: "downregulation of tumor necrosis factor biosynthetic process" EXACT [] +synonym: "inhibition of tumor necrosis factor biosynthetic process" NARROW [] +synonym: "negative regulation of TNF alpha biosynthesis" EXACT [] +synonym: "negative regulation of TNF alpha biosynthetic process" EXACT [] +synonym: "negative regulation of TNF biosynthesis" EXACT [] +synonym: "negative regulation of TNF biosynthetic process" EXACT [] +synonym: "negative regulation of TNF-alpha biosynthesis" EXACT [] +synonym: "negative regulation of TNF-alpha biosynthetic process" EXACT [] +synonym: "negative regulation of tumor necrosis factor anabolism" EXACT [] +synonym: "negative regulation of tumor necrosis factor biosynthesis" EXACT [] +synonym: "negative regulation of tumor necrosis factor formation" EXACT [] +synonym: "negative regulation of tumor necrosis factor synthesis" EXACT [] +synonym: "negative regulation of tumor necrosis factor-alpha biosynthesis" EXACT [] +synonym: "negative regulation of tumor necrosis factor-alpha biosynthetic process" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process +relationship: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process + +[Term] +id: GO:0042537 +name: benzene and derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "benzene and derivative metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0042538 +name: hyperosmotic salinity response +namespace: biological_process +def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] +synonym: "response to hyperosmotic salt stress" EXACT [] +synonym: "salt tolerance" RELATED [] +is_a: GO:0006972 ! hyperosmotic response +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0042539 +name: hypotonic salinity response +namespace: biological_process +def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] +synonym: "response to hypotonic salt stress" EXACT [] +is_a: GO:0006971 ! hypotonic response +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0042540 +name: hemoglobin catabolic process +namespace: biological_process +alt_id: GO:0020029 +def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [GOC:jl, GOC:mb, http://cancerweb.ncl.ac.uk/] +comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process. +synonym: "haemoglobin catabolic process" EXACT [] +synonym: "haemoglobin catabolism" EXACT [] +synonym: "haemoglobin hydrolysis" NARROW [] +synonym: "hemoglobin breakdown" EXACT [] +synonym: "hemoglobin catabolism" EXACT [] +synonym: "hemoglobin degradation" EXACT [] +synonym: "hemoglobin hydrolysis" NARROW [] +is_a: GO:0020027 ! hemoglobin metabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0042541 +name: hemoglobin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "haemoglobin biosynthesis" EXACT [] +synonym: "haemoglobin biosynthetic process" EXACT [] +synonym: "hemoglobin anabolism" EXACT [] +synonym: "hemoglobin biosynthesis" EXACT [] +synonym: "hemoglobin formation" EXACT [] +synonym: "hemoglobin synthesis" EXACT [] +is_a: GO:0020027 ! hemoglobin metabolic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process + +[Term] +id: GO:0042542 +name: response to hydrogen peroxide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] +subset: gosubset_prok +is_a: GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:0042543 +name: protein amino acid N-linked glycosylation via arginine +namespace: biological_process +def: "The posttranslational glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327] +subset: gosubset_prok +xref: RESID:AA0327 +is_a: GO:0006487 ! protein amino acid N-linked glycosylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0042544 +name: melibiose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "melibiose anabolism" EXACT [] +synonym: "melibiose biosynthesis" EXACT [] +synonym: "melibiose formation" EXACT [] +synonym: "melibiose synthesis" EXACT [] +is_a: GO:0005994 ! melibiose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0042545 +name: cell wall modification +namespace: biological_process +def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl] +subset: gosubset_prok +is_a: GO:0007047 ! cell wall organization + +[Term] +id: GO:0042546 +name: cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cell wall anabolism" EXACT [] +synonym: "cell wall assembly" EXACT [] +synonym: "cell wall biosynthesis" EXACT [] +synonym: "cell wall biosynthetic process" EXACT [] +synonym: "cell wall formation" EXACT [] +synonym: "cell wall synthesis" EXACT [] +is_a: GO:0007047 ! cell wall organization + +[Term] +id: GO:0042547 +name: cell wall modification during multidimensional cell growth +namespace: biological_process +def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls." [GOC:jl] +subset: gosubset_prok +synonym: "cell wall modification during cell expansion" EXACT [] +is_a: GO:0042545 ! cell wall modification +relationship: part_of GO:0009825 ! multidimensional cell growth + +[Term] +id: GO:0042548 +name: regulation of photosynthesis, light reaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] +is_a: GO:0010109 ! regulation of photosynthesis +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0042549 +name: photosystem II stabilization +namespace: biological_process +def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] +is_a: GO:0042548 ! regulation of photosynthesis, light reaction + +[Term] +id: GO:0042550 +name: photosystem I stabilization +namespace: biological_process +def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] +is_a: GO:0042548 ! regulation of photosynthesis, light reaction + +[Term] +id: GO:0042551 +name: neuron maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0042552 +name: myelination +namespace: biological_process +def: "The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0042554 +name: superoxide release +namespace: biological_process +def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750] +subset: gosubset_prok +is_a: GO:0006801 ! superoxide metabolic process + +[Term] +id: GO:0042555 +name: MCM complex +namespace: cellular_component +def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] +synonym: "mini-chromosome maintenance complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043596 ! nuclear replication fork + +[Term] +id: GO:0042556 +name: eukaryotic elongation factor-2 kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] +synonym: "eEF-2 kinase regulator" EXACT [] +xref: EC:2.7.1.- +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0042557 +name: eukaryotic elongation factor-2 kinase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] +synonym: "eEF-2 kinase activator" EXACT [] +xref: EC:2.7.1.- +is_a: GO:0030295 ! protein kinase activator activity +is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity + +[Term] +id: GO:0042558 +name: pteridine and derivative metabolic process +namespace: biological_process +alt_id: GO:0019721 +def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pteridine and derivative metabolism" EXACT [] +synonym: "pterin metabolic process" EXACT [] +synonym: "pterin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process + +[Term] +id: GO:0042559 +name: pteridine and derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pteridine and derivative anabolism" EXACT [] +synonym: "pteridine and derivative biosynthesis" EXACT [] +synonym: "pteridine and derivative formation" EXACT [] +synonym: "pteridine and derivative synthesis" EXACT [] +synonym: "pterin biosynthesis" EXACT [] +synonym: "pterin biosynthetic process" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0042560 +name: pteridine and derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pteridine and derivative breakdown" EXACT [] +synonym: "pteridine and derivative catabolism" EXACT [] +synonym: "pteridine and derivative degradation" EXACT [] +synonym: "pterin catabolic process" EXACT [] +synonym: "pterin catabolism" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0042561 +name: alpha-amyrin synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into alpha-amyrin." [GOC:jl, PMID:10848960] +xref: MetaCyc:PWY-5377 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0042562 +name: hormone binding +namespace: molecular_function +def: "Interacting selectively with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0042563 +name: importin alpha-subunit nuclear export complex +namespace: cellular_component +def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] +is_a: GO:0031074 ! nucleocytoplasmic shuttling complex + +[Term] +id: GO:0042564 +name: NLS-dependent protein nuclear import complex +namespace: cellular_component +def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] +is_a: GO:0031074 ! nucleocytoplasmic shuttling complex + +[Term] +id: GO:0042565 +name: RNA nuclear export complex +namespace: cellular_component +def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123] +is_a: GO:0031074 ! nucleocytoplasmic shuttling complex + +[Term] +id: GO:0042566 +name: hydrogenosome +namespace: cellular_component +def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0042567 +name: insulin-like growth factor ternary complex +namespace: cellular_component +def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] +synonym: "IGF ternary complex" EXACT [] +is_a: GO:0016942 ! insulin-like growth factor binding protein complex + +[Term] +id: GO:0042568 +name: insulin-like growth factor binary complex +namespace: cellular_component +def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] +synonym: "IGF binary complex" EXACT [] +is_a: GO:0016942 ! insulin-like growth factor binding protein complex + +[Term] +id: GO:0042571 +name: immunoglobulin complex, circulating +namespace: cellular_component +def: "A multi-subunit complex that functions as an antibody and circulates in the blood, lymph, mucosal areas, and other fluids of the body. In its basic form, circulating immunoglobulin is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0019814 ! immunoglobulin complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0042572 +name: retinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "retinol metabolism" EXACT [] +synonym: "vitamin A1 alcohol metabolic process" EXACT [] +synonym: "vitamin A1 alcohol metabolism" EXACT [] +synonym: "vitamin A1 metabolic process" EXACT [] +synonym: "vitamin A1 metabolism" EXACT [] +is_a: GO:0001523 ! retinoid metabolic process +is_a: GO:0006776 ! vitamin A metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0042573 +name: retinoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "retinoic acid metabolism" EXACT [] +synonym: "vitamin A1 acid metabolic process" EXACT [] +synonym: "vitamin A1 acid metabolism" EXACT [] +is_a: GO:0006776 ! vitamin A metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0042574 +name: retinal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "retinal metabolism" EXACT [] +synonym: "retinaldehyde metabolic process" EXACT [] +synonym: "retinaldehyde metabolism" EXACT [] +is_a: GO:0001523 ! retinoid metabolic process +is_a: GO:0006776 ! vitamin A metabolic process +is_a: GO:0043288 ! apocarotenoid metabolic process + +[Term] +id: GO:0042575 +name: DNA polymerase complex +namespace: cellular_component +def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:12045093] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0042576 +name: aspartyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +xref: EC:3.4.11.21 +xref: MetaCyc:3.4.11.21-RXN +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0042577 +name: lipid phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0042578 +name: phosphoric ester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] +subset: gosubset_prok +xref: EC:3.1.-.- +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0042579 +name: microbody +namespace: cellular_component +def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0042580 +name: mannosome +namespace: cellular_component +def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0042581 +name: specific granule +namespace: cellular_component +def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:7334549] +synonym: "secondary granule" EXACT [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042582 +name: azurophil granule +namespace: cellular_component +def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "primary granule" EXACT [] +is_a: GO:0005766 ! primary lysosome +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042583 +name: chromaffin granule +namespace: cellular_component +def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042584 +name: chromaffin granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042583 ! chromaffin granule + +[Term] +id: GO:0042585 +name: germinal vesicle +namespace: cellular_component +def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/] +synonym: "primary oocyte nucleus" EXACT [] +is_a: GO:0001674 ! female germ cell nucleus + +[Term] +id: GO:0042586 +name: peptide deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl] +subset: gosubset_prok +synonym: "formyl-L-methionyl peptide amidohydrolase activity" EXACT [EC:3.5.1.88] +synonym: "PDF activity" EXACT [EC:3.5.1.88] +synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88] +xref: EC:3.5.1.88 +xref: MetaCyc:3.5.1.88-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0042587 +name: glycogen granule +namespace: cellular_component +def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957] +synonym: "glycogen particle" EXACT [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0042588 +name: zymogen granule +namespace: cellular_component +def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042589 +name: zymogen granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042588 ! zymogen granule + +[Term] +id: GO:0042590 +name: antigen processing and presentation of exogenous peptide antigen via MHC class I +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT [] +synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT [] +synonym: "cross presentation" BROAD [] +synonym: "cross priming" BROAD [] +synonym: "cross-presentation" BROAD [] +synonym: "cross-priming" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I +is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen + +[Term] +id: GO:0042592 +name: homeostatic process +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal equilibrium." [GOC:jl, ISBN:0395825172] +subset: gosubset_prok +synonym: "homeostasis" RELATED [] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0042593 +name: glucose homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of glucose within an organism or cell." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0033500 ! carbohydrate homeostasis + +[Term] +id: GO:0042594 +name: response to starvation +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006950 ! response to stress +is_a: GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0042595 +name: behavioral response to starvation +namespace: biological_process +def: "A change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] +synonym: "behavioural response to starvation" EXACT [] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0042596 +name: fear response +namespace: biological_process +alt_id: GO:0001663 +def: "The response of an organism to a perceived external threat." [GOC:go_curators] +synonym: "physiological fear response" EXACT [] +is_a: GO:0033555 ! multicellular organismal response to stress + +[Term] +id: GO:0042597 +name: periplasmic space +namespace: cellular_component +alt_id: GO:0005620 +def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi)." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +synonym: "periplasm" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0042598 +name: vesicular fraction +namespace: cellular_component +def: "Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl] +comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. +subset: gosubset_prok +is_a: GO:0005624 ! membrane fraction + +[Term] +id: GO:0042599 +name: lamellar body +namespace: cellular_component +def: "A membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:jl, PMID:12243725] +synonym: "keratinosome" EXACT [] +synonym: "lamellar granule" EXACT [] +synonym: "membrane-coating granule" EXACT [] +synonym: "Odland body" EXACT [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042600 +name: chorion +namespace: cellular_component +def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO. +subset: goslim_pir +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0042601 +name: endospore-forming forespore +namespace: cellular_component +def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029] +subset: gosubset_prok +synonym: "forespore (sensu Bacteria)" EXACT [] +is_a: GO:0042763 ! intracellular immature spore + +[Term] +id: GO:0042602 +name: flavin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + H+." [EC:1.5.1.30] +subset: gosubset_prok +synonym: "FMN reductase (NADPH) activity" EXACT [EC:1.5.1.30] +synonym: "NADPH dehydrogenase (flavin) activity" EXACT [EC:1.5.1.30] +synonym: "NADPH-dependent FMN reductase activity" EXACT [EC:1.5.1.30] +synonym: "NADPH-flavin oxidoreductase activity" EXACT [] +synonym: "NADPH-flavin reductase activity" EXACT [EC:1.5.1.30] +synonym: "NADPH-FMN reductase activity" EXACT [EC:1.5.1.30] +synonym: "NADPH-specific FMN reductase activity" EXACT [EC:1.5.1.30] +synonym: "NADPH2 dehydrogenase (flavin)" EXACT [EC:1.5.1.30] +synonym: "NADPH2:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] +synonym: "NADPH:flavin oxidoreductase activity" EXACT [EC:1.5.1.30] +synonym: "NADPH:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30] +synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.30] +synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.30] +synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30] +synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30] +xref: EC:1.5.1.30 +xref: MetaCyc:NADPH-DEHYDROGENASE-(FLAVIN)-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0042603 +name: capsule +namespace: cellular_component +alt_id: GO:0030113 +alt_id: GO:0042604 +def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and can not be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg] +subset: gosubset_prok +synonym: "capsule (sensu Bacteria)" EXACT [] +synonym: "capsule (sensu Fungi)" EXACT [] +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0042605 +name: peptide antigen binding +namespace: molecular_function +alt_id: GO:0042606 +alt_id: GO:0042607 +def: "Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jl] +comment: Note that this term can be used to describe binding to the peptide expressed by an MHC molecule. +synonym: "endogenous peptide antigen binding" NARROW [] +synonym: "exogenous peptide antigen binding" NARROW [] +is_a: GO:0003823 ! antigen binding +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0042608 +name: T cell receptor binding +namespace: molecular_function +def: "Interacting selectively with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "T lymphocyte receptor binding" EXACT [] +synonym: "T-cell receptor binding" EXACT [] +synonym: "T-lymphocyte receptor binding" EXACT [] +synonym: "TCR binding" EXACT [] +is_a: GO:0005102 ! receptor binding +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0042609 +name: CD4 receptor binding +namespace: molecular_function +def: "Interacting selectively with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MeSH:D015704] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0042610 +name: CD8 receptor binding +namespace: molecular_function +def: "Interacting selectively with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MeSH:D016827] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0042611 +name: MHC protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149 "Fundamental Immunology", PMID:15928678, PMID:16153240] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0042612 +name: MHC class I protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149 "Fundamental Immunology"] +comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'. +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: GO:0042613 +name: MHC class II protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: GO:0042614 +name: CD70 receptor binding +namespace: molecular_function +def: "Interacting selectively with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859] +synonym: "CD27 receptor activity" RELATED [] +synonym: "CD27L binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0042615 +name: CD154 receptor binding +namespace: molecular_function +def: "Interacting selectively with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859] +synonym: "CD40 receptor activity" RELATED [] +synonym: "CD40L binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0042616 +name: paclitaxel metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "paclitaxel metabolism" EXACT [] +synonym: "taxol metabolic process" NARROW [] +synonym: "taxol metabolism" NARROW [] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0042617 +name: paclitaxel biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "paclitaxel anabolism" EXACT [] +synonym: "paclitaxel biosynthesis" EXACT [] +synonym: "paclitaxel formation" EXACT [] +synonym: "paclitaxel synthesis" EXACT [] +synonym: "taxol biosynthesis" NARROW [] +synonym: "taxol biosynthetic process" NARROW [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042616 ! paclitaxel metabolic process + +[Term] +id: GO:0042618 +name: poly-hydroxybutyrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html] +subset: gosubset_prok +synonym: "PHB metabolic process" EXACT [] +synonym: "PHB metabolism" EXACT [] +synonym: "poly-hydroxybutyrate metabolism" EXACT [] +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:0042619 +name: poly-hydroxybutyrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html] +subset: gosubset_prok +synonym: "PHB biosynthesis" EXACT [] +synonym: "PHB biosynthetic process" EXACT [] +synonym: "poly-hydroxybutyrate anabolism" EXACT [] +synonym: "poly-hydroxybutyrate biosynthesis" EXACT [] +synonym: "poly-hydroxybutyrate formation" EXACT [] +synonym: "poly-hydroxybutyrate synthesis" EXACT [] +is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process +is_a: GO:0046358 ! butyrate biosynthetic process + +[Term] +id: GO:0042620 +name: poly(3-hydroxyalkanoate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] +subset: goslim_pir +subset: gosubset_prok +synonym: "PHA metabolic process" BROAD [] +synonym: "PHA metabolism" BROAD [] +synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT [] +is_a: GO:0043283 ! biopolymer metabolic process + +[Term] +id: GO:0042621 +name: poly(3-hydroxyalkanoate) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] +subset: gosubset_prok +synonym: "PHA biosynthesis" BROAD [] +synonym: "PHA biosynthetic process" BROAD [] +synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT [] +synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT [] +synonym: "poly(3-hydroxyalkanoate) formation" EXACT [] +synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT [] +is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process +is_a: GO:0043284 ! biopolymer biosynthetic process + +[Term] +id: GO:0042622 +name: photoreceptor outer segment membrane +namespace: cellular_component +def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl] +is_a: GO:0016020 ! membrane +is_a: GO:0044441 ! cilium part +relationship: part_of GO:0001750 ! photoreceptor outer segment + +[Term] +id: GO:0042623 +name: ATPase activity, coupled +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9] +synonym: "chaperonin" RELATED [EC:3.6.4.9] +synonym: "chaperonin ATPase activity" RELATED [] +synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] +synonym: "nucleoplasmin ATPase activity" RELATED [] +synonym: "peroxisome-assembly ATPase activity" RELATED [] +is_a: GO:0016887 ! ATPase activity + +[Term] +id: GO:0042624 +name: ATPase activity, uncoupled +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; not directly coupled to any other reaction." [EC:3.6.1.3] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "adenylpyrophosphatase activity" RELATED [EC:3.6.1.3] +xref: EC:3.6.1.3 +xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN +is_a: GO:0016887 ! ATPase activity + +[Term] +id: GO:0042625 +name: ATPase activity, coupled to transmembrane movement of ions +namespace: molecular_function +def: "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:def, GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0042626 +name: ATPase activity, coupled to transmembrane movement of substances +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ABC transporter" NARROW [] +synonym: "ABC-type efflux permease activity" NARROW [] +synonym: "ABC-type efflux porter activity" NARROW [] +synonym: "ABC-type uptake permease activity" NARROW [] +synonym: "ATP binding cassette transporter" NARROW [] +synonym: "ATP-binding cassette (ABC) transporter activity" NARROW [] +synonym: "ATP-binding cassette transporter" NARROW [] +synonym: "mating pheromone exporter" NARROW [] +is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity +is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances +is_a: GO:0043492 ! ATPase activity, coupled to movement of substances + +[Term] +id: GO:0042627 +name: chylomicron +namespace: cellular_component +def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, http://cancerweb.ncl.ac.uk/] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0042628 +name: mating plug formation +namespace: biological_process +def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, http://www.wildcru.org/glossary/glossary.htm, http://www.wormatlas.org/glossaries/cglossary.htm, PMID:11267893] +synonym: "copulatory plug biosynthesis" EXACT [] +synonym: "copulatory plug deposition" EXACT [] +synonym: "copulatory plug formation" EXACT [] +synonym: "mating plug deposition" EXACT [] +is_a: GO:0045297 ! post-mating behavior +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0042629 +name: mast cell granule +namespace: cellular_component +def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0042630 +name: behavioral response to water deprivation +namespace: biological_process +def: "A change in the behavior of an organism as a result of deprivation of water." [GOC:jl] +synonym: "behavioral response to drought" EXACT [] +synonym: "behavioral response to thirst" EXACT [] +synonym: "behavioural response to water deprivation" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009414 ! response to water deprivation + +[Term] +id: GO:0042631 +name: cellular response to water deprivation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators] +synonym: "cellular response to drought" EXACT [] +is_a: GO:0009414 ! response to water deprivation +is_a: GO:0031668 ! cellular response to extracellular stimulus +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0042632 +name: cholesterol homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of cholesterol within an organism or cell." [GOC:go_curators] +is_a: GO:0055092 ! sterol homeostasis + +[Term] +id: GO:0042633 +name: hair cycle +namespace: biological_process +def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, http://cancerweb.ncl.ac.uk/, PMID:12230507] +is_a: GO:0042303 ! molting cycle + +[Term] +id: GO:0042634 +name: regulation of hair cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042633 ! hair cycle + +[Term] +id: GO:0042635 +name: positive regulation of hair cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] +synonym: "activation of hair cycle" NARROW [] +synonym: "stimulation of hair cycle" NARROW [] +synonym: "up regulation of hair cycle" EXACT [] +synonym: "up-regulation of hair cycle" EXACT [] +synonym: "upregulation of hair cycle" EXACT [] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0042633 ! hair cycle + +[Term] +id: GO:0042636 +name: negative regulation of hair cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] +synonym: "down regulation of hair cycle" EXACT [] +synonym: "down-regulation of hair cycle" EXACT [] +synonym: "downregulation of hair cycle" EXACT [] +synonym: "inhibition of hair cycle" NARROW [] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0042633 ! hair cycle + +[Term] +id: GO:0042637 +name: catagen +namespace: biological_process +def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193] +synonym: "hair regression" NARROW [] +is_a: GO:0022405 ! hair cycle process +relationship: part_of GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0042638 +name: exogen +namespace: biological_process +def: "The shedding phase of the hair cycle." [PMID:12230507] +synonym: "hair shedding" NARROW [] +is_a: GO:0022405 ! hair cycle process +relationship: part_of GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0042639 +name: telogen +namespace: biological_process +def: "The resting phase of hair cycle." [PMID:12230507] +synonym: "hair resting phase" NARROW [] +is_a: GO:0022405 ! hair cycle process + +[Term] +id: GO:0042640 +name: anagen +namespace: biological_process +def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507] +synonym: "hair growth" NARROW [] +is_a: GO:0022405 ! hair cycle process +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0042641 +name: actomyosin +namespace: cellular_component +def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +synonym: "actomyosin complex" EXACT [] +synonym: "actomyosin structure" EXACT [] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0042642 +name: actomyosin, myosin complex part +namespace: cellular_component +def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +is_a: GO:0016459 ! myosin complex +relationship: part_of GO:0042641 ! actomyosin + +[Term] +id: GO:0042643 +name: actomyosin, actin part +namespace: cellular_component +def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +is_a: GO:0005884 ! actin filament +relationship: part_of GO:0042641 ! actomyosin + +[Term] +id: GO:0042644 +name: chloroplast nucleoid +namespace: cellular_component +def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] +is_a: GO:0042646 ! plastid nucleoid +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0042645 +name: mitochondrial nucleoid +namespace: cellular_component +def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] +is_a: GO:0009295 ! nucleoid +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0042646 +name: plastid nucleoid +namespace: cellular_component +def: "The region of a plastid to which the DNA is confined." [GOC:jl] +is_a: GO:0009295 ! nucleoid +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009532 ! plastid stroma + +[Term] +id: GO:0042647 +name: proplastid nucleoid +namespace: cellular_component +def: "The region of a proplastid to which the DNA is confined." [GOC:jl] +is_a: GO:0042646 ! plastid nucleoid +relationship: part_of GO:0009571 ! proplastid stroma + +[Term] +id: GO:0042648 +name: chloroplast chromosome +namespace: cellular_component +def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] +is_a: GO:0009508 ! plastid chromosome +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0042644 ! chloroplast nucleoid + +[Term] +id: GO:0042649 +name: prothylakoid +namespace: cellular_component +def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175] +is_a: GO:0031976 ! plastid thylakoid +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0042650 +name: prothylakoid membrane +namespace: cellular_component +def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175] +is_a: GO:0055035 ! plastid thylakoid membrane +relationship: part_of GO:0042649 ! prothylakoid + +[Term] +id: GO:0042651 +name: thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of any thylakoid." [GOC:jl] +subset: gosubset_prok +is_a: GO:0031090 ! organelle membrane +is_a: GO:0034357 ! photosynthetic membrane +is_a: GO:0044436 ! thylakoid part + +[Term] +id: GO:0042652 +name: mitochondrial respiratory chain complex I, peripheral segment +namespace: cellular_component +def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jic, GOC:mtg_sensu, ISBN:0716749556] +synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment (sensu Eukaryota)" EXACT [] +synonym: "NADH-Q oxidoreductase complex, peripheral segment (sensu Eukaryota)" EXACT [] +synonym: "respiratory chain complex I, peripheral segment (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I + +[Term] +id: GO:0042653 +name: mitochondrial respiratory chain complex I, membrane segment +namespace: cellular_component +def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jic, GOC:mtg_sensu, ISBN:0716749556] +synonym: "NADH-Q oxidoreductase complex, membrane segment (sensu Eukaryota)" EXACT [] +synonym: "respiratory chain complex I, membrane segment (sensu Eukaryota)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I + +[Term] +id: GO:0042654 +name: ecdysis-triggering hormone receptor activity +namespace: molecular_function +def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma] +synonym: "ecdysis-triggering hormone binding" NARROW [] +synonym: "ETH receptor" EXACT [] +is_a: GO:0004930 ! G-protein coupled receptor activity +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0042655 +name: activation of JNKKK activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase." [GOC:bf] +synonym: "activation of JUN kinase kinase kinase activity" EXACT [] +synonym: "positive regulation of JUNKKK activity" BROAD [] +is_a: GO:0000185 ! activation of MAPKKK activity +relationship: part_of GO:0007254 ! JNK cascade + +[Term] +id: GO:0042656 +name: JUN kinase kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf] +synonym: "JUNKKKK activity" EXACT [] +is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity + +[Term] +id: GO:0042657 +name: MHC class II protein binding, via lateral surface +namespace: molecular_function +def: "Interacting selectively with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl] +synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT [] +is_a: GO:0042289 ! MHC class II protein binding + +[Term] +id: GO:0042658 +name: MHC class II protein binding, via antigen binding groove +namespace: molecular_function +def: "Interacting selectively with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl] +synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT [] +is_a: GO:0042289 ! MHC class II protein binding + +[Term] +id: GO:0042659 +name: regulation of cell fate specification +namespace: biological_process +def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] +is_a: GO:0010453 ! regulation of cell fate commitment +relationship: regulates GO:0001708 ! cell fate specification + +[Term] +id: GO:0042660 +name: positive regulation of cell fate specification +namespace: biological_process +def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators] +synonym: "activation of cell fate specification" NARROW [] +synonym: "stimulation of cell fate specification" NARROW [] +synonym: "up regulation of cell fate specification" EXACT [] +synonym: "up-regulation of cell fate specification" EXACT [] +synonym: "upregulation of cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0001708 ! cell fate specification + +[Term] +id: GO:0042661 +name: regulation of mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] +is_a: GO:0010470 ! regulation of gastrulation +is_a: GO:0042659 ! regulation of cell fate specification +relationship: regulates GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0042662 +name: negative regulation of mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] +synonym: "down regulation of mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of mesodermal cell fate specification" EXACT [] +synonym: "downregulation of mesodermal cell fate specification" EXACT [] +synonym: "inhibition of mesodermal cell fate specification" NARROW [] +synonym: "suppression of mesodermal cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0042663 +name: regulation of endodermal cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators] +synonym: "regulation of endoderm cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +relationship: regulates GO:0001714 ! endodermal cell fate specification + +[Term] +id: GO:0042664 +name: negative regulation of endodermal cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators] +synonym: "down regulation of endodermal cell fate specification" EXACT [] +synonym: "down-regulation of endodermal cell fate specification" EXACT [] +synonym: "downregulation of endodermal cell fate specification" EXACT [] +synonym: "inhibition of endodermal cell fate specification" NARROW [] +synonym: "negative regulation of endoderm cell fate specification" EXACT [] +synonym: "suppression of endoderm cell fate" EXACT [] +synonym: "suppression of endodermal cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042663 ! regulation of endodermal cell fate specification +relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification + +[Term] +id: GO:0042665 +name: regulation of ectodermal cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators] +synonym: "regulation of ectoderm cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001715 ! ectodermal cell fate specification + +[Term] +id: GO:0042666 +name: negative regulation of ectodermal cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators] +synonym: "down regulation of ectodermal cell fate specification" EXACT [] +synonym: "down-regulation of ectodermal cell fate specification" EXACT [] +synonym: "downregulation of ectodermal cell fate specification" EXACT [] +synonym: "inhibition of ectodermal cell fate specification" NARROW [] +synonym: "negative regulation of ectoderm cell fate specification" EXACT [] +synonym: "suppression of ectoderm cell fate" EXACT [] +synonym: "suppression of ectodermal cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042665 ! regulation of ectodermal cell fate specification +relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification + +[Term] +id: GO:0042667 +name: auditory receptor cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +synonym: "auditory hair cell fate specification" EXACT [] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0009912 ! auditory receptor cell fate commitment + +[Term] +id: GO:0042668 +name: auditory receptor cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "auditory hair cell fate determination" EXACT [] +is_a: GO:0048664 ! neuron fate determination +relationship: part_of GO:0009912 ! auditory receptor cell fate commitment + +[Term] +id: GO:0042669 +name: regulation of auditory receptor cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators] +synonym: "regulation of auditory hair cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0045607 ! regulation of auditory receptor cell differentiation +relationship: regulates GO:0042667 ! auditory receptor cell fate specification + +[Term] +id: GO:0042670 +name: retinal cone cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] +is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation + +[Term] +id: GO:0042671 +name: retinal cone cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0043703 ! photoreceptor cell fate determination +relationship: part_of GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0042672 +name: retinal cone cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +is_a: GO:0043704 ! photoreceptor cell fate specification +relationship: part_of GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0042673 +name: regulation of retinal cone cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0060222 ! regulation of retinal cone cell fate commitment +relationship: regulates GO:0042672 ! retinal cone cell fate specification + +[Term] +id: GO:0042675 +name: compound eye cone cell differentiation +namespace: biological_process +alt_id: GO:0042674 +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] +synonym: "cone cell differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0042676 +name: compound eye cone cell fate commitment +namespace: biological_process +alt_id: GO:0007466 +def: "The process whereby the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] +synonym: "cone cell fate commitment (sensu Endopterygota)" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0042675 ! compound eye cone cell differentiation + +[Term] +id: GO:0042679 +name: compound eye cone cell fate specification +namespace: biological_process +alt_id: GO:0042678 +def: "Process by which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu] +synonym: "cone cell fate specification (sensu Endopterygota)" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0042676 ! compound eye cone cell fate commitment + +[Term] +id: GO:0042680 +name: compound eye cone cell fate determination +namespace: biological_process +alt_id: GO:0042677 +def: "Process by which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] +synonym: "cone cell fate determination (sensu Endopterygota)" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0042676 ! compound eye cone cell fate commitment + +[Term] +id: GO:0042682 +name: regulation of compound eye cone cell fate specification +namespace: biological_process +alt_id: GO:0042681 +def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] +synonym: "regulation of cone cell fate specification (sensu Endopterygota)" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042679 ! compound eye cone cell fate specification + +[Term] +id: GO:0042683 +name: negative regulation of compound eye cone cell fate specification +namespace: biological_process +alt_id: GO:0010000 +def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu] +synonym: "down regulation of cone cell fate specification" EXACT [] +synonym: "down regulation of cone cell fate specification (sensu Endopterygota)" EXACT [] +synonym: "down-regulation of cone cell fate specification" EXACT [] +synonym: "down-regulation of cone cell fate specification (sensu Endopterygota)" EXACT [] +synonym: "downregulation of cone cell fate specification" EXACT [] +synonym: "downregulation of cone cell fate specification (sensu Endopterygota)" EXACT [] +synonym: "inhibition of cone cell fate specification" NARROW [] +synonym: "inhibition of cone cell fate specification (sensu Endopterygota)" NARROW [] +synonym: "negative regulation of cone cell fate specification (sensu Endopterygota)" EXACT [] +synonym: "suppression of cone cell fate (sensu Drosophila)" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042682 ! regulation of compound eye cone cell fate specification +relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification + +[Term] +id: GO:0042684 +name: cardioblast cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to becoming a cardioblast." [GOC:go_curators] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0042685 +name: cardioblast cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0042684 ! cardioblast cell fate commitment + +[Term] +id: GO:0042686 +name: regulation of cardioblast cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into a cardioblast." [GOC:go_curators] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0051890 ! regulation of cardioblast differentiation +relationship: regulates GO:0042685 ! cardioblast cell fate specification + +[Term] +id: GO:0042688 +name: crystal cell differentiation +namespace: biological_process +def: "The process by which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] +is_a: GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0042689 +name: regulation of crystal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: regulates GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0042690 +name: negative regulation of crystal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] +synonym: "down regulation of crystal cell differentiation" EXACT [] +synonym: "down-regulation of crystal cell differentiation" EXACT [] +synonym: "downregulation of crystal cell differentiation" EXACT [] +synonym: "inhibition of crystal cell differentiation" NARROW [] +is_a: GO:0042689 ! regulation of crystal cell differentiation +is_a: GO:0045611 ! negative regulation of hemocyte differentiation +relationship: negatively_regulates GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0042691 +name: positive regulation of crystal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] +synonym: "activation of crystal cell differentiation" NARROW [] +synonym: "stimulation of crystal cell differentiation" NARROW [] +synonym: "up regulation of crystal cell differentiation" EXACT [] +synonym: "up-regulation of crystal cell differentiation" EXACT [] +synonym: "upregulation of crystal cell differentiation" EXACT [] +is_a: GO:0042689 ! regulation of crystal cell differentiation +is_a: GO:0045612 ! positive regulation of hemocyte differentiation +relationship: positively_regulates GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0042692 +name: muscle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0042693 +name: muscle cell fate commitment +namespace: biological_process +def: "The process by which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0042694 +name: muscle cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0042693 ! muscle cell fate commitment + +[Term] +id: GO:0042695 +name: thelarche +namespace: biological_process +def: "The beginning of development of the breasts in the female." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0046543 ! development of secondary female sexual characteristics + +[Term] +id: GO:0042696 +name: menarche +namespace: biological_process +def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0022601 ! menstrual cycle phase +is_a: GO:0046543 ! development of secondary female sexual characteristics + +[Term] +id: GO:0042697 +name: menopause +namespace: biological_process +def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0022601 ! menstrual cycle phase +is_a: GO:0046543 ! development of secondary female sexual characteristics +relationship: part_of GO:0010259 ! multicellular organismal aging + +[Term] +id: GO:0042698 +name: ovulation cycle +namespace: biological_process +def: "The type of sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "estrous cycle" RELATED [] +synonym: "menstrual cycle" RELATED [] +is_a: GO:0048511 ! rhythmic process +is_a: GO:0048609 ! reproductive process in a multicellular organism + +[Term] +id: GO:0042699 +name: follicle-stimulating hormone signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by follicle-stimulating hormone." [GOC:dph] +synonym: "follicle stimulating hormone signaling pathway" EXACT [] +synonym: "follicle-stimulating hormone signalling pathway" EXACT [] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0042700 +name: luteinizing hormone signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by luteinizing hormone." [GOC:dph] +synonym: "luteinizing hormone signalling pathway" EXACT [] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0042701 +name: progesterone secretion +namespace: biological_process +def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0046879 ! hormone secretion +relationship: part_of GO:0001553 ! luteinization + +[Term] +id: GO:0042702 +name: uterine wall growth +namespace: biological_process +def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001553 ! luteinization + +[Term] +id: GO:0042703 +name: menstruation +namespace: biological_process +def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0022601 ! menstrual cycle phase + +[Term] +id: GO:0042704 +name: uterine wall breakdown +namespace: biological_process +def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0042703 ! menstruation + +[Term] +id: GO:0042705 +name: ocellus photoreceptor cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators] +is_a: GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0042706 +name: eye photoreceptor cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0046552 ! photoreceptor cell fate commitment +relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation + +[Term] +id: GO:0042707 +name: ocellus photoreceptor cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0046552 ! photoreceptor cell fate commitment +relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation + +[Term] +id: GO:0042708 +name: elastase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004175 + +[Term] +id: GO:0042709 +name: succinate-CoA ligase complex +namespace: cellular_component +def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl] +subset: gosubset_prok +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0042710 +name: biofilm formation +namespace: biological_process +def: "A process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [PMID:11932229] +subset: goslim_candida +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0042711 +name: maternal behavior +namespace: biological_process +def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators] +synonym: "maternal behaviour" EXACT [] +is_a: GO:0033057 ! reproductive behavior in a multicellular organism + +[Term] +id: GO:0042712 +name: paternal behavior +namespace: biological_process +def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators] +synonym: "paternal behaviour" EXACT [] +is_a: GO:0033057 ! reproductive behavior in a multicellular organism + +[Term] +id: GO:0042713 +name: sperm ejaculation +namespace: biological_process +def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0042714 +name: dosage compensation complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493] +is_a: GO:0034622 ! cellular macromolecular complex assembly +relationship: part_of GO:0007549 ! dosage compensation + +[Term] +id: GO:0042715 +name: dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes." [GOC:jl, PMID:11102361, PMID:12672493] +synonym: "dosage compensation complex assembly (sensu Nematoda)" EXACT [] +is_a: GO:0042714 ! dosage compensation complex assembly +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0042464 ! dosage compensation, by hypoactivation of X chromosome + +[Term] +id: GO:0042716 +name: plasma membrane-derived chromatophore +namespace: cellular_component +def: "A pigment-bearing structure found in certain photosynthetic bacteria and cyanobacteria which is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle." [GOC:jl, ISBN:0395825172, PMID:11867431] +comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin. +subset: gosubset_prok +synonym: "chromatophore vesicle" RELATED [] +synonym: "thylakoid (sensu Bacteria)" RELATED [] +synonym: "thylakoid (sensu Proteobacteria)" RELATED [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0042717 +name: plasma membrane-derived chromatophore membrane +namespace: cellular_component +def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431] +subset: gosubset_prok +is_a: GO:0034357 ! photosynthetic membrane +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0042718 +name: yolk granule +namespace: cellular_component +def: "Discrete structures that partition the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0042719 +name: mitochondrial intermembrane space protein transporter complex +namespace: cellular_component +def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629] +synonym: "Tim9-Tim10 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005758 ! mitochondrial intermembrane space + +[Term] +id: GO:0042720 +name: mitochondrial inner membrane peptidase complex +namespace: cellular_component +def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769] +synonym: "IMP" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0042721 +name: mitochondrial inner membrane protein insertion complex +namespace: cellular_component +def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765] +synonym: "Tim22 complex" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044455 ! mitochondrial membrane part +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0042722 +name: alpha-beta T cell activation by superantigen +namespace: biological_process +def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT [] +synonym: "alpha-beta T-cell activation by superantigen" EXACT [] +synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT [] +is_a: GO:0002287 ! alpha-beta T cell activation during immune response + +[Term] +id: GO:0042723 +name: thiamin and derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiamin (vitamin B1), and compounds derived from it." [GOC:jl] +subset: gosubset_prok +synonym: "thiamin and derivative metabolism" EXACT [] +synonym: "thiamine and derivative metabolic process" EXACT [] +synonym: "thiamine and derivative metabolism" EXACT [] +synonym: "vitamin B1 and derivative metabolic process" EXACT [] +synonym: "vitamin B1 and derivative metabolism" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process + +[Term] +id: GO:0042724 +name: thiamin and derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), and related compounds." [GOC:jl] +subset: gosubset_prok +synonym: "thiamin and derivative anabolism" EXACT [] +synonym: "thiamin and derivative biosynthesis" EXACT [] +synonym: "thiamin and derivative formation" EXACT [] +synonym: "thiamin and derivative synthesis" EXACT [] +synonym: "thiamine and derivative biosynthesis" EXACT [] +synonym: "thiamine and derivative biosynthetic process" EXACT [] +synonym: "vitamin B1 and derivative biosynthesis" EXACT [] +synonym: "vitamin B1 and derivative biosynthetic process" EXACT [] +is_a: GO:0042723 ! thiamin and derivative metabolic process + +[Term] +id: GO:0042725 +name: thiamin and derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), and compounds derived from it." [GOC:jl] +subset: gosubset_prok +synonym: "thiamin and derivative breakdown" EXACT [] +synonym: "thiamin and derivative catabolism" EXACT [] +synonym: "thiamin and derivative degradation" EXACT [] +synonym: "thiamine and derivative catabolic process" EXACT [] +synonym: "thiamine and derivative catabolism" EXACT [] +synonym: "vitamin B1 and derivative catabolic process" EXACT [] +synonym: "vitamin B1 and derivative catabolism" EXACT [] +is_a: GO:0042723 ! thiamin and derivative metabolic process + +[Term] +id: GO:0042726 +name: riboflavin and derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving riboflavin (vitamin B2) or any of its derivatives." [GOC:jl] +subset: gosubset_prok +synonym: "riboflavin and derivative metabolism" EXACT [] +synonym: "vitamin B2 and derivative metabolic process" EXACT [] +synonym: "vitamin B2 and derivative metabolism" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process + +[Term] +id: GO:0042727 +name: riboflavin and derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2) or any of its derivatives." [GOC:jl] +subset: gosubset_prok +synonym: "riboflavin and derivative anabolism" EXACT [] +synonym: "riboflavin and derivative biosynthesis" EXACT [] +synonym: "riboflavin and derivative formation" EXACT [] +synonym: "riboflavin and derivative synthesis" EXACT [] +synonym: "vitamin B2 and derivative biosynthesis" EXACT [] +synonym: "vitamin B2 and derivative biosynthetic process" EXACT [] +is_a: GO:0042726 ! riboflavin and derivative metabolic process + +[Term] +id: GO:0042728 +name: riboflavin and derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2) or any of its derivatives." [GOC:jl] +subset: gosubset_prok +synonym: "riboflavin and derivative breakdown" EXACT [] +synonym: "riboflavin and derivative catabolism" EXACT [] +synonym: "riboflavin and derivative degradation" EXACT [] +synonym: "vitamin B2 and derivative catabolic process" EXACT [] +synonym: "vitamin B2 and derivative catabolism" EXACT [] +is_a: GO:0042726 ! riboflavin and derivative metabolic process + +[Term] +id: GO:0042729 +name: DASH complex +namespace: cellular_component +def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complexes associate with kinetochores or microtubules and play a role spindle attachment, chromosome segregation and spindle stability." [GOC:jl, PMID:11782438, PMID:11799062] +comment: Note that this complex is conserved in fungi but has not been observed in metazoans. +synonym: "Dam1 complex" EXACT [] +synonym: "DDD complex" EXACT [] +synonym: "Duo1p-Dam1p-Dad1p complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0042730 +name: fibrinolysis +namespace: biological_process +def: "An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots." [GOC:jl, http://cancerweb.ncl.ac.uk/] +xref: Reactome:211639 +xref: Reactome:221411 +xref: Reactome:230046 +xref: Reactome:238064 +xref: Reactome:75205 +is_a: GO:0030195 ! negative regulation of blood coagulation + +[Term] +id: GO:0042731 +name: PH domain binding +namespace: molecular_function +def: "Interacting selectively with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0042732 +name: D-xylose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-xylose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0042733 +name: embryonic digit morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. Morphogenesis pertains to the creation of form. A digit is one of the terminal divisions of an appendage. For example a finger or toe." [GOC:bf, GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030326 ! embryonic limb morphogenesis + +[Term] +id: GO:0042734 +name: presynaptic membrane +namespace: cellular_component +def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0016020 ! membrane +is_a: GO:0044456 ! synapse part + +[Term] +id: GO:0042735 +name: protein body +namespace: cellular_component +def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0042736 +name: NADH kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NADH = ADP + NADPH." [PMID:12727869] +synonym: "ATP:NADH 2'-phosphotransferase activity" EXACT [EC:2.7.1.86] +synonym: "DPNH kinase activity" EXACT [EC:2.7.1.86] +synonym: "reduced diphosphopyridine nucleotide kinase activity" EXACT [EC:2.7.1.86] +synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.86] +xref: EC:2.7.1.86 +xref: MetaCyc:NADH-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0042737 +name: drug catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease." [GOC:go_curators] +subset: gosubset_prok +synonym: "drug breakdown" EXACT [] +synonym: "drug catabolism" EXACT [] +synonym: "drug degradation" EXACT [] +is_a: GO:0017144 ! drug metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042738 +name: exogenous drug catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." [GOC:jl] +subset: gosubset_prok +synonym: "exogenous drug breakdown" EXACT [] +synonym: "exogenous drug catabolism" EXACT [] +synonym: "exogenous drug degradation" EXACT [] +is_a: GO:0042737 ! drug catabolic process +relationship: part_of GO:0042493 ! response to drug + +[Term] +id: GO:0042739 +name: endogenous drug catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl] +subset: gosubset_prok +synonym: "endogenous drug breakdown" EXACT [] +synonym: "endogenous drug catabolism" EXACT [] +synonym: "endogenous drug degradation" EXACT [] +is_a: GO:0042737 ! drug catabolic process + +[Term] +id: GO:0042740 +name: exogenous antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl] +subset: gosubset_prok +synonym: "exogenous antibiotic breakdown" EXACT [] +synonym: "exogenous antibiotic catabolism" EXACT [] +synonym: "exogenous antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0042738 ! exogenous drug catabolic process +relationship: part_of GO:0046677 ! response to antibiotic + +[Term] +id: GO:0042741 +name: endogenous antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl] +subset: gosubset_prok +synonym: "endogenous antibiotic breakdown" EXACT [] +synonym: "endogenous antibiotic catabolism" EXACT [] +synonym: "endogenous antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0042739 ! endogenous drug catabolic process + +[Term] +id: GO:0042742 +name: defense response to bacterium +namespace: biological_process +alt_id: GO:0042830 +def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] +subset: gosubset_prok +synonym: "antibacterial peptide activity" RELATED [] +synonym: "defence response to bacteria" EXACT [] +synonym: "defence response to bacterium" EXACT [] +synonym: "defense response to bacteria" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0009617 ! response to bacterium + +[Term] +id: GO:0042743 +name: hydrogen peroxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/] +subset: gosubset_prok +synonym: "hydrogen peroxide metabolism" EXACT [] +is_a: GO:0006800 ! oxygen and reactive oxygen species metabolic process + +[Term] +id: GO:0042744 +name: hydrogen peroxide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] +subset: gosubset_prok +synonym: "hydrogen peroxide breakdown" EXACT [] +synonym: "hydrogen peroxide catabolism" EXACT [] +synonym: "hydrogen peroxide degradation" EXACT [] +synonym: "hydrogen peroxide removal" RELATED [] +is_a: GO:0042542 ! response to hydrogen peroxide +is_a: GO:0042743 ! hydrogen peroxide metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042745 +name: circadian sleep/wake cycle +namespace: biological_process +def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] +is_a: GO:0030431 ! sleep +is_a: GO:0048512 ! circadian behavior + +[Term] +id: GO:0042746 +name: circadian sleep/wake cycle, wakefulness +namespace: biological_process +def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468] +is_a: GO:0022410 ! circadian sleep/wake cycle process + +[Term] +id: GO:0042747 +name: circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172] +is_a: GO:0022410 ! circadian sleep/wake cycle process +relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0042748 +name: circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com] +is_a: GO:0022410 ! circadian sleep/wake cycle process +relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0042749 +name: regulation of circadian sleep/wake cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] +is_a: GO:0022410 ! circadian sleep/wake cycle process +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042745 ! circadian sleep/wake cycle + +[Term] +id: GO:0042750 +name: hibernation +namespace: biological_process +def: "Any process by which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0022611 ! dormancy process +is_a: GO:0030431 ! sleep + +[Term] +id: GO:0042751 +name: estivation +namespace: biological_process +def: "Any process by which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, http://www.wikipedia.org/] +is_a: GO:0022611 ! dormancy process +is_a: GO:0030431 ! sleep + +[Term] +id: GO:0042752 +name: regulation of circadian rhythm +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a circadian rhythm behavior." [GOC:jl] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0007623 ! circadian rhythm + +[Term] +id: GO:0042753 +name: positive regulation of circadian rhythm +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] +synonym: "activation of circadian rhythm" NARROW [] +synonym: "stimulation of circadian rhythm" NARROW [] +synonym: "up regulation of circadian rhythm" EXACT [] +synonym: "up-regulation of circadian rhythm" EXACT [] +synonym: "upregulation of circadian rhythm" EXACT [] +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0007623 ! circadian rhythm + +[Term] +id: GO:0042754 +name: negative regulation of circadian rhythm +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] +synonym: "down regulation of circadian rhythm" EXACT [] +synonym: "down-regulation of circadian rhythm" EXACT [] +synonym: "downregulation of circadian rhythm" EXACT [] +synonym: "inhibition of circadian rhythm" NARROW [] +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0007623 ! circadian rhythm + +[Term] +id: GO:0042755 +name: eating behavior +namespace: biological_process +def: "The specific actions or reactions of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, ISBN:01928006X] +synonym: "eating behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior + +[Term] +id: GO:0042756 +name: drinking behavior +namespace: biological_process +def: "The specific actions or reactions of an organism relating to the intake of liquids, especially water." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "drinking behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior + +[Term] +id: GO:0042757 +name: giant axon +namespace: cellular_component +def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0030424 ! axon + +[Term] +id: GO:0042758 +name: long-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:go_curators] +subset: gosubset_prok +synonym: "long-chain fatty acid breakdown" EXACT [] +synonym: "long-chain fatty acid catabolism" EXACT [] +synonym: "long-chain fatty acid degradation" EXACT [] +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0009062 ! fatty acid catabolic process + +[Term] +id: GO:0042759 +name: long-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:go_curators] +subset: gosubset_prok +synonym: "long-chain fatty acid anabolism" EXACT [] +synonym: "long-chain fatty acid biosynthesis" EXACT [] +synonym: "long-chain fatty acid formation" EXACT [] +synonym: "long-chain fatty acid synthesis" EXACT [] +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0042760 +name: very-long-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of C18 or greater." [GOC:go_curators] +subset: gosubset_prok +synonym: "very-long-chain fatty acid breakdown" EXACT [] +synonym: "very-long-chain fatty acid catabolism" EXACT [] +synonym: "very-long-chain fatty acid degradation" EXACT [] +is_a: GO:0000038 ! very-long-chain fatty acid metabolic process +is_a: GO:0009062 ! fatty acid catabolic process + +[Term] +id: GO:0042761 +name: very-long-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of C18 or greater." [GOC:go_curators] +subset: gosubset_prok +synonym: "very-long-chain fatty acid anabolism" EXACT [] +synonym: "very-long-chain fatty acid biosynthesis" EXACT [] +synonym: "very-long-chain fatty acid formation" EXACT [] +synonym: "very-long-chain fatty acid synthesis" EXACT [] +xref: MetaCyc:PWY-5080 +is_a: GO:0000038 ! very-long-chain fatty acid metabolic process +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0042762 +name: regulation of sulfur metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of sulfur metabolism" EXACT [] +synonym: "regulation of sulphur metabolic process" EXACT [] +synonym: "regulation of sulphur metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0042763 +name: intracellular immature spore +namespace: cellular_component +def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172] +subset: gosubset_prok +synonym: "forespore" RELATED [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0042764 +name: ascospore-type prospore +namespace: cellular_component +def: "An immature spore, of the type observed in ascopore-forming fungi, undergoing development; usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s)." [GOC:go_curators] +subset: gosubset_prok +synonym: "forespore (sensu Fungi)" BROAD [] +is_a: GO:0042763 ! intracellular immature spore + +[Term] +id: GO:0042765 +name: GPI-anchor transamidase complex +namespace: cellular_component +def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] +comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. +synonym: "GPIT complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane + +[Term] +id: GO:0042766 +name: nucleosome mobilization +namespace: biological_process +def: "The movement of nucleosomes along a DNA fragment." [PMID:12006495] +is_a: GO:0006338 ! chromatin remodeling +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0042767 +name: ecdysteroid 22-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427] +comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone. +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0042768 +name: ecdysteroid 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427] +comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone. +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0042769 +name: DNA damage response, detection of DNA damage +namespace: biological_process +def: "The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators] +synonym: "detection of DNA damage during DNA damage response" EXACT [] +synonym: "DNA damage response, perception of DNA damage" RELATED [] +is_a: GO:0006974 ! response to DNA damage stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0042770 +name: DNA damage response, signal transduction +namespace: biological_process +def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] +is_a: GO:0007242 ! intracellular signaling cascade +is_a: GO:0034984 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0042771 +name: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis +namespace: biological_process +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death)." [GOC:go_curators] +is_a: GO:0008630 ! DNA damage response, signal transduction resulting in induction of apoptosis +is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0042772 +name: DNA damage response, signal transduction resulting in transcription +namespace: biological_process +def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators] +is_a: GO:0042770 ! DNA damage response, signal transduction + +[Term] +id: GO:0042773 +name: ATP synthesis coupled electron transport +namespace: biological_process +def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] +subset: gosubset_prok +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0042774 +name: plasma membrane ATP synthesis coupled electron transport +namespace: biological_process +def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mtg_sensu, ISBN:0716731363] +subset: gosubset_prok +synonym: "ATP synthesis coupled electron transport (sensu Bacteria)" EXACT [] +is_a: GO:0042773 ! ATP synthesis coupled electron transport + +[Term] +id: GO:0042775 +name: mitochondrial ATP synthesis coupled electron transport +namespace: biological_process +def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane; as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759)." [GOC:mtg_sensu, ISBN:0716731363] +synonym: "ATP synthesis coupled electron transport (sensu Eukaryota)" EXACT [] +synonym: "mitochondrial electron transport" BROAD [] +synonym: "organelle ATP synthesis coupled electron transport" BROAD [] +xref: Reactome:163200 +xref: Reactome:211785 +xref: Reactome:221550 +xref: Reactome:238190 +xref: Reactome:244866 +xref: Reactome:249757 +xref: Reactome:252505 +xref: Reactome:255678 +xref: Reactome:259073 +xref: Reactome:262433 +xref: Reactome:265268 +xref: Reactome:268394 +xref: Reactome:274107 +xref: Reactome:280580 +xref: Reactome:286598 +xref: Reactome:289827 +xref: Reactome:291739 +xref: Reactome:293717 +is_a: GO:0042773 ! ATP synthesis coupled electron transport + +[Term] +id: GO:0042776 +name: mitochondrial ATP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] +synonym: "ATP synthesis coupled proton transport (sensu Eukaryota)" EXACT [] +synonym: "mitochondrial proton transport" BROAD [] +xref: Reactome:163210 +xref: Reactome:164834 +xref: Reactome:207824 +xref: Reactome:211634 +xref: Reactome:217352 +xref: Reactome:221406 +xref: Reactome:226025 +xref: Reactome:230041 +xref: Reactome:234734 +xref: Reactome:238059 +xref: Reactome:242406 +xref: Reactome:244673 +xref: Reactome:247656 +xref: Reactome:249603 +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015986 ! ATP synthesis coupled proton transport + +[Term] +id: GO:0042777 +name: plasma membrane ATP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] +subset: gosubset_prok +synonym: "ATP synthesis coupled proton transport (sensu Bacteria)" EXACT [] +is_a: GO:0015986 ! ATP synthesis coupled proton transport + +[Term] +id: GO:0042778 +name: tRNA end turnover +namespace: biological_process +def: "Process by which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006399 ! tRNA metabolic process + +[Term] +id: GO:0042779 +name: tRNA 3'-trailer cleavage +namespace: biological_process +def: "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators] +subset: gosubset_prok +synonym: "removal of tRNA 3'-trailer sequence" EXACT [] +synonym: "tRNA 3'-end cleavage" EXACT [] +is_a: GO:0042780 ! tRNA 3'-end processing + +[Term] +id: GO:0042780 +name: tRNA 3'-end processing +namespace: biological_process +def: "The process by which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "tRNA 3' processing" EXACT [] +is_a: GO:0008033 ! tRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0042781 +name: 3'-tRNA processing endoribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11] +subset: gosubset_prok +synonym: "3 tRNase activity" EXACT [EC:3.1.26.11] +synonym: "3' tRNA processing endoribonuclease activity" EXACT [] +synonym: "3' tRNase activity" BROAD [] +synonym: "ribonuclease Z activity" BROAD [] +synonym: "RNase Z activity" BROAD [] +synonym: "tRNA 3 endonuclease activity" EXACT [EC:3.1.26.11] +synonym: "tRNA 3' endonuclease activity" EXACT [] +synonym: "tRNase Z" RELATED [EC:3.1.26.11] +synonym: "tRNAse Z" RELATED [EC:3.1.26.11] +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0042782 +name: passive evasion of host immune response +namespace: biological_process +def: "Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] +subset: gosubset_prok +synonym: "passive immune evasion" BROAD [] +is_a: GO:0020012 ! evasion or tolerance of host immune response +is_a: GO:0051809 ! passive evasion of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0042783 +name: active evasion of host immune response +namespace: biological_process +def: "Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] +subset: gosubset_prok +synonym: "active immune evasion" BROAD [] +is_a: GO:0020012 ! evasion or tolerance of host immune response +is_a: GO:0051810 ! active evasion of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0042784 +name: active evasion of host immune response via regulation of host complement system +namespace: biological_process +def: "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] +synonym: "active immune evasion via modulation of host complement system" EXACT [] +synonym: "active immune evasion via regulation of host complement system" EXACT [] +is_a: GO:0042783 ! active evasion of host immune response +is_a: GO:0051811 ! active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction + +[Term] +id: GO:0042785 +name: active evasion of host immune response via regulation of host cytokine network +namespace: biological_process +def: "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] +synonym: "active immune evasion via modulation of host cytokine network" EXACT [] +synonym: "active immune evasion via regulation of host cytokine network" EXACT [] +is_a: GO:0042783 ! active evasion of host immune response +is_a: GO:0051812 ! active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction + +[Term] +id: GO:0042786 +name: active evasion of host immune response via regulation of host antigen processing and presentation +namespace: biological_process +def: "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] +synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT [] +synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT [] +synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT [] +synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT [] +is_a: GO:0042783 ! active evasion of host immune response + +[Term] +id: GO:0042787 +name: protein ubiquitination during ubiquitin-dependent protein catabolic process +namespace: biological_process +alt_id: GO:0043432 +def: "The process by which a ubiquitin moiety, or multiple moieties, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] +synonym: "protein degradation tagging activity" RELATED [] +synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [] +synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [] +synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [] +synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [] +synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [] +xref: Reactome:174057 +xref: Reactome:174104 +xref: Reactome:174144 +xref: Reactome:174195 +xref: Reactome:174227 +xref: Reactome:209560 +xref: Reactome:211380 +xref: Reactome:211382 +xref: Reactome:211384 +xref: Reactome:211389 +xref: Reactome:219296 +xref: Reactome:221183 +xref: Reactome:221185 +xref: Reactome:221187 +xref: Reactome:221192 +xref: Reactome:228104 +xref: Reactome:229823 +xref: Reactome:229825 +xref: Reactome:229827 +xref: Reactome:229832 +xref: Reactome:236320 +xref: Reactome:237846 +xref: Reactome:237848 +xref: Reactome:237850 +xref: Reactome:237855 +xref: Reactome:243467 +xref: Reactome:244512 +xref: Reactome:244514 +xref: Reactome:244516 +xref: Reactome:244521 +xref: Reactome:262203 +xref: Reactome:262205 +xref: Reactome:265030 +xref: Reactome:268144 +xref: Reactome:268146 +xref: Reactome:273124 +xref: Reactome:273806 +xref: Reactome:273808 +xref: Reactome:273810 +xref: Reactome:273811 +xref: Reactome:279606 +xref: Reactome:280273 +xref: Reactome:280275 +xref: Reactome:280277 +xref: Reactome:280278 +xref: Reactome:285680 +xref: Reactome:286333 +xref: Reactome:286335 +xref: Reactome:286337 +xref: Reactome:286340 +is_a: GO:0016567 ! protein ubiquitination +relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0042788 +name: polysomal ribosome +namespace: cellular_component +def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl] +synonym: "active ribosome" BROAD [] +is_a: GO:0005840 ! ribosome +relationship: part_of GO:0005844 ! polysome + +[Term] +id: GO:0042789 +name: mRNA transcription from RNA polymerase II promoter +namespace: biological_process +def: "The synthesis of messenger RNA (mRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:jl, ISBN:0321000382] +synonym: "mRNA transcription from Pol II promoter" EXACT [] +is_a: GO:0006366 ! transcription from RNA polymerase II promoter +is_a: GO:0009299 ! mRNA transcription + +[Term] +id: GO:0042790 +name: transcription of nuclear rRNA large RNA polymerase I transcript +namespace: biological_process +def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template." [GOC:jl, ISBN:0321000382] +synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT [] +is_a: GO:0006360 ! transcription from RNA polymerase I promoter +is_a: GO:0009303 ! rRNA transcription + +[Term] +id: GO:0042791 +name: 5S class rRNA transcription +namespace: biological_process +def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template." [GOC:jl, ISBN:0321000382] +subset: gosubset_prok +synonym: "5S rRNA transcription" EXACT [] +is_a: GO:0006383 ! transcription from RNA polymerase III promoter +is_a: GO:0009303 ! rRNA transcription + +[Term] +id: GO:0042792 +name: rRNA transcription from mitochondrial promoter +namespace: biological_process +def: "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382] +is_a: GO:0006390 ! transcription from mitochondrial promoter +is_a: GO:0009303 ! rRNA transcription + +[Term] +id: GO:0042793 +name: transcription from plastid promoter +namespace: biological_process +def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] +synonym: "plastid transcription" EXACT [] +is_a: GO:0006351 ! transcription, DNA-dependent +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0042794 +name: rRNA transcription from plastid promoter +namespace: biological_process +def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] +is_a: GO:0009303 ! rRNA transcription +is_a: GO:0042793 ! transcription from plastid promoter + +[Term] +id: GO:0042795 +name: snRNA transcription from RNA polymerase II promoter +namespace: biological_process +def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] +synonym: "snRNA transcription from Pol II promoter" EXACT [] +is_a: GO:0006366 ! transcription from RNA polymerase II promoter +is_a: GO:0009301 ! snRNA transcription + +[Term] +id: GO:0042796 +name: snRNA transcription from RNA polymerase III promoter +namespace: biological_process +def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] +synonym: "snRNA transcription from Pol III promoter" EXACT [] +is_a: GO:0006383 ! transcription from RNA polymerase III promoter +is_a: GO:0009301 ! snRNA transcription + +[Term] +id: GO:0042797 +name: tRNA transcription from RNA polymerase III promoter +namespace: biological_process +def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] +synonym: "tRNA transcription from Pol III promoter" EXACT [] +is_a: GO:0006383 ! transcription from RNA polymerase III promoter +is_a: GO:0009304 ! tRNA transcription + +[Term] +id: GO:0042798 +name: protein neddylation during NEDD8 class-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl] +comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. +synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT [] +synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT [] +synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT [] +synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT [] +synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT [] +is_obsolete: true +consider: GO:0045116 + +[Term] +id: GO:0042799 +name: histone lysine N-methyltransferase activity (H4-K20 specific) +namespace: molecular_function +def: "Catalysis of the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] +comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies. +synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT [] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0042800 +name: histone lysine N-methyltransferase activity (H3-K4 specific) +namespace: molecular_function +def: "Catalysis of the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12589755] +comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. +synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT [] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0042801 +name: polo kinase kinase activity +namespace: molecular_function +def: "Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma] +is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity + +[Term] +id: GO:0042802 +name: identical protein binding +namespace: molecular_function +def: "Interacting selectively with an identical protein or proteins." [GOC:jl] +subset: gosubset_prok +synonym: "protein homopolymerization" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042803 +name: protein homodimerization activity +namespace: molecular_function +def: "Interacting selectively with an identical protein to form a homodimer." [GOC:jl] +subset: gosubset_prok +synonym: "dimerization activity" BROAD [] +is_a: GO:0042802 ! identical protein binding +is_a: GO:0046983 ! protein dimerization activity + +[Term] +id: GO:0042804 +name: protein homooligomerization activity +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl] +comment: This term was made obsolete because it represents a biological process. +synonym: "oligomerization activity" BROAD [] +is_obsolete: true +replaced_by: GO:0051260 + +[Term] +id: GO:0042805 +name: actinin binding +namespace: molecular_function +def: "Interacting selectively with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0042806 +name: fucose binding +namespace: molecular_function +def: "Interacting selectively with fucose, the pentose 6-deoxygalactose." [ChEBI:33984, ISBN:0582227089] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0042807 +name: central vacuole +namespace: cellular_component +def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [http://www.wikipedia.org/] +is_a: GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0042808 +name: neuronal Cdc2-like kinase binding +namespace: molecular_function +def: "Interacting selectively with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0042809 +name: vitamin D receptor binding +namespace: molecular_function +def: "Interacting selectively with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, UniProtKB:P11473] +synonym: "calciferol receptor binding" EXACT [] +synonym: "VDR binding" EXACT [] +is_a: GO:0008134 ! transcription factor binding +is_a: GO:0035257 ! nuclear hormone receptor binding + +[Term] +id: GO:0042810 +name: pheromone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "pheromone metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0042811 +name: pheromone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pheromone anabolism" EXACT [] +synonym: "pheromone biosynthesis" EXACT [] +synonym: "pheromone formation" EXACT [] +synonym: "pheromone synthesis" EXACT [] +is_a: GO:0042810 ! pheromone metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042812 +name: pheromone catabolic process +namespace: biological_process +alt_id: GO:0007327 +alt_id: GO:0046614 +def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pheromone breakdown" EXACT [] +synonym: "pheromone catabolism" EXACT [] +synonym: "pheromone degradation" EXACT [] +is_a: GO:0042810 ! pheromone metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042813 +name: Wnt receptor activity +namespace: molecular_function +def: "Combining with a member of the Wnt family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] +synonym: "frizzled receptor activity" RELATED [] +synonym: "frizzled-2 receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0042814 +name: monopolar cell growth +namespace: biological_process +def: "Polarized growth from one end of a cell." [GOC:vw] +synonym: "monopolar cell elongation" NARROW [] +synonym: "monopolar growth" BROAD [] +synonym: "polar cell elongation" NARROW [] +is_a: GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0042815 +name: bipolar cell growth +namespace: biological_process +def: "Simultaneous polarized growth from opposite ends of a cell." [GOC:vw] +synonym: "bipolar cell elongation" NARROW [] +synonym: "bipolar growth" BROAD [] +synonym: "polar cell elongation" RELATED [] +is_a: GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0042816 +name: vitamin B6 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "vitamin B6 metabolism" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process + +[Term] +id: GO:0042817 +name: pyridoxal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/] +subset: gosubset_prok +synonym: "pyridoxal metabolism" EXACT [] +is_a: GO:0042816 ! vitamin B6 metabolic process + +[Term] +id: GO:0042818 +name: pyridoxamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "pyridoxamine metabolism" EXACT [] +is_a: GO:0042816 ! vitamin B6 metabolic process + +[Term] +id: GO:0042819 +name: vitamin B6 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "vitamin B6 anabolism" EXACT [] +synonym: "vitamin B6 biosynthesis" EXACT [] +synonym: "vitamin B6 formation" EXACT [] +synonym: "vitamin B6 synthesis" EXACT [] +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042816 ! vitamin B6 metabolic process + +[Term] +id: GO:0042820 +name: vitamin B6 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +subset: gosubset_prok +synonym: "vitamin B6 breakdown" EXACT [] +synonym: "vitamin B6 catabolism" EXACT [] +synonym: "vitamin B6 degradation" EXACT [] +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042816 ! vitamin B6 metabolic process + +[Term] +id: GO:0042821 +name: pyridoxal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/] +subset: gosubset_prok +synonym: "pyridoxal anabolism" EXACT [] +synonym: "pyridoxal biosynthesis" EXACT [] +synonym: "pyridoxal formation" EXACT [] +synonym: "pyridoxal synthesis" EXACT [] +is_a: GO:0042817 ! pyridoxal metabolic process +is_a: GO:0042819 ! vitamin B6 biosynthetic process + +[Term] +id: GO:0042822 +name: pyridoxal phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] +subset: gosubset_prok +synonym: "active vitamin B6 metabolic process" EXACT [] +synonym: "active vitamin B6 metabolism" EXACT [] +synonym: "pyridoxal phosphate metabolism" EXACT [] +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0042823 +name: pyridoxal phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] +subset: gosubset_prok +synonym: "active vitamin B6 biosynthesis" EXACT [] +synonym: "active vitamin B6 biosynthetic process" EXACT [] +synonym: "pyridoxal phosphate anabolism" EXACT [] +synonym: "pyridoxal phosphate biosynthesis" EXACT [] +synonym: "pyridoxal phosphate formation" EXACT [] +synonym: "pyridoxal phosphate synthesis" EXACT [] +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0042819 ! vitamin B6 biosynthetic process +is_a: GO:0042822 ! pyridoxal phosphate metabolic process + +[Term] +id: GO:0042824 +name: MHC class I peptide loading complex +namespace: cellular_component +def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] +comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi. +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0042825 +name: TAP complex +namespace: cellular_component +def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934] +synonym: "transporter associated with antigen presentation" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0042824 ! MHC class I peptide loading complex + +[Term] +id: GO:0042826 +name: histone deacetylase binding +namespace: molecular_function +def: "Interacting selectively with the enzyme histone deacetylase." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0042827 +name: platelet dense granule +namespace: cellular_component +def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378] +synonym: "bull's eye body" EXACT [] +synonym: "platelet dense body" EXACT [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042832 +name: defense response to protozoan +namespace: biological_process +def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl] +synonym: "defence response to pathogenic protozoa" EXACT [] +synonym: "defence response to protozoa" EXACT [] +synonym: "defence response to protozoon" EXACT [] +synonym: "defense response to pathogenic protozoa" EXACT [] +synonym: "defense response to protozoa" EXACT [] +synonym: "defense response to protozoon" EXACT [] +is_a: GO:0001562 ! response to protozoan +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0042834 +name: peptidoglycan binding +namespace: molecular_function +def: "Interacting selectively, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] +subset: gosubset_prok +is_a: GO:0001871 ! pattern binding + +[Term] +id: GO:0042835 +name: BRE binding +namespace: molecular_function +def: "Interacting selectively with the RNA element BRE (Bruno response element)." [PMID:10893231] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0042836 +name: D-glucarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glucarate, the dextrorotatory isomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-glucarate metabolism" EXACT [] +synonym: "saccharate metabolic process" EXACT [] +synonym: "saccharate metabolism" EXACT [] +is_a: GO:0019392 ! glucarate metabolic process + +[Term] +id: GO:0042837 +name: D-glucarate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the dextrorotatory isomer of glucarate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-glucarate anabolism" EXACT [] +synonym: "D-glucarate biosynthesis" EXACT [] +synonym: "D-glucarate formation" EXACT [] +synonym: "D-glucarate synthesis" EXACT [] +synonym: "saccharate biosynthesis" EXACT [] +synonym: "saccharate biosynthetic process" EXACT [] +is_a: GO:0019393 ! glucarate biosynthetic process +is_a: GO:0042836 ! D-glucarate metabolic process + +[Term] +id: GO:0042838 +name: D-glucarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the dextrorotatory isomer of glucarate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-glucarate breakdown" EXACT [] +synonym: "D-glucarate catabolism" EXACT [] +synonym: "D-glucarate degradation" EXACT [] +synonym: "saccharate catabolic process" EXACT [] +synonym: "saccharate catabolism" EXACT [] +is_a: GO:0019394 ! glucarate catabolic process +is_a: GO:0042836 ! D-glucarate metabolic process + +[Term] +id: GO:0042839 +name: D-glucuronate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glucuronate, the dextrorotatory isomer of glucuronate." [GOC:jl] +subset: gosubset_prok +synonym: "D-glucuronate metabolism" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process + +[Term] +id: GO:0042840 +name: D-glucuronate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the dextrorotatory isomer of glucuronate." [GOC:jl] +subset: gosubset_prok +synonym: "D-glucuronate breakdown" EXACT [] +synonym: "D-glucuronate catabolism" EXACT [] +synonym: "D-glucuronate degradation" EXACT [] +is_a: GO:0006064 ! glucuronate catabolic process +is_a: GO:0042839 ! D-glucuronate metabolic process + +[Term] +id: GO:0042841 +name: D-glucuronate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the dextrorotatory isomer of glucuronate." [GOC:jl] +subset: gosubset_prok +synonym: "D-glucuronate anabolism" EXACT [] +synonym: "D-glucuronate biosynthesis" EXACT [] +synonym: "D-glucuronate formation" EXACT [] +synonym: "D-glucuronate synthesis" EXACT [] +is_a: GO:0042839 ! D-glucuronate metabolic process +is_a: GO:0046399 ! glucuronate biosynthetic process + +[Term] +id: GO:0042842 +name: D-xylose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-xylose anabolism" EXACT [] +synonym: "D-xylose biosynthesis" EXACT [] +synonym: "D-xylose formation" EXACT [] +synonym: "D-xylose synthesis" EXACT [] +is_a: GO:0042732 ! D-xylose metabolic process + +[Term] +id: GO:0042843 +name: D-xylose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-xylose breakdown" EXACT [] +synonym: "D-xylose catabolism" EXACT [] +synonym: "D-xylose degradation" EXACT [] +is_a: GO:0042732 ! D-xylose metabolic process + +[Term] +id: GO:0042844 +name: glycol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/] +subset: gosubset_prok +synonym: "dihydric alcohol metabolic process" BROAD [] +synonym: "dihydric alcohol metabolism" BROAD [] +synonym: "glycol metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:0042845 +name: glycol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/] +subset: gosubset_prok +synonym: "dihydric alcohol biosynthesis" BROAD [] +synonym: "dihydric alcohol biosynthetic process" BROAD [] +synonym: "glycol anabolism" EXACT [] +synonym: "glycol biosynthesis" EXACT [] +synonym: "glycol formation" EXACT [] +synonym: "glycol synthesis" EXACT [] +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0042844 ! glycol metabolic process + +[Term] +id: GO:0042846 +name: glycol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/] +subset: gosubset_prok +synonym: "dihydric alcohol catabolic process" BROAD [] +synonym: "dihydric alcohol catabolism" BROAD [] +synonym: "glycol breakdown" EXACT [] +synonym: "glycol catabolism" EXACT [] +synonym: "glycol degradation" EXACT [] +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0042844 ! glycol metabolic process + +[Term] +id: GO:0042847 +name: sorbose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sorbose anabolism" EXACT [] +synonym: "sorbose biosynthesis" EXACT [] +synonym: "sorbose formation" EXACT [] +synonym: "sorbose synthesis" EXACT [] +is_a: GO:0019311 ! sorbose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0042848 +name: sorbose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sorbose breakdown" EXACT [] +synonym: "sorbose catabolism" EXACT [] +synonym: "sorbose degradation" EXACT [] +is_a: GO:0019311 ! sorbose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0042849 +name: L-sorbose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the levorotatory isomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-sorbose anabolism" EXACT [] +synonym: "L-sorbose biosynthesis" EXACT [] +synonym: "L-sorbose formation" EXACT [] +synonym: "L-sorbose synthesis" EXACT [] +is_a: GO:0019312 ! L-sorbose metabolic process +is_a: GO:0042847 ! sorbose biosynthetic process + +[Term] +id: GO:0042850 +name: L-sorbose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the levorotatory isomer of the ketohexose xylo-2-hexulose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-sorbose breakdown" EXACT [] +synonym: "L-sorbose catabolism" EXACT [] +synonym: "L-sorbose degradation" EXACT [] +is_a: GO:0019312 ! L-sorbose metabolic process +is_a: GO:0042848 ! sorbose catabolic process + +[Term] +id: GO:0042851 +name: L-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-alanine, the levorotatory isomer of 2-aminopropanoic acid." [GOC:jl] +subset: gosubset_prok +synonym: "L-alanine metabolism" EXACT [] +is_a: GO:0006522 ! alanine metabolic process + +[Term] +id: GO:0042852 +name: L-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-alanine, the levorotatory isomer of 2-aminopropanoic acid." [GOC:jl] +subset: gosubset_prok +synonym: "L-alanine anabolism" EXACT [] +synonym: "L-alanine biosynthesis" EXACT [] +synonym: "L-alanine formation" EXACT [] +synonym: "L-alanine synthesis" EXACT [] +is_a: GO:0006523 ! alanine biosynthetic process +is_a: GO:0042851 ! L-alanine metabolic process + +[Term] +id: GO:0042853 +name: L-alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the levorotatory isomer of 2-aminopropanoic acid." [GOC:jl] +subset: gosubset_prok +synonym: "L-alanine breakdown" EXACT [] +synonym: "L-alanine catabolism" EXACT [] +synonym: "L-alanine degradation" EXACT [] +is_a: GO:0006524 ! alanine catabolic process +is_a: GO:0042851 ! L-alanine metabolic process + +[Term] +id: GO:0042854 +name: eugenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT [] +synonym: "4-allyl-2-methoxyphenol metabolism" EXACT [] +synonym: "eugenic acid metabolic process" EXACT [] +synonym: "eugenic acid metabolism" EXACT [] +synonym: "eugenol metabolism" EXACT [] +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0042855 +name: eugenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT [] +synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT [] +synonym: "eugenic acid biosynthesis" EXACT [] +synonym: "eugenic acid biosynthetic process" EXACT [] +synonym: "eugenol anabolism" EXACT [] +synonym: "eugenol biosynthesis" EXACT [] +synonym: "eugenol formation" EXACT [] +synonym: "eugenol synthesis" EXACT [] +is_a: GO:0042854 ! eugenol metabolic process +is_a: GO:0046189 ! phenol biosynthetic process + +[Term] +id: GO:0042856 +name: eugenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT [] +synonym: "4-allyl-2-methoxyphenol catabolism" EXACT [] +synonym: "eugenic acid catabolic process" EXACT [] +synonym: "eugenic acid catabolism" EXACT [] +synonym: "eugenol breakdown" EXACT [] +synonym: "eugenol catabolism" EXACT [] +synonym: "eugenol degradation" EXACT [] +is_a: GO:0019336 ! phenol catabolic process +is_a: GO:0042854 ! eugenol metabolic process + +[Term] +id: GO:0042857 +name: chrysobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] +subset: gosubset_prok +synonym: "chrysobactin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0042858 +name: chrysobactin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] +subset: gosubset_prok +synonym: "chrysobactin anabolism" EXACT [] +synonym: "chrysobactin biosynthesis" EXACT [] +synonym: "chrysobactin formation" EXACT [] +synonym: "chrysobactin synthesis" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0042857 ! chrysobactin metabolic process + +[Term] +id: GO:0042859 +name: chrysobactin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] +subset: gosubset_prok +synonym: "chrysobactin breakdown" EXACT [] +synonym: "chrysobactin catabolism" EXACT [] +synonym: "chrysobactin degradation" EXACT [] +is_a: GO:0042857 ! chrysobactin metabolic process +is_a: GO:0046215 ! siderophore catabolic process + +[Term] +id: GO:0042860 +name: achromobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] +subset: gosubset_prok +synonym: "achromobactin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0042861 +name: achromobactin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] +subset: gosubset_prok +synonym: "achromobactin anabolism" EXACT [] +synonym: "achromobactin biosynthesis" EXACT [] +synonym: "achromobactin formation" EXACT [] +synonym: "achromobactin synthesis" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0042860 ! achromobactin metabolic process + +[Term] +id: GO:0042862 +name: achromobactin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] +subset: gosubset_prok +synonym: "achromobactin breakdown" EXACT [] +synonym: "achromobactin catabolism" EXACT [] +synonym: "achromobactin degradation" EXACT [] +is_a: GO:0042860 ! achromobactin metabolic process +is_a: GO:0046215 ! siderophore catabolic process + +[Term] +id: GO:0042863 +name: pyochelin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] +subset: gosubset_prok +synonym: "pyochelin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0042864 +name: pyochelin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] +subset: gosubset_prok +synonym: "pyochelin anabolism" EXACT [] +synonym: "pyochelin biosynthesis" EXACT [] +synonym: "pyochelin formation" EXACT [] +synonym: "pyochelin synthesis" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0042863 ! pyochelin metabolic process + +[Term] +id: GO:0042865 +name: pyochelin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] +subset: gosubset_prok +synonym: "pyochelin breakdown" EXACT [] +synonym: "pyochelin catabolism" EXACT [] +synonym: "pyochelin degradation" EXACT [] +is_a: GO:0042863 ! pyochelin metabolic process +is_a: GO:0046215 ! siderophore catabolic process + +[Term] +id: GO:0042866 +name: pyruvate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyruvate anabolism" EXACT [] +synonym: "pyruvate biosynthesis" EXACT [] +synonym: "pyruvate formation" EXACT [] +synonym: "pyruvate synthesis" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0042867 +name: pyruvate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators] +subset: gosubset_prok +synonym: "pyruvate breakdown" EXACT [] +synonym: "pyruvate catabolism" EXACT [] +synonym: "pyruvate degradation" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0042868 +name: antisense RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "antisense RNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0042869 +name: aldarate transport +namespace: biological_process +def: "The directed movement of aldarate into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0042870 +name: D-glucarate transport +namespace: biological_process +def: "The directed movement of D-glucarate, the dextrorotatory isomer of glucarate, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042869 ! aldarate transport + +[Term] +id: GO:0042871 +name: D-galactarate transport +namespace: biological_process +def: "The directed movement of D-galactarate into, out of, within or between cells. D-galactarate is the dextrorotatory isomer of galactarate, the anion of galactaric acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0042869 ! aldarate transport + +[Term] +id: GO:0042872 +name: D-galactarate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-galactarate anabolism" EXACT [] +synonym: "D-galactarate biosynthesis" EXACT [] +synonym: "D-galactarate formation" EXACT [] +synonym: "D-galactarate synthesis" EXACT [] +is_a: GO:0046357 ! galactarate biosynthetic process +is_a: GO:0046393 ! D-galactarate metabolic process + +[Term] +id: GO:0042873 +name: aldonate transport +namespace: biological_process +def: "The directed movement of aldonate into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0008645 ! hexose transport + +[Term] +id: GO:0042874 +name: D-glucuronate transport +namespace: biological_process +def: "The directed movement of D-glucuronate, the dextrorotatory isomer of glucuronate into, out of, within or between cells." [GOC:jl] +is_a: GO:0042873 ! aldonate transport + +[Term] +id: GO:0042875 +name: D-galactonate transport +namespace: biological_process +def: "The directed movement of D-galactonate, the dextrorotatory isomer of galactonate, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042873 ! aldonate transport + +[Term] +id: GO:0042876 +name: aldarate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of aldarate from one side of the membrane to the other." [GOC:go_curators, PMID:15034926] +subset: gosubset_prok +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0042877 +name: D-galactarate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-galactarate, the dextrorotatory isomer of the anion of galactaric acid, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0042876 ! aldarate transmembrane transporter activity + +[Term] +id: GO:0042878 +name: D-glucarate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-glucarate, the dextrorotatory isomer of glucarate, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0042876 ! aldarate transmembrane transporter activity + +[Term] +id: GO:0042879 +name: aldonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of aldonate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0042880 +name: D-glucuronate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-glucuronate, the dextrorotatory isomer of glucuronate, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:0042881 +name: D-galactonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-galactonate, the dextrorotatory isomer of galactonate, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:0042882 +name: L-arabinose transport +namespace: biological_process +def: "The directed movement of L-arabinose, the levorotatory isomer of arabinose, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015751 ! arabinose transport + +[Term] +id: GO:0042883 +name: cysteine transport +namespace: biological_process +def: "The directed movement of cysteine into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-cysteine transport" NARROW [] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0042884 +name: microcin transport +namespace: biological_process +def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11292337] +subset: gosubset_prok +is_a: GO:0015833 ! peptide transport +is_a: GO:0042891 ! antibiotic transport + +[Term] +id: GO:0042885 +name: microcin B17 transport +namespace: biological_process +def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of, within or between cells." [GOC:jl, PMID:11292337] +subset: gosubset_prok +is_a: GO:0042884 ! microcin transport + +[Term] +id: GO:0042886 +name: amide transport +namespace: biological_process +def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0042887 +name: amide transporter activity +namespace: molecular_function +def: "Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "amine/amide/polyamine channel activity" NARROW [] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0042888 +name: molybdenum ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0042889 +name: 3-phenylpropionic acid transport +namespace: biological_process +def: "The directed movement of 3-phenylpropionic acid into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +synonym: "3-phenylpropionate transport" EXACT [] +synonym: "HCA transport" EXACT [] +synonym: "hydrocinnamic acid transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0042890 +name: 3-phenylpropionic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of 3-phenylpropionic acid from one side of the membrane to the other." [GOC:jl] +synonym: "3-phenylpropionate acid transporter activity" EXACT [] +synonym: "HCA transporter activity" EXACT [] +synonym: "hydrocinnamic acid transporter activity" EXACT [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0042891 +name: antibiotic transport +namespace: biological_process +def: "The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0042892 +name: chloramphenicol transport +namespace: biological_process +def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0042891 ! antibiotic transport + +[Term] +id: GO:0042893 +name: polymyxin transport +namespace: biological_process +def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0042891 ! antibiotic transport + +[Term] +id: GO:0042894 +name: fosmidomycin transport +namespace: biological_process +def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells." [GOC:jl, PMID:12543685] +subset: gosubset_prok +is_a: GO:0042891 ! antibiotic transport + +[Term] +id: GO:0042895 +name: antibiotic transporter activity +namespace: molecular_function +def: "Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0042896 +name: chloramphenicol transporter activity +namespace: molecular_function +def: "Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0042895 ! antibiotic transporter activity + +[Term] +id: GO:0042897 +name: polymyxin transporter activity +namespace: molecular_function +def: "Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0042895 ! antibiotic transporter activity + +[Term] +id: GO:0042898 +name: fosmidomycin transporter activity +namespace: molecular_function +def: "Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells." [GOC:jl, PMID:12543685] +subset: gosubset_prok +is_a: GO:0042895 ! antibiotic transporter activity + +[Term] +id: GO:0042899 +name: arabinose polymer transport +namespace: biological_process +def: "The directed movement of an arabinose polymer, a repeating chain of arabinose monomers, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0015751 ! arabinose transport + +[Term] +id: GO:0042900 +name: arabinose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015146 ! pentose transmembrane transporter activity + +[Term] +id: GO:0042901 +name: arabinose polymer transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an arabinose polymer, a repeating chain of arabinose monomers, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0042902 +name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein +namespace: biological_process +def: "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345] +subset: gosubset_prok +xref: RESID:AA0345 +is_a: GO:0018104 ! peptidoglycan-protein cross-linking +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0042903 +name: tubulin deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0033558 ! protein deacetylase activity + +[Term] +id: GO:0042904 +name: 9-cis-retinoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] +subset: gosubset_prok +synonym: "9-cis-retinoic acid anabolism" EXACT [] +synonym: "9-cis-retinoic acid biosynthesis" EXACT [] +synonym: "9-cis-retinoic acid formation" EXACT [] +synonym: "9-cis-retinoic acid synthesis" EXACT [] +is_a: GO:0035238 ! vitamin A biosynthetic process +is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process + +[Term] +id: GO:0042905 +name: 9-cis-retinoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] +subset: gosubset_prok +synonym: "9-cis-retinoic acid metabolism" EXACT [] +is_a: GO:0042573 ! retinoic acid metabolic process + +[Term] +id: GO:0042906 +name: xanthine transport +namespace: biological_process +def: "The directed movement of xanthine into, out of, within or between cells. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] +is_a: GO:0006863 ! purine transport + +[Term] +id: GO:0042907 +name: xanthine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] +is_a: GO:0005345 ! purine transmembrane transporter activity + +[Term] +id: GO:0042908 +name: xenobiotic transport +namespace: biological_process +def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0042909 +name: acridine transport +namespace: biological_process +def: "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.wikipedia.org/] +subset: gosubset_prok +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0042910 +name: xenobiotic transporter activity +namespace: molecular_function +def: "Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0042911 +name: acridine transporter activity +namespace: molecular_function +def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0042912 +name: colicin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0022885 ! bacteriocin transmembrane transporter activity + +[Term] +id: GO:0042913 +name: group A colicin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417] +subset: gosubset_prok +is_a: GO:0042912 ! colicin transmembrane transporter activity + +[Term] +id: GO:0042914 +name: colicin transport +namespace: biological_process +def: "The directed movement of a colicin into, out of, within or between cells. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0043213 ! bacteriocin transport + +[Term] +id: GO:0042915 +name: group A colicin transport +namespace: biological_process +def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of, within or between cells." [GOC:jl, PMID:9171417] +subset: gosubset_prok +is_a: GO:0042914 ! colicin transport + +[Term] +id: GO:0042916 +name: alkylphosphonate transport +namespace: biological_process +def: "The directed movement of an alkylphosphonate into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0015716 ! phosphonate transport + +[Term] +id: GO:0042917 +name: alkylphosphonate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0015604 ! phosphonate transmembrane transporter activity + +[Term] +id: GO:0042918 +name: alkanesulfonate transport +namespace: biological_process +def: "The directed movement of an alkanesulfonate into, out of, within or between cells. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "alkanesulphonate transport" EXACT [] +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0042919 +name: benzoate transport +namespace: biological_process +def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0042920 +name: 3-hydroxyphenylpropionic acid transport +namespace: biological_process +def: "The directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT [] +synonym: "m-hydroxyphenylpropionic acid transport" EXACT [] +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0042921 +name: glucocorticoid receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah] +synonym: "glucocorticoid receptor signalling pathway" EXACT [] +is_a: GO:0031958 ! corticosteroid receptor signaling pathway + +[Term] +id: GO:0042922 +name: neuromedin U receptor binding +namespace: molecular_function +def: "Interacting selectively with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0042923 +name: neuropeptide binding +namespace: molecular_function +def: "Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0042924 +name: neuromedin U binding +namespace: molecular_function +def: "Interacting selectively and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108] +synonym: "NMU binding" EXACT [] +is_a: GO:0042923 ! neuropeptide binding + +[Term] +id: GO:0042925 +name: benzoate transporter activity +namespace: molecular_function +def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0042926 +name: 3-hydroxyphenylpropionic acid transporter activity +namespace: molecular_function +def: "Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT [] +synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT [] +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0042927 +name: siderophore transporter activity +namespace: molecular_function +def: "Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +synonym: "siderochrome transporter activity" NARROW [] +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0042928 +name: ferrichrome transport +namespace: biological_process +def: "The directed movement of a ferrichrome into, out of, within or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015891 ! siderophore transport + +[Term] +id: GO:0042929 +name: ferrichrome transporter activity +namespace: molecular_function +def: "Enables the directed movement of a ferrichrome into, out of, within or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0042927 ! siderophore transporter activity + +[Term] +id: GO:0042930 +name: enterobactin transport +namespace: biological_process +def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "enterochelin transport" EXACT [] +is_a: GO:0015891 ! siderophore transport + +[Term] +id: GO:0042931 +name: enterobactin transporter activity +namespace: molecular_function +def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "enterochelin transporter activity" EXACT [] +is_a: GO:0042927 ! siderophore transporter activity + +[Term] +id: GO:0042932 +name: chrysobactin transport +namespace: biological_process +def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells." [GOC:jl, PMID:8837459] +subset: gosubset_prok +is_a: GO:0015891 ! siderophore transport + +[Term] +id: GO:0042933 +name: chrysobactin transporter activity +namespace: molecular_function +def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells." [GOC:jl, PMID:8837459] +subset: gosubset_prok +is_a: GO:0042927 ! siderophore transporter activity + +[Term] +id: GO:0042934 +name: achromobactin transporter activity +namespace: molecular_function +def: "Enables the directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042927 ! siderophore transporter activity +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0042935 +name: achromobactin transport +namespace: biological_process +def: "The directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells." [GOC:jl, PMID:10928541] +subset: gosubset_prok +is_a: GO:0015891 ! siderophore transport +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0042936 +name: dipeptide transporter activity +namespace: molecular_function +def: "Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0015198 ! oligopeptide transporter activity + +[Term] +id: GO:0042937 +name: tripeptide transporter activity +namespace: molecular_function +def: "Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0015198 ! oligopeptide transporter activity + +[Term] +id: GO:0042938 +name: dipeptide transport +namespace: biological_process +def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006857 ! oligopeptide transport + +[Term] +id: GO:0042939 +name: tripeptide transport +namespace: biological_process +def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006857 ! oligopeptide transport + +[Term] +id: GO:0042940 +name: D-amino acid transport +namespace: biological_process +def: "The directed movement of the dextrorotatory isomer of an amino acid into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0042941 +name: D-alanine transport +namespace: biological_process +def: "The directed movement of D-alanine, the dextrorotatory isomer of 2-aminopropanoic acid, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0032328 ! alanine transport +is_a: GO:0042940 ! D-amino acid transport + +[Term] +id: GO:0042942 +name: D-serine transport +namespace: biological_process +def: "The directed movement of D-serine, the dextrorotatory isomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0032329 ! serine transport +is_a: GO:0042940 ! D-amino acid transport + +[Term] +id: GO:0042943 +name: D-amino acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the dextrorotatory isomer of amino acids." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "D-amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0042944 +name: D-alanine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-alanine from one side of a membrane to the other. D-alanine is the dextrorotatory isomer of 2-aminopropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "D-alanine transporter activity" BROAD [] +is_a: GO:0022858 ! alanine transmembrane transporter activity +is_a: GO:0042943 ! D-amino acid transmembrane transporter activity + +[Term] +id: GO:0042945 +name: D-serine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-serine from one side of a membrane to the other. D-serine is the dextrorotatory isomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "D-serine permease activity" EXACT [] +synonym: "D-serine transporter activity" BROAD [] +is_a: GO:0022889 ! serine transmembrane transporter activity +is_a: GO:0042943 ! D-amino acid transmembrane transporter activity + +[Term] +id: GO:0042946 +name: glucoside transport +namespace: biological_process +def: "The directed movement of glucosides into, out of, within or between cells. Glucosides are glycosides in which the sugar moiety is a glucose residue." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0042947 +name: glucoside transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar moiety is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0051119 ! sugar transmembrane transporter activity + +[Term] +id: GO:0042948 +name: salicin transport +namespace: biological_process +def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0015759 ! beta-glucoside transport + +[Term] +id: GO:0042949 +name: arbutin transport +namespace: biological_process +def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of, within or between cells." [GOC:jl, http://biotech.icmb.utexas.edu/] +is_a: GO:0015759 ! beta-glucoside transport + +[Term] +id: GO:0042950 +name: salicin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729] +subset: gosubset_prok +is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity + +[Term] +id: GO:0042951 +name: arbutin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729] +is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity + +[Term] +id: GO:0042952 +name: beta-ketoadipate pathway +namespace: biological_process +def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091] +subset: gosubset_prok +synonym: "ortho-cleavage pathway" BROAD [] +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0042953 +name: lipoprotein transport +namespace: biological_process +def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0042954 +name: lipoprotein transporter activity +namespace: molecular_function +def: "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0008565 ! protein transporter activity + +[Term] +id: GO:0042955 +name: dextrin transport +namespace: biological_process +def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of, within or between cells." [GOC:jl, http://www.mercksource.com/] +subset: gosubset_prok +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0042956 +name: maltodextrin transport +namespace: biological_process +def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of, within or between cells." [GOC:jl, http://www.mercksource.com/] +subset: gosubset_prok +is_a: GO:0042955 ! dextrin transport + +[Term] +id: GO:0042957 +name: dextrin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/] +subset: gosubset_prok +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0042958 +name: maltodextrin transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926] +subset: gosubset_prok +is_a: GO:0042957 ! dextrin transmembrane transporter activity + +[Term] +id: GO:0042959 +name: alkanesulfonate transporter activity +namespace: molecular_function +def: "Enables the directed movement of alkanesulfonate into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +synonym: "alkanesulphonate transporter activity" EXACT [] +is_a: GO:0042910 ! xenobiotic transporter activity + +[Term] +id: GO:0042960 +name: antimonite secondary active transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] +subset: gosubset_prok +synonym: "antimonite porter activity" RELATED [] +is_a: GO:0015104 ! antimonite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0042961 +name: antimonite-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:3.6.3.16] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "antimonite ABC transporter" NARROW [] +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances +is_a: GO:0042960 ! antimonite secondary active transmembrane transporter activity + +[Term] +id: GO:0042962 +name: acridine:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876] +subset: gosubset_prok +synonym: "acridine efflux pump activity" RELATED [] +synonym: "acridine:proton antiporter activity" EXACT [] +is_a: GO:0015299 ! solute:hydrogen antiporter activity +is_a: GO:0042911 ! acridine transporter activity + +[Term] +id: GO:0042963 +name: phage assembly +namespace: biological_process +def: "A late phase of bacteriophage replication during which all the components necessary for the formation of a mature virion collect at a particular site in the bacterial cell and the basic structure of the virus particle is formed." [GOC:go_curators] +synonym: "bacteriophage assembly" EXACT [] +is_a: GO:0019068 ! virus assembly + +[Term] +id: GO:0042964 +name: thioredoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators] +subset: gosubset_prok +synonym: "thioredoxin anabolism" EXACT [] +synonym: "thioredoxin biosynthesis" EXACT [] +synonym: "thioredoxin formation" EXACT [] +synonym: "thioredoxin synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0042965 +name: glutaredoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators] +subset: gosubset_prok +synonym: "glutaredoxin anabolism" EXACT [] +synonym: "glutaredoxin biosynthesis" EXACT [] +synonym: "glutaredoxin formation" EXACT [] +synonym: "glutaredoxin synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0042966 +name: biotin carboxyl carrier protein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363] +subset: gosubset_prok +synonym: "BCCP biosynthesis" EXACT [] +synonym: "BCCP biosynthetic process" EXACT [] +synonym: "biotin carboxyl carrier protein anabolism" EXACT [] +synonym: "biotin carboxyl carrier protein biosynthesis" EXACT [] +synonym: "biotin carboxyl carrier protein formation" EXACT [] +synonym: "biotin carboxyl carrier protein synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0042967 +name: acyl-carrier-protein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators] +subset: gosubset_prok +synonym: "ACP biosynthesis" EXACT [] +synonym: "ACP biosynthetic process" EXACT [] +synonym: "acyl carrier protein biosynthesis" EXACT [] +synonym: "acyl carrier protein biosynthetic process" EXACT [] +synonym: "acyl-carrier protein biosynthesis" EXACT [] +synonym: "acyl-carrier-protein anabolism" EXACT [] +synonym: "acyl-carrier-protein biosynthesis" EXACT [] +synonym: "acyl-carrier-protein formation" EXACT [] +synonym: "acyl-carrier-protein synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0042968 +name: homoserine transport +namespace: biological_process +def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of, within or between cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0042969 +name: lactone transport +namespace: biological_process +def: "The directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0042970 +name: homoserine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "homoserine transporter activity" BROAD [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0042971 +name: lactone transporter activity +namespace: molecular_function +def: "Enables the directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0042972 +name: licheninase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds." [EC:3.2.1.73] +subset: gosubset_prok +synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT [] +synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT [] +synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] +synonym: "1,3;1,4-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.73] +synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73] +synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73] +synonym: "endo-beta-1,3-1,4 glucanase activity" EXACT [EC:3.2.1.73] +synonym: "lichenase activity" EXACT [] +synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73] +xref: EC:3.2.1.73 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0042973 +name: glucan endo-1,3-beta-D-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans." [EC:3.2.1.39] +subset: gosubset_prok +synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] +synonym: "(1->3)-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.39] +synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39] +synonym: "1,3-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.39] +synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39] +synonym: "callase activity" EXACT [EC:3.2.1.39] +synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] +synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] +synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39] +synonym: "endo-1,3-beta-glucanase activity" BROAD [] +synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39] +synonym: "kitalase activity" EXACT [EC:3.2.1.39] +synonym: "laminaranase activity" BROAD [] +synonym: "laminarinase activity" BROAD [] +synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39] +xref: EC:3.2.1.39 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0042974 +name: retinoic acid receptor binding +namespace: molecular_function +def: "Interacting selectively with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796] +synonym: "RAR binding" EXACT [] +is_a: GO:0008134 ! transcription factor binding +is_a: GO:0035257 ! nuclear hormone receptor binding + +[Term] +id: GO:0042975 +name: peroxisome proliferator activated receptor binding +namespace: molecular_function +def: "Interacting selectively with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781] +synonym: "PPAR binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0042976 +name: activation of Janus kinase activity +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803] +synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb] +synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT [] +synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" BROAD [] +synonym: "tyrosine phosphorylation of JAK protein" RELATED [] +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0042977 +name: activation of JAK2 kinase activity +namespace: biological_process +def: "The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803] +synonym: "activation of JAK2 protein" EXACT [GOC:dph, GOC:tb] +synonym: "tyrosine phosphorylation of JAK2 protein" RELATED [] +is_a: GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:0042978 +name: ornithine decarboxylase activator activity +namespace: molecular_function +def: "Upregulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] +synonym: "L-ornithine carboxy-lyase activator activity" NARROW [] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0042979 ! ornithine decarboxylase regulator activity + +[Term] +id: GO:0042979 +name: ornithine decarboxylase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0042980 +name: cystic fibrosis transmembrane conductance regulator binding +namespace: molecular_function +def: "Interacting selectively with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl] +synonym: "CFTR binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042981 +name: regulation of apoptosis +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptosis." [GOC:jl] +synonym: "apoptosis regulator activity" RELATED [] +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0006915 ! apoptosis + +[Term] +id: GO:0042982 +name: amyloid precursor protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] +subset: gosubset_prok +synonym: "amyloid precursor protein metabolism" EXACT [] +synonym: "APP metabolic process" EXACT [] +synonym: "APP metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0042983 +name: amyloid precursor protein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] +subset: gosubset_prok +synonym: "amyloid precursor protein anabolism" EXACT [] +synonym: "amyloid precursor protein biosynthesis" EXACT [] +synonym: "amyloid precursor protein formation" EXACT [] +synonym: "amyloid precursor protein synthesis" EXACT [] +synonym: "APP biosynthesis" EXACT [] +synonym: "APP biosynthetic process" EXACT [] +is_a: GO:0009101 ! glycoprotein biosynthetic process +is_a: GO:0042982 ! amyloid precursor protein metabolic process + +[Term] +id: GO:0042984 +name: regulation of amyloid precursor protein biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of amyloid precursor protein anabolism" EXACT [] +synonym: "regulation of amyloid precursor protein biosynthesis" EXACT [] +synonym: "regulation of amyloid precursor protein formation" EXACT [] +synonym: "regulation of amyloid precursor protein synthesis" EXACT [] +synonym: "regulation of APP biosynthesis" EXACT [] +synonym: "regulation of APP biosynthetic process" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process + +[Term] +id: GO:0042985 +name: negative regulation of amyloid precursor protein biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW [] +synonym: "negative regulation of amyloid precursor protein anabolism" EXACT [] +synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT [] +synonym: "negative regulation of amyloid precursor protein formation" EXACT [] +synonym: "negative regulation of amyloid precursor protein synthesis" EXACT [] +synonym: "negative regulation of APP biosynthesis" EXACT [] +synonym: "negative regulation of APP biosynthetic process" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process +relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process + +[Term] +id: GO:0042986 +name: positive regulation of amyloid precursor protein biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of amyloid precursor protein biosynthetic process" NARROW [] +synonym: "positive regulation of amyloid precursor protein anabolism" EXACT [] +synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT [] +synonym: "positive regulation of amyloid precursor protein formation" EXACT [] +synonym: "positive regulation of amyloid precursor protein synthesis" EXACT [] +synonym: "positive regulation of APP biosynthesis" EXACT [] +synonym: "positive regulation of APP biosynthetic process" EXACT [] +synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW [] +synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process +relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process + +[Term] +id: GO:0042987 +name: amyloid precursor protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] +synonym: "amyloid precursor protein breakdown" EXACT [] +synonym: "amyloid precursor protein catabolism" EXACT [] +synonym: "amyloid precursor protein degradation" EXACT [] +synonym: "APP catabolic process" EXACT [] +synonym: "APP catabolism" EXACT [] +is_a: GO:0006516 ! glycoprotein catabolic process +is_a: GO:0042982 ! amyloid precursor protein metabolic process + +[Term] +id: GO:0042988 +name: X11-like protein binding +namespace: molecular_function +def: "Interacting selectively with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348] +synonym: "X11L binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042989 +name: sequestering of actin monomers +namespace: biological_process +def: "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators] +synonym: "actin monomer retention" EXACT [] +synonym: "actin monomer sequestering" EXACT [] +synonym: "actin monomer sequestering activity" RELATED [] +synonym: "actin monomer sequestration" EXACT [] +synonym: "actin monomer storage" EXACT [] +synonym: "retention of actin monomers" EXACT [] +synonym: "sequestration of actin monomers" EXACT [] +synonym: "storage of actin monomers" EXACT [] +is_a: GO:0030837 ! negative regulation of actin filament polymerization +is_a: GO:0045185 ! maintenance of protein location + +[Term] +id: GO:0042990 +name: regulation of transcription factor import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +synonym: "regulation of transcription factor import into cell nucleus" EXACT [] +synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of transcription factor-nucleus import" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +relationship: regulates GO:0042991 ! transcription factor import into nucleus + +[Term] +id: GO:0042991 +name: transcription factor import into nucleus +namespace: biological_process +def: "The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +synonym: "transcription factor import into cell nucleus" EXACT [] +synonym: "transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "transcription factor-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042992 +name: negative regulation of transcription factor import into nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +synonym: "down regulation of transcription factor import into nucleus" EXACT [] +synonym: "down-regulation of transcription factor import into nucleus" EXACT [] +synonym: "downregulation of transcription factor import into nucleus" EXACT [] +synonym: "inhibition of transcription factor import into nucleus" NARROW [] +synonym: "negative regulation of transcription factor import into cell nucleus" EXACT [] +synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of transcription factor-nucleus import" EXACT [] +is_a: GO:0042308 ! negative regulation of protein import into nucleus +is_a: GO:0042990 ! regulation of transcription factor import into nucleus +relationship: negatively_regulates GO:0042991 ! transcription factor import into nucleus + +[Term] +id: GO:0042993 +name: positive regulation of transcription factor import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +synonym: "activation of transcription factor import into nucleus" NARROW [] +synonym: "positive regulation of transcription factor import into cell nucleus" EXACT [] +synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of transcription factor-nucleus import" EXACT [] +synonym: "stimulation of transcription factor import into nucleus" NARROW [] +synonym: "up regulation of transcription factor import into nucleus" EXACT [] +synonym: "up-regulation of transcription factor import into nucleus" EXACT [] +synonym: "upregulation of transcription factor import into nucleus" EXACT [] +is_a: GO:0042307 ! positive regulation of protein import into nucleus +is_a: GO:0042990 ! regulation of transcription factor import into nucleus +relationship: positively_regulates GO:0042991 ! transcription factor import into nucleus + +[Term] +id: GO:0042994 +name: cytoplasmic sequestering of transcription factor +namespace: biological_process +def: "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] +synonym: "cytoplasmic retention of transcription factor" EXACT [] +synonym: "cytoplasmic sequestration of transcription factor" EXACT [] +synonym: "cytoplasmic storage of transcription factor" EXACT [] +synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] +synonym: "retention of transcription factor in cytoplasm" EXACT [] +synonym: "sequestering of transcription factor in cytoplasm" EXACT [] +synonym: "sequestration of transcription factor in cytoplasm" EXACT [] +synonym: "storage of transcription factor in cytoplasm" EXACT [] +synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] +is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus +is_a: GO:0051220 ! cytoplasmic sequestering of protein + +[Term] +id: GO:0042995 +name: cell projection +namespace: cellular_component +def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0042996 +name: regulation of Golgi to plasma membrane protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] +is_a: GO:0033157 ! regulation of intracellular protein transport +relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0042997 +name: negative regulation of Golgi to plasma membrane protein transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] +synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051224 ! negative regulation of protein transport +relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0042998 +name: positive regulation of Golgi to plasma membrane protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] +synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] +synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] +synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051222 ! positive regulation of protein transport +relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0042999 +name: regulation of Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport +relationship: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport + +[Term] +id: GO:0043000 +name: Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT [] +is_a: GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0043001 +name: Golgi to plasma membrane protein transport +namespace: biological_process +def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0006893 ! Golgi to plasma membrane transport + +[Term] +id: GO:0043002 +name: negative regulation of Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW [] +is_a: GO:0042997 ! negative regulation of Golgi to plasma membrane protein transport +is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport +relationship: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport + +[Term] +id: GO:0043003 +name: positive regulation of Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW [] +synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW [] +synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +is_a: GO:0042998 ! positive regulation of Golgi to plasma membrane protein transport +is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport +relationship: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport + +[Term] +id: GO:0043004 +name: cytoplasmic sequestering of CFTR protein +namespace: biological_process +def: "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl] +synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] +synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT [] +synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT [] +synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] +synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] +synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] +synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] +synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] +synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] +is_a: GO:0043002 ! negative regulation of Golgi to plasma membrane CFTR protein transport +is_a: GO:0051220 ! cytoplasmic sequestering of protein + +[Term] +id: GO:0043005 +name: neuron projection +namespace: cellular_component +def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] +subset: goslim_pir +synonym: "neurite" NARROW [] +synonym: "neuronal cell projection" EXACT [] +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0043006 +name: calcium-dependent phospholipase A2 activation +namespace: biological_process +def: "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:jl] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0032431 ! activation of phospholipase A2 + +[Term] +id: GO:0043007 +name: maintenance of rDNA +namespace: biological_process +def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010] +synonym: "rDNA maintenance" EXACT [] +synonym: "ribosomal DNA maintenance" EXACT [] +is_a: GO:0043570 ! maintenance of DNA repeat elements + +[Term] +id: GO:0043008 +name: ATP-dependent protein binding +namespace: molecular_function +def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043009 +name: chordate embryonic development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] +synonym: "embryonic development (sensu Vertebrata)" EXACT [] +is_a: GO:0009792 ! embryonic development ending in birth or egg hatching + +[Term] +id: GO:0043010 +name: camera-type eye development +namespace: biological_process +alt_id: GO:0001747 +alt_id: GO:0031075 +def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] +synonym: "eye development (sensu Actinopterygii)" EXACT [] +synonym: "eye development (sensu Mammalia)" EXACT [] +synonym: "eye development (sensu Vertebrata)" EXACT [] +is_a: GO:0001654 ! eye development + +[Term] +id: GO:0043011 +name: myeloid dendritic cell differentiation +namespace: biological_process +def: "The process by which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [GOC:jl, http://cancerweb.ncl.ac.uk, http://en.wikipedia.org/wiki/ "Wikipedia"] +synonym: "Langerhans cell differentiation" EXACT [] +is_a: GO:0001773 ! myeloid dendritic cell activation +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0043012 +name: regulation of fusion of sperm to egg plasma membrane +namespace: biological_process +def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +synonym: "regulation of sperm-oocyte fusion" NARROW [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane + +[Term] +id: GO:0043013 +name: negative regulation of fusion of sperm to egg plasma membrane +namespace: biological_process +def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT [] +synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT [] +synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT [] +synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW [] +synonym: "inhibition of sperm-oocyte fusion" NARROW [] +synonym: "negative regulation of sperm-oocyte fusion" NARROW [] +is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane + +[Term] +id: GO:0043014 +name: alpha-tubulin binding +namespace: molecular_function +def: "Interacting selectively with the microtubule constituent protein alpha-tubulin." [GOC:jl] +synonym: "alpha tubulin binding" EXACT [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0043015 +name: gamma-tubulin binding +namespace: molecular_function +def: "Interacting selectively with the microtubule constituent protein gamma-tubulin." [GOC:jl] +synonym: "gamma tubulin binding" EXACT [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0043016 +name: regulation of lymphotoxin A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] +synonym: "regulation of LTA biosynthesis" EXACT [] +synonym: "regulation of LTA biosynthetic process" EXACT [] +synonym: "regulation of lymphotoxin A anabolism" EXACT [] +synonym: "regulation of lymphotoxin A biosynthesis" EXACT [] +synonym: "regulation of lymphotoxin A formation" EXACT [] +synonym: "regulation of lymphotoxin A synthesis" EXACT [] +synonym: "regulation of lymphotoxin-alpha biosynthesis" EXACT [] +synonym: "regulation of lymphotoxin-alpha biosynthetic process" EXACT [] +synonym: "regulation of TNF-B biosynthesis" EXACT [] +synonym: "regulation of TNF-B biosynthetic process" EXACT [] +synonym: "regulation of TNF-beta biosynthesis" EXACT [] +synonym: "regulation of TNF-beta biosynthetic process" EXACT [] +synonym: "regulation of tumor necrosis factor-beta biosynthesis" EXACT [] +synonym: "regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] +is_a: GO:0032681 ! regulation of lymphotoxin A production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042109 ! lymphotoxin A biosynthetic process + +[Term] +id: GO:0043017 +name: positive regulation of lymphotoxin A biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] +synonym: "activation of lymphotoxin A biosynthetic process" NARROW [] +synonym: "positive regulation of LTA biosynthesis" EXACT [] +synonym: "positive regulation of LTA biosynthetic process" EXACT [] +synonym: "positive regulation of lymphotoxin A anabolism" EXACT [] +synonym: "positive regulation of lymphotoxin A biosynthesis" EXACT [] +synonym: "positive regulation of lymphotoxin A formation" EXACT [] +synonym: "positive regulation of lymphotoxin A synthesis" EXACT [] +synonym: "positive regulation of lymphotoxin-alpha biosynthesis" EXACT [] +synonym: "positive regulation of lymphotoxin-alpha biosynthetic process" EXACT [] +synonym: "positive regulation of TNF-B biosynthesis" EXACT [] +synonym: "positive regulation of TNF-B biosynthetic process" EXACT [] +synonym: "positive regulation of TNF-beta biosynthesis" EXACT [] +synonym: "positive regulation of TNF-beta biosynthetic process" EXACT [] +synonym: "positive regulation of tumor necrosis factor-beta biosynthesis" EXACT [] +synonym: "positive regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] +synonym: "stimulation of lymphotoxin A biosynthetic process" NARROW [] +synonym: "up regulation of lymphotoxin A biosynthetic process" EXACT [] +synonym: "up-regulation of lymphotoxin A biosynthetic process" EXACT [] +synonym: "upregulation of lymphotoxin A biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process +relationship: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process + +[Term] +id: GO:0043018 +name: negative regulation of lymphotoxin A biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] +synonym: "down regulation of lymphotoxin A biosynthetic process" EXACT [] +synonym: "down-regulation of lymphotoxin A biosynthetic process" EXACT [] +synonym: "downregulation of lymphotoxin A biosynthetic process" EXACT [] +synonym: "inhibition of lymphotoxin A biosynthetic process" NARROW [] +synonym: "negative regulation of LTA biosynthesis" EXACT [] +synonym: "negative regulation of LTA biosynthetic process" EXACT [] +synonym: "negative regulation of lymphotoxin A anabolism" EXACT [] +synonym: "negative regulation of lymphotoxin A biosynthesis" EXACT [] +synonym: "negative regulation of lymphotoxin A formation" EXACT [] +synonym: "negative regulation of lymphotoxin A synthesis" EXACT [] +synonym: "negative regulation of lymphotoxin-alpha biosynthesis" EXACT [] +synonym: "negative regulation of lymphotoxin-alpha biosynthetic process" EXACT [] +synonym: "negative regulation of TNF-B biosynthesis" EXACT [] +synonym: "negative regulation of TNF-B biosynthetic process" EXACT [] +synonym: "negative regulation of TNF-beta biosynthesis" EXACT [] +synonym: "negative regulation of TNF-beta biosynthetic process" EXACT [] +synonym: "negative regulation of tumor necrosis factor-beta biosynthesis" EXACT [] +synonym: "negative regulation of tumor necrosis factor-beta biosynthetic process" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process +relationship: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process + +[Term] +id: GO:0043020 +name: NADPH oxidase complex +namespace: cellular_component +def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767] +synonym: "flavocytochrome b558" NARROW [] +synonym: "respiratory-burst oxidase" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0043021 +name: ribonucleoprotein binding +namespace: molecular_function +def: "Interacting selectively with any complex of RNA and protein." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +synonym: "RNP binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043022 +name: ribosome binding +namespace: molecular_function +alt_id: GO:0030376 +def: "Interacting selectively with any part of a ribosome." [GOC:go_curators] +subset: gosubset_prok +synonym: "ribosome receptor activity" NARROW [] +is_a: GO:0043021 ! ribonucleoprotein binding + +[Term] +id: GO:0043023 +name: ribosomal large subunit binding +namespace: molecular_function +def: "Interacting selectively with any part of the larger ribosomal subunit." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0043021 ! ribonucleoprotein binding + +[Term] +id: GO:0043024 +name: ribosomal small subunit binding +namespace: molecular_function +def: "Interacting selectively with any part of the small ribosomal subunit." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0043021 ! ribonucleoprotein binding + +[Term] +id: GO:0043025 +name: cell soma +namespace: cellular_component +def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] +comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. +subset: goslim_pir +synonym: "cell body" EXACT [] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0043027 +name: caspase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] +is_a: GO:0004866 ! endopeptidase inhibitor activity +is_a: GO:0043028 ! caspase regulator activity + +[Term] +id: GO:0043028 +name: caspase regulator activity +namespace: molecular_function +def: "Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0043029 +name: T cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. +synonym: "T lymphocyte homeostasis" EXACT [] +synonym: "T-cell homeostasis" EXACT [] +synonym: "T-lymphocyte homeostasis" EXACT [] +is_a: GO:0002260 ! lymphocyte homeostasis + +[Term] +id: GO:0043030 +name: regulation of macrophage activation +namespace: biological_process +def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0042116 ! macrophage activation + +[Term] +id: GO:0043031 +name: negative regulation of macrophage activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] +synonym: "down regulation of macrophage activation" EXACT [] +synonym: "down-regulation of macrophage activation" EXACT [] +synonym: "downregulation of macrophage activation" EXACT [] +synonym: "inhibition of macrophage activation" NARROW [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0043030 ! regulation of macrophage activation +relationship: negatively_regulates GO:0042116 ! macrophage activation + +[Term] +id: GO:0043032 +name: positive regulation of macrophage activation +namespace: biological_process +def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] +synonym: "activation of macrophage activation" NARROW [] +synonym: "stimulation of macrophage activation" NARROW [] +synonym: "up regulation of macrophage activation" EXACT [] +synonym: "up-regulation of macrophage activation" EXACT [] +synonym: "upregulation of macrophage activation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0043030 ! regulation of macrophage activation +relationship: positively_regulates GO:0042116 ! macrophage activation + +[Term] +id: GO:0043033 +name: isoamylase complex +namespace: cellular_component +def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591] +subset: goslim_pir +subset: gosubset_prok +synonym: "debranching enzyme complex" BROAD [] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0043034 +name: costamere +namespace: cellular_component +def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:6405378] +is_a: GO:0044449 ! contractile fiber part +relationship: part_of GO:0030016 ! myofibril + +[Term] +id: GO:0043035 +name: chromatin insulator sequence binding +namespace: molecular_function +def: "Interacting selectively and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795] +is_a: GO:0031490 ! chromatin DNA binding + +[Term] +id: GO:0043036 +name: starch grain +namespace: cellular_component +def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] +synonym: "starch granule" EXACT [] +is_a: GO:0044435 ! plastid part + +[Term] +id: GO:0043038 +name: amino acid activation +namespace: biological_process +def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0043039 +name: tRNA aminoacylation +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma] +subset: gosubset_prok +synonym: "tRNA charging" EXACT [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0043038 ! amino acid activation + +[Term] +id: GO:0043040 +name: tRNA aminoacylation for nonribosomal peptide biosynthetic process +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl] +subset: gosubset_prok +synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT [] +synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT [] +synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT [] +synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT [] +is_a: GO:0043039 ! tRNA aminoacylation +is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process + +[Term] +id: GO:0043041 +name: amino acid activation for nonribosomal peptide biosynthetic process +namespace: biological_process +def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl] +subset: gosubset_prok +synonym: "nonribosomal amino acid activation" RELATED [] +is_a: GO:0043038 ! amino acid activation +relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process + +[Term] +id: GO:0043042 +name: amino acid adenylylation by nonribosomal peptide synthase +namespace: biological_process +def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910] +subset: gosubset_prok +synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT [] +synonym: "amino acid adenylation by NRPS" EXACT [] +is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process + +[Term] +id: GO:0043043 +name: peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +synonym: "peptide anabolism" EXACT [] +synonym: "peptide biosynthesis" EXACT [] +synonym: "peptide formation" EXACT [] +synonym: "peptide synthesis" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0043044 +name: ATP-dependent chromatin remodeling +namespace: biological_process +def: "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764] +synonym: "ATP-dependent chromatin remodelling" EXACT [] +is_a: GO:0006338 ! chromatin remodeling + +[Term] +id: GO:0043045 +name: DNA methylation during embryonic development +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 of cytosine during embryogenesis, when DNA methylation patterns are established." [GOC:go_curators, PMID:12138111] +synonym: "de novo DNA methylation" NARROW [] +is_a: GO:0006306 ! DNA methylation +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0043046 +name: DNA methylation during gametogenesis +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established." [GOC:go_curators, PMID:12138111] +synonym: "de novo DNA methylation" NARROW [] +is_a: GO:0006306 ! DNA methylation +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0043047 +name: single-stranded telomeric DNA binding +namespace: molecular_function +def: "Interacting selectively with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] +is_a: GO:0003697 ! single-stranded DNA binding +is_a: GO:0042162 ! telomeric DNA binding + +[Term] +id: GO:0043048 +name: dolichyl monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl] +subset: gosubset_prok +synonym: "dolichyl monophosphate anabolism" EXACT [] +synonym: "dolichyl monophosphate biosynthesis" EXACT [] +synonym: "dolichyl monophosphate formation" EXACT [] +synonym: "dolichyl monophosphate synthesis" EXACT [] +is_a: GO:0019408 ! dolichol biosynthetic process + +[Term] +id: GO:0043049 +name: otic placode formation +namespace: biological_process +def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0030916 ! otic vesicle formation + +[Term] +id: GO:0043050 +name: pharyngeal pumping +namespace: biological_process +def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052] +synonym: "pumping behavior" RELATED [] +is_a: GO:0042755 ! eating behavior + +[Term] +id: GO:0043051 +name: regulation of pharyngeal pumping +namespace: biological_process +def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052] +is_a: GO:0060259 ! regulation of feeding behavior +relationship: regulates GO:0043050 ! pharyngeal pumping + +[Term] +id: GO:0043052 +name: thermotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] +synonym: "taxis in response to temperature stimulus" EXACT [] +is_a: GO:0009266 ! response to temperature stimulus +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0043053 +name: dauer entry +namespace: biological_process +def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:10077613] +synonym: "nematode entry into dormancy" EXACT [] +is_a: GO:0022611 ! dormancy process +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:0043054 +name: dauer exit +namespace: biological_process +def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986] +synonym: "exit from nematode dormancy" EXACT [] +is_a: GO:0022611 ! dormancy process +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:0043055 +name: maintenance of dauer +namespace: biological_process +def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740] +synonym: "maintenance of dormancy in the nematode" EXACT [] +is_a: GO:0022611 ! dormancy process +is_a: GO:0060249 ! anatomical structure homeostasis +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:0043056 +name: forward locomotion +namespace: biological_process +def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators] +is_a: GO:0033058 ! directional locomotion + +[Term] +id: GO:0043057 +name: backward locomotion +namespace: biological_process +def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators] +is_a: GO:0033058 ! directional locomotion + +[Term] +id: GO:0043058 +name: regulation of backward locomotion +namespace: biological_process +def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators] +is_a: GO:0040012 ! regulation of locomotion +relationship: regulates GO:0043057 ! backward locomotion + +[Term] +id: GO:0043059 +name: regulation of forward locomotion +namespace: biological_process +def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators] +is_a: GO:0040012 ! regulation of locomotion +relationship: regulates GO:0043056 ! forward locomotion + +[Term] +id: GO:0043060 +name: meiotic metaphase I plate congression +namespace: biological_process +def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666] +is_a: GO:0051311 ! meiotic metaphase plate congression +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0043061 +name: meiotic metaphase II plate congression +namespace: biological_process +def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666] +is_a: GO:0051311 ! meiotic metaphase plate congression +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0043062 +name: extracellular structure organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "extracellular structure organisation and biogenesis" EXACT [] +synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043063 +name: intercellular bridge organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jic] +synonym: "intercellular bridge organisation and biogenesis" EXACT [] +synonym: "intercellular bridge organization and biogenesis" EXACT [] +is_a: GO:0043062 ! extracellular structure organization + +[Term] +id: GO:0043064 +name: flagellum organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:jl, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +synonym: "flagellum organisation and biogenesis" EXACT [] +synonym: "flagellum organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0043065 +name: positive regulation of apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptosis." [GOC:jl] +synonym: "activation of apoptosis" NARROW [] +synonym: "stimulation of apoptosis" NARROW [] +synonym: "up regulation of apoptosis" EXACT [] +synonym: "up-regulation of apoptosis" EXACT [] +synonym: "upregulation of apoptosis" EXACT [] +is_a: GO:0042981 ! regulation of apoptosis +is_a: GO:0043068 ! positive regulation of programmed cell death +relationship: positively_regulates GO:0006915 ! apoptosis + +[Term] +id: GO:0043066 +name: negative regulation of apoptosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis." [GOC:jl] +synonym: "down regulation of apoptosis" EXACT [] +synonym: "down-regulation of apoptosis" EXACT [] +synonym: "downregulation of apoptosis" EXACT [] +synonym: "inhibition of apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptosis +is_a: GO:0043069 ! negative regulation of programmed cell death +relationship: negatively_regulates GO:0006915 ! apoptosis + +[Term] +id: GO:0043067 +name: regulation of programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0043068 +name: positive regulation of programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] +synonym: "activation of programmed cell death" NARROW [] +synonym: "stimulation of programmed cell death" NARROW [] +synonym: "up regulation of programmed cell death" EXACT [] +synonym: "up-regulation of programmed cell death" EXACT [] +synonym: "upregulation of programmed cell death" EXACT [] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0043069 +name: negative regulation of programmed cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] +synonym: "down regulation of programmed cell death" EXACT [] +synonym: "down-regulation of programmed cell death" EXACT [] +synonym: "downregulation of programmed cell death" EXACT [] +synonym: "inhibition of programmed cell death" NARROW [] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0043070 +name: regulation of non-apoptotic programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-apoptotic programmed cell death, cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis." [GOC:go_curators] +synonym: "regulation of nonapoptotic programmed cell death" EXACT [] +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0016244 ! non-apoptotic programmed cell death + +[Term] +id: GO:0043071 +name: positive regulation of non-apoptotic programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of non-apoptotic programmed cell death, cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis." [GOC:go_curators] +synonym: "activation of non-apoptotic programmed cell death" NARROW [] +synonym: "positive regulation of nonapoptotic programmed cell death" EXACT [] +synonym: "stimulation of non-apoptotic programmed cell death" NARROW [] +synonym: "up regulation of non-apoptotic programmed cell death" EXACT [] +synonym: "up-regulation of non-apoptotic programmed cell death" EXACT [] +synonym: "upregulation of non-apoptotic programmed cell death" EXACT [] +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0043070 ! regulation of non-apoptotic programmed cell death +relationship: positively_regulates GO:0016244 ! non-apoptotic programmed cell death + +[Term] +id: GO:0043072 +name: negative regulation of non-apoptotic programmed cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-apoptotic programmed cell death, cell death resulting from activation of endogenous cellular processes, by a mechanism other than apoptosis." [GOC:go_curators] +synonym: "down regulation of non-apoptotic programmed cell death" EXACT [] +synonym: "down-regulation of non-apoptotic programmed cell death" EXACT [] +synonym: "downregulation of non-apoptotic programmed cell death" EXACT [] +synonym: "inhibition of non-apoptotic programmed cell death" NARROW [] +synonym: "negative regulation of nonapoptotic programmed cell death" EXACT [] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0043070 ! regulation of non-apoptotic programmed cell death +relationship: negatively_regulates GO:0016244 ! non-apoptotic programmed cell death + +[Term] +id: GO:0043073 +name: germ cell nucleus +namespace: cellular_component +def: "The nucleus of a germ cell, a cell specialized to produce haploid gametes, and its descendents." [GOC:go_curators, http://cancerweb.ncl.ac.uk] +synonym: "germ-cell nucleus" EXACT [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0043075 +name: sperm cell nucleus (sensu Magnoliophyta) +namespace: cellular_component +def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl] +comment: This term was made obsolete because the definition was incorrect. +synonym: "pollen germ cell nucleus" EXACT [] +synonym: "pollen germ-cell nucleus" EXACT [] +is_obsolete: true +consider: GO:0048555 + +[Term] +id: GO:0043076 +name: megasporocyte nucleus +namespace: cellular_component +def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153] +synonym: "megaspore mother cell nucleus" EXACT [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0043077 +name: initiation of acetate catabolic process +namespace: biological_process +def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl] +subset: gosubset_prok +synonym: "initiation of acetate breakdown" EXACT [] +synonym: "initiation of acetate catabolism" EXACT [] +synonym: "initiation of acetate degradation" EXACT [] +is_a: GO:0045754 ! positive regulation of acetate catabolic process + +[Term] +id: GO:0043078 +name: polar nucleus +namespace: cellular_component +def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153] +is_a: GO:0043076 ! megasporocyte nucleus + +[Term] +id: GO:0043079 +name: antipodal cell nucleus +namespace: cellular_component +def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [GOC:jl, http://cancerweb.ncl.ac.uk] +is_a: GO:0043076 ! megasporocyte nucleus + +[Term] +id: GO:0043082 +name: megagametophyte egg cell nucleus +namespace: cellular_component +def: "The nucleus of a plant egg cell, the female gamete, at the micropylar end of the embryo and its descendents." [GOC:jl, GOC:mtg_sensu] +synonym: "egg cell nucleus (sensu Viridiplantae)" EXACT [] +is_a: GO:0043076 ! megasporocyte nucleus + +[Term] +id: GO:0043083 +name: synaptic cleft +namespace: cellular_component +def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044456 ! synapse part + +[Term] +id: GO:0043084 +name: penile erection +namespace: biological_process +def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, http://en.wikipedia.org/wiki/ "Wikipedia"] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007620 ! copulation + +[Term] +id: GO:0043085 +name: positive regulation of catalytic activity +namespace: biological_process +def: "Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb] +subset: gosubset_prok +synonym: "activation of enzyme activity" NARROW [] +synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] +synonym: "stimulation of enzyme activity" NARROW [] +synonym: "up regulation of enzyme activity" EXACT [] +synonym: "up-regulation of enzyme activity" EXACT [] +synonym: "upregulation of enzyme activity" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0043086 +name: negative regulation of catalytic activity +namespace: biological_process +def: "Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb] +subset: gosubset_prok +synonym: "down regulation of enzyme activity" EXACT [] +synonym: "down-regulation of enzyme activity" EXACT [] +synonym: "downregulation of enzyme activity" EXACT [] +synonym: "inhibition of enzyme activity" NARROW [] +synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0043087 +name: regulation of GTPase activity +namespace: biological_process +def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl] +subset: gosubset_prok +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0043088 +name: regulation of Cdc42 GTPase activity +namespace: biological_process +def: "Any process that modulates the activity of the GTPase Cdc42." [GOC:jl] +is_a: GO:0032319 ! regulation of Rho GTPase activity +relationship: part_of GO:0032489 ! regulation of Cdc42 protein signal transduction + +[Term] +id: GO:0043089 +name: positive regulation of Cdc42 GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the GTPase Cdc42." [GOC:jl] +synonym: "stimulation of Cdc42 GTPase activity" NARROW [] +synonym: "up regulation of Cdc42 GTPase activity" EXACT [] +synonym: "up-regulation of Cdc42 GTPase activity" EXACT [] +synonym: "upregulation of Cdc42 GTPase activity" EXACT [] +is_a: GO:0032321 ! positive regulation of Rho GTPase activity +is_a: GO:0043088 ! regulation of Cdc42 GTPase activity + +[Term] +id: GO:0043090 +name: amino acid import +namespace: biological_process +def: "The directed movement of amino acids into a cell or organelle." [GOC:jl] +subset: gosubset_prok +synonym: "amino acid uptake" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0043091 +name: L-arginine import +namespace: biological_process +def: "The directed movement of L-arginine, the levorotatory isomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:jl] +synonym: "L-arginine uptake" EXACT [] +is_a: GO:0015809 ! arginine transport +is_a: GO:0043092 ! L-amino acid import + +[Term] +id: GO:0043092 +name: L-amino acid import +namespace: biological_process +def: "The directed movement of levorotatory isomer amino acids into a cell or organelle." [GOC:jl] +subset: gosubset_prok +synonym: "L-amino acid uptake" EXACT [] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0043093 +name: binary fission +namespace: biological_process +def: "A process in which two similarly sized and shaped cells are formed by the division of one cell, the process by which most bacteria reproduce." [ISBN:0815108893] +subset: gosubset_prok +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0032505 ! reproduction of a single-celled organism + +[Term] +id: GO:0043094 +name: cellular metabolic compound salvage +namespace: biological_process +def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0043095 +name: regulation of GTP cyclohydrolase I activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] +subset: gosubset_prok +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0043096 +name: purine base salvage +namespace: biological_process +def: "Any process that generates purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006144 ! purine base metabolic process +is_a: GO:0043101 ! purine salvage + +[Term] +id: GO:0043097 +name: pyrimidine nucleoside salvage +namespace: biological_process +def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0008655 ! pyrimidine salvage +is_a: GO:0043174 ! nucleoside salvage + +[Term] +id: GO:0043098 +name: purine deoxyribonucleoside salvage +namespace: biological_process +def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043101 ! purine salvage +is_a: GO:0043174 ! nucleoside salvage +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0043099 +name: pyrimidine deoxyribonucleoside salvage +namespace: biological_process +def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043097 ! pyrimidine nucleoside salvage +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0043100 +name: pyrimidine base salvage +namespace: biological_process +def: "Any process that generates pyrimidine bases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0008655 ! pyrimidine salvage + +[Term] +id: GO:0043101 +name: purine salvage +namespace: biological_process +def: "Any process that generates a purine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043102 +name: amino acid salvage +namespace: biological_process +def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006520 ! amino acid metabolic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043103 +name: hypoxanthine salvage +namespace: biological_process +def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW [] +synonym: "guanine, xanthine and their nucleoside salvage" NARROW [] +is_a: GO:0043096 ! purine base salvage +is_a: GO:0046100 ! hypoxanthine metabolic process + +[Term] +id: GO:0043104 +name: positive regulation of GTP cyclohydrolase I activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] +subset: gosubset_prok +synonym: "activation of GTP cyclohydrolase I activity" NARROW [] +synonym: "stimulation of GTP cyclohydrolase I activity" NARROW [] +synonym: "up regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "upregulation of GTP cyclohydrolase I activity" EXACT [] +is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0043105 +name: negative regulation of GTP cyclohydrolase I activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] +subset: gosubset_prok +synonym: "down regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "downregulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "inhibition of GTP cyclohydrolase I activity" NARROW [] +is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0043106 +name: GTP cyclohydrolase I binding +namespace: molecular_function +def: "Interacting selectively with the enzyme GTP cyclohydrolase I." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0043107 +name: type IV pilus-dependent motility +namespace: biological_process +def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238] +subset: gosubset_prok +synonym: "social gliding motility" NARROW [] +synonym: "TFP-dependent motility" EXACT [] +synonym: "TFP-dependent movement" EXACT [] +synonym: "twitching motility" NARROW [] +synonym: "type 4 pilus-dependent motility" EXACT [] +synonym: "type four pilus-dependent motility" EXACT [] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0043108 +name: pilus retraction +namespace: biological_process +def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0043711 ! pilus organization + +[Term] +id: GO:0043110 +name: rDNA spacer replication fork barrier binding +namespace: molecular_function +def: "Interacting selectively with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529] +synonym: "RFB binding" EXACT [] +synonym: "RTS1 barrier binding" EXACT [] +synonym: "RTS1 element binding" EXACT [] +is_a: GO:0000182 ! rDNA binding +is_a: GO:0031634 ! replication fork barrier binding + +[Term] +id: GO:0043111 +name: replication fork arrest +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork." [GOC:jl, PMID:14645529] +subset: gosubset_prok +synonym: "replication fork blocking" EXACT [] +synonym: "replication fork stalling" EXACT [] +is_a: GO:0008156 ! negative regulation of DNA replication + +[Term] +id: GO:0043112 +name: receptor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl] +subset: gosubset_prok +synonym: "receptor metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0043113 +name: receptor clustering +namespace: biological_process +def: "Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf] +is_a: GO:0043112 ! receptor metabolic process +relationship: part_of GO:0007172 ! signal complex assembly + +[Term] +id: GO:0043114 +name: regulation of vascular permeability +namespace: biological_process +def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0043115 +name: precorrin-2 dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: precorrin-2 (dihydrosirohydrochlorin) + NAD+ = sirohydrochlorin + NADH + H+." [EC:1.3.1.76] +subset: gosubset_prok +synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT [] +synonym: "CysG" RELATED [EC:1.3.1.76] +synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT [] +synonym: "Met8p" RELATED [EC:1.3.1.76] +synonym: "precorrin-2 oxidase activity" EXACT [EC:1.3.1.76] +synonym: "precorrin-2:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.76] +synonym: "SirC" RELATED [EC:1.3.1.76] +synonym: "siroheme synthase activity" BROAD [] +xref: EC:1.3.1.76 +xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043116 +name: negative regulation of vascular permeability +namespace: biological_process +def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl] +synonym: "down regulation of vascular permeability" EXACT [] +synonym: "down-regulation of vascular permeability" EXACT [] +synonym: "downregulation of vascular permeability" EXACT [] +synonym: "inhibition of vascular permeability" NARROW [] +is_a: GO:0043114 ! regulation of vascular permeability + +[Term] +id: GO:0043117 +name: positive regulation of vascular permeability +namespace: biological_process +def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl] +synonym: "activation of vascular permeability" NARROW [] +synonym: "stimulation of vascular permeability" NARROW [] +synonym: "up regulation of vascular permeability" EXACT [] +synonym: "up-regulation of vascular permeability" EXACT [] +synonym: "upregulation of vascular permeability" EXACT [] +is_a: GO:0043114 ! regulation of vascular permeability + +[Term] +id: GO:0043120 +name: tumor necrosis factor binding +namespace: molecular_function +def: "Interacting selectively with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0043121 +name: neurotrophin binding +namespace: molecular_function +def: "Interacting selectively with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:jl, http://www.mercksource.com/] +synonym: "neurotrophin TRK receptor activity" RELATED [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0043122 +name: regulation of I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl, PMID:12773372] +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0043123 +name: positive regulation of I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl] +synonym: "activation of I-kappaB kinase/NF-kappaB cascade" NARROW [] +synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW [] +synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] +is_a: GO:0010740 ! positive regulation of protein kinase cascade +is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade +relationship: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0043124 +name: negative regulation of I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl] +synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" NARROW [] +is_a: GO:0010741 ! negative regulation of protein kinase cascade +is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade +relationship: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0043125 +name: ErbB-3 class receptor binding +namespace: molecular_function +def: "Interacting selectively with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl] +synonym: "HER3 receptor binding" EXACT [] +synonym: "Neu/ErbB-2 receptor activity" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0043126 +name: regulation of 1-phosphatidylinositol 4-kinase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] +subset: gosubset_prok +synonym: "regulation of PI4K activity" EXACT [] +is_a: GO:0043550 ! regulation of lipid kinase activity + +[Term] +id: GO:0043127 +name: negative regulation of 1-phosphatidylinositol 4-kinase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] +subset: gosubset_prok +synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW [] +synonym: "negative regulation of PI4K activity" EXACT [] +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity + +[Term] +id: GO:0043128 +name: positive regulation of 1-phosphatidylinositol 4-kinase activity +namespace: biological_process +def: "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl] +subset: gosubset_prok +synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW [] +synonym: "positive regulation of PI4K activity" EXACT [] +synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW [] +synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity + +[Term] +id: GO:0043129 +name: surfactant homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an equilibrium of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757] +is_a: GO:0048875 ! chemical homeostasis within a tissue + +[Term] +id: GO:0043130 +name: ubiquitin binding +namespace: molecular_function +def: "Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] +is_a: GO:0032182 ! small conjugating protein binding + +[Term] +id: GO:0043131 +name: enucleation +namespace: biological_process +def: "The process by which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hgd] +is_a: GO:0022411 ! cellular component disassembly +relationship: part_of GO:0043354 ! enucleate erythrocyte maturation + +[Term] +id: GO:0043132 +name: NAD transport +namespace: biological_process +def: "The directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl] +synonym: "NAD (oxidized) transport" EXACT [] +synonym: "NAD (reduced) transport" EXACT [] +synonym: "NADH transport" EXACT [] +synonym: "nicotinamide adenine dinucleotide transport" EXACT [] +synonym: "oxidized NAD transport" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT [] +synonym: "reduced NAD transport" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT [] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0043133 +name: hindgut contraction +namespace: biological_process +def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step. The chemo-mechanical energy conversion step is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk] +is_a: GO:0006939 ! smooth muscle contraction +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0043134 +name: regulation of hindgut contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, http://cancerweb.ncl.ac.uk] +is_a: GO:0006940 ! regulation of smooth muscle contraction +relationship: regulates GO:0043133 ! hindgut contraction + +[Term] +id: GO:0043135 +name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the diphosphate bond in 5-phosphoribosyl 1-pyrophosphate." [GOC:jl, http://cancerweb.ncl.ac.uk, PMID:12370170] +synonym: "PRPP pyrophosphatase activity" EXACT [] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0043136 +name: glycerol-3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043137 +name: DNA replication, removal of RNA primer +namespace: biological_process +def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238] +subset: gosubset_prok +synonym: "Okazaki initiator RNA removal" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0006401 ! RNA catabolic process +relationship: part_of GO:0033567 ! DNA replication, Okazaki fragment processing + +[Term] +id: GO:0043138 +name: 3'-5' DNA helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] +synonym: "3' to 5' DNA helicase activity" EXACT [] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0043139 +name: 5'-3' DNA helicase activity +namespace: molecular_function +def: "Catalysis of the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] +synonym: "5' to 3' DNA helicase activity" EXACT [] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0043140 +name: ATP-dependent 3'-5' DNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] +is_a: GO:0004003 ! ATP-dependent DNA helicase activity +is_a: GO:0043138 ! 3'-5' DNA helicase activity + +[Term] +id: GO:0043141 +name: ATP-dependent 5'-3' DNA helicase activity +namespace: molecular_function +alt_id: GO:0008722 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] +synonym: "DNA helicase IV activity" NARROW [] +xref: EC:3.6.1.- +is_a: GO:0004003 ! ATP-dependent DNA helicase activity +is_a: GO:0043139 ! 5'-3' DNA helicase activity + +[Term] +id: GO:0043142 +name: single-stranded DNA-dependent ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single-stranded DNA; drives another reaction." [GOC:go_curators] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ssDNA-dependent ATPase activity" EXACT [] +is_a: GO:0008094 ! DNA-dependent ATPase activity + +[Term] +id: GO:0043143 +name: translational machinery localization +namespace: biological_process +def: "Any process by which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] +subset: gosubset_prok +synonym: "establishment and maintenance of translational machinery localization" EXACT [] +synonym: "establishment and maintenance of translational protein localization" EXACT [] +synonym: "translational protein localization" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0043144 +name: snoRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397] +is_a: GO:0016074 ! snoRNA metabolic process +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0043145 +name: snoRNA 3'-end cleavage +namespace: biological_process +def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397] +synonym: "snoRNA 3' end cleavage" EXACT [] +is_a: GO:0031126 ! snoRNA 3'-end processing + +[Term] +id: GO:0043146 +name: spindle stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of the spindle." [GOC:go_curators] +is_a: GO:0007026 ! negative regulation of microtubule depolymerization +relationship: part_of GO:0007051 ! spindle organization + +[Term] +id: GO:0043147 +name: meiotic spindle stabilization +namespace: biological_process +def: "The cell cycle process whereby spindle integrity is maintained during M phase of meiosis." [GOC:go_curators] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0043146 ! spindle stabilization +relationship: part_of GO:0000212 ! meiotic spindle organization + +[Term] +id: GO:0043148 +name: mitotic spindle stabilization +namespace: biological_process +def: "The cell cycle process whereby spindle integrity is maintained during M phase of mitosis." [GOC:go_curators] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0043146 ! spindle stabilization +relationship: part_of GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0043149 +name: stress fiber formation +namespace: biological_process +def: "Assembly of a stress fiber, the bundle of microfilaments and other proteins found in fibroblasts." [GOC:go_curators] +synonym: "stress fibre biosynthesis" EXACT [] +synonym: "stress fibre formation" EXACT [] +is_a: GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0043150 +name: DNA synthesis during double-strand break repair via homologous recombination +namespace: biological_process +def: "The synthesis of DNA during the process of double-strand break repair via homologous recombination." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0000731 ! DNA synthesis during DNA repair +relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0043151 +name: DNA synthesis during double-strand break repair via single-strand annealing +namespace: biological_process +def: "The synthesis of DNA during the process of double-strand break repair via single-strand annealing." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0000731 ! DNA synthesis during DNA repair +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0043152 +name: induction of bacterial agglutination +namespace: biological_process +def: "Any process by which infecting bacteria are clumped together by a host organism." [GOC:jl] +is_a: GO:0019731 ! antibacterial humoral response + +[Term] +id: GO:0043153 +name: entrainment of circadian clock by photoperiod +namespace: biological_process +def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] +is_a: GO:0009648 ! photoperiodism +is_a: GO:0009649 ! entrainment of circadian clock + +[Term] +id: GO:0043154 +name: negative regulation of caspase activity +namespace: biological_process +alt_id: GO:0001719 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of caspase activity." [GOC:jl] +synonym: "down regulation of caspase activity" EXACT [] +synonym: "down-regulation of caspase activity" EXACT [] +synonym: "downregulation of caspase activity" EXACT [] +synonym: "inhibition of caspase activation" NARROW [] +synonym: "inhibition of caspase activity" NARROW [] +synonym: "negative regulation of caspase activation" EXACT [] +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:0043281 ! regulation of caspase activity + +[Term] +id: GO:0043155 +name: negative regulation of photosynthesis, light reaction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] +synonym: "down regulation of photosynthesis, light reaction" EXACT [] +synonym: "down-regulation of photosynthesis, light reaction" EXACT [] +synonym: "downregulation of photosynthesis, light reaction" EXACT [] +synonym: "inhibition of photosynthesis, light reaction" NARROW [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0042548 ! regulation of photosynthesis, light reaction +relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0043156 +name: chromatin remodeling in response to cation stress +namespace: biological_process +def: "Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213] +is_a: GO:0006338 ! chromatin remodeling +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0043157 ! response to cation stress + +[Term] +id: GO:0043157 +name: response to cation stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213] +subset: gosubset_prok +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0043158 +name: heterocyst differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl] +subset: gosubset_prok +synonym: "heterocyst biosynthesis" EXACT [] +synonym: "heterocyst cell differentiation" EXACT [] +synonym: "heterocyst formation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0043159 +name: acrosomal matrix +namespace: cellular_component +def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] +is_a: GO:0044433 ! cytoplasmic vesicle part +is_a: GO:0044437 ! vacuolar part +relationship: part_of GO:0001669 ! acrosome + +[Term] +id: GO:0043160 +name: acrosomal lumen +namespace: cellular_component +def: "The volume enclosed within the acrosome membrane." [GOC:go_curators] +is_a: GO:0043202 ! lysosomal lumen +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0001669 ! acrosome + +[Term] +id: GO:0043161 +name: proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] +synonym: "proteasomal pathway" EXACT [] +synonym: "proteasomal processing" RELATED [] +synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT [] +synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT [] +synonym: "proteasome pathway" RELATED [] +xref: Reactome:174255 +xref: Reactome:207085 +xref: Reactome:216650 +xref: Reactome:225535 +xref: Reactome:234184 +xref: Reactome:241911 +xref: Reactome:261013 +xref: Reactome:266988 +xref: Reactome:271929 +xref: Reactome:277894 +xref: Reactome:284842 +is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process +is_a: GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:0043162 +name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343] +synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT [] +synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT [] +is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0043163 +name: cell envelope organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +synonym: "cell envelope organisation and biogenesis" EXACT [] +synonym: "cell envelope organization and biogenesis" EXACT [] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0043164 +name: Gram-negative-bacterium-type cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893] +subset: gosubset_prok +synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT [] +synonym: "cell wall anabolism (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall anabolism (sensu Proteobacteria)" EXACT [] +synonym: "cell wall assembly (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall assembly (sensu Proteobacteria)" EXACT [] +synonym: "cell wall biosynthesis (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall biosynthetic process (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall biosynthetic process (sensu Proteobacteria)" EXACT [] +synonym: "cell wall formation (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall formation (sensu Proteobacteria)" EXACT [] +synonym: "cell wall synthesis (sensu Gram-negative Bacteria)" EXACT [] +synonym: "cell wall synthesis (sensu Proteobacteria)" EXACT [] +is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis +relationship: part_of GO:0043163 ! cell envelope organization + +[Term] +id: GO:0043165 +name: cell outer membrane biogenesis +namespace: biological_process +def: "The assembly of an outer membrane, a lipid bilayer that forms the outermost layer of the cell envelope typical of Gram-negative bacteria, which is enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254] +subset: gosubset_prok +synonym: "outer membrane biogenesis (sensu Gram-negative Bacteria)" EXACT [] +synonym: "outer membrane biogenesis (sensu Proteobacteria)" EXACT [] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0043163 ! cell envelope organization + +[Term] +id: GO:0043166 +name: H4/H2A histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H4 and (to a lesser extent) H2A." [GOC:jl, PMID:10911987, PMID:9241414] +synonym: "H4/H2A acetyltransferase activity" EXACT [] +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0043167 +name: ion binding +namespace: molecular_function +def: "Interacting selectively with ions, charged atoms or groups of atoms." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +synonym: "atom binding" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043168 +name: anion binding +namespace: molecular_function +def: "Interacting selectively with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043167 ! ion binding + +[Term] +id: GO:0043169 +name: cation binding +namespace: molecular_function +def: "Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043167 ! ion binding + +[Term] +id: GO:0043170 +name: macromolecule metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33839, GOC:mah] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "macromolecule metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0043171 +name: peptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] +subset: gosubset_prok +synonym: "peptide breakdown" EXACT [] +synonym: "peptide catabolism" EXACT [] +synonym: "peptide degradation" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0043172 +name: ferredoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ferredoxin anabolism" EXACT [] +synonym: "ferredoxin biosynthesis" EXACT [] +synonym: "ferredoxin formation" EXACT [] +synonym: "ferredoxin synthesis" EXACT [] +is_a: GO:0006124 ! ferredoxin metabolic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process + +[Term] +id: GO:0043173 +name: nucleotide salvage +namespace: biological_process +def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043174 +name: nucleoside salvage +namespace: biological_process +def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043175 +name: RNA polymerase core enzyme binding +namespace: molecular_function +def: "Interacting selectively with the prokaryotic RNA polymerase core enzyme, the part of the RNA polymerase consisting of two alpha, one beta and one beta prime subunits." [GOC:jl, ISBN:0321000382] +subset: gosubset_prok +is_a: GO:0070063 ! RNA polymerase binding + +[Term] +id: GO:0043176 +name: amine binding +namespace: molecular_function +def: "Interacting selectively with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043177 +name: organic acid binding +namespace: molecular_function +def: "Interacting selectively with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043178 +name: alcohol binding +namespace: molecular_function +def: "Interacting selectively with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043179 +name: rhythmic excitation +namespace: biological_process +def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433] +is_a: GO:0060024 ! rhythmic synaptic transmission + +[Term] +id: GO:0043180 +name: rhythmic inhibition +namespace: biological_process +def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators] +is_a: GO:0060024 ! rhythmic synaptic transmission + +[Term] +id: GO:0043181 +name: vacuolar sequestering +namespace: biological_process +def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl] +synonym: "retention in vacuole" EXACT [] +synonym: "sequestering in vacuole" EXACT [] +synonym: "sequestration in vacuole" EXACT [] +synonym: "storage in vacuole" EXACT [] +synonym: "vacuolar retention" EXACT [] +synonym: "vacuolar sequestration" EXACT [] +synonym: "vacuolar storage" EXACT [] +is_a: GO:0051651 ! maintenance of location in cell + +[Term] +id: GO:0043182 +name: vacuolar sequestering of sodium ion +namespace: biological_process +def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl] +synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT [] +synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT [] +synonym: "sodium ion (Na+) retention in vacuole" EXACT [] +synonym: "sodium ion (Na+) storage in vacuole" EXACT [] +synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT [] +synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT [] +synonym: "vacuolar sodium ion (Na+) retention" EXACT [] +synonym: "vacuolar sodium ion (Na+) storage" EXACT [] +is_a: GO:0043181 ! vacuolar sequestering +relationship: part_of GO:0006883 ! cellular sodium ion homeostasis + +[Term] +id: GO:0043183 +name: vascular endothelial growth factor receptor 1 binding +namespace: molecular_function +def: "Interacting selectively with vascular endothelial growth factor receptor 1." [GOC:st] +synonym: "Flt-1 binding" EXACT [] +synonym: "VEGF receptor 1 binding" EXACT [] +synonym: "VEGFR 1 binding" EXACT [] +is_a: GO:0005172 ! vascular endothelial growth factor receptor binding + +[Term] +id: GO:0043184 +name: vascular endothelial growth factor receptor 2 binding +namespace: molecular_function +def: "Interacting selectively with vascular endothelial growth factor receptor 2." [GOC:st] +synonym: "Flk-1 binding" EXACT [] +synonym: "KDR binding" BROAD [] +synonym: "kinase domain region binding" EXACT [] +synonym: "VEGF receptor 2 binding" EXACT [] +synonym: "VEGFR 2 binding" EXACT [] +is_a: GO:0005172 ! vascular endothelial growth factor receptor binding + +[Term] +id: GO:0043185 +name: vascular endothelial growth factor receptor 3 binding +namespace: molecular_function +def: "Interacting selectively with vascular endothelial growth factor receptor 3." [GOC:st] +synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT [] +synonym: "VEGF receptor 3 binding" EXACT [] +synonym: "VEGFR 3 binding" EXACT [] +is_a: GO:0005172 ! vascular endothelial growth factor receptor binding + +[Term] +id: GO:0043186 +name: P granule +namespace: cellular_component +alt_id: GO:0018994 +def: "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] +synonym: "germline granule" EXACT [] +synonym: "nuage" BROAD [] +synonym: "polar granule" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0060293 ! germ plasm + +[Term] +id: GO:0043187 +name: cell septum surface +namespace: cellular_component +def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators] +synonym: "septum surface" BROAD [] +is_a: GO:0044457 ! cell septum part + +[Term] +id: GO:0043188 +name: cell septum edging +namespace: cellular_component +def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw] +synonym: "septum edging" BROAD [] +synonym: "septum edging (sensu Fungi)" EXACT [] +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0043189 +name: H4/H2A histone acetyltransferase complex +namespace: cellular_component +def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah] +synonym: "H4/H2A HAT complex" EXACT [] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0043190 +name: ATP-binding cassette (ABC) transporter complex +namespace: cellular_component +alt_id: GO:0043191 +alt_id: GO:0043192 +def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] +subset: goslim_pir +subset: gosubset_prok +synonym: "ABC-type efflux permease activity" NARROW [] +synonym: "ABC-type efflux porter activity" NARROW [] +synonym: "ABC-type uptake permease activity" NARROW [] +synonym: "ATP-binding cassette (ABC) transporter activity" RELATED [] +synonym: "ATP-binding cassette (ABC) transporter complex (sensu Bacteria and Archaea)" EXACT [] +synonym: "ATP-binding cassette (ABC) transporter complex (sensu Eukaryota)" EXACT [] +synonym: "mating pheromone exporter" NARROW [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0043193 +name: positive regulation of gene-specific transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the DNA-dependent transcription of a specific gene or genes." [GOC:jl] +subset: gosubset_prok +synonym: "activation of gene-specific transcription" NARROW [] +synonym: "stimulation of gene-specific transcription" NARROW [] +synonym: "up regulation of gene-specific transcription" EXACT [] +synonym: "up-regulation of gene-specific transcription" EXACT [] +synonym: "upregulation of gene-specific transcription" EXACT [] +is_a: GO:0032583 ! regulation of gene-specific transcription +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent + +[Term] +id: GO:0043194 +name: initial segment +namespace: cellular_component +def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0043195 +name: terminal button +namespace: cellular_component +def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] +synonym: "bouton" EXACT [] +synonym: "presynaptic bouton" EXACT [] +synonym: "synaptic bouton" EXACT [] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0043196 +name: varicosity +namespace: cellular_component +def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0043197 +name: dendritic spine +namespace: cellular_component +def: "Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln] +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0043198 +name: dendritic shaft +namespace: cellular_component +def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln] +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0043199 +name: sulfate binding +namespace: molecular_function +def: "Interacting selectively with sulfate (SO42-), a negatively charged small molecule." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0043200 +name: response to amino acid stimulus +namespace: biological_process +alt_id: GO:0010237 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:ef, GOC:mlg] +synonym: "response to amino acid" EXACT [] +is_a: GO:0001101 ! response to acid +is_a: GO:0014075 ! response to amine stimulus + +[Term] +id: GO:0043201 +name: response to leucine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg] +is_a: GO:0043200 ! response to amino acid stimulus + +[Term] +id: GO:0043202 +name: lysosomal lumen +namespace: cellular_component +def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0043203 +name: axon hillock +namespace: cellular_component +def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0043025 ! cell soma + +[Term] +id: GO:0043204 +name: perikaryon +namespace: cellular_component +def: "The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl] +synonym: "cell soma cytoplasm" RELATED [] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0043025 ! cell soma + +[Term] +id: GO:0043205 +name: fibril +namespace: cellular_component +def: "Extracellular matrix material consisting of polysaccharides and protein." [PMID:12704238] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0043206 +name: fibril organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of fibrils, extracellular matrix material consisting of polysaccharides and protein." [GOC:mlg] +synonym: "fibril organisation and biogenesis" EXACT [] +synonym: "fibril organization and biogenesis" EXACT [] +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0043207 +name: response to external biotic stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0043208 +name: glycosphingolipid binding +namespace: molecular_function +def: "Interacting selectively with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl] +is_a: GO:0046625 ! sphingolipid binding +is_a: GO:0051861 ! glycolipid binding + +[Term] +id: GO:0043209 +name: myelin sheath +namespace: cellular_component +def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:jl, http://en.wikipedia.org/] +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0043210 +name: alkanesulfonate binding +namespace: molecular_function +def: "Interacting selectively with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0043211 +name: carbohydrate-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of carbohydrates across a membrane." [GOC:mlg] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "carbohydrate ABC transporter" NARROW [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0043212 +name: carbohydrate-exporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) = ADP + phosphate + carbohydrate(out)." [GOC:mlg] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0043211 ! carbohydrate-transporting ATPase activity + +[Term] +id: GO:0043213 +name: bacteriocin transport +namespace: biological_process +def: "The directed movement of a bacteriocin into, out of, within or between cells. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0043214 +name: bacteriocin-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane." [GOC:mlg] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "bacteriocin ABC transporter" NARROW [] +is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity + +[Term] +id: GO:0043215 +name: daunorubicin transport +namespace: biological_process +def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of, within or between cells." [GOC:jl, GOC:mlg, http://www.mercksource.com/] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0043216 +name: daunorubicin-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "daunorubicin ABC transporter" NARROW [] +is_a: GO:0015238 ! drug transporter activity +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0043217 +name: myelin maintenance +namespace: biological_process +def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh] +is_a: GO:0007009 ! plasma membrane organization +relationship: part_of GO:0042552 ! myelination + +[Term] +id: GO:0043218 +name: compact myelin +namespace: cellular_component +def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0043219 +name: lateral loop +namespace: cellular_component +def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0043220 +name: Schmidt-Lanterman cleft +namespace: cellular_component +def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman clefts occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0043221 +name: SMC protein binding +namespace: molecular_function +def: "Interacting selectively with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, PMID:9640531] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043222 +name: SMC/kleisin ring complex +namespace: cellular_component +def: "A molecular ring complex composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1 and Smc3, and the kleisin protein Scc1." [GOC:jl, PMID:12667442] +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0043223 +name: cytoplasmic SCF ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] +synonym: "cytoplasmic cullin complex" EXACT [] +synonym: "cytoplasmic SCF complex" EXACT [] +synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT [] +is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0043224 +name: nuclear SCF ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] +synonym: "nuclear cullin complex" EXACT [] +synonym: "nuclear SCF complex" EXACT [] +synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT [] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0043225 +name: anion transmembrane-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in)." [GOC:mlg] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "anion ABC transporter" NARROW [] +synonym: "anion-transporting ATPase activity" EXACT [] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions + +[Term] +id: GO:0043226 +name: organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0043227 +name: membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] +subset: gosubset_prok +synonym: "membrane-enclosed organelle" EXACT [] +is_a: GO:0043226 ! organelle + +[Term] +id: GO:0043228 +name: non-membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] +subset: gosubset_prok +synonym: "non-membrane-enclosed organelle" EXACT [] +is_a: GO:0043226 ! organelle + +[Term] +id: GO:0043229 +name: intracellular organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043226 ! organelle +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0043230 +name: extracellular organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043226 ! organelle +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0043231 +name: intracellular membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +synonym: "intracellular membrane-enclosed organelle" EXACT [] +is_a: GO:0043227 ! membrane-bounded organelle +is_a: GO:0043229 ! intracellular organelle + +[Term] +id: GO:0043232 +name: intracellular non-membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +synonym: "intracellular non-membrane-enclosed organelle" EXACT [] +is_a: GO:0043228 ! non-membrane-bounded organelle +is_a: GO:0043229 ! intracellular organelle + +[Term] +id: GO:0043233 +name: organelle lumen +namespace: cellular_component +def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] +is_a: GO:0031974 ! membrane-enclosed lumen +is_a: GO:0044422 ! organelle part + +[Term] +id: GO:0043234 +name: protein complex +namespace: cellular_component +def: "Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups." [GOC:go_curators] +comment: Note that although at some level almost all cellular components can be thought of as protein complexes, this term is intended to exclude structures composed of the same repeating subunit or subunits, for example microtubules. Protein complexes encompassed by this term are generally not structural, and usually have a defined set of subunits. +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +synonym: "protein-protein complex" EXACT [] +is_a: GO:0032991 ! macromolecular complex + +[Term] +id: GO:0043235 +name: receptor complex +namespace: cellular_component +def: "Any protein group composed of two or more subunits, which may or may not be identical, which undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0043236 +name: laminin binding +namespace: molecular_function +def: "Interacting selectively with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd] +is_a: GO:0005515 ! protein binding +is_a: GO:0050840 ! extracellular matrix binding + +[Term] +id: GO:0043237 +name: laminin-1 binding +namespace: molecular_function +def: "Interacting selectively with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators] +is_a: GO:0043236 ! laminin binding + +[Term] +id: GO:0043238 +name: laminin-2 binding +namespace: molecular_function +def: "Interacting selectively with laminin-2, a glycoprotein trimer with the subunit composition alpha2, beta1, gamma 1." [GOC:go_curators] +is_a: GO:0043236 ! laminin binding + +[Term] +id: GO:0043239 +name: laminin-4 binding +namespace: molecular_function +def: "Interacting selectively with laminin-4, a glycoprotein trimer with the subunit composition alpha2, beta2, gamma 1." [GOC:go_curators] +is_a: GO:0043236 ! laminin binding + +[Term] +id: GO:0043240 +name: Fanconi anaemia nuclear complex +namespace: cellular_component +def: "A protein complex composed of the Fanconi anaemia (FA) proteins A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742] +synonym: "FA complex" EXACT [] +synonym: "FA nuclear complex" EXACT [] +synonym: "Fanconi anaemia complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044451 ! nucleoplasm part + +[Term] +id: GO:0043241 +name: protein complex disassembly +namespace: biological_process +def: "The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] +subset: gosubset_prok +is_a: GO:0032984 ! macromolecular complex disassembly + +[Term] +id: GO:0043242 +name: negative regulation of protein complex disassembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] +synonym: "down regulation of protein complex disassembly" EXACT [] +synonym: "down-regulation of protein complex disassembly" EXACT [] +synonym: "downregulation of protein complex disassembly" EXACT [] +synonym: "inhibition of protein complex disassembly" NARROW [] +is_a: GO:0043244 ! regulation of protein complex disassembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0043241 ! protein complex disassembly + +[Term] +id: GO:0043243 +name: positive regulation of protein complex disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] +synonym: "activation of protein complex disassembly" NARROW [] +synonym: "stimulation of protein complex disassembly" NARROW [] +synonym: "up regulation of protein complex disassembly" EXACT [] +synonym: "up-regulation of protein complex disassembly" EXACT [] +synonym: "upregulation of protein complex disassembly" EXACT [] +is_a: GO:0043244 ! regulation of protein complex disassembly +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0043241 ! protein complex disassembly + +[Term] +id: GO:0043244 +name: regulation of protein complex disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] +subset: gosubset_prok +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0043241 ! protein complex disassembly + +[Term] +id: GO:0043245 +name: extraorganismal space +namespace: cellular_component +def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0043246 +name: megasome +namespace: cellular_component +def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [http://cancerweb.ncl.ac.uk/, PMID:11206117, PMID:1999020] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0043247 +name: telomere maintenance in response to DNA damage +namespace: biological_process +def: "Any process that occur in response to the presence of critically short telomeres." [PMID:15279784] +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0034984 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0043248 +name: proteasome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471] +subset: gosubset_prok +synonym: "proteasome complex assembly" EXACT [] +synonym: "proteasome maturation" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0043249 +name: erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] +synonym: "RBC maturation" EXACT [] +synonym: "red blood cell maturation" EXACT [] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048821 ! erythrocyte development + +[Term] +id: GO:0043250 +name: sodium-dependent organic anion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0043251 +name: sodium-dependent organic anion transport +namespace: biological_process +def: "The directed, sodium-dependent, movement of organic anions into, out of, within or between cells." [GOC:go_curators] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0043252 +name: sodium-independent organic anion transport +namespace: biological_process +def: "The directed, sodium-independent, movement of organic anions into, out of, within or between cells." [GOC:go_curators] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0043253 +name: chloroplast ribosome +namespace: cellular_component +def: "A ribosome contained within a chloroplast." [GOC:ecd] +is_a: GO:0009547 ! plastid ribosome +is_a: GO:0044434 ! chloroplast part +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0043254 +name: regulation of protein complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] +subset: gosubset_prok +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006461 ! protein complex assembly + +[Term] +id: GO:0043255 +name: regulation of carbohydrate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] +subset: gosubset_prok +synonym: "regulation of carbohydrate anabolism" EXACT [] +synonym: "regulation of carbohydrate biosynthesis" EXACT [] +synonym: "regulation of carbohydrate formation" EXACT [] +synonym: "regulation of carbohydrate synthesis" EXACT [] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009889 ! regulation of biosynthetic process +relationship: regulates GO:0016051 ! carbohydrate biosynthetic process + +[Term] +id: GO:0043256 +name: laminin complex +namespace: cellular_component +def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354] +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0005605 ! basal lamina + +[Term] +id: GO:0043257 +name: laminin-8 complex +namespace: cellular_component +def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043258 +name: laminin-9 complex +namespace: cellular_component +def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043259 +name: laminin-10 complex +namespace: cellular_component +def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043260 +name: laminin-11 complex +namespace: cellular_component +def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043261 +name: laminin-12 complex +namespace: cellular_component +def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043262 +name: adenosine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606] +synonym: "adenosine diphosphatase activity" EXACT [] +synonym: "adenosinepyrophosphatase activity" EXACT [EC:3.6.1.6] +synonym: "ADPase" BROAD [EC:3.6.1.3] +synonym: "ADPase activity" EXACT [EC:3.6.1.6] +synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.3] +synonym: "ATP diphosphohydrolase (phosphate-forming) activity" EXACT [EC:3.6.1.3] +synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.3] +synonym: "ATP-diphosphohydrolase activity" EXACT [EC:3.6.1.3] +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0043263 +name: cellulosome +namespace: cellular_component +def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609] +subset: gosubset_prok +is_a: GO:0043264 ! extracellular non-membrane-bounded organelle + +[Term] +id: GO:0043264 +name: extracellular non-membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] +subset: gosubset_prok +synonym: "extracellular non-membrane-enclosed organelle" EXACT [] +is_a: GO:0043228 ! non-membrane-bounded organelle +is_a: GO:0043230 ! extracellular organelle + +[Term] +id: GO:0043265 +name: ectoplasm +namespace: cellular_component +def: "Granule free cytoplasm, lying immediately below the plasma membrane." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0043266 +name: regulation of potassium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells." [GOC:jl] +synonym: "regulation of K+ conductance" NARROW [] +synonym: "regulation of K+ transport" EXACT [] +synonym: "regulation of potassium conductance" NARROW [] +synonym: "regulation of potassium ion conductance" NARROW [] +synonym: "regulation of potassium transport" EXACT [] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0006813 ! potassium ion transport + +[Term] +id: GO:0043267 +name: negative regulation of potassium ion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells." [GOC:jl] +synonym: "down regulation of potassium ion transport" EXACT [] +synonym: "down-regulation of potassium ion transport" EXACT [] +synonym: "downregulation of potassium ion transport" EXACT [] +synonym: "inhibition of potassium ion transport" NARROW [] +synonym: "negative regulation of K+ transport" EXACT [] +synonym: "negative regulation of potassium ion conductance" NARROW [] +synonym: "negative regulation of potassium transport" EXACT [] +synonym: "regulation of K+ conductance" NARROW [] +synonym: "regulation of potassium conductance" NARROW [] +synonym: "transmembrane conductance regulator activity" RELATED [] +is_a: GO:0043266 ! regulation of potassium ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0006813 ! potassium ion transport + +[Term] +id: GO:0043268 +name: positive regulation of potassium ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells." [GOC:jl] +synonym: "activation of potassium ion transport" NARROW [] +synonym: "positive regulation of K+ conductance" NARROW [] +synonym: "positive regulation of K+ transport" EXACT [] +synonym: "positive regulation of potassium conductance" NARROW [] +synonym: "positive regulation of potassium ion conductance" NARROW [] +synonym: "positive regulation of potassium transport" EXACT [] +synonym: "stimulation of potassium ion transport" NARROW [] +synonym: "up regulation of potassium ion transport" EXACT [] +synonym: "up-regulation of potassium ion transport" EXACT [] +synonym: "upregulation of potassium ion transport" EXACT [] +is_a: GO:0043266 ! regulation of potassium ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0006813 ! potassium ion transport + +[Term] +id: GO:0043269 +name: regulation of ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells." [GOC:jl] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0006811 ! ion transport + +[Term] +id: GO:0043270 +name: positive regulation of ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells." [GOC:jl] +synonym: "activation of ion transport" NARROW [] +synonym: "stimulation of ion transport" NARROW [] +synonym: "up regulation of ion transport" EXACT [] +synonym: "up-regulation of ion transport" EXACT [] +synonym: "upregulation of ion transport" EXACT [] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0006811 ! ion transport + +[Term] +id: GO:0043271 +name: negative regulation of ion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells." [GOC:jl] +synonym: "down regulation of ion transport" EXACT [] +synonym: "down-regulation of ion transport" EXACT [] +synonym: "downregulation of ion transport" EXACT [] +synonym: "inhibition of ion transport" NARROW [] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0006811 ! ion transport + +[Term] +id: GO:0043272 +name: ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring during the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl] +synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" EXACT [] +synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" EXACT [] +synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" EXACT [] +is_a: GO:0009693 ! ethylene biosynthetic process +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0043273 +name: CTPase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators] +synonym: "cytidine triphosphatase activity" EXACT [] +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0043274 +name: phospholipase binding +namespace: molecular_function +def: "Interacting selectively with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0043275 +name: glutamate carboxypeptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl] +comment: This term was made obsolete because it represents a gene product. +synonym: "acetylaspartylglutamate dipeptidase activity" EXACT [] +synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] +synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21] +synonym: "mGCP" RELATED [EC:3.4.17.21] +synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21] +synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21] +synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21] +synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21] +synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21] +synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21] +synonym: "NAALADase activity" EXACT [EC:3.4.17.21] +synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21] +synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21] +synonym: "PSM antigen" RELATED [EC:3.4.17.21] +synonym: "PSMA" RELATED [EC:3.4.17.21] +synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21] +synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21] +synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21] +synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21] +synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21] +synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21] +xref: EC:3.4.17.21 +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0043276 +name: anoikis +namespace: biological_process +def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/] +synonym: "detachment induced cell death" EXACT [] +synonym: "suspension induced apoptosis" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0043277 +name: apoptotic cell clearance +namespace: biological_process +def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] +comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. +synonym: "apoptotic cell removal" EXACT [] +synonym: "programmed cell clearance" EXACT [] +is_a: GO:0006909 ! phagocytosis +relationship: part_of GO:0008632 ! apoptotic program + +[Term] +id: GO:0043278 +name: response to morphine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [CHEBI:17303, GOC:ef, GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0014072 ! response to isoquinoline alkaloid +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0043279 +name: response to alkaloid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0043280 +name: positive regulation of caspase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl] +synonym: "activation of caspase activity" NARROW [] +synonym: "stimulation of caspase activity" NARROW [] +synonym: "up regulation of caspase activity" EXACT [] +synonym: "up-regulation of caspase activity" EXACT [] +synonym: "upregulation of caspase activity" EXACT [] +is_a: GO:0043281 ! regulation of caspase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0043281 +name: regulation of caspase activity +namespace: biological_process +alt_id: GO:0043026 +def: "Any process that modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl] +synonym: "regulation of caspase activation" NARROW [] +is_a: GO:0042981 ! regulation of apoptosis +is_a: GO:0052548 ! regulation of endopeptidase activity + +[Term] +id: GO:0043282 +name: pharyngeal muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. The pharyngeal muscle mediates feeding in nematodes." [GOC:go_curators] +is_a: GO:0007517 ! muscle development + +[Term] +id: GO:0043283 +name: biopolymer metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins." [GOC:jl, http://en.wikipedia.org/] +subset: goslim_pir +subset: gosubset_prok +synonym: "biopolymer metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0043284 +name: biopolymer biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins." [GOC:jl, http://en.wikipedia.org/] +subset: goslim_pir +subset: gosubset_prok +synonym: "biopolymer anabolism" EXACT [] +synonym: "biopolymer biosynthesis" EXACT [] +synonym: "biopolymer formation" EXACT [] +synonym: "biopolymer synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0043283 ! biopolymer metabolic process + +[Term] +id: GO:0043285 +name: biopolymer catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins." [GOC:jl, http://en.wikipedia.org/] +subset: goslim_pir +subset: gosubset_prok +synonym: "biopolymer breakdown" EXACT [] +synonym: "biopolymer catabolism" EXACT [] +synonym: "biopolymer degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0043283 ! biopolymer metabolic process + +[Term] +id: GO:0043286 +name: regulation of poly(3-hydroxyalkanoate) biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] +subset: gosubset_prok +synonym: "regulation of PHA" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process + +[Term] +id: GO:0043287 +name: poly(3-hydroxyalkanoate) binding +namespace: molecular_function +def: "Interacting selectively with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] +subset: gosubset_prok +synonym: "PHA binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043288 +name: apocarotenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] +subset: gosubset_prok +synonym: "apocarotenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0043289 +name: apocarotenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] +subset: gosubset_prok +synonym: "apocarotenoid anabolism" EXACT [] +synonym: "apocarotenoid biosynthesis" EXACT [] +synonym: "apocarotenoid formation" EXACT [] +synonym: "apocarotenoid synthesis" EXACT [] +is_a: GO:0043288 ! apocarotenoid metabolic process + +[Term] +id: GO:0043290 +name: apocarotenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] +subset: gosubset_prok +synonym: "apocarotenoid breakdown" EXACT [] +synonym: "apocarotenoid catabolism" EXACT [] +synonym: "apocarotenoid degradation" EXACT [] +is_a: GO:0043288 ! apocarotenoid metabolic process + +[Term] +id: GO:0043291 +name: RAVE complex +namespace: cellular_component +def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802] +synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0043292 +name: contractile fiber +namespace: cellular_component +def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] +synonym: "contractile fibre" EXACT [] +synonym: "muscle fiber" BROAD [] +synonym: "muscle fibre" BROAD [] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0043293 +name: apoptosome +namespace: cellular_component +def: "A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0043294 +name: mitochondrial glutamate synthase complex (NADH) +namespace: cellular_component +def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] +is_a: GO:0031027 ! glutamate synthase complex (NADH) +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0043295 +name: glutathione binding +namespace: molecular_function +def: "Interacting selectively with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0043296 +name: apical junction complex +namespace: cellular_component +def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, PMID:12525486, PMID:15196556] +synonym: "apical cell junction complex" EXACT [GOC:mah] +is_a: GO:0005911 ! cell-cell junction +relationship: part_of GO:0016327 ! apicolateral plasma membrane + +[Term] +id: GO:0043297 +name: apical junction assembly +namespace: biological_process +def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] +is_a: GO:0007043 ! cell-cell junction assembly + +[Term] +id: GO:0043299 +name: leukocyte degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules by a leukocyte." [GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] +comment: This term was improved by GO_REF:0000022. It was moved. +synonym: "immune cell degranulation" EXACT [] +synonym: "immune cell granule exocytosis" EXACT [] +synonym: "leucocyte degranulation" EXACT [] +synonym: "leukocyte granule exocytosis" EXACT [] +is_a: GO:0002252 ! immune effector process +is_a: GO:0006887 ! exocytosis +is_a: GO:0045055 ! regulated secretory pathway + +[Term] +id: GO:0043300 +name: regulation of leukocyte degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of immune cell degranulation" EXACT [] +synonym: "regulation of immune cell granule exocytosis" EXACT [] +synonym: "regulation of leucocyte degranulation" EXACT [] +synonym: "regulation of leukocyte granule exocytosis" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0017157 ! regulation of exocytosis +relationship: regulates GO:0043299 ! leukocyte degranulation + +[Term] +id: GO:0043301 +name: negative regulation of leukocyte degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of leukocyte degranulation" EXACT [] +synonym: "down-regulation of leukocyte degranulation" EXACT [] +synonym: "downregulation of leukocyte degranulation" EXACT [] +synonym: "inhibition of leukocyte degranulation" NARROW [] +synonym: "negative regulation of immune cell degranulation" EXACT [] +synonym: "negative regulation of leucocyte degranulation" EXACT [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0045920 ! negative regulation of exocytosis +relationship: negatively_regulates GO:0043299 ! leukocyte degranulation + +[Term] +id: GO:0043302 +name: positive regulation of leukocyte degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of leukocyte degranulation" NARROW [] +synonym: "positive regulation of immune cell degranulation" EXACT [] +synonym: "positive regulation of leucocyte degranulation" EXACT [] +synonym: "stimulation of leukocyte degranulation" NARROW [] +synonym: "up regulation of leukocyte degranulation" EXACT [] +synonym: "up-regulation of leukocyte degranulation" EXACT [] +synonym: "upregulation of leukocyte degranulation" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0045921 ! positive regulation of exocytosis +relationship: positively_regulates GO:0043299 ! leukocyte degranulation + +[Term] +id: GO:0043303 +name: mast cell degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "mast cell granule exocytosis" EXACT [] +is_a: GO:0043299 ! leukocyte degranulation +is_a: GO:0045576 ! mast cell activation +relationship: part_of GO:0002448 ! mast cell mediated immunity + +[Term] +id: GO:0043304 +name: regulation of mast cell degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of mast cell granule exocytosis" EXACT [] +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0033003 ! regulation of mast cell activation +is_a: GO:0043300 ! regulation of leukocyte degranulation +relationship: regulates GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0043305 +name: negative regulation of mast cell degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of mast cell degranulation" EXACT [] +synonym: "down-regulation of mast cell degranulation" EXACT [] +synonym: "downregulation of mast cell degranulation" EXACT [] +synonym: "inhibition of mast cell degranulation" NARROW [] +synonym: "negative regulation of mast cell granule exocytosis" EXACT [] +is_a: GO:0033004 ! negative regulation of mast cell activation +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043304 ! regulation of mast cell degranulation +relationship: negatively_regulates GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0043306 +name: positive regulation of mast cell degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of mast cell degranulation" NARROW [] +synonym: "positive regulation of mast cell granule exocytosis" EXACT [] +synonym: "stimulation of mast cell degranulation" NARROW [] +synonym: "up regulation of mast cell degranulation" EXACT [] +synonym: "up-regulation of mast cell degranulation" EXACT [] +synonym: "upregulation of mast cell degranulation" EXACT [] +is_a: GO:0033005 ! positive regulation of mast cell activation +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043304 ! regulation of mast cell degranulation +relationship: positively_regulates GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0043307 +name: eosinophil activation +namespace: biological_process +def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0043308 +name: eosinophil degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "eosinophil granule exocytosis" EXACT [] +is_a: GO:0043299 ! leukocyte degranulation +is_a: GO:0043307 ! eosinophil activation +relationship: part_of GO:0002447 ! eosinophil mediated immunity + +[Term] +id: GO:0043309 +name: regulation of eosinophil degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of eosinophil granule exocytosis" EXACT [] +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0043300 ! regulation of leukocyte degranulation +relationship: regulates GO:0043308 ! eosinophil degranulation + +[Term] +id: GO:0043310 +name: negative regulation of eosinophil degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of eosinophil degranulation" EXACT [] +synonym: "down-regulation of eosinophil degranulation" EXACT [] +synonym: "downregulation of eosinophil degranulation" EXACT [] +synonym: "inhibition of eosinophil degranulation" NARROW [] +synonym: "negative regulation of eosinophil granule exocytosis" EXACT [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043309 ! regulation of eosinophil degranulation +relationship: negatively_regulates GO:0043308 ! eosinophil degranulation + +[Term] +id: GO:0043311 +name: positive regulation of eosinophil degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of eosinophil degranulation" NARROW [] +synonym: "positive regulation of eosinophil granule exocytosis" EXACT [] +synonym: "stimulation of eosinophil degranulation" NARROW [] +synonym: "up regulation of eosinophil degranulation" EXACT [] +synonym: "up-regulation of eosinophil degranulation" EXACT [] +synonym: "upregulation of eosinophil degranulation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043309 ! regulation of eosinophil degranulation +relationship: positively_regulates GO:0043308 ! eosinophil degranulation + +[Term] +id: GO:0043312 +name: neutrophil degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "heterophil degranulation" RELATED [] +synonym: "neutrophil granule exocytosis" EXACT [] +is_a: GO:0042119 ! neutrophil activation +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0002446 ! neutrophil mediated immunity + +[Term] +id: GO:0043313 +name: regulation of neutrophil degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of neutrophil granule exocytosis" EXACT [] +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0043300 ! regulation of leukocyte degranulation +relationship: regulates GO:0043312 ! neutrophil degranulation + +[Term] +id: GO:0043314 +name: negative regulation of neutrophil degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of neutrophil degranulation" EXACT [] +synonym: "down-regulation of neutrophil degranulation" EXACT [] +synonym: "downregulation of neutrophil degranulation" EXACT [] +synonym: "inhibition of neutrophil degranulation" NARROW [] +synonym: "negative regulation of neutrophil granule exocytosis" EXACT [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043313 ! regulation of neutrophil degranulation +relationship: negatively_regulates GO:0043312 ! neutrophil degranulation + +[Term] +id: GO:0043315 +name: positive regulation of neutrophil degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of neutrophil degranulation" NARROW [] +synonym: "positive regulation of neutrophil granule exocytosis" EXACT [] +synonym: "stimulation of neutrophil degranulation" NARROW [] +synonym: "up regulation of neutrophil degranulation" EXACT [] +synonym: "up-regulation of neutrophil degranulation" EXACT [] +synonym: "upregulation of neutrophil degranulation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043313 ! regulation of neutrophil degranulation +relationship: positively_regulates GO:0043312 ! neutrophil degranulation + +[Term] +id: GO:0043316 +name: cytotoxic T cell degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "cytotoxic T cell granule exocytosis" EXACT [] +synonym: "cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "cytotoxic T-cell degranulation" EXACT [] +synonym: "cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT [] +is_a: GO:0042110 ! T cell activation +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0043317 +name: regulation of cytotoxic T cell degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT [] +synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "regulation of cytotoxic T-cell degranulation" EXACT [] +synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0043316 ! cytotoxic T cell degranulation + +[Term] +id: GO:0043318 +name: negative regulation of cytotoxic T cell degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "down-regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "downregulation of cytotoxic T cell degranulation" EXACT [] +synonym: "inhibition of cytotoxic T cell degranulation" NARROW [] +synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT [] +synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT [] +synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation + +[Term] +id: GO:0043319 +name: positive regulation of cytotoxic T cell degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of cytotoxic T cell degranulation" NARROW [] +synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT [] +synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT [] +synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] +synonym: "stimulation of cytotoxic T cell degranulation" NARROW [] +synonym: "up regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "up-regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "upregulation of cytotoxic T cell degranulation" EXACT [] +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation + +[Term] +id: GO:0043320 +name: natural killer cell degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "natural killer cell granule exocytosis" EXACT [] +synonym: "NK cell degranulation" EXACT [] +synonym: "NK cell granule exocytosis" EXACT [] +is_a: GO:0030101 ! natural killer cell activation +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0043321 +name: regulation of natural killer cell degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of natural killer cell granule exocytosis" EXACT [] +synonym: "regulation of NK cell degranulation" EXACT [] +synonym: "regulation of NK cell granule exocytosis" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +is_a: GO:0043300 ! regulation of leukocyte degranulation +relationship: regulates GO:0043320 ! natural killer cell degranulation + +[Term] +id: GO:0043322 +name: negative regulation of natural killer cell degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of natural killer cell degranulation" EXACT [] +synonym: "down-regulation of natural killer cell degranulation" EXACT [] +synonym: "downregulation of natural killer cell degranulation" EXACT [] +synonym: "inhibition of natural killer cell degranulation" NARROW [] +synonym: "negative regulation of natural killer cell granule exocytosis" EXACT [] +synonym: "negative regulation of NK cell degranulation" EXACT [] +synonym: "negative regulation of NK cell granule exocytosis" EXACT [] +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043321 ! regulation of natural killer cell degranulation +relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation + +[Term] +id: GO:0043323 +name: positive regulation of natural killer cell degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of natural killer cell degranulation" NARROW [] +synonym: "positive regulation of natural killer cell granule exocytosis" EXACT [] +synonym: "positive regulation of NK cell degranulation" EXACT [] +synonym: "positive regulation of NK cell granule exocytosis" EXACT [] +synonym: "stimulation of natural killer cell degranulation" NARROW [] +synonym: "up regulation of natural killer cell degranulation" EXACT [] +synonym: "up-regulation of natural killer cell degranulation" EXACT [] +synonym: "upregulation of natural killer cell degranulation" EXACT [] +is_a: GO:0032816 ! positive regulation of natural killer cell activation +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043321 ! regulation of natural killer cell degranulation +relationship: positively_regulates GO:0043320 ! natural killer cell degranulation + +[Term] +id: GO:0043324 +name: pigment metabolic process during developmental pigmentation +namespace: biological_process +def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin, occurring during the deposition of coloring matter in an organ or organism." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "pigment metabolic process during pigmentation during development" EXACT [] +synonym: "pigment metabolism during developmental pigmentation" EXACT [] +synonym: "pigment metabolism during pigmentation during development" EXACT [] +is_a: GO:0043474 ! pigment metabolic process during pigmentation +relationship: part_of GO:0048066 ! pigmentation during development + +[Term] +id: GO:0043325 +name: phosphatidylinositol-3,4-bisphosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol-3,4-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [GOC:go_curators] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0043326 +name: chemotaxis to folate +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0043327 +name: chemotaxis to cAMP +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators] +synonym: "chemotaxis to 3',5' cAMP" EXACT [] +synonym: "chemotaxis to 3',5'-cAMP" EXACT [] +synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [] +synonym: "chemotaxis to cyclic AMP" EXACT [] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0043328 +name: protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway +namespace: biological_process +def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring during protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl, PMID:11511343] +synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +is_a: GO:0006623 ! protein targeting to vacuole +is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway +relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway + +[Term] +id: GO:0043329 +name: protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway +namespace: biological_process +def: "The process of directing proteins towards a membrane using signals contained within the protein, occurring during ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl] +synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane +relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway + +[Term] +id: GO:0043330 +name: response to exogenous dsRNA +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators] +comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'. +synonym: "response to exogenous double-stranded RNA" EXACT [] +synonym: "response to viral dsRNA" NARROW [] +is_a: GO:0043331 ! response to dsRNA + +[Term] +id: GO:0043331 +name: response to dsRNA +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl] +synonym: "response to double-stranded RNA" EXACT [] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0043332 +name: mating projection tip +namespace: cellular_component +def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc] +synonym: "conjugation tube tip" NARROW [] +synonym: "shmoo tip" NARROW [] +is_a: GO:0030427 ! site of polarized growth +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0043333 +name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043334 +name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043335 +name: protein unfolding +namespace: biological_process +def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0043336 +name: site-specific telomere resolvase activity +namespace: molecular_function +def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598] +comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres. +synonym: "ResT" NARROW [] +synonym: "TelN" NARROW [] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0043337 +name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin)." [GOC:jl] +synonym: "cardiolipin synthase" BROAD [] +synonym: "cardiolipin synthetase" BROAD [] +is_a: GO:0030572 ! phosphatidyltransferase activity + +[Term] +id: GO:0043338 +name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase +namespace: molecular_function +def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477] +synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD [] +xref: EC:2.7.7.- +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0043353 +name: enucleate erythrocyte differentiation +namespace: biological_process +def: "The process by which a myeloid precursor cell acquires specializes features of an erythrocyte without a nucleus, as found in mammals." [GOC:go_curators] +synonym: "enucleate red blood cell differentiation" EXACT [] +synonym: "erythrocyte differentiation (sensu Mammalia)" EXACT [] +is_a: GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0043354 +name: enucleate erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators] +synonym: "enucleate red blood cell maturation" EXACT [] +synonym: "erythrocyte maturation (sensu Mammalia)" EXACT [] +is_a: GO:0043249 ! erythrocyte maturation +relationship: part_of GO:0048822 ! enucleate erythrocyte development + +[Term] +id: GO:0043362 +name: nucleate erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] +synonym: "nucleate red blood cell maturation" EXACT [] +is_a: GO:0043249 ! erythrocyte maturation +relationship: part_of GO:0048823 ! nucleate erythrocyte development + +[Term] +id: GO:0043363 +name: nucleate erythrocyte differentiation +namespace: biological_process +def: "The process by which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] +synonym: "nucleate red blood cell differentiation" EXACT [] +is_a: GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0043364 +name: catalysis of free radical formation +namespace: molecular_function +def: "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: goslim_pir +synonym: "catalysis of free radical generation" EXACT [] +synonym: "catalysis of free-radical biosynthesis" EXACT [] +synonym: "catalysis of free-radical formation" EXACT [] +synonym: "catalysis of free-radical generation" EXACT [] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0043365 +name: [formate-C-acetyltransferase]-activating enzyme activity +namespace: molecular_function +alt_id: GO:0008862 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl] +synonym: "[pyruvate formate-lyase]-activating enzyme activity" EXACT [EC:1.97.1.4] +synonym: "formate acetyltransferase activating enzyme activity" EXACT [EC:1.97.1.4] +synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" EXACT [EC:1.97.1.4] +synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" EXACT [EC:1.97.1.4] +synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4] +synonym: "PFL activase activity" EXACT [EC:1.97.1.4] +synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" EXACT [EC:1.97.1.4] +synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4] +xref: EC:1.97.1.4 +xref: MetaCyc:TDCEACT-RXN +is_a: GO:0016491 ! oxidoreductase activity +is_a: GO:0043364 ! catalysis of free radical formation + +[Term] +id: GO:0043366 +name: beta selection +namespace: biological_process +def: "The process by which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932] +is_a: GO:0045058 ! T cell selection +relationship: part_of GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0043367 +name: CD4-positive, alpha beta T cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0043368 +name: positive T cell selection +namespace: biological_process +def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] +synonym: "positive T lymphocyte selection" EXACT [] +synonym: "positive T-cell selection" EXACT [] +synonym: "positive T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection + +[Term] +id: GO:0043369 +name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] +synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0043368 ! positive T cell selection + +[Term] +id: GO:0043370 +name: regulation of CD4-positive, alpha beta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive T-cell differentiation" EXACT [] +synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: regulates GO:0043367 ! CD4-positive, alpha beta T cell differentiation + +[Term] +id: GO:0043371 +name: negative regulation of CD4-positive, alpha beta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW [] +synonym: "negative regulation of CD4-positive T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT [] +synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation +relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha beta T cell differentiation + +[Term] +id: GO:0043372 +name: positive regulation of CD4-positive, alpha beta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW [] +synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT [] +synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW [] +synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation +relationship: positively_regulates GO:0043367 ! CD4-positive, alpha beta T cell differentiation + +[Term] +id: GO:0043373 +name: CD4-positive, alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process by which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT [] +synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment +relationship: part_of GO:0043367 ! CD4-positive, alpha beta T cell differentiation + +[Term] +id: GO:0043374 +name: CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0043375 +name: CD8-positive, alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT [] +synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] +synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment +relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043376 +name: regulation of CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive T-cell differentiation" EXACT [] +synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043377 +name: negative regulation of CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW [] +synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT [] +synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation +is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation +relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043378 +name: positive regulation of CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW [] +synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT [] +synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW [] +synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation +is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation +relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043379 +name: memory T cell differentiation +namespace: biological_process +def: "The process whereby a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "memory T lymphocyte differentiation" EXACT [] +synonym: "memory T-cell differentiation" EXACT [] +synonym: "memory T-lymphocyte differentiation" EXACT [] +is_a: GO:0002292 ! T cell differentiation during immune response + +[Term] +id: GO:0043380 +name: regulation of memory T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of memory T lymphocyte differentiation" EXACT [] +synonym: "regulation of memory T-cell differentiation" EXACT [] +synonym: "regulation of memory T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0043379 ! memory T cell differentiation + +[Term] +id: GO:0043381 +name: negative regulation of memory T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of memory T cell differentiation" EXACT [] +synonym: "down-regulation of memory T cell differentiation" EXACT [] +synonym: "downregulation of memory T cell differentiation" EXACT [] +synonym: "inhibition of memory T cell differentiation" NARROW [] +synonym: "negative regulation of memory T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of memory T-cell differentiation" EXACT [] +synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043380 ! regulation of memory T cell differentiation +is_a: GO:0045581 ! negative regulation of T cell differentiation +relationship: negatively_regulates GO:0043379 ! memory T cell differentiation + +[Term] +id: GO:0043382 +name: positive regulation of memory T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of memory T cell differentiation" NARROW [] +synonym: "positive regulation of memory T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of memory T-cell differentiation" EXACT [] +synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of memory T cell differentiation" NARROW [] +synonym: "up regulation of memory T cell differentiation" EXACT [] +synonym: "up-regulation of memory T cell differentiation" EXACT [] +synonym: "upregulation of memory T cell differentiation" EXACT [] +is_a: GO:0043380 ! regulation of memory T cell differentiation +is_a: GO:0045582 ! positive regulation of T cell differentiation +relationship: positively_regulates GO:0043379 ! memory T cell differentiation + +[Term] +id: GO:0043383 +name: negative T cell selection +namespace: biological_process +def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] +synonym: "negative T lymphocyte selection" EXACT [] +synonym: "negative T-cell selection" EXACT [] +synonym: "negative T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection + +[Term] +id: GO:0043384 +name: pre-T cell receptor complex +namespace: cellular_component +def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932] +synonym: "pre-T lymphocyte receptor complex" EXACT [] +synonym: "pre-T-cell receptor complex" EXACT [] +synonym: "pre-T-lymphocyte receptor complex" EXACT [] +synonym: "pre-TCR complex" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0043385 +name: mycotoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "mycotoxin metabolism" EXACT [] +is_a: GO:0009404 ! toxin metabolic process + +[Term] +id: GO:0043386 +name: mycotoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "mycotoxin anabolism" EXACT [] +synonym: "mycotoxin biosynthesis" EXACT [] +synonym: "mycotoxin formation" EXACT [] +synonym: "mycotoxin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0043385 ! mycotoxin metabolic process + +[Term] +id: GO:0043387 +name: mycotoxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "mycotoxin breakdown" EXACT [] +synonym: "mycotoxin catabolism" EXACT [] +synonym: "mycotoxin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0043385 ! mycotoxin metabolic process + +[Term] +id: GO:0043388 +name: positive regulation of DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid." [GOC:jl] +subset: gosubset_prok +synonym: "activation of DNA binding" NARROW [] +synonym: "stimulation of DNA binding" NARROW [] +synonym: "up regulation of DNA binding" EXACT [] +synonym: "up-regulation of DNA binding" EXACT [] +synonym: "upregulation of DNA binding" EXACT [] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:0043389 +name: aflatoxin B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aflatoxins with a B designation. Distinguished from other aflatoxins by their exhibition of blue fluorescence under UV-light." [GOC:jl, http://www.ansci.cornell.edu/plants/toxicagents/aflatoxin/aflatoxin.html] +synonym: "aflatoxin B metabolism" EXACT [] +is_a: GO:0046222 ! aflatoxin metabolic process + +[Term] +id: GO:0043390 +name: aflatoxin B1 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "aflatoxin B1 metabolism" EXACT [] +is_a: GO:0043389 ! aflatoxin B metabolic process + +[Term] +id: GO:0043391 +name: aflatoxin B2 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius." [GOC:jl, http://www.aspergillus.man.ac.uk/] +synonym: "aflatoxin B2 metabolism" EXACT [] +is_a: GO:0043389 ! aflatoxin B metabolic process + +[Term] +id: GO:0043392 +name: negative regulation of DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid." [GOC:jl] +subset: gosubset_prok +synonym: "down regulation of DNA binding" EXACT [] +synonym: "down-regulation of DNA binding" EXACT [] +synonym: "downregulation of DNA binding" EXACT [] +synonym: "inhibition of DNA binding" NARROW [] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:0043393 +name: regulation of protein binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0043394 +name: proteoglycan binding +namespace: molecular_function +def: "Interacting selectively with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0001948 ! glycoprotein binding + +[Term] +id: GO:0043395 +name: heparan sulfate proteoglycan binding +namespace: molecular_function +def: "Interacting selectively with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "heparin proteoglycan binding" RELATED [] +is_a: GO:0043394 ! proteoglycan binding + +[Term] +id: GO:0043396 +name: corticotropin-releasing hormone secretion +namespace: biological_process +def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914] +synonym: "corticotropin-releasing factor secretion" EXACT [] +synonym: "CRF secretion" EXACT [] +synonym: "CRH secretion" EXACT [] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0043397 +name: regulation of corticotropin-releasing hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914] +synonym: "regulation of corticotropin-releasing factor secretion" EXACT [] +synonym: "regulation of CRF secretion" EXACT [] +synonym: "regulation of CRH secretion" EXACT [] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion + +[Term] +id: GO:0043398 +name: HLH domain binding +namespace: molecular_function +def: "Interacting selectively with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0043399 +name: tRNA A64-2'-O-ribosylphosphate transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, UniProtKB:P23796] +synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT [] +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0043400 +name: cortisol secretion +namespace: biological_process +def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0043401 +name: steroid hormone mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a steroid hormone." [PMID:12606724] +synonym: "steroid hormone mediated signalling" EXACT [] +is_a: GO:0009755 ! hormone-mediated signaling +is_a: GO:0048545 ! response to steroid hormone stimulus + +[Term] +id: GO:0043402 +name: glucocorticoid mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347] +synonym: "glucocorticoid mediated signalling" EXACT [] +is_a: GO:0043401 ! steroid hormone mediated signaling +is_a: GO:0051384 ! response to glucocorticoid stimulus + +[Term] +id: GO:0043403 +name: skeletal muscle regeneration +namespace: biological_process +def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119] +synonym: "myofiber turnover" RELATED [] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0043404 +name: corticotropin-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with corticotropin-releasing hormone to initiate a change in cell activity." [ISBN:0838577016, PMID:11027914, PMID:15134857] +is_a: GO:0004872 ! receptor activity +is_a: GO:0051424 ! corticotropin-releasing hormone binding + +[Term] +id: GO:0043405 +name: regulation of MAP kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] +synonym: "Regulation of MAPK activity" EXACT [GOC:dph] +synonym: "regulation of mitogen activated protein kinase activity" EXACT [] +synonym: "regulation of mitogen-activated protein kinase activity" EXACT [] +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0043406 +name: positive regulation of MAP kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] +synonym: "positive regulation of mitogen activated protein kinase activity" EXACT [] +synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT [] +synonym: "stimulation of MAPK activity" NARROW [] +synonym: "up regulation of MAPK activity" EXACT [] +synonym: "up-regulation of MAPK activity" EXACT [] +synonym: "upregulation of MAPK activity" EXACT [] +is_a: GO:0043405 ! regulation of MAP kinase activity +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0043407 +name: negative regulation of MAP kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] +synonym: "down regulation of MAPK activity" EXACT [] +synonym: "down-regulation of MAPK activity" EXACT [] +synonym: "downregulation of MAPK activity" EXACT [] +synonym: "inhibition of MAPK activity" NARROW [] +synonym: "negative regulation of mitogen activated protein kinase activity" EXACT [] +synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0043405 ! regulation of MAP kinase activity + +[Term] +id: GO:0043408 +name: regulation of MAPKKK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] +synonym: "regulation of MAP kinase kinase kinase cascade" EXACT [] +synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] +synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: regulates GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0043409 +name: negative regulation of MAPKKK cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] +synonym: "down regulation of MAPKKK cascade" EXACT [] +synonym: "down-regulation of MAPKKK cascade" EXACT [] +synonym: "downregulation of MAPKKK cascade" EXACT [] +synonym: "inhibition of MAPKKK cascade" NARROW [] +synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT [] +synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] +synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] +is_a: GO:0010741 ! negative regulation of protein kinase cascade +is_a: GO:0043408 ! regulation of MAPKKK cascade +relationship: negatively_regulates GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0043410 +name: positive regulation of MAPKKK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] +synonym: "activation of MAPKKK cascade" NARROW [] +synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT [] +synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] +synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] +synonym: "stimulation of MAPKKK cascade" NARROW [] +synonym: "up regulation of MAPKKK cascade" EXACT [] +synonym: "up-regulation of MAPKKK cascade" EXACT [] +synonym: "upregulation of MAPKKK cascade" EXACT [] +is_a: GO:0010740 ! positive regulation of protein kinase cascade +is_a: GO:0043408 ! regulation of MAPKKK cascade +relationship: positively_regulates GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0043411 +name: myopalladin binding +namespace: molecular_function +def: "Interacting selectively with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0043412 +name: biopolymer modification +namespace: biological_process +def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043283 ! biopolymer metabolic process + +[Term] +id: GO:0043413 +name: biopolymer glycosylation +namespace: biological_process +def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer." [GOC:jl] +subset: gosubset_prok +is_a: GO:0043412 ! biopolymer modification +is_a: GO:0070085 ! glycosylation + +[Term] +id: GO:0043414 +name: biopolymer methylation +namespace: biological_process +def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0032259 ! methylation +is_a: GO:0043412 ! biopolymer modification + +[Term] +id: GO:0043415 +name: positive regulation of skeletal muscle regeneration +namespace: biological_process +def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl] +synonym: "activation of skeletal muscle regeneration" NARROW [] +synonym: "stimulation of skeletal muscle regeneration" NARROW [] +synonym: "up regulation of skeletal muscle regeneration" EXACT [] +synonym: "up-regulation of skeletal muscle regeneration" EXACT [] +synonym: "upregulation of skeletal muscle regeneration" EXACT [] +is_a: GO:0043416 ! regulation of skeletal muscle regeneration +is_a: GO:0048639 ! positive regulation of developmental growth +relationship: positively_regulates GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0043416 +name: regulation of skeletal muscle regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0043417 +name: negative regulation of skeletal muscle regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl] +synonym: "down regulation of skeletal muscle regeneration" EXACT [] +synonym: "down-regulation of skeletal muscle regeneration" EXACT [] +synonym: "downregulation of skeletal muscle regeneration" EXACT [] +synonym: "inhibition of skeletal muscle regeneration" NARROW [] +is_a: GO:0043416 ! regulation of skeletal muscle regeneration +is_a: GO:0048640 ! negative regulation of developmental growth +relationship: negatively_regulates GO:0043403 ! skeletal muscle regeneration + +[Term] +id: GO:0043418 +name: homocysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl] +synonym: "homocysteine breakdown" EXACT [] +synonym: "homocysteine catabolism" EXACT [] +synonym: "homocysteine degradation" EXACT [] +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0043419 +name: urea catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl] +synonym: "urea breakdown" EXACT [] +synonym: "urea catabolism" EXACT [] +synonym: "urea decomposition" EXACT [] +synonym: "urea degradation" EXACT [] +is_a: GO:0019627 ! urea metabolic process +is_a: GO:0043605 ! amide catabolic process + +[Term] +id: GO:0043420 +name: anthranilate metabolic process +namespace: biological_process +alt_id: GO:0018869 +def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [ChEBI:16567, GOC:jl] +synonym: "2-aminobenzoate metabolic process" EXACT [] +synonym: "2-aminobenzoate metabolism" EXACT [] +synonym: "anthranilate metabolism" EXACT [] +synonym: "anthranilic acid metabolic process" NARROW [] +synonym: "anthranilic acid metabolism" NARROW [] +synonym: "ortho-aminobenzoic acid metabolic process" NARROW [] +synonym: "ortho-aminobenzoic acid metabolism" NARROW [] +xref: UM-BBD_pathwayID:abz2 +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0018874 ! benzoate metabolic process + +[Term] +id: GO:0043421 +name: anthranilate catabolic process +namespace: biological_process +alt_id: GO:0019259 +def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [ChEBI:16567, GOC:jl] +synonym: "2-aminobenzoate breakdown" EXACT [] +synonym: "2-aminobenzoate catabolic process" NARROW [] +synonym: "2-aminobenzoate catabolism" NARROW [] +synonym: "2-aminobenzoate degradation" EXACT [] +synonym: "anthranilate breakdown" EXACT [] +synonym: "anthranilate catabolism" EXACT [] +synonym: "anthranilate degradation" EXACT [] +synonym: "anthranilic acid catabolic process" NARROW [] +synonym: "anthranilic acid catabolism" NARROW [] +synonym: "ortho-aminobenzoic acid catabolic process" NARROW [] +synonym: "ortho-aminobenzoic acid catabolism" NARROW [] +xref: MetaCyc:2AMINOBENZDEG-PWY +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043420 ! anthranilate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0043422 +name: protein kinase B binding +namespace: molecular_function +def: "Interacting selectively with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/] +synonym: "Akt binding" EXACT [] +synonym: "PKB binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0043423 +name: 3-phosphoinositide-dependent protein kinase binding +namespace: molecular_function +def: "Interacting selectively with a 3-phosphoinositide-dependent protein kinase." [GOC:jl] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0043424 +name: protein histidine kinase binding +namespace: molecular_function +def: "Interacting selectively with protein histidine kinase." [GOC:jl] +synonym: "histidine kinase binding" EXACT [] +synonym: "histidine-protein kinase binding" EXACT [] +synonym: "protein-histidine kinase binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0043425 +name: bHLH transcription factor binding +namespace: molecular_function +def: "Interacting selectively with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transciptional networks of many developmental pathways." [PMID:9144210] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0043426 +name: MRF binding +namespace: molecular_function +def: "Interacting selectively with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of trascription factors." [PMID:10966875] +is_a: GO:0043425 ! bHLH transcription factor binding + +[Term] +id: GO:0043427 +name: carbon fixation by 3-hydroxypropionate cycle +namespace: biological_process +def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028] +synonym: "3-hydroxypropionate cycle" EXACT [] +synonym: "3-hydroxypropionate pathway" EXACT [] +synonym: "hydroxypropionate cycle" EXACT [] +synonym: "hydroxypropionate pathway" EXACT [] +is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide + +[Term] +id: GO:0043428 +name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043429 +name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043430 +name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043431 +name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344] +synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT [] +synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT [] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0043433 +name: negative regulation of transcription factor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] +synonym: "down regulation of transcription factor activity" EXACT [] +synonym: "down-regulation of transcription factor activity" EXACT [] +synonym: "downregulation of transcription factor activity" EXACT [] +synonym: "inhibition of transcription factor activity" NARROW [] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:0051090 ! regulation of transcription factor activity + +[Term] +id: GO:0043434 +name: response to peptide hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [http://en.wikipedia.org/, PMID:11027914, PMID:15134857] +synonym: "response to polypeptide hormone stimulus" EXACT [] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0043435 +name: response to corticotropin-releasing hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [http://en.wikipedia.org/, PMID:11027914, PMID:15134857] +synonym: "response to corticoliberin stimulus" EXACT [] +synonym: "response to corticotropin-releasing factor stimulus" EXACT [] +synonym: "response to CRF stimulus" EXACT [] +synonym: "response to CRH stimulus" EXACT [] +is_a: GO:0043434 ! response to peptide hormone stimulus + +[Term] +id: GO:0043436 +name: oxoacid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any oxoacid, acids containing a ketone group (-CO-) in addition to the acid group(s)." [http://cancerweb.ncl.ac.uk/] +synonym: "keto acid metabolic process" EXACT [] +synonym: "keto acid metabolism" EXACT [] +synonym: "ketoacid metabolic process" EXACT [] +synonym: "ketoacid metabolism" EXACT [] +synonym: "oxo acid metabolic process" EXACT [] +synonym: "oxo acid metabolism" EXACT [] +synonym: "oxoacid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0043437 +name: butanoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any butanoic acid, 4-carbon saturated monocarboxylic acids." [http://cancerweb.ncl.ac.uk/] +synonym: "butanoic acid metabolism" EXACT [] +synonym: "butyric acid metabolic process" EXACT [] +synonym: "butyric acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0043438 +name: acetoacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [http://en.wikipedia.org/] +synonym: "3-oxobutanoate metabolic process" EXACT [] +synonym: "3-oxobutanoate metabolism" EXACT [] +synonym: "3-oxobutanoic acid metabolic process" EXACT [] +synonym: "3-oxobutanoic acid metabolism" EXACT [] +synonym: "acetoacetate metabolic process" EXACT [] +synonym: "acetoacetate metabolism" EXACT [] +synonym: "acetoacetic acid metabolism" EXACT [] +synonym: "beta ketobutyric acid metabolic process" EXACT [] +synonym: "beta ketobutyric acid metabolism" EXACT [] +synonym: "beta-ketobutyric acid metabolic process" EXACT [] +synonym: "beta-ketobutyric acid metabolism" EXACT [] +synonym: "diacetic acid metabolic process" EXACT [] +synonym: "diacetic acid metabolism" EXACT [] +is_a: GO:0043437 ! butanoic acid metabolic process + +[Term] +id: GO:0043439 +name: butanoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any butanoic acid, 4-carbon saturated monocarboxylic acids." [GOC:jl] +synonym: "butanoic acid anabolism" EXACT [] +synonym: "butanoic acid biosynthesis" EXACT [] +synonym: "butanoic acid formation" EXACT [] +synonym: "butanoic acid synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0043437 ! butanoic acid metabolic process + +[Term] +id: GO:0043440 +name: butanoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any butanoic acid, 4-carbon saturated monocarboxylic acids." [GOC:jl] +synonym: "butanoic acid breakdown" EXACT [] +synonym: "butanoic acid catabolism" EXACT [] +synonym: "butanoic acid degradation" EXACT [] +is_a: GO:0019626 ! short-chain fatty acid catabolic process +is_a: GO:0043437 ! butanoic acid metabolic process + +[Term] +id: GO:0043441 +name: acetoacetic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] +synonym: "acetoacetic acid anabolism" EXACT [] +synonym: "acetoacetic acid biosynthesis" EXACT [] +synonym: "acetoacetic acid formation" EXACT [] +synonym: "acetoacetic acid synthesis" EXACT [] +is_a: GO:0043438 ! acetoacetic acid metabolic process +is_a: GO:0043439 ! butanoic acid biosynthetic process + +[Term] +id: GO:0043442 +name: acetoacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] +synonym: "acetoacetic acid breakdown" EXACT [] +synonym: "acetoacetic acid catabolism" EXACT [] +synonym: "acetoacetic acid degradation" EXACT [] +is_a: GO:0043438 ! acetoacetic acid metabolic process +is_a: GO:0043440 ! butanoic acid catabolic process + +[Term] +id: GO:0043443 +name: acetone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl] +synonym: "2-propanone metabolic process" EXACT [] +synonym: "2-propanone metabolism" EXACT [] +synonym: "acetone metabolism" EXACT [] +synonym: "dimethyl ketone metabolic process" EXACT [] +synonym: "dimethyl ketone metabolism" EXACT [] +synonym: "propan-2-one metabolic process" EXACT [] +synonym: "propan-2-one metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0043444 +name: acetone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl] +synonym: "2-propanone catabolic process" EXACT [] +synonym: "2-propanone catabolism" EXACT [] +synonym: "acetone breakdown" EXACT [] +synonym: "acetone catabolism" EXACT [] +synonym: "acetone degradation" EXACT [] +synonym: "dimethyl ketone catabolic process" EXACT [] +synonym: "dimethyl ketone catabolism" EXACT [] +synonym: "propan-2-one catabolic process" EXACT [] +synonym: "propan-2-one catabolism" EXACT [] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0043443 ! acetone metabolic process + +[Term] +id: GO:0043445 +name: acetone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl] +synonym: "2-propanone biosynthesis" EXACT [] +synonym: "2-propanone biosynthetic process" EXACT [] +synonym: "acetone anabolism" EXACT [] +synonym: "acetone biosynthesis" EXACT [] +synonym: "acetone formation" EXACT [] +synonym: "acetone synthesis" EXACT [] +synonym: "dimethyl ketone biosynthesis" EXACT [] +synonym: "dimethyl ketone biosynthetic process" EXACT [] +synonym: "propan-2-one biosynthesis" EXACT [] +synonym: "propan-2-one biosynthetic process" EXACT [] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043443 ! acetone metabolic process + +[Term] +id: GO:0043446 +name: cellular alkane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alkane, any saturated hydrocarbon without cycles, as carried out by individual cells." [GOC:jl, http://en.wikipedia.org/] +subset: goslim_pir +subset: gosubset_prok +synonym: "alkane metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0043447 +name: alkane biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alkane, any saturated hydrocarbon without cycles." [GOC:jl, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "alkane anabolism" EXACT [] +synonym: "alkane biosynthesis" EXACT [] +synonym: "alkane formation" EXACT [] +synonym: "alkane synthesis" EXACT [] +is_a: GO:0043446 ! cellular alkane metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0043448 +name: alkane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any saturated hydrocarbon without cycles." [GOC:jl, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "alkane breakdown" EXACT [] +synonym: "alkane catabolism" EXACT [] +synonym: "alkane degradation" EXACT [] +is_a: GO:0043446 ! cellular alkane metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0043449 +name: cellular alkene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond, as carried out by individual cells." [GOC:jl, http://en.wikipedia.org/] +subset: goslim_pir +subset: gosubset_prok +synonym: "alkene metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0043450 +name: alkene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond." [GOC:jl, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "alkene anabolism" EXACT [] +synonym: "alkene biosynthesis" EXACT [] +synonym: "alkene formation" EXACT [] +synonym: "alkene synthesis" EXACT [] +is_a: GO:0043449 ! cellular alkene metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0043451 +name: alkene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alkene, unsaturated hydrocarbons containing at least one carbon-carbon double bond." [GOC:jl, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "alkene breakdown" EXACT [] +synonym: "alkene catabolism" EXACT [] +synonym: "alkene degradation" EXACT [] +is_a: GO:0043449 ! cellular alkene metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0043452 +name: cellular alkyne metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms, as carried out by individual cells." [GOC:jl, http://en.wikipedia.org/] +subset: goslim_pir +subset: gosubset_prok +synonym: "alkyne metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0043453 +name: alkyne biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms." [GOC:jl, http://en.wikipedia.org/] +synonym: "alkyne anabolism" EXACT [] +synonym: "alkyne biosynthesis" EXACT [] +synonym: "alkyne formation" EXACT [] +synonym: "alkyne synthesis" EXACT [] +is_a: GO:0043452 ! cellular alkyne metabolic process + +[Term] +id: GO:0043454 +name: alkyne catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any hydrocarbon that has at least one triple bond between two carbon atoms." [GOC:jl, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "alkyne breakdown" EXACT [] +synonym: "alkyne catabolism" EXACT [] +synonym: "alkyne degradation" EXACT [] +is_a: GO:0043452 ! cellular alkyne metabolic process + +[Term] +id: GO:0043455 +name: regulation of secondary metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] +synonym: "regulation of secondary metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0043456 +name: regulation of pentose-phosphate shunt +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process by which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl] +synonym: "regulation of pentose phosphate pathway" EXACT [] +synonym: "regulation of pentose phosphate shunt" EXACT [] +synonym: "regulation of pentose-phosphate pathway" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: regulates GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:0043457 +name: regulation of cellular respiration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl] +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0045333 ! cellular respiration + +[Term] +id: GO:0043458 +name: ethanol biosynthetic process during fermentation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, during the process of fermentation." [GOC:jl] +synonym: "ethanol anabolism during fermentation" EXACT [] +synonym: "ethanol formation during fermentation" EXACT [] +synonym: "ethanol synthesis during fermentation" EXACT [] +is_a: GO:0006115 ! ethanol biosynthetic process +relationship: part_of GO:0019655 ! glucose catabolic process to ethanol + +[Term] +id: GO:0043459 +name: response to short exposure to lithium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444] +is_a: GO:0010226 ! response to lithium ion + +[Term] +id: GO:0043460 +name: response to long exposure to lithium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444] +is_a: GO:0010226 ! response to lithium ion + +[Term] +id: GO:0043461 +name: proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/] +subset: gosubset_prok +synonym: "F-type ATPase complex assembly" EXACT [] +is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly + +[Term] +id: GO:0043462 +name: regulation of ATPase activity +namespace: biological_process +def: "Any process that modulates the rate of ATP hydrolysis by an ATPase." [GOC:jl] +synonym: "regulation of adenosinetriphosphatase activity" EXACT [] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0043463 +name: regulation of rhamnose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl] +synonym: "regulation of rhamnose breakdown" EXACT [] +synonym: "regulation of rhamnose catabolism" EXACT [] +synonym: "regulation of rhamnose degradation" EXACT [] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0019301 ! rhamnose catabolic process + +[Term] +id: GO:0043464 +name: malolactic fermentation +namespace: biological_process +def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948] +synonym: "L-malate fermentation" BROAD [] +synonym: "malate fermentation" BROAD [] +synonym: "malo-lactate fermentation" EXACT [] +synonym: "malolactate fermentation" EXACT [] +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0043465 +name: regulation of fermentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl] +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0006113 ! fermentation + +[Term] +id: GO:0043466 +name: pyrimidine fermentation +namespace: biological_process +def: "The anaerobic conversion of pyrimidines, yielding energy in the form of ATP." [GOC:jl] +is_a: GO:0006208 ! pyrimidine base catabolic process +is_a: GO:0019666 ! nitrogenous compound catabolic process + +[Term] +id: GO:0043467 +name: regulation of generation of precursor metabolites and energy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0043468 +name: regulation of fucose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0019317 ! fucose catabolic process + +[Term] +id: GO:0043469 +name: regulation of D-xylose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0042843 ! D-xylose catabolic process + +[Term] +id: GO:0043470 +name: regulation of carbohydrate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009894 ! regulation of catabolic process +relationship: regulates GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0043471 +name: regulation of cellular carbohydrate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0043472 +name: IgD binding +namespace: molecular_function +def: "Interacting selectively with an immunoglobulin of a D isotype." [PMID:12886015] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0043473 +name: pigmentation +namespace: biological_process +def: "The deposition or aggregation of coloring matter in an organism, tissue or cell." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0043474 +name: pigment metabolic process during pigmentation +namespace: biological_process +def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, occurring during the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:jl] +synonym: "pigment metabolism during pigmentation" EXACT [] +is_a: GO:0042440 ! pigment metabolic process +relationship: part_of GO:0043473 ! pigmentation + +[Term] +id: GO:0043475 +name: pigment metabolic process during pigment accumulation +namespace: biological_process +def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, occurring during pigment accumulation." [GOC:jl] +synonym: "pigment metabolism during pigment accumulation" EXACT [] +is_a: GO:0043474 ! pigment metabolic process during pigmentation +relationship: part_of GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043476 +name: pigment accumulation +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] +synonym: "pigment accumulation in response to external stimulus" EXACT [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0043477 +name: pigment biosynthetic process during pigment accumulation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, occurring during pigment accumulation." [GOC:jl] +is_a: GO:0043475 ! pigment metabolic process during pigment accumulation +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0043478 +name: pigment accumulation in response to UV light +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl] +is_a: GO:0009411 ! response to UV +is_a: GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043479 +name: pigment accumulation in tissues in response to UV light +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] +is_a: GO:0043478 ! pigment accumulation in response to UV light +is_a: GO:0043480 ! pigment accumulation in tissues + +[Term] +id: GO:0043480 +name: pigment accumulation in tissues +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl] +synonym: "organismal pigment accumulation" EXACT [] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043481 +name: anthocyanin accumulation in tissues in response to UV light +namespace: biological_process +def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] +is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light + +[Term] +id: GO:0043482 +name: cellular pigment accumulation +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl] +subset: gosubset_prok +is_a: GO:0033059 ! cellular pigmentation +is_a: GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043483 +name: anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, occurring during anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:jl] +synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" EXACT [] +synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" EXACT [] +is_a: GO:0009718 ! anthocyanin biosynthetic process +is_a: GO:0043477 ! pigment biosynthetic process during pigment accumulation +relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light + +[Term] +id: GO:0043484 +name: regulation of RNA splicing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0008380 ! RNA splicing + +[Term] +id: GO:0043485 +name: endosome to pigment granule transport +namespace: biological_process +def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl] +is_a: GO:0016197 ! endosome transport +relationship: part_of GO:0048757 ! pigment granule maturation + +[Term] +id: GO:0043486 +name: histone exchange +namespace: biological_process +def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] +comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization. +synonym: "histone displacement" EXACT [] +synonym: "histone replacement" EXACT [] +is_a: GO:0034728 ! nucleosome organization +is_a: GO:0043044 ! ATP-dependent chromatin remodeling + +[Term] +id: GO:0043487 +name: regulation of RNA stability +namespace: biological_process +def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] +subset: gosubset_prok +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0051252 ! regulation of RNA metabolic process + +[Term] +id: GO:0043488 +name: regulation of mRNA stability +namespace: biological_process +def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] +subset: gosubset_prok +is_a: GO:0016071 ! mRNA metabolic process +is_a: GO:0043487 ! regulation of RNA stability + +[Term] +id: GO:0043489 +name: RNA stabilization +namespace: biological_process +def: "Prevention of degradation of RNA molecules." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0043487 ! regulation of RNA stability + +[Term] +id: GO:0043490 +name: malate-aspartate shuttle +namespace: biological_process +def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/] +synonym: "malate aspartate shuttle" EXACT [] +synonym: "malate/aspartate shuttle" EXACT [] +synonym: "malate:aspartate shuttle" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +relationship: part_of GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0043491 +name: protein kinase B signaling cascade +namespace: biological_process +def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound." [GOC:bf] +synonym: "AKT signaling cascade" EXACT [] +synonym: "AKT signalling cascade" EXACT [] +synonym: "PKB signaling cascade" EXACT [] +synonym: "PKB signalling cascade" EXACT [] +synonym: "protein kinase B signalling cascade" EXACT [] +is_a: GO:0007243 ! protein kinase cascade + +[Term] +id: GO:0043492 +name: ATPase activity, coupled to movement of substances +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042623 ! ATPase activity, coupled + +[Term] +id: GO:0043493 +name: phage terminase complex +namespace: cellular_component +def: "A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides." [GOC:mlg] +is_a: GO:0033655 ! host cell cytoplasm part +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0043494 +name: Rik1-E3 ubiquitin ligase complex +namespace: cellular_component +def: "A protein complex that consists of (minimally) cullin, RING finger, methyltransferase, Rik1 WD repeat protein, Raf1 and Raf2. Required to regulate heterchromatin formation by RNAi and for histone H3K9 methylation." [GOC:jl, PMID:16024659, PMID:16040243] +synonym: "Rik1 E3 ubiquitin ligase complex" EXACT [] +is_a: GO:0031465 ! Cul4B-RING ubiquitin ligase complex + +[Term] +id: GO:0043495 +name: protein anchor +namespace: molecular_function +def: "Interacting selectively with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [GOC:go_curators] +synonym: "anchoring" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043496 +name: regulation of protein homodimerization activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb] +comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'. +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0043497 +name: regulation of protein heterodimerization activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb] +comment: Note that protein heterodimerization is a molecular function: 'protein heterodimerization activity ; GO:0046982'. +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0043498 +name: cell surface binding +namespace: molecular_function +def: "Interacting selectively with any component on the surface of a cell." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043499 +name: eukaryotic cell surface binding +namespace: molecular_function +def: "Interacting selectively with any component on the surface of a eukaryotic cell." [GOC:jl] +is_a: GO:0043498 ! cell surface binding + +[Term] +id: GO:0043500 +name: muscle adaptation +namespace: biological_process +def: "A process by which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] +subset: goslim_pir +synonym: "muscle plasticity" RELATED [] +is_a: GO:0003012 ! muscle system process + +[Term] +id: GO:0043501 +name: skeletal muscle adaptation +namespace: biological_process +def: "Any process by which skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] +synonym: "skeletal muscle plasticity" RELATED [] +is_a: GO:0014888 ! striated muscle adaptation + +[Term] +id: GO:0043502 +name: regulation of muscle adaptation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] +synonym: "regulation of muscle plasticity" RELATED [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0043500 ! muscle adaptation + +[Term] +id: GO:0043503 +name: skeletal muscle fiber adaptation +namespace: biological_process +def: "Any process by which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibres are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] +synonym: "skeletal muscle fiber plasticity" RELATED [] +synonym: "skeletal muscle fibre plasticity" EXACT [] +synonym: "skeletal myofiber plasticity" EXACT [] +synonym: "skeletal myofibre plasticity" EXACT [] +is_a: GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0043504 +name: mitochondrial DNA repair +namespace: biological_process +def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976] +is_a: GO:0006281 ! DNA repair +is_a: GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:0043505 +name: centromere-specific nucleosome +namespace: cellular_component +def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641] +synonym: "centromere specific nucleosome" EXACT [] +synonym: "centromeric nucleosome" EXACT [] +is_a: GO:0000786 ! nucleosome +relationship: part_of GO:0000939 ! inner kinetochore of condensed chromosome + +[Term] +id: GO:0043506 +name: regulation of JNK activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl] +synonym: "regulation of JUN kinase activity" EXACT [] +synonym: "regulation of JUNK activity" EXACT [] +is_a: GO:0043405 ! regulation of MAP kinase activity + +[Term] +id: GO:0043507 +name: positive regulation of JNK activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl] +synonym: "positive regulation of JUN kinase activity" EXACT [] +synonym: "positive regulation of JUNK activity" EXACT [] +synonym: "stimulation of JNK activity" NARROW [] +synonym: "up regulation of JNK activity" EXACT [] +synonym: "up-regulation of JNK activity" EXACT [] +synonym: "upregulation of JNK activity" EXACT [] +is_a: GO:0043406 ! positive regulation of MAP kinase activity +is_a: GO:0043506 ! regulation of JNK activity + +[Term] +id: GO:0043508 +name: negative regulation of JNK activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl] +synonym: "down regulation of JNK activity" EXACT [] +synonym: "down-regulation of JNK activity" EXACT [] +synonym: "downregulation of JNK activity" EXACT [] +synonym: "inhibition of JNK activity" NARROW [] +synonym: "negative regulation of JUN kinase activity" EXACT [] +synonym: "negative regulation of JUNK activity" EXACT [] +is_a: GO:0043407 ! negative regulation of MAP kinase activity +is_a: GO:0043506 ! regulation of JNK activity + +[Term] +id: GO:0043509 +name: activin A complex +namespace: cellular_component +alt_id: GO:0048181 +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'. +is_a: GO:0048180 ! activin complex + +[Term] +id: GO:0043510 +name: activin B complex +namespace: cellular_component +alt_id: GO:0048182 +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. +is_a: GO:0048180 ! activin complex + +[Term] +id: GO:0043511 +name: inhibin complex +namespace: cellular_component +def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl] +comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0043512 +name: inhibin A complex +namespace: cellular_component +def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl] +comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. +is_a: GO:0043511 ! inhibin complex + +[Term] +id: GO:0043513 +name: inhibin B complex +namespace: cellular_component +def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl] +comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. +is_a: GO:0043511 ! inhibin complex + +[Term] +id: GO:0043514 +name: interleukin-12 complex +namespace: cellular_component +def: "A protein complex that is composed of an interleukin-12 alpha and an interleukin-12 beta subunit and is secreted into the extracellular space." [GOC:ebc, GOC:mah] +synonym: "IL-12 complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0043515 +name: kinetochore binding +namespace: molecular_function +def: "Interacting selectively with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043516 +name: regulation of DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] +synonym: "regulation of p53 induced by DNA damage response" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0043517 +name: positive regulation of DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] +synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW [] +synonym: "positive regulation of p53 induced by DNA damage response" EXACT [] +synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW [] +synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0043518 +name: negative regulation of DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] +synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW [] +synonym: "negative regulation of p53 induced by DNA damage response" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0043519 +name: regulation of myosin II filament assembly or disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0031038 ! myosin II filament assembly or disassembly + +[Term] +id: GO:0043520 +name: regulation of myosin II filament assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl] +is_a: GO:0043254 ! regulation of protein complex assembly +is_a: GO:0043519 ! regulation of myosin II filament assembly or disassembly +relationship: regulates GO:0031036 ! myosin II filament assembly + +[Term] +id: GO:0043521 +name: regulation of myosin II filament disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] +is_a: GO:0043244 ! regulation of protein complex disassembly +is_a: GO:0043519 ! regulation of myosin II filament assembly or disassembly +relationship: regulates GO:0031037 ! myosin II filament disassembly + +[Term] +id: GO:0043522 +name: leucine zipper domain binding +namespace: molecular_function +def: "Interacting selectively with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158] +synonym: "leucine zipper binding" EXACT [] +is_a: GO:0030275 ! LRR domain binding + +[Term] +id: GO:0043523 +name: regulation of neuron apoptosis +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptosis in neurons." [GOC:go_curators] +synonym: "regulation of apoptosis of neuronal cells" EXACT [] +synonym: "regulation of apoptosis of neurons" EXACT [] +synonym: "regulation of neuron programmed cell death" EXACT [] +synonym: "regulation of neuronal cell programmed cell death" EXACT [] +synonym: "regulation of programmed cell death of neuronal cells" EXACT [] +synonym: "regulation of programmed cell death, neurons" EXACT [] +is_a: GO:0042981 ! regulation of apoptosis +relationship: regulates GO:0051402 ! neuron apoptosis + +[Term] +id: GO:0043524 +name: negative regulation of neuron apoptosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis in neurons." [GOC:go_curators] +synonym: "down regulation of neuron apoptosis" EXACT [] +synonym: "down-regulation of neuron apoptosis" EXACT [] +synonym: "downregulation of neuron apoptosis" EXACT [] +synonym: "inhibition of neuron apoptosis" NARROW [] +synonym: "negative regulation of programmed cell death, neurons" EXACT [] +synonym: "neuron survival" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptosis +is_a: GO:0043523 ! regulation of neuron apoptosis +relationship: negatively_regulates GO:0051402 ! neuron apoptosis + +[Term] +id: GO:0043525 +name: positive regulation of neuron apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptosis." [GOC:go_curators] +synonym: "activation of neuron apoptosis" NARROW [] +synonym: "positive regulation of programmed cell death, neurons" EXACT [] +synonym: "stimulation of neuron apoptosis" NARROW [] +synonym: "up regulation of neuron apoptosis" EXACT [] +synonym: "up-regulation of neuron apoptosis" EXACT [] +synonym: "upregulation of neuron apoptosis" EXACT [] +is_a: GO:0043065 ! positive regulation of apoptosis +is_a: GO:0043523 ! regulation of neuron apoptosis +relationship: positively_regulates GO:0051402 ! neuron apoptosis + +[Term] +id: GO:0043526 +name: neuroprotection +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [MeSH:G04.335.139.160, PMID:10208444, PMID:11909981, PMID:15905876] +is_a: GO:0043523 ! regulation of neuron apoptosis + +[Term] +id: GO:0043527 +name: tRNA methyltransferase complex +namespace: cellular_component +def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0043528 +name: tRNA (m2G10) methyltransferase complex +namespace: cellular_component +def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842] +is_a: GO:0043527 ! tRNA methyltransferase complex + +[Term] +id: GO:0043529 +name: GET complex +namespace: cellular_component +def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340] +synonym: "Golgi to ER Traffic complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044432 ! endoplasmic reticulum part + +[Term] +id: GO:0043530 +name: adenosine 5'-monophosphoramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP-NH2 (adenosine 5'-monophosphoramidate) = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111] +synonym: "adenosine 5' monophosphoramidase activity" EXACT [] +synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT [] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043531 +name: ADP binding +namespace: molecular_function +def: "Interacting selectively with ADP, adenosine 5'-diphosphate." [GOC:jl] +synonym: "adenosine 5'-diphosphate binding" EXACT [] +synonym: "adenosine diphosphate binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding + +[Term] +id: GO:0043532 +name: angiostatin binding +namespace: molecular_function +def: "Interacting selectively with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043533 +name: inositol 1,3,4,5 tetrakisphosphate binding +namespace: molecular_function +def: "Interacting selectively with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "InsP4 binding" EXACT [] +synonym: "IP4 binding" EXACT [] +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0043534 +name: blood vessel endothelial cell migration +namespace: biological_process +def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264] +is_a: GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0043535 +name: regulation of blood vessel endothelial cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] +is_a: GO:0010594 ! regulation of endothelial cell migration +relationship: regulates GO:0043534 ! blood vessel endothelial cell migration + +[Term] +id: GO:0043536 +name: positive regulation of blood vessel endothelial cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] +synonym: "activation of blood vessel endothelial cell migration" NARROW [] +synonym: "stimulation of blood vessel endothelial cell migration" NARROW [] +synonym: "up regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "up-regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "upregulation of blood vessel endothelial cell migration" EXACT [] +is_a: GO:0010595 ! positive regulation of endothelial cell migration +is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration +relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration + +[Term] +id: GO:0043537 +name: negative regulation of blood vessel endothelial cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] +synonym: "down regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "down-regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "downregulation of blood vessel endothelial cell migration" EXACT [] +synonym: "inhibition of blood vessel endothelial cell migration" NARROW [] +is_a: GO:0010596 ! negative regulation of endothelial cell migration +is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration +relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration + +[Term] +id: GO:0043538 +name: regulation of actin phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators] +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0031289 ! actin phosphorylation + +[Term] +id: GO:0043539 +name: protein serine/threonine kinase activator activity +namespace: molecular_function +def: "Increases the activity of a protein serine/threonine kinase." [GOC:go_curators] +synonym: "protein ser/thr kinase activator activity" EXACT [] +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0043540 +name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex +namespace: cellular_component +def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0043541 +name: UDP-N-acetylglucosamine transferase complex +namespace: cellular_component +def: "A heterooligomeric complex that in yeast is composed of a catalytic subunit, Alg13p, and an anchoring subunit, Alg14p. Catalyzes the second step of dolichyl-linked oligosaccharide synthesis of GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc." [PMID:15615718, PMID:16100110, PMID:16100113] +comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'. +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part +is_a: GO:0044432 ! endoplasmic reticulum part +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0043542 +name: endothelial cell migration +namespace: biological_process +def: "The orderly movement of endothelial cells into the extracellular matrix to form an endothelium." [GOC:go_curators] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0043543 +name: protein amino acid acylation +namespace: biological_process +def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0043544 +name: lipoamide binding +namespace: molecular_function +def: "Interacting selectively with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] +is_a: GO:0031405 ! lipoic acid binding + +[Term] +id: GO:0043545 +name: molybdopterin cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +subset: gosubset_prok +synonym: "Moco metabolic process" EXACT [] +synonym: "Moco metabolism" EXACT [] +synonym: "molybdopterin cofactor metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0043546 +name: molybdopterin cofactor binding +namespace: molecular_function +def: "Interacting selectively with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +synonym: "Moco binding" EXACT [] +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0043547 +name: positive regulation of GTPase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a GTPase." [GOC:jl] +synonym: "activation of GTPase activity" NARROW [] +synonym: "stimulation of GTPase activity" NARROW [] +synonym: "up regulation of GTPase activity" EXACT [] +synonym: "up-regulation of GTPase activity" EXACT [] +synonym: "upregulation of GTPase activity" EXACT [] +is_a: GO:0043087 ! regulation of GTPase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0043548 +name: phosphoinositide 3-kinase binding +namespace: molecular_function +def: "Interacting selectively with a phosphoinositide 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] +is_a: GO:0019900 ! kinase binding + +[Term] +id: GO:0043549 +name: regulation of kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] +subset: gosubset_prok +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0043550 +name: regulation of lipid kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] +subset: gosubset_prok +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0043551 +name: regulation of phosphoinositide 3-kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphoinositide 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf] +is_a: GO:0043550 ! regulation of lipid kinase activity + +[Term] +id: GO:0043552 +name: positive regulation of phosphoinositide 3-kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphoinositide 3-kinase activity." [GOC:bf] +synonym: "activation of phosphoinositide 3-kinase activity" NARROW [] +synonym: "stimulation of phosphoinositide 3-kinase activity" NARROW [] +synonym: "up regulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "up-regulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "upregulation of phosphoinositide 3-kinase activity" EXACT [] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:0043551 ! regulation of phosphoinositide 3-kinase activity + +[Term] +id: GO:0043553 +name: negative regulation of phosphoinositide 3-kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphoinositide 3-kinase activity." [GOC:bf] +synonym: "down regulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "down-regulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "downregulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "inhibition of phosphoinositide 3-kinase activity" NARROW [] +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:0043551 ! regulation of phosphoinositide 3-kinase activity + +[Term] +id: GO:0043554 +name: aerobic respiration, using arsenite as electron donor +namespace: biological_process +def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0043555 +name: regulation of translation in response to stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] +synonym: "translational stress response" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0043556 +name: regulation of translation in response to oxidative stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:0043555 ! regulation of translation in response to stress + +[Term] +id: GO:0043557 +name: regulation of translation in response to osmotic stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] +is_a: GO:0006970 ! response to osmotic stress +is_a: GO:0043555 ! regulation of translation in response to stress + +[Term] +id: GO:0043558 +name: regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0043555 ! regulation of translation in response to stress + +[Term] +id: GO:0043559 +name: insulin binding +namespace: molecular_function +def: "Interacting selectively with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0043560 +name: insulin receptor substrate binding +namespace: molecular_function +def: "Interacting selectively with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233] +synonym: "insulin receptor substrate [protein] binding" EXACT [] +synonym: "IRS [protein] binding" EXACT [] +synonym: "IRS binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043561 +name: regulation of translational initiation in response to osmotic stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb] +is_a: GO:0043557 ! regulation of translation in response to osmotic stress +is_a: GO:0043558 ! regulation of translational initiation in response to stress + +[Term] +id: GO:0043562 +name: cellular response to nitrogen levels +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl] +subset: gosubset_prok +is_a: GO:0031669 ! cellular response to nutrient levels + +[Term] +id: GO:0043563 +name: odorant transporter activity +namespace: molecular_function +def: "Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of, within or between cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0043564 +name: Ku70:Ku80 complex +namespace: cellular_component +def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983, UniProtKB:P12956] +synonym: "Ku70:Ku80 heterodimer" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0043565 +name: sequence-specific DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] +subset: gosubset_prok +synonym: "sequence specific DNA binding" EXACT [] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0043566 +name: structure-specific DNA binding +namespace: molecular_function +def: "Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl] +subset: gosubset_prok +synonym: "structure specific DNA binding" EXACT [] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0043567 +name: regulation of insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] +synonym: "regulation of IGF receptor signaling pathway" EXACT [] +synonym: "regulation of IGF receptor signalling pathway" EXACT [] +synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway + +[Term] +id: GO:0043568 +name: positive regulation of insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] +synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of IGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of IGF receptor signalling pathway" EXACT [] +synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT [] +synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway +relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway + +[Term] +id: GO:0043569 +name: negative regulation of insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] +synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of IGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of IGF receptor signalling pathway" EXACT [] +synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway + +[Term] +id: GO:0043570 +name: maintenance of DNA repeat elements +namespace: biological_process +def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0043571 +name: maintenance of CRISPR repeat elements +namespace: biological_process +def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354] +synonym: "CRISPR element metabolic process" RELATED [] +synonym: "CRISPR element metabolism" RELATED [] +synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT [] +is_a: GO:0043570 ! maintenance of DNA repeat elements + +[Term] +id: GO:0043572 +name: plastid fission +namespace: biological_process +def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl] +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0043573 +name: leucoplast fission +namespace: biological_process +def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl] +is_a: GO:0043572 ! plastid fission + +[Term] +id: GO:0043574 +name: peroxisomal transport +namespace: biological_process +def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0043575 +name: detection of osmotic stimulus +namespace: biological_process +def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl] +is_a: GO:0006970 ! response to osmotic stress +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0043576 +name: regulation of respiratory gaseous exchange +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007585 ! respiratory gaseous exchange + +[Term] +id: GO:0043577 +name: chemotropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0009606 ! tropism +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0043578 +name: nuclear matrix organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah] +synonym: "nuclear matrix organisation and biogenesis" EXACT [] +synonym: "nuclear matrix organization and biogenesis" EXACT [] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0043579 +name: elaioplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl] +synonym: "elaioplast organisation and biogenesis" EXACT [] +synonym: "elaioplast organization and biogenesis" EXACT [] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0043580 +name: periplasmic space organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah] +subset: gosubset_prok +synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043581 +name: mycelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium is the mass of hyphae that constitutes the vegetative part of a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0043582 +name: sporangium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a plant or fungal structure producing and containing spores." [GOC:jl, http://en.wikipedia.org/] +synonym: "sporangia development" EXACT [] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0043583 +name: ear development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] +synonym: "hearing organ development" EXACT [] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0043584 +name: nose development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] +synonym: "nasus development" EXACT [] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0043585 +name: nose morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the nose are generated and organized. Morphogenesis pertains to the creation of form. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/] +synonym: "nasus morphogenesis" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0043584 ! nose development + +[Term] +id: GO:0043586 +name: tongue development +namespace: biological_process +def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.mercksource.com/] +synonym: "glossa development" NARROW [] +synonym: "lingua development" NARROW [] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0043587 +name: tongue morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the tongue are generated and organized. Morphogenesis pertains to the creation of form. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.mercksource.com/] +synonym: "glossa morphogenesis" NARROW [] +synonym: "lingua morphogenesis" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0043586 ! tongue development + +[Term] +id: GO:0043588 +name: skin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, http://cancerweb.ncl.ac.uk/] +synonym: "animal skin development" EXACT [] +is_a: GO:0008544 ! epidermis development + +[Term] +id: GO:0043589 +name: skin morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the skin are generated and organized. Morphogenesis pertains to the creation of form. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, http://cancerweb.ncl.ac.uk/] +is_a: GO:0048730 ! epidermis morphogenesis +relationship: part_of GO:0043588 ! skin development + +[Term] +id: GO:0043590 +name: bacterial nucleoid +namespace: cellular_component +def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009295 ! nucleoid + +[Term] +id: GO:0043591 +name: endospore external encapsulating structure +namespace: cellular_component +def: "The structures that lie outside the inner membrane and surround the entire endospore." [GOC:go_curators] +subset: goslim_pir +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0043592 +name: exosporium +namespace: cellular_component +def: "The outer-most layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg] +subset: gosubset_prok +synonym: "epispore" RELATED [] +synonym: "exospore" RELATED [] +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043593 +name: endospore coat +namespace: cellular_component +def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043594 +name: outer endospore membrane +namespace: cellular_component +def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0019867 ! outer membrane +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043595 +name: endospore cortex +namespace: cellular_component +def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg] +subset: gosubset_prok +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043596 +name: nuclear replication fork +namespace: cellular_component +def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] +synonym: "replication fork (sensu Eukaryota)" EXACT [] +is_a: GO:0005657 ! replication fork +is_a: GO:0044454 ! nuclear chromosome part + +[Term] +id: GO:0043597 +name: cytoplasmic replication fork +namespace: cellular_component +def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] +synonym: "replication fork (sensu Bacteria and Archaea)" EXACT [] +is_a: GO:0005657 ! replication fork +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0000229 ! cytoplasmic chromosome + +[Term] +id: GO:0043598 +name: cytoplasmic DNA replication factor C complex +namespace: cellular_component +def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [GOC:mtg_sensu, PMID:14646196, PMID:16172520] +synonym: "DNA replication factor C complex (sensu Bacteria and Archaea)" EXACT [] +is_a: GO:0005663 ! DNA replication factor C complex +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0043600 ! cytoplasmic replisome + +[Term] +id: GO:0043599 +name: nuclear DNA replication factor C complex +namespace: cellular_component +def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842] +synonym: "DNA replication factor C complex (sensu Eukaryota)" EXACT [] +is_a: GO:0005663 ! DNA replication factor C complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0043600 +name: cytoplasmic replisome +namespace: cellular_component +def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu] +synonym: "replisome (sensu Bacteria and Archaea)" EXACT [] +is_a: GO:0030894 ! replisome +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0043597 ! cytoplasmic replication fork + +[Term] +id: GO:0043601 +name: nuclear replisome +namespace: cellular_component +def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] +synonym: "replisome (sensu Eukaryota)" EXACT [] +is_a: GO:0030894 ! replisome +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043596 ! nuclear replication fork + +[Term] +id: GO:0043602 +name: nitrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] +synonym: "nitrate disassimilation" EXACT [] +synonym: "nitrate dissimilation" EXACT [] +is_a: GO:0042126 ! nitrate metabolic process + +[Term] +id: GO:0043603 +name: cellular amide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [ChEBI:32988] +subset: goslim_pir +subset: gosubset_prok +synonym: "amide metabolism" EXACT [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0043604 +name: amide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988] +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0043605 +name: amide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988] +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0043606 +name: formamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] +synonym: "formamide metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0043607 +name: formamide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0043606 ! formamide metabolic process + +[Term] +id: GO:0043608 +name: formamide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/] +is_a: GO:0043605 ! amide catabolic process +is_a: GO:0043606 ! formamide metabolic process + +[Term] +id: GO:0043609 +name: regulation of carbon utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0015976 ! carbon utilization + +[Term] +id: GO:0043610 +name: regulation of carbohydrate utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009758 ! carbohydrate utilization + +[Term] +id: GO:0043611 +name: isoprene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl] +subset: gosubset_prok +synonym: "2-methyl-1,3-butadiene metabolic process" EXACT [] +synonym: "2-methyl-1,3-butadiene metabolism" EXACT [] +synonym: "hemiterpene metabolic process" EXACT [] +synonym: "hemiterpene metabolism" EXACT [] +synonym: "isoprene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0043612 +name: isoprene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl] +synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT [] +synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT [] +synonym: "hemiterpene biosynthesis" EXACT [] +synonym: "hemiterpene biosynthetic process" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0043611 ! isoprene metabolic process + +[Term] +id: GO:0043613 +name: isoprene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl] +synonym: "2-methyl-1,3-butadiene catabolic process" EXACT [] +synonym: "2-methyl-1,3-butadiene catabolism" EXACT [] +synonym: "hemiterpene catabolic process" EXACT [] +synonym: "hemiterpene catabolism" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0043611 ! isoprene metabolic process + +[Term] +id: GO:0043614 +name: multi-eIF complex +namespace: cellular_component +def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc] +synonym: "multifactor translation initiation factor (eIF) complex" EXACT [] +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0043615 +name: astrocyte cell migration +namespace: biological_process +def: "The orderly movement of astrocytes, class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators] +synonym: "astrocyte migration" EXACT [] +synonym: "astrocytic glial cell migration" EXACT [] +is_a: GO:0008347 ! glial cell migration + +[Term] +id: GO:0043616 +name: keratinocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0043617 +name: cellular response to sucrose starvation +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0043618 +name: regulation of transcription from RNA polymerase II promoter in response to stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0043620 ! regulation of transcription in response to stress + +[Term] +id: GO:0043619 +name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0043620 +name: regulation of transcription in response to stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0045449 ! regulation of transcription + +[Term] +id: GO:0043621 +name: protein self-association +namespace: molecular_function +def: "Interacting selectively with a domain within the same polypeptide." [GOC:jl] +synonym: "intramolecular protein binding" EXACT [] +synonym: "protein self association" EXACT [] +synonym: "protein self binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043622 +name: cortical microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] +synonym: "cortical microtubule cytoskeleton organization and biogenesis" EXACT [] +synonym: "cortical microtubule organisation and biogenesis" EXACT [] +synonym: "cortical microtubule organization and biogenesis" EXACT [] +is_a: GO:0030865 ! cortical cytoskeleton organization +is_a: GO:0031122 ! cytoplasmic microtubule organization + +[Term] +id: GO:0043623 +name: cellular protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl] +subset: gosubset_prok +is_a: GO:0006461 ! protein complex assembly +is_a: GO:0034622 ! cellular macromolecular complex assembly + +[Term] +id: GO:0043624 +name: cellular protein complex disassembly +namespace: biological_process +def: "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] +subset: gosubset_prok +is_a: GO:0034623 ! cellular macromolecular complex disassembly +is_a: GO:0043241 ! protein complex disassembly + +[Term] +id: GO:0043625 +name: delta DNA polymerase complex +namespace: cellular_component +alt_id: GO:0005659 +def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] +synonym: "delta-DNA polymerase complex" EXACT [] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0043626 +name: PCNA complex +namespace: cellular_component +def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735] +subset: gosubset_prok +synonym: "PCNA homotrimer" EXACT [] +synonym: "proliferating cell nuclear antigen complex" EXACT [] +synonym: "sliding clamp" BROAD [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0043627 +name: response to estrogen stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "response to oestrogen stimulus" EXACT [] +is_a: GO:0048545 ! response to steroid hormone stimulus + +[Term] +id: GO:0043628 +name: ncRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl] +synonym: "ncRNA 3' end processing" EXACT [] +is_a: GO:0031123 ! RNA 3'-end processing +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0043629 +name: ncRNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues (typically 15-70 in S. cerevisiae) at the 3' end of substrates that may include the following nuclear non-coding RNAs (ncRNA) from eukaryotes: nuclear ncRNA precursors (includes pre-RNA, snoRNA and snRNA that may be incorrectly processed and/or assembled with proteins), aberrant nuclear ncRNAs (such as hypomethylated tRNA and short 5S rRNA), misfolded nuclear ncRNAs and variant forms of ncRNAs. Serves as a prerequisite step for subsequent exosome-mediated degradation." [GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988] +synonym: "non-coding RNA polyadenylation" EXACT [] +is_a: GO:0043628 ! ncRNA 3'-end processing +is_a: GO:0043631 ! RNA polyadenylation + +[Term] +id: GO:0043630 +name: ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring during the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:jl] +is_a: GO:0043629 ! ncRNA polyadenylation +relationship: part_of GO:0043634 ! polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0043631 +name: RNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl] +subset: gosubset_prok +is_a: GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0043632 +name: modification-dependent macromolecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0043633 +name: modification-dependent RNA catabolic process +namespace: biological_process +def: "Destruction of an RNA molecule, initiated by the covalent modification of the target RNA." [GOC:jl] +is_a: GO:0006401 ! RNA catabolic process +is_a: GO:0043632 ! modification-dependent macromolecule catabolic process + +[Term] +id: GO:0043634 +name: polyadenylation-dependent ncRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target RNA." [GOC:jl] +is_a: GO:0043633 ! modification-dependent RNA catabolic process + +[Term] +id: GO:0043635 +name: methylnaphthalene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687] +synonym: "1-methylnaphthalene catabolic process" NARROW [] +synonym: "1-methylnaphthalene catabolism" NARROW [] +synonym: "1-MN catabolic process" RELATED [] +synonym: "1-MN catabolism" RELATED [] +synonym: "2-methylnaphthalene catabolic process" NARROW [] +synonym: "2-methylnaphthalene catabolism" NARROW [] +synonym: "2-MN catabolic process" RELATED [] +synonym: "2-MN catabolism" RELATED [] +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0043636 +name: bisphenol A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [GOC:jl, http://en.wikipedia.org/] +synonym: "bisphenol-A catabolic process" EXACT [] +synonym: "bisphenol-A catabolism" EXACT [] +is_a: GO:0019336 ! phenol catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0043637 +name: puromycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, http://en.wikipedia.org/, PMID:8226694] +subset: gosubset_prok +synonym: "puromycin metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0016999 ! antibiotic metabolic process + +[Term] +id: GO:0043638 +name: puromycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, http://en.wikipedia.org/] +subset: gosubset_prok +is_a: GO:0009163 ! nucleoside biosynthetic process +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0043637 ! puromycin metabolic process + +[Term] +id: GO:0043639 +name: benzoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl] +subset: gosubset_prok +synonym: "benzoate breakdown" EXACT [] +synonym: "benzoate catabolism" EXACT [] +synonym: "benzoate degradation" EXACT [] +is_a: GO:0018874 ! benzoate metabolic process + +[Term] +id: GO:0043640 +name: benzoate catabolic process via hydroxylation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503] +synonym: "benzoate breakdown via hydroxylation" EXACT [] +synonym: "benzoate degradation via hydroxylation" EXACT [] +xref: MetaCyc:PWY-2503 +is_a: GO:0043639 ! benzoate catabolic process + +[Term] +id: GO:0043641 +name: novobiocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "novobiocin metabolism" EXACT [] +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0016999 ! antibiotic metabolic process + +[Term] +id: GO:0043642 +name: novobiocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://en.wikipedia.org/] +subset: gosubset_prok +is_a: GO:0009805 ! coumarin biosynthetic process +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0043641 ! novobiocin metabolic process + +[Term] +id: GO:0043643 +name: tetracycline metabolic process +namespace: biological_process +def: "The chemical reactions involving tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "tetracyclin metabolic process" EXACT [] +synonym: "tetracyclin metabolism" EXACT [] +synonym: "tetracycline metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0043644 +name: tetracycline biosynthetic process +namespace: biological_process +def: "The formation from simpler components of tetracycline, a broad spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "tetracyclin biosynthesis" EXACT [] +synonym: "tetracyclin biosynthetic process" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043643 ! tetracycline metabolic process + +[Term] +id: GO:0043645 +name: cephalosporin metabolic process +namespace: biological_process +def: "The chemical reactions involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://en.wikipedia.org/] +subset: gosubset_prok +synonym: "cephalosporin metabolism" EXACT [] +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0043646 +name: cephalosporin biosynthetic process +namespace: biological_process +def: "The formation from simpler components of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://en.wikipedia.org/] +subset: gosubset_prok +is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0043645 ! cephalosporin metabolic process + +[Term] +id: GO:0043647 +name: inositol phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [ChEBI:24848, GOC:jl] +synonym: "inositol phosphate metabolism" EXACT [] +synonym: "myo-inositol phosphate metabolic process" NARROW [] +synonym: "myo-inositol phosphate metabolism" NARROW [] +is_a: GO:0006020 ! inositol metabolic process + +[Term] +id: GO:0043648 +name: dicarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dicarboxylate metabolic process" EXACT [] +synonym: "dicarboxylate metabolism" EXACT [] +synonym: "dicarboxylic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0043649 +name: dicarboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dicarboxylate catabolic process" EXACT [] +synonym: "dicarboxylate catabolism" EXACT [] +synonym: "dicarboxylic acid breakdown" EXACT [] +synonym: "dicarboxylic acid catabolism" EXACT [] +synonym: "dicarboxylic acid degradation" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0043650 +name: dicarboxylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dicarboxylate biosynthesis" EXACT [] +synonym: "dicarboxylate biosynthetic process" EXACT [] +synonym: "dicarboxylic acid anabolism" EXACT [] +synonym: "dicarboxylic acid biosynthesis" EXACT [] +synonym: "dicarboxylic acid formation" EXACT [] +synonym: "dicarboxylic acid synthesis" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0043651 +name: linoleic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [http://en.wikipedia.org/wiki/Linoleic_Acid] +synonym: "linoleic acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0043652 +name: engulfment of apoptotic cell +namespace: biological_process +def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015] +synonym: "engulfment of apoptotic cell corpse" EXACT [] +synonym: "engulfment of cell corpse" EXACT [] +is_a: GO:0006911 ! phagocytosis, engulfment +relationship: part_of GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:0043653 +name: mitochondrial fragmentation during apoptosis +namespace: biological_process +def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:rk, PMID:12867994] +synonym: "mitochondrial fission during apoptosis" EXACT [] +is_a: GO:0008637 ! apoptotic mitochondrial changes + +[Term] +id: GO:0043654 +name: recognition of apoptotic cell +namespace: biological_process +def: "The process by which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015] +synonym: "detection of apoptotic cell" EXACT [] +synonym: "detection of apoptotic cell corpse" EXACT [] +synonym: "detection of cell corpse" EXACT [] +synonym: "recognition of apoptotic cell corpse" EXACT [] +synonym: "recognition of cell corpse" EXACT [] +is_a: GO:0006910 ! phagocytosis, recognition +relationship: part_of GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:0043655 +name: extracellular space of host +namespace: cellular_component +def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc] +subset: gosubset_prok +synonym: "host extracellular space" EXACT [] +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0018995 ! host + +[Term] +id: GO:0043656 +name: intracellular region of host +namespace: cellular_component +def: "That space within the plasma membrane of a host cell." [GOC:cc] +subset: gosubset_prok +synonym: "host intracellular" EXACT [] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0043657 +name: host cell +namespace: cellular_component +def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0018995 ! host + +[Term] +id: GO:0043658 +name: host symbiosome +namespace: cellular_component +def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc] +subset: gosubset_prok +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0043659 +name: symbiosome +namespace: cellular_component +def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc] +subset: gosubset_prok +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0043660 +name: bacteroid-containing symbiosome +namespace: cellular_component +def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc] +subset: gosubset_prok +is_a: GO:0043659 ! symbiosome + +[Term] +id: GO:0043661 +name: peribacteroid membrane +namespace: cellular_component +def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] +subset: gosubset_prok +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0043660 ! bacteroid-containing symbiosome + +[Term] +id: GO:0043662 +name: peribacteroid fluid +namespace: cellular_component +def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0043660 ! bacteroid-containing symbiosome + +[Term] +id: GO:0043663 +name: host bacteroid-containing symbiosome +namespace: cellular_component +def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc] +subset: gosubset_prok +is_a: GO:0043658 ! host symbiosome + +[Term] +id: GO:0043664 +name: host peribacteroid membrane +namespace: cellular_component +def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] +subset: gosubset_prok +is_a: GO:0033643 ! host cell part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome + +[Term] +id: GO:0043665 +name: host peribacteroid fluid +namespace: cellular_component +def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc] +subset: gosubset_prok +is_a: GO:0033643 ! host cell part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome + +[Term] +id: GO:0043666 +name: regulation of phosphoprotein phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0043667 +name: pollen wall +namespace: cellular_component +def: "The complex wall surrounding a pollen grain." [GOC:fz] +comment: Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific 'extracellular matrix (sensu Magnoliophyta) ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'extracellular matrix (sensu Magnoliophyta) ; GO:0048196'. +synonym: "micrsopore wall" EXACT [] +is_a: GO:0044420 ! extracellular matrix part + +[Term] +id: GO:0043668 +name: exine +namespace: cellular_component +def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that the exine is highly resistant to strong acids and bases. +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043667 ! pollen wall + +[Term] +id: GO:0043669 +name: ectexine +namespace: cellular_component +def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'. +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043670 +name: foot layer +namespace: cellular_component +def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/] +synonym: "nexine 1" EXACT [] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043669 ! ectexine + +[Term] +id: GO:0043671 +name: endexine +namespace: cellular_component +def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'. +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043672 +name: nexine +namespace: cellular_component +def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'. +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043673 +name: sexine +namespace: cellular_component +def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'. +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043674 +name: columella +namespace: cellular_component +def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/] +synonym: "sexine 1" EXACT [] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043673 ! sexine + +[Term] +id: GO:0043675 +name: sculpture element +namespace: cellular_component +def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043673 ! sexine + +[Term] +id: GO:0043676 +name: tectum +namespace: cellular_component +def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/] +synonym: "sexine 2" EXACT [] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043673 ! sexine + +[Term] +id: GO:0043677 +name: germination pore +namespace: cellular_component +def: "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [http://en.wikipedia.org/] +synonym: "germ pore" EXACT [] +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043667 ! pollen wall + +[Term] +id: GO:0043678 +name: intine +namespace: cellular_component +def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material. +is_a: GO:0044420 ! extracellular matrix part +relationship: part_of GO:0043667 ! pollen wall + +[Term] +id: GO:0043679 +name: nerve terminal +namespace: cellular_component +def: "A cell projection in which the distal end of the axon of a nerve fiber terminates. Sensory nerve endings are classified as either free or encapsulated. The free nerve ending are the most common type of nerve ending, and are most frequently found in the skin." [GOC:ef, GOC:mah] +synonym: "nerve ending" EXACT [] +synonym: "nerve terminal" EXACT [] +is_a: GO:0033267 ! axon part + +[Term] +id: GO:0043680 +name: filiform apparatus +namespace: cellular_component +def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208] +is_a: GO:0044426 ! cell wall part + +[Term] +id: GO:0043681 +name: protein import into mitochondrion +namespace: biological_process +def: "The directed movement of a protein from the cytoplasm to the mitochondrion." [GOC:jl] +is_a: GO:0006626 ! protein targeting to mitochondrion +is_a: GO:0017038 ! protein import + +[Term] +id: GO:0043682 +name: copper-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005375 ! copper ion transmembrane transporter activity +is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism + +[Term] +id: GO:0043683 +name: type IV pilus biogenesis +namespace: biological_process +def: "The assembly of a type IV pilus, composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation." [GOC:ml] +synonym: "TFP biogenesis" EXACT [] +synonym: "type 4 pilus biogenesis" EXACT [] +synonym: "type IV fimbria assembly" EXACT [] +synonym: "type IV fimbria biogenesis" EXACT [] +synonym: "type IV fimbriae assembly" EXACT [] +synonym: "type IV fimbriae biogenesis" EXACT [] +synonym: "type IV fimbrial assembly" EXACT [] +synonym: "type IV fimbrial biogenesis" EXACT [] +synonym: "type IV fimbrium assembly" EXACT [] +synonym: "type IV fimbrium biogenesis" EXACT [] +synonym: "type IV pilus biosynthesis" EXACT [] +is_a: GO:0009297 ! pilus biogenesis + +[Term] +id: GO:0043684 +name: type IV protein secretion system complex +namespace: cellular_component +def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of nucleoprotein DNA conjugation intermediates or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml] +subset: gosubset_prok +synonym: "T4SS complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0043685 +name: conversion of glutamyl-tRNA to glutaminyl-tRNA +namespace: biological_process +def: "Process whereby glutamate charged on a tRNA(Gln) is converted to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308] +comment: Note that this process has been observed in some archaeal and bacterial species. +subset: gosubset_prok +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0043686 +name: co-translational protein modification +namespace: biological_process +def: "The covalent alteration of one or more amino acids occurring in a protein before the protein has been completely translated and released from the ribosome." [GOC:jsg] +synonym: "co-translational amino acid modification" EXACT [] +synonym: "co-translational modification" EXACT [] +synonym: "cotranslational amino acid modification" EXACT [] +synonym: "cotranslational modification" EXACT [] +synonym: "cotranslational protein modification" EXACT [] +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0043687 +name: post-translational protein modification +namespace: biological_process +def: "The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] +subset: gosubset_prok +synonym: "post-translational amino acid modification" EXACT [] +synonym: "post-translational modification" EXACT [] +synonym: "posttranslational amino acid modification" EXACT [] +synonym: "posttranslational modification" EXACT [] +synonym: "posttranslational protein modification" EXACT [] +synonym: "PTM" EXACT [] +is_a: GO:0006464 ! protein modification process + +[Term] +id: GO:0043688 +name: conversion of aspartyl-tRNA to asparaginyl-tRNA +namespace: biological_process +def: "Process whereby aspartate charged on a tRNA(Asn) is converted to asparaginyl-tRNA." [GOC:jsg, PMID:9789001] +comment: Note that this process has been observed in some archeal and bacterial species. +subset: gosubset_prok +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0043689 +name: cell-cell adhesion during flocculation +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules, occurring as a part of the non-sexual aggregation of single-celled organisms." [GOC:jl] +subset: gosubset_prok +is_a: GO:0016337 ! cell-cell adhesion +relationship: part_of GO:0000128 ! flocculation + +[Term] +id: GO:0043690 +name: cell-cell adhesion during flocculation via cell wall protein-carbohydrate interaction +namespace: biological_process +def: "The attachment of one cell to another cell via protein-carbohydrate (flocculin-mannan) interaction, occurring as a part of the mannose-sensitive, nonsexual aggregation of cells." [GOC:jl] +subset: gosubset_prok +is_a: GO:0007157 ! heterophilic cell adhesion +is_a: GO:0016339 ! calcium-dependent cell-cell adhesion +is_a: GO:0043689 ! cell-cell adhesion during flocculation +relationship: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction + +[Term] +id: GO:0043691 +name: reverse cholesterol transport +namespace: biological_process +def: "The directed movement of periperal cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809] +is_a: GO:0030301 ! cholesterol transport + +[Term] +id: GO:0043692 +name: monoterpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [CHEBI:35187] +subset: gosubset_prok +synonym: "monoterpene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0043693 +name: monoterpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [CHEBI:35187] +subset: gosubset_prok +synonym: "monoterpene biosynthesis" EXACT [] +is_a: GO:0043692 ! monoterpene metabolic process +is_a: GO:0046246 ! terpene biosynthetic process + +[Term] +id: GO:0043694 +name: monoterpene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [CHEBI:35187] +subset: gosubset_prok +synonym: "monoterpene catabolism" EXACT [] +is_a: GO:0043692 ! monoterpene metabolic process +is_a: GO:0046247 ! terpene catabolic process + +[Term] +id: GO:0043695 +name: detection of pheromone +namespace: biological_process +def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0019236 ! response to pheromone + +[Term] +id: GO:0043696 +name: dedifferentiation +namespace: biological_process +def: "The process whereby a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0043697 +name: cell dedifferentiation +namespace: biological_process +def: "The process whereby a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] +is_a: GO:0043696 ! dedifferentiation +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0043698 +name: iridosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh] +synonym: "reflecting platelet" EXACT [] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043699 +name: leucosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh] +synonym: "refractosome" EXACT [] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043700 +name: pterinosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043701 +name: cyanosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043702 +name: carotenoid vesicle +namespace: cellular_component +def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vescicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0043703 +name: photoreceptor cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] +is_a: GO:0048664 ! neuron fate determination +relationship: part_of GO:0046552 ! photoreceptor cell fate commitment + +[Term] +id: GO:0043704 +name: photoreceptor cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0046552 ! photoreceptor cell fate commitment + +[Term] +id: GO:0043705 +name: cyanophycin metabolic process +namespace: biological_process +def: "The chemical reactions involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl] +synonym: "cyanophycin metabolism" EXACT [] +synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0043706 +name: heterophilic cell adhesion during cytoadherence to microvasculature, mediated by parasite protein +namespace: biological_process +def: "The attachment of a parasite adhesion molecule to a nonidentical adhesion molecule on the microvasculature of a host cell, thereby adhering the parasite to the host cell." [GOC:jl] +is_a: GO:0007157 ! heterophilic cell adhesion +relationship: part_of GO:0020035 ! cytoadherence to microvasculature, mediated by parasite protein + +[Term] +id: GO:0043707 +name: cell adhesion during single-species biofilm formation in or on host organism +namespace: biological_process +def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a surface in a host species." [GOC:jl] +is_a: GO:0043709 ! cell adhesion during single-species biofilm formation +relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism + +[Term] +id: GO:0043708 +name: cell adhesion during biofilm formation +namespace: biological_process +def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm." [GOC:jl] +is_a: GO:0007155 ! cell adhesion +relationship: part_of GO:0042710 ! biofilm formation + +[Term] +id: GO:0043709 +name: cell adhesion during single-species biofilm formation +namespace: biological_process +def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:jl] +is_a: GO:0043708 ! cell adhesion during biofilm formation +relationship: part_of GO:0044010 ! single-species biofilm formation + +[Term] +id: GO:0043710 +name: cell adhesion during multi-species biofilm formation +namespace: biological_process +def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of different species." [GOC:jl] +is_a: GO:0043708 ! cell adhesion during biofilm formation +relationship: part_of GO:0044399 ! multi-species biofilm formation + +[Term] +id: GO:0043711 +name: pilus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl] +subset: gosubset_prok +synonym: "pilus organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0043712 +name: 2-hydroxyisocaproate CoA-transferase +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoisocaproate + CoA = (R)-2-hydroxyisocaproyl-CoA." [PMID:16957230] +synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [] +synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT [] +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043713 +name: (R)-2-hydroxyisocaproate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230] +subset: gosubset_prok +xref: EC:1.1.1.- +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043714 +name: (R)-citramalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346] +subset: gosubset_prok +synonym: "citramalate synthase" BROAD [] +xref: EC:2.3.3.- +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0043715 +name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity +namespace: molecular_function +def: "Catalysis of the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)." [UniProtKB:Q81MJ2] +comment: This function is part of the process of methionine salvage. +subset: gosubset_prok +synonym: "DK-MTP-1-P enolase activity" EXACT [] +synonym: "E-1" RELATED [] +synonym: "MasA" RELATED [] +synonym: "mtnW" RELATED [] +xref: EC:5.3.2.- +xref: MetaCyc:R82-RXN +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0043716 +name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity +namespace: molecular_function +def: "Cataysis of the dephosphorylation of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-P) to 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)." [IMG:01681, UniProtKB:O31667] +subset: gosubset_prok +synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT [] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043717 +name: 2-hydroxyglutaryl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the dehydration of 2-hydroxyglutaryl-CoA to glutaconyl-CoA." [UniProtKB:P11569] +subset: gosubset_prok +synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT [] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043718 +name: 2-hydroxymethylglutarate dehydrogenase +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+." [EC:1.1.1.291] +subset: gosubset_prok +synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.291] +synonym: "HgD" EXACT [] +xref: EC:1.1.1.291 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043719 +name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase +namespace: molecular_function +def: "Catalysis of the introduction of a hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol to form 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol." [GOC:jl, UniProtKB:P75728] +subset: gosubset_prok +xref: EC:1.14.13.- +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0043720 +name: 3-keto-5-aminohexanoate cleavage activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [PMID:13064] +subset: gosubset_prok +synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT [] +xref: MetaCyc:R125-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0043721 +name: 4-hydroxybutyryl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the formation of vinylacetyl-CoA from 4-hydroxybutyryl-CoA." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT [] +xref: EC:4.2.1.- +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043722 +name: 4-hydroxyphenylacetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2." [EC:4.1.1.83] +subset: gosubset_prok +synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" EXACT [EC:4.1.1.83] +synonym: "4-Hpd activity" EXACT [EC:4.1.1.83] +synonym: "4-hydroxyphenylacetate carboxy-lyase activity" EXACT [EC:4.1.1.83] +synonym: "p-Hpd activity" EXACT [EC:4.1.1.83] +synonym: "p-hydroxyphenylacetate decarboxylase activity" EXACT [EC:4.1.1.83] +xref: EC:4.1.1.83 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0043723 +name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NH3." [PMID:11889103] +subset: gosubset_prok +synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [] +xref: EC:3.5.4.- +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0043724 +name: 2-keto-3-deoxygalactonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170] +subset: gosubset_prok +synonym: "KDGal aldolase activity" EXACT [] +xref: EC:4.2.1.- +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043725 +name: 2-keto-3-deoxygluconate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate." [PMID:12824170] +subset: gosubset_prok +synonym: "KDG aldolase activity" EXACT [] +xref: EC:4.2.1.- +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043726 +name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282] +subset: gosubset_prok +xref: EC:3.1.3.- +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043727 +name: 5-amino-4-imidazole carboxylate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835] +subset: gosubset_prok +xref: EC:4.1.1.- +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0043728 +name: 2-keto-4-methylthiobutyrate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683] +subset: gosubset_prok +xref: EC:4.1.1.- +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043729 +name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536] +subset: gosubset_prok +xref: EC:4.-.-.- +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0043730 +name: 5-ureido-4-imidazole carboxylate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121] +subset: gosubset_prok +xref: EC:3.5.3.- +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0043731 +name: 6-hydroxynicotinate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591] +subset: gosubset_prok +xref: EC:1.14.13.- +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0043732 +name: 6-hydroxynicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O." [EC:1.17.3.3] +subset: gosubset_prok +synonym: "6-hydroxynicotinate hydroxylase activity" EXACT [EC:1.17.3.3] +synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" EXACT [EC:1.17.3.3] +synonym: "6-hydroxynicotinic acid dehydrogenase activity" EXACT [EC:1.17.3.3] +synonym: "6-hydroxynicotinic acid hydroxylase activity" EXACT [EC:1.17.3.3] +xref: EC:1.17.3.3 +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0043733 +name: DNA-3-methyladenine glycosylase III activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated 3-methylpurines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site." [IMG:00576, PMID:10777493, PMID:14517230] +subset: gosubset_prok +synonym: "Mag III" NARROW [] +synonym: "MagIII" NARROW [] +xref: EC:3.2.2.- +xref: IMG:00576 +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0043734 +name: DNA-N1-methyladenine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methylgroup on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, UniProtKB:P05050] +subset: gosubset_prok +synonym: "AlkB" NARROW [] +synonym: "alkB" NARROW [] +synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW [] +xref: EC:1.14.11.- +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0043735 +name: delta-9 acyl-phospholipid desaturase activity +namespace: molecular_function +subset: gosubset_prok +synonym: "MpgII" NARROW [] +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0043736 +name: DNA-3-methyladenine glycosylase IV activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [IMG:00578, PMID:10375529] +subset: gosubset_prok +synonym: "Mpg II" NARROW [] +synonym: "MpgII" NARROW [] +xref: EC:3.2.2.- +xref: IMG:00578 +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0043737 +name: deoxyribonuclease V activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7] +synonym: "DNase V activity" EXACT [EC:3.1.21.7] +synonym: "endodeoxyribonuclease V" EXACT [] +synonym: "endonuclease V activity" BROAD [EC:3.1.21.7] +synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7] +xref: EC:3.1.21.7 +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0043738 +name: F420H2 dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanophenazine + reduced cofactor F420 = dihydromethanophenazine + cofactor F420." [MetaCyc:CPLX-7105] +subset: gosubset_prok +xref: EC:1.-.-.- +xref: MetaCyc:CPLX-7105 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043739 +name: G/U mismatch-specific uracil-DNA glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825] +subset: gosubset_prok +synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT [] +synonym: "MUG" EXACT [] +synonym: "uracil mismatch repair protein" BROAD [] +is_a: GO:0004844 ! uracil DNA N-glycosylase activity +is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity + +[Term] +id: GO:0043740 +name: GTP cyclohydrolase IIa activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate." [EC:3.5.4.29] +subset: gosubset_prok +synonym: "GTP 8,9-dihydrolase (phosphate-forming)" EXACT [EC:3.5.4.29] +synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT [] +synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29] +xref: EC:3.5.4.29 +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0043741 +name: L-2-aminoadipate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0043743 +name: LPPG:FO 2-phospho-L-lactate transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551] +subset: gosubset_prok +xref: EC:2.7.1.- +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043744 +name: N2-acetyl-L-aminoadipate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate + ATP = N2-acetyl-L-aminoadipyl-delta-phosphate + ADP." [IMG:01448] +subset: gosubset_prok +xref: EC:2.7.2.- +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0043745 +name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449] +subset: gosubset_prok +xref: EC:1.2.1.- +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043746 +name: N2-acetyl-L-lysine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450] +subset: gosubset_prok +synonym: "N-acetyl-lysine aminotransferase activity" EXACT [] +xref: EC:2.6.1.- +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043747 +name: N2-acetyl-L-lysine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [IMG:01451] +subset: gosubset_prok +synonym: "N-acetyl-lysine deacetylase activity" EXACT [] +xref: EC:3.5.1.- +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043748 +name: O-succinylbenzoate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733] +subset: gosubset_prok +xref: EC:3.5.1.- +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043749 +name: phenol, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277] +subset: gosubset_prok +synonym: "ATP:phenol:water phosphotransferase activity" EXACT [] +synonym: "phenol:water dikinase activity" EXACT [] +synonym: "phenylphosphate synthase activity" EXACT [] +xref: EC:2.7.9.- +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0043750 +name: phosphatidylinositol alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.57] +subset: gosubset_prok +synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] +synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] +synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] +synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57] +synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] +synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57] +xref: EC:2.4.1.57 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0043751 +name: polyphosphate:AMP phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "PAP" EXACT [] +synonym: "PPT" EXACT [] +xref: EC:2.7.4.- +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0043752 +name: adenosylcobinamide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156] +subset: gosubset_prok +synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] +synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] +synonym: "CobU" RELATED [] +synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT [] +xref: EC:2.7.1.156 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043753 +name: adenosylcobinamide-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP." [EC:2.7.7.62] +subset: gosubset_prok +synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] +synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] +synonym: "CobU" RELATED [] +synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] +xref: EC:2.7.7.62 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0043754 +name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168] +subset: gosubset_prok +synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] +synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168] +synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168] +synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT [] +xref: EC:2.3.1.168 +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0043755 +name: alpha-ribazole phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate." [EC:3.1.3.73] +subset: gosubset_prok +synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT [] +synonym: "CobC" RELATED [] +xref: EC:3.1.3.73 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043756 +name: adenosylcobinamide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol." [EC:3.5.1.90] +subset: gosubset_prok +synonym: "adenosylcobinamide amidohydrolase activity" EXACT [EC:3.5.1.90] +synonym: "AdoCbi amidohydrolase activity" EXACT [EC:3.5.1.90] +synonym: "AdoCbi hydrolase activity" EXACT [EC:3.5.1.90] +synonym: "CbiZ" RELATED [] +xref: EC:3.5.1.90 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043757 +name: adenosylcobinamide-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate and (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10] +subset: gosubset_prok +synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT [] +synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10] +synonym: "CbiB" RELATED [] +xref: EC:6.3.1.10 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0043758 +name: acetate-CoA ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [EC:6.2.1.13] +subset: gosubset_prok +synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13] +synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT [] +synonym: "acetate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.13] +synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT [] +synonym: "acetyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.13] +xref: EC:6.2.1.13 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0043759 +name: branched-chain acyl-CoA synthetase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425] +subset: gosubset_prok +synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT [] +synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT [] +synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT [] +xref: EC:6.2.1.- +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0043760 +name: acetyldiaminopimelate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065] +subset: gosubset_prok +synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT [] +synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT [] +xref: EC:2.6.1.- +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043761 +name: archaetidylserine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787] +subset: gosubset_prok +synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT [] +synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT [] +xref: EC:2.7.8.- +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0043762 +name: aryl-CoA synthetase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427] +subset: gosubset_prok +xref: EC:6.2.1.- +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0043763 +name: UTP:glucose-1-phosphate uridylyltransferase regulator activity +namespace: molecular_function +def: "Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl] +subset: gosubset_prok +synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT [] +synonym: "UDP-glucose diphosphorylase regulator activity" EXACT [] +synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0043764 +name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]." [IMG:00545, InterPro:IPR007691] +subset: gosubset_prok +xref: EC:2.3.1.- +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0043765 +name: T/G mismatch-specific endonuclease activity +namespace: molecular_function +def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184] +subset: gosubset_prok +synonym: "DNA mismatch endonuclease" BROAD [] +synonym: "V.EcoKDcm" RELATED [] +synonym: "very short patch repair protein" RELATED [] +synonym: "Vsr mismatch endonuclease" RELATED [] +xref: EC:3.1.-.- +is_a: GO:0004519 ! endonuclease activity + +[Term] +id: GO:0043766 +name: Sep-tRNA:Cys-tRNA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoseryl-tRNA(Cys) + H2S = cysteinyl-tRNA(Cys) + orthophosphate." [IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438] +subset: gosubset_prok +synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT [] +synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT [] +synonym: "SepCysS" RELATED [] +xref: EC:2.5.1.- +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0043767 +name: pyrrolysyl-tRNA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + pyrophosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8] +subset: gosubset_prok +synonym: " Pyrrolysine-tRNA ligase activity" EXACT [] +synonym: "PylRS" EXACT [] +xref: EC:6.1.1.- +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0043768 +name: S-ribosylhomocysteine lyase activity +namespace: molecular_function +alt_id: GO:0019138 +def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione." [EC:4.4.1.21, IMG:02085] +subset: gosubset_prok +synonym: "3.2.1.148" RELATED [] +synonym: "LuxS" RELATED [] +synonym: "ribosylhomocysteinase activity" EXACT [] +synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21] +synonym: "S-ribosylhomocysteinase activity" EXACT [] +xref: EC:4.4.1.21 +xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0043769 +name: Tpg-containing telomere binding complex +namespace: cellular_component +def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591] +subset: gosubset_prok +synonym: "telomere complex" BROAD [] +is_a: GO:0000782 ! telomere cap complex + +[Term] +id: GO:0043770 +name: demethylmenaquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043771 +name: cytidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [IMG:01870] +subset: gosubset_prok +xref: EC:2.7.1.- +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043772 +name: acyl-phosphate glycerol-3-phosphate acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305] +subset: gosubset_prok +synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] +synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT [] +synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0043773 +name: coenzyme F420-0 gamma-glutamyl ligase activity +namespace: molecular_function +def: "Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates, i.e. GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1 followed by GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2." [IMG:01552, UniProtKB:Q58178] +subset: gosubset_prok +synonym: "F420-0 gamma-glutamyl ligase activity" EXACT [] +xref: EC:6.3.2.- +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0043774 +name: coenzyme F420-2 alpha-glutamyl ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553] +subset: gosubset_prok +synonym: "F420-2 alpha-glutamyl ligase activity" EXACT [] +xref: EC:6.3.2.- +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0043775 +name: cobyrinate a,c-diamide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814] +subset: gosubset_prok +synonym: "cobyrinate a c diamide synthase activity" EXACT [] +synonym: "cobyrinate a c-diamide synthase activity" EXACT [] +synonym: "cobyrinate a,c diamide synthase activity" EXACT [] +xref: EC:6.3.5.- +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0043776 +name: cobalt-precorrin-6B C5-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766] +subset: gosubset_prok +synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT [] +synonym: "precorrin-6 methyltransferase activity" EXACT [] +synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] +synonym: "precorrin-6Y methylase" BROAD [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8766 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043777 +name: cobalt-precorrin-7 C15-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767] +subset: gosubset_prok +synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT [] +synonym: "precorrin-6 methyltransferase" BROAD [] +synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] +synonym: "precorrin-6Y methylase" BROAD [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8767 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043778 +name: cobalt-precorrin-8 methylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [IMG:02117, MetaCyc:RXN-8768] +subset: gosubset_prok +synonym: "cobalt-precorrin 8 methylmutase activity" EXACT [] +synonym: "cobalt-precorrin 8X methylmutase activity" EXACT [] +synonym: "cobalt-precorrin-8X methylmutase activity" EXACT [] +xref: EC:5.4.1.- +xref: MetaCyc:RXN-8768 +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0043779 +name: cobalt-precorrin-5A acetaldehyde-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763] +subset: gosubset_prok +synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT [] +xref: MetaCyc:RXN-8763 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0043780 +name: cobalt-precorrin-5B C1-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764] +subset: gosubset_prok +synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8764 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043781 +name: cobalt-factor II C20-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812] +subset: gosubset_prok +synonym: "CbiL" NARROW [] +synonym: "cobalt-factor II C20 methyltransferase activity" EXACT [] +synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" EXACT [EC:2.1.1.151] +synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" EXACT [EC:2.1.1.151] +xref: EC:2.1.1.151 +xref: MetaCyc:RXN-8760 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043782 +name: cobalt-precorrin-3 C17-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761, UniProtKB:Q05590] +subset: gosubset_prok +synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT [] +synonym: "cobalt-precorrin-3 methylase" BROAD [] +synonym: "cobalt-precorrin-3 methyltransferase" BROAD [] +synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8761 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043783 +name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8] +subset: gosubset_prok +xref: EC:1.16.8 +is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions + +[Term] +id: GO:0043784 +name: cob(II)yrinic acid a,c-diamide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 cob(II)yrinic acid a,c-diamide + FMN = 2 cob(I)yrinic acid a,c-diamide + FMNH2." [EC:1.16.8.1] +subset: gosubset_prok +synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT [] +xref: EC:1.16.8.1 +is_a: GO:0043783 ! oxidoreductase activity, oxidizing metal ions with flavin as acceptor + +[Term] +id: GO:0043785 +name: cinnamoyl-CoA:phenyllactate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-cinnamoyl-CoA + (R)-phenyllactate = (E)-cinnamate + (R)-phenyllactyl-CoA." [EC:2.8.3.17] +subset: gosubset_prok +synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT [] +synonym: "FldA" RELATED [] +xref: EC:2.8.3.17 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043786 +name: cinnamate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007] +subset: gosubset_prok +xref: EC:1.3.1.- +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043787 +name: chlorophyll synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyllide a + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, IMG:01750] +subset: gosubset_prok +synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT [] +xref: EC:2.5.1.62 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0043788 +name: cardiolipin synthetase 2 activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 1,2-diacyl-sn-glycero-3-[phospho-rac-(1-glycerol)] = cardiolipin + glycerol." [IMG:00156] +subset: gosubset_prok +synonym: "cardiolipin synthase 2 activity" EXACT [] +xref: EC:2.7.8.- +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0043789 +name: diguanylate cyclase activity +namespace: molecular_function +def: "Catalysis of the conversion of 2GTP to bis-(3'-5')cyclic guanylic acid, via linear diguanosine tetraphosphate pppg 3'p5'g, releasing 1 pyrophosphate at each step." [http://cancerweb.ncl.ac.uk/, IMG:02393, PMID:16895465] +subset: gosubset_prok +xref: EC:4.6.1.- +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0043790 +name: dimethyladenosine transferase activity +namespace: molecular_function +def: "Catalysis of the dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle." [IMG:02532, UniProtKB:Q6C7H6] +subset: gosubset_prok +synonym: "18S rRNA dimethylase activity" EXACT [] +synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [] +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043791 +name: dimethylamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228, UniProtKB:O93661] +comment: This function is the first step in the pathway of methanogenesis from dimethylamine. +subset: gosubset_prok +synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT [] +synonym: "DMA methyltransferase 1" EXACT [] +synonym: "DMAMT 1" EXACT [] +synonym: "MT1" BROAD [] +synonym: "mtbB1" RELATED [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8100 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043792 +name: enamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH." [EC:3.5.2.18] +subset: gosubset_prok +synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT [] +xref: EC:3.5.2.18 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0043793 +name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + pyrophosphate." [GOC:jl, IMG:01544, PMID:12142414] +subset: gosubset_prok +synonym: "beta-RFAP synthase activity" EXACT [] +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0043794 +name: formate dehydrogenase (F420) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411] +subset: gosubset_prok +xref: EC:1.2.99.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0043795 +name: glyceraldehyde oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506] +subset: gosubset_prok +xref: EC:1.2.-.-. +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0043796 +name: glyceraldehyde dehydrogenase (NADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [IMG:01555] +subset: gosubset_prok +xref: EC:1.2.1.- +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043797 +name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6] +subset: gosubset_prok +synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT [] +synonym: "GAPOR" RELATED [] +synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" EXACT [EC:1.2.7.6] +synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" EXACT [EC:1.2.7.6] +xref: EC:1.2.7.6 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043798 +name: glycerate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, MetaCyc:GKI-RXN, PMID:14413719] +subset: gosubset_prok +synonym: "D-glycerate 2-kinase activity" EXACT [] +synonym: "glycerate kinase" BROAD [] +xref: EC:2.7.1.- +xref: MetaCyc:GKI-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0043799 +name: glycine oxidase activity +namespace: molecular_function +def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (2) D-alanine + H2O + O2 = pyruvate + NH3 + H2O2 (3) sarcosine + H2O + O2 = glyoxylate + methylamine + H2O2 (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + H2O2." [EC:1.4.3.19] +subset: gosubset_prok +synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT [] +xref: EC:1.4.3.19 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0043800 +name: hexulose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, UniProtKB:P44990] +subset: gosubset_prok +synonym: "HUMPI" EXACT [] +xref: EC:5.-.-.- +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0043801 +name: hexulose-6-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, UniProtKB:Q5WCM6] +subset: gosubset_prok +xref: EC:4.1.2.- +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0043802 +name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate." [EC:6.3.5.9] +subset: gosubset_prok +synonym: "CobB" RELATED [] +synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT [] +synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT [] +xref: EC:6.3.5.9 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0043803 +name: hydroxyneurosporene-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759] +subset: gosubset_prok +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043804 +name: imidazolone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O." [IMG:02122] +subset: gosubset_prok +xref: EC:3.5.2.- +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0043805 +name: indolepyruvate ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8] +subset: gosubset_prok +synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" EXACT [EC:1.2.7.8] +synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" EXACT [EC:1.2.7.8] +synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8] +synonym: "IOR" RELATED [] +xref: EC:1.2.7.8 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043806 +name: keto acid formate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, UniProtKB:P42632] +subset: gosubset_prok +synonym: "keto-acid formate acetyltransferase" BROAD [] +synonym: "keto-acid formate lyase activity" EXACT [] +synonym: "keto-acid formate-lyase activity" EXACT [] +xref: EC:2.3.1.- +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0043807 +name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7] +subset: gosubset_prok +synonym: "2-ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] +synonym: "2-oxoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] +synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" EXACT [EC:1.2.7.7] +synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT [] +synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "keto-valine-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.7] +synonym: "ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7] +synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7] +synonym: "VOR" RELATED [] +xref: EC:1.2.7.7 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043808 +name: lyso-ornithine lipid acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl carrier protein] = ornithine lipid + [acyl carrier protein]." [IMG:02097, PMID:15341653] +subset: gosubset_prok +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0043809 +name: methylthioribulose 1-phosphate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O." [EC:4.2.1.109] +subset: gosubset_prok +synonym: "1-PMT-ribulose dehydratase activity" EXACT [EC:4.2.1.109] +synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT [] +synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109] +synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT [] +synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT [] +xref: EC:4.2.1.109 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043810 +name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl carrier protein]." [IMG:02096] +subset: gosubset_prok +synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT [] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0043811 +name: phosphate:acyl-[acyl carrier protein] acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl carrier protein] + orthophosphate = acyl phosphate + [acyl carrier protein]." [IMG:01871] +subset: gosubset_prok +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0043812 +name: phosphatidylinositol-4-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360] +subset: gosubset_prok +synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT [] +xref: EC:3.1.3.- +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0043813 +name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidyInositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, UniProtKB:P42837] +subset: gosubset_prok +synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT [] +xref: EC:3.1.3.- +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity +is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity + +[Term] +id: GO:0043814 +name: phospholactate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + pyrophosphate." [IMG:01547] +subset: gosubset_prok +xref: EC:2.7.7.- +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0043815 +name: phosphoribosylglycinamide formyltransferase 2 activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [IMG:01297, UniProtKB:P33221] +subset: gosubset_prok +synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT [] +synonym: "formate-dependent GAR transformylase activity" EXACT [] +synonym: "GAR transformylase 2" RELATED [] +synonym: "GART 2" RELATED [] +xref: EC:2.1.2.- +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0043816 +name: phosphoserine-tRNA(Cys) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + pyrophosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438] +subset: gosubset_prok +synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT [] +synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT [] +synonym: "phosphoserine-tRNACys ligase activity" EXACT [] +synonym: "SepRS" RELATED [] +xref: EC:6.1.1.- +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0043817 +name: phosphosulfolactate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = sulfite + phosphoenolpyruvate." [IMG:00622] +subset: gosubset_prok +synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.4.1.19] +synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT [] +synonym: "(2R)-phospho-3-sulfolactate synthase activity" EXACT [EC:4.4.1.19] +synonym: "PSL synthase activity" EXACT [EC:4.4.1.19] +xref: EC:4.4.1.19 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0043818 +name: precorrin-3B synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O." [IMG:01805] +subset: gosubset_prok +synonym: "CobG" RELATED [] +synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT [] +synonym: "precorrin-3X synthase activity" EXACT [EC:1.14.13.83] +xref: EC:1.14.13.83 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0043819 +name: precorrin-6A synthase (deacetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate." [EC:2.1.1.152, IMG:01802] +subset: gosubset_prok +synonym: "CobF" RELATED [] +synonym: "precorrin-6X synthase (deacetylating) activity" EXACT [EC:2.1.1.152] +synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT [] +xref: EC:2.1.1.152 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043820 +name: propionyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323] +subset: gosubset_prok +xref: EC:1.3.99.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0043821 +name: propionyl-CoA:succinate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268] +subset: gosubset_prok +synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT [] +synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT [] +xref: EC:2.8.3.- +xref: MetaCyc:RXN0-268 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043822 +name: ribonuclease M5 activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522] +subset: gosubset_prok +synonym: "5S ribosomal maturation nuclease activity" EXACT [EC:3.1.26.8] +synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT [] +synonym: "RNase M5 activity" EXACT [EC:3.1.26.8] +xref: EC:3.1.26.8 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0043823 +name: spheroidene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the conversion of spheroidene to spheroidenone." [IMG:01761, PMID:16086104, PMID:16158287] +subset: gosubset_prok +xref: EC:1.14.-.- +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0043824 +name: succinylglutamate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+." [EC:1.2.1.71, IMG:00484] +subset: gosubset_prok +synonym: "AruD" RELATED [] +synonym: "AstD" RELATED [] +synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.71] +synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] +synonym: "SGSD" RELATED [] +synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT [] +synonym: "succinylglutamic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71] +xref: EC:1.2.1.71 +xref: MetaCyc:SUCCGLUALDDEHYD-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043825 +name: succinylornithine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, IMG:00483] +subset: gosubset_prok +synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.81] +synonym: "AstC" RELATED [] +synonym: "N(2)-succinylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.81] +synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [] +synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT [] +synonym: "SOAT" RELATED [] +synonym: "succinyl ornithine transaminase activity" EXACT [] +synonym: "succinyl-ornithine transaminase activity" EXACT [EC:2.6.1.81] +synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81] +xref: EC:2.6.1.81 +xref: MetaCyc:SUCCORNTRANSAM-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043826 +name: sulfur oxygenase reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5 S0 + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063] +subset: gosubset_prok +synonym: "SOR" RELATED [] +synonym: "sulphur oxygenase reductase activity" EXACT [] +xref: EC:1.-.-.- +xref: MetaCyc:RXN-8226 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043827 +name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239] +subset: gosubset_prok +synonym: "TrmI" RELATED [] +synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT [] +synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT [] +synonym: "tRNA (m1A) MTase" BROAD [] +xref: EC:2.1.1.- +is_a: GO:0016429 ! tRNA (adenine-N1-)-methyltransferase activity + +[Term] +id: GO:0043828 +name: tRNA 2-selenouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281, UniProtKB:Q8Z8R4] +subset: gosubset_prok +synonym: "B0503" RELATED [] +synonym: "SelU" RELATED [] +synonym: "YbbB" RELATED [] +xref: EC:2.9.1.- +xref: MetaCyc:RXN0-2281 +is_a: GO:0016786 ! selenotransferase activity + +[Term] +id: GO:0043829 +name: tRNA-specific adenosine-37 deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, UniProtKB:P53065] +subset: gosubset_prok +synonym: "TAD1" RELATED [] +synonym: "tRNA(Ala)-A37 deaminase activity" EXACT [] +synonym: "tRNA-specific adenosine deaminase 1" EXACT [] +xref: EC:3.5.4.- +is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity + +[Term] +id: GO:0043830 +name: thiol-driven fumarate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466] +subset: gosubset_prok +xref: EC:1.3.99.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0043831 +name: thiosulfate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 thiosulfate + 2 6-decylubiquinone = tetrathionate + 2 6-decylubiquinol." [EC:1.8.5.2, IMG:00714, MetaCyc:1.8.5.2-RXN] +subset: gosubset_prok +synonym: "DoxA" RELATED [] +synonym: "DoxD" RELATED [] +synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" EXACT [EC:1.8.5.2] +synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" EXACT [EC:1.8.5.2] +synonym: "thiosulfate:quinone oxidoreductase activity" EXACT [EC:1.8.5.2] +synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT [] +synonym: "thiosulphate:quinone oxidoreductase activity" EXACT [] +synonym: "TQO" RELATED [] +xref: EC:1.8.5.2 +xref: MetaCyc:1.8.5.2-RXN +is_a: GO:0016672 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0043832 +name: trans-2, cis-3 decenoyl-ACP isomerase activity +namespace: molecular_function +def: "Catalysis of the isomerization of trans-2-decenoyl-ACP to cis-3-decenoyl-ACP." [IMG:02508, PMID:12237320] +subset: gosubset_prok +synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT [] +xref: EC:5.3.3.- +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0043833 +name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099, UniProtKB:P58984] +comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine. +subset: gosubset_prok +synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] +synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT [] +synonym: "methylcobamide:coenzyme M methyltransferase activity" EXACT [] +synonym: "methylcobamide:CoM methyltransferase activity" EXACT [] +synonym: "methylcobamide:CoM methyltransferase II isozyme A" RELATED [] +synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] +synonym: "MT2" BROAD [] +synonym: "MT2-A" RELATED [] +synonym: "MtbA" RELATED [] +synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8099 +xref: MetaCyc:RXN-8101 +xref: MetaCyc:RXN-8103 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043834 +name: trimethylamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102, UniProtKB:Q8TTA9] +comment: This function is the first step in the pathway of methanogenesis from trimethylamine. +subset: gosubset_prok +synonym: "MT1" BROAD [] +synonym: "mttB1" RELATED [] +synonym: "TMA methyltransferase 1" EXACT [] +synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8102 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043835 +name: uracil/thymine dehydrogenase activity +namespace: molecular_function +def: "Catalyzes the reactions: (1) uracil + H2O + acceptor = barbiturate + reduced acceptor (2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821] +subset: gosubset_prok +synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4] +synonym: "uracil-thymine oxidase activity" EXACT [EC:1.17.99.4] +synonym: "uracil:acceptor oxidoreductase activity" EXACT [] +xref: EC:1.17.99.4 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0043836 +name: xanthine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN] +subset: gosubset_prok +synonym: "xanthinase activity" EXACT [] +xref: EC:3.5.2.- +xref: MetaCyc:R127-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0043837 +name: valine dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH." [IMG:00766, UniProtKB:O69056] +subset: gosubset_prok +synonym: "ValDH" RELATED [] +xref: EC:1.4.1.- +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043838 +name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227] +comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid. +subset: gosubset_prok +synonym: "EptB" RELATED [] +synonym: "phosphoethanolamine transferase" BROAD [] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0043839 +name: lipid A phosphate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate moiety of lipid A." [IMG:02094, PMID:15994324, UniProtKB:Q4FAC7] +subset: gosubset_prok +synonym: "lipid A 1-phosphomethyltransferase activity" EXACT [] +synonym: "lipid A methyltransferase" BROAD [] +synonym: "lipid A phosphomethyltransferase activity" EXACT [] +synonym: "LmtA" RELATED [] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0043840 +name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965] +subset: gosubset_prok +synonym: "BCAT" RELATED [] +synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] +synonym: "branched-chain amino acid aminotransferase" BROAD [] +synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] +xref: EC:2.6.1.- +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043841 +name: (S)-lactate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:00356, PMID:11535063] +subset: gosubset_prok +synonym: "lactate 2-kinase activity" EXACT [] +xref: EC:2.7.1.- +xref: MetaCyc:RXN-8076 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043842 +name: Kdo transferase activity +namespace: molecular_function +def: "Catalysis of the reactions: (1) (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP (2) lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966] +subset: gosubset_prok +synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT [] +synonym: "kdtA" RELATED [] +synonym: "WaaA" RELATED [] +xref: EC:2.-.-.- +xref: MetaCyc:KDOTRANS-RXN +xref: MetaCyc:KDOTRANS2-RXN +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0043843 +name: ADP-specific glucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468] +subset: gosubset_prok +synonym: "ADP-dependent glucokinase activity" EXACT [EC:2.7.1.147] +synonym: "ADP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.147] +xref: EC:2.7.1.147 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043844 +name: ADP-specific phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469] +subset: gosubset_prok +synonym: "ADP-6-phosphofructokinase activity" EXACT [EC:2.7.1.146] +synonym: "ADP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.146] +synonym: "ADP-Pfk activity" EXACT [EC:2.7.1.146] +synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.146] +xref: EC:2.7.1.146 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043845 +name: DNA polymerase III, proofreading complex +namespace: cellular_component +def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [http://en.wikipedia.org/wiki/Pol_III, IMG:01721] +subset: gosubset_prok +synonym: "DNA polymerase III, proof-reading complex" EXACT [] +synonym: "DNA polymerase III, proof-reading subcomplex" EXACT [] +synonym: "DNA polymerase III, proofreading subcomplex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0009360 ! DNA polymerase III complex + +[Term] +id: GO:0043846 +name: DNA polymerase III, DnaX complex +namespace: cellular_component +def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977] +subset: gosubset_prok +synonym: "clamp loader complex" BROAD [] +synonym: "DNA polymerase III, clamp loader complex" EXACT [] +synonym: "DNA polymerase III, DnaX subcomplex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0009360 ! DNA polymerase III complex + +[Term] +id: GO:0043847 +name: DNA polymerase III, DnaX complex, chi/psi subcomplex +namespace: cellular_component +def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III DnaX complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977] +subset: gosubset_prok +synonym: "DNA polymerase III, clamp loader chi/psi subcomplex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0043846 ! DNA polymerase III, DnaX complex + +[Term] +id: GO:0043848 +name: excinuclease cho activity +namespace: molecular_function +def: "Catalyzes the incision of the DNA at the 3' side of a lesion." [IMG:00499, UniProtKB:P59439] +comment: Note that this function occurs as part of nucleotide excision repair (NER). +subset: gosubset_prok +synonym: "cho" RELATED [] +synonym: "endonuclease cho" EXACT [] +synonym: "uvrc homolog protein" RELATED [] +is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base + +[Term] +id: GO:0043849 +name: Ras palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, UniProtKB:Q4I2M7] +subset: gosubset_prok +synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED [] +synonym: "ERF2" RELATED [] +synonym: "palmitoyltransferase ERF2" RELATED [] +synonym: "Ras protein acyltransferase activity" EXACT [] +xref: EC:2.3.1.- +is_a: GO:0016409 ! palmitoyltransferase activity + +[Term] +id: GO:0043850 +name: RecFOR complex +namespace: cellular_component +def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044427 ! chromosomal part + +[Term] +id: GO:0043851 +name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methanol corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096] +comment: This function is the second step in the pathway of methanogenesis from methanol. +subset: gosubset_prok +synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT [] +synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT [] +synonym: "methyltransferase 2" BROAD [] +synonym: "MT2" BROAD [] +synonym: "MtaA" RELATED [] +synonym: "MtaC protein: coenzyme M methyltransferase activity" EXACT [] +synonym: "MtaC protein:coenzyme M methyltransferase activity" EXACT [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8096 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043852 +name: monomethylamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + ammonia." [IMG:01319, MetaCyc:RXN-8098] +comment: This function is the first step in the pathway of methanogenesis from monomethylamine. +subset: gosubset_prok +synonym: "MMAMT" RELATED [] +synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT [] +synonym: "MtmB" RELATED [] +xref: EC:2.1.1.- +xref: MetaCyc:RXN-8098 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043853 +name: methanol-CoM methyltransferase complex +namespace: cellular_component +def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780] +subset: gosubset_prok +synonym: "methanol-coenzyme M methyltransferase complex" EXACT [] +synonym: "methanol: coenzyme M methyltransferase complex" EXACT [] +synonym: "methanol: CoM methyltransferase complex" EXACT [] +synonym: "methanol:coenzyme M methyltransferase complex" EXACT [] +synonym: "methanol:CoM methyltransferase complex" EXACT [] +xref: MetaCyc:CPLX-421 +is_a: GO:0034708 ! methyltransferase complex + +[Term] +id: GO:0043854 +name: cyclic nucleotide-gated mechanosensitive ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416] +subset: gosubset_prok +synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT [] +synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT [] +synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT [] +synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED [] +synonym: "MscS" RELATED [] +synonym: "small conductance mechanosensitive ion channel" EXACT [] +is_a: GO:0008381 ! mechanically-gated ion channel activity +is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity + +[Term] +id: GO:0043855 +name: cyclic nucleotide-gated ion channel activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl] +subset: gosubset_prok +synonym: "cyclic nucleotide activated ion channel activity" EXACT [] +synonym: "cyclic nucleotide gated ion channel activity" EXACT [] +synonym: "cyclic nucleotide-activated ion channel activity" EXACT [] +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0043856 +name: anti-sigma factor antagonist activity +namespace: molecular_function +def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, PMID:15576799] +subset: gosubset_prok +synonym: "anti-anti-sigma factor activity" EXACT [] +is_a: GO:0030528 ! transcription regulator activity + +[Term] +id: GO:0043857 +name: N-acetylornithine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline." [EC:2.1.3.9] +subset: gosubset_prok +synonym: "acetylornithine transcarbamylase activity" EXACT [] +synonym: "AOTC" RELATED [] +synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] +synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9] +synonym: "N-acetylornithine transcarbamylase activity" EXACT [] +xref: EC:2.1.3.9 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0043858 +name: arginine:ornithine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979] +subset: gosubset_prok +synonym: "ArcD" RELATED [] +synonym: "arginine-ornithine antiporter activity" EXACT [] +synonym: "arginine/ornithine antiporter" EXACT [] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0043859 +name: cyanophycinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200, UniProtKB:P58562] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +xref: EC:3.-.-.- +is_obsolete: true +replaced_by: GO:0008236 + +[Term] +id: GO:0043860 +name: cyanophycin synthetase activity +namespace: molecular_function +def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [GOC:jl, UniProtKB:P58572] +subset: gosubset_prok +synonym: "cphA" RELATED [] +xref: EC:6.-.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0043861 +name: agmatine:putrescine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272] +subset: gosubset_prok +synonym: "agmatine-putrescine antiporter activity" EXACT [] +synonym: "agmatine/putrescine antiporter" EXACT [] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0043862 +name: arginine:agmatine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215] +subset: gosubset_prok +synonym: "AdiC" RELATED [] +synonym: "arginine-agmatine antiporter activity" EXACT [] +synonym: "arginine-agmatine exchange transporter" EXACT [] +synonym: "arginine/agmatine antiporter activity" EXACT [] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0043863 +name: 4-hydroxy-2-ketopimelate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN, UniProtKB:Q46983] +subset: gosubset_prok +synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT [] +synonym: "HHED aldolase activity" EXACT [] +synonym: "HpaI" RELATED [] +synonym: "HpcH" RELATED [] +xref: EC:4.1.2.- +xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0043864 +name: indoleacetamide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetamide (IAM) + H2O = indole-3-acetate (IAA) + NH3." [GOC:jl, MetaCyc:RXNN-404, UniProtKB:Q04557] +subset: gosubset_prok +synonym: "IaaH" RELATED [] +synonym: "IAH" EXACT [] +synonym: "indole acetamide hydrolase activity" EXACT [] +synonym: "indole-3-acetamide hydrolase activity" EXACT [] +synonym: "Tms2" RELATED [] +xref: EC:3.5.1.- +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043865 +name: methionine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of methionine from one side of a membrane to the other." [GOC:jl] +subset: gosubset_prok +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity + +[Term] +id: GO:0043866 +name: adenylyl-sulfate reductase (thioredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10] +subset: gosubset_prok +synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [] +synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.10] +synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT [] +xref: EC:1.8.4.10 +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0043867 +name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, UniProtKB:Q9YAC2] +subset: gosubset_prok +synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT [] +synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT [] +synonym: "TgtA" RELATED [] +xref: EC:2.4.2.- +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0043868 +name: N-acetylaminoadipate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [PMID:10613839, UniProtKB:Q9V1I5] +subset: gosubset_prok +synonym: "acetylaminoadipate kinase activity" EXACT [] +synonym: "LysZ" RELATED [] +synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT [] +xref: EC:2.7.2.- +xref: MetaCyc:RXN-5182 +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0043869 +name: alpha-aminoadipate acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802] +subset: gosubset_prok +synonym: "lysine biosynthesis protein" RELATED [] +synonym: "LysX" RELATED [] +synonym: "RimK" RELATED [] +xref: MetaCyc:RXN-5181 +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0043870 +name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP(+) + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183, UniProtKB:Q9ZND6] +comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. +subset: gosubset_prok +synonym: "AGPR" RELATED [] +synonym: "ArgC" RELATED [] +synonym: "LysY" RELATED [] +synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT [] +synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT [] +synonym: "NAGSA dehydrogenase activity" BROAD [] +xref: EC:1.2.1.- +xref: MetaCyc:RXN-5183 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043871 +name: delta1-piperideine-6-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-pipecolate = delta1-piperideine-6-carboxylate + 2 H+." [MetaCyc:RXN-8161, PMID:16237033] +comment: This function is part of the pipecolate pathway of lysine catabolism. +subset: gosubset_prok +synonym: "AmaB" RELATED [] +synonym: "delta 1-piperideine-6-carboxylate dehydrogenase activity" EXACT [] +synonym: "delta-1-piperideine-6-carboxylate dehydrogenase activity" EXACT [] +synonym: "PIPOX" RELATED [] +xref: MetaCyc:RXN-8161 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043872 +name: lysine:cadaverine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, UniProtKB:P0AAF0] +subset: gosubset_prok +synonym: "CadB" RELATED [] +synonym: "lysine-cadaverine antiporter activity" EXACT [] +synonym: "lysine/cadaverine antiporter activity" EXACT [] +is_a: GO:0015300 ! solute:solute antiporter activity + +[Term] +id: GO:0043873 +name: pyruvate-flavodoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705, UniProtKB:Q3M8N0] +subset: gosubset_prok +synonym: "NifJ" RELATED [] +synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT [] +xref: EC:1.2.7.- +xref: MetaCyc:PYFLAVOXRE-RXN +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043874 +name: acireductone synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77] +comment: This function is involved in the process of methionine salvage. +subset: gosubset_prok +synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" EXACT [EC:3.1.3.77] +synonym: "E-1" RELATED [] +synonym: "E-1 enolase-phosphatase" BROAD [] +xref: EC:3.1.3.77 +xref: MetaCyc:3.1.3.77-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043875 +name: 2-ketobutyrate formate-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901] +comment: This function is part of an anaerobic pathway for the catabolism of L-threonine. +subset: gosubset_prok +synonym: "keto-acid formate acetyltransferase" BROAD [] +synonym: "KFL" EXACT [] +synonym: "TdcE" RELATED [] +xref: EC:2.3.1- +xref: MetaCyc:KETOBUTFORMLY-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0043876 +name: D-threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [PMID:9642221, UniProtKB:A2SCK2] +subset: gosubset_prok +synonym: "D-allo-TA" EXACT [] +synonym: "D-allo-threonine aldolase activity" EXACT [] +synonym: "D-TA" EXACT [] +synonym: "DtaAS" RELATED [] +synonym: "low-specificity D-threonine aldolase" NARROW [] +xref: EC:4.1.2.- +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0043877 +name: galactosamine-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [UniProtKB:P42912] +comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization. +subset: gosubset_prok +synonym: "AgaI" RELATED [] +synonym: "galactosamine-6-phosphate deaminase activity" EXACT [] +xref: EC:5.3.1.- +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0043878 +name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334] +subset: gosubset_prok +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT [] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT [] +synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT [] +xref: EC:1.2.1.- +is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity + +[Term] +id: GO:0043879 +name: glycolate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [GOC:jl, http://en.wikipedia.org/, UniProtKB:Q46839] +subset: gosubset_prok +synonym: "glcA" RELATED [] +synonym: "glycolate permease" RELATED [] +synonym: "glycolic acid transmembrane transporter activity" EXACT [] +synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0043880 +name: crotonyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [IPR:IPR010085, PMID:11162231, UniProtKB:A1B8U5] +subset: gosubset_prok +synonym: "CCR" EXACT [] +synonym: "crotonyl-coenzyme A reductase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043881 +name: mesaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937] +comment: This function is part of an alternate glyoxylate cycle for acetate assimilation. +subset: gosubset_prok +synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT [] +synonym: "mch" RELATED [] +synonym: "mesaconyl-coenzyme A hydratase activity" EXACT [] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043882 +name: malate:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, UniProtKB:O05256] +subset: gosubset_prok +synonym: "malate Na(+) symporter" EXACT [] +synonym: "malate-sodium symporter activity" EXACT [] +synonym: "malate/sodium cotransporter activity" EXACT [] +synonym: "malate/sodium symporter activity" EXACT [] +synonym: "malate:Na+ symporter activity" EXACT [] +synonym: "malate:sodium cotransporter activity" EXACT [] +synonym: "Na(+)-malate symporter" EXACT [] +synonym: "Na+:malate symporter activity" EXACT [] +synonym: "sodium-dependent malate transporter" BROAD [] +synonym: "sodium/malate symporter activity" EXACT [] +synonym: "sodium:malate symporter activity" EXACT [] +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0043883 +name: malolactic enzyme activity +namespace: molecular_function +def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053] +comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria. +subset: gosubset_prok +synonym: "MleS" RELATED [] +xref: EC:1.-.-.- +xref: MetaCyc:RXN8E-5623 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043884 +name: CO-methylating acetyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656] +subset: gosubset_prok +synonym: "acetyl-CoA synthase activity" BROAD [] +synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT [] +synonym: "ACS" RELATED [EC:2.3.1.169] +synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT [] +xref: EC:2.3.1.169 +xref: MetaCyc:ACETYLSYNCLTH-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0043885 +name: carbon-monoxide dehydrogenase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4] +subset: gosubset_prok +synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT [] +synonym: "carbon monoxide dehydrogenase activity" BROAD [] +synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4] +synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT [] +synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT [] +synonym: "CO dehydrogenase activity" EXACT [] +synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT [] +synonym: "CO-dehydrogenase activity" EXACT [] +synonym: "CODH" RELATED [] +xref: EC:1.2.7.4 +xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043886 +name: structural constituent of carboxysome +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0043887 +name: melibiose:sodium symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646, UniProtKB:P02921] +subset: gosubset_prok +synonym: "MelB" RELATED [] +synonym: "melibiose carrier protein" RELATED [] +synonym: "melibiose permease" BROAD [] +synonym: "melibiose-Na+ symporter activity" EXACT [] +synonym: "melibiose-sodium symporter activity" EXACT [] +synonym: "melibiose/Na+ symporter activity" EXACT [] +synonym: "melibiose/sodium symporter activity" EXACT [] +synonym: "melibiose:Na+ symporter activity" EXACT [] +synonym: "Na+ (Li+)/melibiose symporter" EXACT [] +synonym: "Na+-melibiose symporter activity" EXACT [] +synonym: "Na+/melibiose symporter activity" EXACT [] +synonym: "Na+:melibiose symporter activity" EXACT [] +synonym: "sodium-melibiose symporter activity" EXACT [] +synonym: "sodium/melibiose symporter activity" EXACT [] +synonym: "sodium:melibiose symporter activity" EXACT [] +synonym: "thiomethylgalactoside permease II" RELATED [] +is_a: GO:0015487 ! melibiose:monovalent cation symporter activity + +[Term] +id: GO:0043888 +name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480] +comment: This function is involved in archaeal lipid synthesis. +subset: gosubset_prok +synonym: "2,3-dGGGPS" EXACT [] +synonym: "DGGGP synthase activity" EXACT [] +synonym: "DGGGPS" EXACT [] +synonym: "UbiA" RELATED [] +xref: EC:2.5.1.- +is_a: GO:0002094 ! polyprenyltransferase activity +is_a: GO:0004337 ! geranyltranstransferase activity + +[Term] +id: GO:0043889 +name: (S)-3-O-geranylgeranylglyceryl phosphate activity +namespace: molecular_function +def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023] +comment: This function is involved in archaeal lipid synthesis. +subset: gosubset_prok +synonym: "(S)-3-O-geranylgeranylglycerylphosphate activity" EXACT [] +synonym: "(S)-GGGP synthase activity" EXACT [] +synonym: "GGGP synthase activity" EXACT [] +synonym: "GGGPS" EXACT [] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0043890 +name: N-acetylgalactosamine-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4] +subset: gosubset_prok +synonym: "acetylgalactosamine 6-sulfatase activity" EXACT [] +synonym: "chondroitin sulfatase" BROAD [] +synonym: "chondroitinase" BROAD [] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4] +synonym: "galactose-6-sulfate sulfatase activity" EXACT [] +synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [] +synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT [] +synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT [] +xref: EC:3.1.6.4 +xref: MetaCyc:3.1.6.4-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0043891 +name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59] +subset: gosubset_prok +synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT [] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT [] +synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.59] +synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT [] +synonym: "triosephosphate dehydrogenase (NAD(P)+)" EXACT [EC:1.2.1.59] +xref: EC:1.2.1.59 +xref: MetaCyc:GAPDHSYNEC-RXN +is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity + +[Term] +id: GO:0043892 +name: methylglyoxal reductase (NADPH-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283] +subset: gosubset_prok +synonym: "Gre2" RELATED [] +synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT [] +synonym: "lactaldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.283] +xref: EC:1.1.1.283 +xref: MetaCyc:1.1.1.283-RXN +xref: MetaCyc:RXN-8636 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043893 +name: acetate:cation symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl] +subset: gosubset_prok +synonym: "acetate permease" BROAD [] +synonym: "acetate-cation symporter activity" EXACT [] +synonym: "acetate/cation symporter activity" EXACT [] +synonym: "ActP" RELATED [] +synonym: "cation-acetate symporter activity" EXACT [] +synonym: "cation/acetate symporter activity" EXACT [] +synonym: "cation:acetate symporter activity" EXACT [] +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0043894 +name: acetyl-CoA synthetase acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963] +subset: gosubset_prok +synonym: "Pat" EXACT [] +synonym: "Pat enzyme" EXACT [] +synonym: "protein acetyltransferase activity" BROAD [] +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0043895 +name: cyclomaltodextrin glucanotransferase activity +namespace: molecular_function +def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19] +synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT [] +synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED [] +synonym: "alpha-cyclodextrin glucanotransferase" RELATED [] +synonym: "alpha-cyclodextrin glycosyltransferase" RELATED [] +synonym: "Bacillus macerans amylase" RELATED [] +synonym: "beta-cyclodextrin glucanotransferase" RELATED [] +synonym: "beta-cyclodextrin glycosyltransferase" RELATED [] +synonym: "BMA" RELATED [] +synonym: "CGTase" RELATED [] +synonym: "cyclodextrin glucanotransferase" BROAD [] +synonym: "cyclodextrin glycosyltransferase" RELATED [] +synonym: "cyclomaltodextrin glucotransferase" RELATED [] +synonym: "cyclomaltodextrin glycosyltransferase" RELATED [] +synonym: "gamma-cyclodextrin glycosyltransferase" RELATED [] +synonym: "konchizaimu" RELATED [] +synonym: "neutral-cyclodextrin glycosyltransferase" RELATED [] +xref: EC:2.4.1.19 +xref: MetaCyc:2.4.1.19-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0043896 +name: glucan 1,6-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70] +subset: gosubset_prok +synonym: "exo-1,6-alpha-glucosidase activity" EXACT [EC:3.2.1.70] +synonym: "exo-1,6-beta-glucosidase" RELATED [] +synonym: "glucan alpha-1,6-D-glucohydrolase activity" EXACT [EC:3.2.1.70] +synonym: "glucan-1,6-alpha-glucosidase activity" EXACT [] +synonym: "glucodextranase activity" EXACT [EC:3.2.1.70] +synonym: "glucodextrinase" BROAD [] +xref: EC:3.2.1.70 +xref: MetaCyc:3.2.1.70-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0043897 +name: glucan 1,4-alpha-maltohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133] +subset: gosubset_prok +synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT [] +synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT [] +synonym: "maltogenic alpha-amylase activity" EXACT [] +xref: EC:3.2.1.133 +xref: MetaCyc:3.2.1.133-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0043898 +name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866] +subset: gosubset_prok +synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT [] +synonym: "BphC" RELATED [] +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0043899 +name: phosphoserine:homoserine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121] +subset: gosubset_prok +synonym: "thrH" RELATED [] +xref: EC:2.7.1.- +xref: IMG:02616 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043900 +name: regulation of multi-organism process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process by which an organism has an effect on another organism of the same or different species." [GOC:jl] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0051704 ! multi-organism process + +[Term] +id: GO:0043901 +name: negative regulation of multi-organism process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a multi-organism process, a process by which an organism has an effect on another organism of the same or different species." [GOC:jl] +is_a: GO:0043900 ! regulation of multi-organism process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0051704 ! multi-organism process + +[Term] +id: GO:0043902 +name: positive regulation of multi-organism process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process by which an organism has an effect on another organism of the same or different species." [GOC:jl] +is_a: GO:0043900 ! regulation of multi-organism process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0051704 ! multi-organism process + +[Term] +id: GO:0043903 +name: regulation of symbiosis, encompassing mutualism through parasitism +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0043904 +name: isochorismate pyruvate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620] +subset: gosubset_prok +synonym: "IPL" EXACT [] +synonym: "isochorismate-pyruvate lyase activity" EXACT [] +xref: EC:4.1.3.- +xref: IMG:02661 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0043905 +name: Ser-tRNA(Thr) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874] +subset: gosubset_prok +synonym: "Ser-tRNAThr hydrolase activity" EXACT [] +xref: EC:3.1.1.- +xref: IMG:02667 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0043906 +name: Ala-tRNA(Pro) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147] +subset: gosubset_prok +synonym: "Ala-tRNAPro hydrolase activity" EXACT [] +xref: EC:3.1.1.- +xref: IMG:02668 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0043907 +name: Cys-tRNA(Pro) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196] +subset: gosubset_prok +synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT [] +synonym: "Cys-tRNAPro hydrolase activity" EXACT [] +xref: EC:3.1.1.- +xref: IMG:02669 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0043908 +name: Ser(Gly)-tRNA(Ala) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147] +subset: gosubset_prok +synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT [] +xref: EC:3.1.1.- +xref: IMG:02670 +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0043909 +name: N-acetylcitrulline deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O => citrulline + acetate." [GOC:jl, IMG:02799, PMID:16750290] +subset: gosubset_prok +synonym: "acetylcitrulline deacetylase activity" EXACT [] +synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT [] +xref: EC:3.5.1.- +xref: IMG:02799 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043910 +name: coenzyme F390 synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme F420 + ATP = coenzyme F390." [GOC:jl, IMG:02803, PMID:7957247, PMID:8550473] +subset: gosubset_prok +synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT [] +xref: EC:2.7.7.- +xref: IMG:02803 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0043911 +name: D-lysine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, IMG:02956, PMID:17259313] +subset: gosubset_prok +synonym: "D-lysine aminotransferase activity" EXACT [] +xref: EC:2.6.1.- +xref: IMG:02956 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043912 +name: D-lysine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2." [GOC:jl, IMG:02957, PMID:17259313] +subset: gosubset_prok +xref: EC:1.4.3.- +xref: IMG:02957 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0043913 +name: chromosome segregation-directing complex +namespace: cellular_component +def: "A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918] +subset: gosubset_prok +synonym: "chromosome segregation directing complex" EXACT [] +synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT [] +synonym: "MreBCD complex" NARROW [] +xref: IMG:02994 +is_a: GO:0043234 ! protein complex +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0043914 +name: NADPH:sulfur oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + S0 = H2S + NADP." [GOC:jl, PMID:17449625] +subset: gosubset_prok +synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] +synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT [] +synonym: "NADPH:sulphur oxidoreductase activity" EXACT [] +synonym: "NSR" EXACT [] +xref: EC:1.-.-.- +xref: IMG:03008 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043915 +name: L-seryl-tRNA(Sec) kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, IMG:03019, UniProtKB:Q8IV42] +subset: gosubset_prok +synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT [] +xref: EC:2.7.1.- +xref: IMG:03019 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043916 +name: DNA-7-methylguanine glycosylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes the alkylated base 7-methylguanine." [GOC:jl, PMID:16468998] +subset: gosubset_prok +xref: EC:3.2.2.- +xref: IMG:03021 +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0043917 +name: ribose 1,5-bisphosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl, IMG:03024] +subset: gosubset_prok +synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT [] +xref: EC:5.3.1.- +xref: IMG:03024 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0043918 +name: cadaverine aminopropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, IMG:00522, PMID:17545282] +subset: gosubset_prok +synonym: "cadaverine aminopropyl transferase activity" EXACT [] +xref: EC:2.5.1.- +xref: IMG:00522 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0043919 +name: agmatine aminopropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, IMG:03077, PMID:15983049] +subset: gosubset_prok +synonym: "agmatine aminopropyl transferase activity" EXACT [] +xref: EC:2.5.1.- +xref: IMG:03077 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0043920 +name: aminopropylagmatine ureohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, IMG:03079, PMID:15983049] +subset: gosubset_prok +xref: EC:3.5.3.- +xref: IMG:03079 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0043921 +name: modulation by host of viral transcription +namespace: biological_process +def: "Any process by which a host organism modulates the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] +synonym: "regulation by host of viral transcription" EXACT [] +synonym: "regulation of viral transcription by host " EXACT [] +is_a: GO:0052472 ! modulation by host of symbiont transcription + +[Term] +id: GO:0043922 +name: negative regulation by host of viral transcription +namespace: biological_process +def: "Any process by which a host organism stops, prevents or reduces the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] +synonym: "negative regulation of viral transcription by host" EXACT [] +is_a: GO:0016481 ! negative regulation of transcription +is_a: GO:0043921 ! modulation by host of viral transcription + +[Term] +id: GO:0043923 +name: positive regulation by host of viral transcription +namespace: biological_process +def: "Any process by which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] +synonym: "positive regulation of viral transcription by host" EXACT [] +is_a: GO:0043921 ! modulation by host of viral transcription +is_a: GO:0045941 ! positive regulation of transcription + +[Term] +id: GO:0043924 +name: suramin binding +namespace: molecular_function +def: "Interacting selectively with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [CHEBI:45906, GOC:jl, http://en.wikipedia.org/wiki/Suramin] +synonym: "Germanin binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043925 +name: microtubule-associated DASH complex +namespace: cellular_component +def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex associates with microtubules and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:mtg_mpo, PMID:11782438, PMID:11799062] +comment: Note that this complex is conserved in fungi but has not been observed in metazoans. +is_a: GO:0005875 ! microtubule associated complex +is_a: GO:0042729 ! DASH complex +relationship: part_of GO:0005828 ! kinetochore microtubule + +[Term] +id: GO:0043926 +name: kinetochore-associated DASH complex +namespace: cellular_component +def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex associates with kinetochores and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:mtg_mpo, PMID:11782438, PMID:11799062] +comment: Note that this complex is conserved in fungi but has not been observed in metazoans. +synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT [] +is_a: GO:0042729 ! DASH complex +is_a: GO:0044454 ! nuclear chromosome part +relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore + +[Term] +id: GO:0043927 +name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic +relationship: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay + +[Term] +id: GO:0043928 +name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic +relationship: part_of GO:0000290 ! deadenylation-dependent decapping of nuclear-transcribed mRNA + +[Term] +id: GO:0043929 +name: primary ovarian follicle growth during double layer follicle stage +namespace: biological_process +def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), during the double layer follicle stage of oogenesis." [GOC:mtg_mpo] +is_a: GO:0001545 ! primary ovarian follicle growth +relationship: part_of GO:0048161 ! double layer follicle stage, oogenesis + +[Term] +id: GO:0043930 +name: primary ovarian follicle growth during primary follicle stage +namespace: biological_process +def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) during the primary follicle stage of oogenesis." [GOC:mtg_mpo] +is_a: GO:0001545 ! primary ovarian follicle growth +relationship: part_of GO:0048160 ! primary follicle stage, oogenesis + +[Term] +id: GO:0043931 +name: ossification involved in bone morphogenesis +namespace: biological_process +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone involved in the progression of the skeleton from its formation to its mature state." [GOC:mtg_mpo] +synonym: "ossification involved in skeletal development" EXACT [GOC:dph] +is_a: GO:0001503 ! ossification +relationship: part_of GO:0060349 ! bone morphogenesis + +[Term] +id: GO:0043932 +name: ossification involved in bone remodeling +namespace: biological_process +def: "The formation of bone involved in the continuous turnover of bone matrix and mineral." [GOC:mtg_mpo] +synonym: "ossification involved in bone remodelling" RELATED [] +is_a: GO:0001503 ! ossification +relationship: part_of GO:0046849 ! bone remodeling + +[Term] +id: GO:0043933 +name: macromolecular complex subunit organization +namespace: biological_process +alt_id: GO:0034600 +def: "Any process by which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mtg_mpo] +subset: gosubset_prok +synonym: "macromolecular complex organization" EXACT [] +synonym: "macromolecular complex subunit organisation" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043934 +name: sporulation +namespace: biological_process +def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0043935 +name: sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_08] +is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore +is_a: GO:0034293 ! sexual sporulation + +[Term] +id: GO:0043936 +name: asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_08] +is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore +is_a: GO:0030436 ! asexual sporulation + +[Term] +id: GO:0043937 +name: regulation of sporulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0043934 ! sporulation + +[Term] +id: GO:0043938 +name: positive regulation of sporulation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0043934 ! sporulation + +[Term] +id: GO:0043939 +name: negative regulation of sporulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0043934 ! sporulation + +[Term] +id: GO:0043940 +name: regulation of sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_08] +is_a: GO:0034306 ! regulation of sexual sporulation +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043941 +name: positive regulation of sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_08] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043942 +name: negative regulation of sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_08] +is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043943 +name: regulation of asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_08] +is_a: GO:0034305 ! regulation of asexual sporulation +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043944 +name: negative regulation of asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_08] +is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043945 +name: positive regulation of asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_08] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043946 +name: positive regulation of catalytic activity in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "activation of enzyme activity in other organism" NARROW [] +synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0052203 ! modification of catalytic activity in other organism during symbiotic interaction +is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0043947 +name: positive regulation by host of symbiont enzyme activity +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_08] +synonym: "activation by host of symbiont enzyme activity" NARROW [] +synonym: "activation of symbiont enzyme activity" NARROW [] +synonym: "up regulation by host of symbiont enzyme activity" EXACT [] +synonym: "up-regulation by host of symbiont enzyme activity" EXACT [] +synonym: "upregulation by host of symbiont enzyme activity" EXACT [] +is_a: GO:0043946 ! positive regulation of catalytic activity in other organism during symbiotic interaction +is_a: GO:0052405 ! negative regulation by host of symbiont molecular function +is_a: GO:0052422 ! modification by host of symbiont catalytic activity + +[Term] +id: GO:0043948 +name: positive regulation by symbiont of host enzyme activity +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host enzyme activity" NARROW [] +synonym: "activation of host enzyme activity" NARROW [] +synonym: "up regulation by symbiont of host enzyme activity" EXACT [] +synonym: "up-regulation by symbiont of host enzyme activity" EXACT [] +synonym: "upregulation by symbiont of host enzyme activity" EXACT [] +is_a: GO:0043946 ! positive regulation of catalytic activity in other organism during symbiotic interaction +is_a: GO:0052056 ! negative regulation by symbiont of host molecular function +is_a: GO:0052148 ! modification by symbiont of host catalytic activity + +[Term] +id: GO:0043949 +name: regulation of cAMP-mediated signaling +namespace: biological_process +def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] +synonym: "regulation of cAMP-mediated signalling" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0043950 +name: positive regulation of cAMP-mediated signaling +namespace: biological_process +def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] +synonym: "positive regulation of cAMP-mediated signalling" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0043951 +name: negative regulation of cAMP-mediated signaling +namespace: biological_process +def: "Any process which stops, prevents or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] +synonym: "negative regulation of cAMP-mediated signalling" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0043952 +name: protein transport by the Sec complex +namespace: biological_process +def: "The process by which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'protein secretion by the Type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. +synonym: "protein secretion by the Sec complex" NARROW [] +synonym: "protein translocation by the Sec complex" NARROW [] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0043953 +name: protein transport by the Tat complex +namespace: biological_process +def: "The process by which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. +subset: gosubset_prok +synonym: "protein secretion by the TAT complex" NARROW [] +synonym: "protein translocation by the TAT complex" NARROW [] +synonym: "protein translocation by the Twin-arginine translocation complex" NARROW [] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0043954 +name: cellular component maintenance +namespace: biological_process +def: "The organization process by which a cellular component is preserved in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043955 +name: 3-hydroxypropionyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + pyrophosphate." [GOC:jl, PMID:11821399] +comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. +subset: gosubset_prok +synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT [] +synonym: "acetyl-coenzyme A synthetase" BROAD [] +synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW [] +synonym: "AMP-dependent synthetase and ligase" BROAD [] +synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] +synonym: "enoyl-CoA hydratase/isomerase" BROAD [] +xref: EC:6.2.1.- +xref: IMG:03293 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0043956 +name: 3-hydroxypropionyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O." [GOC:jl, PMID:11821399] +comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. +subset: gosubset_prok +synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT [] +synonym: "acetyl-coenzyme A synthetase" BROAD [] +synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] +synonym: "AMP-dependent synthetase and ligase" BROAD [] +synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] +synonym: "enoyl-CoA hydratase/isomerase" BROAD [] +xref: EC:4.2.1.- +xref: IMG:03294 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043957 +name: acrylyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acrylyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399] +comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. +subset: gosubset_prok +synonym: "acetyl-coenzyme A synthetase" BROAD [] +synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] +synonym: "AMP-dependent synthetase and ligase" BROAD [] +synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD [] +synonym: "enoyl-CoA hydratase/isomerase" BROAD [] +xref: EC:1.3.1.- +xref: IMG:03302 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043958 +name: acryloyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced electron transferring flavoprotein + NADH + acrylyl-CoA = NAD+ + oxidized electron transferring flavoprotein + propionyl-CoA." [GOC:jl, PMID:12603323] +comment: Note that this function is part of the process of L-alanine fermentation to propionate. +subset: gosubset_prok +synonym: "acryloyl-coenzyme A reductase activity" EXACT [] +synonym: "acrylyl-CoA reductase (NADH)" EXACT [] +synonym: "propionyl-CoA dehydrogenase" EXACT [] +xref: EC:1.3.1.- +xref: IMG:01636 +xref: MetaCyc:CPLX-7247 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043959 +name: L-erythro-3-methylmalyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl, IMG:03303] +subset: gosubset_prok +synonym: "HpcH/HpaI aldolase" RELATED [] +xref: EC:4.1.3.- +xref: IMG:03303 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0043960 +name: L-erythro-3-methylmalyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl, IMG:03304] +subset: gosubset_prok +xref: EC:4.2.1.- +xref: IMG:03304 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043961 +name: succinyl-CoA:(R)-citramalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, IMG:03306, PMID:17259315] +subset: gosubset_prok +synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED [] +synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT [] +synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT [] +xref: EC:2.8.3.- +xref: IMG:03306 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0044000 +name: movement within host +namespace: biological_process +def: "The process by which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051814 ! movement within other organism during symbiotic interaction +is_a: GO:0052126 ! movement in host environment + +[Term] +id: GO:0044001 +name: migration within host +namespace: biological_process +def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044000 ! movement within host +is_a: GO:0051815 ! migration within other organism during symbiotic interaction + +[Term] +id: GO:0044002 +name: acquisition of nutrients from host +namespace: biological_process +def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051701 ! interaction with host +is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction + +[Term] +id: GO:0044003 +name: modification by symbiont of host morphology or physiology +namespace: biological_process +def: "The process by which an organism effects a change in the structure or processes of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051701 ! interaction with host +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0044004 +name: disruption by symbiont of host cells +namespace: biological_process +def: "Any process by which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "disruption by organism of host cells" EXACT [] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0051818 ! disruption of cells of other organism during symbiotic interaction + +[Term] +id: GO:0044005 +name: induction by symbiont in host of tumor, nodule, or growth +namespace: biological_process +def: "The process by which an organism causes the formation of an abnormal mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism during symbiotic interaction + +[Term] +id: GO:0044006 +name: induction by symbiont in host of tumor, nodule, or growth containing transformed cells +namespace: biological_process +def: "The process by which an organism causes the formation in its host organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +is_a: GO:0044005 ! induction by symbiont in host of tumor, nodule, or growth +is_a: GO:0051820 ! induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction + +[Term] +id: GO:0044007 +name: dissemination or transmission of symbiont from host +namespace: biological_process +def: "The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "dissemination or transmission of organism from host" EXACT [] +is_a: GO:0051701 ! interaction with host +is_a: GO:0051821 ! dissemination or transmission of organism from other organism during symbiotic interaction + +[Term] +id: GO:0044008 +name: dissemination or transmission of symbiont from host by vector +namespace: biological_process +def: "The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "dissemination or transmission of organism from host by vector" EXACT [] +is_a: GO:0044007 ! dissemination or transmission of symbiont from host +is_a: GO:0051822 ! dissemination or transmission of organism from other organism by vector during symbiotic interaction + +[Term] +id: GO:0044009 +name: viral transmission by vector +namespace: biological_process +def: "The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc] +is_a: GO:0019089 ! transmission of virus +is_a: GO:0044008 ! dissemination or transmission of symbiont from host by vector + +[Term] +id: GO:0044010 +name: single-species biofilm formation +namespace: biological_process +def: "A process whereby microorganisms of the same species attach to and grow on a surface such, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] +subset: gosubset_prok +is_a: GO:0042710 ! biofilm formation + +[Term] +id: GO:0044011 +name: single-species biofilm formation on inanimate substrate +namespace: biological_process +def: "A process whereby microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044010 ! single-species biofilm formation +is_a: GO:0051703 ! intraspecies interaction between organisms + +[Term] +id: GO:0044236 +name: multicellular organismal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators] +synonym: "multicellular organismal metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0044237 +name: cellular metabolic process +namespace: biological_process +def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +synonym: "cellular metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0044238 +name: primary metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +synonym: "primary metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0044239 +name: salivary polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/] +synonym: "salivary polysaccharide breakdown" EXACT [] +synonym: "salivary polysaccharide catabolism" EXACT [] +synonym: "salivary polysaccharide degradation" EXACT [] +is_a: GO:0044244 ! multicellular organismal polysaccharide catabolic process + +[Term] +id: GO:0044240 +name: multicellular organismal lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl] +synonym: "organismal lipid breakdown" EXACT [] +synonym: "organismal lipid catabolism" EXACT [] +synonym: "organismal lipid degradation" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0044243 ! multicellular organismal catabolic process +relationship: part_of GO:0044241 ! lipid digestion + +[Term] +id: GO:0044241 +name: lipid digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] +xref: Reactome:192456 +xref: Reactome:211764 +xref: Reactome:221531 +xref: Reactome:230146 +xref: Reactome:238173 +xref: Reactome:244763 +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0044242 +name: cellular lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular lipid breakdown" EXACT [] +synonym: "cellular lipid catabolism" EXACT [] +synonym: "cellular lipid degradation" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0044243 +name: multicellular organismal catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators] +synonym: "organismal breakdown" EXACT [] +synonym: "organismal catabolism" EXACT [] +synonym: "organismal degradation" EXACT [] +is_a: GO:0044236 ! multicellular organismal metabolic process + +[Term] +id: GO:0044244 +name: multicellular organismal polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl] +synonym: "organismal polysaccharide breakdown" EXACT [] +synonym: "organismal polysaccharide catabolism" EXACT [] +synonym: "organismal polysaccharide degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0044263 ! multicellular organismal polysaccharide metabolic process +is_a: GO:0044276 ! multicellular organismal carbohydrate catabolic process +relationship: part_of GO:0044245 ! polysaccharide digestion + +[Term] +id: GO:0044245 +name: polysaccharide digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] +xref: Reactome:189085 +xref: Reactome:211763 +xref: Reactome:221530 +xref: Reactome:230145 +xref: Reactome:238172 +xref: Reactome:244762 +xref: Reactome:249668 +xref: Reactome:252519 +xref: Reactome:255698 +xref: Reactome:258995 +xref: Reactome:262365 +xref: Reactome:265284 +xref: Reactome:268373 +xref: Reactome:274033 +xref: Reactome:280511 +xref: Reactome:282804 +xref: Reactome:286533 +xref: Reactome:289810 +xref: Reactome:291731 +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0044246 +name: regulation of multicellular organismal metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:go_curators, GOC:tb] +synonym: "regulation of organismal metabolic process" EXACT [GOC:tb] +synonym: "regulation of organismal metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0044236 ! multicellular organismal metabolic process + +[Term] +id: GO:0044247 +name: cellular polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular polysaccharide breakdown" EXACT [] +synonym: "cellular polysaccharide catabolism" EXACT [] +synonym: "cellular polysaccharide degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0044248 +name: cellular catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular breakdown" EXACT [] +synonym: "cellular catabolism" EXACT [] +synonym: "cellular degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044249 +name: cellular biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular anabolism" EXACT [] +synonym: "cellular biosynthesis" EXACT [] +synonym: "cellular formation" EXACT [] +synonym: "cellular synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044250 +name: negative regulation of metabolic activity during hibernation +namespace: biological_process +def: "The slowing of metabolic processes to very low levels in order to conserve energy during hibernation." [GOC:jl, http://en.wikipedia.org/] +synonym: "down regulation of metabolic activity during hibernation" EXACT [] +synonym: "down-regulation of metabolic activity during hibernation" EXACT [] +synonym: "downregulation of metabolic activity during hibernation" EXACT [] +synonym: "inhibition of metabolic activity during hibernation" NARROW [] +is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process +relationship: part_of GO:0042750 ! hibernation + +[Term] +id: GO:0044251 +name: protein catabolic process by pepsin +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/] +synonym: "protein breakdown by pepsin" EXACT [] +synonym: "protein degradation by pepsin" EXACT [] +is_a: GO:0044254 ! multicellular organismal protein catabolic process + +[Term] +id: GO:0044252 +name: negative regulation of multicellular organismal metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl] +synonym: "down regulation of organismal metabolic process" EXACT [] +synonym: "down-regulation of organismal metabolic process" EXACT [] +synonym: "downregulation of organismal metabolic process" EXACT [] +synonym: "inhibition of organismal metabolic process" NARROW [] +synonym: "negative regulation of organismal metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0044246 ! regulation of multicellular organismal metabolic process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0044236 ! multicellular organismal metabolic process + +[Term] +id: GO:0044253 +name: positive regulation of multicellular organismal metabolic process +namespace: biological_process +def: "Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl] +synonym: "activation of organismal metabolic process" NARROW [] +synonym: "positive regulation of organismal metabolism" EXACT [] +synonym: "stimulation of organismal metabolic process" NARROW [] +synonym: "up regulation of organismal metabolic process" EXACT [] +synonym: "up-regulation of organismal metabolic process" EXACT [] +synonym: "upregulation of organismal metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0044246 ! regulation of multicellular organismal metabolic process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0044236 ! multicellular organismal metabolic process + +[Term] +id: GO:0044254 +name: multicellular organismal protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal protein breakdown" EXACT [] +synonym: "organismal protein catabolism" EXACT [] +synonym: "organismal protein degradation" EXACT [] +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0044243 ! multicellular organismal catabolic process +is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process +is_a: GO:0044268 ! multicellular organismal protein metabolic process +relationship: part_of GO:0044256 ! protein digestion + +[Term] +id: GO:0044255 +name: cellular lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +synonym: "cellular lipid metabolism" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044256 +name: protein digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0044257 +name: cellular protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular protein breakdown" EXACT [] +synonym: "cellular protein catabolism" EXACT [] +synonym: "cellular protein degradation" EXACT [] +xref: Reactome:174731 +xref: Reactome:207150 +xref: Reactome:216723 +xref: Reactome:225605 +xref: Reactome:234256 +xref: Reactome:242004 +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0044258 +name: intestinal lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/] +synonym: "intestinal lipid breakdown" EXACT [] +synonym: "intestinal lipid catabolism" EXACT [] +synonym: "intestinal lipid degradation" EXACT [] +is_a: GO:0044240 ! multicellular organismal lipid catabolic process + +[Term] +id: GO:0044259 +name: multicellular organismal macromolecule metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal macromolecule metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044236 ! multicellular organismal metabolic process + +[Term] +id: GO:0044260 +name: cellular macromolecule metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [ChEBI:33839, GOC:mah] +subset: gosubset_prok +synonym: "cellular macromolecule metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044261 +name: multicellular organismal carbohydrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal carbohydrate metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process + +[Term] +id: GO:0044262 +name: cellular carbohydrate metabolic process +namespace: biological_process +alt_id: GO:0006092 +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular carbohydrate metabolism" EXACT [] +synonym: "main pathways of carbohydrate metabolic process" NARROW [] +synonym: "main pathways of carbohydrate metabolism" NARROW [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044263 +name: multicellular organismal polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal glycan metabolic process" EXACT [] +synonym: "organismal glycan metabolism" EXACT [] +synonym: "organismal polysaccharide metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process +is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process + +[Term] +id: GO:0044264 +name: cellular polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular glycan metabolic process" EXACT [] +synonym: "cellular glycan metabolism" EXACT [] +synonym: "cellular polysaccharide metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process +is_a: GO:0034960 ! cellular biopolymer metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0044265 +name: cellular macromolecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular macromolecule breakdown" EXACT [] +synonym: "cellular macromolecule catabolism" EXACT [] +synonym: "cellular macromolecule degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0044266 +name: multicellular organismal macromolecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal macromolecule breakdown" EXACT [] +synonym: "organismal macromolecule catabolism" EXACT [] +synonym: "organismal macromolecule degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process + +[Term] +id: GO:0044267 +name: cellular protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification." [GOC:jl] +subset: gosubset_prok +synonym: "cellular protein metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0044268 +name: multicellular organismal protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal protein metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process + +[Term] +id: GO:0044269 +name: glycerol ether catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl] +subset: gosubset_prok +synonym: "glycerol ether breakdown" EXACT [] +synonym: "glycerol ether catabolism" EXACT [] +synonym: "glycerol ether degradation" EXACT [] +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0044270 +name: nitrogen compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cellular nitrogen compound catabolic process" EXACT [] +synonym: "nitrogen compound breakdown" EXACT [] +synonym: "nitrogen compound catabolism" EXACT [] +synonym: "nitrogen compound degradation" EXACT [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0044271 +name: nitrogen compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cellular nitrogen compound biosynthetic process" EXACT [] +synonym: "nitrogen compound anabolism" EXACT [] +synonym: "nitrogen compound biosynthesis" EXACT [] +synonym: "nitrogen compound formation" EXACT [] +synonym: "nitrogen compound synthesis" EXACT [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0044272 +name: sulfur compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] +subset: gosubset_prok +synonym: "sulfur biosynthesis" NARROW [] +synonym: "sulfur biosynthetic process" NARROW [] +synonym: "sulfur compound anabolism" EXACT [] +synonym: "sulfur compound biosynthesis" EXACT [] +synonym: "sulfur compound formation" EXACT [] +synonym: "sulfur compound synthesis" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0044273 +name: sulfur compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] +subset: gosubset_prok +synonym: "sulfur catabolic process" NARROW [] +synonym: "sulfur catabolism" NARROW [] +synonym: "sulfur compound breakdown" EXACT [] +synonym: "sulfur compound catabolism" EXACT [] +synonym: "sulfur compound degradation" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0044274 +name: multicellular organismal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal anabolism" EXACT [] +synonym: "organismal biosynthesis" EXACT [] +synonym: "organismal formation" EXACT [] +synonym: "organismal synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process + +[Term] +id: GO:0044275 +name: cellular carbohydrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] +subset: gosubset_prok +synonym: "cellular carbohydrate breakdown" EXACT [] +synonym: "cellular carbohydrate catabolism" EXACT [] +synonym: "cellular carbohydrate degradation" EXACT [] +is_a: GO:0016052 ! carbohydrate catabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0044276 +name: multicellular organismal carbohydrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl] +synonym: "organismal carbohydrate breakdown" EXACT [] +synonym: "organismal carbohydrate catabolism" EXACT [] +synonym: "organismal carbohydrate degradation" EXACT [] +is_a: GO:0016052 ! carbohydrate catabolic process +is_a: GO:0044243 ! multicellular organismal catabolic process +is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process +is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process + +[Term] +id: GO:0044399 +name: multi-species biofilm formation +namespace: biological_process +def: "A process whereby microorganisms of different species attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] +subset: gosubset_prok +is_a: GO:0042710 ! biofilm formation +is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0044400 +name: multi-species biofilm formation on inanimate substrate +namespace: biological_process +def: "A process whereby microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044399 ! multi-species biofilm formation + +[Term] +id: GO:0044401 +name: multi-species biofilm formation in or on host organism +namespace: biological_process +def: "A process whereby microorganisms of different species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044399 ! multi-species biofilm formation +is_a: GO:0044406 ! adhesion to host + +[Term] +id: GO:0044402 +name: competition with another organism +namespace: biological_process +def: "Any process by which an organism within a multispecies research community gains an advantage in growth or survival over another organism of a different species in that research community." [GOC:cc] +subset: gosubset_prok +synonym: "interspecies competition" BROAD [] +is_a: GO:0044419 ! interspecies interaction between organisms + +[Term] +id: GO:0044403 +name: symbiosis, encompassing mutualism through parasitism +namespace: biological_process +alt_id: GO:0043298 +alt_id: GO:0044404 +def: "An interaction between two organisms living together in more or less intimate association. The term host is usually used for the larger (macro) of the two members of a symbiosis. The smaller (micro) member is called the symbiont organism. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs." [GOC:cc, http://www.free-definition.com] +comment: Note that this term encompasses all symbiotic relationships between species along a continuum from mutualism through to parasitism, as outlined in the definition. +subset: goslim_generic +subset: gosubset_prok +synonym: "host-pathogen interaction" RELATED [] +synonym: "symbiosis" EXACT [] +synonym: "symbiotic interaction" EXACT [] +synonym: "symbiotic interaction between host and organism" RELATED [] +synonym: "symbiotic interaction between organisms" EXACT [] +synonym: "symbiotic interaction between species" EXACT [] +synonym: "symbiotic interaction with other non-host organism" RELATED [] +is_a: GO:0044419 ! interspecies interaction between organisms + +[Term] +id: GO:0044405 +name: recognition of host +namespace: biological_process +def: "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "detection of host" EXACT [] +is_a: GO:0051824 ! recognition of other organism during symbiotic interaction +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0044406 +name: adhesion to host +namespace: biological_process +def: "The attachment of an organism to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "host adhesion" EXACT [] +is_a: GO:0051701 ! interaction with host +is_a: GO:0051825 ! adhesion to other organism during symbiotic interaction + +[Term] +id: GO:0044407 +name: single-species biofilm formation in or on host organism +namespace: biological_process +def: "A process whereby microorganisms of the same species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044010 ! single-species biofilm formation +is_a: GO:0044406 ! adhesion to host + +[Term] +id: GO:0044408 +name: growth or development of symbiont on or near host +namespace: biological_process +def: "Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc] +subset: gosubset_prok +synonym: "growth or development of organism on or near host surface" EXACT [] +is_a: GO:0051827 ! growth or development on or near surface of other organism during symbiotic interaction +is_a: GO:0052108 ! growth or development of symbiont during interaction with host + +[Term] +id: GO:0044409 +name: entry into host +namespace: biological_process +def: "Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "host invasion" EXACT [] +synonym: "invasion into host" EXACT [] +synonym: "invasion of host" EXACT [] +synonym: "invasive growth" RELATED [] +is_a: GO:0051828 ! entry into other organism during symbiotic interaction +is_a: GO:0052126 ! movement in host environment + +[Term] +id: GO:0044410 +name: entry into host through natural portals +namespace: biological_process +def: "Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044409 ! entry into host +is_a: GO:0051829 ! entry into other organism through natural portals during symbiotic interaction + +[Term] +id: GO:0044411 +name: entry into host through host barriers +namespace: biological_process +def: "Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044409 ! entry into host +is_a: GO:0051830 ! entry into other organism through barriers of other organism during symbiotic interaction + +[Term] +id: GO:0044412 +name: growth or development of symbiont within host +namespace: biological_process +def: "The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "growth or development of organism within host" EXACT [] +synonym: "invasive growth" BROAD [] +is_a: GO:0051831 ! growth or development within other organism during symbiotic interaction +is_a: GO:0052108 ! growth or development of symbiont during interaction with host + +[Term] +id: GO:0044413 +name: avoidance of host defenses +namespace: biological_process +def: "Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "avoidance of host defences" EXACT [] +is_a: GO:0051701 ! interaction with host +is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction +is_a: GO:0052200 ! response to host defenses + +[Term] +id: GO:0044414 +name: suppression of host defenses +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "negative regulation of host defenses" EXACT [] +is_a: GO:0044413 ! avoidance of host defenses +is_a: GO:0051833 ! suppression of defenses of other organism during symbiotic interaction + +[Term] +id: GO:0044415 +name: evasion or tolerance of host defenses +namespace: biological_process +def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044413 ! avoidance of host defenses +is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction + +[Term] +id: GO:0044416 +name: induction by symbiont of host defense response +namespace: biological_process +def: "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "activation of host defense response" EXACT [] +is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0044417 +name: translocation of molecules into host +namespace: biological_process +def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051701 ! interaction with host +is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction + +[Term] +id: GO:0044418 +name: translocation of DNA into host +namespace: biological_process +def: "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +is_a: GO:0044417 ! translocation of molecules into host +is_a: GO:0051837 ! translocation of DNA into other organism during symbiotic interaction + +[Term] +id: GO:0044419 +name: interspecies interaction between organisms +namespace: biological_process +def: "Any process by which an organism has an effect on an organism of a different species." [GOC:cc] +subset: goslim_candida +subset: goslim_pir +subset: gosubset_prok +synonym: "interaction with another species" EXACT [] +synonym: "interspecies interaction" EXACT [] +synonym: "interspecies interaction with other organisms" EXACT [] +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0044420 +name: extracellular matrix part +namespace: cellular_component +def: "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0031012 ! extracellular matrix + +[Term] +id: GO:0044421 +name: extracellular region part +namespace: cellular_component +def: "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005575 ! cellular_component +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0044422 +name: organelle part +namespace: cellular_component +def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] +subset: gosubset_prok +is_a: GO:0005575 ! cellular_component +relationship: part_of GO:0043226 ! organelle + +[Term] +id: GO:0044423 +name: virion part +namespace: cellular_component +def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] +is_a: GO:0005575 ! cellular_component +relationship: part_of GO:0019012 ! virion + +[Term] +id: GO:0044424 +name: intracellular part +namespace: cellular_component +def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044464 ! cell part +relationship: part_of GO:0005622 ! intracellular + +[Term] +id: GO:0044425 +name: membrane part +namespace: cellular_component +def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044464 ! cell part +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0044426 +name: cell wall part +namespace: cellular_component +def: "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044462 ! external encapsulating structure part +relationship: part_of GO:0005618 ! cell wall + +[Term] +id: GO:0044427 +name: chromosomal part +namespace: cellular_component +def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl] +subset: gosubset_prok +synonym: "chromosomal component" EXACT [] +synonym: "chromosome component" EXACT [] +synonym: "chromosome part" EXACT [] +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0044428 +name: nuclear part +namespace: cellular_component +def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] +synonym: "nucleus component" EXACT [] +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0044429 +name: mitochondrial part +namespace: cellular_component +def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] +synonym: "mitochondrion component" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005739 ! mitochondrion + +[Term] +id: GO:0044430 +name: cytoskeletal part +namespace: cellular_component +def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] +synonym: "cytoskeleton component" EXACT [] +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0044431 +name: Golgi apparatus part +namespace: cellular_component +def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] +synonym: "Golgi component" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0044432 +name: endoplasmic reticulum part +namespace: cellular_component +def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] +synonym: "ER component" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0044433 +name: cytoplasmic vesicle part +namespace: cellular_component +def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0044434 +name: chloroplast part +namespace: cellular_component +def: "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl] +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0044435 +name: plastid part +namespace: cellular_component +def: "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0044436 +name: thylakoid part +namespace: cellular_component +def: "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0009579 ! thylakoid + +[Term] +id: GO:0044437 +name: vacuolar part +namespace: cellular_component +def: "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl] +subset: gosubset_prok +synonym: "vacuole component" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005773 ! vacuole + +[Term] +id: GO:0044438 +name: microbody part +namespace: cellular_component +def: "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0042579 ! microbody + +[Term] +id: GO:0044439 +name: peroxisomal part +namespace: cellular_component +def: "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl] +synonym: "peroxisome component" EXACT [] +is_a: GO:0044438 ! microbody part +relationship: part_of GO:0005777 ! peroxisome + +[Term] +id: GO:0044440 +name: endosomal part +namespace: cellular_component +def: "Any constituent part of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [GOC:jl] +synonym: "endosome component" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0044446 ! intracellular organelle part +relationship: part_of GO:0005768 ! endosome + +[Term] +id: GO:0044441 +name: cilium part +namespace: cellular_component +def: "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl] +is_a: GO:0044446 ! intracellular organelle part +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0044442 +name: microtubule-based flagellum part +namespace: cellular_component +def: "Any constituent part of a microtubule-based flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:jl, GOC:mtg_sensu] +synonym: "flagellar part (sensu Eukaryota)" EXACT [] +synonym: "flagellum part (sensu Eukaryota)" EXACT [] +is_a: GO:0044446 ! intracellular organelle part +is_a: GO:0044460 ! flagellum part +relationship: part_of GO:0009434 ! microtubule-based flagellum + +[Term] +id: GO:0044443 +name: fimbrial part +namespace: cellular_component +def: "Any constituent part of a fimbrium, a proteinaceous hair-like appendage on the surface of bacteria; range from 2-8 nm in diameter." [GOC:jl] +subset: gosubset_prok +synonym: "fimbrium component" EXACT [] +is_a: GO:0044446 ! intracellular organelle part +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0009289 ! fimbrium + +[Term] +id: GO:0044444 +name: cytoplasmic part +namespace: cellular_component +def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] +subset: gosubset_prok +synonym: "cytoplasm component" EXACT [] +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0044445 +name: cytosolic part +namespace: cellular_component +def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] +subset: gosubset_prok +synonym: "cytosol component" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0044446 +name: intracellular organelle part +namespace: cellular_component +def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044422 ! organelle part +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0043229 ! intracellular organelle + +[Term] +id: GO:0044447 +name: axoneme part +namespace: cellular_component +def: "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:jl] +is_a: GO:0044422 ! organelle part +is_a: GO:0044424 ! intracellular part +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0044448 +name: cell cortex part +namespace: cellular_component +def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl] +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0044449 +name: contractile fiber part +namespace: cellular_component +def: "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl] +synonym: "contractile fibre component" EXACT [] +synonym: "muscle fiber component" BROAD [] +synonym: "muscle fibre component" BROAD [] +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0043292 ! contractile fiber + +[Term] +id: GO:0044450 +name: microtubule organizing center part +namespace: cellular_component +def: "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl] +synonym: "microtubule organizing centre component" EXACT [] +synonym: "MTOC component" EXACT [] +is_a: GO:0044430 ! cytoskeletal part +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0044451 +name: nucleoplasm part +namespace: cellular_component +def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl] +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0044452 +name: nucleolar part +namespace: cellular_component +def: "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl] +synonym: "nucleolus component" EXACT [] +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0044453 +name: nuclear membrane part +namespace: cellular_component +def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl] +is_a: GO:0044425 ! membrane part +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0031965 ! nuclear membrane + +[Term] +id: GO:0044454 +name: nuclear chromosome part +namespace: cellular_component +def: "Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell." [GOC:jl] +is_a: GO:0044427 ! chromosomal part +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0044455 +name: mitochondrial membrane part +namespace: cellular_component +def: "Any constituent part of the mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl] +is_a: GO:0044425 ! membrane part +is_a: GO:0044429 ! mitochondrial part +relationship: part_of GO:0031966 ! mitochondrial membrane + +[Term] +id: GO:0044456 +name: synapse part +namespace: cellular_component +def: "Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl] +is_a: GO:0005575 ! cellular_component +relationship: part_of GO:0045202 ! synapse + +[Term] +id: GO:0044457 +name: cell septum part +namespace: cellular_component +def: "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl] +is_a: GO:0044464 ! cell part +relationship: part_of GO:0030428 ! cell septum + +[Term] +id: GO:0044459 +name: plasma membrane part +namespace: cellular_component +def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0044460 +name: flagellum part +namespace: cellular_component +def: "Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl] +subset: gosubset_prok +synonym: "flagellum component" EXACT [] +is_a: GO:0044463 ! cell projection part +relationship: part_of GO:0019861 ! flagellum + +[Term] +id: GO:0044461 +name: flagellin-based flagellum part +namespace: cellular_component +def: "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential." [GOC:jl, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "flagellar part (sensu Bacteria)" EXACT [] +synonym: "flagellum part (sensu Bacteria)" EXACT [] +is_a: GO:0044460 ! flagellum part +relationship: part_of GO:0009288 ! flagellin-based flagellum + +[Term] +id: GO:0044462 +name: external encapsulating structure part +namespace: cellular_component +def: "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044464 ! cell part +relationship: part_of GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0044463 +name: cell projection part +namespace: cellular_component +def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] +subset: gosubset_prok +is_a: GO:0044464 ! cell part +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0044464 +name: cell part +namespace: cellular_component +def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005575 ! cellular_component +relationship: part_of GO:0005623 ! cell + +[Term] +id: GO:0045002 +name: double-strand break repair via single-strand annealing +namespace: biological_process +def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529] +subset: gosubset_prok +is_a: GO:0000726 ! non-recombinational repair +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0045003 +name: double-strand break repair via synthesis-dependent strand annealing +namespace: biological_process +def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] +subset: gosubset_prok +synonym: "mitotic gene conversion" RELATED [] +synonym: "SDSA" BROAD [] +xref: Reactome:83667 +is_a: GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0045004 +name: DNA replication proofreading +namespace: biological_process +def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair +is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication + +[Term] +id: GO:0045005 +name: maintenance of fidelity during DNA-dependent DNA replication +namespace: biological_process +def: "The correction of errors made during DNA replication by either intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0045006 +name: DNA deamination +namespace: biological_process +def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0045007 +name: depurination +namespace: biological_process +def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai] +subset: gosubset_prok +xref: Reactome:212028 +xref: Reactome:221791 +xref: Reactome:230368 +xref: Reactome:238406 +xref: Reactome:244957 +xref: Reactome:252567 +xref: Reactome:255749 +xref: Reactome:259142 +xref: Reactome:262499 +xref: Reactome:265329 +xref: Reactome:268455 +xref: Reactome:274177 +xref: Reactome:280650 +xref: Reactome:282869 +xref: Reactome:286668 +xref: Reactome:288342 +xref: Reactome:291776 +xref: Reactome:292424 +xref: Reactome:293752 +xref: Reactome:73927 +is_a: GO:0006285 ! base-excision repair, AP site formation +is_a: GO:0006304 ! DNA modification +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process + +[Term] +id: GO:0045008 +name: depyrimidination +namespace: biological_process +def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai] +subset: gosubset_prok +xref: Reactome:212029 +xref: Reactome:221793 +xref: Reactome:230370 +xref: Reactome:238408 +xref: Reactome:244956 +xref: Reactome:249835 +xref: Reactome:252568 +xref: Reactome:255750 +xref: Reactome:259143 +xref: Reactome:262500 +xref: Reactome:265330 +xref: Reactome:268456 +xref: Reactome:274178 +xref: Reactome:280651 +xref: Reactome:282870 +xref: Reactome:286669 +xref: Reactome:288343 +xref: Reactome:289854 +xref: Reactome:290392 +xref: Reactome:291777 +xref: Reactome:292425 +xref: Reactome:293753 +xref: Reactome:73928 +is_a: GO:0006285 ! base-excision repair, AP site formation +is_a: GO:0006304 ! DNA modification +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process + +[Term] +id: GO:0045009 +name: chitosome +namespace: cellular_component +def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:8970154] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0045010 +name: actin nucleation +namespace: biological_process +def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] +synonym: "actin filament nucleation" EXACT [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0045011 +name: actin cable formation +namespace: biological_process +def: "The assembly of the long bundles of actin filaments known as actin cables." [PMID:11696322] +synonym: "actin cable assembly" EXACT [] +is_a: GO:0051017 ! actin filament bundle formation + +[Term] +id: GO:0045012 +name: MHC class II receptor activity +namespace: molecular_function +def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971] +comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'. +synonym: "class II major histocompatibility complex antigen" RELATED [] +synonym: "major histocompatibility complex class II receptor" EXACT [] +is_obsolete: true +consider: GO:0032395 +consider: GO:0042613 + +[Term] +id: GO:0045013 +name: negative regulation of transcription by carbon catabolites +namespace: biological_process +def: "Any process involving carbon catabolites that stops, prevents or reduces the rate of transcription. Carbon catabolite repression is a mechanism of genetic regulation in bacteria in which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11018147] +subset: gosubset_prok +synonym: "carbon catabolite repression" EXACT [] +synonym: "down regulation of transcription by carbon catabolites" EXACT [] +synonym: "down-regulation of transcription by carbon catabolites" EXACT [] +synonym: "downregulation of transcription by carbon catabolites" EXACT [] +synonym: "inhibition of transcription by carbon catabolites" NARROW [] +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +is_a: GO:0045990 ! regulation of transcription by carbon catabolites + +[Term] +id: GO:0045014 +name: negative regulation of transcription by glucose +namespace: biological_process +def: "Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11018147] +subset: gosubset_prok +synonym: "down regulation of transcription by glucose" EXACT [] +synonym: "down-regulation of transcription by glucose" EXACT [] +synonym: "downregulation of transcription by glucose" EXACT [] +synonym: "glucose effect" EXACT [] +synonym: "glucose repression" EXACT [] +synonym: "inhibition of transcription by glucose" NARROW [] +is_a: GO:0045013 ! negative regulation of transcription by carbon catabolites +is_a: GO:0046015 ! regulation of transcription by glucose + +[Term] +id: GO:0045015 +name: HDEL sequence binding +namespace: molecular_function +def: "Interacting selectively with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759] +synonym: "HDEL receptor activity" NARROW [] +is_a: GO:0046923 ! ER retention sequence binding + +[Term] +id: GO:0045016 +name: mitochondrial magnesium ion transport +namespace: biological_process +def: "The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein." [GOC:ai, PMID:11254124] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015693 ! magnesium ion transport + +[Term] +id: GO:0045017 +name: glycerolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] +subset: gosubset_prok +synonym: "glycerolipid anabolism" EXACT [] +synonym: "glycerolipid biosynthesis" EXACT [] +synonym: "glycerolipid formation" EXACT [] +synonym: "glycerolipid synthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0045018 +name: retrograde transport, vacuole to Golgi +namespace: biological_process +def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156] +synonym: "retrograde transport from the vacuole" EXACT [] +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0045019 +name: negative regulation of nitric oxide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] +synonym: "down regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "down-regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "downregulation of nitric oxide biosynthetic process" EXACT [] +synonym: "inhibition of nitric oxide biosynthetic process" NARROW [] +synonym: "negative regulation of nitric oxide anabolism" EXACT [] +synonym: "negative regulation of nitric oxide biosynthesis" EXACT [] +synonym: "negative regulation of nitric oxide formation" EXACT [] +synonym: "negative regulation of nitric oxide synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process + +[Term] +id: GO:0045020 +name: error-prone DNA repair +namespace: biological_process +def: "DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974] +subset: gosubset_prok +synonym: "mutagenic DNA repair" EXACT [] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0045021 +name: error-free DNA repair +namespace: biological_process +def: "DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0045022 +name: early endosome to late endosome transport +namespace: biological_process +def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194] +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0045023 +name: G0 to G1 transition +namespace: biological_process +def: "The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [ISBN:0716731363] +is_a: GO:0000320 ! re-entry into mitotic cell cycle + +[Term] +id: GO:0045024 +name: peptidyl-glutamyl peptide hydrolyzing enzyme activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0070011 + +[Term] +id: GO:0045025 +name: mitochondrial degradosome +namespace: cellular_component +def: "The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts." [PMID:10397341, PMID:9829834] +is_a: GO:0044429 ! mitochondrial part + +[Term] +id: GO:0045026 +name: plasma membrane fusion +namespace: biological_process +alt_id: GO:0006947 +def: "The joining of two or more lipid bilayer membranes that surround a cell." [GOC:elh, GOC:mtg_muscle] +synonym: "cell fusion" BROAD [] +synonym: "cell-cell fusion" BROAD [] +is_a: GO:0006944 ! membrane fusion + +[Term] +id: GO:0045027 +name: DNA end binding +namespace: molecular_function +def: "Interacting selectively with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0045028 +name: purinergic nucleotide receptor activity, G-protein coupled +namespace: molecular_function +def: "Combining with a purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] +synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT [] +synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT [] +synonym: "G-protein-coupled purinergic nucleotide receptor activity" EXACT [] +synonym: "P2Y" RELATED [] +synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT [] +is_a: GO:0001608 ! nucleotide receptor activity, G-protein coupled +is_a: GO:0001614 ! purinergic nucleotide receptor activity + +[Term] +id: GO:0045029 +name: UDP-activated nucleotide receptor activity +namespace: molecular_function +is_a: GO:0015065 ! uridine nucleotide receptor activity + +[Term] +id: GO:0045030 +name: UTP-activated nucleotide receptor activity +namespace: molecular_function +is_a: GO:0015065 ! uridine nucleotide receptor activity + +[Term] +id: GO:0045031 +name: ATP-activated nucleotide receptor activity +namespace: molecular_function +is_a: GO:0001609 ! adenosine receptor activity, G-protein coupled + +[Term] +id: GO:0045032 +name: ADP-activated nucleotide receptor activity +namespace: molecular_function +is_a: GO:0001609 ! adenosine receptor activity, G-protein coupled + +[Term] +id: GO:0045033 +name: peroxisome inheritance +namespace: biological_process +def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545] +is_a: GO:0007031 ! peroxisome organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0045034 +name: neuroblast division +namespace: biological_process +alt_id: GO:0043345 +alt_id: GO:0043346 +def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167] +comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division. +synonym: "neuroblast cell division" EXACT [] +synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT [] +synonym: "neuroblast division (sensu Vertebrata)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045035 +name: sensory organ precursor cell division +namespace: biological_process +def: "The series of 4 asymmetric divisions undergone by the sensory organ precursor cells to generate the four external sensory organ cells (the socket, shaft, sheath cells and the external sense neuron), together with one multidendritic neuron." [PMID:11171389] +synonym: "sense organ precursor cell division" EXACT [GOC:dph] +is_a: GO:0008356 ! asymmetric cell division +relationship: part_of GO:0007423 ! sensory organ development + +[Term] +id: GO:0045036 +name: protein targeting to chloroplast +namespace: biological_process +def: "The process of directing proteins towards the chloroplast using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363] +synonym: "protein-chloroplast targeting" EXACT [] +is_a: GO:0006605 ! protein targeting + +[Term] +id: GO:0045037 +name: protein import into chloroplast stroma +namespace: biological_process +def: "The import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363] +synonym: "chloroplast stroma protein import" EXACT [] +synonym: "protein transport into chloroplast stroma" EXACT [] +is_a: GO:0017038 ! protein import +is_a: GO:0045036 ! protein targeting to chloroplast + +[Term] +id: GO:0045038 +name: protein import into chloroplast thylakoid membrane +namespace: biological_process +def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363] +synonym: "chloroplast thylakoid membrane protein import" EXACT [] +synonym: "protein transport into chloroplast thylakoid membrane" EXACT [] +is_a: GO:0017038 ! protein import +is_a: GO:0045036 ! protein targeting to chloroplast + +[Term] +id: GO:0045039 +name: protein import into mitochondrial inner membrane +namespace: biological_process +def: "The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known." [ISBN:0716731363] +synonym: "mitochondrial inner membrane protein import" EXACT [] +synonym: "protein transport into mitochondrial inner membrane" EXACT [] +is_a: GO:0007007 ! inner mitochondrial membrane organization +is_a: GO:0043681 ! protein import into mitochondrion + +[Term] +id: GO:0045040 +name: protein import into mitochondrial outer membrane +namespace: biological_process +def: "The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane." [ISBN:0716731363] +synonym: "mitochondrial outer membrane protein import" EXACT [] +synonym: "protein transport into mitochondrial outer membrane" EXACT [] +is_a: GO:0007008 ! outer mitochondrial membrane organization +is_a: GO:0043681 ! protein import into mitochondrion + +[Term] +id: GO:0045041 +name: protein import into mitochondrial intermembrane space +namespace: biological_process +def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363] +synonym: "mitochondrial intermembrane space protein import" EXACT [] +synonym: "protein import into mitochondrial IMS" EXACT [] +synonym: "protein transport into mitochondrial IMS" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space" EXACT [] +is_a: GO:0043681 ! protein import into mitochondrion +is_a: GO:0065002 ! intracellular protein transmembrane transport + +[Term] +id: GO:0045042 +name: protein import into mitochondrial intermembrane space, conservative +namespace: biological_process +def: "The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363] +synonym: "conservative mitochondrial IMS protein import" EXACT [] +synonym: "conservative mitochondrial intermembrane space protein import" EXACT [] +synonym: "conservative protein transport into mitochondrial IMS" EXACT [] +synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT [] +synonym: "protein import into mitochondrial IMS, conservative" EXACT [] +synonym: "protein transport into mitochondrial IMS, conservative" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT [] +is_a: GO:0045041 ! protein import into mitochondrial intermembrane space + +[Term] +id: GO:0045043 +name: protein import into mitochondrial intermembrane space, nonconservative +namespace: biological_process +def: "The nonconservative import of proteins into the mitochondrial intermembrane space. The protein enters the intermembrane space and an uptake-targeting sequence functions as a stop-transfer sequence, blocking translocation of the C-terminus of the protein through the inner membrane. Cleavage of the uptake-targeting sequence by a protease in the intermembrane space releases the protein into the IMS." [ISBN:0716731363] +synonym: "non-conservative mitochondrial IMS protein import" EXACT [] +synonym: "non-conservative mitochondrial intermembrane space protein import" EXACT [] +synonym: "non-conservative protein transport into mitochondrial IMS" EXACT [] +synonym: "non-conservative protein transport into mitochondrial intermembrane space" EXACT [] +synonym: "nonconservative mitochondrial IMS protein import" EXACT [] +synonym: "nonconservative mitochondrial intermembrane space protein import" EXACT [] +synonym: "nonconservative protein transport into mitochondrial IMS" EXACT [] +synonym: "nonconservative protein transport into mitochondrial intermembrane space" EXACT [] +synonym: "protein import into mitochondrial IMS, non-conservative" EXACT [] +synonym: "protein import into mitochondrial IMS, nonconservative" EXACT [] +synonym: "protein import into mitochondrial intermembrane space, non-conservative" EXACT [] +synonym: "protein transport into mitochondrial IMS, non-conservative" EXACT [] +synonym: "protein transport into mitochondrial IMS, nonconservative" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space, non-conservative" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space, nonconservative" EXACT [] +is_a: GO:0045041 ! protein import into mitochondrial intermembrane space + +[Term] +id: GO:0045044 +name: protein import into mitochondrial intermembrane space, direct +namespace: biological_process +def: "Import of proteins directly into the mitochondrial intermembrane space without the assistance of any targeting signals. A conformational change ensures that the protein cannot diffuse back through the outer-membrane channels." [ISBN:0716731363] +synonym: "direct mitochondrial IMS protein import" EXACT [] +synonym: "direct mitochondrial intermembrane space protein import" EXACT [] +synonym: "direct protein transport into mitochondrial IMS" EXACT [] +synonym: "direct protein transport into mitochondrial intermembrane space" EXACT [] +synonym: "protein import into mitochondrial IMS, direct" EXACT [] +synonym: "protein transport into mitochondrial IMS, direct" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space, direct" EXACT [] +is_a: GO:0045041 ! protein import into mitochondrial intermembrane space + +[Term] +id: GO:0045045 +name: secretory pathway +namespace: biological_process +def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363] +comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations. +subset: goslim_pir +subset: gosubset_prok +is_obsolete: true +replaced_by: GO:0032940 + +[Term] +id: GO:0045046 +name: protein import into peroxisome membrane +namespace: biological_process +def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502] +synonym: "peroxisome membrane protein import" EXACT [] +synonym: "protein transport into peroxisome membrane" EXACT [] +is_a: GO:0006625 ! protein targeting to peroxisome +is_a: GO:0017038 ! protein import + +[Term] +id: GO:0045047 +name: protein targeting to ER +namespace: biological_process +def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363] +synonym: "protein targeting to endoplasmic reticulum" EXACT [] +synonym: "protein-endoplasmic reticulum targeting" EXACT [] +synonym: "protein-ER targeting" EXACT [] +is_a: GO:0006605 ! protein targeting + +[Term] +id: GO:0045048 +name: protein insertion into ER membrane +namespace: biological_process +def: "The process by which a protein is incorporated into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363] +synonym: "integral ER membrane protein localization" EXACT [] +synonym: "integral ER membrane protein positioning" EXACT [] +synonym: "localization of protein in ER membrane" EXACT [] +synonym: "positioning of protein in ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane" EXACT [] +synonym: "protein-endoplasmic reticulum insertion" EXACT [] +synonym: "protein-ER insertion" EXACT [] +is_a: GO:0051205 ! protein insertion into membrane +relationship: part_of GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0045049 +name: protein insertion into ER membrane by N-terminal cleaved signal sequence +namespace: biological_process +def: "The insertion of integral proteins into the endoplasmic reticulum membrane. N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363] +synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT [] +synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT [] +synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045050 +name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence +namespace: biological_process +def: "The insertion of integral proteins into the endoplasmic reticulum membrane. Stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363] +synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT [] +synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT [] +synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT [] +synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045051 +name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence +namespace: biological_process +def: "The insertion of integral proteins into the endoplasmic reticulum membrane. Signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363] +synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT [] +synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT [] +synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045052 +name: protein insertion into ER membrane by GPI attachment sequence +namespace: biological_process +def: "The insertion of integral proteins into the endoplasmic reticulum membrane. Proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363] +synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT [] +synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT [] +synonym: "protein-ER insertion by GPI attachment sequence" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045053 +name: protein retention in Golgi apparatus +namespace: biological_process +def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363] +synonym: "maintenance of protein location in Golgi apparatus" RELATED [] +synonym: "protein-Golgi retention" EXACT [] +synonym: "retention of protein in Golgi" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0034067 ! protein localization in Golgi apparatus + +[Term] +id: GO:0045054 +name: constitutive secretory pathway +namespace: biological_process +def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363] +is_a: GO:0006887 ! exocytosis + +[Term] +id: GO:0045055 +name: regulated secretory pathway +namespace: biological_process +def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363] +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0045056 +name: transcytosis +namespace: biological_process +def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0045057 +name: cisternal progression +namespace: biological_process +def: "The process by which a new cis-Golgi stack physically moves from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363] +synonym: "cisternal maturation" EXACT [] +is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport + +[Term] +id: GO:0045058 +name: T cell selection +namespace: biological_process +def: "The process by which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] +synonym: "T lymphocyte selection" EXACT [] +synonym: "T-cell selection" EXACT [] +synonym: "T-lymphocyte selection" EXACT [] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045059 +name: positive thymic T cell selection +namespace: biological_process +def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] +synonym: "positive thymic T lymphocyte selection" EXACT [] +synonym: "positive thymic T-cell selection" EXACT [] +synonym: "positive thymic T-lymphocyte selection" EXACT [] +is_a: GO:0043368 ! positive T cell selection +is_a: GO:0045061 ! thymic T cell selection + +[Term] +id: GO:0045060 +name: negative thymic T cell selection +namespace: biological_process +def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] +synonym: "negative thymic T lymphocyte selection" EXACT [] +synonym: "negative thymic T-cell selection" EXACT [] +synonym: "negative thymic T-lymphocyte selection" EXACT [] +is_a: GO:0043383 ! negative T cell selection +is_a: GO:0045061 ! thymic T cell selection + +[Term] +id: GO:0045061 +name: thymic T cell selection +namespace: biological_process +def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722] +synonym: "thymic T lymphocyte selection" EXACT [] +synonym: "thymic T-cell selection" EXACT [] +synonym: "thymic T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection +relationship: part_of GO:0033077 ! T cell differentiation in the thymus + +[Term] +id: GO:0045062 +name: extrathymic T cell selection +namespace: biological_process +def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383] +synonym: "extrathymic T lymphocyte selection" EXACT [] +synonym: "extrathymic T-cell selection" EXACT [] +synonym: "extrathymic T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection +relationship: part_of GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0045063 +name: T-helper 1 cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell." [GOC:ebc] +is_a: GO:0042093 ! T-helper cell differentiation +relationship: part_of GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0045064 +name: T-helper 2 cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell." [GOC:ebc] +is_a: GO:0042093 ! T-helper cell differentiation +relationship: part_of GO:0042092 ! T-helper 2 type immune response + +[Term] +id: GO:0045065 +name: cytotoxic T cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai] +synonym: "cytotoxic T lymphocyte selection" EXACT [] +synonym: "cytotoxic T-cell selection" EXACT [] +synonym: "cytotoxic T-lymphocyte selection" EXACT [] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045066 +name: regulatory T cell differentiation +namespace: biological_process +def: "The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulatory T lymphocyte differentiation" EXACT [] +synonym: "regulatory T-cell differentiation" EXACT [] +synonym: "regulatory T-lymphocyte differentiation" EXACT [] +synonym: "suppressor T cell differentiation" EXACT [] +synonym: "suppressor T lymphocyte differentiation" EXACT [] +synonym: "suppressor T-cell differentiation" EXACT [] +synonym: "suppressor T-lymphocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045067 +name: positive extrathymic T cell selection +namespace: biological_process +def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383] +synonym: "positive extrathymic T lymphocyte selection" EXACT [] +synonym: "positive extrathymic T-cell selection" EXACT [] +synonym: "positive extrathymic T-lymphocyte selection" EXACT [] +is_a: GO:0043368 ! positive T cell selection +is_a: GO:0045062 ! extrathymic T cell selection + +[Term] +id: GO:0045068 +name: negative extrathymic T cell selection +namespace: biological_process +def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383] +synonym: "negative extrathymic T lymphocyte selection" EXACT [] +synonym: "negative extrathymic T-cell selection" EXACT [] +synonym: "negative extrathymic T-lymphocyte selection" EXACT [] +is_a: GO:0043383 ! negative T cell selection +is_a: GO:0045062 ! extrathymic T cell selection + +[Term] +id: GO:0045069 +name: regulation of viral genome replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai] +is_a: GO:0050792 ! regulation of viral reproduction +relationship: regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0045070 +name: positive regulation of viral genome replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai] +synonym: "activation of viral genome replication" NARROW [] +synonym: "stimulation of viral genome replication" NARROW [] +synonym: "up regulation of viral genome replication" EXACT [] +synonym: "up-regulation of viral genome replication" EXACT [] +synonym: "upregulation of viral genome replication" EXACT [] +is_a: GO:0045069 ! regulation of viral genome replication +is_a: GO:0048524 ! positive regulation of viral reproduction +relationship: positively_regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0045071 +name: negative regulation of viral genome replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators] +synonym: "down regulation of viral genome replication" EXACT [] +synonym: "down-regulation of viral genome replication" EXACT [] +synonym: "downregulation of viral genome replication" EXACT [] +synonym: "inhibition of viral genome replication" NARROW [] +is_a: GO:0045069 ! regulation of viral genome replication +is_a: GO:0048525 ! negative regulation of viral reproduction +relationship: negatively_regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0045072 +name: regulation of interferon-gamma biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] +synonym: "regulation of interferon-gamma anabolism" EXACT [] +synonym: "regulation of interferon-gamma biosynthesis" EXACT [] +synonym: "regulation of interferon-gamma formation" EXACT [] +synonym: "regulation of interferon-gamma synthesis" EXACT [] +is_a: GO:0032649 ! regulation of interferon-gamma production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process + +[Term] +id: GO:0045073 +name: regulation of chemokine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] +synonym: "regulation of chemokine anabolism" EXACT [] +synonym: "regulation of chemokine biosynthesis" EXACT [] +synonym: "regulation of chemokine formation" EXACT [] +synonym: "regulation of chemokine synthesis" EXACT [] +is_a: GO:0032642 ! regulation of chemokine production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042033 ! chemokine biosynthetic process + +[Term] +id: GO:0045074 +name: regulation of interleukin-10 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] +synonym: "regulation of IL-10 biosynthesis" EXACT [] +synonym: "regulation of IL-10 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-10 anabolism" EXACT [] +synonym: "regulation of interleukin-10 biosynthesis" EXACT [] +synonym: "regulation of interleukin-10 formation" EXACT [] +synonym: "regulation of interleukin-10 synthesis" EXACT [] +is_a: GO:0032653 ! regulation of interleukin-10 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process + +[Term] +id: GO:0045075 +name: regulation of interleukin-12 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] +synonym: "regulation of IL-12 biosynthesis" EXACT [] +synonym: "regulation of IL-12 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-12 anabolism" EXACT [] +synonym: "regulation of interleukin-12 biosynthesis" EXACT [] +synonym: "regulation of interleukin-12 formation" EXACT [] +synonym: "regulation of interleukin-12 synthesis" EXACT [] +is_a: GO:0032655 ! regulation of interleukin-12 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process + +[Term] +id: GO:0045076 +name: regulation of interleukin-2 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] +synonym: "regulation of IL-2 biosynthesis" EXACT [] +synonym: "regulation of IL-2 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-2 anabolism" EXACT [] +synonym: "regulation of interleukin-2 biosynthesis" EXACT [] +synonym: "regulation of interleukin-2 formation" EXACT [] +synonym: "regulation of interleukin-2 synthesis" EXACT [] +is_a: GO:0032663 ! regulation of interleukin-2 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process + +[Term] +id: GO:0045077 +name: negative regulation of interferon-gamma biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] +synonym: "down regulation of interferon-gamma biosynthetic process" EXACT [] +synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT [] +synonym: "downregulation of interferon-gamma biosynthetic process" EXACT [] +synonym: "inhibition of interferon-gamma biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-gamma anabolism" EXACT [] +synonym: "negative regulation of interferon-gamma biosynthesis" EXACT [] +synonym: "negative regulation of interferon-gamma formation" EXACT [] +synonym: "negative regulation of interferon-gamma synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process +relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process + +[Term] +id: GO:0045078 +name: positive regulation of interferon-gamma biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators] +synonym: "activation of interferon-gamma biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-gamma anabolism" EXACT [] +synonym: "positive regulation of interferon-gamma biosynthesis" EXACT [] +synonym: "positive regulation of interferon-gamma formation" EXACT [] +synonym: "positive regulation of interferon-gamma synthesis" EXACT [] +synonym: "stimulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "up regulation of interferon-gamma biosynthetic process" EXACT [] +synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT [] +synonym: "upregulation of interferon-gamma biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process +relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process + +[Term] +id: GO:0045079 +name: negative regulation of chemokine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] +synonym: "down regulation of chemokine biosynthetic process" EXACT [] +synonym: "down-regulation of chemokine biosynthetic process" EXACT [] +synonym: "downregulation of chemokine biosynthetic process" EXACT [] +synonym: "inhibition of chemokine biosynthetic process" NARROW [] +synonym: "negative regulation of chemokine anabolism" EXACT [] +synonym: "negative regulation of chemokine biosynthesis" EXACT [] +synonym: "negative regulation of chemokine formation" EXACT [] +synonym: "negative regulation of chemokine synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045073 ! regulation of chemokine biosynthetic process +relationship: negatively_regulates GO:0042033 ! chemokine biosynthetic process + +[Term] +id: GO:0045080 +name: positive regulation of chemokine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators] +synonym: "activation of chemokine biosynthetic process" NARROW [] +synonym: "positive regulation of chemokine anabolism" EXACT [] +synonym: "positive regulation of chemokine biosynthesis" EXACT [] +synonym: "positive regulation of chemokine formation" EXACT [] +synonym: "positive regulation of chemokine synthesis" EXACT [] +synonym: "stimulation of chemokine biosynthetic process" NARROW [] +synonym: "up regulation of chemokine biosynthetic process" EXACT [] +synonym: "up-regulation of chemokine biosynthetic process" EXACT [] +synonym: "upregulation of chemokine biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045073 ! regulation of chemokine biosynthetic process +relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process + +[Term] +id: GO:0045081 +name: negative regulation of interleukin-10 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] +synonym: "down regulation of interleukin-10 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-10 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-10 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-10 biosynthesis" EXACT [] +synonym: "negative regulation of IL-10 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-10 anabolism" EXACT [] +synonym: "negative regulation of interleukin-10 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-10 formation" EXACT [] +synonym: "negative regulation of interleukin-10 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process +relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process + +[Term] +id: GO:0045082 +name: positive regulation of interleukin-10 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators] +synonym: "activation of interleukin-10 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-10 biosynthesis" EXACT [] +synonym: "positive regulation of IL-10 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-10 anabolism" EXACT [] +synonym: "positive regulation of interleukin-10 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-10 formation" EXACT [] +synonym: "positive regulation of interleukin-10 synthesis" EXACT [] +synonym: "stimulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-10 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-10 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process +relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process + +[Term] +id: GO:0045083 +name: negative regulation of interleukin-12 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] +synonym: "down regulation of interleukin-12 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-12 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-12 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-12 biosynthesis" EXACT [] +synonym: "negative regulation of IL-12 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-12 anabolism" EXACT [] +synonym: "negative regulation of interleukin-12 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-12 formation" EXACT [] +synonym: "negative regulation of interleukin-12 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process +relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process + +[Term] +id: GO:0045084 +name: positive regulation of interleukin-12 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators] +synonym: "activation of interleukin-12 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-12 biosynthesis" EXACT [] +synonym: "positive regulation of IL-12 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-12 anabolism" EXACT [] +synonym: "positive regulation of interleukin-12 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-12 formation" EXACT [] +synonym: "positive regulation of interleukin-12 synthesis" EXACT [] +synonym: "stimulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-12 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-12 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process +relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process + +[Term] +id: GO:0045085 +name: negative regulation of interleukin-2 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] +synonym: "down regulation of interleukin-2 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-2 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-2 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-2 biosynthesis" EXACT [] +synonym: "negative regulation of IL-2 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-2 anabolism" EXACT [] +synonym: "negative regulation of interleukin-2 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-2 formation" EXACT [] +synonym: "negative regulation of interleukin-2 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process +relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process + +[Term] +id: GO:0045086 +name: positive regulation of interleukin-2 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators] +synonym: "activation of interleukin-2 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-2 biosynthesis" EXACT [] +synonym: "positive regulation of IL-2 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-2 anabolism" EXACT [] +synonym: "positive regulation of interleukin-2 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-2 formation" EXACT [] +synonym: "positive regulation of interleukin-2 synthesis" EXACT [] +synonym: "stimulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-2 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-2 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process +relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process + +[Term] +id: GO:0045087 +name: innate immune response +namespace: biological_process +alt_id: GO:0002226 +def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu] +comment: This term was improved by GO_REF:0000022. It was moved. +synonym: "innate immune response (sensu Viridiplantae)" RELATED [] +synonym: "nonspecific immune response" EXACT [] +xref: Reactome:168249 +xref: Reactome:212097 +xref: Reactome:221856 +xref: Reactome:230427 +xref: Reactome:238466 +xref: Reactome:245026 +xref: Reactome:259214 +xref: Reactome:262571 +xref: Reactome:274227 +xref: Reactome:280696 +is_a: GO:0006952 ! defense response +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0045088 +name: regulation of innate immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0045087 ! innate immune response + +[Term] +id: GO:0045089 +name: positive regulation of innate immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] +synonym: "stimulation of innate immune response" NARROW [] +synonym: "up regulation of innate immune response" EXACT [] +synonym: "up-regulation of innate immune response" EXACT [] +synonym: "upregulation of innate immune response" EXACT [] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0045087 ! innate immune response + +[Term] +id: GO:0045090 +name: retroviral genome replication +namespace: biological_process +def: "Any process involved in the replication of a retroviral genome. Retroviruses use RNA as their nucleic acid and reverse transcriptase to copy their genome into the DNA of the host cells chromosomes." [GOC:go_curators, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0019079 ! viral genome replication + +[Term] +id: GO:0045091 +name: regulation of retroviral genome replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] +is_a: GO:0045069 ! regulation of viral genome replication +relationship: regulates GO:0045090 ! retroviral genome replication + +[Term] +id: GO:0045092 +name: interleukin-18 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0045093 +name: interleukin-18 alpha subunit binding +namespace: molecular_function +def: "Interacting selectively with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850, UniProtKB:Q14116] +synonym: "IL-18Ra binding" EXACT [] +is_a: GO:0042007 ! interleukin-18 binding + +[Term] +id: GO:0045094 +name: interleukin-18 beta subunit binding +namespace: molecular_function +def: "Interacting selectively with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850, UniProtKB:Q14116] +synonym: "IL-18Rb binding" EXACT [] +is_a: GO:0042007 ! interleukin-18 binding + +[Term] +id: GO:0045095 +name: keratin filament +namespace: cellular_component +def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363] +synonym: "acidic keratin" RELATED [] +synonym: "basic/neutral keratin" RELATED [] +is_a: GO:0005882 ! intermediate filament + +[Term] +id: GO:0045096 +name: acidic keratin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] +comment: This term was made obsolete because it represents a gene product. +synonym: "type I intermediate filament" EXACT [] +is_obsolete: true +replaced_by: GO:0045095 + +[Term] +id: GO:0045097 +name: basic/neutral keratin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] +comment: This term was made obsolete because it represents a gene product. +synonym: "type II intermediate filament" EXACT [] +is_obsolete: true +replaced_by: GO:0045095 + +[Term] +id: GO:0045098 +name: type III intermediate filament +namespace: cellular_component +def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363] +synonym: "desmin" NARROW [] +synonym: "glial fibrillary acidic protein" NARROW [] +synonym: "peripherin" NARROW [] +synonym: "type III intermediate filament associated protein" NARROW [] +synonym: "vimentin" NARROW [] +is_a: GO:0005882 ! intermediate filament + +[Term] +id: GO:0045099 +name: vimentin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0045098 + +[Term] +id: GO:0045100 +name: desmin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0045098 + +[Term] +id: GO:0045101 +name: glial fibrillary acidic protein +namespace: cellular_component +def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363] +comment: This term was made obsolete because it represents a gene product. +synonym: "GFAP" EXACT [] +is_obsolete: true +consider: GO:0045098 + +[Term] +id: GO:0045102 +name: peripherin +namespace: cellular_component +def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0045098 + +[Term] +id: GO:0045103 +name: intermediate filament-based process +namespace: biological_process +def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0045104 +name: intermediate filament cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] +synonym: "intermediate filament cytoskeleton organisation and biogenesis" EXACT [] +synonym: "intermediate filament cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0045103 ! intermediate filament-based process + +[Term] +id: GO:0045105 +name: intermediate filament polymerization or depolymerization +namespace: biological_process +def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai] +is_a: GO:0034621 ! cellular macromolecular complex subunit organization +is_a: GO:0045103 ! intermediate filament-based process + +[Term] +id: GO:0045106 +name: intermediate filament depolymerization +namespace: biological_process +def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363] +is_a: GO:0045105 ! intermediate filament polymerization or depolymerization +is_a: GO:0051261 ! protein depolymerization + +[Term] +id: GO:0045107 +name: intermediate filament polymerization +namespace: biological_process +def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884] +is_a: GO:0045105 ! intermediate filament polymerization or depolymerization +is_a: GO:0051258 ! protein polymerization + +[Term] +id: GO:0045108 +name: regulation of intermediate filament polymerization or depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363] +is_a: GO:0051246 ! regulation of protein metabolic process +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization + +[Term] +id: GO:0045109 +name: intermediate filament organization +namespace: biological_process +def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai] +synonym: "intermediate filament organisation" EXACT [] +is_a: GO:0045104 ! intermediate filament cytoskeleton organization + +[Term] +id: GO:0045110 +name: intermediate filament bundle assembly +namespace: biological_process +def: "The formation of the bundles of intermediate filaments, known as tonofilaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363] +synonym: "tonofilament assembly" NARROW [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0045109 ! intermediate filament organization + +[Term] +id: GO:0045111 +name: intermediate filament cytoskeleton +namespace: cellular_component +def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0045112 +name: integrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "integrin anabolism" EXACT [] +synonym: "integrin biosynthesis" EXACT [] +synonym: "integrin formation" EXACT [] +synonym: "integrin synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0045113 +name: regulation of integrin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] +synonym: "regulation of integrin anabolism" EXACT [] +synonym: "regulation of integrin biosynthesis" EXACT [] +synonym: "regulation of integrin formation" EXACT [] +synonym: "regulation of integrin synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045114 +name: beta 2 integrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators] +synonym: "beta 2 integrin anabolism" EXACT [] +synonym: "beta 2 integrin biosynthesis" EXACT [] +synonym: "beta 2 integrin formation" EXACT [] +synonym: "beta 2 integrin synthesis" EXACT [] +is_a: GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045115 +name: regulation of beta 2 integrin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] +synonym: "regulation of beta 2 integrin anabolism" EXACT [] +synonym: "regulation of beta 2 integrin biosynthesis" EXACT [] +synonym: "regulation of beta 2 integrin formation" EXACT [] +synonym: "regulation of beta 2 integrin synthesis" EXACT [] +is_a: GO:0045113 ! regulation of integrin biosynthetic process +relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process + +[Term] +id: GO:0045116 +name: protein neddylation +namespace: biological_process +alt_id: GO:0019943 +def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] +comment: Note that currently, the only known substrates of neddylation are cullin family proteins. +synonym: "RUB1-protein conjugation" EXACT [] +is_a: GO:0032446 ! protein modification by small protein conjugation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0045117 +name: azole transport +namespace: biological_process +def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0045118 +name: azole transporter activity +namespace: molecular_function +def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +is_a: GO:0015238 ! drug transporter activity + +[Term] +id: GO:0045119 +name: azole:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] +is_a: GO:0015307 ! drug:hydrogen antiporter activity + +[Term] +id: GO:0045120 +name: pronucleus +namespace: cellular_component +def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0045121 +name: membrane raft +namespace: cellular_component +def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198] +synonym: "GEM domain" RELATED [] +synonym: "glycolipid-enriched membrane domain" RELATED [] +synonym: "lipid raft" EXACT [] +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0045122 +name: aflatoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194] +subset: gosubset_prok +synonym: "aflatoxin anabolism" EXACT [] +synonym: "aflatoxin biosynthesis" EXACT [] +synonym: "aflatoxin formation" EXACT [] +synonym: "aflatoxin synthesis" EXACT [] +is_a: GO:0009805 ! coumarin biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0046222 ! aflatoxin metabolic process + +[Term] +id: GO:0045123 +name: cellular extravasation +namespace: biological_process +def: "The migration of leukocytes from the blood vessels into the surrounding tissue." [GOC:jl] +synonym: "immune cell cellular extravasation" EXACT [] +synonym: "leucocyte cellular extravasation" EXACT [] +synonym: "leukocyte cellular extravasation" EXACT [] +is_a: GO:0050900 ! leukocyte migration + +[Term] +id: GO:0045124 +name: regulation of bone resorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0046850 ! regulation of bone remodeling +relationship: regulates GO:0045453 ! bone resorption + +[Term] +id: GO:0045125 +name: bioactive lipid receptor activity +namespace: molecular_function +is_a: GO:0004930 ! G-protein coupled receptor activity + +[Term] +id: GO:0045127 +name: N-acetylglucosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate." [EC:2.7.1.59] +subset: gosubset_prok +synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" EXACT [EC:2.7.1.59] +synonym: "acetylaminodeoxyglucokinase activity" EXACT [EC:2.7.1.59] +synonym: "acetylglucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.59] +synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.59] +synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.59] +synonym: "GlcNAc kinase activity" EXACT [EC:2.7.1.59] +xref: EC:2.7.1.59 +xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0045128 +name: negative regulation of reciprocal meiotic recombination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of recombination during meiosis." [GOC:ai] +synonym: "down regulation of meiotic recombination" EXACT [] +synonym: "down-regulation of meiotic recombination" EXACT [] +synonym: "downregulation of meiotic recombination" EXACT [] +synonym: "inhibition of meiotic recombination" NARROW [] +synonym: "suppression of meiotic recombination" EXACT [] +is_a: GO:0010520 ! regulation of reciprocal meiotic recombination +is_a: GO:0045835 ! negative regulation of meiosis +is_a: GO:0045910 ! negative regulation of DNA recombination +relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0045129 +name: NAD-independent histone deacetylase activity +namespace: molecular_function +def: "Catalysis of the removal of one or more acetyl groups from a histone, independently of NAD." [GOC:ai, GOC:mah] +synonym: "AcuC" RELATED [] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0045130 +name: keratan sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21] +synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" EXACT [EC:2.8.2.21] +synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" EXACT [EC:2.8.2.21] +synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" EXACT [EC:2.8.2.21] +synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT [] +synonym: "keratan sulfate sulfotransferase activity" EXACT [EC:2.8.2.21] +synonym: "keratan sulphotransferase activity" EXACT [] +xref: EC:2.8.2.21 +xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0045131 +name: pre-mRNA branch point binding +namespace: molecular_function +def: "Interacting selectively with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0045132 +name: meiotic chromosome segregation +namespace: biological_process +def: "The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle." [GOC:ai] +is_a: GO:0007059 ! chromosome segregation +relationship: part_of GO:0007126 ! meiosis + +[Term] +id: GO:0045133 +name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoate oxygenase activity" EXACT [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoic oxygenase activity" EXACT [EC:1.13.11.14] +synonym: "o-pyrocatechuate oxygenase activity" EXACT [EC:1.13.11.14] +xref: EC:1.13.11.14 +xref: MetaCyc:1.13.11.14-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0045134 +name: uridine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6] +synonym: "UDPase activity" EXACT [EC:3.6.1.6] +synonym: "uridine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] +synonym: "uridine diphosphatase activity" EXACT [EC:3.6.1.6] +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0045135 +name: poly(beta-D-mannuronate) lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3] +subset: gosubset_prok +synonym: "alginase activity" EXACT [EC:4.2.2.3] +synonym: "alginase I" RELATED [EC:4.2.2.3] +synonym: "alginate lyase activity" EXACT [EC:4.2.2.3] +synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3] +synonym: "poly(beta-D-1,4-mannuronide) lyase activity" EXACT [EC:4.2.2.3] +synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3] +xref: EC:4.2.2.3 +xref: MetaCyc:4.2.2.3-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0045136 +name: development of secondary sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai] +is_a: GO:0003006 ! reproductive developmental process +relationship: part_of GO:0007275 ! multicellular organismal development +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0045137 +name: development of primary sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] +is_a: GO:0003006 ! reproductive developmental process +relationship: part_of GO:0007275 ! multicellular organismal development +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0045138 +name: tail tip morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the tail tip are generated and organized. Morphogenesis pertains to the creation of form. The tail tip undergoes morphogenesis to form a copulatory structure. The most posterior hypodermal cells in the tail define a specialized, sexually dimorphic compartment in which cells fuse and retract in the male, changing their shape from a tapered cone to a blunt dome." [PMID:10049567] +synonym: "male tail morphogenesis (sensu Nematoda)" EXACT [] +synonym: "tail tip morphogenesis (sensu Nematoda)" EXACT [] +is_a: GO:0035121 ! tail morphogenesis + +[Term] +id: GO:0045139 +name: copper sensitivity/resistance +namespace: biological_process +def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +is_obsolete: true +replaced_by: GO:0046688 + +[Term] +id: GO:0045140 +name: inositol phosphoceramide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099] +synonym: "IPC synthase activity" EXACT [] +xref: EC:2.4.1.- +xref: MetaCyc:RXN3O-581 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0045141 +name: meiotic telomere clustering +namespace: biological_process +def: "The cell cycle process whereby the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis." [GOC:vw, PMID:10690419] +synonym: "bouquet biosynthesis" NARROW [] +synonym: "bouquet formation" NARROW [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0034397 ! telomere localization +relationship: part_of GO:0007126 ! meiosis + +[Term] +id: GO:0045142 +name: triplex DNA binding +namespace: molecular_function +def: "Interacting selectively with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538] +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0045143 +name: homologous chromosome segregation +namespace: biological_process +alt_id: GO:0007061 +def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] +synonym: "meiosis I, chromosome segregation" EXACT [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0045144 +name: meiotic sister chromatid segregation +namespace: biological_process +def: "The cell cycle process whereby sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] +synonym: "meiosis II, chromosome segregation" EXACT [] +is_a: GO:0000819 ! sister chromatid segregation +relationship: part_of GO:0007135 ! meiosis II +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0045145 +name: single-stranded DNA specific 5'-3' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai] +is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity +is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity + +[Term] +id: GO:0045146 +name: initiation of acetate catabolic process by acetate +namespace: biological_process +def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859] +subset: gosubset_prok +synonym: "initiation of acetate breakdown by acetate" EXACT [] +synonym: "initiation of acetate degradation by acetate" EXACT [] +is_a: GO:0010034 ! response to acetate +is_a: GO:0043077 ! initiation of acetate catabolic process + +[Term] +id: GO:0045147 +name: regulation of initiation of acetate catabolic process by acetate +namespace: biological_process +def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of initiation of acetate breakdown by acetate" EXACT [] +synonym: "regulation of initiation of acetate degradation by acetate" EXACT [] +is_a: GO:0045734 ! regulation of acetate catabolic process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate + +[Term] +id: GO:0045148 +name: tripeptide aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the release of the N-terminal residue from a tripeptide." [EC:3.4.11.4] +subset: gosubset_prok +synonym: "alanine-phenylalanine-proline arylamidase activity" EXACT [EC:3.4.11.4] +synonym: "aminoexotripeptidase activity" EXACT [EC:3.4.11.4] +synonym: "aminotripeptidase activity" EXACT [] +synonym: "imidoendopeptidase activity" EXACT [EC:3.4.11.4] +synonym: "lymphopeptidase activity" EXACT [EC:3.4.11.4] +synonym: "peptidase B" RELATED [EC:3.4.11.4] +synonym: "peptidase T" EXACT [] +xref: EC:3.4.11.4 +xref: MetaCyc:3.4.11.4-RXN +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0034701 ! tripeptidase activity + +[Term] +id: GO:0045149 +name: acetoin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg] +subset: gosubset_prok +synonym: "acetoin metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0045150 +name: acetoin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] +subset: gosubset_prok +synonym: "acetoin breakdown" EXACT [] +synonym: "acetoin catabolism" EXACT [] +synonym: "acetoin degradation" EXACT [] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0045149 ! acetoin metabolic process + +[Term] +id: GO:0045151 +name: acetoin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] +subset: gosubset_prok +synonym: "acetoin anabolism" EXACT [] +synonym: "acetoin biosynthesis" EXACT [] +synonym: "acetoin formation" EXACT [] +synonym: "acetoin synthesis" EXACT [] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0045149 ! acetoin metabolic process + +[Term] +id: GO:0045152 +name: antisigma factor binding +namespace: molecular_function +def: "Interacting selectively with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg] +subset: gosubset_prok +synonym: "antisigma factor antagonist activity" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045153 +name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363] +synonym: "cytochrome" RELATED [] +synonym: "cytochrome b562" NARROW [] +synonym: "cytochrome b566" NARROW [] +synonym: "cytochrome c1" NARROW [] +synonym: "soluble cytochrome b562" RELATED [] +xref: Reactome:19911 +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0045154 +name: electron transporter, transferring electrons within cytochrome c oxidase complex activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] +synonym: "cytochrome" RELATED [] +synonym: "cytochrome a" NARROW [] +synonym: "cytochrome a3/copper complex" NARROW [] +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0045155 +name: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity +namespace: molecular_function +def: "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] +subset: gosubset_prok +synonym: "cytochrome" RELATED [] +synonym: "cytochrome c" NARROW [] +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0045156 +name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] +subset: gosubset_prok +synonym: "cytochrome" RELATED [] +synonym: "cytochrome bc1 complex" NARROW [] +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0045157 +name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] +synonym: "cytochrome" RELATED [] +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0045158 +name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] +subset: gosubset_prok +synonym: "cytochrome" RELATED [] +synonym: "cytochrome b/b6" RELATED [] +synonym: "cytochrome b6" NARROW [] +synonym: "cytochrome f" NARROW [] +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0045159 +name: myosin II binding +namespace: molecular_function +def: "Interacting selectively with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0045160 +name: myosin I complex +namespace: cellular_component +def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0045161 +name: neuronal ion channel clustering +namespace: biological_process +def: "The process by which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0042551 ! neuron maturation + +[Term] +id: GO:0045162 +name: clustering of voltage-gated sodium channels +namespace: biological_process +def: "The process by which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440] +synonym: "clustering of voltage gated sodium channels" EXACT [] +synonym: "clustering of voltage-dependent sodium channels" EXACT [] +synonym: "Nav channel clustering" EXACT [] +synonym: "voltage-gated sodium channel clustering" EXACT [] +is_a: GO:0045161 ! neuronal ion channel clustering + +[Term] +id: GO:0045163 +name: clustering of voltage-gated potassium channels +namespace: biological_process +def: "The process by which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440] +synonym: "clustering of voltage gated potassium channels" EXACT [] +synonym: "clustering of voltage-dependent potassium channels" EXACT [] +synonym: "Kv channel clustering" EXACT [] +synonym: "voltage-gated potassium channel clustering" EXACT [] +is_a: GO:0045161 ! neuronal ion channel clustering + +[Term] +id: GO:0045164 +name: secretin (sensu Mammalia) +namespace: molecular_function +def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551] +comment: This term was made obsolete because it represents a gene product rather than a molecular function. +is_obsolete: true +consider: GO:0046659 + +[Term] +id: GO:0045165 +name: cell fate commitment +namespace: biological_process +def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] +comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0030154 ! cell differentiation + +[Term] +id: GO:0045167 +name: asymmetric protein localization during cell fate commitment +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] +synonym: "asymmetric protein localization involved in cell fate commitment" EXACT [] +synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT [] +synonym: "cell fate commitment, asymmetric protein localization" EXACT [] +is_a: GO:0008105 ! asymmetric protein localization +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0045168 +name: cell-cell signaling involved in cell fate commitment +namespace: biological_process +def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "cell fate commitment, cell-cell signaling" EXACT [] +synonym: "cell fate commitment, cell-cell signalling" EXACT [] +synonym: "cell-cell signaling involved in cell fate commitment" EXACT [] +synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] +synonym: "cell-cell signalling during cell fate commitment" EXACT [] +synonym: "cell-cell signalling involved in cell fate commitment" EXACT [] +synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0045169 +name: fusome +namespace: cellular_component +def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045170 +name: spectrosome +namespace: cellular_component +def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045171 +name: intercellular bridge +namespace: cellular_component +def: "A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells." [PMID:9635420] +is_a: GO:0044421 ! extracellular region part + +[Term] +id: GO:0045172 +name: germline ring canal +namespace: cellular_component +def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] +synonym: "ring canal (sensu Insecta)" EXACT [] +is_a: GO:0045171 ! intercellular bridge + +[Term] +id: GO:0045173 +name: O-sialoglycoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "O-sialoglycoprotein breakdown" EXACT [] +synonym: "O-sialoglycoprotein catabolism" EXACT [] +synonym: "O-sialoglycoprotein degradation" EXACT [] +is_a: GO:0006516 ! glycoprotein catabolic process + +[Term] +id: GO:0045174 +name: glutathione dehydrogenase (ascorbate) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate." [EC:1.8.5.1] +synonym: "dehydroascorbate reductase activity" EXACT [] +synonym: "dehydroascorbic acid reductase activity" EXACT [EC:1.8.5.1] +synonym: "dehydroascorbic reductase activity" EXACT [EC:1.8.5.1] +synonym: "DHA reductase activity" EXACT [EC:1.8.5.1] +synonym: "GDOR" RELATED [EC:1.8.5.1] +synonym: "glutathione dehydroascorbate reductase activity" EXACT [EC:1.8.5.1] +synonym: "glutathione:dehydroascorbate oxidoreductase activity" EXACT [EC:1.8.5.1] +synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.8.5.1] +xref: EC:1.8.5.1 +xref: MetaCyc:1.8.5.1-RXN +is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016672 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0045175 +name: basal protein localization +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] +synonym: "establishment and maintenance of basal protein localization" EXACT [] +synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT [] +is_a: GO:0008105 ! asymmetric protein localization + +[Term] +id: GO:0045176 +name: apical protein localization +namespace: biological_process +def: "Any process by which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] +synonym: "establishment and maintenance of apical protein localization" EXACT [] +synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT [] +is_a: GO:0008105 ! asymmetric protein localization + +[Term] +id: GO:0045177 +name: apical part of cell +namespace: cellular_component +def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] +subset: goslim_pir +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0045178 +name: basal part of cell +namespace: cellular_component +def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:bmah, ISBN:0185316194] +subset: goslim_pir +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0045179 +name: apical cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0045180 +name: basal cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf] +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0045178 ! basal part of cell + +[Term] +id: GO:0045181 +name: glutamate synthase activity, NADH or NADPH as acceptor +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14] +subset: gosubset_prok +xref: EC:1.4.1.- +is_a: GO:0015930 ! glutamate synthase activity +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045182 +name: translation regulator activity +namespace: molecular_function +def: "Any substance involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] +subset: goslim_candida +subset: goslim_generic +subset: goslim_goa +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +subset: gosubset_prok +synonym: "translation factor activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0045183 +name: translation factor activity, non-nucleic acid binding +namespace: molecular_function +def: "Any of a group of soluble proteins involved in polypeptide synthesis at the ribosome which do not bind to nucleic acids." [GOC:ai] +subset: gosubset_prok +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0045184 +name: establishment of protein localization +namespace: biological_process +def: "The directed movement of a protein to a specific location." [GOC:bf] +subset: gosubset_prok +synonym: "protein positioning" EXACT [] +synonym: "protein recruitment" EXACT [] +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0008104 ! protein localization + +[Term] +id: GO:0045185 +name: maintenance of protein location +namespace: biological_process +def: "Any process by which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] +subset: gosubset_prok +synonym: "active protein retrieval" NARROW [] +synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] +synonym: "protein retention" NARROW [] +synonym: "protein sequestering" NARROW [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0008104 ! protein localization + +[Term] +id: GO:0045186 +name: zonula adherens assembly +namespace: biological_process +def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] +is_a: GO:0007043 ! cell-cell junction assembly +relationship: part_of GO:0043297 ! apical junction assembly + +[Term] +id: GO:0045187 +name: regulation of circadian sleep/wake cycle, sleep +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] +synonym: "regulation of sleep" EXACT [] +is_a: GO:0042749 ! regulation of circadian sleep/wake cycle +relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0045188 +name: regulation of circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators] +synonym: "regulation of non-REM sleep" EXACT [] +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep + +[Term] +id: GO:0045189 +name: connective tissue growth factor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de] +synonym: "connective tissue growth factor anabolism" EXACT [] +synonym: "connective tissue growth factor biosynthesis" EXACT [] +synonym: "connective tissue growth factor formation" EXACT [] +synonym: "connective tissue growth factor synthesis" EXACT [] +synonym: "CTGF biosynthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0045190 +name: isotype switching +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [http://cancerweb.ncl.ac.uk/, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to GO:0045191. +synonym: "class switch recombination" EXACT [] +synonym: "class switching" EXACT [] +synonym: "isotype switch recombination" EXACT [] +is_a: GO:0002204 ! somatic recombination of immunoglobulin genes during immune response +is_a: GO:0042113 ! B cell activation + +[Term] +id: GO:0045191 +name: regulation of isotype switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai] +synonym: "regulation of class switch recombination" EXACT [] +synonym: "regulation of class switching" EXACT [] +synonym: "regulation of isotype switch recombination" EXACT [] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050864 ! regulation of B cell activation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0045190 ! isotype switching + +[Term] +id: GO:0045192 +name: low-density lipoprotein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. +synonym: "LDL catabolic process" EXACT [] +synonym: "LDL catabolism" EXACT [] +synonym: "low-density lipoprotein breakdown" EXACT [] +synonym: "low-density lipoprotein catabolism" EXACT [] +synonym: "low-density lipoprotein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045193 +name: acetylated low-density lipoprotein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators] +comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. +synonym: "Ac-LDL catabolic process" EXACT [] +synonym: "Ac-LDL catabolism" EXACT [] +synonym: "acetylated low-density lipoprotein breakdown" EXACT [] +synonym: "acetylated low-density lipoprotein catabolism" EXACT [] +synonym: "acetylated low-density lipoprotein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045194 +name: oxidized low-density lipoprotein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators] +comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. +synonym: "Ox-LDL catabolic process" EXACT [] +synonym: "Ox-LDL catabolism" EXACT [] +synonym: "oxidized low-density lipoprotein breakdown" EXACT [] +synonym: "oxidized low-density lipoprotein catabolism" EXACT [] +synonym: "oxidized low-density lipoprotein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045195 +name: gallstone formation +namespace: biological_process +def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm] +comment: This term was made obsolete because the process it represents is pathological. +is_obsolete: true + +[Term] +id: GO:0045196 +name: establishment or maintenance of neuroblast polarity +namespace: biological_process +alt_id: GO:0043339 +alt_id: GO:0043342 +def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu] +synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] +synonym: "establishment and/or maintenance of neuroblast polarity (sensu Nematoda and Protostomia)" EXACT [] +synonym: "establishment and/or maintenance of neuroblast polarity (sensu Vertebrata)" EXACT [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0045197 +name: establishment or maintenance of epithelial cell apical/basal polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] +is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity + +[Term] +id: GO:0045198 +name: establishment of epithelial cell apical/basal polarity +namespace: biological_process +def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:bf] +is_a: GO:0030859 ! polarized epithelial cell differentiation +is_a: GO:0035089 ! establishment of apical/basal cell polarity +is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity + +[Term] +id: GO:0045199 +name: maintenance of epithelial cell apical/basal polarity +namespace: biological_process +def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf] +is_a: GO:0035090 ! maintenance of apical/basal cell polarity +is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity + +[Term] +id: GO:0045200 +name: establishment of neuroblast polarity +namespace: biological_process +alt_id: GO:0043340 +alt_id: GO:0043343 +def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] +synonym: "establishment of neuroblast cell polarity" EXACT [] +synonym: "establishment of neuroblast polarity (sensu Nematoda and Protostomia)" EXACT [] +synonym: "establishment of neuroblast polarity (sensu Vertebrata)" EXACT [] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity + +[Term] +id: GO:0045201 +name: maintenance of neuroblast polarity +namespace: biological_process +alt_id: GO:0043341 +alt_id: GO:0043344 +def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] +synonym: "maintenance of neuroblast cell polarity" EXACT [] +synonym: "maintenance of neuroblast polarity (sensu Nematoda and Protostomia)" EXACT [] +synonym: "maintenance of neuroblast polarity (sensu Vertebrata)" EXACT [] +is_a: GO:0030011 ! maintenance of cell polarity +is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity + +[Term] +id: GO:0045202 +name: synapse +namespace: cellular_component +def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +synonym: "synaptic junction" EXACT [] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0045203 +name: integral to cell outer membrane +namespace: cellular_component +def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the external outer membrane of the cell. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "integral to external membrane (sensu Gram-negative Bacteria)" EXACT [] +synonym: "integral to external membrane (sensu Proteobacteria)" EXACT [] +synonym: "integral to outer membrane (sensu Gram-negative Bacteria)" EXACT [] +synonym: "integral to outer membrane (sensu Proteobacteria)" EXACT [] +is_a: GO:0016021 ! integral to membrane +is_a: GO:0031230 ! intrinsic to cell outer membrane + +[Term] +id: GO:0045204 +name: MAPK export from nucleus +namespace: biological_process +def: "The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc] +synonym: "cytoplasmic translocation of MAP kinase" EXACT [] +synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT [] +synonym: "MAPK export from cell nucleus" EXACT [] +synonym: "MAPK export out of nucleus" EXACT [] +synonym: "MAPK transport from nucleus to cytoplasm" EXACT [] +synonym: "MAPK-nucleus export" EXACT [] +is_a: GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0045205 +name: MAPK transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of, within or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because we do not know what it was intended to represent when it was created. +is_obsolete: true + +[Term] +id: GO:0045206 +name: MAPK phosphatase transporter activity +namespace: molecular_function +alt_id: GO:0045207 +def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of, within or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because we do not know what it was intended to represent when it was created. +synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW [] +synonym: "leptomycin B-sensitive MKP shuttle" NARROW [] +synonym: "MKP shuttle" NARROW [] +is_obsolete: true + +[Term] +id: GO:0045208 +name: MAPK phosphatase export from nucleus +namespace: biological_process +def: "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] +synonym: "MAPK phosphatase export from cell nucleus" EXACT [] +synonym: "MAPK phosphatase export out of nucleus" EXACT [] +synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] +synonym: "MAPK phosphatase-nucleus export" EXACT [] +is_a: GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0045209 +name: MAPK phosphatase export from nucleus, leptomycin B sensitive +namespace: biological_process +def: "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] +synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT [] +synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] +synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT [] +synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT [] +synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT [] +synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT [] +synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT [] +is_a: GO:0045208 ! MAPK phosphatase export from nucleus + +[Term] +id: GO:0045210 +name: FasL biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of FasL (CD95), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/] +synonym: "Apo-1 biosynthesis" EXACT [] +synonym: "Apo-1 biosynthetic process" EXACT [] +synonym: "CD95 biosynthesis" EXACT [] +synonym: "CD95 biosynthetic process" EXACT [] +synonym: "FasL anabolism" EXACT [] +synonym: "FasL biosynthesis" EXACT [] +synonym: "FasL formation" EXACT [] +synonym: "FasL synthesis" EXACT [] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0045211 +name: postsynaptic membrane +namespace: cellular_component +def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0016020 ! membrane +is_a: GO:0044456 ! synapse part + +[Term] +id: GO:0045212 +name: neurotransmitter receptor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai] +synonym: "neurotransmitter receptor anabolism" EXACT [] +synonym: "neurotransmitter receptor biosynthesis" EXACT [] +synonym: "neurotransmitter receptor formation" EXACT [] +synonym: "neurotransmitter receptor synthesis" EXACT [] +is_a: GO:0032800 ! receptor biosynthetic process +is_a: GO:0045213 ! neurotransmitter receptor metabolic process + +[Term] +id: GO:0045213 +name: neurotransmitter receptor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators] +synonym: "neurotransmitter receptor metabolism" EXACT [] +is_a: GO:0043112 ! receptor metabolic process +relationship: part_of GO:0007268 ! synaptic transmission + +[Term] +id: GO:0045214 +name: sarcomere organization +namespace: biological_process +alt_id: GO:0006938 +def: "The myofibril assembly process by which the muscle actomyosin is organized into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] +synonym: "sarcomere alignment" EXACT [] +synonym: "sarcomere organisation" EXACT [] +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0045216 +name: cell-cell junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "cell-cell junction assembly and maintenance" EXACT [] +synonym: "cell-cell junction biogenesis" RELATED [] +synonym: "intercellular junction assembly and maintenance" EXACT [] +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0045217 +name: cell-cell junction maintenance +namespace: biological_process +def: "The maintenance of junctions between cells." [GOC:ai] +synonym: "intercellular junction maintenance" EXACT [] +is_a: GO:0034331 ! cell junction maintenance +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0045218 +name: zonula adherens maintenance +namespace: biological_process +def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf] +is_a: GO:0045217 ! cell-cell junction maintenance + +[Term] +id: GO:0045219 +name: regulation of FasL biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] +synonym: "regulation of FasL anabolism" EXACT [] +synonym: "regulation of FasL biosynthesis" EXACT [] +synonym: "regulation of FasL formation" EXACT [] +synonym: "regulation of FasL synthesis" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0045210 ! FasL biosynthetic process + +[Term] +id: GO:0045220 +name: positive regulation of FasL biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] +synonym: "activation of FasL biosynthetic process" NARROW [] +synonym: "positive regulation of FasL anabolism" EXACT [] +synonym: "positive regulation of FasL biosynthesis" EXACT [] +synonym: "positive regulation of FasL formation" EXACT [] +synonym: "positive regulation of FasL synthesis" EXACT [] +synonym: "stimulation of FasL biosynthetic process" NARROW [] +synonym: "up regulation of FasL biosynthetic process" EXACT [] +synonym: "up-regulation of FasL biosynthetic process" EXACT [] +synonym: "upregulation of FasL biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0045219 ! regulation of FasL biosynthetic process +relationship: positively_regulates GO:0045210 ! FasL biosynthetic process + +[Term] +id: GO:0045221 +name: negative regulation of FasL biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] +synonym: "down regulation of FasL biosynthetic process" EXACT [] +synonym: "down-regulation of FasL biosynthetic process" EXACT [] +synonym: "downregulation of FasL biosynthetic process" EXACT [] +synonym: "inhibition of FasL biosynthetic process" NARROW [] +synonym: "negative regulation of FasL anabolism" EXACT [] +synonym: "negative regulation of FasL biosynthesis" EXACT [] +synonym: "negative regulation of FasL formation" EXACT [] +synonym: "negative regulation of FasL synthesis" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0045219 ! regulation of FasL biosynthetic process +relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process + +[Term] +id: GO:0045222 +name: CD4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "CD4 anabolism" EXACT [] +synonym: "CD4 biosynthesis" EXACT [] +synonym: "CD4 formation" EXACT [] +synonym: "CD4 synthesis" EXACT [] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0045223 +name: regulation of CD4 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] +synonym: "regulation of CD4 anabolism" EXACT [] +synonym: "regulation of CD4 biosynthesis" EXACT [] +synonym: "regulation of CD4 formation" EXACT [] +synonym: "regulation of CD4 synthesis" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0045222 ! CD4 biosynthetic process + +[Term] +id: GO:0045224 +name: positive regulation of CD4 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] +synonym: "activation of CD4 biosynthetic process" NARROW [] +synonym: "positive regulation of CD4 anabolism" EXACT [] +synonym: "positive regulation of CD4 biosynthesis" EXACT [] +synonym: "positive regulation of CD4 formation" EXACT [] +synonym: "positive regulation of CD4 synthesis" EXACT [] +synonym: "stimulation of CD4 biosynthetic process" NARROW [] +synonym: "up regulation of CD4 biosynthetic process" EXACT [] +synonym: "up-regulation of CD4 biosynthetic process" EXACT [] +synonym: "upregulation of CD4 biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0045223 ! regulation of CD4 biosynthetic process +relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process + +[Term] +id: GO:0045225 +name: negative regulation of CD4 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] +synonym: "down regulation of CD4 biosynthetic process" EXACT [] +synonym: "down-regulation of CD4 biosynthetic process" EXACT [] +synonym: "downregulation of CD4 biosynthetic process" EXACT [] +synonym: "inhibition of CD4 biosynthetic process" NARROW [] +synonym: "negative regulation of CD4 anabolism" EXACT [] +synonym: "negative regulation of CD4 biosynthesis" EXACT [] +synonym: "negative regulation of CD4 formation" EXACT [] +synonym: "negative regulation of CD4 synthesis" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0045223 ! regulation of CD4 biosynthetic process +relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process + +[Term] +id: GO:0045226 +name: extracellular polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] +subset: gosubset_prok +synonym: "extracellular polysaccharide anabolism" EXACT [] +synonym: "extracellular polysaccharide biosynthesis" EXACT [] +synonym: "extracellular polysaccharide formation" EXACT [] +synonym: "extracellular polysaccharide synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046379 ! extracellular polysaccharide metabolic process + +[Term] +id: GO:0045227 +name: capsule polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "capsular polysaccharide biosynthesis" EXACT [] +synonym: "capsular polysaccharide biosynthetic process" EXACT [] +synonym: "capsule polysaccharide anabolism" EXACT [] +synonym: "capsule polysaccharide biosynthesis" EXACT [] +synonym: "capsule polysaccharide formation" EXACT [] +synonym: "capsule polysaccharide synthesis" EXACT [] +is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process +is_a: GO:0045230 ! capsule organization + +[Term] +id: GO:0045228 +name: slime layer polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "slime layer polysaccharide anabolism" EXACT [] +synonym: "slime layer polysaccharide biosynthesis" EXACT [] +synonym: "slime layer polysaccharide formation" EXACT [] +synonym: "slime layer polysaccharide synthesis" EXACT [] +is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process +is_a: GO:0045231 ! slime layer organization + +[Term] +id: GO:0045229 +name: external encapsulating structure organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "external encapsulating structure organisation and biogenesis" EXACT [] +synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0045230 +name: capsule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "capsule organisation and biogenesis" EXACT [] +synonym: "capsule organization and biogenesis" RELATED [] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0045231 +name: slime layer organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "slime layer organisation and biogenesis" EXACT [] +synonym: "slime layer organization and biogenesis" EXACT [] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0045232 +name: S-layer organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai] +synonym: "S-layer organisation and biogenesis" EXACT [] +synonym: "S-layer organization and biogenesis" EXACT [] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0045233 +name: natural killer cell receptor activity +namespace: molecular_function +def: "A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc] +synonym: "Ly49i" NARROW [] +synonym: "NK cell receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane receptor activity + +[Term] +id: GO:0045234 +name: protein palmitoleylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a palmitoleyl moiety to a protein." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0045235 +name: protein amino acid palmitoleylation +namespace: biological_process +def: "The covalent or non-covalent attachment of a palmitoleyl moiety to a protein amino acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0045234 ! protein palmitoleylation + +[Term] +id: GO:0045236 +name: CXCR chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892] +synonym: "alpha chemokine receptor binding" EXACT [] +synonym: "alpha chemokine receptor ligand" NARROW [] +synonym: "C-X-C chemokine receptor ligand" NARROW [] +synonym: "CXC chemokine receptor ligand" NARROW [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0045237 +name: CXCR1 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892] +synonym: "CXCR1 chemokine receptor ligand" NARROW [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0045238 +name: CXCR2 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892] +synonym: "CXCR2 chemokine receptor ligand" NARROW [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0045239 +name: tricarboxylic acid cycle enzyme complex +namespace: cellular_component +def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "TCA cycle enzyme complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045240 +name: alpha-ketoglutarate dehydrogenase complex +namespace: cellular_component +def: "Complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah] +subset: gosubset_prok +synonym: "2-oxoglutarate dehydrogenase complex" EXACT [] +synonym: "dihydrolipoyl dehydrogenase complex" EXACT [] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045241 +name: cytosolic alpha-ketoglutarate dehydrogenase complex +namespace: cellular_component +def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] +synonym: "alpha-ketoglutarate dehydrogenase complex (sensu Bacteria)" EXACT [] +is_a: GO:0045240 ! alpha-ketoglutarate dehydrogenase complex +is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045242 +name: isocitrate dehydrogenase complex (NAD+) +namespace: cellular_component +def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah] +subset: gosubset_prok +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045243 +name: cytosolic isocitrate dehydrogenase complex (NAD+) +namespace: cellular_component +def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "isocitrate dehydrogenase complex (NAD+) (sensu Bacteria)" EXACT [] +is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) +is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045244 +name: succinate-CoA ligase complex (GDP-forming) +namespace: cellular_component +alt_id: GO:0008325 +alt_id: GO:0045245 +def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain and found in eukaryotes. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl] +synonym: "succinate-CoA ligase complex (GDP-forming) (sensu Bacteria)" NARROW [] +synonym: "succinate-CoA ligase complex (GDP-forming) (sensu Eukaryota)" NARROW [] +is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex +is_a: GO:0042709 ! succinate-CoA ligase complex + +[Term] +id: GO:0045246 +name: cytosolic tricarboxylic acid cycle enzyme complex +namespace: cellular_component +def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "TCA cycle enzyme complex (sensu Bacteria)" EXACT [] +synonym: "tricarboxylic acid cycle enzyme complex (sensu Bacteria)" EXACT [] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045247 +name: cytosolic electron transfer flavoprotein complex +namespace: cellular_component +def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "electron transfer flavoprotein complex (sensu Bacteria)" EXACT [] +is_a: GO:0045251 ! electron transfer flavoprotein complex + +[Term] +id: GO:0045248 +name: cytosolic oxoglutarate dehydrogenase complex +namespace: cellular_component +def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, UniProtKB:Q60597] +comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. +subset: gosubset_prok +synonym: "oxoglutarate dehydrogenase complex (sensu Bacteria)" EXACT [] +is_a: GO:0044444 ! cytoplasmic part +is_a: GO:0045252 ! oxoglutarate dehydrogenase complex + +[Term] +id: GO:0045249 +name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex +namespace: cellular_component +def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, UniProtKB:P35816] +comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. +subset: gosubset_prok +synonym: "pyruvate dehydrogenase (lipoamide) phosphatase complex (sensu Bacteria)" EXACT [] +is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex + +[Term] +id: GO:0045250 +name: cytosolic pyruvate dehydrogenase complex +namespace: cellular_component +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. +subset: gosubset_prok +synonym: "pyruvate dehydrogenase complex (lipoamide) (sensu Bacteria)" EXACT [] +synonym: "pyruvate dehydrogenase complex (sensu Bacteria)" EXACT [] +is_a: GO:0045254 ! pyruvate dehydrogenase complex + +[Term] +id: GO:0045251 +name: electron transfer flavoprotein complex +namespace: cellular_component +def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045252 +name: oxoglutarate dehydrogenase complex +namespace: cellular_component +def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [UniProtKB:Q60597] +comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. +subset: goslim_pir +subset: gosubset_prok +synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0045253 +name: pyruvate dehydrogenase (lipoamide) phosphatase complex +namespace: cellular_component +def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [UniProtKB:P35816] +comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045254 +name: pyruvate dehydrogenase complex +namespace: cellular_component +alt_id: GO:0009364 +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. +subset: goslim_pir +subset: gosubset_prok +synonym: "dihydrolipoyl dehydrogenase complex" BROAD [] +synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045257 +name: succinate dehydrogenase complex (ubiquinone) +namespace: cellular_component +def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0045281 ! succinate dehydrogenase complex + +[Term] +id: GO:0045258 +name: plasma membrane succinate dehydrogenase complex (ubiquinone) +namespace: cellular_component +def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684] +subset: gosubset_prok +synonym: "succinate dehydrogenase complex (ubiquinone) (sensu Bacteria)" EXACT [] +is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) +is_a: GO:0045282 ! plasma membrane succinate dehydrogenase complex + +[Term] +id: GO:0045259 +name: proton-transporting ATP synthase complex +namespace: cellular_component +alt_id: GO:0045255 +def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [EC:3.6.3.14, ISBN:0198547684, ISBN:0716743663] +subset: gosubset_prok +synonym: "hydrogen-translocating F-type ATPase complex" EXACT [] +synonym: "hydrogen-transporting ATP synthase complex" EXACT [] +synonym: "proton-transporting F-type ATPase complex" RELATED [] +is_a: GO:0016469 ! proton-transporting two-sector ATPase complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0045260 +name: plasma membrane proton-transporting ATP synthase complex +namespace: cellular_component +alt_id: GO:0045256 +def: "A proton-transporting ATP synthase complex found in the plasma membrane." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684] +subset: gosubset_prok +synonym: "hydrogen-translocating F-type ATPase complex (sensu Bacteria)" EXACT [] +synonym: "hydrogen-transporting ATP synthase" EXACT [] +synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT [] +synonym: "proton-transporting ATP synthase complex (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045259 ! proton-transporting ATP synthase complex + +[Term] +id: GO:0045261 +name: proton-transporting ATP synthase complex, catalytic core F(1) +namespace: cellular_component +def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT [] +is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex + +[Term] +id: GO:0045262 +name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) +namespace: cellular_component +def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled." [GOC:mah, GOC:mtg_sensu, PMID:10838056] +comment: See also the cellular component term 'plasma membrane ; GO:0005886'. +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, F1 sector (sensu Bacteria)" EXACT [] +synonym: "proton-transporting ATP synthase complex, catalytic core F(1) (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) +relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex + +[Term] +id: GO:0045263 +name: proton-transporting ATP synthase complex, coupling factor F(o) +namespace: cellular_component +def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW [] +synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT [] +is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex + +[Term] +id: GO:0045264 +name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) +namespace: cellular_component +def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, F0 sector (sensu Bacteria)" EXACT [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(0) (sensu Bacteria)" EXACT [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(o) (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) +relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex + +[Term] +id: GO:0045265 +name: proton-transporting ATP synthase, stator stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) + +[Term] +id: GO:0045266 +name: plasma membrane proton-transporting ATP synthase, stator stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, stator stalk (sensu Bacteria)" EXACT [] +synonym: "proton-transporting ATP synthase, stator stalk (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk +relationship: part_of GO:0045264 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) + +[Term] +id: GO:0045267 +name: proton-transporting ATP synthase, catalytic core +namespace: cellular_component +def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045268 +name: plasma membrane proton-transporting ATP synthase, catalytic core +namespace: cellular_component +def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, catalytic core (sensu Bacteria)" EXACT [] +synonym: "proton-transporting ATP synthase, catalytic core (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core +relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045269 +name: proton-transporting ATP synthase, central stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045270 +name: plasma membrane proton-transporting ATP synthase, central stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] +subset: gosubset_prok +synonym: "hydrogen-transporting ATP synthase, central stalk (sensu Bacteria)" EXACT [] +synonym: "proton-transporting ATP synthase, central stalk (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk +relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045271 +name: respiratory chain complex I +namespace: cellular_component +alt_id: GO:0045279 +def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:jic, ISBN:0716749556] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. +subset: gosubset_prok +synonym: "electron transport complex I" RELATED [] +synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT [] +synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT [] +synonym: "NADH-Q oxidoreductase complex" EXACT [] +is_a: GO:0030964 ! NADH dehydrogenase complex + +[Term] +id: GO:0045272 +name: plasma membrane respiratory chain complex I +namespace: cellular_component +def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] +subset: gosubset_prok +synonym: "NADH dehydrogenase (ubiquinone) complex (sensu Bacteria)" EXACT [] +synonym: "respiratory chain complex I (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045271 ! respiratory chain complex I + +[Term] +id: GO:0045273 +name: respiratory chain complex II +namespace: cellular_component +def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684] +subset: goslim_pir +subset: gosubset_prok +synonym: "electron transport complex II" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0045274 +name: plasma membrane respiratory chain complex II +namespace: cellular_component +def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684] +subset: gosubset_prok +synonym: "respiratory chain complex II (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045273 ! respiratory chain complex II + +[Term] +id: GO:0045275 +name: respiratory chain complex III +namespace: cellular_component +alt_id: GO:0032842 +alt_id: GO:0045285 +def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733] +subset: goslim_pir +subset: gosubset_prok +synonym: "complex III" EXACT [] +synonym: "cytochrome bc(1) complex" EXACT [] +synonym: "cytochrome bc1 complex" EXACT [] +synonym: "electron transport complex III" RELATED [] +synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT [] +synonym: "ubiquinol-cytochrome-c reductase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +is_a: GO:0044425 ! membrane part + +[Term] +id: GO:0045276 +name: plasma membrane respiratory chain complex III +namespace: cellular_component +alt_id: GO:0045286 +def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] +subset: gosubset_prok +synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT [] +synonym: "respiratory chain complex III (sensu Bacteria)" EXACT [] +synonym: "ubiquinol-cytochrome c oxidoreductase complex (sensu Bacteria)" EXACT [] +synonym: "ubiquinol-cytochrome-c reductase complex (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045275 ! respiratory chain complex III + +[Term] +id: GO:0045277 +name: respiratory chain complex IV +namespace: cellular_component +alt_id: GO:0045287 +def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684] +subset: goslim_pir +subset: gosubset_prok +synonym: "cytochrome c oxidase complex" EXACT [] +synonym: "electron transport complex IV" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0045278 +name: plasma membrane respiratory chain complex IV +namespace: cellular_component +alt_id: GO:0045288 +def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] +subset: gosubset_prok +synonym: "cytochrome c oxidase complex (sensu Bacteria)" EXACT [] +synonym: "respiratory chain complex IV (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045277 ! respiratory chain complex IV + +[Term] +id: GO:0045281 +name: succinate dehydrogenase complex +namespace: cellular_component +def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701] +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0045273 ! respiratory chain complex II + +[Term] +id: GO:0045282 +name: plasma membrane succinate dehydrogenase complex +namespace: cellular_component +def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701] +subset: gosubset_prok +synonym: "succinate dehydrogenase complex (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045281 ! succinate dehydrogenase complex +relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II + +[Term] +id: GO:0045283 +name: fumarate reductase complex +namespace: cellular_component +def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:004224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224] +comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. +subset: gosubset_prok +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0045273 ! respiratory chain complex II + +[Term] +id: GO:0045284 +name: plasma membrane fumarate reductase complex +namespace: cellular_component +def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:003510; InterPro:00224) and D (InterPro:003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224] +comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. +subset: gosubset_prok +synonym: "fumarate reductase complex (sensu Bacteria)" EXACT [] +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0045283 ! fumarate reductase complex +relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II + +[Term] +id: GO:0045289 +name: luciferin monooxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidation of luciferin. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf] +synonym: "luciferase activity" EXACT [] +synonym: "luciferase monooxygenase activity" RELATED [] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0045290 +name: D-arabinose 1-dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose." [EC:1.1.1.117] +synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.117] +xref: EC:1.1.1.117 +xref: MetaCyc:1.1.1.117-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045291 +name: nuclear mRNA trans splicing, SL addition +namespace: biological_process +def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423] +synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT [] +is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome + +[Term] +id: GO:0045292 +name: nuclear mRNA cis splicing, via spliceosome +namespace: biological_process +def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897] +synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [] +is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0045293 +name: mRNA editing complex +namespace: cellular_component +def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607] +subset: goslim_pir +synonym: "editosome" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0045294 +name: alpha-catenin binding +namespace: molecular_function +def: "Interacting selectively with the alpha subunit of the catenin complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045295 +name: gamma-catenin binding +namespace: molecular_function +def: "Interacting selectively with the gamma subunit of the catenin complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045296 +name: cadherin binding +namespace: molecular_function +def: "Interacting selectively with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] +is_a: GO:0050839 ! cell adhesion molecule binding + +[Term] +id: GO:0045297 +name: post-mating behavior +namespace: biological_process +def: "The specific actions or reactions of an organism following mating." [GOC:bf] +synonym: "post-mating behaviour" EXACT [] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0045298 +name: tubulin complex +namespace: cellular_component +def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [http://cancerweb.ncl.ac.uk/, ISBN:0716731363] +is_a: GO:0043234 ! protein complex +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0005874 ! microtubule + +[Term] +id: GO:0045299 +name: otolith mineralization +namespace: biological_process +def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] +is_a: GO:0031214 ! biomineral formation +relationship: part_of GO:0048840 ! otolith development + +[Term] +id: GO:0045300 +name: acyl-[acyl-carrier-protein] desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2] +comment: Note that this function was formerly EC:1.14.99.6. +subset: gosubset_prok +synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT [] +synonym: "acyl-acyl-carrier-protein desaturase activity" EXACT [EC:1.14.19.2] +synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.2] +synonym: "stearyl acyl carrier protein desaturase activity" EXACT [EC:1.14.19.2] +synonym: "stearyl-ACP desaturase activity" EXACT [EC:1.14.19.2] +xref: EC:1.14.19.2 +xref: MetaCyc:1.14.19.2-RXN +xref: MetaCyc:PWY-5147 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0045301 +name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666] +subset: gosubset_prok +synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT [] +synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT [] +synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0045302 +name: choloylglycine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24] +subset: gosubset_prok +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" EXACT [EC:3.5.1.24] +synonym: "bile salt hydrolase activity" EXACT [EC:3.5.1.24] +synonym: "choloyltaurine hydrolase activity" EXACT [EC:3.5.1.24] +synonym: "glycocholase activity" EXACT [EC:3.5.1.24] +xref: EC:3.5.1.24 +xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0045303 +name: diaminobutyrate-2-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde." [EC:2.6.1.76] +subset: gosubset_prok +synonym: "2,4-diaminobutyrate 4-aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "DAB aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "DABA aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "diaminibutyric acid aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "diaminobutyrate transaminase activity" EXACT [EC:2.6.1.76] +synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "EctB" RELATED [EC:2.6.1.76] +synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] +synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76] +xref: EC:2.6.1.76 +xref: MetaCyc:2.6.1.76-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0045304 +name: regulation of establishment of competence for transformation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process by which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg] +subset: gosubset_prok +synonym: "regulator of establishment of competence for transformation activity" RELATED [] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032104 ! regulation of response to extracellular stimulus +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0030420 ! establishment of competence for transformation + +[Term] +id: GO:0045305 +name: regulator of establishment of competence for transformation activity +namespace: molecular_function +def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg] +comment: This term was made obsolete because it does not represent a true function. +is_obsolete: true +replaced_by: GO:0045304 + +[Term] +id: GO:0045306 +name: inhibitor of the establishment of competence for transformation activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg] +comment: This term was made obsolete because it does not represent a true function. +is_obsolete: true +replaced_by: GO:0045808 + +[Term] +id: GO:0045307 +name: activator of the establishment of competence for transformation activity +namespace: molecular_function +def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg] +comment: This term was made obsolete because it does not represent a true function. +is_obsolete: true +replaced_by: GO:0045809 + +[Term] +id: GO:0045309 +name: protein phosphorylated amino acid binding +namespace: molecular_function +def: "Interacting selectively with a phosphorylated amino acid residue within a protein." [GOC:go_curators] +synonym: "phosphoprotein amino acid binding" RELATED [] +is_a: GO:0051219 ! phosphoprotein binding + +[Term] +id: GO:0045310 +name: phosphoserine/phosphothreonine binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators] +comment: This term was made obsolete because it represents two functions. +is_obsolete: true +consider: GO:0050815 +consider: GO:0050816 + +[Term] +id: GO:0045311 +name: filamentous growth in response to pheromones +namespace: biological_process +def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai] +is_a: GO:0019236 ! response to pheromone +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0045312 +name: nor-spermidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators] +synonym: "nor-spermidine anabolism" EXACT [] +synonym: "nor-spermidine biosynthesis" EXACT [] +synonym: "nor-spermidine formation" EXACT [] +synonym: "nor-spermidine synthesis" EXACT [] +is_a: GO:0008295 ! spermidine biosynthetic process +is_a: GO:0046204 ! nor-spermidine metabolic process + +[Term] +id: GO:0045313 +name: rhabdomere membrane biogenesis +namespace: biological_process +def: "The assembly and maintenance of the rhabdomere membrane." [GOC:bf] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0042052 ! rhabdomere development + +[Term] +id: GO:0045314 +name: regulation of compound eye photoreceptor development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] +synonym: "regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +is_a: GO:0042478 ! regulation of eye photoreceptor cell development +relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045315 +name: positive regulation of compound eye photoreceptor development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] +synonym: "activation of eye photoreceptor development (sensu Endopterygota)" NARROW [] +synonym: "positive regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +synonym: "stimulation of eye photoreceptor development (sensu Endopterygota)" NARROW [] +synonym: "up regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +synonym: "up-regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +synonym: "upregulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development +is_a: GO:0045314 ! regulation of compound eye photoreceptor development +relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045316 +name: negative regulation of compound eye photoreceptor development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] +synonym: "down regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +synonym: "down-regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +synonym: "downregulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +synonym: "inhibition of eye photoreceptor development (sensu Endopterygota)" NARROW [] +synonym: "negative regulation of eye photoreceptor development (sensu Endopterygota)" EXACT [] +is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development +is_a: GO:0045314 ! regulation of compound eye photoreceptor development +relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045317 +name: equator specification +namespace: biological_process +def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0042067 ! establishment of ommatidial polarity + +[Term] +id: GO:0045319 +name: SRP-independent cotranslational protein-membrane targeting, translocation +namespace: biological_process +def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai] +comment: This term was made obsolete because there is no evidence for the existence of this process. +synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045320 +name: chloroplast proton-transporting ATP synthase complex +namespace: cellular_component +def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663] +synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT [] +synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT [] +synonym: "hydrogen-translocating F-type ATPase complex (sensu Viridiplantae)" EXACT [] +is_a: GO:0044434 ! chloroplast part +is_a: GO:0044436 ! thylakoid part +is_a: GO:0045259 ! proton-transporting ATP synthase complex +relationship: part_of GO:0009535 ! chloroplast thylakoid membrane + +[Term] +id: GO:0045321 +name: leukocyte activation +namespace: biological_process +def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] +synonym: "immune cell activation" EXACT [] +synonym: "leucocyte activation" EXACT [] +is_a: GO:0001775 ! cell activation +is_a: GO:0002376 ! immune system process + +[Term] +id: GO:0045322 +name: unmethylated CpG binding +namespace: molecular_function +def: "Interacting selectively with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0045323 +name: interleukin-1 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0045324 +name: late endosome to vacuole transport +namespace: biological_process +def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141] +is_a: GO:0007034 ! vacuolar transport +is_a: GO:0016197 ! endosome transport + +[Term] +id: GO:0045325 +name: peptidyl-tryptophan hydroxylation +namespace: biological_process +def: "The posttranslational hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322] +subset: gosubset_prok +xref: RESID:AA0322 +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0045326 +name: DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323] +subset: gosubset_prok +synonym: "DNA-protein covalent cross-linking via the 3' end to peptidyl-tyrosine" EXACT [] +xref: RESID:AA0323 +is_a: GO:0045327 ! DNA-protein covalent cross-linking via peptidyl-tyrosine + +[Term] +id: GO:0045327 +name: DNA-protein covalent cross-linking via peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg] +subset: gosubset_prok +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0045328 +name: cytochrome P450 4A1-heme linkage +namespace: biological_process +def: "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [RESID:AA0324] +subset: gosubset_prok +synonym: "cytochrome P450 4A1-haem linkage" EXACT [] +xref: RESID:AA0324 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0045329 +name: carnitine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carnitine anabolism" EXACT [] +synonym: "carnitine biosynthesis" EXACT [] +synonym: "carnitine formation" EXACT [] +synonym: "carnitine synthesis" EXACT [] +synonym: "vitamin Bt biosynthesis" EXACT [] +synonym: "vitamin Bt biosynthetic process" EXACT [] +xref: Reactome:211693 +xref: Reactome:221464 +xref: Reactome:230091 +xref: Reactome:238113 +xref: Reactome:244711 +xref: Reactome:249628 +xref: Reactome:252421 +xref: Reactome:255582 +xref: Reactome:258958 +xref: Reactome:262331 +xref: Reactome:265179 +xref: Reactome:268307 +xref: Reactome:273997 +xref: Reactome:280477 +xref: Reactome:286495 +xref: Reactome:288252 +xref: Reactome:289796 +xref: Reactome:290349 +xref: Reactome:291701 +xref: Reactome:292371 +xref: Reactome:293677 +xref: Reactome:71262 +is_a: GO:0009437 ! carnitine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0045330 +name: aspartyl esterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, SP_KW:KW-0063] +subset: gosubset_prok +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0045331 +name: coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2] +comment: This term was made obsolete because it represents two activities. +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT [] +synonym: "heterodisulfide reductase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051911 +replaced_by: GO:0051912 + +[Term] +id: GO:0045332 +name: phospholipid translocation +namespace: biological_process +def: "The translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, ISBN:0815316194, PMID:16452632] +subset: gosubset_prok +synonym: "flippase" RELATED [] +is_a: GO:0015914 ! phospholipid transport +is_a: GO:0016044 ! membrane organization +is_a: GO:0034204 ! lipid translocation + +[Term] +id: GO:0045333 +name: cellular respiration +namespace: biological_process +def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [ISBN:0140513590, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "oxidative metabolic process" EXACT [] +synonym: "oxidative metabolism" EXACT [] +synonym: "respiration" BROAD [] +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + +[Term] +id: GO:0045334 +name: clathrin-coated endocytic vesicle +namespace: cellular_component +def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] +is_a: GO:0030136 ! clathrin-coated vesicle +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0045335 +name: phagocytic vesicle +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "phagosome" EXACT [] +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0045336 +name: clathrin-coated phagocytic vesicle +namespace: cellular_component +def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "clathrin-coated phagosome" EXACT [] +is_a: GO:0045334 ! clathrin-coated endocytic vesicle +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0045337 +name: farnesyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl] +subset: gosubset_prok +synonym: "farnesyl diphosphate anabolism" EXACT [] +synonym: "farnesyl diphosphate biosynthesis" EXACT [] +synonym: "farnesyl diphosphate formation" EXACT [] +synonym: "farnesyl diphosphate synthesis" EXACT [] +xref: MetaCyc:PWY-5123 +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0045338 ! farnesyl diphosphate metabolic process + +[Term] +id: GO:0045338 +name: farnesyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators] +subset: gosubset_prok +synonym: "farnesyl diphosphate metabolism" EXACT [] +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0045339 +name: farnesyl diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "farnesyl diphosphate breakdown" EXACT [] +synonym: "farnesyl diphosphate catabolism" EXACT [] +synonym: "farnesyl diphosphate degradation" EXACT [] +is_a: GO:0016095 ! polyprenol catabolic process +is_a: GO:0045338 ! farnesyl diphosphate metabolic process + +[Term] +id: GO:0045340 +name: mercury ion binding +namespace: molecular_function +def: "Interacting selectively with mercury (Hg) ions." [GOC:go_curators] +subset: gosubset_prok +synonym: "mercury binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0045341 +name: MHC class I biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators] +synonym: "major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "MHC class I anabolism" EXACT [] +synonym: "MHC class I biosynthesis" EXACT [] +synonym: "MHC class I formation" EXACT [] +synonym: "MHC class I synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0045342 +name: MHC class II biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators] +synonym: "major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "MHC class II anabolism" EXACT [] +synonym: "MHC class II biosynthesis" EXACT [] +synonym: "MHC class II formation" EXACT [] +synonym: "MHC class II synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0045343 +name: regulation of MHC class I biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] +synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "regulation of MHC class I anabolism" EXACT [] +synonym: "regulation of MHC class I biosynthesis" EXACT [] +synonym: "regulation of MHC class I formation" EXACT [] +synonym: "regulation of MHC class I synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045341 ! MHC class I biosynthetic process + +[Term] +id: GO:0045344 +name: negative regulation of MHC class I biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] +synonym: "down regulation of MHC class I biosynthetic process" EXACT [] +synonym: "down-regulation of MHC class I biosynthetic process" EXACT [] +synonym: "downregulation of MHC class I biosynthetic process" EXACT [] +synonym: "inhibition of MHC class I biosynthetic process" NARROW [] +synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "negative regulation of MHC class I anabolism" EXACT [] +synonym: "negative regulation of MHC class I biosynthesis" EXACT [] +synonym: "negative regulation of MHC class I formation" EXACT [] +synonym: "negative regulation of MHC class I synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045343 ! regulation of MHC class I biosynthetic process +relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process + +[Term] +id: GO:0045345 +name: positive regulation of MHC class I biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] +synonym: "activation of MHC class I biosynthetic process" NARROW [] +synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "positive regulation of MHC class I anabolism" EXACT [] +synonym: "positive regulation of MHC class I biosynthesis" EXACT [] +synonym: "positive regulation of MHC class I formation" EXACT [] +synonym: "positive regulation of MHC class I synthesis" EXACT [] +synonym: "stimulation of MHC class I biosynthetic process" NARROW [] +synonym: "up regulation of MHC class I biosynthetic process" EXACT [] +synonym: "up-regulation of MHC class I biosynthetic process" EXACT [] +synonym: "upregulation of MHC class I biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045343 ! regulation of MHC class I biosynthetic process +relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process + +[Term] +id: GO:0045346 +name: regulation of MHC class II biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] +synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "regulation of MHC class II anabolism" EXACT [] +synonym: "regulation of MHC class II biosynthesis" EXACT [] +synonym: "regulation of MHC class II formation" EXACT [] +synonym: "regulation of MHC class II synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045342 ! MHC class II biosynthetic process + +[Term] +id: GO:0045347 +name: negative regulation of MHC class II biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] +synonym: "down regulation of MHC class II biosynthetic process" EXACT [] +synonym: "down-regulation of MHC class II biosynthetic process" EXACT [] +synonym: "downregulation of MHC class II biosynthetic process" EXACT [] +synonym: "inhibition of MHC class II biosynthetic process" NARROW [] +synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "negative regulation of MHC class II anabolism" EXACT [] +synonym: "negative regulation of MHC class II biosynthesis" EXACT [] +synonym: "negative regulation of MHC class II formation" EXACT [] +synonym: "negative regulation of MHC class II synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045346 ! regulation of MHC class II biosynthetic process +relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process + +[Term] +id: GO:0045348 +name: positive regulation of MHC class II biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] +synonym: "activation of MHC class II biosynthetic process" NARROW [] +synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "positive regulation of MHC class II anabolism" EXACT [] +synonym: "positive regulation of MHC class II biosynthesis" EXACT [] +synonym: "positive regulation of MHC class II formation" EXACT [] +synonym: "positive regulation of MHC class II synthesis" EXACT [] +synonym: "stimulation of MHC class II biosynthetic process" NARROW [] +synonym: "up regulation of MHC class II biosynthetic process" EXACT [] +synonym: "up-regulation of MHC class II biosynthetic process" EXACT [] +synonym: "upregulation of MHC class II biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045346 ! regulation of MHC class II biosynthetic process +relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process + +[Term] +id: GO:0045349 +name: interferon-alpha biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] +synonym: "IFN-alpha biosynthesis" EXACT [] +synonym: "IFN-alpha biosynthetic process" EXACT [] +synonym: "interferon-alpha anabolism" EXACT [] +synonym: "interferon-alpha biosynthesis" EXACT [] +synonym: "interferon-alpha formation" EXACT [] +synonym: "interferon-alpha synthesis" EXACT [] +is_a: GO:0045351 ! type I interferon biosynthetic process +relationship: part_of GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0045350 +name: interferon-beta biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] +synonym: "IFN-beta biosynthesis" EXACT [] +synonym: "IFN-beta biosynthetic process" EXACT [] +synonym: "interferon-beta anabolism" EXACT [] +synonym: "interferon-beta biosynthesis" EXACT [] +synonym: "interferon-beta formation" EXACT [] +synonym: "interferon-beta synthesis" EXACT [] +is_a: GO:0045351 ! type I interferon biosynthetic process +relationship: part_of GO:0032608 ! interferon-beta production + +[Term] +id: GO:0045351 +name: type I interferon biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add] +synonym: "interferon type I biosynthetic process" EXACT [] +synonym: "type I interferon anabolism" EXACT [] +synonym: "type I interferon biosynthesis" EXACT [] +synonym: "type I interferon formation" EXACT [] +synonym: "type I interferon synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032606 ! type I interferon production + +[Term] +id: GO:0045352 +name: interleukin-1 Type I receptor antagonist activity +namespace: molecular_function +def: "Blocks the binding of interleukin-1 to interleukin-1 Type I receptors." [GOC:ebc] +synonym: "IL-1ra type I" EXACT [] +is_a: GO:0005152 ! interleukin-1 receptor antagonist activity + +[Term] +id: GO:0045353 +name: interleukin-1 Type II receptor antagonist activity +namespace: molecular_function +def: "Blocks the binding of interleukin-1 to interleukin-1 Type II receptors." [GOC:ebc] +synonym: "IL-1ra type II" EXACT [] +is_a: GO:0005152 ! interleukin-1 receptor antagonist activity + +[Term] +id: GO:0045354 +name: regulation of interferon-alpha biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] +synonym: "regulation of interferon-alpha anabolism" EXACT [] +synonym: "regulation of interferon-alpha biosynthesis" EXACT [] +synonym: "regulation of interferon-alpha formation" EXACT [] +synonym: "regulation of interferon-alpha synthesis" EXACT [] +is_a: GO:0032647 ! regulation of interferon-alpha production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process + +[Term] +id: GO:0045355 +name: negative regulation of interferon-alpha biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] +synonym: "down regulation of interferon-alpha biosynthetic process" EXACT [] +synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT [] +synonym: "downregulation of interferon-alpha biosynthetic process" EXACT [] +synonym: "inhibition of interferon-alpha biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-alpha anabolism" EXACT [] +synonym: "negative regulation of interferon-alpha biosynthesis" EXACT [] +synonym: "negative regulation of interferon-alpha formation" EXACT [] +synonym: "negative regulation of interferon-alpha synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process +relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process + +[Term] +id: GO:0045356 +name: positive regulation of interferon-alpha biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators] +synonym: "activation of interferon-alpha biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-alpha anabolism" EXACT [] +synonym: "positive regulation of interferon-alpha biosynthesis" EXACT [] +synonym: "positive regulation of interferon-alpha formation" EXACT [] +synonym: "positive regulation of interferon-alpha synthesis" EXACT [] +synonym: "stimulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "up regulation of interferon-alpha biosynthetic process" EXACT [] +synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT [] +synonym: "upregulation of interferon-alpha biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process +relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process + +[Term] +id: GO:0045357 +name: regulation of interferon-beta biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] +synonym: "regulation of interferon-beta anabolism" EXACT [] +synonym: "regulation of interferon-beta biosynthesis" EXACT [] +synonym: "regulation of interferon-beta formation" EXACT [] +synonym: "regulation of interferon-beta synthesis" EXACT [] +is_a: GO:0032648 ! regulation of interferon-beta production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045350 ! interferon-beta biosynthetic process + +[Term] +id: GO:0045358 +name: negative regulation of interferon-beta biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] +synonym: "down regulation of interferon-beta biosynthetic process" EXACT [] +synonym: "down-regulation of interferon-beta biosynthetic process" EXACT [] +synonym: "downregulation of interferon-beta biosynthetic process" EXACT [] +synonym: "inhibition of interferon-beta biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-beta anabolism" EXACT [] +synonym: "negative regulation of interferon-beta biosynthesis" EXACT [] +synonym: "negative regulation of interferon-beta formation" EXACT [] +synonym: "negative regulation of interferon-beta synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process +relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process + +[Term] +id: GO:0045359 +name: positive regulation of interferon-beta biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators] +synonym: "activation of interferon-beta biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-beta anabolism" EXACT [] +synonym: "positive regulation of interferon-beta biosynthesis" EXACT [] +synonym: "positive regulation of interferon-beta formation" EXACT [] +synonym: "positive regulation of interferon-beta synthesis" EXACT [] +synonym: "stimulation of interferon-beta biosynthetic process" NARROW [] +synonym: "up regulation of interferon-beta biosynthetic process" EXACT [] +synonym: "up-regulation of interferon-beta biosynthetic process" EXACT [] +synonym: "upregulation of interferon-beta biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process +relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process + +[Term] +id: GO:0045360 +name: regulation of interleukin-1 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] +synonym: "regulation of IL-1 biosynthesis" EXACT [] +synonym: "regulation of IL-1 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-1 anabolism" EXACT [] +synonym: "regulation of interleukin-1 biosynthesis" EXACT [] +synonym: "regulation of interleukin-1 formation" EXACT [] +synonym: "regulation of interleukin-1 synthesis" EXACT [] +is_a: GO:0032652 ! regulation of interleukin-1 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process + +[Term] +id: GO:0045361 +name: negative regulation of interleukin-1 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] +synonym: "down regulation of interleukin-1 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-1 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-1 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-1 biosynthesis" EXACT [] +synonym: "negative regulation of IL-1 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-1 anabolism" EXACT [] +synonym: "negative regulation of interleukin-1 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-1 formation" EXACT [] +synonym: "negative regulation of interleukin-1 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process +relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process + +[Term] +id: GO:0045362 +name: positive regulation of interleukin-1 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators] +synonym: "activation of interleukin-1 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-1 biosynthesis" EXACT [] +synonym: "positive regulation of IL-1 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-1 anabolism" EXACT [] +synonym: "positive regulation of interleukin-1 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-1 formation" EXACT [] +synonym: "positive regulation of interleukin-1 synthesis" EXACT [] +synonym: "stimulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-1 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-1 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process +relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process + +[Term] +id: GO:0045363 +name: regulation of interleukin-11 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] +synonym: "regulation of IL-11 biosynthesis" EXACT [] +synonym: "regulation of IL-11 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-11 anabolism" EXACT [] +synonym: "regulation of interleukin-11 biosynthesis" EXACT [] +synonym: "regulation of interleukin-11 formation" EXACT [] +synonym: "regulation of interleukin-11 synthesis" EXACT [] +is_a: GO:0032654 ! regulation of interleukin-11 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process + +[Term] +id: GO:0045364 +name: negative regulation of interleukin-11 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] +synonym: "down regulation of interleukin-11 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-11 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-11 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-11 biosynthesis" EXACT [] +synonym: "negative regulation of IL-11 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-11 anabolism" EXACT [] +synonym: "negative regulation of interleukin-11 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-11 formation" EXACT [] +synonym: "negative regulation of interleukin-11 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process +relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process + +[Term] +id: GO:0045365 +name: positive regulation of interleukin-11 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators] +synonym: "activation of interleukin-11 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-11 biosynthesis" EXACT [] +synonym: "positive regulation of IL-11 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-11 anabolism" EXACT [] +synonym: "positive regulation of interleukin-11 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-11 formation" EXACT [] +synonym: "positive regulation of interleukin-11 synthesis" EXACT [] +synonym: "stimulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-11 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-11 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process +relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process + +[Term] +id: GO:0045366 +name: regulation of interleukin-13 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] +synonym: "regulation of IL-13 biosynthesis" EXACT [] +synonym: "regulation of IL-13 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-13 anabolism" EXACT [] +synonym: "regulation of interleukin-13 biosynthesis" EXACT [] +synonym: "regulation of interleukin-13 formation" EXACT [] +synonym: "regulation of interleukin-13 synthesis" EXACT [] +is_a: GO:0032656 ! regulation of interleukin-13 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process + +[Term] +id: GO:0045367 +name: negative regulation of interleukin-13 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] +synonym: "down regulation of interleukin-13 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-13 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-13 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-13 biosynthesis" EXACT [] +synonym: "negative regulation of IL-13 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-13 anabolism" EXACT [] +synonym: "negative regulation of interleukin-13 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-13 formation" EXACT [] +synonym: "negative regulation of interleukin-13 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process +relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process + +[Term] +id: GO:0045368 +name: positive regulation of interleukin-13 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators] +synonym: "activation of interleukin-13 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-13 biosynthesis" EXACT [] +synonym: "positive regulation of IL-13 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-13 anabolism" EXACT [] +synonym: "positive regulation of interleukin-13 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-13 formation" EXACT [] +synonym: "positive regulation of interleukin-13 synthesis" EXACT [] +synonym: "stimulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-13 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-13 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process +relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process + +[Term] +id: GO:0045369 +name: regulation of interleukin-14 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] +synonym: "regulation of IL-14 biosynthesis" EXACT [] +synonym: "regulation of IL-14 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-14 anabolism" EXACT [] +synonym: "regulation of interleukin-14 biosynthesis" EXACT [] +synonym: "regulation of interleukin-14 formation" EXACT [] +synonym: "regulation of interleukin-14 synthesis" EXACT [] +is_a: GO:0032657 ! regulation of interleukin-14 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process + +[Term] +id: GO:0045370 +name: negative regulation of interleukin-14 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] +synonym: "down regulation of interleukin-14 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-14 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-14 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-14 biosynthesis" EXACT [] +synonym: "negative regulation of IL-14 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-14 anabolism" EXACT [] +synonym: "negative regulation of interleukin-14 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-14 formation" EXACT [] +synonym: "negative regulation of interleukin-14 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process +relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process + +[Term] +id: GO:0045371 +name: positive regulation of interleukin-14 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators] +synonym: "activation of interleukin-14 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-14 biosynthesis" EXACT [] +synonym: "positive regulation of IL-14 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-14 anabolism" EXACT [] +synonym: "positive regulation of interleukin-14 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-14 formation" EXACT [] +synonym: "positive regulation of interleukin-14 synthesis" EXACT [] +synonym: "stimulation of interleukin-14 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-14 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-14 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process +relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process + +[Term] +id: GO:0045372 +name: regulation of interleukin-15 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] +synonym: "regulation of IL-15 biosynthesis" EXACT [] +synonym: "regulation of IL-15 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-15 anabolism" EXACT [] +synonym: "regulation of interleukin-15 biosynthesis" EXACT [] +synonym: "regulation of interleukin-15 formation" EXACT [] +synonym: "regulation of interleukin-15 synthesis" EXACT [] +is_a: GO:0032658 ! regulation of interleukin-15 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process + +[Term] +id: GO:0045373 +name: negative regulation of interleukin-15 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] +synonym: "down regulation of interleukin-15 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-15 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-15 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-15 biosynthesis" EXACT [] +synonym: "negative regulation of IL-15 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-15 anabolism" EXACT [] +synonym: "negative regulation of interleukin-15 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-15 formation" EXACT [] +synonym: "negative regulation of interleukin-15 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process +relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process + +[Term] +id: GO:0045374 +name: positive regulation of interleukin-15 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators] +synonym: "activation of interleukin-15 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-15 biosynthesis" EXACT [] +synonym: "positive regulation of IL-15 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-15 anabolism" EXACT [] +synonym: "positive regulation of interleukin-15 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-15 formation" EXACT [] +synonym: "positive regulation of interleukin-15 synthesis" EXACT [] +synonym: "stimulation of interleukin-15 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-15 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-15 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process +relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process + +[Term] +id: GO:0045375 +name: regulation of interleukin-16 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] +synonym: "regulation of IL-16 biosynthesis" EXACT [] +synonym: "regulation of IL-16 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-16 anabolism" EXACT [] +synonym: "regulation of interleukin-16 biosynthesis" EXACT [] +synonym: "regulation of interleukin-16 formation" EXACT [] +synonym: "regulation of interleukin-16 synthesis" EXACT [] +is_a: GO:0032659 ! regulation of interleukin-16 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process + +[Term] +id: GO:0045376 +name: negative regulation of interleukin-16 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] +synonym: "down regulation of interleukin-16 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-16 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-16 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-16 biosynthesis" EXACT [] +synonym: "negative regulation of IL-16 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-16 anabolism" EXACT [] +synonym: "negative regulation of interleukin-16 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-16 formation" EXACT [] +synonym: "negative regulation of interleukin-16 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process +relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process + +[Term] +id: GO:0045377 +name: positive regulation of interleukin-16 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators] +synonym: "activation of interleukin-16 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-16 biosynthesis" EXACT [] +synonym: "positive regulation of IL-16 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-16 anabolism" EXACT [] +synonym: "positive regulation of interleukin-16 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-16 formation" EXACT [] +synonym: "positive regulation of interleukin-16 synthesis" EXACT [] +synonym: "stimulation of interleukin-16 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-16 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-16 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process +relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process + +[Term] +id: GO:0045378 +name: regulation of interleukin-17 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] +synonym: "regulation of IL-17 biosynthesis" EXACT [] +synonym: "regulation of IL-17 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-17 anabolism" EXACT [] +synonym: "regulation of interleukin-17 biosynthesis" EXACT [] +synonym: "regulation of interleukin-17 formation" EXACT [] +synonym: "regulation of interleukin-17 synthesis" EXACT [] +is_a: GO:0032660 ! regulation of interleukin-17 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process + +[Term] +id: GO:0045379 +name: negative regulation of interleukin-17 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] +synonym: "down regulation of interleukin-17 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-17 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-17 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-17 biosynthesis" EXACT [] +synonym: "negative regulation of IL-17 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-17 anabolism" EXACT [] +synonym: "negative regulation of interleukin-17 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-17 formation" EXACT [] +synonym: "negative regulation of interleukin-17 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process +relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process + +[Term] +id: GO:0045380 +name: positive regulation of interleukin-17 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators] +synonym: "activation of interleukin-17 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-17 biosynthesis" EXACT [] +synonym: "positive regulation of IL-17 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-17 anabolism" EXACT [] +synonym: "positive regulation of interleukin-17 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-17 formation" EXACT [] +synonym: "positive regulation of interleukin-17 synthesis" EXACT [] +synonym: "stimulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-17 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-17 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process +relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process + +[Term] +id: GO:0045381 +name: regulation of interleukin-18 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] +synonym: "regulation of IL-18 biosynthesis" EXACT [] +synonym: "regulation of IL-18 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-18 anabolism" EXACT [] +synonym: "regulation of interleukin-18 biosynthesis" EXACT [] +synonym: "regulation of interleukin-18 formation" EXACT [] +synonym: "regulation of interleukin-18 synthesis" EXACT [] +is_a: GO:0032661 ! regulation of interleukin-18 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process + +[Term] +id: GO:0045382 +name: negative regulation of interleukin-18 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] +synonym: "down regulation of interleukin-18 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-18 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-18 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-18 biosynthesis" EXACT [] +synonym: "negative regulation of IL-18 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-18 anabolism" EXACT [] +synonym: "negative regulation of interleukin-18 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-18 formation" EXACT [] +synonym: "negative regulation of interleukin-18 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process +relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process + +[Term] +id: GO:0045383 +name: positive regulation of interleukin-18 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators] +synonym: "activation of interleukin-18 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-18 biosynthesis" EXACT [] +synonym: "positive regulation of IL-18 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-18 anabolism" EXACT [] +synonym: "positive regulation of interleukin-18 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-18 formation" EXACT [] +synonym: "positive regulation of interleukin-18 synthesis" EXACT [] +synonym: "stimulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-18 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-18 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process +relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process + +[Term] +id: GO:0045384 +name: regulation of interleukin-19 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] +synonym: "regulation of IL-19 biosynthesis" EXACT [] +synonym: "regulation of IL-19 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-19 anabolism" EXACT [] +synonym: "regulation of interleukin-19 biosynthesis" EXACT [] +synonym: "regulation of interleukin-19 formation" EXACT [] +synonym: "regulation of interleukin-19 synthesis" EXACT [] +is_a: GO:0032662 ! regulation of interleukin-19 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process + +[Term] +id: GO:0045385 +name: negative regulation of interleukin-19 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] +synonym: "down regulation of interleukin-19 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-19 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-19 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-19 biosynthesis" EXACT [] +synonym: "negative regulation of IL-19 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-19 anabolism" EXACT [] +synonym: "negative regulation of interleukin-19 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-19 formation" EXACT [] +synonym: "negative regulation of interleukin-19 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process +relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process + +[Term] +id: GO:0045386 +name: positive regulation of interleukin-19 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators] +synonym: "activation of interleukin-19 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-19 biosynthesis" EXACT [] +synonym: "positive regulation of IL-19 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-19 anabolism" EXACT [] +synonym: "positive regulation of interleukin-19 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-19 formation" EXACT [] +synonym: "positive regulation of interleukin-19 synthesis" EXACT [] +synonym: "stimulation of interleukin-19 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-19 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-19 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process +relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process + +[Term] +id: GO:0045387 +name: regulation of interleukin-20 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] +synonym: "regulation of IL-20 biosynthesis" EXACT [] +synonym: "regulation of IL-20 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-20 anabolism" EXACT [] +synonym: "regulation of interleukin-20 biosynthesis" EXACT [] +synonym: "regulation of interleukin-20 formation" EXACT [] +synonym: "regulation of interleukin-20 synthesis" EXACT [] +is_a: GO:0032664 ! regulation of interleukin-20 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process + +[Term] +id: GO:0045388 +name: negative regulation of interleukin-20 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] +synonym: "down regulation of interleukin-20 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-20 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-20 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-20 biosynthesis" EXACT [] +synonym: "negative regulation of IL-20 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-20 anabolism" EXACT [] +synonym: "negative regulation of interleukin-20 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-20 formation" EXACT [] +synonym: "negative regulation of interleukin-20 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process +relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process + +[Term] +id: GO:0045389 +name: positive regulation of interleukin-20 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators] +synonym: "activation of interleukin-20 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-20 biosynthesis" EXACT [] +synonym: "positive regulation of IL-20 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-20 anabolism" EXACT [] +synonym: "positive regulation of interleukin-20 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-20 formation" EXACT [] +synonym: "positive regulation of interleukin-20 synthesis" EXACT [] +synonym: "stimulation of interleukin-20 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-20 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-20 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process +relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process + +[Term] +id: GO:0045390 +name: regulation of interleukin-21 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] +synonym: "regulation of IL-21 biosynthesis" EXACT [] +synonym: "regulation of IL-21 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-21 anabolism" EXACT [] +synonym: "regulation of interleukin-21 biosynthesis" EXACT [] +synonym: "regulation of interleukin-21 formation" EXACT [] +synonym: "regulation of interleukin-21 synthesis" EXACT [] +is_a: GO:0032665 ! regulation of interleukin-21 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process + +[Term] +id: GO:0045391 +name: negative regulation of interleukin-21 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] +synonym: "down regulation of interleukin-21 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-21 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-21 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-21 biosynthesis" EXACT [] +synonym: "negative regulation of IL-21 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-21 anabolism" EXACT [] +synonym: "negative regulation of interleukin-21 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-21 formation" EXACT [] +synonym: "negative regulation of interleukin-21 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process +relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process + +[Term] +id: GO:0045392 +name: positive regulation of interleukin-21 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators] +synonym: "activation of interleukin-21 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-21 biosynthesis" EXACT [] +synonym: "positive regulation of IL-21 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-21 anabolism" EXACT [] +synonym: "positive regulation of interleukin-21 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-21 formation" EXACT [] +synonym: "positive regulation of interleukin-21 synthesis" EXACT [] +synonym: "stimulation of interleukin-21 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-21 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-21 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process +relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process + +[Term] +id: GO:0045393 +name: regulation of interleukin-22 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] +synonym: "regulation of IL-22 biosynthesis" EXACT [] +synonym: "regulation of IL-22 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-22 anabolism" EXACT [] +synonym: "regulation of interleukin-22 biosynthesis" EXACT [] +synonym: "regulation of interleukin-22 formation" EXACT [] +synonym: "regulation of interleukin-22 synthesis" EXACT [] +is_a: GO:0032666 ! regulation of interleukin-22 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process + +[Term] +id: GO:0045394 +name: negative regulation of interleukin-22 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] +synonym: "down regulation of interleukin-22 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-22 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-22 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-22 biosynthesis" EXACT [] +synonym: "negative regulation of IL-22 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-22 anabolism" EXACT [] +synonym: "negative regulation of interleukin-22 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-22 formation" EXACT [] +synonym: "negative regulation of interleukin-22 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process +relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process + +[Term] +id: GO:0045395 +name: positive regulation of interleukin-22 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators] +synonym: "activation of interleukin-22 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-22 biosynthesis" EXACT [] +synonym: "positive regulation of IL-22 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-22 anabolism" EXACT [] +synonym: "positive regulation of interleukin-22 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-22 formation" EXACT [] +synonym: "positive regulation of interleukin-22 synthesis" EXACT [] +synonym: "stimulation of interleukin-22 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-22 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-22 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process +relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process + +[Term] +id: GO:0045396 +name: regulation of interleukin-23 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] +synonym: "regulation of IL-23 biosynthesis" EXACT [] +synonym: "regulation of IL-23 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-23 anabolism" EXACT [] +synonym: "regulation of interleukin-23 biosynthesis" EXACT [] +synonym: "regulation of interleukin-23 formation" EXACT [] +synonym: "regulation of interleukin-23 synthesis" EXACT [] +is_a: GO:0032667 ! regulation of interleukin-23 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process + +[Term] +id: GO:0045397 +name: negative regulation of interleukin-23 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] +synonym: "down regulation of interleukin-23 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-23 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-23 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-23 biosynthesis" EXACT [] +synonym: "negative regulation of IL-23 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-23 anabolism" EXACT [] +synonym: "negative regulation of interleukin-23 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-23 formation" EXACT [] +synonym: "negative regulation of interleukin-23 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process +relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process + +[Term] +id: GO:0045398 +name: positive regulation of interleukin-23 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators] +synonym: "activation of interleukin-23 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-23 biosynthesis" EXACT [] +synonym: "positive regulation of IL-23 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-23 anabolism" EXACT [] +synonym: "positive regulation of interleukin-23 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-23 formation" EXACT [] +synonym: "positive regulation of interleukin-23 synthesis" EXACT [] +synonym: "stimulation of interleukin-23 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-23 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-23 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process +relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process + +[Term] +id: GO:0045399 +name: regulation of interleukin-3 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] +synonym: "regulation of IL-3 biosynthesis" EXACT [] +synonym: "regulation of IL-3 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-3 anabolism" EXACT [] +synonym: "regulation of interleukin-3 biosynthesis" EXACT [] +synonym: "regulation of interleukin-3 formation" EXACT [] +synonym: "regulation of interleukin-3 synthesis" EXACT [] +is_a: GO:0032672 ! regulation of interleukin-3 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process + +[Term] +id: GO:0045400 +name: negative regulation of interleukin-3 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] +synonym: "down regulation of interleukin-3 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-3 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-3 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-3 biosynthesis" EXACT [] +synonym: "negative regulation of IL-3 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-3 anabolism" EXACT [] +synonym: "negative regulation of interleukin-3 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-3 formation" EXACT [] +synonym: "negative regulation of interleukin-3 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process +relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process + +[Term] +id: GO:0045401 +name: positive regulation of interleukin-3 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators] +synonym: "activation of interleukin-3 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-3 biosynthesis" EXACT [] +synonym: "positive regulation of IL-3 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-3 anabolism" EXACT [] +synonym: "positive regulation of interleukin-3 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-3 formation" EXACT [] +synonym: "positive regulation of interleukin-3 synthesis" EXACT [] +synonym: "stimulation of interleukin-3 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-3 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-3 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process +relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process + +[Term] +id: GO:0045402 +name: regulation of interleukin-4 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] +synonym: "regulation of IL-4 biosynthesis" EXACT [] +synonym: "regulation of IL-4 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-4 anabolism" EXACT [] +synonym: "regulation of interleukin-4 biosynthesis" EXACT [] +synonym: "regulation of interleukin-4 formation" EXACT [] +synonym: "regulation of interleukin-4 synthesis" EXACT [] +is_a: GO:0032673 ! regulation of interleukin-4 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process + +[Term] +id: GO:0045403 +name: negative regulation of interleukin-4 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] +synonym: "down regulation of interleukin-4 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-4 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-4 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-4 biosynthesis" EXACT [] +synonym: "negative regulation of IL-4 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-4 anabolism" EXACT [] +synonym: "negative regulation of interleukin-4 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-4 formation" EXACT [] +synonym: "negative regulation of interleukin-4 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process +relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process + +[Term] +id: GO:0045404 +name: positive regulation of interleukin-4 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators] +synonym: "activation of interleukin-4 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-4 biosynthesis" EXACT [] +synonym: "positive regulation of IL-4 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-4 anabolism" EXACT [] +synonym: "positive regulation of interleukin-4 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-4 formation" EXACT [] +synonym: "positive regulation of interleukin-4 synthesis" EXACT [] +synonym: "stimulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-4 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-4 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process +relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process + +[Term] +id: GO:0045405 +name: regulation of interleukin-5 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] +synonym: "regulation of IL-5 biosynthesis" EXACT [] +synonym: "regulation of IL-5 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-5 anabolism" EXACT [] +synonym: "regulation of interleukin-5 biosynthesis" EXACT [] +synonym: "regulation of interleukin-5 formation" EXACT [] +synonym: "regulation of interleukin-5 synthesis" EXACT [] +is_a: GO:0032674 ! regulation of interleukin-5 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process + +[Term] +id: GO:0045406 +name: negative regulation of interleukin-5 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] +synonym: "down regulation of interleukin-5 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-5 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-5 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-5 biosynthesis" EXACT [] +synonym: "negative regulation of IL-5 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-5 anabolism" EXACT [] +synonym: "negative regulation of interleukin-5 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-5 formation" EXACT [] +synonym: "negative regulation of interleukin-5 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process +relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process + +[Term] +id: GO:0045407 +name: positive regulation of interleukin-5 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators] +synonym: "activation of interleukin-5 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-5 biosynthesis" EXACT [] +synonym: "positive regulation of IL-5 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-5 anabolism" EXACT [] +synonym: "positive regulation of interleukin-5 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-5 formation" EXACT [] +synonym: "positive regulation of interleukin-5 synthesis" EXACT [] +synonym: "stimulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-5 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-5 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process +relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process + +[Term] +id: GO:0045408 +name: regulation of interleukin-6 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] +synonym: "regulation of IL-6 biosynthesis" EXACT [] +synonym: "regulation of IL-6 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-6 anabolism" EXACT [] +synonym: "regulation of interleukin-6 biosynthesis" EXACT [] +synonym: "regulation of interleukin-6 formation" EXACT [] +synonym: "regulation of interleukin-6 synthesis" EXACT [] +is_a: GO:0032675 ! regulation of interleukin-6 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process + +[Term] +id: GO:0045409 +name: negative regulation of interleukin-6 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] +synonym: "down regulation of interleukin-6 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-6 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-6 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-6 biosynthesis" EXACT [] +synonym: "negative regulation of IL-6 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-6 anabolism" EXACT [] +synonym: "negative regulation of interleukin-6 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-6 formation" EXACT [] +synonym: "negative regulation of interleukin-6 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process +relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process + +[Term] +id: GO:0045410 +name: positive regulation of interleukin-6 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators] +synonym: "activation of interleukin-6 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-6 biosynthesis" EXACT [] +synonym: "positive regulation of IL-6 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-6 anabolism" EXACT [] +synonym: "positive regulation of interleukin-6 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-6 formation" EXACT [] +synonym: "positive regulation of interleukin-6 synthesis" EXACT [] +synonym: "stimulation of interleukin-6 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-6 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-6 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process +relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process + +[Term] +id: GO:0045411 +name: regulation of interleukin-7 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] +synonym: "regulation of IL-7 biosynthesis" EXACT [] +synonym: "regulation of IL-7 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-7 anabolism" EXACT [] +synonym: "regulation of interleukin-7 biosynthesis" EXACT [] +synonym: "regulation of interleukin-7 formation" EXACT [] +synonym: "regulation of interleukin-7 synthesis" EXACT [] +is_a: GO:0032676 ! regulation of interleukin-7 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process + +[Term] +id: GO:0045412 +name: negative regulation of interleukin-7 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] +synonym: "down regulation of interleukin-7 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-7 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-7 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-7 biosynthesis" EXACT [] +synonym: "negative regulation of IL-7 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-7 anabolism" EXACT [] +synonym: "negative regulation of interleukin-7 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-7 formation" EXACT [] +synonym: "negative regulation of interleukin-7 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process +relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process + +[Term] +id: GO:0045413 +name: positive regulation of interleukin-7 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators] +synonym: "activation of interleukin-7 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-7 biosynthesis" EXACT [] +synonym: "positive regulation of IL-7 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-7 anabolism" EXACT [] +synonym: "positive regulation of interleukin-7 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-7 formation" EXACT [] +synonym: "positive regulation of interleukin-7 synthesis" EXACT [] +synonym: "stimulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-7 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-7 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process +relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process + +[Term] +id: GO:0045414 +name: regulation of interleukin-8 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] +synonym: "regulation of IL-8 biosynthesis" EXACT [] +synonym: "regulation of IL-8 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-8 anabolism" EXACT [] +synonym: "regulation of interleukin-8 biosynthesis" EXACT [] +synonym: "regulation of interleukin-8 formation" EXACT [] +synonym: "regulation of interleukin-8 synthesis" EXACT [] +is_a: GO:0032677 ! regulation of interleukin-8 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process + +[Term] +id: GO:0045415 +name: negative regulation of interleukin-8 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] +synonym: "down regulation of interleukin-8 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-8 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-8 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-8 biosynthesis" EXACT [] +synonym: "negative regulation of IL-8 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-8 anabolism" EXACT [] +synonym: "negative regulation of interleukin-8 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-8 formation" EXACT [] +synonym: "negative regulation of interleukin-8 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process +relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process + +[Term] +id: GO:0045416 +name: positive regulation of interleukin-8 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators] +synonym: "activation of interleukin-8 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-8 biosynthesis" EXACT [] +synonym: "positive regulation of IL-8 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-8 anabolism" EXACT [] +synonym: "positive regulation of interleukin-8 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-8 formation" EXACT [] +synonym: "positive regulation of interleukin-8 synthesis" EXACT [] +synonym: "stimulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-8 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-8 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process +relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process + +[Term] +id: GO:0045417 +name: regulation of interleukin-9 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] +synonym: "regulation of IL-9 biosynthesis" EXACT [] +synonym: "regulation of IL-9 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-9 anabolism" EXACT [] +synonym: "regulation of interleukin-9 biosynthesis" EXACT [] +synonym: "regulation of interleukin-9 formation" EXACT [] +synonym: "regulation of interleukin-9 synthesis" EXACT [] +is_a: GO:0032678 ! regulation of interleukin-9 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process + +[Term] +id: GO:0045418 +name: negative regulation of interleukin-9 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] +synonym: "down regulation of interleukin-9 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-9 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-9 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-9 biosynthesis" EXACT [] +synonym: "negative regulation of IL-9 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-9 anabolism" EXACT [] +synonym: "negative regulation of interleukin-9 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-9 formation" EXACT [] +synonym: "negative regulation of interleukin-9 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process +relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process + +[Term] +id: GO:0045419 +name: positive regulation of interleukin-9 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators] +synonym: "activation of interleukin-9 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-9 biosynthesis" EXACT [] +synonym: "positive regulation of IL-9 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-9 anabolism" EXACT [] +synonym: "positive regulation of interleukin-9 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-9 formation" EXACT [] +synonym: "positive regulation of interleukin-9 synthesis" EXACT [] +synonym: "stimulation of interleukin-9 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-9 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-9 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process +relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process + +[Term] +id: GO:0045420 +name: regulation of connective tissue growth factor biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] +synonym: "regulation of connective tissue growth factor anabolism" EXACT [] +synonym: "regulation of connective tissue growth factor biosynthesis" EXACT [] +synonym: "regulation of connective tissue growth factor formation" EXACT [] +synonym: "regulation of connective tissue growth factor synthesis" EXACT [] +is_a: GO:0032643 ! regulation of connective tissue growth factor production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process + +[Term] +id: GO:0045421 +name: negative regulation of connective tissue growth factor biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] +synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT [] +synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT [] +synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT [] +synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW [] +synonym: "negative regulation of connective tissue growth factor anabolism" EXACT [] +synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT [] +synonym: "negative regulation of connective tissue growth factor formation" EXACT [] +synonym: "negative regulation of connective tissue growth factor synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process +relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process + +[Term] +id: GO:0045422 +name: positive regulation of connective tissue growth factor biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators] +synonym: "activation of connective tissue growth factor biosynthetic process" NARROW [] +synonym: "positive regulation of connective tissue growth factor anabolism" EXACT [] +synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT [] +synonym: "positive regulation of connective tissue growth factor formation" EXACT [] +synonym: "positive regulation of connective tissue growth factor synthesis" EXACT [] +synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW [] +synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT [] +synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT [] +synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process +relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process + +[Term] +id: GO:0045423 +name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] +synonym: "regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] +synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] +synonym: "regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] +synonym: "regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] +is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process + +[Term] +id: GO:0045424 +name: negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] +synonym: "down regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] +synonym: "down-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] +synonym: "downregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] +synonym: "inhibition of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +synonym: "negative regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] +synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] +synonym: "negative regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] +synonym: "negative regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process +relationship: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process + +[Term] +id: GO:0045425 +name: positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators] +synonym: "activation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +synonym: "positive regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT [] +synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT [] +synonym: "positive regulation of granulocyte macrophage colony-stimulating factor formation" EXACT [] +synonym: "positive regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT [] +synonym: "stimulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +synonym: "up regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] +synonym: "up-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] +synonym: "upregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process +relationship: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process + +[Term] +id: GO:0045426 +name: quinone cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any quinone cofactor, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1)." [GOC:mb] +subset: gosubset_prok +synonym: "quinone cofactor anabolism" EXACT [] +synonym: "quinone cofactor biosynthesis" EXACT [] +synonym: "quinone cofactor formation" EXACT [] +synonym: "quinone cofactor synthesis" EXACT [] +is_a: GO:0009108 ! coenzyme biosynthetic process +is_a: GO:0042375 ! quinone cofactor metabolic process + +[Term] +id: GO:0045427 +name: enzyme active site formation via (phospho-5'-guanosine)-L-histidine +namespace: biological_process +def: "The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325] +subset: gosubset_prok +xref: RESID:AA0325 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0045428 +name: regulation of nitric oxide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] +synonym: "regulation of nitric oxide anabolism" EXACT [] +synonym: "regulation of nitric oxide biosynthesis" EXACT [] +synonym: "regulation of nitric oxide formation" EXACT [] +synonym: "regulation of nitric oxide synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0006809 ! nitric oxide biosynthetic process + +[Term] +id: GO:0045429 +name: positive regulation of nitric oxide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] +synonym: "activation of nitric oxide biosynthetic process" NARROW [] +synonym: "positive regulation of nitric oxide anabolism" EXACT [] +synonym: "positive regulation of nitric oxide biosynthesis" EXACT [] +synonym: "positive regulation of nitric oxide formation" EXACT [] +synonym: "positive regulation of nitric oxide synthesis" EXACT [] +synonym: "stimulation of nitric oxide biosynthetic process" NARROW [] +synonym: "up regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "up-regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "upregulation of nitric oxide biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process + +[Term] +id: GO:0045430 +name: chalcone isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6] +synonym: "chalcone--flavonone isomerase activity" EXACT [EC:5.5.1.6] +synonym: "chalcone-flavanone isomerase activity" EXACT [] +synonym: "flavanone lyase (decyclizing)" EXACT [EC:5.5.1.6] +xref: EC:5.5.1.6 +xref: MetaCyc:CHALCONE-ISOMERASE-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0045431 +name: flavonol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.11.23, ISBN:0943088372, PMID:7904213] +synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.23] +synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" EXACT [EC:1.14.11.23] +synonym: "FLS activity" RELATED [EC:1.14.11.23] +xref: EC:1.14.11.23 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0045433 +name: male courtship behavior, veined wing generated song production +namespace: biological_process +def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior (sensu Insecta), song production" RELATED [] +synonym: "male courtship behaviour (sensu Insecta), song production" EXACT [] +synonym: "male courtship behaviour, veined wing generated song production" EXACT [] +is_a: GO:0008049 ! male courtship behavior +relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration + +[Term] +id: GO:0045434 +name: negative regulation of female receptivity, post-mating +namespace: biological_process +def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] +synonym: "down regulation of female receptivity, post-mating" EXACT [] +synonym: "down-regulation of female receptivity, post-mating" EXACT [] +synonym: "downregulation of female receptivity, post-mating" EXACT [] +synonym: "inhibition of female receptivity, post-mating" NARROW [] +is_a: GO:0007621 ! negative regulation of female receptivity +is_a: GO:0046008 ! regulation of female receptivity, post-mating + +[Term] +id: GO:0045435 +name: lycopene epsilon cyclase activity +namespace: molecular_function +def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512] +synonym: "lycopene cyclase" BROAD [] +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0045436 +name: lycopene beta cyclase activity +namespace: molecular_function +def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512] +subset: gosubset_prok +synonym: "crtL" RELATED [] +synonym: "lycopene cyclase" BROAD [] +xref: MetaCyc:RXN1F-150 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0045437 +name: uridine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: uridine + H2O = D-ribose + uracil." [EC:3.2.2.3] +subset: gosubset_prok +synonym: "uridine hydrolase activity" EXACT [] +synonym: "uridine ribohydrolase activity" EXACT [EC:3.2.2.3] +xref: EC:3.2.2.3 +xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0045438 +name: L-cysteinyl-D-valine synthetase activity +namespace: molecular_function +def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333] +synonym: "ACV synthetase activity" BROAD [] +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0045439 +name: isopenicillin-N epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopenicillin-N = penicillin-N." [EC:5.1.1.17, KEGG_PATHWAY:map00311] +subset: gosubset_prok +synonym: "isopenicillin N epimerase activity" EXACT [] +synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" EXACT [EC:5.1.1.17] +xref: EC:5.1.1.17 +xref: MetaCyc:5.1.1.17-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0045441 +name: deacetoxycephalosporin C synthetase activity +namespace: molecular_function +def: "Catalysis of the formation of deacetoxycephalosporin from penicillin-N." [KEGG_PATHWAY:map00311] +synonym: "DAOCS" EXACT [] +synonym: "expandase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0045442 +name: deacetoxycephalosporin-C hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: deacetoxycephalosporin C + 2-oxoglutarate + O2 = deacetylcephalosporin C + succinate + CO2." [EC:1.14.11.26] +synonym: "3'-methylcephem hydroxylase activity" EXACT [EC:1.14.11.26] +synonym: "beta-lactam hydroxylase activity" EXACT [] +synonym: "DACS" RELATED [EC:1.14.11.26] +synonym: "DAOC hydroxylase activity" EXACT [EC:1.14.11.26] +synonym: "deacetoxycephalosporin C hydroxylase activity" EXACT [EC:1.14.11.26] +synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.26] +synonym: "deacetylcephalosporin C synthase activity" EXACT [EC:1.14.11.26] +xref: EC:1.14.11.26 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0045443 +name: juvenile hormone secretion +namespace: biological_process +def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0045444 +name: fat cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +synonym: "adipocyte cell differentiation" EXACT [] +synonym: "adipocyte differentiation" EXACT [] +synonym: "adipogenesis" EXACT [] +synonym: "adipose cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0045445 +name: myoblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk] +synonym: "myoblast cell differentiation" EXACT [] +is_a: GO:0042692 ! muscle cell differentiation +relationship: part_of GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0045446 +name: endothelial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0045448 +name: mitotic cell cycle, embryonic +namespace: biological_process +def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] +is_a: GO:0000278 ! mitotic cell cycle +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0045449 +name: regulation of transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0006350 ! transcription + +[Term] +id: GO:0045450 +name: bicoid mRNA localization +namespace: biological_process +def: "Any process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] +synonym: "establishment and maintenance of bicoid mRNA localization" EXACT [] +is_a: GO:0008298 ! intracellular mRNA localization +relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification + +[Term] +id: GO:0045451 +name: pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] +synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT [] +synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT [] +synonym: "oocyte pole plasm oskar mRNA localization" EXACT [] +is_a: GO:0019094 ! pole plasm mRNA localization + +[Term] +id: GO:0045453 +name: bone resorption +namespace: biological_process +def: "The process by which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780] +is_a: GO:0001894 ! tissue homeostasis +relationship: part_of GO:0046849 ! bone remodeling + +[Term] +id: GO:0045454 +name: cell redox homeostasis +namespace: biological_process +alt_id: GO:0030503 +alt_id: GO:0045867 +alt_id: GO:0045868 +def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "regulation of cell redox homeostasis" EXACT [] +synonym: "regulation of redox homeostasis" BROAD [] +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0045455 +name: ecdysteroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ecdysteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0042445 ! hormone metabolic process +relationship: part_of GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0045456 +name: ecdysteroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] +synonym: "ecdysteroid anabolism" EXACT [] +synonym: "ecdysteroid biosynthesis" EXACT [] +synonym: "ecdysteroid formation" EXACT [] +synonym: "ecdysteroid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0045457 +name: ecdysteroid secretion +namespace: biological_process +def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0045458 +name: recombination within rDNA repeats +namespace: biological_process +def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: Note that this term was reinstated from obsolete. +subset: gosubset_prok +synonym: "recombination within ribosomal DNA repeats" EXACT [] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0043007 ! maintenance of rDNA + +[Term] +id: GO:0045459 +name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT [] +xref: RESID:AA0326 +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0045460 +name: sterigmatocystin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "sterigmatocystin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0045461 +name: sterigmatocystin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "sterigmatocystin anabolism" EXACT [] +synonym: "sterigmatocystin biosynthesis" EXACT [] +synonym: "sterigmatocystin formation" EXACT [] +synonym: "sterigmatocystin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0045460 ! sterigmatocystin metabolic process + +[Term] +id: GO:0045462 +name: trichothecene 3-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973] +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0045463 +name: R8 cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045464 +name: R8 cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] +is_a: GO:0043704 ! photoreceptor cell fate specification +relationship: part_of GO:0007460 ! R8 cell fate commitment + +[Term] +id: GO:0045465 +name: R8 cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0045466 +name: R7 cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0045467 +name: R7 cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045468 +name: regulation of R8 cell spacing in compound eye +namespace: biological_process +def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339] +synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of R8 spacing" EXACT [GOC:dph] +is_a: GO:0007389 ! pattern specification process +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0048749 ! compound eye development + +[Term] +id: GO:0045469 +name: negative regulation of R8 cell spacing in compound eye +namespace: biological_process +def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339] +synonym: "down regulation of R8 spacing" EXACT [] +synonym: "down-regulation of R8 spacing" EXACT [] +synonym: "downregulation of R8 spacing" EXACT [] +synonym: "inhibition of R8 spacing" NARROW [] +is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye + +[Term] +id: GO:0045470 +name: R8 cell-mediated photoreceptor organization +namespace: biological_process +def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339] +synonym: "R8-mediated photoreceptor organisation" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045471 +name: response to ethanol +namespace: biological_process +alt_id: GO:0017036 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0045472 +name: response to ether +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0045473 +name: response to ethanol (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jic] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +is_obsolete: true +consider: GO:0048149 + +[Term] +id: GO:0045474 +name: response to ether (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jic] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +is_obsolete: true +consider: GO:0048150 + +[Term] +id: GO:0045475 +name: locomotor rhythm +namespace: biological_process +def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] +synonym: "circadian locomotor activity rhythm" NARROW [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0048512 ! circadian behavior + +[Term] +id: GO:0045476 +name: nurse cell apoptosis +namespace: biological_process +def: "The process by which nurse cells undergo apoptosis. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptosis." [PMID:11973306] +synonym: "apoptosis of nurse cells" EXACT [] +synonym: "nurse cell programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of nurse cells by apoptosis" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0045477 +name: regulation of nurse cell apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nurse cell apoptosis." [PMID:11973306] +is_a: GO:0042981 ! regulation of apoptosis +relationship: regulates GO:0045476 ! nurse cell apoptosis + +[Term] +id: GO:0045478 +name: fusome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "fusome organisation and biogenesis" EXACT [] +synonym: "fusome organization and biogenesis" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0045479 +name: vesicle targeting to fusome +namespace: biological_process +def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244] +synonym: "vesicle-fusome targeting" EXACT [] +is_a: GO:0006903 ! vesicle targeting +relationship: part_of GO:0045478 ! fusome organization + +[Term] +id: GO:0045480 +name: galactose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + H2O2." [EC:1.1.3.9] +synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9] +synonym: "D-galactose oxidase activity" EXACT [EC:1.1.3.9] +synonym: "D-galactose:oxygen 6-oxidoreductase activity" EXACT [EC:1.1.3.9] +xref: EC:1.1.3.9 +xref: MetaCyc:GALACTOSE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0045481 +name: 6-endo-hydroxycineole dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + NADH + H+." [EC:1.1.1.241] +synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.241] +xref: EC:1.1.1.241 +xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045482 +name: trichodiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = trichodiene + diphosphate." [EC:4.2.3.6] +synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6] +synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" EXACT [EC:4.2.3.6] +synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" EXACT [EC:4.2.3.6] +synonym: "trichodiene synthetase activity" EXACT [EC:4.2.3.6] +xref: EC:4.2.3.6 +xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0045483 +name: aristolochene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] +synonym: "5-epi-aristolochene synthase activity" EXACT [EC:4.2.3.9] +synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9] +synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" EXACT [EC:4.2.3.9] +synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9] +xref: EC:4.2.3.9 +xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0045484 +name: L-lysine 6-transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde + L-glutamate." [EC:2.6.1.36] +subset: gosubset_prok +synonym: "L-lysine aminotransferase activity" EXACT [EC:2.6.1.36] +synonym: "L-lysine transaminase activity" EXACT [EC:2.6.1.36] +synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] +synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.36] +synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] +synonym: "lysine 6-aminotransferase activity" EXACT [] +synonym: "lysine epsilon-aminotransferase activity" EXACT [EC:2.6.1.36] +synonym: "lysine epsilon-transaminase activity" EXACT [EC:2.6.1.36] +synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36] +xref: EC:2.6.1.36 +xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0045485 +name: omega-6 fatty acid desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0045486 +name: naringenin 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9] +synonym: "(2S)-flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] +synonym: "flavanone 3-beta-hydroxylase activity" EXACT [EC:1.14.11.9] +synonym: "flavanone 3-dioxygenase activity" EXACT [EC:1.14.11.9] +synonym: "flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9] +synonym: "flavanone 3beta-hydroxylase activity" EXACT [EC:1.14.11.9] +synonym: "flavanone synthase I activity" EXACT [EC:1.14.11.9] +synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.9] +synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9] +synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9] +xref: EC:1.14.11.9 +xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0045487 +name: gibberellin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators] +subset: gosubset_prok +synonym: "gibberellic acid breakdown" NARROW [] +synonym: "gibberellic acid catabolic process" NARROW [] +synonym: "gibberellic acid catabolism" NARROW [] +synonym: "gibberellic acid degradation" NARROW [] +synonym: "gibberellin catabolism" EXACT [] +is_a: GO:0009685 ! gibberellin metabolic process +is_a: GO:0016103 ! diterpenoid catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0045488 +name: pectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators] +subset: gosubset_prok +synonym: "pectin metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0045489 +name: pectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] +subset: gosubset_prok +synonym: "pectin anabolism" EXACT [] +synonym: "pectin biosynthesis" EXACT [] +synonym: "pectin formation" EXACT [] +synonym: "pectin synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0045488 ! pectin metabolic process + +[Term] +id: GO:0045490 +name: pectin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] +subset: gosubset_prok +synonym: "pectin breakdown" EXACT [] +synonym: "pectin catabolism" EXACT [] +synonym: "pectin degradation" EXACT [] +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0045488 ! pectin metabolic process + +[Term] +id: GO:0045491 +name: xylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] +subset: gosubset_prok +synonym: "xylan metabolism" EXACT [] +is_a: GO:0010410 ! hemicellulose metabolic process + +[Term] +id: GO:0045492 +name: xylan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] +subset: gosubset_prok +synonym: "xylan anabolism" EXACT [] +synonym: "xylan biosynthesis" EXACT [] +synonym: "xylan formation" EXACT [] +synonym: "xylan synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0045493 +name: xylan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] +subset: gosubset_prok +synonym: "xylan breakdown" EXACT [] +synonym: "xylan catabolism" EXACT [] +synonym: "xylan degradation" EXACT [] +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0045494 +name: photoreceptor cell maintenance +namespace: biological_process +def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [GOC:bf, http://cancerweb.ncl.ac.uk/] +is_a: GO:0060249 ! anatomical structure homeostasis +relationship: part_of GO:0007601 ! visual perception + +[Term] +id: GO:0045495 +name: pole plasm +namespace: cellular_component +def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, http://cancerweb.ncl.ac.uk/] +synonym: "germ plasm" NARROW [] +synonym: "polar plasm" EXACT [] +is_a: GO:0005737 ! cytoplasm + +[Term] +id: GO:0045496 +name: male analia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [GOC:mtg_sensu, PMID:11494318] +synonym: "male analia development (sensu Endopterygota)" EXACT [] +is_a: GO:0007487 ! analia development + +[Term] +id: GO:0045497 +name: female analia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [GOC:mtg_sensu, PMID:11494318] +synonym: "female analia development (sensu Endopterygota)" EXACT [] +is_a: GO:0007487 ! analia development + +[Term] +id: GO:0045498 +name: sex comb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0045499 +name: chemorepellent activity +namespace: molecular_function +def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "chemorepellant activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0045500 +name: sevenless signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the sevenless receptor binding to one of its physiological ligands." [GOC:bf] +synonym: "sev receptor signaling pathway" EXACT [] +synonym: "sev signaling pathway" EXACT [] +synonym: "sevenless signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: part_of GO:0007465 ! R7 cell fate commitment + +[Term] +id: GO:0045501 +name: regulation of sevenless signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] +synonym: "regulation of sev signaling pathway" EXACT [] +synonym: "regulation of sevenless signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0045676 ! regulation of R7 cell differentiation +relationship: regulates GO:0045500 ! sevenless signaling pathway + +[Term] +id: GO:0045502 +name: dynein binding +namespace: molecular_function +def: "Interacting selectively with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045503 +name: dynein light chain binding +namespace: molecular_function +def: "Interacting selectively with a light chain of the dynein complex." [GOC:bf] +is_a: GO:0045502 ! dynein binding + +[Term] +id: GO:0045504 +name: dynein heavy chain binding +namespace: molecular_function +def: "Interacting selectively with a heavy chain of the dynein complex." [GOC:bf] +is_a: GO:0045502 ! dynein binding + +[Term] +id: GO:0045505 +name: dynein intermediate chain binding +namespace: molecular_function +def: "Interacting selectively with an intermediate chain of the dynein complex." [GOC:bf] +is_a: GO:0045502 ! dynein binding + +[Term] +id: GO:0045506 +name: interleukin-24 receptor activity +namespace: molecular_function +def: "Combining with interleukin-24 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-24R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0045510 ! interleukin-24 binding + +[Term] +id: GO:0045507 +name: interleukin-25 receptor activity +namespace: molecular_function +def: "Combining with interleukin-25 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-25R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0045511 ! interleukin-25 binding + +[Term] +id: GO:0045508 +name: interleukin-26 receptor activity +namespace: molecular_function +def: "Combining with interleukin-26 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-26R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0045512 ! interleukin-26 binding + +[Term] +id: GO:0045509 +name: interleukin-27 receptor activity +namespace: molecular_function +def: "Combining with interleukin-27 to initiate a change in cell activity." [GOC:jl] +synonym: "IL-27R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity +is_a: GO:0045513 ! interleukin-27 binding + +[Term] +id: GO:0045510 +name: interleukin-24 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-24." [GOC:go_curators] +synonym: "IL-24 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0045511 +name: interleukin-25 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-25." [GOC:go_curators] +synonym: "IL-25 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0045512 +name: interleukin-26 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-26." [GOC:go_curators] +synonym: "IL-26 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0045513 +name: interleukin-27 binding +namespace: molecular_function +def: "Interacting selectively with interleukin-27." [GOC:go_curators] +synonym: "IL-27 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0045514 +name: interleukin-16 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-16 receptor." [GOC:go_curators] +synonym: "IL-16" NARROW [] +synonym: "interleukin-16 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045515 +name: interleukin-18 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-18 receptor." [GOC:go_curators] +synonym: "IL-18" NARROW [] +synonym: "interleukin-18 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045516 +name: interleukin-19 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-19 receptor." [GOC:go_curators] +synonym: "IL-19" NARROW [] +synonym: "interleukin-19 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045517 +name: interleukin-20 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-20 receptor." [GOC:go_curators] +synonym: "IL-20" NARROW [] +synonym: "interleukin-20 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045518 +name: interleukin-22 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-22 receptor." [GOC:go_curators] +synonym: "IL-22" NARROW [] +synonym: "interleukin-22 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045519 +name: interleukin-23 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-23 receptor." [GOC:go_curators] +synonym: "IL-23" NARROW [] +synonym: "interleukin-23 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045520 +name: interleukin-24 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-24 receptor." [GOC:go_curators] +synonym: "IL-24" NARROW [] +synonym: "interleukin-24 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045521 +name: interleukin-25 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-25 receptor." [GOC:go_curators] +synonym: "IL-25" NARROW [] +synonym: "interleukin-25 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045522 +name: interleukin-26 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-26 receptor." [GOC:go_curators] +synonym: "IL-26" NARROW [] +synonym: "interleukin-26 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045523 +name: interleukin-27 receptor binding +namespace: molecular_function +def: "Interacting selectively with the interleukin-27 receptor." [GOC:go_curators] +synonym: "IL-27" NARROW [] +synonym: "interleukin-27 receptor ligand" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0045524 +name: interleukin-24 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] +synonym: "IL-24 biosynthesis" EXACT [] +synonym: "IL-24 biosynthetic process" EXACT [] +synonym: "interleukin-24 anabolism" EXACT [] +synonym: "interleukin-24 biosynthesis" EXACT [] +synonym: "interleukin-24 formation" EXACT [] +synonym: "interleukin-24 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0045525 +name: interleukin-25 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] +synonym: "IL-25 biosynthesis" EXACT [] +synonym: "IL-25 biosynthetic process" EXACT [] +synonym: "interleukin-25 anabolism" EXACT [] +synonym: "interleukin-25 biosynthesis" EXACT [] +synonym: "interleukin-25 formation" EXACT [] +synonym: "interleukin-25 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0045526 +name: interleukin-26 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] +synonym: "IL-26 biosynthesis" EXACT [] +synonym: "IL-26 biosynthetic process" EXACT [] +synonym: "interleukin-26 anabolism" EXACT [] +synonym: "interleukin-26 biosynthesis" EXACT [] +synonym: "interleukin-26 formation" EXACT [] +synonym: "interleukin-26 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0045527 +name: interleukin-27 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] +synonym: "IL-27 biosynthesis" EXACT [] +synonym: "IL-27 biosynthetic process" EXACT [] +synonym: "interleukin-27 anabolism" EXACT [] +synonym: "interleukin-27 biosynthesis" EXACT [] +synonym: "interleukin-27 formation" EXACT [] +synonym: "interleukin-27 synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0045528 +name: regulation of interleukin-24 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] +synonym: "regulation of IL-24 biosynthesis" EXACT [] +synonym: "regulation of IL-24 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-24 anabolism" EXACT [] +synonym: "regulation of interleukin-24 biosynthesis" EXACT [] +synonym: "regulation of interleukin-24 formation" EXACT [] +synonym: "regulation of interleukin-24 synthesis" EXACT [] +is_a: GO:0032668 ! regulation of interleukin-24 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process + +[Term] +id: GO:0045529 +name: regulation of interleukin-25 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] +synonym: "regulation of IL-25 biosynthesis" EXACT [] +synonym: "regulation of IL-25 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-25 anabolism" EXACT [] +synonym: "regulation of interleukin-25 biosynthesis" EXACT [] +synonym: "regulation of interleukin-25 formation" EXACT [] +synonym: "regulation of interleukin-25 synthesis" EXACT [] +is_a: GO:0032669 ! regulation of interleukin-25 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process + +[Term] +id: GO:0045530 +name: regulation of interleukin-26 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] +synonym: "regulation of IL-26 biosynthesis" EXACT [] +synonym: "regulation of IL-26 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-26 anabolism" EXACT [] +synonym: "regulation of interleukin-26 biosynthesis" EXACT [] +synonym: "regulation of interleukin-26 formation" EXACT [] +synonym: "regulation of interleukin-26 synthesis" EXACT [] +is_a: GO:0032670 ! regulation of interleukin-26 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process + +[Term] +id: GO:0045531 +name: regulation of interleukin-27 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] +synonym: "regulation of IL-27 biosynthesis" EXACT [] +synonym: "regulation of IL-27 biosynthetic process" EXACT [] +synonym: "regulation of interleukin-27 anabolism" EXACT [] +synonym: "regulation of interleukin-27 biosynthesis" EXACT [] +synonym: "regulation of interleukin-27 formation" EXACT [] +synonym: "regulation of interleukin-27 synthesis" EXACT [] +is_a: GO:0032671 ! regulation of interleukin-27 production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process + +[Term] +id: GO:0045532 +name: negative regulation of interleukin-24 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] +synonym: "down regulation of interleukin-24 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-24 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-24 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-24 biosynthesis" EXACT [] +synonym: "negative regulation of IL-24 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-24 anabolism" EXACT [] +synonym: "negative regulation of interleukin-24 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-24 formation" EXACT [] +synonym: "negative regulation of interleukin-24 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process +relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process + +[Term] +id: GO:0045533 +name: negative regulation of interleukin-25 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] +synonym: "down regulation of interleukin-25 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-25 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-25 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-25 biosynthesis" EXACT [] +synonym: "negative regulation of IL-25 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-25 anabolism" EXACT [] +synonym: "negative regulation of interleukin-25 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-25 formation" EXACT [] +synonym: "negative regulation of interleukin-25 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process +relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process + +[Term] +id: GO:0045534 +name: negative regulation of interleukin-26 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] +synonym: "down regulation of interleukin-26 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-26 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-26 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-26 biosynthesis" EXACT [] +synonym: "negative regulation of IL-26 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-26 anabolism" EXACT [] +synonym: "negative regulation of interleukin-26 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-26 formation" EXACT [] +synonym: "negative regulation of interleukin-26 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process +relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process + +[Term] +id: GO:0045535 +name: negative regulation of interleukin-27 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] +synonym: "down regulation of interleukin-27 biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-27 biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-27 biosynthetic process" NARROW [] +synonym: "negative regulation of IL-27 biosynthesis" EXACT [] +synonym: "negative regulation of IL-27 biosynthetic process" EXACT [] +synonym: "negative regulation of interleukin-27 anabolism" EXACT [] +synonym: "negative regulation of interleukin-27 biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-27 formation" EXACT [] +synonym: "negative regulation of interleukin-27 synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process +relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process + +[Term] +id: GO:0045536 +name: positive regulation of interleukin-24 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators] +synonym: "activation of interleukin-24 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-24 biosynthesis" EXACT [] +synonym: "positive regulation of IL-24 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-24 anabolism" EXACT [] +synonym: "positive regulation of interleukin-24 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-24 formation" EXACT [] +synonym: "positive regulation of interleukin-24 synthesis" EXACT [] +synonym: "stimulation of interleukin-24 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-24 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-24 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process +relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process + +[Term] +id: GO:0045537 +name: positive regulation of interleukin-25 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators] +synonym: "activation of interleukin-25 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-25 biosynthesis" EXACT [] +synonym: "positive regulation of IL-25 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-25 anabolism" EXACT [] +synonym: "positive regulation of interleukin-25 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-25 formation" EXACT [] +synonym: "positive regulation of interleukin-25 synthesis" EXACT [] +synonym: "stimulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-25 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-25 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process +relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process + +[Term] +id: GO:0045538 +name: positive regulation of interleukin-26 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators] +synonym: "activation of interleukin-26 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-26 biosynthesis" EXACT [] +synonym: "positive regulation of IL-26 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-26 anabolism" EXACT [] +synonym: "positive regulation of interleukin-26 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-26 formation" EXACT [] +synonym: "positive regulation of interleukin-26 synthesis" EXACT [] +synonym: "stimulation of interleukin-26 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-26 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-26 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process +relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process + +[Term] +id: GO:0045539 +name: positive regulation of interleukin-27 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators] +synonym: "activation of interleukin-27 biosynthetic process" NARROW [] +synonym: "positive regulation of IL-27 biosynthesis" EXACT [] +synonym: "positive regulation of IL-27 biosynthetic process" EXACT [] +synonym: "positive regulation of interleukin-27 anabolism" EXACT [] +synonym: "positive regulation of interleukin-27 biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-27 formation" EXACT [] +synonym: "positive regulation of interleukin-27 synthesis" EXACT [] +synonym: "stimulation of interleukin-27 biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-27 biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-27 biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process +relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process + +[Term] +id: GO:0045540 +name: regulation of cholesterol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] +synonym: "regulation of cholesterol anabolism" EXACT [] +synonym: "regulation of cholesterol biosynthesis" EXACT [] +synonym: "regulation of cholesterol formation" EXACT [] +synonym: "regulation of cholesterol synthesis" EXACT [] +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0045541 +name: negative regulation of cholesterol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] +synonym: "down regulation of cholesterol biosynthetic process" EXACT [] +synonym: "down-regulation of cholesterol biosynthetic process" EXACT [] +synonym: "downregulation of cholesterol biosynthetic process" EXACT [] +synonym: "inhibition of cholesterol biosynthetic process" NARROW [] +synonym: "negative regulation of cholesterol anabolism" EXACT [] +synonym: "negative regulation of cholesterol biosynthesis" EXACT [] +synonym: "negative regulation of cholesterol formation" EXACT [] +synonym: "negative regulation of cholesterol synthesis" EXACT [] +is_a: GO:0045540 ! regulation of cholesterol biosynthetic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0045542 +name: positive regulation of cholesterol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] +synonym: "activation of cholesterol biosynthetic process" NARROW [] +synonym: "positive regulation of cholesterol anabolism" EXACT [] +synonym: "positive regulation of cholesterol biosynthesis" EXACT [] +synonym: "positive regulation of cholesterol formation" EXACT [] +synonym: "positive regulation of cholesterol synthesis" EXACT [] +synonym: "stimulation of cholesterol biosynthetic process" NARROW [] +synonym: "up regulation of cholesterol biosynthetic process" EXACT [] +synonym: "up-regulation of cholesterol biosynthetic process" EXACT [] +synonym: "upregulation of cholesterol biosynthetic process" EXACT [] +is_a: GO:0045540 ! regulation of cholesterol biosynthetic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0045543 +name: gibberellin 2-beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin 1 + 2-oxoglutarate + O2 = 2-beta-hydroxygibberellin 1 + succinate + CO2." [EC:1.14.11.13] +synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [EC:1.14.11.13] +synonym: "gibberellin 2-beta-hydroxylase activity" EXACT [EC:1.14.11.13] +synonym: "gibberellin 2-oxidase activity" EXACT [] +synonym: "gibberellin 2beta-dioxygenase activity" EXACT [EC:1.14.11.13] +synonym: "gibberellin 2beta-hydroxylase activity" EXACT [EC:1.14.11.13] +xref: EC:1.14.11.13 +xref: MetaCyc:GIBBERELLIN-2-BETA-DIOXYGENASE-RXN +xref: MetaCyc:PWY-102 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0045544 +name: gibberellin 20-oxidase activity +namespace: molecular_function +def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047] +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0045545 +name: syndecan binding +namespace: molecular_function +def: "Interacting selectively with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045547 +name: dehydrodolichyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0045548 +name: phenylalanine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3." [EC:4.3.1.5] +synonym: "L-phenylalanine ammonia-lyase (trans-cinnamate-forming)" EXACT [EC:4.3.1.5] +synonym: "L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.5] +synonym: "L-tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5] +synonym: "PAL" RELATED [EC:4.3.1.5] +synonym: "phenylalanine ammonium-lyase activity" EXACT [EC:4.3.1.5] +synonym: "phenylalanine deaminase activity" EXACT [EC:4.3.1.5] +synonym: "tyrase activity" EXACT [EC:4.3.1.5] +synonym: "tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5] +xref: EC:4.3.1.5 +xref: MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0045549 +name: 9-cis-epoxycarotenoid dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal and 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51] +synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" EXACT [EC:1.13.11.51] +synonym: "AtNCED3" RELATED [EC:1.13.11.51] +synonym: "NCED" RELATED [EC:1.13.11.51] +synonym: "neoxanthin cleavage enzyme" BROAD [] +synonym: "nine-cis-epoxycarotenoid dioxygenase activity" EXACT [EC:1.13.11.51] +synonym: "PvNCED1" RELATED [EC:1.13.11.51] +synonym: "VP14" RELATED [EC:1.13.11.51] +xref: EC:1.13.11.51 +is_a: GO:0010436 ! carotenoid dioxygenase activity + +[Term] +id: GO:0045550 +name: geranylgeranyl reductase activity +namespace: molecular_function +def: "Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety." [PMID:9492312] +subset: gosubset_prok +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0045551 +name: cinnamyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195] +synonym: "CAD activity" BROAD [EC:1.1.1.195] +synonym: "cinnamyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.195] +synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.195] +xref: EC:1.1.1.195 +xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045552 +name: dihydrokaempferol 4-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219] +subset: gosubset_prok +synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.219] +synonym: "dihydroflavanol 4-reductase activity" EXACT [EC:1.1.1.219] +synonym: "dihydroflavonol 4-reductase activity" EXACT [EC:1.1.1.219] +synonym: "dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] +synonym: "dihydroquercetin reductase activity" EXACT [EC:1.1.1.219] +synonym: "NADPH-dihydromyricetin reductase activity" EXACT [EC:1.1.1.219] +xref: EC:1.1.1.219 +xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045553 +name: TRAIL biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptosis in a wide variety of cells." [PMID:9311998] +synonym: "TRAIL anabolism" EXACT [] +synonym: "TRAIL biosynthesis" EXACT [] +synonym: "TRAIL formation" EXACT [] +synonym: "TRAIL synthesis" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032639 ! TRAIL production + +[Term] +id: GO:0045554 +name: regulation of TRAIL biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] +synonym: "regulation of TRAIL anabolism" EXACT [] +synonym: "regulation of TRAIL biosynthesis" EXACT [] +synonym: "regulation of TRAIL formation" EXACT [] +synonym: "regulation of TRAIL synthesis" EXACT [] +is_a: GO:0032679 ! regulation of TRAIL production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0045553 ! TRAIL biosynthetic process + +[Term] +id: GO:0045555 +name: negative regulation of TRAIL biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] +synonym: "down regulation of TRAIL biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL anabolism" EXACT [] +synonym: "negative regulation of TRAIL biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL formation" EXACT [] +synonym: "negative regulation of TRAIL synthesis" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0045554 ! regulation of TRAIL biosynthetic process +relationship: negatively_regulates GO:0045553 ! TRAIL biosynthetic process + +[Term] +id: GO:0045556 +name: positive regulation of TRAIL biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators] +synonym: "activation of TRAIL biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL anabolism" EXACT [] +synonym: "positive regulation of TRAIL biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL formation" EXACT [] +synonym: "positive regulation of TRAIL synthesis" EXACT [] +synonym: "stimulation of TRAIL biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0045554 ! regulation of TRAIL biosynthetic process +relationship: positively_regulates GO:0045553 ! TRAIL biosynthetic process + +[Term] +id: GO:0045557 +name: TRAIL receptor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +synonym: "TRAIL receptor anabolism" EXACT [] +synonym: "TRAIL receptor biosynthesis" EXACT [] +synonym: "TRAIL receptor formation" EXACT [] +synonym: "TRAIL receptor synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0045558 +name: TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998] +synonym: "TRAIL receptor 1 anabolism" EXACT [] +synonym: "TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "TRAIL receptor 1 formation" EXACT [] +synonym: "TRAIL receptor 1 synthesis" EXACT [] +is_a: GO:0045557 ! TRAIL receptor biosynthetic process + +[Term] +id: GO:0045559 +name: TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998] +synonym: "TRAIL receptor 2 anabolism" EXACT [] +synonym: "TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "TRAIL receptor 2 formation" EXACT [] +synonym: "TRAIL receptor 2 synthesis" EXACT [] +is_a: GO:0045557 ! TRAIL receptor biosynthetic process + +[Term] +id: GO:0045560 +name: regulation of TRAIL receptor biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +synonym: "regulation of TRAIL receptor anabolism" EXACT [] +synonym: "regulation of TRAIL receptor biosynthesis" EXACT [] +synonym: "regulation of TRAIL receptor formation" EXACT [] +synonym: "regulation of TRAIL receptor synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045557 ! TRAIL receptor biosynthetic process + +[Term] +id: GO:0045561 +name: regulation of TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] +synonym: "regulation of TRAIL receptor 1 anabolism" EXACT [] +synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "regulation of TRAIL receptor 1 formation" EXACT [] +synonym: "regulation of TRAIL receptor 1 synthesis" EXACT [] +is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process +relationship: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process + +[Term] +id: GO:0045562 +name: regulation of TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] +synonym: "regulation of TRAIL receptor 2 anabolism" EXACT [] +synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "regulation of TRAIL receptor 2 formation" EXACT [] +synonym: "regulation of TRAIL receptor 2 synthesis" EXACT [] +is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process +relationship: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process + +[Term] +id: GO:0045563 +name: negative regulation of TRAIL receptor biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL receptor anabolism" EXACT [] +synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL receptor formation" EXACT [] +synonym: "negative regulation of TRAIL receptor synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process +relationship: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process + +[Term] +id: GO:0045564 +name: positive regulation of TRAIL receptor biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +synonym: "activation of TRAIL receptor biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL receptor anabolism" EXACT [] +synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL receptor formation" EXACT [] +synonym: "positive regulation of TRAIL receptor synthesis" EXACT [] +synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process +relationship: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process + +[Term] +id: GO:0045565 +name: negative regulation of TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] +synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT [] +synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL receptor 1 formation" EXACT [] +synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT [] +is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process +is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process +relationship: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process + +[Term] +id: GO:0045566 +name: positive regulation of TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] +synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT [] +synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL receptor 1 formation" EXACT [] +synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT [] +synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT [] +is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process +is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process +relationship: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process + +[Term] +id: GO:0045567 +name: negative regulation of TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] +synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT [] +synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL receptor 2 formation" EXACT [] +synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT [] +is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process +is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process +relationship: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process + +[Term] +id: GO:0045568 +name: positive regulation of TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] +synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT [] +synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL receptor 2 formation" EXACT [] +synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT [] +synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT [] +is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process +is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process +relationship: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process + +[Term] +id: GO:0045569 +name: TRAIL binding +namespace: molecular_function +def: "Interacting selectively with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980] +synonym: "Apo-2L binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045570 +name: regulation of imaginal disc growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] +is_a: GO:0046620 ! regulation of organ growth +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007446 ! imaginal disc growth + +[Term] +id: GO:0045571 +name: negative regulation of imaginal disc growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] +synonym: "down regulation of imaginal disc growth" EXACT [] +synonym: "down-regulation of imaginal disc growth" EXACT [] +synonym: "downregulation of imaginal disc growth" EXACT [] +synonym: "inhibition of imaginal disc growth" NARROW [] +is_a: GO:0045570 ! regulation of imaginal disc growth +is_a: GO:0046621 ! negative regulation of organ growth +is_a: GO:0048640 ! negative regulation of developmental growth +relationship: negatively_regulates GO:0007446 ! imaginal disc growth + +[Term] +id: GO:0045572 +name: positive regulation of imaginal disc growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] +synonym: "activation of imaginal disc growth" NARROW [] +synonym: "stimulation of imaginal disc growth" NARROW [] +synonym: "up regulation of imaginal disc growth" EXACT [] +synonym: "up-regulation of imaginal disc growth" EXACT [] +synonym: "upregulation of imaginal disc growth" EXACT [] +is_a: GO:0045570 ! regulation of imaginal disc growth +is_a: GO:0046622 ! positive regulation of organ growth +is_a: GO:0048639 ! positive regulation of developmental growth +relationship: positively_regulates GO:0007446 ! imaginal disc growth + +[Term] +id: GO:0045574 +name: sterigmatocystin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "sterigmatocystin breakdown" EXACT [] +synonym: "sterigmatocystin catabolism" EXACT [] +synonym: "sterigmatocystin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0045460 ! sterigmatocystin metabolic process + +[Term] +id: GO:0045575 +name: basophil activation +namespace: biological_process +def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0045576 +name: mast cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0045577 +name: regulation of B cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators] +synonym: "regulation of B lymphocyte differentiation" EXACT [] +synonym: "regulation of B-cell differentiation" EXACT [] +synonym: "regulation of B-lymphocyte differentiation" EXACT [] +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0050864 ! regulation of B cell activation +relationship: regulates GO:0030183 ! B cell differentiation + +[Term] +id: GO:0045578 +name: negative regulation of B cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators] +synonym: "down regulation of B cell differentiation" EXACT [] +synonym: "down-regulation of B cell differentiation" EXACT [] +synonym: "downregulation of B cell differentiation" EXACT [] +synonym: "inhibition of B cell differentiation" NARROW [] +synonym: "negative regulation of B lymphocyte differentiation" EXACT [] +synonym: "negative regulation of B-cell differentiation" EXACT [] +synonym: "negative regulation of B-lymphocyte differentiation" EXACT [] +is_a: GO:0045577 ! regulation of B cell differentiation +is_a: GO:0045620 ! negative regulation of lymphocyte differentiation +is_a: GO:0050869 ! negative regulation of B cell activation +relationship: negatively_regulates GO:0030183 ! B cell differentiation + +[Term] +id: GO:0045579 +name: positive regulation of B cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators] +synonym: "activation of B cell differentiation" NARROW [] +synonym: "positive regulation of B lymphocyte differentiation" EXACT [] +synonym: "positive regulation of B-cell differentiation" EXACT [] +synonym: "positive regulation of B-lymphocyte differentiation" EXACT [] +synonym: "stimulation of B cell differentiation" NARROW [] +synonym: "up regulation of B cell differentiation" EXACT [] +synonym: "up-regulation of B cell differentiation" EXACT [] +synonym: "upregulation of B cell differentiation" EXACT [] +is_a: GO:0045577 ! regulation of B cell differentiation +is_a: GO:0045621 ! positive regulation of lymphocyte differentiation +is_a: GO:0050871 ! positive regulation of B cell activation +relationship: positively_regulates GO:0030183 ! B cell differentiation + +[Term] +id: GO:0045580 +name: regulation of T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators] +synonym: "regulation of T lymphocyte differentiation" EXACT [] +synonym: "regulation of T-cell differentiation" EXACT [] +synonym: "regulation of T-lymphocyte differentiation" EXACT [] +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045581 +name: negative regulation of T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators] +synonym: "down regulation of T cell differentiation" EXACT [] +synonym: "down-regulation of T cell differentiation" EXACT [] +synonym: "downregulation of T cell differentiation" EXACT [] +synonym: "inhibition of T cell differentiation" NARROW [] +synonym: "negative regulation of T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of T-cell differentiation" EXACT [] +synonym: "negative regulation of T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0045620 ! negative regulation of lymphocyte differentiation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045582 +name: positive regulation of T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators] +synonym: "activation of T cell differentiation" NARROW [] +synonym: "positive regulation of T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of T-cell differentiation" EXACT [] +synonym: "positive regulation of T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of T cell differentiation" NARROW [] +synonym: "up regulation of T cell differentiation" EXACT [] +synonym: "up-regulation of T cell differentiation" EXACT [] +synonym: "upregulation of T cell differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0045621 ! positive regulation of lymphocyte differentiation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045583 +name: regulation of cytotoxic T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] +synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "regulation of cytotoxic T-cell differentiation" EXACT [] +synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0045584 +name: negative regulation of cytotoxic T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] +synonym: "down regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "down-regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "downregulation of cytotoxic T cell differentiation" EXACT [] +synonym: "inhibition of cytotoxic T cell differentiation" NARROW [] +synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT [] +synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation +relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0045585 +name: positive regulation of cytotoxic T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] +synonym: "activation of cytotoxic T cell differentiation" NARROW [] +synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT [] +synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of cytotoxic T cell differentiation" NARROW [] +synonym: "up regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "up-regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "upregulation of cytotoxic T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation +relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0045586 +name: regulation of gamma-delta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] +synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "regulation of gamma-delta T-cell differentiation" EXACT [] +synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +relationship: regulates GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0045587 +name: negative regulation of gamma-delta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] +synonym: "down regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "down-regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "downregulation of gamma-delta T cell differentiation" EXACT [] +synonym: "inhibition of gamma-delta T cell differentiation" NARROW [] +synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT [] +synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation +is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation +relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0045588 +name: positive regulation of gamma-delta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] +synonym: "activation of gamma-delta T cell differentiation" NARROW [] +synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT [] +synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of gamma-delta T cell differentiation" NARROW [] +synonym: "up regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "up-regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "upregulation of gamma-delta T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation +is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation +relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0045589 +name: regulation of regulatory T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "regulation of regulatory T lymphocyte differentiation" EXACT [] +synonym: "regulation of regulatory T-cell differentiation" EXACT [] +synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT [] +synonym: "regulation of suppressor T cell differentiation" EXACT [] +synonym: "regulation of suppressor T lymphocyte differentiation" EXACT [] +synonym: "regulation of suppressor T-cell differentiation" EXACT [] +synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0045590 +name: negative regulation of regulatory T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of regulatory T cell differentiation" EXACT [] +synonym: "down-regulation of regulatory T cell differentiation" EXACT [] +synonym: "downregulation of regulatory T cell differentiation" EXACT [] +synonym: "inhibition of regulatory T cell differentiation" NARROW [] +synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of regulatory T-cell differentiation" EXACT [] +synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of suppressor T cell differentiation" EXACT [] +synonym: "negative regulation of suppressor T-cell differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0045589 ! regulation of regulatory T cell differentiation +relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0045591 +name: positive regulation of regulatory T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of regulatory T cell differentiation" NARROW [] +synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of regulatory T-cell differentiation" EXACT [] +synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of suppressor T cell differentiation" EXACT [] +synonym: "positive regulation of suppressor T-cell differentiation" EXACT [] +synonym: "stimulation of regulatory T cell differentiation" NARROW [] +synonym: "up regulation of regulatory T cell differentiation" EXACT [] +synonym: "up-regulation of regulatory T cell differentiation" EXACT [] +synonym: "upregulation of regulatory T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0045589 ! regulation of regulatory T cell differentiation +relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0045592 +name: regulation of cumulus cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] +synonym: "regulation of ovarian cumulus cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001549 ! cumulus cell differentiation + +[Term] +id: GO:0045593 +name: negative regulation of cumulus cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] +synonym: "down regulation of cumulus cell differentiation" EXACT [] +synonym: "down-regulation of cumulus cell differentiation" EXACT [] +synonym: "downregulation of cumulus cell differentiation" EXACT [] +synonym: "inhibition of cumulus cell differentiation" NARROW [] +synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT [] +is_a: GO:0045592 ! regulation of cumulus cell differentiation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation + +[Term] +id: GO:0045594 +name: positive regulation of cumulus cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] +synonym: "activation of cumulus cell differentiation" NARROW [] +synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT [] +synonym: "stimulation of cumulus cell differentiation" NARROW [] +synonym: "up regulation of cumulus cell differentiation" EXACT [] +synonym: "up-regulation of cumulus cell differentiation" EXACT [] +synonym: "upregulation of cumulus cell differentiation" EXACT [] +is_a: GO:0045592 ! regulation of cumulus cell differentiation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0001549 ! cumulus cell differentiation + +[Term] +id: GO:0045595 +name: regulation of cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0030154 ! cell differentiation + +[Term] +id: GO:0045596 +name: negative regulation of cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of cell differentiation" EXACT [] +synonym: "down-regulation of cell differentiation" EXACT [] +synonym: "downregulation of cell differentiation" EXACT [] +synonym: "inhibition of cell differentiation" NARROW [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0030154 ! cell differentiation + +[Term] +id: GO:0045597 +name: positive regulation of cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of cell differentiation" NARROW [] +synonym: "stimulation of cell differentiation" NARROW [] +synonym: "up regulation of cell differentiation" EXACT [] +synonym: "up-regulation of cell differentiation" EXACT [] +synonym: "upregulation of cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0030154 ! cell differentiation + +[Term] +id: GO:0045598 +name: regulation of fat cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] +synonym: "regulation of adipocyte cell differentiation" EXACT [] +synonym: "regulation of adipocyte differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0045599 +name: negative regulation of fat cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] +synonym: "down regulation of fat cell differentiation" EXACT [] +synonym: "down-regulation of fat cell differentiation" EXACT [] +synonym: "downregulation of fat cell differentiation" EXACT [] +synonym: "inhibition of fat cell differentiation" NARROW [] +synonym: "negative regulation of adipocyte cell differentiation" EXACT [] +synonym: "negative regulation of adipocyte differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045598 ! regulation of fat cell differentiation +relationship: negatively_regulates GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0045600 +name: positive regulation of fat cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] +synonym: "activation of fat cell differentiation" NARROW [] +synonym: "positive regulation of adipocyte cell differentiation" EXACT [] +synonym: "positive regulation of adipocyte differentiation" EXACT [] +synonym: "stimulation of fat cell differentiation" NARROW [] +synonym: "up regulation of fat cell differentiation" EXACT [] +synonym: "up-regulation of fat cell differentiation" EXACT [] +synonym: "upregulation of fat cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045598 ! regulation of fat cell differentiation +relationship: positively_regulates GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0045601 +name: regulation of endothelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0045602 +name: negative regulation of endothelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] +synonym: "down regulation of endothelial cell differentiation" EXACT [] +synonym: "down-regulation of endothelial cell differentiation" EXACT [] +synonym: "downregulation of endothelial cell differentiation" EXACT [] +synonym: "inhibition of endothelial cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045601 ! regulation of endothelial cell differentiation +relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0045603 +name: positive regulation of endothelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] +synonym: "activation of endothelial cell differentiation" NARROW [] +synonym: "stimulation of endothelial cell differentiation" NARROW [] +synonym: "up regulation of endothelial cell differentiation" EXACT [] +synonym: "up-regulation of endothelial cell differentiation" EXACT [] +synonym: "upregulation of endothelial cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045601 ! regulation of endothelial cell differentiation +relationship: positively_regulates GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0045604 +name: regulation of epidermal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0045682 ! regulation of epidermis development +relationship: regulates GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0045605 +name: negative regulation of epidermal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] +synonym: "down regulation of epidermal cell differentiation" EXACT [] +synonym: "down-regulation of epidermal cell differentiation" EXACT [] +synonym: "downregulation of epidermal cell differentiation" EXACT [] +synonym: "inhibition of epidermal cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045604 ! regulation of epidermal cell differentiation +is_a: GO:0045683 ! negative regulation of epidermis development +relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0045606 +name: positive regulation of epidermal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] +synonym: "activation of epidermal cell differentiation" NARROW [] +synonym: "stimulation of epidermal cell differentiation" NARROW [] +synonym: "up regulation of epidermal cell differentiation" EXACT [] +synonym: "up-regulation of epidermal cell differentiation" EXACT [] +synonym: "upregulation of epidermal cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045604 ! regulation of epidermal cell differentiation +is_a: GO:0045684 ! positive regulation of epidermis development +relationship: positively_regulates GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0045607 +name: regulation of auditory receptor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] +synonym: "regulation of auditory hair cell differentiation" EXACT [] +is_a: GO:0045631 ! regulation of mechanoreceptor differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042491 ! auditory receptor cell differentiation + +[Term] +id: GO:0045608 +name: negative regulation of auditory receptor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] +synonym: "down regulation of auditory receptor cell differentiation" EXACT [] +synonym: "down-regulation of auditory receptor cell differentiation" EXACT [] +synonym: "downregulation of auditory receptor cell differentiation" EXACT [] +synonym: "inhibition of auditory receptor cell differentiation" NARROW [] +synonym: "negative regulation of auditory hair cell differentiation" EXACT [] +is_a: GO:0045607 ! regulation of auditory receptor cell differentiation +is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation +relationship: negatively_regulates GO:0042491 ! auditory receptor cell differentiation + +[Term] +id: GO:0045609 +name: positive regulation of auditory receptor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] +synonym: "activation of auditory receptor cell differentiation" NARROW [] +synonym: "positive regulation of auditory hair cell differentiation" EXACT [] +synonym: "stimulation of auditory receptor cell differentiation" NARROW [] +synonym: "up regulation of auditory receptor cell differentiation" EXACT [] +synonym: "up-regulation of auditory receptor cell differentiation" EXACT [] +synonym: "upregulation of auditory receptor cell differentiation" EXACT [] +is_a: GO:0045607 ! regulation of auditory receptor cell differentiation +is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation +relationship: positively_regulates GO:0042491 ! auditory receptor cell differentiation + +[Term] +id: GO:0045610 +name: regulation of hemocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] +synonym: "regulation of arthropod blood cell differentiation" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0045611 +name: negative regulation of hemocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] +synonym: "down regulation of hemocyte differentiation" EXACT [] +synonym: "down-regulation of hemocyte differentiation" EXACT [] +synonym: "downregulation of hemocyte differentiation" EXACT [] +synonym: "inhibition of hemocyte differentiation" NARROW [] +synonym: "negative regulation of arthropod blood cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: negatively_regulates GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0045612 +name: positive regulation of hemocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] +synonym: "activation of hemocyte differentiation" NARROW [] +synonym: "positive regulation of arthropod blood cell differentiation" EXACT [] +synonym: "stimulation of hemocyte differentiation" NARROW [] +synonym: "up regulation of hemocyte differentiation" EXACT [] +synonym: "up-regulation of hemocyte differentiation" EXACT [] +synonym: "upregulation of hemocyte differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: positively_regulates GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0045613 +name: regulation of plasmatocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: regulates GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0045614 +name: negative regulation of plasmatocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] +synonym: "down regulation of plasmatocyte differentiation" EXACT [] +synonym: "down-regulation of plasmatocyte differentiation" EXACT [] +synonym: "downregulation of plasmatocyte differentiation" EXACT [] +synonym: "inhibition of plasmatocyte differentiation" NARROW [] +is_a: GO:0045611 ! negative regulation of hemocyte differentiation +is_a: GO:0045613 ! regulation of plasmatocyte differentiation +relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0045615 +name: positive regulation of plasmatocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] +synonym: "activation of plasmatocyte differentiation" NARROW [] +synonym: "stimulation of plasmatocyte differentiation" NARROW [] +synonym: "up regulation of plasmatocyte differentiation" EXACT [] +synonym: "up-regulation of plasmatocyte differentiation" EXACT [] +synonym: "upregulation of plasmatocyte differentiation" EXACT [] +is_a: GO:0045612 ! positive regulation of hemocyte differentiation +is_a: GO:0045613 ! regulation of plasmatocyte differentiation +relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0045616 +name: regulation of keratinocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0045617 +name: negative regulation of keratinocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] +synonym: "down regulation of keratinocyte differentiation" EXACT [] +synonym: "down-regulation of keratinocyte differentiation" EXACT [] +synonym: "downregulation of keratinocyte differentiation" EXACT [] +synonym: "inhibition of keratinocyte differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045616 ! regulation of keratinocyte differentiation +relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0045618 +name: positive regulation of keratinocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] +synonym: "activation of keratinocyte differentiation" NARROW [] +synonym: "stimulation of keratinocyte differentiation" NARROW [] +synonym: "up regulation of keratinocyte differentiation" EXACT [] +synonym: "up-regulation of keratinocyte differentiation" EXACT [] +synonym: "upregulation of keratinocyte differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045616 ! regulation of keratinocyte differentiation +relationship: positively_regulates GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0045619 +name: regulation of lymphocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0030098 ! lymphocyte differentiation + +[Term] +id: GO:0045620 +name: negative regulation of lymphocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] +synonym: "down regulation of lymphocyte differentiation" EXACT [] +synonym: "down-regulation of lymphocyte differentiation" EXACT [] +synonym: "downregulation of lymphocyte differentiation" EXACT [] +synonym: "inhibition of lymphocyte differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation + +[Term] +id: GO:0045621 +name: positive regulation of lymphocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] +synonym: "activation of lymphocyte differentiation" NARROW [] +synonym: "stimulation of lymphocyte differentiation" NARROW [] +synonym: "up regulation of lymphocyte differentiation" EXACT [] +synonym: "up-regulation of lymphocyte differentiation" EXACT [] +synonym: "upregulation of lymphocyte differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0030098 ! lymphocyte differentiation + +[Term] +id: GO:0045622 +name: regulation of T-helper cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] +is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0045623 +name: negative regulation of T-helper cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] +synonym: "down regulation of T-helper cell differentiation" EXACT [] +synonym: "down-regulation of T-helper cell differentiation" EXACT [] +synonym: "downregulation of T-helper cell differentiation" EXACT [] +synonym: "inhibition of T-helper cell differentiation" NARROW [] +is_a: GO:0043371 ! negative regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0045622 ! regulation of T-helper cell differentiation +relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0045624 +name: positive regulation of T-helper cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] +synonym: "activation of T-helper cell differentiation" NARROW [] +synonym: "stimulation of T-helper cell differentiation" NARROW [] +synonym: "up regulation of T-helper cell differentiation" EXACT [] +synonym: "up-regulation of T-helper cell differentiation" EXACT [] +synonym: "upregulation of T-helper cell differentiation" EXACT [] +is_a: GO:0043372 ! positive regulation of CD4-positive, alpha beta T cell differentiation +is_a: GO:0045622 ! regulation of T-helper cell differentiation +relationship: positively_regulates GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0045625 +name: regulation of T-helper 1 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +is_a: GO:0045622 ! regulation of T-helper cell differentiation +relationship: regulates GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0045626 +name: negative regulation of T-helper 1 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] +synonym: "down regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "down-regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "downregulation of T-helper 1 cell differentiation" EXACT [] +synonym: "inhibition of T-helper 1 cell differentiation" NARROW [] +is_a: GO:0045623 ! negative regulation of T-helper cell differentiation +is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation +relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0045627 +name: positive regulation of T-helper 1 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] +synonym: "activation of T-helper 1 cell differentiation" NARROW [] +synonym: "stimulation of T-helper 1 cell differentiation" NARROW [] +synonym: "up regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "up-regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "upregulation of T-helper 1 cell differentiation" EXACT [] +is_a: GO:0045624 ! positive regulation of T-helper cell differentiation +is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation +relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0045628 +name: regulation of T-helper 2 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] +is_a: GO:0002828 ! regulation of T-helper 2 type immune response +is_a: GO:0045622 ! regulation of T-helper cell differentiation +relationship: regulates GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0045629 +name: negative regulation of T-helper 2 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] +synonym: "down regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "down-regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "downregulation of T-helper 2 cell differentiation" EXACT [] +synonym: "inhibition of T-helper 2 cell differentiation" NARROW [] +is_a: GO:0045623 ! negative regulation of T-helper cell differentiation +is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation +relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0045630 +name: positive regulation of T-helper 2 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] +synonym: "activation of T-helper 2 cell differentiation" NARROW [] +synonym: "stimulation of T-helper 2 cell differentiation" NARROW [] +synonym: "up regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "up-regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "upregulation of T-helper 2 cell differentiation" EXACT [] +is_a: GO:0045624 ! positive regulation of T-helper cell differentiation +is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation +relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0045631 +name: regulation of mechanoreceptor differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0042490 ! mechanoreceptor differentiation + +[Term] +id: GO:0045632 +name: negative regulation of mechanoreceptor differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] +synonym: "down regulation of mechanoreceptor differentiation" EXACT [] +synonym: "down-regulation of mechanoreceptor differentiation" EXACT [] +synonym: "downregulation of mechanoreceptor differentiation" EXACT [] +synonym: "inhibition of mechanoreceptor differentiation" NARROW [] +is_a: GO:0045631 ! regulation of mechanoreceptor differentiation +is_a: GO:0045665 ! negative regulation of neuron differentiation +relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation + +[Term] +id: GO:0045633 +name: positive regulation of mechanoreceptor differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] +synonym: "activation of mechanoreceptor differentiation" NARROW [] +synonym: "stimulation of mechanoreceptor differentiation" NARROW [] +synonym: "up regulation of mechanoreceptor differentiation" EXACT [] +synonym: "up-regulation of mechanoreceptor differentiation" EXACT [] +synonym: "upregulation of mechanoreceptor differentiation" EXACT [] +is_a: GO:0045631 ! regulation of mechanoreceptor differentiation +is_a: GO:0045666 ! positive regulation of neuron differentiation +relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation + +[Term] +id: GO:0045634 +name: regulation of melanocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] +synonym: "regulation of melanophore differentiation" EXACT [] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0045635 +name: negative regulation of melanocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] +synonym: "down regulation of melanocyte differentiation" EXACT [] +synonym: "down-regulation of melanocyte differentiation" EXACT [] +synonym: "downregulation of melanocyte differentiation" EXACT [] +synonym: "inhibition of melanocyte differentiation" NARROW [] +synonym: "negative regulation of melanophore differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0045636 +name: positive regulation of melanocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] +synonym: "activation of melanocyte differentiation" NARROW [] +synonym: "positive regulation of melanophore differentiation" EXACT [] +synonym: "stimulation of melanocyte differentiation" NARROW [] +synonym: "up regulation of melanocyte differentiation" EXACT [] +synonym: "up-regulation of melanocyte differentiation" EXACT [] +synonym: "upregulation of melanocyte differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0045637 +name: regulation of myeloid cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0045638 +name: negative regulation of myeloid cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] +synonym: "down regulation of myeloid cell differentiation" EXACT [] +synonym: "down-regulation of myeloid cell differentiation" EXACT [] +synonym: "downregulation of myeloid cell differentiation" EXACT [] +synonym: "inhibition of myeloid cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0045639 +name: positive regulation of myeloid cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] +synonym: "activation of myeloid cell differentiation" NARROW [] +synonym: "stimulation of myeloid cell differentiation" NARROW [] +synonym: "up regulation of myeloid cell differentiation" EXACT [] +synonym: "up-regulation of myeloid cell differentiation" EXACT [] +synonym: "upregulation of myeloid cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: positively_regulates GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0045640 +name: regulation of basophil differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators] +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045641 +name: negative regulation of basophil differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators] +synonym: "down regulation of basophil differentiation" EXACT [] +synonym: "down-regulation of basophil differentiation" EXACT [] +synonym: "downregulation of basophil differentiation" EXACT [] +synonym: "inhibition of basophil differentiation" NARROW [] +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045640 ! regulation of basophil differentiation +relationship: negatively_regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045642 +name: positive regulation of basophil differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators] +synonym: "activation of basophil differentiation" NARROW [] +synonym: "stimulation of basophil differentiation" NARROW [] +synonym: "up regulation of basophil differentiation" EXACT [] +synonym: "up-regulation of basophil differentiation" EXACT [] +synonym: "upregulation of basophil differentiation" EXACT [] +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045640 ! regulation of basophil differentiation +relationship: positively_regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045643 +name: regulation of eosinophil differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: regulates GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0045644 +name: negative regulation of eosinophil differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] +synonym: "down regulation of eosinophil differentiation" EXACT [] +synonym: "down-regulation of eosinophil differentiation" EXACT [] +synonym: "downregulation of eosinophil differentiation" EXACT [] +synonym: "inhibition of eosinophil differentiation" NARROW [] +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045643 ! regulation of eosinophil differentiation +relationship: negatively_regulates GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0045645 +name: positive regulation of eosinophil differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] +synonym: "activation of eosinophil differentiation" NARROW [] +synonym: "stimulation of eosinophil differentiation" NARROW [] +synonym: "up regulation of eosinophil differentiation" EXACT [] +synonym: "up-regulation of eosinophil differentiation" EXACT [] +synonym: "upregulation of eosinophil differentiation" EXACT [] +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045643 ! regulation of eosinophil differentiation +relationship: positively_regulates GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0045646 +name: regulation of erythrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: regulates GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0045647 +name: negative regulation of erythrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] +synonym: "down regulation of erythrocyte differentiation" EXACT [] +synonym: "down-regulation of erythrocyte differentiation" EXACT [] +synonym: "downregulation of erythrocyte differentiation" EXACT [] +synonym: "inhibition of erythrocyte differentiation" NARROW [] +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0045648 +name: positive regulation of erythrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] +synonym: "activation of erythrocyte differentiation" NARROW [] +synonym: "stimulation of erythrocyte differentiation" NARROW [] +synonym: "up regulation of erythrocyte differentiation" EXACT [] +synonym: "up-regulation of erythrocyte differentiation" EXACT [] +synonym: "upregulation of erythrocyte differentiation" EXACT [] +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: positively_regulates GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0045649 +name: regulation of macrophage differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0045650 +name: negative regulation of macrophage differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] +synonym: "down regulation of macrophage differentiation" EXACT [] +synonym: "down-regulation of macrophage differentiation" EXACT [] +synonym: "downregulation of macrophage differentiation" EXACT [] +synonym: "inhibition of macrophage differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0045649 ! regulation of macrophage differentiation +relationship: negatively_regulates GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0045651 +name: positive regulation of macrophage differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] +synonym: "activation of macrophage differentiation" NARROW [] +synonym: "stimulation of macrophage differentiation" NARROW [] +synonym: "up regulation of macrophage differentiation" EXACT [] +synonym: "up-regulation of macrophage differentiation" EXACT [] +synonym: "upregulation of macrophage differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0045649 ! regulation of macrophage differentiation +relationship: positively_regulates GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0045652 +name: regulation of megakaryocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: regulates GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0045653 +name: negative regulation of megakaryocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] +synonym: "down regulation of megakaryocyte differentiation" EXACT [] +synonym: "down-regulation of megakaryocyte differentiation" EXACT [] +synonym: "downregulation of megakaryocyte differentiation" EXACT [] +synonym: "inhibition of megakaryocyte differentiation" NARROW [] +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +is_a: GO:0045652 ! regulation of megakaryocyte differentiation +relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0045654 +name: positive regulation of megakaryocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] +synonym: "activation of megakaryocyte differentiation" NARROW [] +synonym: "stimulation of megakaryocyte differentiation" NARROW [] +synonym: "up regulation of megakaryocyte differentiation" EXACT [] +synonym: "up-regulation of megakaryocyte differentiation" EXACT [] +synonym: "upregulation of megakaryocyte differentiation" EXACT [] +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +is_a: GO:0045652 ! regulation of megakaryocyte differentiation +relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0045655 +name: regulation of monocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030224 ! monocyte differentiation + +[Term] +id: GO:0045656 +name: negative regulation of monocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] +synonym: "down regulation of monocyte differentiation" EXACT [] +synonym: "down-regulation of monocyte differentiation" EXACT [] +synonym: "downregulation of monocyte differentiation" EXACT [] +synonym: "inhibition of monocyte differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0045655 ! regulation of monocyte differentiation +relationship: negatively_regulates GO:0030224 ! monocyte differentiation + +[Term] +id: GO:0045657 +name: positive regulation of monocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] +synonym: "activation of monocyte differentiation" NARROW [] +synonym: "stimulation of monocyte differentiation" NARROW [] +synonym: "up regulation of monocyte differentiation" EXACT [] +synonym: "up-regulation of monocyte differentiation" EXACT [] +synonym: "upregulation of monocyte differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0045655 ! regulation of monocyte differentiation +relationship: positively_regulates GO:0030224 ! monocyte differentiation + +[Term] +id: GO:0045658 +name: regulation of neutrophil differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: regulates GO:0030223 ! neutrophil differentiation + +[Term] +id: GO:0045659 +name: negative regulation of neutrophil differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] +synonym: "down regulation of neutrophil differentiation" EXACT [] +synonym: "down-regulation of neutrophil differentiation" EXACT [] +synonym: "downregulation of neutrophil differentiation" EXACT [] +synonym: "inhibition of neutrophil differentiation" NARROW [] +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045658 ! regulation of neutrophil differentiation +relationship: negatively_regulates GO:0030223 ! neutrophil differentiation + +[Term] +id: GO:0045660 +name: positive regulation of neutrophil differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] +synonym: "activation of neutrophil differentiation" NARROW [] +synonym: "stimulation of neutrophil differentiation" NARROW [] +synonym: "up regulation of neutrophil differentiation" EXACT [] +synonym: "up-regulation of neutrophil differentiation" EXACT [] +synonym: "upregulation of neutrophil differentiation" EXACT [] +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045658 ! regulation of neutrophil differentiation +relationship: positively_regulates GO:0030223 ! neutrophil differentiation + +[Term] +id: GO:0045661 +name: regulation of myoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +is_a: GO:0048742 ! regulation of skeletal muscle fiber development +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: regulates GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0045662 +name: negative regulation of myoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +synonym: "down regulation of myoblast differentiation" EXACT [] +synonym: "down-regulation of myoblast differentiation" EXACT [] +synonym: "downregulation of myoblast differentiation" EXACT [] +synonym: "inhibition of myoblast differentiation" NARROW [] +is_a: GO:0045661 ! regulation of myoblast differentiation +is_a: GO:0051148 ! negative regulation of muscle cell differentiation +relationship: negatively_regulates GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0045663 +name: positive regulation of myoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +synonym: "activation of myoblast differentiation" NARROW [] +synonym: "stimulation of myoblast differentiation" NARROW [] +synonym: "up regulation of myoblast differentiation" EXACT [] +synonym: "up-regulation of myoblast differentiation" EXACT [] +synonym: "upregulation of myoblast differentiation" EXACT [] +is_a: GO:0045661 ! regulation of myoblast differentiation +is_a: GO:0051149 ! positive regulation of muscle cell differentiation +relationship: positively_regulates GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0045664 +name: regulation of neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0050767 ! regulation of neurogenesis +relationship: regulates GO:0030182 ! neuron differentiation + +[Term] +id: GO:0045665 +name: negative regulation of neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] +synonym: "down regulation of neuron differentiation" EXACT [] +synonym: "down-regulation of neuron differentiation" EXACT [] +synonym: "downregulation of neuron differentiation" EXACT [] +synonym: "inhibition of neuron differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: negatively_regulates GO:0030182 ! neuron differentiation + +[Term] +id: GO:0045666 +name: positive regulation of neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] +synonym: "activation of neuron differentiation" NARROW [] +synonym: "stimulation of neuron differentiation" NARROW [] +synonym: "up regulation of neuron differentiation" EXACT [] +synonym: "up-regulation of neuron differentiation" EXACT [] +synonym: "upregulation of neuron differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: positively_regulates GO:0030182 ! neuron differentiation + +[Term] +id: GO:0045667 +name: regulation of osteoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] +is_a: GO:0030278 ! regulation of ossification +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0045668 +name: negative regulation of osteoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] +synonym: "down regulation of osteoblast differentiation" EXACT [] +synonym: "down-regulation of osteoblast differentiation" EXACT [] +synonym: "downregulation of osteoblast differentiation" EXACT [] +synonym: "inhibition of osteoblast differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045667 ! regulation of osteoblast differentiation +relationship: negatively_regulates GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0045669 +name: positive regulation of osteoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] +synonym: "activation of osteoblast differentiation" NARROW [] +synonym: "stimulation of osteoblast differentiation" NARROW [] +synonym: "up regulation of osteoblast differentiation" EXACT [] +synonym: "up-regulation of osteoblast differentiation" EXACT [] +synonym: "upregulation of osteoblast differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045667 ! regulation of osteoblast differentiation +relationship: positively_regulates GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0045670 +name: regulation of osteoclast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0045671 +name: negative regulation of osteoclast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] +synonym: "down regulation of osteoclast differentiation" EXACT [] +synonym: "down-regulation of osteoclast differentiation" EXACT [] +synonym: "downregulation of osteoclast differentiation" EXACT [] +synonym: "inhibition of osteoclast differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0045670 ! regulation of osteoclast differentiation +relationship: negatively_regulates GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0045672 +name: positive regulation of osteoclast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] +synonym: "activation of osteoclast differentiation" NARROW [] +synonym: "stimulation of osteoclast differentiation" NARROW [] +synonym: "up regulation of osteoclast differentiation" EXACT [] +synonym: "up-regulation of osteoclast differentiation" EXACT [] +synonym: "upregulation of osteoclast differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0045670 ! regulation of osteoclast differentiation +relationship: positively_regulates GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0045676 +name: regulation of R7 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045677 +name: negative regulation of R7 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of R7 differentiation" EXACT [] +synonym: "down-regulation of R7 differentiation" EXACT [] +synonym: "downregulation of R7 differentiation" EXACT [] +synonym: "inhibition of R7 differentiation" NARROW [] +synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0045676 ! regulation of R7 cell differentiation +is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation +relationship: negatively_regulates GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045678 +name: positive regulation of R7 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of R7 differentiation" NARROW [] +synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of R7 differentiation" NARROW [] +synonym: "up regulation of R7 differentiation" EXACT [] +synonym: "up-regulation of R7 differentiation" EXACT [] +synonym: "upregulation of R7 differentiation" EXACT [] +is_a: GO:0045676 ! regulation of R7 cell differentiation +is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation +relationship: positively_regulates GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045679 +name: regulation of R8 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045680 +name: negative regulation of R8 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of R8 differentiation" EXACT [] +synonym: "down-regulation of R8 differentiation" EXACT [] +synonym: "downregulation of R8 differentiation" EXACT [] +synonym: "inhibition of R8 differentiation" NARROW [] +synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0045679 ! regulation of R8 cell differentiation +is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation +relationship: negatively_regulates GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045681 +name: positive regulation of R8 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of R8 differentiation" NARROW [] +synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of R8 differentiation" NARROW [] +synonym: "up regulation of R8 differentiation" EXACT [] +synonym: "up-regulation of R8 differentiation" EXACT [] +synonym: "upregulation of R8 differentiation" EXACT [] +is_a: GO:0045679 ! regulation of R8 cell differentiation +is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation +relationship: positively_regulates GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045682 +name: regulation of epidermis development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] +synonym: "regulation of epidermal development" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0008544 ! epidermis development + +[Term] +id: GO:0045683 +name: negative regulation of epidermis development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] +synonym: "down regulation of epidermis development" EXACT [] +synonym: "down-regulation of epidermis development" EXACT [] +synonym: "downregulation of epidermis development" EXACT [] +synonym: "inhibition of epidermis development" NARROW [] +synonym: "negative regulation of epidermal development" EXACT [] +is_a: GO:0045682 ! regulation of epidermis development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0008544 ! epidermis development + +[Term] +id: GO:0045684 +name: positive regulation of epidermis development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] +synonym: "activation of epidermis development" NARROW [] +synonym: "positive regulation of epidermal development" EXACT [] +synonym: "stimulation of epidermis development" NARROW [] +synonym: "up regulation of epidermis development" EXACT [] +synonym: "up-regulation of epidermis development" EXACT [] +synonym: "upregulation of epidermis development" EXACT [] +is_a: GO:0045682 ! regulation of epidermis development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0008544 ! epidermis development + +[Term] +id: GO:0045685 +name: regulation of glial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] +synonym: "regulation of glia cell differentiation" EXACT [] +synonym: "regulation of neuroglia differentiation" EXACT [] +is_a: GO:0014013 ! regulation of gliogenesis +relationship: regulates GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0045686 +name: negative regulation of glial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] +synonym: "down regulation of glial cell differentiation" EXACT [] +synonym: "down-regulation of glial cell differentiation" EXACT [] +synonym: "downregulation of glial cell differentiation" EXACT [] +synonym: "inhibition of glial cell differentiation" NARROW [] +synonym: "negative regulation of glia cell differentiation" EXACT [] +synonym: "negative regulation of neuroglia differentiation" EXACT [] +is_a: GO:0014014 ! negative regulation of gliogenesis +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: negatively_regulates GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0045687 +name: positive regulation of glial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] +synonym: "activation of glial cell differentiation" NARROW [] +synonym: "positive regulation of glia cell differentiation" EXACT [] +synonym: "positive regulation of neuroglia differentiation" EXACT [] +synonym: "stimulation of glial cell differentiation" NARROW [] +synonym: "up regulation of glial cell differentiation" EXACT [] +synonym: "up-regulation of glial cell differentiation" EXACT [] +synonym: "upregulation of glial cell differentiation" EXACT [] +is_a: GO:0014015 ! positive regulation of gliogenesis +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: positively_regulates GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0045688 +name: regulation of antipodal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009557 ! antipodal cell differentiation + +[Term] +id: GO:0045689 +name: negative regulation of antipodal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "down regulation of antipodal cell differentiation" EXACT [] +synonym: "down-regulation of antipodal cell differentiation" EXACT [] +synonym: "downregulation of antipodal cell differentiation" EXACT [] +synonym: "inhibition of antipodal cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045688 ! regulation of antipodal cell differentiation +relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation + +[Term] +id: GO:0045690 +name: positive regulation of antipodal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "activation of antipodal cell differentiation" NARROW [] +synonym: "stimulation of antipodal cell differentiation" NARROW [] +synonym: "up regulation of antipodal cell differentiation" EXACT [] +synonym: "up-regulation of antipodal cell differentiation" EXACT [] +synonym: "upregulation of antipodal cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045688 ! regulation of antipodal cell differentiation +relationship: positively_regulates GO:0009557 ! antipodal cell differentiation + +[Term] +id: GO:0045691 +name: regulation of embryo sac central cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "regulation of female gametophyte central cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0045692 +name: negative regulation of embryo sac central cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "down regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "down-regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "downregulation of female gametophyte central cell differentiation" EXACT [] +synonym: "inhibition of female gametophyte central cell differentiation" NARROW [] +synonym: "negative regulation of female gametophyte central cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045691 ! regulation of embryo sac central cell differentiation +relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0045693 +name: positive regulation of embryo sac central cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "activation of female gametophyte central cell differentiation" NARROW [] +synonym: "positive regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "stimulation of female gametophyte central cell differentiation" NARROW [] +synonym: "up regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "up-regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "upregulation of female gametophyte central cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045691 ! regulation of embryo sac central cell differentiation +relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0045694 +name: regulation of embryo sac egg cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "regulation of female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009560 ! embryo sac egg cell differentiation + +[Term] +id: GO:0045695 +name: negative regulation of embryo sac egg cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "down regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "downregulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "inhibition of female gametophyte egg cell differentiation" NARROW [] +synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation +relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation + +[Term] +id: GO:0045696 +name: positive regulation of embryo sac egg cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "activation of female gametophyte egg cell differentiation" NARROW [] +synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "stimulation of female gametophyte egg cell differentiation" NARROW [] +synonym: "up regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "upregulation of female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation +relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation + +[Term] +id: GO:0045697 +name: regulation of synergid differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] +synonym: "regulation of synergid cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009563 ! synergid differentiation + +[Term] +id: GO:0045698 +name: negative regulation of synergid differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] +synonym: "down regulation of synergid differentiation" EXACT [] +synonym: "down-regulation of synergid differentiation" EXACT [] +synonym: "downregulation of synergid differentiation" EXACT [] +synonym: "inhibition of synergid differentiation" NARROW [] +synonym: "negative regulation of synergid cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045697 ! regulation of synergid differentiation +relationship: negatively_regulates GO:0009563 ! synergid differentiation + +[Term] +id: GO:0045699 +name: positive regulation of synergid differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] +synonym: "activation of synergid differentiation" NARROW [] +synonym: "positive regulation of synergid cell differentiation" EXACT [] +synonym: "stimulation of synergid differentiation" NARROW [] +synonym: "up regulation of synergid differentiation" EXACT [] +synonym: "up-regulation of synergid differentiation" EXACT [] +synonym: "upregulation of synergid differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045697 ! regulation of synergid differentiation +relationship: positively_regulates GO:0009563 ! synergid differentiation + +[Term] +id: GO:0045700 +name: regulation of spermatid nuclear differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045701 +name: negative regulation of spermatid nuclear differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] +synonym: "down regulation of spermatid nuclear differentiation" EXACT [] +synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] +synonym: "downregulation of spermatid nuclear differentiation" EXACT [] +synonym: "inhibition of spermatid nuclear differentiation" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045700 ! regulation of spermatid nuclear differentiation +relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045702 +name: positive regulation of spermatid nuclear differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] +synonym: "activation of spermatid nuclear differentiation" NARROW [] +synonym: "stimulation of spermatid nuclear differentiation" NARROW [] +synonym: "up regulation of spermatid nuclear differentiation" EXACT [] +synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] +synonym: "upregulation of spermatid nuclear differentiation" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045700 ! regulation of spermatid nuclear differentiation +relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045703 +name: ketoreductase activity +namespace: molecular_function +def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [EC:1.1.-.-] +xref: EC:1.1.-.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0045704 +name: regulation of salivary gland boundary specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] +synonym: "regulation of salivary gland determination" EXACT [GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0045705 +name: negative regulation of salivary gland boundary specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] +synonym: "down regulation of salivary gland determination" EXACT [] +synonym: "down-regulation of salivary gland determination" EXACT [] +synonym: "downregulation of salivary gland determination" EXACT [] +synonym: "inhibition of salivary gland determination" NARROW [] +synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0045706 +name: positive regulation of salivary gland boundary specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] +synonym: "activation of salivary gland determination" NARROW [] +synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb] +synonym: "stimulation of salivary gland determination" NARROW [] +synonym: "up regulation of salivary gland determination" EXACT [] +synonym: "up-regulation of salivary gland determination" EXACT [] +synonym: "upregulation of salivary gland determination" EXACT [] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0045707 +name: regulation of adult salivary gland boundary specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] +synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +relationship: regulates GO:0007434 ! adult salivary gland boundary specification + +[Term] +id: GO:0045708 +name: regulation of larval salivary gland boundary specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] +synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0007433 ! larval salivary gland boundary specification + +[Term] +id: GO:0045709 +name: negative regulation of adult salivary gland boundary specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] +synonym: "down regulation of adult salivary gland determination" EXACT [] +synonym: "down-regulation of adult salivary gland determination" EXACT [] +synonym: "downregulation of adult salivary gland determination" EXACT [] +synonym: "inhibition of adult salivary gland determination" NARROW [] +synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045705 ! negative regulation of salivary gland boundary specification +is_a: GO:0045707 ! regulation of adult salivary gland boundary specification +relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification + +[Term] +id: GO:0045710 +name: negative regulation of larval salivary gland boundary specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] +synonym: "down regulation of larval salivary gland determination" EXACT [] +synonym: "down-regulation of larval salivary gland determination" EXACT [] +synonym: "downregulation of larval salivary gland determination" EXACT [] +synonym: "inhibition of larval salivary gland determination" NARROW [] +synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045705 ! negative regulation of salivary gland boundary specification +is_a: GO:0045708 ! regulation of larval salivary gland boundary specification +relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification + +[Term] +id: GO:0045711 +name: positive regulation of adult salivary gland boundary specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] +synonym: "activation of adult salivary gland determination" NARROW [] +synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb] +synonym: "stimulation of adult salivary gland determination" NARROW [] +synonym: "up regulation of adult salivary gland determination" EXACT [] +synonym: "up-regulation of adult salivary gland determination" EXACT [] +synonym: "upregulation of adult salivary gland determination" EXACT [] +is_a: GO:0045706 ! positive regulation of salivary gland boundary specification +is_a: GO:0045707 ! regulation of adult salivary gland boundary specification +relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification + +[Term] +id: GO:0045712 +name: positive regulation of larval salivary gland boundary specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] +synonym: "activation of larval salivary gland determination" NARROW [] +synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb] +synonym: "stimulation of larval salivary gland determination" NARROW [] +synonym: "up regulation of larval salivary gland determination" EXACT [] +synonym: "up-regulation of larval salivary gland determination" EXACT [] +synonym: "upregulation of larval salivary gland determination" EXACT [] +is_a: GO:0045706 ! positive regulation of salivary gland boundary specification +is_a: GO:0045708 ! regulation of larval salivary gland boundary specification +relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification + +[Term] +id: GO:0045713 +name: low-density lipoprotein receptor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein by cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] +synonym: "LDLr biosynthesis" EXACT [] +synonym: "LDLr biosynthetic process" EXACT [] +synonym: "low-density lipoprotein receptor anabolism" EXACT [] +synonym: "low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "low-density lipoprotein receptor formation" EXACT [] +synonym: "low-density lipoprotein receptor synthesis" EXACT [] +is_a: GO:0032799 ! low-density lipoprotein receptor metabolic process +is_a: GO:0032800 ! receptor biosynthetic process + +[Term] +id: GO:0045714 +name: regulation of low-density lipoprotein receptor biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators] +synonym: "regulation of LDLr biosynthesis" EXACT [] +synonym: "regulation of LDLr biosynthetic process" EXACT [] +synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT [] +synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "regulation of low-density lipoprotein receptor formation" EXACT [] +synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045713 ! low-density lipoprotein receptor biosynthetic process + +[Term] +id: GO:0045715 +name: negative regulation of low-density lipoprotein receptor biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators] +synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW [] +synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045714 ! regulation of low-density lipoprotein receptor biosynthetic process +relationship: negatively_regulates GO:0045713 ! low-density lipoprotein receptor biosynthetic process + +[Term] +id: GO:0045716 +name: positive regulation of low-density lipoprotein receptor biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators] +synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW [] +synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT [] +synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW [] +synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045714 ! regulation of low-density lipoprotein receptor biosynthetic process +relationship: positively_regulates GO:0045713 ! low-density lipoprotein receptor biosynthetic process + +[Term] +id: GO:0045717 +name: negative regulation of fatty acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of fatty acid biosynthetic process" EXACT [] +synonym: "down-regulation of fatty acid biosynthetic process" EXACT [] +synonym: "downregulation of fatty acid biosynthetic process" EXACT [] +synonym: "inhibition of fatty acid biosynthetic process" NARROW [] +synonym: "negative regulation of fatty acid anabolism" EXACT [] +synonym: "negative regulation of fatty acid biosynthesis" EXACT [] +synonym: "negative regulation of fatty acid formation" EXACT [] +synonym: "negative regulation of fatty acid synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0045718 +name: negative regulation of flagellum biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] +synonym: "down regulation of flagellum biogenesis" EXACT [] +synonym: "down-regulation of flagellum biogenesis" EXACT [] +synonym: "downregulation of flagellum biogenesis" EXACT [] +synonym: "inhibition of flagellum biogenesis" NARROW [] +synonym: "negative regulation of flagella biogenesis" EXACT [] +is_a: GO:0030092 ! regulation of flagellum biogenesis +is_a: GO:0031345 ! negative regulation of cell projection organization +relationship: negatively_regulates GO:0009296 ! flagellum biogenesis + +[Term] +id: GO:0045719 +name: negative regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of glycogen biosynthetic process" EXACT [] +synonym: "down-regulation of glycogen biosynthetic process" EXACT [] +synonym: "downregulation of glycogen biosynthetic process" EXACT [] +synonym: "inhibition of glycogen biosynthetic process" NARROW [] +synonym: "negative regulation of glycogen anabolism" EXACT [] +synonym: "negative regulation of glycogen biosynthesis" EXACT [] +synonym: "negative regulation of glycogen formation" EXACT [] +synonym: "negative regulation of glycogen synthesis" EXACT [] +is_a: GO:0005979 ! regulation of glycogen biosynthetic process +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process + +[Term] +id: GO:0045720 +name: negative regulation of integrin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] +synonym: "down regulation of integrin biosynthetic process" EXACT [] +synonym: "down-regulation of integrin biosynthetic process" EXACT [] +synonym: "downregulation of integrin biosynthetic process" EXACT [] +synonym: "inhibition of integrin biosynthetic process" NARROW [] +synonym: "negative regulation of integrin anabolism" EXACT [] +synonym: "negative regulation of integrin biosynthesis" EXACT [] +synonym: "negative regulation of integrin formation" EXACT [] +synonym: "negative regulation of integrin synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045113 ! regulation of integrin biosynthetic process +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045721 +name: negative regulation of gluconeogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of gluconeogenesis" EXACT [] +synonym: "down-regulation of gluconeogenesis" EXACT [] +synonym: "downregulation of gluconeogenesis" EXACT [] +synonym: "inhibition of gluconeogenesis" NARROW [] +is_a: GO:0006111 ! regulation of gluconeogenesis +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0006094 ! gluconeogenesis + +[Term] +id: GO:0045722 +name: positive regulation of gluconeogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of gluconeogenesis" NARROW [] +synonym: "stimulation of gluconeogenesis" NARROW [] +synonym: "up regulation of gluconeogenesis" EXACT [] +synonym: "up-regulation of gluconeogenesis" EXACT [] +synonym: "upregulation of gluconeogenesis" EXACT [] +is_a: GO:0006111 ! regulation of gluconeogenesis +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0006094 ! gluconeogenesis + +[Term] +id: GO:0045723 +name: positive regulation of fatty acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of fatty acid biosynthetic process" NARROW [] +synonym: "positive regulation of fatty acid anabolism" EXACT [] +synonym: "positive regulation of fatty acid biosynthesis" EXACT [] +synonym: "positive regulation of fatty acid formation" EXACT [] +synonym: "positive regulation of fatty acid synthesis" EXACT [] +synonym: "stimulation of fatty acid biosynthetic process" NARROW [] +synonym: "up regulation of fatty acid biosynthetic process" EXACT [] +synonym: "up-regulation of fatty acid biosynthetic process" EXACT [] +synonym: "upregulation of fatty acid biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0045724 +name: positive regulation of flagellum biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] +synonym: "activation of flagellum biogenesis" NARROW [] +synonym: "positive regulation of flagella biogenesis" EXACT [] +synonym: "stimulation of flagellum biogenesis" NARROW [] +synonym: "up regulation of flagellum biogenesis" EXACT [] +synonym: "up-regulation of flagellum biogenesis" EXACT [] +synonym: "upregulation of flagellum biogenesis" EXACT [] +is_a: GO:0030092 ! regulation of flagellum biogenesis +is_a: GO:0031346 ! positive regulation of cell projection organization +relationship: positively_regulates GO:0009296 ! flagellum biogenesis + +[Term] +id: GO:0045725 +name: positive regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of glycogen biosynthetic process" NARROW [] +synonym: "positive regulation of glycogen anabolism" EXACT [] +synonym: "positive regulation of glycogen biosynthesis" EXACT [] +synonym: "positive regulation of glycogen formation" EXACT [] +synonym: "positive regulation of glycogen synthesis" EXACT [] +synonym: "stimulation of glycogen biosynthetic process" NARROW [] +synonym: "up regulation of glycogen biosynthetic process" EXACT [] +synonym: "up-regulation of glycogen biosynthetic process" EXACT [] +synonym: "upregulation of glycogen biosynthetic process" EXACT [] +is_a: GO:0005979 ! regulation of glycogen biosynthetic process +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process + +[Term] +id: GO:0045726 +name: positive regulation of integrin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] +synonym: "activation of integrin biosynthetic process" NARROW [] +synonym: "positive regulation of integrin anabolism" EXACT [] +synonym: "positive regulation of integrin biosynthesis" EXACT [] +synonym: "positive regulation of integrin formation" EXACT [] +synonym: "positive regulation of integrin synthesis" EXACT [] +synonym: "stimulation of integrin biosynthetic process" NARROW [] +synonym: "up regulation of integrin biosynthetic process" EXACT [] +synonym: "up-regulation of integrin biosynthetic process" EXACT [] +synonym: "upregulation of integrin biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045113 ! regulation of integrin biosynthetic process +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045727 +name: positive regulation of translation +namespace: biological_process +alt_id: GO:0045946 +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb] +subset: gosubset_prok +synonym: "activation of protein biosynthetic process" NARROW [] +synonym: "positive regulation of protein anabolism" EXACT [] +synonym: "positive regulation of protein biosynthesis" EXACT [] +synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] +synonym: "positive regulation of protein formation" EXACT [] +synonym: "positive regulation of protein synthesis" EXACT [] +synonym: "stimulation of protein biosynthetic process" NARROW [] +synonym: "up regulation of protein biosynthetic process" EXACT [] +synonym: "up-regulation of protein biosynthetic process" EXACT [] +synonym: "upregulation of protein biosynthetic process" EXACT [] +xref: Reactome:110506 +is_a: GO:0006417 ! regulation of translation +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +relationship: positively_regulates GO:0006412 ! translation + +[Term] +id: GO:0045728 +name: respiratory burst after phagocytosis +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "metabolic burst after phagocytosis" EXACT [] +synonym: "oxidative burst after phagocytosis" EXACT [] +is_a: GO:0002679 ! respiratory burst during defense response + +[Term] +id: GO:0045729 +name: respiratory burst at fertilization +namespace: biological_process +def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:2537493, PMID:9013127] +synonym: "metabolic burst at fertilization" EXACT [] +synonym: "oxidative burst at fertilization" EXACT [] +is_a: GO:0045730 ! respiratory burst +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0045730 +name: respiratory burst +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "metabolic burst" EXACT [] +synonym: "oxidative burst" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0045732 +name: positive regulation of protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of protein catabolic process" NARROW [] +synonym: "positive regulation of protein breakdown" EXACT [] +synonym: "positive regulation of protein catabolism" EXACT [] +synonym: "positive regulation of protein degradation" EXACT [] +synonym: "stimulation of protein catabolic process" NARROW [] +synonym: "up regulation of protein catabolic process" EXACT [] +synonym: "up-regulation of protein catabolic process" EXACT [] +synonym: "upregulation of protein catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0030163 ! protein catabolic process + +[Term] +id: GO:0045733 +name: acetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "acetate breakdown" EXACT [] +synonym: "acetate catabolism" EXACT [] +synonym: "acetate degradation" EXACT [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0045734 +name: regulation of acetate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of acetate breakdown" EXACT [] +synonym: "regulation of acetate catabolism" EXACT [] +synonym: "regulation of acetate degradation" EXACT [] +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045735 +name: nutrient reservoir activity +namespace: molecular_function +def: "Functions in the storage of nutritious substrates." [GOC:ai] +comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'. +subset: goslim_generic +subset: goslim_pir +subset: gosubset_prok +synonym: "storage protein" RELATED [] +synonym: "storage protein of fat body (sensu Insecta)" RELATED [] +synonym: "yolk protein" RELATED [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0045736 +name: negative regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity." [GOC:go_curators] +synonym: "CDK inhibitor" RELATED [] +synonym: "cyclin-dependent kinase inhibitor" RELATED [] +synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW [] +synonym: "negative regulation of CDK activity" EXACT [] +is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0045786 ! negative regulation of cell cycle + +[Term] +id: GO:0045737 +name: positive regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators] +synonym: "activation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "positive regulation of CDK activity" EXACT [] +synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [] +is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity +is_a: GO:0045787 ! positive regulation of cell cycle +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0045738 +name: negative regulation of DNA repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of DNA repair" EXACT [] +synonym: "down-regulation of DNA repair" EXACT [] +synonym: "downregulation of DNA repair" EXACT [] +synonym: "inhibition of DNA repair" NARROW [] +is_a: GO:0006282 ! regulation of DNA repair +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0045739 +name: positive regulation of DNA repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of DNA repair" NARROW [] +synonym: "stimulation of DNA repair" NARROW [] +synonym: "up regulation of DNA repair" EXACT [] +synonym: "up-regulation of DNA repair" EXACT [] +synonym: "upregulation of DNA repair" EXACT [] +is_a: GO:0006282 ! regulation of DNA repair +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0045740 +name: positive regulation of DNA replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of DNA replication" NARROW [] +synonym: "stimulation of DNA replication" NARROW [] +synonym: "up regulation of DNA replication" EXACT [] +synonym: "up-regulation of DNA replication" EXACT [] +synonym: "upregulation of DNA replication" EXACT [] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0006260 ! DNA replication + +[Term] +id: GO:0045741 +name: positive regulation of epidermal growth factor receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor activity." [GOC:go_curators] +synonym: "activation of epidermal growth factor receptor activity" NARROW [] +synonym: "positive regulation of EGF receptor activity" EXACT [] +synonym: "positive regulation of EGFR activity" EXACT [] +synonym: "stimulation of epidermal growth factor receptor activity" NARROW [] +synonym: "up regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "up-regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "upregulation of epidermal growth factor receptor activity" EXACT [] +is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity +is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0045742 +name: positive regulation of epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of EGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of EGF receptor signalling pathway" EXACT [] +synonym: "positive regulation of EGFR signaling pathway" EXACT [] +synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway +relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0045743 +name: positive regulation of fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of FGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of FGF receptor signalling pathway" EXACT [] +synonym: "positive regulation of FGFR signaling pathway" EXACT [] +synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway +relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway + +[Term] +id: GO:0045744 +name: negative regulation of G-protein coupled receptor protein signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] +synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] +synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "negative regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] +synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] +synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0045745 +name: positive regulation of G-protein coupled receptor protein signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] +synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] +synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] +synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] +synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] +synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] +synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0045746 +name: negative regulation of Notch signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] +synonym: "down regulation of Notch signaling pathway" EXACT [] +synonym: "down-regulation of Notch signaling pathway" EXACT [] +synonym: "downregulation of Notch signaling pathway" EXACT [] +synonym: "inhibition of Notch signaling pathway" NARROW [] +synonym: "negative regulation of N signaling pathway" EXACT [] +synonym: "negative regulation of N signalling pathway" EXACT [] +synonym: "negative regulation of Notch signalling pathway" EXACT [] +is_a: GO:0008593 ! regulation of Notch signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0045747 +name: positive regulation of Notch signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] +synonym: "activation of Notch signaling pathway" NARROW [] +synonym: "positive regulation of N signaling pathway" EXACT [] +synonym: "positive regulation of N signalling pathway" EXACT [] +synonym: "positive regulation of Notch signalling pathway" EXACT [] +synonym: "stimulation of Notch signaling pathway" NARROW [] +synonym: "up regulation of Notch signaling pathway" EXACT [] +synonym: "up-regulation of Notch signaling pathway" EXACT [] +synonym: "upregulation of Notch signaling pathway" EXACT [] +is_a: GO:0008593 ! regulation of Notch signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0045748 +name: positive regulation of R8 cell spacing in compound eye +namespace: biological_process +def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of R8 spacing" NARROW [] +synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of R8 spacing" NARROW [] +synonym: "up regulation of R8 spacing" EXACT [] +synonym: "up-regulation of R8 spacing" EXACT [] +synonym: "upregulation of R8 spacing" EXACT [] +is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye + +[Term] +id: GO:0045749 +name: negative regulation of S phase of mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] +synonym: "down regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "down-regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "downregulation of S phase of mitotic cell cycle" EXACT [] +synonym: "inhibition of S phase of mitotic cell cycle" NARROW [] +is_a: GO:0007090 ! regulation of S phase of mitotic cell cycle +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +relationship: negatively_regulates GO:0000084 ! S phase of mitotic cell cycle + +[Term] +id: GO:0045750 +name: positive regulation of S phase of mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] +synonym: "activation of S phase of mitotic cell cycle" NARROW [] +synonym: "stimulation of S phase of mitotic cell cycle" NARROW [] +synonym: "up regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "up-regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "upregulation of S phase of mitotic cell cycle" EXACT [] +is_a: GO:0007090 ! regulation of S phase of mitotic cell cycle +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +relationship: positively_regulates GO:0000084 ! S phase of mitotic cell cycle + +[Term] +id: GO:0045751 +name: negative regulation of Toll signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] +synonym: "down regulation of Toll signaling pathway" EXACT [] +synonym: "down-regulation of Toll signaling pathway" EXACT [] +synonym: "downregulation of Toll signaling pathway" EXACT [] +synonym: "inhibition of Toll signaling pathway" NARROW [] +synonym: "negative regulation of Tl signaling pathway" EXACT [] +synonym: "negative regulation of Tl signalling pathway" EXACT [] +is_a: GO:0008592 ! regulation of Toll signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0008063 ! Toll signaling pathway + +[Term] +id: GO:0045752 +name: positive regulation of Toll signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] +synonym: "activation of Toll signaling pathway" NARROW [] +synonym: "positive regulation of Tl signaling pathway" EXACT [] +synonym: "positive regulation of Tl signalling pathway" EXACT [] +synonym: "stimulation of Toll signaling pathway" NARROW [] +synonym: "up regulation of Toll signaling pathway" EXACT [] +synonym: "up-regulation of Toll signaling pathway" EXACT [] +synonym: "upregulation of Toll signaling pathway" EXACT [] +is_a: GO:0008592 ! regulation of Toll signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0008063 ! Toll signaling pathway + +[Term] +id: GO:0045753 +name: negative regulation of acetate catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of acetate catabolic process" EXACT [] +synonym: "down-regulation of acetate catabolic process" EXACT [] +synonym: "downregulation of acetate catabolic process" EXACT [] +synonym: "inhibition of acetate catabolic process" NARROW [] +synonym: "negative regulation of acetate breakdown" EXACT [] +synonym: "negative regulation of acetate catabolism" EXACT [] +synonym: "negative regulation of acetate degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045734 ! regulation of acetate catabolic process +relationship: negatively_regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045754 +name: positive regulation of acetate catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of acetate catabolic process" NARROW [] +synonym: "positive regulation of acetate breakdown" EXACT [] +synonym: "positive regulation of acetate catabolism" EXACT [] +synonym: "positive regulation of acetate degradation" EXACT [] +synonym: "stimulation of acetate catabolic process" NARROW [] +synonym: "up regulation of acetate catabolic process" EXACT [] +synonym: "up-regulation of acetate catabolic process" EXACT [] +synonym: "upregulation of acetate catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045734 ! regulation of acetate catabolic process +relationship: positively_regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045755 +name: negative regulation of initiation of acetate catabolic process by acetate +namespace: biological_process +def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW [] +synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT [] +synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT [] +is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate + +[Term] +id: GO:0045756 +name: positive regulation of initiation of acetate catabolic process by acetate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of initiation of acetate catabolic process by acetate" NARROW [] +synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT [] +synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT [] +synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW [] +synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT [] +is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate + +[Term] +id: GO:0045757 +name: negative regulation of actin polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +is_obsolete: true +consider: GO:0030835 +consider: GO:0030837 + +[Term] +id: GO:0045758 +name: positive regulation of actin polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +is_obsolete: true +consider: GO:0030836 +consider: GO:0030838 + +[Term] +id: GO:0045759 +name: negative regulation of action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:go_curators] +synonym: "down regulation of action potential" EXACT [] +synonym: "down-regulation of action potential" EXACT [] +synonym: "downregulation of action potential" EXACT [] +synonym: "inhibition of action potential" NARROW [] +is_a: GO:0001508 ! regulation of action potential + +[Term] +id: GO:0045760 +name: positive regulation of action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:go_curators] +synonym: "activation of action potential" NARROW [] +synonym: "stimulation of action potential" NARROW [] +synonym: "up regulation of action potential" EXACT [] +synonym: "up-regulation of action potential" EXACT [] +synonym: "upregulation of action potential" EXACT [] +is_a: GO:0001508 ! regulation of action potential + +[Term] +id: GO:0045761 +name: regulation of adenylate cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] +synonym: "adenylate cyclase regulator" RELATED [] +synonym: "regulation of adenylyl cyclase activity" EXACT [] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0045762 +name: positive regulation of adenylate cyclase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] +synonym: "adenylate cyclase activator" RELATED [] +synonym: "positive regulation of adenylyl cyclase activity" EXACT [] +synonym: "stimulation of adenylate cyclase activity" NARROW [] +synonym: "up regulation of adenylate cyclase activity" EXACT [] +synonym: "up-regulation of adenylate cyclase activity" EXACT [] +synonym: "upregulation of adenylate cyclase activity" EXACT [] +is_a: GO:0031281 ! positive regulation of cyclase activity +is_a: GO:0045761 ! regulation of adenylate cyclase activity +is_a: GO:0051349 ! positive regulation of lyase activity + +[Term] +id: GO:0045763 +name: negative regulation of amino acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of amino acid metabolic process" EXACT [] +synonym: "down-regulation of amino acid metabolic process" EXACT [] +synonym: "downregulation of amino acid metabolic process" EXACT [] +synonym: "inhibition of amino acid metabolic process" NARROW [] +synonym: "negative regulation of amino acid metabolism" EXACT [] +is_a: GO:0006521 ! regulation of amino acid metabolic process +is_a: GO:0033239 ! negative regulation of amine metabolic process +relationship: negatively_regulates GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0045764 +name: positive regulation of amino acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of amino acid metabolic process" NARROW [] +synonym: "positive regulation of amino acid metabolism" EXACT [] +synonym: "stimulation of amino acid metabolic process" NARROW [] +synonym: "up regulation of amino acid metabolic process" EXACT [] +synonym: "up-regulation of amino acid metabolic process" EXACT [] +synonym: "upregulation of amino acid metabolic process" EXACT [] +is_a: GO:0006521 ! regulation of amino acid metabolic process +is_a: GO:0033240 ! positive regulation of amine metabolic process +relationship: positively_regulates GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0045765 +name: regulation of angiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001525 ! angiogenesis + +[Term] +id: GO:0045766 +name: positive regulation of angiogenesis +namespace: biological_process +def: "Any process that activates or increases angiogenesis." [GOC:go_curators] +synonym: "activation of angiogenesis" NARROW [] +synonym: "stimulation of angiogenesis" NARROW [] +synonym: "up regulation of angiogenesis" EXACT [] +synonym: "up-regulation of angiogenesis" EXACT [] +synonym: "upregulation of angiogenesis" EXACT [] +is_a: GO:0045765 ! regulation of angiogenesis +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0001525 ! angiogenesis + +[Term] +id: GO:0045767 +name: regulation of anti-apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0006916 ! anti-apoptosis + +[Term] +id: GO:0045768 +name: positive regulation of anti-apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators] +synonym: "activation of anti-apoptosis" NARROW [] +synonym: "stimulation of anti-apoptosis" NARROW [] +synonym: "up regulation of anti-apoptosis" EXACT [] +synonym: "up-regulation of anti-apoptosis" EXACT [] +synonym: "upregulation of anti-apoptosis" EXACT [] +is_a: GO:0045767 ! regulation of anti-apoptosis +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0006916 ! anti-apoptosis + +[Term] +id: GO:0045769 +name: negative regulation of asymmetric cell division +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] +synonym: "down regulation of asymmetric cell division" EXACT [] +synonym: "down-regulation of asymmetric cell division" EXACT [] +synonym: "downregulation of asymmetric cell division" EXACT [] +synonym: "inhibition of asymmetric cell division" NARROW [] +is_a: GO:0009786 ! regulation of asymmetric cell division +is_a: GO:0051782 ! negative regulation of cell division +relationship: negatively_regulates GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0045770 +name: positive regulation of asymmetric cell division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] +synonym: "activation of asymmetric cell division" NARROW [] +synonym: "stimulation of asymmetric cell division" NARROW [] +synonym: "up regulation of asymmetric cell division" EXACT [] +synonym: "up-regulation of asymmetric cell division" EXACT [] +synonym: "upregulation of asymmetric cell division" EXACT [] +is_a: GO:0009786 ! regulation of asymmetric cell division +is_a: GO:0051781 ! positive regulation of cell division +relationship: positively_regulates GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0045771 +name: negative regulation of autophagic vacuole size +namespace: biological_process +def: "Any process that reduces autophagic vacuole size." [GOC:go_curators] +synonym: "down regulation of autophagic vacuole size" EXACT [] +synonym: "down-regulation of autophagic vacuole size" EXACT [] +synonym: "downregulation of autophagic vacuole size" EXACT [] +synonym: "inhibition of autophagic vacuole size" NARROW [] +is_a: GO:0016243 ! regulation of autophagic vacuole size + +[Term] +id: GO:0045772 +name: positive regulation of autophagic vacuole size +namespace: biological_process +def: "Any process that increases autophagic vacuole size." [GOC:go_curators] +synonym: "activation of autophagic vacuole size" NARROW [] +synonym: "stimulation of autophagic vacuole size" NARROW [] +synonym: "up regulation of autophagic vacuole size" EXACT [] +synonym: "up-regulation of autophagic vacuole size" EXACT [] +synonym: "upregulation of autophagic vacuole size" EXACT [] +is_a: GO:0016243 ! regulation of autophagic vacuole size + +[Term] +id: GO:0045773 +name: positive regulation of axon extension +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators] +synonym: "activation of axon extension" NARROW [] +synonym: "stimulation of axon extension" NARROW [] +synonym: "up regulation of axon extension" EXACT [] +synonym: "up-regulation of axon extension" EXACT [] +synonym: "upregulation of axon extension" EXACT [] +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0050772 ! positive regulation of axonogenesis +relationship: positively_regulates GO:0048675 ! axon extension + +[Term] +id: GO:0045774 +name: negative regulation of beta 2 integrin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] +synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW [] +synonym: "negative regulation of beta 2 integrin anabolism" EXACT [] +synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT [] +synonym: "negative regulation of beta 2 integrin formation" EXACT [] +synonym: "negative regulation of beta 2 integrin synthesis" EXACT [] +is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process +is_a: GO:0045720 ! negative regulation of integrin biosynthetic process +relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process + +[Term] +id: GO:0045775 +name: positive regulation of beta 2 integrin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] +synonym: "activation of beta 2 integrin biosynthetic process" NARROW [] +synonym: "positive regulation of beta 2 integrin anabolism" EXACT [] +synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT [] +synonym: "positive regulation of beta 2 integrin formation" EXACT [] +synonym: "positive regulation of beta 2 integrin synthesis" EXACT [] +synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW [] +synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT [] +is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process +is_a: GO:0045726 ! positive regulation of integrin biosynthetic process +relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process + +[Term] +id: GO:0045776 +name: negative regulation of blood pressure +namespace: biological_process +def: "The process by which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio] +synonym: "down regulation of blood pressure" EXACT [] +synonym: "down-regulation of blood pressure" EXACT [] +synonym: "downregulation of blood pressure" EXACT [] +synonym: "inhibition of blood pressure" NARROW [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0045777 +name: positive regulation of blood pressure +namespace: biological_process +def: "The process by which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio] +synonym: "activation of blood pressure" NARROW [] +synonym: "stimulation of blood pressure" NARROW [] +synonym: "up regulation of blood pressure" EXACT [] +synonym: "up-regulation of blood pressure" EXACT [] +synonym: "upregulation of blood pressure" EXACT [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0045778 +name: positive regulation of ossification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone formation." [GOC:go_curators] +synonym: "activation of ossification" NARROW [] +synonym: "positive regulation of bone biosynthesis" EXACT [] +synonym: "positive regulation of bone formation" EXACT [] +synonym: "stimulation of ossification" NARROW [] +synonym: "up regulation of ossification" EXACT [] +synonym: "up-regulation of ossification" EXACT [] +synonym: "upregulation of ossification" EXACT [] +is_a: GO:0030278 ! regulation of ossification +is_a: GO:0046852 ! positive regulation of bone remodeling +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0001503 ! ossification + +[Term] +id: GO:0045779 +name: negative regulation of bone resorption +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators] +synonym: "down regulation of bone resorption" EXACT [] +synonym: "down-regulation of bone resorption" EXACT [] +synonym: "downregulation of bone resorption" EXACT [] +synonym: "inhibition of bone resorption" NARROW [] +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0045124 ! regulation of bone resorption +is_a: GO:0046851 ! negative regulation of bone remodeling +relationship: negatively_regulates GO:0045453 ! bone resorption + +[Term] +id: GO:0045780 +name: positive regulation of bone resorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators] +synonym: "activation of bone resorption" NARROW [] +synonym: "stimulation of bone resorption" NARROW [] +synonym: "up regulation of bone resorption" EXACT [] +synonym: "up-regulation of bone resorption" EXACT [] +synonym: "upregulation of bone resorption" EXACT [] +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0045124 ! regulation of bone resorption +is_a: GO:0046852 ! positive regulation of bone remodeling +relationship: positively_regulates GO:0045453 ! bone resorption + +[Term] +id: GO:0045781 +name: negative regulation of cell budding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell budding." [GOC:go_curators] +synonym: "down regulation of cell budding" EXACT [] +synonym: "down-regulation of cell budding" EXACT [] +synonym: "downregulation of cell budding" EXACT [] +synonym: "inhibition of cell budding" NARROW [] +synonym: "negative regulation of budding" BROAD [] +is_a: GO:0007116 ! regulation of cell budding +is_a: GO:0051782 ! negative regulation of cell division +relationship: negatively_regulates GO:0007114 ! cell budding + +[Term] +id: GO:0045782 +name: positive regulation of cell budding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators] +synonym: "activation of cell budding" NARROW [] +synonym: "positive regulation of budding" BROAD [] +synonym: "stimulation of cell budding" NARROW [] +synonym: "up regulation of cell budding" EXACT [] +synonym: "up-regulation of cell budding" EXACT [] +synonym: "upregulation of cell budding" EXACT [] +is_a: GO:0007116 ! regulation of cell budding +is_a: GO:0051781 ! positive regulation of cell division +relationship: positively_regulates GO:0007114 ! cell budding + +[Term] +id: GO:0045783 +name: negative regulation of calcium in ER +namespace: biological_process +def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators] +comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). +is_obsolete: true +consider: GO:0005783 +consider: GO:0006874 + +[Term] +id: GO:0045784 +name: positive regulation of calcium in ER +namespace: biological_process +def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators] +comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). +is_obsolete: true +consider: GO:0005783 +consider: GO:0006874 + +[Term] +id: GO:0045785 +name: positive regulation of cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] +synonym: "activation of cell adhesion" NARROW [] +synonym: "stimulation of cell adhesion" NARROW [] +synonym: "up regulation of cell adhesion" EXACT [] +synonym: "up-regulation of cell adhesion" EXACT [] +synonym: "upregulation of cell adhesion" EXACT [] +is_a: GO:0030155 ! regulation of cell adhesion +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0007155 ! cell adhesion + +[Term] +id: GO:0045786 +name: negative regulation of cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through cell cycle" EXACT [] +synonym: "down-regulation of progression through cell cycle" EXACT [] +synonym: "downregulation of progression through cell cycle" EXACT [] +synonym: "inhibition of progression through cell cycle" NARROW [] +synonym: "negative regulation of cell cycle progression" EXACT [] +synonym: "negative regulation of progression through cell cycle" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051726 ! regulation of cell cycle +relationship: negatively_regulates GO:0007049 ! cell cycle + +[Term] +id: GO:0045787 +name: positive regulation of cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] +synonym: "activation of progression through cell cycle" NARROW [] +synonym: "positive regulation of cell cycle progression" EXACT [] +synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through cell cycle" NARROW [] +synonym: "up regulation of progression through cell cycle" EXACT [] +synonym: "up-regulation of progression through cell cycle" EXACT [] +synonym: "upregulation of progression through cell cycle" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051726 ! regulation of cell cycle +relationship: positively_regulates GO:0007049 ! cell cycle + +[Term] +id: GO:0045792 +name: negative regulation of cell size +namespace: biological_process +def: "Any process that reduces cell size." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of cell size" EXACT [] +synonym: "down-regulation of cell size" EXACT [] +synonym: "downregulation of cell size" EXACT [] +synonym: "inhibition of cell size" NARROW [] +is_a: GO:0008361 ! regulation of cell size + +[Term] +id: GO:0045793 +name: positive regulation of cell size +namespace: biological_process +def: "Any process that increases cell size." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of cell size" NARROW [] +synonym: "stimulation of cell size" NARROW [] +synonym: "up regulation of cell size" EXACT [] +synonym: "up-regulation of cell size" EXACT [] +synonym: "upregulation of cell size" EXACT [] +xref: Reactome:110468 +is_a: GO:0008361 ! regulation of cell size + +[Term] +id: GO:0045794 +name: negative regulation of cell volume +namespace: biological_process +def: "Any process that decreases cell volume." [GOC:go_curators] +synonym: "cell regulatory volume decrease" RELATED [PMID:12388065] +synonym: "RVD" RELATED [PMID:12388065] +is_a: GO:0006884 ! cell volume homeostasis + +[Term] +id: GO:0045795 +name: positive regulation of cell volume +namespace: biological_process +def: "Any process that increases cell volume." [GOC:go_curators] +is_a: GO:0006884 ! cell volume homeostasis + +[Term] +id: GO:0045796 +name: negative regulation of cholesterol absorption +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] +synonym: "down regulation of cholesterol absorption" EXACT [] +synonym: "down-regulation of cholesterol absorption" EXACT [] +synonym: "downregulation of cholesterol absorption" EXACT [] +synonym: "inhibition of cholesterol absorption" NARROW [] +is_a: GO:0030300 ! regulation of cholesterol absorption +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0030299 ! cholesterol absorption + +[Term] +id: GO:0045797 +name: positive regulation of cholesterol absorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] +synonym: "activation of cholesterol absorption" NARROW [] +synonym: "stimulation of cholesterol absorption" NARROW [] +synonym: "up regulation of cholesterol absorption" EXACT [] +synonym: "up-regulation of cholesterol absorption" EXACT [] +synonym: "upregulation of cholesterol absorption" EXACT [] +is_a: GO:0030300 ! regulation of cholesterol absorption +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0030299 ! cholesterol absorption + +[Term] +id: GO:0045798 +name: negative regulation of chromatin assembly or disassembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] +synonym: "down regulation of chromatin assembly or disassembly" EXACT [] +synonym: "down-regulation of chromatin assembly or disassembly" EXACT [] +synonym: "downregulation of chromatin assembly or disassembly" EXACT [] +synonym: "inhibition of chromatin assembly or disassembly" NARROW [] +synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +is_a: GO:0010639 ! negative regulation of organelle organization +relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly + +[Term] +id: GO:0045799 +name: positive regulation of chromatin assembly or disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] +synonym: "activation of chromatin assembly or disassembly" NARROW [] +synonym: "positive regulation of chromatin assembly/disassembly" EXACT [] +synonym: "stimulation of chromatin assembly or disassembly" NARROW [] +synonym: "up regulation of chromatin assembly or disassembly" EXACT [] +synonym: "up-regulation of chromatin assembly or disassembly" EXACT [] +synonym: "upregulation of chromatin assembly or disassembly" EXACT [] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +is_a: GO:0010638 ! positive regulation of organelle organization +relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly + +[Term] +id: GO:0045800 +name: negative regulation of chitin-based cuticle tanning +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jic, GOC:mtg_sensu] +synonym: "down regulation of cuticle tanning" EXACT [] +synonym: "down-regulation of cuticle tanning" EXACT [] +synonym: "downregulation of cuticle tanning" EXACT [] +synonym: "inhibition of cuticle tanning" NARROW [] +synonym: "negative regulation of cuticle hardening" NARROW [] +synonym: "negative regulation of cuticle tanning" EXACT [] +is_a: GO:0007564 ! regulation of chitin-based cuticle tanning +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007593 ! chitin-based cuticle tanning + +[Term] +id: GO:0045801 +name: positive regulation of chitin-based cuticle tanning +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jic, GOC:mtg_sensu] +synonym: "activation of cuticle tanning" NARROW [] +synonym: "positive regulation of cuticle hardening" NARROW [] +synonym: "positive regulation of cuticle tanning" EXACT [] +synonym: "stimulation of cuticle tanning" NARROW [] +synonym: "up regulation of cuticle tanning" EXACT [] +synonym: "up-regulation of cuticle tanning" EXACT [] +synonym: "upregulation of cuticle tanning" EXACT [] +is_a: GO:0007564 ! regulation of chitin-based cuticle tanning +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0007593 ! chitin-based cuticle tanning + +[Term] +id: GO:0045802 +name: negative regulation of cytoskeleton +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] +comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0045803 +name: positive regulation of cytoskeleton +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] +comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0045804 +name: negative regulation of eclosion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eclosion." [GOC:go_curators] +synonym: "down regulation of eclosion" EXACT [] +synonym: "down-regulation of eclosion" EXACT [] +synonym: "downregulation of eclosion" EXACT [] +synonym: "inhibition of eclosion" NARROW [] +is_a: GO:0007563 ! regulation of eclosion +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0007562 ! eclosion + +[Term] +id: GO:0045805 +name: positive regulation of eclosion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators] +synonym: "activation of eclosion" NARROW [] +synonym: "stimulation of eclosion" NARROW [] +synonym: "up regulation of eclosion" EXACT [] +synonym: "up-regulation of eclosion" EXACT [] +synonym: "upregulation of eclosion" EXACT [] +is_a: GO:0007563 ! regulation of eclosion +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0007562 ! eclosion + +[Term] +id: GO:0045806 +name: negative regulation of endocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] +synonym: "down regulation of endocytosis" EXACT [] +synonym: "down-regulation of endocytosis" EXACT [] +synonym: "downregulation of endocytosis" EXACT [] +synonym: "inhibition of endocytosis" NARROW [] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0006897 ! endocytosis + +[Term] +id: GO:0045807 +name: positive regulation of endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] +synonym: "activation of endocytosis" NARROW [] +synonym: "stimulation of endocytosis" NARROW [] +synonym: "up regulation of endocytosis" EXACT [] +synonym: "up-regulation of endocytosis" EXACT [] +synonym: "upregulation of endocytosis" EXACT [] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0006897 ! endocytosis + +[Term] +id: GO:0045808 +name: negative regulation of establishment of competence for transformation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of establishment of competence for transformation" EXACT [] +synonym: "down-regulation of establishment of competence for transformation" EXACT [] +synonym: "downregulation of establishment of competence for transformation" EXACT [] +synonym: "inhibition of establishment of competence for transformation" NARROW [] +synonym: "inhibitor of the establishment of competence for transformation activity" RELATED [] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032105 ! negative regulation of response to extracellular stimulus +is_a: GO:0045304 ! regulation of establishment of competence for transformation +relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation + +[Term] +id: GO:0045809 +name: positive regulation of establishment of competence for transformation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] +synonym: "activation of establishment of competence for transformation" NARROW [] +synonym: "activator of the establishment of competence for transformation activity" RELATED [] +synonym: "stimulation of establishment of competence for transformation" NARROW [] +synonym: "up regulation of establishment of competence for transformation" EXACT [] +synonym: "up-regulation of establishment of competence for transformation" EXACT [] +synonym: "upregulation of establishment of competence for transformation" EXACT [] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0032106 ! positive regulation of response to extracellular stimulus +is_a: GO:0045304 ! regulation of establishment of competence for transformation +relationship: positively_regulates GO:0030420 ! establishment of competence for transformation + +[Term] +id: GO:0045812 +name: negative regulation of Wnt receptor signaling pathway, calcium modulating pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "down-regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "downregulation of frizzled-2 signaling pathway" EXACT [] +synonym: "inhibition of frizzled-2 signaling pathway" NARROW [] +synonym: "negative regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "negative regulation of frizzled-2 signalling pathway" EXACT [] +is_a: GO:0008591 ! regulation of Wnt receptor signaling pathway, calcium modulating pathway +is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway +relationship: negatively_regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway + +[Term] +id: GO:0045813 +name: positive regulation of Wnt receptor signaling pathway, calcium modulating pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the frizzled-2 signaling pathway." [GOC:go_curators] +synonym: "activation of frizzled-2 signaling pathway" NARROW [] +synonym: "positive regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "positive regulation of frizzled-2 signalling pathway" EXACT [] +synonym: "stimulation of frizzled-2 signaling pathway" NARROW [] +synonym: "up regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "up-regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "upregulation of frizzled-2 signaling pathway" EXACT [] +is_a: GO:0008591 ! regulation of Wnt receptor signaling pathway, calcium modulating pathway +is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway +relationship: positively_regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway + +[Term] +id: GO:0045814 +name: negative regulation of gene expression, epigenetic +namespace: biological_process +def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of gene expression, epigenetic" EXACT [] +synonym: "down-regulation of gene expression, epigenetic" EXACT [] +synonym: "downregulation of gene expression, epigenetic" EXACT [] +synonym: "inhibition of gene expression, epigenetic" NARROW [] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0045815 +name: positive regulation of gene expression, epigenetic +namespace: biological_process +def: "Any epigenetic process that activates or increases the rate of gene expression." [GOC:go_curators] +synonym: "activation of gene expression, epigenetic" NARROW [] +synonym: "stimulation of gene expression, epigenetic" NARROW [] +synonym: "up regulation of gene expression, epigenetic" EXACT [] +synonym: "up-regulation of gene expression, epigenetic" EXACT [] +synonym: "upregulation of gene expression, epigenetic" EXACT [] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0045816 +name: negative regulation of transcription from RNA polymerase II promoter, global +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of global transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "down regulation of global transcription from RNA polymerase II promoter" EXACT [] +synonym: "down-regulation of global transcription from RNA polymerase II promoter" EXACT [] +synonym: "downregulation of global transcription from RNA polymerase II promoter" EXACT [] +synonym: "inhibition of global transcription from RNA polymerase II promoter" NARROW [] +synonym: "negative regulation of global transcription from Pol II promoter" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter +is_a: GO:0006358 ! regulation of transcription from RNA polymerase II promoter, global + +[Term] +id: GO:0045817 +name: positive regulation of transcription from RNA polymerase II promoter, global +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of global transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "activation of global transcription from RNA polymerase II promoter" NARROW [] +synonym: "positive regulation of global transcription from Pol II promoter" EXACT [] +synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] +synonym: "up regulation of global transcription from RNA polymerase II promoter" EXACT [] +synonym: "up-regulation of global transcription from RNA polymerase II promoter" EXACT [] +synonym: "upregulation of global transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006358 ! regulation of transcription from RNA polymerase II promoter, global +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0045818 +name: negative regulation of glycogen catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of glycogen catabolic process" EXACT [] +synonym: "down-regulation of glycogen catabolic process" EXACT [] +synonym: "downregulation of glycogen catabolic process" EXACT [] +synonym: "inhibition of glycogen catabolic process" NARROW [] +synonym: "negative regulation of glycogen breakdown" EXACT [] +synonym: "negative regulation of glycogen catabolism" EXACT [] +synonym: "negative regulation of glycogen degradation" EXACT [] +is_a: GO:0005981 ! regulation of glycogen catabolic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +relationship: negatively_regulates GO:0005980 ! glycogen catabolic process + +[Term] +id: GO:0045819 +name: positive regulation of glycogen catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of glycogen catabolic process" NARROW [] +synonym: "positive regulation of glycogen breakdown" EXACT [] +synonym: "positive regulation of glycogen catabolism" EXACT [] +synonym: "positive regulation of glycogen degradation" EXACT [] +synonym: "stimulation of glycogen catabolic process" NARROW [] +synonym: "up regulation of glycogen catabolic process" EXACT [] +synonym: "up-regulation of glycogen catabolic process" EXACT [] +synonym: "upregulation of glycogen catabolic process" EXACT [] +is_a: GO:0005981 ! regulation of glycogen catabolic process +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +relationship: positively_regulates GO:0005980 ! glycogen catabolic process + +[Term] +id: GO:0045820 +name: negative regulation of glycolysis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of glycolysis" EXACT [] +synonym: "down-regulation of glycolysis" EXACT [] +synonym: "downregulation of glycolysis" EXACT [] +synonym: "inhibition of glycolysis" NARROW [] +is_a: GO:0006110 ! regulation of glycolysis +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +relationship: negatively_regulates GO:0006096 ! glycolysis + +[Term] +id: GO:0045821 +name: positive regulation of glycolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of glycolysis" NARROW [] +synonym: "stimulation of glycolysis" NARROW [] +synonym: "up regulation of glycolysis" EXACT [] +synonym: "up-regulation of glycolysis" EXACT [] +synonym: "upregulation of glycolysis" EXACT [] +is_a: GO:0006110 ! regulation of glycolysis +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +relationship: positively_regulates GO:0006096 ! glycolysis + +[Term] +id: GO:0045822 +name: negative regulation of heart contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] +synonym: "down regulation of heart contraction" EXACT [] +synonym: "down-regulation of heart contraction" EXACT [] +synonym: "downregulation of heart contraction" EXACT [] +synonym: "inhibition of heart contraction" NARROW [] +synonym: "negative regulation of cardiac contraction" RELATED [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0060047 ! heart contraction + +[Term] +id: GO:0045823 +name: positive regulation of heart contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] +synonym: "activation of heart contraction" NARROW [] +synonym: "positive regulation of cardiac contraction" EXACT [] +synonym: "stimulation of heart contraction" NARROW [] +synonym: "up regulation of heart contraction" EXACT [] +synonym: "up-regulation of heart contraction" EXACT [] +synonym: "upregulation of heart contraction" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0060047 ! heart contraction + +[Term] +id: GO:0045824 +name: negative regulation of innate immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] +synonym: "down regulation of innate immune response" EXACT [] +synonym: "down-regulation of innate immune response" EXACT [] +synonym: "downregulation of innate immune response" EXACT [] +synonym: "inhibition of innate immune response" NARROW [] +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0045087 ! innate immune response + +[Term] +id: GO:0045825 +name: negative regulation of intermediate filament polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +is_obsolete: true +consider: GO:0030840 +consider: GO:0030843 + +[Term] +id: GO:0045826 +name: positive regulation of intermediate filament polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +is_obsolete: true +consider: GO:0030841 +consider: GO:0030844 + +[Term] +id: GO:0045827 +name: negative regulation of isoprenoid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of isoprenoid metabolic process" EXACT [] +synonym: "down-regulation of isoprenoid metabolic process" EXACT [] +synonym: "downregulation of isoprenoid metabolic process" EXACT [] +synonym: "inhibition of isoprenoid metabolic process" NARROW [] +synonym: "negative regulation of isoprenoid metabolism" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0045828 +name: positive regulation of isoprenoid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of isoprenoid metabolic process" NARROW [] +synonym: "positive regulation of isoprenoid metabolism" EXACT [] +synonym: "stimulation of isoprenoid metabolic process" NARROW [] +synonym: "up regulation of isoprenoid metabolic process" EXACT [] +synonym: "up-regulation of isoprenoid metabolic process" EXACT [] +synonym: "upregulation of isoprenoid metabolic process" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0045829 +name: negative regulation of isotype switching +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators] +synonym: "down regulation of isotype switching" EXACT [] +synonym: "down-regulation of isotype switching" EXACT [] +synonym: "downregulation of isotype switching" EXACT [] +synonym: "inhibition of isotype switching" NARROW [] +synonym: "negative regulation of class switch recombination" EXACT [] +synonym: "negative regulation of class switching" EXACT [] +synonym: "negative regulation of isotype switch recombination" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:0050869 ! negative regulation of B cell activation +relationship: negatively_regulates GO:0045190 ! isotype switching + +[Term] +id: GO:0045830 +name: positive regulation of isotype switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators] +synonym: "activation of isotype switching" NARROW [] +synonym: "positive regulation of class switch recombination" EXACT [] +synonym: "positive regulation of class switching" EXACT [] +synonym: "positive regulation of isotype switch recombination" EXACT [] +synonym: "stimulation of isotype switching" NARROW [] +synonym: "up regulation of isotype switching" EXACT [] +synonym: "up-regulation of isotype switching" EXACT [] +synonym: "upregulation of isotype switching" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +is_a: GO:0045911 ! positive regulation of DNA recombination +is_a: GO:0050871 ! positive regulation of B cell activation +relationship: positively_regulates GO:0045190 ! isotype switching + +[Term] +id: GO:0045831 +name: negative regulation of light-activated channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] +synonym: "down regulation of light-activated channel activity" EXACT [] +synonym: "down-regulation of light-activated channel activity" EXACT [] +synonym: "downregulation of light-activated channel activity" EXACT [] +synonym: "inhibition of light-activated channel activity" NARROW [] +is_a: GO:0016061 ! regulation of light-activated channel activity +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity + +[Term] +id: GO:0045832 +name: positive regulation of light-activated channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] +synonym: "activation of light-activated channel activity" NARROW [] +synonym: "stimulation of light-activated channel activity" NARROW [] +synonym: "up regulation of light-activated channel activity" EXACT [] +synonym: "up-regulation of light-activated channel activity" EXACT [] +synonym: "upregulation of light-activated channel activity" EXACT [] +is_a: GO:0016061 ! regulation of light-activated channel activity +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity + +[Term] +id: GO:0045833 +name: negative regulation of lipid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of lipid metabolic process" EXACT [] +synonym: "down-regulation of lipid metabolic process" EXACT [] +synonym: "downregulation of lipid metabolic process" EXACT [] +synonym: "inhibition of lipid metabolic process" NARROW [] +synonym: "negative regulation of lipid metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: negatively_regulates GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0045834 +name: positive regulation of lipid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of lipid metabolic process" NARROW [] +synonym: "positive regulation of lipid metabolism" EXACT [] +synonym: "stimulation of lipid metabolic process" NARROW [] +synonym: "up regulation of lipid metabolic process" EXACT [] +synonym: "up-regulation of lipid metabolic process" EXACT [] +synonym: "upregulation of lipid metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: positively_regulates GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0045835 +name: negative regulation of meiosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] +synonym: "down regulation of meiosis" EXACT [] +synonym: "down-regulation of meiosis" EXACT [] +synonym: "downregulation of meiosis" EXACT [] +synonym: "inhibition of meiosis" NARROW [] +is_a: GO:0040020 ! regulation of meiosis +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0007126 ! meiosis + +[Term] +id: GO:0045836 +name: positive regulation of meiosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] +synonym: "activation of meiosis" NARROW [] +synonym: "stimulation of meiosis" NARROW [] +synonym: "up regulation of meiosis" EXACT [] +synonym: "up-regulation of meiosis" EXACT [] +synonym: "upregulation of meiosis" EXACT [] +is_a: GO:0040020 ! regulation of meiosis +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0007126 ! meiosis + +[Term] +id: GO:0045837 +name: negative regulation of membrane potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] +synonym: "down regulation of membrane potential" EXACT [] +synonym: "down-regulation of membrane potential" EXACT [] +synonym: "downregulation of membrane potential" EXACT [] +synonym: "inhibition of membrane potential" NARROW [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0045838 +name: positive regulation of membrane potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] +synonym: "activation of membrane potential" NARROW [] +synonym: "stimulation of membrane potential" NARROW [] +synonym: "up regulation of membrane potential" EXACT [] +synonym: "up-regulation of membrane potential" EXACT [] +synonym: "upregulation of membrane potential" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0045839 +name: negative regulation of mitosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of mitosis" EXACT [] +synonym: "down-regulation of mitosis" EXACT [] +synonym: "downregulation of mitosis" EXACT [] +synonym: "inhibition of mitosis" NARROW [] +is_a: GO:0007088 ! regulation of mitosis +is_a: GO:0045786 ! negative regulation of cell cycle +relationship: negatively_regulates GO:0007067 ! mitosis + +[Term] +id: GO:0045840 +name: positive regulation of mitosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] +synonym: "activation of mitosis" NARROW [] +synonym: "mitogenic activity" NARROW [] +synonym: "stimulation of mitosis" NARROW [] +synonym: "up regulation of mitosis" EXACT [] +synonym: "up-regulation of mitosis" EXACT [] +synonym: "upregulation of mitosis" EXACT [] +is_a: GO:0007088 ! regulation of mitosis +is_a: GO:0045787 ! positive regulation of cell cycle +relationship: positively_regulates GO:0007067 ! mitosis + +[Term] +id: GO:0045841 +name: negative regulation of mitotic metaphase/anaphase transition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] +synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW [] +is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition +is_a: GO:0045839 ! negative regulation of mitosis +relationship: negatively_regulates GO:0007091 ! mitotic metaphase/anaphase transition + +[Term] +id: GO:0045842 +name: positive regulation of mitotic metaphase/anaphase transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] +synonym: "activation of mitotic metaphase/anaphase transition" NARROW [] +synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW [] +synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT [] +is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition +is_a: GO:0045840 ! positive regulation of mitosis +relationship: positively_regulates GO:0007091 ! mitotic metaphase/anaphase transition + +[Term] +id: GO:0045843 +name: negative regulation of striated muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] +synonym: "down regulation of striated muscle development" EXACT [] +synonym: "down-regulation of striated muscle development" EXACT [] +synonym: "downregulation of striated muscle development" EXACT [] +synonym: "inhibition of striated muscle development" NARROW [] +is_a: GO:0016202 ! regulation of striated muscle development +is_a: GO:0048635 ! negative regulation of muscle development +relationship: negatively_regulates GO:0014706 ! striated muscle development + +[Term] +id: GO:0045844 +name: positive regulation of striated muscle development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] +synonym: "activation of striated muscle development" NARROW [] +synonym: "stimulation of striated muscle development" NARROW [] +synonym: "up regulation of striated muscle development" EXACT [] +synonym: "up-regulation of striated muscle development" EXACT [] +synonym: "upregulation of striated muscle development" EXACT [] +is_a: GO:0016202 ! regulation of striated muscle development +is_a: GO:0048636 ! positive regulation of muscle development +relationship: positively_regulates GO:0014706 ! striated muscle development + +[Term] +id: GO:0045847 +name: negative regulation of nitrogen utilization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] +synonym: "down regulation of nitrogen utilization" EXACT [] +synonym: "down-regulation of nitrogen utilization" EXACT [] +synonym: "downregulation of nitrogen utilization" EXACT [] +synonym: "inhibition of nitrogen utilization" NARROW [] +is_a: GO:0006808 ! regulation of nitrogen utilization +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0045848 +name: positive regulation of nitrogen utilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] +synonym: "activation of nitrogen utilization" NARROW [] +synonym: "stimulation of nitrogen utilization" NARROW [] +synonym: "up regulation of nitrogen utilization" EXACT [] +synonym: "up-regulation of nitrogen utilization" EXACT [] +synonym: "upregulation of nitrogen utilization" EXACT [] +is_a: GO:0006808 ! regulation of nitrogen utilization +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0045849 +name: negative regulation of nurse cell apoptosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nurse cell apoptosis." [GOC:go_curators] +synonym: "down regulation of nurse cell apoptosis" EXACT [] +synonym: "down-regulation of nurse cell apoptosis" EXACT [] +synonym: "downregulation of nurse cell apoptosis" EXACT [] +synonym: "inhibition of nurse cell apoptosis" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptosis +is_a: GO:0045477 ! regulation of nurse cell apoptosis +relationship: negatively_regulates GO:0045476 ! nurse cell apoptosis + +[Term] +id: GO:0045850 +name: positive regulation of nurse cell apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptosis." [GOC:go_curators] +synonym: "activation of nurse cell apoptosis" NARROW [] +synonym: "stimulation of nurse cell apoptosis" NARROW [] +synonym: "up regulation of nurse cell apoptosis" EXACT [] +synonym: "up-regulation of nurse cell apoptosis" EXACT [] +synonym: "upregulation of nurse cell apoptosis" EXACT [] +is_a: GO:0043065 ! positive regulation of apoptosis +is_a: GO:0045477 ! regulation of nurse cell apoptosis +relationship: positively_regulates GO:0045476 ! nurse cell apoptosis + +[Term] +id: GO:0045851 +name: pH reduction +namespace: biological_process +def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] +synonym: "acidification" EXACT [] +is_a: GO:0006885 ! regulation of pH + +[Term] +id: GO:0045852 +name: pH elevation +namespace: biological_process +def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] +is_a: GO:0006885 ! regulation of pH + +[Term] +id: GO:0045853 +name: negative regulation of bicoid mRNA localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] +synonym: "down regulation of bicoid mRNA localization" EXACT [] +synonym: "down-regulation of bicoid mRNA localization" EXACT [] +synonym: "downregulation of bicoid mRNA localization" EXACT [] +synonym: "inhibition of bicoid mRNA localization" NARROW [] +is_a: GO:0008359 ! regulation of bicoid mRNA localization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization + +[Term] +id: GO:0045854 +name: positive regulation of bicoid mRNA localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] +synonym: "activation of bicoid mRNA localization" NARROW [] +synonym: "stimulation of bicoid mRNA localization" NARROW [] +synonym: "up regulation of bicoid mRNA localization" EXACT [] +synonym: "up-regulation of bicoid mRNA localization" EXACT [] +synonym: "upregulation of bicoid mRNA localization" EXACT [] +is_a: GO:0008359 ! regulation of bicoid mRNA localization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0045450 ! bicoid mRNA localization + +[Term] +id: GO:0045855 +name: negative regulation of pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] +synonym: "down regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "downregulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "inhibition of pole plasm oskar mRNA localization" NARROW [] +synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT [] +is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization + +[Term] +id: GO:0045856 +name: positive regulation of pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] +synonym: "activation of pole plasm oskar mRNA localization" NARROW [] +synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT [] +synonym: "stimulation of pole plasm oskar mRNA localization" NARROW [] +synonym: "up regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "upregulation of pole plasm oskar mRNA localization" EXACT [] +is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization + +[Term] +id: GO:0045857 +name: negative regulation of molecular function, epigenetic +namespace: biological_process +def: "Any heritable epigenetic process that stops, prevents or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of protein activity, epigenetic" EXACT [] +synonym: "down-regulation of protein activity, epigenetic" EXACT [] +synonym: "downregulation of protein activity, epigenetic" EXACT [] +synonym: "inhibition of protein activity, epigenetic" NARROW [] +synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040030 ! regulation of molecular function, epigenetic +is_a: GO:0045814 ! negative regulation of gene expression, epigenetic + +[Term] +id: GO:0045858 +name: positive regulation of molecular function, epigenetic +namespace: biological_process +def: "Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of protein activity, epigenetic" NARROW [] +synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of protein activity, epigenetic" NARROW [] +synonym: "up regulation of protein activity, epigenetic" EXACT [] +synonym: "up-regulation of protein activity, epigenetic" EXACT [] +synonym: "upregulation of protein activity, epigenetic" EXACT [] +is_a: GO:0040030 ! regulation of molecular function, epigenetic +is_a: GO:0045815 ! positive regulation of gene expression, epigenetic + +[Term] +id: GO:0045859 +name: regulation of protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0045860 +name: positive regulation of protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +subset: gosubset_prok +synonym: "stimulation of protein kinase activity" NARROW [] +synonym: "up regulation of protein kinase activity" EXACT [] +synonym: "up-regulation of protein kinase activity" EXACT [] +synonym: "upregulation of protein kinase activity" EXACT [] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0045861 +name: negative regulation of proteolysis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of proteolysis" EXACT [] +synonym: "down-regulation of proteolysis" EXACT [] +synonym: "downregulation of proteolysis" EXACT [] +synonym: "inhibition of proteolysis" NARROW [] +synonym: "negative regulation of peptidolysis" EXACT [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +relationship: negatively_regulates GO:0006508 ! proteolysis + +[Term] +id: GO:0045862 +name: positive regulation of proteolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of proteolysis" NARROW [] +synonym: "positive regulation of peptidolysis" EXACT [] +synonym: "stimulation of proteolysis" NARROW [] +synonym: "up regulation of proteolysis" EXACT [] +synonym: "up-regulation of proteolysis" EXACT [] +synonym: "upregulation of proteolysis" EXACT [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +relationship: positively_regulates GO:0006508 ! proteolysis + +[Term] +id: GO:0045863 +name: negative regulation of pteridine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of pteridine metabolic process" EXACT [] +synonym: "down-regulation of pteridine metabolic process" EXACT [] +synonym: "downregulation of pteridine metabolic process" EXACT [] +synonym: "inhibition of pteridine metabolic process" NARROW [] +synonym: "negative regulation of pteridine metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0042068 ! regulation of pteridine metabolic process +relationship: negatively_regulates GO:0019889 ! pteridine metabolic process + +[Term] +id: GO:0045864 +name: positive regulation of pteridine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of pteridine metabolic process" NARROW [] +synonym: "positive regulation of pteridine metabolism" EXACT [] +synonym: "stimulation of pteridine metabolic process" NARROW [] +synonym: "up regulation of pteridine metabolic process" EXACT [] +synonym: "up-regulation of pteridine metabolic process" EXACT [] +synonym: "upregulation of pteridine metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0042068 ! regulation of pteridine metabolic process +relationship: positively_regulates GO:0019889 ! pteridine metabolic process + +[Term] +id: GO:0045865 +name: regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it describes a substrate-specific process. +is_obsolete: true +replaced_by: GO:0000019 + +[Term] +id: GO:0045866 +name: positive regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it describes a substrate-specific process. +is_obsolete: true +consider: GO:0045951 + +[Term] +id: GO:0045869 +name: negative regulation of retroviral genome replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] +synonym: "down regulation of retroviral genome replication" EXACT [] +synonym: "down-regulation of retroviral genome replication" EXACT [] +synonym: "downregulation of retroviral genome replication" EXACT [] +synonym: "inhibition of retroviral genome replication" NARROW [] +is_a: GO:0045071 ! negative regulation of viral genome replication +is_a: GO:0045091 ! regulation of retroviral genome replication +relationship: negatively_regulates GO:0045090 ! retroviral genome replication + +[Term] +id: GO:0045870 +name: positive regulation of retroviral genome replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] +synonym: "activation of retroviral genome replication" NARROW [] +synonym: "stimulation of retroviral genome replication" NARROW [] +synonym: "up regulation of retroviral genome replication" EXACT [] +synonym: "up-regulation of retroviral genome replication" EXACT [] +synonym: "upregulation of retroviral genome replication" EXACT [] +is_a: GO:0045070 ! positive regulation of viral genome replication +is_a: GO:0045091 ! regulation of retroviral genome replication +relationship: positively_regulates GO:0045090 ! retroviral genome replication + +[Term] +id: GO:0045871 +name: negative regulation of rhodopsin gene expression +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of rhodopsin gene activity" EXACT [] +synonym: "down-regulation of rhodopsin gene activity" EXACT [] +synonym: "downregulation of rhodopsin gene activity" EXACT [] +synonym: "inhibition of rhodopsin gene activity" NARROW [] +synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007468 ! regulation of rhodopsin gene expression +is_a: GO:0010629 ! negative regulation of gene expression + +[Term] +id: GO:0045872 +name: positive regulation of rhodopsin gene expression +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of rhodopsin gene activity" NARROW [] +synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of rhodopsin gene activity" NARROW [] +synonym: "up regulation of rhodopsin gene activity" EXACT [] +synonym: "up-regulation of rhodopsin gene activity" EXACT [] +synonym: "upregulation of rhodopsin gene activity" EXACT [] +is_a: GO:0007468 ! regulation of rhodopsin gene expression +is_a: GO:0010628 ! positive regulation of gene expression + +[Term] +id: GO:0045873 +name: negative regulation of sevenless signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] +synonym: "down regulation of sevenless signaling pathway" EXACT [] +synonym: "down-regulation of sevenless signaling pathway" EXACT [] +synonym: "downregulation of sevenless signaling pathway" EXACT [] +synonym: "inhibition of sevenless signaling pathway" NARROW [] +synonym: "negative regulation of sev signaling pathway" EXACT [] +synonym: "negative regulation of sevenless signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0045501 ! regulation of sevenless signaling pathway +relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway + +[Term] +id: GO:0045874 +name: positive regulation of sevenless signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] +synonym: "activation of sevenless signaling pathway" NARROW [] +synonym: "positive regulation of sev signaling pathway" EXACT [] +synonym: "positive regulation of sevenless signalling pathway" EXACT [] +synonym: "stimulation of sevenless signaling pathway" NARROW [] +synonym: "up regulation of sevenless signaling pathway" EXACT [] +synonym: "up-regulation of sevenless signaling pathway" EXACT [] +synonym: "upregulation of sevenless signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0045501 ! regulation of sevenless signaling pathway +relationship: positively_regulates GO:0045500 ! sevenless signaling pathway + +[Term] +id: GO:0045875 +name: negative regulation of sister chromatid cohesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] +synonym: "down regulation of sister chromatid cohesion" EXACT [] +synonym: "down-regulation of sister chromatid cohesion" EXACT [] +synonym: "downregulation of sister chromatid cohesion" EXACT [] +synonym: "inhibition of sister chromatid cohesion" NARROW [] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +is_a: GO:0010639 ! negative regulation of organelle organization +relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0045876 +name: positive regulation of sister chromatid cohesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] +synonym: "activation of sister chromatid cohesion" NARROW [] +synonym: "stimulation of sister chromatid cohesion" NARROW [] +synonym: "up regulation of sister chromatid cohesion" EXACT [] +synonym: "up-regulation of sister chromatid cohesion" EXACT [] +synonym: "upregulation of sister chromatid cohesion" EXACT [] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +is_a: GO:0010638 ! positive regulation of organelle organization +relationship: positively_regulates GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0045879 +name: negative regulation of smoothened signaling pathway +namespace: biological_process +alt_id: GO:0045877 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] +synonym: "down regulation of smoothened signaling pathway" EXACT [] +synonym: "down-regulation of smoothened signaling pathway" EXACT [] +synonym: "downregulation of smoothened signaling pathway" EXACT [] +synonym: "inhibition of smoothened signaling pathway" NARROW [] +synonym: "negative regulation of smoothened activity" RELATED [] +synonym: "negative regulation of smoothened by patched" NARROW [] +synonym: "negative regulation of smoothened receptor activity by patched" RELATED [] +synonym: "negative regulation of smoothened signalling pathway" EXACT [] +is_a: GO:0008589 ! regulation of smoothened signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0045880 +name: positive regulation of smoothened signaling pathway +namespace: biological_process +alt_id: GO:0045878 +def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] +synonym: "activation of smoothened signaling pathway" NARROW [] +synonym: "positive regulation of smoothened by patched" RELATED [] +synonym: "positive regulation of smoothened receptor activity by patched" RELATED [] +synonym: "positive regulation of smoothened signalling pathway" EXACT [] +synonym: "stimulation of smoothened signaling pathway" NARROW [] +synonym: "up regulation of smoothened signaling pathway" EXACT [] +synonym: "up-regulation of smoothened signaling pathway" EXACT [] +synonym: "upregulation of smoothened signaling pathway" EXACT [] +is_a: GO:0008589 ! regulation of smoothened signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0045881 +name: positive regulation of sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators] +synonym: "activation of sporulation" NARROW [] +synonym: "stimulation of sporulation" NARROW [] +synonym: "up regulation of sporulation" EXACT [] +synonym: "up-regulation of sporulation" EXACT [] +synonym: "upregulation of sporulation" EXACT [] +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0034295 ! basidiospore formation + +[Term] +id: GO:0045882 +name: negative regulation of sulfur utilization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of sulfur utilization" EXACT [] +synonym: "down-regulation of sulfur utilization" EXACT [] +synonym: "downregulation of sulfur utilization" EXACT [] +synonym: "inhibition of sulfur utilization" NARROW [] +synonym: "negative regulation of sulphur utilization" EXACT [] +is_a: GO:0006792 ! regulation of sulfur utilization +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +relationship: negatively_regulates GO:0006791 ! sulfur utilization + +[Term] +id: GO:0045883 +name: positive regulation of sulfur utilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of sulfur utilization" NARROW [] +synonym: "positive regulation of sulphur utilization" EXACT [] +synonym: "stimulation of sulfur utilization" NARROW [] +synonym: "up regulation of sulfur utilization" EXACT [] +synonym: "up-regulation of sulfur utilization" EXACT [] +synonym: "upregulation of sulfur utilization" EXACT [] +is_a: GO:0006792 ! regulation of sulfur utilization +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +relationship: positively_regulates GO:0006791 ! sulfur utilization + +[Term] +id: GO:0045884 +name: regulation of survival gene product expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of survival gene product activity" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of survival gene products" EXACT [] +is_a: GO:0006916 ! anti-apoptosis +is_a: GO:0010468 ! regulation of gene expression + +[Term] +id: GO:0045885 +name: positive regulation of survival gene product expression +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of survival gene product activity" NARROW [] +synonym: "positive regulation of survival gene product activity" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of survival gene products" EXACT [] +synonym: "stimulation of survival gene product activity" NARROW [] +synonym: "up regulation of survival gene product activity" EXACT [] +synonym: "up-regulation of survival gene product activity" EXACT [] +synonym: "upregulation of survival gene product activity" EXACT [] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0045884 ! regulation of survival gene product expression + +[Term] +id: GO:0045886 +name: negative regulation of synaptic growth at neuromuscular junction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] +synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW [] +is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0051964 ! negative regulation of synaptogenesis +relationship: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction + +[Term] +id: GO:0045887 +name: positive regulation of synaptic growth at neuromuscular junction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators] +synonym: "activation of synaptic growth at neuromuscular junction" NARROW [] +synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW [] +synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT [] +is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0051965 ! positive regulation of synaptogenesis +relationship: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction + +[Term] +id: GO:0045888 +name: regulation of transcription of homeotic gene (Polycomb group) +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +is_obsolete: true +consider: GO:0006342 +consider: GO:0048096 + +[Term] +id: GO:0045889 +name: positive regulation of transcription of homeotic gene (Polycomb group) +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +is_obsolete: true +consider: GO:0006342 +consider: GO:0048096 + +[Term] +id: GO:0045890 +name: regulation of transcription of homeotic gene (trithorax group) +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +is_obsolete: true +consider: GO:0006342 +consider: GO:0048096 + +[Term] +id: GO:0045891 +name: negative regulation of transcription of homeotic gene (trithorax group) +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +is_obsolete: true +consider: GO:0006342 +consider: GO:0048096 + +[Term] +id: GO:0045892 +name: negative regulation of transcription, DNA-dependent +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of transcription, DNA-dependent" EXACT [] +synonym: "down-regulation of transcription, DNA-dependent" EXACT [] +synonym: "downregulation of transcription, DNA-dependent" EXACT [] +synonym: "inhibition of transcription, DNA-dependent" NARROW [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0016481 ! negative regulation of transcription +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0045893 +name: positive regulation of transcription, DNA-dependent +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of transcription, DNA-dependent" NARROW [] +synonym: "stimulation of transcription, DNA-dependent" NARROW [] +synonym: "up regulation of transcription, DNA-dependent" EXACT [] +synonym: "up-regulation of transcription, DNA-dependent" EXACT [] +synonym: "upregulation of transcription, DNA-dependent" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0045941 ! positive regulation of transcription +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0006351 ! transcription, DNA-dependent + +[Term] +id: GO:0045894 +name: negative regulation of transcription, mating-type specific +namespace: biological_process +def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription." [GOC:go_curators] +synonym: "down regulation of transcription, mating-type specific" EXACT [] +synonym: "down-regulation of transcription, mating-type specific" EXACT [] +synonym: "downregulation of transcription, mating-type specific" EXACT [] +synonym: "inhibition of transcription, mating-type specific" NARROW [] +is_a: GO:0007532 ! regulation of transcription, mating-type specific +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent + +[Term] +id: GO:0045895 +name: positive regulation of transcription, mating-type specific +namespace: biological_process +def: "Any mating-type specific process that activates or increases the rate of transcription." [GOC:go_curators] +synonym: "activation of transcription, mating-type specific" NARROW [] +synonym: "stimulation of transcription, mating-type specific" NARROW [] +synonym: "up regulation of transcription, mating-type specific" EXACT [] +synonym: "up-regulation of transcription, mating-type specific" EXACT [] +synonym: "upregulation of transcription, mating-type specific" EXACT [] +is_a: GO:0007532 ! regulation of transcription, mating-type specific +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent + +[Term] +id: GO:0045896 +name: regulation of transcription, mitotic +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] +synonym: "mitotic regulation of transcription" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007067 ! mitosis + +[Term] +id: GO:0045897 +name: positive regulation of transcription, mitotic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] +synonym: "activation of transcription, mitotic" NARROW [] +synonym: "mitotic activation of transcription" EXACT [] +synonym: "stimulation of transcription, mitotic" NARROW [] +synonym: "up regulation of transcription, mitotic" EXACT [] +synonym: "up-regulation of transcription, mitotic" EXACT [] +synonym: "upregulation of transcription, mitotic" EXACT [] +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +is_a: GO:0045896 ! regulation of transcription, mitotic + +[Term] +id: GO:0045898 +name: regulation of transcriptional preinitiation complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcriptional preinitiation complex assembly." [GOC:go_curators] +synonym: "regulation of transcriptional pre-initiation complex assembly" EXACT [] +synonym: "regulation of transcriptional pre-initiation complex biosynthesis" EXACT [] +synonym: "regulation of transcriptional preinitiation complex formation" RELATED [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0051123 ! transcriptional preinitiation complex assembly + +[Term] +id: GO:0045899 +name: positive regulation of transcriptional preinitiation complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcriptional preinitiation complex assembly." [GOC:go_curators] +synonym: "activation of transcriptional preinitiation complex assembly" NARROW [] +synonym: "positive regulation of transcriptional pre-initiation complex assembly" EXACT [] +synonym: "positive regulation of transcriptional pre-initiation complex biosynthesis" EXACT [] +synonym: "positive regulation of transcriptional preinitiation complex formation" EXACT [] +synonym: "stimulation of transcriptional preinitiation complex assembly" NARROW [] +synonym: "up regulation of transcriptional preinitiation complex assembly" EXACT [] +synonym: "up-regulation of transcriptional preinitiation complex assembly" EXACT [] +synonym: "upregulation of transcriptional preinitiation complex assembly" EXACT [] +is_a: GO:0045898 ! regulation of transcriptional preinitiation complex assembly +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0051123 ! transcriptional preinitiation complex assembly + +[Term] +id: GO:0045900 +name: negative regulation of translational elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of translational elongation" EXACT [] +synonym: "down-regulation of translational elongation" EXACT [] +synonym: "downregulation of translational elongation" EXACT [] +synonym: "inhibition of translational elongation" NARROW [] +is_a: GO:0006448 ! regulation of translational elongation +is_a: GO:0017148 ! negative regulation of translation +relationship: negatively_regulates GO:0006414 ! translational elongation + +[Term] +id: GO:0045901 +name: positive regulation of translational elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of translational elongation" NARROW [] +synonym: "stimulation of translational elongation" NARROW [] +synonym: "up regulation of translational elongation" EXACT [] +synonym: "up-regulation of translational elongation" EXACT [] +synonym: "upregulation of translational elongation" EXACT [] +is_a: GO:0006448 ! regulation of translational elongation +is_a: GO:0045727 ! positive regulation of translation +relationship: positively_regulates GO:0006414 ! translational elongation + +[Term] +id: GO:0045902 +name: negative regulation of translational fidelity +namespace: biological_process +def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "down regulation of translational fidelity" EXACT [] +synonym: "down-regulation of translational fidelity" EXACT [] +synonym: "downregulation of translational fidelity" EXACT [] +synonym: "inhibition of translational fidelity" NARROW [] +is_a: GO:0006450 ! regulation of translational fidelity +is_a: GO:0017148 ! negative regulation of translation + +[Term] +id: GO:0045903 +name: positive regulation of translational fidelity +namespace: biological_process +def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "activation of translational fidelity" NARROW [] +synonym: "stimulation of translational fidelity" NARROW [] +synonym: "up regulation of translational fidelity" EXACT [] +synonym: "up-regulation of translational fidelity" EXACT [] +synonym: "upregulation of translational fidelity" EXACT [] +is_a: GO:0006450 ! regulation of translational fidelity +is_a: GO:0045727 ! positive regulation of translation + +[Term] +id: GO:0045904 +name: negative regulation of translational termination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of translational termination" EXACT [] +synonym: "down-regulation of translational termination" EXACT [] +synonym: "downregulation of translational termination" EXACT [] +synonym: "inhibition of translational termination" NARROW [] +is_a: GO:0006449 ! regulation of translational termination +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0043242 ! negative regulation of protein complex disassembly +relationship: negatively_regulates GO:0006415 ! translational termination + +[Term] +id: GO:0045905 +name: positive regulation of translational termination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of translational termination" NARROW [] +synonym: "stimulation of translational termination" NARROW [] +synonym: "up regulation of translational termination" EXACT [] +synonym: "up-regulation of translational termination" EXACT [] +synonym: "upregulation of translational termination" EXACT [] +is_a: GO:0006449 ! regulation of translational termination +is_a: GO:0043243 ! positive regulation of protein complex disassembly +is_a: GO:0045727 ! positive regulation of translation +relationship: positively_regulates GO:0006415 ! translational termination + +[Term] +id: GO:0045906 +name: negative regulation of vasoconstriction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators] +synonym: "down regulation of vasoconstriction" EXACT [] +synonym: "down-regulation of vasoconstriction" EXACT [] +synonym: "downregulation of vasoconstriction" EXACT [] +synonym: "inhibition of vasoconstriction" NARROW [] +is_a: GO:0019229 ! regulation of vasoconstriction +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0042310 ! vasoconstriction + +[Term] +id: GO:0045907 +name: positive regulation of vasoconstriction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators] +synonym: "activation of vasoconstriction" NARROW [] +synonym: "stimulation of vasoconstriction" NARROW [] +synonym: "up regulation of vasoconstriction" EXACT [] +synonym: "up-regulation of vasoconstriction" EXACT [] +synonym: "upregulation of vasoconstriction" EXACT [] +is_a: GO:0019229 ! regulation of vasoconstriction +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0042310 ! vasoconstriction + +[Term] +id: GO:0045908 +name: negative regulation of vasodilation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasodilation." [GOC:go_curators] +synonym: "down regulation of vasodilation" EXACT [] +synonym: "down-regulation of vasodilation" EXACT [] +synonym: "downregulation of vasodilation" EXACT [] +synonym: "inhibition of vasodilation" NARROW [] +is_a: GO:0042312 ! regulation of vasodilation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0042311 ! vasodilation + +[Term] +id: GO:0045909 +name: positive regulation of vasodilation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vasodilation." [GOC:go_curators] +synonym: "activation of vasodilation" NARROW [] +synonym: "stimulation of vasodilation" NARROW [] +synonym: "up regulation of vasodilation" EXACT [] +synonym: "up-regulation of vasodilation" EXACT [] +synonym: "upregulation of vasodilation" EXACT [] +is_a: GO:0042312 ! regulation of vasodilation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0042311 ! vasodilation + +[Term] +id: GO:0045910 +name: negative regulation of DNA recombination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of DNA recombination" EXACT [] +synonym: "down-regulation of DNA recombination" EXACT [] +synonym: "downregulation of DNA recombination" EXACT [] +synonym: "inhibition of DNA recombination" NARROW [] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0006310 ! DNA recombination + +[Term] +id: GO:0045911 +name: positive regulation of DNA recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of DNA recombination" NARROW [] +synonym: "stimulation of DNA recombination" NARROW [] +synonym: "up regulation of DNA recombination" EXACT [] +synonym: "up-regulation of DNA recombination" EXACT [] +synonym: "upregulation of DNA recombination" EXACT [] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0006310 ! DNA recombination + +[Term] +id: GO:0045912 +name: negative regulation of carbohydrate metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of carbohydrate metabolic process" EXACT [] +synonym: "down-regulation of carbohydrate metabolic process" EXACT [] +synonym: "downregulation of carbohydrate metabolic process" EXACT [] +synonym: "inhibition of carbohydrate metabolic process" NARROW [] +synonym: "negative regulation of carbohydrate metabolism" EXACT [] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009892 ! negative regulation of metabolic process +relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0045913 +name: positive regulation of carbohydrate metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of carbohydrate metabolic process" NARROW [] +synonym: "positive regulation of carbohydrate metabolism" EXACT [] +synonym: "stimulation of carbohydrate metabolic process" NARROW [] +synonym: "up regulation of carbohydrate metabolic process" EXACT [] +synonym: "up-regulation of carbohydrate metabolic process" EXACT [] +synonym: "upregulation of carbohydrate metabolic process" EXACT [] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009893 ! positive regulation of metabolic process +relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0045914 +name: negative regulation of catecholamine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of catecholamine metabolic process" EXACT [] +synonym: "down-regulation of catecholamine metabolic process" EXACT [] +synonym: "downregulation of catecholamine metabolic process" EXACT [] +synonym: "inhibition of catecholamine metabolic process" NARROW [] +synonym: "negative regulation of catecholamine metabolism" EXACT [] +is_a: GO:0033239 ! negative regulation of amine metabolic process +is_a: GO:0042069 ! regulation of catecholamine metabolic process +relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0045915 +name: positive regulation of catecholamine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of catecholamine metabolic process" NARROW [] +synonym: "positive regulation of catecholamine metabolism" EXACT [] +synonym: "stimulation of catecholamine metabolic process" NARROW [] +synonym: "up regulation of catecholamine metabolic process" EXACT [] +synonym: "up-regulation of catecholamine metabolic process" EXACT [] +synonym: "upregulation of catecholamine metabolic process" EXACT [] +is_a: GO:0033240 ! positive regulation of amine metabolic process +is_a: GO:0042069 ! regulation of catecholamine metabolic process +relationship: positively_regulates GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0045916 +name: negative regulation of complement activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement activation." [GOC:go_curators] +synonym: "down regulation of complement activation" EXACT [] +synonym: "down-regulation of complement activation" EXACT [] +synonym: "downregulation of complement activation" EXACT [] +synonym: "inhibition of complement activation" NARROW [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0045861 ! negative regulation of proteolysis +relationship: negatively_regulates GO:0006956 ! complement activation + +[Term] +id: GO:0045917 +name: positive regulation of complement activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators] +synonym: "activation of complement activation" NARROW [] +synonym: "stimulation of complement activation" NARROW [] +synonym: "up regulation of complement activation" EXACT [] +synonym: "up-regulation of complement activation" EXACT [] +synonym: "upregulation of complement activation" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0045862 ! positive regulation of proteolysis +relationship: positively_regulates GO:0006956 ! complement activation + +[Term] +id: GO:0045918 +name: negative regulation of cytolysis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of cytolysis" EXACT [] +synonym: "down-regulation of cytolysis" EXACT [] +synonym: "downregulation of cytolysis" EXACT [] +synonym: "inhibition of cytolysis" NARROW [] +is_a: GO:0042268 ! regulation of cytolysis +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0019835 ! cytolysis + +[Term] +id: GO:0045919 +name: positive regulation of cytolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of cytolysis" NARROW [] +synonym: "stimulation of cytolysis" NARROW [] +synonym: "up regulation of cytolysis" EXACT [] +synonym: "up-regulation of cytolysis" EXACT [] +synonym: "upregulation of cytolysis" EXACT [] +is_a: GO:0042268 ! regulation of cytolysis +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0019835 ! cytolysis + +[Term] +id: GO:0045920 +name: negative regulation of exocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] +synonym: "down regulation of exocytosis" EXACT [] +synonym: "down-regulation of exocytosis" EXACT [] +synonym: "downregulation of exocytosis" EXACT [] +synonym: "inhibition of exocytosis" NARROW [] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0006887 ! exocytosis + +[Term] +id: GO:0045921 +name: positive regulation of exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of exocytosis" NARROW [] +synonym: "stimulation of exocytosis" NARROW [] +synonym: "up regulation of exocytosis" EXACT [] +synonym: "up-regulation of exocytosis" EXACT [] +synonym: "upregulation of exocytosis" EXACT [] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0006887 ! exocytosis + +[Term] +id: GO:0045922 +name: negative regulation of fatty acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of fatty acid metabolic process" EXACT [] +synonym: "down-regulation of fatty acid metabolic process" EXACT [] +synonym: "downregulation of fatty acid metabolic process" EXACT [] +synonym: "inhibition of fatty acid metabolic process" NARROW [] +synonym: "negative regulation of fatty acid metabolism" EXACT [] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0045923 +name: positive regulation of fatty acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of fatty acid metabolic process" NARROW [] +synonym: "positive regulation of fatty acid metabolism" EXACT [] +synonym: "stimulation of fatty acid metabolic process" NARROW [] +synonym: "up regulation of fatty acid metabolic process" EXACT [] +synonym: "up-regulation of fatty acid metabolic process" EXACT [] +synonym: "upregulation of fatty acid metabolic process" EXACT [] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +relationship: positively_regulates GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0045924 +name: regulation of female receptivity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:go_curators] +is_a: GO:0043900 ! regulation of multi-organism process +is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0060181 ! female receptivity + +[Term] +id: GO:0045925 +name: positive regulation of female receptivity +namespace: biological_process +def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators] +synonym: "activation of female receptivity" NARROW [] +synonym: "stimulation of female receptivity" NARROW [] +synonym: "up regulation of female receptivity" EXACT [] +synonym: "up-regulation of female receptivity" EXACT [] +synonym: "upregulation of female receptivity" EXACT [] +is_a: GO:0045924 ! regulation of female receptivity +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0060181 ! female receptivity + +[Term] +id: GO:0045926 +name: negative regulation of growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of growth" EXACT [] +synonym: "down-regulation of growth" EXACT [] +synonym: "downregulation of growth" EXACT [] +synonym: "inhibition of growth" NARROW [] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0040007 ! growth + +[Term] +id: GO:0045927 +name: positive regulation of growth +namespace: biological_process +def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of growth" NARROW [] +synonym: "stimulation of growth" NARROW [] +synonym: "up regulation of growth" EXACT [] +synonym: "up-regulation of growth" EXACT [] +synonym: "upregulation of growth" EXACT [] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0040007 ! growth + +[Term] +id: GO:0045928 +name: negative regulation of juvenile hormone metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone metabolic process" EXACT [] +synonym: "down-regulation of juvenile hormone metabolic process" EXACT [] +synonym: "downregulation of juvenile hormone metabolic process" EXACT [] +synonym: "inhibition of juvenile hormone metabolic process" NARROW [] +synonym: "negative regulation of juvenile hormone metabolism" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process + +[Term] +id: GO:0045929 +name: positive regulation of juvenile hormone metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone metabolic process" NARROW [] +synonym: "positive regulation of juvenile hormone metabolism" EXACT [] +synonym: "stimulation of juvenile hormone metabolic process" NARROW [] +synonym: "up regulation of juvenile hormone metabolic process" EXACT [] +synonym: "up-regulation of juvenile hormone metabolic process" EXACT [] +synonym: "upregulation of juvenile hormone metabolic process" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process + +[Term] +id: GO:0045930 +name: negative regulation of mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through mitotic cell cycle" NARROW [] +synonym: "negative regulation of mitotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0045786 ! negative regulation of cell cycle +relationship: negatively_regulates GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0045931 +name: positive regulation of mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of progression through mitotic cell cycle" NARROW [] +synonym: "positive regulation of mitotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through mitotic cell cycle" NARROW [] +synonym: "up regulation of progression through mitotic cell cycle" EXACT [] +synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] +synonym: "upregulation of progression through mitotic cell cycle" EXACT [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0045787 ! positive regulation of cell cycle +relationship: positively_regulates GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0045932 +name: negative regulation of muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] +synonym: "down regulation of muscle contraction" EXACT [] +synonym: "down-regulation of muscle contraction" EXACT [] +synonym: "downregulation of muscle contraction" EXACT [] +synonym: "inhibition of muscle contraction" NARROW [] +is_a: GO:0006937 ! regulation of muscle contraction +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0006936 ! muscle contraction + +[Term] +id: GO:0045933 +name: positive regulation of muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] +synonym: "activation of muscle contraction" NARROW [] +synonym: "stimulation of muscle contraction" NARROW [] +synonym: "up regulation of muscle contraction" EXACT [] +synonym: "up-regulation of muscle contraction" EXACT [] +synonym: "upregulation of muscle contraction" EXACT [] +is_a: GO:0006937 ! regulation of muscle contraction +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0006936 ! muscle contraction + +[Term] +id: GO:0045934 +name: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] +synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +relationship: negatively_regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process + +[Term] +id: GO:0045935 +name: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] +synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] +synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +relationship: positively_regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process + +[Term] +id: GO:0045936 +name: negative regulation of phosphate metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of phosphate metabolic process" EXACT [] +synonym: "down-regulation of phosphate metabolic process" EXACT [] +synonym: "downregulation of phosphate metabolic process" EXACT [] +synonym: "inhibition of phosphate metabolic process" NARROW [] +synonym: "negative regulation of phosphate metabolism" EXACT [] +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: negatively_regulates GO:0006796 ! phosphate metabolic process + +[Term] +id: GO:0045937 +name: positive regulation of phosphate metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of phosphate metabolic process" NARROW [] +synonym: "positive regulation of phosphate metabolism" EXACT [] +synonym: "stimulation of phosphate metabolic process" NARROW [] +synonym: "up regulation of phosphate metabolic process" EXACT [] +synonym: "up-regulation of phosphate metabolic process" EXACT [] +synonym: "upregulation of phosphate metabolic process" EXACT [] +is_a: GO:0010562 ! positive regulation of phosphorus metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: positively_regulates GO:0006796 ! phosphate metabolic process + +[Term] +id: GO:0045938 +name: positive regulation of circadian sleep/wake cycle, sleep +namespace: biological_process +def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] +synonym: "activation of circadian sleep/wake cycle, sleep" NARROW [] +synonym: "positive regulation of sleep" EXACT [] +synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW [] +synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT [] +is_a: GO:0042753 ! positive regulation of circadian rhythm +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0045939 +name: negative regulation of steroid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of steroid metabolic process" EXACT [] +synonym: "down-regulation of steroid metabolic process" EXACT [] +synonym: "downregulation of steroid metabolic process" EXACT [] +synonym: "inhibition of steroid metabolic process" NARROW [] +synonym: "negative regulation of steroid metabolism" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +relationship: negatively_regulates GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0045940 +name: positive regulation of steroid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of steroid metabolic process" NARROW [] +synonym: "positive regulation of steroid metabolism" EXACT [] +synonym: "stimulation of steroid metabolic process" NARROW [] +synonym: "up regulation of steroid metabolic process" EXACT [] +synonym: "up-regulation of steroid metabolic process" EXACT [] +synonym: "upregulation of steroid metabolic process" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +relationship: positively_regulates GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0045941 +name: positive regulation of transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of transcription" NARROW [] +synonym: "stimulation of transcription" NARROW [] +synonym: "up regulation of transcription" EXACT [] +synonym: "up-regulation of transcription" EXACT [] +synonym: "upregulation of transcription" EXACT [] +xref: Reactome:163765 +xref: Reactome:211800 +xref: Reactome:221564 +xref: Reactome:230170 +xref: Reactome:238201 +xref: Reactome:244782 +xref: Reactome:249686 +xref: Reactome:252601 +xref: Reactome:255788 +xref: Reactome:259182 +xref: Reactome:262538 +xref: Reactome:265363 +xref: Reactome:268491 +xref: Reactome:274218 +xref: Reactome:280687 +xref: Reactome:282896 +xref: Reactome:286706 +xref: Reactome:288369 +xref: Reactome:289870 +xref: Reactome:290405 +xref: Reactome:291788 +xref: Reactome:292436 +xref: Reactome:293769 +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045449 ! regulation of transcription +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: positively_regulates GO:0006350 ! transcription + +[Term] +id: GO:0045942 +name: negative regulation of phosphorus utilization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of phosphorus utilization" EXACT [] +synonym: "down-regulation of phosphorus utilization" EXACT [] +synonym: "downregulation of phosphorus utilization" EXACT [] +synonym: "inhibition of phosphorus utilization" NARROW [] +is_a: GO:0006795 ! regulation of phosphorus utilization +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +relationship: negatively_regulates GO:0006794 ! phosphorus utilization + +[Term] +id: GO:0045943 +name: positive regulation of transcription from RNA polymerase I promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase I promoter." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase I promoter" NARROW [] +synonym: "positive regulation of transcription from Pol I promoter" EXACT [] +synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW [] +synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT [] +is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +relationship: positively_regulates GO:0006360 ! transcription from RNA polymerase I promoter + +[Term] +id: GO:0045944 +name: positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase II promoter" NARROW [] +synonym: "positive regulation of transcription from Pol II promoter" EXACT [] +synonym: "stimulation of transcription from RNA polymerase II promoter" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter + +[Term] +id: GO:0045945 +name: positive regulation of transcription from RNA polymerase III promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase III promoter." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase III promoter" NARROW [] +synonym: "positive regulation of transcription from Pol III promoter" EXACT [] +synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW [] +synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT [] +is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +relationship: positively_regulates GO:0006383 ! transcription from RNA polymerase III promoter + +[Term] +id: GO:0045947 +name: negative regulation of translational initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of translational initiation" EXACT [] +synonym: "down-regulation of translational initiation" EXACT [] +synonym: "downregulation of translational initiation" EXACT [] +synonym: "inhibition of translational initiation" NARROW [] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0006413 ! translational initiation + +[Term] +id: GO:0045948 +name: positive regulation of translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of translational initiation" NARROW [] +synonym: "stimulation of translational initiation" NARROW [] +synonym: "up regulation of translational initiation" EXACT [] +synonym: "up-regulation of translational initiation" EXACT [] +synonym: "upregulation of translational initiation" EXACT [] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0006413 ! translational initiation + +[Term] +id: GO:0045949 +name: positive regulation of phosphorus utilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of phosphorus utilization" NARROW [] +synonym: "stimulation of phosphorus utilization" NARROW [] +synonym: "up regulation of phosphorus utilization" EXACT [] +synonym: "up-regulation of phosphorus utilization" EXACT [] +synonym: "upregulation of phosphorus utilization" EXACT [] +is_a: GO:0006795 ! regulation of phosphorus utilization +is_a: GO:0010562 ! positive regulation of phosphorus metabolic process +relationship: positively_regulates GO:0006794 ! phosphorus utilization + +[Term] +id: GO:0045950 +name: negative regulation of mitotic recombination +namespace: biological_process +def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd] +synonym: "down regulation of mitotic recombination" EXACT [] +synonym: "down-regulation of mitotic recombination" EXACT [] +synonym: "downregulation of mitotic recombination" EXACT [] +synonym: "inhibition of mitotic recombination" NARROW [] +synonym: "negative regulation of recombination within rDNA repeats" NARROW [] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0045910 ! negative regulation of DNA recombination +relationship: negatively_regulates GO:0006312 ! mitotic recombination + +[Term] +id: GO:0045951 +name: positive regulation of mitotic recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] +synonym: "activation of mitotic recombination" NARROW [] +synonym: "positive regulation of recombination within rDNA repeats" NARROW [] +synonym: "stimulation of mitotic recombination" NARROW [] +synonym: "up regulation of mitotic recombination" EXACT [] +synonym: "up-regulation of mitotic recombination" EXACT [] +synonym: "upregulation of mitotic recombination" EXACT [] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0045911 ! positive regulation of DNA recombination +relationship: positively_regulates GO:0006312 ! mitotic recombination + +[Term] +id: GO:0045952 +name: regulation of juvenile hormone catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] +synonym: "regulation of juvenile hormone breakdown" EXACT [] +synonym: "regulation of juvenile hormone catabolism" EXACT [] +synonym: "regulation of juvenile hormone degradation" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0006719 ! juvenile hormone catabolic process + +[Term] +id: GO:0045953 +name: negative regulation of natural killer cell mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW [] +synonym: "negative regulation of natural killer cell mediated cell death" EXACT [] +synonym: "negative regulation of natural killer cell mediated cell killing" EXACT [] +synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED [] +synonym: "negative regulation of NK cell mediated cell death" EXACT [] +synonym: "negative regulation of NK cell mediated cell killing" EXACT [] +synonym: "negative regulation of NK cell mediated cytolysis" RELATED [] +synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0045954 +name: positive regulation of natural killer cell mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "activation of natural killer cell mediated cytotoxicity" NARROW [] +synonym: "positive regulation of natural killer cell mediated cell death" EXACT [] +synonym: "positive regulation of natural killer cell mediated cell killing" EXACT [] +synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED [] +synonym: "positive regulation of NK cell mediated cell death" EXACT [] +synonym: "positive regulation of NK cell mediated cell killing" EXACT [] +synonym: "positive regulation of NK cell mediated cytolysis" RELATED [] +synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT [] +synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW [] +synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT [] +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0045955 +name: negative regulation of calcium ion-dependent exocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] +synonym: "down regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "downregulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "inhibition of calcium ion-dependent exocytosis" NARROW [] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +is_a: GO:0045920 ! negative regulation of exocytosis +relationship: negatively_regulates GO:0017156 ! calcium ion-dependent exocytosis + +[Term] +id: GO:0045956 +name: positive regulation of calcium ion-dependent exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] +synonym: "activation of calcium ion-dependent exocytosis" NARROW [] +synonym: "stimulation of calcium ion-dependent exocytosis" NARROW [] +synonym: "up regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "upregulation of calcium ion-dependent exocytosis" EXACT [] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +is_a: GO:0045921 ! positive regulation of exocytosis +relationship: positively_regulates GO:0017156 ! calcium ion-dependent exocytosis + +[Term] +id: GO:0045957 +name: negative regulation of complement activation, alternative pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] +synonym: "down regulation of complement activation, alternative pathway" EXACT [] +synonym: "down-regulation of complement activation, alternative pathway" EXACT [] +synonym: "downregulation of complement activation, alternative pathway" EXACT [] +synonym: "inhibition of complement activation, alternative pathway" NARROW [] +is_a: GO:0030451 ! regulation of complement activation, alternative pathway +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway + +[Term] +id: GO:0045958 +name: positive regulation of complement activation, alternative pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] +synonym: "activation of complement activation, alternative pathway" NARROW [] +synonym: "stimulation of complement activation, alternative pathway" NARROW [] +synonym: "up regulation of complement activation, alternative pathway" EXACT [] +synonym: "up-regulation of complement activation, alternative pathway" EXACT [] +synonym: "upregulation of complement activation, alternative pathway" EXACT [] +is_a: GO:0030451 ! regulation of complement activation, alternative pathway +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway + +[Term] +id: GO:0045959 +name: negative regulation of complement activation, classical pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] +synonym: "down regulation of complement activation, classical pathway" EXACT [] +synonym: "down-regulation of complement activation, classical pathway" EXACT [] +synonym: "downregulation of complement activation, classical pathway" EXACT [] +synonym: "inhibition of complement activation, classical pathway" NARROW [] +is_a: GO:0030450 ! regulation of complement activation, classical pathway +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway + +[Term] +id: GO:0045960 +name: positive regulation of complement activation, classical pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] +synonym: "activation of complement activation, classical pathway" NARROW [] +synonym: "stimulation of complement activation, classical pathway" NARROW [] +synonym: "up regulation of complement activation, classical pathway" EXACT [] +synonym: "up-regulation of complement activation, classical pathway" EXACT [] +synonym: "upregulation of complement activation, classical pathway" EXACT [] +is_a: GO:0030450 ! regulation of complement activation, classical pathway +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0006958 ! complement activation, classical pathway + +[Term] +id: GO:0045961 +name: negative regulation of development, heterochronic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heterochronic development." [GOC:go_curators] +synonym: "down regulation of development, heterochronic" EXACT [] +synonym: "down-regulation of development, heterochronic" EXACT [] +synonym: "downregulation of development, heterochronic" EXACT [] +synonym: "inhibition of development, heterochronic" NARROW [] +is_a: GO:0040034 ! regulation of development, heterochronic + +[Term] +id: GO:0045962 +name: positive regulation of development, heterochronic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heterochronic development." [GOC:go_curators] +synonym: "activation of development, heterochronic" NARROW [] +synonym: "stimulation of development, heterochronic" NARROW [] +synonym: "up regulation of development, heterochronic" EXACT [] +synonym: "up-regulation of development, heterochronic" EXACT [] +synonym: "upregulation of development, heterochronic" EXACT [] +is_a: GO:0040034 ! regulation of development, heterochronic + +[Term] +id: GO:0045963 +name: negative regulation of dopamine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] +synonym: "down regulation of dopamine metabolic process" EXACT [] +synonym: "down-regulation of dopamine metabolic process" EXACT [] +synonym: "downregulation of dopamine metabolic process" EXACT [] +synonym: "inhibition of dopamine metabolic process" NARROW [] +synonym: "negative regulation of dopamine metabolism" EXACT [] +is_a: GO:0042053 ! regulation of dopamine metabolic process +is_a: GO:0045914 ! negative regulation of catecholamine metabolic process +relationship: negatively_regulates GO:0042417 ! dopamine metabolic process + +[Term] +id: GO:0045964 +name: positive regulation of dopamine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] +synonym: "activation of dopamine metabolic process" NARROW [] +synonym: "positive regulation of dopamine metabolism" EXACT [] +synonym: "stimulation of dopamine metabolic process" NARROW [] +synonym: "up regulation of dopamine metabolic process" EXACT [] +synonym: "up-regulation of dopamine metabolic process" EXACT [] +synonym: "upregulation of dopamine metabolic process" EXACT [] +is_a: GO:0042053 ! regulation of dopamine metabolic process +is_a: GO:0045915 ! positive regulation of catecholamine metabolic process +relationship: positively_regulates GO:0042417 ! dopamine metabolic process + +[Term] +id: GO:0045965 +name: negative regulation of ecdysteroid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] +synonym: "down regulation of ecdysteroid metabolic process" EXACT [] +synonym: "down-regulation of ecdysteroid metabolic process" EXACT [] +synonym: "downregulation of ecdysteroid metabolic process" EXACT [] +synonym: "inhibition of ecdysteroid metabolic process" NARROW [] +synonym: "negative regulation of ecdysteroid metabolism" EXACT [] +is_a: GO:0007553 ! regulation of ecdysteroid metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0045966 +name: positive regulation of ecdysteroid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] +synonym: "activation of ecdysteroid metabolic process" NARROW [] +synonym: "positive regulation of ecdysteroid metabolism" EXACT [] +synonym: "stimulation of ecdysteroid metabolic process" NARROW [] +synonym: "up regulation of ecdysteroid metabolic process" EXACT [] +synonym: "up-regulation of ecdysteroid metabolic process" EXACT [] +synonym: "upregulation of ecdysteroid metabolic process" EXACT [] +is_a: GO:0007553 ! regulation of ecdysteroid metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0045967 +name: negative regulation of growth rate +namespace: biological_process +def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah] +comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. +synonym: "down regulation of growth rate" EXACT [] +synonym: "down-regulation of growth rate" EXACT [] +synonym: "downregulation of growth rate" EXACT [] +synonym: "inhibition of growth rate" NARROW [] +is_a: GO:0040009 ! regulation of growth rate +is_a: GO:0045926 ! negative regulation of growth + +[Term] +id: GO:0045968 +name: negative regulation of juvenile hormone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "downregulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "inhibition of juvenile hormone biosynthetic process" NARROW [] +synonym: "negative regulation of juvenile hormone anabolism" EXACT [] +synonym: "negative regulation of juvenile hormone biosynthesis" EXACT [] +synonym: "negative regulation of juvenile hormone formation" EXACT [] +synonym: "negative regulation of juvenile hormone synthesis" EXACT [] +is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process + +[Term] +id: GO:0045969 +name: positive regulation of juvenile hormone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone biosynthetic process" NARROW [] +synonym: "positive regulation of juvenile hormone anabolism" EXACT [] +synonym: "positive regulation of juvenile hormone biosynthesis" EXACT [] +synonym: "positive regulation of juvenile hormone formation" EXACT [] +synonym: "positive regulation of juvenile hormone synthesis" EXACT [] +synonym: "stimulation of juvenile hormone biosynthetic process" NARROW [] +synonym: "up regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "upregulation of juvenile hormone biosynthetic process" EXACT [] +is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process +is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process + +[Term] +id: GO:0045970 +name: negative regulation of juvenile hormone catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone catabolic process" EXACT [] +synonym: "down-regulation of juvenile hormone catabolic process" EXACT [] +synonym: "downregulation of juvenile hormone catabolic process" EXACT [] +synonym: "inhibition of juvenile hormone catabolic process" NARROW [] +synonym: "negative regulation of juvenile hormone breakdown" EXACT [] +synonym: "negative regulation of juvenile hormone catabolism" EXACT [] +synonym: "negative regulation of juvenile hormone degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process +is_a: GO:0045952 ! regulation of juvenile hormone catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process + +[Term] +id: GO:0045971 +name: positive regulation of juvenile hormone catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone catabolic process" NARROW [] +synonym: "positive regulation of juvenile hormone breakdown" EXACT [] +synonym: "positive regulation of juvenile hormone catabolism" EXACT [] +synonym: "positive regulation of juvenile hormone degradation" EXACT [] +synonym: "stimulation of juvenile hormone catabolic process" NARROW [] +synonym: "up regulation of juvenile hormone catabolic process" EXACT [] +synonym: "up-regulation of juvenile hormone catabolic process" EXACT [] +synonym: "upregulation of juvenile hormone catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process +is_a: GO:0045952 ! regulation of juvenile hormone catabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process + +[Term] +id: GO:0045972 +name: negative regulation of juvenile hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone secretion" EXACT [] +synonym: "down-regulation of juvenile hormone secretion" EXACT [] +synonym: "downregulation of juvenile hormone secretion" EXACT [] +synonym: "inhibition of juvenile hormone secretion" NARROW [] +is_a: GO:0007558 ! regulation of juvenile hormone secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion + +[Term] +id: GO:0045973 +name: positive regulation of juvenile hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone secretion" NARROW [] +synonym: "stimulation of juvenile hormone secretion" NARROW [] +synonym: "up regulation of juvenile hormone secretion" EXACT [] +synonym: "up-regulation of juvenile hormone secretion" EXACT [] +synonym: "upregulation of juvenile hormone secretion" EXACT [] +is_a: GO:0007558 ! regulation of juvenile hormone secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0045443 ! juvenile hormone secretion + +[Term] +id: GO:0045974 +name: regulation of translation, ncRNA-mediated +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0045975 +name: positive regulation of translation, ncRNA-mediated +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of mRNA translation, ncRNA-mediated" NARROW [] +synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW [] +synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT [] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0045974 ! regulation of translation, ncRNA-mediated + +[Term] +id: GO:0045976 +name: negative regulation of mitotic cell cycle, embryonic +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW [] +synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0045977 +name: positive regulation of mitotic cell cycle, embryonic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of mitotic cell cycle, embryonic" NARROW [] +synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of mitotic cell cycle, embryonic" NARROW [] +synonym: "up regulation of mitotic cell cycle, embryonic" EXACT [] +synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT [] +synonym: "upregulation of mitotic cell cycle, embryonic" EXACT [] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0045978 +name: negative regulation of nucleoside metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of nucleoside metabolic process" EXACT [] +synonym: "down-regulation of nucleoside metabolic process" EXACT [] +synonym: "downregulation of nucleoside metabolic process" EXACT [] +synonym: "inhibition of nucleoside metabolic process" NARROW [] +synonym: "negative regulation of nucleoside metabolism" EXACT [] +is_a: GO:0009118 ! regulation of nucleoside metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0045979 +name: positive regulation of nucleoside metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of nucleoside metabolic process" NARROW [] +synonym: "positive regulation of nucleoside metabolism" EXACT [] +synonym: "stimulation of nucleoside metabolic process" NARROW [] +synonym: "up regulation of nucleoside metabolic process" EXACT [] +synonym: "up-regulation of nucleoside metabolic process" EXACT [] +synonym: "upregulation of nucleoside metabolic process" EXACT [] +is_a: GO:0009118 ! regulation of nucleoside metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: positively_regulates GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0045980 +name: negative regulation of nucleotide metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of nucleotide metabolic process" EXACT [] +synonym: "down-regulation of nucleotide metabolic process" EXACT [] +synonym: "downregulation of nucleotide metabolic process" EXACT [] +synonym: "inhibition of nucleotide metabolic process" NARROW [] +synonym: "negative regulation of nucleotide metabolism" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0045981 +name: positive regulation of nucleotide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of nucleotide metabolic process" NARROW [] +synonym: "positive regulation of nucleotide metabolism" EXACT [] +synonym: "stimulation of nucleotide metabolic process" NARROW [] +synonym: "up regulation of nucleotide metabolic process" EXACT [] +synonym: "up-regulation of nucleotide metabolic process" EXACT [] +synonym: "upregulation of nucleotide metabolic process" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: positively_regulates GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0045982 +name: negative regulation of purine base metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of purine base metabolic process" EXACT [] +synonym: "down-regulation of purine base metabolic process" EXACT [] +synonym: "downregulation of purine base metabolic process" EXACT [] +synonym: "inhibition of purine base metabolic process" NARROW [] +synonym: "negative regulation of purine base metabolism" EXACT [] +is_a: GO:0006141 ! regulation of purine base metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: negatively_regulates GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0045983 +name: positive regulation of purine base metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of purine base metabolic process" NARROW [] +synonym: "positive regulation of purine base metabolism" EXACT [] +synonym: "stimulation of purine base metabolic process" NARROW [] +synonym: "up regulation of purine base metabolic process" EXACT [] +synonym: "up-regulation of purine base metabolic process" EXACT [] +synonym: "upregulation of purine base metabolic process" EXACT [] +is_a: GO:0006141 ! regulation of purine base metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: positively_regulates GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0045984 +name: negative regulation of pyrimidine base metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of pyrimidine base metabolic process" EXACT [] +synonym: "down-regulation of pyrimidine base metabolic process" EXACT [] +synonym: "downregulation of pyrimidine base metabolic process" EXACT [] +synonym: "inhibition of pyrimidine base metabolic process" NARROW [] +synonym: "negative regulation of pyrimidine base metabolism" EXACT [] +is_a: GO:0006142 ! regulation of pyrimidine base metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: negatively_regulates GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0045985 +name: positive regulation of pyrimidine base metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of pyrimidine base metabolic process" NARROW [] +synonym: "positive regulation of pyrimidine base metabolism" EXACT [] +synonym: "stimulation of pyrimidine base metabolic process" NARROW [] +synonym: "up regulation of pyrimidine base metabolic process" EXACT [] +synonym: "up-regulation of pyrimidine base metabolic process" EXACT [] +synonym: "upregulation of pyrimidine base metabolic process" EXACT [] +is_a: GO:0006142 ! regulation of pyrimidine base metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: positively_regulates GO:0006206 ! pyrimidine base metabolic process + +[Term] +id: GO:0045986 +name: negative regulation of smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] +synonym: "down regulation of smooth muscle contraction" EXACT [] +synonym: "down-regulation of smooth muscle contraction" EXACT [] +synonym: "downregulation of smooth muscle contraction" EXACT [] +synonym: "inhibition of smooth muscle contraction" NARROW [] +synonym: "smooth muscle relaxation" RELATED [] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0045932 ! negative regulation of muscle contraction +relationship: negatively_regulates GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0045987 +name: positive regulation of smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] +synonym: "activation of smooth muscle contraction" NARROW [] +synonym: "stimulation of smooth muscle contraction" NARROW [] +synonym: "up regulation of smooth muscle contraction" EXACT [] +synonym: "up-regulation of smooth muscle contraction" EXACT [] +synonym: "upregulation of smooth muscle contraction" EXACT [] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0045933 ! positive regulation of muscle contraction +relationship: positively_regulates GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0045988 +name: negative regulation of striated muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] +synonym: "down regulation of striated muscle contraction" EXACT [] +synonym: "down-regulation of striated muscle contraction" EXACT [] +synonym: "downregulation of striated muscle contraction" EXACT [] +synonym: "inhibition of striated muscle contraction" NARROW [] +is_a: GO:0006942 ! regulation of striated muscle contraction +is_a: GO:0045932 ! negative regulation of muscle contraction +relationship: negatively_regulates GO:0006941 ! striated muscle contraction + +[Term] +id: GO:0045989 +name: positive regulation of striated muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] +synonym: "activation of striated muscle contraction" NARROW [] +synonym: "stimulation of striated muscle contraction" NARROW [] +synonym: "up regulation of striated muscle contraction" EXACT [] +synonym: "up-regulation of striated muscle contraction" EXACT [] +synonym: "upregulation of striated muscle contraction" EXACT [] +is_a: GO:0006942 ! regulation of striated muscle contraction +is_a: GO:0045933 ! positive regulation of muscle contraction +relationship: positively_regulates GO:0006941 ! striated muscle contraction + +[Term] +id: GO:0045990 +name: regulation of transcription by carbon catabolites +namespace: biological_process +def: "Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0031670 ! cellular response to nutrient + +[Term] +id: GO:0045991 +name: positive regulation of transcription by carbon catabolites +namespace: biological_process +def: "Any process involving carbon catabolites that activates or increases the rate of transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of transcription by carbon catabolites" NARROW [] +synonym: "stimulation of transcription by carbon catabolites" NARROW [] +synonym: "up regulation of transcription by carbon catabolites" EXACT [] +synonym: "up-regulation of transcription by carbon catabolites" EXACT [] +synonym: "upregulation of transcription by carbon catabolites" EXACT [] +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +is_a: GO:0045990 ! regulation of transcription by carbon catabolites + +[Term] +id: GO:0045992 +name: negative regulation of embryonic development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] +synonym: "down regulation of embryonic development" EXACT [] +synonym: "down-regulation of embryonic development" EXACT [] +synonym: "downregulation of embryonic development" EXACT [] +synonym: "inhibition of embryonic development" NARROW [] +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0009790 ! embryonic development + +[Term] +id: GO:0045993 +name: negative regulation of translational initiation by iron +namespace: biological_process +def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of translational initiation by iron" EXACT [] +synonym: "down-regulation of translational initiation by iron" EXACT [] +synonym: "downregulation of translational initiation by iron" EXACT [] +synonym: "inhibition of translational initiation by iron" NARROW [] +is_a: GO:0006447 ! regulation of translational initiation by iron +is_a: GO:0045947 ! negative regulation of translational initiation + +[Term] +id: GO:0045994 +name: positive regulation of translational initiation by iron +namespace: biological_process +def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of translational initiation by iron" NARROW [] +synonym: "stimulation of translational initiation by iron" NARROW [] +synonym: "up regulation of translational initiation by iron" EXACT [] +synonym: "up-regulation of translational initiation by iron" EXACT [] +synonym: "upregulation of translational initiation by iron" EXACT [] +is_a: GO:0006447 ! regulation of translational initiation by iron +is_a: GO:0045948 ! positive regulation of translational initiation + +[Term] +id: GO:0045995 +name: regulation of embryonic development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009790 ! embryonic development + +[Term] +id: GO:0045996 +name: negative regulation of transcription by pheromones +namespace: biological_process +def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "down regulation of transcription by pheromones" EXACT [] +synonym: "down-regulation of transcription by pheromones" EXACT [] +synonym: "downregulation of transcription by pheromones" EXACT [] +synonym: "inhibition of transcription by pheromones" NARROW [] +is_a: GO:0009373 ! regulation of transcription by pheromones +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent + +[Term] +id: GO:0045997 +name: negative regulation of ecdysteroid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] +synonym: "down regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "downregulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "inhibition of ecdysteroid biosynthetic process" NARROW [] +synonym: "negative regulation of ecdysteroid anabolism" EXACT [] +synonym: "negative regulation of ecdysteroid biosynthesis" EXACT [] +synonym: "negative regulation of ecdysteroid formation" EXACT [] +synonym: "negative regulation of ecdysteroid synthesis" EXACT [] +is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0045998 +name: positive regulation of ecdysteroid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] +synonym: "activation of ecdysteroid biosynthetic process" NARROW [] +synonym: "positive regulation of ecdysteroid anabolism" EXACT [] +synonym: "positive regulation of ecdysteroid biosynthesis" EXACT [] +synonym: "positive regulation of ecdysteroid formation" EXACT [] +synonym: "positive regulation of ecdysteroid synthesis" EXACT [] +synonym: "stimulation of ecdysteroid biosynthetic process" NARROW [] +synonym: "up regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "upregulation of ecdysteroid biosynthetic process" EXACT [] +is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process +is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0045999 +name: negative regulation of ecdysteroid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] +synonym: "down regulation of ecdysteroid secretion" EXACT [] +synonym: "down-regulation of ecdysteroid secretion" EXACT [] +synonym: "downregulation of ecdysteroid secretion" EXACT [] +synonym: "inhibition of ecdysteroid secretion" NARROW [] +is_a: GO:0007555 ! regulation of ecdysteroid secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion + +[Term] +id: GO:0046000 +name: positive regulation of ecdysteroid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] +synonym: "activation of ecdysteroid secretion" NARROW [] +synonym: "stimulation of ecdysteroid secretion" NARROW [] +synonym: "up regulation of ecdysteroid secretion" EXACT [] +synonym: "up-regulation of ecdysteroid secretion" EXACT [] +synonym: "upregulation of ecdysteroid secretion" EXACT [] +is_a: GO:0007555 ! regulation of ecdysteroid secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0045457 ! ecdysteroid secretion + +[Term] +id: GO:0046001 +name: negative regulation of preblastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW [] +synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle +is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic +relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle + +[Term] +id: GO:0046002 +name: positive regulation of preblastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW [] +synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW [] +synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT [] +is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle +is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic +relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle + +[Term] +id: GO:0046003 +name: negative regulation of syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW [] +synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT [] +is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle +is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic +relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle + +[Term] +id: GO:0046004 +name: positive regulation of syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] +synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] +synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle +is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic +relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle + +[Term] +id: GO:0046005 +name: positive regulation of circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators] +synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW [] +synonym: "positive regulation of REM sleep" EXACT [] +synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW [] +synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT [] +is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep +is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep +relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep + +[Term] +id: GO:0046006 +name: regulation of activated T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators] +synonym: "regulation of activated T lymphocyte proliferation" EXACT [] +synonym: "regulation of activated T-cell proliferation" EXACT [] +synonym: "regulation of activated T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +relationship: regulates GO:0050798 ! activated T cell proliferation + +[Term] +id: GO:0046007 +name: negative regulation of activated T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators] +synonym: "down regulation of activated T cell proliferation" EXACT [] +synonym: "down-regulation of activated T cell proliferation" EXACT [] +synonym: "downregulation of activated T cell proliferation" EXACT [] +synonym: "inhibition of activated T cell proliferation" NARROW [] +synonym: "negative regulation of activated T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of activated T-cell proliferation" EXACT [] +synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046006 ! regulation of activated T cell proliferation +relationship: negatively_regulates GO:0050798 ! activated T cell proliferation + +[Term] +id: GO:0046008 +name: regulation of female receptivity, post-mating +namespace: biological_process +def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] +is_a: GO:0045924 ! regulation of female receptivity +relationship: part_of GO:0045297 ! post-mating behavior + +[Term] +id: GO:0046009 +name: positive regulation of female receptivity, post-mating +namespace: biological_process +def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] +synonym: "activation of female receptivity, post-mating" NARROW [] +synonym: "stimulation of female receptivity, post-mating" NARROW [] +synonym: "up regulation of female receptivity, post-mating" EXACT [] +synonym: "up-regulation of female receptivity, post-mating" EXACT [] +synonym: "upregulation of female receptivity, post-mating" EXACT [] +is_a: GO:0045925 ! positive regulation of female receptivity +is_a: GO:0046008 ! regulation of female receptivity, post-mating + +[Term] +id: GO:0046010 +name: positive regulation of circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators] +synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW [] +synonym: "positive regulation of non-REM sleep" EXACT [] +synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW [] +synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep +is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep +relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep + +[Term] +id: GO:0046011 +name: regulation of oskar mRNA translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0046012 +name: positive regulation of oskar mRNA translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators] +synonym: "activation of oskar mRNA translation" NARROW [] +synonym: "stimulation of oskar mRNA translation" NARROW [] +synonym: "up regulation of oskar mRNA translation" EXACT [] +synonym: "up-regulation of oskar mRNA translation" EXACT [] +synonym: "upregulation of oskar mRNA translation" EXACT [] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0046011 ! regulation of oskar mRNA translation + +[Term] +id: GO:0046013 +name: regulation of T cell homeostatic proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators] +synonym: "regulation of resting T cell proliferation" EXACT [] +synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT [] +synonym: "regulation of T-cell homeostatic proliferation" EXACT [] +synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0042129 ! regulation of T cell proliferation +relationship: regulates GO:0001777 ! T cell homeostatic proliferation + +[Term] +id: GO:0046014 +name: negative regulation of T cell homeostatic proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators] +synonym: "down regulation of T cell homeostatic proliferation" EXACT [] +synonym: "down-regulation of T cell homeostatic proliferation" EXACT [] +synonym: "downregulation of T cell homeostatic proliferation" EXACT [] +synonym: "inhibition of T cell homeostatic proliferation" NARROW [] +synonym: "negative regulation of resting T cell proliferation" EXACT [] +synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT [] +synonym: "negative regulation of T-cell homeostatic proliferation" EXACT [] +synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046013 ! regulation of T cell homeostatic proliferation +relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation + +[Term] +id: GO:0046015 +name: regulation of transcription by glucose +namespace: biological_process +def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0045990 ! regulation of transcription by carbon catabolites + +[Term] +id: GO:0046016 +name: positive regulation of transcription by glucose +namespace: biological_process +def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators] +subset: gosubset_prok +synonym: "activation of transcription by glucose" NARROW [] +synonym: "stimulation of transcription by glucose" NARROW [] +synonym: "up regulation of transcription by glucose" EXACT [] +synonym: "up-regulation of transcription by glucose" EXACT [] +synonym: "upregulation of transcription by glucose" EXACT [] +is_a: GO:0045991 ! positive regulation of transcription by carbon catabolites +is_a: GO:0046015 ! regulation of transcription by glucose + +[Term] +id: GO:0046017 +name: regulation of transcription from RNA polymerase I promoter, mitotic +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] +synonym: "mitotic regulation of transcription from Pol I promoter" EXACT [] +synonym: "regulation of transcription from Pol I promoter, mitotic" EXACT [] +is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter +is_a: GO:0045896 ! regulation of transcription, mitotic + +[Term] +id: GO:0046018 +name: positive regulation of transcription from RNA polymerase I promoter, mitotic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase I promoter, mitotic" NARROW [] +synonym: "mitotic activation of transcription from Pol I promoter" EXACT [] +synonym: "positive regulation of transcription from Pol I promoter, mitotic" EXACT [] +synonym: "stimulation of transcription from RNA polymerase I promoter, mitotic" NARROW [] +synonym: "up regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] +synonym: "upregulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] +is_a: GO:0045897 ! positive regulation of transcription, mitotic +is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter +is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic + +[Term] +id: GO:0046019 +name: regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from the RNA polymerase II promoter." [GOC:go_curators] +synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT [] +is_a: GO:0009373 ! regulation of transcription by pheromones +is_a: GO:0010551 ! regulation of specific transcription from RNA polymerase II promoter + +[Term] +id: GO:0046020 +name: negative regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW [] +synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT [] +is_a: GO:0010553 ! negative regulation of specific transcription from RNA polymerase II promoter +is_a: GO:0045996 ! negative regulation of transcription by pheromones +is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones + +[Term] +id: GO:0046021 +name: regulation of transcription from RNA polymerase II promoter, mitotic +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] +synonym: "mitotic regulation of transcription from Pol II promoter" EXACT [] +synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0045896 ! regulation of transcription, mitotic + +[Term] +id: GO:0046022 +name: positive regulation of transcription from RNA polymerase II promoter, mitotic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase II promoter, mitotic" NARROW [] +synonym: "mitotic activation of transcription from Pol II promoter" EXACT [] +synonym: "positive regulation of transcription from Pol II promoter, mitotic" EXACT [] +synonym: "stimulation of transcription from RNA polymerase II promoter, mitotic" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] +is_a: GO:0045897 ! positive regulation of transcription, mitotic +is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter +is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic + +[Term] +id: GO:0046023 +name: regulation of transcription from RNA polymerase III promoter, mitotic +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] +synonym: "mitotic regulation of transcription from Pol III promoter" EXACT [] +synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT [] +is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter +is_a: GO:0045896 ! regulation of transcription, mitotic + +[Term] +id: GO:0046024 +name: positive regulation of transcription from RNA polymerase III promoter, mitotic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase III promoter, mitotic" NARROW [] +synonym: "mitotic activation of transcription from Pol III promoter" EXACT [] +synonym: "positive regulation of transcription from Pol III promoter, mitotic" EXACT [] +synonym: "stimulation of transcription from RNA polymerase III promoter, mitotic" NARROW [] +synonym: "up regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] +synonym: "upregulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] +is_a: GO:0045897 ! positive regulation of transcription, mitotic +is_a: GO:0045945 ! positive regulation of transcription from RNA polymerase III promoter +is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic + +[Term] +id: GO:0046025 +name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132] +subset: gosubset_prok +synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132] +synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132] +synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" EXACT [EC:2.1.1.132] +xref: EC:2.1.1.132 +xref: MetaCyc:2.1.1.132-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046026 +name: precorrin-4 C11-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133] +subset: gosubset_prok +synonym: "CobM" RELATED [EC:2.1.1.133] +synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" EXACT [EC:2.1.1.133] +xref: EC:2.1.1.133 +xref: MetaCyc:2.1.1.133-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046027 +name: phospholipid:diacylglycerol acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158] +synonym: "PDAT activity" EXACT [EC:2.3.1.158] +synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158] +xref: EC:2.3.1.158 +xref: MetaCyc:2.3.1.158-RXN +xref: Reactome:22783 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0046028 +name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity +namespace: molecular_function +def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] +synonym: "plastocyanin" NARROW [] +is_a: GO:0009055 ! electron carrier activity + +[Term] +id: GO:0046029 +name: mannitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + NADH + H+." [EC:1.1.1.255] +synonym: "mannitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.255] +synonym: "MTD activity" EXACT [EC:1.1.1.255] +synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255] +xref: EC:1.1.1.255 +xref: MetaCyc:1.1.1.255-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0046030 +name: inositol trisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate." [GOC:bf] +synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW [] +synonym: "IP(3) phosphatase activity" EXACT [] +synonym: "IP3 phosphatase activity" EXACT [] +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0046031 +name: ADP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "ADP metabolism" EXACT [] +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046032 +name: ADP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "ADP breakdown" EXACT [] +synonym: "ADP catabolism" EXACT [] +synonym: "ADP degradation" EXACT [] +is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0046033 +name: AMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "adenylate forming enzyme activity" RELATED [] +synonym: "AMP metabolism" EXACT [] +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046034 +name: ATP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] +subset: gosubset_prok +synonym: "ATP metabolism" EXACT [] +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046035 +name: CMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "CMP metabolism" EXACT [] +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046036 +name: CTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "CTP metabolism" EXACT [] +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046037 +name: GMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "GMP metabolism" EXACT [] +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046038 +name: GMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "GMP breakdown" EXACT [] +synonym: "GMP catabolism" EXACT [] +synonym: "GMP degradation" EXACT [] +is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process +is_a: GO:0046037 ! GMP metabolic process + +[Term] +id: GO:0046039 +name: GTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "GTP metabolism" EXACT [] +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046040 +name: IMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "IMP metabolism" EXACT [] +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046041 +name: ITP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "ITP metabolism" EXACT [] +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046042 +name: ITP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "ITP anabolism" EXACT [] +synonym: "ITP biosynthesis" EXACT [] +synonym: "ITP formation" EXACT [] +synonym: "ITP synthesis" EXACT [] +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046041 ! ITP metabolic process + +[Term] +id: GO:0046043 +name: TDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "TDP metabolism" EXACT [] +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046044 +name: TMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "TMP metabolism" EXACT [] +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046045 +name: TMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "TMP breakdown" EXACT [] +synonym: "TMP catabolism" EXACT [] +synonym: "TMP degradation" EXACT [] +is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process +is_a: GO:0046044 ! TMP metabolic process + +[Term] +id: GO:0046046 +name: TTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "TTP metabolism" EXACT [] +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046047 +name: TTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "TTP breakdown" EXACT [] +synonym: "TTP catabolism" EXACT [] +synonym: "TTP degradation" EXACT [] +synonym: "TTP hydrolysis" EXACT [] +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0046046 ! TTP metabolic process + +[Term] +id: GO:0046048 +name: UDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "UDP metabolism" EXACT [] +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046049 +name: UMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "UMP metabolism" EXACT [] +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046050 +name: UMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "UMP breakdown" EXACT [] +synonym: "UMP catabolism" EXACT [] +synonym: "UMP degradation" EXACT [] +is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process +is_a: GO:0046049 ! UMP metabolic process + +[Term] +id: GO:0046051 +name: UTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "UTP metabolism" EXACT [] +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046052 +name: UTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "UTP breakdown" EXACT [] +synonym: "UTP catabolism" EXACT [] +synonym: "UTP degradation" EXACT [] +synonym: "UTP hydrolysis" EXACT [] +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0046051 ! UTP metabolic process + +[Term] +id: GO:0046053 +name: dAMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dAMP metabolism" EXACT [] +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046054 +name: dGMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dGMP metabolism" EXACT [] +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046055 +name: dGMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dGMP breakdown" EXACT [] +synonym: "dGMP catabolism" EXACT [] +synonym: "dGMP degradation" EXACT [] +is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046054 ! dGMP metabolic process + +[Term] +id: GO:0046056 +name: dADP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dADP metabolism" EXACT [] +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046057 +name: dADP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dADP breakdown" EXACT [] +synonym: "dADP catabolism" EXACT [] +synonym: "dADP degradation" EXACT [] +is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046056 ! dADP metabolic process + +[Term] +id: GO:0046058 +name: cAMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "3',5' cAMP metabolic process" EXACT [] +synonym: "3',5' cAMP metabolism" EXACT [] +synonym: "3',5'-cAMP metabolic process" EXACT [] +synonym: "3',5'-cAMP metabolism" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "cAMP generating peptide activity" RELATED [] +synonym: "cAMP metabolism" EXACT [] +synonym: "cyclic AMP metabolic process" EXACT [] +synonym: "cyclic AMP metabolism" EXACT [] +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0046059 +name: dAMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dAMP breakdown" EXACT [] +synonym: "dAMP catabolism" EXACT [] +synonym: "dAMP degradation" EXACT [] +is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046053 ! dAMP metabolic process + +[Term] +id: GO:0046060 +name: dATP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dATP metabolism" EXACT [] +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046061 +name: dATP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dATP breakdown" EXACT [] +synonym: "dATP catabolism" EXACT [] +synonym: "dATP degradation" EXACT [] +is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046060 ! dATP metabolic process + +[Term] +id: GO:0046062 +name: dCDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dCDP metabolism" EXACT [] +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046063 +name: dCMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dCMP metabolism" EXACT [] +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046064 +name: dCMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dCMP anabolism" EXACT [] +synonym: "dCMP biosynthesis" EXACT [] +synonym: "dCMP formation" EXACT [] +synonym: "dCMP synthesis" EXACT [] +is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046063 ! dCMP metabolic process + +[Term] +id: GO:0046065 +name: dCTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dCTP metabolism" EXACT [] +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046066 +name: dGDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dGDP metabolism" EXACT [] +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046067 +name: dGDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dGDP breakdown" EXACT [] +synonym: "dGDP catabolism" EXACT [] +synonym: "dGDP degradation" EXACT [] +is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046066 ! dGDP metabolic process + +[Term] +id: GO:0046068 +name: cGMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "cGMP metabolism" EXACT [] +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0046069 +name: cGMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "cGMP breakdown" EXACT [] +synonym: "cGMP catabolism" EXACT [] +synonym: "cGMP degradation" EXACT [] +is_a: GO:0009214 ! cyclic nucleotide catabolic process +is_a: GO:0046068 ! cGMP metabolic process + +[Term] +id: GO:0046070 +name: dGTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dGTP metabolism" EXACT [] +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046071 +name: dGTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dGTP anabolism" EXACT [] +synonym: "dGTP biosynthesis" EXACT [] +synonym: "dGTP formation" EXACT [] +synonym: "dGTP synthesis" EXACT [] +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046070 ! dGTP metabolic process + +[Term] +id: GO:0046072 +name: dTDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dTDP metabolism" EXACT [] +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046073 +name: dTMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dTMP metabolism" EXACT [] +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046074 +name: dTMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dTMP breakdown" EXACT [] +synonym: "dTMP catabolism" EXACT [] +synonym: "dTMP degradation" EXACT [] +is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046073 ! dTMP metabolic process + +[Term] +id: GO:0046075 +name: dTTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dTTP metabolism" EXACT [] +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046076 +name: dTTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dTTP breakdown" EXACT [] +synonym: "dTTP catabolism" EXACT [] +synonym: "dTTP degradation" EXACT [] +is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046075 ! dTTP metabolic process + +[Term] +id: GO:0046077 +name: dUDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dUDP metabolism" EXACT [] +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046078 +name: dUMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators] +subset: gosubset_prok +synonym: "dUMP metabolism" EXACT [] +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046079 +name: dUMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dUMP breakdown" EXACT [] +synonym: "dUMP catabolism" EXACT [] +synonym: "dUMP degradation" EXACT [] +is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046078 ! dUMP metabolic process + +[Term] +id: GO:0046080 +name: dUTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dUTP metabolism" EXACT [] +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046081 +name: dUTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] +subset: gosubset_prok +synonym: "dUTP breakdown" EXACT [] +synonym: "dUTP catabolism" EXACT [] +synonym: "dUTP degradation" EXACT [] +is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046080 ! dUTP metabolic process + +[Term] +id: GO:0046082 +name: 5-methylcytosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "5-methylcytosine anabolism" EXACT [] +synonym: "5-methylcytosine biosynthesis" EXACT [] +synonym: "5-methylcytosine formation" EXACT [] +synonym: "5-methylcytosine synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine base biosynthetic process +is_a: GO:0019857 ! 5-methylcytosine metabolic process + +[Term] +id: GO:0046083 +name: adenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] +subset: gosubset_prok +synonym: "adenine metabolism" EXACT [] +is_a: GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0046084 +name: adenine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] +subset: gosubset_prok +synonym: "adenine anabolism" EXACT [] +synonym: "adenine biosynthesis" EXACT [] +synonym: "adenine formation" EXACT [] +synonym: "adenine synthesis" EXACT [] +is_a: GO:0009113 ! purine base biosynthetic process +is_a: GO:0046083 ! adenine metabolic process + +[Term] +id: GO:0046085 +name: adenosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] +subset: gosubset_prok +synonym: "adenosine metabolism" EXACT [] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046086 +name: adenosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] +subset: gosubset_prok +synonym: "adenosine anabolism" EXACT [] +synonym: "adenosine biosynthesis" EXACT [] +synonym: "adenosine formation" EXACT [] +synonym: "adenosine synthesis" EXACT [] +is_a: GO:0046085 ! adenosine metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0046087 +name: cytidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] +subset: gosubset_prok +synonym: "cytidine metabolism" EXACT [] +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process + +[Term] +id: GO:0046088 +name: cytidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] +subset: gosubset_prok +synonym: "cytidine anabolism" EXACT [] +synonym: "cytidine biosynthesis" EXACT [] +synonym: "cytidine formation" EXACT [] +synonym: "cytidine synthesis" EXACT [] +is_a: GO:0046087 ! cytidine metabolic process +is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process + +[Term] +id: GO:0046089 +name: cytosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] +subset: gosubset_prok +synonym: "cytosine anabolism" EXACT [] +synonym: "cytosine biosynthesis" EXACT [] +synonym: "cytosine formation" EXACT [] +synonym: "cytosine synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine base biosynthetic process +is_a: GO:0019858 ! cytosine metabolic process + +[Term] +id: GO:0046090 +name: deoxyadenosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyadenosine metabolism" EXACT [] +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046091 +name: deoxyadenosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyadenosine anabolism" EXACT [] +synonym: "deoxyadenosine biosynthesis" EXACT [] +synonym: "deoxyadenosine formation" EXACT [] +synonym: "deoxyadenosine synthesis" EXACT [] +is_a: GO:0046090 ! deoxyadenosine metabolic process +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046092 +name: deoxycytidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxycytidine metabolism" EXACT [] +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046093 +name: deoxycytidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxycytidine anabolism" EXACT [] +synonym: "deoxycytidine biosynthesis" EXACT [] +synonym: "deoxycytidine formation" EXACT [] +synonym: "deoxycytidine synthesis" EXACT [] +is_a: GO:0046092 ! deoxycytidine metabolic process +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046094 +name: deoxyinosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyinosine metabolism" EXACT [] +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046095 +name: deoxyinosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyinosine anabolism" EXACT [] +synonym: "deoxyinosine biosynthesis" EXACT [] +synonym: "deoxyinosine formation" EXACT [] +synonym: "deoxyinosine synthesis" EXACT [] +is_a: GO:0046094 ! deoxyinosine metabolic process +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046096 +name: deoxyuridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyuridine metabolism" EXACT [] +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046097 +name: deoxyuridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyuridine anabolism" EXACT [] +synonym: "deoxyuridine biosynthesis" EXACT [] +synonym: "deoxyuridine formation" EXACT [] +synonym: "deoxyuridine synthesis" EXACT [] +is_a: GO:0046096 ! deoxyuridine metabolic process +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046098 +name: guanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] +subset: gosubset_prok +synonym: "guanine metabolism" EXACT [] +is_a: GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0046099 +name: guanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] +subset: gosubset_prok +synonym: "guanine anabolism" EXACT [] +synonym: "guanine biosynthesis" EXACT [] +synonym: "guanine formation" EXACT [] +synonym: "guanine synthesis" EXACT [] +is_a: GO:0009113 ! purine base biosynthetic process +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0046100 +name: hypoxanthine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] +subset: gosubset_prok +synonym: "hypoxanthine metabolism" EXACT [] +is_a: GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0046101 +name: hypoxanthine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] +subset: gosubset_prok +synonym: "hypoxanthine anabolism" EXACT [] +synonym: "hypoxanthine biosynthesis" EXACT [] +synonym: "hypoxanthine formation" EXACT [] +synonym: "hypoxanthine synthesis" EXACT [] +is_a: GO:0009113 ! purine base biosynthetic process +is_a: GO:0046100 ! hypoxanthine metabolic process + +[Term] +id: GO:0046102 +name: inosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] +subset: gosubset_prok +synonym: "inosine metabolism" EXACT [] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046103 +name: inosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] +subset: gosubset_prok +synonym: "inosine anabolism" EXACT [] +synonym: "inosine biosynthesis" EXACT [] +synonym: "inosine formation" EXACT [] +synonym: "inosine synthesis" EXACT [] +is_a: GO:0046102 ! inosine metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0046104 +name: thymidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyribosylthymine metabolic process" EXACT [] +synonym: "deoxyribosylthymine metabolism" EXACT [] +synonym: "thymidine metabolism" EXACT [] +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046105 +name: thymidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "deoxyribosylthymine biosynthesis" EXACT [] +synonym: "deoxyribosylthymine biosynthetic process" EXACT [] +synonym: "thymidine anabolism" EXACT [] +synonym: "thymidine biosynthesis" EXACT [] +synonym: "thymidine formation" EXACT [] +synonym: "thymidine synthesis" EXACT [] +is_a: GO:0046104 ! thymidine metabolic process +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046106 +name: thymine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] +subset: gosubset_prok +synonym: "thymine anabolism" EXACT [] +synonym: "thymine biosynthesis" EXACT [] +synonym: "thymine formation" EXACT [] +synonym: "thymine synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine base biosynthetic process +is_a: GO:0019859 ! thymine metabolic process + +[Term] +id: GO:0046107 +name: uracil biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] +subset: gosubset_prok +synonym: "uracil anabolism" EXACT [] +synonym: "uracil biosynthesis" EXACT [] +synonym: "uracil formation" EXACT [] +synonym: "uracil synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine base biosynthetic process +is_a: GO:0019860 ! uracil metabolic process + +[Term] +id: GO:0046108 +name: uridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "uridine metabolism" EXACT [] +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process + +[Term] +id: GO:0046109 +name: uridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "uridine anabolism" EXACT [] +synonym: "uridine biosynthesis" EXACT [] +synonym: "uridine formation" EXACT [] +synonym: "uridine synthesis" EXACT [] +is_a: GO:0046108 ! uridine metabolic process +is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process + +[Term] +id: GO:0046110 +name: xanthine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "xanthine metabolism" EXACT [] +is_a: GO:0006144 ! purine base metabolic process + +[Term] +id: GO:0046111 +name: xanthine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] +subset: gosubset_prok +synonym: "xanthine anabolism" EXACT [] +synonym: "xanthine biosynthesis" EXACT [] +synonym: "xanthine formation" EXACT [] +synonym: "xanthine synthesis" EXACT [] +is_a: GO:0009113 ! purine base biosynthetic process +is_a: GO:0046110 ! xanthine metabolic process + +[Term] +id: GO:0046112 +name: nucleobase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] +subset: gosubset_prok +synonym: "nucleobase anabolism" EXACT [] +synonym: "nucleobase biosynthesis" EXACT [] +synonym: "nucleobase formation" EXACT [] +synonym: "nucleobase synthesis" EXACT [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process + +[Term] +id: GO:0046113 +name: nucleobase catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] +subset: gosubset_prok +synonym: "nucleobase breakdown" EXACT [] +synonym: "nucleobase catabolism" EXACT [] +synonym: "nucleobase degradation" EXACT [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process + +[Term] +id: GO:0046114 +name: guanosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] +subset: gosubset_prok +synonym: "guanosine anabolism" EXACT [] +synonym: "guanosine biosynthesis" EXACT [] +synonym: "guanosine formation" EXACT [] +synonym: "guanosine synthesis" EXACT [] +is_a: GO:0008617 ! guanosine metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0046115 +name: guanosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] +subset: gosubset_prok +synonym: "guanosine breakdown" EXACT [] +synonym: "guanosine catabolism" EXACT [] +synonym: "guanosine degradation" EXACT [] +is_a: GO:0008617 ! guanosine metabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process + +[Term] +id: GO:0046116 +name: queuosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "queuosine metabolism" EXACT [] +is_a: GO:0008618 ! 7-methylguanosine metabolic process + +[Term] +id: GO:0046117 +name: queuosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "queuosine breakdown" EXACT [] +synonym: "queuosine catabolism" EXACT [] +synonym: "queuosine degradation" EXACT [] +is_a: GO:0046116 ! queuosine metabolic process +is_a: GO:0046119 ! 7-methylguanosine catabolic process + +[Term] +id: GO:0046118 +name: 7-methylguanosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "7-methylguanosine anabolism" EXACT [] +synonym: "7-methylguanosine biosynthesis" EXACT [] +synonym: "7-methylguanosine formation" EXACT [] +synonym: "7-methylguanosine synthesis" EXACT [] +is_a: GO:0008618 ! 7-methylguanosine metabolic process +is_a: GO:0046114 ! guanosine biosynthetic process + +[Term] +id: GO:0046119 +name: 7-methylguanosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "7-methylguanosine breakdown" EXACT [] +synonym: "7-methylguanosine catabolism" EXACT [] +synonym: "7-methylguanosine degradation" EXACT [] +is_a: GO:0008618 ! 7-methylguanosine metabolic process +is_a: GO:0046115 ! guanosine catabolic process + +[Term] +id: GO:0046120 +name: deoxyribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribonucleoside anabolism" EXACT [] +synonym: "deoxyribonucleoside biosynthesis" EXACT [] +synonym: "deoxyribonucleoside formation" EXACT [] +synonym: "deoxyribonucleoside synthesis" EXACT [] +is_a: GO:0009120 ! deoxyribonucleoside metabolic process +is_a: GO:0009163 ! nucleoside biosynthetic process + +[Term] +id: GO:0046121 +name: deoxyribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribonucleoside breakdown" EXACT [] +synonym: "deoxyribonucleoside catabolism" EXACT [] +synonym: "deoxyribonucleoside degradation" EXACT [] +is_a: GO:0009120 ! deoxyribonucleoside metabolic process +is_a: GO:0009164 ! nucleoside catabolic process + +[Term] +id: GO:0046122 +name: purine deoxyribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside metabolism" EXACT [] +is_a: GO:0009120 ! deoxyribonucleoside metabolic process +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0046123 +name: purine deoxyribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside anabolism" EXACT [] +synonym: "purine deoxyribonucleoside biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside formation" EXACT [] +synonym: "purine deoxyribonucleoside synthesis" EXACT [] +is_a: GO:0042451 ! purine nucleoside biosynthetic process +is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046124 +name: purine deoxyribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "purine deoxyribonucleoside breakdown" EXACT [] +synonym: "purine deoxyribonucleoside catabolism" EXACT [] +synonym: "purine deoxyribonucleoside degradation" EXACT [] +is_a: GO:0006152 ! purine nucleoside catabolic process +is_a: GO:0046121 ! deoxyribonucleoside catabolic process +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046125 +name: pyrimidine deoxyribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009120 ! deoxyribonucleoside metabolic process + +[Term] +id: GO:0046126 +name: pyrimidine deoxyribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT [] +is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process +is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process + +[Term] +id: GO:0046127 +name: pyrimidine deoxyribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside degradation" EXACT [] +is_a: GO:0046121 ! deoxyribonucleoside catabolic process +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process +is_a: GO:0046135 ! pyrimidine nucleoside catabolic process + +[Term] +id: GO:0046128 +name: purine ribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +subset: gosubset_prok +synonym: "purine ribonucleoside metabolism" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0046129 +name: purine ribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +subset: gosubset_prok +synonym: "purine ribonucleoside anabolism" EXACT [] +synonym: "purine ribonucleoside biosynthesis" EXACT [] +synonym: "purine ribonucleoside formation" EXACT [] +synonym: "purine ribonucleoside synthesis" EXACT [] +is_a: GO:0042451 ! purine nucleoside biosynthetic process +is_a: GO:0042455 ! ribonucleoside biosynthetic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046130 +name: purine ribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +subset: gosubset_prok +synonym: "purine ribonucleoside breakdown" EXACT [] +synonym: "purine ribonucleoside catabolism" EXACT [] +synonym: "purine ribonucleoside degradation" EXACT [] +is_a: GO:0006152 ! purine nucleoside catabolic process +is_a: GO:0042454 ! ribonucleoside catabolic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046131 +name: pyrimidine ribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside metabolism" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009119 ! ribonucleoside metabolic process + +[Term] +id: GO:0046132 +name: pyrimidine ribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside formation" EXACT [] +synonym: "pyrimidine ribonucleoside synthesis" EXACT [] +is_a: GO:0042455 ! ribonucleoside biosynthetic process +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process +is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process + +[Term] +id: GO:0046133 +name: pyrimidine ribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine ribonucleoside breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside degradation" EXACT [] +is_a: GO:0042454 ! ribonucleoside catabolic process +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process +is_a: GO:0046135 ! pyrimidine nucleoside catabolic process + +[Term] +id: GO:0046134 +name: pyrimidine nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine nucleoside anabolism" EXACT [] +synonym: "pyrimidine nucleoside biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside formation" EXACT [] +synonym: "pyrimidine nucleoside synthesis" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009163 ! nucleoside biosynthetic process + +[Term] +id: GO:0046135 +name: pyrimidine nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] +subset: gosubset_prok +synonym: "pyrimidine nucleoside breakdown" EXACT [] +synonym: "pyrimidine nucleoside catabolism" EXACT [] +synonym: "pyrimidine nucleoside degradation" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009164 ! nucleoside catabolic process + +[Term] +id: GO:0046136 +name: positive regulation of vitamin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: gosubset_prok +synonym: "activation of vitamin metabolic process" NARROW [] +synonym: "positive regulation of vitamin metabolism" EXACT [] +synonym: "stimulation of vitamin metabolic process" NARROW [] +synonym: "up regulation of vitamin metabolic process" EXACT [] +synonym: "up-regulation of vitamin metabolic process" EXACT [] +synonym: "upregulation of vitamin metabolic process" EXACT [] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +relationship: positively_regulates GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0046137 +name: negative regulation of vitamin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of vitamin metabolic process" EXACT [] +synonym: "down-regulation of vitamin metabolic process" EXACT [] +synonym: "downregulation of vitamin metabolic process" EXACT [] +synonym: "inhibition of vitamin metabolic process" NARROW [] +synonym: "negative regulation of vitamin metabolism" EXACT [] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +relationship: negatively_regulates GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0046138 +name: coenzyme and prosthetic group biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "coenzyme and prosthetic group anabolism" EXACT [] +synonym: "coenzyme and prosthetic group biosynthesis" EXACT [] +synonym: "coenzyme and prosthetic group formation" EXACT [] +synonym: "coenzyme and prosthetic group synthesis" EXACT [] +is_obsolete: true +consider: GO:0009108 +consider: GO:0051191 + +[Term] +id: GO:0046139 +name: coenzyme and prosthetic group catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "coenzyme and prosthetic group breakdown" EXACT [] +synonym: "coenzyme and prosthetic group catabolism" EXACT [] +synonym: "coenzyme and prosthetic group degradation" EXACT [] +is_obsolete: true +consider: GO:0009109 +consider: GO:0051190 + +[Term] +id: GO:0046140 +name: corrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] +subset: gosubset_prok +synonym: "corrin anabolism" EXACT [] +synonym: "corrin biosynthesis" EXACT [] +synonym: "corrin formation" EXACT [] +synonym: "corrin synthesis" EXACT [] +is_a: GO:0015009 ! corrin metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process +is_a: GO:0051188 ! cofactor biosynthetic process + +[Term] +id: GO:0046141 +name: corrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] +subset: gosubset_prok +synonym: "corrin breakdown" EXACT [] +synonym: "corrin catabolism" EXACT [] +synonym: "corrin degradation" EXACT [] +is_a: GO:0015009 ! corrin metabolic process +is_a: GO:0033015 ! tetrapyrrole catabolic process +is_a: GO:0051187 ! cofactor catabolic process + +[Term] +id: GO:0046142 +name: negative regulation of coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +is_obsolete: true +consider: GO:0051198 +consider: GO:0051201 + +[Term] +id: GO:0046143 +name: positive regulation of coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +is_obsolete: true +consider: GO:0051197 +consider: GO:0051200 + +[Term] +id: GO:0046144 +name: D-alanine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai] +subset: gosubset_prok +synonym: "D-alanine family amino acid metabolism" EXACT [] +is_a: GO:0006522 ! alanine metabolic process + +[Term] +id: GO:0046145 +name: D-alanine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai] +subset: gosubset_prok +synonym: "D-alanine family amino acid anabolism" EXACT [] +synonym: "D-alanine family amino acid biosynthesis" EXACT [] +synonym: "D-alanine family amino acid formation" EXACT [] +synonym: "D-alanine family amino acid synthesis" EXACT [] +is_a: GO:0006523 ! alanine biosynthetic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process + +[Term] +id: GO:0046146 +name: tetrahydrobiopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tetrahydrobiopterin metabolism" EXACT [] +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0046147 +name: tetrahydrobiopterin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tetrahydrobiopterin breakdown" EXACT [] +synonym: "tetrahydrobiopterin catabolism" EXACT [] +synonym: "tetrahydrobiopterin degradation" EXACT [] +is_a: GO:0042560 ! pteridine and derivative catabolic process +is_a: GO:0046146 ! tetrahydrobiopterin metabolic process + +[Term] +id: GO:0046148 +name: pigment biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pigment anabolism" EXACT [] +synonym: "pigment biosynthesis" EXACT [] +synonym: "pigment formation" EXACT [] +synonym: "pigment synthesis" EXACT [] +is_a: GO:0042440 ! pigment metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046149 +name: pigment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "pigment breakdown" EXACT [] +synonym: "pigment catabolism" EXACT [] +synonym: "pigment degradation" EXACT [] +is_a: GO:0042440 ! pigment metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0046150 +name: melanin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "melanin breakdown" EXACT [] +synonym: "melanin catabolism" EXACT [] +synonym: "melanin degradation" EXACT [] +is_a: GO:0006582 ! melanin metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0046151 +name: eye pigment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] +synonym: "eye pigment breakdown" EXACT [] +synonym: "eye pigment catabolism" EXACT [] +synonym: "eye pigment degradation" EXACT [] +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0046152 +name: ommochrome metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ommochrome metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0046158 ! ocellus pigment metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046153 +name: ommochrome catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "ommochrome breakdown" EXACT [] +synonym: "ommochrome catabolism" EXACT [] +synonym: "ommochrome degradation" EXACT [] +is_a: GO:0046151 ! eye pigment catabolic process +is_a: GO:0046152 ! ommochrome metabolic process +is_a: GO:0046159 ! ocellus pigment catabolic process + +[Term] +id: GO:0046154 +name: rhodopsin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "rhodopsin metabolism" EXACT [] +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0046155 +name: rhodopsin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "rhodopsin breakdown" EXACT [] +synonym: "rhodopsin catabolism" EXACT [] +synonym: "rhodopsin degradation" EXACT [] +is_a: GO:0044257 ! cellular protein catabolic process +is_a: GO:0046151 ! eye pigment catabolic process +is_a: GO:0046154 ! rhodopsin metabolic process + +[Term] +id: GO:0046156 +name: siroheme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sirohaem metabolic process" EXACT [] +synonym: "sirohaem metabolism" EXACT [] +synonym: "siroheme metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046157 +name: siroheme catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sirohaem catabolic process" EXACT [] +synonym: "sirohaem catabolism" EXACT [] +synonym: "siroheme breakdown" EXACT [] +synonym: "siroheme catabolism" EXACT [] +synonym: "siroheme degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046156 ! siroheme metabolic process + +[Term] +id: GO:0046158 +name: ocellus pigment metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "ocellus pigment metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042440 ! pigment metabolic process +relationship: part_of GO:0033060 ! ocellus pigmentation + +[Term] +id: GO:0046159 +name: ocellus pigment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "ocellus pigment breakdown" EXACT [] +synonym: "ocellus pigment catabolism" EXACT [] +synonym: "ocellus pigment degradation" EXACT [] +is_a: GO:0046149 ! pigment catabolic process +is_a: GO:0046158 ! ocellus pigment metabolic process + +[Term] +id: GO:0046160 +name: heme a metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "haem a metabolic process" EXACT [] +synonym: "haem a metabolism" EXACT [] +synonym: "heme a metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046161 +name: heme a catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "haem a catabolic process" EXACT [] +synonym: "haem a catabolism" EXACT [] +synonym: "heme a breakdown" EXACT [] +synonym: "heme a catabolism" EXACT [] +synonym: "heme a degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046160 ! heme a metabolic process + +[Term] +id: GO:0046162 +name: heme c metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "haem c metabolic process" EXACT [] +synonym: "haem c metabolism" EXACT [] +synonym: "heme c metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046163 +name: heme c catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "haem c catabolic process" EXACT [] +synonym: "haem c catabolism" EXACT [] +synonym: "heme c breakdown" EXACT [] +synonym: "heme c catabolism" EXACT [] +synonym: "heme c degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046162 ! heme c metabolic process + +[Term] +id: GO:0046164 +name: alcohol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ChEBI:30879, GOC:ai] +subset: gosubset_prok +synonym: "alcohol breakdown" EXACT [] +synonym: "alcohol catabolism" EXACT [] +synonym: "alcohol degradation" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0046165 +name: alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ChEBI:30879, GOC:ai] +subset: gosubset_prok +synonym: "alcohol anabolism" EXACT [] +synonym: "alcohol biosynthesis" EXACT [] +synonym: "alcohol formation" EXACT [] +synonym: "alcohol synthesis" EXACT [] +is_a: GO:0006066 ! cellular alcohol metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046166 +name: glyceraldehyde-3-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai] +subset: gosubset_prok +synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT [] +synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT [] +synonym: "glyceraldehyde-3-phosphate anabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT [] +synonym: "glyceraldehyde-3-phosphate formation" EXACT [] +synonym: "glyceraldehyde-3-phosphate synthesis" EXACT [] +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process + +[Term] +id: GO:0046167 +name: glycerol-3-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] +subset: gosubset_prok +synonym: "glycerol-3-phosphate anabolism" EXACT [] +synonym: "glycerol-3-phosphate biosynthesis" EXACT [] +synonym: "glycerol-3-phosphate formation" EXACT [] +synonym: "glycerol-3-phosphate synthesis" EXACT [] +is_a: GO:0006072 ! glycerol-3-phosphate metabolic process +is_a: GO:0006114 ! glycerol biosynthetic process + +[Term] +id: GO:0046168 +name: glycerol-3-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] +subset: gosubset_prok +synonym: "glycerol-3-phosphate breakdown" EXACT [] +synonym: "glycerol-3-phosphate catabolism" EXACT [] +synonym: "glycerol-3-phosphate degradation" EXACT [] +is_a: GO:0006072 ! glycerol-3-phosphate metabolic process +is_a: GO:0019563 ! glycerol catabolic process + +[Term] +id: GO:0046169 +name: methanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] +subset: gosubset_prok +synonym: "methanol anabolism" EXACT [] +synonym: "methanol biosynthesis" EXACT [] +synonym: "methanol formation" EXACT [] +synonym: "methanol synthesis" EXACT [] +is_a: GO:0015945 ! methanol metabolic process +is_a: GO:0019753 ! one-carbon compound biosynthetic process +is_a: GO:0034309 ! monohydric alcohol biosynthetic process + +[Term] +id: GO:0046170 +name: methanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] +subset: gosubset_prok +synonym: "methanol breakdown" EXACT [] +synonym: "methanol catabolism" EXACT [] +synonym: "methanol degradation" EXACT [] +is_a: GO:0015945 ! methanol metabolic process +is_a: GO:0019754 ! one-carbon compound catabolic process +is_a: GO:0034310 ! monohydric alcohol catabolic process + +[Term] +id: GO:0046171 +name: octanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] +subset: gosubset_prok +synonym: "octanol anabolism" EXACT [] +synonym: "octanol biosynthesis" EXACT [] +synonym: "octanol formation" EXACT [] +synonym: "octanol synthesis" EXACT [] +is_a: GO:0006070 ! octanol metabolic process +is_a: GO:0034309 ! monohydric alcohol biosynthetic process + +[Term] +id: GO:0046172 +name: octanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] +subset: gosubset_prok +synonym: "octanol breakdown" EXACT [] +synonym: "octanol catabolism" EXACT [] +synonym: "octanol degradation" EXACT [] +is_a: GO:0006070 ! octanol metabolic process +is_a: GO:0034310 ! monohydric alcohol catabolic process + +[Term] +id: GO:0046173 +name: polyol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [ChEBI:26191] +subset: gosubset_prok +synonym: "polyhydric alcohol biosynthetic process" EXACT [] +synonym: "polyol anabolism" EXACT [] +synonym: "polyol biosynthesis" EXACT [] +synonym: "polyol formation" EXACT [] +synonym: "polyol synthesis" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0046174 +name: polyol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [ChEBI:26191] +subset: gosubset_prok +synonym: "polyhydric alcohol catabolic process" EXACT [] +synonym: "polyol breakdown" EXACT [] +synonym: "polyol catabolism" EXACT [] +synonym: "polyol degradation" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0046175 +name: aldonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aldonic acid anabolism" EXACT [] +synonym: "aldonic acid biosynthesis" EXACT [] +synonym: "aldonic acid formation" EXACT [] +synonym: "aldonic acid synthesis" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0046176 +name: aldonic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "aldonic acid breakdown" EXACT [] +synonym: "aldonic acid catabolism" EXACT [] +synonym: "aldonic acid degradation" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0046177 +name: D-gluconate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-gluconate breakdown" EXACT [] +synonym: "D-gluconate catabolism" EXACT [] +synonym: "D-gluconate degradation" EXACT [] +xref: MetaCyc:GLUCONSUPER-PWY +is_a: GO:0019521 ! D-gluconate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0046178 +name: D-gluconate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-gluconate anabolism" EXACT [] +synonym: "D-gluconate biosynthesis" EXACT [] +synonym: "D-gluconate formation" EXACT [] +synonym: "D-gluconate synthesis" EXACT [] +is_a: GO:0019521 ! D-gluconate metabolic process +is_a: GO:0046175 ! aldonic acid biosynthetic process + +[Term] +id: GO:0046179 +name: D-dehydro-D-gluconate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-dehydro-D-gluconate anabolism" EXACT [] +synonym: "D-dehydro-D-gluconate biosynthesis" EXACT [] +synonym: "D-dehydro-D-gluconate formation" EXACT [] +synonym: "D-dehydro-D-gluconate synthesis" EXACT [] +is_a: GO:0019525 ! D-dehydro-D-gluconate metabolic process +is_a: GO:0046175 ! aldonic acid biosynthetic process + +[Term] +id: GO:0046180 +name: ketogluconate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ketogluconate anabolism" EXACT [] +synonym: "ketogluconate biosynthesis" EXACT [] +synonym: "ketogluconate formation" EXACT [] +synonym: "ketogluconate synthesis" EXACT [] +is_a: GO:0019522 ! ketogluconate metabolic process +is_a: GO:0046175 ! aldonic acid biosynthetic process + +[Term] +id: GO:0046181 +name: ketogluconate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ketogluconate breakdown" EXACT [] +synonym: "ketogluconate catabolism" EXACT [] +synonym: "ketogluconate degradation" EXACT [] +is_a: GO:0019522 ! ketogluconate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0046182 +name: L-idonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "L-idonate anabolism" EXACT [] +synonym: "L-idonate biosynthesis" EXACT [] +synonym: "L-idonate formation" EXACT [] +synonym: "L-idonate synthesis" EXACT [] +is_a: GO:0019523 ! L-idonate metabolic process +is_a: GO:0046180 ! ketogluconate biosynthetic process + +[Term] +id: GO:0046183 +name: L-idonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "L-idonate breakdown" EXACT [] +synonym: "L-idonate catabolism" EXACT [] +synonym: "L-idonate degradation" EXACT [] +is_a: GO:0019523 ! L-idonate metabolic process +is_a: GO:0046181 ! ketogluconate catabolic process + +[Term] +id: GO:0046184 +name: aldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] +subset: gosubset_prok +synonym: "aldehyde anabolism" EXACT [] +synonym: "aldehyde biosynthesis" EXACT [] +synonym: "aldehyde formation" EXACT [] +synonym: "aldehyde synthesis" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046185 +name: aldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] +subset: gosubset_prok +synonym: "aldehyde breakdown" EXACT [] +synonym: "aldehyde catabolism" EXACT [] +synonym: "aldehyde degradation" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0046186 +name: acetaldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] +subset: gosubset_prok +synonym: "acetaldehyde anabolism" EXACT [] +synonym: "acetaldehyde biosynthesis" EXACT [] +synonym: "acetaldehyde formation" EXACT [] +synonym: "acetaldehyde synthesis" EXACT [] +is_a: GO:0006117 ! acetaldehyde metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process + +[Term] +id: GO:0046187 +name: acetaldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] +subset: gosubset_prok +synonym: "acetaldehyde breakdown" EXACT [] +synonym: "acetaldehyde catabolism" EXACT [] +synonym: "acetaldehyde degradation" EXACT [] +is_a: GO:0006117 ! acetaldehyde metabolic process +is_a: GO:0046185 ! aldehyde catabolic process + +[Term] +id: GO:0046188 +name: methane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] +subset: gosubset_prok +synonym: "methane breakdown" EXACT [] +synonym: "methane catabolism" EXACT [] +synonym: "methane degradation" EXACT [] +is_a: GO:0015947 ! methane metabolic process +is_a: GO:0019754 ! one-carbon compound catabolic process +is_a: GO:0043448 ! alkane catabolic process + +[Term] +id: GO:0046189 +name: phenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers." [GOC:ai] +subset: gosubset_prok +synonym: "phenol anabolism" EXACT [] +synonym: "phenol biosynthesis" EXACT [] +synonym: "phenol formation" EXACT [] +synonym: "phenol synthesis" EXACT [] +is_a: GO:0018958 ! phenol metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0046190 +name: aerobic phenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "aerobic phenol anabolism" EXACT [] +synonym: "aerobic phenol biosynthesis" EXACT [] +synonym: "aerobic phenol formation" EXACT [] +synonym: "aerobic phenol synthesis" EXACT [] +is_a: GO:0018959 ! aerobic phenol metabolic process +is_a: GO:0046189 ! phenol biosynthetic process + +[Term] +id: GO:0046191 +name: aerobic phenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "aerobic phenol breakdown" EXACT [] +synonym: "aerobic phenol catabolism" EXACT [] +synonym: "aerobic phenol degradation" EXACT [] +is_a: GO:0018959 ! aerobic phenol metabolic process +is_a: GO:0019336 ! phenol catabolic process + +[Term] +id: GO:0046192 +name: anaerobic phenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic phenol anabolism" EXACT [] +synonym: "anaerobic phenol biosynthesis" EXACT [] +synonym: "anaerobic phenol formation" EXACT [] +synonym: "anaerobic phenol synthesis" EXACT [] +is_a: GO:0042215 ! anaerobic phenol metabolic process +is_a: GO:0046189 ! phenol biosynthetic process + +[Term] +id: GO:0046193 +name: anaerobic phenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic phenol breakdown" EXACT [] +synonym: "anaerobic phenol catabolism" EXACT [] +synonym: "anaerobic phenol degradation" EXACT [] +is_a: GO:0019336 ! phenol catabolic process +is_a: GO:0042215 ! anaerobic phenol metabolic process + +[Term] +id: GO:0046194 +name: pentachlorophenol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai] +comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "pentachlorophenol anabolism" EXACT [] +synonym: "pentachlorophenol biosynthesis" EXACT [] +synonym: "pentachlorophenol formation" EXACT [] +synonym: "pentachlorophenol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018961 + +[Term] +id: GO:0046195 +name: 4-nitrophenol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] +comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "4-nitrophenol anabolism" EXACT [] +synonym: "4-nitrophenol biosynthesis" EXACT [] +synonym: "4-nitrophenol formation" EXACT [] +synonym: "4-nitrophenol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018960 + +[Term] +id: GO:0046196 +name: 4-nitrophenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] +subset: gosubset_prok +synonym: "4-nitrophenol breakdown" EXACT [] +synonym: "4-nitrophenol catabolism" EXACT [] +synonym: "4-nitrophenol degradation" EXACT [] +is_a: GO:0018960 ! 4-nitrophenol metabolic process +is_a: GO:0019336 ! phenol catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046197 +name: orcinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai] +subset: gosubset_prok +synonym: "orcinol anabolism" EXACT [] +synonym: "orcinol biosynthesis" EXACT [] +synonym: "orcinol formation" EXACT [] +synonym: "orcinol synthesis" EXACT [] +is_a: GO:0018940 ! orcinol metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0046198 +name: cresol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] +comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "cresol anabolism" EXACT [] +synonym: "cresol biosynthesis" EXACT [] +synonym: "cresol formation" EXACT [] +synonym: "cresol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0042212 + +[Term] +id: GO:0046199 +name: cresol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] +subset: gosubset_prok +synonym: "cresol breakdown" EXACT [] +synonym: "cresol catabolism" EXACT [] +synonym: "cresol degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042212 ! cresol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0046200 +name: m-cresol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai] +comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "m-cresol anabolism" EXACT [] +synonym: "m-cresol biosynthesis" EXACT [] +synonym: "m-cresol formation" EXACT [] +synonym: "m-cresol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018925 + +[Term] +id: GO:0046201 +name: cyanate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai] +subset: gosubset_prok +synonym: "cyanate anabolism" EXACT [] +synonym: "cyanate biosynthesis" EXACT [] +synonym: "cyanate formation" EXACT [] +synonym: "cyanate synthesis" EXACT [] +is_a: GO:0009439 ! cyanate metabolic process +is_a: GO:0019753 ! one-carbon compound biosynthetic process +is_a: GO:0044271 ! nitrogen compound biosynthetic process + +[Term] +id: GO:0046202 +name: cyanide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai] +subset: gosubset_prok +synonym: "cyanide anabolism" EXACT [] +synonym: "cyanide biosynthesis" EXACT [] +synonym: "cyanide formation" EXACT [] +synonym: "cyanide synthesis" EXACT [] +is_a: GO:0019499 ! cyanide metabolic process +is_a: GO:0019753 ! one-carbon compound biosynthetic process +is_a: GO:0044271 ! nitrogen compound biosynthetic process + +[Term] +id: GO:0046203 +name: spermidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +subset: gosubset_prok +synonym: "spermidine breakdown" EXACT [] +synonym: "spermidine catabolism" EXACT [] +synonym: "spermidine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0008216 ! spermidine metabolic process + +[Term] +id: GO:0046204 +name: nor-spermidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +subset: gosubset_prok +synonym: "nor-spermidine metabolism" EXACT [] +is_a: GO:0008216 ! spermidine metabolic process + +[Term] +id: GO:0046205 +name: nor-spermidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +subset: gosubset_prok +synonym: "nor-spermidine breakdown" EXACT [] +synonym: "nor-spermidine catabolism" EXACT [] +synonym: "nor-spermidine degradation" EXACT [] +is_a: GO:0046203 ! spermidine catabolic process +is_a: GO:0046204 ! nor-spermidine metabolic process + +[Term] +id: GO:0046206 +name: trypanothione metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] +subset: gosubset_prok +synonym: "trypanothione metabolism" EXACT [] +is_a: GO:0008216 ! spermidine metabolic process + +[Term] +id: GO:0046207 +name: trypanothione catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] +subset: gosubset_prok +synonym: "trypanothione breakdown" EXACT [] +synonym: "trypanothione catabolism" EXACT [] +synonym: "trypanothione degradation" EXACT [] +is_a: GO:0046203 ! spermidine catabolic process +is_a: GO:0046206 ! trypanothione metabolic process + +[Term] +id: GO:0046208 +name: spermine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "spermine breakdown" EXACT [] +synonym: "spermine catabolism" EXACT [] +synonym: "spermine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0008215 ! spermine metabolic process + +[Term] +id: GO:0046209 +name: nitric oxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] +subset: gosubset_prok +synonym: "nitric oxide metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0046210 +name: nitric oxide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] +subset: gosubset_prok +synonym: "nitric oxide breakdown" EXACT [] +synonym: "nitric oxide catabolism" EXACT [] +synonym: "nitric oxide degradation" EXACT [] +is_a: GO:0044270 ! nitrogen compound catabolic process +is_a: GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:0046211 +name: (+)-camphor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone." [GOC:ai] +subset: gosubset_prok +synonym: "(+)-camphor anabolism" EXACT [] +synonym: "(+)-camphor biosynthesis" EXACT [] +synonym: "(+)-camphor formation" EXACT [] +synonym: "(+)-camphor synthesis" EXACT [] +is_a: GO:0018882 ! (+)-camphor metabolic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043693 ! monoterpene biosynthetic process + +[Term] +id: GO:0046212 +name: methyl ethyl ketone biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai] +comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "methyl ethyl ketone anabolism" EXACT [] +synonym: "methyl ethyl ketone biosynthesis" EXACT [] +synonym: "methyl ethyl ketone formation" EXACT [] +synonym: "methyl ethyl ketone synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018928 + +[Term] +id: GO:0046213 +name: methyl ethyl ketone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai] +subset: gosubset_prok +synonym: "methyl ethyl ketone breakdown" EXACT [] +synonym: "methyl ethyl ketone catabolism" EXACT [] +synonym: "methyl ethyl ketone degradation" EXACT [] +is_a: GO:0018928 ! methyl ethyl ketone metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042182 ! ketone catabolic process + +[Term] +id: GO:0046214 +name: enterobactin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai] +subset: gosubset_prok +synonym: "enterobactin breakdown" EXACT [] +synonym: "enterobactin catabolism" EXACT [] +synonym: "enterobactin degradation" EXACT [] +is_a: GO:0009238 ! enterobactin metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046215 ! siderophore catabolic process + +[Term] +id: GO:0046215 +name: siderophore catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai] +subset: gosubset_prok +synonym: "siderochrome catabolism" NARROW [] +synonym: "siderophore breakdown" EXACT [] +synonym: "siderophore catabolism" EXACT [] +synonym: "siderophore degradation" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0051187 ! cofactor catabolic process + +[Term] +id: GO:0046216 +name: indole phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] +subset: gosubset_prok +synonym: "indole phytoalexin breakdown" EXACT [] +synonym: "indole phytoalexin catabolism" EXACT [] +synonym: "indole phytoalexin degradation" EXACT [] +is_a: GO:0042436 ! indole derivative catabolic process +is_a: GO:0046217 ! indole phytoalexin metabolic process +is_a: GO:0052316 ! phytoalexin catabolic process + +[Term] +id: GO:0046217 +name: indole phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] +subset: gosubset_prok +synonym: "indole phytoalexin metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042431 ! indole metabolic process +is_a: GO:0042434 ! indole derivative metabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0046218 +name: indolalkylamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "indolalkylamine breakdown" EXACT [] +synonym: "indolalkylamine catabolism" EXACT [] +synonym: "indolalkylamine degradation" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process +is_a: GO:0042436 ! indole derivative catabolic process + +[Term] +id: GO:0046219 +name: indolalkylamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "indolalkylamine anabolism" EXACT [] +synonym: "indolalkylamine biosynthesis" EXACT [] +synonym: "indolalkylamine formation" EXACT [] +synonym: "indolalkylamine synthesis" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process +is_a: GO:0042435 ! indole derivative biosynthetic process + +[Term] +id: GO:0046220 +name: pyridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai] +subset: gosubset_prok +synonym: "pyridine anabolism" EXACT [] +synonym: "pyridine biosynthesis" EXACT [] +synonym: "pyridine formation" EXACT [] +synonym: "pyridine synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019507 ! pyridine metabolic process + +[Term] +id: GO:0046221 +name: pyridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai] +subset: gosubset_prok +synonym: "pyridine breakdown" EXACT [] +synonym: "pyridine catabolism" EXACT [] +synonym: "pyridine degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019507 ! pyridine metabolic process + +[Term] +id: GO:0046222 +name: aflatoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] +subset: gosubset_prok +synonym: "aflatoxin metabolism" EXACT [] +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0043385 ! mycotoxin metabolic process + +[Term] +id: GO:0046223 +name: aflatoxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] +subset: gosubset_prok +synonym: "aflatoxin breakdown" EXACT [] +synonym: "aflatoxin catabolism" EXACT [] +synonym: "aflatoxin degradation" EXACT [] +is_a: GO:0043387 ! mycotoxin catabolic process +is_a: GO:0046222 ! aflatoxin metabolic process +is_a: GO:0046226 ! coumarin catabolic process + +[Term] +id: GO:0046224 +name: bacteriocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] +subset: gosubset_prok +synonym: "bacteriocin metabolism" EXACT [] +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0016999 ! antibiotic metabolic process + +[Term] +id: GO:0046225 +name: bacteriocin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] +subset: gosubset_prok +synonym: "bacteriocin breakdown" EXACT [] +synonym: "bacteriocin catabolism" EXACT [] +synonym: "bacteriocin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0046224 ! bacteriocin metabolic process + +[Term] +id: GO:0046226 +name: coumarin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai] +subset: gosubset_prok +synonym: "coumarin breakdown" EXACT [] +synonym: "coumarin catabolism" EXACT [] +synonym: "coumarin degradation" EXACT [] +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0046227 +name: 2,4,5-trichlorophenoxyacetic acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] +comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018980 + +[Term] +id: GO:0046228 +name: 2,4,5-trichlorophenoxyacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] +subset: gosubset_prok +synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT [] +is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0046229 +name: 2-aminobenzenesulfonate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] +comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2-aminobenzenesulfonate anabolism" EXACT [] +synonym: "2-aminobenzenesulfonate biosynthesis" EXACT [] +synonym: "2-aminobenzenesulfonate formation" EXACT [] +synonym: "2-aminobenzenesulfonate synthesis" EXACT [] +synonym: "2-aminobenzenesulphonate biosynthesis" EXACT [] +synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018868 + +[Term] +id: GO:0046230 +name: 2-aminobenzenesulfonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] +subset: gosubset_prok +synonym: "2-aminobenzenesulfonate breakdown" EXACT [] +synonym: "2-aminobenzenesulfonate catabolism" EXACT [] +synonym: "2-aminobenzenesulfonate degradation" EXACT [] +synonym: "2-aminobenzenesulphonate catabolic process" EXACT [] +synonym: "2-aminobenzenesulphonate catabolism" EXACT [] +is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0046231 +name: carbazole biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] +comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "carbazole anabolism" EXACT [] +synonym: "carbazole biosynthesis" EXACT [] +synonym: "carbazole formation" EXACT [] +synonym: "carbazole synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018884 + +[Term] +id: GO:0046232 +name: carbazole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] +subset: gosubset_prok +synonym: "carbazole breakdown" EXACT [] +synonym: "carbazole catabolism" EXACT [] +synonym: "carbazole degradation" EXACT [] +is_a: GO:0018884 ! carbazole metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046233 +name: 3-hydroxyphenylacetate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] +comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "3-hydroxyphenylacetate anabolism" EXACT [] +synonym: "3-hydroxyphenylacetate biosynthesis" EXACT [] +synonym: "3-hydroxyphenylacetate formation" EXACT [] +synonym: "3-hydroxyphenylacetate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0019609 + +[Term] +id: GO:0046234 +name: fluorene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai] +comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "fluorene anabolism" EXACT [] +synonym: "fluorene biosynthesis" EXACT [] +synonym: "fluorene formation" EXACT [] +synonym: "fluorene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018917 + +[Term] +id: GO:0046235 +name: gallate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai] +subset: gosubset_prok +synonym: "gallate anabolism" EXACT [] +synonym: "gallate biosynthesis" EXACT [] +synonym: "gallate formation" EXACT [] +synonym: "gallate synthesis" EXACT [] +synonym: "gallic acid biosynthesis" EXACT [] +synonym: "gallic acid biosynthetic process" EXACT [] +is_a: GO:0009713 ! catechol biosynthetic process +is_a: GO:0018918 ! gallate metabolic process + +[Term] +id: GO:0046236 +name: mandelate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai] +subset: gosubset_prok +synonym: "mandelate anabolism" EXACT [] +synonym: "mandelate biosynthesis" EXACT [] +synonym: "mandelate formation" EXACT [] +synonym: "mandelate synthesis" EXACT [] +is_a: GO:0018924 ! mandelate metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process + +[Term] +id: GO:0046237 +name: phenanthrene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "phenanthrene anabolism" EXACT [] +synonym: "phenanthrene biosynthesis" EXACT [] +synonym: "phenanthrene formation" EXACT [] +synonym: "phenanthrene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018955 + +[Term] +id: GO:0046238 +name: phthalate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai] +comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "phthalate anabolism" EXACT [] +synonym: "phthalate biosynthesis" EXACT [] +synonym: "phthalate formation" EXACT [] +synonym: "phthalate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018963 + +[Term] +id: GO:0046239 +name: phthalate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai] +subset: gosubset_prok +synonym: "phthalate breakdown" EXACT [] +synonym: "phthalate catabolism" EXACT [] +synonym: "phthalate degradation" EXACT [] +is_a: GO:0018963 ! phthalate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0046240 +name: xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai] +comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "xylene anabolism" EXACT [] +synonym: "xylene biosynthesis" EXACT [] +synonym: "xylene formation" EXACT [] +synonym: "xylene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018948 + +[Term] +id: GO:0046241 +name: m-xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "m-xylene anabolism" EXACT [] +synonym: "m-xylene biosynthesis" EXACT [] +synonym: "m-xylene formation" EXACT [] +synonym: "m-xylene synthesis" EXACT [] +synonym: "meta-xylene biosynthesis" EXACT [] +synonym: "meta-xylene biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018949 + +[Term] +id: GO:0046242 +name: o-xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "o-xylene anabolism" EXACT [] +synonym: "o-xylene biosynthesis" EXACT [] +synonym: "o-xylene formation" EXACT [] +synonym: "o-xylene synthesis" EXACT [] +synonym: "ortho-xylene biosynthesis" EXACT [] +synonym: "ortho-xylene biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018950 + +[Term] +id: GO:0046243 +name: p-xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "p-xylene anabolism" EXACT [] +synonym: "p-xylene biosynthesis" EXACT [] +synonym: "p-xylene formation" EXACT [] +synonym: "p-xylene synthesis" EXACT [] +synonym: "para-xylene biosynthesis" EXACT [] +synonym: "para-xylene biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018951 + +[Term] +id: GO:0046244 +name: salicylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "salicylic acid breakdown" EXACT [] +synonym: "salicylic acid catabolism" EXACT [] +synonym: "salicylic acid degradation" EXACT [] +is_a: GO:0009696 ! salicylic acid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0046245 +name: styrene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai] +comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "styrene anabolism" EXACT [] +synonym: "styrene biosynthesis" EXACT [] +synonym: "styrene formation" EXACT [] +synonym: "styrene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018966 + +[Term] +id: GO:0046246 +name: terpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] +subset: gosubset_prok +synonym: "terpene anabolism" EXACT [] +synonym: "terpene biosynthesis" EXACT [] +synonym: "terpene formation" EXACT [] +synonym: "terpene synthesis" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0046247 +name: terpene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] +subset: gosubset_prok +synonym: "terpene breakdown" EXACT [] +synonym: "terpene catabolism" EXACT [] +synonym: "terpene degradation" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0046248 +name: alpha-pinene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] +subset: gosubset_prok +synonym: "alpha-pinene anabolism" EXACT [] +synonym: "alpha-pinene biosynthesis" EXACT [] +synonym: "alpha-pinene formation" EXACT [] +synonym: "alpha-pinene synthesis" EXACT [] +is_a: GO:0018867 ! alpha-pinene metabolic process +is_a: GO:0043693 ! monoterpene biosynthetic process + +[Term] +id: GO:0046249 +name: alpha-pinene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] +subset: gosubset_prok +synonym: "alpha-pinene breakdown" EXACT [] +synonym: "alpha-pinene catabolism" EXACT [] +synonym: "alpha-pinene degradation" EXACT [] +is_a: GO:0018867 ! alpha-pinene metabolic process +is_a: GO:0043694 ! monoterpene catabolic process + +[Term] +id: GO:0046250 +name: limonene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] +subset: gosubset_prok +synonym: "limonene anabolism" EXACT [] +synonym: "limonene biosynthesis" EXACT [] +synonym: "limonene formation" EXACT [] +synonym: "limonene synthesis" EXACT [] +is_a: GO:0018923 ! limonene metabolic process +is_a: GO:0043693 ! monoterpene biosynthetic process + +[Term] +id: GO:0046251 +name: limonene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] +subset: gosubset_prok +synonym: "limonene breakdown" EXACT [] +synonym: "limonene catabolism" EXACT [] +synonym: "limonene degradation" EXACT [] +is_a: GO:0018923 ! limonene metabolic process +is_a: GO:0043694 ! monoterpene catabolic process + +[Term] +id: GO:0046252 +name: toluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai] +comment: This term was made obsolete because toluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "toluene anabolism" EXACT [] +synonym: "toluene biosynthesis" EXACT [] +synonym: "toluene formation" EXACT [] +synonym: "toluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018970 + +[Term] +id: GO:0046253 +name: anaerobic toluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai] +comment: This term was made obsolete because toluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "anaerobic toluene anabolism" EXACT [] +synonym: "anaerobic toluene biosynthesis" EXACT [] +synonym: "anaerobic toluene formation" EXACT [] +synonym: "anaerobic toluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018971 + +[Term] +id: GO:0046254 +name: anaerobic toluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic toluene breakdown" EXACT [] +synonym: "anaerobic toluene catabolism" EXACT [] +synonym: "anaerobic toluene degradation" EXACT [] +xref: MetaCyc:PWY-81 +is_a: GO:0018971 ! anaerobic toluene metabolic process +is_a: GO:0042203 ! toluene catabolic process + +[Term] +id: GO:0046255 +name: 2,4,6-trinitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] +comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2,4,6-trinitrotoluene anabolism" EXACT [] +synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT [] +synonym: "2,4,6-trinitrotoluene formation" EXACT [] +synonym: "2,4,6-trinitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018974 + +[Term] +id: GO:0046256 +name: 2,4,6-trinitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai] +subset: gosubset_prok +synonym: "2,4,6-trinitrotoluene breakdown" EXACT [] +synonym: "2,4,6-trinitrotoluene catabolism" EXACT [] +synonym: "2,4,6-trinitrotoluene degradation" EXACT [] +is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process +is_a: GO:0046260 ! trinitrotoluene catabolic process + +[Term] +id: GO:0046257 +name: anaerobic 2,4,6-trinitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] +comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018975 + +[Term] +id: GO:0046258 +name: anaerobic 2,4,6-trinitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] +subset: gosubset_prok +synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT [] +is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process +is_a: GO:0046254 ! anaerobic toluene catabolic process +is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process + +[Term] +id: GO:0046259 +name: trinitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai] +comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "trinitrotoluene anabolism" EXACT [] +synonym: "trinitrotoluene biosynthesis" EXACT [] +synonym: "trinitrotoluene formation" EXACT [] +synonym: "trinitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018973 + +[Term] +id: GO:0046260 +name: trinitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] +subset: gosubset_prok +synonym: "trinitrotoluene breakdown" EXACT [] +synonym: "trinitrotoluene catabolism" EXACT [] +synonym: "trinitrotoluene degradation" EXACT [] +is_a: GO:0018973 ! trinitrotoluene metabolic process +is_a: GO:0046263 ! nitrotoluene catabolic process + +[Term] +id: GO:0046261 +name: 4-nitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] +comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "4-nitrotoluene anabolism" EXACT [] +synonym: "4-nitrotoluene biosynthesis" EXACT [] +synonym: "4-nitrotoluene formation" EXACT [] +synonym: "4-nitrotoluene synthesis" EXACT [] +synonym: "4NT biosynthesis" EXACT [] +synonym: "4NT biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0019257 + +[Term] +id: GO:0046262 +name: nitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] +comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "nitrotoluene anabolism" EXACT [] +synonym: "nitrotoluene biosynthesis" EXACT [] +synonym: "nitrotoluene formation" EXACT [] +synonym: "nitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0019326 + +[Term] +id: GO:0046263 +name: nitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] +subset: gosubset_prok +synonym: "nitrotoluene breakdown" EXACT [] +synonym: "nitrotoluene catabolism" EXACT [] +synonym: "nitrotoluene degradation" EXACT [] +is_a: GO:0019326 ! nitrotoluene metabolic process +is_a: GO:0042203 ! toluene catabolic process + +[Term] +id: GO:0046264 +name: thiocyanate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai] +comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "thiocyanate anabolism" EXACT [] +synonym: "thiocyanate biosynthesis" EXACT [] +synonym: "thiocyanate formation" EXACT [] +synonym: "thiocyanate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018969 + +[Term] +id: GO:0046265 +name: thiocyanate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai] +subset: gosubset_prok +synonym: "thiocyanate breakdown" EXACT [] +synonym: "thiocyanate catabolism" EXACT [] +synonym: "thiocyanate degradation" EXACT [] +is_a: GO:0018969 ! thiocyanate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0046266 +name: triethanolamine biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] +comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "triethanolamine anabolism" EXACT [] +synonym: "triethanolamine biosynthesis" EXACT [] +synonym: "triethanolamine formation" EXACT [] +synonym: "triethanolamine synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018981 + +[Term] +id: GO:0046267 +name: triethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] +subset: gosubset_prok +synonym: "triethanolamine breakdown" EXACT [] +synonym: "triethanolamine catabolism" EXACT [] +synonym: "triethanolamine degradation" EXACT [] +is_a: GO:0018981 ! triethanolamine metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0046268 +name: toluene-4-sulfonate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] +comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "4-toluenesulfonate biosynthesis" EXACT [] +synonym: "4-toluenesulfonate biosynthetic process" EXACT [] +synonym: "toluene-4-sulfonate anabolism" EXACT [] +synonym: "toluene-4-sulfonate biosynthesis" EXACT [] +synonym: "toluene-4-sulfonate formation" EXACT [] +synonym: "toluene-4-sulfonate synthesis" EXACT [] +synonym: "toluene-4-sulphonate biosynthesis" EXACT [] +synonym: "toluene-4-sulphonate biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018972 + +[Term] +id: GO:0046269 +name: toluene-4-sulfonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] +subset: gosubset_prok +synonym: "4-toluenesulfonate catabolic process" EXACT [] +synonym: "4-toluenesulfonate catabolism" EXACT [] +synonym: "toluene-4-sulfonate breakdown" EXACT [] +synonym: "toluene-4-sulfonate catabolism" EXACT [] +synonym: "toluene-4-sulfonate degradation" EXACT [] +synonym: "toluene-4-sulphonate catabolic process" EXACT [] +synonym: "toluene-4-sulphonate catabolism" EXACT [] +is_a: GO:0018972 ! toluene-4-sulfonate metabolic process +is_a: GO:0042203 ! toluene catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0046270 +name: 4-toluenecarboxylate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] +comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "4-toluenecarboxylate anabolism" EXACT [] +synonym: "4-toluenecarboxylate biosynthesis" EXACT [] +synonym: "4-toluenecarboxylate formation" EXACT [] +synonym: "4-toluenecarboxylate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0019611 + +[Term] +id: GO:0046271 +name: phenylpropanoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai] +subset: gosubset_prok +synonym: "phenylpropanoid breakdown" EXACT [] +synonym: "phenylpropanoid catabolism" EXACT [] +synonym: "phenylpropanoid degradation" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0046272 +name: stilbene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai] +subset: gosubset_prok +synonym: "stilbene breakdown" EXACT [] +synonym: "stilbene catabolism" EXACT [] +synonym: "stilbene degradation" EXACT [] +is_a: GO:0009810 ! stilbene metabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0043451 ! alkene catabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046273 +name: lignan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] +subset: gosubset_prok +synonym: "lignan breakdown" EXACT [] +synonym: "lignan catabolism" EXACT [] +synonym: "lignan degradation" EXACT [] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046274 +name: lignin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai] +subset: gosubset_prok +synonym: "lignin breakdown" EXACT [] +synonym: "lignin catabolism" EXACT [] +synonym: "lignin degradation" EXACT [] +is_a: GO:0009808 ! lignin metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046275 +name: flavonoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai] +subset: gosubset_prok +synonym: "flavonoid breakdown" EXACT [] +synonym: "flavonoid catabolism" EXACT [] +synonym: "flavonoid degradation" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046276 +name: methylgallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] +subset: gosubset_prok +synonym: "methylgallate breakdown" EXACT [] +synonym: "methylgallate catabolism" EXACT [] +synonym: "methylgallate degradation" EXACT [] +xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY +is_a: GO:0019396 ! gallate catabolic process +is_a: GO:0019489 ! methylgallate metabolic process + +[Term] +id: GO:0046277 +name: methylgallate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] +subset: gosubset_prok +synonym: "methylgallate anabolism" EXACT [] +synonym: "methylgallate biosynthesis" EXACT [] +synonym: "methylgallate formation" EXACT [] +synonym: "methylgallate synthesis" EXACT [] +is_a: GO:0019489 ! methylgallate metabolic process +is_a: GO:0046235 ! gallate biosynthetic process + +[Term] +id: GO:0046278 +name: protocatechuate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "protocatechuate metabolism" EXACT [] +is_a: GO:0009712 ! catechol metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0046279 +name: protocatechuate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protocatechuate, the anion of 3,4-dihydroxybenzoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "protocatechuate anabolism" EXACT [] +synonym: "protocatechuate biosynthesis" EXACT [] +synonym: "protocatechuate formation" EXACT [] +synonym: "protocatechuate synthesis" EXACT [] +is_a: GO:0009713 ! catechol biosynthetic process +is_a: GO:0046278 ! protocatechuate metabolic process + +[Term] +id: GO:0046280 +name: chalcone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai] +subset: gosubset_prok +synonym: "chalcone breakdown" EXACT [] +synonym: "chalcone catabolism" EXACT [] +synonym: "chalcone degradation" EXACT [] +is_a: GO:0009714 ! chalcone metabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046281 +name: cinnamic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "cinnamic acid breakdown" EXACT [] +synonym: "cinnamic acid catabolism" EXACT [] +synonym: "cinnamic acid degradation" EXACT [] +synonym: "cinnamylic acid catabolic process" EXACT [] +synonym: "cinnamylic acid catabolism" EXACT [] +synonym: "phenylacrylic acid catabolic process" EXACT [] +synonym: "phenylacrylic acid catabolism" EXACT [] +is_a: GO:0009803 ! cinnamic acid metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046282 +name: cinnamic acid ester catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "cinnamic acid ester breakdown" EXACT [] +synonym: "cinnamic acid ester catabolism" EXACT [] +synonym: "cinnamic acid ester degradation" EXACT [] +is_a: GO:0009801 ! cinnamic acid ester metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046283 +name: anthocyanin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "anthocyanin metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0046284 +name: anthocyanin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] +subset: gosubset_prok +synonym: "anthocyanin breakdown" EXACT [] +synonym: "anthocyanin catabolism" EXACT [] +synonym: "anthocyanin degradation" EXACT [] +is_a: GO:0046149 ! pigment catabolic process +is_a: GO:0046275 ! flavonoid catabolic process +is_a: GO:0046283 ! anthocyanin metabolic process + +[Term] +id: GO:0046285 +name: flavonoid phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "flavonoid phytoalexin metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process + +[Term] +id: GO:0046286 +name: flavonoid phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +subset: gosubset_prok +synonym: "flavonoid phytoalexin breakdown" EXACT [] +synonym: "flavonoid phytoalexin catabolism" EXACT [] +synonym: "flavonoid phytoalexin degradation" EXACT [] +is_a: GO:0046275 ! flavonoid catabolic process +is_a: GO:0046285 ! flavonoid phytoalexin metabolic process + +[Term] +id: GO:0046287 +name: isoflavonoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring moiety." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "isoflavonoid metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process + +[Term] +id: GO:0046288 +name: isoflavonoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] +subset: gosubset_prok +synonym: "isoflavonoid breakdown" EXACT [] +synonym: "isoflavonoid catabolism" EXACT [] +synonym: "isoflavonoid degradation" EXACT [] +is_a: GO:0046275 ! flavonoid catabolic process +is_a: GO:0046287 ! isoflavonoid metabolic process + +[Term] +id: GO:0046289 +name: isoflavonoid phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +subset: gosubset_prok +synonym: "isoflavonoid phytoalexin metabolism" EXACT [] +is_a: GO:0046285 ! flavonoid phytoalexin metabolic process +is_a: GO:0046287 ! isoflavonoid metabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0046290 +name: isoflavonoid phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +subset: gosubset_prok +synonym: "isoflavonoid phytoalexin breakdown" EXACT [] +synonym: "isoflavonoid phytoalexin catabolism" EXACT [] +synonym: "isoflavonoid phytoalexin degradation" EXACT [] +is_a: GO:0046286 ! flavonoid phytoalexin catabolic process +is_a: GO:0046288 ! isoflavonoid catabolic process +is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process +is_a: GO:0052316 ! phytoalexin catabolic process + +[Term] +id: GO:0046291 +name: 6-hydroxycineole biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] +comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "6-endo-hydroxycineole biosynthesis" EXACT [] +synonym: "6-endo-hydroxycineole biosynthetic process" EXACT [] +synonym: "6-hydroxycineole anabolism" EXACT [] +synonym: "6-hydroxycineole biosynthesis" EXACT [] +synonym: "6-hydroxycineole formation" EXACT [] +synonym: "6-hydroxycineole synthesis" EXACT [] +synonym: "hydroxycineol biosynthesis" EXACT [] +synonym: "hydroxycineol biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0019638 + +[Term] +id: GO:0046292 +name: formaldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [GOC:ai, http://cancerweb.ncl.ac.uk/, http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "formaldehyde metabolism" EXACT [] +synonym: "methanal metabolic process" EXACT [] +synonym: "methanal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0006730 ! one-carbon compound metabolic process + +[Term] +id: GO:0046293 +name: formaldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] +subset: gosubset_prok +synonym: "formaldehyde anabolism" EXACT [] +synonym: "formaldehyde biosynthesis" EXACT [] +synonym: "formaldehyde formation" EXACT [] +synonym: "formaldehyde synthesis" EXACT [] +synonym: "methanal biosynthesis" EXACT [] +synonym: "methanal biosynthetic process" EXACT [] +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0046292 ! formaldehyde metabolic process + +[Term] +id: GO:0046294 +name: formaldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] +subset: gosubset_prok +synonym: "formaldehyde breakdown" EXACT [] +synonym: "formaldehyde catabolism" EXACT [] +synonym: "formaldehyde degradation" EXACT [] +synonym: "methanal catabolic process" EXACT [] +synonym: "methanal catabolism" EXACT [] +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046292 ! formaldehyde metabolic process + +[Term] +id: GO:0046295 +name: glycolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] +subset: gosubset_prok +synonym: "glycolate anabolism" EXACT [] +synonym: "glycolate biosynthesis" EXACT [] +synonym: "glycolate formation" EXACT [] +synonym: "glycolate synthesis" EXACT [] +is_a: GO:0009441 ! glycolate metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0046296 +name: glycolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] +subset: gosubset_prok +synonym: "glycolate breakdown" EXACT [] +synonym: "glycolate catabolism" EXACT [] +synonym: "glycolate degradation" EXACT [] +is_a: GO:0009441 ! glycolate metabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0046297 +name: 2,4-dichlorobenzoate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] +comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2,4-dichlorobenzoate anabolism" EXACT [] +synonym: "2,4-dichlorobenzoate biosynthesis" EXACT [] +synonym: "2,4-dichlorobenzoate formation" EXACT [] +synonym: "2,4-dichlorobenzoate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018898 + +[Term] +id: GO:0046298 +name: 2,4-dichlorobenzoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] +subset: gosubset_prok +synonym: "2,4-dichlorobenzoate breakdown" EXACT [] +synonym: "2,4-dichlorobenzoate catabolism" EXACT [] +synonym: "2,4-dichlorobenzoate degradation" EXACT [] +is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0046299 +name: 2,4-dichlorophenoxyacetic acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] +comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018901 + +[Term] +id: GO:0046300 +name: 2,4-dichlorophenoxyacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] +subset: gosubset_prok +synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT [] +is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0046301 +name: 2-chloro-N-isopropylacetanilide biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] +comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide formation" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018889 + +[Term] +id: GO:0046302 +name: 2-chloro-N-isopropylacetanilide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] +subset: gosubset_prok +synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT [] +is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0046303 +name: 2-nitropropane biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] +comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2-nitropropane anabolism" EXACT [] +synonym: "2-nitropropane biosynthesis" EXACT [] +synonym: "2-nitropropane formation" EXACT [] +synonym: "2-nitropropane synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018938 + +[Term] +id: GO:0046304 +name: 2-nitropropane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] +subset: gosubset_prok +synonym: "2-nitropropane breakdown" EXACT [] +synonym: "2-nitropropane catabolism" EXACT [] +synonym: "2-nitropropane degradation" EXACT [] +is_a: GO:0018938 ! 2-nitropropane metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043448 ! alkane catabolic process +is_a: GO:0044270 ! nitrogen compound catabolic process + +[Term] +id: GO:0046305 +name: alkanesulfonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:ai] +subset: gosubset_prok +synonym: "alkanesulfonate anabolism" EXACT [] +synonym: "alkanesulfonate biosynthesis" EXACT [] +synonym: "alkanesulfonate formation" EXACT [] +synonym: "alkanesulfonate synthesis" EXACT [] +synonym: "alkanesulphonate biosynthesis" EXACT [] +synonym: "alkanesulphonate biosynthetic process" EXACT [] +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0046306 +name: alkanesulfonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:ai] +subset: gosubset_prok +synonym: "alkanesulfonate breakdown" EXACT [] +synonym: "alkanesulfonate catabolism" EXACT [] +synonym: "alkanesulfonate degradation" EXACT [] +synonym: "alkanesulphonate catabolic process" EXACT [] +synonym: "alkanesulphonate catabolism" EXACT [] +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0046307 +name: Z-phenylacetaldoxime biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] +subset: gosubset_prok +synonym: "Z-phenylacetaldoxime anabolism" EXACT [] +synonym: "Z-phenylacetaldoxime biosynthesis" EXACT [] +synonym: "Z-phenylacetaldoxime formation" EXACT [] +synonym: "Z-phenylacetaldoxime synthesis" EXACT [] +is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0046308 +name: Z-phenylacetaldoxime catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] +subset: gosubset_prok +synonym: "Z-phenylacetaldoxime breakdown" EXACT [] +synonym: "Z-phenylacetaldoxime catabolism" EXACT [] +synonym: "Z-phenylacetaldoxime degradation" EXACT [] +is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0046309 +name: 1,3-dichloro-2-propanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] +subset: gosubset_prok +synonym: "1,3-dichloro-2-propanol anabolism" EXACT [] +synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT [] +synonym: "1,3-dichloro-2-propanol formation" EXACT [] +synonym: "1,3-dichloro-2-propanol synthesis" EXACT [] +is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0046310 +name: 1,3-dichloro-2-propanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] +subset: gosubset_prok +synonym: "1,3-dichloro-2-propanol breakdown" EXACT [] +synonym: "1,3-dichloro-2-propanol catabolism" EXACT [] +synonym: "1,3-dichloro-2-propanol degradation" EXACT [] +is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process +is_a: GO:0042219 ! amino acid derivative catabolic process + +[Term] +id: GO:0046311 +name: prenylcysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] +subset: gosubset_prok +synonym: "prenylcysteine anabolism" EXACT [] +synonym: "prenylcysteine biosynthesis" EXACT [] +synonym: "prenylcysteine formation" EXACT [] +synonym: "prenylcysteine synthesis" EXACT [] +is_a: GO:0030329 ! prenylcysteine metabolic process +is_a: GO:0042398 ! amino acid derivative biosynthetic process + +[Term] +id: GO:0046312 +name: phosphoarginine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] +subset: gosubset_prok +synonym: "phosphoarginine anabolism" EXACT [] +synonym: "phosphoarginine biosynthesis" EXACT [] +synonym: "phosphoarginine formation" EXACT [] +synonym: "phosphoarginine synthesis" EXACT [] +is_a: GO:0006604 ! phosphoarginine metabolic process +is_a: GO:0042396 ! phosphagen biosynthetic process + +[Term] +id: GO:0046313 +name: phosphoarginine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] +subset: gosubset_prok +synonym: "phosphoarginine breakdown" EXACT [] +synonym: "phosphoarginine catabolism" EXACT [] +synonym: "phosphoarginine degradation" EXACT [] +is_a: GO:0006604 ! phosphoarginine metabolic process +is_a: GO:0042397 ! phosphagen catabolic process + +[Term] +id: GO:0046314 +name: phosphocreatine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] +subset: gosubset_prok +synonym: "phosphocreatine anabolism" EXACT [] +synonym: "phosphocreatine biosynthesis" EXACT [] +synonym: "phosphocreatine formation" EXACT [] +synonym: "phosphocreatine synthesis" EXACT [] +is_a: GO:0006603 ! phosphocreatine metabolic process +is_a: GO:0042396 ! phosphagen biosynthetic process + +[Term] +id: GO:0046315 +name: phosphocreatine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] +subset: gosubset_prok +synonym: "phosphocreatine breakdown" EXACT [] +synonym: "phosphocreatine catabolism" EXACT [] +synonym: "phosphocreatine degradation" EXACT [] +is_a: GO:0006603 ! phosphocreatine metabolic process +is_a: GO:0042397 ! phosphagen catabolic process + +[Term] +id: GO:0046316 +name: gluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-gluconate = ADP + 6-phospho-D-gluconate." [EC:2.7.1.12] +subset: gosubset_prok +synonym: "ATP:D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.12] +synonym: "gluconate kinase activity" EXACT [EC:2.7.1.12] +synonym: "gluconokinase (phosphorylating)" EXACT [EC:2.7.1.12] +xref: EC:2.7.1.12 +xref: MetaCyc:GLUCONOKIN-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0046317 +name: regulation of glucosylceramide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of glucosylceramide anabolism" EXACT [] +synonym: "regulation of glucosylceramide biosynthesis" EXACT [] +synonym: "regulation of glucosylceramide formation" EXACT [] +synonym: "regulation of glucosylceramide synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process + +[Term] +id: GO:0046318 +name: negative regulation of glucosylceramide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "downregulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "inhibition of glucosylceramide biosynthetic process" NARROW [] +synonym: "negative regulation of glucosylceramide anabolism" EXACT [] +synonym: "negative regulation of glucosylceramide biosynthesis" EXACT [] +synonym: "negative regulation of glucosylceramide formation" EXACT [] +synonym: "negative regulation of glucosylceramide synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process + +[Term] +id: GO:0046319 +name: positive regulation of glucosylceramide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai] +subset: gosubset_prok +synonym: "activation of glucosylceramide biosynthetic process" NARROW [] +synonym: "positive regulation of glucosylceramide anabolism" EXACT [] +synonym: "positive regulation of glucosylceramide biosynthesis" EXACT [] +synonym: "positive regulation of glucosylceramide formation" EXACT [] +synonym: "positive regulation of glucosylceramide synthesis" EXACT [] +synonym: "stimulation of glucosylceramide biosynthetic process" NARROW [] +synonym: "up regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "upregulation of glucosylceramide biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process + +[Term] +id: GO:0046320 +name: regulation of fatty acid oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai] +subset: gosubset_prok +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0046321 +name: positive regulation of fatty acid oxidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai] +subset: gosubset_prok +synonym: "activation of fatty acid oxidation" NARROW [] +synonym: "stimulation of fatty acid oxidation" NARROW [] +synonym: "up regulation of fatty acid oxidation" EXACT [] +synonym: "up-regulation of fatty acid oxidation" EXACT [] +synonym: "upregulation of fatty acid oxidation" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0046320 ! regulation of fatty acid oxidation +relationship: positively_regulates GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0046322 +name: negative regulation of fatty acid oxidation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of fatty acid oxidation" EXACT [] +synonym: "down-regulation of fatty acid oxidation" EXACT [] +synonym: "downregulation of fatty acid oxidation" EXACT [] +synonym: "inhibition of fatty acid oxidation" NARROW [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0046320 ! regulation of fatty acid oxidation +relationship: negatively_regulates GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0046323 +name: glucose import +namespace: biological_process +def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb] +xref: Reactome:212003 +xref: Reactome:221767 +xref: Reactome:230346 +xref: Reactome:238384 +xref: Reactome:244939 +xref: Reactome:249820 +xref: Reactome:252558 +xref: Reactome:255736 +xref: Reactome:259130 +xref: Reactome:262487 +xref: Reactome:274166 +xref: Reactome:280639 +xref: Reactome:282863 +xref: Reactome:288340 +xref: Reactome:70153 +is_a: GO:0015758 ! glucose transport + +[Term] +id: GO:0046324 +name: regulation of glucose import +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0046323 ! glucose import + +[Term] +id: GO:0046325 +name: negative regulation of glucose import +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +synonym: "down regulation of glucose import" EXACT [] +synonym: "down-regulation of glucose import" EXACT [] +synonym: "downregulation of glucose import" EXACT [] +synonym: "inhibition of glucose import" NARROW [] +synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0046324 ! regulation of glucose import +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0046323 ! glucose import + +[Term] +id: GO:0046326 +name: positive regulation of glucose import +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "activation of glucose import" NARROW [] +synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of glucose import" NARROW [] +synonym: "up regulation of glucose import" EXACT [] +synonym: "up-regulation of glucose import" EXACT [] +synonym: "upregulation of glucose import" EXACT [] +xref: GOC:dph +xref: GOC:tb +is_a: GO:0046324 ! regulation of glucose import +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0046323 ! glucose import + +[Term] +id: GO:0046327 +name: glycerol biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai] +subset: gosubset_prok +synonym: "glycerol anabolism from pyruvate" EXACT [] +synonym: "glycerol formation from pyruvate" EXACT [] +synonym: "glycerol synthesis from pyruvate" EXACT [] +synonym: "glyceroneogenesis" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0006114 ! glycerol biosynthetic process +relationship: part_of GO:0019432 ! triacylglycerol biosynthetic process + +[Term] +id: GO:0046328 +name: regulation of JNK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] +synonym: "regulation of SAPK cascade" BROAD [] +is_a: GO:0043408 ! regulation of MAPKKK cascade +relationship: regulates GO:0007254 ! JNK cascade + +[Term] +id: GO:0046329 +name: negative regulation of JNK cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] +synonym: "down regulation of JNK cascade" EXACT [] +synonym: "down-regulation of JNK cascade" EXACT [] +synonym: "downregulation of JNK cascade" EXACT [] +synonym: "inhibition of JNK cascade" NARROW [] +is_a: GO:0043409 ! negative regulation of MAPKKK cascade +is_a: GO:0046328 ! regulation of JNK cascade +relationship: negatively_regulates GO:0007254 ! JNK cascade + +[Term] +id: GO:0046330 +name: positive regulation of JNK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] +synonym: "activation of JNK cascade" NARROW [] +synonym: "stimulation of JNK cascade" NARROW [] +synonym: "up regulation of JNK cascade" EXACT [] +synonym: "up-regulation of JNK cascade" EXACT [] +synonym: "upregulation of JNK cascade" EXACT [] +is_a: GO:0043410 ! positive regulation of MAPKKK cascade +is_a: GO:0046328 ! regulation of JNK cascade +relationship: positively_regulates GO:0007254 ! JNK cascade + +[Term] +id: GO:0046331 +name: lateral inhibition +namespace: biological_process +def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] +is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment + +[Term] +id: GO:0046332 +name: SMAD binding +namespace: molecular_function +def: "Interacting selectively with a SMAD signaling protein." [GOC:ai] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046333 +name: octopamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "octopamine metabolism" EXACT [] +is_a: GO:0006576 ! biogenic amine metabolic process +is_a: GO:0042133 ! neurotransmitter metabolic process + +[Term] +id: GO:0046334 +name: octopamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "octopamine breakdown" EXACT [] +synonym: "octopamine catabolism" EXACT [] +synonym: "octopamine degradation" EXACT [] +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:0042402 ! biogenic amine catabolic process +is_a: GO:0046333 ! octopamine metabolic process + +[Term] +id: GO:0046335 +name: ethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] +subset: gosubset_prok +synonym: "ethanolamine anabolism" EXACT [] +synonym: "ethanolamine biosynthesis" EXACT [] +synonym: "ethanolamine formation" EXACT [] +synonym: "ethanolamine synthesis" EXACT [] +is_a: GO:0006580 ! ethanolamine metabolic process +is_a: GO:0042401 ! biogenic amine biosynthetic process + +[Term] +id: GO:0046336 +name: ethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] +subset: gosubset_prok +synonym: "ethanolamine breakdown" EXACT [] +synonym: "ethanolamine catabolism" EXACT [] +synonym: "ethanolamine degradation" EXACT [] +is_a: GO:0006580 ! ethanolamine metabolic process +is_a: GO:0042402 ! biogenic amine catabolic process + +[Term] +id: GO:0046337 +name: phosphatidylethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylethanolamine metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0046338 +name: phosphatidylethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylethanolamine breakdown" EXACT [] +synonym: "phosphatidylethanolamine catabolism" EXACT [] +synonym: "phosphatidylethanolamine degradation" EXACT [] +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0046336 ! ethanolamine catabolic process +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0046339 +name: diacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "diacylglycerol metabolism" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0046340 +name: diacylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "diacylglycerol breakdown" EXACT [] +synonym: "diacylglycerol catabolism" EXACT [] +synonym: "diacylglycerol degradation" EXACT [] +is_a: GO:0046339 ! diacylglycerol metabolic process +is_a: GO:0046464 ! acylglycerol catabolic process + +[Term] +id: GO:0046341 +name: CDP-diacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "CDP-diacylglycerol metabolism" EXACT [] +is_a: GO:0046339 ! diacylglycerol metabolic process + +[Term] +id: GO:0046342 +name: CDP-diacylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "CDP-diacylglycerol breakdown" EXACT [] +synonym: "CDP-diacylglycerol catabolism" EXACT [] +synonym: "CDP-diacylglycerol degradation" EXACT [] +is_a: GO:0046340 ! diacylglycerol catabolic process +is_a: GO:0046341 ! CDP-diacylglycerol metabolic process + +[Term] +id: GO:0046343 +name: streptomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "streptomycin metabolism" EXACT [] +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:0046344 +name: ecdysteroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai] +synonym: "ecdysteroid breakdown" EXACT [] +synonym: "ecdysteroid catabolism" EXACT [] +synonym: "ecdysteroid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0046345 +name: abscisic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "abscisic acid breakdown" EXACT [] +synonym: "abscisic acid catabolism" EXACT [] +synonym: "abscisic acid degradation" EXACT [] +is_a: GO:0009687 ! abscisic acid metabolic process +is_a: GO:0043290 ! apocarotenoid catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0046346 +name: mannosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "mannosamine breakdown" EXACT [] +synonym: "mannosamine catabolism" EXACT [] +synonym: "mannosamine degradation" EXACT [] +is_a: GO:0006050 ! mannosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0046347 +name: mannosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "mannosamine anabolism" EXACT [] +synonym: "mannosamine biosynthesis" EXACT [] +synonym: "mannosamine formation" EXACT [] +synonym: "mannosamine synthesis" EXACT [] +is_a: GO:0006050 ! mannosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0046348 +name: amino sugar catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "amino sugar breakdown" EXACT [] +synonym: "amino sugar catabolism" EXACT [] +synonym: "amino sugar degradation" EXACT [] +synonym: "aminosaccharide catabolic process" EXACT [] +synonym: "aminosaccharide catabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0046349 +name: amino sugar biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "amino sugar anabolism" EXACT [] +synonym: "amino sugar biosynthesis" EXACT [] +synonym: "amino sugar formation" EXACT [] +synonym: "amino sugar synthesis" EXACT [] +synonym: "aminosaccharide biosynthesis" EXACT [] +synonym: "aminosaccharide biosynthetic process" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0046350 +name: galactosaminoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] +subset: gosubset_prok +synonym: "galactosaminoglycan metabolism" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process + +[Term] +id: GO:0046351 +name: disaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] +subset: gosubset_prok +synonym: "disaccharide anabolism" EXACT [] +synonym: "disaccharide biosynthesis" EXACT [] +synonym: "disaccharide formation" EXACT [] +synonym: "disaccharide synthesis" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0046352 +name: disaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] +subset: gosubset_prok +synonym: "disaccharide breakdown" EXACT [] +synonym: "disaccharide catabolism" EXACT [] +synonym: "disaccharide degradation" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0046353 +name: aminoglycoside 3-N-acetyltransferase activity +namespace: molecular_function +alt_id: GO:0016991 +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb] +subset: gosubset_prok +synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81] +synonym: "3-N-aminoglycoside acetyltransferase activity" EXACT [EC:2.3.1.81] +synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" EXACT [EC:2.3.1.81] +synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60] +synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60] +synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60] +synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW [] +synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60] +synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81] +synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT [] +synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60] +xref: EC:2.3.1.60 +xref: EC:2.3.1.81 +xref: MetaCyc:AMINOGLYCOSIDE-N3'-ACETYLTRANSFERASE-RXN +xref: MetaCyc:GENTAMICIN-3'-N-ACETYLTRANSFERASE-RXN +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0046354 +name: mannan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannan anabolism" EXACT [] +synonym: "mannan biosynthesis" EXACT [] +synonym: "mannan formation" EXACT [] +synonym: "mannan synthesis" EXACT [] +is_a: GO:0010412 ! mannan metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0046355 +name: mannan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "mannan breakdown" EXACT [] +synonym: "mannan catabolism" EXACT [] +synonym: "mannan degradation" EXACT [] +is_a: GO:0010412 ! mannan metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0046356 +name: acetyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai] +subset: gosubset_prok +synonym: "acetyl-CoA breakdown" EXACT [] +synonym: "acetyl-CoA catabolism" EXACT [] +synonym: "acetyl-CoA degradation" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0009109 ! coenzyme catabolic process + +[Term] +id: GO:0046357 +name: galactarate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactarate anabolism" EXACT [] +synonym: "galactarate biosynthesis" EXACT [] +synonym: "galactarate formation" EXACT [] +synonym: "galactarate synthesis" EXACT [] +is_a: GO:0019578 ! aldaric acid biosynthetic process +is_a: GO:0019580 ! galactarate metabolic process + +[Term] +id: GO:0046358 +name: butyrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "butyrate anabolism" EXACT [] +synonym: "butyrate biosynthesis" EXACT [] +synonym: "butyrate formation" EXACT [] +synonym: "butyrate synthesis" EXACT [] +is_a: GO:0019605 ! butyrate metabolic process +is_a: GO:0051790 ! short-chain fatty acid biosynthetic process + +[Term] +id: GO:0046359 +name: butyrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "butyrate breakdown" EXACT [] +synonym: "butyrate catabolism" EXACT [] +synonym: "butyrate degradation" EXACT [] +is_a: GO:0019605 ! butyrate metabolic process +is_a: GO:0019626 ! short-chain fatty acid catabolic process + +[Term] +id: GO:0046360 +name: 2-oxobutyrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "2-oxobutyrate anabolism" EXACT [] +synonym: "2-oxobutyrate biosynthesis" EXACT [] +synonym: "2-oxobutyrate formation" EXACT [] +synonym: "2-oxobutyrate synthesis" EXACT [] +synonym: "alpha-ketobutyrate biosynthesis" EXACT [] +synonym: "alpha-ketobutyrate biosynthetic process" EXACT [] +is_a: GO:0046358 ! butyrate biosynthetic process +is_a: GO:0046361 ! 2-oxobutyrate metabolic process + +[Term] +id: GO:0046361 +name: 2-oxobutyrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [http://chemfinder.cambridgesoft.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "2-oxobutyrate metabolism" EXACT [] +synonym: "alpha-ketobutyrate metabolic process" EXACT [] +synonym: "alpha-ketobutyrate metabolism" EXACT [] +is_a: GO:0019605 ! butyrate metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0046362 +name: ribitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribitol anabolism" EXACT [] +synonym: "ribitol biosynthesis" EXACT [] +synonym: "ribitol formation" EXACT [] +synonym: "ribitol synthesis" EXACT [] +is_a: GO:0019322 ! pentose biosynthetic process +is_a: GO:0019349 ! ribitol metabolic process +is_a: GO:0019526 ! pentitol biosynthetic process + +[Term] +id: GO:0046363 +name: ribitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ribitol breakdown" EXACT [] +synonym: "ribitol catabolism" EXACT [] +synonym: "ribitol degradation" EXACT [] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:0019349 ! ribitol metabolic process +is_a: GO:0019527 ! pentitol catabolic process + +[Term] +id: GO:0046364 +name: monosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "monosaccharide anabolism" EXACT [] +synonym: "monosaccharide biosynthesis" EXACT [] +synonym: "monosaccharide formation" EXACT [] +synonym: "monosaccharide synthesis" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0046365 +name: monosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "monosaccharide breakdown" EXACT [] +synonym: "monosaccharide catabolism" EXACT [] +synonym: "monosaccharide degradation" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0046366 +name: allose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "allose anabolism" EXACT [] +synonym: "allose biosynthesis" EXACT [] +synonym: "allose formation" EXACT [] +synonym: "allose synthesis" EXACT [] +is_a: GO:0019313 ! allose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0046367 +name: allose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "allose breakdown" EXACT [] +synonym: "allose catabolism" EXACT [] +synonym: "allose degradation" EXACT [] +is_a: GO:0019313 ! allose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0046368 +name: GDP-L-fucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP-L-fucose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0042354 ! L-fucose metabolic process + +[Term] +id: GO:0046369 +name: galactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "galactose anabolism" EXACT [] +synonym: "galactose biosynthesis" EXACT [] +synonym: "galactose formation" EXACT [] +synonym: "galactose synthesis" EXACT [] +is_a: GO:0006012 ! galactose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0046370 +name: fructose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] +subset: gosubset_prok +synonym: "fructose anabolism" EXACT [] +synonym: "fructose biosynthesis" EXACT [] +synonym: "fructose formation" EXACT [] +synonym: "fructose synthesis" EXACT [] +is_a: GO:0006000 ! fructose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0046371 +name: dTDP-mannose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "dTDP-mannose metabolism" EXACT [] +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046372 +name: D-arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-arabinose, the dextrorotatory isomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-arabinose metabolism" EXACT [] +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0046373 +name: L-arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-arabinose, the levorotatory isomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-arabinose metabolism" EXACT [] +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0046374 +name: teichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "teichoic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046375 +name: K antigen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "K antigen metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046376 +name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT [] +is_a: GO:0019348 ! dolichol metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046377 +name: colanic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html] +subset: gosubset_prok +synonym: "colanic acid metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046378 +name: enterobacterial common antigen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] +subset: gosubset_prok +synonym: "enterobacterial common antigen metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046379 +name: extracellular polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai] +subset: gosubset_prok +synonym: "extracellular polysaccharide metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046380 +name: N-acetylneuraminate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "N-acetylneuraminate anabolism" EXACT [] +synonym: "N-acetylneuraminate biosynthesis" EXACT [] +synonym: "N-acetylneuraminate formation" EXACT [] +synonym: "N-acetylneuraminate synthesis" EXACT [] +is_a: GO:0006054 ! N-acetylneuraminate metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0046381 +name: CMP-N-acetylneuraminate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] +subset: gosubset_prok +synonym: "CMP-N-acetylneuraminate metabolism" EXACT [] +is_a: GO:0006054 ! N-acetylneuraminate metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046382 +name: GDP-D-rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP-D-rhamnose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0019299 ! rhamnose metabolic process + +[Term] +id: GO:0046383 +name: dTDP-rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "dTDP-rhamnose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0019299 ! rhamnose metabolic process + +[Term] +id: GO:0046384 +name: 2-deoxyribose 1-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "2-deoxyribose 1-phosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046385 +name: deoxyribose phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribose phosphate anabolism" EXACT [] +synonym: "deoxyribose phosphate biosynthesis" EXACT [] +synonym: "deoxyribose phosphate formation" EXACT [] +synonym: "deoxyribose phosphate synthesis" EXACT [] +is_a: GO:0019302 ! D-ribose biosynthetic process +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046386 +name: deoxyribose phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "deoxyribose phosphate breakdown" EXACT [] +synonym: "deoxyribose phosphate catabolism" EXACT [] +synonym: "deoxyribose phosphate degradation" EXACT [] +is_a: GO:0019303 ! D-ribose catabolic process +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046387 +name: deoxyribose 1,5-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046388 +name: deoxyribose 1-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribose 1-phosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046389 +name: deoxyribose 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai] +subset: gosubset_prok +synonym: "deoxyribose 5-phosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046390 +name: ribose phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] +subset: gosubset_prok +synonym: "ribose phosphate anabolism" EXACT [] +synonym: "ribose phosphate biosynthesis" EXACT [] +synonym: "ribose phosphate formation" EXACT [] +synonym: "ribose phosphate synthesis" EXACT [] +is_a: GO:0019302 ! D-ribose biosynthetic process +is_a: GO:0019693 ! ribose phosphate metabolic process + +[Term] +id: GO:0046391 +name: 5-phosphoribose 1-diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] +subset: gosubset_prok +synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT [] +synonym: "PRPP metabolic process" EXACT [] +xref: MetaCyc:PRPP-PWY +is_a: GO:0019693 ! ribose phosphate metabolic process + +[Term] +id: GO:0046392 +name: galactarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai] +subset: gosubset_prok +synonym: "galactarate breakdown" EXACT [] +synonym: "galactarate catabolism" EXACT [] +synonym: "galactarate degradation" EXACT [] +is_a: GO:0019579 ! aldaric acid catabolic process +is_a: GO:0019580 ! galactarate metabolic process + +[Term] +id: GO:0046393 +name: D-galactarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-galactarate, the dextrorotatory isomer of galactarate, the anion of galactaric acid." [GOC:ai] +subset: gosubset_prok +synonym: "D-galactarate metabolism" EXACT [] +is_a: GO:0019580 ! galactarate metabolic process + +[Term] +id: GO:0046394 +name: carboxylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carboxylic acid anabolism" EXACT [] +synonym: "carboxylic acid biosynthesis" EXACT [] +synonym: "carboxylic acid formation" EXACT [] +synonym: "carboxylic acid synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046395 +name: carboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "carboxylic acid breakdown" EXACT [] +synonym: "carboxylic acid catabolism" EXACT [] +synonym: "carboxylic acid degradation" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046396 +name: D-galacturonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-galacturonate, the dextrorotatory isomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-galacturonate metabolism" EXACT [] +is_a: GO:0019586 ! galacturonate metabolic process + +[Term] +id: GO:0046397 +name: galacturonate catabolic process +namespace: biological_process +alt_id: GO:0019587 +def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai] +subset: gosubset_prok +synonym: "galacturonate breakdown" EXACT [] +synonym: "galacturonate catabolism" EXACT [] +synonym: "galacturonate degradation" EXACT [] +is_a: GO:0019586 ! galacturonate metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0046398 +name: UDP-glucuronate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "UDP-glucuronate metabolism" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process + +[Term] +id: GO:0046399 +name: glucuronate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai] +subset: gosubset_prok +synonym: "glucuronate anabolism" EXACT [] +synonym: "glucuronate biosynthesis" EXACT [] +synonym: "glucuronate formation" EXACT [] +synonym: "glucuronate synthesis" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0046400 +name: ketodeoxyoctanoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ketodeoxyoctanoate, 2-keto-3-deoxy-D-octaonate, an acid present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3-deoxy-D-manno-octulosonic acid metabolic process" EXACT [] +synonym: "ketodeoxyoctanoate metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046401 +name: lipopolysaccharide core region metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipopolysaccharide core region metabolism" EXACT [] +synonym: "LPS core region metabolic process" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process + +[Term] +id: GO:0046402 +name: O antigen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "O antigen metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046403 +name: polynucleotide 3'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32] +comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'. +synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32] +synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32] +synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32] +synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32] +synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32] +xref: EC:3.1.3.32 +xref: MetaCyc:POLYNUCLEOTIDE-3'-PHOSPHATASE-RXN +is_a: GO:0019204 ! nucleotide phosphatase activity + +[Term] +id: GO:0046404 +name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [EC:2.7.1.78] +synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "ATP-dependent DNA kinase activity" EXACT [] +synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] +xref: EC:2.7.1.78 +xref: MetaCyc:POLYNUCLEOTIDE-5'-HYDROXYL-KINASE-RXN +is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity +is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity + +[Term] +id: GO:0046405 +name: glycerol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30] +subset: gosubset_prok +synonym: "glycerol dehydrase activity" EXACT [EC:4.2.1.30] +synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" EXACT [EC:4.2.1.30] +synonym: "glycerol hydro-lyase activity" EXACT [EC:4.2.1.30] +xref: EC:4.2.1.30 +xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0046406 +name: magnesium protoporphyrin IX methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + magnesium protoporphyrin = S-adenosyl-L-homocysteine + magnesium protoporphyrin monomethyl ester." [EC:2.1.1.11] +subset: gosubset_prok +synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] +synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT [] +synonym: "Mg-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11] +synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" EXACT [EC:2.1.1.11] +synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" EXACT [EC:2.1.1.11] +synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] +synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] +synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11] +xref: EC:2.1.1.11 +xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046408 +name: chlorophyll synthetase activity +namespace: molecular_function +def: "Catalysis of the esterification reaction: chlorophyllide a + phytyl pyrophosphate = chlorophyll a + pyrophosphate." [ISBN:0471331309 "Biochemical Pathways", PMID:8552034] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0046409 +name: p-coumarate 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the 3-hydroxylation reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H20 + NADP+." [PMID:11429408, PMID:11891223] +synonym: "cytochrome P450 CYP98A3" NARROW [] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0046410 +name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959] +subset: gosubset_prok +synonym: "2-oxoglutarate decarboxylase/SHCHC synthase activity" EXACT [EC:2.5.1.64] +synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase--alpha-ketoglutarate decarboxylase activity" EXACT [EC:2.5.1.64] +synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" EXACT [EC:2.5.1.64] +synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" EXACT [EC:2.5.1.64] +synonym: "isochorismate:2-oxoglutarate:cyclodienyltransferase (decarboxylating, pyruvate-forming)" EXACT [EC:2.5.1.64] +synonym: "SHCHC synthase activity" EXACT [EC:2.5.1.64] +xref: EC:2.5.1.64 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0046411 +name: 2-keto-3-deoxygluconate transport +namespace: biological_process +def: "The directed movement of 2-keto-3-deoxygluconate into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0046412 +name: phenylmercury acetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] +subset: gosubset_prok +synonym: "phenylmercury acetate metabolism" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process +is_a: GO:0042537 ! benzene and derivative metabolic process + +[Term] +id: GO:0046413 +name: organomercury catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] +subset: gosubset_prok +synonym: "organomercury breakdown" EXACT [] +synonym: "organomercury catabolism" EXACT [] +synonym: "organomercury degradation" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0046414 +name: organomercury biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] +subset: gosubset_prok +synonym: "organomercury anabolism" EXACT [] +synonym: "organomercury biosynthesis" EXACT [] +synonym: "organomercury formation" EXACT [] +synonym: "organomercury synthesis" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046415 +name: urate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "urate metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046416 +name: D-amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-amino acids, the dextrorotatory isomers of amino acids." [GOC:ai] +subset: gosubset_prok +synonym: "D-amino acid metabolism" EXACT [] +is_a: GO:0006520 ! amino acid metabolic process + +[Term] +id: GO:0046417 +name: chorismate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "chorismate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046418 +name: nopaline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai] +subset: gosubset_prok +synonym: "nopaline metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0046419 +name: octopine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai] +subset: gosubset_prok +synonym: "octopine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0046421 +name: methylisocitrate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30] +subset: gosubset_prok +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" EXACT [EC:4.1.3.30] +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" EXACT [EC:4.1.3.30] +synonym: "2-methylisocitrate lyase activity" EXACT [] +synonym: "MICL" RELATED [EC:4.1.3.30] +xref: EC:4.1.3.30 +xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0046422 +name: violaxanthin de-epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; also antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.10.99.3, GOC:ai, ISBN:0471331309 "Biochemical Pathways"] +synonym: "VDE" RELATED [EC:1.10.99.3] +synonym: "violaxanthin:ascorbate oxidoreductase activity" EXACT [EC:1.10.99.3] +xref: EC:1.10.99.3 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0046423 +name: allene-oxide cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6] +synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" EXACT [EC:5.3.99.6] +xref: EC:5.3.99.6 +xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0046424 +name: ferulate 5-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0046425 +name: regulation of JAK-STAT cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf] +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: regulates GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0046426 +name: negative regulation of JAK-STAT cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] +synonym: "down regulation of JAK-STAT cascade" EXACT [] +synonym: "down-regulation of JAK-STAT cascade" EXACT [] +synonym: "downregulation of JAK-STAT cascade" EXACT [] +synonym: "inhibition of JAK-STAT cascade" NARROW [] +is_a: GO:0010741 ! negative regulation of protein kinase cascade +is_a: GO:0046425 ! regulation of JAK-STAT cascade +relationship: negatively_regulates GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0046427 +name: positive regulation of JAK-STAT cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] +synonym: "activation of JAK-STAT cascade" NARROW [] +synonym: "stimulation of JAK-STAT cascade" NARROW [] +synonym: "up regulation of JAK-STAT cascade" EXACT [] +synonym: "up-regulation of JAK-STAT cascade" EXACT [] +synonym: "upregulation of JAK-STAT cascade" EXACT [] +is_a: GO:0010740 ! positive regulation of protein kinase cascade +is_a: GO:0046425 ! regulation of JAK-STAT cascade +relationship: positively_regulates GO:0007259 ! JAK-STAT cascade + +[Term] +id: GO:0046428 +name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + pyrophosphate + CO2." [MetaCyc:DMK-RXN] +synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT [] +xref: EC:2.5.1.- +xref: MetaCyc:DMK-RXN +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0046429 +name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.4.3, PMID:11752431] +subset: gosubset_prok +synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating)" EXACT [EC:1.17.4.3] +synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT [] +synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [EC:1.17.4.3] +xref: EC:1.17.4.3 +is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor + +[Term] +id: GO:0046430 +name: non-phosphorylated glucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai] +subset: gosubset_prok +synonym: "non-phosphorylated glucose metabolism" EXACT [] +is_a: GO:0006006 ! glucose metabolic process + +[Term] +id: GO:0046431 +name: (R)-4-hydroxymandelate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "(R)-4-hydroxymandelate metabolism" EXACT [] +is_a: GO:0018924 ! mandelate metabolic process +is_a: GO:0018958 ! phenol metabolic process + +[Term] +id: GO:0046432 +name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] +subset: gosubset_prok +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0046433 +name: 2-aminoethylphosphonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130] +subset: gosubset_prok +synonym: "2-aminoethylphosphonate metabolism" EXACT [] +synonym: "2-phosphonoethylamine metabolic process" EXACT [] +synonym: "2-phosphonoethylamine metabolism" EXACT [] +synonym: "ciliatine metabolic process" EXACT [] +synonym: "ciliatine metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0019634 ! phosphonate metabolic process + +[Term] +id: GO:0046434 +name: organophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] +subset: gosubset_prok +synonym: "organophosphate breakdown" EXACT [] +synonym: "organophosphate catabolism" EXACT [] +synonym: "organophosphate degradation" EXACT [] +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046435 +name: 3-(3-hydroxy)phenylpropionate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] +subset: gosubset_prok +synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT [] +is_a: GO:0018962 ! 3-phenylpropionate metabolic process + +[Term] +id: GO:0046436 +name: D-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-alanine, the dextrorotatory isomer of the amino acid alanine." [GOC:ai] +subset: gosubset_prok +synonym: "D-alanine metabolism" EXACT [] +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0046437 +name: D-amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the dextrorotatory isomer of amino acids." [GOC:ai] +subset: gosubset_prok +synonym: "D-amino acid anabolism" EXACT [] +synonym: "D-amino acid biosynthesis" EXACT [] +synonym: "D-amino acid formation" EXACT [] +synonym: "D-amino acid synthesis" EXACT [] +is_a: GO:0008652 ! amino acid biosynthetic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0046438 +name: D-cysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai] +subset: gosubset_prok +synonym: "D-cysteine metabolism" EXACT [] +is_a: GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:0046439 +name: L-cysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-cysteine, the levorotatory isomer of 2-amino-3-mercaptopropanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "L-cysteine metabolism" EXACT [] +is_a: GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:0046440 +name: L-lysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-lysine, the levorotatory isomer of (S)-2,6-diaminohexanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "L-lysine metabolism" EXACT [] +is_a: GO:0006553 ! lysine metabolic process + +[Term] +id: GO:0046441 +name: D-lysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-lysine, the dextrorotatory isomer of (S)-2,6-diaminohexanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "D-lysine metabolism" EXACT [] +is_a: GO:0006553 ! lysine metabolic process + +[Term] +id: GO:0046442 +name: aerobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] +subset: gosubset_prok +synonym: "aerobactin metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0046443 +name: FAD metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "FAD metabolism" EXACT [] +synonym: "flavin adenine dinucleotide metabolic process" EXACT [] +synonym: "flavin adenine dinucleotide metabolism" EXACT [] +synonym: "flavin-adenine dinucleotide metabolic process" EXACT [] +synonym: "flavin-adenine dinucleotide metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0042726 ! riboflavin and derivative metabolic process + +[Term] +id: GO:0046444 +name: FMN metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "FMN metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process +is_a: GO:0042726 ! riboflavin and derivative metabolic process + +[Term] +id: GO:0046445 +name: benzyl isoquinoline alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "benzyl isoquinoline alkaloid metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0046446 +name: purine alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] +subset: gosubset_prok +synonym: "purine alkaloid metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0046447 +name: terpenoid indole alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] +subset: gosubset_prok +synonym: "terpenoid indole alkaloid metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0046448 +name: tropane alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tropane alkaloid metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0046449 +name: creatinine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "creatinine metabolism" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046450 +name: dethiobiotin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "desthiobiotin metabolic process" EXACT [] +synonym: "desthiobiotin metabolism" EXACT [] +synonym: "dethiobiotin metabolism" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046451 +name: diaminopimelate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "diaminopimelate metabolism" EXACT [] +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046452 +name: dihydrofolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dihydrofolate metabolism" EXACT [] +synonym: "dihydrofolate reduction" NARROW [] +is_a: GO:0006760 ! folic acid and derivative metabolic process + +[Term] +id: GO:0046453 +name: dipyrrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] +subset: gosubset_prok +synonym: "dipyrrin metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0046454 +name: dimethylsilanediol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai] +subset: gosubset_prok +synonym: "dimethylsilanediol metabolism" EXACT [] +is_a: GO:0018945 ! organosilicon metabolic process +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:0046455 +name: organosilicon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai] +subset: gosubset_prok +synonym: "organosilicon breakdown" EXACT [] +synonym: "organosilicon catabolism" EXACT [] +synonym: "organosilicon degradation" EXACT [] +synonym: "organosilicone catabolic process" EXACT [] +synonym: "organosilicone catabolism" EXACT [] +is_a: GO:0018945 ! organosilicon metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046456 +name: icosanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "eicosanoid biosynthesis" EXACT [] +synonym: "eicosanoid biosynthetic process" EXACT [] +synonym: "icosanoid anabolism" EXACT [] +synonym: "icosanoid biosynthesis" EXACT [] +synonym: "icosanoid formation" EXACT [] +synonym: "icosanoid synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0006690 ! icosanoid metabolic process + +[Term] +id: GO:0046457 +name: prostanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai] +subset: gosubset_prok +synonym: "prostanoid anabolism" EXACT [] +synonym: "prostanoid biosynthesis" EXACT [] +synonym: "prostanoid formation" EXACT [] +synonym: "prostanoid synthesis" EXACT [] +is_a: GO:0006692 ! prostanoid metabolic process +is_a: GO:0046456 ! icosanoid biosynthetic process + +[Term] +id: GO:0046458 +name: hexadecanal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "hexadecanal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:0046459 +name: short-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "short-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0046460 +name: neutral lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] +subset: gosubset_prok +synonym: "neutral lipid anabolism" EXACT [] +synonym: "neutral lipid biosynthesis" EXACT [] +synonym: "neutral lipid formation" EXACT [] +synonym: "neutral lipid synthesis" EXACT [] +is_a: GO:0006638 ! neutral lipid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0046461 +name: neutral lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] +subset: gosubset_prok +synonym: "neutral lipid breakdown" EXACT [] +synonym: "neutral lipid catabolism" EXACT [] +synonym: "neutral lipid degradation" EXACT [] +is_a: GO:0006638 ! neutral lipid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0046462 +name: monoacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "monoacylglycerol metabolism" EXACT [] +synonym: "monoglyceride metabolic process" EXACT [] +synonym: "monoglyceride metabolism" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0046463 +name: acylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] +subset: gosubset_prok +synonym: "acylglycerol anabolism" EXACT [] +synonym: "acylglycerol biosynthesis" EXACT [] +synonym: "acylglycerol formation" EXACT [] +synonym: "acylglycerol synthesis" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process +is_a: GO:0045017 ! glycerolipid biosynthetic process +is_a: GO:0046460 ! neutral lipid biosynthetic process +is_a: GO:0046504 ! glycerol ether biosynthetic process + +[Term] +id: GO:0046464 +name: acylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] +subset: gosubset_prok +synonym: "acylglycerol breakdown" EXACT [] +synonym: "acylglycerol catabolism" EXACT [] +synonym: "acylglycerol degradation" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process +is_a: GO:0044269 ! glycerol ether catabolic process +is_a: GO:0046461 ! neutral lipid catabolic process +is_a: GO:0046503 ! glycerolipid catabolic process + +[Term] +id: GO:0046465 +name: dolichyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "dolichyl diphosphate metabolism" EXACT [] +is_a: GO:0019348 ! dolichol metabolic process + +[Term] +id: GO:0046466 +name: membrane lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] +subset: gosubset_prok +synonym: "membrane lipid breakdown" EXACT [] +synonym: "membrane lipid catabolism" EXACT [] +synonym: "membrane lipid degradation" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0046467 +name: membrane lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] +subset: gosubset_prok +synonym: "membrane lipid anabolism" EXACT [] +synonym: "membrane lipid biosynthesis" EXACT [] +synonym: "membrane lipid formation" EXACT [] +synonym: "membrane lipid synthesis" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046468 +name: phosphatidyl-N-monomethylethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [http://www.lipid.co.uk] +subset: gosubset_prok +synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT [] +synonym: "PMME metabolic process" EXACT [] +synonym: "PMME metabolism" EXACT [] +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0046469 +name: platelet activating factor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] +synonym: "PAF metabolic process" EXACT [] +synonym: "PAF metabolism" EXACT [] +synonym: "platelet activating factor metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:0046470 +name: phosphatidylcholine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylcholine metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046471 +name: phosphatidylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylglycerol metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046473 +name: phosphatidic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidic acid metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046474 +name: glycerophospholipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerophospholipid anabolism" EXACT [] +synonym: "glycerophospholipid biosynthesis" EXACT [] +synonym: "glycerophospholipid formation" EXACT [] +synonym: "glycerophospholipid synthesis" EXACT [] +synonym: "phosphoglyceride biosynthesis" EXACT [] +synonym: "phosphoglyceride biosynthetic process" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0008654 ! phospholipid biosynthetic process + +[Term] +id: GO:0046475 +name: glycerophospholipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycerophospholipid breakdown" EXACT [] +synonym: "glycerophospholipid catabolism" EXACT [] +synonym: "glycerophospholipid degradation" EXACT [] +synonym: "phosphoglyceride catabolic process" EXACT [] +synonym: "phosphoglyceride catabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0009395 ! phospholipid catabolic process + +[Term] +id: GO:0046476 +name: glycosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "glycosylceramide anabolism" EXACT [] +synonym: "glycosylceramide biosynthesis" EXACT [] +synonym: "glycosylceramide formation" EXACT [] +synonym: "glycosylceramide synthesis" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:0046477 +name: glycosylceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] +subset: gosubset_prok +synonym: "glycosylceramide breakdown" EXACT [] +synonym: "glycosylceramide catabolism" EXACT [] +synonym: "glycosylceramide degradation" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process +is_a: GO:0019377 ! glycolipid catabolic process +is_a: GO:0046514 ! ceramide catabolic process + +[Term] +id: GO:0046478 +name: lactosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lactosylceramide metabolism" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process + +[Term] +id: GO:0046479 +name: glycosphingolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glycosphingolipid breakdown" EXACT [] +synonym: "glycosphingolipid catabolism" EXACT [] +synonym: "glycosphingolipid degradation" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process +is_a: GO:0019377 ! glycolipid catabolic process +is_a: GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0046480 +name: galactolipid galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184] +synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.184] +synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184] +synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184] +synonym: "galactolipid-galactolipid galactosyltransferase activity" EXACT [EC:2.4.1.184] +synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT [] +synonym: "GGGT activity" EXACT [EC:2.4.1.184] +synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184] +xref: EC:2.4.1.184 +xref: MetaCyc:RXN-1226 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0046481 +name: digalactosyldiacylglycerol synthase +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol = UDP + 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol." [EC:2.4.1.241, MetaCyc:RXN-1225] +synonym: "DGD1" NARROW [] +synonym: "DGD2" NARROW [] +synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241] +synonym: "UDP-galactose-dependent DGDG synthase activity" EXACT [EC:2.4.1.241] +synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" EXACT [EC:2.4.1.241] +synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.241] +synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT [] +xref: EC:2.4.1.241 +xref: MetaCyc:RXN-1225 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0046482 +name: para-aminobenzoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743] +subset: gosubset_prok +synonym: "4-aminobenzoic acid metabolic process" EXACT [] +synonym: "4-aminobenzoic acid metabolism" EXACT [] +synonym: "p-aminobenzoic acid metabolic process" EXACT [] +synonym: "p-aminobenzoic acid metabolism" EXACT [] +synonym: "PABA metabolic process" EXACT [] +synonym: "PABA metabolism" EXACT [] +synonym: "para-aminobenzoic acid metabolism" EXACT [] +synonym: "vitamin Bx metabolic process" EXACT [] +synonym: "vitamin Bx metabolism" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process +is_a: GO:0009308 ! cellular amine metabolic process + +[Term] +id: GO:0046483 +name: heterocycle metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "heterocycle metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0046484 +name: oxazole or thiazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "oxazole or thiazole metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046485 +name: ether lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15337120] +subset: gosubset_prok +synonym: "ether lipid metabolism" EXACT [] +synonym: "plasmalogen metabolic process" NARROW [] +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0046486 +name: glycerolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569] +subset: gosubset_prok +synonym: "glycerolipid metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0046487 +name: glyoxylate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "glyoxylate metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0046488 +name: phosphatidylinositol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylinositol metabolism" EXACT [] +synonym: "PtdIns metabolic process" EXACT [] +synonym: "PtdIns metabolism" EXACT [] +is_a: GO:0030384 ! phosphoinositide metabolic process + +[Term] +id: GO:0046489 +name: phosphoinositide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphoinositide anabolism" EXACT [] +synonym: "phosphoinositide biosynthesis" EXACT [] +synonym: "phosphoinositide formation" EXACT [] +synonym: "phosphoinositide synthesis" EXACT [] +is_a: GO:0030384 ! phosphoinositide metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0046490 +name: isopentenyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "IPP metabolic process" EXACT [] +synonym: "IPP metabolism" EXACT [] +synonym: "isopentenyl diphosphate metabolism" EXACT [] +synonym: "isopentenyl pyrophosphate metabolic process" EXACT [] +synonym: "isopentenyl pyrophosphate metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0046491 +name: L-methylmalonyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the levorotatory isomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-methylmalonyl-CoA metabolism" EXACT [] +is_a: GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0046492 +name: heme b metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25] +subset: gosubset_prok +synonym: "haem b metabolic process" EXACT [] +synonym: "haem b metabolism" EXACT [] +synonym: "heme b metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046493 +name: lipid A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "lipid A metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0046494 +name: rhizobactin 1021 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] +subset: gosubset_prok +synonym: "rhizobactin 1021 metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0046495 +name: nicotinamide riboside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nicotinamide riboside metabolism" EXACT [] +is_a: GO:0019362 ! pyridine nucleotide metabolic process + +[Term] +id: GO:0046496 +name: nicotinamide nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nicotinamide nucleotide metabolism" EXACT [] +is_a: GO:0019362 ! pyridine nucleotide metabolic process + +[Term] +id: GO:0046497 +name: nicotinate nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "nicotinate nucleotide metabolism" EXACT [] +is_a: GO:0019362 ! pyridine nucleotide metabolic process + +[Term] +id: GO:0046498 +name: S-adenosylhomocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-adenosylhomocysteine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0046499 +name: S-adenosylmethioninamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] +subset: gosubset_prok +synonym: "S-adenosylmethioninamine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0009308 ! cellular amine metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046500 +name: S-adenosylmethionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "S-adenosyl methionine metabolic process" EXACT [] +synonym: "S-adenosyl methionine metabolism" EXACT [] +synonym: "S-adenosylmethionine metabolism" EXACT [] +synonym: "SAM metabolic process" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046501 +name: protoporphyrinogen IX metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'. +subset: gosubset_prok +synonym: "protoporphyrinogen IX metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin metabolic process + +[Term] +id: GO:0046502 +name: uroporphyrinogen III metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai] +subset: gosubset_prok +synonym: "uroporphyrinogen III metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin metabolic process + +[Term] +id: GO:0046503 +name: glycerolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] +subset: gosubset_prok +synonym: "glycerolipid breakdown" EXACT [] +synonym: "glycerolipid catabolism" EXACT [] +synonym: "glycerolipid degradation" EXACT [] +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0046504 +name: glycerol ether biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai] +subset: gosubset_prok +synonym: "glycerol ether anabolism" EXACT [] +synonym: "glycerol ether biosynthesis" EXACT [] +synonym: "glycerol ether formation" EXACT [] +synonym: "glycerol ether synthesis" EXACT [] +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046505 +name: sulfolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] +subset: gosubset_prok +synonym: "sulfolipid metabolism" EXACT [] +synonym: "sulpholipid metabolic process" EXACT [] +synonym: "sulpholipid metabolism" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0046506 +name: sulfolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] +subset: gosubset_prok +synonym: "sulfolipid anabolism" EXACT [] +synonym: "sulfolipid biosynthesis" EXACT [] +synonym: "sulfolipid formation" EXACT [] +synonym: "sulfolipid synthesis" EXACT [] +synonym: "sulpholipid biosynthesis" EXACT [] +synonym: "sulpholipid biosynthetic process" EXACT [] +xref: AraCyc:PWYQT-4427 +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046505 ! sulfolipid metabolic process + +[Term] +id: GO:0046507 +name: UDPsulfoquinovose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + SO3(2-) (sulfite) = UDP-6-sulfoquinovose + H2O." [EC:3.13.1.1] +synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT [] +synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" EXACT [EC:3.13.1.1] +synonym: "UDP-sulfoquinovose synthase activity" EXACT [EC:3.13.1.1] +synonym: "UDPsulphoquinovose synthase activity" EXACT [] +xref: EC:3.13.1.1 +xref: MetaCyc:RXN-1223 +is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds + +[Term] +id: GO:0046508 +name: hydrolase activity, acting on carbon-sulfur bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] +subset: gosubset_prok +synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT [] +xref: EC:3.13 +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0046509 +name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + 1,2-diacylglycerol = UDP + 3-beta-D-galactosyl-1,2-diacylglycerol." [EC:2.4.1.46] +synonym: "1-beta-MGDG activity" EXACT [EC:2.4.1.46] +synonym: "1beta-MGDG" RELATED [EC:2.4.1.46] +synonym: "MGDG synthase activity" EXACT [] +synonym: "monogalactosyldiacylglycerol synthase activity" EXACT [] +synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] +synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT [] +synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46] +synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] +xref: EC:2.4.1.46 +xref: MetaCyc:2.4.1.46-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0046510 +name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224] +synonym: "sulfolipid synthase" BROAD [] +synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT [] +xref: MetaCyc:RXN-1224 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0046511 +name: sphinganine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +subset: gosubset_prok +synonym: "dihydrosphingosine biosynthesis" EXACT [] +synonym: "dihydrosphingosine biosynthetic process" EXACT [] +synonym: "sphinganine anabolism" EXACT [] +synonym: "sphinganine biosynthesis" EXACT [] +synonym: "sphinganine formation" EXACT [] +synonym: "sphinganine synthesis" EXACT [] +is_a: GO:0006667 ! sphinganine metabolic process +is_a: GO:0046520 ! sphingoid biosynthetic process + +[Term] +id: GO:0046512 +name: sphingosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingosine anabolism" EXACT [] +synonym: "sphingosine biosynthesis" EXACT [] +synonym: "sphingosine formation" EXACT [] +synonym: "sphingosine synthesis" EXACT [] +is_a: GO:0006670 ! sphingosine metabolic process +is_a: GO:0046520 ! sphingoid biosynthetic process + +[Term] +id: GO:0046513 +name: ceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai] +subset: gosubset_prok +synonym: "ceramide anabolism" EXACT [] +synonym: "ceramide biosynthesis" EXACT [] +synonym: "ceramide formation" EXACT [] +synonym: "ceramide synthesis" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0046520 ! sphingoid biosynthetic process + +[Term] +id: GO:0046514 +name: ceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai] +subset: gosubset_prok +synonym: "ceramide breakdown" EXACT [] +synonym: "ceramide catabolism" EXACT [] +synonym: "ceramide degradation" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0046521 ! sphingoid catabolic process + +[Term] +id: GO:0046516 +name: hypusine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai] +subset: gosubset_prok +synonym: "hypusine metabolism" EXACT [] +is_a: GO:0006575 ! amino acid derivative metabolic process + +[Term] +id: GO:0046517 +name: octamethylcyclotetrasiloxane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "octamethylcyclotetrasiloxane breakdown" EXACT [] +synonym: "octamethylcyclotetrasiloxane catabolism" EXACT [] +synonym: "octamethylcyclotetrasiloxane degradation" EXACT [] +is_a: GO:0046455 ! organosilicon catabolic process +is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process + +[Term] +id: GO:0046518 +name: octamethylcyclotetrasiloxane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] +subset: gosubset_prok +synonym: "octamethylcyclotetrasiloxane metabolism" EXACT [] +is_a: GO:0018945 ! organosilicon metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046519 +name: sphingoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingoid base metabolic process" EXACT [] +synonym: "sphingoid base metabolism" EXACT [] +synonym: "sphingoid metabolism" EXACT [] +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0046520 +name: sphingoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingoid anabolism" EXACT [] +synonym: "sphingoid biosynthesis" EXACT [] +synonym: "sphingoid formation" EXACT [] +synonym: "sphingoid synthesis" EXACT [] +is_a: GO:0046519 ! sphingoid metabolic process +relationship: part_of GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0046521 +name: sphingoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "sphingoid breakdown" EXACT [] +synonym: "sphingoid catabolism" EXACT [] +synonym: "sphingoid degradation" EXACT [] +is_a: GO:0046519 ! sphingoid metabolic process +relationship: part_of GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0046522 +name: S-methyl-5-thioribose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + S5-methyl-5-thio-D-ribose = ADP + S5-methyl-5-thio-D-ribose 1-phosphate." [EC:2.7.1.100] +subset: gosubset_prok +synonym: "5-methylthioribose kinase (phosphorylating)" EXACT [EC:2.7.1.100] +synonym: "5-methylthioribose kinase activity" EXACT [] +synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] +synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100] +synonym: "methylthioribose kinase activity" EXACT [EC:2.7.1.100] +synonym: "MTR kinase activity" EXACT [EC:2.7.1.100] +xref: EC:2.7.1.100 +xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0046523 +name: S-methyl-5-thioribose-1-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylthio-5-deoxy-D-ribose 1-phosphate = 5-methylthio-5-deoxy-D-ribulose 1-phosphate." [EC:5.3.1.23] +subset: gosubset_prok +synonym: "1-phospho-5'-S-methylthioribose isomerase activity" EXACT [EC:5.3.1.23] +synonym: "1-PMTR isomerase activity" EXACT [EC:5.3.1.23] +synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] +synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT [] +synonym: "methylthioribose 1-phosphate isomerase activity" EXACT [EC:5.3.1.23] +synonym: "MTR-1-P isomerase activity" EXACT [EC:5.3.1.23] +synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] +synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23] +synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] +synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23] +xref: EC:5.3.1.23 +xref: MetaCyc:5.3.1.23-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0046524 +name: sucrose-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14] +subset: gosubset_prok +synonym: "SPS" RELATED [EC:2.4.1.14] +synonym: "sucrose 6-phosphate synthase activity" EXACT [EC:2.4.1.14] +synonym: "sucrose phosphate synthetase activity" EXACT [EC:2.4.1.14] +synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] +synonym: "sucrosephosphate-UDP glucosyltransferase activity" EXACT [EC:2.4.1.14] +synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] +synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] +synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] +synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14] +synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14] +xref: EC:2.4.1.14 +xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0046525 +name: xylosylprotein 4-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133] +synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133] +synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] +synonym: "UDP-D-galactose:xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] +synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] +synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT [] +synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133] +synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133] +xref: EC:2.4.1.133 +xref: MetaCyc:2.4.1.133-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0046526 +name: D-xylulose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: xylitol + NAD+ = D-xylulose + NADH + H+." [EC:1.1.1.9] +subset: gosubset_prok +synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9] +xref: EC:1.1.1.9 +xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0046527 +name: glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: EC:2.4.1.- +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0046528 +name: imaginal disc fusion +namespace: biological_process +def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0046529 +name: imaginal disc fusion, thorax closure +namespace: biological_process +def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0046528 ! imaginal disc fusion + +[Term] +id: GO:0046530 +name: photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0007467 +def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "photoreceptor cell differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0046532 +name: regulation of photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0045673 +def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation." [GOC:go_curators] +synonym: "regulation of photoreceptor differentiation" EXACT [] +synonym: "regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0045664 ! regulation of neuron differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046533 +name: negative regulation of photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0045674 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of photoreceptor cell differentiation." [GOC:go_curators] +synonym: "down regulation of photoreceptor cell differentiation" EXACT [] +synonym: "down regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] +synonym: "down-regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +synonym: "downregulation of photoreceptor cell differentiation" EXACT [] +synonym: "downregulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +synonym: "inhibition of photoreceptor cell differentiation" NARROW [] +synonym: "inhibition of photoreceptor differentiation (sensu Endopterygota)" NARROW [] +synonym: "negative regulation of photoreceptor differentiation" EXACT [] +synonym: "negative regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046534 +name: positive regulation of photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0045675 +def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation." [GOC:go_curators] +synonym: "activation of photoreceptor cell differentiation" NARROW [] +synonym: "activation of photoreceptor differentiation (sensu Endopterygota)" NARROW [] +synonym: "positive regulation of photoreceptor differentiation" EXACT [] +synonym: "positive regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +synonym: "stimulation of photoreceptor cell differentiation" NARROW [] +synonym: "stimulation of photoreceptor differentiation (sensu Endopterygota)" NARROW [] +synonym: "up regulation of photoreceptor cell differentiation" EXACT [] +synonym: "up regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] +synonym: "up-regulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +synonym: "upregulation of photoreceptor cell differentiation" EXACT [] +synonym: "upregulation of photoreceptor differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046535 +name: detection of chemical stimulus involved in sensory perception of umami taste +namespace: biological_process +def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, PMID:11894099] +synonym: "perception of umami taste, detection of chemical stimulus" EXACT [] +synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT [] +synonym: "sensory detection of umami taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT [] +synonym: "sensory transduction of umami taste" EXACT [] +synonym: "umami taste detection" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050917 ! sensory perception of umami taste + +[Term] +id: GO:0046536 +name: dosage compensation complex +namespace: cellular_component +def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah] +subset: goslim_pir +is_a: GO:0044427 ! chromosomal part +is_a: GO:0044428 ! nuclear part +relationship: part_of GO:0000803 ! sex chromosome + +[Term] +id: GO:0046537 +name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate without requiring the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] +subset: gosubset_prok +synonym: "PGAM-i" RELATED [EC:5.4.2.1] +is_a: GO:0004619 ! phosphoglycerate mutase activity + +[Term] +id: GO:0046538 +name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] +subset: gosubset_prok +synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" EXACT [EC:5.4.2.1] +synonym: "PGAM-d" RELATED [EC:5.4.2.1] +is_a: GO:0004619 ! phosphoglycerate mutase activity + +[Term] +id: GO:0046539 +name: histamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Nt-methylhistamine." [EC:2.1.1.8] +synonym: "histamine 1-methyltransferase activity" EXACT [EC:2.1.1.8] +synonym: "histamine methyltransferase activity" EXACT [EC:2.1.1.8] +synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8] +synonym: "imidazolemethyltransferase activity" EXACT [EC:2.1.1.8] +synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" EXACT [EC:2.1.1.8] +synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" EXACT [EC:2.1.1.8] +xref: EC:2.1.1.8 +xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity + +[Term] +id: GO:0046540 +name: U4/U6 x U5 tri-snRNP complex +namespace: cellular_component +def: "A complex composed of three small nuclear ribonucleoproteins, snRNP U4, snRNP U6 and snRNP U5." [PMID:11867543] +synonym: "U4/U6 . U5 snRNP complex" EXACT [] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex + +[Term] +id: GO:0046541 +name: saliva secretion +namespace: biological_process +def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [http://cancerweb.ncl.ac.uk/] +synonym: "salivation" EXACT [] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0046542 +name: alpha-factor export +namespace: biological_process +def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai] +comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process. +is_obsolete: true +consider: GO:0015833 + +[Term] +id: GO:0046543 +name: development of secondary female sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045136 ! development of secondary sexual characteristics +relationship: part_of GO:0046660 ! female sex differentiation + +[Term] +id: GO:0046544 +name: development of secondary male sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045136 ! development of secondary sexual characteristics +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0046545 +name: development of primary female sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045137 ! development of primary sexual characteristics +relationship: part_of GO:0046660 ! female sex differentiation + +[Term] +id: GO:0046546 +name: development of primary male sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045137 ! development of primary sexual characteristics +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0046547 +name: trans-aconitate 3-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate." [EC:2.1.1.145] +synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" EXACT [EC:2.1.1.145] +xref: EC:2.1.1.145 +xref: MetaCyc:2.1.1.145-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046548 +name: retinal rod cell development +namespace: biological_process +def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0046549 +name: retinal cone cell development +namespace: biological_process +def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042462 ! eye photoreceptor cell development +relationship: part_of GO:0042670 ! retinal cone cell differentiation + +[Term] +id: GO:0046550 +name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine +namespace: biological_process +def: "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328] +subset: gosubset_prok +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT [] +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT [] +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT [] +xref: RESID:AA0328 +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0046551 +name: retinal cone cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883] +is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment +relationship: part_of GO:0042670 ! retinal cone cell differentiation + +[Term] +id: GO:0046552 +name: photoreceptor cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046553 +name: D-malate dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.83] +synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.83] +synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83] +synonym: "D-malate dehydrogenase activity" EXACT [EC:1.1.1.83] +synonym: "D-malic enzyme" RELATED [EC:1.1.1.83] +xref: EC:1.1.1.83 +xref: MetaCyc:1.1.1.83-RXN +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0046554 +name: malate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82] +subset: gosubset_prok +synonym: "(S)-malate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.82] +synonym: "malate NADP dehydrogenase activity" EXACT [EC:1.1.1.82] +synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.82] +synonym: "NADP malate dehydrogenase activity" EXACT [EC:1.1.1.82] +synonym: "NADP-linked malate dehydrogenase activity" EXACT [EC:1.1.1.82] +synonym: "NADP-malate dehydrogenase activity" EXACT [EC:1.1.1.82] +xref: EC:1.1.1.82 +xref: MetaCyc:MALATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0046555 +name: acetylxylan esterase activity +namespace: molecular_function +def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72] +subset: gosubset_prok +xref: EC:3.1.1.72 +xref: MetaCyc:3.1.1.72-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0046556 +name: alpha-N-arabinofuranosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55] +subset: gosubset_prok +synonym: "alpha-arabinofuranosidase activity" EXACT [EC:3.2.1.55] +synonym: "alpha-arabinosidase activity" EXACT [EC:3.2.1.55] +synonym: "alpha-L-arabinanase activity" EXACT [EC:3.2.1.55] +synonym: "alpha-L-arabinofuranosidase activity" EXACT [] +synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" EXACT [EC:3.2.1.55] +synonym: "alpha-L-arabinofuranoside hydrolase activity" EXACT [EC:3.2.1.55] +synonym: "alpha-L-arabinosidase activity" EXACT [EC:3.2.1.55] +synonym: "arabinofuranosidase activity" EXACT [EC:3.2.1.55] +synonym: "arabinosidase activity" EXACT [EC:3.2.1.55] +synonym: "L-arabinosidase activity" EXACT [EC:3.2.1.55] +synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT [] +xref: EC:3.2.1.55 +xref: MetaCyc:3.2.1.55-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046557 +name: glucan endo-1,6-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 1,6-linkages in 1,6-beta-D-glucans." [EC:3.2.1.75] +synonym: "1,6-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.75] +synonym: "beta-1,6-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.75] +synonym: "beta-1,6-glucan hydrolase activity" EXACT [EC:3.2.1.75] +synonym: "beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] +synonym: "beta-1,6-glucanase-pustulanase activity" EXACT [EC:3.2.1.75] +synonym: "beta-1->6-glucan hydrolase activity" EXACT [EC:3.2.1.75] +synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT [] +synonym: "endo-(1->6)-beta-D-glucanase activity" EXACT [EC:3.2.1.75] +synonym: "endo-1,6-beta-D-glucanase activity" EXACT [EC:3.2.1.75] +synonym: "endo-1,6-beta-glucanase activity" EXACT [EC:3.2.1.75] +synonym: "endo-beta-1,6-glucanase activity" EXACT [EC:3.2.1.75] +xref: EC:3.2.1.75 +xref: MetaCyc:3.2.1.75-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0046558 +name: arabinan endo-1,5-alpha-L-arabinosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in 1,5-arabinans." [EC:3.2.1.99] +subset: gosubset_prok +synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" EXACT [EC:3.2.1.99] +synonym: "endo-1,5-a-L-arabinanase activity" EXACT [] +synonym: "endo-1,5-alpha-L-arabinanase activity" EXACT [EC:3.2.1.99] +synonym: "endo-alpha-1,5-arabanase activity" EXACT [EC:3.2.1.99] +synonym: "endo-arabanase activity" EXACT [EC:3.2.1.99] +xref: EC:3.2.1.99 +xref: MetaCyc:3.2.1.99-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046559 +name: alpha-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139] +subset: gosubset_prok +synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.139] +synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139] +xref: EC:3.2.1.139 +xref: MetaCyc:3.2.1.139-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046560 +name: scytalidopepsin B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32] +comment: This term was made obsolete because it represents a gene product. +synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32] +synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32] +synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32] +synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32] +synonym: "SLB" RELATED [EC:3.4.23.32] +xref: EC:3.4.23.32 +xref: MetaCyc:3.4.23.32-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0046561 +name: penicillopepsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20] +comment: This term was made obsolete because it represents a gene product. +synonym: "acid protease A" EXACT [] +synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20] +synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20] +synonym: "peptidase A activity" BROAD [EC:3.4.23.20] +xref: EC:3.4.23.20 +xref: MetaCyc:3.4.23.20-RXN +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0046562 +name: glucose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a hexose + O2 = a hexno-1,5-lactone + H2O2; includes beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah] +synonym: "beta-D-glucose oxidase activity" EXACT [] +synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" EXACT [EC:1.1.3.4] +synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.4] +synonym: "beta-D-glucose:quinone oxidoreductase activity" EXACT [EC:1.1.3.4] +synonym: "corylophyline" RELATED [EC:1.1.3.4] +synonym: "D-glucose oxidase activity" EXACT [EC:1.1.3.4] +synonym: "D-glucose-1-oxidase activity" EXACT [EC:1.1.3.4] +synonym: "deoxin-1" RELATED [EC:1.1.3.4] +synonym: "glucose aerodehydrogenase activity" EXACT [EC:1.1.3.4] +synonym: "glucose oxyhydrase activity" EXACT [EC:1.1.3.4] +synonym: "GOD activity" RELATED [EC:1.1.3.4] +synonym: "microcid" RELATED [EC:1.1.3.4] +synonym: "penatin" RELATED [EC:1.1.3.4] +xref: EC:1.1.3.4 +xref: MetaCyc:GLUCOSE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0046563 +name: methanol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN] +comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13). +xref: EC:1.1.3.- +xref: MetaCyc:METHANOL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0046564 +name: oxalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxalate = formate + CO2." [EC:4.1.1.2] +subset: gosubset_prok +synonym: "oxalate carboxy-lyase (formate-forming)" EXACT [EC:4.1.1.2] +synonym: "oxalate carboxy-lyase activity" EXACT [EC:4.1.1.2] +xref: EC:4.1.1.2 +xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0046565 +name: 3-dehydroshikimate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate (protocatechuate) + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.-, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN] +xref: EC:4.2.1.- +xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0046566 +name: DOPA dioxygenase activity +namespace: molecular_function +def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071] +synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT [] +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0046567 +name: aphidicolan-16 beta-ol synthase activity +namespace: molecular_function +def: "Catalysis of the formation of aphidicolan-16 beta-ol from geranylgeranyl diphosphate." [PMID:12149019] +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0046568 +name: 3-methylbutanal reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoamyl alcohol (3-methylbutanol) + NADP+ = isovaleraldehyde (3-methylbutanal) + NADPH + H+." [EC:1.1.1.265] +synonym: "3-methylbutanol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.265] +synonym: "3-methylbutyraldehyde reductase activity" EXACT [] +synonym: "isoamyl alcohol oxidase activity" EXACT [] +xref: EC:1.1.1.265 +xref: MetaCyc:1.1.1.265-RXN +is_a: GO:0004032 ! aldehyde reductase activity + +[Term] +id: GO:0046569 +name: glyoxal oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [EC:1.2.3.-, PMID:11733005] +synonym: "GLOX" EXACT [] +xref: EC:1.2.3.- +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0046570 +name: 5-methylthioribulose-1-phosphate 4-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylthioribulose-1-phosphate = 2,3-diketo-5-methylthio-1-phosphopentane + H2O." [MetaCyc:R145-RXN] +xref: MetaCyc:R145-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0046571 +name: aspartate-2-keto-4-methylthiobutyrate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN] +xref: EC:2.6.1.- +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0046572 +name: versicolorin B synthase activity +namespace: molecular_function +def: "Catalysis of the ring closure reaction: versiconal hemiacetal = versicolorin B + H2O." [PMID:8784203] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0046573 +name: lactonohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988] +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0046574 +name: glycuronidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176] +synonym: "glucuronyl hydrolase activity" EXACT [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046575 +name: rhamnogalacturonan acetylesterase activity +namespace: molecular_function +def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485] +is_a: GO:0008126 ! acetylesterase activity + +[Term] +id: GO:0046576 +name: rhamnogalacturonase B activity +namespace: molecular_function +def: "Catalysis of the cleavage of (1,2)-alpha-L-Rhap-(1,4)-alpha-D-GalpA glycosidic linkage, generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076] +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0046577 +name: long-chain-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20] +synonym: "fatty alcohol oxidase activity" EXACT [] +synonym: "fatty alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] +synonym: "long-chain fatty acid oxidase activity" EXACT [EC:1.1.3.20] +synonym: "long-chain fatty alcohol oxidase activity" EXACT [] +synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20] +xref: EC:1.1.3.20 +xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0046578 +name: regulation of Ras protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +relationship: regulates GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0046579 +name: positive regulation of Ras protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] +synonym: "activation of Ras protein signal transduction" NARROW [] +synonym: "stimulation of Ras protein signal transduction" NARROW [] +synonym: "up regulation of Ras protein signal transduction" EXACT [] +synonym: "up-regulation of Ras protein signal transduction" EXACT [] +synonym: "upregulation of Ras protein signal transduction" EXACT [] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction +relationship: positively_regulates GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0046580 +name: negative regulation of Ras protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] +synonym: "down regulation of Ras protein signal transduction" EXACT [] +synonym: "down-regulation of Ras protein signal transduction" EXACT [] +synonym: "downregulation of Ras protein signal transduction" EXACT [] +synonym: "inhibition of Ras protein signal transduction" NARROW [] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction +relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0046581 +name: intercellular canaliculus +namespace: cellular_component +def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0046582 +name: Rap GTPase activator activity +namespace: molecular_function +def: "Increases the rate of GTP hydrolysis by a GTPase of the Rap family." [GOC:mah] +is_a: GO:0005099 ! Ras GTPase activator activity + +[Term] +id: GO:0046583 +name: cation efflux transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "cation efflux permease activity" EXACT [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0046584 +name: enniatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "enniatin metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0050761 ! depsipeptide metabolic process + +[Term] +id: GO:0046585 +name: enniatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "enniatin anabolism" EXACT [] +synonym: "enniatin biosynthesis" EXACT [] +synonym: "enniatin formation" EXACT [] +synonym: "enniatin synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046584 ! enniatin metabolic process +is_a: GO:0050763 ! depsipeptide biosynthetic process + +[Term] +id: GO:0046586 +name: regulation of calcium-dependent cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion + +[Term] +id: GO:0046587 +name: positive regulation of calcium-dependent cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] +synonym: "activation of calcium-dependent cell-cell adhesion" NARROW [] +synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW [] +synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion +relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion + +[Term] +id: GO:0046588 +name: negative regulation of calcium-dependent cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] +synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion +relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion + +[Term] +id: GO:0046589 +name: ribonuclease T1 activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.3] +subset: gosubset_prok +synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:3.1.27.3] +synonym: "binase activity" EXACT [EC:3.1.27.3] +synonym: "guanyl-specific RNase activity" EXACT [EC:3.1.27.3] +synonym: "guanyloribonuclease activity" EXACT [EC:3.1.27.3] +synonym: "ribonuclease C2" RELATED [EC:3.1.27.3] +synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3] +synonym: "ribonuclease F1" EXACT [] +synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" EXACT [EC:3.1.27.3] +synonym: "ribonuclease N1" RELATED [EC:3.1.27.3] +synonym: "ribonuclease N3" RELATED [EC:3.1.27.3] +synonym: "ribonuclease PP1" RELATED [EC:3.1.27.3] +synonym: "ribonuclease SA" RELATED [EC:3.1.27.3] +synonym: "ribonuclease U1" RELATED [EC:3.1.27.3] +synonym: "RNase F1" RELATED [EC:3.1.27.3] +synonym: "RNase G" RELATED [EC:3.1.27.3] +synonym: "RNase N1 activity" EXACT [EC:3.1.27.3] +synonym: "RNase N2 activity" EXACT [EC:3.1.27.3] +synonym: "RNase Sa" RELATED [EC:3.1.27.3] +synonym: "RNase T1" RELATED [EC:3.1.27.3] +synonym: "RNase T1 activity" EXACT [] +xref: EC:3.1.27.3 +xref: MetaCyc:3.1.27.3-RXN +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0046590 +name: embryonic leg morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands." [GOC:bf] +is_a: GO:0030326 ! embryonic limb morphogenesis +is_a: GO:0035110 ! leg morphogenesis + +[Term] +id: GO:0046591 +name: embryonic leg joint morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. Morphogenesis pertains to the creation of form. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824] +is_a: GO:0035111 ! leg joint morphogenesis +relationship: part_of GO:0046590 ! embryonic leg morphogenesis + +[Term] +id: GO:0046592 +name: polyamine oxidase activity +namespace: molecular_function +def: "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380] +synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11] +synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11] +xref: EC:1.5.3.11 +xref: MetaCyc:POLYAMINE-OXIDASE-RXN +xref: Reactome:25469 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0046593 +name: mandelonitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10] +synonym: "(R)-oxynitrilase activity" EXACT [EC:4.1.2.10] +synonym: "D-alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.10] +synonym: "D-oxynitrilase activity" EXACT [EC:4.1.2.10] +synonym: "hydroxynitrile lyase activity" BROAD [] +synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.10] +synonym: "mandelonitrile benzaldehyde-lyase activity" EXACT [EC:4.1.2.10] +xref: EC:4.1.2.10 +xref: MetaCyc:MANDELONITRILE-LYASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0046594 +name: maintenance of pole plasm mRNA location +namespace: biological_process +alt_id: GO:0048122 +def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm." [GOC:bf, GOC:dph, GOC:tb] +synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT [] +synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of pole plasm mRNA localization (sensu Insecta)" EXACT [] +is_a: GO:0051237 ! maintenance of RNA location +relationship: part_of GO:0019094 ! pole plasm mRNA localization + +[Term] +id: GO:0046595 +name: establishment of pole plasm mRNA localization +namespace: biological_process +alt_id: GO:0048121 +def: "Any process by which mRNA is recruited to the oocyte pole plasm." [GOC:bf] +synonym: "establishment of oocyte pole plasm mRNA localization" EXACT [] +synonym: "establishment of pole plasm mRNA localization (sensu Insecta)" EXACT [] +is_a: GO:0051236 ! establishment of RNA localization +relationship: part_of GO:0019094 ! pole plasm mRNA localization + +[Term] +id: GO:0046596 +name: regulation of virion penetration into host cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism +is_a: GO:0050792 ! regulation of viral reproduction +relationship: regulates GO:0019063 ! virion penetration into host cell + +[Term] +id: GO:0046597 +name: negative regulation of virion penetration into host cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb] +synonym: "down regulation of virion penetration into host" EXACT [] +synonym: "down-regulation of virion penetration into host" EXACT [] +synonym: "downregulation of virion penetration into host" EXACT [] +synonym: "inhibition of virion penetration into host" NARROW [] +is_a: GO:0046596 ! regulation of virion penetration into host cell +is_a: GO:0048525 ! negative regulation of viral reproduction +relationship: negatively_regulates GO:0019063 ! virion penetration into host cell + +[Term] +id: GO:0046598 +name: positive regulation of virion penetration into host cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb] +synonym: "activation of virion penetration into host" NARROW [] +synonym: "stimulation of virion penetration into host" NARROW [] +synonym: "up regulation of virion penetration into host" EXACT [] +synonym: "up-regulation of virion penetration into host" EXACT [] +synonym: "upregulation of virion penetration into host" EXACT [] +is_a: GO:0046596 ! regulation of virion penetration into host cell +is_a: GO:0048524 ! positive regulation of viral reproduction +relationship: positively_regulates GO:0019063 ! virion penetration into host cell + +[Term] +id: GO:0046599 +name: regulation of centriole replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai] +is_a: GO:0046605 ! regulation of centrosome cycle +relationship: regulates GO:0007099 ! centriole replication + +[Term] +id: GO:0046600 +name: negative regulation of centriole replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole replication." [GOC:ai] +synonym: "down regulation of centriole replication" EXACT [] +synonym: "down-regulation of centriole replication" EXACT [] +synonym: "downregulation of centriole replication" EXACT [] +synonym: "inhibition of centriole replication" NARROW [] +is_a: GO:0046599 ! regulation of centriole replication +is_a: GO:0046606 ! negative regulation of centrosome cycle +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0007099 ! centriole replication + +[Term] +id: GO:0046601 +name: positive regulation of centriole replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai] +synonym: "activation of centriole replication" NARROW [] +synonym: "stimulation of centriole replication" NARROW [] +synonym: "up regulation of centriole replication" EXACT [] +synonym: "up-regulation of centriole replication" EXACT [] +synonym: "upregulation of centriole replication" EXACT [] +is_a: GO:0046599 ! regulation of centriole replication +is_a: GO:0046607 ! positive regulation of centrosome cycle +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0007099 ! centriole replication + +[Term] +id: GO:0046602 +name: regulation of mitotic centrosome separation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] +is_a: GO:0046605 ! regulation of centrosome cycle +relationship: regulates GO:0007100 ! mitotic centrosome separation + +[Term] +id: GO:0046603 +name: negative regulation of mitotic centrosome separation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation." [GOC:ai] +synonym: "down regulation of mitotic centrosome separation" EXACT [] +synonym: "down-regulation of mitotic centrosome separation" EXACT [] +synonym: "downregulation of mitotic centrosome separation" EXACT [] +synonym: "inhibition of mitotic centrosome separation" NARROW [] +is_a: GO:0046602 ! regulation of mitotic centrosome separation +is_a: GO:0046606 ! negative regulation of centrosome cycle +relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation + +[Term] +id: GO:0046604 +name: positive regulation of mitotic centrosome separation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] +synonym: "activation of mitotic centrosome separation" NARROW [] +synonym: "stimulation of mitotic centrosome separation" NARROW [] +synonym: "up regulation of mitotic centrosome separation" EXACT [] +synonym: "up-regulation of mitotic centrosome separation" EXACT [] +synonym: "upregulation of mitotic centrosome separation" EXACT [] +is_a: GO:0046602 ! regulation of mitotic centrosome separation +is_a: GO:0046607 ! positive regulation of centrosome cycle +relationship: positively_regulates GO:0007100 ! mitotic centrosome separation + +[Term] +id: GO:0046605 +name: regulation of centrosome cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0007098 ! centrosome cycle + +[Term] +id: GO:0046606 +name: negative regulation of centrosome cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai] +synonym: "down regulation of centrosome cycle" EXACT [] +synonym: "down-regulation of centrosome cycle" EXACT [] +synonym: "downregulation of centrosome cycle" EXACT [] +synonym: "inhibition of centrosome cycle" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0046605 ! regulation of centrosome cycle +relationship: negatively_regulates GO:0007098 ! centrosome cycle + +[Term] +id: GO:0046607 +name: positive regulation of centrosome cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai] +synonym: "activation of centrosome cycle" NARROW [] +synonym: "stimulation of centrosome cycle" NARROW [] +synonym: "up regulation of centrosome cycle" EXACT [] +synonym: "up-regulation of centrosome cycle" EXACT [] +synonym: "upregulation of centrosome cycle" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0046605 ! regulation of centrosome cycle +relationship: positively_regulates GO:0007098 ! centrosome cycle + +[Term] +id: GO:0046608 +name: carotenoid isomerase activity +namespace: molecular_function +def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677] +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0046609 +name: voltage-gated sulfate antiporter activity +namespace: molecular_function +synonym: "prestin" NARROW [] +synonym: "voltage gated sulfate antiporter activity" EXACT [] +synonym: "voltage-dependent sulfate antiporter activity" EXACT [] +synonym: "voltage-sensitive sulfate antiporter activity" EXACT [] +synonym: "voltage-sensitive sulphate antiporter activity" EXACT [] +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0046610 +name: lysosomal proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] +synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT [] +is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain +relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex + +[Term] +id: GO:0046611 +name: lysosomal proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] +synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT [] +synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD [] +is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0046612 +name: lysosomal proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] +synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT [] +is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain +relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex + +[Term] +id: GO:0046615 +name: re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449] +comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces. +is_obsolete: true +replaced_by: GO:0000321 + +[Term] +id: GO:0046617 +name: nucleolar size increase (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai] +comment: This term was made obsolete because it does not describe a biological process. +is_obsolete: true +consider: GO:0007571 +consider: GO:0007576 + +[Term] +id: GO:0046618 +name: drug export +namespace: biological_process +def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle." [GOC:go_curators] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0046619 +name: optic placode formation involved in camera-type eye +namespace: biological_process +def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/] +synonym: "optic placode formation (sensu Mammalia)" EXACT [] +synonym: "optic placode formation in camera-type eye" EXACT [] +synonym: "optic placode formation involved in camera-style eye" EXACT [] +is_a: GO:0001743 ! optic placode formation +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0046620 +name: regulation of organ growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] +synonym: "regulation of organ size" EXACT [GOC:tb] +is_a: GO:0040008 ! regulation of growth +relationship: regulates GO:0035265 ! organ growth + +[Term] +id: GO:0046621 +name: negative regulation of organ growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] +synonym: "down regulation of organ size" EXACT [] +synonym: "down-regulation of organ size" EXACT [] +synonym: "downregulation of organ size" EXACT [] +synonym: "inhibition of organ size" NARROW [] +synonym: "negative regulation of organ size" EXACT [GOC:tb] +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:0046620 ! regulation of organ growth +relationship: negatively_regulates GO:0035265 ! organ growth + +[Term] +id: GO:0046622 +name: positive regulation of organ growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] +synonym: "activation of organ size" NARROW [] +synonym: "positive regulation of organ size" EXACT [GOC:tb] +synonym: "stimulation of organ size" NARROW [] +synonym: "up regulation of organ size" EXACT [] +synonym: "up-regulation of organ size" EXACT [] +synonym: "upregulation of organ size" EXACT [] +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:0046620 ! regulation of organ growth +relationship: positively_regulates GO:0035265 ! organ growth + +[Term] +id: GO:0046623 +name: sphingolipid-translocating ATPase activity +namespace: molecular_function +def: "Catalysis of the movement of sphingolipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [GOC:ai, PMID:12034738] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "sphingolipid flippase activity" EXACT [] +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances +is_a: GO:0046624 ! sphingolipid transporter activity + +[Term] +id: GO:0046624 +name: sphingolipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of sphingolipids into, out of, within or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0046625 +name: sphingolipid binding +namespace: molecular_function +def: "Interacting selectively with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0046626 +name: regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "regulation of insulin receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046627 +name: negative regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "down regulation of insulin receptor signaling pathway" EXACT [] +synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] +synonym: "downregulation of insulin receptor signaling pathway" EXACT [] +synonym: "inhibition of insulin receptor signaling pathway" NARROW [] +synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046628 +name: positive regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "activation of insulin receptor signaling pathway" NARROW [] +synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] +synonym: "stimulation of insulin receptor signaling pathway" NARROW [] +synonym: "up regulation of insulin receptor signaling pathway" EXACT [] +synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] +synonym: "upregulation of insulin receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046629 +name: gamma-delta T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] +synonym: "gamma-delta T lymphocyte activation" EXACT [] +synonym: "gamma-delta T-cell activation" EXACT [] +synonym: "gamma-delta T-lymphocyte activation" EXACT [] +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0046630 +name: gamma-delta T cell proliferation +namespace: biological_process +def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai] +synonym: "gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "gamma-delta T-cell proliferation" EXACT [] +synonym: "gamma-delta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation +is_a: GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046631 +name: alpha-beta T cell activation +namespace: biological_process +def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] +synonym: "alpha-beta T lymphocyte activation" EXACT [] +synonym: "alpha-beta T-cell activation" EXACT [] +synonym: "alpha-beta T-lymphocyte activation" EXACT [] +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0046632 +name: alpha-beta T cell differentiation +namespace: biological_process +def: "The process whereby a precursor cell type acquires the specialized features of an alpha-beta T cell." [GOC:ai] +synonym: "alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "alpha-beta T-cell differentiation" EXACT [] +synonym: "alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046633 +name: alpha-beta T cell proliferation +namespace: biological_process +def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai] +synonym: "alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "alpha-beta T-cell proliferation" EXACT [] +synonym: "alpha-beta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046634 +name: regulation of alpha-beta T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] +synonym: "regulation of alpha-beta T lymphocyte activation" EXACT [] +synonym: "regulation of alpha-beta T-cell activation" EXACT [] +synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046635 +name: positive regulation of alpha-beta T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] +synonym: "activation of alpha-beta T cell activation" NARROW [] +synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT [] +synonym: "positive regulation of alpha-beta T-cell activation" EXACT [] +synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT [] +synonym: "stimulation of alpha-beta T cell activation" NARROW [] +synonym: "up regulation of alpha-beta T cell activation" EXACT [] +synonym: "up-regulation of alpha-beta T cell activation" EXACT [] +synonym: "upregulation of alpha-beta T cell activation" EXACT [] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046636 +name: negative regulation of alpha-beta T cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] +synonym: "down regulation of alpha-beta T cell activation" EXACT [] +synonym: "down-regulation of alpha-beta T cell activation" EXACT [] +synonym: "downregulation of alpha-beta T cell activation" EXACT [] +synonym: "inhibition of alpha-beta T cell activation" NARROW [] +synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT [] +synonym: "negative regulation of alpha-beta T-cell activation" EXACT [] +synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT [] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046637 +name: regulation of alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] +synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "regulation of alpha-beta T-cell differentiation" EXACT [] +synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0046638 +name: positive regulation of alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] +synonym: "activation of alpha-beta T cell differentiation" NARROW [] +synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT [] +synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of alpha-beta T cell differentiation" NARROW [] +synonym: "up regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "up-regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "upregulation of alpha-beta T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0046639 +name: negative regulation of alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] +synonym: "down regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "down-regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "downregulation of alpha-beta T cell differentiation" EXACT [] +synonym: "inhibition of alpha-beta T cell differentiation" NARROW [] +synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT [] +synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0046640 +name: regulation of alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] +synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "regulation of alpha-beta T-cell proliferation" EXACT [] +synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0046641 +name: positive regulation of alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] +synonym: "activation of alpha-beta T cell proliferation" NARROW [] +synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT [] +synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of alpha-beta T cell proliferation" NARROW [] +synonym: "up regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "up-regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "upregulation of alpha-beta T cell proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0046642 +name: negative regulation of alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] +synonym: "down regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "down-regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "downregulation of alpha-beta T cell proliferation" EXACT [] +synonym: "inhibition of alpha-beta T cell proliferation" NARROW [] +synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT [] +synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0046643 +name: regulation of gamma-delta T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] +synonym: "regulation of gamma-delta T lymphocyte activation" EXACT [] +synonym: "regulation of gamma-delta T-cell activation" EXACT [] +synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046644 +name: negative regulation of gamma-delta T cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] +synonym: "down regulation of gamma-delta T cell activation" EXACT [] +synonym: "down-regulation of gamma-delta T cell activation" EXACT [] +synonym: "downregulation of gamma-delta T cell activation" EXACT [] +synonym: "inhibition of gamma-delta T cell activation" NARROW [] +synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT [] +synonym: "negative regulation of gamma-delta T-cell activation" EXACT [] +synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT [] +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046645 +name: positive regulation of gamma-delta T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] +synonym: "activation of gamma-delta T cell activation" NARROW [] +synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT [] +synonym: "positive regulation of gamma-delta T-cell activation" EXACT [] +synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT [] +synonym: "stimulation of gamma-delta T cell activation" NARROW [] +synonym: "up regulation of gamma-delta T cell activation" EXACT [] +synonym: "up-regulation of gamma-delta T cell activation" EXACT [] +synonym: "upregulation of gamma-delta T cell activation" EXACT [] +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046646 +name: regulation of gamma-delta T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] +synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "regulation of gamma-delta T-cell proliferation" EXACT [] +synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +relationship: regulates GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0046647 +name: negative regulation of gamma-delta T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] +synonym: "down regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "down-regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "downregulation of gamma-delta T cell proliferation" EXACT [] +synonym: "inhibition of gamma-delta T cell proliferation" NARROW [] +synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT [] +synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation +is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation +relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0046648 +name: positive regulation of gamma-delta T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] +synonym: "activation of gamma-delta T cell proliferation" NARROW [] +synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT [] +synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of gamma-delta T cell proliferation" NARROW [] +synonym: "up regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "up-regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "upregulation of gamma-delta T cell proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation +is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation +relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0046649 +name: lymphocyte activation +namespace: biological_process +def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140] +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0046651 +name: lymphocyte proliferation +namespace: biological_process +def: "The expansion of a lymphocyte population by cell division." [GOC:ai] +is_a: GO:0032943 ! mononuclear cell proliferation +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0046653 +name: tetrahydrofolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin moiety." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tetrahydrofolate metabolism" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process + +[Term] +id: GO:0046654 +name: tetrahydrofolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin moiety." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "tetrahydrofolate anabolism" EXACT [] +synonym: "tetrahydrofolate biosynthesis" EXACT [] +synonym: "tetrahydrofolate formation" EXACT [] +synonym: "tetrahydrofolate synthesis" EXACT [] +xref: MetaCyc:FOLSYN-PWY +xref: MetaCyc:PWY-3742 +is_a: GO:0009396 ! folic acid and derivative biosynthetic process +is_a: GO:0046653 ! tetrahydrofolate metabolic process + +[Term] +id: GO:0046655 +name: folic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "folate metabolic process" EXACT [] +synonym: "folate metabolism" EXACT [] +synonym: "folic acid metabolism" EXACT [] +synonym: "vitamin B9 metabolic process" EXACT [] +synonym: "vitamin B9 metabolism" EXACT [] +synonym: "vitamin M metabolic process" EXACT [] +synonym: "vitamin M metabolism" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0046656 +name: folic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai] +subset: gosubset_prok +synonym: "folate biosynthesis" EXACT [] +synonym: "folate biosynthetic process" EXACT [] +synonym: "folic acid anabolism" EXACT [] +synonym: "folic acid biosynthesis" EXACT [] +synonym: "folic acid formation" EXACT [] +synonym: "folic acid synthesis" EXACT [] +synonym: "vitamin B9 biosynthesis" EXACT [] +synonym: "vitamin B9 biosynthetic process" EXACT [] +synonym: "vitamin M biosynthesis" EXACT [] +synonym: "vitamin M biosynthetic process" EXACT [] +xref: MetaCyc:FOLSYN-PWY +is_a: GO:0009396 ! folic acid and derivative biosynthetic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042559 ! pteridine and derivative biosynthetic process +is_a: GO:0046655 ! folic acid metabolic process + +[Term] +id: GO:0046657 +name: folic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai] +subset: gosubset_prok +synonym: "folate catabolic process" EXACT [] +synonym: "folate catabolism" EXACT [] +synonym: "folic acid breakdown" EXACT [] +synonym: "folic acid catabolism" EXACT [] +synonym: "folic acid degradation" EXACT [] +synonym: "vitamin B9 catabolic process" EXACT [] +synonym: "vitamin B9 catabolism" EXACT [] +synonym: "vitamin M catabolic process" EXACT [] +synonym: "vitamin M catabolism" EXACT [] +is_a: GO:0009397 ! folic acid and derivative catabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042560 ! pteridine and derivative catabolic process +is_a: GO:0046655 ! folic acid metabolic process + +[Term] +id: GO:0046658 +name: anchored to plasma membrane +namespace: cellular_component +def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah] +synonym: "plasma membrane, GPI-anchored" NARROW [] +is_a: GO:0031225 ! anchored to membrane +is_a: GO:0031226 ! intrinsic to plasma membrane + +[Term] +id: GO:0046659 +name: digestive hormone activity +namespace: molecular_function +def: "A hormone that takes part in the digestion process." [GOC:ai] +synonym: "secretin (sensu Mammalia)" NARROW [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0046660 +name: female sex differentiation +namespace: biological_process +def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] +is_a: GO:0007548 ! sex differentiation +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0046661 +name: male sex differentiation +namespace: biological_process +def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] +is_a: GO:0007548 ! sex differentiation +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0046662 +name: regulation of oviposition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai] +is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0018991 ! oviposition + +[Term] +id: GO:0046663 +name: dorsal closure, leading edge cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138] +is_a: GO:0035026 ! leading edge cell differentiation +relationship: part_of GO:0007392 ! initiation of dorsal closure + +[Term] +id: GO:0046664 +name: dorsal closure, amnioserosa morphology change +namespace: biological_process +def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0046665 +name: amnioserosa maintenance +namespace: biological_process +def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf] +is_a: GO:0001894 ! tissue homeostasis +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0046666 +name: retinal cell programmed cell death +namespace: biological_process +def: "Programmed cell death that occurs in the developing retina." [GOC:bf] +synonym: "programmed cell death, retina cells" EXACT [] +synonym: "programmed cell death, retinal cells" EXACT [] +synonym: "retina cell programmed cell death" EXACT [] +synonym: "retina programmed cell death" EXACT [] +synonym: "retinal programmed cell death" EXACT [] +is_a: GO:0010623 ! developmental programmed cell death +relationship: part_of GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0046667 +name: compound eye retinal cell programmed cell death +namespace: biological_process +def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] +synonym: "retina cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +is_a: GO:0046666 ! retinal cell programmed cell death +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0046668 +name: regulation of retinal cell programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] +synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0046666 ! retinal cell programmed cell death + +[Term] +id: GO:0046669 +name: regulation of compound eye retinal cell programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] +synonym: "regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +is_a: GO:0046668 ! regulation of retinal cell programmed cell death +relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death + +[Term] +id: GO:0046670 +name: positive regulation of retinal cell programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] +synonym: "activation of retinal programmed cell death" NARROW [] +synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] +synonym: "stimulation of retinal programmed cell death" NARROW [] +synonym: "up regulation of retinal programmed cell death" EXACT [] +synonym: "up-regulation of retinal programmed cell death" EXACT [] +synonym: "upregulation of retinal programmed cell death" EXACT [] +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0046668 ! regulation of retinal cell programmed cell death +relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death + +[Term] +id: GO:0046671 +name: negative regulation of retinal cell programmed cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] +synonym: "down regulation of retinal programmed cell death" EXACT [] +synonym: "down-regulation of retinal programmed cell death" EXACT [] +synonym: "downregulation of retinal programmed cell death" EXACT [] +synonym: "inhibition of retinal programmed cell death" NARROW [] +synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0046668 ! regulation of retinal cell programmed cell death +relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death + +[Term] +id: GO:0046672 +name: positive regulation of compound eye retinal cell programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] +synonym: "activation of retinal cell programmed cell death (sensu Endopterygota)" NARROW [] +synonym: "positive regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "stimulation of retinal cell programmed cell death (sensu Endopterygota)" NARROW [] +synonym: "up regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "up-regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "upregulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death +is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death +relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death + +[Term] +id: GO:0046673 +name: negative regulation of compound eye retinal cell programmed cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] +synonym: "down regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "down-regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "downregulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "inhibition of retinal cell programmed cell death (sensu Endopterygota)" NARROW [] +synonym: "negative regulation of retina cell programmed cell death (sensu Endopterygota)" EXACT [] +synonym: "negative regulation of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death +is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death +relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death + +[Term] +id: GO:0046674 +name: induction of retinal programmed cell death +namespace: biological_process +def: "A process which directly activates any of the steps required for programmed cell death in the retina." [GOC:ai] +is_a: GO:0012502 ! induction of programmed cell death +is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death + +[Term] +id: GO:0046675 +name: induction of compound eye retinal cell programmed cell death +namespace: biological_process +def: "A process which directly activates any of the steps required for programmed cell death in the compound eye retina." [GOC:ai] +synonym: "induction of retinal cell programmed cell death (sensu Endopterygota)" EXACT [] +is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death +is_a: GO:0046674 ! induction of retinal programmed cell death + +[Term] +id: GO:0046676 +name: negative regulation of insulin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai] +synonym: "down regulation of insulin secretion" EXACT [] +synonym: "down-regulation of insulin secretion" EXACT [] +synonym: "downregulation of insulin secretion" EXACT [] +synonym: "inhibition of insulin secretion" NARROW [] +is_a: GO:0002792 ! negative regulation of peptide secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0050796 ! regulation of insulin secretion +relationship: negatively_regulates GO:0030073 ! insulin secretion + +[Term] +id: GO:0046677 +name: response to antibiotic +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] +subset: gosubset_prok +synonym: "antibiotic susceptibility/resistance" RELATED [] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0046678 +name: response to bacteriocin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "bacteriocin susceptibility/resistance" RELATED [] +is_a: GO:0046677 ! response to antibiotic + +[Term] +id: GO:0046679 +name: response to streptomycin +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [http://cancerweb.ncl.ac.uk/] +synonym: "streptomycin susceptibility/resistance" RELATED [] +is_a: GO:0046677 ! response to antibiotic + +[Term] +id: GO:0046680 +name: response to DDT +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "DDT resistance" RELATED [] +synonym: "DDT susceptibility/resistance" RELATED [] +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046681 +name: response to carbamate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "carbamate resistance" RELATED [] +synonym: "carbamate susceptibility/resistance" RELATED [] +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046682 +name: response to cyclodiene +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099] +synonym: "cyclodiene resistance" RELATED [] +synonym: "cyclodiene susceptibility/resistance" RELATED [] +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046683 +name: response to organophosphorus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "organophosphorus resistance" RELATED [] +synonym: "organophosphorus susceptibility/resistance" RELATED [] +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046684 +name: response to pyrethroid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "pyrethroid resistance" RELATED [] +synonym: "pyrethroid susceptibility/resistance" RELATED [] +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046685 +name: response to arsenic +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "arsenate sensitivity/resistance" RELATED [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0046686 +name: response to cadmium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] +subset: gosubset_prok +synonym: "cadmium sensitivity/resistance" RELATED [] +synonym: "response to cadmium" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046687 +name: response to chromate +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "chromate sensitivity/resistance" RELATED [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0046688 +name: response to copper ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] +subset: gosubset_prok +synonym: "copper sensitivity/resistance" RELATED [] +synonym: "response to copper" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046689 +name: response to mercury ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] +subset: gosubset_prok +synonym: "mercuric sensitivity/resistance" RELATED [] +synonym: "response to mercuric" EXACT [] +synonym: "response to mercury" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046690 +name: response to tellurium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai] +subset: gosubset_prok +synonym: "response to tellurium" EXACT [] +synonym: "tellurium sensitivity/resistance" RELATED [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046691 +name: intracellular canaliculus +namespace: cellular_component +def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10700045] +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0016324 ! apical plasma membrane + +[Term] +id: GO:0046692 +name: sperm competition +namespace: biological_process +def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0046693 +name: sperm storage +namespace: biological_process +def: "The retention of sperm by a female following mating." [PMID:10885514] +synonym: "retention of sperm" EXACT [] +synonym: "sequestering of sperm" EXACT [] +synonym: "sequestration of sperm" EXACT [] +synonym: "sperm retention" EXACT [] +synonym: "sperm sequestering" EXACT [] +synonym: "sperm sequestration" EXACT [] +synonym: "storage of sperm" EXACT [] +is_a: GO:0046692 ! sperm competition + +[Term] +id: GO:0046694 +name: sperm incapacitation +namespace: biological_process +def: "The process by which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373] +is_a: GO:0046692 ! sperm competition + +[Term] +id: GO:0046695 +name: SLIK (SAGA-like) complex +namespace: cellular_component +def: "A protein complex similar to the SAGA complex but with a smaller form of Spt7 and no Spt8. Although little is known about the SLIK complex, evidence suggests involvement of the general amino acid control pathway." [PMID:12101232, PMID:12186975] +comment: See also the cellular component term 'SAGA complex ; GO:0000124'. +synonym: "SAGA (alt) complex" EXACT [] +synonym: "SALSA complex" EXACT [] +synonym: "SLIK/SALSA complex" EXACT [] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0046696 +name: lipopolysaccharide receptor complex +namespace: cellular_component +def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated." [PMID:11706042] +comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of. +synonym: "LPS receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016021 ! integral to membrane + +[Term] +id: GO:0046697 +name: decidualization +namespace: biological_process +def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11133685] +synonym: "decidual cell reaction" EXACT [] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0007565 ! female pregnancy + +[Term] +id: GO:0046700 +name: heterocycle catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] +subset: gosubset_prok +synonym: "heterocycle breakdown" EXACT [] +synonym: "heterocycle catabolism" EXACT [] +synonym: "heterocycle degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046701 +name: insecticide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] +subset: gosubset_prok +synonym: "insecticide breakdown" EXACT [] +synonym: "insecticide catabolism" EXACT [] +synonym: "insecticide degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0017143 ! insecticide metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046702 +name: galactoside 6-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479] +is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity + +[Term] +id: GO:0046703 +name: natural killer cell lectin-like receptor binding +namespace: molecular_function +def: "Interacting selectively with a lectin-like natural killer cell receptor." [GOC:ai] +synonym: "KLRC4 receptor binding" NARROW [] +synonym: "NK cell lectin-like receptor binding" EXACT [] +synonym: "NKG2D receptor binding" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0046704 +name: CDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "CDP metabolism" EXACT [] +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046705 +name: CDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "CDP anabolism" EXACT [] +synonym: "CDP biosynthesis" EXACT [] +synonym: "CDP formation" EXACT [] +synonym: "CDP synthesis" EXACT [] +is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046704 ! CDP metabolic process + +[Term] +id: GO:0046706 +name: CDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "CDP breakdown" EXACT [] +synonym: "CDP catabolism" EXACT [] +synonym: "CDP degradation" EXACT [] +is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process +is_a: GO:0046704 ! CDP metabolic process + +[Term] +id: GO:0046707 +name: IDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "IDP metabolism" EXACT [] +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046708 +name: IDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "IDP anabolism" EXACT [] +synonym: "IDP biosynthesis" EXACT [] +synonym: "IDP formation" EXACT [] +synonym: "IDP synthesis" EXACT [] +is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046707 ! IDP metabolic process + +[Term] +id: GO:0046709 +name: IDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "IDP breakdown" EXACT [] +synonym: "IDP catabolism" EXACT [] +synonym: "IDP degradation" EXACT [] +is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process +is_a: GO:0046707 ! IDP metabolic process + +[Term] +id: GO:0046710 +name: GDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP metabolism" EXACT [] +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046711 +name: GDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP anabolism" EXACT [] +synonym: "GDP biosynthesis" EXACT [] +synonym: "GDP formation" EXACT [] +synonym: "GDP synthesis" EXACT [] +is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046710 ! GDP metabolic process + +[Term] +id: GO:0046712 +name: GDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "GDP breakdown" EXACT [] +synonym: "GDP catabolism" EXACT [] +synonym: "GDP degradation" EXACT [] +is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process +is_a: GO:0046710 ! GDP metabolic process + +[Term] +id: GO:0046713 +name: boron transport +namespace: biological_process +def: "The directed movement of boron into, out of, within or between cells. Boron is a group 13 element, with properties which are borderline between metals and non-metals." [http://www.webelements.com/] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0046714 +name: boron binding +namespace: molecular_function +def: "Interacting selectively with boron, the group 13 element with properties which are borderline between metals and non-metals." [http://www.webelements.com/] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046715 +name: boron transporter activity +namespace: molecular_function +def: "Catalysis of the transport of boron across a membrane against the concentration gradient." [PMID:12447444] +subset: gosubset_prok +synonym: "efflux-type boron transporter" NARROW [] +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0046716 +name: muscle maintenance +namespace: biological_process +def: "The cellular homeostatic process by which a muscle fiber is preserved in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] +synonym: "muscle fiber maintenance" EXACT [GOC:dph, GOC:tb] +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0046717 +name: acid secretion +namespace: biological_process +def: "The regulated release of acid by a cell or group of cells." [GOC:ai] +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0046718 +name: entry of virus into host cell +namespace: biological_process +def: "The process by which a virion enters a host cell, including virion attachment and penetration." [ISBN:0781718325] +synonym: "viral entry into host cell" EXACT [] +xref: Reactome:168270 +xref: Reactome:168272 +xref: Reactome:168286 +is_a: GO:0030260 ! entry into host cell +relationship: part_of GO:0019059 ! initiation of viral infection + +[Term] +id: GO:0046719 +name: regulation of viral protein levels in host cell +namespace: biological_process +def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai] +synonym: "regulation of viral protein levels" EXACT [] +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0046720 +name: citric acid secretion +namespace: biological_process +def: "The regulated release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or group of cells." [GOC:ai] +synonym: "citrate secretion" EXACT [] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046721 +name: formic acid secretion +namespace: biological_process +def: "The regulated release of formic acid, HCOOH, by a cell or group of cells." [GOC:ai] +synonym: "formate secretion" EXACT [] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046722 +name: lactic acid secretion +namespace: biological_process +def: "The regulated release of lactic acid, 2-hydroxypropanoic acid, by a cell or group of cells." [GOC:ai] +synonym: "lactate secretion" EXACT [] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046723 +name: malic acid secretion +namespace: biological_process +def: "The regulated release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or group of cells." [GOC:ai] +synonym: "hydroxysuccinic acid secretion" EXACT [] +synonym: "malate secretion" EXACT [] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046724 +name: oxalic acid secretion +namespace: biological_process +def: "The regulated release of oxalic acid, ethanedioic acid, by a cell or group of cells." [GOC:ai] +synonym: "oxalate secretion" EXACT [] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046725 +name: negative regulation of viral protein levels in host cell +namespace: biological_process +def: "Any process that reduces the levels of viral proteins in a cell." [GOC:ai] +synonym: "down regulation of viral protein levels in host cell" EXACT [] +synonym: "down-regulation of viral protein levels in host cell" EXACT [] +synonym: "downregulation of viral protein levels in host cell" EXACT [] +synonym: "inhibition of viral protein levels in host cell" NARROW [] +synonym: "negative regulation of viral protein levels" EXACT [] +is_a: GO:0046719 ! regulation of viral protein levels in host cell +is_a: GO:0048519 ! negative regulation of biological process + +[Term] +id: GO:0046726 +name: positive regulation of viral protein levels in host cell +namespace: biological_process +def: "Any process that increases the levels of viral proteins in a cell." [GOC:ai] +synonym: "activation of viral protein levels in host cell" NARROW [] +synonym: "positive regulation of viral protein levels" EXACT [] +synonym: "stimulation of viral protein levels in host cell" NARROW [] +synonym: "up regulation of viral protein levels in host cell" EXACT [] +synonym: "up-regulation of viral protein levels in host cell" EXACT [] +synonym: "upregulation of viral protein levels in host cell" EXACT [] +is_a: GO:0046719 ! regulation of viral protein levels in host cell +is_a: GO:0048518 ! positive regulation of biological process + +[Term] +id: GO:0046727 +name: capsomere +namespace: cellular_component +def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "capsomer" EXACT [] +is_a: GO:0044423 ! virion part +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0046729 +name: viral procapsid +namespace: cellular_component +def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272] +is_a: GO:0044423 ! virion part + +[Term] +id: GO:0046730 +name: induction of host immune response by virus +namespace: biological_process +def: "The induction by a virus of an immune response in the host organism." [ISBN:0781802976] +synonym: "activation of host immune response by virus" EXACT [] +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0044416 ! induction by symbiont of host defense response + +[Term] +id: GO:0046731 +name: passive induction of host immune response by virus +namespace: biological_process +def: "The unintentional stimulation by a virus of a host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976] +synonym: "passive activation of host immune response by virus" EXACT [] +synonym: "passive viral induction of host immune response" EXACT [] +is_a: GO:0046730 ! induction of host immune response by virus + +[Term] +id: GO:0046732 +name: active induction of host immune response by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of a host defense response to viral infection." [ISBN:0781802976] +synonym: "active viral induction of host immune response" EXACT [] +xref: Reactome:168277 +xref: Reactome:168865 +xref: Reactome:168878 +is_a: GO:0046730 ! induction of host immune response by virus + +[Term] +id: GO:0046733 +name: passive induction of humoral immune response in host by virus +namespace: biological_process +def: "The unintentional stimulation by a virus of a host humoral defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976] +synonym: "passive viral activation of humoral immune response in host" EXACT [] +synonym: "passive viral induction of humoral immune response in host" EXACT [] +is_a: GO:0046731 ! passive induction of host immune response by virus + +[Term] +id: GO:0046734 +name: passive induction of cell-mediated immune response in host by virus +namespace: biological_process +def: "The unintentional stimulation by a virus of a cell-mediated host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976] +synonym: "passive viral activation of cell-mediated immune response in host" EXACT [] +synonym: "passive viral induction of cell-mediated immune response in host" EXACT [] +is_a: GO:0046731 ! passive induction of host immune response by virus + +[Term] +id: GO:0046735 +name: passive induction of innate immune response in host by virus +namespace: biological_process +def: "The unintentional stimulation by a virus of an innate host defense response to viral infection, as part of the viral infectious cycle." [GOC:go_curators, ISBN:0781802976] +synonym: "passive viral activation of innate immune response in host" EXACT [] +synonym: "passive viral induction of innate immune response in host" EXACT [] +is_a: GO:0046731 ! passive induction of host immune response by virus + +[Term] +id: GO:0046736 +name: active induction of humoral immune response in host by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [ISBN:0781802976] +synonym: "active viral induction of humoral immune response in host" EXACT [] +is_a: GO:0046732 ! active induction of host immune response by virus + +[Term] +id: GO:0046737 +name: active induction of cell-mediated immune response in host by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [ISBN:0781802976] +synonym: "active viral induction of cell-mediated immune response in host" EXACT [] +is_a: GO:0046732 ! active induction of host immune response by virus + +[Term] +id: GO:0046738 +name: active induction of innate immune response in host by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [ISBN:0781802976] +synonym: "active viral induction of innate immune response in host" EXACT [] +is_a: GO:0046732 ! active induction of host immune response by virus + +[Term] +id: GO:0046739 +name: spread of virus within host +namespace: biological_process +def: "The dissemination of infectious virion particles within an infected host organism." [ISBN:0781718325] +synonym: "viral spread within host" EXACT [] +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0044000 ! movement within host + +[Term] +id: GO:0046740 +name: spread of virus within host, cell to cell +namespace: biological_process +def: "The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host cells." [ISBN:0781718325] +synonym: "cell to cell spread of virus within host" EXACT [] +synonym: "viral spread within host, cell to cell" EXACT [] +is_a: GO:0046739 ! spread of virus within host + +[Term] +id: GO:0046741 +name: spread of virus within host, tissue to tissue +namespace: biological_process +def: "The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host tissue." [ISBN:0781718325] +synonym: "tissue to tissue spread of virus within host" EXACT [] +synonym: "viral spread within host, tissue to tissue" EXACT [] +is_a: GO:0046739 ! spread of virus within host + +[Term] +id: GO:0046742 +name: viral capsid transport in host cell nucleus +namespace: biological_process +def: "The directed movement of viral capsid proteins within the nucleus of the host cell." [ISBN:0781718325] +synonym: "nuclear viral capsid transport" EXACT [] +is_a: GO:0046801 ! intracellular transport of viral capsid in host cell + +[Term] +id: GO:0046743 +name: viral capsid transport in host cell cytoplasm +namespace: biological_process +def: "The directed movement of viral capsid proteins within the cytoplasm of the host cell." [ISBN:0781718325, PMID:11581394] +synonym: "cytoplasmic viral capsid transport" EXACT [] +is_a: GO:0016482 ! cytoplasmic transport +is_a: GO:0046801 ! intracellular transport of viral capsid in host cell + +[Term] +id: GO:0046744 +name: viral capsid envelopment +namespace: biological_process +def: "The process by which a capsid acquires a membrane envelope." [ISBN:0781718325] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0046745 +name: viral capsid re-envelopment +namespace: biological_process +def: "The process by which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0781718325] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0046746 +name: virus budding from nuclear membrane during viral capsid re-envelopment +namespace: biological_process +def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] +synonym: "nuclear membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" EXACT [] +is_a: GO:0046745 ! viral capsid re-envelopment +is_a: GO:0046765 ! virus budding from nuclear membrane + +[Term] +id: GO:0046747 +name: virus budding from Golgi membrane during viral capsid re-envelopment +namespace: biological_process +def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] +synonym: "Golgi membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" EXACT [] +is_a: GO:0046745 ! viral capsid re-envelopment +is_a: GO:0046763 ! virus budding from Golgi membrane + +[Term] +id: GO:0046748 +name: virus budding from ER membrane during viral capsid re-envelopment +namespace: biological_process +def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] +synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "ER membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from ER membrane during viral capsid re-envelopment" EXACT [] +is_a: GO:0046745 ! viral capsid re-envelopment +is_a: GO:0046764 ! virus budding from ER membrane + +[Term] +id: GO:0046749 +name: virus budding from nuclear membrane during viral capsid envelopment +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "nuclear membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "viral budding from nuclear membrane during viral capsid envelopment" EXACT [] +is_a: GO:0046744 ! viral capsid envelopment +is_a: GO:0046765 ! virus budding from nuclear membrane + +[Term] +id: GO:0046750 +name: virus budding from Golgi membrane during viral capsid envelopment +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "Golgi membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "viral budding from Golgi membrane during viral capsid envelopment" EXACT [] +is_a: GO:0046744 ! viral capsid envelopment +is_a: GO:0046763 ! virus budding from Golgi membrane + +[Term] +id: GO:0046751 +name: virus budding from ER membrane during viral capsid envelopment +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "ER membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "viral budding from ER membrane during viral capsid envelopment" EXACT [] +is_a: GO:0046744 ! viral capsid envelopment +is_a: GO:0046764 ! virus budding from ER membrane + +[Term] +id: GO:0046752 +name: viral capsid precursor localization in host cell nucleus +namespace: biological_process +def: "Any process by which viral capsid precursors are transported to, or maintained in, a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325] +synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" EXACT [] +synonym: "localization of viral capsid precursors in nucleus" EXACT [] +synonym: "nuclear localization of viral capsid precursors" EXACT [] +is_a: GO:0008104 ! protein localization +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019069 ! viral capsid assembly +relationship: part_of GO:0046719 ! regulation of viral protein levels in host cell + +[Term] +id: GO:0046753 +name: non-lytic viral release +namespace: biological_process +def: "The release of virion particles from the cell that does not result in cell lysis." [ISBN:0072370319] +is_a: GO:0019076 ! release of virus from host + +[Term] +id: GO:0046754 +name: non-lytic viral exocytosis +namespace: biological_process +def: "The exit of the virion particle from the host cell by exocytosis, without causing cell lysis." [ISBN:0072370319] +is_a: GO:0046753 ! non-lytic viral release + +[Term] +id: GO:0046755 +name: non-lytic virus budding +namespace: biological_process +def: "A form of viral release in which the viral particles bud out through cellular membranes without causing cell lysis. It is also a form of viral envelopment." [ISBN:0072370319] +synonym: "non-lytic viral budding" EXACT [] +is_a: GO:0046753 ! non-lytic viral release + +[Term] +id: GO:0046756 +name: lytic viral exocytosis +namespace: biological_process +def: "The exit of the virion particle from the host cell by exocytosis, resulting in cell lysis." [ISBN:0072370319] +is_a: GO:0019077 ! lytic viral release + +[Term] +id: GO:0046757 +name: lytic virus budding from ER membrane +namespace: biological_process +def: "A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] +synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT [] +synonym: "lytic ER membrane viral budding" EXACT [] +synonym: "lytic viral budding from ER membrane" EXACT [] +is_a: GO:0019078 ! lytic viral budding +is_a: GO:0046764 ! virus budding from ER membrane + +[Term] +id: GO:0046758 +name: lytic virus budding from Golgi membrane +namespace: biological_process +def: "A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] +synonym: "lytic Golgi membrane viral budding" EXACT [] +synonym: "lytic viral budding from Golgi membrane" EXACT [] +is_a: GO:0019078 ! lytic viral budding +is_a: GO:0046763 ! virus budding from Golgi membrane + +[Term] +id: GO:0046759 +name: lytic virus budding from plasma membrane +namespace: biological_process +def: "A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] +synonym: "lytic plasma membrane viral budding" EXACT [] +synonym: "lytic viral budding from plasma membrane" EXACT [] +is_a: GO:0019078 ! lytic viral budding +is_a: GO:0046766 ! virus budding from plasma membrane + +[Term] +id: GO:0046760 +name: non-lytic virus budding from Golgi membrane +namespace: biological_process +def: "A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319] +synonym: "non-lytic Golgi membrane viral budding" EXACT [] +synonym: "non-lytic viral budding from Golgi membrane" EXACT [] +is_a: GO:0046755 ! non-lytic virus budding +is_a: GO:0046763 ! virus budding from Golgi membrane + +[Term] +id: GO:0046761 +name: non-lytic virus budding from plasma membrane +namespace: biological_process +def: "A form of viral release in which the nucleocapsid evaginates from the host plasma membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319] +synonym: "non-lytic plasma membrane viral budding" EXACT [] +synonym: "non-lytic viral budding from plasma membrane" EXACT [] +is_a: GO:0046755 ! non-lytic virus budding +is_a: GO:0046766 ! virus budding from plasma membrane + +[Term] +id: GO:0046762 +name: non-lytic virus budding from ER membrane +namespace: biological_process +def: "A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319] +synonym: "non-lytic endoplasmic reticulum membrane viral budding" EXACT [] +synonym: "non-lytic ER membrane viral budding" EXACT [] +synonym: "non-lytic viral budding from ER membrane" EXACT [] +is_a: GO:0046755 ! non-lytic virus budding +is_a: GO:0046764 ! virus budding from ER membrane + +[Term] +id: GO:0046763 +name: virus budding from Golgi membrane +namespace: biological_process +def: "The evagination of the nucleocapsid from the host Golgi membrane system, resulting in envelopment of the virus." [ISBN:0072370319] +synonym: "Golgi membrane viral budding" EXACT [] +synonym: "viral budding from Golgi membrane" EXACT [] +is_a: GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0046764 +name: virus budding from ER membrane +namespace: biological_process +def: "The evagination of the nucleocapsid from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus." [ISBN:0072370319] +synonym: "endoplasmic reticulum membrane viral budding" EXACT [] +synonym: "ER membrane viral budding" EXACT [] +synonym: "viral budding from ER membrane" EXACT [] +is_a: GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0046765 +name: virus budding from nuclear membrane +namespace: biological_process +def: "The evagination of the nucleocapsid from the host nuclear membrane system, resulting in envelopment of the virus." [ISBN:0072370319] +synonym: "nuclear membrane viral budding" EXACT [] +synonym: "viral budding from nuclear membrane" EXACT [] +is_a: GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0046766 +name: virus budding from plasma membrane +namespace: biological_process +def: "The evagination of the nucleocapsid from the host plasma membrane system, resulting in envelopment of the virus." [ISBN:0072370319] +synonym: "plasma membrane viral budding" EXACT [] +synonym: "viral budding from plasma membrane" EXACT [] +xref: Reactome:168860 +is_a: GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0046767 +name: virus budding from plasma membrane during viral capsid envelopment +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "plasma membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "viral budding from plasma membrane during viral capsid envelopment" EXACT [] +is_a: GO:0046744 ! viral capsid envelopment +is_a: GO:0046766 ! virus budding from plasma membrane + +[Term] +id: GO:0046768 +name: virus budding from plasma membrane during viral capsid re-envelopment +namespace: biological_process +def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] +synonym: "plasma membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from plasma membrane during viral capsid re-envelopment" EXACT [] +is_a: GO:0046745 ! viral capsid re-envelopment +is_a: GO:0046766 ! virus budding from plasma membrane + +[Term] +id: GO:0046769 +name: virus budding from inner nuclear membrane during viral capsid re-envelopment +namespace: biological_process +def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] +synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" EXACT [] +is_a: GO:0046746 ! virus budding from nuclear membrane during viral capsid re-envelopment + +[Term] +id: GO:0046770 +name: virus budding from outer nuclear membrane during viral capsid re-envelopment +namespace: biological_process +def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319] +synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT [] +is_a: GO:0046746 ! virus budding from nuclear membrane during viral capsid re-envelopment + +[Term] +id: GO:0046771 +name: virus budding from inner nuclear membrane during viral capsid envelopment +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "inner nuclear membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" EXACT [] +is_a: GO:0046749 ! virus budding from nuclear membrane during viral capsid envelopment + +[Term] +id: GO:0046772 +name: virus budding from outer nuclear membrane during viral capsid envelopment +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "outer nuclear membrane viral budding during viral capsid envelopment" EXACT [] +synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" EXACT [] +is_a: GO:0046749 ! virus budding from nuclear membrane during viral capsid envelopment + +[Term] +id: GO:0046773 +name: suppression by virus of host termination of protein biosynthetic process +namespace: biological_process +def: "Any viral process that inhibits the termination of host cell protein biosynthesis that occurs in response to viral infection." [ISBN:0781718325] +synonym: "negative regulation by virus of host cell protein biosynthesis shutoff" EXACT [] +synonym: "negative regulation by virus of host cell protein biosynthetic process shutoff" EXACT [] +synonym: "viral inhibition of host cell protein biosynthesis shutoff" EXACT [] +synonym: "viral inhibition of host cell protein biosynthetic process shutoff" EXACT [] +synonym: "viral inhibition of termination of host cell protein biosynthesis" EXACT [] +synonym: "viral inhibition of termination of host cell protein biosynthetic process" EXACT [] +synonym: "viral suppression of termination by host of host cell protein biosynthesis" EXACT [] +synonym: "viral suppression of termination by host of host cell protein biosynthetic process" EXACT [] +is_a: GO:0019049 ! evasion of host defenses by virus +is_a: GO:0019054 ! modification by virus of host cellular process + +[Term] +id: GO:0046774 +name: suppression by virus of intracellular interferon activity in host +namespace: biological_process +def: "Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382] +synonym: "negative regulation by virus of intracellular interferon activity" EXACT [] +is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response + +[Term] +id: GO:0046775 +name: suppression by virus of host cytokine production +namespace: biological_process +def: "Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382] +synonym: "negative regulation by virus of host cytokine production" EXACT [] +is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response + +[Term] +id: GO:0046776 +name: suppression by virus of MHC class I cell surface presentation in host +namespace: biological_process +def: "Any viral process that results in the inhibition of presentation of MHC class I antigen-presenting proteins on the host cell surface." [PMID:10859382] +synonym: "major histocompatibility complex" RELATED [] +synonym: "negative regulation by virus of MHC class I cell surface presentation" EXACT [] +is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response + +[Term] +id: GO:0046777 +name: protein amino acid autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +xref: Reactome:75147 +is_a: GO:0006468 ! protein amino acid phosphorylation +is_a: GO:0016540 ! protein autoprocessing + +[Term] +id: GO:0046778 +name: modification by virus of host mRNA processing +namespace: biological_process +def: "Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325] +synonym: "viral perturbation of host mRNA processing" EXACT [] +xref: Reactome:168315 +xref: Reactome:168859 +xref: Reactome:168883 +is_a: GO:0019056 ! modulation by virus of host transcription + +[Term] +id: GO:0046779 +name: suppression by virus of expression of host genes with introns +namespace: biological_process +def: "Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019] +synonym: "negative regulation by virus of expression of host genes with introns" EXACT [] +synonym: "viral inhibition of expression of host genes with introns" EXACT [] +is_a: GO:0019056 ! modulation by virus of host transcription + +[Term] +id: GO:0046780 +name: suppression by virus of host mRNA splicing +namespace: biological_process +def: "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production." [ISBN:0781718325] +synonym: "negative regulation by virus of host mRNA splicing" EXACT [] +synonym: "viral inhibition of host mRNA splicing" EXACT [] +is_a: GO:0046778 ! modification by virus of host mRNA processing + +[Term] +id: GO:0046781 +name: dispersion by virus of host splicing factors +namespace: biological_process +def: "Any viral process that disperses host splicing factors (snRNPs) to prevent host mRNA splicing, thus reducing host protein production." [ISBN:0781718325] +synonym: "viral dispersion of host splicing factors" EXACT [] +is_a: GO:0046778 ! modification by virus of host mRNA processing + +[Term] +id: GO:0046782 +name: regulation of viral transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0050792 ! regulation of viral reproduction +relationship: regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0046783 +name: modification by virus of host polysomes +namespace: biological_process +def: "Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802] +comment: See also the cellular component term 'polysome ; GO:0005844'. +synonym: "viral perturbation of polysomes" EXACT [] +is_a: GO:0019057 ! regulation of host mRNA translation by virus + +[Term] +id: GO:0046784 +name: intronless viral mRNA export from host nucleus +namespace: biological_process +def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019] +synonym: "intronless viral mRNA export from host cell nucleus" EXACT [] +synonym: "intronless viral mRNA export out of nucleus" EXACT [] +synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "intronless viral mRNA-nucleus export" EXACT [] +is_a: GO:0006406 ! mRNA export from nucleus +is_a: GO:0019048 ! virus-host interaction + +[Term] +id: GO:0046785 +name: microtubule polymerization +namespace: biological_process +def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai] +is_a: GO:0031109 ! microtubule polymerization or depolymerization +is_a: GO:0051258 ! protein polymerization + +[Term] +id: GO:0046786 +name: viral replication complex formation and maintenance +namespace: biological_process +def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019079 ! viral genome replication + +[Term] +id: GO:0046787 +name: viral DNA repair +namespace: biological_process +def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325] +is_a: GO:0006281 ! DNA repair +relationship: part_of GO:0019079 ! viral genome replication + +[Term] +id: GO:0046788 +name: egress of virus within host cell +namespace: biological_process +def: "The process of moving the (often) incomplete virion to the cell surface in order to be released from the cell. Egress can involve travel through the endoplasmic reticulum or cytoplasm and will often include final maturation stages of the virion, but it occurs entirely within the cell." [GOC:rh1, ISBN:0781718325] +synonym: "movement of virus within host cell" EXACT [] +synonym: "viral egress" EXACT [] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release + +[Term] +id: GO:0046789 +name: host cell surface receptor binding +namespace: molecular_function +def: "Interacting selectively with a receptor on the host cell surface." [GOC:ai, PMID:11511370] +subset: gosubset_prok +synonym: "cell surface antigen activity, host-interacting" RELATED [] +synonym: "cell surface receptor ligand" RELATED [] +is_a: GO:0005102 ! receptor binding +is_a: GO:0046812 ! host cell surface binding + +[Term] +id: GO:0046790 +name: virion binding +namespace: molecular_function +def: "Interacting selectively with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046791 +name: suppression by virus of host complement neutralization +namespace: biological_process +def: "Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354] +synonym: "negative regulation by virus of host complement neutralization" EXACT [] +is_a: GO:0019053 ! suppression by virus of host extracellular antiviral response + +[Term] +id: GO:0046792 +name: suppression by virus of host cell cycle arrest +namespace: biological_process +def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605] +synonym: "negative regulation by virus of cell cycle arrest" EXACT [] +synonym: "viral inhibition of cell cycle arrest" EXACT [] +is_a: GO:0019055 ! modification by virus of host cell cycle regulation + +[Term] +id: GO:0046793 +name: induction by virus of modification of host RNA polymerase II +namespace: biological_process +def: "The viral induction of modification to the host RNA polymerase II." [PMID:7637000] +synonym: "virus-induced modification of host RNA polymerase II" EXACT [] +is_a: GO:0019056 ! modulation by virus of host transcription + +[Term] +id: GO:0046794 +name: virion transport +namespace: biological_process +def: "The directed movement of a virion into, out of, or within a host cell." [GOC:ai] +subset: goslim_pir +is_a: GO:0006810 ! transport +is_a: GO:0019048 ! virus-host interaction + +[Term] +id: GO:0046795 +name: intracellular virion transport +namespace: biological_process +def: "The directed movement of a virion within a host cell from one location to another." [GOC:ai, PMID:11733033] +is_a: GO:0046794 ! virion transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0046796 +name: viral genome transport in host cell +namespace: biological_process +def: "The directed movement of the viral genome(s) within a host cell." [GOC:ai, PMID:11090159] +xref: Reactome:168271 +xref: Reactome:168274 +xref: Reactome:168297 +xref: Reactome:168310 +xref: Reactome:168317 +xref: Reactome:168333 +xref: Reactome:168337 +xref: Reactome:168857 +xref: Reactome:168880 +xref: Reactome:168893 +xref: Reactome:168984 +is_a: GO:0006810 ! transport +is_a: GO:0019048 ! virus-host interaction + +[Term] +id: GO:0046797 +name: viral procapsid maturation +namespace: biological_process +def: "The period of virion development during which the capsid components form the immature capsid and encapsulate the viral genome; the capsid often undergoes a number of structural alterations during this period." [PMID:10627558] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0046798 +name: viral portal complex +namespace: cellular_component +def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732] +is_a: GO:0043234 ! protein complex +is_a: GO:0044423 ! virion part +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0046799 +name: recruitment of helicase-primase complex to DNA lesions +namespace: biological_process +def: "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0046787 ! viral DNA repair + +[Term] +id: GO:0046800 +name: enhancement of virulence +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354] +comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. +is_obsolete: true + +[Term] +id: GO:0046801 +name: intracellular transport of viral capsid in host cell +namespace: biological_process +def: "The directed movement of viral capsid proteins within the host cell." [GOC:ai, PMID:9188566] +synonym: "intracellular viral capsid transport" EXACT [] +is_a: GO:0019060 ! intracellular transport of viral proteins in host cell +relationship: part_of GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0046802 +name: egress of viral procapsid from host cell nucleus +namespace: biological_process +def: "The exit of the immature viral procapsid from the nucleus of the host cell." [PMID:9601512, PMID:9765421] +synonym: "nuclear egress of viral procapsid" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport +is_a: GO:0046801 ! intracellular transport of viral capsid in host cell + +[Term] +id: GO:0046803 +name: reduction of virulence +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346] +comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. +is_obsolete: true + +[Term] +id: GO:0046804 +name: peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330] +subset: gosubset_prok +synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT [] +xref: RESID:AA0330 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0046805 +name: protein-heme linkage via 1'-L-histidine +namespace: biological_process +def: "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329] +subset: gosubset_prok +synonym: "protein-haem linkage via 1'-L-histidine" EXACT [] +xref: RESID:AA0329 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0046806 +name: viral scaffold +namespace: cellular_component +def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319] +is_a: GO:0043234 ! protein complex +is_a: GO:0044423 ! virion part +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0046807 +name: viral scaffold assembly and maintenance +namespace: biological_process +def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319] +comment: See also the cellular component term 'viral scaffold ; GO:0046806'. +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0046808 +name: assemblon +namespace: cellular_component +def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489] +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0046809 +name: replication compartment +namespace: cellular_component +def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108] +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0046810 +name: host cell extracellular matrix binding +namespace: molecular_function +def: "Interacting selectively with the extracellular matrix of a host cell." [PMID:7996163] +subset: gosubset_prok +is_a: GO:0050840 ! extracellular matrix binding + +[Term] +id: GO:0046811 +name: histone deacetylase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0035033 ! histone deacetylase regulator activity + +[Term] +id: GO:0046812 +name: host cell surface binding +namespace: molecular_function +def: "Interacting selectively with the surface of a host cell." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046813 +name: virion attachment, binding of host cell surface receptor +namespace: biological_process +def: "The process during virion attachment where a virion binds to a host cell receptor, resulting in a conformational change of the virus protein." [ISBN:0879694971] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019062 ! virion attachment to host cell surface receptor + +[Term] +id: GO:0046814 +name: virion attachment, binding of host cell surface coreceptor +namespace: biological_process +def: "The process during virion attachment where a virion binds to a host cell surface receptor after an initial binding event has occurred, resulting in the fusion of the virion and host cell membranes and the initiation of viral entry." [ISBN:0879694971] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019062 ! virion attachment to host cell surface receptor + +[Term] +id: GO:0046815 +name: genome retention in viral capsid +namespace: biological_process +def: "Any process by which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839] +is_a: GO:0022415 ! viral reproductive process +relationship: part_of GO:0019079 ! viral genome replication + +[Term] +id: GO:0046816 +name: virion transport vesicle +namespace: cellular_component +def: "A vesicle used to transport the partial or complete virion between cellular compartments." [PMID:7933124] +is_a: GO:0031982 ! vesicle +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0046817 +name: chemokine receptor antagonist activity +namespace: molecular_function +def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325] +is_a: GO:0048019 ! receptor antagonist activity + +[Term] +id: GO:0046818 +name: dense nuclear body +namespace: cellular_component +def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976] +is_a: GO:0044428 ! nuclear part + +[Term] +id: GO:0046819 +name: protein secretion by the type V secretion system +namespace: biological_process +def: "The process by which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators] +subset: gosubset_prok +synonym: "autotransporter system" EXACT [] +synonym: "protein secretion by the autotransporter system" EXACT [] +synonym: "protein secretion by the type V protein secretion system" EXACT [] +synonym: "type V protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0046820 +name: 4-amino-4-deoxychorismate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate + glutamine = 4-amino-4-deoxychorismic acid + glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [GOC:krc, PMID:11495989, PMID:8346682] +comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. +subset: gosubset_prok +synonym: "ADC synthase activity" EXACT [EC:6.3.5.8] +synonym: "aminodeoxychorismate synthase activity" RELATED [] +synonym: "chorismate:L-glutamine amido-ligase activity" EXACT [EC:6.3.5.8] +synonym: "p-aminobenzoate synthetase" RELATED [] +synonym: "PabB activity" RELATED [EC:6.3.5.8] +synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] +synonym: "para-aminobenzoic acid synthase activity" RELATED [] +xref: EC:6.3.5.8 +xref: MetaCyc:PABASYN-RXN +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0046821 +name: extrachromosomal DNA +namespace: cellular_component +def: "DNA structures that are not part of a chromosome." [GOC:ai] +subset: gosubset_prok +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0046822 +name: regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046823 +name: negative regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] +synonym: "down regulation of nucleocytoplasmic transport" EXACT [] +synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] +synonym: "downregulation of nucleocytoplasmic transport" EXACT [] +synonym: "inhibition of nucleocytoplasmic transport" NARROW [] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046824 +name: positive regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] +synonym: "activation of nucleocytoplasmic transport" NARROW [] +synonym: "stimulation of nucleocytoplasmic transport" NARROW [] +synonym: "up regulation of nucleocytoplasmic transport" EXACT [] +synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] +synonym: "upregulation of nucleocytoplasmic transport" EXACT [] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046825 +name: regulation of protein export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] +synonym: "regulation of protein export from cell nucleus" EXACT [] +synonym: "regulation of protein export out of nucleus" EXACT [] +synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "regulation of protein-nucleus export" EXACT [] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046826 +name: negative regulation of protein export from nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] +synonym: "down regulation of protein export from nucleus" EXACT [] +synonym: "down-regulation of protein export from nucleus" EXACT [] +synonym: "downregulation of protein export from nucleus" EXACT [] +synonym: "inhibition of protein export from nucleus" NARROW [] +synonym: "negative regulation of protein export from cell nucleus" EXACT [] +synonym: "negative regulation of protein export out of nucleus" EXACT [] +synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "negative regulation of protein-nucleus export" EXACT [] +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046825 ! regulation of protein export from nucleus +is_a: GO:0051224 ! negative regulation of protein transport +relationship: negatively_regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046827 +name: positive regulation of protein export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] +synonym: "activation of protein export from nucleus" NARROW [] +synonym: "positive regulation of protein export from cell nucleus" EXACT [] +synonym: "positive regulation of protein export out of nucleus" EXACT [] +synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "positive regulation of protein-nucleus export" EXACT [] +synonym: "stimulation of protein export from nucleus" NARROW [] +synonym: "up regulation of protein export from nucleus" EXACT [] +synonym: "up-regulation of protein export from nucleus" EXACT [] +synonym: "upregulation of protein export from nucleus" EXACT [] +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046825 ! regulation of protein export from nucleus +is_a: GO:0051222 ! positive regulation of protein transport +relationship: positively_regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046828 +name: regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] +synonym: "regulation of RNA import into cell nucleus" EXACT [] +synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of RNA-nucleus import" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046829 +name: negative regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] +synonym: "down regulation of RNA import into nucleus" EXACT [] +synonym: "down-regulation of RNA import into nucleus" EXACT [] +synonym: "downregulation of RNA import into nucleus" EXACT [] +synonym: "inhibition of RNA import into nucleus" NARROW [] +synonym: "negative regulation of RNA import into cell nucleus" EXACT [] +synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of RNA-nucleus import" EXACT [] +is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046828 ! regulation of RNA import into nucleus +relationship: negatively_regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046830 +name: positive regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] +synonym: "activation of RNA import into nucleus" NARROW [] +synonym: "positive regulation of RNA import into cell nucleus" EXACT [] +synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of RNA-nucleus import" EXACT [] +synonym: "stimulation of RNA import into nucleus" NARROW [] +synonym: "up regulation of RNA import into nucleus" EXACT [] +synonym: "up-regulation of RNA import into nucleus" EXACT [] +synonym: "upregulation of RNA import into nucleus" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046828 ! regulation of RNA import into nucleus +relationship: positively_regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046831 +name: regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] +synonym: "regulation of RNA export from cell nucleus" EXACT [] +synonym: "regulation of RNA export out of nucleus" EXACT [] +synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "regulation of RNA-nucleus export" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046832 +name: negative regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] +synonym: "down regulation of RNA export from nucleus" EXACT [] +synonym: "down-regulation of RNA export from nucleus" EXACT [] +synonym: "downregulation of RNA export from nucleus" EXACT [] +synonym: "inhibition of RNA export from nucleus" NARROW [] +synonym: "negative regulation of RNA export from cell nucleus" EXACT [] +synonym: "negative regulation of RNA export out of nucleus" EXACT [] +synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "negative regulation of RNA-nucleus export" EXACT [] +is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046831 ! regulation of RNA export from nucleus +relationship: negatively_regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046833 +name: positive regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] +synonym: "activation of RNA export from nucleus" NARROW [] +synonym: "positive regulation of RNA export from cell nucleus" EXACT [] +synonym: "positive regulation of RNA export out of nucleus" EXACT [] +synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "positive regulation of RNA-nucleus export" EXACT [] +synonym: "stimulation of RNA export from nucleus" NARROW [] +synonym: "up regulation of RNA export from nucleus" EXACT [] +synonym: "up-regulation of RNA export from nucleus" EXACT [] +synonym: "upregulation of RNA export from nucleus" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046831 ! regulation of RNA export from nucleus +relationship: positively_regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046834 +name: lipid phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0016310 ! phosphorylation +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0046835 +name: carbohydrate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0046836 +name: glycolipid transport +namespace: biological_process +def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells." [GOC:ai] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0046838 +name: phosphorylated carbohydrate dephosphorylation +namespace: biological_process +def: "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate moiety attached to it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0016311 ! dephosphorylation + +[Term] +id: GO:0046839 +name: phospholipid dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0016311 ! dephosphorylation +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0046841 +name: trisporic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai] +subset: gosubset_prok +synonym: "trisporic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046842 +name: trisporic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai] +subset: gosubset_prok +synonym: "trisporic acid anabolism" EXACT [] +synonym: "trisporic acid biosynthesis" EXACT [] +synonym: "trisporic acid formation" EXACT [] +synonym: "trisporic acid synthesis" EXACT [] +is_a: GO:0046841 ! trisporic acid metabolic process + +[Term] +id: GO:0046843 +name: dorsal appendage formation +namespace: biological_process +def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007306 ! eggshell chorion formation + +[Term] +id: GO:0046844 +name: micropyle formation +namespace: biological_process +def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007306 ! eggshell chorion formation + +[Term] +id: GO:0046845 +name: branched duct epithelial cell fate determination, open tracheal system +namespace: biological_process +def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] +synonym: "branch cell fate determination (sensu Insecta)" BROAD [] +synonym: "branched duct epithelial cell fate determination (sensu Insecta)" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0046847 +name: filopodium formation +namespace: biological_process +def: "The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon." [GOC:mah] +synonym: "filopodia biosynthesis" EXACT [] +synonym: "filopodia formation" EXACT [] +is_a: GO:0030035 ! microspike biogenesis + +[Term] +id: GO:0046848 +name: hydroxyapatite binding +namespace: molecular_function +def: "Interacting selectively with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentine." [http://cancerweb.ncl.ac.uk/] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046849 +name: bone remodeling +namespace: biological_process +def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [http://cancerweb.ncl.ac.uk/] +synonym: "bone remodelling" EXACT [] +is_a: GO:0048771 ! tissue remodeling + +[Term] +id: GO:0046850 +name: regulation of bone remodeling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai] +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0046849 ! bone remodeling + +[Term] +id: GO:0046851 +name: negative regulation of bone remodeling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling." [GOC:ai] +synonym: "down regulation of bone remodeling" EXACT [] +synonym: "down-regulation of bone remodeling" EXACT [] +synonym: "downregulation of bone remodeling" EXACT [] +synonym: "inhibition of bone remodeling" NARROW [] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:0046850 ! regulation of bone remodeling +relationship: negatively_regulates GO:0046849 ! bone remodeling + +[Term] +id: GO:0046852 +name: positive regulation of bone remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai] +synonym: "activation of bone remodeling" NARROW [] +synonym: "stimulation of bone remodeling" NARROW [] +synonym: "up regulation of bone remodeling" EXACT [] +synonym: "up-regulation of bone remodeling" EXACT [] +synonym: "upregulation of bone remodeling" EXACT [] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:0046850 ! regulation of bone remodeling +relationship: positively_regulates GO:0046849 ! bone remodeling + +[Term] +id: GO:0046853 +name: inositol and derivative phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into inositol or an inositol derivative. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ChEBI:24848, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "myo-inositol and derivative phosphorylation" NARROW [] +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0046835 ! carbohydrate phosphorylation + +[Term] +id: GO:0046854 +name: phosphoinositide phosphorylation +namespace: biological_process +alt_id: GO:0046837 +def: "The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylinositol phosphate biosynthetic process" NARROW [] +synonym: "phosphatidylinositol phosphate phosphorylation" NARROW [] +synonym: "phosphatidylinositol phosphorylation" NARROW [] +synonym: "PIP biosynthesis" NARROW [] +synonym: "PtdInsP biosynthesis" NARROW [] +xref: Reactome:110453 +is_a: GO:0030384 ! phosphoinositide metabolic process +is_a: GO:0046834 ! lipid phosphorylation + +[Term] +id: GO:0046855 +name: inositol phosphate dephosphorylation +namespace: biological_process +def: "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "myo-inositol phosphate dephosphorylation" NARROW [] +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0046838 ! phosphorylated carbohydrate dephosphorylation + +[Term] +id: GO:0046856 +name: phosphoinositide dephosphorylation +namespace: biological_process +alt_id: GO:0046840 +def: "The process of removing one or more phosphate groups from a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phosphatidylinositol dephosphorylation" NARROW [] +synonym: "phosphatidylinositol phosphate catabolic process" NARROW [] +synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW [] +synonym: "PIP catabolism" NARROW [] +synonym: "PtdInsP catabolism" NARROW [] +synonym: "PtdInsP dephosphorylation" NARROW [] +xref: Reactome:110459 +is_a: GO:0030384 ! phosphoinositide metabolic process +is_a: GO:0046839 ! phospholipid dephosphorylation + +[Term] +id: GO:0046857 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +subset: gosubset_prok +xref: EC:1.7.1 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0046858 +name: chlorosome +namespace: cellular_component +def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:14729689, PMID:15298919] +subset: gosubset_prok +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0046859 +name: hydrogenosomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai] +synonym: "hydrogenosome membrane" EXACT [] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044444 ! cytoplasmic part +relationship: part_of GO:0042566 ! hydrogenosome + +[Term] +id: GO:0046860 +name: glycosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a glycosome." [GOC:ai] +is_a: GO:0031090 ! organelle membrane +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0020015 ! glycosome + +[Term] +id: GO:0046861 +name: glyoxysomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai] +synonym: "glyoxysome membrane" EXACT [] +is_a: GO:0031903 ! microbody membrane +is_a: GO:0044438 ! microbody part +relationship: part_of GO:0009514 ! glyoxysome + +[Term] +id: GO:0046862 +name: chromoplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0031898 ! chromoplast envelope + +[Term] +id: GO:0046863 +name: ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity +namespace: molecular_function +def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515] +comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. +synonym: "rubisco activase activity" EXACT [] +synonym: "rubisco activator" EXACT [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0046864 +name: isoprenoid transport +namespace: biological_process +def: "The directed movement of isoprenoids into, out of, within or between cells. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai] +subset: goslim_pir +is_a: GO:0006810 ! transport + +[Term] +id: GO:0046865 +name: terpenoid transport +namespace: biological_process +def: "The directed movement of terpenoids into, out of, within or between cells. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai] +is_a: GO:0046864 ! isoprenoid transport + +[Term] +id: GO:0046866 +name: tetraterpenoid transport +namespace: biological_process +def: "The directed movement of tetraterpenoids into, out of, within or between cells. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai] +is_a: GO:0046865 ! terpenoid transport + +[Term] +id: GO:0046867 +name: carotenoid transport +namespace: biological_process +def: "The directed movement of carotenoids into, out of, within or between cells. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] +is_a: GO:0046866 ! tetraterpenoid transport + +[Term] +id: GO:0046868 +name: mesosome +namespace: cellular_component +def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] +subset: gosubset_prok +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0046869 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331] +subset: gosubset_prok +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT [] +xref: RESID:AA0331 +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0046870 +name: cadmium ion binding +namespace: molecular_function +def: "Interacting selectively with cadmium (Cd) ions." [GOC:ai] +subset: gosubset_prok +synonym: "cadmium binding" EXACT [] +synonym: "copper/cadmium binding" BROAD [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0046871 +name: N-acetylgalactosamine binding +namespace: molecular_function +def: "Interacting selectively with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [ChEBI:28800, GOC:ai, http://cancerweb.ncl.ac.uk/] +synonym: "N-acetylgalactosamine lectin" RELATED [] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0046872 +name: metal ion binding +namespace: molecular_function +def: "Interacting selectively with any metal ion." [GOC:ai] +subset: gosubset_prok +synonym: "heavy metal binding" NARROW [] +synonym: "metal binding" EXACT [] +is_a: GO:0043167 ! ion binding + +[Term] +id: GO:0046873 +name: metal ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai] +subset: gosubset_prok +synonym: "heavy metal ion porter activity" NARROW [] +synonym: "heavy metal ion transporter activity" NARROW [] +synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] +synonym: "heavy metal-exporting ATPase activity" NARROW [] +synonym: "high affinity metal ion uptake transporter activity" NARROW [] +synonym: "low affinity metal ion uptake transporter activity" NARROW [] +is_a: GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0046874 +name: quinolinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] +subset: gosubset_prok +synonym: "quinolinate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046875 +name: ephrin receptor binding +namespace: molecular_function +def: "Interacting selectively with an ephrin receptor." [GOC:ai] +synonym: "Eph receptor binding" EXACT [] +synonym: "ephrin" NARROW [] +synonym: "GPI-linked ephrin" NARROW [] +synonym: "transmembrane ephrin" NARROW [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0046876 +name: 3,4-didehydroretinal binding +namespace: molecular_function +def: "Interacting selectively with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "blue-sensitive opsin" NARROW [] +synonym: "green-sensitive opsin" NARROW [] +synonym: "long-wave-sensitive opsin" NARROW [] +synonym: "opsin" NARROW [] +synonym: "red-sensitive opsin" NARROW [] +synonym: "short-wave-sensitive opsin" NARROW [] +synonym: "UV-sensitive opsin" NARROW [] +synonym: "violet-sensitive opsin" NARROW [] +is_a: GO:0005501 ! retinoid binding + +[Term] +id: GO:0046877 +name: regulation of saliva secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or group of cells." [GOC:ai] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0046541 ! saliva secretion + +[Term] +id: GO:0046878 +name: positive regulation of saliva secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai] +synonym: "activation of saliva secretion" NARROW [] +synonym: "stimulation of saliva secretion" NARROW [] +synonym: "up regulation of saliva secretion" EXACT [] +synonym: "up-regulation of saliva secretion" EXACT [] +synonym: "upregulation of saliva secretion" EXACT [] +is_a: GO:0046877 ! regulation of saliva secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0046541 ! saliva secretion + +[Term] +id: GO:0046879 +name: hormone secretion +namespace: biological_process +def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling +is_a: GO:0009914 ! hormone transport +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0046880 +name: regulation of follicle-stimulating hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] +is_a: GO:0032276 ! regulation of gonadotropin secretion +relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion + +[Term] +id: GO:0046881 +name: positive regulation of follicle-stimulating hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] +synonym: "activation of follicle-stimulating hormone secretion" NARROW [] +synonym: "stimulation of follicle-stimulating hormone secretion" NARROW [] +synonym: "up regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "upregulation of follicle-stimulating hormone secretion" EXACT [] +is_a: GO:0032278 ! positive regulation of gonadotropin secretion +is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion +relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion + +[Term] +id: GO:0046882 +name: negative regulation of follicle-stimulating hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] +synonym: "down regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "downregulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "inhibition of follicle-stimulating hormone secretion" NARROW [] +is_a: GO:0032277 ! negative regulation of gonadotropin secretion +is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion +relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion + +[Term] +id: GO:0046883 +name: regulation of hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0046879 ! hormone secretion + +[Term] +id: GO:0046884 +name: follicle-stimulating hormone secretion +namespace: biological_process +def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "follitropin secretion" EXACT [] +synonym: "FSH secretion" EXACT [] +is_a: GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0046885 +name: regulation of hormone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] +synonym: "regulation of hormone anabolism" EXACT [] +synonym: "regulation of hormone biosynthesis" EXACT [] +synonym: "regulation of hormone formation" EXACT [] +synonym: "regulation of hormone synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0046886 +name: positive regulation of hormone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] +synonym: "activation of hormone biosynthetic process" NARROW [] +synonym: "positive regulation of hormone anabolism" EXACT [] +synonym: "positive regulation of hormone biosynthesis" EXACT [] +synonym: "positive regulation of hormone formation" EXACT [] +synonym: "positive regulation of hormone synthesis" EXACT [] +synonym: "stimulation of hormone biosynthetic process" NARROW [] +synonym: "up regulation of hormone biosynthetic process" EXACT [] +synonym: "up-regulation of hormone biosynthetic process" EXACT [] +synonym: "upregulation of hormone biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +relationship: positively_regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0046887 +name: positive regulation of hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai] +synonym: "activation of hormone secretion" NARROW [] +synonym: "stimulation of hormone secretion" NARROW [] +synonym: "up regulation of hormone secretion" EXACT [] +synonym: "up-regulation of hormone secretion" EXACT [] +synonym: "upregulation of hormone secretion" EXACT [] +is_a: GO:0046883 ! regulation of hormone secretion +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0046879 ! hormone secretion + +[Term] +id: GO:0046888 +name: negative regulation of hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai] +synonym: "down regulation of hormone secretion" EXACT [] +synonym: "down-regulation of hormone secretion" EXACT [] +synonym: "downregulation of hormone secretion" EXACT [] +synonym: "inhibition of hormone secretion" NARROW [] +is_a: GO:0046883 ! regulation of hormone secretion +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0046879 ! hormone secretion + +[Term] +id: GO:0046889 +name: positive regulation of lipid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] +subset: gosubset_prok +synonym: "activation of lipid biosynthetic process" NARROW [] +synonym: "positive regulation of lipid anabolism" EXACT [] +synonym: "positive regulation of lipid biosynthesis" EXACT [] +synonym: "positive regulation of lipid formation" EXACT [] +synonym: "positive regulation of lipid synthesis" EXACT [] +synonym: "stimulation of lipid biosynthetic process" NARROW [] +synonym: "up regulation of lipid biosynthetic process" EXACT [] +synonym: "up-regulation of lipid biosynthetic process" EXACT [] +synonym: "upregulation of lipid biosynthetic process" EXACT [] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: positively_regulates GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0046890 +name: regulation of lipid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of lipid anabolism" EXACT [] +synonym: "regulation of lipid biosynthesis" EXACT [] +synonym: "regulation of lipid formation" EXACT [] +synonym: "regulation of lipid synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: regulates GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0046891 +name: peptidyl-cysteine S-carbamoylation +namespace: biological_process +def: "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332] +subset: gosubset_prok +xref: RESID:AA0332 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0046892 +name: peptidyl-S-carbamoyl-L-cysteine dehydration +namespace: biological_process +def: "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333] +subset: gosubset_prok +synonym: "formation of peptidyl-S-cyanocysteine" EXACT [] +synonym: "formation of peptidyl-serine thiocyanate ester" EXACT [] +xref: RESID:AA0333 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018249 ! protein amino acid dehydration + +[Term] +id: GO:0046893 +name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation +namespace: biological_process +def: "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334] +subset: gosubset_prok +xref: RESID:AA0334 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0046894 +name: enzyme active site formation via S-amidino-L-cysteine +namespace: biological_process +def: "The transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335] +subset: gosubset_prok +xref: RESID:AA0335 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018307 ! enzyme active site formation + +[Term] +id: GO:0046895 +name: N-terminal peptidyl-isoleucine methylation +namespace: biological_process +def: "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336] +subset: gosubset_prok +xref: RESID:AA0336 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018203 ! peptidyl-isoleucine modification + +[Term] +id: GO:0046896 +name: N-terminal peptidyl-leucine methylation +namespace: biological_process +def: "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337] +subset: gosubset_prok +xref: RESID:AA0337 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018204 ! peptidyl-leucine modification + +[Term] +id: GO:0046897 +name: N-terminal peptidyl-tyrosine methylation +namespace: biological_process +def: "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338] +subset: gosubset_prok +xref: RESID:AA0338 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0046898 +name: response to cycloheximide +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [CHEBI:27641, GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "response to actidione" EXACT [] +is_a: GO:0014071 ! response to cycloalkane + +[Term] +id: GO:0046899 +name: nucleoside triphosphate adenylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10] +synonym: "GTP:AMP phosphotransferase" NARROW [] +synonym: "guanosine triphosphate-adenylate kinase" NARROW [] +synonym: "isozyme 3 of adenylate kinase activity" EXACT [EC:2.7.4.10] +synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT [] +synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT [] +synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" EXACT [EC:2.7.4.10] +xref: EC:2.7.4.10 +xref: MetaCyc:2.7.4.10-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0046900 +name: tetrahydrofolylpolyglutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] +subset: gosubset_prok +synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT [] +synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT [] +synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT [] +is_a: GO:0006760 ! folic acid and derivative metabolic process + +[Term] +id: GO:0046901 +name: tetrahydrofolylpolyglutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] +subset: gosubset_prok +synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT [] +synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT [] +synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT [] +synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT [] +synonym: "tetrahydrofolylpolyglutamate formation" EXACT [] +synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT [] +is_a: GO:0009396 ! folic acid and derivative biosynthetic process +is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process + +[Term] +id: GO:0046902 +name: regulation of mitochondrial membrane permeability +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf] +synonym: "regulation of transport across mitochondrial membrane" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0006839 ! mitochondrial transport + +[Term] +id: GO:0046903 +name: secretion +namespace: biological_process +def: "The regulated release of a substance by a cell, a group of cells, or a tissue." [GOC:ai] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0006810 ! transport + +[Term] +id: GO:0046904 +name: calcium oxalate binding +namespace: molecular_function +def: "Interacting selectively with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046905 +name: phytoene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: prephytoene pyrophosphate = phytoene + pyrophosphate." [GOC:ai, PMID:12641468] +comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32. +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0046906 +name: tetrapyrrole binding +namespace: molecular_function +def: "Interacting selectively with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "porphyrin binding" NARROW [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046907 +name: intracellular transport +namespace: biological_process +def: "The directed movement of substances within a cell." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006810 ! transport +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0046908 +name: negative regulation of crystal formation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai] +comment: This term was made obsolete because a more appropriate term was created. +synonym: "negative regulation of mineralization" RELATED [] +is_obsolete: true +replaced_by: GO:0050801 + +[Term] +id: GO:0046909 +name: intermembrane transport +namespace: biological_process +def: "The directed movement of substances between the intracellular membranes of a cell, for example, the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside." [GOC:ai, PMID:10671554] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0046910 +name: pectinesterase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of any pectinesterase enzyme." [GOC:ai, PMID:10880981] +comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'. +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0046911 +name: metal chelating activity +namespace: molecular_function +def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] +subset: gosubset_prok +synonym: "heavy metal chelation" NARROW [] +synonym: "metal chelation" EXACT [] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0046912 +name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl] +subset: gosubset_prok +xref: EC:2.3.3 +is_a: GO:0016746 ! transferase activity, transferring acyl groups + +[Term] +id: GO:0046914 +name: transition metal ion binding +namespace: molecular_function +def: "Interacting selectively with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0043169 ! cation binding +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0046915 +name: transition metal ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0046916 +name: cellular transition metal ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of transition metal ions within a cell or between a cell and its external environment. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0055076 ! transition metal ion homeostasis + +[Term] +id: GO:0046917 +name: triphosphoribosyl-dephospho-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.7.8.25] +subset: gosubset_prok +synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" EXACT [EC:2.7.8.25] +synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [EC:2.7.8.25] +synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT [] +synonym: "CitG activity" RELATED [EC:2.7.8.25] +xref: EC:2.7.8.25 +xref: MetaCyc:2.7.8.25-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0046918 +name: N-terminal peptidyl-glycine N-palmitoylation +namespace: biological_process +def: "The palmitoylation of the N-terminal glycine of proteins to form the derivative N-palmitoyl-glycine." [RESID:AA0339] +subset: gosubset_prok +xref: RESID:AA0339 +is_a: GO:0006500 ! N-terminal protein palmitoylation + +[Term] +id: GO:0046919 +name: pyruvyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0046920 +name: alpha(1,3)-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage." [GOC:ai] +xref: EC:2.4.1.- +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0046921 +name: alpha(1,6)-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,6)-linkage." [GOC:ai] +xref: EC:2.4.1.- +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0046922 +name: peptide-O-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221] +synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.221] +synonym: "GDP-fucose protein O-fucosyltransferase activity" EXACT [EC:2.4.1.221] +synonym: "GDP-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] +synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221] +xref: EC:2.4.1.221 +xref: MetaCyc:2.4.1.221-RXN +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0046923 +name: ER retention sequence binding +namespace: molecular_function +def: "Interacting selectively with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] +synonym: "endoplasmic reticulum retention sequence binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0046924 +name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine +namespace: biological_process +def: "The posttranslational cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340] +subset: gosubset_prok +xref: RESID:AA0340 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0046925 +name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine +namespace: biological_process +def: "The posttranslational cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341] +subset: gosubset_prok +xref: RESID:AA0341 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0046926 +name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine +namespace: biological_process +def: "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342] +subset: gosubset_prok +xref: RESID:AA0342 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0046927 +name: peptidyl-threonine racemization +namespace: biological_process +def: "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888] +subset: gosubset_prok +is_a: GO:0018085 ! peptidyl-L-amino acid racemization +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0046928 +name: regulation of neurotransmitter secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells." [GOC:ai] +is_a: GO:0050804 ! regulation of synaptic transmission +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051588 ! regulation of neurotransmitter transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0046929 +name: negative regulation of neurotransmitter secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] +synonym: "conotoxin activity" NARROW [] +synonym: "down regulation of neurotransmitter secretion" EXACT [] +synonym: "down-regulation of neurotransmitter secretion" EXACT [] +synonym: "downregulation of neurotransmitter secretion" EXACT [] +synonym: "inhibition of neurotransmitter secretion" NARROW [] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051589 ! negative regulation of neurotransmitter transport +relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0046930 +name: pore complex +namespace: cellular_component +def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "channel-forming toxin activity" RELATED [] +synonym: "pore" EXACT [] +synonym: "pore-forming toxin activity" RELATED [] +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0016021 ! integral to membrane + +[Term] +id: GO:0046931 +name: pore complex biogenesis +namespace: biological_process +def: "The formation of a pore complex, a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:ai] +comment: See also the cellular component term 'pore complex ; GO:0046930'. +subset: gosubset_prok +synonym: "channel-forming toxin activity" RELATED [] +synonym: "pore biosynthesis" EXACT [] +synonym: "pore formation" EXACT [] +synonym: "pore-forming toxin activity" RELATED [] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0046932 +name: sodium-transporting ATP synthase activity, rotational mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism." [EC:3.6.3.15, TC:3.A.2.1.2] +synonym: "sodium-translocating F-type ATPase activity" EXACT [] +synonym: "sodium-transporting two-sector ATPase activity" EXACT [] +is_a: GO:0015081 ! sodium ion transmembrane transporter activity + +[Term] +id: GO:0046933 +name: hydrogen ion transporting ATP synthase activity, rotational mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] +subset: gosubset_prok +synonym: "H+-transporting ATP synthase activity" EXACT [EC:3.6.3.14] +synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] +synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] +xref: Reactome:78757 +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity + +[Term] +id: GO:0046934 +name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate." [EC:2.7.1.153] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.153] +synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] +synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153] +xref: EC:2.7.1.153 +xref: MetaCyc:2.7.1.153-RXN +xref: Reactome:78763 +is_a: GO:0035004 ! phosphoinositide 3-kinase activity + +[Term] +id: GO:0046935 +name: 1-phosphatidylinositol-3-kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai] +comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'. +synonym: "phosphatidylinositol 3-kinase regulator activity" EXACT [] +synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW [] +is_a: GO:0035014 ! phosphoinositide 3-kinase regulator activity + +[Term] +id: GO:0046936 +name: deoxyadenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai] +synonym: "deoxyadenosine deaminase reaction" EXACT [] +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0046937 +name: phytochelatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phytochelatin metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0046938 +name: phytochelatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "phytochelatin anabolism" EXACT [] +synonym: "phytochelatin biosynthesis" EXACT [] +synonym: "phytochelatin formation" EXACT [] +synonym: "phytochelatin synthesis" EXACT [] +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0046937 ! phytochelatin metabolic process + +[Term] +id: GO:0046939 +name: nucleotide phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] +subset: gosubset_prok +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0046940 +name: nucleoside monophosphate phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai] +subset: gosubset_prok +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:0046939 ! nucleotide phosphorylation + +[Term] +id: GO:0046941 +name: azetidine-2-carboxylic acid acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200] +xref: EC:2.3.1.- +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0046942 +name: carboxylic acid transport +namespace: biological_process +def: "The directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0046943 +name: carboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005342 ! organic acid transmembrane transporter activity + +[Term] +id: GO:0046944 +name: protein amino acid carbamoylation +namespace: biological_process +def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0046945 +name: N-terminal peptidyl-alanine N-carbamoylation +namespace: biological_process +def: "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343] +subset: gosubset_prok +synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED [] +xref: RESID:AA0343 +is_a: GO:0018194 ! peptidyl-alanine modification +is_a: GO:0046944 ! protein amino acid carbamoylation +is_a: GO:0050990 ! N-terminal protein amino acid carbamoylation + +[Term] +id: GO:0046946 +name: hydroxylysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hydroxylysine metabolism" EXACT [] +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0046947 +name: hydroxylysine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hydroxylysine anabolism" EXACT [] +synonym: "hydroxylysine biosynthesis" EXACT [] +synonym: "hydroxylysine formation" EXACT [] +synonym: "hydroxylysine synthesis" EXACT [] +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process +is_a: GO:0046946 ! hydroxylysine metabolic process + +[Term] +id: GO:0046948 +name: hydroxylysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "hydroxylysine breakdown" EXACT [] +synonym: "hydroxylysine catabolism" EXACT [] +synonym: "hydroxylysine degradation" EXACT [] +is_a: GO:0009068 ! aspartate family amino acid catabolic process +is_a: GO:0046946 ! hydroxylysine metabolic process + +[Term] +id: GO:0046949 +name: acyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "acyl-CoA anabolism" EXACT [] +synonym: "acyl-CoA biosynthesis" EXACT [] +synonym: "acyl-CoA formation" EXACT [] +synonym: "acyl-CoA synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0006637 ! acyl-CoA metabolic process +is_a: GO:0009108 ! coenzyme biosynthetic process + +[Term] +id: GO:0046950 +name: cellular ketone body metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +synonym: "ketone body metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0046951 +name: ketone body biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ketone body anabolism" EXACT [] +synonym: "ketone body biosynthesis" EXACT [] +synonym: "ketone body formation" EXACT [] +synonym: "ketone body synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046950 ! cellular ketone body metabolic process + +[Term] +id: GO:0046952 +name: ketone body catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "ketone body breakdown" EXACT [] +synonym: "ketone body catabolism" EXACT [] +synonym: "ketone body degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0046950 ! cellular ketone body metabolic process + +[Term] +id: GO:0046956 +name: positive phototaxis +namespace: biological_process +alt_id: GO:0046954 +def: "The directed movement of a cell or organism towards a source of light." [GOC:ai] +synonym: "positive phototactic behavior" EXACT [] +synonym: "positive phototactic behaviour" EXACT [] +synonym: "positive taxis in response to light" EXACT [] +is_a: GO:0042331 ! phototaxis +is_a: GO:0052128 ! positive energy taxis + +[Term] +id: GO:0046957 +name: negative phototaxis +namespace: biological_process +alt_id: GO:0046955 +def: "The directed movement of a cell or organism away from a source of light." [GOC:ai] +synonym: "negative phototactic behavior" EXACT [] +synonym: "negative phototactic behaviour" EXACT [] +synonym: "negative taxis in response to light" EXACT [] +is_a: GO:0042331 ! phototaxis +is_a: GO:0052129 ! negative energy taxis + +[Term] +id: GO:0046958 +name: nonassociative learning +namespace: biological_process +def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089] +synonym: "unconditional response" EXACT [] +is_a: GO:0007612 ! learning + +[Term] +id: GO:0046959 +name: habituation +namespace: biological_process +def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] +is_a: GO:0046958 ! nonassociative learning + +[Term] +id: GO:0046960 +name: sensitization +namespace: biological_process +def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089] +is_a: GO:0046958 ! nonassociative learning + +[Term] +id: GO:0046961 +name: hydrogen ion transporting ATPase activity, rotational mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14] +synonym: "ATP synthase activity" BROAD [EC:3.6.3.14] +synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14] +synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14] +synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14] +synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14] +synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14] +synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14] +synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14] +synonym: "F1-ATPase" NARROW [EC:3.6.3.14] +synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14] +synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14] +synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14] +synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14] +synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14] +synonym: "hydrogen ion translocating A-type ATPase activity" NARROW [] +synonym: "hydrogen ion translocating F-type ATPase activity" NARROW [] +synonym: "hydrogen ion translocating V-type ATPase activity" NARROW [] +synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW [] +synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14] +synonym: "proton-transporting ATPase activity, rotational mechanism" EXACT [] +is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0046962 +name: sodium-transporting ATPase activity, rotational mechanism +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism." [EC:3.6.3.15] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "ATP phosphohydrolase (Na+-transporting) activity" EXACT [EC:3.6.3.15] +synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:3.6.3.145] +synonym: "Na(+)-translocating ATPase activity" BROAD [EC:3.6.3.15] +synonym: "Na(+)-transporting two-sector ATPase activity" EXACT [EC:3.6.3.15] +synonym: "Na+-translocating ATPase activity" EXACT [EC:3.6.3.15] +synonym: "Na+-translocating F1Fo-ATPase" NARROW [EC:3.6.3.15] +synonym: "Na+-transporting two-sector ATPase" NARROW [EC:3.6.3.15] +synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT [] +synonym: "sodium-translocating F-type ATPase activity" NARROW [] +synonym: "sodium-translocating V-type ATPase activity" NARROW [] +synonym: "sodium-transporting two-sector ATPase activity" NARROW [] +synonym: "vacuolar-type Na+-ATPase" NARROW [EC:3.6.3.15] +synonym: "vacuolar-type Na+-translocating ATPase" NARROW [EC:3.6.3.15] +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0019829 ! cation-transporting ATPase activity + +[Term] +id: GO:0046963 +name: 3'-phosphoadenosine 5'-phosphosulfate transport +namespace: biological_process +def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT [] +synonym: "PAPS transport" EXACT [] +is_a: GO:0015860 ! purine nucleoside transport + +[Term] +id: GO:0046964 +name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfatefrom one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT [] +synonym: "PAPS transporter activity" EXACT [] +is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity + +[Term] +id: GO:0046965 +name: retinoid X receptor binding +namespace: molecular_function +def: "Interacting selectively with a retinoid X receptor." [GOC:ai] +synonym: "RXR binding" EXACT [] +is_a: GO:0042974 ! retinoic acid receptor binding + +[Term] +id: GO:0046966 +name: thyroid hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a thyroid hormone receptor." [GOC:ai] +synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW [] +is_a: GO:0008134 ! transcription factor binding +is_a: GO:0035257 ! nuclear hormone receptor binding + +[Term] +id: GO:0046967 +name: cytosol to ER transport +namespace: biological_process +def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai] +synonym: "cytosol to endoplasmic reticulum transport" EXACT [] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0046968 +name: peptide antigen transport +namespace: biological_process +def: "The directed movement of a peptide antigen into, out of, within or between cells. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +is_a: GO:0015833 ! peptide transport +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0046969 +name: NAD-dependent histone deacetylase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 9 of the histone H3 protein." [GOC:ai] +is_a: GO:0017136 ! NAD-dependent histone deacetylase activity +is_a: GO:0032129 ! histone deacetylase activity (H3-K9 specific) + +[Term] +id: GO:0046970 +name: NAD-dependent histone deacetylase activity (H4-K16 specific) +namespace: molecular_function +def: "Catalysis of the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [GOC:ai] +is_a: GO:0017136 ! NAD-dependent histone deacetylase activity + +[Term] +id: GO:0046972 +name: histone acetyltransferase activity (H4-K16 specific) +namespace: molecular_function +def: "Catalysis of the addition of an acetyl group onto lysine at position 16 of the histone H4 protein." [GOC:ai] +synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT [] +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0046973 +name: histone lysine N-methyltransferase activity (H3-K24 specific) +namespace: molecular_function +def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai] +comment: This term was made obsolete because there is no lysine at position 24 of histone H3. +is_obsolete: true +consider: GO:0042800 + +[Term] +id: GO:0046974 +name: histone lysine N-methyltransferase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0046975 +name: histone lysine N-methyltransferase activity (H3-K36 specific) +namespace: molecular_function +def: "Catalysis of the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0046976 +name: histone lysine N-methyltransferase activity (H3-K27 specific) +namespace: molecular_function +def: "Catalysis of the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0046977 +name: TAP binding +namespace: molecular_function +def: "Interacting selectively with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046978 +name: TAP1 binding +namespace: molecular_function +def: "Interacting selectively with the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] +is_a: GO:0046977 ! TAP binding + +[Term] +id: GO:0046979 +name: TAP2 binding +namespace: molecular_function +def: "Interacting selectively with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] +is_a: GO:0046977 ! TAP binding + +[Term] +id: GO:0046980 +name: tapasin binding +namespace: molecular_function +def: "Interacting selectively with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046981 +name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651] +synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [] +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0046982 +name: protein heterodimerization activity +namespace: molecular_function +def: "Interacting selectively with a nonidentical protein to form a heterodimer." [GOC:ai] +is_a: GO:0046983 ! protein dimerization activity + +[Term] +id: GO:0046983 +name: protein dimerization activity +namespace: molecular_function +def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046984 +name: regulation of hemoglobin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] +synonym: "regulation of haemoglobin biosynthesis" EXACT [] +synonym: "regulation of haemoglobin biosynthetic process" EXACT [] +synonym: "regulation of hemoglobin anabolism" EXACT [] +synonym: "regulation of hemoglobin biosynthesis" EXACT [] +synonym: "regulation of hemoglobin formation" EXACT [] +synonym: "regulation of hemoglobin synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0042541 ! hemoglobin biosynthetic process + +[Term] +id: GO:0046985 +name: positive regulation of hemoglobin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] +synonym: "activation of hemoglobin biosynthetic process" NARROW [] +synonym: "positive regulation of haemoglobin biosynthesis" EXACT [] +synonym: "positive regulation of haemoglobin biosynthetic process" EXACT [] +synonym: "positive regulation of hemoglobin anabolism" EXACT [] +synonym: "positive regulation of hemoglobin biosynthesis" EXACT [] +synonym: "positive regulation of hemoglobin formation" EXACT [] +synonym: "positive regulation of hemoglobin synthesis" EXACT [] +synonym: "stimulation of hemoglobin biosynthetic process" NARROW [] +synonym: "up regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "up-regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "upregulation of hemoglobin biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process +relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process + +[Term] +id: GO:0046986 +name: negative regulation of hemoglobin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] +synonym: "down regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "down-regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "downregulation of hemoglobin biosynthetic process" EXACT [] +synonym: "inhibition of hemoglobin biosynthetic process" NARROW [] +synonym: "negative regulation of haemoglobin biosynthesis" EXACT [] +synonym: "negative regulation of haemoglobin biosynthetic process" EXACT [] +synonym: "negative regulation of hemoglobin anabolism" EXACT [] +synonym: "negative regulation of hemoglobin biosynthesis" EXACT [] +synonym: "negative regulation of hemoglobin formation" EXACT [] +synonym: "negative regulation of hemoglobin synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process +relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process + +[Term] +id: GO:0046987 +name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570] +synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT [] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0046988 +name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0046989 +name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0046990 +name: N-hydroxyarylamine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN] +subset: gosubset_prok +synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" EXACT [EC:2.3.1.118] +synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118] +synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118] +xref: EC:2.3.1.118 +xref: MetaCyc:2.3.1.118-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0046991 +name: hydroxynitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyronitrile = cyanide + acetone." [EC:4.1.2.39, MetaCyc:4.1.2.39-RXN] +synonym: "(S)-acetone-cyanohydrin lyase activity" EXACT [EC:4.1.2.39] +synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" EXACT [EC:4.1.2.39] +synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" EXACT [EC:4.1.2.39] +synonym: "hydroxynitrile lyase activity" BROAD [] +synonym: "oxynitrilase activity" BROAD [EC:4.1.2.39] +xref: EC:4.1.2.39 +xref: MetaCyc:4.1.2.39-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0046992 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai] +comment: Note that enzymes of class EC:1.21.99.- should also be annotated to this term. +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW [] +xref: EC:1.21 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0046993 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai] +subset: gosubset_prok +xref: EC:1.21.3 +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0046994 +name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl] +subset: gosubset_prok +xref: EC:1.12.5 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0046995 +name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai] +subset: gosubset_prok +xref: EC:1.12.98 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0046996 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah] +xref: EC:1.14.21 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0046997 +name: oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] +subset: gosubset_prok +xref: EC:1.5.8 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0046998 +name: (S)-usnate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-usnic acid + NADH + H+ = NAD+ + 2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-3-hydroxy-6-methyl-cyclohexa-2,4-dienone." [EC:1.1.1.199, MetaCyc:1.1.1.199-RXN] +synonym: "L-usnic acid dehydrogenase activity" EXACT [EC:1.1.1.199] +synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" EXACT [EC:1.1.1.199] +xref: EC:1.1.1.199 +xref: MetaCyc:1.1.1.199-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0046999 +name: regulation of conjugation +namespace: biological_process +def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0000746 ! conjugation + +[Term] +id: GO:0047000 +name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 2-dehydro-3-deoxy-D-gluconate = NADPH + H+ + (4S,5S)-4,5-dehydroxy-2,6-dioxohexanoate." [EC:1.1.1.126, MetaCyc:1.1.1.126-RXN] +synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.126] +synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.126] +xref: EC:1.1.1.126 +xref: MetaCyc:1.1.1.126-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047001 +name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN] +synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.127] +synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" EXACT [EC:1.1.1.127] +synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.127] +synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" EXACT [EC:1.1.1.127] +synonym: "2-keto-3-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.127] +xref: EC:1.1.1.127 +xref: MetaCyc:1.1.1.127-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047002 +name: L-arabinitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + L-arabitol = NADH + H+ + L-ribulose." [EC:1.1.1.13, MetaCyc:1.1.1.13-RXN] +synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT [] +xref: EC:1.1.1.13 +xref: MetaCyc:1.1.1.13-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047003 +name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + dTDP-6-deoxy-L-talose = NADPH + dTDP-4-dehydro-6-deoxy-L-mannose." [EC:1.1.1.134, MetaCyc:1.1.1.134-RXN] +synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" EXACT [EC:1.1.1.134] +synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.134] +synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] +synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134] +xref: EC:1.1.1.134 +xref: MetaCyc:1.1.1.134-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047004 +name: UDP-N-acetylglucosamine 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-D-glucosamine = 2 NADH + 2 H+ + UDP-N-acetyl-2-amino-d-glucuronate." [EC:1.1.1.136, MetaCyc:1.1.1.136-RXN] +synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.136] +synonym: "UDP-GLcNAc dehydrogenase activity" EXACT [EC:1.1.1.136] +synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.136] +synonym: "UDPacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] +synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136] +xref: EC:1.1.1.136 +xref: MetaCyc:1.1.1.136-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047005 +name: 16-alpha-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN] +synonym: "16alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.147] +synonym: "16alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.147] +synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" EXACT [EC:1.1.1.147] +xref: EC:1.1.1.147 +xref: MetaCyc:1.1.1.147-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047006 +name: 20-alpha-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] +subset: gosubset_prok +synonym: "20alpha-HSD" RELATED [EC:1.1.1.149] +synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149] +synonym: "20alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.149] +synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149] +synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" EXACT [EC:1.1.1.149] +xref: EC:1.1.1.149 +xref: MetaCyc:1.1.1.149-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047007 +name: 21-hydroxysteroid dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + pregnan-21-ol = NADH + H+ + pregnan-21-al." [EC:1.1.1.150, MetaCyc:1.1.1.150-RXN] +synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" EXACT [EC:1.1.1.150] +xref: EC:1.1.1.150 +xref: MetaCyc:1.1.1.150-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047008 +name: 21-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + pregnan-21-ol = NADPH + H+ + pregnan-21-al." [EC:1.1.1.151, MetaCyc:1.1.1.151-RXN] +synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.151] +synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.1.1.151] +synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151] +synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" EXACT [EC:1.1.1.151] +synonym: "NADP-21-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.151] +xref: EC:1.1.1.151 +xref: MetaCyc:1.1.1.151-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047009 +name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN] +synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] +synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" EXACT [EC:1.1.1.152] +synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.152] +synonym: "etiocholanolone 3-alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] +synonym: "etiocholanolone 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152] +xref: EC:1.1.1.152 +xref: MetaCyc:1.1.1.152-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047010 +name: hydroxycyclohexanecarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate = NADH + H+ + (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate." [EC:1.1.1.166, MetaCyc:1.1.1.166-RXN] +synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" EXACT [EC:1.1.1.166] +synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.166] +synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.166] +xref: EC:1.1.1.166 +xref: MetaCyc:1.1.1.166-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047011 +name: 2-dehydropantolactone reductase (A-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN] +synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.168] +synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" EXACT [EC:1.1.1.168] +synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] +synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168] +synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] +xref: EC:1.1.1.168 +xref: MetaCyc:1.1.1.168-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047012 +name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN] +synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT [] +synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170] +synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170] +synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] +synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170] +xref: EC:1.1.1.170 +xref: MetaCyc:1.1.1.170-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047013 +name: 12-alpha-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate = NADPH + H+ + 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate." [EC:1.1.1.176, MetaCyc:1.1.1.176-RXN] +subset: gosubset_prok +synonym: "12alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.176] +synonym: "12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176] +synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" EXACT [EC:1.1.1.176] +synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176] +synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176] +xref: EC:1.1.1.176 +xref: MetaCyc:1.1.1.176-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047014 +name: glycerol-3-phosphate 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + glycerol-3-phosphate = NADPH + H+ + glyceraldehyde-3-phosphate." [EC:1.1.1.177, MetaCyc:1.1.1.177-RXN] +synonym: "glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] +synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.177] +synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" EXACT [EC:1.1.1.177] +synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177] +synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.177] +xref: EC:1.1.1.177 +xref: MetaCyc:1.1.1.177-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047015 +name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN] +synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.178] +synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" EXACT [EC:1.1.1.178] +synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.178] +synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.178] +xref: EC:1.1.1.178 +xref: MetaCyc:1.1.1.178-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047016 +name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN] +synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" EXACT [EC:1.1.1.181] +synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181] +synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" EXACT [EC:1.1.1.181] +synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.181] +xref: EC:1.1.1.181 +xref: MetaCyc:1.1.1.181-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047017 +name: prostaglandin-F synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" EXACT [EC:1.1.1.188] +synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" EXACT [EC:1.1.1.188] +synonym: "PGD(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "PGD2 11-ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "PGF synthetase activity" EXACT [EC:1.1.1.188] +synonym: "PGF2alpha synthetase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin 11-keto reductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin 11-ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin D2-ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin F synthase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin F synthetase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-D(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-D(2) 11-reductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-D(2) ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-D2 11-ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-D2 11-reductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-D2 ketoreductase activity" EXACT [EC:1.1.1.188] +synonym: "prostaglandin-F synthetase activity" EXACT [EC:1.1.1.188] +synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" EXACT [EC:1.1.1.188] +synonym: "synthetase, prostaglandin F2alpha" EXACT [EC:1.1.1.188] +xref: EC:1.1.1.188 +xref: MetaCyc:1.1.1.188-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047018 +name: indole-3-acetaldehyde reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + indole-3-ethanol = NADH + H+ + indole acetaldehyde." [EC:1.1.1.190, MetaCyc:1.1.1.190-RXN] +synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] +synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190] +synonym: "indoleacetaldehyde reductase activity" EXACT [EC:1.1.1.190] +xref: EC:1.1.1.190 +xref: MetaCyc:1.1.1.190-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047019 +name: indole-3-acetaldehyde reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + indole-3-ethanol = NADPH + H+ + indole acetaldehyde." [EC:1.1.1.191, MetaCyc:1.1.1.191-RXN] +synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] +synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191] +synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.191] +xref: EC:1.1.1.191 +xref: MetaCyc:1.1.1.191-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047020 +name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.196] +synonym: "15-hydroxy PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] +synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" EXACT [EC:1.1.1.196] +synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.196] +synonym: "dehydrogenase, prostaglandin D2" EXACT [EC:1.1.1.196] +synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] +synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] +synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] +synonym: "NADP-PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196] +synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] +synonym: "prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196] +synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" EXACT [EC:1.1.1.196] +synonym: "prostaglandin-D 15-dehydrogenase (NADP)" EXACT [EC:1.1.1.196] +synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" EXACT [EC:1.1.1.196] +xref: EC:1.1.1.196 +xref: MetaCyc:1.1.1.196-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047021 +name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate = NADPH + H+ + (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate." [EC:1.1.1.197, MetaCyc:1.1.1.197-RXN] +synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.197] +synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] +synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] +synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] +synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.197] +xref: EC:1.1.1.197 +xref: MetaCyc:1.1.1.197-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047022 +name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 7-beta-hydroxysteroid = NADPH + H+ + 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN] +synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" EXACT [EC:1.1.1.201] +synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.201] +synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] +synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201] +xref: EC:1.1.1.201 +xref: MetaCyc:1.1.1.201-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047023 +name: 3(or 17)-alpha-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] +synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.209] +synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.209] +synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.209] +xref: EC:1.1.1.209 +xref: MetaCyc:1.1.1.209-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047024 +name: 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 5-alpha-androstan-3-beta,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADPH + H+." [EC:1.1.1.210, MetaCyc:1.1.1.210-RXN] +synonym: "3-beta-HSD activity" EXACT [EC:1.1.1.210] +synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.210] +synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.210] +synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.210] +synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" EXACT [EC:1.1.1.210] +synonym: "progesterone reductase activity" BROAD [EC:1.1.1.210] +xref: EC:1.1.1.210 +xref: MetaCyc:1.1.1.210-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047025 +name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN] +synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.212] +synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [] +synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT [] +synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.1.1.212] +synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212] +xref: EC:1.1.1.212 +xref: MetaCyc:1.1.1.212-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047026 +name: 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN] +synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" EXACT [EC:1.1.1.213] +synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.213] +xref: EC:1.1.1.213 +xref: MetaCyc:1.1.1.213-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047027 +name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + benzyl (2R,3S)-2-methyl-3-hydroxybutanoate = NADPH + H+ + benzyl 2-methyl-3-oxobutanoate." [EC:1.1.1.217, MetaCyc:1.1.1.217-RXN] +synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.217] +synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.217] +xref: EC:1.1.1.217 +xref: MetaCyc:1.1.1.217-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047028 +name: 6-pyruvoyltetrahydropterin 2'-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN] +subset: gosubset_prok +synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.220] +synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" EXACT [EC:1.1.1.220] +synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" EXACT [EC:1.1.1.220] +synonym: "6-pyruvoyltetrahydropterin reductase activity" EXACT [EC:1.1.1.220] +synonym: "6PPH4(2'-oxo) reductase activity" EXACT [EC:1.1.1.220] +synonym: "pyruvoyl-tetrahydropterin reductase activity" EXACT [EC:1.1.1.220] +xref: EC:1.1.1.220 +xref: MetaCyc:1.1.1.220-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047029 +name: (R)-4-hydroxyphenyllactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate." [EC:1.1.1.222, MetaCyc:1.1.1.222-RXN] +synonym: "(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.222] +synonym: "(R)-aromatic lactate dehydrogenase activity" EXACT [EC:1.1.1.222] +synonym: "D-hydrogenase, D-aryllactate" EXACT [EC:1.1.1.222] +xref: EC:1.1.1.222 +xref: MetaCyc:1.1.1.222-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047030 +name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 4-hydroxycyclohexanecarboxylate = NADH + H+ + 4-oxocyclohexanecarboxylate." [EC:1.1.1.226, MetaCyc:1.1.1.226-RXN] +synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.226] +synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.226] +xref: EC:1.1.1.226 +xref: MetaCyc:1.1.1.226-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047031 +name: diethyl 2-methyl-3-oxosuccinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + diethyl (2R,3R)-2-methyl-3-hydroxysuccinate = NADPH + H+ + diethyl-2-methyl-3-oxosuccinate." [EC:1.1.1.229, MetaCyc:1.1.1.229-RXN] +synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.229] +xref: EC:1.1.1.229 +xref: MetaCyc:1.1.1.229-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047032 +name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 3-alpha-hydroxyglycyrrhetinate = NADPH + H+ + 3-oxoglycyrrhetinate." [EC:1.1.1.230, MetaCyc:1.1.1.230-RXN] +synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" EXACT [EC:1.1.1.230] +synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.230] +xref: EC:1.1.1.230 +xref: MetaCyc:1.1.1.230-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047033 +name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-6,9-alpha-epoxy-11-alpha-hydroxy-15-oxoprosta-5,13-dienoate." [EC:1.1.1.231, MetaCyc:1.1.1.231-RXN] +synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.231] +synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.231] +synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" EXACT [EC:1.1.1.231] +synonym: "PG I2 dehydrogenase activity" EXACT [EC:1.1.1.231] +synonym: "prostacyclin dehydrogenase activity" EXACT [EC:1.1.1.231] +xref: EC:1.1.1.231 +xref: MetaCyc:1.1.1.231-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047034 +name: 15-hydroxyicosatetraenoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN] +synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" EXACT [EC:1.1.1.232] +synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" EXACT [EC:1.1.1.232] +xref: EC:1.1.1.232 +xref: MetaCyc:1.1.1.232-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047035 +name: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + testosterone = NADH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN] +synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239] +synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" EXACT [EC:1.1.1.239] +synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.239] +synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.239] +xref: EC:1.1.1.239 +xref: MetaCyc:1.1.1.239-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047036 +name: codeinone reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + codeine = NADPH + H+ + codeinone." [EC:1.1.1.247, MetaCyc:1.1.1.247-RXN] +synonym: "codeine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.247] +xref: EC:1.1.1.247 +xref: MetaCyc:1.1.1.247-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047037 +name: salutaridine reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + salutaridinol = NADPH + H+ + salutaridine." [EC:1.1.1.248, MetaCyc:1.1.1.248-RXN] +synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.248] +xref: EC:1.1.1.248 +xref: MetaCyc:1.1.1.248-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047038 +name: D-arabinitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + D-arabitol = NADH + H+ + D-ribulose." [EC:1.1.1.250, MetaCyc:1.1.1.250-RXN] +synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" EXACT [EC:1.1.1.250] +synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" EXACT [EC:1.1.1.250] +xref: EC:1.1.1.250 +xref: MetaCyc:1.1.1.250-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047039 +name: tetrahydroxynaphthalene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN] +synonym: "scytalone:NADP+ delta5-oxidoreductase activity" EXACT [EC:1.1.1.252] +synonym: "T4HN reductase activity" EXACT [EC:1.1.1.252] +xref: EC:1.1.1.252 +xref: MetaCyc:1.1.1.252-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047040 +name: pteridine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 NADP+ + tetra-hydro-biopterin = 2 NADPH + 2 H+ + biopterin." [EC:1.1.1.253, MetaCyc:1.1.1.253-RXN] +comment: Note that this function was formerly EC:1.1.1.253. +synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.33] +synonym: "dihydrobiopterin reduction" RELATED [] +synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e] +synonym: "PTR1" RELATED [EC:1.5.1.33] +synonym: "ptr1 activity" NARROW [EC:1.5.1.33e] +xref: EC:1.5.1.33 +xref: MetaCyc:1.1.1.253-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047041 +name: (S)-carnitine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + L-carnitine = NADH + H+ + 3-dehydrocarnitine." [EC:1.1.1.254, MetaCyc:1.1.1.254-RXN] +synonym: "(S)-carnitine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.254] +synonym: "D-carnitine dehydrogenase activity" EXACT [EC:1.1.1.254] +xref: EC:1.1.1.254 +xref: MetaCyc:1.1.1.254-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047042 +name: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN] +subset: gosubset_prok +synonym: "3-alpha-HSD activity" EXACT [EC:1.1.1.50] +synonym: "3alpha-HSD" RELATED [EC:1.1.1.50] +synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" EXACT [EC:1.1.1.50] +synonym: "3alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.50] +synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.50] +synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50] +synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50] +xref: EC:1.1.1.50 +xref: MetaCyc:1.1.1.50-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047043 +name: 3-alpha-hydroxycholanate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-cholanate = NADH + H+ + 3-oxo-5-beta-cholanate." [EC:1.1.1.52, MetaCyc:1.1.1.52-RXN] +synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.52] +synonym: "3alpha-hydroxycholanate dehydrogenase activity" EXACT [EC:1.1.1.52] +synonym: "alpha-hydroxy-cholanate dehydrogenase activity" EXACT [EC:1.1.1.52] +xref: EC:1.1.1.52 +xref: MetaCyc:1.1.1.52-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047044 +name: 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] +subset: gosubset_prok +synonym: "(R)-20-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] +synonym: "20beta-HSD" RELATED [EC:1.1.1.53] +synonym: "20beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] +synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] +synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.53] +synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" EXACT [EC:1.1.1.53] +synonym: "cortisone reductase activity" EXACT [EC:1.1.1.53] +synonym: "dehydrogenase, 20beta-hydroxy steroid" EXACT [EC:1.1.1.53] +synonym: "delta4-3-ketosteroid hydrogenase activity" EXACT [EC:1.1.1.53] +synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53] +xref: EC:1.1.1.53 +xref: MetaCyc:1.1.1.53-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047045 +name: testosterone 17-beta-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] +synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64] +synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" EXACT [EC:1.1.1.64] +synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" EXACT [EC:1.1.1.64] +synonym: "testosterone 17beta-dehydrogenase (NADP+)" EXACT [EC:1.1.1.64] +xref: EC:1.1.1.64 +xref: MetaCyc:1.1.1.64-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047046 +name: homoisocitrate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0047984 +def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN] +comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical. +synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] +synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] +synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] +synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" EXACT [EC:1.1.1.87] +synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT [] +synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87] +synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87] +synonym: "homoisocitric dehydrogenase activity" EXACT [EC:1.1.1.87] +xref: EC:1.1.1.87 +xref: MetaCyc:1.1.1.87-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047047 +name: oxaloglycolate reductase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN] +synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" EXACT [EC:1.1.1.92] +xref: EC:1.1.1.92 +xref: MetaCyc:1.1.1.92-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047048 +name: 3-hydroxybenzyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 3-hydroxybenzyl alcohol = NADPH + H+ + 3-hydroxybenzaldehyde." [EC:1.1.1.97, MetaCyc:1.1.1.97-RXN] +synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.97] +synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" EXACT [EC:1.1.1.97] +synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.97] +synonym: "m-hydroxybenzylalcohol dehydrogenase activity" EXACT [EC:1.1.1.97] +xref: EC:1.1.1.97 +xref: MetaCyc:1.1.1.97-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047049 +name: (R)-2-hydroxy-fatty-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + R-2-hydroxystearate = NADH + H+ + 2-oxostearate." [EC:1.1.1.98, MetaCyc:1.1.1.98-RXN] +synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.98] +synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98] +synonym: "D-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.98] +xref: EC:1.1.1.98 +xref: MetaCyc:1.1.1.98-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047050 +name: (S)-2-hydroxy-fatty-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (S)-2-hydroxystearate = NADH + H+ + 2-oxostearate." [EC:1.1.1.99, MetaCyc:1.1.1.99-RXN] +synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.99] +synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99] +synonym: "dehydrogenase, L-2-hydroxy fatty acid" EXACT [EC:1.1.1.99] +synonym: "L-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.99] +xref: EC:1.1.1.99 +xref: MetaCyc:1.1.1.99-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047051 +name: D-lactate dehydrogenase (cytochrome c-553) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate." [EC:1.1.2.5, MetaCyc:1.1.2.5-RXN] +synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5] +xref: EC:1.1.2.5 +xref: MetaCyc:1.1.2.5-RXN +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0047052 +name: (S)-stylopine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + S-cheilanthifoline = 2 H2O + NADP+ + S-stylopine." [EC:1.14.21.1, MetaCyc:1.1.3.32-RXN] +synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.1] +synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.1] +xref: EC:1.14.21.1 +xref: MetaCyc:1.1.3.32-RXN +is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated + +[Term] +id: GO:0047053 +name: (S)-cheilanthifoline synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + S-scoulerine = 2 H2O + NADP+ + S-cheilanthifoline." [EC:1.14.21.2, MetaCyc:1.14.21.2-RXN] +synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT [] +synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.2] +xref: EC:1.14.21.2 +xref: MetaCyc:1.14.21.2-RXN +is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated + +[Term] +id: GO:0047054 +name: berbamunine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine." [EC:1.14.21.3, MetaCyc:1.1.3.34-RXN] +synonym: "(S)-N-methylcoclaurine oxidase (C-O phenol-coupling) activity" EXACT [EC:1.14.21.3] +synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)" EXACT [EC:1.14.21.3] +xref: EC:1.14.21.3 +xref: MetaCyc:1.1.3.34-RXN +is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated + +[Term] +id: GO:0047055 +name: salutaridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + (R)-reticuline = 2 H2O + NADP+ + salutaridine." [EC:1.14.21.4, MetaCyc:1.1.3.35-RXN] +synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" EXACT [EC:1.14.21.4] +synonym: "(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)" EXACT [EC:1.14.21.4] +xref: EC:1.14.21.4 +xref: MetaCyc:1.1.3.35-RXN +is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated + +[Term] +id: GO:0047056 +name: (S)-canadine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + S-tetrahydrocolumbamine = 2 H2O + NADP+ + S-canadine." [EC:1.14.21.5, MetaCyc:1.1.3.36-RXN] +synonym: "(S)-tetrahydroberberine synthase activity" EXACT [EC:1.14.21.5] +synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.5] +synonym: "(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.5] +xref: EC:1.14.21.5 +xref: MetaCyc:1.1.3.36-RXN +is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated + +[Term] +id: GO:0047057 +name: vitamin-K-epoxide reductase (warfarin-sensitive) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN] +synonym: "2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.1] +synonym: "phylloquinone epoxide reductase activity" EXACT [EC:1.1.4.1] +synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.1.4.1] +xref: EC:1.1.4.1 +xref: MetaCyc:1.1.4.1-RXN +xref: Reactome:82285 +is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor + +[Term] +id: GO:0047058 +name: vitamin-K-epoxide reductase (warfarin-insensitive) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.2, MetaCyc:1.1.4.2-RXN] +synonym: "3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.2] +synonym: "vitamin K 2,3-epoxide reductase activity" EXACT [EC:1.1.4.2] +xref: EC:1.1.4.2 +xref: MetaCyc:1.1.4.2-RXN +is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor + +[Term] +id: GO:0047059 +name: polyvinyl-alcohol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: acceptor + polyvinyl alcohol = donor-H2 + oxidized polyvinyl alcohol." [EC:1.1.99.23, MetaCyc:1.1.99.23-RXN] +subset: gosubset_prok +synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.23] +synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.23] +synonym: "PVA dehydrogenase activity" EXACT [EC:1.1.99.23] +xref: EC:1.1.99.23 +xref: MetaCyc:1.1.99.23-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047060 +name: (R)-pantolactone dehydrogenase (flavin) activity +namespace: molecular_function +def: "Catalysis of the reaction: acceptor + pantoyl lactone = reduced acceptor + 2-dehydropantoyl lactone." [EC:1.1.99.27, MetaCyc:1.1.99.27-RXN] +synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" EXACT [EC:1.1.99.27] +synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" EXACT [EC:1.1.99.27] +synonym: "2-dehydropantolactone reductase (flavin) activity" EXACT [EC:1.1.99.27] +synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" EXACT [EC:1.1.99.27] +xref: EC:1.1.99.27 +xref: MetaCyc:1.1.99.27-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047061 +name: glucose-fructose oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: fructose + beta-D-glucose = D-sorbitol + glucono-delta-lactone." [EC:1.1.99.28, MetaCyc:1.1.99.28-RXN] +subset: gosubset_prok +synonym: "D-glucose:D-fructose oxidoreductase activity" EXACT [EC:1.1.99.28] +xref: EC:1.1.99.28 +xref: MetaCyc:1.1.99.28-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047062 +name: trans-acenaphthene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (+-)-trans-acenaphthene-1,2-diol = NADPH + H+ + acenaphthenequinone." [EC:1.10.1.1, MetaCyc:1.10.1.1-RXN] +synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.10.1.1] +synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" EXACT [EC:1.10.1.1] +xref: EC:1.10.1.1 +xref: MetaCyc:1.10.1.1-RXN +is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor + +[Term] +id: GO:0047063 +name: L-ascorbate-cytochrome-b5 reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [EC:1.10.2.1, MetaCyc:1.10.2.1-RXN] +synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1] +synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1] +xref: EC:1.10.2.1 +xref: MetaCyc:1.10.2.1-RXN +is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor + +[Term] +id: GO:0047064 +name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (+)-bisdechlorogeodin." [EC:1.21.3.4, MetaCyc:1.10.3.7-RXN] +synonym: "sulochrin oxidase activity" EXACT [EC:1.21.3.4] +synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" EXACT [EC:1.21.3.4] +xref: EC:1.21.3.4 +xref: MetaCyc:1.10.3.7-RXN +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0047065 +name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (-)-bisdechlorogeodin." [EC:1.21.3.5, MetaCyc:1.10.3.8-RXN] +synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5] +synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" EXACT [EC:1.21.3.5] +xref: EC:1.21.3.5 +xref: MetaCyc:1.10.3.8-RXN +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0047066 +name: phospholipid-hydroperoxide glutathione peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN] +synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.12] +synonym: "hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] +synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12] +synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" EXACT [EC:1.11.1.12] +synonym: "PHGPX" RELATED [EC:1.11.1.12] +synonym: "phospholipid hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12] +xref: EC:1.11.1.12 +xref: MetaCyc:1.11.1.12-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0047067 +name: hydrogen:quinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: menaquinone + H2 = reduced menaquinone." [EC:1.12.5.1, MetaCyc:1.12.99.3-RXN] +subset: gosubset_prok +synonym: "hydrogen-ubiquinone oxidoreductase activity" EXACT [EC:1.12.5.1] +synonym: "hydrogen:menaquinone oxidoreductase activity" EXACT [EC:1.12.5.1] +synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1] +synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1] +xref: EC:1.12.5.1 +xref: MetaCyc:1.12.5.1-RXN +is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor + +[Term] +id: GO:0047068 +name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity +namespace: molecular_function +alt_id: GO:0016947 +def: "Catalysis of the reaction: H2 + N5,N10-methenyltetrahydromethanopterin = H+ + N5,N10-methylenetetrahydromethanopterin." [EC:1.12.98.2, MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN-RXN] +subset: gosubset_prok +synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] +synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" EXACT [EC:1.12.98.2] +synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] +synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" EXACT [EC:1.12.98.2] +synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2] +synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] +synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] +synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2] +synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2] +synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [] +synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2] +xref: EC:1.12.98.2 +xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN +is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors + +[Term] +id: GO:0047069 +name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 7,8-dihydroxykynurenate = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate." [EC:1.13.11.10, MetaCyc:1.13.11.10-RXN] +synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" EXACT [EC:1.13.11.10] +synonym: "7,8-dihydroxykynurenate oxygenase activity" EXACT [EC:1.13.11.10] +synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10] +xref: EC:1.13.11.10 +xref: MetaCyc:1.13.11.10-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047070 +name: 3-carboxyethylcatechol 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN] +synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" EXACT [EC:1.13.11.16] +synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" EXACT [EC:1.13.11.16] +synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.16] +synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16] +xref: EC:1.13.11.16 +xref: MetaCyc:1.13.11.16-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047071 +name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate." [EC:1.13.11.25, MetaCyc:1.13.11.25-RXN] +synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.25] +synonym: "3-alkylcatechol 2,3-dioxygenase activity" EXACT [EC:1.13.11.25] +synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25] +xref: EC:1.13.11.25 +xref: MetaCyc:1.13.11.25-RXN +xref: UM-BBD_enzymeID:e0715 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047072 +name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2,3-dihydroxybenzoate = 2-carboxy-cis,cis-muconate." [EC:1.13.11.28, MetaCyc:1.13.11.28-RXN] +synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" EXACT [EC:1.13.11.28] +synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.28] +xref: EC:1.13.11.28 +xref: MetaCyc:1.13.11.28-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047073 +name: 2,4'-dihydroxyacetophenone dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2',4'-dihydroxyacetophenone = formate + p-hydroxybenzoate." [EC:1.13.11.41, MetaCyc:1.13.11.41-RXN] +subset: gosubset_prok +synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" EXACT [EC:1.13.11.41] +synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.13.11.41] +xref: EC:1.13.11.41 +xref: MetaCyc:1.13.11.41-RXN +xref: UM-BBD_enzymeID:e0889 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047074 +name: 4-hydroxycatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN] +xref: EC:1.13.11.- +xref: MetaCyc:R308-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047075 +name: 2,5-dihydroxypyridine 5,6-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN] +synonym: "2,5-dihydroxypyridine oxygenase activity" EXACT [EC:1.13.11.9] +synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" EXACT [EC:1.13.11.9] +synonym: "pyridine-2,5-diol dioxygenase activity" EXACT [EC:1.13.11.9] +xref: EC:1.13.11.9 +xref: MetaCyc:1.13.11.9-RXN +xref: UM-BBD_enzymeID:e0911 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047077 +name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + pyrophosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] +synonym: "firefly luciferase activity" EXACT [EC:1.13.12.7] +synonym: "firefly luciferin luciferase activity" EXACT [EC:1.13.12.7] +synonym: "luciferase (firefly luciferin)" EXACT [EC:1.13.12.7] +synonym: "luciferase activity" BROAD [EC:1.13.12.7] +synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" EXACT [EC:1.13.12.7] +synonym: "Photinus pyralis luciferase activity" EXACT [EC:1.13.12.7] +synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" EXACT [EC:1.13.12.7] +synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" EXACT [EC:1.13.12.7] +xref: EC:1.13.12.7 +xref: MetaCyc:1.13.12.7-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0047078 +name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN] +subset: gosubset_prok +synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] +synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [] +synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.47] +synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] +synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] +synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" EXACT [EC:1.13.11.47] +xref: EC:1.13.11.47 +xref: MetaCyc:1.13.11.47-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047079 +name: pyrimidine-deoxynucleoside 1'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + dioxyribonolactone + uracil." [EC:1.14.11.10, MetaCyc:1.14.11.10-RXN] +synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" EXACT [EC:1.14.11.10] +synonym: "deoxyuridine-uridine 1'-dioxygenase activity" EXACT [EC:1.14.11.10] +synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" EXACT [EC:1.14.11.10] +xref: EC:1.14.11.10 +xref: MetaCyc:1.14.11.10-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0047080 +name: pyrimidine-deoxynucleoside 2'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + uridine." [EC:1.14.11.3, MetaCyc:1.14.11.3-RXN] +synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.11.3] +synonym: "deoxyuridine 2'-dioxygenase activity" EXACT [EC:1.14.11.3] +synonym: "deoxyuridine 2'-hydroxylase activity" EXACT [EC:1.14.11.3] +synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" EXACT [EC:1.14.11.3] +synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" EXACT [EC:1.14.11.3] +synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3] +synonym: "thymidine 2'-hydroxylase activity" NARROW [EC:1.14.11.3] +synonym: "thymidine 2-oxoglutarate dioxygenase activity" NARROW [EC:1.14.11.3] +synonym: "thymidine dioxygenase activity" NARROW [EC:1.14.11.3] +xref: EC:1.14.11.3 +xref: MetaCyc:1.14.11.3-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0047081 +name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NAD(P)H + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NAD(P)+ + 2-(acetamidomethylene)succinate." [EC:1.14.12.4, MetaCyc:1.14.12.4-RXN] +synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" EXACT [EC:1.14.12.4] +synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.4] +synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" EXACT [EC:1.14.12.4] +synonym: "methylhydroxypyridine carboxylate dioxygenase activity" EXACT [EC:1.14.12.4] +synonym: "methylhydroxypyridinecarboxylate oxidase activity" EXACT [EC:1.14.12.4] +xref: EC:1.14.12.4 +xref: MetaCyc:1.14.12.4-RXN +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0047082 +name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + (6aR,11aR)-3,9-dihydroxypterocarpan = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.13.28, MetaCyc:1.14.13.28-RXN] +synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" EXACT [EC:1.14.13.28] +synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT [] +synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous)" EXACT [EC:1.14.13.28] +xref: EC:1.14.13.28 +xref: MetaCyc:RXN-4505 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047083 +name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.13.36, MetaCyc:1.14.13.36-RXN] +synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT [] +synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" EXACT [EC:1.14.13.36] +synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.36] +xref: EC:1.14.13.36 +xref: MetaCyc:1.14.13.36-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047084 +name: methyltetrahydroprotoberberine 14-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.13.37, MetaCyc:1.14.13.37-RXN] +synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" EXACT [EC:1.14.13.37] +synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" EXACT [EC:1.14.13.37] +synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" EXACT [EC:1.14.13.37] +synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT [] +xref: EC:1.14.13.37 +xref: MetaCyc:1.14.13.37-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047085 +name: hydroxyphenylacetonitrile 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + 4-hydroxyphenylacetonitrile = H2O + NADP+ + 4-hydroxymandelonitrile." [EC:1.14.13.42, MetaCyc:1.14.13.42-RXN] +synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [EC:1.14.13.42] +synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT [] +synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.42] +xref: EC:1.14.13.42 +xref: MetaCyc:1.14.13.42-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047086 +name: ketosteroid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] +synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" EXACT [EC:1.14.13.54] +synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] +synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54] +synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" EXACT [EC:1.14.13.54] +synonym: "steroid-ketone monooxygenase activity" EXACT [EC:1.14.13.54] +xref: EC:1.14.13.54 +xref: MetaCyc:1.14.13.54-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047087 +name: protopine 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + protopine = H2O + NADP+ + 6-hydroxyprotopine." [EC:1.14.13.55, MetaCyc:1.14.13.55-RXN] +synonym: "protopine 6-hydroxylase activity" EXACT [] +synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.55] +xref: EC:1.14.13.55 +xref: MetaCyc:1.14.13.55-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047088 +name: dihydrosanguinarine 10-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + dihydrosanguinarine = H2O + NADP+ + 10-hydroxydihydrosanguinarine." [EC:1.14.13.56, MetaCyc:1.14.13.56-RXN] +synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT [] +synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" EXACT [EC:1.14.13.56] +xref: EC:1.14.13.56 +xref: MetaCyc:1.14.13.56-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047089 +name: dihydrochelirubine 12-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + dihydrochelirubine = H2O + NADP+ + 10-hydroxydihydrochelirubine." [EC:1.14.13.57, MetaCyc:1.14.13.57-RXN] +synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT [] +synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.57] +xref: EC:1.14.13.57 +xref: MetaCyc:1.14.13.57-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047090 +name: benzoyl-CoA 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + O2 + NADPH = H2O + NADP+ + 3-hydroxybenzoyl-CoA." [EC:1.14.13.58, MetaCyc:1.14.13.58-RXN] +synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT [] +synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.58] +xref: EC:1.14.13.58 +xref: MetaCyc:1.14.13.58-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047091 +name: L-lysine 6-monooxygenase (NADPH) activity +namespace: molecular_function +alt_id: GO:0008739 +def: "Catalysis of the reaction: O2 + NADPH + H+ + L-lysine = H2O + NADP+ + N6-hydroxy-L-lysine." [EC:1.14.13.59, MetaCyc:1.14.13.59-RXN] +comment: Note that EC:1.13.12.10 was merged into this term. +subset: gosubset_prok +synonym: "L-lysine 6-monooxygenase activity" EXACT [] +synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.59] +synonym: "lysine N(6)-hydroxylase activity" EXACT [EC:1.14.13.59] +synonym: "lysine N6-hydroxylase activity" EXACT [] +xref: EC:1.14.13.59 +xref: MetaCyc:1.14.13.59-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047092 +name: 27-hydroxycholesterol 7-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.13.60, MetaCyc:1.14.13.60-RXN] +synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.13.60] +synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT [] +synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.60] +synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.60] +synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.60] +xref: EC:1.14.13.60 +xref: MetaCyc:1.14.13.60-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047093 +name: 4-hydroxyquinoline 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADH + quinolin-4-ol = H2O + NAD+ + quinolin-3,4-diol." [EC:1.14.13.62, MetaCyc:1.14.13.62-RXN] +synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" EXACT [EC:1.14.13.62] +synonym: "quinolin-4(1H)-one 3-monooxygenase activity" EXACT [EC:1.14.13.62] +synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" EXACT [EC:1.14.13.62] +xref: EC:1.14.13.62 +xref: MetaCyc:1.14.13.62-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047094 +name: 3-hydroxyphenylacetate 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN] +synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" EXACT [EC:1.14.13.63] +synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.63] +xref: EC:1.14.13.63 +xref: MetaCyc:1.14.13.63-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047095 +name: 2-hydroxycyclohexanone 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + 2-hydroxycyclohexan-1-one = H2O + NADP+ + 6-hydroxyhexan-6-olide." [EC:1.14.13.66, MetaCyc:1.14.13.66-RXN] +synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.13.66] +xref: EC:1.14.13.66 +xref: MetaCyc:1.14.13.66-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047096 +name: androst-4-ene-3,17-dione monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + donor-H2 + androst-4-ene-3,17-dione = H2O + acceptor + 3-oxo-13,17-secoandrost-4-eno-17,13-alpha-lactone." [EC:1.14.99.12, MetaCyc:1.14.99.12-RXN] +synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT [] +synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" EXACT [EC:1.14.99.12] +synonym: "androst-4-ene-3,17-dione hydroxylase activity" EXACT [EC:1.14.99.12] +synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" EXACT [EC:1.14.99.12] +synonym: "androstene-3,17-dione hydroxylase activity" EXACT [] +synonym: "androstenedione monooxygenase activity" EXACT [EC:1.14.99.12] +xref: EC:1.14.99.12 +xref: MetaCyc:1.14.99.12-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047097 +name: phylloquinone monooxygenase (2,3-epoxidizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + donor-H2 + vitamin K1 = H2O + acceptor + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone." [EC:1.14.99.20, MetaCyc:1.14.99.20-RXN] +synonym: "phylloquinone epoxidase activity" EXACT [EC:1.14.99.20] +synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.20] +synonym: "vitamin K 2,3-epoxidase activity" EXACT [EC:1.14.99.20] +synonym: "vitamin K epoxidase activity" EXACT [EC:1.14.99.20] +synonym: "vitamin K1 epoxidase activity" EXACT [EC:1.14.99.20] +xref: EC:1.14.99.20 +xref: MetaCyc:1.14.99.20-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047098 +name: Latia-luciferin monooxygenase (demethylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN] +synonym: "Latia luciferin monooxygenase (demethylating)" EXACT [EC:1.14.99.21] +synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.99.21] +synonym: "luciferase (Latia luciferin)" EXACT [EC:1.14.99.21] +xref: EC:1.14.99.21 +xref: MetaCyc:1.14.99.21-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0047099 +name: CDP-4-dehydro-6-deoxyglucose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN] +synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.17.1.1] +synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" EXACT [EC:1.17.1.1] +synonym: "CDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.17.1.1] +synonym: "CDP-4-keto-deoxy-glucose reductase activity" EXACT [EC:1.17.1.1] +synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" EXACT [EC:1.17.1.1] +synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" EXACT [EC:1.17.1.1] +synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" EXACT [EC:1.17.1.1] +xref: EC:1.17.1.1 +xref: MetaCyc:1.17.1.1-RXN +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0047100 +name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN] +synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.13] +synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] +synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13] +synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] +synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] +synonym: "NADP-triose phosphate dehydrogenase activity" EXACT [EC:1.2.1.13] +synonym: "triosephosphate dehydrogenase (NADP(+)) activity" EXACT [EC:1.2.1.13] +synonym: "triosephosphate dehydrogenase (NADP)" EXACT [EC:1.2.1.13] +synonym: "triosephosphate dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.13] +xref: EC:1.2.1.13 +xref: MetaCyc:1.2.1.13-RXN +is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity + +[Term] +id: GO:0047101 +name: 2-oxoisovalerate dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN] +synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25] +synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25] +xref: EC:1.2.1.25 +xref: MetaCyc:1.2.1.25-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047102 +name: aminomuconate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN] +synonym: "2-aminomuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] +synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" EXACT [EC:1.2.1.32] +synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] +synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] +synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] +synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] +synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32] +xref: EC:1.2.1.32 +xref: MetaCyc:1.2.1.32-RXN +xref: Reactome:82529 +xref: UM-BBD_enzymeID:e0904 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047103 +name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [EC:1.2.1.40, MetaCyc:1.2.1.40-RXN] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [EC:1.2.1.40] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [EC:1.2.1.40] +synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] +synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [EC:1.2.1.40] +synonym: "cholestanetriol-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40] +synonym: "THAL-NAD oxidoreductase activity" EXACT [EC:1.2.1.40] +synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [EC:1.2.1.40] +xref: EC:1.2.1.40 +xref: MetaCyc:1.2.1.40-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047104 +name: hexadecanal dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + CoA + palmitaldehyde = NADH + palmityl-CoA." [EC:1.2.1.42, MetaCyc:1.2.1.42-RXN] +synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42] +synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.42] +xref: EC:1.2.1.42 +xref: MetaCyc:1.2.1.42-RXN +xref: UM-BBD_enzymeID:e0853 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047105 +name: 4-trimethylammoniobutyraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN] +synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] +synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47] +synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.47] +xref: EC:1.2.1.47 +xref: MetaCyc:1.2.1.47-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047106 +name: 4-hydroxyphenylacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN] +synonym: "4-HPAL dehydrogenase activity" EXACT [EC:1.2.1.53] +synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.53] +xref: EC:1.2.1.53 +xref: MetaCyc:1.2.1.53-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047107 +name: gamma-guanidinobutyraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + 4-guanidinobutanal = NADH + 4-guanidinobutanoate." [EC:1.2.1.54, MetaCyc:1.2.1.54-RXN] +synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.54] +synonym: "4-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] +synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54] +synonym: "GBAL dehydrogenase activity" EXACT [EC:1.2.1.54] +xref: EC:1.2.1.54 +xref: MetaCyc:1.2.1.54-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047108 +name: (R)-3-hydroxyacid-ester dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + ethyl (R)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate." [EC:1.1.1.279, MetaCyc:1.2.1.55-RXN] +comment: Note that this term was EC:1.2.1.55. +synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT [] +synonym: "3-oxo ester (R)-reductase activity" EXACT [EC:1.1.1.279] +synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.279] +xref: EC:1.1.1.279 +xref: MetaCyc:1.2.1.55-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047109 +name: (S)-3-hydroxyacid-ester dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + ethyl (S)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate." [EC:1.1.1.280, MetaCyc:1.2.1.56-RXN] +comment: Note that this term was EC:1.2.1.56. +synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT [] +synonym: "3-oxo ester (S)-reductase activity" EXACT [EC:1.1.1.280] +synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.280] +xref: EC:1.1.1.280 +xref: MetaCyc:1.2.1.56-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047110 +name: phenylglyoxylate dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = NADH + CO2 + benzoyl-S-CoA." [EC:1.2.1.58, MetaCyc:1.2.1.58-RXN] +synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.58] +xref: EC:1.2.1.58 +xref: MetaCyc:1.2.1.58-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047111 +name: formate dehydrogenase (cytochrome-c-553) activity +namespace: molecular_function +def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.2.2.3, MetaCyc:1.2.2.3-RXN] +synonym: "formate dehydrogenase (cytochrome c-553)" EXACT [EC:1.2.2.3] +synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" EXACT [EC:1.2.2.3] +xref: EC:1.2.2.3 +xref: MetaCyc:1.2.2.3-RXN +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0047112 +name: pyruvate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + phosphate + pyruvate = H2O2 + CO2 + acetylphosphate." [EC:1.2.3.3, MetaCyc:1.2.3.3-RXN] +subset: gosubset_prok +synonym: "phosphate-dependent pyruvate oxidase activity" EXACT [EC:1.2.3.3] +synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" EXACT [EC:1.2.3.3] +synonym: "pyruvic oxidase activity" EXACT [EC:1.2.3.3] +xref: EC:1.2.3.3 +xref: MetaCyc:1.2.3.3-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0047113 +name: aldehyde dehydrogenase (pyrroloquinoline-quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acceptor + an aldehyde = donor-H2 + an acid." [EC:1.2.99.3, MetaCyc:1.2.99.3-RXN] +subset: gosubset_prok +synonym: "aldehyde dehydrogenase (acceptor) activity" EXACT [EC:1.2.99.3] +synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3] +xref: EC:1.2.99.3 +xref: MetaCyc:1.2.99.3-RXN +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0047114 +name: kynurenate-7,8-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 7,8-dihydro-7,8-dihydroxykynurenate = NADH + 7,8-dihydroxykynurenate." [EC:1.3.1.18, MetaCyc:1.3.1.18-RXN] +synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" EXACT [EC:1.3.1.18] +synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.18] +synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" EXACT [EC:1.3.1.18] +xref: EC:1.3.1.18 +xref: MetaCyc:1.3.1.18-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047115 +name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN] +subset: gosubset_prok +synonym: "dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.20] +synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.20] +xref: EC:1.3.1.20 +xref: MetaCyc:1.3.1.20-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047116 +name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN] +synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.25] +synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] +synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" EXACT [EC:1.3.1.25] +synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" EXACT [EC:1.3.1.25] +synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.25] +synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.25] +synonym: "DHB dehydrogenase activity" EXACT [EC:1.3.1.25] +synonym: "DHBDH activity" EXACT [EC:1.3.1.25] +synonym: "dihydrodihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25] +xref: EC:1.3.1.25 +xref: MetaCyc:1.3.1.25-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047117 +name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN] +synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.3.1.39] +synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT [] +synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT [] +synonym: "enoyl-ACp reductase activity" EXACT [EC:1.3.1.39] +synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.39] +synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" EXACT [EC:1.3.1.39] +xref: EC:1.3.1.39 +xref: MetaCyc:1.3.1.39-RXN +is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity + +[Term] +id: GO:0047118 +name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 2,6-dioxo-6-phenylhexanoate = NADPH + 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate." [EC:1.3.1.40, MetaCyc:1.3.1.40-RXN] +synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.40] +synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.40] +xref: EC:1.3.1.40 +xref: MetaCyc:1.3.1.40-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047119 +name: 2-methyl-branched-chain-enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 2-methylbutyryl-CoA = NADH + 2-methylcrotonoyl-CoA." [EC:1.3.1.52, MetaCyc:1.3.1.52-RXN] +synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" EXACT [EC:1.3.1.52] +xref: EC:1.3.1.52 +xref: MetaCyc:1.3.1.52-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047120 +name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate = NADH + CO2 + protocatechuate." [EC:1.3.1.53, MetaCyc:1.3.1.53-RXN] +synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] +synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.53] +synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53] +xref: EC:1.3.1.53 +xref: MetaCyc:1.3.1.53-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047121 +name: isoquinoline 1-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acceptor + isoquinoline = donor-H2 + isoquinolin-12H-one." [EC:1.3.99.16, MetaCyc:1.3.99.16-RXN] +subset: gosubset_prok +synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.16] +xref: EC:1.3.99.16 +xref: MetaCyc:1.3.99.16-RXN +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047122 +name: quinaldate 4-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acceptor + quinaldate = donor-H2 + kynurenate." [EC:1.3.99.18, MetaCyc:1.3.99.18-RXN] +synonym: "quinaldic acid 4-oxidoreductase activity" EXACT [EC:1.3.99.18] +synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.18] +xref: EC:1.3.99.18 +xref: MetaCyc:1.3.99.18-RXN +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047123 +name: quinoline-4-carboxylate 2-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acceptor + quinoline-4-carboxylate = quinolin-2-ol + donor-H2." [EC:1.3.99.19, MetaCyc:1.3.99.19-RXN] +synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.19] +synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" EXACT [EC:1.3.99.19] +xref: EC:1.3.99.19 +xref: MetaCyc:1.3.99.19-RXN +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047124 +name: L-erythro-3,5-diaminohexanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O + (3S,5S)-3,5-diaminohexanoate = NADH + NH3 + (S)-5-amino-3-oxohexanoate." [EC:1.4.1.11, MetaCyc:1.4.1.11-RXN] +synonym: "L-3,5-diaminohexanoate dehydrogenase activity" EXACT [EC:1.4.1.11] +synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.11] +xref: EC:1.4.1.11 +xref: MetaCyc:1.4.1.11-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047125 +name: delta1-piperideine-2-carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta(1)-piperideine-2-carboxylate." [EC:1.5.1.21, MetaCyc:1.5.1.21-RXN] +synonym: "1,2-didehydropipecolate reductase activity" EXACT [EC:1.5.1.21] +synonym: "1,2-didehydropipecolic reductase activity" EXACT [EC:1.5.1.21] +synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT [] +synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT [] +synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.5.1.21] +synonym: "P2C reductase activity" EXACT [EC:1.5.1.21] +xref: EC:1.5.1.21 +xref: MetaCyc:1.5.1.21-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047126 +name: N5-(carboxyethyl)ornithine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NADP+ + N5-(L-1-carboxyethyl)-L-ornithine = NADPH + pyruvate + L-ornithine." [EC:1.5.1.24, MetaCyc:1.5.1.24-RXN] +subset: gosubset_prok +synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] +synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24] +xref: EC:1.5.1.24 +xref: MetaCyc:1.5.1.24-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047127 +name: thiomorpholine-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN] +synonym: "ketimine reductase activity" EXACT [EC:1.5.1.25] +synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25] +synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" EXACT [EC:1.5.1.25] +xref: EC:1.5.1.25 +xref: MetaCyc:1.5.1.25-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047128 +name: 1,2-dehydroreticulinium reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + 1,2-dehydroreticulinium = NADP+ + R-reticuline." [EC:1.5.1.27, MetaCyc:1.5.1.27-RXN] +synonym: "(R)-reticuline:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.27] +synonym: "1,2-dehydroreticulinium ion reductase activity" EXACT [EC:1.5.1.27] +xref: EC:1.5.1.27 +xref: MetaCyc:1.5.1.27-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047129 +name: opine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate = NADH + pyruvate + L-2-aminopentanoic acid." [EC:1.5.1.28, MetaCyc:1.5.1.28-RXN] +subset: gosubset_prok +synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] +synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" EXACT [EC:1.5.1.28] +xref: EC:1.5.1.28 +xref: MetaCyc:1.5.1.28-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047130 +name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity +namespace: molecular_function +alt_id: GO:0010010 +def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+." [EC:1.5.1.8, MetaCyc:1.5.1.8-RXN] +subset: gosubset_prok +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] +synonym: "L-lysine-alpha-ketoglutarate reductase activity" EXACT [EC:1.5.1.8] +synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" EXACT [EC:1.5.1.8] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8] +synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" EXACT [EC:1.5.1.8] +xref: EC:1.5.1.8 +xref: MetaCyc:1.5.1.8-RXN +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0047131 +name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+." [EC:1.5.1.9, MetaCyc:1.5.1.9-RXN] +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] +synonym: "aminoadipic semialdehyde synthase activity" EXACT [EC:1.5.1.9] +synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" EXACT [EC:1.5.1.9] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9] +synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" EXACT [EC:1.5.1.9] +synonym: "saccharopin dehydrogenase activity" EXACT [EC:1.5.1.9] +xref: EC:1.5.1.9 +xref: MetaCyc:1.5.1.9-RXN +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0047132 +name: dihydrobenzophenanthridine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN] +synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12] +xref: EC:1.5.3.12 +xref: MetaCyc:1.5.3.12-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0047133 +name: dimethylamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN] +subset: gosubset_prok +synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" EXACT [EC:1.5.8.1] +synonym: "DMADh activity" EXACT [EC:1.5.8.1] +xref: EC:1.5.8.1 +xref: MetaCyc:1.5.8.1-RXN +xref: UM-BBD_enzymeID:e0855 +is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor + +[Term] +id: GO:0047134 +name: protein-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN] +subset: gosubset_prok +synonym: "disulfide reductase activity" EXACT [EC:1.8.1.8] +synonym: "insulin-glutathione transhydrogenase activity" EXACT [EC:1.8.1.8] +synonym: "NAD(P)H2:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] +synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8] +synonym: "protein disulfide reductase activity" EXACT [EC:1.8.1.8] +synonym: "protein disulphide reductase activity" EXACT [EC:1.8.1.8] +synonym: "protein-disulfide reductase (NAD(P)H) activity" EXACT [] +synonym: "protein-disulphide reductase activity" EXACT [] +synonym: "protein-dithiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.8] +xref: EC:1.8.1.8 +xref: MetaCyc:1.6.4.4-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047135 +name: bis-gamma-glutamylcystine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+." [EC:1.8.1.13, MetaCyc:1.6.4.9-RXN] +synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT [] +synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" EXACT [EC:1.8.1.13] +synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" EXACT [EC:1.8.1.13] +synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.13] +synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] +synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13] +xref: EC:1.8.1.13 +xref: MetaCyc:1.6.4.9-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047136 +name: 4-(dimethylamino)phenylazoxybenzene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-dimethylaminophenylazobenzene + NADP+ = 4-(dimethylamino)phenylazoxybenzene + NADPH + H+." [EC:1.7.1.11, MetaCyc:1.6.6.12-RXN] +synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.11] +synonym: "dimethylaminoazobenzene N-oxide reductase activity" EXACT [EC:1.7.1.11] +synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" EXACT [EC:1.7.1.11] +synonym: "NADPH-dependent DMAB N-oxide reductase activity" EXACT [EC:1.7.1.11] +synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] +synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11] +xref: EC:1.7.1.11 +xref: MetaCyc:1.6.6.12-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0047137 +name: N-hydroxy-2-acetamidofluorene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN] +synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.12] +synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" EXACT [EC:1.7.1.12] +synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] +synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12] +xref: EC:1.7.1.12 +xref: MetaCyc:1.7.1.12-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0047138 +name: aquacobalamin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN] +subset: gosubset_prok +synonym: "aquocobalamin reductase activity" EXACT [EC:1.16.1.3] +synonym: "B(12a) reductase activity" EXACT [EC:1.16.1.3] +synonym: "B12a reductase activity" EXACT [EC:1.16.1.3] +synonym: "cob(II)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.3] +synonym: "NADH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.3] +synonym: "NADH2:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] +synonym: "NADH:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3] +synonym: "vitamin B(12a) reductase activity" EXACT [EC:1.16.1.3] +synonym: "vitamin B12a reductase activity" EXACT [EC:1.16.1.3] +xref: EC:1.16.1.3 +xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0047139 +name: glutathione-homocystine transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN] +synonym: "glutathione:homocystine oxidoreductase activity" EXACT [EC:1.8.4.1] +xref: EC:1.8.4.1 +xref: MetaCyc:1.8.4.1-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047140 +name: glutathione-CoA-glutathione transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN] +synonym: "CoA:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] +synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3] +synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.4.3] +synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] +synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" EXACT [EC:1.8.4.3] +synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3] +xref: EC:1.8.4.3 +xref: MetaCyc:1.8.4.3-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047141 +name: glutathione-cystine transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN] +synonym: "glutathione:cystine oxidoreductase" EXACT [EC:1.8.4.4] +synonym: "GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] +synonym: "NADPH-dependent GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4] +xref: EC:1.8.4.4 +xref: MetaCyc:1.8.4.4-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047142 +name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN] +synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] +synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT [] +synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT [] +synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] +synonym: "thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7] +synonym: "thiol:disulphide oxidoreductase activity" EXACT [EC:1.8.4.7] +synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.7] +synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7] +xref: EC:1.8.4.7 +xref: MetaCyc:1.8.4.7-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047143 +name: chlorate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorate + donor-H2 = chlorite + H2O + acceptor." [EC:1.97.1.1, MetaCyc:1.97.1.1-RXN] +subset: gosubset_prok +synonym: "chlorate reductase C" RELATED [EC:1.97.1.1] +synonym: "chlorite:acceptor oxidoreductase activity" EXACT [EC:1.97.1.1] +xref: EC:1.97.1.1 +xref: MetaCyc:1.97.1.1-RXN +xref: UM-BBD_enzymeID:e0609 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0047144 +name: 2-acylglycerol-3-phosphate O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, MetaCyc:2-ACYL2.3.1.15-RXN] +synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52] +synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52] +xref: EC:2.3.1.52 +xref: MetaCyc:2-ACYL2.3.1.15-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047145 +name: demethylsterigmatocystin 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN] +synonym: "demethylsterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.109] +synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109] +synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" EXACT [EC:2.1.1.109] +xref: EC:2.1.1.109 +xref: MetaCyc:2.1.1.109-RXN +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0047146 +name: sterigmatocystin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN] +synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110] +synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" EXACT [EC:2.1.1.110] +synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] +synonym: "sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110] +synonym: "sterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.110] +xref: EC:2.1.1.110 +xref: MetaCyc:2.1.1.110-RXN +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0047147 +name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: THF + trimethyl sulfonium = 5-methyl-THF + dimethyl sulfide." [EC:2.1.1.19, MetaCyc:2.1.1.19-RXN] +synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.19] +synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" EXACT [EC:2.1.1.19] +synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT [] +xref: EC:2.1.1.19 +xref: MetaCyc:2.1.1.19-RXN +is_a: GO:0008170 ! N-methyltransferase activity + +[Term] +id: GO:0047148 +name: methylamine-glutamate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + methylamine = N-methyl-L-glutamate + NH3." [EC:2.1.1.21, MetaCyc:2.1.1.21-RXN] +synonym: "methylamine-glutamate methyltransferase activity" EXACT [EC:2.1.1.21] +synonym: "methylamine:L-glutamate N-methyltransferase activity" EXACT [EC:2.1.1.21] +synonym: "N-methylglutamate synthase activity" EXACT [EC:2.1.1.21] +xref: EC:2.1.1.21 +xref: MetaCyc:2.1.1.21-RXN +is_a: GO:0008170 ! N-methyltransferase activity + +[Term] +id: GO:0047149 +name: thetin-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homocysteine + dimethylsulfonioacetate = L-methionine + S-methylthioglycolate." [EC:2.1.1.3, MetaCyc:2.1.1.3-RXN] +synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.3] +synonym: "dimethylthetin-homocysteine methyltransferase activity" EXACT [EC:2.1.1.3] +synonym: "thetin-homocysteine methylpherase activity" EXACT [EC:2.1.1.3] +xref: EC:2.1.1.3 +xref: MetaCyc:2.1.1.3-RXN +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0047150 +name: betaine-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homocysteine + betaine = L-methionine + dimethylglycine." [EC:2.1.1.5, MetaCyc:2.1.1.5-RXN] +synonym: "betaine-homocysteine methyltransferase activity" EXACT [EC:2.1.1.5] +synonym: "betaine-homocysteine transmethylase activity" EXACT [EC:2.1.1.5] +synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.5] +xref: EC:2.1.1.5 +xref: MetaCyc:2.1.1.5-RXN +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0047151 +name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: FADH + H+ + tRNA U(psi)C = FAD+ + tRNA T(psi)C + THF." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN] +synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.74] +synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" EXACT [EC:2.1.1.74] +synonym: "folate-dependent ribothymidyl synthase activity" EXACT [EC:2.1.1.74] +synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" EXACT [EC:2.1.1.74] +synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT [] +xref: EC:2.1.1.74 +xref: MetaCyc:2.1.1.74-RXN +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0047152 +name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [EC:2.1.1.90, MetaCyc:2.1.1.90-RXN] +comment: This function is the first step in the pathway of methanogenesis from methanol. +subset: gosubset_prok +synonym: "methanol cobalamin methyltransferase activity" EXACT [EC:2.1.1.90] +synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" EXACT [EC:2.1.1.90] +synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" EXACT [EC:2.1.1.90] +synonym: "methanol:corrinoid methyltransferase activity" EXACT [] +synonym: "methyltransferase 1" BROAD [] +synonym: "MT 1" RELATED [EC:2.1.1.90] +synonym: "MT1" RELATED [] +synonym: "MtaB" RELATED [] +xref: EC:2.1.1.90 +xref: MetaCyc:2.1.1.90-RXN +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0047153 +name: deoxycytidylate 5-hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, MetaCyc:2.1.2.8-RXN] +synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" EXACT [EC:2.1.2.8] +synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" EXACT [EC:2.1.2.8] +synonym: "dCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] +synonym: "deoxyCMP hydroxymethylase activity" EXACT [EC:2.1.2.8] +synonym: "deoxycytidylate hydroxymethylase activity" EXACT [EC:2.1.2.8] +synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT [] +synonym: "deoxycytidylic hydroxymethylase activity" EXACT [EC:2.1.2.8] +xref: EC:2.1.2.8 +xref: MetaCyc:2.1.2.8-RXN +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0047154 +name: methylmalonyl-CoA carboxytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN] +subset: gosubset_prok +synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1] +synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] +synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1] +synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" EXACT [EC:2.1.3.1] +synonym: "methylmalonyl coenzyme A carboxyltransferase activity" EXACT [EC:2.1.3.1] +synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT [] +synonym: "methylmalonyl-CoA transcarboxylase activity" EXACT [EC:2.1.3.1] +synonym: "oxalacetic transcarboxylase activity" EXACT [EC:2.1.3.1] +synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1] +xref: EC:2.1.3.1 +xref: MetaCyc:2.1.3.1-RXN +xref: UM-BBD_enzymeID:e0576 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0047155 +name: 3-hydroxymethylcephem carbamoyltransferase activity +namespace: molecular_function +alt_id: GO:0045447 +def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN] +synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT [] +synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" EXACT [EC:2.1.3.7] +xref: EC:2.1.3.7 +xref: MetaCyc:2.1.3.7-RXN +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0047156 +name: acetoin-ribose-5-phosphate transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribose-5-phosphate + 3-hydroxybutan-2-one = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [EC:2.2.1.4, MetaCyc:2.2.1.4-RXN] +synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" EXACT [EC:2.2.1.4] +synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" EXACT [EC:2.2.1.4] +synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] +synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4] +xref: EC:2.2.1.4 +xref: MetaCyc:2.2.1.4-RXN +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0047157 +name: myelin-proteolipid O-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [EC:2.3.1.100, MetaCyc:2.3.1.100-RXN] +synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] +synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100] +synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100] +synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100] +xref: EC:2.3.1.100 +xref: MetaCyc:2.3.1.100-RXN +is_a: GO:0016416 ! O-palmitoyltransferase activity + +[Term] +id: GO:0047158 +name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucoside = 1,2-bis-O-sinapoyl beta-D-glucoside + beta-D-glucose." [EC:2.3.1.103, MetaCyc:2.3.1.103-RXN] +synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] +synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" EXACT [EC:2.3.1.103] +synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103] +xref: EC:2.3.1.103 +xref: MetaCyc:2.3.1.103-RXN +is_a: GO:0016753 ! O-sinapoyltransferase activity + +[Term] +id: GO:0047159 +name: 1-alkenylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN] +synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.104] +xref: EC:2.3.1.104 +xref: MetaCyc:2.3.1.104-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047160 +name: alkylglycerophosphate 2-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, MetaCyc:2.3.1.105-RXN] +synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" EXACT [EC:2.3.1.105] +synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.105] +xref: EC:2.3.1.105 +xref: MetaCyc:2.3.1.105-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047161 +name: tartronate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxymalonate + sinapoyl-CoA = sinapoyltartronate + CoA." [EC:2.3.1.106, MetaCyc:2.3.1.106-RXN] +synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.106] +synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.106] +synonym: "tartronate sinapoyltransferase activity" EXACT [EC:2.3.1.106] +xref: EC:2.3.1.106 +xref: MetaCyc:2.3.1.106-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047162 +name: 17-O-deacetylvindoline O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17-O-deacetylvindoline + acetyl-CoA = vindoline + CoA." [EC:2.3.1.107, MetaCyc:2.3.1.107-RXN] +synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "DAT activity" EXACT [EC:2.3.1.107] +synonym: "deacetylvindoline acetyltransferase activity" EXACT [EC:2.3.1.107] +synonym: "deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107] +xref: EC:2.3.1.107 +xref: MetaCyc:2.3.1.107-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047163 +name: 3,4-dichloroaniline N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonate + CoA." [EC:2.3.1.114, MetaCyc:2.3.1.114-RXN] +synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" EXACT [EC:2.3.1.114] +xref: EC:2.3.1.114 +xref: MetaCyc:2.3.1.114-RXN +is_a: GO:0050735 ! N-malonyltransferase activity + +[Term] +id: GO:0047164 +name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN] +synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] +synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] +synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115] +synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.115] +synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115] +synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" EXACT [EC:2.3.1.115] +synonym: "MAT-7" RELATED [EC:2.3.1.115] +xref: EC:2.3.1.115 +xref: MetaCyc:2.3.1.115-RXN +is_a: GO:0050736 ! O-malonyltransferase activity + +[Term] +id: GO:0047165 +name: flavonol-3-O-beta-glucoside O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN] +synonym: "flavonol 3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] +synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.116] +synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116] +synonym: "MAT-3" RELATED [EC:2.3.1.116] +xref: EC:2.3.1.116 +xref: MetaCyc:2.3.1.116-RXN +is_a: GO:0050736 ! O-malonyltransferase activity + +[Term] +id: GO:0047166 +name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN] +synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.121] +xref: EC:2.3.1.121 +xref: MetaCyc:2.3.1.121-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047167 +name: 1-alkyl-2-acetylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN] +synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1.125] +synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125] +xref: EC:2.3.1.125 +xref: MetaCyc:2.3.1.125-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047168 +name: isocitrate O-dihydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: threo-d(s)-iso-citrate + caffeoyl-CoA = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, MetaCyc:2.3.1.126-RXN] +synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.126] +xref: EC:2.3.1.126 +xref: MetaCyc:2.3.1.126-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047169 +name: galactarate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-CoA + D-galactarate = O-feruloylgalactarate + CoA." [EC:2.3.1.130, MetaCyc:2.3.1.130-RXN] +synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.130] +synonym: "galacturate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.130] +xref: EC:2.3.1.130 +xref: MetaCyc:2.3.1.130-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047170 +name: glucarate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = O-sinapoylglucarate + CoA." [EC:2.3.1.131, MetaCyc:2.3.1.131-RXN] +synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.131] +xref: EC:2.3.1.131 +xref: MetaCyc:2.3.1.131-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047171 +name: glucarolactone O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN] +synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.132] +xref: EC:2.3.1.132 +xref: MetaCyc:2.3.1.132-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047172 +name: shikimate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN] +synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.133] +synonym: "shikimate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.133] +xref: EC:2.3.1.133 +xref: MetaCyc:2.3.1.133-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047173 +name: phosphatidylcholine-retinol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN] +synonym: "lecithin--retinol acyltransferase activity" EXACT [EC:2.3.1.135] +synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" EXACT [EC:2.3.1.135] +synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" EXACT [EC:2.3.1.135] +xref: EC:2.3.1.135 +xref: MetaCyc:2.3.1.135-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047174 +name: putrescine N-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: putrescine + caffeoyl-CoA = N-caffeoylputrescine + CoA." [EC:2.3.1.138, MetaCyc:2.3.1.138-RXN] +synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" EXACT [EC:2.3.1.138] +synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.138] +synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] +synonym: "PHT" RELATED [EC:2.3.1.138] +synonym: "putrescine hydroxycinnamoyl transferase activity" EXACT [EC:2.3.1.138] +synonym: "putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138] +xref: EC:2.3.1.138 +xref: MetaCyc:2.3.1.138-RXN +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0050734 ! hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047175 +name: galactosylacylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN] +synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" EXACT [EC:2.3.1.141] +synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.141] +synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141] +xref: EC:2.3.1.141 +xref: MetaCyc:2.3.1.141-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047176 +name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + beta-D-glucose." [EC:2.3.1.143, MetaCyc:2.3.1.143-RXN] +synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] +synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" EXACT [EC:2.3.1.143] +synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] +synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143] +xref: EC:2.3.1.143 +xref: MetaCyc:2.3.1.143-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047177 +name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN] +synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] +synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147] +xref: EC:2.3.1.147 +xref: MetaCyc:2.3.1.147-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047178 +name: glycerophospholipid acyltransferase (CoA-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN] +synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148] +xref: EC:2.3.1.148 +xref: MetaCyc:2.3.1.148-RXN +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0047179 +name: platelet-activating factor acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN] +synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" EXACT [EC:2.3.1.149] +synonym: "PAF acetyltransferase activity" EXACT [] +xref: EC:2.3.1.149 +xref: MetaCyc:2.3.1.149-RXN +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0047180 +name: salutaridinol 7-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: salutaridinol + acetyl-CoA = 7-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, MetaCyc:2.3.1.150-RXN] +synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" EXACT [EC:2.3.1.150] +xref: EC:2.3.1.150 +xref: MetaCyc:2.3.1.150-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047181 +name: benzophenone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN] +synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.151] +xref: EC:2.3.1.151 +xref: MetaCyc:2.3.1.151-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047182 +name: alcohol O-cinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN] +synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" EXACT [EC:2.3.1.152] +xref: EC:2.3.1.152 +xref: MetaCyc:2.3.1.152-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047183 +name: anthocyanin 5-aromatic acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN] +synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153] +xref: EC:2.3.1.153 +xref: MetaCyc:2.3.1.153-RXN +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0047184 +name: 1-acylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +alt_id: GO:0000507 +def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN] +synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.23] +synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] +synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" EXACT [EC:2.3.1.23] +synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.23] +synonym: "lysolecithin acyltransferase activity" EXACT [EC:2.3.1.23] +synonym: "lysophosphatide acyltransferase activity" EXACT [EC:2.3.1.23] +synonym: "lysophosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23] +xref: EC:2.3.1.23 +xref: MetaCyc:2.3.1.23-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047185 +name: N-acetylneuraminate 4-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, MetaCyc:2.3.1.44-RXN] +synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" EXACT [EC:2.3.1.44] +synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44] +xref: EC:2.3.1.44 +xref: MetaCyc:2.3.1.44-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047186 +name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN] +synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "glycoprotein 7(9)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2.3.1.45] +synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45] +xref: EC:2.3.1.45 +xref: MetaCyc:2.3.1.45-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047187 +name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN] +synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" EXACT [EC:2.3.1.49] +synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] +synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49] +synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49] +xref: EC:2.3.1.49 +xref: MetaCyc:2.3.1.49-RXN +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0047188 +name: aromatic-hydroxylamine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN] +synonym: "aromatic hydroxylamine acetyltransferase activity" EXACT [EC:2.3.1.56] +synonym: "arylhydroxamate acyltransferase activity" EXACT [EC:2.3.1.56] +synonym: "arylhydroxamic acid N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] +synonym: "arylhydroxamic acyltransferase activity" EXACT [EC:2.3.1.56] +synonym: "N,O-acetyltransferase activity" EXACT [EC:2.3.1.56] +synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" EXACT [EC:2.3.1.56] +synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" EXACT [EC:2.3.1.56] +xref: EC:2.3.1.56 +xref: MetaCyc:2.3.1.56-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047189 +name: 2,3-diaminopropionate N-oxalyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,3-diaminopropanoate + oxalyl-CoA = N3-oxalyl-L-23-diaminopropanoate + CoA." [EC:2.3.1.58, MetaCyc:2.3.1.58-RXN] +synonym: "ODAP synthase activity" EXACT [EC:2.3.1.58] +synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" EXACT [EC:2.3.1.58] +synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" EXACT [EC:2.3.1.58] +synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" EXACT [EC:2.3.1.58] +synonym: "oxalyldiaminopropionate synthase activity" EXACT [EC:2.3.1.58] +synonym: "oxalyldiaminopropionic synthase activity" EXACT [EC:2.3.1.58] +xref: EC:2.3.1.58 +xref: MetaCyc:2.3.1.58-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047190 +name: 2-acylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.62, MetaCyc:2.3.1.62-RXN] +synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.62] +synonym: "2-acylglycerophosphocholine acyltransferase activity" EXACT [EC:2.3.1.62] +synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.62] +xref: EC:2.3.1.62 +xref: MetaCyc:2.3.1.62-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047191 +name: 1-alkylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] +synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63] +xref: EC:2.3.1.63 +xref: MetaCyc:2.3.1.63-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047192 +name: 1-alkylglycerophosphocholine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN] +synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lysoPAF:acetyl CoA acetyltransferase activity" EXACT [EC:2.3.1.67] +synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67] +synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67] +xref: EC:2.3.1.67 +xref: MetaCyc:2.3.1.67-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047193 +name: CDP-acylglycerol O-arachidonoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN] +synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [EC:2.3.1.70] +synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] +synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT [] +synonym: "CDPacylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70] +xref: EC:2.3.1.70 +xref: MetaCyc:2.3.1.70-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047194 +name: indoleacetylglucose-inositol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + indole-3-acetyl-beta-1-D-glucose = indole-3-acetyl-myo-inositol + beta-D-glucose." [EC:2.3.1.72, MetaCyc:2.3.1.72-RXN] +synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" EXACT [EC:2.3.1.72] +synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" EXACT [EC:2.3.1.72] +synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" EXACT [EC:2.3.1.72] +xref: EC:2.3.1.72 +xref: MetaCyc:2.3.1.72-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047195 +name: diacylglycerol-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN] +synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3.1.73] +synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73] +xref: EC:2.3.1.73 +xref: MetaCyc:2.3.1.73-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047196 +name: long-chain-alcohol O-fatty-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN] +synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" EXACT [EC:2.3.1.75] +synonym: "wax synthase activity" RELATED [EC:2.3.1.75] +synonym: "wax-ester synthase activity" EXACT [EC:2.3.1.75] +xref: EC:2.3.1.75 +xref: MetaCyc:2.3.1.75-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047197 +name: triacylglycerol-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN] +synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT [EC:2.3.1.77] +synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77] +xref: EC:2.3.1.77 +xref: MetaCyc:2.3.1.77-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047198 +name: cysteine-S-conjugate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an S-substituted L-cysteine + acetyl-CoA = an S-substituted N-acetyl-L-cysteine + CoA." [EC:2.3.1.80, MetaCyc:2.3.1.80-RXN] +synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" EXACT [EC:2.3.1.80] +xref: EC:2.3.1.80 +xref: MetaCyc:2.3.1.80-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047199 +name: phosphatidylcholine-dolichol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichol + phosphatidylcholine = acyldolichol + 1-acyl-sn-glycero-3-phosphocholine." [EC:2.3.1.83, MetaCyc:2.3.1.83-RXN] +synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" EXACT [EC:2.3.1.83] +xref: EC:2.3.1.83 +xref: MetaCyc:2.3.1.83-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047200 +name: tetrahydrodipicolinate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA = L-2-acetamido-6-oxoheptanedioate + CoA." [EC:2.3.1.89, MetaCyc:2.3.1.89-RXN] +subset: gosubset_prok +synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] +synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" EXACT [EC:2.3.1.89] +synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" EXACT [EC:2.3.1.89] +synonym: "tetrahydrodipicolinate acetylase activity" EXACT [EC:2.3.1.89] +synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.89] +xref: EC:2.3.1.89 +xref: MetaCyc:2.3.1.89-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047201 +name: beta-glucogallin O-galloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1-O,6-O-digalloyl-beta-D-glucose + beta-D-glucose." [EC:2.3.1.90, MetaCyc:2.3.1.90-RXN] +synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" EXACT [EC:2.3.1.90] +xref: EC:2.3.1.90 +xref: MetaCyc:2.3.1.90-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047202 +name: sinapoylglucose-choline O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline + 1-O-sinapoyl-beta-D-glucose = O-sinapoylcholine + beta-D-glucose." [EC:2.3.1.91, MetaCyc:2.3.1.91-RXN] +synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" EXACT [EC:2.3.1.91] +synonym: "sinapine synthase activity" EXACT [EC:2.3.1.91] +xref: EC:2.3.1.91 +xref: MetaCyc:2.3.1.91-RXN +is_a: GO:0016753 ! O-sinapoyltransferase activity + +[Term] +id: GO:0047203 +name: 13-hydroxylupinine O-tigloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 13-hydroxylupinine + (E)-2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyl)oxylupinine + CoA." [EC:2.3.1.93, MetaCyc:2.3.1.93-RXN] +synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" EXACT [EC:2.3.1.93] +synonym: "13-hydroxylupanine acyltransferase activity" EXACT [EC:2.3.1.93] +synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" EXACT [EC:2.3.1.93] +xref: EC:2.3.1.93 +xref: MetaCyc:2.3.1.93-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047204 +name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucarate + chlorogenate = 2-O-caffeoylglucarate + quinate." [EC:2.3.1.98, MetaCyc:2.3.1.98-RXN] +synonym: "chlorogenate:glucarate caffeoyltransferase activity" EXACT [EC:2.3.1.98] +synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.98] +synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" EXACT [EC:2.3.1.98] +xref: EC:2.3.1.98 +xref: MetaCyc:2.3.1.98-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047205 +name: quinate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN] +synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.99] +synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" EXACT [EC:2.3.1.99] +xref: EC:2.3.1.99 +xref: MetaCyc:2.3.1.99-RXN +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047206 +name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN] +synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10] +synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" EXACT [EC:2.3.2.10] +synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] +synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] +synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] +synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10] +synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10] +xref: EC:2.3.2.10 +xref: MetaCyc:2.3.2.10-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0047207 +name: 1,2-beta-fructan 1F-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1,2-beta-D-fructosyl)(n) + (1,2-beta-D-fructosyl)(m) = (1,2-beta-D-fructosyl)(n+1) + (1,2-beta-D-fructosyl)(m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN] +synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" EXACT [EC:2.4.1.100] +synonym: "FFT activity" EXACT [EC:2.4.1.100] +synonym: "fructan:fructan fructosyl transferase activity" EXACT [EC:2.4.1.100] +xref: EC:2.4.1.100 +xref: MetaCyc:2.4.1.100-RXN +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0047208 +name: o-dihydroxycoumarin 7-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + UDP." [EC:2.4.1.104, MetaCyc:2.4.1.104-RXN] +synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] +synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" EXACT [EC:2.4.1.104] +synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104] +synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.104] +xref: EC:2.4.1.104 +xref: MetaCyc:2.4.1.104-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047209 +name: coniferyl-alcohol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN] +synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] +synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] +synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111] +synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111] +xref: EC:2.4.1.111 +xref: MetaCyc:2.4.1.111-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047210 +name: alpha-1,4-glucan-protein synthase (UDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: protein + UDP-D-glucose = alpha-D-glucosyl-protein + UDP." [EC:2.4.1.112, MetaCyc:2.4.1.112-RXN] +synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] +xref: EC:2.4.1.112 +xref: MetaCyc:2.4.1.112-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047211 +name: alpha-1,4-glucan-protein synthase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN] +synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT [] +synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" EXACT [EC:2.4.1.113] +synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] +synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113] +synonym: "ADPglucose:protein glucosyltransferase activity" EXACT [EC:2.4.1.113] +xref: EC:2.4.1.113 +xref: MetaCyc:2.4.1.113-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047212 +name: 2-coumarate O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + UDP." [EC:2.4.1.114, MetaCyc:2.4.1.114-RXN] +synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] +synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" EXACT [EC:2.4.1.114] +synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114] +synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" EXACT [EC:2.4.1.114] +xref: EC:2.4.1.114 +xref: MetaCyc:2.4.1.114-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047213 +name: anthocyanidin 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN] +synonym: "3-GT activity" EXACT [EC:2.4.1.115] +synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] +synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.115] +synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] +synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] +synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115] +xref: EC:2.4.1.115 +xref: MetaCyc:2.4.1.115-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047214 +name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN] +synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] +synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] +synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.116] +synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116] +xref: EC:2.4.1.116 +xref: MetaCyc:2.4.1.116-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047215 +name: indole-3-acetate beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: auxin + UDP-D-glucose = indole-3-acetyl-beta-1-D-glucose + UDP." [EC:2.4.1.121, MetaCyc:2.4.1.121-RXN] +synonym: "IAA-Glu synthetase activity" EXACT [EC:2.4.1.121] +synonym: "IAA-glucose synthase activity" EXACT [EC:2.4.1.121] +synonym: "IAGlu synthase activity" EXACT [EC:2.4.1.121] +synonym: "indol-3-ylacetylglucose synthase activity" EXACT [EC:2.4.1.121] +synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] +synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" EXACT [EC:2.4.1.121] +synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] +synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" EXACT [EC:2.4.1.121] +synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121] +synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" EXACT [EC:2.4.1.121] +xref: EC:2.4.1.121 +xref: MetaCyc:2.4.1.121-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047216 +name: inositol 3-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN] +synonym: "galactinol synthase activity" EXACT [EC:2.4.1.123] +synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT [] +synonym: "UDP-D-galactose:inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] +synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] +synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] +synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123] +synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" EXACT [EC:2.4.1.123] +xref: EC:2.4.1.123 +xref: MetaCyc:2.4.1.123-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047217 +name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN] +synonym: "GTF-S" RELATED [EC:2.4.1.125] +synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125] +synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.125] +synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.125] +synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125] +xref: EC:2.4.1.125 +xref: MetaCyc:2.4.1.125-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0047218 +name: hydroxycinnamate 4-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN] +synonym: "hydroxycinnamoyl glucosyltransferase activity" EXACT [EC:2.4.1.126] +synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] +synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] +synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126] +synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126] +xref: EC:2.4.1.126 +xref: MetaCyc:2.4.1.126-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047219 +name: monoterpenol beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl O-beta-D-glucoside + UDP." [EC:2.4.1.127, MetaCyc:2.4.1.127-RXN] +synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] +synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127] +synonym: "UDPglucose:monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] +synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127] +xref: EC:2.4.1.127 +xref: MetaCyc:2.4.1.127-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047220 +name: galactosylxylosylprotein 3-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN] +synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134] +synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] +synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134] +synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" EXACT [EC:2.4.1.134] +xref: EC:2.4.1.134 +xref: MetaCyc:2.4.1.134-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047221 +name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + UDP." [EC:2.4.1.137, MetaCyc:2.4.1.137-RXN] +synonym: "floridoside phosphate synthase activity" EXACT [EC:2.4.1.137] +synonym: "floridoside phosphate synthetase activity" EXACT [EC:2.4.1.137] +synonym: "floridoside-phosphate synthase activity" EXACT [EC:2.4.1.137] +synonym: "FPS" RELATED [EC:2.4.1.137] +synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" EXACT [EC:2.4.1.137] +synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] +synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" EXACT [EC:2.4.1.137] +synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137] +xref: EC:2.4.1.137 +xref: MetaCyc:2.4.1.137-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047222 +name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN] +synonym: "alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] +synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.138] +synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138] +xref: EC:2.4.1.138 +xref: MetaCyc:2.4.1.138-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047223 +name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN] +synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146] +synonym: "elongation 3beta-GalNAc-transferase activity" EXACT [EC:2.4.1.146] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.146] +synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.146] +synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" EXACT [EC:2.4.1.146] +xref: EC:2.4.1.146 +xref: MetaCyc:2.4.1.146-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047224 +name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN] +synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] +synonym: "core 3beta-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] +synonym: "mucin core 3 beta3-GlcNAc-transferase activity" EXACT [EC:2.4.1.147] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.147] +synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.147] +synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.147] +xref: EC:2.4.1.147 +xref: MetaCyc:2.4.1.147-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047225 +name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN] +synonym: "core 4 beta6-GalNAc-transferase activity" EXACT [EC:2.4.1.148] +synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148] +synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.148] +synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.148] +synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148] +xref: EC:2.4.1.148 +xref: MetaCyc:2.4.1.148-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047227 +name: indolylacetyl-myo-inositol galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetyl-myo-inositol + UDP-galactose = 5-O-(indol-3-ylacetyl-myo-inositol)-D-galactoside + UDP." [EC:2.4.1.156, MetaCyc:2.4.1.156-RXN] +synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" EXACT [EC:2.4.1.156] +synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] +synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156] +synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" EXACT [EC:2.4.1.156] +xref: EC:2.4.1.156 +xref: MetaCyc:2.4.1.156-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047228 +name: 1,2-diacylglycerol 3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN] +subset: gosubset_prok +synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] +synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] +synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] +synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157] +synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] +synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157] +xref: EC:2.4.1.157 +xref: MetaCyc:2.4.1.157-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047229 +name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN] +synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.158] +synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] +synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] +synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" EXACT [EC:2.4.1.158] +synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158] +synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158] +xref: EC:2.4.1.158 +xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047230 +name: flavonol-3-O-glucoside L-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN] +synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.159] +synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] +synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159] +xref: EC:2.4.1.159 +xref: MetaCyc:2.4.1.159-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047231 +name: pyridoxine 5'-O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + UDP." [EC:2.4.1.160, MetaCyc:2.4.1.160-RXN] +synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" EXACT [EC:2.4.1.160] +synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] +synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] +synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160] +synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160] +xref: EC:2.4.1.160 +xref: MetaCyc:2.4.1.160-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047232 +name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN] +synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.164] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164] +xref: EC:2.4.1.164 +xref: MetaCyc:2.4.1.164-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047233 +name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN] +synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] +synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165] +xref: EC:2.4.1.165 +xref: MetaCyc:2.4.1.165-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047234 +name: raffinose-raffinose alpha-galactotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN] +subset: gosubset_prok +synonym: "raffinose (raffinose donor) galactosyltransferase activity" EXACT [EC:2.4.1.166] +synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT [] +synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT [] +synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.166] +synonym: "raffinose:raffinose alpha-galactosyltransferase activity" EXACT [EC:2.4.1.166] +xref: EC:2.4.1.166 +xref: MetaCyc:2.4.1.166-RXN +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0047235 +name: sucrose 6F-alpha-galactotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN] +synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT [] +synonym: "sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] +synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] +synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167] +synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] +synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167] +xref: EC:2.4.1.167 +xref: MetaCyc:2.4.1.167-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047236 +name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CH(3)-N(O)=N-CH(2)OH + UDP-D-glucose = cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN] +synonym: "cycasin synthase activity" EXACT [EC:2.4.1.171] +synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.171] +synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] +synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171] +xref: EC:2.4.1.171 +xref: MetaCyc:2.4.1.171-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047237 +name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN] +synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "N-acetylgalactosaminyltransferase I activity" EXACT [] +synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.174] +synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174] +synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174] +xref: EC:2.4.1.174 +xref: MetaCyc:2.4.1.174-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047238 +name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN] +synonym: "chondroitin synthase activity" EXACT [EC:2.4.1.175] +synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "N-acetylgalactosaminyltransferase II activity" EXACT [] +synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] +synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175] +synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" EXACT [EC:2.4.1.175] +xref: EC:2.4.1.175 +xref: MetaCyc:2.4.1.175-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047239 +name: hydroxymandelonitrile glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = taxiphyllin + UDP." [EC:2.4.1.178, MetaCyc:2.4.1.178-RXN] +synonym: "cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.178] +synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] +synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178] +xref: EC:2.4.1.178 +xref: MetaCyc:2.4.1.178-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047240 +name: lactosylceramide beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-1,4-beta-D-glucosyl-R + UDP-galactose = D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R + UDP." [EC:2.4.1.179, MetaCyc:2.4.1.179-RXN] +synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] +synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179] +synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" EXACT [EC:2.4.1.179] +xref: EC:2.4.1.179 +xref: MetaCyc:2.4.1.179-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity + +[Term] +id: GO:0047241 +name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [EC:2.4.1.180, MetaCyc:2.4.1.180-RXN] +synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT [] +synonym: "ManNAcA transferase activity" EXACT [EC:2.4.1.180] +synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" EXACT [EC:2.4.1.180] +synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" EXACT [EC:2.4.1.180] +xref: EC:2.4.1.180 +xref: MetaCyc:2.4.1.180-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047242 +name: hydroxyanthraquinone glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN] +synonym: "anthraquinone-specific glucosyltransferase activity" EXACT [EC:2.4.1.181] +synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] +synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181] +synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" EXACT [EC:2.4.1.181] +xref: EC:2.4.1.181 +xref: MetaCyc:2.4.1.181-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047243 +name: flavanone 7-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN] +synonym: "hesperetin 7-O-glucosyl-transferase activity" EXACT [EC:2.4.1.185] +synonym: "naringenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] +synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] +synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185] +synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185] +xref: EC:2.4.1.185 +xref: MetaCyc:2.4.1.185-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047244 +name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN] +subset: gosubset_prok +synonym: "N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] +synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] +synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] +synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187] +xref: EC:2.4.1.187 +xref: MetaCyc:TEICHOICSYN2-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047245 +name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN] +synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] +synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] +synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188] +synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188] +xref: EC:2.4.1.188 +xref: MetaCyc:2.4.1.188-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047246 +name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolin 7-O-glucuronide + UDP-D-glucuronate = luteolin 7-O-beta-D-diglucuronide + UDP." [EC:2.4.1.190, MetaCyc:2.4.1.190-RXN] +synonym: "LMT activity" RELATED [EC:2.4.1.190] +synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] +synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] +synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190] +synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.190] +xref: EC:2.4.1.190 +xref: MetaCyc:2.4.1.190-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0047247 +name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucuronide + UDP-D-glucuronate = luteolin 7-O-[beta-D-glucuronosyl-(1,2)-beta-D-glucuronide]-4'-O-beta-D-glucuronide + UDP." [EC:2.4.1.191, MetaCyc:2.4.1.191-RXN] +synonym: "LDT" RELATED [EC:2.4.1.191] +synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] +synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] +synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" EXACT [EC:2.4.1.191] +synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191] +synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.191] +xref: EC:2.4.1.191 +xref: MetaCyc:2.4.1.191-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0047248 +name: nuatigenin 3-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol + UDP-D-glucose = (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol 3-O-beta-D-glucoside + UDP." [EC:2.4.1.192, MetaCyc:2.4.1.192-RXN] +synonym: "nuatigenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.192] +synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] +synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192] +synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" EXACT [EC:2.4.1.192] +xref: EC:2.4.1.192 +xref: MetaCyc:2.4.1.192-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047249 +name: sarsapogenin 3-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (25S)-5-beta-spirostan-3-beta-ol + UDP-D-glucose = (25S)-5-beta-spirostan-3-beta-ol 3-O-beta-D-glucoside + UDP." [EC:2.4.1.193, MetaCyc:2.4.1.193-RXN] +synonym: "sarsapogenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.193] +synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] +synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193] +synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" EXACT [EC:2.4.1.193] +xref: EC:2.4.1.193 +xref: MetaCyc:2.4.1.193-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047250 +name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + UDP." [EC:2.4.1.194, MetaCyc:2.4.1.194-RXN] +synonym: "HBA glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "p-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "PHB glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "PHB-O-glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194] +synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194] +xref: EC:2.4.1.194 +xref: MetaCyc:2.4.1.194-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047251 +name: thiohydroximate beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN] +synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "thiohydroximate S-glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "UDPG:thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] +synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195] +xref: EC:2.4.1.195 +xref: MetaCyc:2.4.1.195-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047252 +name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,6-alpha-D-mannosyloligodaccharide + beta-D-mannosylphosphodecaprenol = 1,6-alpha-D-mannosyl-1,6-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN] +synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.199] +synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.199] +xref: EC:2.4.1.199 +xref: MetaCyc:2.4.1.199-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0047253 +name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN] +synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT [] +synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.201] +synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] +synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.201] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201] +xref: EC:2.4.1.201 +xref: MetaCyc:2.4.1.201-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047254 +name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN] +synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] +synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202] +synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" EXACT [EC:2.4.1.202] +xref: EC:2.4.1.202 +xref: MetaCyc:2.4.1.202-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047255 +name: galactogen 6-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN] +synonym: "1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] +synonym: "beta-(1-6)-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] +synonym: "galactogen 6beta-galactosyltransferase activity" EXACT [EC:2.4.1.205] +synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] +synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205] +synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" EXACT [EC:2.4.1.205] +xref: EC:2.4.1.205 +xref: MetaCyc:2.4.1.205-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047256 +name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN] +synonym: "beta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] +synonym: "LA2 synthase activity" EXACT [EC:2.4.1.206] +synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] +synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] +synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206] +xref: EC:2.4.1.206 +xref: MetaCyc:2.4.1.206-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047257 +name: diglucosyl diacylglycerol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN] +synonym: "DGlcDAG synthase activity" EXACT [EC:2.4.1.208] +synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT [] +synonym: "MGlcDAG (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] +synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] +synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208] +xref: EC:2.4.1.208 +xref: MetaCyc:2.4.1.208-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047258 +name: sphingosine beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine + UDP-galactose = psychosine + UDP." [EC:2.4.1.23, MetaCyc:2.4.1.23-RXN] +synonym: "galactosyl-sphingosine transferase activity" EXACT [EC:2.4.1.23] +synonym: "psychosine-UDP galactosyltransferase activity" EXACT [EC:2.4.1.23] +synonym: "psychosine-uridine diphosphate galactosyltransferase activity" EXACT [EC:2.4.1.23] +synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] +synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23] +synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" EXACT [EC:2.4.1.23] +synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" EXACT [EC:2.4.1.23] +xref: EC:2.4.1.23 +xref: MetaCyc:2.4.1.23-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047259 +name: glucomannan 4-beta-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN] +synonym: "GDP-man-beta-mannan manosyltransferase activity" EXACT [EC:2.4.1.32] +synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT [] +synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT [] +synonym: "glucomannan-synthase activity" EXACT [] +xref: EC:2.4.1.32 +xref: MetaCyc:2.4.1.32-RXN +is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity + +[Term] +id: GO:0047260 +name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN] +synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] +synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] +synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] +synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36] +synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36] +synonym: "trehalose phosphate synthase (GDP-forming) activity" EXACT [EC:2.4.1.36] +xref: EC:2.4.1.36 +xref: MetaCyc:2.4.1.36-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047261 +name: steroid N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17-alpha 3-D-glucuronoside + UDP-N-acetyl-D-glucosamine = 17-alpha-(N-acetyl-D-glucosaminyl)estradiol 3-D-glucuronoside + UDP." [EC:2.4.1.39, MetaCyc:2.4.1.39-RXN] +synonym: "hydroxy steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] +synonym: "steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] +synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] +synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39] +xref: EC:2.4.1.39 +xref: MetaCyc:2.4.1.39-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047262 +name: polygalacturonate 4-alpha-galacturonosyltransferase activity +namespace: molecular_function +alt_id: GO:0050375 +def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN] +synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] +synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] +synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43] +xref: EC:2.4.1.43 +xref: MetaCyc:2.4.1.43-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047263 +name: N-acylsphingosine galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN] +synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] +synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] +synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47] +synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47] +xref: EC:2.4.1.47 +xref: MetaCyc:2.4.1.47-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047264 +name: heteroglycan alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: heteroglycan + GDP-mannose = 1,2(or 1,3)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN] +synonym: "GDP mannose alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] +synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48] +synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48] +xref: EC:2.4.1.48 +xref: MetaCyc:2.4.1.48-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0047265 +name: poly(glycerol-phosphate) alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN] +subset: gosubset_prok +synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] +synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] +synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52] +synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52] +xref: EC:2.4.1.52 +xref: MetaCyc:2.4.1.52-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047266 +name: poly(ribitol-phosphate) beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN] +synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] +synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] +synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53] +synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] +synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53] +synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53] +xref: EC:2.4.1.53 +xref: MetaCyc:2.4.1.53-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047267 +name: undecaprenyl-phosphate mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: undecaprenyl phosphate + GDP-mannose = D-mannosyl-1-phosphoundecaprenol + GDP." [EC:2.4.1.54, MetaCyc:2.4.1.54-RXN] +synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] +synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" EXACT [EC:2.4.1.54] +synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" EXACT [EC:2.4.1.54] +synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54] +xref: EC:2.4.1.54 +xref: MetaCyc:2.4.1.54-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0047268 +name: galactinol-raffinose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN] +synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" EXACT [EC:2.4.1.67] +synonym: "stachyose synthetase activity" EXACT [EC:2.4.1.67] +xref: EC:2.4.1.67 +xref: MetaCyc:2.4.1.67-RXN +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0047269 +name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN] +synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] +synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.70] +synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70] +xref: EC:2.4.1.70 +xref: MetaCyc:2.4.1.70-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047270 +name: lipopolysaccharide glucosyltransferase II activity +namespace: molecular_function +def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, MetaCyc:2.4.1.73-RXN] +synonym: "LPS glucosyltransferase II activity" EXACT [] +synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] +synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73] +synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.73] +xref: EC:2.4.1.73 +xref: MetaCyc:2.4.1.73-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047271 +name: glycosaminoglycan galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN] +synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] +synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74] +synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.74] +xref: EC:2.4.1.74 +xref: MetaCyc:2.4.1.74-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047272 +name: phosphopolyprenol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN] +synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] +synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78] +synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] +synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78] +xref: EC:2.4.1.78 +xref: MetaCyc:2.4.1.78-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047273 +name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity +namespace: molecular_function +alt_id: GO:0047226 +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN] +synonym: "beta-3GalNAc-T1 activity" EXACT [EC:2.4.1.79] +synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79] +synonym: "galactosylgalactosylglucosylceramide beta-D- activity" EXACT [EC:2.4.1.79] +synonym: "globoside synthase activity" EXACT [EC:2.4.1.79] +synonym: "globoside synthetase activity" EXACT [EC:2.4.1.79] +synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] +synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] +synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79] +synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] +synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] +synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79] +xref: EC:2.4.1.79 +xref: MetaCyc:2.4.1.79-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047274 +name: galactinol-sucrose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN] +synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] +synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82] +synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT [] +synonym: "galactosyltransferase, galactinol-sucrose" EXACT [] +synonym: "raffinose synthase activity" EXACT [] +xref: EC:2.4.1.82 +xref: MetaCyc:2.4.1.82-RXN +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0047275 +name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN] +synonym: "GalT-4" RELATED [EC:2.4.1.86] +synonym: "paragloboside synthase activity" EXACT [EC:2.4.1.86] +synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] +synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86] +synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.86] +xref: EC:2.4.1.86 +xref: MetaCyc:2.4.1.86-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047276 +name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity +namespace: molecular_function +alt_id: GO:0003946 +def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN] +synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [] +synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT [] +synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87] +xref: EC:2.4.1.87 +xref: MetaCyc:2.4.1.151-RXN +xref: MetaCyc:2.4.1.87-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047277 +name: globoside alpha-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN] +synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88] +synonym: "forssman synthase activity" EXACT [EC:2.4.1.88] +synonym: "globoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] +synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.88] +synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88] +xref: EC:2.4.1.88 +xref: MetaCyc:2.4.1.88-RXN +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047278 +name: bilirubin-glucuronoside glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin-bisglucuronoside + bilirubin." [EC:2.4.1.95, MetaCyc:2.4.1.95-RXN] +synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.95] +synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [EC:2.4.1.95] +synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [EC:2.4.1.95] +xref: EC:2.4.1.95 +xref: MetaCyc:2.4.1.95-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0047279 +name: sn-glycerol-3-phosphate 1-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = alpha-D-galactosyl-(1,1')-sn-glycerol 3-phosphate + UDP." [EC:2.4.1.96, MetaCyc:2.4.1.96-RXN] +synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" EXACT [EC:2.4.1.96] +synonym: "isofloridoside-phosphate synthase activity" EXACT [EC:2.4.1.96] +synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" EXACT [EC:2.4.1.96] +synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] +synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] +synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96] +synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" EXACT [EC:2.4.1.96] +xref: EC:2.4.1.96 +xref: MetaCyc:2.4.1.96-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047280 +name: nicotinamide phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide." [EC:2.4.2.12, MetaCyc:2.4.2.12-RXN] +synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12] +synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12] +synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12] +synonym: "NMN diphosphorylase activity" EXACT [EC:2.4.2.12] +synonym: "NMN pyrophosphorylase activity" EXACT [EC:2.4.2.12] +synonym: "NMN synthetase activity" EXACT [EC:2.4.2.12] +xref: EC:2.4.2.12 +xref: MetaCyc:2.4.2.12-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047281 +name: dioxotetrahydropyrimidine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN] +synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" EXACT [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXACT [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20] +xref: EC:2.4.2.20 +xref: MetaCyc:2.4.2.20-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047282 +name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: streptidine 6-phosphate + dTDP-L-dihydrostreptose = O-1,4-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP." [EC:2.4.2.27, MetaCyc:2.4.2.27-RXN] +subset: gosubset_prok +synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] +synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] +synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27] +xref: EC:2.4.2.27 +xref: MetaCyc:2.4.2.27-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047283 +name: dolichyl-phosphate D-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN] +synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" EXACT [EC:2.4.2.32] +xref: EC:2.4.2.32 +xref: MetaCyc:2.4.2.32-RXN +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0047284 +name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN] +synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33] +xref: EC:2.4.2.33 +xref: MetaCyc:2.4.2.33-RXN +is_a: GO:0042285 ! xylosyltransferase activity + +[Term] +id: GO:0047285 +name: flavonol-3-O-glycoside xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN] +synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.35] +xref: EC:2.4.2.35 +xref: MetaCyc:2.4.2.35-RXN +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0047286 +name: NAD+-diphthamide ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36, MetaCyc:2.4.2.36-RXN] +subset: gosubset_prok +synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36] +synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36] +synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.36] +synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT [] +xref: EC:2.4.2.36 +xref: MetaCyc:2.4.2.36-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047287 +name: lactosylceramide alpha-2,6-N-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN] +synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11] +synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.11] +synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] +synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11] +synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11] +xref: EC:2.4.99.11 +xref: MetaCyc:2.4.99.11-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047288 +name: monosialoganglioside sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN] +synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.2] +xref: EC:2.4.99.2 +xref: MetaCyc:2.4.99.2-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047289 +name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetylneuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP." [EC:2.4.99.5, MetaCyc:2.4.99.5-RXN] +synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.5] +xref: EC:2.4.99.5 +xref: MetaCyc:2.4.99.5-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047290 +name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(alpha-N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, MetaCyc:2.4.99.7-RXN] +synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] +synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT [] +synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] +synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.7] +synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] +synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] +synonym: "neuac-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7] +synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7] +synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7] +synonym: "SIAT7" RELATED [EC:2.4.99.7] +synonym: "ST6GALNAC activity" EXACT [EC:2.4.99.7] +xref: EC:2.4.99.7 +xref: MetaCyc:2.4.99.7-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047291 +name: lactosylceramide alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN] +synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9] +synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.9] +synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.9] +synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" EXACT [EC:2.4.99.9] +synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" EXACT [EC:2.4.99.9] +synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9] +synonym: "ganglioside GM3 synthase activity" EXACT [EC:2.4.99.9] +synonym: "ganglioside GM3 synthetase activity" EXACT [EC:2.4.99.9] +synonym: "GM3 synthase activity" EXACT [EC:2.4.99.9] +synonym: "GM3 synthetase activity" EXACT [EC:2.4.99.9] +synonym: "SAT 1" RELATED [EC:2.4.99.9] +xref: EC:2.4.99.9 +xref: MetaCyc:2.4.99.9-RXN +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047292 +name: trihydroxypterocarpan dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + pyrophosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN] +synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] +synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" EXACT [EC:2.5.1.36] +synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36] +synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" EXACT [EC:2.5.1.36] +xref: EC:2.5.1.36 +xref: MetaCyc:2.5.1.36-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047293 +name: 4-hydroxybenzoate nonaprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + pyrophosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN] +synonym: "4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] +synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39] +synonym: "p-hydroxybenzoate dimethylallyltransferase activity" EXACT [EC:2.5.1.39] +synonym: "p-hydroxybenzoate polyprenyltransferase activity" EXACT [EC:2.5.1.39] +synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" EXACT [EC:2.5.1.39] +synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39] +synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39] +xref: EC:2.5.1.39 +xref: MetaCyc:2.5.1.39-RXN +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0047294 +name: phosphoglycerol geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glyceryl phosphate + geranylgeranyl-PP = sn-3-O-(geranylgeranyl)glyceryl 1-phosphate + diphosphate." [EC:2.5.1.41, MetaCyc:2.5.1.41-RXN] +synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] +synonym: "geranylgeranyl-transferase activity" EXACT [EC:2.5.1.41] +synonym: "glycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41] +xref: EC:2.5.1.41 +xref: MetaCyc:2.5.1.41-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047295 +name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + geranylgeranyl-PP = 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, MetaCyc:2.5.1.42-RXN] +synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] +synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42] +synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42] +xref: EC:2.5.1.42 +xref: MetaCyc:2.5.1.42-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047296 +name: homospermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN] +subset: gosubset_prok +synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44] +xref: EC:2.5.1.44 +xref: MetaCyc:2.5.1.44-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047297 +name: asparagine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN] +synonym: "asparagine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] +synonym: "asparagine-keto acid aminotransferase activity" EXACT [EC:2.6.1.14] +synonym: "asparagine-oxo-acid aminotransferase activity" EXACT [] +synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14] +xref: EC:2.6.1.14 +xref: MetaCyc:2.6.1.14-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047298 +name: (S)-3-amino-2-methylpropionate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + (S)-3-amino-2-methylpropanoate = L-glutamate + methylmalonate-semialdehyde." [EC:2.6.1.22, MetaCyc:2.6.1.22-RXN] +subset: gosubset_prok +synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.22] +synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT [] +synonym: "beta-aminobutyric transaminase activity" EXACT [EC:2.6.1.22] +synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.22] +synonym: "L-3-aminoisobutyrate aminotransferase activity" EXACT [EC:2.6.1.22] +synonym: "L-3-aminoisobutyrate transaminase activity" EXACT [EC:2.6.1.22] +synonym: "L-3-aminoisobutyric aminotransferase activity" EXACT [EC:2.6.1.22] +synonym: "L-AIBAT activity" EXACT [EC:2.6.1.22] +xref: EC:2.6.1.22 +xref: MetaCyc:2.6.1.22-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047299 +name: tryptophan-phenylpyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylpyruvate + L-tryptophan = L-phenylalanine + indolepyruvate." [EC:2.6.1.28, MetaCyc:2.6.1.28-RXN] +synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" EXACT [EC:2.6.1.28] +synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] +synonym: "tryptophan--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28] +synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT [] +xref: EC:2.6.1.28 +xref: MetaCyc:2.6.1.28-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047300 +name: pyridoxamine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + pyridoxamine = L-alanine + pyridoxal." [EC:2.6.1.30, MetaCyc:2.6.1.30-RXN] +synonym: "pyridoxamine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] +synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT [] +synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30] +synonym: "pyridoxamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.30] +synonym: "pyridoxamineu-pyruvic transaminase activity" EXACT [EC:2.6.1.30] +xref: EC:2.6.1.30 +xref: MetaCyc:2.6.1.30-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047301 +name: valine-3-methyl-2-oxovalerate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-3-methyl-valerate + L-valine = L-iso-leucine + 2-keto-isovalerate." [EC:2.6.1.32, MetaCyc:2.6.1.32-RXN] +synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" EXACT [EC:2.6.1.32] +synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" EXACT [EC:2.6.1.32] +synonym: "valine--isoleucine aminotransferase activity" EXACT [EC:2.6.1.32] +synonym: "valine--isoleucine transaminase activity" EXACT [EC:2.6.1.32] +synonym: "valine-2-keto-methylvalerate aminotransferase activity" EXACT [EC:2.6.1.32] +synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT [] +xref: EC:2.6.1.32 +xref: MetaCyc:2.6.1.32-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047302 +name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose." [EC:2.6.1.34, MetaCyc:2.6.1.34-RXN] +synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.34] +synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [] +synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT [] +synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.34] +xref: EC:2.6.1.34 +xref: MetaCyc:2.6.1.34-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047303 +name: glycine-oxaloacetate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetic acid + L-glycine = L-aspartate + glyoxylate." [EC:2.6.1.35, MetaCyc:2.6.1.35-RXN] +synonym: "glycine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] +synonym: "glycine-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.35] +synonym: "glycine-oxaloacetate aminotransferase activity" EXACT [] +synonym: "glycine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35] +xref: EC:2.6.1.35 +xref: MetaCyc:2.6.1.35-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047304 +name: 2-aminoethylphosphonate-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + (2-aminoethyl)phosphonate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, MetaCyc:2.6.1.37-RXN] +subset: gosubset_prok +synonym: "(2-aminoethyl)phosphonate aminotransferase activity" EXACT [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonate transaminase activity" EXACT [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" EXACT [EC:2.6.1.37] +synonym: "2-aminoethylphosphonate aminotransferase activity" EXACT [EC:2.6.1.37] +synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37] +synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT [] +xref: EC:2.6.1.37 +xref: MetaCyc:2.6.1.37-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047305 +name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity +namespace: molecular_function +alt_id: GO:0047314 +def: "Catalysis of the reaction: pyruvate + (R)-3-amino-2-methylpropanoate = L-alanine + methylmalonate-semialdehyde." [EC:2.6.1.40, MetaCyc:2.6.1.40-RXN] +comment: Note that this function was EC:2.6.1.61. +synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT [] +synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT [] +synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] +synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT [] +synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] +synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT [] +synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] +synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] +synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] +synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40] +synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" EXACT [EC:2.6.1.40] +synonym: "D-AIBAT activity" EXACT [EC:2.6.1.40] +synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40] +xref: EC:2.6.1.40 +xref: MetaCyc:2.6.1.40-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047306 +name: D-methionine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + D-methionine = L-alanine + 2-keto-4-methylthiobutyrate." [EC:2.6.1.41, MetaCyc:2.6.1.41-RXN] +synonym: "D-methionine aminotransferase activity" EXACT [EC:2.6.1.41] +synonym: "D-methionine transaminase activity" EXACT [EC:2.6.1.41] +synonym: "D-methionine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] +synonym: "D-methionine-pyruvate aminotransferase activity" EXACT [] +synonym: "D-methionine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.41] +xref: EC:2.6.1.41 +xref: MetaCyc:2.6.1.41-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047307 +name: diaminobutyrate-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + L-2,4-diaminobutanoate = L-aspartate-semialdehyde + L-alanine." [EC:2.6.1.46, MetaCyc:2.6.1.46-RXN] +subset: gosubset_prok +synonym: "diaminobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] +synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT [] +synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.46] +synonym: "L-diaminobutyric acid transaminase activity" EXACT [EC:2.6.1.46] +xref: EC:2.6.1.46 +xref: MetaCyc:2.6.1.46-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047308 +name: alanine-oxomalonate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxomalonate + L-alanine = aminomalonate + pyruvate." [EC:2.6.1.47, MetaCyc:2.6.1.47-RXN] +synonym: "alanine--oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] +synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" EXACT [EC:2.6.1.47] +synonym: "alanine-oxomalonate aminotransferase activity" EXACT [] +synonym: "L-alanine-ketomalonate transaminase activity" EXACT [EC:2.6.1.47] +synonym: "L-alanine:oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47] +xref: EC:2.6.1.47 +xref: MetaCyc:2.6.1.47-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047309 +name: dihydroxyphenylalanine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-dihydroxy-phenylalanine = L-glutamate + 3,4-dihydroxyphenylpyruvate." [EC:2.6.1.49, MetaCyc:2.6.1.49-RXN] +synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.49] +synonym: "aspartate-DOPP transaminase (ADT)" EXACT [EC:2.6.1.49] +synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT [] +synonym: "dopa aminotransferase activity" EXACT [EC:2.6.1.49] +synonym: "DOPA aminotransferase activity" EXACT [EC:2.6.1.49] +synonym: "dopa transaminase activity" EXACT [EC:2.6.1.49] +synonym: "glutamate-DOPP transaminase (GDT)" EXACT [EC:2.6.1.49] +synonym: "L-dopa transaminase activity" EXACT [EC:2.6.1.49] +synonym: "phenylalanine-DOPP transaminase (PDT)" EXACT [EC:2.6.1.49] +xref: EC:2.6.1.49 +xref: MetaCyc:2.6.1.49-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047310 +name: glutamine-scyllo-inositol transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-myo-inositol + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-keto-glutaramate." [EC:2.6.1.50, MetaCyc:2.6.1.50-RXN] +subset: gosubset_prok +synonym: "glutamine scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] +synonym: "glutamine--scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50] +synonym: "glutamine--scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] +synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT [] +synonym: "glutamine-scyllo-inosose transaminase activity" EXACT [] +synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" EXACT [EC:2.6.1.50] +synonym: "L-glutamine-scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50] +synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" EXACT [EC:2.6.1.50] +xref: EC:2.6.1.50 +xref: MetaCyc:2.6.1.50-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047311 +name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol = L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol." [EC:2.6.1.56, MetaCyc:2.6.1.56-RXN] +synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT [] +synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] +synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" EXACT [EC:2.6.1.56] +synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" EXACT [EC:2.6.1.56] +xref: EC:2.6.1.56 +xref: MetaCyc:2.6.1.56-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047312 +name: phenylalanine(histidine) transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN] +synonym: "histidine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] +synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] +synonym: "L-phenylalanine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] +synonym: "phenylalanine (histidine) aminotransferase activity" EXACT [EC:2.6.1.58] +synonym: "phenylalanine(histidine) aminotransferase activity" EXACT [] +synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" EXACT [EC:2.6.1.58] +xref: EC:2.6.1.58 +xref: MetaCyc:2.6.1.58-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047313 +name: aromatic-amino-acid-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN] +synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] +synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT [] +synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60] +xref: EC:2.6.1.60 +xref: MetaCyc:2.6.1.60-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047315 +name: kynurenine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + kynurenine = L-glycine + 4-(2-aminophenyl)-2,4-dioxobutanoate." [EC:2.6.1.63, MetaCyc:2.6.1.63-RXN] +synonym: "kynurenine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.63] +synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT [] +synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" EXACT [EC:2.6.1.63] +xref: EC:2.6.1.63 +xref: MetaCyc:2.6.1.63-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047316 +name: glutamine-phenylpyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylpyruvate + L-glutamine = L-phenylalanine + 2-keto-glutaramate." [EC:2.6.1.64, MetaCyc:2.6.1.64-RXN] +synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64] +synonym: "glutamine--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] +synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT [] +synonym: "L-glutamine:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64] +xref: EC:2.6.1.64 +xref: MetaCyc:2.6.1.64-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047317 +name: N6-acetyl-beta-lysine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN] +synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.65] +synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] +synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65] +synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT [] +xref: EC:2.6.1.65 +xref: MetaCyc:2.6.1.65-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047319 +name: aspartate-phenylpyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetic acid." [EC:2.6.1.70, MetaCyc:2.6.1.70-RXN] +synonym: "aspartate--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] +synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT [] +synonym: "L-aspartate:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70] +xref: EC:2.6.1.70 +xref: MetaCyc:2.6.1.70-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047320 +name: D-4-hydroxyphenylglycine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = L-glutamate + 4-hydroxyphenylglyoxylate." [EC:2.6.1.72, MetaCyc:2.6.1.72-RXN] +synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT [] +synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.72] +synonym: "D-hydroxyphenylglycine aminotransferase activity" EXACT [EC:2.6.1.72] +xref: EC:2.6.1.72 +xref: MetaCyc:2.6.1.72-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047321 +name: diphosphate-protein phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = pyrophosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN] +synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1] +synonym: "DiPPT" RELATED [EC:2.7.99.1] +synonym: "pyrophosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] +synonym: "pyrophosphate:protein phosphotransferase activity" EXACT [EC:2.7.99.1] +synonym: "triphosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1] +synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" EXACT [EC:2.7.99.1] +xref: EC:2.7.99.1 +xref: MetaCyc:2.7.99.1-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047322 +name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] +synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] +synonym: "AMPK" RELATED [EC:2.7.11.31] +synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" EXACT [EC:2.7.11.31] +synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] +synonym: "HMG-CoA reductase kinase activity" EXACT [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" EXACT [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" EXACT [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" EXACT [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31] +synonym: "reductase kinase activity" BROAD [EC:2.7.11.31] +synonym: "STK29" RELATED [EC:2.7.11.31] +xref: EC:2.7.11.31 +xref: MetaCyc:2.7.1.109-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047323 +name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" EXACT [EC:2.7.11.4] +synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT [] +synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.4] +synonym: "BCK" RELATED [EC:2.7.11.4] +synonym: "BCKD kinase activity" EXACT [EC:2.7.11.4] +synonym: "BCODH kinase activity" EXACT [EC:2.7.11.4] +synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] +synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] +synonym: "branched-chain keto acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4] +synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.4] +synonym: "STK2" RELATED [EC:2.7.11.4] +xref: EC:2.7.11.4 +xref: MetaCyc:2.7.11.4-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047324 +name: phosphoenolpyruvate-glycerone phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroxy-acetone + phosphoenolpyruvate = dihydroxy-acetone-phosphate + pyruvate." [EC:2.7.1.121, MetaCyc:2.7.1.121-RXN] +synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" EXACT [EC:2.7.1.121] +xref: EC:2.7.1.121 +xref: MetaCyc:2.7.1.121-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047325 +name: inositol tetrakisphosphate 1-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN] +synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" EXACT [EC:2.7.1.134] +synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] +synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] +synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.134] +synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.134] +synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.134] +synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT [] +synonym: "inositol-tetrakisphosphate 1-kinase activity" EXACT [] +synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] +synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] +xref: EC:2.7.1.134 +xref: MetaCyc:2.7.1.134-RXN +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0047326 +name: inositol tetrakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN] +synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT [] +synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.140] +synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT [] +synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT [] +xref: EC:2.7.1.140 +xref: MetaCyc:2.7.1.140-RXN +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0047327 +name: glycerol-3-phosphate-glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + glycerol-3-phosphate = glucose-6-phosphate + glycerol." [EC:2.7.1.142, MetaCyc:2.7.1.142-RXN] +synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.142] +xref: EC:2.7.1.142 +xref: MetaCyc:2.7.1.142-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047328 +name: acyl-phosphate-hexose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN] +synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.61] +synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61] +xref: EC:2.7.1.61 +xref: MetaCyc:2.7.1.61-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047329 +name: phosphoramidate-hexose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN] +synonym: "phosphoramidate-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] +synonym: "phosphoramidate:hexose 1-phosphotransferase activity" EXACT [EC:2.7.1.62] +synonym: "phosphoramidic-hexose transphosphorylase activity" EXACT [EC:2.7.1.62] +xref: EC:2.7.1.62 +xref: MetaCyc:2.7.1.62-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047330 +name: polyphosphate-glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN] +subset: gosubset_prok +synonym: "polyphosphate glucokinase activity" EXACT [EC:2.7.1.63] +synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.63] +synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] +synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63] +xref: EC:2.7.1.63 +xref: MetaCyc:2.7.1.63-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047331 +name: diphosphate-glycerol phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + pyrophosphate = phosphate + glycerol-3-phosphate." [EC:2.7.1.79, MetaCyc:2.7.1.79-RXN] +synonym: "diphosphate:glycerol 1-phosphotransferase activity" EXACT [EC:2.7.1.79] +synonym: "PPi-glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] +synonym: "pyrophosphate--glycerol phosphotransferase activity" EXACT [EC:2.7.1.79] +xref: EC:2.7.1.79 +xref: MetaCyc:2.7.1.79-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047332 +name: diphosphate-serine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + pyrophosphate = phosphate + 3-phospho-serine." [EC:2.7.1.80, MetaCyc:2.7.1.80-RXN] +synonym: "diphosphate:L-serine O-phosphotransferase activity" EXACT [EC:2.7.1.80] +synonym: "pyrophosphate--serine phosphotransferase activity" EXACT [EC:2.7.1.80] +synonym: "pyrophosphate-L-serine phosphotransferase activity" EXACT [EC:2.7.1.80] +xref: EC:2.7.1.80 +xref: MetaCyc:2.7.1.80-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047333 +name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrostreptomycin 6-phosphate + ATP = dihydrostreptomycin 3'-alpha-6-bisphosphate + ADP." [EC:2.7.1.88, MetaCyc:2.7.1.88-RXN] +synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] +synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88] +synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.88] +synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" EXACT [EC:2.7.1.88] +xref: EC:2.7.1.88 +xref: MetaCyc:2.7.1.88-RXN +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0047334 +name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN] +subset: gosubset_prok +synonym: "6-phosphofructokinase (diphosphate) activity" EXACT [EC:2.7.1.90] +synonym: "6-phosphofructokinase (pyrophosphate) activity" EXACT [EC:2.7.1.90] +synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] +synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] +synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.90] +synonym: "inorganic pyrophosphate-phosphofructokinase activity" EXACT [EC:2.7.1.90] +synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90] +synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90] +synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" EXACT [EC:2.7.1.90] +synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" EXACT [EC:2.7.1.90] +xref: EC:2.7.1.90 +xref: MetaCyc:2.7.1.90-RXN +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0047335 +name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN] +synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] +synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] +synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17] +xref: EC:2.7.4.17 +xref: MetaCyc:2.7.4.17-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047336 +name: 5-methyldeoxycytidine-5'-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxy-5-methylcytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP." [EC:2.7.4.19, MetaCyc:2.7.4.19-RXN] +synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" EXACT [EC:2.7.4.19] +xref: EC:2.7.4.19 +xref: MetaCyc:2.7.4.19-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047337 +name: dolichyl-diphosphate-polyphosphate phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN] +synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] +synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20] +xref: EC:2.7.4.20 +xref: MetaCyc:2.7.4.20-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047338 +name: UTP:xylose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN] +synonym: "UDP-xylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] +synonym: "uridine diphosphoxylose pyrophosphorylase activity" EXACT [EC:2.7.7.11] +synonym: "uridylyltransferase, xylose 1-phosphate" EXACT [EC:2.7.7.11] +synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] +synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] +synonym: "xylose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] +synonym: "xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11] +xref: EC:2.7.7.11 +xref: MetaCyc:2.7.7.11-RXN +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0047339 +name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity +namespace: molecular_function +alt_id: GO:0047340 +def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN] +synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] +synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28] +synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW [] +synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] +synonym: "hexose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.28] +synonym: "hexose 1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] +synonym: "hexose nucleotidylating enzyme activity" EXACT [EC:2.7.7.28] +synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW [] +synonym: "NDP hexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] +synonym: "NDP-hexose diphosphorylase activity" EXACT [] +synonym: "NDP-hexose pyrophosphorylase activity" EXACT [] +synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] +synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] +synonym: "nucleoside diphosphohexose pyrophosphorylase activity" EXACT [EC:2.7.7.28] +synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28] +xref: EC:2.7.7.28 +xref: MetaCyc:2.7.7.28-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047341 +name: fucose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fucose 1-phosphate + GTP = guanosine diphosphate fucose + diphosphate." [EC:2.7.7.30, MetaCyc:2.7.7.30-RXN] +synonym: "GDP fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] +synonym: "GDP-fucose diphosphorylase activity" EXACT [EC:2.7.7.30] +synonym: "GDP-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] +synonym: "GDP-L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] +synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] +synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30] +synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30] +xref: EC:2.7.7.30 +xref: MetaCyc:2.7.7.30-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047342 +name: galactose-1-phosphate thymidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-galactose-1-phosphate + dTTP = dTDP-D-galactose + diphosphate." [EC:2.7.7.32, MetaCyc:2.7.7.32-RXN] +synonym: "dTDP galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] +synonym: "dTDP-galactose diphosphorylase activity" EXACT [EC:2.7.7.32] +synonym: "dTDP-galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] +synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] +synonym: "galactose 1-phosphate thymidylyl transferase activity" EXACT [EC:2.7.7.32] +synonym: "thymidine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.32] +synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32] +xref: EC:2.7.7.32 +xref: MetaCyc:2.7.7.32-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047343 +name: glucose-1-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucose-1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, MetaCyc:2.7.7.33-RXN] +subset: gosubset_prok +synonym: "CDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] +synonym: "CDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.33] +synonym: "CDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] +synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] +synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33] +synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT [] +synonym: "cytidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] +synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] +synonym: "cytidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.33] +xref: EC:2.7.7.33 +xref: MetaCyc:2.7.7.33-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047344 +name: glucose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucose-1-phosphate + GTP = GDP-D-glucose + diphosphate." [EC:2.7.7.34, MetaCyc:2.7.7.34-RXN] +synonym: "GDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] +synonym: "GDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.34] +synonym: "GDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] +synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.34] +synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "guanosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.34] +xref: EC:2.7.7.34 +xref: MetaCyc:2.7.7.34-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047345 +name: ribose-5-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribose-5-phosphate + ADP = phosphate + adenosine diphosphate ribose." [EC:2.7.7.35, MetaCyc:2.7.7.35-RXN] +synonym: "adenosine diphosphoribose phosphorylase activity" EXACT [EC:2.7.7.35] +synonym: "ADP ribose phosphorylase activity" EXACT [EC:2.7.7.35] +synonym: "ADP-ribose phosphorylase activity" EXACT [EC:2.7.7.35] +synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.35] +synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT [] +xref: EC:2.7.7.35 +xref: MetaCyc:2.7.7.35-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047346 +name: aldose-1-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN] +synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] +synonym: "adenosine diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.36] +synonym: "ADP sugar phosphorylase activity" EXACT [EC:2.7.7.36] +synonym: "ADP-aldose phosphorylase activity" EXACT [EC:2.7.7.36] +synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36] +synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT [] +synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.36] +synonym: "ADPaldose phosphorylase activity" EXACT [EC:2.7.7.36] +synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36] +xref: EC:2.7.7.36 +xref: MetaCyc:2.7.7.36-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047347 +name: aldose-1-phosphate nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN] +subset: gosubset_prok +synonym: "glucose 1-phosphate inosityltransferase activity" EXACT [EC:2.7.7.37] +synonym: "NDP sugar phosphorylase activity" EXACT [EC:2.7.7.37] +synonym: "NDP-aldose phosphorylase activity" EXACT [EC:2.7.7.37] +synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37] +synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] +synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] +synonym: "NDPaldose phosphorylase activity" EXACT [EC:2.7.7.37] +synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] +synonym: "nucleoside diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.37] +synonym: "sugar nucleotide phosphorylase activity" EXACT [EC:2.7.7.37] +synonym: "sugar phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37] +synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37] +xref: EC:2.7.7.37 +xref: MetaCyc:2.7.7.37-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047348 +name: glycerol-3-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol-3-phosphate + CTP = CDPglycerol + diphosphate." [EC:2.7.7.39, MetaCyc:2.7.7.39-RXN] +subset: gosubset_prok +synonym: "CDP-glycerol diphosphorylase activity" EXACT [EC:2.7.7.39] +synonym: "CDP-glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] +synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] +synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT [] +synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39] +synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] +synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39] +synonym: "Gro-PCT" RELATED [EC:2.7.7.39] +xref: EC:2.7.7.39 +xref: MetaCyc:2.7.7.39-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047349 +name: D-ribitol-5-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, MetaCyc:2.7.7.40-RXN] +subset: gosubset_prok +synonym: "CDP ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] +synonym: "CDP-ribitol diphosphorylase activity" EXACT [EC:2.7.7.40] +synonym: "CDP-ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] +synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT [] +synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] +synonym: "cytidine diphosphoribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40] +synonym: "ribitol 5-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.40] +xref: EC:2.7.7.40 +xref: MetaCyc:2.7.7.40-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047350 +name: glucuronate-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = UDP-D-glucuronate + diphosphate." [EC:2.7.7.44, MetaCyc:2.7.7.44-RXN] +synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] +synonym: "UDP-glucuronate pyrophosphorylase activity" EXACT [EC:2.7.7.44] +synonym: "UDP-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44] +synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" EXACT [EC:2.7.7.44] +synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" EXACT [EC:2.7.7.44] +synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT [] +xref: EC:2.7.7.44 +xref: MetaCyc:2.7.7.44-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047351 +name: guanosine-triphosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 GTP = P1,P4-bis(5'-guanosyl) tetraphosphate + diphosphate." [EC:2.7.7.45, MetaCyc:2.7.7.45-RXN] +synonym: "GTP:GTP guanylyltransferase activity" EXACT [] +xref: EC:2.7.7.45 +xref: MetaCyc:2.7.7.45-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047352 +name: adenylylsulfate-ammonia adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + APS = SO4(2-) (sulfate) + adenosine 5'-phosphoramidate." [EC:2.7.7.51, MetaCyc:2.7.7.51-RXN] +synonym: "adenylylsulfate:ammonia adenylyltransferase activity" EXACT [EC:2.7.7.51] +synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT [] +synonym: "APSAT" RELATED [EC:2.7.7.51] +xref: EC:2.7.7.51 +xref: MetaCyc:2.7.7.51-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047353 +name: N-methylphosphoethanolamine cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamin + diphosphate." [EC:2.7.7.57, MetaCyc:2.7.7.57-RXN] +synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] +synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT [] +synonym: "CTP:P-MEA cytidylyltransferase activity" EXACT [EC:2.7.7.57] +synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57] +xref: EC:2.7.7.57 +xref: MetaCyc:2.7.7.57-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047354 +name: sphingosine cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine + CDP-choline = sphingosyl-phosphocholine + CMP." [EC:2.7.8.10, MetaCyc:2.7.8.10-RXN] +synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] +synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] +synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10] +synonym: "phosphorylcholine-sphingosine transferase activity" EXACT [EC:2.7.8.10] +synonym: "sphingosine choline phosphotransferase activity" EXACT [] +xref: EC:2.7.8.10 +xref: MetaCyc:2.7.8.10-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047355 +name: CDP-glycerol glycerophosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN] +subset: gosubset_prok +synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" EXACT [EC:2.7.8.12] +synonym: "CDPglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] +synonym: "CGPTase activity" EXACT [EC:2.7.8.12] +synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12] +synonym: "glycerophosphate synthetase activity" EXACT [EC:2.7.8.12] +synonym: "poly(glycerol phosphate) polymerase activity" EXACT [EC:2.7.8.12] +synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12] +synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12] +xref: EC:2.7.8.12 +xref: MetaCyc:2.7.8.12-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047356 +name: CDP-ribitol ribitolphosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN] +subset: gosubset_prok +synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] +synonym: "CDPribitol ribitolphosphotransferase activity" EXACT [EC:2.7.8.14] +synonym: "poly(ribitol phosphate) synthetase activity" EXACT [EC:2.7.8.14] +synonym: "polyribitol phosphate polymerase activity" EXACT [EC:2.7.8.14] +synonym: "polyribitol phosphate synthetase activity" EXACT [EC:2.7.8.14] +synonym: "teichoate synthase activity" EXACT [EC:2.7.8.14] +synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14] +synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] +xref: EC:2.7.8.14 +xref: MetaCyc:2.7.8.14-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047357 +name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + UDP-galactose = UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, MetaCyc:2.7.8.18-RXN] +synonym: "galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] +synonym: "galactosyl phosphotransferase activity" EXACT [EC:2.7.8.18] +synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] +synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] +synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18] +synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18] +xref: EC:2.7.8.18 +xref: MetaCyc:2.7.8.18-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047358 +name: UDP-glucose-glycoprotein glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN] +synonym: "Glc-phosphotransferase activity" EXACT [EC:2.7.8.19] +synonym: "GlcPTase activity" EXACT [EC:2.7.8.19] +synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] +synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] +synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" EXACT [EC:2.7.8.19] +synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19] +synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19] +xref: EC:2.7.8.19 +xref: MetaCyc:2.7.8.19-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047359 +name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN] +synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" EXACT [EC:2.7.8.22] +synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22] +xref: EC:2.7.8.22 +xref: MetaCyc:2.7.8.22-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047360 +name: undecaprenyl-phosphate galactose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: undecaprenyl phosphate + UDP-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, MetaCyc:2.7.8.6-RXN] +subset: gosubset_prok +synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] +synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] +synonym: "Poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6] +synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" EXACT [EC:2.7.8.6] +synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6] +synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" EXACT [EC:2.7.8.6] +xref: EC:2.7.8.6 +xref: MetaCyc:2.7.8.6-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047361 +name: phosphomannan mannosephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN] +synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" EXACT [EC:2.7.8.9] +xref: EC:2.7.8.9 +xref: MetaCyc:2.7.8.9-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047362 +name: thiosulfate-dithiol sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dithioerythritol + S2O3(2-) (thiosulfate) = H2S + dithioerythritol disulfide + SO3(2-) (sulfite)." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN] +synonym: "thiosulfate reductase activity" EXACT [EC:2.8.1.5] +synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" EXACT [EC:2.8.1.5] +synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT [] +synonym: "TSR" RELATED [EC:2.8.1.5] +xref: EC:2.8.1.5 +xref: MetaCyc:2.8.1.5-RXN +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0047363 +name: triglucosylalkylacylglycerol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN] +synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" EXACT [EC:2.8.2.19] +synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT [] +synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19] +xref: EC:2.8.2.19 +xref: MetaCyc:2.8.2.19-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047364 +name: desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: desulfoglucotropeolin + 3'-phosphoadenosine 5'-phosphosulfate = glucotropeolin + adenosine 3',5'-bisphosphate." [EC:2.8.2.24, MetaCyc:2.8.2.24-RXN] +synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] +synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] +synonym: "desulphoglucosinolate sulphotransferase activity" EXACT [] +synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24] +xref: EC:2.8.2.24 +xref: MetaCyc:2.8.2.24-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047365 +name: quercetin-3-sulfate 3'-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3'-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.26, MetaCyc:2.8.2.26-RXN] +synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] +synonym: "3'-sulfotransferase activity" EXACT [EC:2.8.2.26] +synonym: "flavonol 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] +synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26] +synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.26 +xref: MetaCyc:2.8.2.26-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047366 +name: quercetin-3-sulfate 4'-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,4'-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.27, MetaCyc:2.8.2.27-RXN] +synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] +synonym: "flavonol 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] +synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27] +synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.27 +xref: MetaCyc:2.8.2.27-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047367 +name: quercetin-3,3'-bissulfate 7-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN] +synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] +synonym: "7-sulfotransferase activity" EXACT [EC:2.8.2.28] +synonym: "flavonol 7-sulfotransferase activity" EXACT [EC:2.8.2.28] +synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28] +synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.28 +xref: MetaCyc:2.8.2.28-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047368 +name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine 4-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = UDP-N-acetyl-D-galactosamine 4,6-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.7, MetaCyc:2.8.2.7-RXN] +synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" EXACT [EC:2.8.2.7] +synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT [] +synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] +synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7] +xref: EC:2.8.2.7 +xref: MetaCyc:2.8.2.7-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047369 +name: succinate-hydroxymethylglutarate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN] +synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" EXACT [EC:2.8.3.13] +synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.3.13] +synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13] +xref: EC:2.8.3.13 +xref: MetaCyc:2.8.3.13-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047370 +name: succinate-citramalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [EC:2.8.3.7, MetaCyc:2.8.3.7-RXN] +synonym: "citramalate coenzyme A-transferase activity" EXACT [EC:2.8.3.7] +synonym: "itaconate CoA-transferase activity" EXACT [EC:2.8.3.7] +synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [EC:2.8.3.7] +synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.7] +xref: EC:2.8.3.7 +xref: MetaCyc:2.8.3.7-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047371 +name: butyrate-acetoacetate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetate + butyryl-CoA = acetoacetyl-CoA + butyrate." [EC:2.8.3.9, MetaCyc:2.8.3.9-RXN] +subset: gosubset_prok +synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] +synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" EXACT [EC:2.8.3.9] +synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9] +xref: EC:2.8.3.9 +xref: MetaCyc:2.8.3.9-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047372 +name: acylglycerol lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] +subset: gosubset_prok +synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23] +synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23] +synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23] +synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23] +synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23] +synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23] +synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23] +synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23] +synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23] +xref: EC:3.1.1.23 +xref: MetaCyc:3.1.1.23-RXN +xref: Reactome:83299 +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0016298 ! lipase activity + +[Term] +id: GO:0047373 +name: acetoxybutynylbithiophene deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 5-(4-acetoxybut-1-ynyl)-2-2'-bithiophene = acetate + 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene." [EC:3.1.1.54, MetaCyc:3.1.1.54-RXN] +synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" EXACT [EC:3.1.1.54] +synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" EXACT [EC:3.1.1.54] +synonym: "acetoxybutynylbithiophene esterase activity" EXACT [EC:3.1.1.54] +xref: EC:3.1.1.54 +xref: MetaCyc:3.1.1.54-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047374 +name: methylumbelliferyl-acetate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = acetate + 4-methylumbelliferone." [EC:3.1.1.56, MetaCyc:3.1.1.56-RXN] +synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" EXACT [EC:3.1.1.56] +synonym: "esterase D activity" RELATED [EC:3.1.1.56] +xref: EC:3.1.1.56 +xref: MetaCyc:3.1.1.56-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047375 +name: N-acetylgalactosaminoglycan deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN] +synonym: "N-acetyl galactosaminoglycan deacetylase activity" EXACT [EC:3.1.1.58] +synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" EXACT [EC:3.1.1.58] +synonym: "polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] +synonym: "Vi-polysaccharide deacetylase activity" EXACT [EC:3.1.1.58] +xref: EC:3.1.1.58 +xref: MetaCyc:3.1.1.58-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047376 +name: all-trans-retinyl-palmitate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + retinol-palmitate = palmitate + retinol." [EC:3.1.1.64, MetaCyc:3.1.1.64-RXN] +synonym: "all-trans-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.64] +xref: EC:3.1.1.64 +xref: MetaCyc:3.1.1.64-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047377 +name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene = acetate + 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene." [EC:3.1.1.66, MetaCyc:3.1.1.66-RXN] +synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" EXACT [EC:3.1.1.66] +synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" EXACT [EC:3.1.1.66] +synonym: "diacetoxybutynylbithiophene acetate esterase activity" EXACT [EC:3.1.1.66] +xref: EC:3.1.1.66 +xref: MetaCyc:3.1.1.66-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047378 +name: acetylalkylglycerol acetylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 2-acetyl-1-alkyl-sn-glycerol = acetate + 1-alkyl-sn-glycerol." [EC:3.1.1.71, MetaCyc:3.1.1.71-RXN] +synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] +synonym: "alkylacetylglycerol acetylhydrolase activity" EXACT [EC:3.1.1.71] +xref: EC:3.1.1.71 +xref: MetaCyc:3.1.1.71-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047379 +name: ADP-dependent short-chain-acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN] +synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] +synonym: "propionyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] +synonym: "propionyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] +synonym: "propionyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] +synonym: "short-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18] +synonym: "short-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18] +synonym: "short-chain acyl-CoA thioesterase activity" EXACT [EC:3.1.2.18] +xref: EC:3.1.2.18 +xref: MetaCyc:3.1.2.18-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047380 +name: ADP-dependent medium-chain-acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN] +subset: gosubset_prok +synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] +synonym: "medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19] +synonym: "medium-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19] +synonym: "medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19] +synonym: "medium-chain hydrolase activity" EXACT [EC:3.1.2.19] +synonym: "myristoyl-CoA thioesterase activity" EXACT [EC:3.1.2.19] +xref: EC:3.1.2.19 +xref: MetaCyc:3.1.2.19-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047381 +name: dodecanoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +alt_id: GO:0016294 +def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN] +synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "dodecanoyl-ACP hydrolase activity" EXACT [] +synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] +synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] +synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21] +synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT [] +synonym: "lauroyl-ACP hydrolase activity" EXACT [] +synonym: "lauryl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21] +synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21] +synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21] +xref: EC:3.1.2.21 +xref: MetaCyc:3.1.2.21-RXN +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0047382 +name: methylphosphothioglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + S-methyl-3-phospho-1-thio-D-glycerate = phosphate + S-methyl-1-thio-D-glycerate." [EC:3.1.3.14, MetaCyc:3.1.3.14-RXN] +synonym: "methylthiophosphoglycerate phosphatase activity" EXACT [EC:3.1.3.14] +synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" EXACT [EC:3.1.3.14] +xref: EC:3.1.3.14 +xref: MetaCyc:3.1.3.14-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047383 +name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate = phosphate + 1-guanidino-1-deoxy-scyllo-inositol." [EC:3.1.3.40, MetaCyc:3.1.3.40-RXN] +synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" EXACT [EC:3.1.3.40] +synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.40] +synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" EXACT [EC:3.1.3.40] +xref: EC:3.1.3.40 +xref: MetaCyc:3.1.3.40-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047384 +name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" EXACT [EC:3.1.3.47] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.47] +synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47] +xref: EC:3.1.3.47 +xref: MetaCyc:3.1.3.47-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047385 +name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.52] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.52] +synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT [EC:3.1.3.52] +synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52] +synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52] +xref: EC:3.1.3.52 +xref: MetaCyc:3.1.3.52-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047386 +name: fructose-2,6-bisphosphate 6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + D-fructose 2,6-bisphosphate = phosphate + fructose-2-phosphate." [EC:3.1.3.54, MetaCyc:3.1.3.54-RXN] +synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] +synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] +synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" EXACT [EC:3.1.3.54] +synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54] +xref: EC:3.1.3.54 +xref: MetaCyc:3.1.3.54-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047387 +name: serine-ethanolaminephosphate phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + serine phosphoethanolamine = phosphoryl-ethanolamine + L-serine." [EC:3.1.4.13, MetaCyc:3.1.4.13-RXN] +subset: gosubset_prok +synonym: "SEP diesterase activity" EXACT [EC:3.1.4.13] +synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" EXACT [EC:3.1.4.13] +synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" EXACT [EC:3.1.4.13] +xref: EC:3.1.4.13 +xref: MetaCyc:3.1.4.13-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047388 +name: adenylyl-[glutamate-ammonia ligase] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + adenylyl-GS = glutaminesyn-oligomer + AMP." [EC:3.1.4.15, MetaCyc:3.1.4.15-RXN] +synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [EC:3.1.4.15] +synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [EC:3.1.4.15] +synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [EC:3.1.4.15] +synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [EC:3.1.4.15] +xref: EC:3.1.4.15 +xref: MetaCyc:3.1.4.15-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047389 +name: glycerophosphocholine phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN] +subset: gosubset_prok +synonym: "glycerolphosphorylcholine phosphodiesterase activity" EXACT [EC:3.1.4.2] +synonym: "glycerophosphinicocholine diesterase activity" EXACT [EC:3.1.4.2] +synonym: "glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] +synonym: "glycerylphosphorylcholinediesterase activity" EXACT [EC:3.1.4.2] +synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" EXACT [EC:3.1.4.2] +synonym: "sn-glycero-3-phosphorylcholine diesterase activity" EXACT [EC:3.1.4.2] +xref: EC:3.1.4.2 +xref: MetaCyc:3.1.4.2-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047390 +name: glycerophosphocholine cholinephosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = phosphoryl-choline + glycerol." [EC:3.1.4.38, MetaCyc:3.1.4.38-RXN] +synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] +synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38] +xref: EC:3.1.4.38 +xref: MetaCyc:3.1.4.38-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047391 +name: alkylglycerophosphoethanolamine phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanol-amine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN] +synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" EXACT [EC:3.1.4.39] +synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39] +xref: EC:3.1.4.39 +xref: MetaCyc:3.1.4.39-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047392 +name: CMP-N-acylneuraminate phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN] +synonym: "CMP-N-acetylneuraminate hydrolase activity" EXACT [EC:3.1.4.40] +synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" EXACT [EC:3.1.4.40] +synonym: "CMP-N-acylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] +synonym: "CMP-sialate hydrolase activity" EXACT [EC:3.1.4.40] +synonym: "CMP-sialic acid hydrolase activity" EXACT [EC:3.1.4.40] +synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40] +synonym: "cytidine monophosphosialate hydrolase activity" EXACT [EC:3.1.4.40] +synonym: "cytidine monophosphosialic hydrolase activity" EXACT [EC:3.1.4.40] +xref: EC:3.1.4.40 +xref: MetaCyc:3.1.4.40-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047393 +name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + glycerol 1,2-cyclic phosphate = glycerol-3-phosphate." [EC:3.1.4.42, MetaCyc:3.1.4.42-RXN] +synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" EXACT [EC:3.1.4.42] +synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" EXACT [EC:3.1.4.42] +xref: EC:3.1.4.42 +xref: MetaCyc:3.1.4.42-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047394 +name: glycerophosphoinositol inositolphosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN] +subset: gosubset_prok +synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT [] +synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] +synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] +synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] +synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] +synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43] +synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43] +xref: EC:3.1.4.43 +xref: MetaCyc:3.1.4.43-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047395 +name: glycerophosphoinositol glycerophosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + sn-glycero-3-phospho-1-inositol = glycerol-3-phosphate + inositol." [EC:3.1.4.44, MetaCyc:3.1.4.44-RXN] +synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] +synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] +synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44] +xref: EC:3.1.4.44 +xref: MetaCyc:3.1.4.44-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047396 +name: glycosylphosphatidylinositol diacylglycerol-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN] +subset: gosubset_prok +synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] +synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14] +synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" EXACT [EC:4.6.1.14] +synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" EXACT [EC:4.6.1.14] +synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14] +synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14] +synonym: "GPI-PLC activity" EXACT [EC:4.6.1.14] +synonym: "GPI-specific phospholipase C activity" EXACT [EC:4.6.1.14] +synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT [] +synonym: "VSG-lipase activity" EXACT [EC:4.6.1.14] +xref: EC:4.6.1.14 +xref: MetaCyc:3.1.4.47-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0047397 +name: dolichylphosphate-glucose phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN] +synonym: "Dol-P-Glc phosphodiesterase activity" EXACT [EC:3.1.4.48] +synonym: "dolichol phosphoglucose phosphodiesterase activity" EXACT [EC:3.1.4.48] +synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.48] +synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.48 +xref: MetaCyc:3.1.4.48-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047398 +name: dolichylphosphate-mannose phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN] +synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.49] +synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49] +xref: EC:3.1.4.49 +xref: MetaCyc:3.1.4.49-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047399 +name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN] +synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" EXACT [EC:3.1.4.51] +synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51] +xref: EC:3.1.4.51 +xref: MetaCyc:3.1.4.51-RXN +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047400 +name: phosphonoacetate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + phosphonoacetate = phosphate + acetate." [EC:3.11.1.2, MetaCyc:3.11.1.2-RXN] +synonym: "phosphonoacetate phosphonohydrolase activity" EXACT [EC:3.11.1.2] +xref: EC:3.11.1.2 +xref: MetaCyc:3.11.1.2-RXN +is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds + +[Term] +id: GO:0047401 +name: trithionate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + trithionate = 2 H+ + SO4(2-) (sulfate) + S2O3(2-)." [EC:3.12.1.1, MetaCyc:3.12.1.1-RXN] +synonym: "trithionate thiosulfohydrolase activity" EXACT [EC:3.12.1.1] +xref: EC:3.12.1.1 +xref: MetaCyc:3.12.1.1-RXN +is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds + +[Term] +id: GO:0047402 +name: protein-glucosylgalactosylhydroxylysine glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN] +synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" EXACT [EC:3.2.1.107] +synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107] +xref: EC:3.2.1.107 +xref: MetaCyc:3.2.1.107-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047403 +name: lacto-N-biosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN] +synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140] +xref: EC:3.2.1.140 +xref: MetaCyc:3.2.1.140-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047404 +name: glucuronosyl-disulfoglucosamine glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2-,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN] +synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] +synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56] +synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT [] +xref: EC:3.2.1.56 +xref: MetaCyc:3.2.1.56-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047405 +name: pyrimidine-5'-nucleotide nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN] +synonym: "Pyr5N activity" EXACT [EC:3.2.2.10] +synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10] +synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10] +xref: EC:3.2.2.10 +xref: MetaCyc:3.2.2.10-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047406 +name: beta-aspartyl-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-beta-aspartyl-N-acetyl-D-glucosaminylamine = L-asparagine + N-acetyl-D-glucosamine." [EC:3.2.2.11, MetaCyc:3.2.2.11-RXN] +synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" EXACT [EC:3.2.2.11] +synonym: "beta-aspartylacetylglucosaminidase activity" EXACT [EC:3.2.2.11] +xref: EC:3.2.2.11 +xref: MetaCyc:3.2.2.11-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047407 +name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN] +subset: gosubset_prok +synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.24] +synonym: "ADP-ribosyl glycohydrolase activity" EXACT [EC:3.2.2.24] +synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" EXACT [EC:3.2.2.24] +synonym: "azoferredoxin glycosidase activity" EXACT [EC:3.2.2.24] +synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24] +synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24] +synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24] +xref: EC:3.2.2.24 +xref: MetaCyc:3.2.2.24-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047408 +name: alkenylglycerophosphocholine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN] +synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" EXACT [EC:3.3.2.2] +synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2] +xref: EC:3.3.2.2 +xref: MetaCyc:3.3.2.2-RXN +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0047409 +name: alkenylglycerophosphoethanolamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN] +synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5] +xref: EC:3.3.2.5 +xref: MetaCyc:3.3.2.5-RXN +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0047410 +name: N-formylmethionylaminoacyl-tRNA deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [EC:3.5.1.27, MetaCyc:3.5.1.27-RXN] +synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [EC:3.5.1.27] +xref: EC:3.5.1.27 +xref: MetaCyc:3.5.1.27-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047411 +name: 2-(acetamidomethylene)succinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN] +synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.29] +synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.29] +xref: EC:3.5.1.29 +xref: MetaCyc:3.5.1.29-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047412 +name: N-(long-chain-acyl)ethanolamine deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanol-amine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN] +synonym: "acylethanolamine amidase activity" EXACT [] +synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT [] +synonym: "N-acylethanolamine amidohydrolase activity" EXACT [] +xref: EC:3.5.1.60 +xref: MetaCyc:3.5.1.60-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047413 +name: N(alpha)-benzyloxycarbonylleucine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N(alpha)-benzyloxycarbonyl-L-leucine = L-leucine + CO2 + benzyl alcohol." [EC:3.5.1.64, MetaCyc:3.5.1.64-RXN] +synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] +synonym: "benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] +synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64] +synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64] +synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64] +xref: EC:3.5.1.64 +xref: MetaCyc:3.5.1.64-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047414 +name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 2-(hydroxymethyl)-3-(acetamidomethylene)succinate = CO2 + NH3 + 2-(hydroxymethyl)-4-oxobutanoate + acetate." [EC:3.5.1.66, MetaCyc:3.5.1.66-RXN] +synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.66] +synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.66] +synonym: "compound B hydrolase activity" EXACT [EC:3.5.1.66] +xref: EC:3.5.1.66 +xref: MetaCyc:3.5.1.66-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047415 +name: D-benzoylarginine-4-nitroanilide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-benzoyl-D-arginine-4-nitroanilide = N-benzoyl-D-arginine + 4-nitroaniline." [EC:3.5.1.72, MetaCyc:3.5.1.72-RXN] +synonym: "benzoyl-D-arginine arylamidase activity" EXACT [EC:3.5.1.72] +synonym: "D-BAPA-ase activity" EXACT [EC:3.5.1.72] +synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" EXACT [EC:3.5.1.72] +xref: EC:3.5.1.72 +xref: MetaCyc:3.5.1.72-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047416 +name: arylalkyl acylamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN] +subset: gosubset_prok +synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76] +synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76] +xref: EC:3.5.1.76 +xref: MetaCyc:3.5.1.76-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047417 +name: N-carbamoyl-D-amino acid hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN] +subset: gosubset_prok +synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77] +xref: EC:3.5.1.77 +xref: MetaCyc:3.5.1.77-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047418 +name: phthalyl amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN] +synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79] +synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79] +xref: EC:3.5.1.79 +xref: MetaCyc:3.5.1.79-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047419 +name: N-acetylgalactosamine-6-phosphate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.-, MetaCyc:3.5.1.80-RXN] +xref: EC:3.5.1.- +xref: MetaCyc:3.5.1.80-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047420 +name: N-acyl-D-amino-acid deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN] +subset: gosubset_prok +synonym: "D-aminoacylase activity" EXACT [EC:3.5.1.81] +synonym: "N-acyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.81] +xref: EC:3.5.1.81 +xref: MetaCyc:3.5.1.81-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047421 +name: N-acyl-D-glutamate deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acyl-D-glutamate = D-glutamate + carboxylate." [EC:3.5.1.82, MetaCyc:3.5.1.82-RXN] +subset: gosubset_prok +synonym: "N-acyl-D-glutamate amidohydrolase activity" EXACT [EC:3.5.1.82] +xref: EC:3.5.1.82 +xref: MetaCyc:3.5.1.82-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047422 +name: N-acyl-D-aspartate deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acyl-D-aspartate = D-aspartate + carboxylate." [EC:3.5.1.83, MetaCyc:3.5.1.83-RXN] +subset: gosubset_prok +synonym: "N-acyl-D-aspartate amidohydrolase activity" EXACT [EC:3.5.1.83] +xref: EC:3.5.1.83 +xref: MetaCyc:3.5.1.83-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047423 +name: N-methylhydantoinase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + N-methylhydantoin + ATP = phosphate + N-carbamoylsarcosine + ADP." [EC:3.5.2.14, MetaCyc:3.5.2.14-RXN] +subset: gosubset_prok +synonym: "methylhydantoin amidase activity" EXACT [EC:3.5.2.14] +synonym: "N-methylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.14] +synonym: "N-methylhydantoin hydrolase activity" EXACT [EC:3.5.2.14] +synonym: "N-methylhydantoinase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] +synonym: "N-methylhydantoinase activity" EXACT [EC:3.5.2.14] +synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.14] +xref: EC:3.5.2.14 +xref: MetaCyc:3.5.2.14-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047424 +name: methylenediurea deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + NH(2)-CO-NH-CH(2)-NH-CO-NH(2) = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN] +subset: gosubset_prok +synonym: "methylenediurea aminohydrolase activity" EXACT [EC:3.5.3.21] +synonym: "methylenediurease activity" EXACT [EC:3.5.3.21] +xref: EC:3.5.3.21 +xref: MetaCyc:3.5.3.21-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047425 +name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-pyrroline-4-hydroxy-2-carboxylate = NH3 + 2,5-dioxopentanoate." [EC:3.5.4.22, MetaCyc:3.5.4.22-RXN] +synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" EXACT [EC:3.5.4.22] +synonym: "HPC deaminase activity" EXACT [EC:3.5.4.22] +xref: EC:3.5.4.22 +xref: MetaCyc:3.5.4.22-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047426 +name: ricinine nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN] +synonym: "ricinine aminohydrolase activity" EXACT [EC:3.5.5.2] +xref: EC:3.5.5.2 +xref: MetaCyc:3.5.5.2-RXN +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0047427 +name: cyanoalanine nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 3-cyano-L-alanine = NH3 + L-aspartate." [EC:3.5.5.4, MetaCyc:3.5.5.4-RXN] +synonym: "3-cyano-L-alanine aminohydrolase activity" EXACT [EC:3.5.5.4] +synonym: "beta-cyanoalanine nitrilase activity" EXACT [EC:3.5.5.4] +xref: EC:3.5.5.4 +xref: MetaCyc:3.5.5.4-RXN +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0047428 +name: arylacetonitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN] +synonym: "arylacetonitrile aminohydrolase activity" EXACT [EC:3.5.5.5] +xref: EC:3.5.5.5 +xref: MetaCyc:3.5.5.5-RXN +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0047429 +name: nucleoside-triphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide." [EC:3.6.1.19, MetaCyc:3.6.1.19-RXN] +subset: gosubset_prok +synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.19] +synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT [] +xref: EC:3.6.1.19 +xref: MetaCyc:3.6.1.19-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047430 +name: oligosaccharide-diphosphodolichol diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN] +synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EXACT [EC:3.6.1.44] +synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT [] +xref: EC:3.6.1.44 +xref: MetaCyc:3.6.1.44-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047431 +name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate = CO2 + 3-hydroxy-2-methylpyridine-5-carboxylate." [EC:4.1.1.51, MetaCyc:4.1.1.51-RXN] +synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" EXACT [EC:4.1.1.51] +synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" EXACT [EC:4.1.1.51] +xref: EC:4.1.1.51 +xref: MetaCyc:4.1.1.51-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047432 +name: 2,2-dialkylglycine decarboxylase (pyruvate) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2-dialkylglycine + pyruvate = dialkyl ketone + L-alanine + CO2." [EC:4.1.1.64, MetaCyc:4.1.1.64-RXN] +subset: gosubset_prok +synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" EXACT [EC:4.1.1.64] +synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" EXACT [EC:4.1.1.64] +synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" EXACT [EC:4.1.1.64] +synonym: "alpha-dialkyl amino acid transaminase activity" EXACT [EC:4.1.1.64] +synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" EXACT [EC:4.1.1.64] +synonym: "dialkylamino-acid decarboxylase (pyruvate)" EXACT [EC:4.1.1.64] +synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" EXACT [EC:4.1.1.64] +xref: EC:4.1.1.64 +xref: MetaCyc:4.1.1.64-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047433 +name: branched-chain-2-oxoacid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2." [EC:4.1.1.72, MetaCyc:4.1.1.72-RXN] +synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" EXACT [EC:4.1.1.72] +synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.72] +synonym: "BCKA" RELATED [EC:4.1.1.72] +synonym: "branched-chain alpha-keto acid decarboxylase activity" EXACT [EC:4.1.1.72] +synonym: "branched-chain keto acid decarboxylase activity" EXACT [EC:4.1.1.72] +synonym: "branched-chain oxo acid decarboxylase activity" EXACT [EC:4.1.1.72] +xref: EC:4.1.1.72 +xref: MetaCyc:4.1.1.72-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047434 +name: indolepyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN] +subset: gosubset_prok +synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74] +synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] +synonym: "indol-3-yl-pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74] +synonym: "indole-3-pyruvate decarboxylase activity" EXACT [EC:4.1.1.74] +xref: EC:4.1.1.74 +xref: MetaCyc:4.1.1.74-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047435 +name: 5-guanidino-2-oxopentanoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-guanidino-2-oxo-pentanoate = CO2 + 4-guanidinobutanoate." [EC:4.1.1.75, MetaCyc:4.1.1.75-RXN] +synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" EXACT [EC:4.1.1.75] +synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.75] +synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" EXACT [EC:4.1.1.75] +synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] +synonym: "alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75] +xref: EC:4.1.1.75 +xref: MetaCyc:4.1.1.75-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047436 +name: arylmalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aryl-2-methylmalonate = CO2 + 2-arylpropionate." [EC:4.1.1.76, MetaCyc:4.1.1.76-RXN] +subset: gosubset_prok +synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" EXACT [EC:4.1.1.76] +synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" EXACT [EC:4.1.1.76] +synonym: "AMDASE" RELATED [EC:4.1.1.76] +synonym: "AMDase activity" EXACT [EC:4.1.1.76] +xref: EC:4.1.1.76 +xref: MetaCyc:4.1.1.76-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047437 +name: 4-oxalocrotonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN] +subset: gosubset_prok +synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.1.1.77] +synonym: "4-oxalocrotonate carboxy-lyase activity" EXACT [EC:4.1.1.77] +xref: EC:4.1.1.77 +xref: MetaCyc:4.1.1.77-RXN +xref: UM-BBD_enzymeID:e0905 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047438 +name: 2-dehydro-3-deoxy-L-pentonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN] +synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.18] +synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.18] +synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" EXACT [EC:4.1.2.18] +synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18] +synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" EXACT [EC:4.1.2.18] +synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18] +xref: EC:4.1.2.18 +xref: MetaCyc:4.1.2.18-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047439 +name: 3-deoxy-D-manno-octulosonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, MetaCyc:4.1.2.23-RXN] +synonym: "2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:4.1.2.23] +synonym: "2-keto-3-deoxyoctonic aldolase activity" EXACT [EC:4.1.2.23] +synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" EXACT [EC:4.1.2.23] +synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" EXACT [EC:4.1.2.23] +synonym: "3-deoxy-D-manno-octulosonic aldolase activity" EXACT [EC:4.1.2.23] +synonym: "3-deoxyoctulosonic aldolase activity" EXACT [EC:4.1.2.23] +synonym: "KDOaldolase activity" EXACT [EC:4.1.2.23] +xref: EC:4.1.2.23 +xref: MetaCyc:4.1.2.23-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047440 +name: 2-dehydro-3-deoxy-D-pentonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, MetaCyc:4.1.2.28-RXN] +synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.28] +synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" EXACT [EC:4.1.2.28] +synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28] +xref: EC:4.1.2.28 +xref: MetaCyc:4.1.2.28-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047441 +name: 5-dehydro-2-deoxyphosphogluconate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-dehydro-2-deoxy-D-gluconate 6-phosphate = malonate semialdehyde + dihydroxy-acetone-phosphate." [EC:4.1.2.29, MetaCyc:4.1.2.29-RXN] +synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.29] +synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" EXACT [EC:4.1.2.29] +synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] +synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29] +xref: EC:4.1.2.29 +xref: MetaCyc:4.1.2.29-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047442 +name: 17-alpha-hydroxyprogesterone aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN] +synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] +synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" EXACT [EC:4.1.2.30] +synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30] +synonym: "17alpha-hydroxyprogesterone aldolase activity" EXACT [EC:4.1.2.30] +synonym: "C-17/C-20 lyase activity" EXACT [EC:4.1.2.30] +xref: EC:4.1.2.30 +xref: MetaCyc:4.1.2.30-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047443 +name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN] +subset: gosubset_prok +synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.17] +synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.17] +synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" EXACT [EC:4.1.3.17] +synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" EXACT [EC:4.1.3.17] +synonym: "pyruvate aldolase activity" EXACT [EC:4.1.3.17] +xref: EC:4.1.3.17 +xref: MetaCyc:4.1.3.17-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047444 +name: N-acylneuraminate-9-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN] +synonym: "N-acetylneuraminate 9-phosphate lyase activity" EXACT [EC:2.5.1.57] +synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" EXACT [EC:2.5.1.57] +synonym: "N-acetylneuraminate 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] +synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.57] +synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" EXACT [EC:2.5.1.57] +synonym: "sialic acid 9-phosphate synthetase activity" EXACT [EC:2.5.1.57] +xref: EC:2.5.1.57 +xref: MetaCyc:4.1.3.20-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047445 +name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = acetate + 7-methyl-3-oxooctanoyl-CoA." [EC:4.1.3.26, MetaCyc:4.1.3.26-RXN] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" EXACT [EC:4.1.3.26] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" EXACT [EC:4.1.3.26] +synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.26] +synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" EXACT [EC:4.1.3.26] +synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" EXACT [EC:4.1.3.26] +synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" EXACT [EC:4.1.3.26] +xref: EC:4.1.3.26 +xref: MetaCyc:4.1.3.26-RXN +xref: UM-BBD_enzymeID:e0723 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047446 +name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA." [EC:4.1.3.35, MetaCyc:4.1.3.35-RXN] +synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.35] +synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" EXACT [EC:4.1.3.35] +xref: EC:4.1.3.35 +xref: MetaCyc:4.1.3.35-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047447 +name: erythro-3-hydroxyaspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN] +synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" EXACT [EC:4.3.1.20] +synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT [] +synonym: "erythro-beta-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.20] +xref: EC:4.3.1.20 +xref: MetaCyc:4.3.1.20-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047448 +name: 5-dehydro-4-deoxyglucarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-keto-4-deoxy-D-glucarate = CO2 + H2O + 2,5-dioxopentanoate." [EC:4.2.1.41, MetaCyc:4.2.1.41-RXN] +subset: gosubset_prok +synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.41] +synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.41] +synonym: "5-keto-4-deoxy-glucarate dehydratase activity" EXACT [EC:4.2.1.41] +synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" EXACT [EC:4.2.1.41] +synonym: "deoxyketoglucarate dehydratase activity" EXACT [EC:4.2.1.41] +xref: EC:4.2.1.41 +xref: MetaCyc:4.2.1.41-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047449 +name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = H2O + 2,5-dioxopentanoate." [EC:4.2.1.43, MetaCyc:4.2.1.43-RXN] +synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.43] +synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.43] +synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" EXACT [EC:4.2.1.43] +xref: EC:4.2.1.43 +xref: MetaCyc:4.2.1.43-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047450 +name: crotonoyl-[acyl-carrier-protein] hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN] +synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.58] +synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.58] +synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.58] +synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.58] +synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [EC:4.2.1.58] +synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.58] +synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [] +synonym: "crotonoyl-ACP hydratase activity" EXACT [] +synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT [EC:4.2.1.58] +synonym: "crotonyl acyl carrier protein hydratase activity" EXACT [EC:4.2.1.58] +synonym: "enoyl acyl carrier protein hydrase activity" EXACT [EC:4.2.1.58] +xref: EC:4.2.1.58 +xref: MetaCyc:4.2.1.58-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047451 +name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN] +synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59] +synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59] +synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59] +synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT [] +synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59] +synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" EXACT [EC:4.2.1.59] +synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" EXACT [EC:4.2.1.59] +synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59] +synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" EXACT [EC:4.2.1.59] +synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59] +xref: EC:4.2.1.59 +xref: MetaCyc:4.2.1.59-RXN +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0047452 +name: protoaphin-aglucone dehydratase (cyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin." [EC:4.2.1.73, MetaCyc:4.2.1.73-RXN] +synonym: "protoaphin dehydratase (cyclizing)" EXACT [EC:4.2.1.73] +synonym: "protoaphin dehydratase activity" EXACT [EC:4.2.1.73] +synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" EXACT [EC:4.2.1.73] +synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" EXACT [EC:4.2.1.73] +xref: EC:4.2.1.73 +xref: MetaCyc:4.2.1.73-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047453 +name: ATP-dependent NAD(P)H-hydrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide + ATP = phosphate + NADH + ADP." [EC:4.2.1.93, MetaCyc:4.2.1.93-RXN] +synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" EXACT [EC:4.2.1.93] +synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93] +synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] +synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" EXACT [EC:4.2.1.93] +xref: EC:4.2.1.93 +xref: MetaCyc:4.2.1.93-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047454 +name: phaseollidin hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin." [EC:4.2.1.97, MetaCyc:4.2.1.97-RXN] +synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" EXACT [EC:4.2.1.97] +synonym: "phaseollidin-hydrate hydro-lyase activity" EXACT [EC:4.2.1.97] +xref: EC:4.2.1.97 +xref: MetaCyc:4.2.1.97-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047455 +name: 16-alpha-hydroxyprogesterone dehydratase activity +namespace: molecular_function +alt_id: GO:0047523 +def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN] +synonym: "16-alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] +synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] +synonym: "16-dehydroprogesterone hydratase activity" RELATED [] +synonym: "16alpha-dehydroxylase activity" EXACT [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone dehydratase activity" EXACT [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" EXACT [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" EXACT [EC:4.2.1.98] +synonym: "hydroxyprogesterone dehydroxylase activity" EXACT [] +xref: EC:4.2.1.98 +xref: MetaCyc:4.2.1.98-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047456 +name: 2-methylisocitrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylisocitrate = H2O + 2-methylaconitate." [EC:4.2.1.99, MetaCyc:4.2.1.99-RXN] +subset: gosubset_prok +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99] +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.99] +xref: EC:4.2.1.99 +xref: MetaCyc:4.2.1.99-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047457 +name: exo-(1,4)-alpha-D-glucan lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: linear alpha-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN] +synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" EXACT [EC:4.2.2.13] +synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] +synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13] +synonym: "alpha-1,4-glucan exo-lyase activity" EXACT [EC:4.2.2.13] +synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13] +synonym: "exo-(1->4)-alpha-D-glucan lyase activity" EXACT [EC:4.2.2.13] +synonym: "exo-alpha-1,4-glucan lyase activity" EXACT [EC:4.2.2.13] +xref: EC:4.2.2.13 +xref: MetaCyc:4.2.2.13-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047458 +name: beta-pyrazolylalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrazole + O-acetyl-L-serine = acetate + 3-(pyrazol-1-yl)-L-alanine." [EC:2.5.1.51, MetaCyc:4.2.99.14-RXN] +synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] +synonym: "beta-(1-pyrazolyl)alanine synthase activity" EXACT [EC:2.5.1.51] +synonym: "beta-pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] +synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT [] +synonym: "BPA-synthase activity" EXACT [EC:2.5.1.51] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" EXACT [EC:2.5.1.51] +synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" EXACT [EC:2.5.1.51] +synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51] +synonym: "pyrazolealanine synthase activity" EXACT [EC:2.5.1.51] +synonym: "pyrazolylalaninase activity" EXACT [EC:2.5.1.51] +xref: EC:2.5.1.51 +xref: MetaCyc:4.2.99.14-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047459 +name: 3-aminobutyryl-CoA ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-3-aminobutyryl-CoA = NH3 + crotonyl-CoA." [EC:4.3.1.14, MetaCyc:4.3.1.14-RXN] +synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.3.1.14] +synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" EXACT [EC:4.3.1.14] +synonym: "L-3-aminobutyryl-CoA deaminase activity" EXACT [EC:4.3.1.14] +xref: EC:4.3.1.14 +xref: MetaCyc:4.3.1.14-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047460 +name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-2-amino-4-chloropent-4-enoate = NH3 + HCl + 2-oxopent-4-enoate." [EC:4.5.1.4, MetaCyc:4.5.1.4-RXN] +synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" EXACT [EC:4.5.1.4] +synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" EXACT [EC:4.5.1.4] +synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" EXACT [EC:4.5.1.4] +xref: EC:4.5.1.4 +xref: MetaCyc:4.5.1.4-RXN +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0047461 +name: (+)-delta-cadinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = pyrophosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" EXACT [EC:4.2.3.13] +synonym: "D-cadinene synthase activity" EXACT [EC:4.2.3.13] +xref: EC:4.2.3.13 +xref: MetaCyc:4.6.1.11-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0047462 +name: phenylalanine racemase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-phenylalanine + ATP = D-phenylalanine + pyrophosphate + AMP." [EC:5.1.1.11, MetaCyc:5.1.1.11-RXN] +subset: gosubset_prok +synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11] +synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" EXACT [EC:5.1.1.11] +synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11] +synonym: "phenylalanine racemase activity" EXACT [EC:5.1.1.11] +xref: EC:5.1.1.11 +xref: MetaCyc:5.1.1.11-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047463 +name: 2-aminohexano-6-lactam racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-amino-hexano-6-lactam = D-2-amino-hexano-6-lactam." [EC:5.1.1.15, MetaCyc:5.1.1.15-RXN] +synonym: "2-amino-hexano-6-lactam racemase activity" EXACT [EC:5.1.1.15] +synonym: "alpha-amino-epsilon-caprolactam racemase activity" EXACT [EC:5.1.1.15] +xref: EC:5.1.1.15 +xref: MetaCyc:5.1.1.15-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047464 +name: heparosan-N-sulfate-glucuronate 5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] +synonym: "C-5 uronosyl epimerase activity" EXACT [EC:5.1.3.17] +synonym: "D-glucuronyl C-5 epimerase activity" EXACT [EC:5.1.3.17] +synonym: "heparosan epimerase activity" EXACT [EC:5.1.3.17] +synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.17] +synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT [] +synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" EXACT [EC:5.1.3.17] +synonym: "polyglucuronate epimerase activity" EXACT [EC:5.1.3.17] +xref: EC:5.1.3.17 +xref: MetaCyc:5.1.3.17-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047465 +name: N-acylglucosamine-6-phosphate 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN] +subset: gosubset_prok +synonym: "acylglucosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] +synonym: "acylglucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] +synonym: "acylmannosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] +synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] +synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] +synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9] +xref: EC:5.1.3.9 +xref: MetaCyc:5.1.3.9-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047466 +name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity +namespace: molecular_function +alt_id: GO:0018840 +def: "Catalysis of the reaction: cis-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide." [EC:5.2.1.10, MetaCyc:5.2.1.10-RXN] +synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" EXACT [EC:5.2.1.10] +synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" EXACT [EC:5.2.1.-] +synonym: "chlorodienelactone isomerase activity" EXACT [EC:5.2.1.-] +xref: EC:5.2.1.- +xref: EC:5.2.1.10 +xref: MetaCyc:5.2.1.10-RXN +xref: UM-BBD_enzymeID:e0232 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047467 +name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN] +xref: MetaCyc:5.2.1.11-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047468 +name: phosphoglucomutase (glucose-cofactor) activity +namespace: molecular_function +def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN] +synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" EXACT [EC:5.4.2.5] +synonym: "glucose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.5] +xref: EC:5.4.2.5 +xref: MetaCyc:5.4.2.5-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0047469 +name: 4-carboxymethyl-4-methylbutenolide mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, MetaCyc:5.4.99.14-RXN] +synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" EXACT [EC:5.4.99.14] +synonym: "4-methyl-2-enelactone isomerase activity" EXACT [EC:5.4.99.14] +synonym: "4-methyl-2-enelactone methyl-isomerase activity" EXACT [EC:5.4.99.14] +synonym: "4-methyl-3-enelactone methyl isomerase activity" EXACT [EC:5.4.99.14] +synonym: "4-methylmuconolactone methylisomerase activity" EXACT [EC:5.4.99.14] +xref: EC:5.4.99.14 +xref: MetaCyc:5.4.99.14-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047470 +name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(1,4-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-(1,4-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN] +subset: gosubset_prok +synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15] +synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15] +synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15] +xref: EC:5.4.99.15 +xref: MetaCyc:5.4.99.15-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047471 +name: maltose alpha-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN] +subset: gosubset_prok +synonym: "maltose alpha-D-glucosylmutase activity" EXACT [EC:5.4.99.16] +synonym: "maltose glucosylmutase activity" EXACT [EC:5.4.99.16] +synonym: "trehalose synthase activity" EXACT [EC:5.4.99.16] +xref: EC:5.4.99.16 +xref: MetaCyc:5.4.99.16-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047472 +name: 3-carboxy-cis,cis-muconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.2, MetaCyc:5.5.1.2-RXN] +subset: gosubset_prok +synonym: "2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.2] +synonym: "3-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] +synonym: "3-carboxymuconolactone hydrolase activity" EXACT [EC:5.5.1.2] +synonym: "beta-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2] +synonym: "CMLE activity" EXACT [EC:5.5.1.2] +xref: EC:5.5.1.2 +xref: MetaCyc:5.5.1.2-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047473 +name: D-alanine-poly(phosphoribitol) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(ribitol phosphate) + D-alanine + ATP = O-D-alanyl-poly(ribitol phosphate) + pyrophosphate + AMP." [EC:6.1.1.13, MetaCyc:6.1.1.13-RXN] +subset: gosubset_prok +synonym: "D-alanine-activating enzyme activity" RELATED [EC:6.1.1.13] +synonym: "D-alanine-D-alanyl carrier protein ligase activity" EXACT [EC:6.1.1.13] +synonym: "D-alanine-membrane acceptor ligase activity" EXACT [EC:6.1.1.13] +synonym: "D-alanine: membrane acceptor ligase activity" EXACT [EC:6.1.1.13] +synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" EXACT [EC:6.1.1.13] +synonym: "D-alanyl-poly(phosphoribitol) synthetase activity" EXACT [EC:6.1.1.13] +xref: EC:6.1.1.13 +xref: MetaCyc:6.1.1.13-RXN +is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds + +[Term] +id: GO:0047474 +name: long-chain-fatty-acid-luciferin-component ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + pyrophosphate + AMP." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN] +subset: gosubset_prok +synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19] +synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19] +xref: EC:6.2.1.19 +xref: MetaCyc:6.2.1.19-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047475 +name: phenylacetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + phenylacetate + ATP = phenylacetyl-CoA + products of ATP breakdown." [EC:6.2.1.30, MetaCyc:6.2.1.21-RXN] +subset: gosubset_prok +synonym: "PA-CoA ligase activity" EXACT [EC:6.2.1.30] +synonym: "phenacyl coenzyme A synthetase activity" EXACT [EC:6.2.1.30] +synonym: "phenylacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] +synonym: "phenylacetyl-CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30] +synonym: "phenylacetyl-CoA ligase activity" EXACT [EC:6.2.1.30] +xref: EC:6.2.1.30 +xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047476 +name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + pyrophosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN] +synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.28] +synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.28] +synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.28] +synonym: "DHCA-CoA ligase activity" EXACT [EC:6.2.1.28] +xref: EC:6.2.1.28 +xref: MetaCyc:6.2.1.28-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047478 +name: aspartate-ammonia ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + L-aspartate + ATP = phosphate + L-asparagine + ADP." [EC:6.3.1.4, MetaCyc:6.3.1.4-RXN] +synonym: "asparagine synthetase (adenosine diphosphate-forming)" EXACT [EC:6.3.1.4] +synonym: "asparagine synthetase (ADP-forming) activity" EXACT [EC:6.3.1.4] +synonym: "L-aspartate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.4] +xref: EC:6.3.1.4 +xref: MetaCyc:6.3.1.4-RXN +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047479 +name: trypanothione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN] +synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" EXACT [EC:6.3.1.9] +synonym: "TSR synthetase activity" EXACT [EC:6.3.1.9] +xref: EC:6.3.1.9 +xref: MetaCyc:6.3.1.9-RXN +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047480 +name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN] +comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766). +subset: gosubset_prok +synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-MurNAc-pentapeptide synthetase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [] +synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT [] +synonym: "UDPacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] +synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10] +xref: EC:6.3.2.10 +xref: MetaCyc:6.3.2.10-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047481 +name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN] +synonym: "D-alanine-membrane acceptor-ligase activity" EXACT [EC:6.3.2.16] +synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" EXACT [EC:6.3.2.16] +synonym: "D-alanine:membrane-acceptor ligase activity" EXACT [EC:6.3.2.16] +synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" EXACT [EC:6.3.2.16] +synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] +synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16] +xref: EC:6.3.2.16 +xref: MetaCyc:6.3.2.16-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047482 +name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine + ATP = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ADP." [EC:6.3.2.7, MetaCyc:6.3.2.7-RXN] +subset: gosubset_prok +synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7] +synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.7] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" EXACT [EC:6.3.2.7] +synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" EXACT [EC:6.3.2.7] +synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" EXACT [EC:6.3.2.7] +xref: EC:6.3.2.7 +xref: MetaCyc:6.3.2.7-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047483 +name: imidazoleacetate-phosphoribosyldiphosphate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phosphoribosyl diphosphate + imidazole-4-acetate + ATP = phosphate + pyrophosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + ADP." [EC:6.3.4.8, MetaCyc:6.3.4.8-RXN] +synonym: "5-phosphoribosylimidazoleacetate synthetase activity" EXACT [EC:6.3.4.8] +synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" EXACT [EC:6.3.4.8] +xref: EC:6.3.4.8 +xref: MetaCyc:6.3.4.8-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0047484 +name: regulation of response to osmotic stress +namespace: biological_process +def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0047485 +name: protein N-terminus binding +namespace: molecular_function +def: "Interacting selectively with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "N-terminal binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0047486 +name: chondroitin ABC lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.4] +subset: gosubset_prok +xref: EC:4.2.2.4 +xref: MetaCyc:4.2.2.4-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047487 +name: oligogalacturonide lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(4-deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate = 25-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN] +subset: gosubset_prok +synonym: "OGTE" RELATED [EC:4.2.2.6] +synonym: "oligogalacturonate lyase activity" EXACT [EC:4.2.2.6] +synonym: "unsaturated oligogalacturonate transeliminase activity" EXACT [EC:4.2.2.6] +xref: EC:4.2.2.6 +xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047488 +name: heparin lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN] +subset: gosubset_prok +synonym: "heparan sulfate lyase activity" RELATED [] +synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7] +synonym: "heparinase activity" EXACT [EC:4.2.2.7] +xref: EC:4.2.2.7 +xref: MetaCyc:4.2.2.7-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047489 +name: pectate disaccharide-lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of 4-(4-deoxy-a-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9] +subset: gosubset_prok +synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" EXACT [EC:4.2.2.9] +synonym: "exo-PATE" RELATED [EC:4.2.2.9] +synonym: "Exo-PATE activity" EXACT [EC:4.2.2.9] +synonym: "exo-PGL" RELATED [EC:4.2.2.9] +synonym: "Exo-PGL activity" EXACT [EC:4.2.2.9] +synonym: "exopectate lyase activity" EXACT [EC:4.2.2.9] +synonym: "exopectic acid transeliminase activity" EXACT [EC:4.2.2.9] +synonym: "exopolygalacturonate lyase activity" EXACT [EC:4.2.2.9] +synonym: "exopolygalacturonic acid-trans-eliminase activity" EXACT [EC:4.2.2.9] +synonym: "PATE activity" EXACT [EC:4.2.2.9] +synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9] +xref: EC:4.2.2.9 +xref: MetaCyc:4.2.2.9-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047490 +name: pectin lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of (14)-a-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-a-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10] +subset: gosubset_prok +synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.10] +synonym: "endo-pectin lyase activity" EXACT [EC:4.2.2.10] +synonym: "pectin methyltranseliminase activity" EXACT [EC:4.2.2.10] +synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10] +synonym: "pectolyase activity" EXACT [EC:4.2.2.10] +synonym: "PL activity" EXACT [EC:4.2.2.10] +synonym: "PMGL activity" EXACT [EC:4.2.2.10] +synonym: "PNL activity" EXACT [EC:4.2.2.10] +synonym: "polymethylgalacturonic transeliminase activity" EXACT [EC:4.2.2.10] +xref: EC:4.2.2.10 +xref: MetaCyc:4.2.2.10-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047491 +name: poly(alpha-L-guluronate) lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11] +subset: gosubset_prok +synonym: "alginase II activity" RELATED [EC:4.2.2.11] +synonym: "guluronate lyase activity" EXACT [EC:4.2.2.11] +synonym: "L-guluronan lyase activity" EXACT [EC:4.2.2.11] +synonym: "L-guluronate lyase activity" EXACT [EC:4.2.2.11] +synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" EXACT [EC:4.2.2.11] +synonym: "poly-alpha-L-guluronate lyase activity" EXACT [EC:4.2.2.11] +synonym: "polyguluronate-specific alginate lyase activity" EXACT [EC:4.2.2.11] +xref: EC:4.2.2.11 +xref: MetaCyc:4.2.2.11-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047492 +name: xanthan lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of the terminal b-D-mannosyl-b-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-a-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12] +xref: EC:4.2.2.12 +xref: MetaCyc:4.2.2.12-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047493 +name: ceramide cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-choline + N-acylsphingosine = CMP + sphingomyelin." [EC:2.7.8.3] +subset: gosubset_prok +synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.3] +synonym: "phosphorylcholine-ceramide transferase activity" EXACT [EC:2.7.8.3] +xref: EC:2.7.8.3 +xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047494 +name: serine-phosphoethanolamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-ethanolamine + L-serine = CMP + L-serine-phosphoethanolamine." [EC:2.7.8.4] +synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" EXACT [EC:2.7.8.4] +synonym: "serine ethanolamine phosphate synthetase activity" EXACT [EC:2.7.8.4] +synonym: "serine ethanolamine phosphodiester synthase activity" EXACT [EC:2.7.8.4] +synonym: "serine ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.4] +synonym: "serine-phosphinico-ethanolamine synthase activity" EXACT [EC:2.7.8.4] +synonym: "serinephosphoethanolamine synthase activity" EXACT [EC:2.7.8.4] +xref: EC:2.7.8.4 +xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047495 +name: membrane-oligosaccharide glycerophosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21] +synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.21] +synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21] +synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21] +xref: EC:2.7.8.21 +xref: MetaCyc:2.7.8.21-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047496 +name: vesicle transport along microtubule +namespace: biological_process +def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins." [GOC:ecd] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0047497 +name: mitochondrion transport along microtubule +namespace: biological_process +def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] +synonym: "mitochondrial migration along microtubule" EXACT [] +synonym: "mitochondrial transport along microtubule" EXACT [] +is_a: GO:0007018 ! microtubule-based movement +is_a: GO:0034643 ! mitochondrion localization, microtubule-mediated + +[Term] +id: GO:0047498 +name: calcium-dependent phospholipase A2 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; requires Ca2+." [EC:3.1.1.4] +synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW [] +synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW [] +is_a: GO:0004623 ! phospholipase A2 activity + +[Term] +id: GO:0047499 +name: calcium-independent phospholipase A2 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; does not require Ca2+." [EC:3.1.1.4] +synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW [] +is_a: GO:0004623 ! phospholipase A2 activity + +[Term] +id: GO:0047500 +name: (+)-borneol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-borneol + NAD+ = (+)-camphor + NADH + H+." [EC:1.1.1.198, MetaCyc:(+)-BORNEOL-DEHYDROGENASE-RXN] +synonym: "(+)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.198] +synonym: "bicyclic monoterpenol dehydrogenase activity" EXACT [EC:1.1.1.198] +xref: EC:1.1.1.198 +xref: MetaCyc:(+)-BORNEOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047501 +name: (+)-neomenthol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-neomenthol + NADP+ = (-)-menthone + NADPH + H+." [EC:1.1.1.208, MetaCyc:(+)-NEOMENTHOL-DEHYDROGENASE-RXN] +synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.208] +synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208] +xref: EC:1.1.1.208 +xref: MetaCyc:(+)-NEOMENTHOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047502 +name: (+)-sabinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (+)-sabinone + NADH + H+." [EC:1.1.1.228, MetaCyc:(+)-SABINOL-DEHYDROGENASE-RXN] +synonym: "(+)-cis-sabinol dehydrogenase activity" EXACT [EC:1.1.1.228] +synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.228] +xref: EC:1.1.1.228 +xref: MetaCyc:(+)-SABINOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047503 +name: (-)-borneol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-borneol + NAD+ = (-)-camphor + NADH + H+." [EC:1.1.1.227, MetaCyc:(-)-BORNEOL-DEHYDROGENASE-RXN] +synonym: "(-)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.227] +xref: EC:1.1.1.227 +xref: MetaCyc:(-)-BORNEOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047504 +name: (-)-menthol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthol + NADP+ = (-)-menthone + NADPH + H+." [EC:1.1.1.207, MetaCyc:(-)-MENTHOL-DEHYDROGENASE-RXN] +synonym: "(-)-menthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.207] +synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207] +xref: EC:1.1.1.207 +xref: MetaCyc:(-)-MENTHOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0741 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047505 +name: (-)-menthol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthol + NADPH + H+ + O2 = p-menthane-3,8-diol + NADP+ + H2O." [EC:1.14.13.46, MetaCyc:(-)-MENTHOL-MONOOXYGENASE-RXN] +synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.46] +synonym: "l-menthol monooxygenase activity" EXACT [EC:1.14.13.46] +xref: EC:1.14.13.46 +xref: MetaCyc:(-)-MENTHOL-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047506 +name: (deoxy)adenylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:(DEOXY)ADENYLATE-KINASE-RXN] +synonym: "ATP:(d)AMP phosphotransferase activity" EXACT [EC:2.7.4.11] +xref: EC:2.7.4.11 +xref: MetaCyc:(DEOXY)ADENYLATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047507 +name: (deoxy)nucleoside-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:(DEOXY)NUCLEOSIDE-PHOSPHATE-KINASE-RXN] +synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.13] +synonym: "deoxynucleoside monophosphate kinase activity" EXACT [EC:2.7.4.13] +synonym: "deoxynucleoside-5'-monophosphate kinase activity" EXACT [EC:2.7.4.13] +synonym: "deoxyribonucleoside monophosphokinase activity" EXACT [EC:2.7.4.13] +xref: EC:2.7.4.13 +xref: MetaCyc:(DEOXY)NUCLEOSIDE-PHOSPHATE-KINASE-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0047508 +name: (R)-2-methylmalate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-methylmalate = 2-methylmaleate + H2O." [EC:4.2.1.35, MetaCyc:(R)-2-METHYLMALATE-DEHYDRATASE-RXN] +synonym: "(-)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] +synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" EXACT [EC:4.2.1.35] +synonym: "(R)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.35] +synonym: "citraconase activity" EXACT [EC:4.2.1.35] +synonym: "citraconate hydratase activity" EXACT [EC:4.2.1.35] +synonym: "citramalate hydro-lyase activity" EXACT [EC:4.2.1.35] +xref: EC:4.2.1.35 +xref: MetaCyc:(R)-2-METHYLMALATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047509 +name: (R)-dehydropantoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + H+." [EC:1.2.1.33, MetaCyc:(R)-DEHYDROPANTOATE-DEHYDROGENASE-RXN] +synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.2.1.33] +synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" EXACT [EC:1.2.1.33] +synonym: "D-aldopantoate dehydrogenase activity" EXACT [EC:1.2.1.33] +xref: EC:1.2.1.33 +xref: MetaCyc:(R)-DEHYDROPANTOATE-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047510 +name: (S)-2-methylmalate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-methylmalate = 2-methylfumarate + H2O." [EC:4.2.1.34, MetaCyc:(S)-2-METHYLMALATE-DEHYDRATASE-RXN] +synonym: "(+)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.34] +synonym: "(+)-citramalic hydro-lyase activity" EXACT [EC:4.2.1.34] +synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" EXACT [EC:4.2.1.34] +synonym: "(S)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.34] +synonym: "citramalate dehydratase activity" EXACT [EC:4.2.1.34] +synonym: "L-citramalate hydrolase activity" EXACT [EC:4.2.1.34] +synonym: "mesaconase activity" EXACT [EC:4.2.1.34] +synonym: "mesaconate hydratase activity" EXACT [EC:4.2.1.34] +synonym: "mesaconate mesaconase activity" EXACT [EC:4.2.1.34] +xref: EC:4.2.1.34 +xref: MetaCyc:(S)-2-METHYLMALATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047511 +name: (S)-methylmalonyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = methylmalonate + CoA." [EC:3.1.2.17, MetaCyc:(S)-METHYLMALONYL-COA-HYDROLASE-RXN] +synonym: "D-methylmalonyl-coenzyme A hydrolase activity" EXACT [EC:3.1.2.17] +xref: EC:3.1.2.17 +xref: MetaCyc:(S)-METHYLMALONYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047512 +name: (S,S)-butanediol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + NADH + H+." [EC:1.1.1.76, MetaCyc:(S\,S)-BUTANEDIOL-DEHYDROGENASE-RXN] +synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.76] +synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" EXACT [EC:1.1.1.76] +synonym: "L-BDH" RELATED [EC:1.1.1.76] +synonym: "L-butanediol dehydrogenase activity" EXACT [EC:1.1.1.76] +xref: EC:1.1.1.76 +xref: MetaCyc:(S\,S)-BUTANEDIOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047513 +name: 1,2-alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:1\,2-ALPHA-L-FUCOSIDASE-RXN] +synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" EXACT [EC:3.2.1.63] +synonym: "almond emulsin fucosidase activity" EXACT [EC:3.2.1.63] +synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63] +synonym: "alpha-(1->2)-L-fucosidase activity" EXACT [EC:3.2.1.63] +xref: EC:3.2.1.63 +xref: MetaCyc:1\,2-ALPHA-L-FUCOSIDASE-RXN +is_a: GO:0004560 ! alpha-L-fucosidase activity + +[Term] +id: GO:0047514 +name: 1,3-beta-D-glucan phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:1\,3-BETA-GLUCAN-PHOSPHORYLASE-RXN] +synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.97] +synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.97] +synonym: "1,3-beta-glucan phosphorylase activity" EXACT [] +synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97] +synonym: "laminarin phosphoryltransferase activity" EXACT [EC:2.4.1.97] +xref: EC:2.4.1.97 +xref: MetaCyc:1\,3-BETA-GLUCAN-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0047515 +name: 1,3-beta-oligoglucan phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oligomeric 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:1\,3-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN] +synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.30] +synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30] +synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30] +xref: EC:2.4.1.30 +xref: MetaCyc:1\,3-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0047516 +name: 1,3-propanediol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:1\,3-PROPANEDIOL-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "1,3-PD:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] +synonym: "1,3-propanediol oxidoreductase activity" EXACT [EC:1.1.1.202] +synonym: "1,3-propanediol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202] +synonym: "3-hydroxypropionaldehyde reductase activity" EXACT [EC:1.1.1.202] +synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.202] +xref: EC:1.1.1.202 +xref: MetaCyc:1\,3-PROPANEDIOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047517 +name: 1,4-beta-D-xylan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-xylose + 1,4-beta-D-xylan(n) = UDP + 1,4-beta-D-xylan(n+1)." [EC:2.4.2.24, MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN] +synonym: "1,4-beta-xylan synthase activity" EXACT [EC:2.4.2.24] +synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.24] +synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" EXACT [EC:2.4.2.24] +synonym: "xylan synthase activity" EXACT [EC:2.4.2.24] +synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24] +xref: EC:2.4.2.24 +xref: MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047518 +name: 1-methyladenosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + D-ribose." [EC:3.2.2.13, MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN] +synonym: "1-methyladenosine hydrolase activity" EXACT [EC:3.2.2.13] +synonym: "1-methyladenosine ribohydrolase activity" EXACT [EC:3.2.2.13] +xref: EC:3.2.2.13 +xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047519 +name: quinate dehydrogenase (pyrroloquinoline-quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: quinate + pyrroloquinoline-quinone = 5-dehydroquinate + reduced pyrroloquinoline-quinone." [EC:1.1.99.25, MetaCyc:1.1.99.25-RXN] +subset: gosubset_prok +synonym: "NAD(P)-independent quinate dehydrogenase activity" EXACT [EC:1.1.99.25] +synonym: "quinate:pyrroloquinoline-quinone 3-oxidoreductase activity" EXACT [EC:1.1.99.25] +synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" EXACT [EC:1.1.99.25] +xref: EC:1.1.99.25 +xref: MetaCyc:1.1.99.25-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047520 +name: 11-cis-retinyl-palmitate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + palmitate." [EC:3.1.1.63, MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN] +synonym: "11-cis-retinol palmitate esterase activity" EXACT [EC:3.1.1.63] +synonym: "11-cis-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.63] +synonym: "RPH" RELATED [EC:3.1.1.63] +xref: EC:3.1.1.63 +xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047521 +name: 12-beta-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-alpha,7-alpha,12-beta-trihydroxy-5-beta-cholanate + NADP+ = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + NADPH + H+." [EC:1.1.1.238, MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN] +synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.238] +synonym: "12beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.238] +synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" EXACT [EC:1.1.1.238] +xref: EC:1.1.1.238 +xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047522 +name: 15-oxoprostaglandin 13-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] +synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48] +synonym: "15-ketoprostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] +synonym: "15-oxo-delta13-prostaglandin reductase activity" EXACT [EC:1.3.1.48] +synonym: "15-oxoprostaglandin 13-reductase activity" EXACT [] +synonym: "delta13-15-ketoprostaglandin reductase activity" EXACT [EC:1.3.1.48] +synonym: "prostaglandin 13-reductase activity" EXACT [EC:1.3.1.48] +synonym: "prostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48] +xref: EC:1.3.1.48 +xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047524 +name: 16-hydroxysteroid epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN] +synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2] +xref: EC:5.1.99.2 +xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0047525 +name: 2'-hydroxydaidzein reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN] +synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] +synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] +synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51] +synonym: "HDR activity" EXACT [EC:1.3.1.51] +synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" EXACT [EC:1.3.1.51] +xref: EC:1.3.1.51 +xref: MetaCyc:RXN-4502 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047526 +name: 2'-hydroxyisoflavone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2'-HYDROXYISOFLAVONE-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" EXACT [EC:1.3.1.45] +synonym: "isoflavone reductase activity" EXACT [EC:1.3.1.45] +synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" EXACT [EC:1.3.1.45] +synonym: "vestitone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.45] +xref: EC:1.3.1.45 +xref: MetaCyc:2'-HYDROXYISOFLAVONE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047527 +name: 2,3-dihydroxybenzoate-serine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN] +synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" EXACT [EC:6.3.2.14] +synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14] +synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14] +xref: EC:6.3.2.14 +xref: MetaCyc:2\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047528 +name: 2,3-dihydroxyindole 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2." [EC:1.13.11.23, MetaCyc:2\,3-DIHYDROXYINDOLE-2\,3-DIOXYGENASE-RXN] +synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" EXACT [EC:1.13.11.23] +xref: EC:1.13.11.23 +xref: MetaCyc:2\,3-DIHYDROXYINDOLE-2\,3-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047529 +name: 2,3-dimethylmalate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, MetaCyc:2\,3-DIMETHYLMALATE-LYASE-RXN] +synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" EXACT [EC:4.1.3.32] +synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] +synonym: "2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32] +xref: EC:4.1.3.32 +xref: MetaCyc:2\,3-DIMETHYLMALATE-LYASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047530 +name: 2,4-diaminopentanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:2\,4-DIAMINOPENTANOATE-DEHYDROGENASE-RXN] +synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.12] +synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" EXACT [EC:1.4.1.12] +xref: EC:1.4.1.12 +xref: MetaCyc:2\,4-DIAMINOPENTANOATE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047531 +name: 2,5-diaminovalerate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, MetaCyc:2\,5-DIAMINOVALERATE-AMINOTRANSFERASE-RXN] +synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.8] +synonym: "2,5-diaminovalerate aminotransferase activity" EXACT [] +synonym: "diamino acid aminotransferase activity" EXACT [EC:2.6.1.8] +synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8] +synonym: "diamino-acid transaminase activity" EXACT [EC:2.6.1.8] +xref: EC:2.6.1.8 +xref: MetaCyc:2\,5-DIAMINOVALERATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047532 +name: 2,5-dioxopiperazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine." [EC:3.5.2.13, MetaCyc:2\,5-DIOXOPIPERAZINE-HYDROLASE-RXN] +synonym: "2,5-dioxopiperazine amidohydrolase activity" EXACT [EC:3.5.2.13] +synonym: "cyclo(Gly-Gly) hydrolase activity" EXACT [EC:3.5.2.13] +synonym: "cyclo(glycylglycine) hydrolase activity" EXACT [EC:3.5.2.13] +xref: EC:3.5.2.13 +xref: MetaCyc:2\,5-DIOXOPIPERAZINE-HYDROLASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047533 +name: 2,5-dioxovalerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, MetaCyc:2\,5-DIOXOVALERATE-DEHYDROGENASE-RXN] +synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" EXACT [EC:1.2.1.26] +synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] +synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26] +xref: EC:1.2.1.26 +xref: MetaCyc:2\,5-DIOXOVALERATE-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047534 +name: 2-acetolactate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN] +synonym: "2-acetolactate methylmutase activity" EXACT [EC:5.4.99.3] +synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3] +synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3] +xref: EC:5.4.99.3 +xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047535 +name: 2-alkyn-1-ol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+." [EC:1.1.1.165, MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN] +synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.165] +xref: EC:1.1.1.165 +xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047536 +name: 2-aminoadipate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN] +synonym: "2-aminoadipate aminotransferase activity" EXACT [] +synonym: "2-aminoadipic aminotransferase activity" EXACT [EC:2.6.1.39] +synonym: "alpha-aminoadipate aminotransferase activity" EXACT [EC:2.6.1.39] +synonym: "glutamate-alpha-ketoadipate transaminase activity" EXACT [EC:2.6.1.39] +synonym: "glutamic-ketoadipic transaminase activity" EXACT [EC:2.6.1.39] +synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.39] +xref: EC:2.6.1.39 +xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047537 +name: 2-aminohexanoate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN] +synonym: "2-aminohexanoate aminotransferase activity" EXACT [] +synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] +synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67] +synonym: "norleucine (leucine) aminotransferase activity" EXACT [EC:2.6.1.67] +synonym: "norleucine aminotransferase activity" EXACT [EC:2.6.1.67] +synonym: "norleucine transaminase activity" EXACT [EC:2.6.1.67] +xref: EC:2.6.1.67 +xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047538 +name: 2-carboxy-D-arabinitol-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN] +synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.63] +synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.63] +synonym: "2-carboxyarabinitol 1-phosphatase activity" EXACT [EC:3.1.3.63] +xref: EC:3.1.3.63 +xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047539 +name: 2-deoxyglucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN] +synonym: "2-deoxy-alpha-D-glucosidase activity" EXACT [EC:3.2.1.112] +synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.1.112] +synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112] +xref: EC:3.2.1.112 +xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047540 +name: 2-enoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "butanoate:NAD+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.31] +synonym: "enoate reductase activity" EXACT [EC:1.3.1.31] +xref: EC:1.3.1.31 +xref: MetaCyc:2-ENOATE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047541 +name: 2-furoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-furoate + CoA = AMP + diphosphate + 2-furoyl-CoA." [EC:6.2.1.31, MetaCyc:2-FUROATE--COA-LIGASE-RXN] +synonym: "2-furoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.31] +synonym: "2-furoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.31] +xref: EC:6.2.1.31 +xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047542 +name: 2-furoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor." [EC:1.3.99.8, MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN] +synonym: "2-furoyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.8] +synonym: "2-furoyl coenzyme A hydroxylase activity" EXACT [EC:1.3.99.8] +synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] +synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8] +synonym: "furoyl-CoA hydroxylase activity" EXACT [EC:1.3.99.8] +xref: EC:1.3.99.8 +xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047543 +name: 2-hexadecenal reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecanal + NADP+ = 2-trans-hexadecenal + NADPH + H+." [EC:1.3.1.27, MetaCyc:2-HEXADECENAL-REDUCTASE-RXN] +synonym: "hexadecanal: NADP+ oxidoreductase activity" EXACT [EC:1.3.1.27] +synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.27] +xref: EC:1.3.1.27 +xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047544 +name: 2-hydroxybiphenyl 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxybiphenyl + NADH + H+ + O2 = 2,3-dihydroxybiphenyl + NAD+ + H2O." [EC:1.14.13.44, MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN] +synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44] +xref: EC:1.14.13.44 +xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0896 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047545 +name: 2-hydroxyglutarate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.2] +synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.2] +synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2] +synonym: "alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] +synonym: "alpha-hydroxyglutarate oxidoreductase activity" EXACT [EC:1.1.99.2] +synonym: "alpha-ketoglutarate reductase activity" EXACT [EC:1.1.99.2] +synonym: "hydroxyglutaric dehydrogenase activity" EXACT [EC:1.1.99.2] +synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2] +synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2] +xref: EC:1.1.99.2 +xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047546 +name: 2-hydroxypyridine 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxypyridine + donor-H2 + O2 = 2,5-dihydroxypyridine + acceptor + H2O." [EC:1.14.99.26, MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN] +synonym: "2-hydroxypyridine oxygenase activity" EXACT [EC:1.14.99.26] +synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.99.26] +xref: EC:1.14.99.26 +xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047547 +name: 2-methylcitrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O." [EC:4.2.1.79, MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN] +subset: gosubset_prok +synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79] +synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.79] +synonym: "2-methylcitrate hydro-lyase activity" EXACT [EC:4.2.1.79] +synonym: "prpD" RELATED [EC:4.2.1.79] +xref: EC:4.2.1.79 +xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047548 +name: 2-methyleneglutarate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN] +subset: gosubset_prok +synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" EXACT [EC:5.4.99.4] +synonym: "alpha-methyleneglutarate mutase activity" EXACT [EC:5.4.99.4] +xref: EC:5.4.99.4 +xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047549 +name: 2-nitrophenol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-nitrophenol + NADPH + H+ + O2 = catechol + NO2(-) (nitrite) + NADP+ + H2O." [EC:1.14.13.31, MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN] +synonym: "2-nitrophenol oxygenase activity" EXACT [EC:1.14.13.31] +synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" EXACT [EC:1.14.13.31] +synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31] +xref: EC:1.14.13.31 +xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0951 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047550 +name: 2-oxoadipate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + NADH + H+." [EC:1.1.1.172, MetaCyc:2-OXOADIPATE-REDUCTASE-RXN] +synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.172] +synonym: "2-ketoadipate reductase activity" EXACT [EC:1.1.1.172] +synonym: "alpha-ketoadipate reductase activity" EXACT [EC:1.1.1.172] +xref: EC:1.1.1.172 +xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047551 +name: 2-oxoaldehyde dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NAD+)-RXN] +synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23] +synonym: "2-oxoaldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.23] +synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" EXACT [EC:1.2.1.23] +synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23] +synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23] +synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] +synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23] +xref: EC:1.2.1.23 +xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NAD+)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047552 +name: 2-oxoaldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NADP+)-RXN] +synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49] +synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" EXACT [EC:1.2.1.49] +synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49] +synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49] +synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] +synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49] +xref: EC:1.2.1.49 +xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047553 +name: 2-oxoglutarate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN] +subset: gosubset_prok +synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] +synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] +synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.7.3] +synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" EXACT [EC:1.2.7.3] +synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] +synonym: "alpha-ketoglutarate synthase activity" EXACT [EC:1.2.7.3] +synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3] +synonym: "KGOR activity" EXACT [EC:1.2.7.3] +xref: EC:1.2.7.3 +xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0047554 +name: 2-pyrone-4,6-dicarboxylate lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate." [EC:3.1.1.57, MetaCyc:2-PYRONE-4\,6-DICARBOXYLATE-LACTONASE-RXN] +subset: gosubset_prok +synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" EXACT [EC:3.1.1.57] +xref: EC:3.1.1.57 +xref: MetaCyc:2-PYRONE-4\,6-DICARBOXYLATE-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047555 +name: 3',5'-cyclic-GMP phosphodiesterase activity +namespace: molecular_function +alt_id: GO:0004116 +def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:3'\,5'-CYCLIC-GMP-PHOSPHODIESTERASE-RXN] +synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT [] +synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.35] +synonym: "cGMP phosphodiesterase activity" EXACT [] +synonym: "cGMP-PDE" RELATED [EC:3.1.4.35] +synonym: "cGMP-specific phosphodiesterase activity" EXACT [] +synonym: "cyclic 3',5'-GMP phosphodiesterase activity" EXACT [EC:3.1.4.35] +synonym: "cyclic GMP phosphodiesterase activity" EXACT [] +synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] +synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.35] +synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.35 +xref: MetaCyc:3'\,5'-CYCLIC-GMP-PHOSPHODIESTERASE-RXN +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0047556 +name: 3,4-dihydroxyphthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.69] +synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.69] +synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.69] +xref: EC:4.1.1.69 +xref: MetaCyc:3\,4-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0916 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047557 +name: 3-aci-nitropropanoate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + O2 + 3-aci-nitropropanoate = NO2(-) (nitrite) + H2O2 + 3-oxopropanoate." [EC:1.7.3.5, MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN] +synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.5] +synonym: "propionate-3-nitronate oxidase activity" EXACT [EC:1.7.3.5] +xref: EC:1.7.3.5 +xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0047558 +name: 3-cyanoalanine hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine = 3-cyanoalanine + H2O." [EC:4.2.1.65, MetaCyc:3-CYANOALANINE-HYDRATASE-RXN] +synonym: "beta-CNA nitrilase activity" EXACT [EC:4.2.1.65] +synonym: "beta-CNAla hydrolase activity" EXACT [EC:4.2.1.65] +synonym: "beta-cyanoalanine hydratase activity" EXACT [EC:4.2.1.65] +synonym: "beta-cyanoalanine hydrolase activity" EXACT [EC:4.2.1.65] +synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" EXACT [EC:4.2.1.65] +synonym: "L-asparagine hydro-lyase activity" EXACT [EC:4.2.1.65] +xref: EC:4.2.1.65 +xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047559 +name: 3-dehydro-L-gulonate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN] +synonym: "2,3-diketo-L-gulonate reductase activity" EXACT [EC:1.1.1.130] +synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.130] +synonym: "3-keto-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.130] +synonym: "3-ketogulonate dehydrogenase activity" EXACT [EC:1.1.1.130] +xref: EC:1.1.1.130 +xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047560 +name: 3-dehydrosphinganine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+." [EC:1.1.1.102, MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN] +synonym: "3-ketosphinganine reductase activity" EXACT [EC:1.1.1.102] +synonym: "3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] +synonym: "3-oxosphinganine:NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] +synonym: "D-3-dehydrosphinganine reductase activity" EXACT [EC:1.1.1.102] +synonym: "D-3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102] +synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" EXACT [EC:1.1.1.102] +synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.102] +synonym: "DSR activity" EXACT [EC:1.1.1.102] +synonym: "KTS reductase activity" RELATED [EC:1.1.1.102] +xref: EC:1.1.1.102 +xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047561 +name: 3-hydroxyanthranilate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2." [EC:1.10.3.5, MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN] +synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.5] +synonym: "3-hydroxyanthranilic acid oxidase activity" EXACT [EC:1.10.3.5] +xref: EC:1.10.3.5 +xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0047562 +name: 3-hydroxyaspartate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN] +synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] +synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" EXACT [EC:4.1.3.14] +synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14] +synonym: "erythro-beta-hydroxyaspartate aldolase activity" EXACT [EC:4.1.3.14] +synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" EXACT [EC:4.1.3.14] +xref: EC:4.1.3.14 +xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047563 +name: 3-hydroxybenzoate 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoate + donor-H2 + O2 = 2,3-dihydroxybenzoate + acceptor + H2O." [EC:1.14.99.23, MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN] +synonym: "3-HBA-2-hydroxylase activity" EXACT [EC:1.14.99.23] +synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT [] +synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.23] +xref: EC:1.14.99.23 +xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047564 +name: 3-hydroxycyclohexanone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxycyclohexanone + acceptor = cyclohexane-1,3-dione + reduced acceptor." [EC:1.1.99.26, MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN] +synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.26] +xref: EC:1.1.99.26 +xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047565 +name: 3-hydroxypropionate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+." [EC:1.1.1.59, MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN] +synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.59] +xref: EC:1.1.1.59 +xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047566 +name: 3-ketovalidoxylamine C-N-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one." [EC:4.3.3.1, MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN] +synonym: "3-ketovalidoxylamine A C-N-lyase activity" EXACT [EC:4.3.3.1] +synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1] +synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" EXACT [EC:4.3.3.1] +synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" EXACT [EC:4.3.3.1] +xref: EC:4.3.3.1 +xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0047567 +name: 3-methyleneoxindole reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + NADPH + H+." [EC:1.3.1.17, MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN] +synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] +synonym: "3-methyloxindole:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17] +xref: EC:1.3.1.17 +xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047568 +name: 3-oxo-5-beta-steroid 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN] +synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.6] +synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] +synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.6] +synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6] +xref: EC:1.3.99.6 +xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN +is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047569 +name: 3-oxoadipate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN] +subset: gosubset_prok +synonym: "3-oxoadipate coenzyme A-transferase activity" EXACT [EC:2.8.3.6] +synonym: "3-oxoadipate succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] +synonym: "beta-ketoadipate:succinyl-CoA transferase activity" EXACT [EC:2.8.3.6] +synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" EXACT [EC:2.8.3.6] +xref: EC:2.8.3.6 +xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN +xref: UM-BBD_enzymeID:e0654 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047570 +name: 3-oxoadipate enol-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN] +subset: gosubset_prok +synonym: "3-ketoadipate enol-lactonase activity" EXACT [EC:3.1.1.24] +synonym: "3-oxoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] +synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" EXACT [EC:3.1.1.24] +synonym: "beta-ketoadipate enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] +synonym: "beta-ketoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24] +synonym: "carboxymethylbutenolide lactonase activity" EXACT [EC:3.1.1.24] +xref: EC:3.1.1.24 +xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047571 +name: 3-oxosteroid 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "1-ene-dehydrogenase activity" EXACT [EC:1.3.99.4] +synonym: "3-ketosteroid-1-en-dehydrogenase activity" EXACT [EC:1.3.99.4] +synonym: "3-ketosteroid-delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] +synonym: "3-oxosteroid delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] +synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] +synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] +synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" EXACT [EC:1.3.99.4] +synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" EXACT [EC:1.3.99.4] +synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4] +synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4] +xref: EC:1.3.99.4 +xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0712 +is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047572 +name: 3-phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate 3-phosphate + H2O = D-glycerate + phosphate." [EC:3.1.3.38, MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN] +synonym: "3-PGA phosphatase activity" EXACT [EC:3.1.3.38] +synonym: "D-3-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.38] +synonym: "D-glycerate-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.38] +xref: EC:3.1.3.38 +xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047573 +name: 4-acetamidobutyrate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN] +synonym: "4-acetamidobutanoate amidohydrolase activity" EXACT [EC:3.5.1.63] +xref: EC:3.5.1.63 +xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047574 +name: 4-acetamidobutyryl-CoA deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-acetamidobutanoyl + H2O = acetate + 4-aminobutanoyl-CoA." [EC:3.5.1.51, MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN] +synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" EXACT [EC:3.5.1.51] +synonym: "aminobutyryl-CoA thiolesterase activity" EXACT [EC:3.5.1.51] +synonym: "deacetylase-thiolesterase activity" EXACT [EC:3.5.1.51] +xref: EC:3.5.1.51 +xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047575 +name: 4-carboxymuconolactone decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2." [EC:4.1.1.44, MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN] +subset: gosubset_prok +synonym: "4-carboxymonolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] +synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" EXACT [EC:4.1.1.44] +synonym: "4-carboxymuconolactone carboxy-lyase activity" EXACT [EC:4.1.1.44] +synonym: "gamma-4-carboxymuconolactone decarboxylase activity" EXACT [EC:4.1.1.44] +xref: EC:4.1.1.44 +xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047576 +name: 4-chlorobenzoate dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride." [EC:3.8.1.6, MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN] +synonym: "4-chlorobenzoate chlorohydrolase activity" EXACT [EC:3.8.1.6] +synonym: "halobenzoate dehalogenase activity" EXACT [EC:3.8.1.6] +xref: EC:3.8.1.6 +xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0047577 +name: 4-hydroxybutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+." [EC:1.1.1.61, MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.61] +synonym: "gamma-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.61] +xref: EC:1.1.1.61 +xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047578 +name: 4-hydroxyglutamate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN] +synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.23] +synonym: "4-hydroxyglutamate aminotransferase activity" EXACT [] +xref: EC:2.6.1.23 +xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047579 +name: 4-hydroxymandelate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2." [EC:1.1.3.19, MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN] +synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.19] +synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" EXACT [EC:1.1.3.19] +xref: EC:1.1.3.19 +xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047580 +name: 4-hydroxyproline epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN] +synonym: "4-hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] +synonym: "hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8] +synonym: "hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] +synonym: "L-hydroxyproline epimerase activity" EXACT [EC:5.1.1.8] +xref: EC:5.1.1.8 +xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047581 +name: 4-methyleneglutamate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-methylene-L-glutamate + NH3 = AMP + diphosphate + 4-methylene-L-glutamine." [EC:6.3.1.7, MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN] +subset: gosubset_prok +synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.7] +synonym: "4-methyleneglutamine synthetase activity" EXACT [EC:6.3.1.7] +xref: EC:6.3.1.7 +xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047582 +name: 4-methyleneglutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3." [EC:3.5.1.67, MetaCyc:4-METHYLENEGLUTAMINASE-RXN] +synonym: "4-methylene-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.67] +synonym: "4-methyleneglutamine amidohydrolase activity" EXACT [EC:3.5.1.67] +synonym: "4-methyleneglutamine deamidase activity" EXACT [EC:3.5.1.67] +xref: EC:3.5.1.67 +xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047583 +name: 4-methyloxaloacetate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetate 4-methyl ester + H2O = oxaloacetate + methanol." [EC:3.1.1.44, MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN] +synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" EXACT [EC:3.1.1.44] +xref: EC:3.1.1.44 +xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047584 +name: 4-oxalmesaconate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.83, MetaCyc:4-OXALMESACONATE-HYDRATASE-RXN] +subset: gosubset_prok +synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83] +synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] +synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83] +synonym: "4-carboxy-2-oxohexenedioate hydratase activity" EXACT [EC:4.2.1.83] +synonym: "gamma-oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] +synonym: "oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83] +xref: EC:4.2.1.83 +xref: MetaCyc:4-OXALMESACONATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047585 +name: 4-pyridoxolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate." [EC:3.1.1.27, MetaCyc:4-PYRIDOXOLACTONASE-RXN] +synonym: "4-pyridoxolactone lactonohydrolase activity" EXACT [EC:3.1.1.27] +xref: EC:3.1.1.27 +xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047586 +name: 5'-acylphosphoadenosine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5'-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN] +synonym: "5'-acylphosphoadenosine acylhydrolase activity" EXACT [EC:3.6.1.20] +synonym: "5-phosphoadenosine hydrolase activity" EXACT [EC:3.6.1.20] +xref: EC:3.6.1.20 +xref: MetaCyc:5'-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0047587 +name: 5-alpha-hydroxysteroid dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-ergosta-7,22-diene-3-beta,5-diol = ergosterol + H2O." [EC:4.2.1.62, MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN] +synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" EXACT [EC:4.2.1.62] +synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" EXACT [EC:4.2.1.62] +synonym: "5alpha-hydroxysteroid dehydratase activity" EXACT [EC:4.2.1.62] +xref: EC:4.2.1.62 +xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047588 +name: 5-aminopentanamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN] +synonym: "5-aminonorvaleramidase activity" EXACT [EC:3.5.1.30] +synonym: "5-aminopentanamide amidohydrolase activity" EXACT [EC:3.5.1.30] +synonym: "5-aminovaleramidase activity" EXACT [EC:3.5.1.30] +xref: EC:3.5.1.30 +xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047589 +name: 5-aminovalerate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, MetaCyc:5-AMINOVALERATE-AMINOTRANSFERASE-RXN] +synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.48] +synonym: "5-aminovalerate aminotransferase activity" EXACT [] +synonym: "delta-aminovalerate aminotransferase activity" EXACT [EC:2.6.1.48] +synonym: "delta-aminovalerate transaminase activity" EXACT [EC:2.6.1.48] +xref: EC:2.6.1.48 +xref: MetaCyc:5-AMINOVALERATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047590 +name: 5-dehydro-2-deoxygluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN] +subset: gosubset_prok +synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" EXACT [EC:2.7.1.92] +synonym: "5-keto-2-deoxygluconokinase activity" EXACT [EC:2.7.1.92] +synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.92] +synonym: "DKH kinase activity" EXACT [EC:2.7.1.92] +xref: EC:2.7.1.92 +xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047591 +name: 5-hydroxypentanoate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxy-pentanoyl-CoA." [EC:2.8.3.14, MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN] +synonym: "5-hydroxyvalerate CoA-transferase activity" EXACT [EC:2.8.3.14] +synonym: "5-hydroxyvalerate coenzyme A transferase activity" EXACT [EC:2.8.3.14] +synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" EXACT [EC:2.8.3.14] +xref: EC:2.8.3.14 +xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047592 +name: 5-pyridoxate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+." [EC:1.14.12.5, MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN] +synonym: "5-pyridoxate oxidase activity" EXACT [EC:1.14.12.5] +synonym: "5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.5] +xref: EC:1.14.12.5 +xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0047593 +name: 6-acetylglucose deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate." [EC:3.1.1.33, MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN] +synonym: "6-acetyl-D-glucose acetylhydrolase activity" EXACT [EC:3.1.1.33] +synonym: "6-O-acetylglucose deacetylase activity" EXACT [EC:3.1.1.33] +xref: EC:3.1.1.33 +xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047594 +name: 6-beta-hydroxyhyoscyamine epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2." [EC:1.14.11.14, MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN] +synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" EXACT [EC:1.14.11.14] +synonym: "6beta-hydroxyhyoscyamine epoxidase activity" EXACT [EC:1.14.11.14] +synonym: "hydroxyhyoscyamine dioxygenase activity" EXACT [EC:1.14.11.14] +xref: EC:1.14.11.14 +xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0047595 +name: 6-hydroxynicotinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN] +synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] +synonym: "6-hydroxynicotinic reductase activity" EXACT [EC:1.3.7.1] +synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1] +synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] +synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1] +synonym: "HNA reductase activity" EXACT [EC:1.3.7.1] +xref: EC:1.3.7.1 +xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0047596 +name: 6-methylsalicylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-methylsalicylate = 3-cresol + CO2." [EC:4.1.1.52, MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN] +synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" EXACT [EC:4.1.1.52] +synonym: "6-methylsalicylate carboxy-lyase activity" EXACT [EC:4.1.1.52] +synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" EXACT [EC:4.1.1.52] +synonym: "6-MSA decarboxylase activity" EXACT [EC:4.1.1.52] +xref: EC:4.1.1.52 +xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047597 +name: 6-oxocineole dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo-[3.2.2]nonan-3-one + NADP+ + H2O." [EC:1.14.13.51, MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN] +synonym: "6-oxocineole oxygenase activity" EXACT [EC:1.14.13.51] +synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.51] +xref: EC:1.14.13.51 +xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047598 +name: 7-dehydrocholesterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21, MetaCyc:7-DEHYDROCHOLESTEROL-REDUCTASE-RXN] +synonym: "7-DHC reductase activity" EXACT [EC:1.3.1.21] +synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" EXACT [EC:1.3.1.21] +synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21] +synonym: "sterol delta7-reductase activity" EXACT [EC:1.3.1.21] +xref: EC:1.3.1.21 +xref: MetaCyc:7-DEHYDROCHOLESTEROL-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047599 +name: 8-oxocoformycin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + NADPH + H+." [EC:1.1.1.235, MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN] +synonym: "8-ketodeoxycoformycin reductase activity" EXACT [EC:1.1.1.235] +synonym: "coformycin:NADP+ 8-oxidoreductase activity" EXACT [EC:1.1.1.235] +xref: EC:1.1.1.235 +xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047600 +name: abequosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN] +synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" EXACT [EC:2.4.1.60] +synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60] +xref: EC:2.4.1.60 +xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047601 +name: acetate kinase (diphosphate) activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + acetate = phosphate + acetyl phosphate." [EC:2.7.2.12, MetaCyc:ACETATE-KINASE-(PYROPHOSPHATE)-RXN] +synonym: "acetate kinase (pyrophosphate) activity" EXACT [EC:2.7.2.12] +synonym: "diphosphate:acetate phosphotransferase activity" EXACT [EC:2.7.2.12] +synonym: "pyrophosphate-acetate phosphotransferase activity" EXACT [EC:2.7.2.12] +xref: EC:2.7.2.12 +xref: MetaCyc:ACETATE-KINASE-(PYROPHOSPHATE)-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047602 +name: acetoacetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetate + H+ = acetone + CO2." [EC:4.1.1.4, MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN] +subset: gosubset_prok +synonym: "acetoacetate carboxy-lyase (acetone-forming)" EXACT [EC:4.1.1.4] +synonym: "acetoacetate carboxy-lyase activity" EXACT [EC:4.1.1.4] +synonym: "acetoacetic acid decarboxylase activity" EXACT [EC:4.1.1.4] +xref: EC:4.1.1.4 +xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047603 +name: acetoacetyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetyl-CoA + H2O = CoA + acetoacetate." [EC:3.1.2.11, MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN] +synonym: "acetoacetyl CoA deacylase activity" EXACT [EC:3.1.2.11] +synonym: "acetoacetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.11] +synonym: "acetoacetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.11] +xref: EC:3.1.2.11 +xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047604 +name: acetoin racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, MetaCyc:ACETOIN-RACEMASE-RXN] +synonym: "acetylmethylcarbinol racemase activity" EXACT [EC:5.1.2.4] +xref: EC:5.1.2.4 +xref: MetaCyc:ACETOIN-RACEMASE-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0047605 +name: acetolactate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN] +subset: gosubset_prok +synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5] +synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.5] +synonym: "alpha-acetolactate decarboxylase activity" EXACT [EC:4.1.1.5] +xref: EC:4.1.1.5 +xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047606 +name: acetone-cyanhydrin lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetone cyanhydrin = cyanide + acetone." [EC:4.1.2.37, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN] +synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" EXACT [EC:4.1.2.37] +synonym: "acetone-cyanohydrin acetone-lyase activity" EXACT [EC:4.1.2.37] +synonym: "acetone-cyanohydrin lyase activity" EXACT [] +synonym: "alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.37] +xref: EC:4.1.2.37 +xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047608 +name: acetylindoxyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN] +synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" EXACT [EC:1.7.3.2] +xref: EC:1.7.3.2 +xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0047609 +name: acetylputrescine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine." [EC:3.5.1.62, MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN] +synonym: "N-acetylputrescine acetylhydrolase activity" EXACT [EC:3.5.1.62] +xref: EC:3.5.1.62 +xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047610 +name: acetylsalicylate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetylsalicylate + H2O = salicylate + acetate." [EC:3.1.1.55, MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN] +synonym: "acetylsalicylate O-acetylhydrolase activity" EXACT [EC:3.1.1.55] +synonym: "acetylsalicylic acid esterase activity" EXACT [EC:3.1.1.55] +synonym: "aspirin esterase activity" EXACT [EC:3.1.1.55] +synonym: "aspirin hydrolase activity" EXACT [EC:3.1.1.55] +xref: EC:3.1.1.55 +xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047611 +name: acetylspermidine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-acetylspermidine + H2O = acetate + spermidine." [EC:3.5.1.48, MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN] +subset: gosubset_prok +synonym: "8-N-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] +synonym: "N(1)-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] +synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] +synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] +synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] +synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48] +synonym: "N1-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] +synonym: "N8-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48] +synonym: "N8-acetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] +synonym: "N8-monoacetylspermidine deacetylase activity" EXACT [EC:3.5.1.48] +xref: EC:3.5.1.48 +xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047612 +name: acid-CoA ligase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + an acid + CoA = GDP + phosphate + acyl-CoA." [EC:6.2.1.10, MetaCyc:ACID--COA-LIGASE-(GDP-FORMING)-RXN] +synonym: "acid:CoA ligase (GDP-forming)" EXACT [EC:6.2.1.10] +synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" EXACT [EC:6.2.1.10] +synonym: "acyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.10] +xref: EC:6.2.1.10 +xref: MetaCyc:ACID--COA-LIGASE-(GDP-FORMING)-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047613 +name: aconitate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-aconitate = itaconate + CO2." [EC:4.1.1.6, MetaCyc:ACONITATE-DECARBOXYLASE-RXN] +synonym: "CAD activity" BROAD [EC:4.1.1.6] +synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" EXACT [EC:4.1.1.6] +synonym: "cis-aconitate carboxy-lyase activity" EXACT [EC:4.1.1.6] +synonym: "cis-aconitic decarboxylase activity" EXACT [EC:4.1.1.6] +xref: EC:4.1.1.6 +xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047614 +name: aconitate delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN] +synonym: "aconitate D-isomerase activity" EXACT [] +synonym: "aconitate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.7] +synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7] +xref: EC:5.3.3.7 +xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0047615 +name: actinomycin lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN] +synonym: "actinomycin lactonohydrolase activity" EXACT [EC:3.1.1.39] +xref: EC:3.1.1.39 +xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047616 +name: acyl-CoA dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-(NADP+)-RXN] +synonym: "2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.8] +synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" EXACT [EC:1.3.1.8] +synonym: "crotonyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] +synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.8] +synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8] +xref: EC:1.3.1.8 +xref: MetaCyc:ACYL-COA-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047617 +name: acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN] +subset: gosubset_prok +synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20] +synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20] +synonym: "thioesterase B" RELATED [EC:3.1.2.20] +synonym: "thioesterase II" RELATED [EC:3.1.2.20] +xref: EC:3.1.2.20 +xref: MetaCyc:ACYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047618 +name: acylagmatine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoylagmatine + H2O = benzoate + agmatine." [EC:3.5.1.40, MetaCyc:ACYLAGMATINE-AMIDASE-RXN] +synonym: "acylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] +synonym: "acylagmatine deacylase activity" EXACT [EC:3.5.1.40] +synonym: "benzoylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40] +xref: EC:3.5.1.40 +xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047619 +name: acylcarnitine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN] +synonym: "carnitine ester hydrolase activity" EXACT [EC:3.1.1.28] +synonym: "HACH" RELATED [EC:3.1.1.28] +synonym: "high activity acylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] +synonym: "long-chain acyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] +synonym: "O-acylcarnitine acylhydrolase activity" EXACT [EC:3.1.1.28] +synonym: "palmitoyl carnitine hydrolase activity" EXACT [EC:3.1.1.28] +synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28] +synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28] +xref: EC:3.1.1.28 +xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047620 +name: acylglycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] +synonym: "ATP:acylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.94] +synonym: "MGK" RELATED [EC:2.7.1.94] +synonym: "monoacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.94] +synonym: "monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] +synonym: "monoglyceride kinase activity" EXACT [EC:2.7.1.94] +synonym: "monoglyceride phosphokinase activity" EXACT [EC:2.7.1.94] +synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94] +xref: EC:2.7.1.94 +xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047621 +name: acylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN] +subset: gosubset_prok +synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5] +xref: EC:3.7.1.5 +xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN +xref: UM-BBD_enzymeID:e0868 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0047622 +name: adenosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN] +synonym: "adenosinase activity" EXACT [EC:3.2.2.7] +synonym: "adenosine hydrolase activity" EXACT [EC:3.2.2.7] +synonym: "adenosine ribohydrolase activity" EXACT [EC:3.2.2.7] +synonym: "ANase activity" EXACT [EC:3.2.2.7] +synonym: "N-ribosyladenine ribohydrolase activity" EXACT [EC:3.2.2.7] +xref: EC:3.2.2.7 +xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047623 +name: adenosine-phosphate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-AMP + H2O = 5'-IMP + NH3." [EC:3.5.4.17, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN] +synonym: "adenine nucleotide deaminase activity" EXACT [EC:3.5.4.17] +synonym: "adenosine (phosphate) deaminase activity" EXACT [EC:3.5.4.17] +synonym: "adenosine-phosphate aminohydrolase activity" EXACT [EC:3.5.4.17] +xref: EC:3.5.4.17 +xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047624 +name: adenosine-tetraphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "adenosine-tetraphosphate phosphohydrolase activity" EXACT [EC:3.6.1.14] +xref: EC:3.6.1.14 +xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047625 +name: adenosylmethionine cyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine = 5'-methylthioadenosine + 2-aminobutan-4-olide." [EC:2.5.1.4, MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN] +synonym: "adenosyl methionine cyclotransferase activity" EXACT [] +synonym: "adenosylmethioninase activity" EXACT [EC:2.5.1.4] +synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" EXACT [EC:2.5.1.4] +xref: EC:2.5.1.4 +xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047626 +name: adenosylmethionine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + S-adenosyl-L-methionine = L-homoserine + methylthioadenosine." [EC:3.3.1.2, MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN] +synonym: "adenosyl methionine hydrolase activity" EXACT [] +synonym: "adenosylmethionine lyase activity" EXACT [EC:3.3.1.2] +synonym: "methylmethionine-sulfonium-salt hydrolase activity" EXACT [EC:3.3.1.2] +synonym: "S-adenosyl-L-methionine hydrolase activity" EXACT [EC:3.3.1.2] +synonym: "S-adenosylmethionine cleaving enzyme activity" EXACT [EC:3.3.1.2] +xref: EC:3.3.1.2 +xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN +is_a: GO:0016802 ! trialkylsulfonium hydrolase activity + +[Term] +id: GO:0047627 +name: adenylylsulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenylylsulfate + H2O = AMP + SO4(2-) (sulfate)." [EC:3.6.2.1, MetaCyc:ADENYLYLSULFATASE-RXN] +synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] +synonym: "adenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.1] +synonym: "adenylylsulphatase activity" EXACT [] +xref: EC:3.6.2.1 +xref: MetaCyc:ADENYLYLSULFATASE-RXN +is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides + +[Term] +id: GO:0047628 +name: ADP-thymidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN] +synonym: "adenosine diphosphate-thymidine phosphotransferase activity" EXACT [EC:2.7.1.118] +synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118] +synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118] +xref: EC:2.7.1.118 +xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047629 +name: ADP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN] +synonym: "adenosine diphosphate deaminase activity" EXACT [EC:3.5.4.7] +synonym: "adenosinepyrophosphate deaminase activity" EXACT [EC:3.5.4.7] +synonym: "ADP aminohydrolase activity" EXACT [EC:3.5.4.7] +xref: EC:3.5.4.7 +xref: MetaCyc:ADP-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047630 +name: ADP-phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate + phosphate." [EC:3.1.3.28, MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN] +synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.28] +synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] +synonym: "ADPphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28] +xref: EC:3.1.3.28 +xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047631 +name: ADP-ribose diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT [] +synonym: "ADP-ribose phosphohydrolase activity" EXACT [] +synonym: "ADP-ribose pyrophosphatase activity" EXACT [] +synonym: "ADP-ribose ribophosphohydrolase activity" EXACT [EC:3.6.1.13] +synonym: "ADPR-PPase activity" EXACT [] +synonym: "ADPribose diphosphatase activity" EXACT [EC:3.6.1.13] +synonym: "ADPribose pyrophosphatase activity" EXACT [EC:3.6.1.13] +xref: EC:3.6.1.13 +xref: MetaCyc:RXN0-1441 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047632 +name: agmatine deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN] +subset: gosubset_prok +synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12] +synonym: "agmatine iminohydrolase activity" EXACT [EC:3.5.3.12] +xref: EC:3.5.3.12 +xref: MetaCyc:AGMATINE-DEIMINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047633 +name: agmatine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + agmatine = ADP + N4-phosphoagmatine." [EC:2.7.3.10, MetaCyc:AGMATINE-KINASE-RXN] +synonym: "ATP:agmatine 4-N-phosphotransferase activity" EXACT [EC:2.7.3.10] +synonym: "ATP:agmatine N4-phosphotransferase activity" EXACT [EC:2.7.3.10] +synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10] +xref: EC:2.7.3.10 +xref: MetaCyc:AGMATINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047634 +name: agmatine N4-coumaroyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = CoA + N-(4-guanidinobutyl)-N4-hydroxycinnamamide." [EC:2.3.1.64, MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN] +synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" EXACT [EC:2.3.1.64] +synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" EXACT [EC:2.3.1.64] +synonym: "agmatine coumaroyltransferase activity" EXACT [EC:2.3.1.64] +synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" EXACT [EC:2.3.1.64] +xref: EC:2.3.1.64 +xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047635 +name: alanine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN] +synonym: "alanine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] +synonym: "alanine-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] +synonym: "alanine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.12] +synonym: "alanine-oxo-acid aminotransferase activity" EXACT [] +synonym: "L-alanine-alpha-keto acid aminotransferase activity" EXACT [EC:2.6.1.12] +synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12] +synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12] +xref: EC:2.6.1.12 +xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047636 +name: alanopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH." [EC:1.5.1.17, MetaCyc:ALANOPINE-DEHYDROGENASE-RXN] +synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" EXACT [EC:1.5.1.17] +synonym: "ADH" RELATED [EC:1.5.1.17] +synonym: "alanopine: NAD oxidoreductase activity" EXACT [EC:1.5.1.17] +synonym: "alanopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.17] +synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" EXACT [EC:1.5.1.17] +synonym: "ALPDH" RELATED [EC:1.5.1.17] +synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.17] +xref: EC:1.5.1.17 +xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047637 +name: alanylphosphatidylglycerol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN] +synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11] +synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [EC:2.3.2.11] +synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11] +xref: EC:2.3.2.11 +xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0047638 +name: albendazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O." [EC:1.14.13.32, MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN] +synonym: "albendazole oxidase activity" EXACT [EC:1.14.13.32] +synonym: "albendazole sulfoxidase activity" EXACT [EC:1.14.13.32] +synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" EXACT [EC:1.14.13.32] +xref: EC:1.14.13.32 +xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047639 +name: alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN] +comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563). +synonym: "alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.13] +synonym: "AOX activity" EXACT [EC:1.1.3.13] +synonym: "ethanol oxidase activity" EXACT [EC:1.1.3.13] +xref: EC:1.1.3.13 +xref: MetaCyc:ALCOHOL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047640 +name: aldose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN] +synonym: "aldose dehydrogenase activity" EXACT [EC:1.1.1.121] +synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121] +synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121] +xref: EC:1.1.1.121 +xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047641 +name: aldose-6-phosphate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NADP+ = D-glucose 6-phosphate + NADPH." [EC:1.1.1.200, MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-(NADPH)-RXN] +synonym: "A6PR" RELATED [EC:1.1.1.200] +synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" EXACT [EC:1.1.1.200] +synonym: "aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] +synonym: "aldose-6-P reductase activity" EXACT [EC:1.1.1.200] +synonym: "aldose-6-phosphate reductase activity" EXACT [EC:1.1.1.200] +synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.200] +synonym: "NADP-dependent aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200] +synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.200] +xref: EC:1.1.1.200 +xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-(NADPH)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047642 +name: aldose beta-D-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN] +synonym: "aldose b-D-fructosyltransferase activity" EXACT [] +synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.162] +xref: EC:2.4.1.162 +xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0047643 +name: alginate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN] +synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC:2.4.1.33] +synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33] +xref: EC:2.4.1.33 +xref: MetaCyc:ALGINATE-SYNTHASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047644 +name: alizarin 2-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + alizarin = UDP + 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone." [EC:2.4.1.103, MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "alizarin 2-b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.103] +synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" EXACT [EC:2.4.1.103] +synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" EXACT [EC:2.4.1.103] +xref: EC:2.4.1.103 +xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047645 +name: alkan-1-ol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-(ACCEPTOR)-RXN] +synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.20] +synonym: "alkan-1-ol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.20] +synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20] +xref: EC:1.1.99.20 +xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-(ACCEPTOR)-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047646 +name: alkanal monooxygenase (FMN-linked) activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-(FMN-LINKED)-RXN] +subset: gosubset_prok +synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3] +synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" EXACT [EC:1.14.14.3] +synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3] +synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3] +xref: EC:1.14.14.3 +xref: MetaCyc:ALKANAL-MONOOXYGENASE-(FMN-LINKED)-RXN +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047647 +name: alkylacetylglycerophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-alkyl-2-acetyl-sn-glycerol + phosphate." [EC:3.1.3.59, MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN] +synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.59] +synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" EXACT [EC:3.1.3.59] +synonym: "alkylacetylglycerophosphate phosphatase activity" EXACT [EC:3.1.3.59] +xref: EC:3.1.3.59 +xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047648 +name: alkylamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylamine." [EC:3.5.1.39, MetaCyc:ALKYLAMIDASE-RXN] +synonym: "N-methylhexanamide amidohydrolase activity" EXACT [EC:3.5.1.39] +xref: EC:3.5.1.39 +xref: MetaCyc:ALKYLAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047649 +name: alkylglycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate." [EC:2.7.1.93, MetaCyc:ALKYLGLYCEROL-KINASE-RXN] +synonym: "1-alkylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.93] +synonym: "alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] +synonym: "ATP-alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93] +synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" EXACT [EC:2.7.1.93] +synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.93] +xref: EC:2.7.1.93 +xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047650 +name: alkylglycerone kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + O-alkylglycerone = ADP + O-alkylglycerone phosphate." [EC:2.7.1.84, MetaCyc:ALKYLGLYCERONE-KINASE-RXN] +synonym: "alkyldihydroxyacetone kinase (phosphorylating)" EXACT [EC:2.7.1.84] +synonym: "alkyldihydroxyacetone kinase activity" EXACT [EC:2.7.1.84] +synonym: "ATP:O-alkylglycerone phosphotransferase activity" EXACT [EC:2.7.1.84] +xref: EC:2.7.1.84 +xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047651 +name: alkylhalidase activity +namespace: molecular_function +def: "Catalysis of the reaction: bromochloromethane + H2O = formaldehyde + bromide + chloride." [EC:3.8.1.1, MetaCyc:ALKYLHALIDASE-RXN] +subset: gosubset_prok +synonym: "alkyl-halide halidohydrolase activity" EXACT [EC:3.8.1.1] +synonym: "haloalkane halidohydrolase activity" EXACT [EC:3.8.1.1] +synonym: "halogenase activity" RELATED [EC:3.8.1.1] +xref: EC:3.8.1.1 +xref: MetaCyc:ALKYLHALIDASE-RXN +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0047652 +name: allantoate deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 2 allantoate = O2 + 2 CO2 + 2 NH3 + 2 ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN] +synonym: "allantoate amidinohydrolase (decarboxylating)" EXACT [EC:3.5.3.9] +synonym: "allantoate amidohydrolase activity" EXACT [EC:3.5.3.9] +xref: EC:3.5.3.9 +xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047653 +name: allantoin racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)(+)-allantoin = (R)(-)-allantoin." [EC:5.1.99.3, MetaCyc:ALLANTOIN-RACEMASE-RXN] +xref: EC:5.1.99.3 +xref: MetaCyc:ALLANTOIN-RACEMASE-RXN +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0047654 +name: alliin lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN] +synonym: "alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] +synonym: "alliin alkyl-sulfenate-lyase activity" EXACT [EC:4.4.1.4] +synonym: "alliinase activity" EXACT [EC:4.4.1.4] +synonym: "cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] +synonym: "cysteine sulphoxide lyase activity" EXACT [EC:4.4.1.4] +synonym: "L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] +synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" EXACT [EC:4.4.1.4] +synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4] +xref: EC:4.4.1.4 +xref: MetaCyc:ALLIIN-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047655 +name: allyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + NADPH." [EC:1.1.1.54, MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN] +synonym: "allyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.54] +xref: EC:1.1.1.54 +xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047656 +name: alpha,alpha-trehalose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHA\,ALPHA-TREHALOSE-PHOSPHORYLASE-RXN] +subset: gosubset_prok +synonym: "a,a-trehalose phosphorylase activity" EXACT [] +synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.64] +synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64] +xref: EC:2.4.1.64 +xref: MetaCyc:ALPHA\,ALPHA-TREHALOSE-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0047657 +name: alpha-1,3-glucan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-1\,3-GLUCAN-SYNTHASE-RXN] +synonym: "1,3-alpha-D-glucan synthase activity" EXACT [EC:2.4.1.183] +synonym: "1,3-alpha-glucan synthase activity" EXACT [] +synonym: "a-1,3-glucan synthase activity" EXACT [] +synonym: "UDP-glucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] +synonym: "UDPglucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183] +synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183] +xref: EC:2.4.1.183 +xref: MetaCyc:ALPHA-1\,3-GLUCAN-SYNTHASE-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047658 +name: alpha-amino-acid esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN] +subset: gosubset_prok +synonym: "a-amino-acid esterase activity" EXACT [] +synonym: "alpha-amino acid ester hydrolase activity" EXACT [EC:3.1.1.43] +synonym: "alpha-amino-acid ester hydrolase activity" EXACT [EC:3.1.1.43] +synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43] +xref: EC:3.1.1.43 +xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047659 +name: alpha-santonin 1,2-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-1\,2-REDUCTASE-RXN] +synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.47] +synonym: "a-santonin 1,2-reductase activity" EXACT [] +xref: EC:1.3.1.47 +xref: MetaCyc:ALPHA-SANTONIN-1\,2-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047660 +name: amidinoaspartase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea." [EC:3.5.3.14, MetaCyc:AMIDINOASPARTASE-RXN] +synonym: "amidinoaspartic amidinohydrolase activity" EXACT [EC:3.5.3.14] +synonym: "N-amidino-L-aspartate amidinohydrolase activity" EXACT [EC:3.5.3.14] +xref: EC:3.5.3.14 +xref: MetaCyc:AMIDINOASPARTASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047661 +name: amino-acid racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN] +subset: gosubset_prok +synonym: "L-amino acid racemase activity" EXACT [EC:5.1.1.10] +xref: EC:5.1.1.10 +xref: MetaCyc:AMINO-ACID-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047662 +name: aminobenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN] +synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24] +synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24] +xref: EC:4.1.1.24 +xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047663 +name: aminoglycoside 6'-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 6'-N-acetylaminoglycoside. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [GOC:cb] +subset: gosubset_prok +synonym: "6'-aminoglycoside-N-acetyltransferase activity" EXACT [EC:2.3.1.82] +synonym: "AAC(6') activity" RELATED [EC:2.3.1.82] +synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82] +synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT [] +synonym: "aminoglycoside-6'-acetyltransferase activity" EXACT [EC:2.3.1.82] +synonym: "aminoglycoside-6-N-acetyltransferase activity" EXACT [EC:2.3.1.82] +synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW [] +xref: EC:2.3.1.82 +xref: MetaCyc:AMINOGLYCOSIDE-N6'-ACETYLTRANSFERASE-RXN +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0047664 +name: aminoimidazolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminoimidazole + H2O = unidentified product + NH3." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN] +synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8] +synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8] +xref: EC:3.5.4.8 +xref: MetaCyc:AMINOIMIDAZOLASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0047665 +name: aminolevulinate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN] +synonym: "4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "4,5-dioxovaleric acid aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] +synonym: "4,5-dioxovaleric transaminase activity" EXACT [EC:2.6.1.43] +synonym: "5-aminolevulinate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "5-aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] +synonym: "alanine-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "alanine:4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "aminolevulinate aminotransferase activity" EXACT [] +synonym: "aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43] +synonym: "dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] +synonym: "DOVA transaminase activity" EXACT [EC:2.6.1.43] +synonym: "gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "gamma,delta-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] +synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43] +synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43] +synonym: "L-alanine:dioxovalerate transaminase activity" EXACT [EC:2.6.1.43] +xref: EC:2.6.1.43 +xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047666 +name: ammonia kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NH3 = ADP + phosphoramide." [EC:2.7.3.8, MetaCyc:AMMONIA-KINASE-RXN] +synonym: "ATP:ammonia phosphotransferase activity" EXACT [EC:2.7.3.8] +synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" EXACT [EC:2.7.3.8] +synonym: "phosphoramidate-ADP-phosphotransferase activity" EXACT [EC:2.7.3.8] +xref: EC:2.7.3.8 +xref: MetaCyc:AMMONIA-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047667 +name: AMP-thymidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN] +synonym: "adenylate-nucleoside phosphotransferase activity" EXACT [EC:2.7.1.114] +synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] +synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] +synonym: "AMP:deoxythymidine kinase activity" EXACT [EC:2.7.1.114] +synonym: "AMP:dThd kinase activity" EXACT [EC:2.7.1.114] +synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114] +synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114] +xref: EC:2.7.1.114 +xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047668 +name: amygdalin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose." [EC:3.2.1.117, MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN] +synonym: "amygdalin b-glucosidase activity" EXACT [] +synonym: "amygdalin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.117] +synonym: "amygdalin glucosidase activity" EXACT [EC:3.2.1.117] +synonym: "amygdalin hydrolase activity" EXACT [EC:3.2.1.117] +synonym: "amygdalinase" BROAD [EC:3.2.1.117] +xref: EC:3.2.1.117 +xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047669 +name: amylosucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN] +subset: gosubset_prok +synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] +synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4] +synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4] +xref: EC:2.4.1.4 +xref: MetaCyc:AMYLOSUCRASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047670 +name: anhydrotetracycline monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: anhydrotetracycline + NADPH + O2 = 12-dehydrotetracycline + NADP+ + H2O." [EC:1.14.13.38, MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN] +synonym: "anhydrotetracycline oxygenase activity" EXACT [EC:1.14.13.38] +synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.38] +synonym: "ATC oxygenase activity" EXACT [EC:1.14.13.38] +xref: EC:1.14.13.38 +xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047671 +name: anthranilate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + anthranilate = diphosphate + N-adenylylanthranilate." [EC:2.7.7.55, MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN] +synonym: "anthranilic acid adenylyltransferase activity" EXACT [EC:2.7.7.55] +synonym: "ATP:anthranilate adenylyltransferase activity" EXACT [] +synonym: "ATP:anthranilate N-adenylyltransferase activity" EXACT [EC:2.7.7.55] +xref: EC:2.7.7.55 +xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047672 +name: anthranilate N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + anthranilate = CoA + N-benzoylanthranilate." [EC:2.3.1.144, MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN] +synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144] +xref: EC:2.3.1.144 +xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047673 +name: anthranilate N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + anthranilate = CoA + N-malonylanthranilate." [EC:2.3.1.113, MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN] +synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" EXACT [EC:2.3.1.113] +xref: EC:2.3.1.113 +xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN +is_a: GO:0050735 ! N-malonyltransferase activity + +[Term] +id: GO:0047674 +name: apiose 1-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + NADH." [EC:1.1.1.114, MetaCyc:APIOSE-1-REDUCTASE-RXN] +synonym: "D-apiitol reductase activity" EXACT [EC:1.1.1.114] +synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.114] +synonym: "D-apiose reductase activity" EXACT [EC:1.1.1.114] +xref: EC:1.1.1.114 +xref: MetaCyc:APIOSE-1-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047675 +name: arabinonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O." [EC:4.2.1.5, MetaCyc:ARABINONATE-DEHYDRATASE-RXN] +synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" EXACT [EC:4.2.1.5] +synonym: "D-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.5] +xref: EC:4.2.1.5 +xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047676 +name: arachidonate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA." [EC:6.2.1.15, MetaCyc:ARACHIDONATE--COA-LIGASE-RXN] +synonym: "arachidonate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.15] +synonym: "arachidonoyl-CoA synthetase activity" EXACT [EC:6.2.1.15] +xref: EC:6.2.1.15 +xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047677 +name: arachidonate 8-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN] +synonym: "8(R)-lipoxygenase activity" EXACT [EC:1.13.11.40] +synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40] +synonym: "arachidonate:oxygen 8-oxidoreductase activity" EXACT [EC:1.13.11.40] +xref: EC:1.13.11.40 +xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047678 +name: arginine 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O." [EC:1.13.12.1, MetaCyc:ARGININE-2-MONOOXYGENASE-RXN] +synonym: "arginine decarboxy-oxidase activity" EXACT [EC:1.13.12.1] +synonym: "arginine monooxygenase activity" EXACT [EC:1.13.12.1] +synonym: "arginine oxygenase (decarboxylating) activity" EXACT [EC:1.13.12.1] +synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.1] +xref: EC:1.13.12.1 +xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0047679 +name: arginine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN] +xref: EC:5.1.1.9 +xref: MetaCyc:ARGININE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047680 +name: aryl-acylamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an anilide + H2O = a carboxylate + aniline." [EC:3.5.1.13, MetaCyc:ARYL-ACYLAMIDASE-RXN] +subset: gosubset_prok +synonym: "AAA-1" RELATED [EC:3.5.1.13] +synonym: "AAA-2" RELATED [EC:3.5.1.13] +synonym: "aryl-acylamide amidohydrolase activity" EXACT [EC:3.5.1.13] +synonym: "brain acetylcholinesterase (is associated with AAA-2)" EXACT [EC:3.5.1.13] +synonym: "pseudocholinesterase (associated with arylacylamidase)" EXACT [EC:3.5.1.13] +xref: EC:3.5.1.13 +xref: MetaCyc:ARYL-ACYLAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047681 +name: aryl-alcohol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-(NADP+)-RXN] +synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.91] +synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91] +synonym: "coniferyl alcohol dehydrogenase" BROAD [EC:1.1.1.91] +synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91] +xref: EC:1.1.1.91 +xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047682 +name: aryl-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN] +synonym: "arom. alcohol oxidase activity" EXACT [EC:1.1.3.7] +synonym: "aryl alcohol oxidase activity" EXACT [EC:1.1.3.7] +synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7] +synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7] +xref: EC:1.1.3.7 +xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047683 +name: aryl-aldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-(NADP+)-RXN] +synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30] +synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30] +xref: EC:1.2.1.30 +xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047684 +name: arylamine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP glucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] +synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] +synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71] +synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71] +xref: EC:2.4.1.71 +xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047685 +name: amine sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] +synonym: "amine N-sulfotransferase activity" EXACT [EC:2.8.2.3] +synonym: "amine sulphotransferase activity" EXACT [] +synonym: "arylamine sulfotransferase activity" EXACT [] +xref: EC:2.8.2.3 +xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047686 +name: arylsulfate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "arylsulfate-phenol sulfotransferase activity" EXACT [EC:2.8.2.22] +synonym: "arylsulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.22] +synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22] +synonym: "arylsulphate sulphotransferase activity" EXACT [] +synonym: "ASST" RELATED [EC:2.8.2.22] +xref: EC:2.8.2.22 +xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047687 +name: ascorbate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + O2 + ascorbate = L-threonate + oxalate." [EC:1.13.11.13, MetaCyc:ASCORBATE-2\,3-DIOXYGENASE-RXN] +synonym: "AAoxygenase activity" EXACT [EC:1.13.11.13] +synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [EC:1.13.11.13] +xref: EC:1.13.11.13 +xref: MetaCyc:ASCORBATE-2\,3-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047688 +name: aspartate 4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN] +subset: gosubset_prok +synonym: "aminomalonic decarboxylase activity" EXACT [EC:4.1.1.12] +synonym: "aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] +synonym: "aspartate omega-decarboxylase activity" EXACT [EC:4.1.1.12] +synonym: "aspartic beta-decarboxylase activity" EXACT [EC:4.1.1.12] +synonym: "aspartic omega-decarboxylase activity" EXACT [EC:4.1.1.12] +synonym: "cysteine sulfinic desulfinase activity" EXACT [EC:4.1.1.12] +synonym: "desulfinase activity" EXACT [EC:4.1.1.12] +synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" EXACT [EC:4.1.1.12] +synonym: "L-aspartate 4-carboxy-lyase activity" EXACT [EC:4.1.1.12] +synonym: "L-aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12] +synonym: "L-cysteine sulfinate acid desulfinase activity" EXACT [EC:4.1.1.12] +xref: EC:4.1.1.12 +xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047689 +name: aspartate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, MetaCyc:ASPARTATE-RACEMASE-RXN] +subset: gosubset_prok +synonym: "D-aspartate racemase activity" EXACT [EC:5.1.1.13] +xref: EC:5.1.1.13 +xref: MetaCyc:ASPARTATE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047690 +name: aspartyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine + hydroxylamine = NH3 + L-aspartylhydroxamate." [EC:2.3.2.7, MetaCyc:ASPARTYLTRANSFERASE-RXN] +synonym: "aspartotransferase activity" EXACT [EC:2.3.2.7] +synonym: "beta-aspartyl transferase activity" EXACT [EC:2.3.2.7] +synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" EXACT [EC:2.3.2.7] +xref: EC:2.3.2.7 +xref: MetaCyc:ASPARTYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0047691 +name: aspulvinone dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 dimethylallyl diphosphate + aspulvinone E = 2 diphosphate + aspulvinone H." [EC:2.5.1.35, MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN] +synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" EXACT [EC:2.5.1.35] +synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" EXACT [EC:2.5.1.35] +xref: EC:2.5.1.35 +xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047692 +name: ATP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN] +synonym: "adenosine triphosphate deaminase activity" EXACT [EC:3.5.4.18] +synonym: "ATP aminohydrolase activity" EXACT [EC:3.5.4.18] +xref: EC:3.5.4.18 +xref: MetaCyc:ATP-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047693 +name: ATP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [EC:3.6.1.8, MetaCyc:ATP-PYROPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8] +synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8] +synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8] +synonym: "ATP pyrophosphatase activity" EXACT [] +xref: EC:3.6.1.8 +xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0047694 +name: barbiturase activity +namespace: molecular_function +def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN] +synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" EXACT [EC:3.5.2.1] +xref: EC:3.5.2.1 +xref: MetaCyc:BARBITURASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047695 +name: benzoin aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, MetaCyc:BENZOIN-ALDOLASE-RXN] +subset: gosubset_prok +synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" EXACT [EC:4.1.2.38] +synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" EXACT [EC:4.1.2.38] +synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] +synonym: "benzaldehyde lyase activity" EXACT [EC:4.1.2.38] +synonym: "diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38] +xref: EC:4.1.2.38 +xref: MetaCyc:BENZOIN-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047696 +name: beta-adrenergic receptor kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN] +synonym: "[b-adrenergic-receptor] kinase activity" EXACT [EC:2.7.11.15] +synonym: "ADRBK1" RELATED [EC:2.7.11.15] +synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15] +synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15] +synonym: "BARK1" RELATED [EC:2.7.11.15] +synonym: "beta-adrenergic receptor-specific kinase activity" EXACT [EC:2.7.11.15] +synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.15] +synonym: "beta-adrenergic-receptor kinase activity" EXACT [EC:2.7.11.15] +synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15] +synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15] +synonym: "beta-adrenoceptor kinase activity" EXACT [EC:2.7.11.15] +synonym: "beta-AR kinase activity" EXACT [EC:2.7.11.15] +synonym: "beta-ARK" RELATED [EC:2.7.11.15] +synonym: "beta-ARK 1" RELATED [EC:2.7.11.15] +synonym: "beta-ARK 2" RELATED [EC:2.7.11.15] +synonym: "beta-receptor kinase activity" EXACT [EC:2.7.11.15] +synonym: "beta2ARK" RELATED [EC:2.7.11.15] +synonym: "betaARK1" RELATED [EC:2.7.11.15] +synonym: "GRK2" RELATED [EC:2.7.11.15] +synonym: "GRK3" RELATED [EC:2.7.11.15] +synonym: "STK15" RELATED [EC:2.7.11.15] +xref: EC:2.7.11.15 +xref: MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047697 +name: beta-alanopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH." [EC:1.5.1.26, MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN] +synonym: "b-alanopine dehydrogenase activity" EXACT [] +synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" EXACT [EC:1.5.1.26] +xref: EC:1.5.1.26 +xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047698 +name: beta-alanyl-CoA ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN] +synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT [] +synonym: "beta-alanyl coenzyme A ammonia-lyase activity" EXACT [EC:4.3.1.6] +synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" EXACT [EC:4.3.1.6] +xref: EC:4.3.1.6 +xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047699 +name: beta-diketone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: nonane-4,6-dione + H2O = pentan-2-one + butanoate." [EC:3.7.1.7, MetaCyc:BETA-DIKETONE-HYDROLASE-RXN] +synonym: "b-diketone hydrolase activity" EXACT [] +synonym: "nonane-4,6-dione acylhydrolase activity" EXACT [EC:3.7.1.7] +synonym: "oxidized PVA hydrolase activity" EXACT [EC:3.7.1.7] +xref: EC:3.7.1.7 +xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0047700 +name: beta-glucoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN] +subset: gosubset_prok +synonym: "ATP:cellobiose 6-phosphotransferase activity" EXACT [EC:2.7.1.85] +synonym: "b-glucoside kinase activity" EXACT [] +synonym: "beta-D-glucoside kinase (phosphorylating)" EXACT [EC:2.7.1.85] +xref: EC:2.7.1.85 +xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047701 +name: beta-L-arabinosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN] +synonym: "b-L-arabinosidase activity" EXACT [] +synonym: "beta-L-arabinoside arabinohydrolase activity" EXACT [EC:3.2.1.88] +synonym: "vicianosidase activity" EXACT [EC:3.2.1.88] +xref: EC:3.2.1.88 +xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047702 +name: beta-lysine 5,6-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, MetaCyc:BETA-LYSINE-5\,6-AMINOMUTASE-RXN] +subset: gosubset_prok +synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.3] +synonym: "b-lysine 5,6-aminomutase activity" EXACT [] +synonym: "beta-lysine mutase activity" EXACT [EC:5.4.3.3] +synonym: "L-beta-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.3] +xref: EC:5.4.3.3 +xref: MetaCyc:BETA-LYSINE-5\,6-AMINOMUTASE-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0047703 +name: beta-nitroacrylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + NADPH." [EC:1.3.1.16, MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN] +synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.16] +synonym: "b-nitroacrylate reductase activity" EXACT [] +xref: EC:1.3.1.16 +xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047704 +name: bile-salt sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14] +synonym: "BAST I activity" NARROW [EC:2.8.2.14] +synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] +synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14] +synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14] +synonym: "bile-salt sulphotransferase activity" EXACT [] +synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] +xref: EC:2.8.2.14 +xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047705 +name: bilirubin oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O." [EC:1.3.3.5, MetaCyc:BILIRUBIN-OXIDASE-RXN] +synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5] +synonym: "bilirubin:oxygen oxidoreductase activity" EXACT [EC:1.3.3.5] +xref: EC:1.3.3.5 +xref: MetaCyc:BILIRUBIN-OXIDASE-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0047706 +name: biochanin-A reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + NADPH." [EC:1.3.1.46, MetaCyc:BIOCHANIN-A-REDUCTASE-RXN] +synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.46] +xref: EC:1.3.1.46 +xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047707 +name: biotin-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN] +synonym: "biotin CoA synthetase activity" EXACT [EC:6.2.1.11] +synonym: "biotin:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.11] +synonym: "biotinyl coenzyme A synthetase activity" EXACT [EC:6.2.1.11] +synonym: "biotinyl-CoA synthetase activity" EXACT [EC:6.2.1.11] +xref: EC:6.2.1.11 +xref: MetaCyc:BIOTIN--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047708 +name: biotinidase activity +namespace: molecular_function +def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN] +synonym: "amidohydrolase biotinidase activity" EXACT [EC:3.5.1.12] +synonym: "biotin-amide amidohydrolase activity" EXACT [EC:3.5.1.12] +xref: EC:3.5.1.12 +xref: MetaCyc:BIOTINIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047709 +name: bis(2-ethylhexyl)phthalate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexyl phthalate + 2-ethylhexan-1-ol." [EC:3.1.1.60, MetaCyc:BIS(2-ETHYLHEXYL)PHTHALATE-ESTERASE-RXN] +synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" EXACT [EC:3.1.1.60] +synonym: "DEHP esterase activity" EXACT [EC:3.1.1.60] +xref: EC:3.1.1.60 +xref: MetaCyc:BIS(2-ETHYLHEXYL)PHTHALATE-ESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047710 +name: bis(5'-adenosyl)-triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP." [EC:3.6.1.29, MetaCyc:BIS(5'-ADENOSYL)-TRIPHOSPHATASE-RXN] +synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] +synonym: "AP(3)A hydrolase activity" EXACT [EC:3.6.1.29] +synonym: "AP(3)Aase activity" EXACT [EC:3.6.1.29] +synonym: "AP3A hydrolase activity" EXACT [EC:3.6.1.29] +synonym: "AP3Aase activity" EXACT [EC:3.6.1.29] +synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] +synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" EXACT [EC:3.6.1.29] +synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" EXACT [EC:3.6.1.29] +synonym: "dinucleosidetriphosphatase activity" EXACT [EC:3.6.1.29] +synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29] +xref: EC:3.6.1.29 +xref: MetaCyc:BIS(5'-ADENOSYL)-TRIPHOSPHATASE-RXN +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0047711 +name: blasticidin-S deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN] +subset: gosubset_prok +synonym: "blasticidin-S aminohydrolase activity" EXACT [EC:3.5.4.23] +xref: EC:3.5.4.23 +xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047712 +name: Cypridina-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] +synonym: "Cypridina luciferase activity" EXACT [EC:1.13.12.6] +synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.6] +synonym: "Cypridina-type luciferase activity" EXACT [EC:1.13.12.6] +synonym: "cypridina-type luciferase activity" EXACT [EC:1.13.12.6] +synonym: "luciferase (Cypridina luciferin)" EXACT [EC:1.13.12.6] +synonym: "luciferase activity" BROAD [EC:1.13.12.6] +xref: EC:1.13.12.6 +xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0047713 +name: galactitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactitol + NAD+ = D-tagatose + NADH." [EC:1.1.1.16, MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN] +xref: EC:1.1.1.16 +xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0047714 +name: galactolipase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN] +synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" EXACT [EC:3.1.1.26] +synonym: "galactolipid acylhydrolase activity" EXACT [EC:3.1.1.26] +synonym: "galactolipid lipase activity" EXACT [EC:3.1.1.26] +synonym: "polygalactolipase activity" EXACT [EC:3.1.1.26] +xref: EC:3.1.1.26 +xref: MetaCyc:GALACTOLIPASE-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0016298 ! lipase activity + +[Term] +id: GO:0047715 +name: hypotaurocyamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: hypotaurocyamine + ATP = N(omega)-phosphohypotaurocyamine + ADP." [EC:2.7.3.6, MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN] +synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.6] +xref: EC:2.7.3.6 +xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047716 +name: imidazole N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + imidazole = CoA + N-acetylimidazole." [EC:2.3.1.2, MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" EXACT [EC:2.3.1.2] +synonym: "imidazole acetylase activity" EXACT [EC:2.3.1.2] +synonym: "imidazole acetyltransferase activity" EXACT [EC:2.3.1.2] +xref: EC:2.3.1.2 +xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047717 +name: imidazoleacetate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-imidazoleacetate + NADH + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O." [EC:1.14.13.5, MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN] +synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.13.5] +synonym: "imidazoleacetate hydroxylase activity" EXACT [EC:1.14.13.5] +synonym: "imidazoleacetic hydroxylase activity" EXACT [] +synonym: "imidazoleacetic monooxygenase activity" EXACT [EC:1.14.13.5] +xref: EC:1.14.13.5 +xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047718 +name: indanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN] +synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.112] +xref: EC:1.1.1.112 +xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047719 +name: indole 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole + O2 = 2-formylaminobenzaldehyde." [EC:1.13.11.17, MetaCyc:INDOLE-2\,3-DIOXYGENASE-RXN] +synonym: "IDO" RELATED [EC:1.13.11.17] +synonym: "indole oxidase activity" EXACT [EC:1.13.11.17] +synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] +synonym: "indole:O2 oxidoreductase activity" EXACT [EC:1.13.11.17] +synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17] +xref: EC:1.13.11.17 +xref: MetaCyc:INDOLE-2\,3-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047720 +name: indoleacetaldoxime dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetaldoxime = indole-3-acetonitrile + H2O." [EC:4.2.1.29, MetaCyc:INDOLEACETALDOXIME-DEHYDRATASE-RXN] +synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6] +synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] +synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] +synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6] +synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] +synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6] +xref: EC:4.99.1.6 +xref: MetaCyc:RXN-1403 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0047721 +name: indoleacetate-lysine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + indoleacetate + L-lysine = ADP + phosphate + N6-[(indole-3-yl)acetyl]-L-lysine." [EC:6.3.2.20, MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN] +subset: gosubset_prok +synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] +synonym: "IAA-lysine synthetase activity" EXACT [EC:6.3.2.20] +synonym: "indoleacetate-lysine ligase activity" EXACT [] +synonym: "indoleacetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20] +synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" EXACT [EC:6.3.2.20] +xref: EC:6.3.2.20 +xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047722 +name: indolelactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indolelactate + NAD+ = indolepyruvate + NADH." [EC:1.1.1.110, MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN] +synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] +synonym: "indole-3-lactate dehydrogenase activity" EXACT [] +synonym: "indolelactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110] +xref: EC:1.1.1.110 +xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047723 +name: inosinate nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-inosinate + H2O = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, MetaCyc:INOSINATE-NUCLEOSIDASE-RXN] +synonym: "5'-inosinate phosphoribohydrolase activity" EXACT [EC:3.2.2.12] +xref: EC:3.2.2.12 +xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047724 +name: inosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN] +synonym: "inosinase activity" EXACT [EC:3.2.2.2] +synonym: "inosine ribohydrolase activity" EXACT [EC:3.2.2.2] +synonym: "inosine-guanosine nucleosidase activity" EXACT [EC:3.2.2.2] +xref: EC:3.2.2.2 +xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047725 +name: inulosucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN] +subset: gosubset_prok +synonym: "sucrose 1-fructosyl transferase activity" EXACT [EC:2.4.1.9] +synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9] +synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9] +xref: EC:2.4.1.9 +xref: MetaCyc:INULOSUCRASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047726 +name: iron-cytochrome-c reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.99.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN] +synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" EXACT [EC:1.9.99.1] +synonym: "iron-cytochrome c reductase activity" EXACT [EC:1.9.99.1] +xref: EC:1.9.99.1 +xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN +is_a: GO:0016675 ! oxidoreductase activity, acting on heme group of donors + +[Term] +id: GO:0047727 +name: isobutyryl-CoA mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylpropanoyl-CoA = butanoyl-CoA." [EC:5.4.99.13, MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN] +subset: gosubset_prok +synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.13] +synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" EXACT [EC:5.4.99.13] +synonym: "isobutyryl coenzyme A mutase activity" EXACT [EC:5.4.99.13] +xref: EC:5.4.99.13 +xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047728 +name: carnitine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + L-carnitine = NADH + 3-dehydrocarnitine." [EC:1.1.1.108, MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "carnitine:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.108] +xref: EC:1.1.1.108 +xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047729 +name: carnitine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: carnitine = 2-methylcholine + CO2." [EC:4.1.1.42, MetaCyc:CARNITINE-DECARBOXYLASE-RXN] +synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" EXACT [EC:4.1.1.42] +synonym: "carnitine carboxy-lyase activity" EXACT [EC:4.1.1.42] +xref: EC:4.1.1.42 +xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047730 +name: carnosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN] +synonym: "carnosine synthetase activity" EXACT [EC:6.3.2.11] +synonym: "carnosine-anserine synthetase activity" EXACT [EC:6.3.2.11] +synonym: "carnosine-homocarnosine synthetase activity" EXACT [EC:6.3.2.11] +synonym: "homocarnosine-carnosine synthetase activity" EXACT [EC:6.3.2.11] +synonym: "L-histidine:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.11] +xref: EC:6.3.2.11 +xref: MetaCyc:CARNOSINE-SYNTHASE-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047731 +name: catechol oxidase (dimerizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-(DIMERIZING)-RXN] +synonym: "catechol:oxygen oxidoreductase (dimerizing)" EXACT [EC:1.1.3.14] +xref: EC:1.1.3.14 +xref: MetaCyc:CATECHOL-OXIDASE-(DIMERIZING)-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047732 +name: CDP-abequose epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, MetaCyc:CDP-ABEQUOSE-EPIMERASE-RXN] +synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" EXACT [EC:5.1.3.10] +synonym: "CDP-D-abequose 2-epimerase activity" EXACT [EC:5.1.3.10] +synonym: "CDP-paratose 2-epimerase activity" EXACT [EC:5.1.3.10] +synonym: "CDP-paratose epimerase activity" EXACT [EC:5.1.3.10] +synonym: "CDP-tyvelose 2-epimerase activity" EXACT [EC:5.1.3.10] +synonym: "cytidine diphosphate paratose-2-epimerase activity" EXACT [EC:5.1.3.10] +synonym: "cytidine diphosphoabequose epimerase activity" EXACT [EC:5.1.3.10] +synonym: "cytidine diphosphodideoxyglucose epimerase activity" EXACT [EC:5.1.3.10] +synonym: "cytidine diphosphoparatose epimerase activity" EXACT [EC:5.1.3.10] +xref: EC:5.1.3.10 +xref: MetaCyc:CDP-ABEQUOSE-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047733 +name: CDP-glucose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.45, MetaCyc:CDP-GLUCOSE-4\,6-DEHYDRATASE-RXN] +subset: gosubset_prok +synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.45] +synonym: "CDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] +synonym: "CDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.45] +synonym: "CDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45] +synonym: "cytidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.45] +xref: EC:4.2.1.45 +xref: MetaCyc:CDP-GLUCOSE-4\,6-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047734 +name: CDP-glycerol diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate." [EC:3.6.1.16, MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN] +synonym: "CDP-glycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] +synonym: "CDP-glycerol pyrophosphatase activity" EXACT [] +synonym: "CDPglycerol diphosphatase activity" EXACT [EC:3.6.1.16] +synonym: "CDPglycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16] +synonym: "CDPglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] +synonym: "cytidine diphosphoglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16] +xref: EC:3.6.1.16 +xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047735 +name: cellobiose dehydrogenase (acceptor) activity +namespace: molecular_function +alt_id: GO:0047737 +def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-(ACCEPTOR)-RXN] +synonym: "CBOR activity" RELATED [EC:1.1.99.18] +synonym: "CDH activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18] +synonym: "cellobiose dehydrogenase activity" EXACT [EC:1.1.99.18] +synonym: "cellobiose oxidase activity" EXACT [EC:1.1.99.18] +synonym: "cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] +synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18] +synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.18] +synonym: "cellobiose:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.18] +synonym: "cellobiose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.99.18] +synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18] +xref: EC:1.1.99.18 +xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-(ACCEPTOR)-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047736 +name: cellobiose epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN] +synonym: "cellobiose 2-epimerase activity" EXACT [EC:5.1.3.11] +xref: EC:5.1.3.11 +xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047738 +name: cellobiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN] +subset: gosubset_prok +synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.20] +xref: EC:2.4.1.20 +xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0047739 +name: cephalosporin-C deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cephalosporin C + H2O = deacetylcephalosporin C + acetate." [EC:3.1.1.41, MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN] +subset: gosubset_prok +synonym: "cephalosporin acetylesterase activity" EXACT [EC:3.1.1.41] +synonym: "cephalosporin C acetyl-esterase activity" EXACT [EC:3.1.1.41] +synonym: "cephalosporin C acetyl-hydrolase activity" EXACT [EC:3.1.1.41] +synonym: "cephalosporin C acetylase activity" EXACT [EC:3.1.1.41] +synonym: "cephalosporin C acetylesterase activity" EXACT [EC:3.1.1.41] +synonym: "cephalosporin C deacetylase activity" EXACT [EC:3.1.1.41] +synonym: "cephalosporin-C acetylhydrolase activity" EXACT [EC:3.1.1.41] +xref: EC:3.1.1.41 +xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047740 +name: cephalosporin-C transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cephalosporin C + pyruvate = 7-(5-carboxyl-5-oxopentanyl)-aminocephalosporinate + L-alanine." [EC:2.6.1.74, MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN] +synonym: "cephalosporin C aminotransferase activity" EXACT [EC:2.6.1.74] +synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.74] +synonym: "L-alanine:cephalosporin-C aminotransferase activity" EXACT [EC:2.6.1.74] +xref: EC:2.6.1.74 +xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047741 +name: cetraxate benzylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: cetraxate benzyl ester + H2O = cetraxate + benzyl alcohol." [EC:3.1.1.70, MetaCyc:CETRAXATE-BENZYLESTERASE-RXN] +synonym: "cetraxate-benzyl-ester benzylhydrolase activity" EXACT [EC:3.1.1.70] +xref: EC:3.1.1.70 +xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047742 +name: chenodeoxycholoyltaurine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN] +synonym: "chenodeoxycholoyltaurine amidohydrolase activity" EXACT [EC:3.5.1.74] +xref: EC:3.5.1.74 +xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047743 +name: chlordecone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + NADPH." [EC:1.1.1.225, MetaCyc:CHLORDECONE-REDUCTASE-RXN] +synonym: "CDR activity" RELATED [EC:1.1.1.225] +synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.225] +xref: EC:1.1.1.225 +xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047744 +name: chloridazon-catechol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone." [EC:1.13.11.36, MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN] +synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.36] +xref: EC:1.13.11.36 +xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047745 +name: chlorogenate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorogenate + H2O = caffeate + quinate." [EC:3.1.1.42, MetaCyc:CHLOROGENATE-HYDROLASE-RXN] +synonym: "chlorogenase activity" EXACT [EC:3.1.1.42] +synonym: "chlorogenic acid esterase activity" EXACT [EC:3.1.1.42] +xref: EC:3.1.1.42 +xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047746 +name: chlorophyllase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN] +synonym: "chlorophyll chlorophyllidohydrolase activity" EXACT [EC:3.1.1.14] +xref: EC:3.1.1.14 +xref: MetaCyc:CHLOROPHYLLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047747 +name: cholate-CoA ligase activity +namespace: molecular_function +alt_id: GO:0047477 +def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" EXACT [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT [] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] +synonym: "BAL activity" RELATED [EC:6.2.1.29] +synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29] +synonym: "cholate thiokinase activity" EXACT [EC:6.2.1.29] +synonym: "cholate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29] +synonym: "cholic acid:CoA ligase activity" EXACT [EC:6.2.1.29] +synonym: "cholic thiokinase activity" EXACT [EC:6.2.1.29] +synonym: "choloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29] +synonym: "choloyl-CoA synthetase activity" EXACT [EC:6.2.1.29] +synonym: "cholyl-CoA synthetase activity" EXACT [EC:6.2.1.29] +synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29] +xref: EC:6.2.1.29 +xref: EC:6.2.1.7 +xref: MetaCyc:6.2.1.29-RXN +xref: MetaCyc:CHOLATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047748 +name: cholestanetetraol 26-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [EC:1.1.1.161, MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [EC:1.1.1.161] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [EC:1.1.1.161] +synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [EC:1.1.1.161] +synonym: "TEHC-NAD oxidoreductase activity" EXACT [EC:1.1.1.161] +xref: EC:1.1.1.161 +xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047749 +name: cholestanetriol 26-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.13.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN] +synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15] +synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.13.15] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" EXACT [EC:1.14.13.15] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" EXACT [EC:1.14.13.15] +synonym: "cholestanetriol 26-hydroxylase activity" EXACT [] +synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.13.15] +synonym: "CYP27A" RELATED [EC:1.14.13.15] +synonym: "CYP27A1" RELATED [EC:1.14.13.15] +synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.13.15] +synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.13.15] +synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.13.15] +xref: EC:1.14.13.15 +xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047750 +name: cholestenol delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN] +synonym: "cholestenol D-isomerase activity" EXACT [] +synonym: "delta7-cholestenol delta7-delta8-isomerase activity" EXACT [EC:5.3.3.5] +xref: EC:5.3.3.5 +xref: MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0047751 +name: cholestenone 5-alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH." [EC:1.3.1.22, MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN] +synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.22] +synonym: "3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] +synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22] +synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22] +synonym: "4-ene-5alpha-reductase activity" EXACT [EC:1.3.1.22] +synonym: "5alpha-reductase" BROAD [EC:1.3.1.22] +synonym: "cholest-4-en-3-one 5alpha-reductase activity" EXACT [EC:1.3.1.22] +synonym: "cholestenone 5a-reductase activity" EXACT [] +synonym: "cholestenone 5alpha-reductase activity" EXACT [EC:1.3.1.22] +synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] +synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22] +synonym: "steroid 5alpha-hydrogenase activity" EXACT [EC:1.3.1.22] +synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22] +synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22] +synonym: "testosterone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.22] +synonym: "testosterone delta4-hydrogenase activity" EXACT [EC:1.3.1.22] +xref: EC:1.3.1.22 +xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047753 +name: choline-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline sulfate + H2O = choline + sulfate." [EC:3.1.6.6, MetaCyc:CHOLINE-SULFATASE-RXN] +subset: gosubset_prok +synonym: "choline-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.6] +synonym: "choline-sulphatase activity" EXACT [] +xref: EC:3.1.6.6 +xref: MetaCyc:CHOLINE-SULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047754 +name: choline sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate." [EC:2.8.2.6, MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" EXACT [EC:2.8.2.6] +synonym: "choline sulphokinase activity" EXACT [EC:2.8.2.6] +synonym: "choline sulphotransferase activity" EXACT [] +xref: EC:2.8.2.6 +xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047755 +name: isocitrate epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate = (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate." [EC:5.1.2.6, MetaCyc:ISOCITRATE-EPIMERASE-RXN] +synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" EXACT [EC:5.1.2.6] +xref: EC:5.1.2.6 +xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0047756 +name: chondroitin 4-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" EXACT [EC:2.8.2.5] +synonym: "chondroitin 4-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.5 +xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN +is_a: GO:0034481 ! chondroitin sulfotransferase activity + +[Term] +id: GO:0047757 +name: chondroitin-glucuronate 5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN] +synonym: "chondroitin D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.19] +synonym: "chondroitin-D-glucuronate 5-epimerase activity" EXACT [EC:5.1.3.19] +synonym: "dermatan-sulfate 5-epimerase activity" EXACT [EC:5.1.3.19] +synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19] +synonym: "urunosyl C-5 epimerase activity" EXACT [EC:5.1.3.19] +xref: EC:5.1.3.19 +xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047758 +name: branched-chain fatty acid kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-methylpropanoate = ADP + 2-methylpropanoyl phosphate." [EC:2.7.2.14, MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN] +synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" EXACT [EC:2.7.2.14] +synonym: "branched-chain-fatty-acid kinase activity" EXACT [] +synonym: "isobutyrate kinase activity" NARROW [EC:2.7.2.14] +xref: EC:2.7.2.14 +xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047759 +name: butanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN] +synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.57] +xref: EC:1.2.1.57 +xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047760 +name: butyrate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN] +synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2] +synonym: "butanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.2] +synonym: "butyryl-CoA synthetase activity" EXACT [EC:6.2.1.2] +synonym: "butyryl-coenzyme A synthetase activity" EXACT [EC:6.2.1.2] +synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2] +synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2] +synonym: "fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.2] +synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" EXACT [EC:6.2.1.2] +synonym: "medium chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] +synonym: "short-chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2] +xref: EC:6.2.1.2 +xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047761 +name: butyrate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate." [EC:2.7.2.7, MetaCyc:BUTYRATE-KINASE-RXN] +subset: gosubset_prok +synonym: "ATP:butanoate 1-phosphotransferase activity" EXACT [EC:2.7.2.7] +xref: EC:2.7.2.7 +xref: MetaCyc:BUTYRATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047762 +name: caffeate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-trans-cinnamate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate." [EC:1.13.11.22, MetaCyc:CAFFEATE-3\,4-DIOXYGENASE-RXN] +synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.22] +xref: EC:1.13.11.22 +xref: MetaCyc:CAFFEATE-3\,4-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047763 +name: caffeate O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN] +synonym: "caffeate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] +synonym: "caffeate methyltransferase activity" EXACT [EC:2.1.1.68] +synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68] +synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" EXACT [EC:2.1.1.68] +xref: EC:2.1.1.68 +xref: MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0047764 +name: caldesmon kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators] +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047765 +name: caldesmon-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN] +synonym: "caldesmon-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.55] +synonym: "smooth muscle caldesmon phosphatase activity" EXACT [EC:3.1.3.55] +synonym: "SMP-I" RELATED [EC:3.1.3.55] +xref: EC:3.1.3.55 +xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047766 +name: carbamoyl-serine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2." [EC:4.3.1.13, MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN] +synonym: "carbamoylserine deaminase activity" EXACT [EC:4.3.1.13] +synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" EXACT [EC:4.3.1.13] +synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.13] +synonym: "O-carbamoyl-L-serine deaminase activity" EXACT [EC:4.3.1.13] +xref: EC:4.3.1.13 +xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047768 +name: carboxy-cis,cis-muconate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, MetaCyc:CARBOXY-CIS\,CIS-MUCONATE-CYCLASE-RXN] +synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.5] +synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" EXACT [EC:5.5.1.5] +synonym: "3-carboxymuconate cyclase activity" EXACT [EC:5.5.1.5] +xref: EC:5.5.1.5 +xref: MetaCyc:CARBOXY-CIS\,CIS-MUCONATE-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047769 +name: arogenate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN] +subset: gosubset_prok +synonym: "carboxycyclohexadienyl dehydratase activity" EXACT [] +synonym: "L-arogenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.91] +synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" EXACT [EC:4.2.1.91] +xref: EC:4.2.1.91 +xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047770 +name: carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN] +synonym: "aldehyde:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.6] +synonym: "aldehyde:acceptor oxidoreductase activity" EXACT [EC:1.2.99.6] +synonym: "carboxylic acid reductase activity" EXACT [EC:1.2.99.6] +xref: EC:1.2.99.6 +xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0047771 +name: carboxymethylhydantoinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.4, MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN] +synonym: "hydantoin hydrolase activity" EXACT [EC:3.5.2.4] +synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.4] +xref: EC:3.5.2.4 +xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047772 +name: carboxymethyloxysuccinate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2 carboxymethyloxysuccinate = 2 glycolate + 2 fumarate." [EC:4.2.99.12, MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN] +synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" EXACT [EC:4.2.99.12] +synonym: "carboxymethyloxysuccinate glycolate-lyase activity" EXACT [EC:4.2.99.12] +xref: EC:4.2.99.12 +xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0047773 +name: carnitinamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-carnitinamide + H2O = L-carnitine + NH3." [EC:3.5.1.73, MetaCyc:CARNITINAMIDASE-RXN] +synonym: "carnitine amidase activity" EXACT [EC:3.5.1.73] +synonym: "L-carnitinamidase activity" EXACT [EC:3.5.1.73] +synonym: "L-carnitinamide amidohydrolase activity" EXACT [EC:3.5.1.73] +synonym: "L-carnitine amidase activity" EXACT [EC:3.5.1.73] +xref: EC:3.5.1.73 +xref: MetaCyc:CARNITINAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047774 +name: cis-2-enoyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-(NADPH)-RXN] +synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" EXACT [EC:1.3.1.37] +synonym: "cis-2-enoyl-coenzyme A reductase activity" EXACT [EC:1.3.1.37] +synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" EXACT [EC:1.3.1.37] +synonym: "reductase, cis-2-enoyl coenzyme A" EXACT [EC:1.3.1.37] +xref: EC:1.3.1.37 +xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-(NADPH)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047775 +name: citramalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN] +synonym: "acetyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.11] +xref: EC:2.8.3.11 +xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047776 +name: citramalate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-citramalate = acetate + pyruvate." [EC:4.1.3.22, MetaCyc:CITRAMALATE-LYASE-RXN] +synonym: "(+)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] +synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" EXACT [EC:4.1.3.22] +synonym: "(3S)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] +synonym: "(S)-citramalate lyase activity" EXACT [EC:4.1.3.22] +synonym: "citramalate pyruvate lyase activity" EXACT [EC:4.1.3.22] +synonym: "citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22] +synonym: "citramalate synthetase activity" EXACT [EC:4.1.3.22] +synonym: "citramalic synthase activity" EXACT [EC:4.1.3.22] +synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22] +xref: EC:4.1.3.22 +xref: MetaCyc:CITRAMALATE-LYASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047777 +name: citramalyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, MetaCyc:CITRAMALYL-COA-LYASE-RXN] +synonym: "(+)-CMA-CoA lyase activity" EXACT [EC:4.1.3.25] +synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.25] +synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" EXACT [EC:4.1.3.25] +synonym: "citramalyl coenzyme A lyase activity" EXACT [EC:4.1.3.25] +xref: EC:4.1.3.25 +xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047778 +name: [citrate-(pro-3S)-lyase] thiolesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-(PRO-3S)-LYASE-THIOLESTERASE-RXN] +synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" EXACT [EC:3.1.2.16] +synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT [] +synonym: "citrate lyase deacetylase activity" EXACT [EC:3.1.2.16] +synonym: "citrate-(pro-3S)-lyase thioesterase activity" EXACT [EC:3.1.2.16] +synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16] +synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16] +xref: EC:3.1.2.16 +xref: MetaCyc:CITRATE-(PRO-3S)-LYASE-THIOLESTERASE-RXN +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0047779 +name: citrate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA." [EC:6.2.1.18, MetaCyc:CITRATE--COA-LIGASE-RXN] +synonym: "citrate thiokinase activity" EXACT [EC:6.2.1.18] +synonym: "citrate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.18] +synonym: "citrate:CoA ligase activity" EXACT [EC:6.2.1.18] +synonym: "citryl-CoA synthetase activity" EXACT [EC:6.2.1.18] +xref: EC:6.2.1.18 +xref: MetaCyc:CITRATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047780 +name: citrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.4, MetaCyc:CITRATE-DEHYDRATASE-RXN] +synonym: "citrate hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.4] +synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.4] +xref: EC:4.2.1.4 +xref: MetaCyc:CITRATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047781 +name: citrullinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN] +synonym: "citrulline hydrolase activity" EXACT [EC:3.5.1.20] +synonym: "citrulline ureidase activity" EXACT [EC:3.5.1.20] +synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] +synonym: "L-citrulline N5-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20] +xref: EC:3.5.1.20 +xref: MetaCyc:CITRULLINASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047782 +name: coniferin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN] +synonym: "coniferin b-glucosidase activity" EXACT [] +synonym: "coniferin beta-D-glucosidase activity" EXACT [EC:3.2.1.126] +synonym: "coniferin-hydrolyzing beta-glucosidase activity" EXACT [EC:3.2.1.126] +xref: EC:3.2.1.126 +xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047783 +name: corticosterone 18-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN] +synonym: "corticosterone 18-hydroxylase activity" EXACT [] +synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5] +synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5] +xref: EC:1.14.15.5 +xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047784 +name: cortisol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" EXACT [EC:2.3.1.27] +synonym: "corticosteroid acetyltransferase activity" EXACT [EC:2.3.1.27] +synonym: "corticosteroid-21-O-acetyltransferase activity" EXACT [EC:2.3.1.27] +synonym: "cortisol acetyltransferase activity" EXACT [EC:2.3.1.27] +xref: EC:2.3.1.27 +xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047785 +name: cortisol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate." [EC:2.8.2.18, MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" EXACT [EC:2.8.2.18] +synonym: "cortisol sulphotransferase activity" EXACT [] +synonym: "glucocorticoid sulfotransferase activity" EXACT [EC:2.8.2.18] +synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18] +xref: EC:2.8.2.18 +xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047786 +name: cortisone alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-alpha-dihydrocortisone + NADP+ = cortisone + NADPH." [EC:1.3.1.4, MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN] +synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.4] +synonym: "cortisone a-reductase activity" EXACT [] +synonym: "cortisone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] +synonym: "delta4-3-ketosteroid reductase (5alpha)" EXACT [EC:1.3.1.4] +synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.1.4] +synonym: "delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4] +synonym: "microsomal steroid reductase (5alpha)" EXACT [EC:1.3.1.4] +synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.1.4] +xref: EC:1.3.1.4 +xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047787 +name: delta4-3-oxosteroid 5beta-reductase activity +namespace: molecular_function +alt_id: GO:0047752 +def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN] +synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] +synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "3-oxo-delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23] +synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23] +synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" EXACT [EC:1.3.1.23] +synonym: "5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "androstenedione 5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "androstenedione 5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "cholestenone 5-beta-reductase activity" EXACT [] +synonym: "cholestenone 5b-reductase activity" EXACT [] +synonym: "cholestenone 5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "cortisone 5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "cortisone 5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "cortisone b-reductase activity" EXACT [] +synonym: "cortisone beta-reductase activity" EXACT [] +synonym: "cortisone delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "cortisone delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "delta(4)-hydrogenase activity" EXACT [EC:1.3.1.23] +synonym: "delta-4-3-oxosteroid 5-beta-reductase activity" EXACT [] +synonym: "delta4-3-ketosteroid 5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "delta4-5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "delta4-hydrogenase activity" EXACT [EC:1.3.1.23] +synonym: "steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "steroid 5beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "testosterone 5-beta-reductase activity" EXACT [EC:1.3.1.23] +synonym: "testosterone 5beta-reductase activity" EXACT [EC:1.3.1.23] +xref: EC:1.3.1.3 +xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN +xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047788 +name: 2-coumarate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH." [EC:1.3.1.11, MetaCyc:COUMARATE-REDUCTASE-RXN] +synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.11] +synonym: "coumarate reductase activity" EXACT [] +synonym: "melilotate dehydrogenase activity" EXACT [EC:1.3.1.11] +xref: EC:1.3.1.11 +xref: MetaCyc:COUMARATE-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047789 +name: creatininase activity +namespace: molecular_function +def: "Catalysis of the reaction: creatinine + H2O = creatine." [EC:3.5.2.10, MetaCyc:CREATININASE-RXN] +subset: gosubset_prok +synonym: "creatinine amidohydrolase activity" EXACT [EC:3.5.2.10] +synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10] +xref: EC:3.5.2.10 +xref: MetaCyc:CREATININASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047790 +name: creatinine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN] +subset: gosubset_prok +synonym: "creatinine desiminase activity" EXACT [EC:3.5.4.21] +synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21] +synonym: "creatinine iminohydrolase activity" EXACT [EC:3.5.4.21] +xref: EC:3.5.4.21 +xref: MetaCyc:CREATININE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047791 +name: cucurbitacin delta23-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN] +synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] +synonym: "cucurbitacin D23-reductase activity" EXACT [] +synonym: "cucurbitacin delta(23) reductase activity" EXACT [] +synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" EXACT [EC:1.3.1.5] +xref: EC:1.3.1.5 +xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047792 +name: cyanohydrin beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDPglucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "cyanohydrin b-glucosyltransferase activity" EXACT [] +synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] +synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] +synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85] +synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" EXACT [EC:2.4.1.85] +synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85] +synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.85] +synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85] +synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.85] +xref: EC:2.4.1.85 +xref: MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047793 +name: cycloeucalenol cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN] +synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" EXACT [EC:5.5.1.9] +synonym: "cycloeucalenol--obtusifoliol isomerase activity" EXACT [EC:5.5.1.9] +synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT [] +xref: EC:5.5.1.9 +xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047794 +name: cyclohexadienyl dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "arogenate dehydrogenase activity" EXACT [EC:1.3.1.43] +synonym: "arogenic dehydrogenase activity" EXACT [EC:1.3.1.43] +synonym: "L-arogenate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.43] +synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.43] +synonym: "L-arogenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.43] +synonym: "pretyrosine dehydrogenase activity" EXACT [EC:1.3.1.43] +xref: EC:1.3.1.43 +xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047795 +name: cyclohexane-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-1\,2-DIOL-DEHYDROGENASE-RXN] +synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.174] +xref: EC:1.1.1.174 +xref: MetaCyc:CYCLOHEXANE-1\,2-DIOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047796 +name: cyclohexane-1,3-dione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate." [EC:3.7.1.10, MetaCyc:CYCLOHEXANE-1\,3-DIONE-HYDROLASE-RXN] +synonym: "1,3-cyclohexanedione hydrolase activity" EXACT [EC:3.7.1.10] +synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" EXACT [EC:3.7.1.10] +xref: EC:3.7.1.10 +xref: MetaCyc:CYCLOHEXANE-1\,3-DIONE-HYDROLASE-RXN +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0047797 +name: cyclohexanone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexanone + acceptor = cyclohex-2-enone + reduced acceptor." [EC:1.3.99.14, MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN] +synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.3.99.14] +synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" EXACT [EC:1.3.99.14] +xref: EC:1.3.99.14 +xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047798 +name: cyclomaltodextrinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN] +subset: gosubset_prok +synonym: "cyclodextrinase activity" EXACT [EC:3.2.1.54] +synonym: "cycloheptaglucanase activity" EXACT [EC:3.2.1.54] +synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54] +synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54] +xref: EC:3.2.1.54 +xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047799 +name: cyclopentanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopentanone + NADPH + O2 = 5-valerolactone + NADP+ + H2O." [EC:1.14.13.16, MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN] +synonym: "cyclopentanone 1,2-monooxygenase activity" EXACT [EC:1.14.13.16] +synonym: "cyclopentanone oxygenase activity" EXACT [EC:1.14.13.16] +synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" EXACT [EC:1.14.13.16] +xref: EC:1.14.13.16 +xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047800 +name: cysteamine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cysteamine + O2 = hypotaurine." [EC:1.13.11.19, MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN] +synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] +synonym: "cysteamine oxygenase activity" EXACT [EC:1.13.11.19] +synonym: "cysteamine:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19] +synonym: "persulfurase activity" RELATED [EC:1.13.11.19] +xref: EC:1.13.11.19 +xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047801 +name: cysteine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [EC:2.6.1.3, MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN] +synonym: "CGT" RELATED [EC:2.6.1.3] +synonym: "cysteine aminotransferase activity" EXACT [] +synonym: "L-cysteine aminotransferase activity" EXACT [EC:2.6.1.3] +synonym: "L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.3] +xref: EC:2.6.1.3 +xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047802 +name: cysteine-conjugate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)-mercaptopyruvate + L-glutamate." [EC:2.6.1.75, MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN] +synonym: "cysteine conjugate aminotransferase activity" EXACT [EC:2.6.1.75] +synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" EXACT [EC:2.6.1.75] +synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.75] +xref: EC:2.6.1.75 +xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047803 +name: cysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + SO3(2-) (sulfite) = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN] +synonym: "cysteine (sulfite) lyase activity" EXACT [EC:4.4.1.10] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" EXACT [EC:4.4.1.10] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" EXACT [EC:4.4.1.10] +xref: EC:4.4.1.10 +xref: MetaCyc:CYSTEINE-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047804 +name: cysteine-S-conjugate beta-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN] +subset: gosubset_prok +synonym: "cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] +synonym: "cysteine-S-conjugate b-lyase activity" EXACT [] +synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13] +synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4.4.1.13] +synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13] +xref: EC:4.4.1.13 +xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047805 +name: cytidylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate." [EC:4.6.1.6, MetaCyc:CYTIDYLATE-CYCLASE-RXN] +synonym: "3',5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] +synonym: "3'5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6] +synonym: "CTP diphosphate-lyase (cyclizing)" EXACT [EC:4.6.1.6] +synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" EXACT [EC:4.6.1.6] +synonym: "cytidyl cyclase activity" EXACT [EC:4.6.1.6] +synonym: "cytidylyl cyclase activity" EXACT [EC:4.6.1.6] +xref: EC:4.6.1.6 +xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0047806 +name: cytochrome-c3 hydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN] +subset: gosubset_prok +synonym: "cytochrome c3 reductase activity" EXACT [EC:1.12.2.1] +synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1] +synonym: "H(2):ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] +synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1] +synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1] +xref: EC:1.12.2.1 +xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0481 +is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor + +[Term] +id: GO:0047807 +name: cytokinin 7-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-7-beta-D-glucoside." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT [] +synonym: "cytokinin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] +synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] +synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] +synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] +synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118] +xref: EC:2.4.1.118 +xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047808 +name: D(-)-tartrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S,S)-tartrate = oxaloacetate + H2O." [EC:4.2.1.81, MetaCyc:D(-)-TARTRATE-DEHYDRATASE-RXN] +synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.81] +synonym: "(S,S)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.81] +synonym: "D-tartrate dehydratase activity" EXACT [EC:4.2.1.81] +xref: EC:4.2.1.81 +xref: MetaCyc:D(-)-TARTRATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047809 +name: D-2-hydroxy-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + acceptor = pyruvate + reduced acceptor." [EC:1.1.99.6, MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN] +synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.6] +synonym: "2-hydroxy acid dehydrogenase activity" EXACT [EC:1.1.99.6] +xref: EC:1.1.99.6 +xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047810 +name: D-alanine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "D-alanine aminotransferase activity" EXACT [] +synonym: "D-alanine-D-glutamate transaminase activity" EXACT [EC:2.6.1.21] +synonym: "D-alanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.21] +synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21] +synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21] +synonym: "D-amino-acid transaminase activity" EXACT [EC:2.6.1.21] +synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21] +synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21] +synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21] +xref: EC:2.6.1.21 +xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047811 +name: D-alanine gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + D-alanine = NH3 + g-L-glutamyl-D-alanine." [EC:2.3.2.14, MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] +synonym: "D-alanine g-glutamyltransferase activity" EXACT [] +synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" EXACT [EC:2.3.2.14] +xref: EC:2.3.2.14 +xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0047812 +name: D-amino-acid N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" EXACT [EC:2.3.1.36] +synonym: "D-amino acid acetyltransferase activity" EXACT [EC:2.3.1.36] +synonym: "D-amino acid-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.36] +xref: EC:2.3.1.36 +xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047813 +name: D-arabinitol 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN] +subset: gosubset_prok +xref: EC:1.1.1.11 +xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047814 +name: D-arabinokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-arabinose = ADP + D-arabinose 5-phosphate." [EC:2.7.1.54, MetaCyc:D-ARABINOKINASE-RXN] +synonym: "ATP:D-arabinose 5-phosphotransferase activity" EXACT [EC:2.7.1.54] +synonym: "D-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.54] +xref: EC:2.7.1.54 +xref: MetaCyc:D-ARABINOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047815 +name: D-arabinonolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate." [EC:3.1.1.30, MetaCyc:D-ARABINONOLACTONASE-RXN] +synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.30] +xref: EC:3.1.1.30 +xref: MetaCyc:D-ARABINONOLACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047816 +name: D-arabinose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN] +synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116] +synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.116] +synonym: "NAD-pentose-dehydrogenase activity" EXACT [EC:1.1.1.116] +xref: EC:1.1.1.116 +xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047817 +name: D-arginase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea." [EC:3.5.3.10, MetaCyc:D-ARGINASE-RXN] +synonym: "D-arginine amidinohydrolase activity" EXACT [EC:3.5.3.10] +xref: EC:3.5.3.10 +xref: MetaCyc:D-ARGINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047818 +name: D-fuconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O." [EC:4.2.1.67, MetaCyc:D-FUCONATE-HYDRATASE-RXN] +synonym: "D-fuconate hydratase activity" EXACT [] +synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" EXACT [EC:4.2.1.67] +synonym: "D-fuconate hydro-lyase activity" EXACT [EC:4.2.1.67] +xref: EC:4.2.1.67 +xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047819 +name: D-glutamate(D-aspartate) oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATE(D-ASPARTATE)-OXIDASE-RXN] +synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.15] +synonym: "D-glutamic-aspartic oxidase activity" EXACT [EC:1.4.3.15] +synonym: "D-monoaminodicarboxylic acid oxidase activity" EXACT [EC:1.4.3.15] +xref: EC:1.4.3.15 +xref: MetaCyc:D-GLUTAMATE(D-ASPARTATE)-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0047820 +name: D-glutamate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, MetaCyc:D-GLUTAMATE-CYCLASE-RXN] +synonym: "D-glutamate hydro-lyase (cyclizing)" EXACT [EC:4.2.1.48] +synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" EXACT [EC:4.2.1.48] +xref: EC:4.2.1.48 +xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047821 +name: D-glutamate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2; D-aspartate + H2O = oxaloacetate + NH3 + H2O2." [BRENDA:1.4.3.15, EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN] +synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.7] +synonym: "D-glutamic acid oxidase activity" EXACT [EC:1.4.3.7] +synonym: "D-glutamic oxidase activity" EXACT [EC:1.4.3.7] +xref: EC:1.4.3.7 +xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0047822 +name: hypotaurine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hypotaurine + H2O + NAD+ = taurine + NADH." [EC:1.8.1.3, MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN] +synonym: "hypotaurine:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.3] +xref: EC:1.8.1.3 +xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047823 +name: D-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN] +synonym: "D-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] +synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1] +synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1] +xref: EC:2.3.2.1 +xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0047824 +name: D-iditol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN] +xref: EC:1.1.1.15 +xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0047825 +name: D-lactate-2-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-O-sulfolactate + H2O = (S)-lactate + SO4(2-) (sulfate)." [EC:3.1.6.17, MetaCyc:D-LACTATE-2-SULFATASE-RXN] +synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" EXACT [EC:3.1.6.17] +synonym: "D-lactate-2-sulphatase activity" EXACT [] +xref: EC:3.1.6.17 +xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047826 +name: D-lysine 5,6-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, MetaCyc:D-LYSINE-5\,6-AMINOMUTASE-RXN] +synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.4] +synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.4] +synonym: "D-alpha-lysine mutase activity" EXACT [EC:5.4.3.4] +xref: EC:5.4.3.4 +xref: MetaCyc:D-LYSINE-5\,6-AMINOMUTASE-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0047827 +name: D-lysopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH." [EC:1.5.1.16, MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] +synonym: "D(+)-lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] +synonym: "D-lysopine synthase activity" EXACT [EC:1.5.1.16] +synonym: "lysopine dehydrogenase activity" EXACT [EC:1.5.1.16] +synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16] +xref: EC:1.5.1.16 +xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047828 +name: D-lyxose ketol-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN] +synonym: "D-lyxose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.15] +synonym: "D-lyxose isomerase activity" EXACT [EC:5.3.1.15] +xref: EC:5.3.1.15 +xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0047829 +name: D-nopaline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] +synonym: "D-nopaline synthase activity" EXACT [EC:1.5.1.19] +synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19] +synonym: "nopaline dehydrogenase activity" EXACT [EC:1.5.1.19] +synonym: "nopaline synthase activity" EXACT [EC:1.5.1.19] +synonym: "NOS activity" EXACT [EC:1.5.1.19] +xref: EC:1.5.1.19 +xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047830 +name: D-octopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] +synonym: "D-octopine synthase activity" EXACT [EC:1.5.1.11] +synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11] +synonym: "octopine dehydrogenase activity" EXACT [EC:1.5.1.11] +synonym: "octopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.11] +synonym: "ODH activity" EXACT [EC:1.5.1.11] +xref: EC:1.5.1.11 +xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047831 +name: D-ornithine 4,5-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, MetaCyc:ORNMUTST-RXN] +synonym: "D-alpha-ornithine 5,4-aminomutase activity" EXACT [EC:5.4.3.5] +synonym: "D-ornithine aminomutase activity" EXACT [EC:5.4.3.5] +xref: EC:5.4.3.5 +xref: MetaCyc:ORNMUTST-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0047832 +name: D-pinitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH." [EC:1.1.1.142, MetaCyc:D-PINITOL-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] +synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142] +xref: EC:1.1.1.142 +xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047833 +name: D-sorbitol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN] +synonym: "D-sorbitol dehydrogenase activity" EXACT [] +synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.21] +synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.21] +xref: EC:1.1.99.21 +xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047834 +name: D-threo-aldose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "(2S,3R)-aldose dehydrogenase activity" EXACT [EC:1.1.1.122] +synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.122] +synonym: "dehydrogenase, L-fucose" EXACT [EC:1.1.1.122] +synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122] +synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122] +xref: EC:1.1.1.122 +xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047835 +name: D-tryptophan N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + D-tryptophan = CoA + N-acetyl-D-tryptophan." [EC:2.3.1.34, MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.34] +synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" EXACT [EC:2.3.1.34] +synonym: "D-tryptophan acetyltransferase activity" EXACT [EC:2.3.1.34] +xref: EC:2.3.1.34 +xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047836 +name: D-tryptophan N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan." [EC:2.3.1.112, MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN] +synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" EXACT [EC:2.3.1.112] +xref: EC:2.3.1.112 +xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN +is_a: GO:0050735 ! N-malonyltransferase activity + +[Term] +id: GO:0047837 +name: D-xylose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH." [EC:1.1.1.179, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-(NADP+)-RXN] +subset: gosubset_prok +synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.179] +synonym: "D-xylose-NADP dehydrogenase activity" EXACT [EC:1.1.1.179] +synonym: "D-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.179] +synonym: "D-xylose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.179] +xref: EC:1.1.1.179 +xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047838 +name: D-xylose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN] +synonym: "(NAD)-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] +synonym: "D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] +synonym: "D-xylose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.175] +synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175] +synonym: "NAD-D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] +synonym: "NAD-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175] +xref: EC:1.1.1.175 +xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047839 +name: dATP(dGTP)-DNA purinetransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATP(DGTP)--DNA-PURINE-TRANSFERASE-RXN] +synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT [] +synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" EXACT [EC:2.6.99.1] +xref: EC:2.6.99.1 +xref: MetaCyc:DATP(DGTP)--DNA-PURINE-TRANSFERASE-RXN +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0047840 +name: dCTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [EC:3.6.1.12, MetaCyc:DCTP-PYROPHOSPHATASE-RXN] +synonym: "dCTP nucleotidohydrolase activity" EXACT [EC:3.6.1.12] +synonym: "dCTP pyrophosphatase activity" EXACT [] +synonym: "dCTPase activity" EXACT [EC:3.6.1.12] +synonym: "deoxy-CTPase activity" EXACT [EC:3.6.1.12] +synonym: "deoxycytidine triphosphatase activity" EXACT [EC:3.6.1.12] +synonym: "deoxycytidine-triphosphatase activity" EXACT [EC:3.6.1.12] +xref: EC:3.6.1.12 +xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0047841 +name: dehydrogluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate." [EC:2.7.1.13, MetaCyc:DEHYDOGLUCONOKINASE-RXN] +synonym: "2-ketogluconate kinase activity" EXACT [EC:2.7.1.13] +synonym: "2-ketogluconokinase activity" EXACT [EC:2.7.1.13] +synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.13] +synonym: "dehydogluconokinase activity" EXACT [] +synonym: "ketogluconokinase (phosphorylating)" EXACT [EC:2.7.1.13] +synonym: "ketogluconokinase activity" EXACT [EC:2.7.1.13] +xref: EC:2.7.1.13 +xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047842 +name: dehydro-L-gulonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydro-L-gulonate = L-xylulose + CO2." [EC:4.1.1.34, MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN] +synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" EXACT [EC:4.1.1.34] +synonym: "3-dehydro-L-gulonate carboxy-lyase activity" EXACT [EC:4.1.1.34] +synonym: "3-keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] +synonym: "keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34] +xref: EC:4.1.1.34 +xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047843 +name: dehydrogluconate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-D-gluconate + acceptor = 2,5-didehydro-D-gluconate + reduced acceptor." [EC:1.1.99.4, MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN] +synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.4] +synonym: "2-keto-D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.4] +synonym: "2-oxogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] +synonym: "alpha-ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] +synonym: "ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4] +xref: EC:1.1.99.4 +xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047844 +name: deoxycytidine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN] +subset: gosubset_prok +synonym: "deoxycytidine aminohydrolase activity" EXACT [EC:3.5.4.14] +xref: EC:3.5.4.14 +xref: MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047845 +name: deoxylimonate A-ring-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxylimonate + H2O = deoxylimononic acid D-ring-lactone." [EC:3.1.1.46, MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN] +synonym: "deoxylimonate A-ring-lactonohydrolase activity" EXACT [EC:3.1.1.46] +xref: EC:3.1.1.46 +xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047846 +name: deoxynucleotide 3'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3'-PHOSPHATASE-RXN] +synonym: "3'-deoxynucleotidase activity" EXACT [EC:3.1.3.34] +synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34] +synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34] +xref: EC:3.1.3.34 +xref: MetaCyc:DEOXYNUCLEOTIDE-3'-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047847 +name: deoxyuridine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN] +synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] +synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] +synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.23] +xref: EC:2.4.2.23 +xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047848 +name: dephospho-[reductase kinase] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-[REDUCTASE-KINASE\]-KINASE-RXN] +synonym: "AMP-activated kinase activity" EXACT [EC:2.7.11.3] +synonym: "AMP-activated protein kinase kinase activity" EXACT [EC:2.7.11.3] +synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" EXACT [EC:2.7.11.3] +synonym: "dephospho-reductase kinase kinase activity" EXACT [EC:2.7.11.3] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" EXACT [EC:2.7.11.3] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" EXACT [EC:2.7.11.3] +synonym: "reductase kinase activity" BROAD [EC:2.7.11.3] +synonym: "reductase kinase kinase activity" EXACT [EC:2.7.11.3] +synonym: "STK30" RELATED [EC:2.7.11.3] +xref: EC:2.7.11.3 +xref: MetaCyc:DEPHOSPHO-[REDUCTASE-KINASE\]-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047849 +name: dextransucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN] +subset: gosubset_prok +synonym: "CEP" RELATED [EC:2.4.1.5] +synonym: "SGE" RELATED [EC:2.4.1.5] +synonym: "sucrose 6-glucosyltransferase activity" EXACT [EC:2.4.1.5] +synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.5] +synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.5] +xref: EC:2.4.1.5 +xref: MetaCyc:DEXTRANSUCRASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0047850 +name: diaminopimelate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH." [EC:1.4.1.16, MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.16] +synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] +synonym: "meso-diaminopimelate D-dehydrogenase activity" EXACT [EC:1.4.1.16] +synonym: "meso-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16] +xref: EC:1.4.1.16 +xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047851 +name: dicarboxylate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid = AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN] +synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23] +synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23] +xref: EC:6.2.1.23 +xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047852 +name: diferric-transferrin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [EC:1.16.1.2, MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN] +synonym: "diferric transferrin reductase activity" EXACT [EC:1.16.1.2] +synonym: "NADH diferric transferrin reductase activity" EXACT [EC:1.16.1.2] +synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2] +synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2] +xref: EC:1.16.1.2 +xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0047853 +name: difructose-anhydride synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN] +synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" EXACT [EC:3.2.1.134] +synonym: "inulobiose hydrolase activity" EXACT [EC:3.2.1.134] +xref: EC:3.2.1.134 +xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047854 +name: diguanidinobutanase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea." [EC:3.5.3.20, MetaCyc:DIGUANIDINOBUTANASE-RXN] +synonym: "1,4-diguanidinobutane amidinohydrolase activity" EXACT [EC:3.5.3.20] +xref: EC:3.5.3.20 +xref: MetaCyc:DIGUANIDINOBUTANASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047855 +name: dihydrobunolol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH." [EC:1.1.1.160, MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN] +synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.160] +synonym: "bunolol reductase activity" EXACT [EC:1.1.1.160] +xref: EC:1.1.1.160 +xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047856 +name: dihydrocoumarin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrocoumarin + H2O = melilotate." [EC:3.1.1.35, MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN] +subset: gosubset_prok +synonym: "dihydrocoumarin lactonohydrolase activity" EXACT [EC:3.1.1.35] +synonym: "dihydrocoumarin lipase activity" EXACT [] +xref: EC:3.1.1.35 +xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047857 +name: dihydrouracil oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + O2 = uracil + H2O2." [EC:1.3.3.7, MetaCyc:DIHYDROURACIL-OXIDASE-RXN] +synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" EXACT [EC:1.3.3.7] +xref: EC:1.3.3.7 +xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0047858 +name: dihydroxyfumarate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroxyfumarate = tartronate semialdehyde + CO2." [EC:4.1.1.54, MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN] +synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.54] +synonym: "dihydroxyfumarate carboxy-lyase activity" EXACT [EC:4.1.1.54] +xref: EC:4.1.1.54 +xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047859 +name: dihydroxyphenylalanine ammonia-lyase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN] +comment: This term was made obsolete because the corresponding EC reaction has been deleted from the EC. +synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" EXACT [EC:4.3.1.11] +synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.11] +synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" EXACT [EC:4.3.1.11] +xref: EC:4.3.1.11 +xref: MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN +is_obsolete: true + +[Term] +id: GO:0047860 +name: diiodophenylpyruvate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.96, MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN] +synonym: "2-oxo acid reductase activity" EXACT [EC:1.1.1.96] +synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.96] +synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96] +synonym: "KAR" RELATED [EC:1.1.1.96] +xref: EC:1.1.1.96 +xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047861 +name: diiodotyrosine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.24, MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN] +synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.24] +synonym: "diiodotyrosine aminotransferase activity" EXACT [] +synonym: "halogenated tyrosine aminotransferase activity" EXACT [EC:2.6.1.24] +synonym: "halogenated tyrosine transaminase activity" EXACT [EC:2.6.1.24] +xref: EC:2.6.1.24 +xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047862 +name: diisopropyl-fluorophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride." [EC:3.1.8.2, MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN] +synonym: "DFPase activity" EXACT [EC:3.1.8.2] +synonym: "dialkylfluorophosphatase activity" EXACT [EC:3.1.8.2] +synonym: "diisopropyl phosphorofluoridate hydrolase activity" EXACT [EC:3.1.8.2] +synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" EXACT [EC:3.1.8.2] +synonym: "diisopropylfluorophosphonate dehalogenase activity" EXACT [EC:3.1.8.2] +synonym: "diisopropylphosphofluoridase activity" EXACT [EC:3.1.8.2] +synonym: "isopropylphosphorofluoridase activity" EXACT [EC:3.1.8.2] +synonym: "OPA anhydrase activity" EXACT [EC:3.1.8.2] +synonym: "OPAA activity" EXACT [EC:3.1.8.2] +synonym: "organophosphate acid anhydrase activity" EXACT [EC:3.1.8.2] +synonym: "organophosphorus acid anhydrolase activity" EXACT [EC:3.1.8.2] +synonym: "somanase activity" EXACT [EC:3.1.8.2] +synonym: "tabunase activity" EXACT [EC:3.1.8.2] +xref: EC:3.1.8.2 +xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN +is_a: GO:0016795 ! phosphoric triester hydrolase activity + +[Term] +id: GO:0047863 +name: dimethylallylcistransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN] +synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" EXACT [EC:2.5.1.28] +synonym: "neryl-diphosphate synthase activity" EXACT [EC:2.5.1.28] +xref: EC:2.5.1.28 +xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0047864 +name: dimethylaniline-N-oxide aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN] +subset: gosubset_prok +synonym: "microsomal N-oxide dealkylase activity" EXACT [EC:4.1.2.24] +synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24] +synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" EXACT [EC:4.1.2.24] +synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.24] +xref: EC:4.1.2.24 +xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047865 +name: dimethylglycine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor." [EC:1.5.99.2, MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "N,N-dimethylglycine oxidase activity" EXACT [EC:1.5.99.2] +synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.2] +synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.2] +xref: EC:1.5.99.2 +xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0047866 +name: dimethylglycine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2." [EC:1.5.3.10, MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN] +synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.10] +xref: EC:1.5.3.10 +xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0047867 +name: dimethylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH." [EC:1.1.1.84, MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN] +synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.84] +synonym: "beta,beta-dimethylmalate dehydrogenase activity" EXACT [EC:1.1.1.84] +xref: EC:1.1.1.84 +xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047868 +name: dimethylmaleate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O." [EC:4.2.1.85, MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN] +synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" EXACT [EC:4.2.1.85] +synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" EXACT [EC:4.2.1.85] +xref: EC:4.2.1.85 +xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047869 +name: dimethylpropiothetin dethiomethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate." [EC:4.4.1.3, MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN] +synonym: "desulfhydrase activity" EXACT [EC:4.4.1.3] +synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" EXACT [EC:4.4.1.3] +synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" EXACT [EC:4.4.1.3] +xref: EC:4.4.1.3 +xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047870 +name: discadenine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N6-(D2-isopentenyl)-adenine = 5'-methylthioadenosine + discadenine." [EC:2.5.1.24, MetaCyc:DISCADENINE-SYNTHASE-RXN] +synonym: "discadenine synthetase activity" EXACT [EC:2.5.1.24] +synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" EXACT [EC:2.5.1.24] +synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24] +xref: EC:2.5.1.24 +xref: MetaCyc:DISCADENINE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047871 +name: disulfoglucosamine-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,6-O-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + SO4(2-) (sulfate)." [EC:3.1.6.11, MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN] +synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" EXACT [EC:3.1.6.11] +synonym: "disulphoglucosamine-6-sulphatase activity" EXACT [] +synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" EXACT [EC:3.1.6.11] +synonym: "N-sulfoglucosamine-6-sulfatase activity" EXACT [EC:3.1.6.11] +xref: EC:3.1.6.11 +xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047872 +name: dolichol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123] +synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123] +xref: EC:2.3.1.123 +xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047873 +name: dolichyl-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN] +synonym: "Dol-P phosphatase activity" EXACT [EC:3.1.3.51] +synonym: "Dol-P-P phosphohydrolase activity" EXACT [] +synonym: "dolichol monophosphatase activity" EXACT [EC:3.1.3.51] +synonym: "dolichol phosphatase activity" EXACT [EC:3.1.3.51] +synonym: "dolichol phosphate phosphatase activity" EXACT [EC:3.1.3.51] +synonym: "dolichyl monophosphate phosphatase activity" EXACT [EC:3.1.3.51] +synonym: "dolichyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] +synonym: "dolichyl pyrophosphate phosphatase activity" EXACT [] +synonym: "dolichyl-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.51] +synonym: "polyisoprenyl phosphate phosphatase activity" EXACT [EC:3.1.3.51] +synonym: "polyprenylphosphate phosphatase activity" EXACT [EC:3.1.3.51] +xref: EC:3.1.3.51 +xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047874 +name: dolichyldiphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN] +synonym: "dolichol diphosphatase activity" EXACT [EC:3.6.1.43] +synonym: "dolichyl diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] +synonym: "dolichyl pyrophosphatase activity" EXACT [EC:3.6.1.43] +synonym: "dolichyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43] +xref: EC:3.6.1.43 +xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047875 +name: ecdysone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ecdysone + O2 = 3-dehydroecdysone + H2O2." [EC:1.1.3.16, MetaCyc:ECDYSONE-OXIDASE-RXN] +synonym: "beta-ecdysone oxidase activity" EXACT [EC:1.1.3.16] +synonym: "ecdysone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.16] +xref: EC:1.1.3.16 +xref: MetaCyc:ECDYSONE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047876 +name: endoglycosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN] +subset: gosubset_prok +synonym: "EGCase activity" EXACT [EC:3.2.1.123] +synonym: "endo-glucosylceramidase activity" EXACT [EC:3.2.1.123] +synonym: "endoglycoceramidase activity" EXACT [EC:3.2.1.123] +synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.123] +synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123] +xref: EC:3.2.1.123 +xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047877 +name: ephedrine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH." [EC:1.5.1.18, MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN] +synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" EXACT [EC:1.5.1.18] +xref: EC:1.5.1.18 +xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047878 +name: erythritol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + erythritol = ADP + D-erythritol 4-phosphate." [EC:2.7.1.27, MetaCyc:ERYTHRITOL-KINASE-RXN] +subset: gosubset_prok +synonym: "ATP:erythritol 4-phosphotransferase activity" EXACT [EC:2.7.1.27] +synonym: "erythritol kinase (phosphorylating)" EXACT [EC:2.7.1.27] +xref: EC:2.7.1.27 +xref: MetaCyc:ERYTHRITOL-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047879 +name: erythronolide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN] +subset: gosubset_prok +synonym: "erythronolide condensing enzyme activity" EXACT [EC:2.3.1.94] +synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.94] +xref: EC:2.3.1.94 +xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047880 +name: erythrulose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: erythritol + NADP+ = D-erythrulose + NADPH." [EC:1.1.1.162, MetaCyc:ERYTHRULOSE-REDUCTASE-RXN] +synonym: "D-erythrulose reductase activity" EXACT [EC:1.1.1.162] +synonym: "erythritol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.162] +xref: EC:1.1.1.162 +xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047881 +name: estradiol 17-alpha-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN] +synonym: "17alpha-estradiol dehydrogenase activity" EXACT [EC:1.1.1.148] +synonym: "17alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.148] +synonym: "17alpha-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.1.148] +synonym: "17alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.148] +synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.148] +synonym: "estradiol 17a-dehydrogenase activity" EXACT [] +synonym: "estradiol 17alpha-dehydrogenase activity" EXACT [EC:1.1.1.148] +synonym: "estradiol 17alpha-oxidoreductase activity" EXACT [EC:1.1.1.148] +xref: EC:1.1.1.148 +xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047882 +name: estradiol 6-beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17-beta + donor-H2 + O2 = 6-beta-hydroxyestradiol-17-beta + acceptor + H2O." [EC:1.14.99.11, MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN] +synonym: "estradiol 6-beta-hydroxylase activity" EXACT [EC:1.14.99.11] +synonym: "estradiol 6b-hydroxylase activity" EXACT [] +synonym: "estradiol 6b-monooxygenase activity" EXACT [] +synonym: "estradiol 6beta-hydroxylase activity" EXACT [EC:1.14.99.11] +synonym: "estradiol 6beta-monooxygenase activity" EXACT [EC:1.14.99.11] +synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" EXACT [EC:1.14.99.11] +xref: EC:1.14.99.11 +xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047883 +name: ethanolamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN] +synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.8] +xref: EC:1.4.3.8 +xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0047884 +name: FAD diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN] +synonym: "FAD nucleotidohydrolase activity" EXACT [EC:3.6.1.18] +synonym: "FAD pyrophosphatase activity" EXACT [] +synonym: "flavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] +synonym: "flavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] +synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] +synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18] +xref: EC:3.6.1.18 +xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0047885 +name: farnesol 2-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, MetaCyc:FARNESOL-2-ISOMERASE-RXN] +subset: gosubset_prok +synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" EXACT [EC:5.2.1.9] +synonym: "farnesol isomerase activity" EXACT [EC:5.2.1.9] +xref: EC:5.2.1.9 +xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047886 +name: farnesol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + NADPH." [EC:1.1.1.216, MetaCyc:FARNESOL-DEHYDROGENASE-RXN] +synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.216] +synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.216] +synonym: "NADP-farnesol dehydrogenase activity" EXACT [EC:1.1.1.216] +xref: EC:1.1.1.216 +xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047887 +name: farnesyl diphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + farnesyl diphosphate = ADP + farnesyl triphosphate." [EC:2.7.4.18, MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN] +synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.18] +synonym: "farnesyl pyrophosphate kinase activity" EXACT [EC:2.7.4.18] +synonym: "farnesyl-diphosphate kinase activity" EXACT [] +xref: EC:2.7.4.18 +xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047888 +name: fatty-acid peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitate + 2 H2O2 = pentadecanal + CO2 + 3 H2O." [EC:1.11.1.3, MetaCyc:FATTY-ACID-PEROXIDASE-RXN] +synonym: "fatty acid peroxidase activity" EXACT [] +synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.3] +synonym: "long chain fatty acid peroxidase activity" EXACT [EC:1.11.1.3] +xref: EC:1.11.1.3 +xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0047889 +name: ferredoxin-nitrate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NO2- (nitrite) + H2O + 2 oxidized ferredoxin = NO3- (nitrate) + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN] +synonym: "assimilatory ferredoxin-nitrate reductase activity" EXACT [EC:1.7.7.2] +synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2] +synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2] +synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2] +xref: EC:1.7.7.2 +xref: MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN +is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0047890 +name: flavanone 4-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN] +synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.234] +synonym: "flavonone 4-reductase activity" EXACT [] +xref: EC:1.1.1.234 +xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047891 +name: flavone 7-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.81] +synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" EXACT [EC:2.4.1.81] +xref: EC:2.4.1.81 +xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047892 +name: flavone apiosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN] +synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" EXACT [EC:2.4.2.25] +synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] +synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25] +xref: EC:2.4.2.25 +xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047893 +name: flavonol 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN] +synonym: "GTI" RELATED [EC:2.4.1.91] +synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] +synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] +synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] +synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] +synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91] +synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91] +xref: EC:2.4.1.91 +xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047894 +name: flavonol 3-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate." [EC:2.8.2.25, MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT [EC:2.8.2.25] +synonym: "flavonol 3-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.25 +xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047895 +name: formaldehyde dismutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.99.4, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN] +synonym: "aldehyde dismutase activity" EXACT [EC:1.2.99.4] +synonym: "cannizzanase activity" EXACT [EC:1.2.99.4] +synonym: "formaldehyde:formaldehyde oxidoreductase activity" EXACT [EC:1.2.99.4] +xref: EC:1.2.99.4 +xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0047896 +name: formaldehyde transketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN] +synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" EXACT [EC:2.2.1.3] +synonym: "DHAS activity" EXACT [EC:2.2.1.3] +synonym: "dihydroxyacetone synthase activity" EXACT [EC:2.2.1.3] +synonym: "glycerone synthase activity" EXACT [EC:2.2.1.3] +xref: EC:2.2.1.3 +xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0047897 +name: formate-dihydrofolate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate." [EC:6.3.4.17, MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN] +synonym: "dihydrofolate formyltransferase activity" EXACT [EC:6.3.4.17] +synonym: "formate:dihydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.17] +synonym: "formyl dihydrofolate synthase activity" EXACT [EC:6.3.4.17] +xref: EC:6.3.4.17 +xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0047898 +name: formate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-(CYTOCHROME)-RXN] +synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1] +synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1] +xref: EC:1.2.2.1 +xref: MetaCyc:FORMATE-DEHYDROGENASE-(CYTOCHROME)-RXN +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0047899 +name: formate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + NADP+ = CO2 + NADPH." [EC:1.2.1.43, MetaCyc:FORMATE-DEHYDROGENASE-(NADP+)-RXN] +subset: gosubset_prok +synonym: "formate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.43] +synonym: "NADP-dependent formate dehydrogenase activity" EXACT [EC:1.2.1.43] +xref: EC:1.2.1.43 +xref: MetaCyc:FORMATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047900 +name: formate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate." [EC:2.7.2.6, MetaCyc:FORMATE-KINASE-RXN] +synonym: "ATP:formate phosphotransferase activity" EXACT [EC:2.7.2.6] +xref: EC:2.7.2.6 +xref: MetaCyc:FORMATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047901 +name: formyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: formyl-CoA + H2O = CoA + formate." [EC:3.1.2.10, MetaCyc:FORMYL-COA-HYDROLASE-RXN] +synonym: "formyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.10] +xref: EC:3.1.2.10 +xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047902 +name: formylaspartate deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN] +synonym: "formylaspartic formylase (formylase I, formylase II)" EXACT [EC:3.5.1.8] +synonym: "N-formyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.8] +xref: EC:3.5.1.8 +xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047903 +name: fructose 5-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-(NADP+)-RXN] +subset: gosubset_prok +synonym: "5-keto-D-fructose reductase (NADP+)" EXACT [EC:1.1.1.124] +synonym: "5-ketofructose reductase (NADP(+)) activity" EXACT [EC:1.1.1.124] +synonym: "5-ketofructose reductase (NADP)" EXACT [EC:1.1.1.124] +synonym: "5-ketofructose reductase (NADP+) activity" EXACT [EC:1.1.1.124] +synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" EXACT [EC:1.1.1.124] +synonym: "D-fructose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.124] +synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.124] +xref: EC:1.1.1.124 +xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047904 +name: fructose 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose + acceptor = 5-dehydro-D-fructose + reduced acceptor." [EC:1.1.99.11, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN] +synonym: "D-fructose dehydrogenase activity" EXACT [EC:1.1.99.11] +synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.11] +synonym: "D-fructose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.11] +synonym: "fructose 5-dehydrogenase (acceptor)" EXACT [EC:1.1.99.11] +xref: EC:1.1.99.11 +xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047905 +name: fructose-6-phosphate phosphoketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN] +subset: gosubset_prok +synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.22] +synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.22] +xref: EC:4.1.2.22 +xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047906 +name: fucosterol-epoxide lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = desmosterol + acetaldehyde." [EC:4.1.2.33, MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN] +synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" EXACT [EC:4.1.2.33] +synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" EXACT [EC:4.1.2.33] +xref: EC:4.1.2.33 +xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047907 +name: furylfuramide isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN] +synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" EXACT [EC:5.2.1.6] +xref: EC:5.2.1.6 +xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047908 +name: fusarinine-C ornithinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN] +synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] +synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48] +synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48] +xref: EC:3.1.1.48 +xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047909 +name: galactolipid O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN] +synonym: "galactolipid:galactolipid acyltransferase activity" EXACT [EC:2.3.1.134] +synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.134] +xref: EC:2.3.1.134 +xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047910 +name: galactose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-(NADP+)-RXN] +synonym: "D-galactose dehydrogenase (NADP+)" EXACT [EC:1.1.1.120] +synonym: "D-galactose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.120] +xref: EC:1.1.1.120 +xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047911 +name: galacturan 1,4-alpha-galacturonidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-alpha-D-galacturonide(n) + H2O = 1,4-alpha-D-galacturonide(n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-1\,4-ALPHA-GALACTURONIDASE-RXN] +synonym: "exo-D-galacturonanase activity" EXACT [EC:3.2.1.67] +synonym: "exo-D-galacturonase activity" EXACT [] +synonym: "exo-polygalacturonase activity" EXACT [] +synonym: "exopoly-D-galacturonase activity" EXACT [] +synonym: "exopolygalacturonase activity" EXACT [EC:3.2.1.67] +synonym: "galacturan 1,4-a-galacturonidase activity" EXACT [] +synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [EC:3.2.1.67] +synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67] +xref: EC:3.2.1.67 +xref: MetaCyc:GALACTURAN-1\,4-ALPHA-GALACTURONIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047912 +name: galacturonokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-galacturonate = ADP + 1-phospho-alpha-D-galacturonate." [EC:2.7.1.44, MetaCyc:GALACTURONOKINASE-RXN] +synonym: "ATP:D-galacturonate 1-phosphotransferase activity" EXACT [EC:2.7.1.44] +synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" EXACT [EC:2.7.1.44] +xref: EC:2.7.1.44 +xref: MetaCyc:GALACTURONOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047913 +name: gallate 1-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + gallate = UDP + 1-galloyl-beta-D-glucose." [EC:2.4.1.136, MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "gallate 1-b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] +synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] +synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136] +synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136] +synonym: "UDPglucose:gallate glucosyltransferase activity" EXACT [EC:2.4.1.136] +synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" EXACT [EC:2.4.1.136] +xref: EC:2.4.1.136 +xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047914 +name: gamma-glutamylhistamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN] +synonym: "g-glutamylhistamine synthase activity" EXACT [] +synonym: "gamma-GHA synthetase activity" EXACT [EC:6.3.2.18] +synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18] +synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18] +xref: EC:6.3.2.18 +xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047915 +name: ganglioside galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] +synonym: "GM1-synthase activity" EXACT [EC:2.4.1.62] +synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "UDP-galactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "UDPgalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62] +synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62] +xref: EC:2.4.1.62 +xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047916 +name: GDP-6-deoxy-D-talose 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN] +synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.135] +synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" EXACT [EC:1.1.1.135] +xref: EC:1.1.1.135 +xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047917 +name: GDP-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-glucose + H2O = D-glucose + GDP." [EC:3.2.1.42, MetaCyc:GDP-GLUCOSIDASE-RXN] +synonym: "GDP-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] +synonym: "GDPglucose glucohydrolase activity" EXACT [EC:3.2.1.42] +synonym: "GDPglucosidase activity" EXACT [EC:3.2.1.42] +synonym: "guanosine diphosphate D-glucose glucohydrolase activity" EXACT [EC:3.2.1.42] +synonym: "guanosine diphosphoglucosidase activity" EXACT [EC:3.2.1.42] +xref: EC:3.2.1.42 +xref: MetaCyc:GDP-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047918 +name: GDP-mannose 3,5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18] +synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" EXACT [EC:5.1.3.18] +synonym: "GDPmannose 3,5-epimerase activity" EXACT [EC:5.1.3.18] +synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" EXACT [EC:5.1.3.18] +xref: EC:5.1.3.18 +xref: MetaCyc:RXN-1882 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047919 +name: GDP-mannose 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH." [EC:1.1.1.132, MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "GDP mannose dehydrogenase activity" EXACT [EC:1.1.1.132] +synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.132] +synonym: "GDPmannose 6-dehydrogenase activity" EXACT [EC:1.1.1.132] +synonym: "guanosine diphospho-D-mannose dehydrogenase activity" EXACT [EC:1.1.1.132] +synonym: "guanosine diphosphomannose dehydrogenase activity" EXACT [EC:1.1.1.132] +xref: EC:1.1.1.132 +xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047920 +name: geissoschizine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + NADPH." [EC:1.3.1.36, MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN] +synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" EXACT [EC:1.3.1.36] +xref: EC:1.3.1.36 +xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047921 +name: aminoglycoside 2'-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 2'-N-acetylaminoglycoside. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [GOC:cb] +synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] +synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] +synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW [] +synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59] +synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW [] +synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59] +xref: EC:2.3.1.59 +xref: MetaCyc:GENTAMICIN-2'-N-ACETYLTRANSFERASE-RXN +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0047922 +name: gentisate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = maleylpyruvate." [EC:1.13.11.4, MetaCyc:GENTISATE-1\,2-DIOXYGENASE-RXN] +subset: gosubset_prok +synonym: "2,5-dihydroxybenzoate dioxygenase activity" EXACT [EC:1.13.11.4] +synonym: "gentisate dioxygenase activity" EXACT [EC:1.13.11.4] +synonym: "gentisate oxygenase activity" EXACT [EC:1.13.11.4] +synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.4] +synonym: "gentisic acid oxidase activity" EXACT [EC:1.13.11.4] +xref: EC:1.13.11.4 +xref: MetaCyc:GENTISATE-1\,2-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047923 +name: gentisate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydroxybenzoate = hydroquinone + CO2." [EC:4.1.1.62, MetaCyc:GENTISATE-DECARBOXYLASE-RXN] +synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" EXACT [EC:4.1.1.62] +synonym: "2,5-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.62] +synonym: "gentisate carboxy-lyase activity" EXACT [EC:4.1.1.62] +xref: EC:4.1.1.62 +xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047924 +name: geraniol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN] +synonym: "geraniol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.183] +xref: EC:1.1.1.183 +xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0734 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047925 +name: geranoyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA." [EC:6.4.1.5, MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN] +synonym: "geranoyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.5] +synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.5] +synonym: "geranyl-CoA carboxylase activity" EXACT [EC:6.4.1.5] +xref: EC:6.4.1.5 +xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0721 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0047926 +name: geranyl-diphosphate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (+)-bornyl diphosphate." [EC:5.5.1.8, MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN] +synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.8] +synonym: "(+)-bornylpyrophosphate cyclase activity" EXACT [EC:5.5.1.8] +synonym: "bornyl diphosphate synthase activity" EXACT [EC:5.5.1.8] +synonym: "bornyl pyrophosphate synthase activity" EXACT [EC:5.5.1.8] +synonym: "bornyl pyrophosphate synthetase activity" EXACT [EC:5.5.1.8] +xref: EC:5.5.1.8 +xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047927 +name: gibberellin-44 dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN] +synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] +synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12] +synonym: "gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] +synonym: "oxygenase, gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12] +xref: EC:1.14.11.12 +xref: MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0047928 +name: gibberellin beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "gibberellin b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] +synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176] +synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.176] +synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" EXACT [EC:2.4.1.176] +xref: EC:2.4.1.176 +xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047929 +name: gluconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.39, MetaCyc:GLUCONATE-DEHYDRATASE-RXN] +subset: gosubset_prok +synonym: "D-gluconate dehydratase activity" EXACT [EC:4.2.1.39] +synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.39] +synonym: "D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.39] +xref: EC:4.2.1.39 +xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047930 +name: glucosaminate ammonia-lyase activity +namespace: molecular_function +alt_id: GO:0050443 +def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN] +comment: Note that this function was EC:4.3.1.21. +synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" EXACT [EC:4.3.1.9] +synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.9] +synonym: "acetylenemonocarboxylic acid hydrase activity" EXACT [EC:4.3.1.9] +synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT [] +synonym: "aminodeoxygluconate dehydratase activity" EXACT [] +synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.3.1.9] +synonym: "D-glucosaminate ammonia-lyase activity" EXACT [EC:4.3.1.9] +synonym: "D-glucosaminate dehydratase activity" EXACT [EC:4.3.1.9] +synonym: "D-glucosaminic acid dehydrase activity" EXACT [EC:4.3.1.9] +synonym: "glucosaminic dehydrase activity" EXACT [EC:4.3.1.9] +xref: EC:4.3.1.9 +xref: MetaCyc:4.3.1.21-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047931 +name: glucosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN] +synonym: "aminodeoxyglucose kinase activity" EXACT [EC:2.7.1.8] +synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.8] +synonym: "ATP:D-glucosamine phosphotransferase activity" EXACT [EC:2.7.1.8] +synonym: "glucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.8] +xref: EC:2.7.1.8 +xref: MetaCyc:GLUCOSAMINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047932 +name: glucosamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine = CoA + N-acetyl-D-glucosamine." [EC:2.3.1.3, MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" EXACT [EC:2.3.1.3] +synonym: "glucosamine acetylase activity" EXACT [EC:2.3.1.3] +synonym: "glucosamine acetyltransferase activity" EXACT [EC:2.3.1.3] +xref: EC:2.3.1.3 +xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047933 +name: glucose-1,6-bisphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate." [EC:2.7.1.106, MetaCyc:GLUCOSE-1\,6-BISPHOSPHATE-SYNTHASE-RXN] +synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] +synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106] +synonym: "glucose 1,6-diphosphate synthase activity" EXACT [EC:2.7.1.106] +synonym: "glucose-1,6-bisphosphate synthetase activity" EXACT [EC:2.7.1.106] +xref: EC:2.7.1.106 +xref: MetaCyc:GLUCOSE-1\,6-BISPHOSPHATE-SYNTHASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047934 +name: glucose 1-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NAD+)-RXN] +synonym: "D-aldohexose dehydrogenase activity" EXACT [EC:1.1.1.118] +synonym: "D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.118] +synonym: "D-glucose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.118] +xref: EC:1.1.1.118 +xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NAD+)-RXN +is_a: GO:0047936 ! glucose 1-dehydrogenase activity + +[Term] +id: GO:0047935 +name: glucose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NADP+)-RXN] +synonym: "D-glucose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.119] +synonym: "NADP-dependent glucose dehydrogenase activity" EXACT [EC:1.1.1.119] +synonym: "NADP-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] +synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119] +xref: EC:1.1.1.119 +xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0047936 ! glucose 1-dehydrogenase activity + +[Term] +id: GO:0047936 +name: glucose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.47] +synonym: "D-glucose dehydrogenase (NAD(P))" EXACT [EC:1.1.1.47] +synonym: "hexose phosphate dehydrogenase activity" EXACT [EC:1.1.1.47] +xref: EC:1.1.1.47 +xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047937 +name: glucose-1-phosphate phosphodismutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN] +subset: gosubset_prok +synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.41] +synonym: "glucose 1-phosphate transphosphorylase activity" EXACT [EC:2.7.1.41] +synonym: "phosphodismutase activity" EXACT [EC:2.7.1.41] +xref: EC:2.7.1.41 +xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047938 +name: glucose-6-phosphate 1-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN] +synonym: "D-glucose-6-phosphate 1-epimerase activity" EXACT [EC:5.1.3.15] +synonym: "glucose-6 phosphate 1-epimerase activity" EXACT [] +xref: EC:5.1.3.15 +xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047939 +name: L-glucuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + NADPH." [EC:1.1.1.19, MetaCyc:GLUCURONATE-REDUCTASE-RXN] +synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19] +synonym: "D-glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] +synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19] +synonym: "glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19] +synonym: "glucuronate reductase activity" EXACT [] +synonym: "NADP-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] +synonym: "TPN-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19] +xref: EC:1.1.1.19 +xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047940 +name: glucuronokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate." [EC:2.7.1.43, MetaCyc:GLUCURONOKINASE-RXN] +synonym: "ATP:D-glucuronate 1-phosphotransferase activity" EXACT [EC:2.7.1.43] +synonym: "glucurono-glucuronokinase activity" EXACT [EC:2.7.1.43] +synonym: "glucuronokinase (phosphorylating)" EXACT [EC:2.7.1.43] +xref: EC:2.7.1.43 +xref: MetaCyc:GLUCURONOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047941 +name: glucuronolactone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH." [EC:1.1.1.20, MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN] +subset: gosubset_prok +xref: EC:1.1.1.20 +xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047942 +name: glutamate-ethylamine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine." [EC:6.3.1.6, MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN] +synonym: "L-glutamate:ethylamine ligase (ADP-forming)" EXACT [EC:6.3.1.6] +synonym: "N(5)-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] +synonym: "N5-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6] +synonym: "N5-ethylglutamine synthetase activity" EXACT [EC:6.3.1.6] +synonym: "theanine synthetase activity" EXACT [EC:6.3.1.6] +xref: EC:6.3.1.6 +xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047943 +name: glutamate-methylamine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + methylamine = ADP + phosphate + N5-methyl-L-glutamine." [EC:6.3.4.12, MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN] +synonym: "gamma-glutamylmethylamide synthetase activity" EXACT [EC:6.3.4.12] +synonym: "L-glutamate:methylamine ligase (ADP-forming)" EXACT [EC:6.3.4.12] +xref: EC:6.3.4.12 +xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0047944 +name: glutamate 1-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate." [EC:2.7.2.13, MetaCyc:GLUTAMATE-1-KINASE-RXN] +synonym: "ATP:L-glutamate 1-phosphotransferase activity" EXACT [EC:2.7.2.13] +xref: EC:2.7.2.13 +xref: MetaCyc:GLUTAMATE-1-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047945 +name: glutamine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "gamma-glutaminyltransferase activity" EXACT [EC:2.6.1.15] +synonym: "glutaminase II activity" EXACT [EC:2.6.1.15] +synonym: "glutamine transaminase activity" EXACT [EC:2.6.1.15] +synonym: "glutamine transaminase L activity" EXACT [EC:2.6.1.15] +synonym: "glutamine--oxo-acid transaminase activity" EXACT [EC:2.6.1.15] +synonym: "glutamine--pyruvate aminotransferase activity" EXACT [] +synonym: "glutamine-alpha-keto acid transamidase activity" EXACT [EC:2.6.1.15] +synonym: "glutamine-alpha-keto acid transaminase activity" EXACT [EC:2.6.1.15] +synonym: "glutamine-keto acid aminotransferase activity" EXACT [EC:2.6.1.15] +synonym: "glutamine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.15] +synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15] +synonym: "L-glutamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.15] +xref: EC:2.6.1.15 +xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047946 +name: glutamine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68] +xref: EC:2.3.1.68 +xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0047947 +name: glutamine N-phenylacetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN] +synonym: "glutamine phenylacetyltransferase activity" EXACT [EC:2.3.1.14] +synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" EXACT [EC:2.3.1.14] +synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" EXACT [EC:2.3.1.14] +xref: EC:2.3.1.14 +xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047948 +name: glutarate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA." [EC:6.2.1.6, MetaCyc:GLUTARATE--COA-LIGASE-RXN] +synonym: "glutarate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.6] +synonym: "glutaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.6] +synonym: "glutaryl-CoA synthetase activity" EXACT [EC:6.2.1.6] +xref: EC:6.2.1.6 +xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047949 +name: glutarate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN] +synonym: "glutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.20] +synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.20] +xref: EC:1.2.1.20 +xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047950 +name: glutathione oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + O2 = oxidized glutathione + H2O2." [EC:1.8.3.3, MetaCyc:GLUTATHIONE-OXIDASE-RXN] +synonym: "glutathione:oxygen oxidoreductase activity" EXACT [EC:1.8.3.3] +xref: EC:1.8.3.3 +xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN +is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0047951 +name: glutathione thiolesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-acylglutathione + H2O = glutathione + a carboxylate." [EC:3.1.2.7, MetaCyc:GLUTATHIONE-THIOESTERASE-RXN] +synonym: "citryl-glutathione thioesterhydrolase activity" EXACT [EC:3.1.2.7] +synonym: "glutathione thioesterase activity" EXACT [] +synonym: "S-acylglutathione hydrolase activity" EXACT [EC:3.1.2.7] +xref: EC:3.1.2.7 +xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0047952 +name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN] +subset: gosubset_prok +synonym: "glycerol 3-phosphate dehydrogenase (NAD(P)) activity" EXACT [EC:1.1.1.94] +synonym: "glycerol 3-phosphate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.94] +synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94] +synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT [] +synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94] +synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.94] +xref: EC:1.1.1.94 +xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047953 +name: glycerol 2-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + NADP+ = glycerone + NADPH." [EC:1.1.1.156, MetaCyc:GLYCEROL-2-DEHYDROGENASE-(NADP+)-RXN] +synonym: "DHA oxidoreductase activity" EXACT [EC:1.1.1.156] +synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.156] +synonym: "dihydroxyacetone reductase (NADPH)" EXACT [EC:1.1.1.156] +synonym: "dihydroxyacetone reductase activity" EXACT [EC:1.1.1.156] +synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" EXACT [EC:1.1.1.156] +xref: EC:1.1.1.156 +xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047954 +name: glycerol-2-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.19, MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN] +synonym: "2-glycerophosphatase activity" EXACT [EC:3.1.3.19] +synonym: "beta-glycerophosphatase activity" EXACT [EC:3.1.3.19] +synonym: "beta-glycerophosphate phosphatase activity" EXACT [EC:3.1.3.19] +synonym: "glycerol-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.19] +xref: EC:3.1.3.19 +xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047955 +name: glycerol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + acceptor = glycerone + reduced acceptor." [EC:1.1.99.22, MetaCyc:GLYCEROL-DEHYDROGENASE-(ACCEPTOR)-RXN] +synonym: "glycerol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.22] +synonym: "glycerol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.22] +xref: EC:1.1.99.22 +xref: MetaCyc:GLYCEROL-DEHYDROGENASE-(ACCEPTOR)-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047956 +name: glycerol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-(NADP+)-RXN] +synonym: "glycerol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.72] +xref: EC:1.1.1.72 +xref: MetaCyc:GLYCEROL-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047957 +name: 4'-methoxyisoflavone 2'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.13.53, MetaCyc:ISOFLAVONE-2'-HYDROXYLASE-RXN] +synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.13.53] +synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.53] +xref: EC:1.14.13.53 +xref: MetaCyc:ISOFLAVONE-2'-HYDROXYLASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047958 +name: glycine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN] +synonym: "glutamate-glyoxylate transaminase activity" EXACT [] +synonym: "glutamic-glyoxylic transaminase activity" EXACT [EC:2.6.1.4] +synonym: "glycine aminotransferase activity" EXACT [] +synonym: "glycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.4] +synonym: "glyoxylate-glutamate aminotransferase activity" EXACT [EC:2.6.1.4] +synonym: "glyoxylate-glutamic transaminase activity" EXACT [EC:2.6.1.4] +synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT [] +xref: EC:2.6.1.4 +xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047959 +name: glycine dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-(CYTOCHROME)-RXN] +synonym: "glycine-cytochrome c reductase activity" EXACT [EC:1.4.2.1] +synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.2.1] +synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1] +xref: EC:1.4.2.1 +xref: MetaCyc:GLYCINE-DEHYDROGENASE-(CYTOCHROME)-RXN +is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor + +[Term] +id: GO:0047960 +name: glycine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN] +synonym: "glycine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.10] +xref: EC:1.4.1.10 +xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047961 +name: glycine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.13] +synonym: "glycine acyltransferase activity" EXACT [EC:2.3.1.13] +synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13] +xref: EC:2.3.1.13 +xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0047962 +name: glycine N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + glycine = CoA + N-benzoylglycine." [EC:2.3.1.71, MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN] +synonym: "benzoyl CoA-amino acid N-acyltransferase activity" EXACT [EC:2.3.1.71] +synonym: "benzoyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.71] +synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" EXACT [EC:2.3.1.71] +xref: EC:2.3.1.71 +xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047963 +name: glycine N-choloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN] +synonym: "amino acid N-choloyltransferase activity" EXACT [EC:2.3.1.65] +synonym: "BACAT activity" EXACT [EC:2.3.1.65] +synonym: "BAT activity" EXACT [EC:2.3.1.65] +synonym: "bile acid-CoA:amino acid N-acyltransferase activity" EXACT [EC:2.3.1.65] +synonym: "choloyl-CoA:glycine N-choloyltransferase activity" EXACT [EC:2.3.1.65] +synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] +synonym: "cholyl-CoA:taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] +synonym: "glycine--taurine N-acyltransferase activity" EXACT [EC:2.3.1.65] +xref: EC:2.3.1.65 +xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0047964 +name: glyoxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "glycolate reductase activity" EXACT [] +synonym: "glyoxylic acid reductase activity" EXACT [EC:1.1.1.26] +synonym: "NADH-dependent glyoxylate reductase activity" EXACT [EC:1.1.1.26] +xref: EC:1.1.1.26 +xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047965 +name: glycoprotein O-fatty-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN] +synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" EXACT [EC:2.3.1.142] +synonym: "protein acyltransferase activity" EXACT [EC:2.3.1.142] +xref: EC:2.3.1.142 +xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN +is_a: GO:0016416 ! O-palmitoyltransferase activity + +[Term] +id: GO:0047966 +name: glycosulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + SO4(2-) (sulfate)." [EC:3.1.6.3, MetaCyc:GLYCOSULFATASE-RXN] +synonym: "glucosulfatase activity" EXACT [EC:3.1.6.3] +synonym: "glycosulphatase activity" EXACT [] +synonym: "sugar-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.3] +xref: EC:3.1.6.3 +xref: MetaCyc:GLYCOSULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047967 +name: glycyrrhizinate beta-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + glycyrrhizinate = 1,2-beta-D-glucuronosyl-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN] +synonym: "glycyrrhizin beta-hydrolase activity" EXACT [EC:3.2.1.128] +synonym: "glycyrrhizin hydrolase activity" EXACT [EC:3.2.1.128] +synonym: "glycyrrhizinate b-glucuronidase activity" EXACT [] +synonym: "glycyrrhizinate glucuronosylhydrolase activity" EXACT [EC:3.2.1.128] +synonym: "glycyrrhizinic acid hydrolase activity" EXACT [EC:3.2.1.128] +xref: EC:3.2.1.128 +xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047968 +name: glyoxylate dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + CoA + NADP+ = oxalyl-CoA + NADPH." [EC:1.2.1.17, MetaCyc:GLYOXYLATE-DEHYDROGENASE-(ACYLATING)-RXN] +synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" EXACT [EC:1.2.1.17] +xref: EC:1.2.1.17 +xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-(ACYLATING)-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047969 +name: glyoxylate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + H2O + O2 = oxalate + H2O2." [EC:1.2.3.5, MetaCyc:GLYOXYLATE-OXIDASE-RXN] +synonym: "glyoxylate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.5] +xref: EC:1.2.3.5 +xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0047970 +name: guanidinoacetase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea." [EC:3.5.3.2, MetaCyc:GUANIDINOACETASE-RXN] +synonym: "glycocyaminase activity" EXACT [EC:3.5.3.2] +synonym: "guanidinoacetate amidinohydrolase activity" EXACT [EC:3.5.3.2] +xref: EC:3.5.3.2 +xref: MetaCyc:GUANIDINOACETASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047971 +name: guanidinobutyrase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea." [EC:3.5.3.7, MetaCyc:GUANIDINOBUTYRASE-RXN] +subset: gosubset_prok +synonym: "4-guanidinobutanoate amidinohydrolase activity" EXACT [EC:3.5.3.7] +synonym: "4-guanidinobutyrate amidinobutyrase activity" EXACT [EC:3.5.3.7] +synonym: "G-base activity" EXACT [EC:3.5.3.7] +synonym: "gamma-guanidinobutyrate amidinohydrolase activity" EXACT [EC:3.5.3.7] +synonym: "gamma-guanidobutyrase activity" EXACT [EC:3.5.3.7] +synonym: "GBH" RELATED [EC:3.5.3.7] +synonym: "guanidinobutyrate ureahydrolase activity" EXACT [EC:3.5.3.7] +xref: EC:3.5.3.7 +xref: MetaCyc:GUANIDINOBUTYRASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047972 +name: guanidinopropionase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea." [EC:3.5.3.17, MetaCyc:GUANIDINOPROPIONASE-RXN] +synonym: "3-guanidinopropanoate amidinopropionase activity" EXACT [EC:3.5.3.17] +synonym: "GPase activity" EXACT [EC:3.5.3.17] +synonym: "GPH" RELATED [EC:3.5.3.17] +xref: EC:3.5.3.17 +xref: MetaCyc:GUANIDINOPROPIONASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047973 +name: guanidinoacetate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + phosphoguanidinoacetate." [EC:2.7.3.1, MetaCyc:GUANIDOACETATE-KINASE-RXN] +synonym: "ATP:guanidinoacetate N-phosphotransferase activity" EXACT [EC:2.7.3.1] +synonym: "glycocyamine kinase activity" EXACT [EC:2.7.3.1] +synonym: "guanidoacetate kinase activity" EXACT [] +xref: EC:2.7.3.1 +xref: MetaCyc:GUANIDOACETATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047974 +name: guanosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN] +synonym: "guanosine aminase activity" EXACT [EC:3.5.4.15] +synonym: "guanosine aminohydrolase activity" EXACT [EC:3.5.4.15] +xref: EC:3.5.4.15 +xref: MetaCyc:GUANOSINE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047975 +name: guanosine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN] +synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.15] +synonym: "guanosine:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.15] +xref: EC:2.4.2.15 +xref: MetaCyc:GUANPHOSPHOR-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0047976 +name: hamamelose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate." [EC:2.7.1.102, MetaCyc:HAMAMELOSE-KINASE-RXN] +synonym: "ATP/hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] +synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102] +synonym: "hamamelose kinase (phosphorylating)" EXACT [EC:2.7.1.102] +synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" EXACT [EC:2.7.1.102] +xref: EC:2.7.1.102 +xref: MetaCyc:HAMAMELOSE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047977 +name: hepoxilin-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN] +synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" EXACT [EC:3.3.2.7] +synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7] +synonym: "hepoxilin A3 hydrolase activity" EXACT [EC:3.3.2.7] +synonym: "hepoxilin epoxide hydrolase activity" EXACT [EC:3.3.2.7] +synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7] +xref: EC:3.3.2.7 +xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0047978 +name: hexadecanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN] +synonym: "hexadecanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.164] +xref: EC:1.1.1.164 +xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047979 +name: hexose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN] +synonym: "D-hexose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.5] +xref: EC:1.1.3.5 +xref: MetaCyc:HEXOSE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047980 +name: hippurate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: hippurate + H2O = benzoate + glycine." [EC:3.5.1.32, MetaCyc:HIPPURATE-HYDROLASE-RXN] +subset: gosubset_prok +synonym: "benzoylglycine amidohydrolase activity" EXACT [EC:3.5.1.32] +synonym: "hippuricase activity" EXACT [EC:3.5.1.32] +synonym: "N-benzoylamino-acid amidohydrolase activity" EXACT [EC:3.5.1.32] +xref: EC:3.5.1.32 +xref: MetaCyc:HIPPURATE-HYDROLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047981 +name: histidine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-histidine = CoA + N-acetyl-L-histidine." [EC:2.3.1.33, MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" EXACT [EC:2.3.1.33] +synonym: "acetylhistidine synthetase activity" EXACT [EC:2.3.1.33] +synonym: "histidine acetyltransferase activity" EXACT [EC:2.3.1.33] +xref: EC:2.3.1.33 +xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047982 +name: homocysteine desulfhydrase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN] +synonym: "homocysteine desulfurase activity" EXACT [EC:4.4.1.2] +synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" EXACT [EC:4.4.1.2] +synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.2] +xref: EC:4.4.1.2 +xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047983 +name: homoglutathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + beta-alanine = ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine." [EC:6.3.2.23, MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN] +synonym: "beta-alanine specific hGSH synthetase activity" EXACT [EC:6.3.2.23] +synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.23] +synonym: "homoglutathione synthetase activity" EXACT [EC:6.3.2.23] +xref: EC:6.3.2.23 +xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047985 +name: hydrogen dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2] +synonym: "H(2):NAD(+) oxidoreductase activity" EXACT [EC:1.12.1.2] +synonym: "H2:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] +synonym: "hydrogen:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2] +synonym: "hydrogenase activity" BROAD [EC:1.12.1.2] +synonym: "NAD-linked hydrogenase activity" EXACT [EC:1.12.1.2] +xref: EC:1.12.1.2 +xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN +is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor + +[Term] +id: GO:0047986 +name: hydrogen-sulfide S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + hydrogen sulfide = CoA + thioacetate." [EC:2.3.1.10, MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" EXACT [EC:2.3.1.10] +synonym: "hydrogen-sulfide acetyltransferase activity" EXACT [EC:2.3.1.10] +synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT [] +xref: EC:2.3.1.10 +xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0047987 +name: hydroperoxide dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O." [EC:4.2.1.92, MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN] +synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] +synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" EXACT [EC:4.2.1.92] +synonym: "HPI" RELATED [EC:4.2.1.92] +synonym: "hydroperoxide isomerase activity" EXACT [EC:4.2.1.92] +synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] +synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] +xref: EC:4.2.1.92 +xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047988 +name: hydroxyacid-oxoacid transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] +synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" EXACT [EC:1.1.99.24] +synonym: "transhydrogenase, hydroxy acid-oxo acid" EXACT [EC:1.1.99.24] +xref: EC:1.1.99.24 +xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047989 +name: hydroxybutyrate-dimer hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate." [EC:3.1.1.22, MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN] +subset: gosubset_prok +synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" EXACT [EC:3.1.1.22] +synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" EXACT [EC:3.1.1.22] +xref: EC:3.1.1.22 +xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0047990 +name: hydroxyglutamate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-L-glutamate = 4-amino-3-hydroxybutanoate + CO2." [EC:4.1.1.16, MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN] +synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" EXACT [EC:4.1.1.16] +synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.16] +xref: EC:4.1.1.16 +xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047991 +name: hydroxylamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxylamine + O2 = NO2(-) (nitrite) + H2O." [EC:1.7.3.4, MetaCyc:HYDROXYLAMINE-OXIDASE-RXN] +subset: gosubset_prok +synonym: "HAO" RELATED [EC:1.7.3.4] +synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.4] +synonym: "hydroxylamine:oxygen oxidoreductase activity" EXACT [EC:1.7.3.4] +xref: EC:1.7.3.4 +xref: MetaCyc:HYDROXYLAMINE-OXIDASE-RXN +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0047992 +name: hydroxylysine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine." [EC:2.7.1.81, MetaCyc:HYDROXYLYSINE-KINASE-RXN] +synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] +synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81] +synonym: "hydroxylysine kinase (phosphorylating)" EXACT [EC:2.7.1.81] +xref: EC:2.7.1.81 +xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047993 +name: hydroxymalonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymalonate + NAD+ = oxomalonate + NADH." [EC:1.1.1.167, MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN] +synonym: "hydroxymalonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.167] +xref: EC:1.1.1.167 +xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047994 +name: hydroxymethylglutaryl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate." [EC:3.1.2.5, MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] +synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5] +synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] +synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] +synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5] +synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5] +xref: EC:3.1.2.5 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047995 +name: hydroxyphenylpyruvate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN] +synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.237] +synonym: "HPRP" RELATED [EC:1.1.1.237] +xref: EC:1.1.1.237 +xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047996 +name: hydroxyphytanate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2." [EC:1.1.3.27, MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN] +synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27] +xref: EC:1.1.3.27 +xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047997 +name: hydroxypyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxypyruvate = glycolaldehyde + CO2." [EC:4.1.1.40, MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN] +synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" EXACT [EC:4.1.1.40] +synonym: "hydroxypyruvate carboxy-lyase activity" EXACT [EC:4.1.1.40] +xref: EC:4.1.1.40 +xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047998 +name: hyoscyamine (6S)-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2." [EC:1.14.11.11, MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN] +synonym: "hyoscyamine (6S)-hydroxylase activity" EXACT [EC:1.14.11.11] +synonym: "hyoscyamine 6-beta-hydroxylase activity" EXACT [EC:1.14.11.11] +synonym: "hyoscyamine 6-hydroxylase activity" EXACT [EC:1.14.11.11] +synonym: "hyoscyamine 6beta-dioxygenase activity" EXACT [EC:1.14.11.11] +synonym: "hyoscyamine 6beta-hydroxylase activity" EXACT [EC:1.14.11.11] +synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" EXACT [EC:1.14.11.11] +xref: EC:1.14.11.11 +xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0047999 +name: hyponitrite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = hyponitrous acid + 2 NADH + 2 H+." [EC:1.7.1.5, MetaCyc:HYPONITRITE-REDUCTASE-RXN] +synonym: "hydroxylamine:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.5] +synonym: "NADH2:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] +synonym: "NADH:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5] +xref: EC:1.7.1.5 +xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0048000 +name: isoflavone 3'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.13.52, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN] +synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.52] +synonym: "isoflavone 3'-monooxygenase activity" EXACT [EC:1.14.13.52] +xref: EC:1.14.13.52 +xref: MetaCyc:RXN-3762 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0048001 +name: erythrose-4-phosphate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0033724 +def: "Catalysis of the reaction: D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH + 2 H+." [EC:1.2.1.72, MetaCyc:ERYTH4PDEHYDROG-RXN] +synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.72] +synonym: "E4P dehydrogenase activity" EXACT [EC:1.2.1.72] +synonym: "E4PDH" EXACT [EC:1.2.1.72] +synonym: "Epd dehydrogenase activity" EXACT [EC:1.2.1.72] +synonym: "erythrose 4-phosphate dehydrogenase activity" EXACT [EC:1.2.1.72] +synonym: "GapB" RELATED [EC:1.2.1.72] +xref: EC:1.2.1.72 +xref: MetaCyc:ERYTH4PDEHYDROG-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0048002 +name: antigen processing and presentation of peptide antigen +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] +synonym: "antigen presentation, peptide antigen" EXACT [] +synonym: "peptide antigen processing and presentation" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0048003 +name: antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] +synonym: "antigen presentation, lipid antigen" EXACT [] +synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0048006 +name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] +synonym: "antigen presentation, endogenous lipid antigen" EXACT [] +synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen +is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0048007 +name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib +namespace: biological_process +def: "The process by which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] +synonym: "antigen presentation, exogenous peptide antigen" EXACT [] +synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen +is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0048008 +name: platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "PDGF receptor signaling pathway" EXACT [] +synonym: "PDGF receptor signalling pathway" EXACT [] +synonym: "PDGFR signaling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048009 +name: insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "IGF receptor signaling pathway" EXACT [] +synonym: "IGF receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048010 +name: vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "VEGF receptor signaling pathway" EXACT [] +synonym: "VEGF receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048011 +name: nerve growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "nerve growth factor receptor signalling pathway" EXACT [] +synonym: "NGF receptor signaling pathway" EXACT [] +synonym: "NGF receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048012 +name: hepatocyte growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "HGF receptor signaling pathway" EXACT [] +synonym: "HGF receptor signalling pathway" EXACT [] +synonym: "Met signaling pathway" NARROW [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048013 +name: ephrin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb] +synonym: "Eph receptor signaling pathway" EXACT [] +synonym: "Eph receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048014 +name: Tie receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a Tie receptor binding to one of its physiological ligands (angiopoietins)." [GOC:ceb] +synonym: "Tek receptor signaling" EXACT [] +synonym: "Tie receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048015 +name: phosphoinositide-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response." [GOC:ceb, PMID:11331907] +subset: gosubset_prok +synonym: "inositol phospholipid-mediated signaling" BROAD [] +synonym: "phosphoinositide-mediated signalling" EXACT [] +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0048016 +name: inositol phosphate-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert an extracellular signal into a response." [GOC:ceb] +synonym: "inositol phosphate-mediated signalling" EXACT [] +synonym: "inositol phospholipid-mediated signaling" BROAD [] +is_a: GO:0048015 ! phosphoinositide-mediated signaling + +[Term] +id: GO:0048017 +name: inositol lipid-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses an inositol lipid to convert an extracellular signal into a response." [GOC:ceb, PMID:11331907] +synonym: "inositol lipid-mediated signalling" EXACT [] +synonym: "inositol phospholipid-mediated signaling" BROAD [] +is_a: GO:0048015 ! phosphoinositide-mediated signaling + +[Term] +id: GO:0048018 +name: receptor agonist activity +namespace: molecular_function +def: "Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005102 ! receptor binding +is_a: GO:0030546 ! receptor activator activity + +[Term] +id: GO:0048019 +name: receptor antagonist activity +namespace: molecular_function +def: "Interacts with receptors to reduce the action of another ligand, the agonist." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0005102 ! receptor binding +is_a: GO:0030547 ! receptor inhibitor activity + +[Term] +id: GO:0048020 +name: CCR chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a CCR chemokine receptor." [GOC:ai] +synonym: "beta chemokine receptor binding" EXACT [] +synonym: "beta chemokine receptor ligand" NARROW [] +synonym: "CCR chemokine receptor ligand" NARROW [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0048021 +name: regulation of melanin biosynthetic process +namespace: biological_process +def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jic] +subset: gosubset_prok +synonym: "regulation of melanin anabolism" EXACT [] +synonym: "regulation of melanin biosynthesis" EXACT [] +synonym: "regulation of melanin formation" EXACT [] +synonym: "regulation of melanin synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0048022 +name: negative regulation of melanin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jic] +subset: gosubset_prok +synonym: "down regulation of melanin biosynthetic process" EXACT [] +synonym: "down-regulation of melanin biosynthetic process" EXACT [] +synonym: "downregulation of melanin biosynthetic process" EXACT [] +synonym: "inhibition of melanin biosynthetic process" NARROW [] +synonym: "negative regulation of melanin anabolism" EXACT [] +synonym: "negative regulation of melanin biosynthesis" EXACT [] +synonym: "negative regulation of melanin formation" EXACT [] +synonym: "negative regulation of melanin synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0048021 ! regulation of melanin biosynthetic process +relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0048023 +name: positive regulation of melanin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jic] +subset: gosubset_prok +synonym: "activation of melanin biosynthetic process" NARROW [] +synonym: "positive regulation of melanin anabolism" EXACT [] +synonym: "positive regulation of melanin biosynthesis" EXACT [] +synonym: "positive regulation of melanin formation" EXACT [] +synonym: "positive regulation of melanin synthesis" EXACT [] +synonym: "stimulation of melanin biosynthetic process" NARROW [] +synonym: "up regulation of melanin biosynthetic process" EXACT [] +synonym: "up-regulation of melanin biosynthetic process" EXACT [] +synonym: "upregulation of melanin biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0048021 ! regulation of melanin biosynthetic process +relationship: positively_regulates GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0048024 +name: regulation of nuclear mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0035055 +def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jic] +synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "regulation of pre-mRNA splicing" BROAD [] +is_a: GO:0043484 ! regulation of RNA splicing +is_a: GO:0050684 ! regulation of mRNA processing +relationship: regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0048025 +name: negative regulation of nuclear mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0035056 +def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jic] +synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW [] +synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "negative regulation of pre-mRNA splicing" BROAD [] +is_a: GO:0033119 ! negative regulation of RNA splicing +is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome +is_a: GO:0050686 ! negative regulation of mRNA processing +relationship: negatively_regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0048026 +name: positive regulation of nuclear mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0035057 +def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jic] +synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW [] +synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "positive regulation of pre-mRNA splicing" BROAD [] +synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW [] +synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT [] +is_a: GO:0033120 ! positive regulation of RNA splicing +is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome +is_a: GO:0050685 ! positive regulation of mRNA processing +relationship: positively_regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome + +[Term] +id: GO:0048027 +name: mRNA 5'-UTR binding +namespace: molecular_function +def: "Interacting selectively with the 5' untranslated region of an mRNA molecule." [GOC:jic] +subset: gosubset_prok +synonym: "mRNA 5' UTR binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0048028 +name: galacturonan binding +namespace: molecular_function +def: "Interacting selectively with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jic] +subset: gosubset_prok +synonym: "polygalacturonide binding" RELATED [] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0048029 +name: monosaccharide binding +namespace: molecular_function +def: "Interacting selectively with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ChEBI:35381, GOC:jic] +subset: gosubset_prok +is_a: GO:0005529 ! sugar binding + +[Term] +id: GO:0048030 +name: disaccharide binding +namespace: molecular_function +def: "Interacting selectively with any disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jic] +is_a: GO:0005529 ! sugar binding + +[Term] +id: GO:0048031 +name: trisaccharide binding +namespace: molecular_function +def: "Interacting selectively with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jic] +is_a: GO:0005529 ! sugar binding + +[Term] +id: GO:0048032 +name: galacturonate binding +namespace: molecular_function +def: "Interacting selectively with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ChEBI:33812, GOC:jic] +synonym: "galacturonic acid binding" EXACT [] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0048033 +name: heme o metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jic] +subset: gosubset_prok +synonym: "haem o metabolic process" EXACT [] +synonym: "haem o metabolism" EXACT [] +synonym: "heme o metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0048034 +name: heme O biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jic] +subset: gosubset_prok +synonym: "haem O biosynthesis" EXACT [] +synonym: "haem O biosynthetic process" EXACT [] +synonym: "heme O anabolism" EXACT [] +synonym: "heme O biosynthesis" EXACT [] +synonym: "heme O formation" EXACT [] +synonym: "heme O synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0048033 ! heme o metabolic process + +[Term] +id: GO:0048035 +name: heme o catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jic] +subset: gosubset_prok +synonym: "haem o catabolic process" EXACT [] +synonym: "haem o catabolism" EXACT [] +synonym: "heme o breakdown" EXACT [] +synonym: "heme o catabolism" EXACT [] +synonym: "heme o degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0048033 ! heme o metabolic process + +[Term] +id: GO:0048036 +name: central complex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] +synonym: "central body development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0048037 +name: cofactor binding +namespace: molecular_function +def: "Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0048038 +name: quinone binding +namespace: molecular_function +def: "Interacting selectively with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0048037 ! cofactor binding + +[Term] +id: GO:0048039 +name: ubiquinone binding +namespace: molecular_function +def: "Interacting selectively with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jic, ISBN:0582227089] +subset: gosubset_prok +synonym: "coenzyme Q binding" EXACT [] +synonym: "coenzyme Q6 binding" NARROW [] +is_a: GO:0048038 ! quinone binding + +[Term] +id: GO:0048040 +name: UDP-glucuronate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucuronic acid = UDP-D-xylose + CO2." [EC:4.1.1.35, PMID:11593010] +synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" EXACT [EC:4.1.1.35] +synonym: "UDP-D-glucuronate carboxy-lyase activity" EXACT [EC:4.1.1.35] +synonym: "UDP-glucuronic acid decarboxylase activity" EXACT [] +synonym: "UDPglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] +synonym: "uridine-diphosphoglucuronate decarboxylase activity" EXACT [EC:4.1.1.35] +xref: EC:4.1.1.35 +xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0048041 +name: focal adhesion formation +namespace: biological_process +def: "Establishment and maturation of focal adhesions, complexes of intracellular signaling and structural proteins which provide a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jic] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0048042 +name: regulation of oviposition, post-mating +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of egg-laying, following mating." [PMID:11932766] +is_a: GO:0046662 ! regulation of oviposition +relationship: part_of GO:0045297 ! post-mating behavior + +[Term] +id: GO:0048045 +name: trans-pentaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.33] +subset: gosubset_prok +synonym: "all-trans-hexaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.33] +synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" EXACT [EC:2.5.1.33] +synonym: "hexaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.33] +synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT [] +xref: EC:2.5.1.33 +xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0048046 +name: apoplast +namespace: cellular_component +def: "The protoplasts of cells in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jic] +is_a: GO:0005576 ! extracellular region + +[Term] +id: GO:0048047 +name: mating behavior, sex discrimination +namespace: biological_process +def: "The actions or reactions of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jic, PMID:12486700] +synonym: "mating behaviour, sex discrimination" EXACT [] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0048048 +name: embryonic eye morphogenesis +namespace: biological_process +def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0048562 ! embryonic organ morphogenesis +is_a: GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0048050 +name: post-embryonic eye morphogenesis +namespace: biological_process +alt_id: GO:0048051 +def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The eye is the organ of sight." [GOC:jic, GOC:sensu] +synonym: "post-embryonic eye morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0048563 ! post-embryonic organ morphogenesis +is_a: GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0048052 +name: R1/R6 cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors." [GOC:jic] +synonym: "R1/R6 cell differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0048053 +name: R1/R6 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres." [GOC:jic] +synonym: "R1/R6 development (sensu Endopterygota)" EXACT [] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0048052 ! R1/R6 cell differentiation + +[Term] +id: GO:0048054 +name: R2/R5 cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors." [GOC:jic] +synonym: "R2/R5 cell differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0048055 +name: R2/R5 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres." [GOC:jic] +synonym: "R2/R5 development (sensu Endopterygota)" EXACT [] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0048054 ! R2/R5 cell differentiation + +[Term] +id: GO:0048056 +name: R3/R4 cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors." [GOC:jic] +synonym: "R3/R4 cell differentiation (sensu Endopterygota)" EXACT [] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0048057 +name: R3/R4 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres." [GOC:jic] +synonym: "R3/R4 development (sensu Endopterygota)" EXACT [] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0048056 ! R3/R4 cell differentiation + +[Term] +id: GO:0048058 +name: compound eye corneal lens development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jic] +synonym: "corneal lens development (sensu Endopterygota)" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048749 ! compound eye development + +[Term] +id: GO:0048060 +name: negative gravitaxis +namespace: biological_process +alt_id: GO:0048063 +def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jic] +synonym: "negative geotactic behavior" EXACT [] +synonym: "negative geotactic behaviour" EXACT [] +synonym: "negative gravitactic behavior" EXACT [] +synonym: "negative gravitactic behaviour" EXACT [] +synonym: "negative taxis in response to gravity" EXACT [] +synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] +is_a: GO:0042332 ! gravitaxis + +[Term] +id: GO:0048061 +name: positive gravitaxis +namespace: biological_process +alt_id: GO:0048064 +def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jic] +synonym: "positive geotactic behavior" EXACT [] +synonym: "positive geotactic behaviour" EXACT [] +synonym: "positive gravitactic behavior" EXACT [] +synonym: "positive gravitactic behaviour" EXACT [] +synonym: "positive taxis in response to gravity" EXACT [] +synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] +is_a: GO:0042332 ! gravitaxis + +[Term] +id: GO:0048065 +name: male courtship behavior, veined wing extension +namespace: biological_process +def: "The process during courtship where the male insect extends his wings." [GOC:jic, GOC:mtg_sensu] +synonym: "male courtship behavior (sensu Insecta), wing extension" EXACT [] +synonym: "male courtship behaviour (sensu Insecta), wing extension" EXACT [] +synonym: "male courtship behaviour, veined wing extension" EXACT [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0048066 +name: pigmentation during development +namespace: biological_process +def: "The deposition of coloring matter in an organism, tissue or cell, occurring during development." [ISBN:0582227089] +subset: gosubset_prok +synonym: "developmental pigmentation" EXACT [] +is_a: GO:0032502 ! developmental process +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0048067 +name: cuticle pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic] +is_a: GO:0048066 ! pigmentation during development +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0048069 +name: eye pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jic] +is_a: GO:0048066 ! pigmentation during development + +[Term] +id: GO:0048070 +name: regulation of pigmentation during development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the deposition of coloring matter occurring during development." [GOC:jic, GOC:tb] +synonym: "regulation of developmental pigmentation" EXACT [GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048066 ! pigmentation during development + +[Term] +id: GO:0048071 +name: sex-specific pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jic] +is_a: GO:0048066 ! pigmentation during development +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0048072 +name: compound eye pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in the compound eye." [GOC:jic] +synonym: "eye pigmentation (sensu Endopterygota)" EXACT [] +is_a: GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048073 +name: regulation of eye pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jic] +is_a: GO:0048070 ! regulation of pigmentation during development +relationship: regulates GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048074 +name: negative regulation of eye pigmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jic] +synonym: "down regulation of eye pigmentation" EXACT [] +synonym: "down-regulation of eye pigmentation" EXACT [] +synonym: "downregulation of eye pigmentation" EXACT [] +synonym: "inhibition of eye pigmentation" NARROW [] +is_a: GO:0048073 ! regulation of eye pigmentation +is_a: GO:0048086 ! negative regulation of pigmentation during development +relationship: negatively_regulates GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048075 +name: positive regulation of eye pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jic] +synonym: "activation of eye pigmentation" NARROW [] +synonym: "stimulation of eye pigmentation" NARROW [] +synonym: "up regulation of eye pigmentation" EXACT [] +synonym: "up-regulation of eye pigmentation" EXACT [] +synonym: "upregulation of eye pigmentation" EXACT [] +is_a: GO:0048073 ! regulation of eye pigmentation +is_a: GO:0048087 ! positive regulation of pigmentation during development +relationship: positively_regulates GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048076 +name: regulation of compound eye pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jic] +synonym: "regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +is_a: GO:0048073 ! regulation of eye pigmentation +relationship: regulates GO:0048072 ! compound eye pigmentation + +[Term] +id: GO:0048077 +name: negative regulation of compound eye pigmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jic] +synonym: "down regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +synonym: "down-regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +synonym: "downregulation of eye pigmentation (sensu Endopterygota)" EXACT [] +synonym: "inhibition of eye pigmentation (sensu Endopterygota)" NARROW [] +synonym: "negative regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +is_a: GO:0048074 ! negative regulation of eye pigmentation +is_a: GO:0048076 ! regulation of compound eye pigmentation +relationship: negatively_regulates GO:0048072 ! compound eye pigmentation + +[Term] +id: GO:0048078 +name: positive regulation of compound eye pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jic] +synonym: "activation of eye pigmentation (sensu Endopterygota)" NARROW [] +synonym: "positive regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +synonym: "stimulation of eye pigmentation (sensu Endopterygota)" NARROW [] +synonym: "up regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +synonym: "up-regulation of eye pigmentation (sensu Endopterygota)" EXACT [] +synonym: "upregulation of eye pigmentation (sensu Endopterygota)" EXACT [] +is_a: GO:0048075 ! positive regulation of eye pigmentation +is_a: GO:0048076 ! regulation of compound eye pigmentation +relationship: positively_regulates GO:0048072 ! compound eye pigmentation + +[Term] +id: GO:0048079 +name: regulation of cuticle pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic] +is_a: GO:0048070 ! regulation of pigmentation during development +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048067 ! cuticle pigmentation + +[Term] +id: GO:0048080 +name: negative regulation of cuticle pigmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic] +synonym: "down regulation of cuticle pigmentation" EXACT [] +synonym: "down-regulation of cuticle pigmentation" EXACT [] +synonym: "downregulation of cuticle pigmentation" EXACT [] +synonym: "inhibition of cuticle pigmentation" NARROW [] +is_a: GO:0048079 ! regulation of cuticle pigmentation +is_a: GO:0048086 ! negative regulation of pigmentation during development +relationship: negatively_regulates GO:0048067 ! cuticle pigmentation + +[Term] +id: GO:0048081 +name: positive regulation of cuticle pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic] +synonym: "activation of cuticle pigmentation" NARROW [] +synonym: "stimulation of cuticle pigmentation" NARROW [] +synonym: "up regulation of cuticle pigmentation" EXACT [] +synonym: "up-regulation of cuticle pigmentation" EXACT [] +synonym: "upregulation of cuticle pigmentation" EXACT [] +is_a: GO:0048079 ! regulation of cuticle pigmentation +is_a: GO:0048087 ! positive regulation of pigmentation during development +relationship: positively_regulates GO:0048067 ! cuticle pigmentation + +[Term] +id: GO:0048082 +name: regulation of adult chitin-containing cuticle pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jic, GOC:mtg_sensu] +is_a: GO:0007564 ! regulation of chitin-based cuticle tanning +is_a: GO:0048079 ! regulation of cuticle pigmentation +relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation + +[Term] +id: GO:0048083 +name: negative regulation of adult chitin-containing cuticle pigmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jic, GOC:mtg_sensu] +synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW [] +is_a: GO:0048080 ! negative regulation of cuticle pigmentation +is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation +relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation + +[Term] +id: GO:0048084 +name: positive regulation of adult chitin-containing cuticle pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jic, GOC:mtg_sensu] +synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW [] +synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW [] +synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT [] +is_a: GO:0048081 ! positive regulation of cuticle pigmentation +is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation +relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation + +[Term] +id: GO:0048085 +name: adult chitin-containing cuticle pigmentation +namespace: biological_process +alt_id: GO:0048068 +def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:jic, GOC:mtg_sensu] +synonym: "adult cuticle pigmentation (sensu Insecta)" EXACT [] +is_a: GO:0048067 ! cuticle pigmentation +relationship: part_of GO:0007593 ! chitin-based cuticle tanning + +[Term] +id: GO:0048086 +name: negative regulation of pigmentation during development +namespace: biological_process +def: "Any process that stops, prevents or reduces the deposition of coloring matter occurring during development." [GOC:dph, GOC:jic, GOC:tb] +synonym: "down regulation of pigmentation" EXACT [] +synonym: "down-regulation of pigmentation" EXACT [] +synonym: "downregulation of pigmentation" EXACT [] +synonym: "inhibition of pigmentation" NARROW [] +is_a: GO:0048070 ! regulation of pigmentation during development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0048066 ! pigmentation during development + +[Term] +id: GO:0048087 +name: positive regulation of pigmentation during development +namespace: biological_process +def: "Any process that activates or increases the deposition of coloring matter occurring during development." [GOC:dph, GOC:jic, GOC:tb] +synonym: "activation of pigmentation" NARROW [] +synonym: "stimulation of pigmentation" NARROW [] +synonym: "up regulation of pigmentation" EXACT [] +synonym: "up-regulation of pigmentation" EXACT [] +synonym: "upregulation of pigmentation" EXACT [] +is_a: GO:0048070 ! regulation of pigmentation during development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0048066 ! pigmentation during development + +[Term] +id: GO:0048088 +name: regulation of male pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jic] +is_a: GO:0048070 ! regulation of pigmentation during development +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048094 ! male pigmentation + +[Term] +id: GO:0048089 +name: regulation of female pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jic] +is_a: GO:0048070 ! regulation of pigmentation during development +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048095 ! female pigmentation + +[Term] +id: GO:0048090 +name: negative regulation of female pigmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jic] +synonym: "down regulation of female pigmentation" EXACT [] +synonym: "down-regulation of female pigmentation" EXACT [] +synonym: "downregulation of female pigmentation" EXACT [] +synonym: "inhibition of female pigmentation" NARROW [] +is_a: GO:0048086 ! negative regulation of pigmentation during development +is_a: GO:0048089 ! regulation of female pigmentation +relationship: negatively_regulates GO:0048095 ! female pigmentation + +[Term] +id: GO:0048091 +name: positive regulation of female pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jic] +synonym: "activation of female pigmentation" NARROW [] +synonym: "stimulation of female pigmentation" NARROW [] +synonym: "up regulation of female pigmentation" EXACT [] +synonym: "up-regulation of female pigmentation" EXACT [] +synonym: "upregulation of female pigmentation" EXACT [] +is_a: GO:0048087 ! positive regulation of pigmentation during development +is_a: GO:0048089 ! regulation of female pigmentation +relationship: positively_regulates GO:0048095 ! female pigmentation + +[Term] +id: GO:0048092 +name: negative regulation of male pigmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jic] +synonym: "down regulation of male pigmentation" EXACT [] +synonym: "down-regulation of male pigmentation" EXACT [] +synonym: "downregulation of male pigmentation" EXACT [] +synonym: "inhibition of male pigmentation" NARROW [] +is_a: GO:0048086 ! negative regulation of pigmentation during development +is_a: GO:0048088 ! regulation of male pigmentation +relationship: negatively_regulates GO:0048094 ! male pigmentation + +[Term] +id: GO:0048093 +name: positive regulation of male pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jic] +synonym: "activation of male pigmentation" NARROW [] +synonym: "stimulation of male pigmentation" NARROW [] +synonym: "up regulation of male pigmentation" EXACT [] +synonym: "up-regulation of male pigmentation" EXACT [] +synonym: "upregulation of male pigmentation" EXACT [] +is_a: GO:0048087 ! positive regulation of pigmentation during development +is_a: GO:0048088 ! regulation of male pigmentation +relationship: positively_regulates GO:0048094 ! male pigmentation + +[Term] +id: GO:0048094 +name: male pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in males." [GOC:jic] +is_a: GO:0048071 ! sex-specific pigmentation +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0048095 +name: female pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in females." [GOC:jic] +is_a: GO:0048071 ! sex-specific pigmentation +relationship: part_of GO:0046660 ! female sex differentiation + +[Term] +id: GO:0048096 +name: chromatin-mediated maintenance of transcription +namespace: biological_process +def: "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jic] +comment: Note that this process is the opposite of chromatin silencing. This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. +is_a: GO:0006338 ! chromatin remodeling +is_a: GO:0045815 ! positive regulation of gene expression, epigenetic +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent + +[Term] +id: GO:0048097 +name: long-term maintenance of gene activation +namespace: biological_process +def: "Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jic] +comment: Note that this process is the opposite of gene silencing. +is_a: GO:0045815 ! positive regulation of gene expression, epigenetic + +[Term] +id: GO:0048098 +name: antennal joint development +namespace: biological_process +def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jic] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007469 ! antennal development + +[Term] +id: GO:0048099 +name: anterior/posterior lineage restriction, imaginal disc +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jic, PMID:10625531, PMID:9374402] +is_a: GO:0035161 ! imaginal disc lineage restriction +relationship: part_of GO:0007448 ! anterior/posterior pattern formation, imaginal disc + +[Term] +id: GO:0048100 +name: wing disc anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jic, PMID:10625531] +is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc +is_a: GO:0035222 ! wing disc pattern formation + +[Term] +id: GO:0048101 +name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jic] +synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED [] +synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] +synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT [] +synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] +is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity + +[Term] +id: GO:0048102 +name: autophagic cell death +namespace: biological_process +def: "Destruction of a cell by its own lysosomal contents. This type of programmed cell death is seen when entire tissues, or parts thereof, are committed to destruction, and occurs by the formation of multiple acidic autophagic vacuoles within the doomed cells." [GOC:jic, PMID:11494315] +synonym: "autophagic death (sensu Fungi)" NARROW [] +synonym: "autophagic death (sensu Saccharomyces)" NARROW [] +synonym: "programmed cell death by autophagy" EXACT [] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0048103 +name: somatic stem cell division +namespace: biological_process +def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jic, ISBN:0582227089] +synonym: "somatic stem cell renewal" EXACT [] +is_a: GO:0017145 ! stem cell division + +[Term] +id: GO:0048104 +name: establishment of body hair or bristle orientation +namespace: biological_process +def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction." [GOC:jic] +is_a: GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0048105 +name: establishment of body hair orientation +namespace: biological_process +def: "Orientation of body hairs, actin rich projections emanating from the apical surface of each cell, such that they all point in a uniform direction." [GOC:jic] +is_a: GO:0048104 ! establishment of body hair or bristle orientation + +[Term] +id: GO:0048106 +name: establishment of body bristle orientation +namespace: biological_process +def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [GOC:jic] +is_a: GO:0048104 ! establishment of body hair or bristle orientation +relationship: part_of GO:0008407 ! bristle morphogenesis + +[Term] +id: GO:0048107 +name: 4-amino-3-isothiazolidinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jic] +subset: gosubset_prok +synonym: "4-amino-3-isothiazolidinone anabolism" EXACT [] +synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT [] +synonym: "4-amino-3-isothiazolidinone formation" EXACT [] +synonym: "4-amino-3-isothiazolidinone synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process + +[Term] +id: GO:0048108 +name: peptide cross-linking via 4-amino-3-isothiazolidinone +namespace: biological_process +def: "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jic, GOC:jsg] +comment: Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link. +subset: gosubset_prok +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0048109 +name: peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jic, PMID:12802338, PMID:12802339, RESID:AA0344] +subset: gosubset_prok +xref: RESID:AA0344 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0048108 ! peptide cross-linking via 4-amino-3-isothiazolidinone + +[Term] +id: GO:0048132 +name: female germ-line stem cell division +namespace: biological_process +alt_id: GO:0048141 +def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jic, GOC:mtg_sensu] +synonym: "female germ-line stem cell division (sensu Insecta)" EXACT [] +synonym: "female germ-line stem cell renewal" EXACT [] +synonym: "female germ-line stem cell renewal (sensu Insecta)" RELATED [] +is_a: GO:0042078 ! germ-line stem cell division +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0048133 +name: male germ-line stem cell division +namespace: biological_process +def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jic] +synonym: "male germ-line stem cell renewal" EXACT [] +is_a: GO:0042078 ! germ-line stem cell division +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048134 +name: germ-line cyst formation +namespace: biological_process +def: "Formation of a cluster of germ-line cells derived from a single founder cell." [GOC:jic, PMID:10370240] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0007281 ! germ cell development + +[Term] +id: GO:0048135 +name: female germ-line cyst formation +namespace: biological_process +def: "Formation of a cluster of germ-line cells, in the female gonad, derived from a single founder cell." [GOC:jic] +is_a: GO:0048134 ! germ-line cyst formation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0048136 +name: male germ-line cyst formation +namespace: biological_process +def: "Formation of a cluster of germ-line cells, in the male gonad of an insect, derived from a single founder cell (cystoblast)." [GOC:jic] +is_a: GO:0048134 ! germ-line cyst formation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048137 +name: spermatocyte division +namespace: biological_process +def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce a cyst of haploid spermatids." [GOC:jic, ISBN:0879694238] +synonym: "spermatocyte cell division" EXACT [] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0048136 ! male germ-line cyst formation + +[Term] +id: GO:0048138 +name: germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jic, PMID:11591336] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007276 ! gamete generation +relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium + +[Term] +id: GO:0048139 +name: female germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jic, PMID:11591336] +is_a: GO:0048138 ! germ-line cyst encapsulation +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0048140 +name: male germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jic, PMID:11591336] +is_a: GO:0048138 ! germ-line cyst encapsulation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048142 +name: germarium-derived cystoblast division +namespace: biological_process +def: "The four rounds of incomplete mitosis undergone by a cystoblast derived from the germarium to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells." [GOC:jic, GOC:mtg_sensu, PMID:11131529] +synonym: "cystoblast cell division (sensu Insecta)" EXACT [] +synonym: "cystoblast division (sensu Insecta)" EXACT [] +is_a: GO:0007282 ! cystoblast division +relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation + +[Term] +id: GO:0048143 +name: astrocyte activation +namespace: biological_process +def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0014002 ! astrocyte development + +[Term] +id: GO:0048144 +name: fibroblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jic] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0048145 +name: regulation of fibroblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jic] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0048146 +name: positive regulation of fibroblast proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jic] +synonym: "activation of fibroblast proliferation" NARROW [] +synonym: "stimulation of fibroblast proliferation" NARROW [] +synonym: "up regulation of fibroblast proliferation" EXACT [] +synonym: "up-regulation of fibroblast proliferation" EXACT [] +synonym: "upregulation of fibroblast proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0048145 ! regulation of fibroblast proliferation +relationship: positively_regulates GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0048147 +name: negative regulation of fibroblast proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jic] +synonym: "down regulation of fibroblast proliferation" EXACT [] +synonym: "down-regulation of fibroblast proliferation" EXACT [] +synonym: "downregulation of fibroblast proliferation" EXACT [] +synonym: "inhibition of fibroblast proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0048145 ! regulation of fibroblast proliferation +relationship: negatively_regulates GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0048148 +name: behavioral response to cocaine +namespace: biological_process +def: "A change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jic] +synonym: "behavioural response to cocaine" EXACT [] +synonym: "response to cocaine (sensu Insecta)" RELATED [] +is_a: GO:0030534 ! adult behavior +is_a: GO:0042220 ! response to cocaine + +[Term] +id: GO:0048149 +name: behavioral response to ethanol +namespace: biological_process +def: "A change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jic] +synonym: "behavioural response to ethanol" EXACT [] +synonym: "response to ethanol (sensu Insecta)" RELATED [] +is_a: GO:0030534 ! adult behavior +is_a: GO:0045471 ! response to ethanol + +[Term] +id: GO:0048150 +name: behavioral response to ether +namespace: biological_process +def: "A change in the behavior of an organism as a result of an ether stimulus." [GOC:jic] +synonym: "behavioural response to ether" EXACT [] +synonym: "response to ether (sensu Insecta)" RELATED [] +is_a: GO:0030534 ! adult behavior +is_a: GO:0045472 ! response to ether + +[Term] +id: GO:0048151 +name: hyperphosphorylation +namespace: biological_process +def: "The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jic, ISBN:039751820X, PMID:12859672] +comment: Note that this term should be used only to annotate gene products that carry out hyperphosphorylations that are normal for the cell/organism. +subset: gosubset_prok +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0048152 +name: S100 beta biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] +synonym: "S100 beta anabolism" EXACT [] +synonym: "S100 beta biosynthesis" EXACT [] +synonym: "S100 beta formation" EXACT [] +synonym: "S100 beta synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0048153 +name: S100 alpha biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] +synonym: "S100 alpha anabolism" EXACT [] +synonym: "S100 alpha biosynthesis" EXACT [] +synonym: "S100 alpha formation" EXACT [] +synonym: "S100 alpha synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0048154 +name: S100 beta binding +namespace: molecular_function +def: "Interacting selectively with S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0048155 +name: S100 alpha binding +namespace: molecular_function +def: "Interacting selectively with S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0048156 +name: tau protein binding +namespace: molecular_function +def: "Interacting selectively with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0048158 +name: oogonium stage, oogenesis +namespace: biological_process +def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 1" EXACT [] +synonym: "oogonium stage, oogenesis (sensu Mammalia)" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048159 +name: primary oocyte stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 2" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048160 +name: primary follicle stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 3" EXACT [] +synonym: "primary follicle stage, oogenesis (sensu Mammalia)" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048161 +name: double layer follicle stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "double layer follicle stage, oogenesis (sensu Mammalia)" EXACT [] +synonym: "mammalian oogenesis stage 4" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048162 +name: multi-layer follicle stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 5" EXACT [] +synonym: "multi-layer follicle stage, oogenesis (sensu Mammalia)" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048163 +name: scattered antral spaces stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 6" EXACT [] +synonym: "scattered antral spaces stage, oogenesis (sensu Mammalia)" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048164 +name: distinct antral spaces stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "distinct antral spaces stage, oogenesis (sensu Mammalia)" EXACT [] +synonym: "mammalian oogenesis stage 7" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048165 +name: fused antrum stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "fused antrum stage, oogenesis (sensu Mammalia)" EXACT [] +synonym: "mammalian oogenesis stage 8" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048166 +name: mature follicle stage, oogenesis +namespace: biological_process +def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 9" EXACT [] +synonym: "mature follicle stage, oogenesis (sensu Mammalia)" EXACT [] +is_a: GO:0022605 ! oogenesis stage + +[Term] +id: GO:0048167 +name: regulation of synaptic plasticity +namespace: biological_process +def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jic, GOC:tb, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0050804 ! regulation of synaptic transmission + +[Term] +id: GO:0048168 +name: regulation of neuronal synaptic plasticity +namespace: biological_process +def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0048169 +name: regulation of long-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0048168 ! regulation of neuronal synaptic plasticity + +[Term] +id: GO:0048170 +name: positive regulation of long-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "activation of long-term neuronal synaptic plasticity" NARROW [] +synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW [] +synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT [] +is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity +is_a: GO:0050769 ! positive regulation of neurogenesis + +[Term] +id: GO:0048171 +name: negative regulation of long-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW [] +is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity +is_a: GO:0050768 ! negative regulation of neurogenesis + +[Term] +id: GO:0048172 +name: regulation of short-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0048168 ! regulation of neuronal synaptic plasticity + +[Term] +id: GO:0048173 +name: positive regulation of short-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "activation of short-term neuronal synaptic plasticity" NARROW [] +synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW [] +synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT [] +is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity +is_a: GO:0050769 ! positive regulation of neurogenesis + +[Term] +id: GO:0048174 +name: negative regulation of short-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jic, http://www.mercksource.com, PMID:11891290] +comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW [] +is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity +is_a: GO:0050768 ! negative regulation of neurogenesis + +[Term] +id: GO:0048175 +name: hepatocyte growth factor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hepacyte growth factor. Hepatocyte growth factor is a mitogen for a number of cell types and it is found in liver cells and in many other cell types, including platelets." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "hepatocyte growth factor anabolism" EXACT [] +synonym: "hepatocyte growth factor biosynthesis" EXACT [] +synonym: "hepatocyte growth factor formation" EXACT [] +synonym: "hepatocyte growth factor synthesis" EXACT [] +synonym: "HGF biosynthesis" EXACT [] +synonym: "HGF biosynthetic process" EXACT [] +synonym: "scatter factor biosynthesis" EXACT [] +synonym: "scatter factor biosynthetic process" EXACT [] +is_a: GO:0042089 ! cytokine biosynthetic process +relationship: part_of GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0048176 +name: regulation of hepatocyte growth factor biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "regulation of hepatocyte growth factor anabolism" EXACT [] +synonym: "regulation of hepatocyte growth factor biosynthesis" EXACT [] +synonym: "regulation of hepatocyte growth factor formation" EXACT [] +synonym: "regulation of hepatocyte growth factor synthesis" EXACT [] +synonym: "regulation of HGF biosynthesis" EXACT [] +synonym: "regulation of HGF biosynthetic process" EXACT [] +synonym: "regulation of scatter factor biosynthesis" EXACT [] +synonym: "regulation of scatter factor biosynthetic process" EXACT [] +is_a: GO:0032646 ! regulation of hepatocyte growth factor production +is_a: GO:0042035 ! regulation of cytokine biosynthetic process +relationship: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process + +[Term] +id: GO:0048177 +name: positive regulation of hepatocyte growth factor biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "activation of hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "positive regulation of hepatocyte growth factor anabolism" EXACT [] +synonym: "positive regulation of hepatocyte growth factor biosynthesis" EXACT [] +synonym: "positive regulation of hepatocyte growth factor formation" EXACT [] +synonym: "positive regulation of hepatocyte growth factor synthesis" EXACT [] +synonym: "positive regulation of HGF biosynthesis" EXACT [] +synonym: "positive regulation of HGF biosynthetic process" EXACT [] +synonym: "positive regulation of scatter factor biosynthesis" EXACT [] +synonym: "positive regulation of scatter factor biosynthetic process" EXACT [] +synonym: "stimulation of hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "up regulation of hepatocyte growth factor biosynthetic process" EXACT [] +synonym: "up-regulation of hepatocyte growth factor biosynthetic process" EXACT [] +synonym: "upregulation of hepatocyte growth factor biosynthetic process" EXACT [] +is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process +is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process +relationship: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process + +[Term] +id: GO:0048178 +name: negative regulation of hepatocyte growth factor biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "down regulation of hepatocyte growth factor biosynthetic process" EXACT [] +synonym: "down-regulation of hepatocyte growth factor biosynthetic process" EXACT [] +synonym: "downregulation of hepatocyte growth factor biosynthetic process" EXACT [] +synonym: "inhibition of hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "negative regulation of hepatocyte growth factor anabolism" EXACT [] +synonym: "negative regulation of hepatocyte growth factor biosynthesis" EXACT [] +synonym: "negative regulation of hepatocyte growth factor formation" EXACT [] +synonym: "negative regulation of hepatocyte growth factor synthesis" EXACT [] +synonym: "negative regulation of HGF biosynthesis" EXACT [] +synonym: "negative regulation of HGF biosynthetic process" EXACT [] +synonym: "negative regulation of scatter factor biosynthesis" EXACT [] +synonym: "negative regulation of scatter factor biosynthetic process" EXACT [] +is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process +is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process +relationship: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process + +[Term] +id: GO:0048179 +name: activin receptor complex +namespace: cellular_component +def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0048180 +name: activin complex +namespace: cellular_component +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. +subset: goslim_pir +is_a: GO:0043234 ! protein complex +is_a: GO:0044421 ! extracellular region part +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0048183 +name: activin AB complex +namespace: cellular_component +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. +synonym: "inhibin beta-A" NARROW [] +synonym: "inhibin beta-B" NARROW [] +is_a: GO:0048180 ! activin complex + +[Term] +id: GO:0048184 +name: follistatin binding +namespace: molecular_function +def: "Interacting selectively with the peptide hormone follistatin." [GOC:jic, GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0048185 +name: activin binding +namespace: molecular_function +def: "Interacting selectively with activin, a dimer of inhibin-beta subunits." [GOC:jic, GOC:mah] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0048186 +name: inhibin beta-A binding +namespace: molecular_function +def: "Interacting selectively with inhibin beta-A." [GOC:jic] +is_a: GO:0034711 ! inhibin binding + +[Term] +id: GO:0048187 +name: inhibin beta-B binding +namespace: molecular_function +def: "Interacting selectively with inhibin beta-B." [GOC:jic] +is_a: GO:0034711 ! inhibin binding + +[Term] +id: GO:0048188 +name: COMPASS complex +namespace: cellular_component +def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p." [PMID:11687631, PMID:11805083] +synonym: "Set1 complex" NARROW [] +synonym: "Set1C" NARROW [] +is_a: GO:0016585 ! chromatin remodeling complex +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0048189 +name: Lid2 complex +namespace: cellular_component +def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447] +is_a: GO:0016585 ! chromatin remodeling complex + +[Term] +id: GO:0048190 +name: wing disc dorsal/ventral pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jic] +is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc +is_a: GO:0035222 ! wing disc pattern formation + +[Term] +id: GO:0048191 +name: peptide stabilization activity +namespace: molecular_function +def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jic] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0050822 + +[Term] +id: GO:0048192 +name: peptide antigen stabilization activity +namespace: molecular_function +def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jic] +comment: This term was made obsolete because it represents a biological process. +is_obsolete: true +replaced_by: GO:0050823 + +[Term] +id: GO:0048193 +name: Golgi vesicle transport +namespace: biological_process +def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "Golgi-derived vesicle transport" EXACT [] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0048194 +name: Golgi vesicle budding +namespace: biological_process +def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle budding" NARROW [] +synonym: "Golgi-derived vesicle budding" EXACT [] +is_a: GO:0006900 ! membrane budding +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048195 +name: Golgi membrane priming complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "formation of dictyosome membrane priming complex" NARROW [] +synonym: "formation of Golgi membrane priming complex" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0048200 ! Golgi transport vesicle coating + +[Term] +id: GO:0048196 +name: middle lamella-containing extracellular matrix +namespace: cellular_component +def: "The matrix external to the cell, composed of the cell wall and middle lamella." [GOC:jic, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk] +comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell. +subset: goslim_pir +synonym: "extracellular matrix (sensu Magnoliophyta)" EXACT [] +is_a: GO:0030312 ! external encapsulating structure +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0048197 +name: Golgi membrane coat protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW [] +synonym: "dictyosome membrane bud coat oligomerisation" NARROW [] +synonym: "Golgi membrane bud coat oligomerisation" NARROW [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0048200 ! Golgi transport vesicle coating + +[Term] +id: GO:0048198 +name: Golgi vesicle bud deformation and release +namespace: biological_process +def: "The process by which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle bud deformation" NARROW [] +synonym: "Golgi-derived vesicle bud deformation and release" EXACT [] +is_a: GO:0016044 ! membrane organization +relationship: part_of GO:0048194 ! Golgi vesicle budding + +[Term] +id: GO:0048199 +name: vesicle targeting, to, from or within Golgi +namespace: biological_process +def: "The process by which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle targeting" NARROW [] +synonym: "Golgi vesicle targeting" EXACT [] +synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] +is_a: GO:0006903 ! vesicle targeting +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048200 +name: Golgi transport vesicle coating +namespace: biological_process +def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome transport vesicle coating" NARROW [] +is_a: GO:0006901 ! vesicle coating +relationship: part_of GO:0048194 ! Golgi vesicle budding +relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi + +[Term] +id: GO:0048201 +name: vesicle targeting, plasma membrane to endosome +namespace: biological_process +def: "The process by which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "plasma membrane to endosome targeting" EXACT [] +is_a: GO:0006903 ! vesicle targeting + +[Term] +id: GO:0048202 +name: clathrin coating of Golgi vesicle +namespace: biological_process +def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "clathrin coating of Golgi-derived vesicle" EXACT [] +is_a: GO:0048200 ! Golgi transport vesicle coating +is_a: GO:0048268 ! clathrin coat assembly + +[Term] +id: GO:0048203 +name: vesicle targeting, trans-Golgi to endosome +namespace: biological_process +def: "The process by which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "trans-Golgi to endosome targeting" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0006895 ! Golgi to endosome transport + +[Term] +id: GO:0048204 +name: vesicle targeting, inter-Golgi cisterna +namespace: biological_process +def: "The process by which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "inter-Golgi cisterna targeting" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport + +[Term] +id: GO:0048205 +name: COPI coating of Golgi vesicle +namespace: biological_process +def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "COPI coating of Golgi-derived vesicle" EXACT [] +is_a: GO:0048200 ! Golgi transport vesicle coating + +[Term] +id: GO:0048206 +name: vesicle targeting, cis-Golgi to rough ER +namespace: biological_process +def: "The process by which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT [] +synonym: "cis-Golgi to rough ER targeting" EXACT [] +synonym: "vesicle targeting, cis-Golgi to rough endoplasmic reticulum" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +is_a: GO:0048220 ! cis-Golgi to rough ER vesicle-mediated transport + +[Term] +id: GO:0048207 +name: vesicle targeting, rough ER to cis-Golgi +namespace: biological_process +def: "The process by which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT [] +synonym: "rough ER to cis-Golgi targeting" EXACT [] +synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0048221 ! rough ER to cis-Golgi vesicle-mediated transport + +[Term] +id: GO:0048208 +name: COPII coating of Golgi vesicle +namespace: biological_process +def: "The addition of COPII proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "COPII coating of Golgi-derived vesicle" EXACT [] +is_a: GO:0048200 ! Golgi transport vesicle coating +relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi + +[Term] +id: GO:0048209 +name: regulation of vesicle targeting, to, from or within Golgi +namespace: biological_process +def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "regulation of Golgi vesicle targeting" EXACT [] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi + +[Term] +id: GO:0048210 +name: Golgi vesicle fusion to target membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle fusion to target membrane" NARROW [] +synonym: "Golgi-derived vesicle fusion to target membrane" EXACT [] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048211 +name: Golgi vesicle docking +namespace: biological_process +def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle docking to target membrane" NARROW [] +synonym: "Golgi vesicle docking with target membrane" EXACT [] +synonym: "Golgi vesicle to membrane docking" EXACT [] +synonym: "Golgi-derived vesicle docking" EXACT [] +is_a: GO:0048278 ! vesicle docking +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048212 +name: Golgi vesicle uncoating +namespace: biological_process +def: "The process by which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle coat depolymerization" NARROW [] +synonym: "Golgi vesicle coat depolymerization" EXACT [] +synonym: "Golgi vesicle coat protein depolymerization" EXACT [] +synonym: "Golgi-derived vesicle uncoating" EXACT [] +is_a: GO:0051261 ! protein depolymerization +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048213 +name: Golgi vesicle prefusion complex stabilization +namespace: biological_process +def: "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW [] +synonym: "Golgi vesicle prefusion complex assembly" EXACT [] +synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048214 +name: regulation of Golgi vesicle fusion to target membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233] +comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion. +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane + +[Term] +id: GO:0048215 +name: positive regulation of Golgi vesicle fusion to target membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "activation of Golgi vesicle fusion to target membrane" NARROW [] +synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW [] +synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT [] +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane +relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane + +[Term] +id: GO:0048216 +name: negative regulation of Golgi vesicle fusion to target membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW [] +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane +relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane + +[Term] +id: GO:0048217 +name: pectic matrix +namespace: cellular_component +def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009530 ! primary cell wall +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048219 +name: inter-Golgi cisterna vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "inter-Golgi cisterna transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048220 +name: cis-Golgi to rough ER vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from the Golgi apparatus to the rough endoplasmic reticulum, mediated by vesicles." [GOC:jic, ISBN:0716731363, PMID:10219233] +synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT [] +synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [] +synonym: "cis-Golgi to rough ER transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048221 +name: rough ER to cis-Golgi vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from the rough endoplasmic reticulum to the cis-Golgi, mediated by small transport vesicles." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT [] +synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [] +synonym: "rough ER to cis-Golgi transport" EXACT [] +xref: Reactome:159763 +xref: Reactome:211901 +xref: Reactome:221665 +xref: Reactome:230256 +xref: Reactome:238292 +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048222 +name: glycoprotein network +namespace: cellular_component +def: "A network of glycoproteins; proteins with covalently attached sugar units, either bonded via the hydroxyl group of serine or threonine (O glycosylated) or through the amino terminal of asparagine (N glycosylated)." [GOC:jic, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +synonym: "extensin" EXACT [] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009530 ! primary cell wall + +[Term] +id: GO:0048223 +name: hemicellulose network +namespace: cellular_component +def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009530 ! primary cell wall +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048224 +name: lignin network +namespace: cellular_component +def: "A network composed of lignin; a complex polymer of phenylpropanoid subunits, laid down in the walls of plant cells such as xylem vessels and sclerenchyma. It imparts considerable strength to the wall and also protects it against degradation by microorganisms. It is also laid down as a defence reaction against pathogenic attack, as part of the hypersensitive response of plants." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048225 +name: suberin network +namespace: cellular_component +def: "Fatty substance, containing long chain fatty acids and fatty esters, found in the cell walls of cork cells (phellem) in higher plants. Renders the cell wall impervious to water." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048226 +name: Casparian strip +namespace: cellular_component +def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0044420 ! extracellular matrix part +is_a: GO:0044426 ! cell wall part +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048227 +name: plasma membrane to endosome transport +namespace: biological_process +def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jic] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0048228 +name: actin cortical patch distribution +namespace: biological_process +def: "OBSOLETE. Any process that establish the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jic] +comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms. +is_obsolete: true + +[Term] +id: GO:0048229 +name: gametophyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "gametogenesis (sensu Magnoliophyta)" EXACT [] +synonym: "gametophyte development (sensu Magnoliophyta)" EXACT [] +is_a: GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0048232 +name: male gamete generation +namespace: biological_process +def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0007276 ! gamete generation + +[Term] +id: GO:0048235 +name: pollen sperm cell differentiation +namespace: biological_process +alt_id: GO:0048234 +def: "The process whereby a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [GOC:jic, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk] +synonym: "male gamete generation (sensu Magnoliophyta)" EXACT [] +synonym: "male gametophyte sperm cell differentiation" EXACT [] +synonym: "sperm cell differentiation (sensu Magnoliophyta)" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048232 ! male gamete generation + +[Term] +id: GO:0048236 +name: plant-type spore development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spore over time, from its formation to the mature structure. The spore gives rise to gametophytes." [GOC:jic, http://www.m-w.com] +synonym: "plant spore development" EXACT [] +synonym: "spore development (sensu Magnoliophyta)" EXACT [] +is_a: GO:0048869 ! cellular developmental process +is_a: GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0048237 +name: rough endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jic] +synonym: "rough ER lumen" EXACT [] +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0005791 ! rough endoplasmic reticulum + +[Term] +id: GO:0048238 +name: smooth endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jic] +synonym: "smooth ER lumen" EXACT [] +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0005790 ! smooth endoplasmic reticulum + +[Term] +id: GO:0048239 +name: negative regulation of DNA recombination at telomere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jic, PMID:9635193] +synonym: "down regulation of telomeric recombination at telomere" EXACT [] +synonym: "down-regulation of telomeric recombination at telomere" EXACT [] +synonym: "downregulation of telomeric recombination at telomere" EXACT [] +synonym: "inhibition of telomeric recombination at telomere" NARROW [] +synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb] +synonym: "suppression of telomeric recombination at telomere" EXACT [] +is_a: GO:0000722 ! telomere maintenance via recombination +is_a: GO:0045910 ! negative regulation of DNA recombination + +[Term] +id: GO:0048240 +name: sperm capacitation +namespace: biological_process +def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jic, PMID:11820818] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0048241 +name: epinephrine transport +namespace: biological_process +def: "The directed movement of epinephrine into, out of, within or between cells." [GOC:jic] +synonym: "adrenaline transport" EXACT [] +is_a: GO:0009914 ! hormone transport +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0048242 +name: epinephrine secretion +namespace: biological_process +def: "The regulated release of epinephrine by a cell or group of cells. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jic] +synonym: "adrenaline secretion" EXACT [] +is_a: GO:0048241 ! epinephrine transport +is_a: GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0048243 +name: norepinephrine secretion +namespace: biological_process +def: "The regulated release of norepinephrine by a cell or group of cells. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jic] +synonym: "noradrenaline secretion" EXACT [] +is_a: GO:0015874 ! norepinephrine transport +is_a: GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0048244 +name: phytanoyl-CoA dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2." [EC:1.14.11.18, GOC:jic] +synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.18] +synonym: "phytanoyl-CoA 2-hydroxylase activity" EXACT [EC:1.14.11.18] +synonym: "phytanoyl-CoA alpha-hydroxylase activity" EXACT [EC:1.14.11.18] +synonym: "phytanoyl-CoA hydroxylase activity" EXACT [EC:1.14.11.18] +synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.11.18] +xref: EC:1.14.11.18 +xref: MetaCyc:1.14.11.18-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0048245 +name: eosinophil chemotaxis +namespace: biological_process +def: "The movement of an eosinophil in response to an external stimulus." [GOC:jic, PMID:11292027, PMID:12391252] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0048246 +name: macrophage chemotaxis +namespace: biological_process +def: "The movement of a macrophage in response to an external stimulus." [GOC:jic] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0048247 +name: lymphocyte chemotaxis +namespace: biological_process +def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jic, PMID:12391252] +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0048248 +name: CXCR3 chemokine receptor binding +namespace: molecular_function +def: "Interacting selectively with a the CXCR3 chemokine receptor." [GOC:jic, PMID:10556837] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0048249 +name: high affinity phosphate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jic, PMID:8709965] +is_a: GO:0015114 ! phosphate transmembrane transporter activity + +[Term] +id: GO:0048250 +name: mitochondrial iron ion transport +namespace: biological_process +def: "The directed movement of iron ions into, out of or within a mitochondrion." [GOC:jic, PMID:12006577] +synonym: "mitochondrial iron transport" EXACT [] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0006839 ! mitochondrial transport + +[Term] +id: GO:0048251 +name: elastic fiber assembly +namespace: biological_process +def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jic, PMID:10841810, PMID:12615674] +synonym: "elastic fibre assembly" EXACT [] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0048252 +name: lauric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [GOC:jic, http://cancerweb.ncl.ac.uk] +subset: gosubset_prok +synonym: "lauric acid metabolism" EXACT [] +synonym: "n-dodecanoic acid metabolic process" EXACT [] +synonym: "n-dodecanoic acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0048254 +name: snoRNA localization +namespace: biological_process +def: "Any process by which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363] +synonym: "establishment and maintenance of snoRNA localization" EXACT [] +synonym: "small nucleolar RNA localization" EXACT [] +is_a: GO:0006403 ! RNA localization +is_a: GO:0016074 ! snoRNA metabolic process + +[Term] +id: GO:0048255 +name: mRNA stabilization +namespace: biological_process +def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jic] +subset: gosubset_prok +is_a: GO:0043488 ! regulation of mRNA stability +is_a: GO:0043489 ! RNA stabilization + +[Term] +id: GO:0048256 +name: flap endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jic] +subset: gosubset_prok +xref: EC:3.1.-.-. +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0048257 +name: 3'-flap endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jic, PMID:10635319] +synonym: "3' flap endonuclease activity" EXACT [] +is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters +is_a: GO:0048256 ! flap endonuclease activity + +[Term] +id: GO:0048258 +name: 3-ketoglucose-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN] +xref: EC:1.1.1.- +xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0048259 +name: regulation of receptor-mediated endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] +synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb] +is_a: GO:0030100 ! regulation of endocytosis +relationship: regulates GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0048260 +name: positive regulation of receptor-mediated endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] +synonym: "activation of receptor mediated endocytosis" NARROW [] +synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb] +synonym: "stimulation of receptor mediated endocytosis" NARROW [] +synonym: "up regulation of receptor mediated endocytosis" EXACT [] +synonym: "up-regulation of receptor mediated endocytosis" EXACT [] +synonym: "upregulation of receptor mediated endocytosis" EXACT [] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0048261 +name: negative regulation of receptor-mediated endocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators] +synonym: "down regulation of receptor mediated endocytosis" EXACT [] +synonym: "down-regulation of receptor mediated endocytosis" EXACT [] +synonym: "downregulation of receptor mediated endocytosis" EXACT [] +synonym: "inhibition of receptor mediated endocytosis" NARROW [] +synonym: "negative regulation of receptor mediated endocytosis" EXACT [] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0048262 +name: determination of dorsoventral asymmetry +namespace: biological_process +def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb] +synonym: "determination of dorsal/ventral asymmetry" EXACT [] +is_a: GO:0009855 ! determination of bilateral symmetry +relationship: part_of GO:0009953 ! dorsal/ventral pattern formation + +[Term] +id: GO:0048263 +name: determination of dorsal identity +namespace: biological_process +def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jic] +synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0048262 ! determination of dorsoventral asymmetry + +[Term] +id: GO:0048264 +name: determination of ventral identity +namespace: biological_process +def: "The regionalization process by which the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jic] +synonym: "determination of abaxial identity" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0048262 ! determination of dorsoventral asymmetry + +[Term] +id: GO:0048265 +name: response to pain +namespace: biological_process +alt_id: GO:0048267 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jic, http://www.wikipedia.org, PMID:10203867, PMID:12723742, PMID:12843304] +synonym: "physiological response to pain" EXACT [] +is_a: GO:0033555 ! multicellular organismal response to stress + +[Term] +id: GO:0048266 +name: behavioral response to pain +namespace: biological_process +def: "A change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jic, http://cancerweb.ncl.ac.uk] +synonym: "behavioural response to pain" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0048265 ! response to pain + +[Term] +id: GO:0048268 +name: clathrin coat assembly +namespace: biological_process +def: "The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage." [GOC:jic, PMID:11460887, PMID:11977118, PMID:9531549] +synonym: "clathrin cage assembly" EXACT [] +is_a: GO:0006461 ! protein complex assembly +is_a: GO:0006901 ! vesicle coating + +[Term] +id: GO:0048269 +name: methionine adenosyltransferase complex +namespace: cellular_component +def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jic, PMID:10644686] +synonym: "MAT complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0048270 +name: methionine adenosyltransferase regulator activity +namespace: molecular_function +def: "Modulates the activity of methionine adenosyltransferase." [EC:2.5.1.6, GOC:jic, PMID:10644686] +comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'. +synonym: "MAT regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0048273 +name: mitogen-activated protein kinase p38 binding +namespace: molecular_function +def: "Interacting selectively with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [http://cancerweb.ncl.ac.uk] +synonym: "MAPK p38 binding" EXACT [] +is_a: GO:0051019 ! mitogen-activated protein kinase binding + +[Term] +id: GO:0048275 +name: N-terminal peptidyl-arginine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354] +subset: gosubset_prok +xref: RESID:AA0354 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0048277 +name: nonexocytotic vesicle docking +namespace: biological_process +def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jic] +comment: This term was made obsolete because it violates the principle of positivity. +synonym: "non-exocytotic vesicle docking" EXACT [] +is_obsolete: true +replaced_by: GO:0048278 + +[Term] +id: GO:0048278 +name: vesicle docking +namespace: biological_process +def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jic] +subset: gosubset_prok +synonym: "vesicle to membrane docking" EXACT [] +is_a: GO:0022406 ! membrane docking +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0048279 +name: vesicle fusion with endoplasmic reticulum +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jic] +synonym: "vesicle fusion with ER" EXACT [] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:0048280 +name: vesicle fusion with Golgi apparatus +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jic] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:0048281 +name: inflorescence morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of inflorescences are generated and organized. Morphogenesis pertains to the creation of form. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0010229 ! inflorescence development + +[Term] +id: GO:0048282 +name: determinate inflorescence morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of determinate inflorescences are generated and organized. Morphogenesis pertains to the creation of form. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jic, PMID:9553044] +is_a: GO:0048281 ! inflorescence morphogenesis + +[Term] +id: GO:0048283 +name: indeterminate inflorescence morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of determinate inflorescences are generated and organized. Morphogenesis pertains to the creation of form. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jic] +is_a: GO:0048281 ! inflorescence morphogenesis + +[Term] +id: GO:0048284 +name: organelle fusion +namespace: biological_process +def: "The creation of a single organelle from two or more organelles." [GOC:jic] +subset: goslim_pir +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0048285 +name: organelle fission +namespace: biological_process +def: "The creation of two or more organelles by division of one organelle." [GOC:jic] +subset: goslim_pir +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0048286 +name: alveolus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [PMID:9751757] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0048288 +name: nuclear membrane fusion during karyogamy +namespace: biological_process +def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jic] +is_a: GO:0000740 ! nuclear membrane fusion +relationship: part_of GO:0000741 ! karyogamy + +[Term] +id: GO:0048289 +name: isotype switching to IgE isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] +synonym: "class switch recombination to IgE isotypes" EXACT [] +synonym: "class switching to IgE isotypes" EXACT [] +synonym: "isotype switch recombination to IgE isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048290 +name: isotype switching to IgA isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] +synonym: "class switching to IgA isotypes" EXACT [] +synonym: "isotype switch recombination to IgA isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048291 +name: isotype switching to IgG isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] +synonym: "class switching to IgG isotypes" EXACT [] +synonym: "isotype switch recombination to IgG isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048292 +name: isotype switching to IgD isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655] +comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms. +synonym: "class switching to IgD isotypes" EXACT [] +synonym: "isotype switch recombination to IgD isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048293 +name: regulation of isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jic] +synonym: "regulation of class switch recombination to IgE isotypes" EXACT [] +synonym: "regulation of class switching to IgE isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0048294 +name: negative regulation of isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jic] +synonym: "down regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgE isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgE isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT [] +synonym: "negative regulation of class switching to IgE isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes +relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0048295 +name: positive regulation of isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jic] +synonym: "activation of isotype switching to IgE isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT [] +synonym: "positive regulation of class switching to IgE isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgE isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgE isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes +relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0048296 +name: regulation of isotype switching to IgA isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jic] +synonym: "regulation of class switch recombination to IgA isotypes" EXACT [] +synonym: "regulation of class switching to IgA isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048290 ! isotype switching to IgA isotypes + +[Term] +id: GO:0048297 +name: negative regulation of isotype switching to IgA isotypes +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jic] +synonym: "down regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgA isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgA isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT [] +synonym: "negative regulation of class switching to IgA isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes +relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes + +[Term] +id: GO:0048298 +name: positive regulation of isotype switching to IgA isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jic] +synonym: "activation of isotype switching to IgA isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT [] +synonym: "positive regulation of class switching to IgA isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgA isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgA isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes +relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes + +[Term] +id: GO:0048299 +name: regulation of isotype switching to IgD isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jic] +synonym: "regulation of class switch recombination to IgD isotypes" EXACT [] +synonym: "regulation of class switching to IgD isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048292 ! isotype switching to IgD isotypes + +[Term] +id: GO:0048300 +name: negative regulation of isotype switching to IgD isotypes +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jic] +synonym: "down regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgD isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgD isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT [] +synonym: "negative regulation of class switching to IgD isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes +relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes + +[Term] +id: GO:0048301 +name: positive regulation of isotype switching to IgD isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jic] +synonym: "activation of isotype switching to IgD isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT [] +synonym: "positive regulation of class switching to IgD isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgD isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgD isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes +relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes + +[Term] +id: GO:0048302 +name: regulation of isotype switching to IgG isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jic] +synonym: "regulation of class switch recombination to IgG isotypes" EXACT [] +synonym: "regulation of class switching to IgG isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048291 ! isotype switching to IgG isotypes + +[Term] +id: GO:0048303 +name: negative regulation of isotype switching to IgG isotypes +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jic] +synonym: "down regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgG isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgG isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT [] +synonym: "negative regulation of class switching to IgG isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes +relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes + +[Term] +id: GO:0048304 +name: positive regulation of isotype switching to IgG isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jic] +synonym: "activation of isotype switching to IgG isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT [] +synonym: "positive regulation of class switching to IgG isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgG isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgG isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes +relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes + +[Term] +id: GO:0048305 +name: immunoglobulin secretion +namespace: biological_process +def: "The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563] +synonym: "antibody secretion" EXACT [] +is_a: GO:0009306 ! protein secretion +relationship: part_of GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0048306 +name: calcium-dependent protein binding +namespace: molecular_function +def: "Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [GOC:jic, PMID:10485905] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0048307 +name: ferredoxin-nitrite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = NO2(-) (nitrite) + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jic] +subset: gosubset_prok +synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1] +xref: EC:1.7.7.1 +is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0048308 +name: organelle inheritance +namespace: biological_process +def: "The partitioning of organelles between daughter cells at cell division." [GOC:jic] +subset: goslim_pir +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0048309 +name: endoplasmic reticulum inheritance +namespace: biological_process +def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jic] +synonym: "ER inheritance" EXACT [] +is_a: GO:0007029 ! endoplasmic reticulum organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0048310 +name: nucleus inheritance +namespace: biological_process +def: "The partitioning of nuclei between daughter cells at cell division." [GOC:jic] +synonym: "cell nucleus inheritance" EXACT [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0048311 +name: mitochondrion distribution +namespace: biological_process +def: "Any process that establish the spatial arrangement of mitochondria between and within cells." [GOC:jic] +synonym: "distribution of mitochondria" EXACT [] +synonym: "mitochondrial distribution" EXACT [] +synonym: "positioning of mitochondria" RELATED [] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0051646 ! mitochondrion localization + +[Term] +id: GO:0048312 +name: intracellular distribution of mitochondria +namespace: biological_process +def: "Any process that establish the spatial arrangement of mitochondria within the cell." [GOC:jic] +synonym: "mitochondria positioning within cell" EXACT [] +synonym: "mitochondrion positioning within cell" EXACT [] +is_a: GO:0048311 ! mitochondrion distribution + +[Term] +id: GO:0048313 +name: Golgi inheritance +namespace: biological_process +def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jic, PMID:12851069] +synonym: "Golgi partitioning" EXACT [] +is_a: GO:0007030 ! Golgi organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0048314 +name: embryo sac morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the embryo sac are generated and organized. Morphogenesis pertains to the creation of form. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jic, GOC:mtg_plant, http://www.bio.uu.nl] +synonym: "female gametophyte morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0048315 +name: conidium formation +namespace: biological_process +def: "Formation of asexual, nonmotile spores in fungi, by conversion of hyphal elements or arising from specialized sporogenous cells." [ISBN:0963117211, PMID:2524423, PMID:9529886] +synonym: "conidia biosynthesis" EXACT [] +synonym: "conidia formation" EXACT [] +is_a: GO:0030436 ! asexual sporulation +is_a: GO:0048646 ! anatomical structure formation + +[Term] +id: GO:0048316 +name: seed development +namespace: biological_process +def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0048317 +name: seed morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the seed are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0048318 +name: axial mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0048319 +name: axial mesoderm morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the axial mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048332 ! mesoderm morphogenesis +relationship: part_of GO:0048318 ! axial mesoderm development + +[Term] +id: GO:0048320 +name: axial mesoderm formation +namespace: biological_process +def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048319 ! axial mesoderm morphogenesis + +[Term] +id: GO:0048321 +name: axial mesodermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh] +synonym: "axial mesoderm cell differentiation" EXACT [] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048320 ! axial mesoderm formation + +[Term] +id: GO:0048322 +name: axial mesodermal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh] +synonym: "axial mesoderm cell fate commitment" EXACT [] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048321 ! axial mesodermal cell differentiation + +[Term] +id: GO:0048323 +name: axial mesodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] +synonym: "axial mesoderm cell fate determination" EXACT [] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment + +[Term] +id: GO:0048324 +name: regulation of axial mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048323 ! axial mesodermal cell fate determination + +[Term] +id: GO:0048325 +name: negative regulation of axial mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "downregulation of axial mesodermal cell fate determination" EXACT [] +synonym: "inhibition of axial mesodermal cell fate determination" NARROW [] +is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination + +[Term] +id: GO:0048326 +name: positive regulation of axial mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of axial mesodermal cell fate determination" NARROW [] +synonym: "stimulation of axial mesodermal cell fate determination" NARROW [] +synonym: "up regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "upregulation of axial mesodermal cell fate determination" EXACT [] +is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination + +[Term] +id: GO:0048327 +name: axial mesodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] +synonym: "axial mesoderm cell fate specification" EXACT [] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment + +[Term] +id: GO:0048328 +name: regulation of axial mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0048329 +name: negative regulation of axial mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] +synonym: "down regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "downregulation of axial mesodermal cell fate specification" EXACT [] +synonym: "inhibition of axial mesodermal cell fate specification" NARROW [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification +relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0048330 +name: positive regulation of axial mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of axial mesodermal cell fate specification" NARROW [] +synonym: "stimulation of axial mesodermal cell fate specification" NARROW [] +synonym: "up regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "upregulation of axial mesodermal cell fate specification" EXACT [] +is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0048331 +name: axial mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "axial mesoderm structural organisation" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048319 ! axial mesoderm morphogenesis + +[Term] +id: GO:0048332 +name: mesoderm morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0048333 +name: mesodermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] +synonym: "mesoderm cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001707 ! mesoderm formation + +[Term] +id: GO:0048334 +name: regulation of mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0010470 ! regulation of gastrulation +relationship: regulates GO:0007500 ! mesodermal cell fate determination + +[Term] +id: GO:0048335 +name: negative regulation of mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of mesodermal cell fate determination" EXACT [] +synonym: "downregulation of mesodermal cell fate determination" EXACT [] +synonym: "inhibition of mesodermal cell fate determination" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination + +[Term] +id: GO:0048336 +name: positive regulation of mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of mesodermal cell fate determination" NARROW [] +synonym: "stimulation of mesodermal cell fate determination" NARROW [] +synonym: "up regulation of mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of mesodermal cell fate determination" EXACT [] +synonym: "upregulation of mesodermal cell fate determination" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination + +[Term] +id: GO:0048337 +name: positive regulation of mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of mesodermal cell fate specification" NARROW [] +synonym: "stimulation of mesodermal cell fate specification" NARROW [] +synonym: "up regulation of mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of mesodermal cell fate specification" EXACT [] +synonym: "upregulation of mesodermal cell fate specification" EXACT [] +is_a: GO:0042660 ! positive regulation of cell fate specification +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0048338 +name: mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "mesoderm structural organisation" EXACT [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048332 ! mesoderm morphogenesis + +[Term] +id: GO:0048339 +name: paraxial mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0048340 +name: paraxial mesoderm morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the paraxial mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048332 ! mesoderm morphogenesis +relationship: part_of GO:0048339 ! paraxial mesoderm development + +[Term] +id: GO:0048341 +name: paraxial mesoderm formation +namespace: biological_process +def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis + +[Term] +id: GO:0048342 +name: paraxial mesodermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048341 ! paraxial mesoderm formation + +[Term] +id: GO:0048343 +name: paraxial mesodermal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation + +[Term] +id: GO:0048344 +name: paraxial mesodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment + +[Term] +id: GO:0048345 +name: regulation of paraxial mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination + +[Term] +id: GO:0048346 +name: positive regulation of paraxial mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of paraxial mesodermal cell fate determination" NARROW [] +synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW [] +synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT [] +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination +relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination + +[Term] +id: GO:0048347 +name: negative regulation of paraxial mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW [] +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination +relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination + +[Term] +id: GO:0048348 +name: paraxial mesodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment + +[Term] +id: GO:0048349 +name: regulation of paraxial mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification + +[Term] +id: GO:0048350 +name: positive regulation of paraxial mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of paraxial mesodermal cell fate specification" NARROW [] +synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW [] +synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT [] +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification +relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification + +[Term] +id: GO:0048351 +name: negative regulation of paraxial mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] +synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification +relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification + +[Term] +id: GO:0048352 +name: paraxial mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "paraxial mesoderm structural organisation" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis + +[Term] +id: GO:0048353 +name: primary endosperm nucleus +namespace: cellular_component +def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0048354 +name: mucilage biosynthetic process during seed coat development +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur during seed coat development; mucilage is normally synthesized during seed coat development." [GOC:jic] +synonym: "mucilage anabolism during seed coat development" EXACT [] +synonym: "mucilage formation during seed coat development" EXACT [] +synonym: "mucilage synthesis during seed coat development" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048359 ! mucilage metabolic process during seed coat development + +[Term] +id: GO:0048355 +name: root cap mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jic] +synonym: "root cap mucilage anabolism" EXACT [] +synonym: "root cap mucilage biosynthesis" EXACT [] +synonym: "root cap mucilage formation" EXACT [] +synonym: "root cap mucilage synthesis" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048360 ! root cap mucilage metabolic process + +[Term] +id: GO:0048356 +name: root epithelial mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jic] +synonym: "root epithelial mucilage anabolism" EXACT [] +synonym: "root epithelial mucilage biosynthesis" EXACT [] +synonym: "root epithelial mucilage formation" EXACT [] +synonym: "root epithelial mucilage synthesis" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process + +[Term] +id: GO:0048357 +name: pedicel mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jic] +synonym: "pedicel mucilage anabolism" EXACT [] +synonym: "pedicel mucilage biosynthesis" EXACT [] +synonym: "pedicel mucilage formation" EXACT [] +synonym: "pedicel mucilage synthesis" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048362 ! pedicel mucilage metabolic process + +[Term] +id: GO:0048358 +name: mucilage pectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jic] +synonym: "mucilage pectin anabolism" EXACT [] +synonym: "mucilage pectin biosynthesis" EXACT [] +synonym: "mucilage pectin formation" EXACT [] +synonym: "mucilage pectin synthesis" EXACT [] +is_a: GO:0045489 ! pectin biosynthetic process +is_a: GO:0048363 ! mucilage pectin metabolic process +relationship: part_of GO:0010192 ! mucilage biosynthetic process + +[Term] +id: GO:0048359 +name: mucilage metabolic process during seed coat development +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur during seed coat development; mucilage is normally synthesized during seed coat development." [GOC:jic] +synonym: "mucilage metabolism during seed coat development" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0048360 +name: root cap mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jic] +synonym: "root cap mucilage metabolism" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048361 +name: root epithelial mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jic] +synonym: "root epithelial mucilage metabolism" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048362 +name: pedicel mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jic] +synonym: "pedicel mucilage metabolism" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048363 +name: mucilage pectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jic] +synonym: "mucilage pectin metabolism" EXACT [] +is_a: GO:0045488 ! pectin metabolic process +relationship: part_of GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048364 +name: root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0022622 ! root system development + +[Term] +id: GO:0048365 +name: Rac GTPase binding +namespace: molecular_function +def: "Interacting selectively with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases." [GOC:ebc, PMID:11702775] +is_a: GO:0017048 ! Rho GTPase binding + +[Term] +id: GO:0048366 +name: leaf development +namespace: biological_process +def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048827 ! phyllome development + +[Term] +id: GO:0048367 +name: shoot development +namespace: biological_process +def: "The process whose specific outcome is the progression of the shoot over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0022621 ! shoot system development + +[Term] +id: GO:0048368 +name: lateral mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] +synonym: "lateral plate mesoderm development" EXACT [] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0048369 +name: lateral mesoderm morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the lateral mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +synonym: "lateral plate mesoderm morphogenesis" EXACT [] +is_a: GO:0048332 ! mesoderm morphogenesis +relationship: part_of GO:0048368 ! lateral mesoderm development + +[Term] +id: GO:0048370 +name: lateral mesoderm formation +namespace: biological_process +def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jic] +synonym: "lateral plate mesoderm biosynthesis" EXACT [] +synonym: "lateral plate mesoderm formation" EXACT [] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis + +[Term] +id: GO:0048371 +name: lateral mesodermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jic] +synonym: "lateral mesoderm cell differentiation" EXACT [] +synonym: "lateral plate mesoderm cell differentiation" EXACT [] +synonym: "lateral plate mesodermal cell differentiation" EXACT [] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048370 ! lateral mesoderm formation + +[Term] +id: GO:0048372 +name: lateral mesodermal cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become a lateral mesoderm cell." [GOC:jic] +synonym: "lateral mesoderm cell fate commitment" EXACT [] +synonym: "lateral plate mesoderm cell fate commitment" EXACT [] +synonym: "lateral plate mesodermal cell fate commitment" EXACT [] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation + +[Term] +id: GO:0048373 +name: lateral mesodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jic] +synonym: "lateral mesoderm cell fate determination" EXACT [] +synonym: "lateral plate mesoderm cell fate determination" EXACT [] +synonym: "lateral plate mesodermal cell fate determination" EXACT [] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment + +[Term] +id: GO:0048374 +name: regulation of lateral mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jic] +synonym: "regulation of lateral mesoderm cell fate determination" EXACT [] +synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT [] +synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT [] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination + +[Term] +id: GO:0048375 +name: negative regulation of lateral mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jic] +synonym: "down regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "downregulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "inhibition of lateral mesodermal cell fate determination" NARROW [] +synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT [] +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination +relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination + +[Term] +id: GO:0048376 +name: positive regulation of lateral mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jic] +synonym: "activation of lateral mesodermal cell fate determination" NARROW [] +synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT [] +synonym: "stimulation of lateral mesodermal cell fate determination" NARROW [] +synonym: "up regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "upregulation of lateral mesodermal cell fate determination" EXACT [] +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination +relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination + +[Term] +id: GO:0048377 +name: lateral mesodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jic] +synonym: "lateral mesoderm cell fate specification" EXACT [] +synonym: "lateral plate mesoderm cell fate specification" EXACT [] +synonym: "lateral plate mesodermal cell fate specification" EXACT [] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment + +[Term] +id: GO:0048378 +name: regulation of lateral mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jic] +synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT [] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification + +[Term] +id: GO:0048379 +name: positive regulation of lateral mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jic] +synonym: "activation of lateral mesodermal cell fate specification" NARROW [] +synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT [] +synonym: "stimulation of lateral mesodermal cell fate specification" NARROW [] +synonym: "up regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "upregulation of lateral mesodermal cell fate specification" EXACT [] +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification +relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification + +[Term] +id: GO:0048380 +name: negative regulation of lateral mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jic] +synonym: "down regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "downregulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "inhibition of lateral mesodermal cell fate specification" NARROW [] +synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification +relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification + +[Term] +id: GO:0048381 +name: lateral mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "lateral mesoderm structural organisation" EXACT [] +synonym: "lateral plate mesoderm structural organization" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis + +[Term] +id: GO:0048382 +name: mesendoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jic] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007492 ! endoderm development +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0048383 +name: mesectoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jic] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007398 ! ectoderm development +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0048384 +name: retinoic acid receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh] +synonym: "RAR signaling pathway" EXACT [] +synonym: "retinoic acid receptor signalling pathway" EXACT [] +is_a: GO:0030522 ! intracellular receptor-mediated signaling pathway + +[Term] +id: GO:0048385 +name: regulation of retinoic acid receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] +synonym: "regulation of RAR signaling pathway" EXACT [] +synonym: "regulation of retinoic acid receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway + +[Term] +id: GO:0048386 +name: positive regulation of retinoic acid receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] +synonym: "activation of retinoic acid receptor signaling pathway" NARROW [] +synonym: "positive regulation of RAR signaling pathway" EXACT [] +synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT [] +synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW [] +synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway +relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway + +[Term] +id: GO:0048387 +name: negative regulation of retinoic acid receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] +synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW [] +synonym: "negative regulation of RAR signaling pathway" EXACT [] +synonym: "negative regulation of RAR signalling pathway" EXACT [] +synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway +relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway + +[Term] +id: GO:0048388 +name: endosomal lumen acidification +namespace: biological_process +def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jic] +is_a: GO:0051452 ! intracellular pH reduction +relationship: part_of GO:0007032 ! endosome organization + +[Term] +id: GO:0048389 +name: intermediate mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0048390 +name: intermediate mesoderm morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the intermediate mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048332 ! mesoderm morphogenesis +relationship: part_of GO:0048389 ! intermediate mesoderm development + +[Term] +id: GO:0048391 +name: intermediate mesoderm formation +namespace: biological_process +def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis + +[Term] +id: GO:0048392 +name: intermediate mesodermal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh] +synonym: "intermediate mesoderm cell differentiation" EXACT [] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048391 ! intermediate mesoderm formation + +[Term] +id: GO:0048393 +name: intermediate mesodermal cell fate commitment +namespace: biological_process +def: "The process by which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh] +synonym: "intermediate mesoderm cell fate commitment" EXACT [] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation + +[Term] +id: GO:0048394 +name: intermediate mesodermal cell fate determination +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] +synonym: "intermediate mesoderm cell fate determination" EXACT [] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment + +[Term] +id: GO:0048395 +name: regulation of intermediate mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination + +[Term] +id: GO:0048396 +name: negative regulation of intermediate mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW [] +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination +relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination + +[Term] +id: GO:0048397 +name: positive regulation of intermediate mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of intermediate mesodermal cell fate determination" NARROW [] +synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW [] +synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT [] +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination +relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination + +[Term] +id: GO:0048398 +name: intermediate mesodermal cell fate specification +namespace: biological_process +def: "Process by which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] +synonym: "intermediate mesoderm cell fate specification" EXACT [] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment + +[Term] +id: GO:0048399 +name: regulation of intermediate mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification + +[Term] +id: GO:0048400 +name: positive regulation of intermediate mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of intermediate mesodermal cell fate specification" NARROW [] +synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW [] +synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT [] +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification +relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification + +[Term] +id: GO:0048401 +name: negative regulation of intermediate mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] +synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification +relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification + +[Term] +id: GO:0048402 +name: intermediate mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "intermediate mesoderm structural organisation" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis + +[Term] +id: GO:0048403 +name: brain-derived neurotrophic factor binding +namespace: molecular_function +def: "Interacting selectively with brain-derived neurotrophic factor." [GOC:dgh] +synonym: "BDNF binding" EXACT [] +synonym: "neurotrophin TRKB receptor activity" RELATED [] +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0048404 +name: neurotrophin-3 binding +namespace: molecular_function +def: "Interacting selectively with neurotrophin-3." [GOC:dgh] +synonym: "neurotrophin 3 binding" EXACT [] +synonym: "neurotrophin TRKA receptor activity" RELATED [] +synonym: "neurotrophin TRKB receptor activity" RELATED [] +synonym: "neurotrophin TRKC receptor activity" RELATED [] +synonym: "NT-3 binding" EXACT [] +synonym: "NT3 binding" EXACT [] +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0048405 +name: neurotrophin-4/5 binding +namespace: molecular_function +def: "Interacting selectively with neurotrophin-4/5." [GOC:dgh] +comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. +synonym: "neurotrophin 4/5 binding" EXACT [] +synonym: "neurotrophin TRKB receptor activity" RELATED [] +synonym: "NT 4/5 binding" EXACT [] +synonym: "NT-4 binding" NARROW [] +synonym: "NT-4/5 binding" EXACT [] +synonym: "NT-5 binding" NARROW [] +synonym: "NT4 binding" NARROW [] +synonym: "NT5 binding" NARROW [] +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0048406 +name: nerve growth factor binding +namespace: molecular_function +def: "Interacting selectively with nerve growth factor." [GOC:dgh] +synonym: "neurotrophin TRKA receptor activity" RELATED [] +synonym: "NGF binding" EXACT [] +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0048407 +name: platelet-derived growth factor binding +namespace: molecular_function +def: "Interacting selectively with platelet-derived growth factor." [GOC:dgh] +synonym: "PDGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0048408 +name: epidermal growth factor binding +namespace: molecular_function +def: "Interacting selectively with epidermal growth factor." [GOC:dgh] +synonym: "EGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0048437 +name: floral organ development +namespace: biological_process +alt_id: GO:0048433 +def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048569 ! post-embryonic organ development +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048438 +name: floral whorl development +namespace: biological_process +alt_id: GO:0048413 +def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048439 +name: flower morphogenesis +namespace: biological_process +alt_id: GO:0048411 +def: "The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048440 +name: carpel development +namespace: biological_process +alt_id: GO:0048429 +def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators, http://cancerweb.ncl.ac.uk] +is_a: GO:0048437 ! floral organ development +relationship: part_of GO:0048467 ! gynoecium development + +[Term] +id: GO:0048441 +name: petal development +namespace: biological_process +alt_id: GO:0048417 +def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +relationship: part_of GO:0048465 ! corolla development + +[Term] +id: GO:0048442 +name: sepal development +namespace: biological_process +alt_id: GO:0048421 +def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +relationship: part_of GO:0048464 ! calyx development + +[Term] +id: GO:0048443 +name: stamen development +namespace: biological_process +alt_id: GO:0048425 +def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +relationship: part_of GO:0048466 ! androecium development + +[Term] +id: GO:0048444 +name: floral organ morphogenesis +namespace: biological_process +alt_id: GO:0048434 +def: "The process by which the anatomical structures of the floral organ are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0048445 +name: carpel morphogenesis +namespace: biological_process +alt_id: GO:0048430 +def: "The process by which the anatomical structures of the carpel are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048446 +name: petal morphogenesis +namespace: biological_process +alt_id: GO:0048418 +def: "The process by which the anatomical structures of the petal are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048441 ! petal development + +[Term] +id: GO:0048447 +name: sepal morphogenesis +namespace: biological_process +alt_id: GO:0048422 +def: "The process by which the anatomical structures of the sepal are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048442 ! sepal development + +[Term] +id: GO:0048448 +name: stamen morphogenesis +namespace: biological_process +alt_id: GO:0048426 +def: "The process by which the anatomical structures of the stamen are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048443 ! stamen development + +[Term] +id: GO:0048449 +name: floral organ formation +namespace: biological_process +alt_id: GO:0048436 +def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048444 ! floral organ morphogenesis +is_a: GO:0048645 ! organ formation + +[Term] +id: GO:0048450 +name: floral organ structural organization +namespace: biological_process +alt_id: GO:0048435 +def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "floral organ structural organisation" EXACT [] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048461 ! flower structural organization + +[Term] +id: GO:0048451 +name: petal formation +namespace: biological_process +alt_id: GO:0048419 +def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048446 ! petal morphogenesis + +[Term] +id: GO:0048452 +name: petal structural organization +namespace: biological_process +alt_id: GO:0048420 +def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "petal structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048446 ! petal morphogenesis + +[Term] +id: GO:0048453 +name: sepal formation +namespace: biological_process +alt_id: GO:0048423 +def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048447 ! sepal morphogenesis + +[Term] +id: GO:0048454 +name: sepal structural organization +namespace: biological_process +alt_id: GO:0048424 +def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "sepal structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048447 ! sepal morphogenesis + +[Term] +id: GO:0048455 +name: stamen formation +namespace: biological_process +alt_id: GO:0048427 +def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048448 ! stamen morphogenesis + +[Term] +id: GO:0048456 +name: stamen structural organization +namespace: biological_process +alt_id: GO:0048428 +def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "stamen structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048448 ! stamen morphogenesis + +[Term] +id: GO:0048457 +name: floral whorl morphogenesis +namespace: biological_process +alt_id: GO:0048414 +def: "The process by which the anatomical structures of the floral whorl are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048438 ! floral whorl development +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048458 +name: floral whorl formation +namespace: biological_process +alt_id: GO:0048415 +def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048457 ! floral whorl morphogenesis + +[Term] +id: GO:0048459 +name: floral whorl structural organization +namespace: biological_process +alt_id: GO:0048416 +def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "floral whorl structural organisation" EXACT [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048457 ! floral whorl morphogenesis +relationship: part_of GO:0048461 ! flower structural organization + +[Term] +id: GO:0048460 +name: flower formation +namespace: biological_process +alt_id: GO:0048410 +def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048461 +name: flower structural organization +namespace: biological_process +alt_id: GO:0048412 +def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "flower structural organisation" EXACT [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048462 +name: carpel formation +namespace: biological_process +alt_id: GO:0048431 +def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048445 ! carpel morphogenesis + +[Term] +id: GO:0048463 +name: carpel structural organization +namespace: biological_process +alt_id: GO:0048432 +def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic] +synonym: "carpel structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048445 ! carpel morphogenesis + +[Term] +id: GO:0048464 +name: calyx development +namespace: biological_process +def: "The process whose specific outcome is the progression of the calyx over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048465 +name: corolla development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048466 +name: androecium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048467 +name: gynoecium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, http://cancerweb.ncl.ac.uk] +synonym: "pistil development" EXACT [] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048468 +name: cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] +subset: goslim_candida +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0030154 ! cell differentiation + +[Term] +id: GO:0048469 +name: cell maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0048471 +name: perinuclear region of cytoplasm +namespace: cellular_component +def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jic] +comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'. +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0048472 +name: threonine-phosphate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2." [EC:4.1.1.81, GOC:mlg] +subset: gosubset_prok +synonym: "CobD" RELATED [EC:4.1.1.81] +synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81] +synonym: "L-threonine O-3-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.81] +synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT [] +xref: EC:4.1.1.81 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0048473 +name: D-methionine transport +namespace: biological_process +def: "The directed movement of D-methionine into, out of, within, or between cells." [GOC:mlg, PMID:12169620] +subset: gosubset_prok +is_a: GO:0000101 ! sulfur amino acid transport + +[Term] +id: GO:0048474 +name: D-methionine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of D-methionine from one side of a membrane to the other." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "D-methionine transporter activity" BROAD [] +is_a: GO:0043865 ! methionine transmembrane transporter activity + +[Term] +id: GO:0048475 +name: coated membrane +namespace: cellular_component +def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jic] +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0048476 +name: Holliday junction resolvase complex +namespace: cellular_component +def: "A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage." [PMID:11207366, PMID:12374758] +subset: goslim_pir +synonym: "Mus81-Eme1 complex" NARROW [] +synonym: "resolvasome" EXACT [PMID:11207366] +is_a: GO:0043234 ! protein complex +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0048477 +name: oogenesis +namespace: biological_process +alt_id: GO:0009993 +alt_id: GO:0048157 +def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:kmv, GOC:mtg_sensu] +synonym: "oogenesis (sensu Insecta)" RELATED [] +synonym: "oogenesis (sensu Mammalia)" RELATED [] +synonym: "ovum development" EXACT systematic_synonym [] +is_a: GO:0007292 ! female gamete generation + +[Term] +id: GO:0048478 +name: replication fork protection +namespace: biological_process +def: "Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029] +synonym: "replication fork maintenance" BROAD [] +synonym: "replication fork stabilization" BROAD [] +is_a: GO:0008156 ! negative regulation of DNA replication + +[Term] +id: GO:0048479 +name: style development +namespace: biological_process +def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048480 +name: stigma development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jic, http://cancerweb.ncl.ac.uk] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048481 +name: ovule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048482 +name: ovule morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the ovule are generated and organized. Morphogenesis pertains to the creation of form. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048445 ! carpel morphogenesis +relationship: part_of GO:0048481 ! ovule development + +[Term] +id: GO:0048483 +name: autonomic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0048484 +name: enteric nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk] +is_a: GO:0048731 ! system development +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0048485 +name: sympathetic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk] +is_a: GO:0048731 ! system development +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0048486 +name: parasympathetic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk] +is_a: GO:0048731 ! system development +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0048487 +name: beta-tubulin binding +namespace: molecular_function +def: "Interacting selectively with the microtubule constituent protein beta-tubulin." [GOC:krc] +synonym: "beta tubulin binding" EXACT [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0048488 +name: synaptic vesicle endocytosis +namespace: biological_process +alt_id: GO:0008099 +def: "Invagination of the axonal plasma membrane creating a membrane-bounded vesicle. Without this process the presynaptic terminal would swell up due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage/release." [GOC:jic, GOC:lmg] +subset: gosubset_prok +synonym: "synaptic vesicle retrieval" RELATED [] +is_a: GO:0006897 ! endocytosis +is_a: GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:0048489 +name: synaptic vesicle transport +namespace: biological_process +alt_id: GO:0016181 +def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jic, GOC:lmg] +subset: gosubset_prok +synonym: "synaptic vesicle fission" RELATED [] +synonym: "synaptic vesicle fusion" RELATED [] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0048490 +name: anterograde synaptic vesicle transport +namespace: biological_process +def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body." [GOC:jic, GOC:lmg] +is_a: GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:0048491 +name: retrograde synaptic vesicle transport +namespace: biological_process +def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, toward the neuronal cell body." [GOC:jic, GOC:lmg] +is_a: GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:0048492 +name: ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg] +subset: goslim_pir +subset: gosubset_prok +synonym: "RubisCO complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0048493 +name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT [] +synonym: "ribulose bisphosphate carboxylase complex (sensu Cyanobacteria)" EXACT [] +synonym: "RubisCO complex (sensu Cyanobacteria)" EXACT [] +is_a: GO:0044436 ! thylakoid part +is_a: GO:0044459 ! plasma membrane part +is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex +relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid + +[Term] +id: GO:0048494 +name: chromatophore ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "ribulose bisphosphate carboxylase complex (sensu Proteobacteria, Chloroflexaceae and Chlorobiaceae)" EXACT [] +synonym: "RubisCO complex (sensu Proteobacteria)" EXACT [] +is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex +relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0048495 +name: Roundabout binding +namespace: molecular_function +def: "Interacting selectively with the Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527] +synonym: "Roundabout receptor binding" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0048496 +name: maintenance of organ identity +namespace: biological_process +def: "The process by which the identity of an organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883] +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: part_of GO:0048513 ! organ development + +[Term] +id: GO:0048497 +name: maintenance of floral organ identity +namespace: biological_process +def: "The process by which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883] +is_a: GO:0048496 ! maintenance of organ identity +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0048498 +name: establishment of petal orientation +namespace: biological_process +def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040] +is_a: GO:0048559 ! establishment of floral organ orientation +relationship: part_of GO:0048446 ! petal morphogenesis + +[Term] +id: GO:0048499 +name: synaptic vesicle membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806] +synonym: "SLMV biogenesis" NARROW [] +synonym: "synaptic vesicle membrane organisation and biogenesis" EXACT [] +synonym: "synaptic vesicle membrane organization and biogenesis" EXACT [] +is_a: GO:0016044 ! membrane organization + +[Term] +id: GO:0048500 +name: signal recognition particle +namespace: cellular_component +def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0030529 ! ribonucleoprotein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0048501 +name: signal recognition particle, plasma membrane targeting +namespace: cellular_component +def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu] +subset: gosubset_prok +synonym: "signal recognition particle (sensu Bacteria and Archaea)" EXACT [] +is_a: GO:0048500 ! signal recognition particle + +[Term] +id: GO:0048502 +name: thiamin-transporting ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + thiamin(out) = ADP + phosphate + thiamin(in)." [GOC:mlg, PMID:9535878] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +synonym: "thiamin ABC transporter" NARROW [] +synonym: "thiamine-transporting ATPase activity" EXACT [] +is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances + +[Term] +id: GO:0048503 +name: GPI anchor binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] +comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors. +synonym: "glycosylphosphatidylinositol binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048504 +name: regulation of timing of organ formation +namespace: biological_process +def: "The process controlling the point in time during development when an organ will form, and/or the rate at which organ formation occurs." [GOC:bf, GOC:jic] +synonym: "timing of organ biosynthesis" RELATED [] +synonym: "timing of organ formation" RELATED [] +is_a: GO:0040034 ! regulation of development, heterochronic +relationship: part_of GO:0048645 ! organ formation + +[Term] +id: GO:0048505 +name: regulation of timing of cell differentiation +namespace: biological_process +def: "The process controlling the timing and/or rate at which relatively unspecialized cells acquire specialized features." [GOC:bf, GOC:jic] +synonym: "timing of cell differentiation" RELATED [] +is_a: GO:0040034 ! regulation of development, heterochronic +is_a: GO:0045595 ! regulation of cell differentiation + +[Term] +id: GO:0048506 +name: regulation of timing of meristematic phase transition +namespace: biological_process +def: "The process controlling the point in time during development when a meristem will change its identity, and/or the rate at which the change occurs." [GOC:jic] +is_a: GO:0040034 ! regulation of development, heterochronic +is_a: GO:0048509 ! regulation of meristem development + +[Term] +id: GO:0048507 +name: meristem development +namespace: biological_process +def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0048508 +name: embryonic meristem development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0048507 ! meristem development +relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy + +[Term] +id: GO:0048509 +name: regulation of meristem development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048507 ! meristem development + +[Term] +id: GO:0048510 +name: regulation of timing of transition from vegetative to reproductive phase +namespace: biological_process +def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jic, PMID:8974397] +is_a: GO:0048506 ! regulation of timing of meristematic phase transition + +[Term] +id: GO:0048511 +name: rhythmic process +namespace: biological_process +def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jic] +subset: goslim_pir +subset: gosubset_prok +synonym: "rhythm" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0048512 +name: circadian behavior +namespace: biological_process +def: "The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] +synonym: "circadian rhythm behavior" EXACT [] +is_a: GO:0007622 ! rhythmic behavior +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0048513 +name: organ development +namespace: biological_process +def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jic] +synonym: "development of an organ" EXACT [] +synonym: "organogenesis" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048731 ! system development + +[Term] +id: GO:0048514 +name: blood vessel morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood." [GOC:jic] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0001568 ! blood vessel development + +[Term] +id: GO:0048515 +name: spermatid differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a spermatid cell." [GOC:jic] +synonym: "spermatid cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048516 +name: trichome initiation (sensu Magnoliophyta) +namespace: biological_process +def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] +comment: This term was made obsolete because more appropriate terms were created. +is_obsolete: true +consider: GO:0048629 + +[Term] +id: GO:0048517 +name: positive regulation of trichome initiation (sensu Magnoliophyta) +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] +comment: This term was made obsolete because more appropriate terms were created. +is_obsolete: true +consider: GO:0048629 + +[Term] +id: GO:0048518 +name: positive regulation of biological process +namespace: biological_process +alt_id: GO:0043119 +def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jic] +subset: gosubset_prok +synonym: "activation of biological process" NARROW [] +synonym: "positive regulation of physiological process" EXACT [] +synonym: "stimulation of biological process" NARROW [] +synonym: "up regulation of biological process" EXACT [] +synonym: "up-regulation of biological process" EXACT [] +synonym: "upregulation of biological process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: positively_regulates GO:0008150 ! biological_process + +[Term] +id: GO:0048519 +name: negative regulation of biological process +namespace: biological_process +alt_id: GO:0043118 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jic] +subset: gosubset_prok +synonym: "down regulation of biological process" EXACT [] +synonym: "down-regulation of biological process" EXACT [] +synonym: "downregulation of biological process" EXACT [] +synonym: "inhibition of biological process" NARROW [] +synonym: "negative regulation of physiological process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: negatively_regulates GO:0008150 ! biological_process + +[Term] +id: GO:0048520 +name: positive regulation of behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:jic] +synonym: "activation of behavior" NARROW [] +synonym: "stimulation of behavior" NARROW [] +synonym: "up regulation of behavior" EXACT [] +synonym: "up-regulation of behavior" EXACT [] +synonym: "upregulation of behavior" EXACT [] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0050795 ! regulation of behavior +relationship: positively_regulates GO:0007610 ! behavior + +[Term] +id: GO:0048521 +name: negative regulation of behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:jic] +synonym: "down regulation of behavior" EXACT [] +synonym: "down-regulation of behavior" EXACT [] +synonym: "downregulation of behavior" EXACT [] +synonym: "inhibition of behavior" NARROW [] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0050795 ! regulation of behavior +relationship: negatively_regulates GO:0007610 ! behavior + +[Term] +id: GO:0048522 +name: positive regulation of cellular process +namespace: biological_process +alt_id: GO:0051242 +def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jic] +subset: gosubset_prok +synonym: "activation of cellular process" NARROW [] +synonym: "positive regulation of cellular physiological process" EXACT [] +synonym: "stimulation of cellular process" NARROW [] +synonym: "up regulation of cellular process" EXACT [] +synonym: "up-regulation of cellular process" EXACT [] +synonym: "upregulation of cellular process" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0050794 ! regulation of cellular process +relationship: positively_regulates GO:0009987 ! cellular process + +[Term] +id: GO:0048523 +name: negative regulation of cellular process +namespace: biological_process +alt_id: GO:0051243 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jic] +subset: gosubset_prok +synonym: "down regulation of cellular process" EXACT [] +synonym: "down-regulation of cellular process" EXACT [] +synonym: "downregulation of cellular process" EXACT [] +synonym: "inhibition of cellular process" NARROW [] +synonym: "negative regulation of cellular physiological process" EXACT [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050794 ! regulation of cellular process +relationship: negatively_regulates GO:0009987 ! cellular process + +[Term] +id: GO:0048524 +name: positive regulation of viral reproduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:jic, GOC:tb] +synonym: "activation of viral life cycle" NARROW [] +synonym: "positive regulation of viral life cycle" EXACT [GOC:tb] +synonym: "stimulation of viral life cycle" NARROW [] +synonym: "up regulation of viral life cycle" EXACT [] +synonym: "up-regulation of viral life cycle" EXACT [] +synonym: "upregulation of viral life cycle" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0050792 ! regulation of viral reproduction +relationship: positively_regulates GO:0016032 ! viral reproduction + +[Term] +id: GO:0048525 +name: negative regulation of viral reproduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:jic, GOC:tb] +synonym: "down regulation of viral life cycle" EXACT [] +synonym: "down-regulation of viral life cycle" EXACT [] +synonym: "downregulation of viral life cycle" EXACT [] +synonym: "inhibition of viral life cycle" NARROW [] +synonym: "negative regulation of viral life cycle" EXACT [GOC:tb] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050792 ! regulation of viral reproduction +relationship: negatively_regulates GO:0016032 ! viral reproduction + +[Term] +id: GO:0048526 +name: imaginal disc-derived wing expansion +namespace: biological_process +def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] +synonym: "wing expansion" EXACT [] +synonym: "wing inflation" EXACT [] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0048527 +name: lateral root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb] +is_a: GO:0048364 ! root development +is_a: GO:0048528 ! post-embryonic root development + +[Term] +id: GO:0048528 +name: post-embryonic root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048529 +name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81] +synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.81] +synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" EXACT [EC:1.14.13.81] +synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" EXACT [EC:1.14.13.81] +xref: EC:1.14.13.81 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0048530 +name: fruit morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a fruit are generated and organized. Morphogenesis pertains to the creation of form. A fruit is a reproductive body of a seed plant." [GOC:sm] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:0048531 +name: beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958] +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0048532 +name: anatomical structure arrangement +namespace: biological_process +def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators] +synonym: "anatomical structure organization" BROAD [] +synonym: "anatomical structure structural organization" EXACT [] +synonym: "organization of an anatomical structure" EXACT [] +synonym: "structural organization" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0048533 +name: sporocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators] +synonym: "sporocyte development" NARROW [] +synonym: "sporocyte morphogenesis" RELATED [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048534 +name: hemopoietic or lymphoid organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "haematopoietic or lymphoid organ development" EXACT [] +synonym: "haemopoietic or lymphoid organ development" EXACT [] +synonym: "hematopoietic or lymphoid organ development" EXACT [] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0002520 ! immune system development + +[Term] +id: GO:0048535 +name: lymph node development +namespace: biological_process +def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] +synonym: "lymph gland development (sensu Vertebrata)" EXACT [] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development + +[Term] +id: GO:0048536 +name: spleen development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development + +[Term] +id: GO:0048537 +name: mucosal-associated lymphoid tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of mucosal- associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "BALT development" NARROW [] +synonym: "bronchial-associated lymphoid tissue development" NARROW [] +synonym: "GALT development" NARROW [] +synonym: "gut-associated lymphoid tissue development" NARROW [] +synonym: "NALT development" NARROW [] +synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW [] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development + +[Term] +id: GO:0048538 +name: thymus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere. +is_a: GO:0048534 ! hemopoietic or lymphoid organ development + +[Term] +id: GO:0048539 +name: bone marrow development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0048540 +name: bursa development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bursa over time, from its formation to the mature structure. The bursa is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development + +[Term] +id: GO:0048541 +name: Peyer's patch development +namespace: biological_process +def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] +synonym: "GALT development" RELATED [] +synonym: "gut-associated lymphoid tissue development" RELATED [] +is_a: GO:0048537 ! mucosal-associated lymphoid tissue development + +[Term] +id: GO:0048542 +name: lymph gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] +synonym: "haematopoietic organ development (sensu Arthropoda)" EXACT [] +synonym: "haemopoietic organ development (sensu Arthropoda)" EXACT [] +synonym: "hematopoietic organ development (sensu Arthropoda)" EXACT [] +synonym: "hemopoietic organ development (sensu Arthropoda)" EXACT [] +synonym: "lymph gland development (sensu Arthropoda)" EXACT [] +is_a: GO:0048534 ! hemopoietic or lymphoid organ development +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0048543 +name: phytochrome chromophore biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515] +synonym: "phytochrome chromophore anabolism" EXACT [] +synonym: "phytochrome chromophore biosynthesis" EXACT [] +synonym: "phytochrome chromophore formation" EXACT [] +synonym: "phytochrome chromophore synthesis" EXACT [] +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0048544 +name: recognition of pollen +namespace: biological_process +alt_id: GO:0009857 +def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb] +synonym: "pollen recognition" EXACT [] +synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb] +synonym: "self incompatibility" RELATED [] +is_a: GO:0008037 ! cell recognition +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0048545 +name: response to steroid hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] +is_a: GO:0009725 ! response to hormone stimulus + +[Term] +id: GO:0048546 +name: digestive tract morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines." [GOC:go_curators, PMID:12618131] +synonym: "alimentary canal morphogenesis" EXACT [] +synonym: "digestive tube morphogenesis" EXACT [] +synonym: "gastrointestinal tract morphogenesis" EXACT [] +is_a: GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0048547 +name: gut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators, PMID:12618131] +synonym: "intestinal morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048546 ! digestive tract morphogenesis +relationship: part_of GO:0048565 ! gut development + +[Term] +id: GO:0048548 +name: regulation of pinocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] +is_a: GO:0030100 ! regulation of endocytosis +relationship: regulates GO:0006907 ! pinocytosis + +[Term] +id: GO:0048549 +name: positive regulation of pinocytosis +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] +synonym: "activation of pinocytosis" NARROW [] +synonym: "stimulation of pinocytosis" NARROW [] +synonym: "up regulation of pinocytosis" EXACT [] +synonym: "up-regulation of pinocytosis" EXACT [] +synonym: "upregulation of pinocytosis" EXACT [] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0048548 ! regulation of pinocytosis +relationship: positively_regulates GO:0006907 ! pinocytosis + +[Term] +id: GO:0048550 +name: negative regulation of pinocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] +synonym: "down regulation of pinocytosis" EXACT [] +synonym: "down-regulation of pinocytosis" EXACT [] +synonym: "downregulation of pinocytosis" EXACT [] +synonym: "inhibition of pinocytosis" NARROW [] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0048548 ! regulation of pinocytosis +relationship: negatively_regulates GO:0006907 ! pinocytosis + +[Term] +id: GO:0048551 +name: metalloenzyme inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0010576 ! metalloenzyme regulator activity + +[Term] +id: GO:0048552 +name: regulation of metalloenzyme activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] +subset: gosubset_prok +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0048553 +name: negative regulation of metalloenzyme activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] +synonym: "down regulation of metalloenzyme activity" EXACT [] +synonym: "down-regulation of metalloenzyme activity" EXACT [] +synonym: "downregulation of metalloenzyme activity" EXACT [] +synonym: "inhibition of metalloenzyme activity" NARROW [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0048552 ! regulation of metalloenzyme activity + +[Term] +id: GO:0048554 +name: positive regulation of metalloenzyme activity +namespace: biological_process +def: "Any process that activates, maintains or increases the rate activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc] +synonym: "activation of metalloenzyme activity" NARROW [] +synonym: "stimulation of metalloenzyme activity" NARROW [] +synonym: "up regulation of metalloenzyme activity" EXACT [] +synonym: "up-regulation of metalloenzyme activity" EXACT [] +synonym: "upregulation of metalloenzyme activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0048552 ! regulation of metalloenzyme activity + +[Term] +id: GO:0048555 +name: generative cell nucleus +namespace: cellular_component +def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators] +synonym: "male germ cell nucleus (sensu Magnoliophyta)" EXACT [] +synonym: "sperm cell nucleus (sensu Magnoliophyta)" RELATED [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0048556 +name: microsporocyte nucleus +namespace: cellular_component +alt_id: GO:0043074 +def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X] +synonym: "microspore mother cell nucleus" EXACT [] +synonym: "pollen mother cell nucleus" EXACT [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0048557 +name: embryonic digestive tract morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines." [GOC:go_curators] +is_a: GO:0048546 ! digestive tract morphogenesis +is_a: GO:0048562 ! embryonic organ morphogenesis + +[Term] +id: GO:0048558 +name: embryonic gut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the gut are generated and organized during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048547 ! gut morphogenesis +relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis +relationship: part_of GO:0048566 ! embryonic gut development + +[Term] +id: GO:0048559 +name: establishment of floral organ orientation +namespace: biological_process +def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jic] +is_a: GO:0048561 ! establishment of organ orientation +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048560 +name: establishment of anatomical structure orientation +namespace: biological_process +def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jic] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0048561 +name: establishment of organ orientation +namespace: biological_process +def: "The process that determines the orientation of an organ or tissue with reference to an axis." [GOC:jic] +is_a: GO:0048560 ! establishment of anatomical structure orientation +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0048562 +name: embryonic organ morphogenesis +namespace: biological_process +def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic] +is_a: GO:0009887 ! organ morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048568 ! embryonic organ development + +[Term] +id: GO:0048563 +name: post-embryonic organ morphogenesis +namespace: biological_process +def: "Morphogenesis, during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic] +is_a: GO:0009886 ! post-embryonic morphogenesis +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0048569 ! post-embryonic organ development + +[Term] +id: GO:0048564 +name: photosystem I assembly +namespace: biological_process +alt_id: GO:0010251 +def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0048565 +name: gut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators] +synonym: "intestinal development" EXACT [] +synonym: "intestine development" EXACT [] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0048566 +name: embryonic gut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators] +is_a: GO:0048565 ! gut development +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0048567 +name: ectodermal gut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form. The ectodermal gut includes those portions of the gut that are derived from ectoderm." [GOC:jic] +is_a: GO:0007439 ! ectodermal gut development +is_a: GO:0048547 ! gut morphogenesis + +[Term] +id: GO:0048568 +name: embryonic organ development +namespace: biological_process +def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic] +synonym: "embryonic organogenesis" EXACT [] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0048569 +name: post-embryonic organ development +namespace: biological_process +def: "Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic] +synonym: "post-embryonic organogenesis" EXACT [] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0048570 +name: notochord morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the notochord are generated and organized. Morphogenesis pertains to the creation of form. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jic] +is_a: GO:0048562 ! embryonic organ morphogenesis +relationship: part_of GO:0030903 ! notochord development + +[Term] +id: GO:0048571 +name: long-day photoperiodism +namespace: biological_process +def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "response to long-day" EXACT [] +synonym: "response to long-day photoperiod" RELATED [] +synonym: "response to short-night" EXACT [] +synonym: "short-night photoperiodism" EXACT [] +is_a: GO:0009648 ! photoperiodism + +[Term] +id: GO:0048572 +name: short-day photoperiodism +namespace: biological_process +def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "long-night photoperiodism" EXACT [] +synonym: "response to long-night" EXACT [] +synonym: "response to short-day" EXACT [] +synonym: "response to short-day photoperiod" RELATED [] +is_a: GO:0009648 ! photoperiodism + +[Term] +id: GO:0048573 +name: photoperiodism, flowering +namespace: biological_process +def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "photoperiodic control of flowering time" EXACT [] +synonym: "photoperiodic control of inflorescence development" EXACT [] +synonym: "response to day length, flowering" EXACT [] +synonym: "response to night length, flowering" EXACT [] +synonym: "response to photoperiod, flowering" EXACT [] +is_a: GO:0009648 ! photoperiodism +relationship: part_of GO:0010228 ! vegetative to reproductive phase transition + +[Term] +id: GO:0048574 +name: long-day photoperiodism, flowering +namespace: biological_process +def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "long-day photoperiodic control of flowering" EXACT [] +synonym: "long-day photoperiodic control of flowering time" EXACT [] +synonym: "long-day photoperiodic control of inflorescence development" EXACT [] +synonym: "response to long-day, flowering" EXACT [] +synonym: "response to short-night, flowering" EXACT [] +synonym: "short-night photoperiodism, flowering" EXACT [] +is_a: GO:0048571 ! long-day photoperiodism +is_a: GO:0048573 ! photoperiodism, flowering + +[Term] +id: GO:0048575 +name: short-day photoperiodism, flowering +namespace: biological_process +def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "long-night photoperiodism, flowering" EXACT [] +synonym: "response to long-night, flowering" EXACT [] +synonym: "response to short-day, flowering" EXACT [] +synonym: "short-day photoperiodic control of flowering" EXACT [] +synonym: "short-day photoperiodic control of flowering time" EXACT [] +synonym: "short-day photoperiodic control of inflorescence development" EXACT [] +is_a: GO:0048572 ! short-day photoperiodism +is_a: GO:0048573 ! photoperiodism, flowering + +[Term] +id: GO:0048576 +name: positive regulation of short-day photoperiodism, flowering +namespace: biological_process +def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "activation of short-day photoperiodism, flowering" NARROW [] +synonym: "stimulation of short-day photoperiodism, flowering" NARROW [] +synonym: "up regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "up-regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "upregulation of short-day photoperiodism, flowering" EXACT [] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering +relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering + +[Term] +id: GO:0048577 +name: negative regulation of short-day photoperiodism, flowering +namespace: biological_process +def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "down regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "down-regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "downregulation of short-day photoperiodism, flowering" EXACT [] +synonym: "inhibition of short-day photoperiodism, flowering" NARROW [] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering +relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering + +[Term] +id: GO:0048578 +name: positive regulation of long-day photoperiodism, flowering +namespace: biological_process +def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "activation of long-day photoperiodism, flowering" NARROW [] +synonym: "stimulation of long-day photoperiodism, flowering" NARROW [] +synonym: "up regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "up-regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "upregulation of long-day photoperiodism, flowering" EXACT [] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering +relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering + +[Term] +id: GO:0048579 +name: negative regulation of long-day photoperiodism, flowering +namespace: biological_process +def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +synonym: "down regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "down-regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "downregulation of long-day photoperiodism, flowering" EXACT [] +synonym: "inhibition of long-day photoperiodism, flowering" NARROW [] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering +relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering + +[Term] +id: GO:0048580 +name: regulation of post-embryonic development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jic] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048581 +name: negative regulation of post-embryonic development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jic] +synonym: "down regulation of post-embryonic development" EXACT [] +synonym: "down-regulation of post-embryonic development" EXACT [] +synonym: "downregulation of post-embryonic development" EXACT [] +synonym: "inhibition of post-embryonic development" NARROW [] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048582 +name: positive regulation of post-embryonic development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jic] +synonym: "activation of post-embryonic development" NARROW [] +synonym: "stimulation of post-embryonic development" NARROW [] +synonym: "up regulation of post-embryonic development" EXACT [] +synonym: "up-regulation of post-embryonic development" EXACT [] +synonym: "upregulation of post-embryonic development" EXACT [] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048583 +name: regulation of response to stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jic] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0050896 ! response to stimulus + +[Term] +id: GO:0048584 +name: positive regulation of response to stimulus +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jic] +synonym: "activation of response to stimulus" NARROW [] +synonym: "stimulation of response to stimulus" NARROW [] +synonym: "up regulation of response to stimulus" EXACT [] +synonym: "up-regulation of response to stimulus" EXACT [] +synonym: "upregulation of response to stimulus" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: positively_regulates GO:0050896 ! response to stimulus + +[Term] +id: GO:0048585 +name: negative regulation of response to stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jic] +synonym: "down regulation of response to stimulus" EXACT [] +synonym: "down-regulation of response to stimulus" EXACT [] +synonym: "downregulation of response to stimulus" EXACT [] +synonym: "inhibition of response to stimulus" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: negatively_regulates GO:0050896 ! response to stimulus + +[Term] +id: GO:0048586 +name: regulation of long-day photoperiodism, flowering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0048574 ! long-day photoperiodism, flowering + +[Term] +id: GO:0048587 +name: regulation of short-day photoperiodism, flowering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:070940886] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0048575 ! short-day photoperiodism, flowering + +[Term] +id: GO:0048588 +name: developmental cell growth +namespace: biological_process +def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] +synonym: "developmental growth of a unicellular organism" EXACT [] +is_a: GO:0016049 ! cell growth +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0048589 +name: developmental growth +namespace: biological_process +def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] +is_a: GO:0032502 ! developmental process +is_a: GO:0040007 ! growth + +[Term] +id: GO:0048590 +name: non-developmental growth +namespace: biological_process +def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass is does not have the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] +is_a: GO:0040007 ! growth + +[Term] +id: GO:0048591 +name: non-developmental cell growth +namespace: biological_process +def: "The growth of a cell prior to division, where the growth does not change the cell from one condition to another condition over time." [GOC:go_curators, GOC:isa_complete] +synonym: "non-developmental growth of a unicellular organism" EXACT [] +is_a: GO:0016049 ! cell growth +is_a: GO:0048590 ! non-developmental growth + +[Term] +id: GO:0048592 +name: eye morphogenesis +namespace: biological_process +alt_id: GO:0048748 +def: "The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:mtg_sensu] +synonym: "eye morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0001654 ! eye development + +[Term] +id: GO:0048593 +name: camera-type eye morphogenesis +namespace: biological_process +alt_id: GO:0048594 +alt_id: GO:0048595 +def: "The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jic, GOC:mtg_sensu] +synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] +synonym: "eye morphogenesis (sensu Actinopterygii)" EXACT [] +synonym: "eye morphogenesis (sensu Mammalia)" EXACT [] +synonym: "eye morphogenesis (sensu Vertebrata)" EXACT [] +is_a: GO:0048592 ! eye morphogenesis +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0048596 +name: embryonic camera-type eye morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the eye are generated and organized during embryonic development. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:mtg_sensu] +synonym: "embryonic eye morphogenesis (sensu Actinopterygii)" EXACT [] +is_a: GO:0048048 ! embryonic eye morphogenesis +relationship: part_of GO:0031076 ! embryonic camera-type eye development +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0048597 +name: post-embryonic camera-type eye morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the eye are generated and organized during post-embryonic development. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:mtg_transport, ISBN:0815340729] +synonym: "post-embryonic camera-style eye morphogenesis" EXACT [] +synonym: "post-embryonic eye morphogenesis (sensu Actinopterygii)" EXACT [] +is_a: GO:0048050 ! post-embryonic eye morphogenesis +relationship: part_of GO:0031077 ! post-embryonic camera-type eye development +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0048598 +name: embryonic morphogenesis +namespace: biological_process +alt_id: GO:0048828 +def: "The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jic, GOC:mtg_sensu] +synonym: "embryonic morphogenesis (sensu Magnoliophyta)" NARROW [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009790 ! embryonic development + +[Term] +id: GO:0048599 +name: oocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] +is_a: GO:0007281 ! germ cell development +relationship: part_of GO:0009994 ! oocyte differentiation + +[Term] +id: GO:0048600 +name: oocyte fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0009994 ! oocyte differentiation + +[Term] +id: GO:0048601 +name: oocyte morphogenesis +namespace: biological_process +def: "The process by which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] +synonym: "oocyte morphogenesis during differentiation" EXACT [] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0048599 ! oocyte development + +[Term] +id: GO:0048602 +name: fibroblast growth factor 1 binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor 1." [GOC:ebc] +synonym: "FGF 1 binding" EXACT [] +is_a: GO:0017134 ! fibroblast growth factor binding + +[Term] +id: GO:0048603 +name: fibroblast growth factor 2 binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor 2." [GOC:ebc] +synonym: "FGF 2 binding" EXACT [] +is_a: GO:0017134 ! fibroblast growth factor binding + +[Term] +id: GO:0048604 +name: fibroblast growth factor 3 binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor 3." [GOC:ebc] +synonym: "FGF 3 binding" EXACT [] +is_a: GO:0017134 ! fibroblast growth factor binding + +[Term] +id: GO:0048605 +name: fibroblast growth factor 4 binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor 4." [GOC:ebc] +synonym: "FGF 4 binding" EXACT [] +is_a: GO:0017134 ! fibroblast growth factor binding + +[Term] +id: GO:0048606 +name: fibroblast growth factor 5 binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor 5." [GOC:ebc] +synonym: "FGF 5 binding" EXACT [] +is_a: GO:0017134 ! fibroblast growth factor binding + +[Term] +id: GO:0048607 +name: fibroblast growth factor 6 binding +namespace: molecular_function +def: "Interacting selectively with fibroblast growth factor 6." [GOC:ebc] +synonym: "FGF 6 binding" EXACT [] +is_a: GO:0017134 ! fibroblast growth factor binding + +[Term] +id: GO:0048608 +name: reproductive structure development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jic] +is_a: GO:0003006 ! reproductive developmental process +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0048609 +name: reproductive process in a multicellular organism +namespace: biological_process +def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jic, GOC:tb] +synonym: "organismal reproductive process" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0032504 ! multicellular organism reproduction + +[Term] +id: GO:0048610 +name: reproductive cellular process +namespace: biological_process +def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jic] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +is_a: GO:0022414 ! reproductive process + +[Term] +id: GO:0048611 +name: embryonic ectodermal gut development +namespace: biological_process +def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jic, GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007439 ! ectodermal gut development + +[Term] +id: GO:0048612 +name: post-embryonic ectodermal gut development +namespace: biological_process +def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jic, GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007439 ! ectodermal gut development + +[Term] +id: GO:0048613 +name: embryonic ectodermal gut morphogenesis +namespace: biological_process +def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048558 ! embryonic gut morphogenesis +relationship: part_of GO:0048567 ! ectodermal gut morphogenesis +relationship: part_of GO:0048611 ! embryonic ectodermal gut development + +[Term] +id: GO:0048614 +name: post-embryonic ectodermal gut morphogenesis +namespace: biological_process +def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0048567 ! ectodermal gut morphogenesis +relationship: part_of GO:0048612 ! post-embryonic ectodermal gut development +relationship: part_of GO:0048621 ! post-embryonic gut morphogenesis + +[Term] +id: GO:0048615 +name: embryonic anterior midgut (ectodermal) morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis +relationship: part_of GO:0048613 ! embryonic ectodermal gut morphogenesis + +[Term] +id: GO:0048616 +name: post-embryonic anterior midgut (ectodermal) morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis +relationship: part_of GO:0048614 ! post-embryonic ectodermal gut morphogenesis + +[Term] +id: GO:0048617 +name: embryonic foregut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the foregut are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007440 ! foregut morphogenesis + +[Term] +id: GO:0048618 +name: post-embryonic foregut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0007440 ! foregut morphogenesis + +[Term] +id: GO:0048619 +name: embryonic hindgut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the hindgut are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007442 ! hindgut morphogenesis + +[Term] +id: GO:0048620 +name: post-embryonic hindgut morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0007442 ! hindgut morphogenesis + +[Term] +id: GO:0048621 +name: post-embryonic gut morphogenesis +namespace: biological_process +def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:jic, GOC:rc] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0048547 ! gut morphogenesis + +[Term] +id: GO:0048622 +name: reproductive sporulation +namespace: biological_process +def: "OBSOLETE. The formation of reproductive spores." [GOC:jic] +comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology. +is_obsolete: true + +[Term] +id: GO:0048623 +name: seed germination on parent plant +namespace: biological_process +def: "The process by which a seed germinates before being shed from the parent plant." [GOC:go_curators] +synonym: "non-vegetative vivipary (sensu Magnoliophyta)" EXACT [] +synonym: "pre-harvest sprouting" EXACT [] +synonym: "vivipary (sensu Magnoliophyta)" BROAD [] +is_a: GO:0009845 ! seed germination + +[Term] +id: GO:0048624 +name: plantlet formation on parent plant +namespace: biological_process +def: "The process whereby a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators] +synonym: "vegetative vivipary (sensu Magnoliophyta)" EXACT [] +synonym: "vivipary (sensu Magnoliophyta)" BROAD [] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0032504 ! multicellular organism reproduction +is_a: GO:0048507 ! meristem development + +[Term] +id: GO:0048625 +name: myoblast cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0048626 +name: myoblast cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048625 ! myoblast cell fate commitment + +[Term] +id: GO:0048627 +name: myoblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0048628 +name: myoblast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048627 ! myoblast development + +[Term] +id: GO:0048629 +name: trichome patterning +namespace: biological_process +def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jic, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181] +synonym: "trichome distribution (sensu Magnoliophyta)" EXACT [] +synonym: "trichome pattern biosynthesis" EXACT [] +synonym: "trichome pattern formation" EXACT [] +synonym: "trichome pattern specification (sensu Magnoliophyta)" EXACT [] +synonym: "trichome patterning (sensu Magnoliophyta)" EXACT [] +synonym: "trichome spacing" EXACT [] +is_a: GO:0003002 ! regionalization +is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment +relationship: part_of GO:0010026 ! trichome differentiation + +[Term] +id: GO:0048630 +name: skeletal muscle growth +namespace: biological_process +def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0048631 +name: regulation of skeletal muscle growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0048641 ! regulation of skeletal muscle development +relationship: regulates GO:0048630 ! skeletal muscle growth + +[Term] +id: GO:0048632 +name: negative regulation of skeletal muscle growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] +synonym: "down regulation of skeletal muscle growth" EXACT [] +synonym: "down-regulation of skeletal muscle growth" EXACT [] +synonym: "downregulation of skeletal muscle growth" EXACT [] +synonym: "inhibition of skeletal muscle growth" NARROW [] +is_a: GO:0048631 ! regulation of skeletal muscle growth +is_a: GO:0048640 ! negative regulation of developmental growth +relationship: negatively_regulates GO:0048630 ! skeletal muscle growth +relationship: part_of GO:0048642 ! negative regulation of skeletal muscle development + +[Term] +id: GO:0048633 +name: positive regulation of skeletal muscle growth +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] +synonym: "activation of skeletal muscle growth" NARROW [] +synonym: "stimulation of skeletal muscle growth" NARROW [] +synonym: "up regulation of skeletal muscle growth" EXACT [] +synonym: "up-regulation of skeletal muscle growth" EXACT [] +synonym: "upregulation of skeletal muscle growth" EXACT [] +is_a: GO:0048631 ! regulation of skeletal muscle growth +is_a: GO:0048639 ! positive regulation of developmental growth +relationship: part_of GO:0048643 ! positive regulation of skeletal muscle development +relationship: positively_regulates GO:0048630 ! skeletal muscle growth + +[Term] +id: GO:0048634 +name: regulation of muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007517 ! muscle development + +[Term] +id: GO:0048635 +name: negative regulation of muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] +synonym: "down regulation of muscle development" EXACT [] +synonym: "down-regulation of muscle development" EXACT [] +synonym: "downregulation of muscle development" EXACT [] +synonym: "inhibition of muscle development" NARROW [] +is_a: GO:0048634 ! regulation of muscle development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0007517 ! muscle development + +[Term] +id: GO:0048636 +name: positive regulation of muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] +synonym: "activation of muscle development" NARROW [] +synonym: "stimulation of muscle development" NARROW [] +synonym: "up regulation of muscle development" EXACT [] +synonym: "up-regulation of muscle development" EXACT [] +synonym: "upregulation of muscle development" EXACT [] +is_a: GO:0048634 ! regulation of muscle development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0007517 ! muscle development + +[Term] +id: GO:0048638 +name: regulation of developmental growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048589 ! developmental growth + +[Term] +id: GO:0048639 +name: positive regulation of developmental growth +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] +synonym: "activation of developmental growth" NARROW [] +synonym: "stimulation of developmental growth" NARROW [] +synonym: "up regulation of developmental growth" EXACT [] +synonym: "up-regulation of developmental growth" EXACT [] +synonym: "upregulation of developmental growth" EXACT [] +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0048589 ! developmental growth + +[Term] +id: GO:0048640 +name: negative regulation of developmental growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] +synonym: "down regulation of developmental growth" EXACT [] +synonym: "down-regulation of developmental growth" EXACT [] +synonym: "downregulation of developmental growth" EXACT [] +synonym: "inhibition of developmental growth" NARROW [] +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0048589 ! developmental growth + +[Term] +id: GO:0048641 +name: regulation of skeletal muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle development." [GOC:go_curators] +is_a: GO:0016202 ! regulation of striated muscle development +relationship: regulates GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0048642 +name: negative regulation of skeletal muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle development." [GOC:go_curators] +synonym: "down regulation of skeletal muscle development" EXACT [] +synonym: "down-regulation of skeletal muscle development" EXACT [] +synonym: "downregulation of skeletal muscle development" EXACT [] +synonym: "inhibition of skeletal muscle development" NARROW [] +is_a: GO:0045843 ! negative regulation of striated muscle development +is_a: GO:0048641 ! regulation of skeletal muscle development +relationship: negatively_regulates GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0048643 +name: positive regulation of skeletal muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of skeletal muscle development." [GOC:go_curators] +synonym: "activation of skeletal muscle development" NARROW [] +synonym: "stimulation of skeletal muscle development" NARROW [] +synonym: "up regulation of skeletal muscle development" EXACT [] +synonym: "up-regulation of skeletal muscle development" EXACT [] +synonym: "upregulation of skeletal muscle development" EXACT [] +is_a: GO:0045844 ! positive regulation of striated muscle development +is_a: GO:0048641 ! regulation of skeletal muscle development +relationship: positively_regulates GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0048644 +name: muscle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of muscle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0007517 ! muscle development + +[Term] +id: GO:0048645 +name: organ formation +namespace: biological_process +def: "The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jic] +synonym: "initiation of an organ primordium" NARROW [] +synonym: "organ primordium initiation" NARROW [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0048646 +name: anatomical structure formation +namespace: biological_process +def: "The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jic] +synonym: "formation of an anatomical structure" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0048647 +name: polyphenic determination +namespace: biological_process +def: "The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jic] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0048648 +name: caste determination +namespace: biological_process +def: "The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jic] +is_a: GO:0048647 ! polyphenic determination + +[Term] +id: GO:0048649 +name: caste determination, influence by genetic factors +namespace: biological_process +def: "The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jic] +is_a: GO:0048648 ! caste determination +is_a: GO:0048652 ! polyphenic determination, influence by genetic factors + +[Term] +id: GO:0048650 +name: caste determination, influence by environmental factors +namespace: biological_process +def: "The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jic] +is_a: GO:0048648 ! caste determination +is_a: GO:0048651 ! polyphenic determination, influence by environmental factors + +[Term] +id: GO:0048651 +name: polyphenic determination, influence by environmental factors +namespace: biological_process +def: "The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jic] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0048647 ! polyphenic determination + +[Term] +id: GO:0048652 +name: polyphenic determination, influence by genetic factors +namespace: biological_process +def: "The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jic] +is_a: GO:0048647 ! polyphenic determination + +[Term] +id: GO:0048653 +name: anther development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jic, GOC:sm] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048443 ! stamen development + +[Term] +id: GO:0048654 +name: anther morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the anther are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:sm] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048448 ! stamen morphogenesis +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0048655 +name: tapetal layer morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the tapetal layer are generated and organized. Morphogenesis pertains to the creation of form. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jic, GOC:sm] +synonym: "differentiation of tapetal layer" NARROW [] +synonym: "tapetum morphogenesis" EXACT [GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048654 ! anther morphogenesis +relationship: part_of GO:0048658 ! tapetal layer development + +[Term] +id: GO:0048656 +name: tapetal layer formation +namespace: biological_process +def: "The process that gives rise to the tapetal layer. This process pertains to the initial formation of a structure from unspecified parts. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jic, GOC:sm] +synonym: "tapetum formation" EXACT [GOC:tb] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048455 ! stamen formation +relationship: part_of GO:0048655 ! tapetal layer morphogenesis + +[Term] +id: GO:0048657 +name: tapetal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a tapetal cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jic, GOC:sm] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048656 ! tapetal layer formation + +[Term] +id: GO:0048658 +name: tapetal layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the tapetal layer over time, from its formation to the mature structure." [GOC:jic, GOC:sm] +synonym: "tapetum development" EXACT [GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0048659 +name: smooth muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] +synonym: "SMC proliferation" EXACT [] +is_a: GO:0033002 ! muscle cell proliferation + +[Term] +id: GO:0048660 +name: regulation of smooth muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] +synonym: "regulation of SMC proliferation" EXACT [] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:0048661 +name: positive regulation of smooth muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] +synonym: "activation of smooth muscle cell proliferation" NARROW [] +synonym: "positive regulation of SMC proliferation" EXACT [] +synonym: "stimulation of smooth muscle cell proliferation" NARROW [] +synonym: "up regulation of smooth muscle cell proliferation" EXACT [] +synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] +synonym: "upregulation of smooth muscle cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0048660 ! regulation of smooth muscle cell proliferation +relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:0048662 +name: negative regulation of smooth muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] +synonym: "down regulation of smooth muscle cell proliferation" EXACT [] +synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] +synonym: "downregulation of smooth muscle cell proliferation" EXACT [] +synonym: "inhibition of smooth muscle cell proliferation" NARROW [] +synonym: "negative regulation of SMC proliferation" EXACT [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0048660 ! regulation of smooth muscle cell proliferation +relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:0048663 +name: neuron fate commitment +namespace: biological_process +alt_id: GO:0042055 +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] +synonym: "neuron lineage restriction" EXACT [] +synonym: "neuronal lineage restriction" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030182 ! neuron differentiation + +[Term] +id: GO:0048664 +name: neuron fate determination +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0048663 ! neuron fate commitment + +[Term] +id: GO:0048665 +name: neuron fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048663 ! neuron fate commitment + +[Term] +id: GO:0048666 +name: neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030182 ! neuron differentiation + +[Term] +id: GO:0048667 +name: cell morphogenesis involved in neuron differentiation +namespace: biological_process +def: "The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] +synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0048668 +name: collateral sprouting +namespace: biological_process +def: "The process by which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0007409 ! axonogenesis + +[Term] +id: GO:0048669 +name: collateral sprouting in the absence of injury +namespace: biological_process +def: "The process by which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048670 +name: regulation of collateral sprouting +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0050770 ! regulation of axonogenesis +relationship: regulates GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048671 +name: negative regulation of collateral sprouting +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of collateral sprouting" EXACT [] +synonym: "down-regulation of collateral sprouting" EXACT [] +synonym: "downregulation of collateral sprouting" EXACT [] +synonym: "inhibition of collateral sprouting" NARROW [] +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0050771 ! negative regulation of axonogenesis +relationship: negatively_regulates GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048672 +name: positive regulation of collateral sprouting +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of collateral sprouting" NARROW [] +synonym: "stimulation of collateral sprouting" NARROW [] +synonym: "up regulation of collateral sprouting" EXACT [] +synonym: "up-regulation of collateral sprouting" EXACT [] +synonym: "upregulation of collateral sprouting" EXACT [] +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0050772 ! positive regulation of axonogenesis +relationship: positively_regulates GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048673 +name: collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "The process by which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jic] +is_a: GO:0031103 ! axon regeneration +is_a: GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048674 +name: collateral sprouting of injured axon +namespace: biological_process +def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process by which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048668 ! collateral sprouting +is_a: GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048675 +name: axon extension +namespace: biological_process +def: "Long distance growth of a single process." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0007409 ! axonogenesis + +[Term] +id: GO:0048676 +name: axon extension involved in development +namespace: biological_process +def: "Long distance growth of a single axon process involved in cellular development." [GOC:jic] +is_a: GO:0048675 ! axon extension + +[Term] +id: GO:0048677 +name: axon extension involved in regeneration +namespace: biological_process +def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jic] +is_a: GO:0048675 ! axon extension +is_a: GO:0048682 ! sprouting of injured axon +relationship: part_of GO:0031103 ! axon regeneration + +[Term] +id: GO:0048678 +name: response to axon injury +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0048679 +name: regulation of axon regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0050770 ! regulation of axonogenesis +relationship: regulates GO:0031103 ! axon regeneration + +[Term] +id: GO:0048680 +name: positive regulation of axon regeneration +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of axon regeneration" NARROW [] +synonym: "stimulation of axon regeneration" NARROW [] +synonym: "up regulation of axon regeneration" EXACT [] +synonym: "up-regulation of axon regeneration" EXACT [] +synonym: "upregulation of axon regeneration" EXACT [] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0048679 ! regulation of axon regeneration +is_a: GO:0050772 ! positive regulation of axonogenesis +relationship: positively_regulates GO:0031103 ! axon regeneration + +[Term] +id: GO:0048681 +name: negative regulation of axon regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of axon regeneration" EXACT [] +synonym: "down-regulation of axon regeneration" EXACT [] +synonym: "downregulation of axon regeneration" EXACT [] +synonym: "inhibition of axon regeneration" NARROW [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0048679 ! regulation of axon regeneration +is_a: GO:0050771 ! negative regulation of axonogenesis +relationship: negatively_regulates GO:0031103 ! axon regeneration + +[Term] +id: GO:0048682 +name: sprouting of injured axon +namespace: biological_process +def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0031103 ! axon regeneration + +[Term] +id: GO:0048683 +name: regulation of collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0048679 ! regulation of axon regeneration +relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury + +[Term] +id: GO:0048684 +name: positive regulation of collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW [] +synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW [] +synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT [] +is_a: GO:0048672 ! positive regulation of collateral sprouting +is_a: GO:0048680 ! positive regulation of axon regeneration +is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury +relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury + +[Term] +id: GO:0048685 +name: negative regulation of collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW [] +is_a: GO:0048671 ! negative regulation of collateral sprouting +is_a: GO:0048681 ! negative regulation of axon regeneration +is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury +relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury + +[Term] +id: GO:0048686 +name: regulation of sprouting of injured axon +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048679 ! regulation of axon regeneration +relationship: regulates GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048687 +name: positive regulation of sprouting of injured axon +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of sprouting of injured axon" NARROW [] +synonym: "stimulation of sprouting of injured axon" NARROW [] +synonym: "up regulation of sprouting of injured axon" EXACT [] +synonym: "up-regulation of sprouting of injured axon" EXACT [] +synonym: "upregulation of sprouting of injured axon" EXACT [] +is_a: GO:0048680 ! positive regulation of axon regeneration +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: positively_regulates GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048688 +name: negative regulation of sprouting of injured axon +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of sprouting of injured axon" EXACT [] +synonym: "down-regulation of sprouting of injured axon" EXACT [] +synonym: "downregulation of sprouting of injured axon" EXACT [] +synonym: "inhibition of sprouting of injured axon" NARROW [] +is_a: GO:0048681 ! negative regulation of axon regeneration +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: negatively_regulates GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048689 +name: formation of growth cone in injured axon +namespace: biological_process +def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048690 +name: regulation of axon extension involved in regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: regulates GO:0048677 ! axon extension involved in regeneration + +[Term] +id: GO:0048691 +name: positive regulation of axon extension involved in regeneration +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of axon extension involved in regeneration" NARROW [] +synonym: "stimulation of axon extension involved in regeneration" NARROW [] +synonym: "up regulation of axon extension involved in regeneration" EXACT [] +synonym: "up-regulation of axon extension involved in regeneration" EXACT [] +synonym: "upregulation of axon extension involved in regeneration" EXACT [] +is_a: GO:0045773 ! positive regulation of axon extension +is_a: GO:0048687 ! positive regulation of sprouting of injured axon +is_a: GO:0048690 ! regulation of axon extension involved in regeneration +relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration + +[Term] +id: GO:0048692 +name: negative regulation of axon extension involved in regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of axon extension involved in regeneration" EXACT [] +synonym: "down-regulation of axon extension involved in regeneration" EXACT [] +synonym: "downregulation of axon extension involved in regeneration" EXACT [] +synonym: "inhibition of axon extension involved in regeneration" NARROW [] +is_a: GO:0030517 ! negative regulation of axon extension +is_a: GO:0048688 ! negative regulation of sprouting of injured axon +is_a: GO:0048690 ! regulation of axon extension involved in regeneration +relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration + +[Term] +id: GO:0048693 +name: regulation of collateral sprouting of injured axon +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: regulates GO:0048674 ! collateral sprouting of injured axon + +[Term] +id: GO:0048694 +name: positive regulation of collateral sprouting of injured axon +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of collateral sprouting of injured axon" NARROW [] +synonym: "stimulation of collateral sprouting of injured axon" NARROW [] +synonym: "up regulation of collateral sprouting of injured axon" EXACT [] +synonym: "up-regulation of collateral sprouting of injured axon" EXACT [] +synonym: "upregulation of collateral sprouting of injured axon" EXACT [] +is_a: GO:0048672 ! positive regulation of collateral sprouting +is_a: GO:0048687 ! positive regulation of sprouting of injured axon +is_a: GO:0048693 ! regulation of collateral sprouting of injured axon +relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon + +[Term] +id: GO:0048695 +name: negative regulation of collateral sprouting of injured axon +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of collateral sprouting of injured axon" EXACT [] +synonym: "down-regulation of collateral sprouting of injured axon" EXACT [] +synonym: "downregulation of collateral sprouting of injured axon" EXACT [] +synonym: "inhibition of collateral sprouting of injured axon" NARROW [] +is_a: GO:0048671 ! negative regulation of collateral sprouting +is_a: GO:0048688 ! negative regulation of sprouting of injured axon +is_a: GO:0048693 ! regulation of collateral sprouting of injured axon +relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon + +[Term] +id: GO:0048696 +name: regulation of collateral sprouting in the absence of injury +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0048670 ! regulation of collateral sprouting +relationship: regulates GO:0048669 ! collateral sprouting in the absence of injury + +[Term] +id: GO:0048697 +name: positive regulation of collateral sprouting in the absence of injury +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "activation of collateral sprouting in the absence of injury" NARROW [] +synonym: "stimulation of collateral sprouting in the absence of injury" NARROW [] +synonym: "up regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "upregulation of collateral sprouting in the absence of injury" EXACT [] +is_a: GO:0048672 ! positive regulation of collateral sprouting +is_a: GO:0048696 ! regulation of collateral sprouting in the absence of injury +relationship: positively_regulates GO:0048669 ! collateral sprouting in the absence of injury + +[Term] +id: GO:0048698 +name: negative regulation of collateral sprouting in the absence of injury +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm] +synonym: "down regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "downregulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "inhibition of collateral sprouting in the absence of injury" NARROW [] +is_a: GO:0048671 ! negative regulation of collateral sprouting +is_a: GO:0048696 ! regulation of collateral sprouting in the absence of injury +relationship: negatively_regulates GO:0048669 ! collateral sprouting in the absence of injury + +[Term] +id: GO:0048699 +name: generation of neurons +namespace: biological_process +def: "The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] +is_a: GO:0022008 ! neurogenesis + +[Term] +id: GO:0048700 +name: acquisition of desiccation tolerance +namespace: biological_process +def: "The process by which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jic, GOC:ki] +is_a: GO:0022611 ! dormancy process +relationship: part_of GO:0010162 ! seed dormancy + +[Term] +id: GO:0048701 +name: embryonic cranial skeleton morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of cranial skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:dsf, GOC:jic, PMID:16049113] +synonym: "embryonic cranium morphogenesis" EXACT [] +is_a: GO:0048704 ! embryonic skeletal system morphogenesis + +[Term] +id: GO:0048702 +name: embryonic neurocranium morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of neurocranium are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jic, PMID:16049113] +synonym: "embryonic braincase morphogenesis" EXACT [] +synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis + +[Term] +id: GO:0048703 +name: embryonic viscerocranium morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of viscerocranium are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jic, PMID:16049113] +synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis + +[Term] +id: GO:0048704 +name: embryonic skeletal system morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:dsf, GOC:jic, GOC:tb, PMID:16049113] +synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0048706 ! embryonic skeletal system development + +[Term] +id: GO:0048705 +name: skeletal system morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:dsf, GOC:jic, GOC:tb] +synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0001501 ! skeletal system development + +[Term] +id: GO:0048706 +name: embryonic skeletal system development +namespace: biological_process +def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jic, GOC:tb, PMID:16049113] +synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001501 ! skeletal system development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0048707 +name: instar larval or pupal morphogenesis +namespace: biological_process +def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_sensu, GOC:rc] +synonym: "larval or pupal morphogenesis (sensu Insecta)" EXACT [] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0048708 +name: astrocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0048709 +name: oligodendrocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0048710 +name: regulation of astrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0048711 +name: positive regulation of astrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "activation of astrocyte differentiation" NARROW [] +synonym: "stimulation of astrocyte differentiation" NARROW [] +synonym: "up regulation of astrocyte differentiation" EXACT [] +synonym: "up-regulation of astrocyte differentiation" EXACT [] +synonym: "upregulation of astrocyte differentiation" EXACT [] +is_a: GO:0045687 ! positive regulation of glial cell differentiation +is_a: GO:0048710 ! regulation of astrocyte differentiation +relationship: positively_regulates GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0048712 +name: negative regulation of astrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "down regulation of astrocyte differentiation" EXACT [] +synonym: "down-regulation of astrocyte differentiation" EXACT [] +synonym: "downregulation of astrocyte differentiation" EXACT [] +synonym: "inhibition of astrocyte differentiation" NARROW [] +is_a: GO:0045686 ! negative regulation of glial cell differentiation +is_a: GO:0048710 ! regulation of astrocyte differentiation +relationship: negatively_regulates GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0048713 +name: regulation of oligodendrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0048714 +name: positive regulation of oligodendrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "activation of oligodendrocyte differentiation" NARROW [] +synonym: "stimulation of oligodendrocyte differentiation" NARROW [] +synonym: "up regulation of oligodendrocyte differentiation" EXACT [] +synonym: "up-regulation of oligodendrocyte differentiation" EXACT [] +synonym: "upregulation of oligodendrocyte differentiation" EXACT [] +is_a: GO:0045687 ! positive regulation of glial cell differentiation +is_a: GO:0048713 ! regulation of oligodendrocyte differentiation +relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0048715 +name: negative regulation of oligodendrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "down regulation of oligodendrocyte differentiation" EXACT [] +synonym: "down-regulation of oligodendrocyte differentiation" EXACT [] +synonym: "downregulation of oligodendrocyte differentiation" EXACT [] +synonym: "inhibition of oligodendrocyte differentiation" NARROW [] +is_a: GO:0045686 ! negative regulation of glial cell differentiation +is_a: GO:0048713 ! regulation of oligodendrocyte differentiation +relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0048716 +name: labrum morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of labrum are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048726 ! labrum development + +[Term] +id: GO:0048717 +name: anterior cibarial plate morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of anterior cibarial plate are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048722 ! anterior cibarial plate development + +[Term] +id: GO:0048718 +name: fish trap bristle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of fish trap bristle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc] +is_a: GO:0008407 ! bristle morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048725 ! fish trap bristle development + +[Term] +id: GO:0048719 +name: epistomal sclerite morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of epistomal sclerite are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048724 ! epistomal sclerite development + +[Term] +id: GO:0048720 +name: posterior cibarial plate morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of posterior cibarial plate are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048727 ! posterior cibarial plate development + +[Term] +id: GO:0048721 +name: clypeus morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of clypeus are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048723 ! clypeus development + +[Term] +id: GO:0048722 +name: anterior cibarial plate development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048723 +name: clypeus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048724 +name: epistomal sclerite development +namespace: biological_process +def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048725 +name: fish trap bristle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fish trap bristle over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0022416 ! bristle development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048726 +name: labrum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048727 +name: posterior cibarial plate development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048728 +name: proboscis development +namespace: biological_process +alt_id: GO:0016349 +def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048729 +name: tissue morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009888 ! tissue development + +[Term] +id: GO:0048730 +name: epidermis morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the epidermis are generated and organized. Morphogenesis pertains to the creation of form. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jic, http://cancerweb.ncl.ac.uk/] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0008544 ! epidermis development + +[Term] +id: GO:0048731 +name: system development +namespace: biological_process +def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jic] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0048732 +name: gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jic] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0048733 +name: sebaceous gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jic] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0048734 +name: proboscis morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the proboscis are generated and organized. Morphogenesis pertains to the creation of form. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jic, GOC:rc] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0048728 ! proboscis development + +[Term] +id: GO:0048735 +name: haltere morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a haltere are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +relationship: part_of GO:0007481 ! haltere disc morphogenesis +relationship: part_of GO:0007482 ! haltere development + +[Term] +id: GO:0048736 +name: appendage development +namespace: biological_process +def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [GOC:jic, GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organismal development + +[Term] +id: GO:0048737 +name: imaginal disc-derived appendage development +namespace: biological_process +def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jic, GOC:mtg_sensu, GOC:rc] +synonym: "appendage development (sensu Endopterygota)" EXACT [] +is_a: GO:0048736 ! appendage development + +[Term] +id: GO:0048738 +name: cardiac muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm] +synonym: "heart muscle development" EXACT [] +is_a: GO:0014706 ! striated muscle development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0048739 +name: cardiac muscle fiber development +namespace: biological_process +def: "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm] +synonym: "cardiac muscle fibre development" EXACT [] +synonym: "heart muscle fiber development" RELATED [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048738 ! cardiac muscle development + +[Term] +id: GO:0048740 +name: striated muscle fiber development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle] +comment: This term was obsoleted because it is not needed. The striated term would only be needed if we needed to group skeletal and cardiac and as caridac does not hav efibers there is no need to to do this. Therefore the grouping term has been obsoleted. +synonym: "myogenesis" EXACT [] +synonym: "striated muscle fibre development" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048741 +name: skeletal muscle fiber development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibres are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jic, GOC:lm, GOC:mtg_muscle] +synonym: "skeletal muscle fibre development" EXACT [] +synonym: "skeletal myofiber development" EXACT [] +synonym: "skeletal myofibre development" EXACT [] +is_a: GO:0048747 ! muscle fiber development +relationship: part_of GO:0007519 ! skeletal muscle development + +[Term] +id: GO:0048742 +name: regulation of skeletal muscle fiber development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibres are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:mtg_muscle, GOC:sm] +synonym: "regulation of skeletal muscle fibre development" EXACT [] +synonym: "regulation of skeletal myofiber development" EXACT [] +synonym: "regulation of skeletal myofibre development" EXACT [] +is_a: GO:0048641 ! regulation of skeletal muscle development +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0048743 +name: positive regulation of skeletal muscle fiber development +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibres are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle] +synonym: "activation of skeletal muscle fiber development" NARROW [] +synonym: "positive regulation of skeletal muscle fibre development" EXACT [] +synonym: "positive regulation of skeletal myofiber development" EXACT [] +synonym: "positive regulation of skeletal myofibre development" EXACT [] +synonym: "stimulation of skeletal muscle fiber development" NARROW [] +synonym: "up regulation of skeletal muscle fiber development" EXACT [] +synonym: "up-regulation of skeletal muscle fiber development" EXACT [] +synonym: "upregulation of skeletal muscle fiber development" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0048643 ! positive regulation of skeletal muscle development +is_a: GO:0048742 ! regulation of skeletal muscle fiber development +relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0048744 +name: negative regulation of skeletal muscle fiber development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibres are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle] +synonym: "down regulation of skeletal muscle fiber development" EXACT [] +synonym: "down-regulation of skeletal muscle fiber development" EXACT [] +synonym: "downregulation of skeletal muscle fiber development" EXACT [] +synonym: "inhibition of skeletal muscle fiber development" NARROW [] +synonym: "negative regulation of skeletal muscle fibre development" EXACT [] +synonym: "negative regulation of skeletal myofiber development" EXACT [] +synonym: "negative regulation of skeletal myofibre development" EXACT [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0048742 ! regulation of skeletal muscle fiber development +relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development +relationship: part_of GO:0048642 ! negative regulation of skeletal muscle development + +[Term] +id: GO:0048745 +name: smooth muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm] +is_a: GO:0007517 ! muscle development + +[Term] +id: GO:0048746 +name: smooth muscle fiber development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle] +comment: This term has been obsoleted because smooth muscle does not have fibers, it only has cells. +synonym: "smooth muscle fibre development" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048747 +name: muscle fiber development +namespace: biological_process +def: "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. Muscle fibres are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle] +synonym: "muscle fibre development" EXACT [] +synonym: "myofiber development" EXACT [] +synonym: "myofibre development" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007517 ! muscle development + +[Term] +id: GO:0048749 +name: compound eye development +namespace: biological_process +alt_id: GO:0007456 +def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure." [GOC:jic, GOC:mtg_sensu] +synonym: "compound eye development (sensu Endopterygota)" EXACT [] +synonym: "eye development (sensu Endopterygota)" EXACT [] +synonym: "insect-type retina development" EXACT [PMID:11735386] +is_a: GO:0001654 ! eye development + +[Term] +id: GO:0048750 +name: compound eye corneal lens morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the compound eye corneal lens are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +synonym: "corneal lens morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001745 ! compound eye morphogenesis +relationship: part_of GO:0048058 ! compound eye corneal lens development + +[Term] +id: GO:0048752 +name: semicircular canal morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the semicircular canals are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh, GOC:dph, GOC:jic] +synonym: "embryonic semicircular canal morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis + +[Term] +id: GO:0048753 +name: pigment granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] +subset: goslim_pir +synonym: "pigment granule organisation and biogenesis" EXACT [] +synonym: "pigment granule organization and biogenesis" EXACT [] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0033059 ! cellular pigmentation + +[Term] +id: GO:0048754 +name: branching morphogenesis of a tube +namespace: biological_process +def: "The process by which the anatomical structures of branches in a tube are generated and organized. Morphogenesis pertains to the creation of form. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jic] +is_a: GO:0001763 ! morphogenesis of a branching structure +is_a: GO:0035239 ! tube morphogenesis + +[Term] +id: GO:0048755 +name: branching morphogenesis of a nerve +namespace: biological_process +def: "The process by which the anatomical structures of branches in a nerve are generated and organized. Morphogenesis pertains to the creation of form. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jic] +is_a: GO:0001763 ! morphogenesis of a branching structure +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0048756 +name: sieve cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [CL:0000294, GOC:jic] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0010088 ! phloem histogenesis + +[Term] +id: GO:0048757 +name: pigment granule maturation +namespace: biological_process +def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jic, GOC:mh] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048758 +name: companion cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jic] +is_a: GO:0048760 ! parenchymal cell differentiation +relationship: part_of GO:0010088 ! phloem histogenesis + +[Term] +id: GO:0048759 +name: vessel member cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jic, PO:0002003] +synonym: "vessel element cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0010089 ! xylem histogenesis + +[Term] +id: GO:0048760 +name: parenchymal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasts. They vary in size, form, and wall structure." [CL:0000668, GOC:jic, ISBN:069716957X, PO:0005421] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048761 +name: collenchyma cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jic, http://cancerweb.ncl.ac.uk, PO:0000075] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048762 +name: mesenchymal cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell." [GOC:jic] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048763 +name: calcium-induced calcium release activity +namespace: molecular_function +def: "Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration." [GOC:jic, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752] +is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity + +[Term] +id: GO:0048764 +name: trichoblast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jic] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0010054 ! trichoblast differentiation + +[Term] +id: GO:0048765 +name: root hair cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jic] +is_a: GO:0048764 ! trichoblast maturation + +[Term] +id: GO:0048766 +name: root hair initiation +namespace: biological_process +def: "The process by which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jic, PMID:12468740] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0048765 ! root hair cell differentiation + +[Term] +id: GO:0048767 +name: root hair elongation +namespace: biological_process +def: "The process by which the root hair grows longer." [GOC:jic, PMID:12468740] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0048765 ! root hair cell differentiation + +[Term] +id: GO:0048768 +name: root hair cell tip growth +namespace: biological_process +def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jic, GOC:ki, PMID:12468740] +synonym: "root hair tip growth" EXACT [] +is_a: GO:0009932 ! cell tip growth +relationship: part_of GO:0048767 ! root hair elongation + +[Term] +id: GO:0048769 +name: sarcomerogenesis +namespace: biological_process +def: "The process by which sarcomeres are added in series within a fiber." [GOC:jic, GOC:lm, PMID:15947030] +synonym: "myofibril production" EXACT systematic_synonym [] +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0048770 +name: pigment granule +namespace: cellular_component +def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jic, GOC:mh] +is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0048771 +name: tissue remodeling +namespace: biological_process +def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0048772 +name: leucophore differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jic, GOC:mh] +synonym: "leucophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048773 +name: erythrophore differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jic, GOC:mh] +synonym: "erythrophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048774 +name: cyanophore differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jic, GOC:mh] +synonym: "cyanophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048775 +name: regulation of leucophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0048772 ! leucophore differentiation + +[Term] +id: GO:0048776 +name: negative regulation of leucophore differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh] +synonym: "down regulation of leucophore differentiation" EXACT [] +synonym: "down-regulation of leucophore differentiation" EXACT [] +synonym: "downregulation of leucophore differentiation" EXACT [] +synonym: "inhibition of leucophore differentiation" NARROW [] +is_a: GO:0048775 ! regulation of leucophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0048772 ! leucophore differentiation + +[Term] +id: GO:0048777 +name: positive regulation of leucophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh] +synonym: "activation of leucophore differentiation" NARROW [] +synonym: "stimulation of leucophore differentiation" NARROW [] +synonym: "up regulation of leucophore differentiation" EXACT [] +synonym: "up-regulation of leucophore differentiation" EXACT [] +synonym: "upregulation of leucophore differentiation" EXACT [] +is_a: GO:0048775 ! regulation of leucophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0048772 ! leucophore differentiation + +[Term] +id: GO:0048778 +name: regulation of erythrophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0048773 ! erythrophore differentiation + +[Term] +id: GO:0048779 +name: negative regulation of erythrophore differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh] +synonym: "down regulation of erythrophore differentiation" EXACT [] +synonym: "down-regulation of erythrophore differentiation" EXACT [] +synonym: "downregulation of erythrophore differentiation" EXACT [] +synonym: "inhibition of erythrophore differentiation" NARROW [] +is_a: GO:0048778 ! regulation of erythrophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0048773 ! erythrophore differentiation + +[Term] +id: GO:0048780 +name: positive regulation of erythrophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh] +synonym: "activation of erythrophore differentiation" NARROW [] +synonym: "stimulation of erythrophore differentiation" NARROW [] +synonym: "up regulation of erythrophore differentiation" EXACT [] +synonym: "up-regulation of erythrophore differentiation" EXACT [] +synonym: "upregulation of erythrophore differentiation" EXACT [] +is_a: GO:0048778 ! regulation of erythrophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0048773 ! erythrophore differentiation + +[Term] +id: GO:0048781 +name: regulation of cyanophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0048774 ! cyanophore differentiation + +[Term] +id: GO:0048782 +name: negative regulation of cyanophore differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh] +synonym: "down regulation of cyanophore differentiation" EXACT [] +synonym: "down-regulation of cyanophore differentiation" EXACT [] +synonym: "downregulation of cyanophore differentiation" EXACT [] +synonym: "inhibition of cyanophore differentiation" NARROW [] +is_a: GO:0048781 ! regulation of cyanophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0048774 ! cyanophore differentiation + +[Term] +id: GO:0048783 +name: positive regulation of cyanophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh] +synonym: "activation of cyanophore differentiation" NARROW [] +synonym: "stimulation of cyanophore differentiation" NARROW [] +synonym: "up regulation of cyanophore differentiation" EXACT [] +synonym: "up-regulation of cyanophore differentiation" EXACT [] +synonym: "upregulation of cyanophore differentiation" EXACT [] +is_a: GO:0048781 ! regulation of cyanophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0048774 ! cyanophore differentiation + +[Term] +id: GO:0048784 +name: pigment biosynthetic process during pigment granule maturation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pigment, during the process by which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jic] +is_a: GO:0046148 ! pigment biosynthetic process +relationship: part_of GO:0048757 ! pigment granule maturation + +[Term] +id: GO:0048785 +name: hatching gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jic] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0048786 +name: presynaptic active zone +namespace: cellular_component +def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:3152289] +is_a: GO:0044456 ! synapse part + +[Term] +id: GO:0048787 +name: presynaptic active zone membrane +namespace: cellular_component +def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289] +synonym: "active zone presynaptic plasma membrane" EXACT [] +is_a: GO:0042734 ! presynaptic membrane +relationship: part_of GO:0048786 ! presynaptic active zone + +[Term] +id: GO:0048788 +name: presynaptic cytoskeletal matrix assembled at active zones +namespace: cellular_component +def: "The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:10944438] +synonym: "CAZ" NARROW [] +synonym: "presynaptic cytomatrix assembled at active zones" EXACT [] +is_a: GO:0030863 ! cortical cytoskeleton +is_a: GO:0044456 ! synapse part +relationship: part_of GO:0048786 ! presynaptic active zone + +[Term] +id: GO:0048789 +name: cytoskeletal matrix organization at active zone +namespace: biological_process +def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jic, PMID:12812759] +is_a: GO:0030865 ! cortical cytoskeleton organization + +[Term] +id: GO:0048790 +name: maintenance of presynaptic active zone structure +namespace: biological_process +def: "The process by which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators] +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0048791 +name: calcium ion-dependent exocytosis of neurotransmitter +namespace: biological_process +def: "The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0048792 +name: calcium ion-independent exocytosis of neurotransmitter +namespace: biological_process +def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0048793 +name: pronephros development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. The pronephros is the first of the embryonic kidneys to be established and is the simplest vertebrate excretory organ." [GOC:bf, PMID:15968585] +is_a: GO:0001822 ! kidney development + +[Term] +id: GO:0048794 +name: swim bladder development +namespace: biological_process +def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder development" EXACT [] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0048795 +name: swim bladder morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of the swim bladder is generated and organized. Morphogenesis pertains to the creation of form. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder morphogenesis" EXACT [] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0048794 ! swim bladder development + +[Term] +id: GO:0048796 +name: swim bladder maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol] +synonym: "gas bladder maturation" EXACT [] +is_a: GO:0048799 ! organ maturation +relationship: part_of GO:0048794 ! swim bladder development + +[Term] +id: GO:0048797 +name: swim bladder formation +namespace: biological_process +def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder biosynthesis" EXACT [] +synonym: "gas bladder formation" EXACT [] +is_a: GO:0048645 ! organ formation +relationship: part_of GO:0048795 ! swim bladder morphogenesis + +[Term] +id: GO:0048798 +name: swim bladder inflation +namespace: biological_process +def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder inflation" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048796 ! swim bladder maturation + +[Term] +id: GO:0048799 +name: organ maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0048513 ! organ development + +[Term] +id: GO:0048800 +name: antennal morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of antenna are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis +relationship: part_of GO:0007469 ! antennal development + +[Term] +id: GO:0048801 +name: antennal joint morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the antennal joint are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048098 ! antennal joint development +relationship: part_of GO:0048800 ! antennal morphogenesis + +[Term] +id: GO:0048802 +name: notum morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of dorsal part of the body are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007472 ! wing disc morphogenesis +relationship: part_of GO:0007477 ! notum development + +[Term] +id: GO:0048803 +name: imaginal disc-derived male genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc. Morphogenesis pertains to the creation of form." [GOC:ai, GOC:sensu] +synonym: "male genital morphogenesis (sensu Endopterygota)" RELATED [] +synonym: "male genitalia morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis +is_a: GO:0048808 ! male genitalia morphogenesis +relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development + +[Term] +id: GO:0048804 +name: imaginal disc-derived female genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of female genitalia are generated and organized from the genital disc. Morphogenesis pertains to the creation of form." [GOC:ai, GOC:sensu] +synonym: "female genital morphogenesis (sensu Endopterygota)" EXACT [] +synonym: "female genitalia morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis +is_a: GO:0048807 ! female genitalia morphogenesis +relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development + +[Term] +id: GO:0048805 +name: imaginal disc-derived genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of genitalia are generated and organized from the genital imaginal disc. Morphogenesis pertains to the creation of form." [GOC:ai, GOC:sensu] +synonym: "genital morphogenesis (sensu Endopterygota)" RELATED [] +synonym: "genitalia morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0035112 ! genitalia morphogenesis +relationship: part_of GO:0007483 ! genital disc morphogenesis +relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development + +[Term] +id: GO:0048806 +name: genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jic] +synonym: "genital development" EXACT [] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0048807 +name: female genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of female genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mah] +synonym: "female genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +relationship: part_of GO:0030540 ! female genitalia development + +[Term] +id: GO:0048808 +name: male genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of male genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888] +synonym: "male genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +relationship: part_of GO:0030539 ! male genitalia development + +[Term] +id: GO:0048809 +name: analia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of analia are generated and organized. Morphogenesis pertains to the creation of form. The analia is the posterior-most vertral appendage that develops from the genital disc. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [GOC:ai, GOC:mtg_sensu] +synonym: "analia morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007483 ! genital disc morphogenesis +relationship: part_of GO:0007487 ! analia development + +[Term] +id: GO:0048810 +name: female analia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [GOC:mtg_sensu, PMID:11494318] +synonym: "female analia morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0048809 ! analia morphogenesis +relationship: part_of GO:0045497 ! female analia development + +[Term] +id: GO:0048811 +name: male analia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. Morphogenesis pertains to the creation of form. As in, but not restricted to, the Holometabola (Endopterygota, ncbi_taxonomy_id:33392)." [GOC:mtg_sensu, PMID:11494318] +synonym: "male analia morphogenesis (sensu Endopterygota)" EXACT [] +is_a: GO:0048809 ! analia morphogenesis +relationship: part_of GO:0045496 ! male analia development + +[Term] +id: GO:0048812 +name: neurite morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of neurites are generated and organized. Morphogenesis pertains to the creation of form. A neurite is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] +synonym: "neurite biosynthesis" NARROW [] +synonym: "neurite formation" NARROW [] +synonym: "neurite growth" NARROW [] +is_a: GO:0048858 ! cell projection morphogenesis +relationship: part_of GO:0031175 ! neurite development +relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation + +[Term] +id: GO:0048813 +name: dendrite morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0048812 ! neurite morphogenesis +relationship: part_of GO:0016358 ! dendrite development + +[Term] +id: GO:0048814 +name: regulation of dendrite morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0050773 ! regulation of dendrite development +relationship: regulates GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0048815 +name: hermaphrodite genitalia morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of hermaphrodite genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888] +is_a: GO:0035112 ! genitalia morphogenesis +relationship: part_of GO:0040035 ! hermaphrodite genitalia development + +[Term] +id: GO:0048816 +name: ocellus morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the ocellus are generated and organized. Morphogenesis pertains to the creation of form. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis +relationship: part_of GO:0008056 ! ocellus development + +[Term] +id: GO:0048817 +name: negative regulation of hair follicle maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] +synonym: "down regulation of hair follicle maturation" EXACT [] +synonym: "down-regulation of hair follicle maturation" EXACT [] +synonym: "downregulation of hair follicle maturation" EXACT [] +synonym: "inhibition of hair follicle maturation" NARROW [] +is_a: GO:0048819 ! regulation of hair follicle maturation +is_a: GO:0051799 ! negative regulation of hair follicle development +relationship: negatively_regulates GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0048818 +name: positive regulation of hair follicle maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] +synonym: "activation of hair follicle maturation" NARROW [] +synonym: "stimulation of hair follicle maturation" NARROW [] +synonym: "up regulation of hair follicle maturation" EXACT [] +synonym: "up-regulation of hair follicle maturation" EXACT [] +synonym: "upregulation of hair follicle maturation" EXACT [] +is_a: GO:0048819 ! regulation of hair follicle maturation +is_a: GO:0051798 ! positive regulation of hair follicle development +relationship: positively_regulates GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0048819 +name: regulation of hair follicle maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] +is_a: GO:0051797 ! regulation of hair follicle development +relationship: regulates GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0048820 +name: hair follicle maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0022405 ! hair cycle process +relationship: part_of GO:0001942 ! hair follicle development + +[Term] +id: GO:0048821 +name: erythrocyte development +namespace: biological_process +def: "The process aimed at the progression of an erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0048822 +name: enucleate erythrocyte development +namespace: biological_process +def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] +is_a: GO:0048821 ! erythrocyte development +relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation + +[Term] +id: GO:0048823 +name: nucleate erythrocyte development +namespace: biological_process +def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] +is_a: GO:0048821 ! erythrocyte development +relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation + +[Term] +id: GO:0048824 +name: pigment cell precursor differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899] +synonym: "chromatophore precursor differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048825 +name: cotyledon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, http://cancerweb.ncl.ac.uk] +is_a: GO:0009793 ! embryonic development ending in seed dormancy +is_a: GO:0048827 ! phyllome development + +[Term] +id: GO:0048826 +name: cotyledon morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the cotyledon are generated and organized. Morphogenesis pertains to the creation of form. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, http://cancerweb.ncl.ac.uk] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048825 ! cotyledon development + +[Term] +id: GO:0048827 +name: phyllome development +namespace: biological_process +def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048367 ! shoot development + +[Term] +id: GO:0048829 +name: root cap development +namespace: biological_process +def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0048830 +name: adventitious root development +namespace: biological_process +def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb] +is_a: GO:0048364 ! root development + +[Term] +id: GO:0048831 +name: regulation of shoot development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048367 ! shoot development + +[Term] +id: GO:0048832 +name: specification of organ number +namespace: biological_process +def: "The regionalization process that modulates the quantity of a particular type of organ." [GOC:dph, GOC:isa_complete, GOC:tb] +is_a: GO:0003002 ! regionalization +is_a: GO:0050793 ! regulation of developmental process + +[Term] +id: GO:0048833 +name: specification of floral organ number +namespace: biological_process +def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb] +is_a: GO:0048832 ! specification of organ number +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048834 +name: specification of petal number +namespace: biological_process +def: "Any process that modulates the number of petals formed in a flower." [GOC:tb] +is_a: GO:0048833 ! specification of floral organ number +relationship: part_of GO:0048465 ! corolla development + +[Term] +id: GO:0048835 +name: specification of decreased petal number +namespace: biological_process +def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb] +is_a: GO:0048834 ! specification of petal number + +[Term] +id: GO:0048836 +name: specification of increased petal number +namespace: biological_process +def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb] +is_a: GO:0048834 ! specification of petal number + +[Term] +id: GO:0048837 +name: sorus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sorus over time, from its formation to the mature structure. A sorus is a mass of spores." [DDB_REF:2530 "DictyBase paper repository", GOC:devbiol, GOC:mtg_sensu] +synonym: "sorus biosynthesis" EXACT [] +synonym: "sorus formation" EXACT [] +synonym: "spore head biosynthesis" EXACT [] +synonym: "spore head formation" EXACT [] +synonym: "spore head morphogenesis" EXACT [] +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0031154 ! culmination during sorocarp development + +[Term] +id: GO:0048838 +name: release of seed from dormancy +namespace: biological_process +def: "The process by which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jic, GOC:tb] +is_a: GO:0022611 ! dormancy process +relationship: part_of GO:0010162 ! seed dormancy + +[Term] +id: GO:0048839 +name: inner ear development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043583 ! ear development + +[Term] +id: GO:0048840 +name: otolith development +namespace: biological_process +def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0048841 +name: regulation of axon extension involved in axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0051270 ! regulation of cell motion +relationship: regulates GO:0048846 ! axon extension involved in axon guidance + +[Term] +id: GO:0048842 +name: positive regulation of axon extension involved in axon guidance +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] +synonym: "activation of axon extension involved in axon guidance" NARROW [] +synonym: "stimulation of axon extension involved in axon guidance" NARROW [] +synonym: "up regulation of axon extension involved in axon guidance" EXACT [] +synonym: "up-regulation of axon extension involved in axon guidance" EXACT [] +synonym: "upregulation of axon extension involved in axon guidance" EXACT [] +is_a: GO:0045773 ! positive regulation of axon extension +is_a: GO:0048841 ! regulation of axon extension involved in axon guidance +relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance + +[Term] +id: GO:0048843 +name: negative regulation of axon extension involved in axon guidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] +synonym: "down regulation of axon extension involved in axon guidance" EXACT [] +synonym: "down-regulation of axon extension involved in axon guidance" EXACT [] +synonym: "downregulation of axon extension involved in axon guidance" EXACT [] +synonym: "inhibition of axon extension involved in axon guidance" NARROW [] +is_a: GO:0030517 ! negative regulation of axon extension +is_a: GO:0048841 ! regulation of axon extension involved in axon guidance +relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance + +[Term] +id: GO:0048844 +name: artery morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of arterial blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] +synonym: "arterial morphogenesis" EXACT [] +is_a: GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0048845 +name: venous blood vessel morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of venous blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] +synonym: "vein morphogenesis" BROAD [] +synonym: "venous morphogenesis" EXACT [] +is_a: GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0048846 +name: axon extension involved in axon guidance +namespace: biological_process +def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jic] +is_a: GO:0048675 ! axon extension +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:0048847 +name: adenohypophysis formation +namespace: biological_process +def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jic] +synonym: "adenophysis biosynthesis" EXACT [] +synonym: "adenophysis formation" EXACT [] +synonym: "anterior pituitary biosynthesis" EXACT [] +synonym: "anterior pituitary formation" EXACT [] +synonym: "anterior pituitary gland biosynthesis" EXACT [] +synonym: "anterior pituitary gland formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048855 ! adenohypophysis morphogenesis + +[Term] +id: GO:0048848 +name: neurohypophysis morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of neurohypophysis are generated and organized. Morphogenesis pertains to the creation of form. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic] +synonym: "neurophysis morphogenesis" EXACT [] +synonym: "posterior pituitary gland morphogenesis" EXACT [] +synonym: "posterior pituitary morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021985 ! neurohypophysis development +relationship: part_of GO:0048850 ! hypophysis morphogenesis + +[Term] +id: GO:0048849 +name: neurohypophysis formation +namespace: biological_process +def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic] +synonym: "neurophysis biosynthesis" EXACT [] +synonym: "neurophysis formation" EXACT [] +synonym: "posterior pituitary biosynthesis" EXACT [] +synonym: "posterior pituitary formation" EXACT [] +synonym: "posterior pituitary gland biosynthesis" EXACT [] +synonym: "posterior pituitary gland formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048848 ! neurohypophysis morphogenesis + +[Term] +id: GO:0048850 +name: hypophysis morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the hypophysis are generated and organized. Morphogenesis pertains to the creation of form. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic] +synonym: "pituitary gland morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021983 ! pituitary gland development +relationship: part_of GO:0048852 ! diencephalon morphogenesis + +[Term] +id: GO:0048851 +name: hypophysis formation +namespace: biological_process +def: "The process by which the anatomical structures of the hypophysis are generated and organized. Morphogenesis pertains to the creation of form. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic] +synonym: "hypophysis biosynthesis" EXACT [] +synonym: "pituitary gland biosynthesis" EXACT [] +synonym: "pituitary gland formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0048850 ! hypophysis morphogenesis + +[Term] +id: GO:0048852 +name: diencephalon morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of diencephalon are generated and organized. Morphogenesis pertains to the creation of form. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0048853 ! forebrain morphogenesis + +[Term] +id: GO:0048853 +name: forebrain morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the forebrain are generated and organized. Morphogenesis pertains to the creation of form. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jic] +synonym: "prosencephalon morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030900 ! forebrain development +relationship: part_of GO:0048854 ! brain morphogenesis + +[Term] +id: GO:0048854 +name: brain morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of brain are generated and organized. Morphogenesis pertains to the creation of form. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jic] +is_a: GO:0009887 ! organ morphogenesis +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0048855 +name: adenohypophysis morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the adenohypophysis are generated and organized. Morphogenesis pertains to the creation of form. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jic] +synonym: "adenophysis morphogenesis" EXACT [] +synonym: "anterior pituitary gland morphogenesis" EXACT [] +synonym: "anterior pituitary morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021984 ! adenohypophysis development +relationship: part_of GO:0048850 ! hypophysis morphogenesis + +[Term] +id: GO:0048856 +name: anatomical structure development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +synonym: "development of an anatomical structure" EXACT [] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0048857 +name: neural nucleus development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0048858 +name: cell projection morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0030030 ! cell projection organization +is_a: GO:0032990 ! cell part morphogenesis +relationship: part_of GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0048859 +name: formation of anatomical boundary +namespace: biological_process +def: "The process by which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:mtg_15jun06] +comment: This term was added by GO_REF:0000021. +is_a: GO:0048646 ! anatomical structure formation + +[Term] +id: GO:0048860 +name: glioblast cell division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0048861 +name: leukemia inhibitory factor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands." [GOC:devbiol] +synonym: "leukemia inhibitory factor signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0048863 +name: stem cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048864 +name: stem cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0048865 +name: stem cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0048866 +name: stem cell fate specification +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048865 ! stem cell fate commitment + +[Term] +id: GO:0048867 +name: stem cell fate determination +namespace: biological_process +def: "The process whereby a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0048865 ! stem cell fate commitment + +[Term] +id: GO:0048868 +name: pollen tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0048869 +name: cellular developmental process +namespace: biological_process +def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0048870 +name: cell motility +namespace: biological_process +def: "Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] +subset: gosubset_prok +is_a: GO:0006928 ! cell motion +relationship: part_of GO:0040011 ! locomotion + +[Term] +id: GO:0048871 +name: multicellular organismal homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium at the level of the multicellular organism." [GOC:isa_complete] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0048872 +name: homeostasis of number of cells +namespace: biological_process +def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells." [GOC:isa_complete] +synonym: "cell population homeostasis" EXACT [] +synonym: "homeostasis of cell number" EXACT [GOC:dph] +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0048873 +name: homeostasis of number of cells within a tissue +namespace: biological_process +def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells in a tissue." [GOC:isa_complete] +is_a: GO:0001894 ! tissue homeostasis +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0048874 +name: homeostasis of number of cells in a free-living population +namespace: biological_process +def: "The biological process involved in maintaining the equilibrium of cell number within a population of free-living cells such as the bacteria in the gut." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0048872 ! homeostasis of number of cells +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0048875 +name: chemical homeostasis within a tissue +namespace: biological_process +def: "Any process involved in the maintenance of the internal equilibrium of the amount of a chemical at the level of the tissue." [GOC:isa_complete] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0048876 +name: chemical homeostasis within retina +namespace: biological_process +def: "Any process involved in the maintenance of the internal equilibrium of the amount of a chemical at the level of the retina." [GOC:isa_complete] +is_a: GO:0001895 ! retina homeostasis +is_a: GO:0048875 ! chemical homeostasis within a tissue + +[Term] +id: GO:0048877 +name: homeostasis of number of retina cells +namespace: biological_process +def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb] +is_a: GO:0001895 ! retina homeostasis +is_a: GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0048878 +name: chemical homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal equilibrium of a chemical." [GOC:isa_complete] +subset: gosubset_prok +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0048880 +name: sensory system development +namespace: biological_process +def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0048881 +name: mechanosensory lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509] +synonym: "LL system development" EXACT [ISBN:0125296509] +is_a: GO:0048925 ! lateral line system development + +[Term] +id: GO:0048882 +name: lateral line development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509] +synonym: "LL development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048925 ! lateral line system development + +[Term] +id: GO:0048883 +name: neuromast primordium migration +namespace: biological_process +def: "The migration of a cluster of relatively undifferentiated cells originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385] +synonym: "lateral line primordium migration" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0048882 ! lateral line development + +[Term] +id: GO:0048884 +name: neuromast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] +is_a: GO:0007423 ! sensory organ development +relationship: part_of GO:0048882 ! lateral line development + +[Term] +id: GO:0048885 +name: neuromast deposition +namespace: biological_process +def: "The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940] +is_a: GO:0030336 ! negative regulation of cell migration +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048886 +name: neuromast hair cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509] +is_a: GO:0042490 ! mechanoreceptor differentiation +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048887 +name: cupula development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048888 +name: neuromast mantle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048889 +name: neuromast support cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048890 +name: lateral line ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377] +synonym: "gLL ganglion development" EXACT [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0007422 ! peripheral nervous system development +relationship: part_of GO:0048925 ! lateral line system development + +[Term] +id: GO:0048891 +name: lateral line ganglion neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940] +synonym: "gLL neuron differentiation" EXACT [] +is_a: GO:0048934 ! peripheral nervous system neuron differentiation +relationship: part_of GO:0048890 ! lateral line ganglion development + +[Term] +id: GO:0048892 +name: lateral line nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509] +synonym: "nLL development" EXACT [] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0048925 ! lateral line system development + +[Term] +id: GO:0048893 +name: afferent axon development in a lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385] +is_a: GO:0048936 ! peripheral nervous system neuron axonogenesis +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048894 +name: efferent axon development in a lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385] +is_a: GO:0021955 ! central nervous system neuron axonogenesis +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048895 +name: lateral line nerve glial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048896 +name: glial cell migration in a lateral line nerve +namespace: biological_process +def: "The movement of glial cells along the axons in a lateral line nerve." [PMID:12062041] +is_a: GO:0008347 ! glial cell migration +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048897 +name: myelination of lateral line nerve axons +namespace: biological_process +def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation + +[Term] +id: GO:0048898 +name: anterior lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] +synonym: "ALL system development" RELATED [] +is_a: GO:0048925 ! lateral line system development +relationship: part_of GO:0048881 ! mechanosensory lateral line system development + +[Term] +id: GO:0048899 +name: anterior lateral line development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] +synonym: "anterior LL development" EXACT [] +is_a: GO:0048882 ! lateral line development +relationship: part_of GO:0048898 ! anterior lateral line system development + +[Term] +id: GO:0048900 +name: anterior lateral line neuromast primordium migration +namespace: biological_process +def: "The migration of a cluster of relatively undifferentiated cells along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] +synonym: "ALL neuromast primordium migration" EXACT [] +is_a: GO:0048883 ! neuromast primordium migration +relationship: part_of GO:0048899 ! anterior lateral line development + +[Term] +id: GO:0048901 +name: anterior lateral line neuromast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] +is_a: GO:0048884 ! neuromast development +relationship: part_of GO:0048899 ! anterior lateral line development + +[Term] +id: GO:0048902 +name: anterior lateral line neuromast deposition +namespace: biological_process +def: "The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385] +is_a: GO:0048885 ! neuromast deposition +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048903 +name: anterior lateral line neuromast hair cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377] +is_a: GO:0048886 ! neuromast hair cell differentiation +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048904 +name: anterior lateral line neuromast cupula development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] +is_a: GO:0048887 ! cupula development +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048905 +name: anterior lateral line neuromast mantle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] +is_a: GO:0048888 ! neuromast mantle cell differentiation +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048906 +name: anterior lateral line neuromast support cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] +is_a: GO:0048889 ! neuromast support cell differentiation +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048907 +name: anterior lateral line ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] +synonym: "gALL development" EXACT [] +is_a: GO:0048890 ! lateral line ganglion development +relationship: part_of GO:0048898 ! anterior lateral line system development + +[Term] +id: GO:0048908 +name: anterior lateral line ganglion neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940] +is_a: GO:0048891 ! lateral line ganglion neuron differentiation +relationship: part_of GO:0048907 ! anterior lateral line ganglion development + +[Term] +id: GO:0048909 +name: anterior lateral line nerve development +namespace: biological_process +alt_id: GO:0021734 +def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0125296509] +comment: This term was added by GO_REF:0000021. +synonym: "ALLN development" EXACT [] +synonym: "nALL development" EXACT [] +synonym: "rostral lateral line nerve development" EXACT [] +is_a: GO:0048892 ! lateral line nerve development +relationship: part_of GO:0048898 ! anterior lateral line system development + +[Term] +id: GO:0048910 +name: afferent axon development in the anterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940] +is_a: GO:0048893 ! afferent axon development in a lateral line nerve +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048911 +name: efferent axon development in the anterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940] +is_a: GO:0048894 ! efferent axon development in a lateral line nerve +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048912 +name: glial cell migration in the anterior lateral line nerve +namespace: biological_process +def: "The movement of glial cells along the axons in the anterior lateral line nerve." [PMID:12062041] +is_a: GO:0048896 ! glial cell migration in a lateral line nerve +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048913 +name: anterior lateral line nerve glial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385] +is_a: GO:0048895 ! lateral line nerve glial cell differentiation +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048914 +name: myelination of anterior lateral line nerve axons +namespace: biological_process +def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375] +is_a: GO:0048897 ! myelination of lateral line nerve axons +relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation + +[Term] +id: GO:0048915 +name: posterior lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] +synonym: "PLL" RELATED [] +is_a: GO:0048925 ! lateral line system development +relationship: part_of GO:0048881 ! mechanosensory lateral line system development + +[Term] +id: GO:0048916 +name: posterior lateral line development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509] +synonym: "PLL development" EXACT [] +is_a: GO:0048882 ! lateral line development +relationship: part_of GO:0048915 ! posterior lateral line system development + +[Term] +id: GO:0048917 +name: posterior lateral line ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377] +synonym: "gPLL development" EXACT [] +is_a: GO:0048890 ! lateral line ganglion development +relationship: part_of GO:0048915 ! posterior lateral line system development + +[Term] +id: GO:0048918 +name: posterior lateral line nerve development +namespace: biological_process +alt_id: GO:0021733 +def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, form its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0125296509] +comment: This term was added by GO_REF:0000021. +synonym: "caudal lateral line nerve development" EXACT [] +synonym: "PLLN development" EXACT [] +is_a: GO:0048892 ! lateral line nerve development +relationship: part_of GO:0048915 ! posterior lateral line system development + +[Term] +id: GO:0048919 +name: posterior lateral line neuromast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] +is_a: GO:0048884 ! neuromast development +relationship: part_of GO:0048916 ! posterior lateral line development + +[Term] +id: GO:0048920 +name: posterior lateral line neuromast primordium migration +namespace: biological_process +def: "The migration of a cluster of relatively undifferentiated cells along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] +synonym: "PLL neuromast primordium migration" EXACT [] +is_a: GO:0048883 ! neuromast primordium migration +relationship: part_of GO:0048916 ! posterior lateral line development + +[Term] +id: GO:0048921 +name: posterior lateral line neuromast cupula development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] +is_a: GO:0048887 ! cupula development +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048922 +name: posterior lateral line neuromast deposition +namespace: biological_process +def: "The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385] +is_a: GO:0048885 ! neuromast deposition +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048923 +name: posterior lateral line neuromast hair cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509] +is_a: GO:0048886 ! neuromast hair cell differentiation +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048924 +name: posterior lateral line neuromast mantle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] +is_a: GO:0048888 ! neuromast mantle cell differentiation +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048925 +name: lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509] +is_a: GO:0048880 ! sensory system development + +[Term] +id: GO:0048926 +name: electrosensory lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0048925 ! lateral line system development + +[Term] +id: GO:0048927 +name: posterior lateral line neuromast support cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] +is_a: GO:0048889 ! neuromast support cell differentiation +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048928 +name: posterior lateral line ganglion neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940] +is_a: GO:0048891 ! lateral line ganglion neuron differentiation +relationship: part_of GO:0048917 ! posterior lateral line ganglion development + +[Term] +id: GO:0048929 +name: efferent axon development in the posterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940] +is_a: GO:0048894 ! efferent axon development in a lateral line nerve +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048930 +name: glial cell migration in the posterior lateral line nerve +namespace: biological_process +def: "The movement of glial cells along the axons in the posterior lateral line nerve." [PMID:12062041] +is_a: GO:0048896 ! glial cell migration in a lateral line nerve +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048931 +name: posterior lateral line nerve glial cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385] +is_a: GO:0048895 ! lateral line nerve glial cell differentiation +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048932 +name: myelination of posterior lateral line nerve axons +namespace: biological_process +def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375] +is_a: GO:0048897 ! myelination of lateral line nerve axons +relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation + +[Term] +id: GO:0048933 +name: afferent axon development in the posterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940] +is_a: GO:0048893 ! afferent axon development in a lateral line nerve +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048934 +name: peripheral nervous system neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0007422 ! peripheral nervous system development + +[Term] +id: GO:0048935 +name: peripheral nervous system neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation + +[Term] +id: GO:0048936 +name: peripheral nervous system neuron axonogenesis +namespace: biological_process +def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh] +is_a: GO:0007409 ! axonogenesis +relationship: part_of GO:0048935 ! peripheral nervous system neuron development + +[Term] +id: GO:0048937 +name: lateral line nerve glial cell development +namespace: biological_process +def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation + +[Term] +id: GO:0048938 +name: lateral line nerve glial cell morphogenesis involved in differentiation +namespace: biological_process +def: "The process by which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0048937 ! lateral line nerve glial cell development + +[Term] +id: GO:0048939 +name: anterior lateral line nerve glial cell development +namespace: biological_process +def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] +is_a: GO:0048937 ! lateral line nerve glial cell development +relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation + +[Term] +id: GO:0048940 +name: anterior lateral line nerve glial cell morphogenesis involved in differentiation +namespace: biological_process +def: "The process by which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh] +is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation +relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development + +[Term] +id: GO:0048941 +name: posterior lateral line nerve glial cell development +namespace: biological_process +def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] +is_a: GO:0048937 ! lateral line nerve glial cell development +relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation + +[Term] +id: GO:0048942 +name: posterior lateral line nerve glial cell morphogenesis involved in differentiation +namespace: biological_process +def: "The process by which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh] +is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation +relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development + +[Term] +id: GO:0050000 +name: chromosome localization +namespace: biological_process +def: "Any process by which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of chromosome localization" EXACT [] +synonym: "establishment and maintenance of chromosome position" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0050001 +name: D-glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN] +synonym: "D-glutamine amidohydrolase activity" EXACT [EC:3.5.1.35] +xref: EC:3.5.1.35 +xref: MetaCyc:D-GLUTAMINASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050002 +name: D-proline reductase (dithiol) activity +namespace: molecular_function +def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN] +comment: Note that this function was formerly EC:1.4.4.1. +synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" EXACT [EC:1.21.4.1] +xref: EC:1.21.4.1 +xref: MetaCyc:1.21.4.1-RXN +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0050003 +name: deoxycytidylate C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = deoxy-5-methylcytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN] +synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" EXACT [EC:2.1.1.54] +synonym: "dCMP methyltransferase activity" EXACT [EC:2.1.1.54] +synonym: "deoxycytidylate methyltransferase activity" EXACT [EC:2.1.1.54] +xref: EC:2.1.1.54 +xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN +is_a: GO:0008169 ! C-methyltransferase activity + +[Term] +id: GO:0050004 +name: isoflavone 7-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] +synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] +synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170] +synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] +synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170] +xref: EC:2.4.1.170 +xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050005 +name: isohexenylglutaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + H2O." [EC:4.2.1.57, MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.57] +synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" EXACT [EC:4.2.1.57] +synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" EXACT [EC:4.2.1.57] +synonym: "isohexenylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.57] +xref: EC:4.2.1.57 +xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN +xref: UM-BBD_enzymeID:e0722 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050006 +name: isomaltulose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN] +synonym: "isomaltulose synthetase activity" EXACT [EC:5.4.99.11] +synonym: "sucrose alpha-glucosyltransferase activity" EXACT [EC:5.4.99.11] +synonym: "sucrose glucosylmutase activity" EXACT [EC:5.4.99.11] +synonym: "trehalulose synthase activity" EXACT [EC:5.4.99.11] +xref: EC:5.4.99.11 +xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0050007 +name: isonocardicin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + nocardicin E = 5'-methylthioadenosine + isonocardicin A." [EC:2.5.1.38, MetaCyc:ISONOCARDICIN-SYNTHASE-RXN] +synonym: "nocardicin aminocarboxypropyltransferase activity" EXACT [EC:2.5.1.38] +synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.38] +xref: EC:2.5.1.38 +xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050008 +name: isopiperitenone delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN] +synonym: "isopiperitenone D-isomerase activity" EXACT [] +synonym: "isopiperitenone delta8-delta4-isomerase activity" EXACT [EC:5.3.3.11] +xref: EC:5.3.3.11 +xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050009 +name: isopropanol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: propan-2-ol + NADP+ = acetone + NADPH." [EC:1.1.1.80, MetaCyc:ISOPROPANOL-DEHYDROGENASE-(NADP+)-RXN] +synonym: "propan-2-ol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.80] +xref: EC:1.1.1.80 +xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050010 +name: isovitexin beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + isovitexin = isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "isovitexin b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] +synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106] +synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.106] +xref: EC:2.4.1.106 +xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050011 +name: itaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN] +synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" EXACT [EC:4.2.1.56] +synonym: "citramalyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.56] +synonym: "itaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.56] +xref: EC:4.2.1.56 +xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050012 +name: juglone 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + donor-H2 + O2 = 3,5-dihydroxy-1,4-naphthoquinone + acceptor + H2O." [EC:1.14.99.27, MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN] +synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.99.27] +synonym: "juglone hydroxylase activity" EXACT [] +synonym: "naphthoquinone hydroxylase activity" EXACT [EC:1.14.99.27] +synonym: "naphthoquinone-hydroxylase activity" EXACT [EC:1.14.99.27] +xref: EC:1.14.99.27 +xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050013 +name: 2-dehydropantoate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN] +synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.1.2.12] +synonym: "2-dehydropantoate formaldehyde-lyase activity" EXACT [EC:4.1.2.12] +synonym: "ketopantoaldolase activity" EXACT [] +xref: EC:4.1.2.12 +xref: MetaCyc:KETOPANTOALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050014 +name: ketotetrose-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: erythrulose 1-phosphate = glycerone phosphate + formaldehyde." [EC:4.1.2.2, MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN] +synonym: "erythrose-1-phosphate synthase activity" EXACT [EC:4.1.2.2] +synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.2] +synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" EXACT [EC:4.1.2.2] +synonym: "erythrulose-1-phosphate synthetase activity" EXACT [EC:4.1.2.2] +synonym: "phosphoketotetrose aldolase activity" EXACT [EC:4.1.2.2] +xref: EC:4.1.2.2 +xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050015 +name: kievitone hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: kievitone hydrate = kievitone + H2O." [EC:4.2.1.95, MetaCyc:KIEVITONE-HYDRATASE-RXN] +synonym: "KHase activity" EXACT [EC:4.2.1.95] +synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" EXACT [EC:4.2.1.95] +synonym: "kievitone-hydrate hydro-lyase activity" EXACT [EC:4.2.1.95] +xref: EC:4.2.1.95 +xref: MetaCyc:KIEVITONE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050016 +name: kynurenine 7,8-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-7\,8-HYDROXYLASE-RXN] +synonym: "kynurenate 7,8-hydroxylase activity" EXACT [EC:1.14.99.2] +synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.2] +synonym: "kynurenic acid hydroxylase activity" EXACT [EC:1.14.99.2] +synonym: "kynurenic hydroxylase activity" EXACT [EC:1.14.99.2] +xref: EC:1.14.99.2 +xref: MetaCyc:KYNURENINE-7\,8-HYDROXYLASE-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050017 +name: L-3-cyanoalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN] +synonym: "beta-cyano-L-alanine synthase activity" EXACT [EC:4.4.1.9] +synonym: "beta-cyanoalanine synthase activity" EXACT [EC:4.4.1.9] +synonym: "beta-cyanoalanine synthetase activity" EXACT [EC:4.4.1.9] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" EXACT [EC:4.4.1.9] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" EXACT [EC:4.4.1.9] +xref: EC:4.4.1.9 +xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050018 +name: L-amino-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN] +synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.5] +xref: EC:1.4.1.5 +xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050019 +name: L-arabinitol 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + NADH." [EC:1.1.1.12, MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN] +xref: EC:1.1.1.12 +xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050020 +name: L-arabinonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O." [EC:4.2.1.25, MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN] +synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" EXACT [EC:4.2.1.25] +synonym: "L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.25] +synonym: "L-arabonate dehydrase activity" EXACT [EC:4.2.1.25] +synonym: "L-arabonate dehydratase activity" EXACT [EC:4.2.1.25] +xref: EC:4.2.1.25 +xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050021 +name: L-arabinonolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate." [EC:3.1.1.15, MetaCyc:L-ARABINONOLACTONASE-RXN] +synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.15] +xref: EC:3.1.1.15 +xref: MetaCyc:L-ARABINONOLACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050022 +name: L-arabinose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN] +synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.46] +xref: EC:1.1.1.46 +xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050023 +name: L-fuconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O." [EC:4.2.1.68, MetaCyc:L-FUCONATE-HYDRATASE-RXN] +synonym: "L-fuconate hydratase activity" EXACT [] +synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" EXACT [EC:4.2.1.68] +synonym: "L-fuconate hydro-lyase activity" EXACT [EC:4.2.1.68] +xref: EC:4.2.1.68 +xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050024 +name: L-galactonolactone oxidase activity +namespace: molecular_function +alt_id: GO:0033733 +def: "Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2." [EC:1.3.3.12, MetaCyc:L-GALACTONOLACTONE-OXIDASE-RXN] +synonym: "L-galactono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] +synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.3.3.12] +synonym: "L-xylono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12] +xref: EC:1.3.3.12 +xref: MetaCyc:L-GALACTONOLACTONE-OXIDASE-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050025 +name: L-glutamate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN] +subset: gosubset_prok +synonym: "glutamate (acceptor) dehydrogenase activity" EXACT [EC:1.4.3.11] +synonym: "glutamate oxidase activity" EXACT [EC:1.4.3.11] +synonym: "glutamic acid oxidase activity" EXACT [EC:1.4.3.11] +synonym: "glutamic dehydrogenase (acceptor)" EXACT [EC:1.4.3.11] +synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.11] +synonym: "L-glutamic acid oxidase activity" EXACT [EC:1.4.3.11] +xref: EC:1.4.3.11 +xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0050026 +name: L-glycol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN] +synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.185] +synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.185] +synonym: "L-glycol:NAD(P) dehydrogenase activity" EXACT [EC:1.1.1.185] +synonym: "L-glycol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.185] +xref: EC:1.1.1.185 +xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050027 +name: L-idonate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [EC:1.1.1.128, MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN] +synonym: "5-keto-D-gluconate 2-reductase activity" EXACT [EC:1.1.1.128] +synonym: "5-ketogluconate 2-reductase activity" EXACT [EC:1.1.1.128] +synonym: "5-ketoglucono-idono-reductase activity" EXACT [EC:1.1.1.128] +synonym: "5KGR" RELATED [EC:1.1.1.128] +synonym: "L-idonate dehydrogenase activity" EXACT [EC:1.1.1.128] +synonym: "L-idonate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.128] +synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" EXACT [EC:1.1.1.128] +xref: EC:1.1.1.128 +xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050028 +name: L-lysine-lactamase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine 1,6-lactam + H2O = L-lysine." [EC:3.5.2.11, MetaCyc:L-LYSINE-LACTAMASE-RXN] +synonym: "L-alpha-aminocaprolactam hydrolase activity" EXACT [EC:3.5.2.11] +synonym: "L-lysinamidase activity" EXACT [EC:3.5.2.11] +synonym: "L-lysine-1,6-lactam lactamhydrolase activity" EXACT [EC:3.5.2.11] +xref: EC:3.5.2.11 +xref: MetaCyc:L-LYSINE-LACTAMASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0050029 +name: L-lysine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2." [EC:1.4.3.14, MetaCyc:L-LYSINE-OXIDASE-RXN] +synonym: "L-lysine alpha-oxidase activity" EXACT [EC:1.4.3.14] +synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" EXACT [EC:1.4.3.14] +synonym: "L-lysyl-alpha-oxidase activity" EXACT [EC:1.4.3.14] +xref: EC:1.4.3.14 +xref: MetaCyc:L-LYSINE-OXIDASE-RXN +xref: MetaCyc:PWY-5311 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0050030 +name: L-pipecolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-pipecolate + acceptor = 2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN] +synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] +synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3] +xref: EC:1.5.99.3 +xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0050031 +name: L-pipecolate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2." [EC:1.5.3.7, MetaCyc:L-PIPECOLATE-OXIDASE-RXN] +synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" EXACT [EC:1.5.3.7] +synonym: "L-pipecolic acid oxidase activity" EXACT [EC:1.5.3.7] +xref: EC:1.5.3.7 +xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0050032 +name: L-rhamnonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O." [EC:4.2.1.90, MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN] +synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" EXACT [EC:4.2.1.90] +synonym: "L-rhamnonate hydro-lyase activity" EXACT [EC:4.2.1.90] +xref: EC:4.2.1.90 +xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050033 +name: L-rhamnono-1,4-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate." [EC:3.1.1.65, MetaCyc:L-RHAMNONO-1\,4-LACTONASE-RXN] +synonym: "L-rhamno-gamma-lactonase activity" EXACT [EC:3.1.1.65] +synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.65] +synonym: "L-rhamnono-gamma-lactonase activity" EXACT [EC:3.1.1.65] +xref: EC:3.1.1.65 +xref: MetaCyc:L-RHAMNONO-1\,4-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050034 +name: L-rhamnose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamno-1,4-lactone + NADH." [EC:1.1.1.173, MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN] +synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.173] +xref: EC:1.1.1.173 +xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050035 +name: L-sorbose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2." [EC:1.1.3.11, MetaCyc:L-SORBOSE-OXIDASE-RXN] +synonym: "L-sorbose:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.11] +xref: EC:1.1.3.11 +xref: MetaCyc:L-SORBOSE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050036 +name: L-threonate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + NADH." [EC:1.1.1.129, MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN] +synonym: "L-threonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.129] +synonym: "L-threonic acid dehydrogenase activity" EXACT [EC:1.1.1.129] +synonym: "threonate dehydrogenase activity" EXACT [EC:1.1.1.129] +xref: EC:1.1.1.129 +xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050037 +name: L-xylose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-xylose + NADP+ = L-xylono-1,4-lactone + NADPH." [EC:1.1.1.113, MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN] +synonym: "L-xylose dehydrogenase activity" EXACT [EC:1.1.1.113] +synonym: "L-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.113] +synonym: "NADPH-xylose reductase activity" EXACT [EC:1.1.1.113] +xref: EC:1.1.1.113 +xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050038 +name: L-xylulose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: xylitol + NADP+ = L-xylulose + NADPH." [EC:1.1.1.10, MetaCyc:L-XYLULOSE-REDUCTASE-RXN] +xref: EC:1.1.1.10 +xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050039 +name: lactaldehyde reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,2-diol + NADP+ = L-lactaldehyde + NADPH." [EC:1.1.1.55, MetaCyc:LACTALDEHYDE-REDUCTASE-(NADPH)-RXN] +synonym: "1,2-propanediol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] +synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.55] +synonym: "NADP-1,2-propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] +synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55] +synonym: "propanediol dehydrogenase activity" EXACT [EC:1.1.1.55] +xref: EC:1.1.1.55 +xref: MetaCyc:LACTALDEHYDE-REDUCTASE-(NADPH)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050040 +name: lactate 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O." [EC:1.13.12.4, MetaCyc:LACTATE-2-MONOOXYGENASE-RXN] +subset: gosubset_prok +synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.4] +synonym: "L-lactate monooxygenase activity" EXACT [EC:1.13.12.4] +synonym: "L-lactate-2-monooxygenase activity" EXACT [EC:1.13.12.4] +synonym: "lactate monooxygenase activity" EXACT [EC:1.13.12.4] +synonym: "lactate oxidase activity" EXACT [EC:1.13.12.4] +synonym: "lactate oxidative decarboxylase activity" EXACT [EC:1.13.12.4] +synonym: "lactate oxygenase activity" EXACT [EC:1.13.12.4] +synonym: "lactic oxidase activity" EXACT [EC:1.13.12.4] +synonym: "lactic oxygenase activity" EXACT [EC:1.13.12.4] +xref: EC:1.13.12.4 +xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050041 +name: lactate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate = formate + acetaldehyde." [EC:4.1.2.36, MetaCyc:LACTATE-ALDOLASE-RXN] +synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" EXACT [EC:4.1.2.36] +synonym: "(S)-lactate acetaldehyde-lyase activity" EXACT [EC:4.1.2.36] +synonym: "lactate synthase activity" EXACT [EC:4.1.2.36] +xref: EC:4.1.2.36 +xref: MetaCyc:LACTATE-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050042 +name: lactate-malate transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = pyruvate + malate." [EC:1.1.99.7, MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN] +synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" EXACT [EC:1.1.99.7] +synonym: "malate-lactate transhydrogenase activity" EXACT [EC:1.1.99.7] +xref: EC:1.1.99.7 +xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050043 +name: lactate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, MetaCyc:LACTATE-RACEMASE-RXN] +synonym: "hydroxyacid racemase activity" EXACT [EC:5.1.2.1] +synonym: "lactic acid racemase activity" EXACT [EC:5.1.2.1] +synonym: "lacticoracemase activity" EXACT [EC:5.1.2.1] +xref: EC:5.1.2.1 +xref: MetaCyc:LACTATE-RACEMASE-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0050044 +name: galactose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN] +subset: gosubset_prok +synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.26] +synonym: "D-galactose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.26] +xref: EC:5.3.1.26 +xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0050045 +name: laminaribiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN] +synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.31] +xref: EC:2.4.1.31 +xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0050046 +name: lathosterol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN] +synonym: "5-DES" RELATED [EC:1.14.21.6] +synonym: "5alpha-cholest-7-en-3beta-ol, NAD(P)H:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.21.6] +synonym: "delta7-sterol 5-desaturase activity" EXACT [EC:1.14.21.6] +synonym: "delta7-sterol delta5-dehydrogenase activity" EXACT [EC:1.14.21.6] +synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6] +synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6] +xref: EC:1.14.21.6 +xref: MetaCyc:LATHOSTEROL-OXIDASE-RXN +is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated + +[Term] +id: GO:0050047 +name: leucine 2,3-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-alpha-leucine = (3R)-beta-leucine." [EC:5.4.3.7, MetaCyc:LEUCINE-2\,3-AMINOMUTASE-RXN] +synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" EXACT [EC:5.4.3.7] +xref: EC:5.4.3.7 +xref: MetaCyc:LEUCINE-2\,3-AMINOMUTASE-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0050048 +name: leucine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN] +synonym: "L-leucine aminotransferase activity" EXACT [EC:2.6.1.6] +synonym: "L-leucine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.6] +synonym: "leucine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.6] +synonym: "leucine aminotransferase activity" EXACT [] +synonym: "leucine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.6] +xref: EC:2.6.1.6 +xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050049 +name: leucine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "L-leucine dehydrogenase activity" EXACT [EC:1.4.1.9] +synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.9] +synonym: "L-leucine:NAD+ oxidoreductase, deaminating" EXACT [EC:1.4.1.9] +synonym: "LeuDH activity" EXACT [EC:1.4.1.9] +xref: EC:1.4.1.9 +xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050050 +name: leucine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-leucine = CoA + N-acetyl-L-leucine." [EC:2.3.1.66, MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" EXACT [EC:2.3.1.66] +synonym: "leucine acetyltransferase activity" EXACT [EC:2.3.1.66] +xref: EC:2.3.1.66 +xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0050051 +name: leukotriene-B4 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN] +synonym: "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.30] +synonym: "leucotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "leukotriene-B(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "leukotriene-B(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "leukotriene-B4 20-hydroxylase activity" EXACT [] +synonym: "leukotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "LTB(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "LTB(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "LTB4 20-hydroxylase activity" EXACT [EC:1.14.13.30] +synonym: "LTB4 omega-hydroxylase activity" EXACT [EC:1.14.13.30] +xref: EC:1.14.13.30 +xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050052 +name: leukotriene-E4 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leucotriene E4 + NADP+ + H2O." [EC:1.14.13.34, MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN] +synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.34] +synonym: "leukotriene-E(4) omega-hydroxylase activity" EXACT [EC:1.14.13.34] +synonym: "leukotriene-E4 omega-hydroxylase activity" EXACT [EC:1.14.13.34] +synonym: "leukotriene-E4 w-hydroxylase activity" EXACT [] +xref: EC:1.14.13.34 +xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050053 +name: levansucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN] +subset: gosubset_prok +synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" EXACT [EC:2.4.1.10] +synonym: "beta-2,6-fructosyltransferase activity" EXACT [EC:2.4.1.10] +synonym: "sucrose 6-fructosyl transferase activity" EXACT [EC:2.4.1.10] +synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10] +synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10] +xref: EC:2.4.1.10 +xref: MetaCyc:LEVANSUCRASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050054 +name: lignostilbene alpha beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethene + O2 = 2 vanillin." [EC:1.13.11.43, MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN] +synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" EXACT [EC:1.13.11.43] +synonym: "lignostilbene ab-dioxygenase activity" EXACT [] +synonym: "lignostilbene alphabeta-dioxygenase activity" EXACT [EC:1.13.11.43] +xref: EC:1.13.11.43 +xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050055 +name: limonin-D-ring-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN] +synonym: "limonin lactone hydrolase activity" EXACT [EC:3.1.1.36] +synonym: "limonin-D-ring-lactone hydrolase activity" EXACT [EC:3.1.1.36] +synonym: "limonoate-D-ring-lactone lactonohydrolase activity" EXACT [EC:3.1.1.36] +xref: EC:3.1.1.36 +xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050056 +name: linalool 8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,7-dimethylocta-1,6-dien-3-ol + donor-H2 + O2 = (E)-3,7-dimethylocta-1,6-dien-3,8-diol + acceptor + H2O." [EC:1.14.99.28, MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN] +subset: gosubset_prok +synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.99.28] +xref: EC:1.14.99.28 +xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050057 +name: linamarin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN] +synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] +synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] +synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63] +synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] +synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63] +synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63] +synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" EXACT [EC:2.4.1.63] +xref: EC:2.4.1.63 +xref: MetaCyc:LINAMARIN-SYNTHASE-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050058 +name: linoleate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-cis,12-cis-octadecadienoate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, MetaCyc:LINOLEATE-ISOMERASE-RXN] +synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" EXACT [EC:5.2.1.5] +synonym: "linoleic acid isomerase activity" EXACT [EC:5.2.1.5] +xref: EC:5.2.1.5 +xref: MetaCyc:LINOLEATE-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050059 +name: lombricine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN] +synonym: "ATP:lombricine N-phosphotransferase activity" EXACT [EC:2.7.3.5] +xref: EC:2.7.3.5 +xref: MetaCyc:LOMBRICINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0050060 +name: long-chain-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN] +synonym: "fatty alcohol oxidoreductase activity" EXACT [EC:1.1.1.192] +synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192] +synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192] +xref: EC:1.1.1.192 +xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050061 +name: long-chain-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN] +synonym: "fatty aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] +synonym: "long-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] +synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48] +synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48] +xref: EC:1.2.1.48 +xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN +xref: UM-BBD_enzymeID:e0874 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050062 +name: long-chain-fatty-acyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "acyl coenzyme A reductase activity" EXACT [EC:1.2.1.50] +synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50] +xref: EC:1.2.1.50 +xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050063 +name: low-density-lipoprotein-receptor kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN] +synonym: "[low-density lipoprotein receptor] kinase activity" EXACT [] +synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] +synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29] +synonym: "LDL receptor kinase activity" EXACT [EC:2.7.11.29] +synonym: "low-density lipoprotein receptor kinase activity" EXACT [EC:2.7.11.29] +synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29] +synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.29] +synonym: "STK7" RELATED [EC:2.7.11.29] +xref: EC:2.7.11.29 +xref: MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050064 +name: luteolin 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate + luteolin = UDP + luteolin 7-O-beta-D-glucuronide." [EC:2.4.1.189, MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN] +synonym: "LGT" RELATED [EC:2.4.1.189] +synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT [] +synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] +synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] +synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189] +xref: EC:2.4.1.189 +xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050065 +name: lysine-pyruvate 6-transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + pyruvate = 2-aminoadipate 6-semialdehyde + L-alanine." [EC:2.6.1.71, MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN] +synonym: "L-lysine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] +synonym: "Lys-AT" RELATED [EC:2.6.1.71] +synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT [] +synonym: "lysine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.71] +xref: EC:2.6.1.71 +xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN +xref: MetaCyc:PWY-5324 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050066 +name: lysine 2,3-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, MetaCyc:LYSINE-2\,3-AMINOMUTASE-RXN] +subset: gosubset_prok +synonym: "L-lysine 2,3-aminomutase activity" EXACT [EC:5.4.3.2] +xref: EC:5.4.3.2 +xref: MetaCyc:LYSINE-2\,3-AMINOMUTASE-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0050067 +name: lysine 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O." [EC:1.13.12.2, MetaCyc:LYSINE-2-MONOOXYGENASE-RXN] +synonym: "L-lysine-2-monooxygenase activity" EXACT [EC:1.13.12.2] +synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.2] +synonym: "lysine monooxygenase activity" EXACT [EC:1.13.12.2] +synonym: "lysine oxygenase activity" EXACT [EC:1.13.12.2] +xref: EC:1.13.12.2 +xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050068 +name: lysine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + L-lysine = phosphate + L-homocitrulline." [EC:2.1.3.8, MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN] +synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" EXACT [EC:2.1.3.8] +synonym: "lysine transcarbamylase activity" EXACT [EC:2.1.3.8] +xref: EC:2.1.3.8 +xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0050069 +name: lysine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN] +synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" EXACT [EC:1.4.1.15] +xref: EC:1.4.1.15 +xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050070 +name: lysolecithin acylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-lysolecithin = 3-lysolecithin." [EC:5.4.1.1, MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN] +synonym: "lysolecithin 2,3-acylmutase activity" EXACT [EC:5.4.1.1] +synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1] +xref: EC:5.4.1.1 +xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0050071 +name: lysyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT [EC:2.3.2.3] +synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3] +xref: EC:2.3.2.3 +xref: MetaCyc:LYSYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0050072 +name: m7G(5')pppN diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M(7)G(5')PPPN-PYROPHOSPHATASE-RXN] +synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30] +synonym: "decapase activity" RELATED [EC:3.6.1.30] +synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT [] +synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30] +xref: EC:3.6.1.30 +xref: MetaCyc:M(7)G(5')PPPN-PYROPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0050073 +name: macrolide 2'-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + oleandomycin = ADP + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, MetaCyc:MACROLIDE-2'-KINASE-RXN] +synonym: "ATP:macrolide 2'-O-phosphotransferase activity" EXACT [EC:2.7.1.136] +xref: EC:2.7.1.136 +xref: MetaCyc:MACROLIDE-2'-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050074 +name: malate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN] +subset: gosubset_prok +synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9] +synonym: "malate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.9] +synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9] +synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9] +xref: EC:6.2.1.9 +xref: MetaCyc:MALATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050075 +name: maleate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-malate = maleate + H2O." [EC:4.2.1.31, MetaCyc:MALEATE-HYDRATASE-RXN] +synonym: "(R)-malate hydro-lyase (maleate-forming)" EXACT [EC:4.2.1.31] +synonym: "(R)-malate hydro-lyase activity" EXACT [EC:4.2.1.31] +synonym: "D-malate hydro-lyase activity" EXACT [EC:4.2.1.31] +synonym: "malease activity" EXACT [EC:4.2.1.31] +xref: EC:4.2.1.31 +xref: MetaCyc:MALEATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050076 +name: maleate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, MetaCyc:MALEATE-ISOMERASE-RXN] +subset: gosubset_prok +synonym: "maleate cis-trans-isomerase activity" EXACT [EC:5.2.1.1] +xref: EC:5.2.1.1 +xref: MetaCyc:MALEATE-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050077 +name: maleylpyruvate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN] +subset: gosubset_prok +synonym: "3-maleylpyruvate cis-trans-isomerase activity" EXACT [EC:5.2.1.4] +xref: EC:5.2.1.4 +xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050078 +name: malonate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, MetaCyc:MALONATE-COA-TRANSFERASE-RXN] +synonym: "acetyl-CoA:malonate CoA-transferase activity" EXACT [EC:2.8.3.3] +synonym: "malonate coenzyme A-transferase activity" EXACT [EC:2.8.3.3] +xref: EC:2.8.3.3 +xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0050079 +name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate +namespace: molecular_function +alt_id: GO:0047607 +def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN] +comment: Note that this function was formerly EC:4.2.1.71. +synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" EXACT [EC:4.2.1.27] +synonym: "3-oxopropanoate hydro-lyase activity" EXACT [EC:4.2.1.27] +synonym: "acetylenecarboxylate hydratase activity" BROAD [] +synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT [] +synonym: "acetylenemonocarboxylate hydrase activity" EXACT [EC:4.2.1.27] +synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] +synonym: "acetylmonocarboxylic acid hydrase activity" EXACT [EC:4.2.1.27] +synonym: "alkynoate hydratase activity" BROAD [] +synonym: "malonate-semialdehyde dehydratase activity" EXACT [] +xref: EC:4.2.1.27 +xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050080 +name: malonyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN] +subset: gosubset_prok +synonym: "malonyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.9] +synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.1.9] +synonym: "malonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.9] +xref: EC:4.1.1.9 +xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050081 +name: maltose-6'-phosphate glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6'-PHOSPHATE-GLUCOSIDASE-RXN] +subset: gosubset_prok +synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" EXACT [EC:3.2.1.122] +synonym: "phospho-alpha-glucosidase activity" EXACT [EC:3.2.1.122] +xref: EC:3.2.1.122 +xref: MetaCyc:MALTOSE-6'-PHOSPHATE-GLUCOSIDASE-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0050082 +name: maltose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN] +subset: gosubset_prok +synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.8] +xref: EC:2.4.1.8 +xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0050083 +name: malyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN] +synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.24] +synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" EXACT [EC:4.1.3.24] +synonym: "malyl-coenzyme A lyase activity" EXACT [EC:4.1.3.24] +xref: EC:4.1.3.24 +xref: MetaCyc:MALYL-COA-LYASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0050084 +name: mannitol-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + phosphate." [EC:3.1.3.22, MetaCyc:MANNITOL-1-PHOSPHATASE-RXN] +synonym: "D-mannitol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.22] +synonym: "mannitol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.22] +xref: EC:3.1.3.22 +xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050085 +name: mannitol 2-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + NADPH." [EC:1.1.1.138, MetaCyc:MANNITOL-2-DEHYDROGENASE-(NADP+)-RXN] +synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.138] +synonym: "NADP-dependent mannitol dehydrogenase activity" EXACT [EC:1.1.1.138] +xref: EC:1.1.1.138 +xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050086 +name: mannitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "D-mannitol dehydrogenase activity" EXACT [EC:1.1.1.67] +synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.67] +xref: EC:1.1.1.67 +xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050087 +name: mannitol dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-(CYTOCHROME)-RXN] +synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.2] +synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2] +xref: EC:1.1.2.2 +xref: MetaCyc:MANNITOL-DEHYDROGENASE-(CYTOCHROME)-RXN +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0050088 +name: mannose-6-phosphate 6-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH." [EC:1.1.1.224, MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN] +synonym: "6-phosphomannose reductase activity" EXACT [EC:1.1.1.224] +synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.224] +synonym: "mannose-6-phosphate reductase activity" EXACT [EC:1.1.1.224] +synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" EXACT [EC:1.1.1.224] +synonym: "NADPH-dependent M6P reductase activity" EXACT [EC:1.1.1.224] +synonym: "NADPH-dependent mannose 6-phosphate reductase activity" EXACT [EC:1.1.1.224] +synonym: "NADPH-mannose-6-P reductase activity" EXACT [EC:1.1.1.224] +xref: EC:1.1.1.224 +xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050089 +name: mannose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, MetaCyc:MANNOSE-ISOMERASE-RXN] +synonym: "D-mannose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.7] +synonym: "D-mannose isomerase activity" EXACT [EC:5.3.1.7] +synonym: "D-mannose ketol-isomerase activity" EXACT [EC:5.3.1.7] +xref: EC:5.3.1.7 +xref: MetaCyc:MANNOSE-ISOMERASE-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0050090 +name: mannuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN] +synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.131] +synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" EXACT [EC:1.1.1.131] +synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" EXACT [EC:1.1.1.131] +synonym: "mannonate dehydrogenase (NAD(P)+)" EXACT [EC:1.1.1.131] +synonym: "mannonate dehydrogenase activity" EXACT [EC:1.1.1.131] +xref: EC:1.1.1.131 +xref: MetaCyc:MANNURONATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050091 +name: melilotate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O." [EC:1.14.13.4, MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN] +synonym: "2-hydroxyphenylpropionate hydroxylase activity" EXACT [EC:1.14.13.4] +synonym: "2-hydroxyphenylpropionic hydroxylase activity" EXACT [EC:1.14.13.4] +synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.4] +synonym: "melilotate hydroxylase activity" EXACT [] +synonym: "melilotic hydroxylase activity" EXACT [EC:1.14.13.4] +xref: EC:1.14.13.4 +xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050092 +name: meso-tartrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: meso-tartrate + NAD+ = dihydroxyfumarate + NADH." [EC:1.3.1.7, MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN] +synonym: "meso-tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.7] +xref: EC:1.3.1.7 +xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050093 +name: methanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanol + NAD+ = formaldehyde + NADH." [EC:1.1.1.244, MetaCyc:METHANOL-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "methanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.244] +xref: EC:1.1.1.244 +xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050094 +name: methionine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN] +synonym: "L-methionine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] +synonym: "methionine-glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73] +synonym: "MGAT activity" EXACT [EC:2.6.1.73] +xref: EC:2.6.1.73 +xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050095 +name: methionine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine = 3-methylthiopropanamine + CO2." [EC:4.1.1.57, MetaCyc:METHIONINE-DECARBOXYLASE-RXN] +synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" EXACT [EC:4.1.1.57] +synonym: "L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.57] +synonym: "L-methionine decarboxylase activity" EXACT [EC:4.1.1.57] +xref: EC:4.1.1.57 +xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050096 +name: methylaspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threo-3-methylaspartate = mesaconate + NH3." [EC:4.3.1.2, MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN] +subset: gosubset_prok +synonym: "3-methylaspartase activity" EXACT [EC:4.3.1.2] +synonym: "beta-methylaspartase activity" EXACT [EC:4.3.1.2] +synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" EXACT [EC:4.3.1.2] +synonym: "L-threo-3-methylaspartate ammonia-lyase activity" EXACT [EC:4.3.1.2] +xref: EC:4.3.1.2 +xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0050097 +name: methylaspartate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threo-3-methylaspartate = L-glutamate." [EC:5.4.99.1, MetaCyc:METHYLASPARTATE-MUTASE-RXN] +subset: gosubset_prok +synonym: "b-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] +synonym: "beta-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1] +synonym: "glutamate isomerase activity" EXACT [EC:5.4.99.1] +synonym: "glutamate mutase activity" EXACT [EC:5.4.99.1] +synonym: "glutamic acid isomerase activity" EXACT [EC:5.4.99.1] +synonym: "glutamic acid mutase activity" EXACT [EC:5.4.99.1] +synonym: "glutamic isomerase activity" EXACT [EC:5.4.99.1] +synonym: "glutamic mutase activity" EXACT [EC:5.4.99.1] +synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" EXACT [EC:5.4.99.1] +synonym: "methylaspartic acid mutase activity" EXACT [EC:5.4.99.1] +xref: EC:5.4.99.1 +xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0050098 +name: methylguanidinase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylguanidine + H2O = methylamine + urea." [EC:3.5.3.16, MetaCyc:METHYLGUANIDINASE-RXN] +synonym: "methylguanidine amidinohydrolase activity" EXACT [EC:3.5.3.16] +synonym: "methylguanidine hydrolase activity" EXACT [EC:3.5.3.16] +xref: EC:3.5.3.16 +xref: MetaCyc:METHYLGUANIDINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050099 +name: methylglutamate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor." [EC:1.5.99.5, MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN] +synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] +synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.5] +synonym: "N-methylglutamate dehydrogenase activity" EXACT [EC:1.5.99.5] +xref: EC:1.5.99.5 +xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0050100 +name: methylitaconate delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylitaconate = dimethylmaleate." [EC:5.3.3.6, MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN] +synonym: "methylitaconate D-isomerase activity" EXACT [] +synonym: "methylitaconate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.6] +synonym: "methylitaconate isomerase activity" EXACT [EC:5.3.3.6] +xref: EC:5.3.3.6 +xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050101 +name: mimosinase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, MetaCyc:MIMOSINASE-RXN] +synonym: "mimosine amidohydrolase activity" EXACT [EC:3.5.1.61] +xref: EC:3.5.1.61 +xref: MetaCyc:MIMOSINASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050102 +name: cellodextrin phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN] +subset: gosubset_prok +synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.49] +synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49] +xref: EC:2.4.1.49 +xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0050103 +name: dextrin dextranase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN] +synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.2] +synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2] +synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2] +xref: EC:2.4.1.2 +xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050104 +name: L-gulonate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH." [EC:1.1.1.45, MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "L-3-aldonate dehydrogenase activity" EXACT [EC:1.1.1.45] +synonym: "L-3-aldonic dehydrogenase activity" EXACT [EC:1.1.1.45] +synonym: "L-3-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] +synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" EXACT [EC:1.1.1.45] +synonym: "L-beta-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45] +synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.45] +synonym: "L-gulonic acid dehydrogenase activity" EXACT [EC:1.1.1.45] +xref: EC:1.1.1.45 +xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050105 +name: L-gulonolactone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN] +subset: gosubset_prok +synonym: "GLO activity" EXACT [EC:1.1.3.8] +synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.8] +synonym: "L-gulono-gamma-lactone oxidase activity" EXACT [EC:1.1.3.8] +synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" EXACT [EC:1.1.3.8] +synonym: "L-gulono-gamma-lactone:oxidoreductase activity" EXACT [EC:1.1.3.8] +xref: EC:1.1.3.8 +xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050106 +name: monomethyl-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: monomethyl sulfate + H2O = methanol + SO4(2-) (sulfate)." [EC:3.1.6.16, MetaCyc:MONOMETHYL-SULFATASE-RXN] +synonym: "monomethyl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.16] +synonym: "monomethyl-sulphatase activity" EXACT [] +xref: EC:3.1.6.16 +xref: MetaCyc:MONOMETHYL-SULFATASE-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0050107 +name: monoterpenol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" EXACT [EC:2.3.1.69] +synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69] +xref: EC:2.3.1.69 +xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050108 +name: monoterpenyl-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN] +synonym: "bornyl diphosphate hydrolase activity" EXACT [EC:3.1.7.3] +synonym: "bornyl pyrophosphate hydrolase activity" EXACT [EC:3.1.7.3] +synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.3] +synonym: "monoterpenyl-pyrophosphatase activity" EXACT [] +xref: EC:3.1.7.3 +xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0050109 +name: morphine 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.218] +synonym: "naloxone reductase activity" EXACT [EC:1.1.1.218] +synonym: "reductase, naloxone" EXACT [EC:1.1.1.218] +xref: EC:1.1.1.218 +xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050110 +name: mucinaminylserine mucinaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [EC:3.2.1.110, MetaCyc:MUCINAMINYLSERINE-MUCINAMINIDASE-RXN] +synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" EXACT [EC:3.2.1.110] +synonym: "endo-alpha-N-acetyl-D-galactosaminidase activity" EXACT [EC:3.2.1.110] +synonym: "endo-alpha-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110] +xref: EC:3.2.1.110 +xref: MetaCyc:MUCINAMINYLSERINE-MUCINAMINIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050111 +name: mycocerosate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+ = multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+." [EC:2.3.1.111, MetaCyc:MYCOCEROSATE-SYNTHASE-RXN] +synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" EXACT [EC:2.3.1.111] +synonym: "mycocerosic acid synthase activity" EXACT [EC:2.3.1.111] +xref: EC:2.3.1.111 +xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050112 +name: inositol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH." [EC:1.1.1.18, MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "myo-inositol 2-dehydrogenase activity" EXACT [] +xref: EC:1.1.1.18 +xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN +is_a: GO:0004033 ! aldo-keto reductase activity + +[Term] +id: GO:0050113 +name: inositol oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O." [EC:1.13.99.1, MetaCyc:MYO-INOSITOL-OXYGENASE-RXN] +synonym: "meso-inositol oxygenase activity" EXACT [EC:1.13.99.1] +synonym: "MOO activity" EXACT [EC:1.13.99.1] +synonym: "myo-inositol oxygenase activity" EXACT [] +synonym: "myo-inositol:oxygen oxidoreductase activity" EXACT [EC:1.13.99.1] +xref: EC:1.13.99.1 +xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0050114 +name: myo-inosose-2 dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O." [EC:4.2.1.44, MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN] +synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" EXACT [EC:4.2.1.44] +synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" EXACT [EC:4.2.1.44] +synonym: "inosose 2,3-dehydratase activity" EXACT [EC:4.2.1.44] +synonym: "ketoinositol dehydratase activity" EXACT [EC:4.2.1.44] +xref: EC:4.2.1.44 +xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050115 +name: myosin-light-chain-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN] +synonym: "[Myosin light-chain]-phosphatase activity" EXACT [] +synonym: "myosin light chain kinase phosphatase activity" EXACT [EC:3.1.3.53] +synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53] +synonym: "myosin-light-chain phosphatase activity" EXACT [EC:3.1.3.53] +synonym: "myosin-light-chain-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.53] +synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53] +xref: EC:3.1.3.53 +xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050116 +name: N,N-dimethylformamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate." [EC:3.5.1.56, MetaCyc:N\,N-DIMETHYLFORMAMIDASE-RXN] +synonym: "dimethylformamidase activity" EXACT [EC:3.5.1.56] +synonym: "DMFase activity" EXACT [EC:3.5.1.56] +synonym: "N,N-dimethylformamide amidohydrolase activity" EXACT [EC:3.5.1.56] +xref: EC:3.5.1.56 +xref: MetaCyc:N\,N-DIMETHYLFORMAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050117 +name: N-acetyl-beta-alanine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-alanine + H2O = acetate + beta-alanine." [EC:3.5.1.21, MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN] +synonym: "N-acetyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.21] +xref: EC:3.5.1.21 +xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0050118 +name: N-acetyldiaminopimelate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-LL2,6-diaminoheptanedioate + H2O = acetate + LL2,6-diaminoheptanedioate." [EC:3.5.1.47, MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN] +subset: gosubset_prok +synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] +synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.47] +synonym: "N-acetyl-LL-diaminopimelate deacylase activity" EXACT [EC:3.5.1.47] +synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47] +xref: EC:3.5.1.47 +xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0050119 +name: N-acetylglucosamine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate." [EC:3.5.1.33, MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN] +synonym: "acetylaminodeoxyglucose acetylhydrolase activity" EXACT [EC:3.5.1.33] +synonym: "N-acetyl-D-glucosamine amidohydrolase activity" EXACT [EC:3.5.1.33] +synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" EXACT [EC:3.5.1.33] +xref: EC:3.5.1.33 +xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0050120 +name: N-acetylhexosamine 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + N-acetyl-D-glucosamine = NADH + N-acetyl-D-glucosaminate." [EC:1.1.1.240, MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN] +synonym: "N-acetyl-D-hexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] +synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.240] +synonym: "N-acetylhexosamine dehydrogenase activity" EXACT [EC:1.1.1.240] +xref: EC:1.1.1.240 +xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050121 +name: N-acylglucosamine 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN] +subset: gosubset_prok +synonym: "acylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] +synonym: "GlcNAc 2-epimerase activity" EXACT [EC:5.1.3.8] +synonym: "N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] +synonym: "N-acetylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] +synonym: "N-acyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8] +xref: EC:5.1.3.8 +xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050122 +name: N-acylhexosamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + O2 + N-acetyl-D-glucosamine = H2O2 + N-acetyl-D-glucosaminate." [EC:1.1.3.29, MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN] +synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] +synonym: "N-acyl-D-hexosamine oxidase activity" EXACT [EC:1.1.3.29] +synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29] +xref: EC:1.1.3.29 +xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050123 +name: N-acylmannosamine 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + NADH." [EC:1.1.1.233, MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "N-acetyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] +synonym: "N-acyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] +synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.233] +synonym: "N-acylmannosamine dehydrogenase activity" EXACT [EC:1.1.1.233] +xref: EC:1.1.1.233 +xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050124 +name: N-acylneuraminate-9-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "acylneuraminate 9-phosphatase activity" EXACT [EC:3.1.3.29] +synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.29] +synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" EXACT [EC:3.1.3.29] +synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" EXACT [EC:3.1.3.29] +xref: EC:3.1.3.29 +xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050125 +name: N-benzyloxycarbonylglycine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O = benzyl alcohol + CO2 + glycine." [EC:3.5.1.58, MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN] +synonym: "benzyloxycarbonylglycine hydrolase activity" EXACT [EC:3.5.1.58] +synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" EXACT [EC:3.5.1.58] +synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" EXACT [EC:3.5.1.58] +synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58] +synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" EXACT [EC:3.5.1.58] +xref: EC:3.5.1.58 +xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050126 +name: N-carbamoylputrescine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine." [EC:3.5.1.53, MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN] +synonym: "carbamoylputrescine hydrolase activity" EXACT [EC:3.5.1.53] +synonym: "N-carbamoylputrescine amidohydrolase activity" EXACT [EC:3.5.1.53] +synonym: "NCP" RELATED [EC:3.5.1.53] +xref: EC:3.5.1.53 +xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050127 +name: N-carbamoylsarcosine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3." [EC:3.5.1.59, MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN] +subset: gosubset_prok +synonym: "carbamoylsarcosine amidase activity" EXACT [EC:3.5.1.59] +synonym: "CSHase activity" EXACT [EC:3.5.1.59] +synonym: "N-carbamoylsarcosine amidohydrolase activity" EXACT [EC:3.5.1.59] +xref: EC:3.5.1.59 +xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050128 +name: N-feruloylglycine deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine." [EC:3.5.1.71, MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN] +synonym: "N-feruloylglycine amidohydrolase activity" EXACT [EC:3.5.1.71] +synonym: "N-feruloylglycine hydrolase activity" EXACT [EC:3.5.1.71] +xref: EC:3.5.1.71 +xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050129 +name: N-formylglutamate deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-glutamate + H2O = formate + L-glutamate." [EC:3.5.1.68, MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN] +subset: gosubset_prok +synonym: "beta-citryl-L-glutamate amidase activity" EXACT [EC:3.5.1.68] +synonym: "beta-citryl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] +synonym: "beta-citryl-L-glutamate hydrolase activity" EXACT [EC:3.5.1.68] +synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68] +synonym: "beta-citrylglutamate amidase activity" EXACT [EC:3.5.1.68] +synonym: "formylglutamate deformylase activity" EXACT [EC:3.5.1.68] +synonym: "N-formyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68] +synonym: "N-formylglutamate hydrolase activity" EXACT [EC:3.5.1.68] +xref: EC:3.5.1.68 +xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050130 +name: N-methyl-2-oxoglutaramate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine." [EC:3.5.1.36, MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN] +synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" EXACT [EC:3.5.1.36] +synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" EXACT [EC:3.5.1.36] +xref: EC:3.5.1.36 +xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050131 +name: N-methyl-L-amino-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN] +synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.2] +synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2] +xref: EC:1.5.3.2 +xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0050132 +name: N-methylalanine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = pyruvate + methylamine + NADPH." [EC:1.4.1.17, MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN] +synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" EXACT [EC:1.4.1.17] +xref: EC:1.4.1.17 +xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050133 +name: N6-hydroxylysine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine." [EC:2.3.1.102, MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] +synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102] +synonym: "N(6)-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] +synonym: "N6-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102] +synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" EXACT [EC:2.3.1.102] +xref: EC:2.3.1.102 +xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050134 +name: N6-methyl-lysine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N6-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2." [EC:1.5.3.4, MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN] +synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] +synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.4] +synonym: "epsilon-alkyllysinase activity" EXACT [EC:1.5.3.4] +synonym: "epsilon-N-methyllysine demethylase activity" EXACT [EC:1.5.3.4] +synonym: "N(6)-methyllysine oxidase activity" EXACT [EC:1.5.3.4] +synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4] +synonym: "N6-methyllysine oxidase activity" EXACT [EC:1.5.3.4] +xref: EC:1.5.3.4 +xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0050135 +name: NAD(P)+ nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + H2O = ADPribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NAD(P)(+)-NUCLEOSIDASE-RXN] +synonym: "NAD(P) nucleosidase activity" EXACT [] +synonym: "NAD(P)(+) nucleosidase activity" EXACT [] +synonym: "NAD(P)+ glycohydrolase activity" EXACT [EC:3.2.2.6] +synonym: "NAD(P)ase activity" EXACT [EC:3.2.2.6] +synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" EXACT [EC:3.2.2.6] +synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" EXACT [EC:3.2.2.6] +synonym: "triphosphopyridine nucleotidase activity" EXACT [EC:3.2.2.6] +xref: EC:3.2.2.6 +xref: MetaCyc:NAD(P)(+)-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0050136 +name: NADH dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-(QUINONE)-RXN] +subset: gosubset_prok +synonym: "D-diaphorase activity" EXACT [EC:1.6.99.5] +synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.99.5] +synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.99.5] +synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.99.5] +synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5] +xref: EC:1.6.99.5 +xref: MetaCyc:NADH-DEHYDROGENASE-(QUINONE)-RXN +is_a: GO:0003954 ! NADH dehydrogenase activity +is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor + +[Term] +id: GO:0050137 +name: NADPH peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H2O2 = NADP+ + 2 H2O." [EC:1.11.1.2, MetaCyc:NADPH-PEROXIDASE-RXN] +synonym: "NADP peroxidase activity" EXACT [EC:1.11.1.2] +synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.2] +synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" EXACT [EC:1.11.1.2] +synonym: "TPN peroxidase activity" EXACT [EC:1.11.1.2] +synonym: "TPNH peroxidase activity" EXACT [EC:1.11.1.2] +synonym: "triphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.2] +xref: EC:1.11.1.2 +xref: MetaCyc:NADPH-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0050138 +name: nicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH." [EC:1.17.1.5, MetaCyc:NICOTINATE-DEHYDROGENASE-RXN] +synonym: "nicotinate hydroxylase activity" EXACT [EC:1.17.1.5] +synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" EXACT [EC:1.17.1.5] +synonym: "nicotinic acid hydroxylase activity" EXACT [EC:1.17.1.5] +xref: EC:1.17.1.5 +xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0050139 +name: nicotinate glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + nicotinate = UDP + N-glucosylnicotinate." [EC:2.4.1.196, MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] +synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" EXACT [EC:2.4.1.196] +synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] +synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196] +xref: EC:2.4.1.196 +xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050140 +name: nitrate reductase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: ferrocytochrome + NO3- (nitrate) = ferricytochrome + NO2- (nitrite)." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-(CYTOCHROME)-RXN] +synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1] +synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1] +xref: EC:1.9.6.1 +xref: MetaCyc:NITRATE-REDUCTASE-(CYTOCHROME)-RXN +is_a: GO:0016677 ! oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor + +[Term] +id: GO:0050141 +name: nitroethane oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + NO2(-) (nitrite) + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN] +synonym: "NAO activity" EXACT [EC:1.7.3.1] +synonym: "nitroalkane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] +synonym: "Nitroethane oxidase activity" EXACT [EC:1.7.3.1] +synonym: "nitroethane reductase activity" EXACT [EC:1.7.3.1] +synonym: "nitroethane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1] +xref: EC:1.7.3.1 +xref: MetaCyc:NITROETHANE-OXIDASE-RXN +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0050142 +name: nitrogenase (flavodoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-(FLAVODOXIN)-RXN] +subset: gosubset_prok +synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1] +xref: EC:1.19.6.1 +xref: MetaCyc:NITROGENASE-(FLAVODOXIN)-RXN +is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor + +[Term] +id: GO:0050143 +name: nocardicin-A epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, MetaCyc:NOCARDICIN-A-EPIMERASE-RXN] +synonym: "isonocardicin A epimerase activity" EXACT [EC:5.1.1.14] +xref: EC:5.1.1.14 +xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0050144 +name: nucleoside deoxyribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "deoxyribose transferase activity" EXACT [EC:2.4.2.6] +synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6] +synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6] +synonym: "nucleoside trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] +synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.6] +synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" EXACT [EC:2.4.2.6] +synonym: "trans-deoxyribosylase activity" EXACT [EC:2.4.2.6] +synonym: "trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6] +synonym: "trans-N-glycosidase activity" EXACT [EC:2.4.2.6] +xref: EC:2.4.2.6 +xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0050145 +name: nucleoside phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate." [EC:2.7.4.4, MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN] +synonym: "ATP:nucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.4] +synonym: "NMP-kinase activity" EXACT [EC:2.7.4.4] +synonym: "nucleoside-phosphate kinase activity" EXACT [] +xref: EC:2.7.4.4 +xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0050146 +name: nucleoside phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN] +synonym: "nonspecific nucleoside phosphotransferase activity" EXACT [EC:2.7.1.77] +synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] +synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] +synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77] +xref: EC:2.7.1.77 +xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0050147 +name: nucleoside ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN] +synonym: "nucleoside N-ribosyltransferase activity" EXACT [EC:2.4.2.5] +synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" EXACT [EC:2.4.2.5] +xref: EC:2.4.2.5 +xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0050148 +name: nucleotide diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN] +synonym: "ATP nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] +synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.4] +synonym: "ATP:nucleotide pyrophosphotransferase activity" EXACT [EC:2.7.6.4] +synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4] +synonym: "nucleotide pyrophosphokinase activity" EXACT [] +xref: EC:2.7.6.4 +xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0050149 +name: o-aminophenol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN] +synonym: "2-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] +synonym: "2-aminophenol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.4] +synonym: "GriF" RELATED [EC:1.10.3.4] +synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4] +synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4] +xref: EC:1.10.3.4 +xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0050150 +name: o-pyrocatechuate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate = catechol + CO2." [EC:4.1.1.46, MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN] +synonym: "2,3-DHBA decarboxylase activity" EXACT [EC:4.1.1.46] +synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.46] +synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.46] +synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" EXACT [EC:4.1.1.46] +xref: EC:4.1.1.46 +xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050151 +name: oleate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-10-hydroxystearate = oleate + H2O." [EC:4.2.1.53, MetaCyc:OLEATE-HYDRATASE-RXN] +synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" EXACT [EC:4.2.1.53] +synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" EXACT [EC:4.2.1.53] +xref: EC:4.2.1.53 +xref: MetaCyc:OLEATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050152 +name: omega-amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN] +synonym: "alpha-keto acid-omega-amidase activity" EXACT [EC:3.5.1.3] +synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3] +synonym: "w-amidase activity" EXACT [] +xref: EC:3.5.1.3 +xref: MetaCyc:OMEGA-AMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050153 +name: omega-hydroxydecanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH." [EC:1.1.1.66, MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN] +synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" EXACT [EC:1.1.1.66] +synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT [] +xref: EC:1.1.1.66 +xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050154 +name: opheline kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = ADP + N'-phosphoguanidinoethyl methylphosphate." [EC:2.7.3.7, MetaCyc:OPHELINE-KINASE-RXN] +synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" EXACT [EC:2.7.3.7] +xref: EC:2.7.3.7 +xref: MetaCyc:OPHELINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0050155 +name: ornithine(lysine) transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [EC:2.6.1.68, MetaCyc:ORNITHINE(LYSINE)-AMINOTRANSFERASE-RXN] +synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68] +synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68] +synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.68] +synonym: "ornithine(lysine) aminotransferase activity" EXACT [] +xref: EC:2.6.1.68 +xref: MetaCyc:ORNITHINE(LYSINE)-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050156 +name: ornithine N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 benzoyl-CoA + L-ornithine = 2 CoA + N2,N5-dibenzoyl-L-ornithine." [EC:2.3.1.127, MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN] +synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" EXACT [EC:2.3.1.127] +synonym: "ornithine N-acyltransferase activity" EXACT [EC:2.3.1.127] +xref: EC:2.3.1.127 +xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050157 +name: ornithine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN] +subset: gosubset_prok +xref: EC:5.1.1.12 +xref: MetaCyc:ORNITHINE-RACEMASE-RXN +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0050158 +name: orotate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH." [EC:1.3.1.15, MetaCyc:OROTATE-REDUCTASE-(NADPH)-RXN] +synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.15] +synonym: "dihydro-orotic dehydrogenase activity" EXACT [EC:1.3.1.15] +synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" EXACT [EC:1.3.1.15] +synonym: "orotate reductase activity" EXACT [EC:1.3.1.15] +xref: EC:1.3.1.15 +xref: MetaCyc:OROTATE-REDUCTASE-(NADPH)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050159 +name: orsellinate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-6-methylbenzoate = orcinol + CO2." [EC:4.1.1.58, MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN] +synonym: "orsellinate carboxy-lyase (orcinol-forming)" EXACT [EC:4.1.1.58] +synonym: "orsellinate carboxy-lyase activity" EXACT [EC:4.1.1.58] +xref: EC:4.1.1.58 +xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050160 +name: orsellinate-depside hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: orsellinate depside + H2O = 2 orsellinate." [EC:3.1.1.40, MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN] +synonym: "lecanorate hydrolase activity" EXACT [EC:3.1.1.40] +xref: EC:3.1.1.40 +xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050161 +name: oxalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + oxalate = succinate + oxalyl-CoA." [EC:2.8.3.2, MetaCyc:OXALATE-COA-TRANSFERASE-RXN] +synonym: "oxalate coenzyme A-transferase activity" EXACT [EC:2.8.3.2] +synonym: "succinyl-beta-ketoacyl-CoA transferase activity" EXACT [EC:2.8.3.2] +synonym: "succinyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.2] +xref: EC:2.8.3.2 +xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0050162 +name: oxalate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxalate + O2 = 2 CO2 + H2O2." [EC:1.2.3.4, MetaCyc:OXALATE-OXIDASE-RXN] +synonym: "aero-oxalo dehydrogenase activity" EXACT [EC:1.2.3.4] +synonym: "oxalate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.4] +synonym: "oxalic acid oxidase activity" EXACT [EC:1.2.3.4] +xref: EC:1.2.3.4 +xref: MetaCyc:OXALATE-OXIDASE-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0050163 +name: oxaloacetate tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-oxaloacetate = enol-oxaloacetate." [EC:5.3.2.2, MetaCyc:OXALOACETATE-TAUTOMERASE-RXN] +synonym: "oxalacetic keto-enol isomerase activity" EXACT [EC:5.3.2.2] +synonym: "oxaloacetate keto-enol tautomerase activity" EXACT [EC:5.3.2.2] +synonym: "oxaloacetate keto-enol-isomerase activity" EXACT [EC:5.3.2.2] +xref: EC:5.3.2.2 +xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0050164 +name: oxoglutarate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH." [EC:1.2.1.52, MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN] +synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.1.52] +xref: EC:1.2.1.52 +xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0050165 +name: pantetheine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN] +synonym: "ATP:pantetheine 4'-phosphotransferase activity" EXACT [EC:2.7.1.34] +synonym: "pantetheine kinase (phosphorylating)" EXACT [EC:2.7.1.34] +xref: EC:2.7.1.34 +xref: MetaCyc:PANTETHEINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050166 +name: pantoate 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + NADH." [EC:1.1.1.106, MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN] +synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] +synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106] +synonym: "panthothenase activity" EXACT [EC:1.1.1.106] +synonym: "pantoate dehydrogenase activity" EXACT [EC:1.1.1.106] +xref: EC:1.1.1.106 +xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050167 +name: pantothenoylcysteine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2." [EC:4.1.1.30, MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN] +synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] +synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" EXACT [EC:4.1.1.30] +synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30] +synonym: "pantothenylcysteine decarboxylase activity" EXACT [EC:4.1.1.30] +xref: EC:4.1.1.30 +xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050168 +name: pentanamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pentanamide + H2O = pentanoate + NH3." [EC:3.5.1.50, MetaCyc:PENTANAMIDASE-RXN] +synonym: "pentanamide amidohydrolase activity" EXACT [EC:3.5.1.50] +synonym: "valeramidase activity" EXACT [EC:3.5.1.50] +xref: EC:3.5.1.50 +xref: MetaCyc:PENTANAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050169 +name: peptide-tryptophan 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-2\,3-DIOXYGENASE-RXN] +synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.26] +synonym: "peptidyltryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.26] +synonym: "pyrrolooxygenase activity" EXACT [EC:1.13.11.26] +synonym: "tryptophan pyrrolooxygenase activity" EXACT [EC:1.13.11.26] +xref: EC:1.13.11.26 +xref: MetaCyc:PEPTIDE-TRYPTOPHAN-2\,3-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050170 +name: peptidyl-glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN] +synonym: "peptideglutaminase activity" EXACT [EC:3.5.1.43] +synonym: "peptidoglutaminase activity" EXACT [EC:3.5.1.43] +synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43] +synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43] +xref: EC:3.5.1.43 +xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050171 +name: phenol beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "phenol b-glucosyltransferase activity" EXACT [] +synonym: "phenol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] +synonym: "UDP glucosyltransferase activity" EXACT [EC:2.4.1.35] +synonym: "UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.35] +synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] +synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35] +synonym: "UDPglucosyltransferase activity" EXACT [EC:2.4.1.35] +synonym: "uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.35] +xref: EC:2.4.1.35 +xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050172 +name: phenylalanine 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O." [EC:1.13.12.9, MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN] +subset: gosubset_prok +synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" EXACT [EC:1.13.12.9] +synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" EXACT [EC:1.13.12.9] +synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.9] +synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" EXACT [EC:1.13.12.9] +synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" EXACT [EC:1.13.12.9] +xref: EC:1.13.12.9 +xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050173 +name: phenylalanine adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-phenylalanine = diphosphate + N-adenylyl-L-phenylalanine." [EC:2.7.7.54, MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN] +synonym: "ATP:L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] +synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT [] +synonym: "L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54] +xref: EC:2.7.7.54 +xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0050174 +name: phenylalanine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN] +synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53] +synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53] +synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53] +synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53] +xref: EC:4.1.1.53 +xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050175 +name: phenylalanine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "L-phenylalanine dehydrogenase activity" EXACT [EC:1.4.1.20] +synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.20] +synonym: "PHD" RELATED [EC:1.4.1.20] +synonym: "PheDH activity" EXACT [EC:1.4.1.20] +xref: EC:1.4.1.20 +xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050176 +name: phenylalanine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine." [EC:2.3.1.53, MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.53] +synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" EXACT [EC:2.3.1.53] +xref: EC:2.3.1.53 +xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0050177 +name: phenylpyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN] +synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" EXACT [EC:4.1.1.43] +synonym: "phenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.43] +xref: EC:4.1.1.43 +xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050178 +name: phenylpyruvate tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN] +subset: gosubset_prok +synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1] +synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1] +synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1] +xref: EC:5.3.2.1 +xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0050179 +name: phenylserine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threo-3-phenylserine = glycine + benzaldehyde." [EC:4.1.2.26, MetaCyc:PHENYLSERINE-ALDOLASE-RXN] +synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.26] +synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" EXACT [EC:4.1.2.26] +xref: EC:4.1.2.26 +xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050180 +name: phloretin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phloretin + H2O = phloretate + phloroglucinol." [EC:3.7.1.4, MetaCyc:PHLORETIN-HYDROLASE-RXN] +synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" EXACT [EC:3.7.1.4] +synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4] +xref: EC:3.7.1.4 +xref: MetaCyc:PHLORETIN-HYDROLASE-RXN +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0050181 +name: phorbol-diester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate." [EC:3.1.1.51, MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN] +synonym: "12,13-diacylphorbate 12-acylhydrolase activity" EXACT [EC:3.1.1.51] +synonym: "diacylphorbate 12-hydrolase activity" EXACT [EC:3.1.1.51] +synonym: "PDEH" RELATED [EC:3.1.1.51] +synonym: "phorbol-12,13-diester 12-ester hydrolase activity" EXACT [EC:3.1.1.51] +xref: EC:3.1.1.51 +xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050182 +name: phosphate butyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + phosphate = CoA + butanoylphosphate." [EC:2.3.1.19, MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" EXACT [EC:2.3.1.19] +synonym: "phosphotransbutyrylase activity" EXACT [EC:2.3.1.19] +xref: EC:2.3.1.19 +xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050183 +name: phosphatidylcholine 12-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + NAD+ + H2O." [EC:1.14.13.26, MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN] +synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.26] +synonym: "oleate D12-hydroxylase activity" EXACT [] +synonym: "oleate Delta(12)-hydroxylase activity" EXACT [EC:1.14.13.26] +synonym: "oleate delta12-hydroxylase activity" EXACT [EC:1.14.13.26] +synonym: "oleate delta12-monooxygenase activity" EXACT [EC:1.14.13.26] +synonym: "ricinoleic acid synthase activity" EXACT [EC:1.14.13.26] +xref: EC:1.14.13.26 +xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050184 +name: phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH." [EC:1.3.1.35, MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN] +synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" EXACT [EC:1.3.1.35] +synonym: "linoleate synthase activity" EXACT [EC:1.3.1.35] +synonym: "oleate desaturase activity" EXACT [EC:1.3.1.35] +synonym: "oleoyl-CoA desaturase activity" EXACT [EC:1.3.1.35] +synonym: "oleoylphosphatidylcholine desaturase activity" EXACT [EC:1.3.1.35] +xref: EC:1.3.1.35 +xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050185 +name: phosphatidylinositol deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-D-myo-inositol + H2O = 1-acylglycerophosphoinositol + a carboxylate." [EC:3.1.1.52, MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN] +synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" EXACT [EC:3.1.1.52] +synonym: "phosphatidylinositol phospholipase A2 activity" EXACT [EC:3.1.1.52] +xref: EC:3.1.1.52 +xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050186 +name: phosphoadenylylsulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + SO4(2-) (sulfate)." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN] +synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.2] +synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" EXACT [EC:3.6.2.2] +synonym: "3-phosphoadenylyl sulfatase activity" EXACT [EC:3.6.2.2] +synonym: "PAPS sulfatase activity" EXACT [EC:3.6.2.2] +synonym: "phosphoadenylylsulphatase activity" EXACT [] +xref: EC:3.6.2.2 +xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN +is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides + +[Term] +id: GO:0050187 +name: phosphoamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate." [EC:3.9.1.1, MetaCyc:PHOSPHOAMIDASE-RXN] +synonym: "creatine phosphatase activity" EXACT [EC:3.9.1.1] +synonym: "phosphamide hydrolase activity" EXACT [EC:3.9.1.1] +xref: EC:3.9.1.1 +xref: MetaCyc:PHOSPHOAMIDASE-RXN +is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds + +[Term] +id: GO:0050188 +name: phosphoenolpyruvate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN] +subset: gosubset_prok +synonym: "PEP mutase activity" EXACT [EC:5.4.2.9] +synonym: "PEP phosphomutase activity" EXACT [EC:5.4.2.9] +synonym: "PEPPM" RELATED [EC:5.4.2.9] +synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" EXACT [EC:5.4.2.9] +synonym: "phosphoenolpyruvate phosphomutase activity" EXACT [EC:5.4.2.9] +synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" EXACT [EC:5.4.2.9] +xref: EC:5.4.2.9 +xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0050189 +name: phosphoenolpyruvate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + H2O = pyruvate + phosphate." [EC:3.1.3.60, MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN] +synonym: "PEP phosphatase activity" EXACT [EC:3.1.3.60] +synonym: "phosphoenolpyruvate phosphohydrolase activity" EXACT [EC:3.1.3.60] +xref: EC:3.1.3.60 +xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050190 +name: phosphoglucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate." [EC:2.7.1.10, MetaCyc:PHOSPHOGLUCOKINASE-RXN] +synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] +synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10] +synonym: "glucose-phosphate kinase activity" EXACT [EC:2.7.1.10] +synonym: "phosphoglucokinase (phosphorylating)" EXACT [EC:2.7.1.10] +xref: EC:2.7.1.10 +xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050191 +name: phosphoglycerate kinase (GTP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 3-phospho-D-glycerate = GDP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.10, MetaCyc:PHOSPHOGLYCERATE-KINASE-(GTP)-RXN] +synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.10] +xref: EC:2.7.2.10 +xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-(GTP)-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0050192 +name: phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate 2-phosphate + H2O = D-glycerate + phosphate." [EC:3.1.3.20, MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN] +synonym: "D-2-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.20] +synonym: "D-glycerate-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.20] +synonym: "glycerophosphate phosphatase activity" EXACT [EC:3.1.3.20] +xref: EC:3.1.3.20 +xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050193 +name: phosphoketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN] +subset: gosubset_prok +synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.9] +synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.9] +synonym: "xylulose-5-phosphate phosphoketolase activity" EXACT [EC:4.1.2.9] +xref: EC:4.1.2.9 +xref: MetaCyc:PHOSPHOKETOLASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050194 +name: phosphonoacetaldehyde hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphonoacetaldehyde + H2O = acetaldehyde + phosphate." [EC:3.11.1.1, MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN] +subset: gosubset_prok +synonym: "2-oxoethylphosphonate phosphonohydrolase activity" EXACT [EC:3.11.1.1] +synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] +synonym: "phosphonatase activity" EXACT [EC:3.11.1.1] +synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1] +xref: EC:3.11.1.1 +xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN +is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds + +[Term] +id: GO:0050195 +name: phosphoribokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = ADP + D-ribose 1,5-bisphosphate." [EC:2.7.1.18, MetaCyc:PHOSPHORIBOKINASE-RXN] +synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.18] +synonym: "phosphoribokinase (phosphorylating)" EXACT [EC:2.7.1.18] +xref: EC:2.7.1.18 +xref: MetaCyc:PHOSPHORIBOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050196 +name: [phosphorylase] phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN] +synonym: "glycogen phosphorylase phosphatase activity" EXACT [EC:3.1.3.17] +synonym: "phosphorylase a phosphatase activity" EXACT [EC:3.1.3.17] +synonym: "phosphorylase a phosphohydrolase activity" EXACT [EC:3.1.3.17] +synonym: "phosphorylase phosphatase activity" EXACT [] +synonym: "PR-enzyme" RELATED [EC:3.1.3.17] +synonym: "protein phosphatase C" RELATED [EC:3.1.3.17] +synonym: "type 1 protein phosphatase activity" EXACT [EC:3.1.3.17] +xref: EC:3.1.3.17 +xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050197 +name: phytanate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA." [EC:6.2.1.24, MetaCyc:PHYTANATE--COA-LIGASE-RXN] +subset: gosubset_prok +synonym: "phytanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.24] +synonym: "phytanoyl-CoA ligase activity" EXACT [EC:6.2.1.24] +xref: EC:6.2.1.24 +xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050198 +name: pinosylvin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2." [EC:2.3.1.146, MetaCyc:PINOSYLVIN-SYNTHASE-RXN] +synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.146] +synonym: "pine stilbene synthase activity" EXACT [EC:2.3.1.146] +synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146] +xref: EC:2.3.1.146 +xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050199 +name: piperidine N-piperoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine." [EC:2.3.1.145, MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN] +synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] +synonym: "piperidine piperoyltransferase activity" EXACT [EC:2.3.1.145] +synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145] +xref: EC:2.3.1.145 +xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050200 +name: plasmalogen synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN] +synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.25] +synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" EXACT [EC:2.3.1.25] +synonym: "lysoplasmenylcholine acyltransferase activity" EXACT [EC:2.3.1.25] +synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.25] +xref: EC:2.3.1.25 +xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050201 +name: fucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 6-deoxy-L-galactose = ADP + 6-deoxy-L-galactose 1-phosphate." [EC:2.7.1.52, MetaCyc:FUCOKINASE-RXN] +synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] +synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" EXACT [EC:2.7.1.52] +synonym: "fucokinase (phosphorylating) activity" EXACT [EC:2.7.1.52] +synonym: "fucose kinase activity" EXACT [EC:2.7.1.52] +synonym: "L-fucokinase activity" EXACT [EC:2.7.1.52] +synonym: "L-fucose kinase activity" EXACT [EC:2.7.1.52] +xref: EC:2.7.1.52 +xref: MetaCyc:FUCOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050202 +name: octopamine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3." [EC:4.2.1.87, MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN] +synonym: "octopamine hydro-lyase (deaminating)" EXACT [EC:4.2.1.87] +synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87] +synonym: "octopamine hydrolyase activity" EXACT [EC:4.2.1.87] +xref: EC:4.2.1.87 +xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050203 +name: oxalate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + oxalate + CoA = AMP + diphosphate + oxalyl-CoA." [EC:6.2.1.8, MetaCyc:OXALATE--COA-LIGASE-RXN] +synonym: "oxalate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.8] +synonym: "oxalyl coenzyme A synthetase activity" EXACT [EC:6.2.1.8] +synonym: "oxalyl-CoA synthetase activity" EXACT [EC:6.2.1.8] +xref: EC:6.2.1.8 +xref: MetaCyc:OXALATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050204 +name: oxalomalate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxalomalate = oxaloacetate + glyoxylate." [EC:4.1.3.13, MetaCyc:OXALOMALATE-LYASE-RXN] +synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" EXACT [EC:4.1.3.13] +synonym: "3-oxalomalate glyoxylate-lyase activity" EXACT [EC:4.1.3.13] +xref: EC:4.1.3.13 +xref: MetaCyc:OXALOMALATE-LYASE-RXN +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0050205 +name: oxamate carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = phosphate + oxalureate." [EC:2.1.3.5, MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN] +synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" EXACT [EC:2.1.3.5] +synonym: "oxamic transcarbamylase activity" EXACT [EC:2.1.3.5] +xref: EC:2.1.3.5 +xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0050206 +name: oximinotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate oxime + acetone = pyruvate + acetone oxime." [EC:2.6.3.1, MetaCyc:OXIMINOTRANSFERASE-RXN] +synonym: "oximase activity" EXACT [EC:2.6.3.1] +synonym: "pyruvate-acetone oximinotransferase activity" EXACT [EC:2.6.3.1] +synonym: "pyruvate-oxime:acetone oximinotransferase activity" EXACT [EC:2.6.3.1] +synonym: "transoximase activity" EXACT [EC:2.6.3.1] +synonym: "transoximinase activity" EXACT [EC:2.6.3.1] +xref: EC:2.6.3.1 +xref: MetaCyc:OXIMINOTRANSFERASE-RXN +is_a: GO:0016770 ! oximinotransaminase activity + +[Term] +id: GO:0050207 +name: plasmanylethanolamine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN] +synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] +synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19] +synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" EXACT [EC:1.14.99.19] +synonym: "alkylacylglycerophosphoethanolamine desaturase activity" EXACT [EC:1.14.99.19] +synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" EXACT [EC:1.14.99.19] +synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.19] +synonym: "plasmenylethanolamine desaturase activity" EXACT [] +xref: EC:1.14.99.19 +xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050208 +name: polysialic-acid O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136] +synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136] +synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136] +synonym: "LRAT" RELATED [EC:2.3.1.136] +synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136] +xref: EC:2.3.1.136 +xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050209 +name: polyvinyl-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN] +synonym: "dehydrogenase, polyvinyl alcohol" EXACT [EC:1.1.3.30] +synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30] +synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30] +xref: EC:1.1.3.30 +xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050210 +name: prenyl-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN] +synonym: "prenol pyrophosphatase activity" EXACT [EC:3.1.7.1] +synonym: "prenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.1] +synonym: "prenyl-pyrophosphatase activity" EXACT [] +synonym: "prenylphosphatase activity" EXACT [EC:3.1.7.1] +xref: EC:3.1.7.1 +xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0050211 +name: procollagen galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN] +synonym: "collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "collagen hydroxylysyl galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "hydroxylysine galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "UDP galactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50] +synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50] +xref: EC:2.4.1.50 +xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0050212 +name: progesterone 11-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: progesterone + donor-H2 + O2 = 11-alpha-hydroxyprogesterone + acceptor + H2O." [EC:1.14.99.14, MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN] +synonym: "progesterone 11-alpha-hydroxylase activity" EXACT [EC:1.14.99.14] +synonym: "progesterone 11a-monooxygenase activity" EXACT [] +synonym: "progesterone 11alpha-hydroxylase activity" EXACT [EC:1.14.99.14] +synonym: "progesterone 11alpha-monooxygenase activity" EXACT [EC:1.14.99.14] +synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" EXACT [EC:1.14.99.14] +xref: EC:1.14.99.14 +xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050213 +name: progesterone 5-alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN] +synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.30] +synonym: "delta4-steroid 5alpha-reductase (progesterone)" EXACT [EC:1.3.1.30] +synonym: "progesterone 5a-reductase activity" EXACT [] +synonym: "progesterone 5alpha-reductase activity" EXACT [EC:1.3.1.30] +synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30] +xref: EC:1.3.1.30 +xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050214 +name: progesterone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: progesterone + donor-H2 + O2 = testosterone acetate + acceptor + H2O." [EC:1.14.99.4, MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN] +synonym: "progesterone hydroxylase activity" EXACT [EC:1.14.99.4] +synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.4] +xref: EC:1.14.99.4 +xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050215 +name: propanediol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,2-diol = propanal + H2O." [EC:4.2.1.28, MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN] +subset: gosubset_prok +synonym: "1,2-propanediol dehydratase activity" EXACT [EC:4.2.1.28] +synonym: "adenosylcobalamin-dependent diol dehydratase activity" EXACT [EC:4.2.1.28] +synonym: "coenzyme B12-dependent diol dehydrase activity" EXACT [EC:4.2.1.28] +synonym: "diol dehydrase activity" EXACT [EC:4.2.1.28] +synonym: "diol dehydratase activity" EXACT [EC:4.2.1.28] +synonym: "dioldehydratase activity" EXACT [EC:4.2.1.28] +synonym: "DL-1,2-propanediol hydro-lyase activity" EXACT [EC:4.2.1.28] +synonym: "meso-2,3-butanediol dehydrase activity" EXACT [EC:4.2.1.28] +synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" EXACT [EC:4.2.1.28] +synonym: "propane-1,2-diol hydro-lyase activity" EXACT [EC:4.2.1.28] +synonym: "propanediol dehydrase activity" EXACT [EC:4.2.1.28] +xref: EC:4.2.1.28 +xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050216 +name: propanediol-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH." [EC:1.1.1.7, MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN] +xref: EC:1.1.1.7 +xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050217 +name: propioin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone." [EC:4.1.2.35, MetaCyc:PROPIOIN-SYNTHASE-RXN] +synonym: "4-hydroxy-3-hexanone aldolase activity" EXACT [EC:4.1.2.35] +synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" EXACT [EC:4.1.2.35] +synonym: "4-hydroxy-3-hexanone propanal-lyase activity" EXACT [EC:4.1.2.35] +xref: EC:4.1.2.35 +xref: MetaCyc:PROPIOIN-SYNTHASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050218 +name: propionate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN] +subset: gosubset_prok +synonym: "propanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.17] +synonym: "propionyl-CoA synthetase activity" EXACT [EC:6.2.1.17] +xref: EC:6.2.1.17 +xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050219 +name: prostaglandin-A1 delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate." [EC:5.3.3.9, MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN] +synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" EXACT [EC:5.3.3.9] +synonym: "prostaglandin A isomerase activity" EXACT [EC:5.3.3.9] +synonym: "prostaglandin-A1 D-isomerase activity" EXACT [] +xref: EC:5.3.3.9 +xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050220 +name: prostaglandin-E synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate." [EC:5.3.99.3, MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [EC:5.3.99.3] +synonym: "endoperoxide isomerase activity" EXACT [EC:5.3.99.3] +synonym: "PGE isomerase activity" EXACT [EC:5.3.99.3] +synonym: "PGE2 isomerase activity" EXACT [EC:5.3.99.3] +synonym: "PGH-PGE isomerase activity" EXACT [EC:5.3.99.3] +synonym: "prostaglandin endoperoxide E isomerase activity" EXACT [EC:5.3.99.3] +synonym: "prostaglandin endoperoxide E2 isomerase activity" EXACT [EC:5.3.99.3] +synonym: "prostaglandin H-E isomerase activity" EXACT [EC:5.3.99.3] +synonym: "prostaglandin R-prostaglandin E isomerase activity" EXACT [EC:5.3.99.3] +synonym: "Prostaglandin-H(2) E-isomerase activity" EXACT [EC:5.3.99.3] +synonym: "prostaglandin-H2 E-isomerase activity" EXACT [EC:5.3.99.3] +xref: EC:5.3.99.3 +xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0050221 +name: prostaglandin-E2 9-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" EXACT [EC:1.1.1.189] +synonym: "9-keto-prostaglandin E(2) reductase activity" EXACT [EC:1.1.1.189] +synonym: "9-keto-prostaglandin E2 reductase activity" EXACT [EC:1.1.1.189] +synonym: "9-ketoprostaglandin reductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE(2) 9-ketoreductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE-9-ketoreductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE2 9-ketoreductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE2 9-oxoreductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE2-9-ketoreductase activity" EXACT [EC:1.1.1.189] +synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189] +synonym: "prostaglandin E 9-ketoreductase activity" EXACT [EC:1.1.1.189] +synonym: "prostaglandin E2-9-oxoreductase activity" EXACT [EC:1.1.1.189] +synonym: "prostaglandin-E(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189] +synonym: "prostaglandin-E2 9-oxoreductase activity" EXACT [EC:1.1.1.189] +synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" EXACT [EC:1.1.1.189] +xref: EC:1.1.1.189 +xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050223 +name: protocatechuate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxybenzoate = catechol + CO2." [EC:4.1.1.63, MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN] +synonym: "3,4-dihydrobenzoate decarboxylase activity" EXACT [EC:4.1.1.63] +synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.63] +synonym: "3,4-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.63] +synonym: "protocatechuate carboxy-lyase activity" EXACT [EC:4.1.1.63] +xref: EC:4.1.1.63 +xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050224 +name: prunasin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile." [EC:3.2.1.118, MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN] +synonym: "prunasin b-glucosidase activity" EXACT [] +synonym: "prunasin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.118] +synonym: "prunasin hydrolase activity" EXACT [EC:3.2.1.118] +xref: EC:3.2.1.118 +xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050225 +name: pseudouridine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pseudouridine = ADP + pseudouridine 5'-phosphate." [EC:2.7.1.83, MetaCyc:PSEUDOURIDINE-KINASE-RXN] +synonym: "ATP:pseudouridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.83] +synonym: "pseudouridine kinase (phosphorylating)" EXACT [EC:2.7.1.83] +xref: EC:2.7.1.83 +xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050226 +name: psychosine sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] +synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" EXACT [EC:2.8.2.13] +synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13] +synonym: "psychosine sulphotransferase activity" EXACT [] +xref: EC:2.8.2.13 +xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050227 +name: pteridine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN] +synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1] +xref: EC:1.17.3.1 +xref: MetaCyc:PTERIDINE-OXIDASE-RXN +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0050228 +name: pterin deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN] +synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" EXACT [EC:3.5.4.11] +synonym: "acrasinase activity" EXACT [EC:3.5.4.11] +xref: EC:3.5.4.11 +xref: MetaCyc:PTERIN-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050229 +name: pterocarpin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN] +synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.246] +synonym: "pterocarpan synthase activity" EXACT [EC:1.1.1.246] +xref: EC:1.1.1.246 +xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050230 +name: purine imidazole-ring cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN] +synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" EXACT [EC:4.3.2.4] +synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] +synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4] +xref: EC:4.3.2.4 +xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0050231 +name: putrescine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine." [EC:2.1.3.6, MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" EXACT [EC:2.1.3.6] +synonym: "PTCase activity" EXACT [EC:2.1.3.6] +synonym: "putrescine synthase activity" EXACT [EC:2.1.3.6] +synonym: "putrescine transcarbamylase activity" EXACT [EC:2.1.3.6] +xref: EC:2.1.3.6 +xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0050232 +name: putrescine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] +subset: gosubset_prok +synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10] +xref: EC:1.4.3.10 +xref: MetaCyc:PUTRESCINE-OXIDASE-RXN +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0050233 +name: pyranose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2." [EC:1.1.3.10, MetaCyc:PYRANOSE-OXIDASE-RXN] +synonym: "glucose 2-oxidase activity" EXACT [EC:1.1.3.10] +synonym: "pyranose-2-oxidase activity" EXACT [EC:1.1.3.10] +synonym: "pyranose:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.10] +xref: EC:1.1.3.10 +xref: MetaCyc:PYRANOSE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050234 +name: pyrazolylalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O." [EC:4.2.1.50, MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN] +synonym: "beta-pyrazolylalaninase activity" EXACT [EC:4.2.1.50] +synonym: "L-serine hydro-lyase (adding pyrazole)" EXACT [EC:4.2.1.50] +synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50] +xref: EC:4.2.1.50 +xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050235 +name: pyridoxal 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxal + NAD+ = 4-pyridoxolactone + NADH." [EC:1.1.1.107, MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN] +synonym: "pyridoxal dehydrogenase activity" EXACT [EC:1.1.1.107] +synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.107] +xref: EC:1.1.1.107 +xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050236 +name: pyridoxine 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + NADP+ = pyridoxal + NADPH." [EC:1.1.1.65, MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN] +synonym: "PL reductase activity" EXACT [EC:1.1.1.65] +synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65] +synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65] +synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65] +synonym: "pyridoxine:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.65] +synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65] +xref: EC:1.1.1.65 +xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN +is_a: GO:0004033 ! aldo-keto reductase activity + +[Term] +id: GO:0050237 +name: pyridoxine 4-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN] +synonym: "pyridoxin 4-oxidase activity" EXACT [EC:1.1.3.12] +synonym: "pyridoxine:oxygen 4-oxidoreductase activity" EXACT [EC:1.1.3.12] +synonym: "pyridoxol 4-oxidase activity" EXACT [EC:1.1.3.12] +xref: EC:1.1.3.12 +xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050238 +name: pyridoxine 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN] +synonym: "pyridoxal-5-dehydrogenase activity" EXACT [EC:1.1.99.9] +synonym: "pyridoxin 5-dehydrogenase activity" EXACT [EC:1.1.99.9] +synonym: "pyridoxine 5'-dehydrogenase activity" EXACT [EC:1.1.99.9] +synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.9] +synonym: "pyridoxine:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.9] +synonym: "pyridoxol 5-dehydrogenase activity" EXACT [EC:1.1.99.9] +xref: EC:1.1.99.9 +xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050239 +name: pyrithiamine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN] +synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" EXACT [EC:3.5.4.20] +xref: EC:3.5.4.20 +xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050240 +name: pyrogallol 1,2-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2,3-trihydroxybenzene + O2 = (Z)-5-oxohex-2-enedioate." [EC:1.13.11.35, MetaCyc:PYROGALLOL-1\,2-OXYGENASE-RXN] +synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.35] +synonym: "pyrogallol 1,2-dioxygenase activity" EXACT [EC:1.13.11.35] +xref: EC:1.13.11.35 +xref: MetaCyc:PYROGALLOL-1\,2-OXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050241 +name: pyrroline-2-carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN] +synonym: "delta1-pyrroline-2-carboxylate reductase activity" EXACT [EC:1.5.1.1] +synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.5.1.1] +xref: EC:1.5.1.1 +xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050242 +name: pyruvate, phosphate dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate." [EC:2.7.9.1, MetaCyc:PYRUVATE\,ORTHOPHOSPHATE-DIKINASE-RXN] +subset: gosubset_prok +synonym: "ATP:pyruvate, phosphate phosphotransferase activity" EXACT [EC:2.7.9.1] +synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1] +synonym: "PPDK" RELATED [EC:2.7.9.1] +synonym: "pyruvate, Pi dikinase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvate,orthophosphate dikinase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvate,phosphate dikinase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvate-inorganic phosphate dikinase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvate-phosphate dikinase (phosphorylating)" EXACT [EC:2.7.9.1] +synonym: "pyruvate-phosphate dikinase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvate-phosphate ligase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvic-phosphate dikinase activity" EXACT [EC:2.7.9.1] +synonym: "pyruvic-phosphate ligase activity" EXACT [EC:2.7.9.1] +xref: EC:2.7.9.1 +xref: MetaCyc:PYRUVATE\,ORTHOPHOSPHATE-DIKINASE-RXN +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0050243 +name: pyruvate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH." [EC:1.2.1.51, MetaCyc:PYRUVATE-DEHYDROGENASE-(NADP+)-RXN] +synonym: "pyruvate:NADP(+) oxidoreductase activity" EXACT [EC:1.2.1.51] +synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.51] +synonym: "pyruvate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.51] +xref: EC:1.2.1.51 +xref: MetaCyc:PYRUVATE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0050244 +name: pyruvate oxidase (CoA-acetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2." [EC:1.2.3.6, MetaCyc:PYRUVATE-OXIDASE-(COA-ACETYLATING)-RXN] +synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.3.6] +xref: EC:1.2.3.6 +xref: MetaCyc:PYRUVATE-OXIDASE-(COA-ACETYLATING)-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0050245 +name: quercitrinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, MetaCyc:QUERCITRINASE-RXN] +synonym: "quercitrin 3-L-rhamnohydrolase activity" EXACT [EC:3.2.1.66] +xref: EC:3.2.1.66 +xref: MetaCyc:QUERCITRINASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050246 +name: questin monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: questin + NADPH + O2 = sulochrin + NADP+ + H2O." [EC:1.14.13.43, MetaCyc:QUESTIN-MONOOXYGENASE-RXN] +synonym: "questin oxygenase activity" EXACT [EC:1.14.13.43] +synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" EXACT [EC:1.14.13.43] +xref: EC:1.14.13.43 +xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050247 +name: raucaffricine beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN] +synonym: "raucaffricine b-glucosidase activity" EXACT [] +synonym: "raucaffricine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.125] +synonym: "raucaffricine beta-D-glucosidase activity" EXACT [EC:3.2.1.125] +synonym: "raucaffricine glucosidase activity" EXACT [EC:3.2.1.125] +xref: EC:3.2.1.125 +xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050248 +name: Renilla-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN] +synonym: "aequorin activity" NARROW [EC:1.13.12.5] +synonym: "luciferase (Renilla luciferin)" EXACT [EC:1.13.12.5] +synonym: "luciferase activity" BROAD [EC:1.13.12.5] +synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.5] +synonym: "Renilla-type luciferase activity" EXACT [EC:1.13.12.5] +synonym: "renilla-type luciferase activity" EXACT [EC:1.13.12.5] +xref: EC:1.13.12.5 +xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0050249 +name: Renilla-luciferin sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + Renilla luciferin = adenosine 3',5'-bisphosphate + luciferyl sulfate." [EC:2.8.2.10, MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" EXACT [EC:2.8.2.10] +synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" EXACT [EC:2.8.2.10] +synonym: "luciferin sulfokinase activity" EXACT [EC:2.8.2.10] +synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10] +synonym: "Renilla-luciferin sulphotransferase activity" EXACT [] +xref: EC:2.8.2.10 +xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050250 +name: retinal oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN] +synonym: "retinal:oxygen oxidoreductase activity" EXACT [EC:1.2.3.11] +synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11] +xref: EC:1.2.3.11 +xref: MetaCyc:RETINAL-OXIDASE-RXN +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0050251 +name: retinol isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [EC:5.2.1.7, MetaCyc:RETINOL-ISOMERASE-RXN] +synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.7] +synonym: "all-trans-retinol isomerase activity" EXACT [EC:5.2.1.7] +xref: EC:5.2.1.7 +xref: MetaCyc:RETINOL-ISOMERASE-RXN +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050252 +name: retinol O-fatty-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:retinol O-acyltransferase activity" EXACT [EC:2.3.1.76] +synonym: "retinol acyltransferase activity" EXACT [EC:2.3.1.76] +synonym: "retinol fatty-acyltransferase activity" EXACT [EC:2.3.1.76] +xref: EC:2.3.1.76 +xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0050253 +name: retinyl-palmitate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate." [EC:3.1.1.21, MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN] +synonym: "retinyl ester hydrolase activity" EXACT [EC:3.1.1.21] +synonym: "retinyl palmitate hydrolase activity" EXACT [EC:3.1.1.21] +synonym: "retinyl palmitate hydrolyase activity" EXACT [EC:3.1.1.21] +synonym: "retinyl-palmitate palmitohydrolase activity" EXACT [EC:3.1.1.21] +xref: EC:3.1.1.21 +xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050254 +name: rhodopsin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] +synonym: "ATP:rhodopsin phosphotransferase activity" EXACT [EC:2.7.11.14] +synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14] +synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14] +synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14] +synonym: "GRK1" RELATED [EC:2.7.11.14] +synonym: "GRK7" RELATED [EC:2.7.11.14] +synonym: "opsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] +synonym: "opsin kinase activity" EXACT [EC:2.7.11.14] +synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14] +synonym: "RK" RELATED [EC:2.7.11.14] +synonym: "STK14" RELATED [EC:2.7.11.14] +xref: EC:2.7.11.14 +xref: MetaCyc:RHODOPSIN-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050255 +name: ribitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribitol + NAD+ = D-ribulose + NADH." [EC:1.1.1.56, MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "adonitol dehydrogenase activity" EXACT [EC:1.1.1.56] +synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56] +synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] +synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] +synonym: "ribitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.56] +xref: EC:1.1.1.56 +xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050256 +name: ribitol-5-phosphate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.137] +synonym: "dehydrogenase, ribitol 5-phosphate" EXACT [EC:1.1.1.137] +xref: EC:1.1.1.137 +xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050257 +name: riboflavin phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN] +synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] +synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42] +synonym: "G-1-P phosphotransferase activity" EXACT [EC:2.7.1.42] +synonym: "riboflavine phosphotransferase activity" EXACT [EC:2.7.1.42] +xref: EC:2.7.1.42 +xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050258 +name: riboflavinase activity +namespace: molecular_function +def: "Catalysis of the reaction: riboflavin + H2O = ribitol + lumichrome." [EC:3.5.99.1, MetaCyc:RIBOFLAVINASE-RXN] +synonym: "riboflavin hydrolase activity" EXACT [EC:3.5.99.1] +xref: EC:3.5.99.1 +xref: MetaCyc:RIBOFLAVINASE-RXN +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0050259 +name: ribose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose + NADP+ + H2O = D-ribonate + NADPH." [EC:1.1.1.115, MetaCyc:RIBOSE-1-DEHYDROGENASE-(NADP+)-RXN] +synonym: "D-ribose dehydrogenase (NADP+)" EXACT [EC:1.1.1.115] +synonym: "D-ribose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.115] +synonym: "NADP-pentose-dehydrogenase activity" EXACT [EC:1.1.1.115] +xref: EC:1.1.1.115 +xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050260 +name: ribose-5-phosphate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine." [EC:6.3.4.7, MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN] +synonym: "5-phosphoribosylamine synthetase activity" EXACT [EC:6.3.4.7] +synonym: "ammonia-ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] +synonym: "ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7] +synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.7] +xref: EC:6.3.4.7 +xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0050261 +name: ribose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose = D-ribulose." [EC:5.3.1.20, MetaCyc:RIBOSE-ISOMERASE-RXN] +synonym: "D-ribose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.20] +synonym: "D-ribose isomerase activity" EXACT [EC:5.3.1.20] +synonym: "D-ribose ketol-isomerase activity" EXACT [EC:5.3.1.20] +xref: EC:5.3.1.20 +xref: MetaCyc:RIBOSE-ISOMERASE-RXN +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0050262 +name: ribosylnicotinamide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide." [EC:2.7.1.22, MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN] +synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" EXACT [EC:2.7.1.22] +synonym: "ribosylnicotinamide kinase (phosphorylating)" EXACT [EC:2.7.1.22] +xref: EC:2.7.1.22 +xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050263 +name: ribosylpyrimidine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN] +synonym: "N-ribosylpyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] +synonym: "N-ribosylpyrimidine ribohydrolase activity" EXACT [EC:3.2.2.8] +synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8] +synonym: "pyrimidine nucleosidase activity" EXACT [EC:3.2.2.8] +synonym: "pyrimidine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.8] +synonym: "RihB" RELATED [EC:3.2.2.8] +synonym: "YeiK" RELATED [EC:3.2.2.8] +xref: EC:3.2.2.8 +xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0050264 +name: rifamycin-B oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: rifamycin B + O2 = rifamycin O + H2O2." [EC:1.10.3.6, MetaCyc:RIFAMYCIN-B-OXIDASE-RXN] +synonym: "rifamycin B oxidase activity" EXACT [EC:1.10.3.6] +synonym: "rifamycin-B-oxidase activity" EXACT [] +synonym: "rifamycin-B:oxygen oxidoreductase activity" EXACT [EC:1.10.3.6] +xref: EC:1.10.3.6 +xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0050265 +name: RNA uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN] +synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52] +synonym: "TUT activity" EXACT [EC:2.7.7.52] +synonym: "UTP:RNA uridylyltransferase activity" EXACT [] +xref: EC:2.7.7.52 +xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0050266 +name: rosmarinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN] +synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" EXACT [EC:2.3.1.140] +synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" EXACT [EC:2.3.1.140] +synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" EXACT [EC:2.3.1.140] +synonym: "rosmarinic acid synthase activity" EXACT [EC:2.3.1.140] +xref: EC:2.3.1.140 +xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050267 +name: rubber cis-polyprenylcistransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN] +synonym: "cis-prenyl transferase activity" EXACT [EC:2.5.1.20] +synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" EXACT [EC:2.5.1.20] +synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" EXACT [EC:2.5.1.20] +synonym: "rubber allyltransferase activity" EXACT [EC:2.5.1.20] +synonym: "rubber polymerase activity" EXACT [EC:2.5.1.20] +synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20] +synonym: "rubber transferase activity" BROAD [EC:2.5.1.20] +xref: EC:2.5.1.20 +xref: MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050268 +name: coniferyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107] +synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.194] +xref: EC:1.1.1.194 +xref: MetaCyc:RXN-1107 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050269 +name: coniferyl-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241] +subset: gosubset_prok +synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.68] +xref: EC:1.2.1.68 +xref: MetaCyc:RXN-1241 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050270 +name: S-adenosylhomocysteine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3." [EC:3.5.4.28, MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN] +synonym: "adenosylhomocysteine deaminase activity" EXACT [EC:3.5.4.28] +synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" EXACT [EC:3.5.4.28] +xref: EC:3.5.4.28 +xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050271 +name: S-alkylcysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN] +synonym: "alkyl cysteine lyase activity" EXACT [EC:4.4.1.6] +synonym: "alkylcysteine lyase activity" EXACT [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteinase activity" EXACT [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" EXACT [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine lyase activity" EXACT [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.6] +synonym: "S-alkylcysteinase activity" EXACT [EC:4.4.1.6] +xref: EC:4.4.1.6 +xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050272 +name: S-carboxymethylcysteine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride." [EC:4.5.1.5, MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN] +synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" EXACT [EC:4.5.1.5] +synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" EXACT [EC:4.5.1.5] +synonym: "S-carboxymethyl-L-cysteine synthase activity" EXACT [EC:4.5.1.5] +xref: EC:4.5.1.5 +xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0050273 +name: S-succinylglutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + succinate." [EC:3.1.2.13, MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN] +xref: EC:3.1.2.13 +xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0050274 +name: salicyl-alcohol beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + salicyl alcohol = UDP + salicin." [EC:2.4.1.172, MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN] +synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT [] +synonym: "salicyl-alcohol glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] +synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" EXACT [EC:2.4.1.172] +synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172] +synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" EXACT [EC:2.4.1.172] +xref: EC:2.4.1.172 +xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050275 +name: scopoletin glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + scopoletin = UDP + scopolin." [EC:2.4.1.128, MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN] +synonym: "SGTase activity" EXACT [EC:2.4.1.128] +synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] +synonym: "UDPglucose:scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] +synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128] +synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128] +xref: EC:2.4.1.128 +xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050276 +name: scyllo-inosamine 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate." [EC:2.7.1.65, MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN] +synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.65] +synonym: "ATP:inosamine phosphotransferase activity" EXACT [EC:2.7.1.65] +synonym: "scyllo-inosamine kinase (phosphorylating)" EXACT [EC:2.7.1.65] +synonym: "scyllo-inosamine kinase activity" EXACT [] +xref: EC:2.7.1.65 +xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050277 +name: sedoheptulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate." [EC:2.7.1.14, MetaCyc:SEDOHEPTULOKINASE-RXN] +synonym: "ATP:sedoheptulose 7-phosphotransferase activity" EXACT [EC:2.7.1.14] +synonym: "heptulokinase activity" EXACT [EC:2.7.1.14] +synonym: "sedoheptulokinase (phosphorylating)" EXACT [EC:2.7.1.14] +xref: EC:2.7.1.14 +xref: MetaCyc:SEDOHEPTULOKINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050278 +name: sedoheptulose-bisphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "SBPase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose 1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose 1,7-diphosphatase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose bisphosphatase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose diphosphatase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose-1,7-bisphosphatase activity" EXACT [EC:3.1.3.37] +synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.37] +xref: EC:3.1.3.37 +xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050279 +name: sepiapterin deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN] +synonym: "sepiapterin aminohydrolase activity" EXACT [EC:3.5.4.24] +xref: EC:3.5.4.24 +xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050280 +name: sequoyitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-O-methyl-myo-inositol + NAD+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH." [EC:1.1.1.143, MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN] +synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.143] +xref: EC:1.1.1.143 +xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050281 +name: serine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "L-serine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.45] +synonym: "serine--glyoxylate aminotransferase activity" EXACT [] +synonym: "SGAT activity" EXACT [EC:2.6.1.45] +xref: EC:2.6.1.45 +xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050282 +name: serine 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN] +synonym: "L-serine:NAD oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.7] +synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" EXACT [EC:1.4.1.7] +synonym: "serine dehydrogenase activity" EXACT [] +xref: EC:1.4.1.7 +xref: MetaCyc:SERINE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050283 +name: serine-sulfate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + SO4(2-) (sulfate)." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN] +synonym: "(L-SOS)lyase activity" EXACT [EC:4.3.1.10] +synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.10] +synonym: "serine-sulphate ammonia-lyase activity" EXACT [] +xref: EC:4.3.1.10 +xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0050284 +name: sinapate 1-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] +synonym: "UDPglucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120] +synonym: "UDPglucose:sinapic acid glucosyltransferase activity" EXACT [EC:2.4.1.120] +synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" EXACT [EC:2.4.1.120] +synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" EXACT [EC:2.4.1.120] +xref: EC:2.4.1.120 +xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050285 +name: sinapine esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: sinapoylcholine + H2O = sinapate + choline." [EC:3.1.1.49, MetaCyc:SINAPINE-ESTERASE-RXN] +synonym: "aromatic choline esterase activity" EXACT [EC:3.1.1.49] +synonym: "sinapoylcholine sinapohydrolase activity" EXACT [EC:3.1.1.49] +xref: EC:3.1.1.49 +xref: MetaCyc:SINAPINE-ESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050286 +name: sorbitol-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sorbitol 6-phosphate + H2O = sorbitol + phosphate." [EC:3.1.3.50, MetaCyc:SORBITOL-6-PHOSPHATASE-RXN] +synonym: "sorbitol-6-phosphate phosphatase activity" EXACT [EC:3.1.3.50] +synonym: "sorbitol-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.50] +xref: EC:3.1.3.50 +xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050287 +name: sorbose 5-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.123, MetaCyc:SORBOSE-5-DEHYDROGENASE-(NADP+)-RXN] +synonym: "5-keto-D-fructose reductase activity" EXACT [EC:1.1.1.123] +synonym: "5-ketofructose reductase activity" EXACT [EC:1.1.1.123] +synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.123] +synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" EXACT [EC:1.1.1.123] +synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.123] +xref: EC:1.1.1.123 +xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050288 +name: sorbose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-sorbose + acceptor = 5-dehydro-D-fructose + reduced acceptor." [EC:1.1.99.12, MetaCyc:SORBOSE-DEHYDROGENASE-RXN] +synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.12] +synonym: "L-sorbose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.12] +xref: EC:1.1.99.12 +xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050289 +name: spermidine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN] +synonym: "spermidine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.6] +synonym: "spermidine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.6] +xref: EC:1.5.99.6 +xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0050290 +name: sphingomyelin phosphodiesterase D activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingomyelin + H2O = ceramide phosphate + choline." [EC:3.1.4.41, MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN] +synonym: "sphingomyelin ceramide-phosphohydrolase activity" EXACT [EC:3.1.4.41] +synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41] +xref: EC:3.1.4.41 +xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0050291 +name: sphingosine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae, either dihydrosphingosine (DHS) or phytosphingosine (PHS) can react with C26-fattyacyl-CoA to produce ceramide-I or ceramide-II (also called phytoceramide) respectively. In mammals, DHS is usually acylated with a C18 fatty acid group." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845] +synonym: "acyl-CoA:sphingosine N-acyltransferase activity" EXACT [EC:2.3.1.24] +synonym: "ceramide synthase activity" EXACT [] +synonym: "ceramide synthetase activity" EXACT [EC:2.3.1.24] +synonym: "dihydroceramide synthase activity" EXACT [] +synonym: "sphingosine acyltransferase activity" EXACT [EC:2.3.1.24] +xref: EC:2.3.1.24 +xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0050292 +name: steroid 9-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pregna-4,9(11)-diene-3,20-dione + donor-H2 + O2 = 9,11-alpha-epoxypregn-4-ene-3,20-dione + acceptor + H2O." [EC:1.14.99.24, MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN] +synonym: "steroid 9-alpha-hydroxylase activity" EXACT [EC:1.14.99.24] +synonym: "steroid 9a-monooxygenase activity" EXACT [] +synonym: "steroid 9alpha-hydroxylase activity" EXACT [EC:1.14.99.24] +synonym: "steroid 9alpha-monooxygenase activity" EXACT [EC:1.14.99.24] +synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" EXACT [EC:1.14.99.24] +xref: EC:1.14.99.24 +xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050293 +name: steroid-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: testololactone + H2O = testolate." [EC:3.1.1.37, MetaCyc:STEROID-LACTONASE-RXN] +synonym: "testololactone lactonohydrolase activity" EXACT [EC:3.1.1.37] +xref: EC:3.1.1.37 +xref: MetaCyc:STEROID-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050294 +name: steroid sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15] +synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] +synonym: "steroid sulphotransferase activity" EXACT [] +xref: EC:2.8.2.15 +xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN +xref: Reactome:80520 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050295 +name: steryl-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + cholesteryl-beta-D-glucoside = D-glucose + cholesterol." [EC:3.2.1.104, MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN] +synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.104] +synonym: "steryl-b-glucosidase activity" EXACT [] +xref: EC:3.2.1.104 +xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050296 +name: stipitatonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: stipitatonate = stipitatate + CO2." [EC:4.1.1.60, MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN] +synonym: "stipitatonate carboxy-lyase (decyclizing)" EXACT [EC:4.1.1.60] +synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" EXACT [EC:4.1.1.60] +xref: EC:4.1.1.60 +xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050297 +name: stizolobate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN] +synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.29] +xref: EC:1.13.11.29 +xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050298 +name: stizolobinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN] +synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.30] +xref: EC:1.13.11.30 +xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050299 +name: streptomycin 3''-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 3''-phosphate." [EC:2.7.1.87, MetaCyc:STREPTOMYCIN-3''-KINASE-RXN] +subset: gosubset_prok +synonym: "ATP:streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] +synonym: "streptomycin 3''-kinase (phosphorylating)" EXACT [EC:2.7.1.87] +synonym: "streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87] +xref: EC:2.7.1.87 +xref: MetaCyc:STREPTOMYCIN-3''-KINASE-RXN +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0050300 +name: aminoglycoside 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 6-phosphate." [EC:2.7.1.72, MetaCyc:STREPTOMYCIN-6-KINASE-RXN] +subset: gosubset_prok +synonym: "APH(6) activity" EXACT [EC:2.7.1.72] +synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] +synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72] +synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72] +synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72] +synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72] +synonym: "streptomycin 6-kinase activity" NARROW [] +synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72] +synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] +xref: EC:2.7.1.72 +xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0050301 +name: streptomycin-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: streptomycin 6-phosphate + H2O = streptomycin + phosphate." [EC:3.1.3.39, MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "streptomycin 6-phosphate phosphatase activity" EXACT [EC:3.1.3.39] +synonym: "streptomycin 6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] +synonym: "streptomycin-6-P phosphohydrolase activity" EXACT [EC:3.1.3.39] +synonym: "streptomycin-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39] +xref: EC:3.1.3.39 +xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050302 +name: indole-3-acetaldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2 indole acetaldehyde = 2 indole-3-acetic acid (IAA)." [EC:1.2.3.7, MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN] +synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] +synonym: "AO1" RELATED [EC:1.2.3.7] +synonym: "IAA oxidase activity" EXACT [EC:1.2.3.7] +synonym: "IAAld oxidase activity" EXACT [EC:1.2.3.7] +synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7] +synonym: "indoleacetaldehyde oxidase activity" EXACT [EC:1.2.3.7] +xref: EC:1.2.3.7 +xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN +is_a: GO:0018488 ! aryl-aldehyde oxidase activity + +[Term] +id: GO:0050303 +name: lysine 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN] +synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18] +synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18] +synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18] +synonym: "LysDH activity" EXACT [EC:1.4.1.18] +xref: EC:1.4.1.18 +xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN +xref: MetaCyc:PWY-5314 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050304 +name: nitrous-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor." [EC:1.7.99.6, MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "N2O reductase activity" EXACT [EC:1.7.99.6] +synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6] +synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6] +synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.99.6] +xref: EC:1.7.99.6 +xref: MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0050305 +name: strombine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + NAD+ + H2O = glycine + pyruvate + NADH." [EC:1.5.1.22, MetaCyc:STROMBINE-DEHYDROGENASE-RXN] +synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" EXACT [EC:1.5.1.22] +synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" EXACT [EC:1.5.1.22] +synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" EXACT [EC:1.5.1.22] +xref: EC:1.5.1.22 +xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050306 +name: sucrose 1F-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN] +synonym: "SST activity" EXACT [EC:2.4.1.99] +synonym: "sucrose 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.99] +synonym: "sucrose-sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] +synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] +synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] +synonym: "sucrose:sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99] +synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99] +synonym: "sucrose:sucrose fructosyltransferase activity" EXACT [EC:2.4.1.99] +xref: EC:2.4.1.99 +xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0050307 +name: sucrose-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "sucrose 6-phosphate hydrolase activity" EXACT [EC:3.1.3.24] +synonym: "sucrose-6-phosphatase activity" EXACT [EC:3.1.3.24] +synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] +synonym: "sucrose-phosphate hydrolase activity" EXACT [EC:3.1.3.24] +synonym: "sucrose-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24] +xref: EC:3.1.3.24 +xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050308 +name: sugar-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN] +synonym: "sugar-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.23] +xref: EC:3.1.3.23 +xref: MetaCyc:SUGAR-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050309 +name: sugar-terminal-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a sugar phosphate = a sugar + phosphate; an example is D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN] +synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.58] +synonym: "xylitol-5-phosphatase activity" EXACT [EC:3.1.3.58] +xref: EC:3.1.3.58 +xref: MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0050310 +name: sulfite dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: SO3(2-) (sulfite) + 2 ferricytochrome c + H2O = SO4(2-) (sulfate) + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "sulfite cytochrome c reductase activity" EXACT [EC:1.8.2.1] +synonym: "sulfite-cytochrome c oxidoreductase activity" EXACT [EC:1.8.2.1] +synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1] +synonym: "sulphite dehydrogenase activity" EXACT [] +xref: EC:1.8.2.1 +xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN +is_a: GO:0016669 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor + +[Term] +id: GO:0050311 +name: sulfite reductase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = SO3(2-) (sulfite) + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-(FERREDOXIN)-RXN] +subset: gosubset_prok +synonym: "ferredoxin-sulfite reductase activity" EXACT [EC:1.8.7.1] +synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1] +synonym: "sulphite reductase (ferredoxin) activity" EXACT [] +xref: EC:1.8.7.1 +xref: MetaCyc:SULFITE-REDUCTASE-(FERREDOXIN)-RXN +is_a: GO:0016673 ! oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050312 +name: sulfoacetaldehyde lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + SO3(2-) (sulfite)." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN] +comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15). +synonym: "sulphoacetaldehyde lyase activity" EXACT [] +xref: EC:4.4.1.- +xref: MetaCyc:SULFOACETALDEHYDE-LYASE-RXN +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050313 +name: sulfur dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfur + O2 + H2O = SO3(2-) (sulfite)." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN] +synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] +synonym: "sulfur oxygenase activity" EXACT [EC:1.13.11.18] +synonym: "sulfur:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18] +synonym: "sulphur dioxygenase activity" EXACT [] +xref: EC:1.13.11.18 +xref: MetaCyc:SULFUR-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050314 +name: sym-norspermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + propane-1,3-diamine = 5'-methylthioadenosine + bis(3-aminopropyl)amine." [EC:2.5.1.23, MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN] +synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.23] +xref: EC:2.5.1.23 +xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050315 +name: synephrine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-(methylamino)ethanol = (4-hydroxyphenyl)acetaldehyde + methylamine." [EC:4.2.1.88, MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN] +synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" EXACT [EC:4.2.1.88] +xref: EC:4.2.1.88 +xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050316 +name: T2-induced deoxynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dGMP (or dTMP) = ADP + dGDP (or dTDP)." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN] +synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12] +xref: EC:2.7.4.12 +xref: MetaCyc:GMKALT-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0050317 +name: tagatose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-tagatose = ADP + D-tagatose 6-phosphate." [EC:2.7.1.101, MetaCyc:TAGATOSE-KINASE-RXN] +synonym: "ATP:D-tagatose 6-phosphotransferase activity" EXACT [EC:2.7.1.101] +synonym: "D-tagatose 6-phosphate kinase activity" EXACT [EC:2.7.1.101] +synonym: "tagatose 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.101] +xref: EC:2.7.1.101 +xref: MetaCyc:TAGATOSE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050318 +name: tannase activity +namespace: molecular_function +def: "Catalysis of the reaction: digallate + H2O = 2 gallate." [EC:3.1.1.20, MetaCyc:TANNASE-RXN] +synonym: "tannase S" RELATED [EC:3.1.1.20] +synonym: "tannin acetylhydrolase activity" EXACT [EC:3.1.1.20] +synonym: "tannin acylhydrolase activity" EXACT [EC:3.1.1.20] +xref: EC:3.1.1.20 +xref: MetaCyc:TANNASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050319 +name: tartrate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R,R)-tartrate = D-glycerate + CO2." [EC:4.1.1.73, MetaCyc:TARTRATE-DECARBOXYLASE-RXN] +synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" EXACT [EC:4.1.1.73] +synonym: "(R,R)-tartrate carboxy-lyase activity" EXACT [EC:4.1.1.73] +xref: EC:4.1.1.73 +xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050320 +name: tartrate epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R,R)-tartrate = meso-tartrate." [EC:5.1.2.5, MetaCyc:TARTRATE-EPIMERASE-RXN] +synonym: "tartaric racemase activity" EXACT [EC:5.1.2.5] +xref: EC:5.1.2.5 +xref: MetaCyc:TARTRATE-EPIMERASE-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0050321 +name: tau-protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] +synonym: "[Tau protein] kinase activity" EXACT [] +synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26] +synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26] +synonym: "cdk5/p20" RELATED [EC:2.7.11.26] +synonym: "CDK5/p23" RELATED [EC:2.7.11.26] +synonym: "glycogen synthase kinase-3beta activity" EXACT [EC:2.7.11.26] +synonym: "GSK" RELATED [EC:2.7.11.26] +synonym: "protein tau kinase activity" EXACT [EC:2.7.11.26] +synonym: "STK31" RELATED [EC:2.7.11.26] +synonym: "tau kinase activity" EXACT [EC:2.7.11.26] +synonym: "tau protein kinase activity" EXACT [EC:2.7.11.26] +synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26] +synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26] +synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26] +synonym: "TPK" RELATED [EC:2.7.11.26] +synonym: "TPK I" RELATED [EC:2.7.11.26] +synonym: "TPK II" RELATED [EC:2.7.11.26] +synonym: "TTK" RELATED [EC:2.7.11.26] +xref: EC:2.7.11.26 +xref: MetaCyc:TAU-PROTEIN-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050322 +name: taurine-2-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:TAURINE-AMINOTRANSFERASE-RXN] +synonym: "taurine aminotransferase activity" EXACT [] +synonym: "taurine transaminase activity" EXACT [] +synonym: "taurine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] +synonym: "taurine--glutamate transaminase activity" EXACT [EC:2.6.1.55] +synonym: "taurine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.55] +xref: EC:2.6.1.55 +xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050323 +name: taurine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: taurine + H2O + acceptor = sulfoacetaldehyde + NH3 + reduced acceptor." [EC:1.4.99.2, MetaCyc:TAURINE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "taurine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] +synonym: "taurine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.2] +xref: EC:1.4.99.2 +xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0050324 +name: taurocyamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + taurocyamine = ADP + N-phosphotaurocyamine." [EC:2.7.3.4, MetaCyc:TAUROCYAMINE-KINASE-RXN] +synonym: "ATP:taurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.4] +synonym: "ATP:taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] +synonym: "taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4] +xref: EC:2.7.3.4 +xref: MetaCyc:TAUROCYAMINE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0050325 +name: tauropine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tauropine + NAD+ + H2O = taurine + pyruvate + NADH." [EC:1.5.1.23, MetaCyc:TAUROPINE-DEHYDROGENASE-RXN] +synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] +synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23] +xref: EC:1.5.1.23 +xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050326 +name: taxifolin 8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN] +synonym: "taxifolin hydroxylase activity" EXACT [] +synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.19] +xref: EC:1.14.13.19 +xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050327 +name: testosterone 17-beta-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.63, MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN] +synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63] +synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63] +synonym: "17beta-HSD" RELATED [EC:1.1.1.63] +synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" EXACT [EC:1.1.1.63] +synonym: "testosterone 17b-dehydrogenase activity" EXACT [] +synonym: "testosterone 17beta-dehydrogenase activity" EXACT [EC:1.1.1.63] +xref: EC:1.1.1.63 +xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050328 +name: tetrahydroberberine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN] +synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" EXACT [EC:1.3.3.8] +synonym: "(S)-THB oxidase activity" EXACT [EC:1.3.3.8] +synonym: "THB oxidase activity" EXACT [EC:1.3.3.8] +xref: EC:1.3.3.8 +xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050329 +name: tetrahydroxypteridine cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydroxypteridine = xanthine-8-carboxylate." [EC:5.5.1.3, MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN] +synonym: "tetrahydroxypteridine lyase (isomerizing)" EXACT [EC:5.5.1.3] +xref: EC:5.5.1.3 +xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0050330 +name: theanine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine." [EC:3.5.1.65, MetaCyc:THEANINE-HYDROLASE-RXN] +synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] +synonym: "L-theanine amidohydrolase activity" EXACT [EC:3.5.1.65] +synonym: "N5-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65] +xref: EC:3.5.1.65 +xref: MetaCyc:THEANINE-HYDROLASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050331 +name: thiamin diphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN] +synonym: "ATP:thiamin-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] +synonym: "ATP:thiamine-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] +synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" EXACT [EC:2.7.4.15] +synonym: "TDP kinase activity" EXACT [EC:2.7.4.15] +synonym: "thiamin diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15] +synonym: "thiamin pyrophosphate kinase activity" EXACT [EC:2.7.4.15] +synonym: "thiamin-diphosphate kinase activity" EXACT [] +synonym: "thiamine diphosphate kinase activity" EXACT [EC:2.7.4.15] +synonym: "thiamine-diphosphate kinase activity" EXACT [] +xref: EC:2.7.4.15 +xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0050332 +name: thiamin pyridinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiamin + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole." [EC:2.5.1.2, MetaCyc:THIAMIN-PYRIDINYLASE-RXN] +subset: gosubset_prok +synonym: "pyrimidine transferase activity" EXACT [EC:2.5.1.2] +synonym: "thiamin hydrolase activity" EXACT [EC:2.5.1.2] +synonym: "thiamin pyridinolase activity" EXACT [EC:2.5.1.2] +synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] +synonym: "thiaminase I activity" NARROW [EC:2.5.1.2] +synonym: "thiamine hydrolase activity" EXACT [EC:2.5.1.2] +synonym: "thiamine pyridinolase activity" EXACT [EC:2.5.1.2] +synonym: "thiamine pyridinylase activity" EXACT [] +synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2] +xref: EC:2.5.1.2 +xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050333 +name: thiamin-triphosphatase activity +namespace: molecular_function +alt_id: GO:0048253 +def: "Catalysis of the reaction: thiamin triphosphate + H2O = thiamin diphosphate + phosphate." [EC:3.6.1.28, MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN] +synonym: "thiamine-triphosphatase activity" EXACT [] +synonym: "thiamine-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.28] +synonym: "ThTPase activity" EXACT [EC:3.6.1.28] +xref: EC:3.6.1.28 +xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0050334 +name: thiaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiamin + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole." [EC:3.5.99.2, MetaCyc:THIAMINASE-RXN] +synonym: "thiaminase II activity" NARROW [EC:3.5.99.2] +xref: EC:3.5.99.2 +xref: MetaCyc:THIAMINASE-RXN +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0050335 +name: thiocyanate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, MetaCyc:THIOCYANATE-ISOMERASE-RXN] +synonym: "benzyl-thiocyanate isomerase activity" EXACT [EC:5.99.1.1] +synonym: "isothiocyanate isomerase activity" EXACT [EC:5.99.1.1] +xref: EC:5.99.1.1 +xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0050336 +name: thioethanolamine S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine." [EC:2.3.1.11, MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" EXACT [EC:2.3.1.11] +synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" EXACT [EC:2.3.1.11] +synonym: "thioethanolamine acetyltransferase activity" EXACT [EC:2.3.1.11] +synonym: "thioltransacetylase B activity" EXACT [EC:2.3.1.11] +xref: EC:2.3.1.11 +xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0050337 +name: thiosulfate-thiol sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiosulfate + 2 glutathione = SO3(2-) (sulfite) + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN] +synonym: "glutathione-dependent thiosulfate reductase activity" EXACT [EC:2.8.1.3] +synonym: "sulfane reductase activity" EXACT [EC:2.8.1.3] +synonym: "sulfane sulfurtransferase activity" EXACT [EC:2.8.1.3] +synonym: "thiosulfate:thiol sulfurtransferase activity" EXACT [EC:2.8.1.3] +synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT [] +xref: EC:2.8.1.3 +xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0050338 +name: thiosulfate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN] +synonym: "tetrathionate synthase activity" EXACT [EC:1.8.2.2] +synonym: "thiosulfate oxidase activity" EXACT [EC:1.8.2.2] +synonym: "thiosulfate-acceptor oxidoreductase activity" EXACT [EC:1.8.2.2] +synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2] +synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.2] +synonym: "thiosulphate dehydrogenase activity" EXACT [] +xref: EC:1.8.2.2 +xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN +is_a: GO:0016669 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor + +[Term] +id: GO:0050339 +name: thymidine-triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN] +synonym: "deoxythymidine-5'-triphosphatase activity" EXACT [EC:3.6.1.39] +synonym: "dTTP nucleotidohydrolase activity" EXACT [EC:3.6.1.39] +synonym: "dTTPase activity" EXACT [EC:3.6.1.39] +synonym: "thymidine triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.39] +xref: EC:3.6.1.39 +xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0050340 +name: thymidylate 5'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5'-PHOSPHATASE-RXN] +synonym: "deoxythymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] +synonym: "deoxythymidylate phosphohydrolase activity" EXACT [EC:3.1.3.35] +synonym: "deoxythymidylic 5'-nucleotidase activity" EXACT [EC:3.1.3.35] +synonym: "dTMPase activity" EXACT [EC:3.1.3.35] +synonym: "thymidylate 5' phosphatase activity" EXACT [] +synonym: "thymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35] +synonym: "thymidylate 5'-phosphohydrolase activity" EXACT [EC:3.1.3.35] +synonym: "thymidylate nucleotidase activity" EXACT [EC:3.1.3.35] +xref: EC:3.1.3.35 +xref: MetaCyc:THYMIDYLATE-5'-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050341 +name: thymine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN] +synonym: "5-hydroxy-methyluracil dioxygenase activity" EXACT [EC:1.14.11.6] +synonym: "5-hydroxymethyluracil oxygenase activity" EXACT [EC:1.14.11.6] +synonym: "thymine 7-hydroxylase activity" EXACT [EC:1.14.11.6] +synonym: "thymine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.6] +synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.11.6] +xref: EC:1.14.11.6 +xref: MetaCyc:THYMINE-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0050342 +name: tocopherol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN] +synonym: "gamma-tocopherol methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" EXACT [EC:2.1.1.95] +xref: EC:2.1.1.95 +xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0050343 +name: trans-2-enoyl-CoA reductase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-(NAD+)-RXN] +synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44] +xref: EC:1.3.1.44 +xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-(NAD+)-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050344 +name: trans-cinnamate 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cinnamate + NADPH + O2 = 2-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.14, MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN] +synonym: "cinnamate 2-hydroxylase activity" EXACT [EC:1.14.13.14] +synonym: "cinnamate 2-monooxygenase activity" EXACT [EC:1.14.13.14] +synonym: "cinnamic 2-hydroxylase activity" EXACT [EC:1.14.13.14] +synonym: "cinnamic acid 2-hydroxylase activity" EXACT [EC:1.14.13.14] +synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.14] +synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT [] +xref: EC:1.14.13.14 +xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050345 +name: trans-epoxysuccinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + trans-2,3-epoxysuccinate = meso-tartrate." [EC:3.3.2.4, MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN] +synonym: "tartrate epoxydase activity" EXACT [EC:3.3.2.4] +synonym: "trans-2,3-epoxysuccinate hydrolase activity" EXACT [EC:3.3.2.4] +synonym: "trans-epoxysuccinate hydratase activity" EXACT [EC:3.3.2.4] +xref: EC:3.3.2.4 +xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0050346 +name: trans-L-3-hydroxyproline dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-L-3-hydroxyproline = H2O + delta(1)-pyrroline_2-carboxylate." [EC:4.2.1.77, MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN] +synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" EXACT [EC:4.2.1.77] +synonym: "trans-L-3-hydroxyproline hydro-lyase activity" EXACT [EC:4.2.1.77] +xref: EC:4.2.1.77 +xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050347 +name: trans-octaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.11, MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN] +synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" EXACT [EC:2.5.1.11] +synonym: "all-trans-nonaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] +synonym: "nonaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] +synonym: "polyprenylpyrophosphate synthetase activity" EXACT [EC:2.5.1.11] +synonym: "solanesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] +synonym: "solanesyl-diphosphate synthase activity" EXACT [EC:2.5.1.11] +synonym: "SPP synthase activity" EXACT [EC:2.5.1.11] +synonym: "terpenoidallyltransferase activity" EXACT [EC:2.5.1.11] +synonym: "terpenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11] +synonym: "trans-prenyltransferase activity" EXACT [EC:2.5.1.11] +xref: EC:2.5.1.11 +xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050348 +name: trehalose O-mycolyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate." [EC:2.3.1.122, MetaCyc:TREHALOSE-O-MYCOLYLTRANSFERASE-RXN] +subset: gosubset_prok +synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" EXACT [EC:2.3.1.122] +synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" EXACT [EC:2.3.1.122] +xref: EC:2.3.1.122 +xref: MetaCyc:TREHALOSE-O-MYCOLYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050349 +name: triacetate-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: triacetate lactone + H2O = triacetate." [EC:3.1.1.38, MetaCyc:TRIACETATE-LACTONASE-RXN] +synonym: "TAL hydrolase activity" EXACT [EC:3.1.1.38] +synonym: "triacetate lactone hydrolase activity" EXACT [EC:3.1.1.38] +synonym: "triacetic acid lactone hydrolase activity" EXACT [EC:3.1.1.38] +synonym: "triacetic lactone hydrolase activity" EXACT [EC:3.1.1.38] +synonym: "triacetolactone lactonohydrolase activity" EXACT [EC:3.1.1.38] +xref: EC:3.1.1.38 +xref: MetaCyc:TRIACETATE-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050350 +name: trihydroxystilbene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN] +synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95] +synonym: "resveratrol synthase activity" EXACT [EC:2.3.1.95] +synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95] +xref: EC:2.3.1.95 +xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050351 +name: trimetaphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimetaphosphate + H2O = triphosphate." [EC:3.6.1.2, MetaCyc:TRIMETAPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "inorganic trimetaphosphatase activity" EXACT [EC:3.6.1.2] +synonym: "trimetaphosphate hydrolase activity" EXACT [EC:3.6.1.2] +xref: EC:3.6.1.2 +xref: MetaCyc:TRIMETAPHOSPHATASE-RXN +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0050352 +name: trimethylamine-oxide aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (CH3)3NO = (CH3)2NH + formaldehyde." [EC:4.1.2.32, MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN] +synonym: "trimethylamine N-oxide aldolase activity" EXACT [EC:4.1.2.32] +synonym: "trimethylamine N-oxide demethylase activity" EXACT [EC:4.1.2.32] +synonym: "trimethylamine N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] +synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" EXACT [EC:4.1.2.32] +synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32] +xref: EC:4.1.2.32 +xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN +xref: UM-BBD_enzymeID:e0875 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050353 +name: trimethyllysine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2." [EC:1.14.11.8, MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN] +synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] +synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] +synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8] +synonym: "TML dioxygenase activity" EXACT [EC:1.14.11.8] +synonym: "TML hydroxylase activity" EXACT [EC:1.14.11.8] +synonym: "TML-alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] +synonym: "TMLD activity" EXACT [EC:1.14.11.8] +synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] +synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8] +xref: EC:1.14.11.8 +xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0050354 +name: triokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate." [EC:2.7.1.28, MetaCyc:TRIOKINASE-RXN] +synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" EXACT [EC:2.7.1.28] +synonym: "D-triokinase activity" EXACT [EC:2.7.1.28] +synonym: "trio triose kinase (phosphorylating)" EXACT [EC:2.7.1.28] +synonym: "triose kinase activity" EXACT [EC:2.7.1.28] +xref: EC:2.7.1.28 +xref: MetaCyc:TRIOKINASE-RXN +xref: Reactome:70343 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050355 +name: triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: triphosphate + H2O = diphosphate + phosphate." [EC:3.6.1.25, MetaCyc:TRIPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25] +synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25] +xref: EC:3.6.1.25 +xref: MetaCyc:TRIPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0050356 +name: tropine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tropine + NADP+ = tropinone + NADPH." [EC:1.1.1.206, MetaCyc:TROPINE-DEHYDROGENASE-RXN] +synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" EXACT [EC:1.1.1.206] +xref: EC:1.1.1.206 +xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050357 +name: tropinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: atropine + H2O = tropine + tropate." [EC:3.1.1.10, MetaCyc:TROPINESTERASE-RXN] +subset: gosubset_prok +synonym: "atropinase activity" EXACT [EC:3.1.1.10] +synonym: "atropine acylhydrolase activity" EXACT [EC:3.1.1.10] +synonym: "atropine esterase activity" EXACT [EC:3.1.1.10] +synonym: "atropinesterase activity" EXACT [EC:3.1.1.10] +synonym: "tropine esterase activity" EXACT [EC:3.1.1.10] +xref: EC:3.1.1.10 +xref: MetaCyc:TROPINESTERASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050358 +name: tropinone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pseudotropine + NADP+ = tropinone + NADPH." [EC:1.1.1.236, MetaCyc:TROPINONE-REDUCTASE-RXN] +synonym: "pseudotropine forming tropinone reductase activity" EXACT [EC:1.1.1.236] +synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.236] +synonym: "tropinone (psi-tropine-forming) reductase activity" EXACT [EC:1.1.1.236] +synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236] +xref: EC:1.1.1.236 +xref: MetaCyc:TROPINONE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050359 +name: tropomyosin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN] +synonym: "ATP:tropomyosin O-phosphotransferase activity" EXACT [EC:2.7.11.28] +synonym: "STK" RELATED [EC:2.7.11.28] +synonym: "tropomyosin kinase (phosphorylating) activity" EXACT [EC:2.7.11.28] +xref: EC:2.7.11.28 +xref: MetaCyc:TROPOMYOSIN-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050360 +name: tryptophan 2'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2'-DIOXYGENASE-RXN] +synonym: "indole-3-alkane alpha-hydroxylase activity" EXACT [EC:1.13.99.3] +synonym: "indolyl-3-alkan alpha-hydroxylase activity" EXACT [EC:1.13.99.3] +synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" EXACT [EC:1.13.99.3] +synonym: "tryptophan side chain oxidase activity" EXACT [EC:1.13.99.3] +synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3] +synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3] +synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3] +synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3] +synonym: "TSO activity" RELATED [EC:1.13.99.3] +synonym: "TSO I" RELATED [EC:1.13.99.3] +synonym: "TSO II" RELATED [EC:1.13.99.3] +xref: EC:1.13.99.3 +xref: MetaCyc:TRYPTOPHAN-2'-DIOXYGENASE-RXN +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0050361 +name: tryptophan 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + O2 = indole-3-acetamide + CO2 + H2O." [EC:1.13.12.3, MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN] +subset: gosubset_prok +synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.3] +xref: EC:1.13.12.3 +xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050362 +name: tryptophan transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN] +synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" EXACT [EC:2.6.1.27] +synonym: "hydroxytryptophan aminotransferase activity" EXACT [EC:2.6.1.27] +synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.27] +synonym: "L-tryptophan aminotransferase activity" EXACT [EC:2.6.1.27] +synonym: "L-tryptophan transaminase activity" EXACT [EC:2.6.1.27] +synonym: "L-tryptophan:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.27] +synonym: "tryptophan aminotransferase activity" EXACT [] +xref: EC:2.6.1.27 +xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050363 +name: tryptophan dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN] +synonym: "L-Trp-dehydrogenase activity" EXACT [EC:1.4.1.19] +synonym: "L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] +synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.19] +synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19] +synonym: "TDH" RELATED [EC:1.4.1.19] +synonym: "TrpDH activity" EXACT [EC:1.4.1.19] +xref: EC:1.4.1.19 +xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050364 +name: tryptophan dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN] +synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" EXACT [EC:2.5.1.34] +synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] +synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34] +synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" EXACT [EC:2.5.1.34] +synonym: "dimethylallyltryptophan synthetase activity" EXACT [EC:2.5.1.34] +synonym: "DMAT synthetase activity" EXACT [EC:2.5.1.34] +xref: EC:2.5.1.34 +xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050365 +name: tryptophanamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH3." [EC:3.5.1.57, MetaCyc:TRYPTOPHANAMIDASE-RXN] +synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57] +synonym: "L-tryptophanamide amidohydrolase activity" EXACT [EC:3.5.1.57] +synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57] +xref: EC:3.5.1.57 +xref: MetaCyc:TRYPTOPHANAMIDASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050366 +name: tyramine N-feruloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN] +synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] +synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.110] +synonym: "feruloyltyramine synthase activity" EXACT [EC:2.3.1.110] +synonym: "tyramine feruloyltransferase activity" EXACT [EC:2.3.1.110] +synonym: "tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110] +xref: EC:2.3.1.110 +xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050367 +name: tyrosine-arginine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine." [EC:6.3.2.24, MetaCyc:TYROSINE--ARGININE-LIGASE-RXN] +synonym: "kyotorphin synthase activity" EXACT [EC:6.3.2.24] +synonym: "kyotorphin synthetase activity" EXACT [EC:6.3.2.24] +synonym: "kyotorphin-synthesizing enzyme activity" EXACT [EC:6.3.2.24] +synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" EXACT [EC:6.3.2.24] +synonym: "tyrosyl-arginine synthase activity" EXACT [EC:6.3.2.24] +xref: EC:6.3.2.24 +xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0050368 +name: tyrosine 2,3-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, MetaCyc:TYROSINE-2\,3-AMINOMUTASE-RXN] +synonym: "L-tyrosine 2,3-aminomutase activity" EXACT [EC:5.4.3.6] +synonym: "tyrosine alpha,beta-mutase activity" EXACT [EC:5.4.3.6] +xref: EC:5.4.3.6 +xref: MetaCyc:TYROSINE-2\,3-AMINOMUTASE-RXN +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0050369 +name: [tyrosine 3-monooxygenase] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN] +synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" EXACT [EC:2.7.11.6] +synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" EXACT [EC:2.7.11.6] +synonym: "STK4" RELATED [EC:2.7.11.6] +synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.6] +synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] +xref: EC:2.7.11.6 +xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050370 +name: tyrosine N-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [EC:1.14.13.41, MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN] +synonym: "CYP79A1 activity" NARROW [EC:1.14.13.41] +synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [EC:1.14.13.41] +synonym: "tyrosine N-hydroxylase activity" EXACT [] +xref: EC:1.14.13.41 +xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050371 +name: tyrosine phenol-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + H2O = phenol + pyruvate + NH3." [EC:4.1.99.2, MetaCyc:TYROSINE-PHENOL-LYASE-RXN] +subset: gosubset_prok +synonym: "beta-tyrosinase activity" EXACT [EC:4.1.99.2] +synonym: "L-tyrosine phenol-lyase (deaminating)" EXACT [EC:4.1.99.2] +synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.1.99.2] +xref: EC:4.1.99.2 +xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0050372 +name: ubiquitin-calmodulin ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [EC:6.3.2.21, MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN] +synonym: "calmodulin:ubiquitin ligase (AMP-forming)" EXACT [EC:6.3.2.21] +synonym: "ubiquitin-calmodulin synthetase activity" EXACT [EC:6.3.2.21] +synonym: "ubiquityl-calmodulin synthase activity" EXACT [EC:6.3.2.21] +synonym: "ubiquityl-calmodulin synthetase activity" EXACT [EC:6.3.2.21] +synonym: "uCaM-synthetase activity" EXACT [EC:6.3.2.21] +xref: EC:6.3.2.21 +xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN +is_a: GO:0004842 ! ubiquitin-protein ligase activity + +[Term] +id: GO:0050373 +name: UDP-arabinose 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-L-arabinose = UDP-D-xylose." [EC:5.1.3.5, MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN] +synonym: "UDP arabinose epimerase activity" EXACT [EC:5.1.3.5] +synonym: "UDP-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] +synonym: "UDP-D-xylose-4-epimerase activity" EXACT [] +synonym: "UDP-L-arabinose 4-epimerase activity" EXACT [EC:5.1.3.5] +synonym: "UDParabinose 4-epimerase activity" EXACT [EC:5.1.3.5] +synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5] +synonym: "uridine diphosphoarabinose epimerase activity" EXACT [EC:5.1.3.5] +xref: EC:5.1.3.5 +xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050374 +name: UDP-galacturonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-galacturonate = UDP-L-arabinose + CO2." [EC:4.1.1.67, MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN] +synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" EXACT [EC:4.1.1.67] +synonym: "UDP-D-galacturonate carboxy-lyase activity" EXACT [EC:4.1.1.67] +synonym: "UDP-galacturonic acid decarboxylase activity" EXACT [EC:4.1.1.67] +synonym: "UDPgalacturonate decarboxylase activity" EXACT [EC:4.1.1.67] +synonym: "UDPGalUA carboxy lyase activity" EXACT [EC:4.1.1.67] +xref: EC:4.1.1.67 +xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050376 +name: UDP-glucosamine 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucosamine = UDPgalactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN] +synonym: "UDP-glucosamine epimerase activity" EXACT [] +synonym: "UDPglucosamine 4-epimerase activity" EXACT [EC:5.1.3.16] +xref: EC:5.1.3.16 +xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050377 +name: UDP-glucose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose = UDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.76, MetaCyc:UDP-GLUCOSE-4\,6-DEHYDRATASE-RXN] +synonym: "UDP-D-glucose oxidoreductase activity" EXACT [EC:4.2.1.76] +synonym: "UDP-D-glucose-4,6-hydrolyase activity" EXACT [EC:4.2.1.76] +synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.76] +synonym: "UDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] +synonym: "UDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.76] +synonym: "UDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76] +xref: EC:4.2.1.76 +xref: MetaCyc:UDP-GLUCOSE-4\,6-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050378 +name: UDP-glucuronate 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate = UDP-D-galacturonate." [EC:5.1.3.6, MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN] +synonym: "UDP glucuronic epimerase activity" EXACT [EC:5.1.3.6] +synonym: "UDP-D-galacturonic acid 4-epimerase activity" EXACT [EC:5.1.3.6] +synonym: "UDP-galacturonate 4-epimerase activity" EXACT [EC:5.1.3.6] +synonym: "UDPglucuronate 4-epimerase activity" EXACT [EC:5.1.3.6] +synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6] +synonym: "uridine diphosphoglucuronate epimerase activity" EXACT [EC:5.1.3.6] +synonym: "uridine diphosphoglucuronic epimerase activity" EXACT [EC:5.1.3.6] +xref: EC:5.1.3.6 +xref: MetaCyc:PWY-4861 +xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050379 +name: UDP-glucuronate 5'-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate = UDP-L-iduronate." [EC:5.1.3.12, MetaCyc:UDP-GLUCURONATE-5'-EPIMERASE-RXN] +subset: gosubset_prok +synonym: "C-5-uronosyl epimerase activity" EXACT [EC:5.1.3.12] +synonym: "UDP-glucuronate 5' epimerase activity" EXACT [] +synonym: "UDP-glucuronic acid 5'-epimerase activity" EXACT [EC:5.1.3.12] +synonym: "UDP-glucuronic acid epimerase activity" EXACT [EC:5.1.3.12] +synonym: "UDPglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] +synonym: "uridine diphosphoglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12] +xref: EC:5.1.3.12 +xref: MetaCyc:UDP-GLUCURONATE-5'-EPIMERASE-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050380 +name: undecaprenyl-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate." [EC:3.6.1.27, MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN] +subset: gosubset_prok +synonym: "C(55)-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] +synonym: "C(55)-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] +synonym: "C55-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27] +synonym: "C55-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] +synonym: "isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27] +synonym: "undecaprenyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.27] +xref: EC:3.6.1.27 +xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0050381 +name: unspecific monooxygenase activity +namespace: molecular_function +alt_id: GO:0008402 +def: "Catalysis of the reaction: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O." [EC:1.14.14.1] +subset: gosubset_prok +synonym: "aromatase activity" EXACT [] +synonym: "aryl hydrocarbon hydroxylase activity" EXACT [EC:1.14.14.1] +synonym: "aryl-4-monooxygenase activity" EXACT [EC:1.14.14.1] +synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1] +synonym: "cytochrome P450 CYP19" NARROW [] +synonym: "estrogen synthetase activity" NARROW [] +synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1] +synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1] +synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1] +synonym: "microsomal P-450" RELATED [EC:1.14.14.1] +synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1] +synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1] +synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1] +xref: EC:1.14.14.1 +xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0551 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050382 +name: uracil-5-carboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: uracil 5-carboxylate = uracil + CO2." [EC:4.1.1.66, MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN] +synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" EXACT [EC:4.1.1.66] +synonym: "uracil-5-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.66] +synonym: "uracil-5-carboxylic acid decarboxylase activity" EXACT [EC:4.1.1.66] +xref: EC:4.1.1.66 +xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050383 +name: uracil dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.1.99.19, MetaCyc:URACIL-DEHYDROGENASE-RXN] +xref: EC:1.1.99.19 +xref: MetaCyc:URACIL-DEHYDROGENASE-RXN +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050384 +name: urate-ribonucleotide phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: urate D-ribonucleotide + phosphate = urate + D-ribose 1-phosphate." [EC:2.4.2.16, MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN] +synonym: "UAR phosphorylase activity" EXACT [EC:2.4.2.16] +synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.16] +synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.16] +xref: EC:2.4.2.16 +xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0050385 +name: ureidoglycolate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, MetaCyc:UREIDOGLYCOLATE-LYASE-RXN] +synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.3] +synonym: "(S)-ureidoglycolate urea-lyase activity" EXACT [EC:4.3.2.3] +synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3] +synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3] +xref: EC:4.3.2.3 +xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0050386 +name: ureidosuccinase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3." [EC:3.5.1.7, MetaCyc:UREIDOSUCCINASE-RXN] +synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.7] +xref: EC:3.5.1.7 +xref: MetaCyc:UREIDOSUCCINASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050387 +name: urethanase activity +namespace: molecular_function +def: "Catalysis of the reaction: urethane + H2O = ethanol + CO2 + NH3." [EC:3.5.1.75, MetaCyc:URETHANASE-RXN] +synonym: "urethane amidohydrolase (decarboxylating)" EXACT [EC:3.5.1.75] +synonym: "urethane hydrolase activity" EXACT [EC:3.5.1.75] +xref: EC:3.5.1.75 +xref: MetaCyc:URETHANASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050388 +name: uronate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galacturonate + NAD+ + H2O = D-galactarate + NADH." [EC:1.1.1.203, MetaCyc:URONATE-DEHYDROGENASE-RXN] +synonym: "uronate: NAD-oxidoreductase activity" EXACT [EC:1.1.1.203] +synonym: "uronate:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.203] +synonym: "uronic acid dehydrogenase activity" EXACT [EC:1.1.1.203] +xref: EC:1.1.1.203 +xref: MetaCyc:URONATE-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050389 +name: uronolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN] +synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" EXACT [EC:3.1.1.19] +synonym: "glucuronolactonase activity" EXACT [EC:3.1.1.19] +xref: EC:3.1.1.19 +xref: MetaCyc:URONOLACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050390 +name: valine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine = 2-methylpropanamine + CO2." [EC:4.1.1.14, MetaCyc:VALINE-DECARBOXYLASE-RXN] +synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" EXACT [EC:4.1.1.14] +synonym: "L-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] +synonym: "l-valine carboxy-lyase activity" EXACT [EC:4.1.1.14] +synonym: "leucine decarboxylase activity" EXACT [EC:4.1.1.14] +xref: EC:4.1.1.14 +xref: MetaCyc:VALINE-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0655 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050391 +name: valine dehydrogenase (NADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-(NADP+)-RXN] +synonym: "L-valine:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.8] +synonym: "valine dehydrogenase (NADP+) activity" EXACT [] +synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" EXACT [EC:1.4.1.8] +xref: EC:1.4.1.8 +xref: MetaCyc:VALINE-DEHYDROGENASE-(NADP+)-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050392 +name: vicianin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose." [EC:3.2.1.119, MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN] +synonym: "(R)-vicianin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.119] +synonym: "vicianin b-glucosidase activity" EXACT [] +synonym: "vicianin hydrolase activity" EXACT [EC:3.2.1.119] +xref: EC:3.2.1.119 +xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050393 +name: vinylacetyl-CoA delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: vinylacetyl-CoA = crotonyl-CoA." [EC:5.3.3.3, MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN] +subset: gosubset_prok +synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3] +synonym: "vinylacetyl coenzyme A delta-isomerase activity" EXACT [EC:5.3.3.3] +synonym: "vinylacetyl coenzyme A isomerase activity" EXACT [EC:5.3.3.3] +synonym: "vinylacetyl-CoA D-isomerase activity" EXACT [] +synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" EXACT [EC:5.3.3.3] +xref: EC:5.3.3.3 +xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050394 +name: viomycin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN] +subset: gosubset_prok +synonym: "ATP:viomycin O-phosphotransferase activity" EXACT [EC:2.7.1.103] +synonym: "capreomycin phosphotransferase activity" EXACT [EC:2.7.1.103] +synonym: "viomycin phosphotransferase activity" EXACT [EC:2.7.1.103] +xref: EC:2.7.1.103 +xref: MetaCyc:VIOMYCIN-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050395 +name: vitexin beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: vitexin + UDP-D-glucose = vitexin 2'-O-beta-D-glucoside + UDP." [EC:2.4.1.105, MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] +synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105] +synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.105] +synonym: "vitexin b-glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.105 +xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050396 +name: vomifoliol 4'-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (+-)-6-hydroxy-3-oxo-alpha-ionol = NADH + (+-)-6-hydroxy-3-oxo-alpha-ionone." [EC:1.1.1.221, MetaCyc:VOMIFOLIOL-4'-DEHYDROGENASE-RXN] +synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" EXACT [EC:1.1.1.221] +xref: EC:1.1.1.221 +xref: MetaCyc:VOMIFOLIOL-4'-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050397 +name: Watasenia-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN] +synonym: "luciferase activity" BROAD [EC:1.13.12.8] +synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.8] +synonym: "Watasenia-type luciferase activity" EXACT [EC:1.13.12.8] +synonym: "watasenia-type luciferase activity" EXACT [EC:1.13.12.8] +xref: EC:1.13.12.8 +xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0050398 +name: wax-ester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN] +synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50] +synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50] +synonym: "WEH" RELATED [EC:3.1.1.50] +xref: EC:3.1.1.50 +xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050399 +name: xanthommatin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = xanthommatin + NADH." [EC:1.3.1.41, MetaCyc:XANTHOMMATIN-REDUCTASE-RXN] +synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.41] +xref: EC:1.3.1.41 +xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050400 +name: xylitol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + xylitol = ADP + xylitol 5-phosphate." [EC:2.7.1.122, MetaCyc:XYLITOL-KINASE-RXN] +synonym: "ATP:xylitol 5-phosphotransferase activity" EXACT [EC:2.7.1.122] +synonym: "xylitol phosphotransferase activity" EXACT [EC:2.7.1.122] +xref: EC:2.7.1.122 +xref: MetaCyc:XYLITOL-KINASE-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050401 +name: xylonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-xylonate + H2O." [EC:4.2.1.82, MetaCyc:XYLONATE-DEHYDRATASE-RXN] +synonym: "D-xylo-aldonate dehydratase activity" EXACT [EC:4.2.1.82] +synonym: "D-xylonate dehydratase activity" EXACT [EC:4.2.1.82] +synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" EXACT [EC:4.2.1.82] +synonym: "D-xylonate hydro-lyase activity" EXACT [EC:4.2.1.82] +xref: EC:4.2.1.82 +xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050402 +name: xylono-1,4-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-1\,4-LACTONASE-RXN] +synonym: "D-xylono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.68] +synonym: "xylono-g-lactonase activity" EXACT [EC:3.1.1.68] +synonym: "xylonolactonase activity" EXACT [EC:3.1.1.68] +xref: EC:3.1.1.68 +xref: MetaCyc:XYLONO-1\,4-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050403 +name: trans-zeatin O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + trans-zeatin = UDP + O-beta-D-glucosyl-trans-zeatin." [EC:2.4.1.203, MetaCyc:ZEATIN-O-BETA-D-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] +synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] +synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] +synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT [] +synonym: "zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203] +synonym: "zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203] +xref: EC:2.4.1.203 +xref: MetaCyc:RXN-4723 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050404 +name: zeatin O-beta-D-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-xylose + zeatin = UDP + O-beta-D-xylosylzeatin." [EC:2.4.1.204, MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN] +comment: Note that this function was formerly EC:2.4.1.204. +synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.40] +synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" EXACT [EC:2.4.2.40] +synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT [] +synonym: "zeatin O-xylosyltransferase activity" EXACT [EC:2.4.2.40] +xref: EC:2.4.2.40 +xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0050405 +name: [acetyl-CoA carboxylase] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN] +synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" EXACT [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" EXACT [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase activity" EXACT [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-coenzyme A carboxylase kinase activity" EXACT [EC:2.7.11.27] +synonym: "ACK2" RELATED [EC:2.7.11.27] +synonym: "ACK3" RELATED [EC:2.7.11.27] +synonym: "AMPK" RELATED [EC:2.7.11.27] +synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" EXACT [EC:2.7.11.27] +synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27] +synonym: "STK5" RELATED [EC:2.7.11.27] +xref: EC:2.7.11.27 +xref: MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050406 +name: [acetyl-CoA carboxylase]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-PHOSPHATASE-RXN] +synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44] +synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44] +xref: EC:3.1.3.44 +xref: MetaCyc:[ACETYL-COA-CARBOXYLASE\]-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050407 +name: [glycogen-synthase-D] phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:[GLYCOGEN-SYNTHASE-D\]-PHOSPHATASE-RXN] +synonym: "glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "glycogen synthase D phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "glycogen synthetase phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "glycogen-synthase-D phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "Mg2+ dependent glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42] +synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] +synonym: "UDP-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] +synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42] +synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42] +xref: EC:3.1.3.42 +xref: MetaCyc:[GLYCOGEN-SYNTHASE-D\]-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050408 +name: [pyruvate kinase]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:[PYRUVATE-KINASE\]-PHOSPHATASE-RXN] +synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.49] +synonym: "pyruvate kinase phosphatase activity" EXACT [EC:3.1.3.49] +synonym: "pyruvate kinase-phosphatase activity" EXACT [EC:3.1.3.49] +xref: EC:3.1.3.49 +xref: MetaCyc:[PYRUVATE-KINASE\]-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050409 +name: indolylacetylinositol arabinosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside." [EC:2.4.2.34, MetaCyc:2.4.2.34-RXN] +subset: gosubset_prok +synonym: "arabinosylindolylacetylinositol synthase activity" EXACT [EC:2.4.2.34] +synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] +synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34] +xref: EC:2.4.2.34 +xref: MetaCyc:2.4.2.34-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016763 ! transferase activity, transferring pentosyl groups + +[Term] +id: GO:0050410 +name: 3-oxolaurate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxododecanoate = 2-undecanone + CO2." [EC:4.1.1.56, MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN] +synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" EXACT [EC:4.1.1.56] +synonym: "3-oxododecanoate carboxy-lyase activity" EXACT [EC:4.1.1.56] +synonym: "beta-ketoacyl decarboxylase activity" EXACT [EC:4.1.1.56] +synonym: "beta-ketolaurate decarboxylase activity" EXACT [EC:4.1.1.56] +xref: EC:4.1.1.56 +xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050411 +name: agaritine gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] +synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] +synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9] +synonym: "agaritine g-glutamyltransferase activity" EXACT [] +xref: EC:2.3.2.9 +xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN +is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups + +[Term] +id: GO:0050412 +name: cinnamate beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside." [EC:2.4.1.177, MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN] +synonym: "cinnamate b-D-glucosyltransferase activity" EXACT [] +synonym: "cinnamate glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] +synonym: "UDPG:t-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] +synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177] +synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177] +xref: EC:2.4.1.177 +xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050413 +name: D-alanine 2-hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN] +synonym: "2-methylserine hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] +synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" EXACT [EC:2.1.2.7] +synonym: "D-alanine hydroxymethyltransferase activity" EXACT [] +xref: EC:2.1.2.7 +xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0050414 +name: formimidoylaspartate deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN] +synonym: "formiminoaspartate deiminase activity" EXACT [] +synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" EXACT [EC:3.5.3.5] +xref: EC:3.5.3.5 +xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050415 +name: formimidoylglutamase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide." [EC:3.5.3.8, MetaCyc:FORMIMINOGLUTAMASE-RXN] +subset: gosubset_prok +synonym: "formiminoglutamase activity" EXACT [] +synonym: "formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] +synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" EXACT [EC:3.5.3.8] +synonym: "N-formimino-L-glutamate formiminohydrolase activity" EXACT [EC:3.5.3.8] +synonym: "N-formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8] +xref: EC:3.5.3.8 +xref: MetaCyc:FORMIMINOGLUTAMASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050416 +name: formimidoylglutamate deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN] +subset: gosubset_prok +synonym: "formiminoglutamate deiminase activity" EXACT [] +synonym: "formiminoglutamic iminohydrolase activity" EXACT [EC:3.5.3.13] +synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" EXACT [EC:3.5.3.13] +xref: EC:3.5.3.13 +xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050417 +name: glutamin-(asparagin-)ase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-glutamine (or L-asparagine) = NH3 + L-glutamate (or L-aspartate)." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-(ASPARAGIN-)ASE-RXN] +subset: gosubset_prok +synonym: "glutaminase-(asparagin-)ase activity" EXACT [] +synonym: "glutaminase-asparaginase activity" EXACT [EC:3.5.1.38] +synonym: "L-ASNase/L-GLNase activity" EXACT [EC:3.5.1.38] +synonym: "L-asparagine/L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.38] +synonym: "L-glutamine(L-asparagine) amidohydrolase activity" EXACT [EC:3.5.1.38] +xref: EC:3.5.1.38 +xref: MetaCyc:GLUTAMINASE-(ASPARAGIN-)ASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050418 +name: hydroxylamine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN] +subset: gosubset_prok +synonym: "ammonia:(acceptor) oxidoreductase activity" EXACT [EC:1.7.99.1] +synonym: "ammonia:acceptor oxidoreductase activity" EXACT [EC:1.7.99.1] +synonym: "hydroxylamine (acceptor) reductase activity" EXACT [EC:1.7.99.1] +xref: EC:1.7.99.1 +xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0050419 +name: hydroxymandelonitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN] +synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.11] +synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" EXACT [EC:4.1.2.11] +synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11] +synonym: "sorghum hydroxynitrile lyase activity" EXACT [EC:4.1.2.11] +xref: EC:4.1.2.11 +xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050420 +name: maltose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN] +synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" EXACT [EC:2.4.1.139] +xref: EC:2.4.1.139 +xref: MetaCyc:MALTOSE-SYNTHASE-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050421 +name: nitrite reductase (NO-forming) activity +namespace: molecular_function +alt_id: GO:0016666 +def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = NO2(-) (nitrite) + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-(CYTOCHROME)-RXN] +comment: Note that EC:1.7.99.3 was merged into this term. +subset: gosubset_prok +synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1] +synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1] +synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1] +synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" EXACT [EC:1.7.2.1] +synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1] +synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1] +synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1] +synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.1] +synonym: "nitrite reductase (cytochrome) activity" EXACT [] +synonym: "nitrite reductase (cytochrome; NO-forming) activity" EXACT [EC:1.7.2.1] +synonym: "nitrite reductase activity" EXACT [] +synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1] +xref: EC:1.7.2.1 +xref: MetaCyc:NITRITE-REDUCTASE-(CYTOCHROME)-RXN +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0050422 +name: strictosidine beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + strictosidine = D-glucose + strictosidine aglycone." [EC:3.2.1.105, MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN] +synonym: "strictosidine b-glucosidase activity" EXACT [] +synonym: "strictosidine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.105] +xref: EC:3.2.1.105 +xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050423 +name: thiamin oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiamin + 2 O2 = thiamin acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN] +synonym: "thiamin dehydrogenase activity" EXACT [EC:1.1.3.23] +synonym: "thiamin:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] +synonym: "thiamine dehydrogenase activity" EXACT [EC:1.1.3.23] +synonym: "thiamine oxidase activity" EXACT [] +synonym: "thiamine:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23] +xref: EC:1.1.3.23 +xref: MetaCyc:THIAMIN-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050424 +name: alanine carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6] +xref: EC:3.4.17.6 +xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0050425 +name: carboxypeptidase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN] +comment: This term was made obsolete because it represents a gene product. +subset: gosubset_prok +synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2] +synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2] +synonym: "protaminase activity" RELATED [EC:3.4.17.2] +synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2] +xref: EC:3.4.17.2 +xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0050426 +name: peptidyl-glycinamidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2] +synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2] +synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2] +synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2] +synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2] +xref: EC:3.4.19.2 +xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN +is_obsolete: true +replaced_by: GO:0008242 + +[Term] +id: GO:0050427 +name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT [] +synonym: "PAPS metabolic process" EXACT [] +synonym: "PAPS metabolism" EXACT [] +synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT [] +synonym: "phosphoadenosine phosphosulfate metabolism" EXACT [] +xref: MetaCyc:PWY-5340 +xref: Reactome:156584 +xref: Reactome:158468 +xref: Reactome:158849 +xref: Reactome:158860 +xref: Reactome:159358 +xref: Reactome:174362 +xref: Reactome:174389 +xref: Reactome:174392 +xref: Reactome:176474 +xref: Reactome:176494 +xref: Reactome:176517 +xref: Reactome:176521 +xref: Reactome:176585 +xref: Reactome:176588 +xref: Reactome:176604 +xref: Reactome:176606 +xref: Reactome:176609 +xref: Reactome:176631 +xref: Reactome:176646 +xref: Reactome:176664 +xref: Reactome:176669 +xref: Reactome:203534 +xref: Reactome:203616 +xref: Reactome:203626 +xref: Reactome:203848 +xref: Reactome:204453 +xref: Reactome:204553 +xref: Reactome:205710 +xref: Reactome:205906 +xref: Reactome:206295 +xref: Reactome:207161 +xref: Reactome:207637 +xref: Reactome:207827 +xref: Reactome:209347 +xref: Reactome:209612 +xref: Reactome:209613 +xref: Reactome:209980 +xref: Reactome:209997 +xref: Reactome:210480 +xref: Reactome:211125 +xref: Reactome:211582 +xref: Reactome:211630 +xref: Reactome:212501 +xref: Reactome:212594 +xref: Reactome:212602 +xref: Reactome:212848 +xref: Reactome:213451 +xref: Reactome:213560 +xref: Reactome:215070 +xref: Reactome:215474 +xref: Reactome:215875 +xref: Reactome:216730 +xref: Reactome:217133 +xref: Reactome:217355 +xref: Reactome:219111 +xref: Reactome:219350 +xref: Reactome:219351 +xref: Reactome:219803 +xref: Reactome:219820 +xref: Reactome:220324 +xref: Reactome:220973 +xref: Reactome:221358 +xref: Reactome:221402 +xref: Reactome:222306 +xref: Reactome:222330 +xref: Reactome:222340 +xref: Reactome:223249 +xref: Reactome:223376 +xref: Reactome:224343 +xref: Reactome:224630 +xref: Reactome:225018 +xref: Reactome:225614 +xref: Reactome:226027 +xref: Reactome:228158 +xref: Reactome:228421 +xref: Reactome:228902 +xref: Reactome:229998 +xref: Reactome:230038 +xref: Reactome:230935 +xref: Reactome:230948 +xref: Reactome:231705 +xref: Reactome:231829 +xref: Reactome:232927 +xref: Reactome:233157 +xref: Reactome:234263 +xref: Reactome:234736 +xref: Reactome:236371 +xref: Reactome:236649 +xref: Reactome:236992 +xref: Reactome:238018 +xref: Reactome:238055 +xref: Reactome:238973 +xref: Reactome:238974 +xref: Reactome:239647 +xref: Reactome:239772 +xref: Reactome:241122 +xref: Reactome:241127 +xref: Reactome:242014 +xref: Reactome:242408 +xref: Reactome:243500 +xref: Reactome:243662 +xref: Reactome:243986 +xref: Reactome:244632 +xref: Reactome:244670 +xref: Reactome:245319 +xref: Reactome:245320 +xref: Reactome:245896 +xref: Reactome:245979 +xref: Reactome:246654 +xref: Reactome:246727 +xref: Reactome:247388 +xref: Reactome:247658 +xref: Reactome:248581 +xref: Reactome:248733 +xref: Reactome:248986 +xref: Reactome:249571 +xref: Reactome:249600 +xref: Reactome:250429 +xref: Reactome:250902 +xref: Reactome:252398 +xref: Reactome:253268 +xref: Reactome:253981 +xref: Reactome:255556 +xref: Reactome:256380 +xref: Reactome:256457 +xref: Reactome:257018 +xref: Reactome:258930 +xref: Reactome:259908 +xref: Reactome:260632 +xref: Reactome:262304 +xref: Reactome:263194 +xref: Reactome:263665 +xref: Reactome:265155 +xref: Reactome:265648 +xref: Reactome:265656 +xref: Reactome:265968 +xref: Reactome:266079 +xref: Reactome:266611 +xref: Reactome:266613 +xref: Reactome:267031 +xref: Reactome:267165 +xref: Reactome:267710 +xref: Reactome:267768 +xref: Reactome:267899 +xref: Reactome:268257 +xref: Reactome:268281 +xref: Reactome:268969 +xref: Reactome:268970 +xref: Reactome:269813 +xref: Reactome:271288 +xref: Reactome:271290 +xref: Reactome:272054 +xref: Reactome:272294 +xref: Reactome:273166 +xref: Reactome:273244 +xref: Reactome:273430 +xref: Reactome:273942 +xref: Reactome:273962 +xref: Reactome:274830 +xref: Reactome:274831 +xref: Reactome:275724 +xref: Reactome:277376 +xref: Reactome:277378 +xref: Reactome:278034 +xref: Reactome:278300 +xref: Reactome:279648 +xref: Reactome:279729 +xref: Reactome:279887 +xref: Reactome:280421 +xref: Reactome:280441 +xref: Reactome:280891 +xref: Reactome:280962 +xref: Reactome:281800 +xref: Reactome:282769 +xref: Reactome:283770 +xref: Reactome:283826 +xref: Reactome:284492 +xref: Reactome:286463 +xref: Reactome:288764 +xref: Reactome:289066 +xref: Reactome:289783 +xref: Reactome:290736 +xref: Reactome:290882 +xref: Reactome:291684 +xref: Reactome:291960 +xref: Reactome:292027 +xref: Reactome:292359 +xref: Reactome:292571 +xref: Reactome:292576 +xref: Reactome:292804 +xref: Reactome:292914 +xref: Reactome:292916 +xref: Reactome:293181 +xref: Reactome:293200 +xref: Reactome:293436 +xref: Reactome:293466 +xref: Reactome:293476 +xref: Reactome:293642 +xref: Reactome:293662 +is_a: GO:0006790 ! sulfur metabolic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0050428 +name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT [] +synonym: "PAPS biosynthesis" EXACT [] +synonym: "PAPS biosynthetic process" EXACT [] +synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT [] +synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT [] +is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process +is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process + +[Term] +id: GO:0050429 +name: calcium-dependent phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate; requires Ca2+." [EC:3.1.4.3] +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0050430 +name: syntaxin-6 binding +namespace: molecular_function +def: "Interacting selectively with the SNAP receptor syntaxin-6." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0050431 +name: transforming growth factor beta binding +namespace: molecular_function +def: "Interacting selectively with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "TGF-beta binding" EXACT [] +synonym: "TGFbeta binding" EXACT [] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0050432 +name: catecholamine secretion +namespace: biological_process +def: "The regulated release of catecholamines by a cell or group of cells. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] +is_a: GO:0032940 ! secretion by cell +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0050433 +name: regulation of catecholamine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051952 ! regulation of amine transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0050434 +name: positive regulation of viral transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai] +synonym: "activation of viral transcription" NARROW [] +synonym: "stimulation of viral transcription" NARROW [] +synonym: "up regulation of viral transcription" EXACT [] +synonym: "up-regulation of viral transcription" EXACT [] +synonym: "upregulation of viral transcription" EXACT [] +xref: Reactome:167246 +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +is_a: GO:0046782 ! regulation of viral transcription +is_a: GO:0048524 ! positive regulation of viral reproduction +relationship: positively_regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0050435 +name: beta-amyloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai] +subset: gosubset_prok +synonym: "beta-amyloid metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0050436 +name: microfibril binding +namespace: molecular_function +def: "Interacting selectively with a microfibril, any small fibril occurring in biological material." [GOC:ai] +comment: See also the cellular component term 'microfibril ; GO:0001527'. +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050437 +name: (-)-endo-fenchol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + (-)-endo-fenchol." [EC:4.2.3.10, MetaCyc:4.2.3.10-RXN] +synonym: "(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] +synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10] +synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10] +xref: EC:4.2.3.10 +xref: MetaCyc:4.2.3.10-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050438 +name: 2-ethylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA ." [EC:2.3.3.6, MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN] +synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.6] +synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.6] +synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.6] +synonym: "propylmalate synthase activity" EXACT [EC:2.3.3.6] +synonym: "propylmalic synthase activity" EXACT [EC:2.3.3.6] +xref: EC:2.3.3.6 +xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050439 +name: 2-hydroxy-3-oxoadipate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 ." [EC:2.2.1.5, MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN] +synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" EXACT [EC:2.2.1.5] +synonym: "2-hydroxy-3-oxoadipate synthetase activity" EXACT [EC:2.2.1.5] +synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.5] +synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" EXACT [EC:2.2.1.5] +synonym: "oxoglutarate: glyoxylate carboligase activity" EXACT [EC:2.2.1.5] +synonym: "oxoglutarate:glyoxylate carboligase activity" EXACT [EC:2.2.1.5] +xref: EC:2.2.1.5 +xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN +is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups + +[Term] +id: GO:0050440 +name: 2-methylcitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: propanoyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA." [EC:2.3.3.5, MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN] +subset: gosubset_prok +synonym: "2-methylcitrate oxaloacetate-lyase activity" EXACT [EC:2.3.3.5] +synonym: "MCS activity" EXACT [EC:2.3.3.5] +synonym: "methylcitrate synthase activity" EXACT [EC:2.3.3.5] +synonym: "methylcitrate synthetase activity" EXACT [EC:2.3.3.5] +synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" EXACT [EC:2.3.3.5] +xref: EC:2.3.3.5 +xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050441 +name: 3-ethylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA ." [EC:2.3.3.7, MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN] +synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.7] +synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" EXACT [EC:2.3.3.7] +synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" EXACT [EC:2.3.3.7] +xref: EC:2.3.3.7 +xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050442 +name: 3-propylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pentanoyl-CoA + H2O + glyoxylate = 3-propylmalate + CoA ." [EC:2.3.3.12, MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN] +synonym: "3-(n-propyl)-malate synthase activity" EXACT [EC:2.3.3.12] +synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" EXACT [EC:2.3.3.12] +synonym: "beta-n-propylmalate synthase activity" EXACT [EC:2.3.3.12] +synonym: "n-propylmalate synthase activity" EXACT [EC:2.3.3.12] +synonym: "N-propylmalate synthase activity" EXACT [EC:2.3.3.12] +synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" EXACT [EC:2.3.3.12] +xref: EC:2.3.3.12 +xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050444 +name: aquacobalamin reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-(NADPH)-RXN] +synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.16.1.5] +synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.16.1.5] +synonym: "cob(II)alamin:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.5] +synonym: "NADPH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.5] +synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] +synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5] +xref: EC:1.16.1.5 +xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-(NADPH)-RXN +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0050445 +name: asparagusate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + NADH + H+." [EC:1.8.1.11, MetaCyc:ASPARAGUSATE-REDUCTASE-(NADH)-RXN] +synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.11] +synonym: "asparagusate dehydrogenase activity" EXACT [EC:1.8.1.11] +synonym: "asparagusate reductase (NADH) activity" EXACT [] +synonym: "asparagusate reductase (NADH2)" EXACT [EC:1.8.1.11] +synonym: "asparagusic dehydrogenase activity" EXACT [EC:1.8.1.11] +synonym: "NADH2:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] +synonym: "NADH:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11] +xref: EC:1.8.1.11 +xref: MetaCyc:ASPARAGUSATE-REDUCTASE-(NADH)-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050446 +name: azobenzene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN] +synonym: "azo reductase activity" BROAD [EC:1.7.1.6] +synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6] +synonym: "azoreductase activity" BROAD [EC:1.7.1.6] +synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" EXACT [EC:1.7.1.6] +synonym: "dimethylaminobenzene reductase activity" EXACT [EC:1.7.1.6] +synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6] +synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.6] +synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" EXACT [EC:1.7.1.6] +synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" EXACT [EC:1.7.1.6] +synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6] +synonym: "NADPH2-dependent azoreductase activity" EXACT [EC:1.7.1.6] +synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] +synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6] +synonym: "NC-reductase activity" NARROW [EC:1.7.1.6] +synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6] +synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6] +synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" EXACT [EC:1.7.1.6] +synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6] +synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6] +synonym: "p-aminoazobenzene reductase activity" EXACT [EC:1.7.1.6] +synonym: "p-dimethylaminoazobenzene azoreductase activity" EXACT [EC:1.7.1.6] +xref: EC:1.7.1.6 +xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN +xref: UM-BBD_enzymeID:e0514 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050447 +name: zeatin 9-aminocarboxyethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = lupinate + acetate." [EC:2.5.1.50, MetaCyc:BETA-(9-CYTOKININ)-ALANINE-SYNTHASE-RXN] +synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] +synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT [] +synonym: "beta-(9-cytokinin)alanine synthase activity" EXACT [EC:2.5.1.50] +synonym: "lupinate synthetase activity" EXACT [EC:2.5.1.50] +synonym: "lupinic acid synthase activity" EXACT [EC:2.5.1.50] +synonym: "lupinic acid synthetase activity" EXACT [EC:2.5.1.50] +synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" EXACT [EC:2.5.1.50] +synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" EXACT [EC:2.5.1.50] +synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50] +xref: EC:2.5.1.50 +xref: MetaCyc:BETA-(9-CYTOKININ)-ALANINE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050448 +name: beta-cyclopiazonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor." [EC:1.21.99.1, MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN] +synonym: "b-cyclopiazonate dehydrogenase activity" EXACT [] +synonym: "beta-cyclopiazonate oxidocyclase activity" EXACT [EC:1.21.99.1] +synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] +synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1] +synonym: "beta-cyclopiazonic oxidocyclase activity" EXACT [EC:1.21.99.1] +xref: EC:1.21.99.1 +xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0050449 +name: casbene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, MetaCyc:CASBENE-SYNTHASE-RXN] +synonym: "casbene synthetase activity" EXACT [EC:4.2.3.8] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.8] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" EXACT [EC:4.2.3.8] +xref: EC:4.2.3.8 +xref: MetaCyc:CASBENE-SYNTHASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050450 +name: citrate (Re)-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA ." [EC:2.3.3.3, MetaCyc:CITRATE-(RE)-SYNTHASE-RXN] +synonym: "(R)-citrate synthase activity" EXACT [EC:2.3.3.3] +synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3] +synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.3] +synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3] +synonym: "Re-citrate-synthase activity" EXACT [EC:2.3.3.3] +xref: EC:2.3.3.3 +xref: MetaCyc:CITRATE-(RE)-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050451 +name: CoA-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-(NADH)-RXN] +synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14] +synonym: "CoA-disulfide reductase (NADH) activity" EXACT [] +synonym: "CoA-disulfide reductase (NADH2)" EXACT [EC:1.8.1.14] +synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14] +synonym: "CoA-disulphide reductase activity" EXACT [] +synonym: "CoA:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.14] +synonym: "CoA:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.14] +synonym: "CoADR activity" EXACT [EC:1.8.1.14] +synonym: "coenzyme A disulfide reductase activity" EXACT [EC:1.8.1.14] +synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] +synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14] +xref: EC:1.8.1.14 +xref: MetaCyc:COA-DISULFIDE-REDUCTASE-(NADH)-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050452 +name: CoA-glutathione reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-(NADPH)-RXN] +synonym: "CoA-glutathione reductase (NADPH) activity" EXACT [] +synonym: "coenzyme A disulfide-glutathione reductase activity" EXACT [EC:1.8.1.10] +synonym: "coenzyme A glutathione disulfide reductase activity" EXACT [EC:1.8.1.10] +synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10] +synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10] +synonym: "NADPH2:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] +synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10] +xref: EC:1.8.1.10 +xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-(NADPH)-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050453 +name: cob(II)alamin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 cob(I)alamin + NAD+ = 2 cob(II)alamin + NADH + H+." [EC:1.16.1.4, MetaCyc:COB(II)ALAMIN-REDUCTASE-RXN] +synonym: "B(12r) reductase activity" EXACT [EC:1.16.1.4] +synonym: "B12r reductase activity" EXACT [EC:1.16.1.4] +synonym: "cob(I)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.4] +synonym: "NADH2:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] +synonym: "NADH:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4] +synonym: "vitamin B(12r) reductase activity" EXACT [EC:1.16.1.4] +synonym: "vitamin B12 reductase activity" EXACT [] +synonym: "vitamin B12 reduction" RELATED [] +synonym: "vitamin B12r reductase activity" EXACT [EC:1.16.1.4] +xref: EC:1.16.1.4 +xref: MetaCyc:COB(II)ALAMIN-REDUCTASE-RXN +is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0050454 +name: coenzyme F420 hydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + coenzyme F420 = reduced coenzyme F420." [EC:1.12.98.1, MetaCyc:COENZYME-F420-HYDROGENASE-RXN] +subset: gosubset_prok +synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" EXACT [EC:1.12.98.1] +synonym: "coenzyme F420-dependent hydrogenase activity" EXACT [EC:1.12.98.1] +synonym: "F420-reducing hydrogenase activity" EXACT [EC:1.12.98.1] +synonym: "hydrogen:coenzyme F420 oxidoreductase activity" EXACT [EC:1.12.98.1] +xref: EC:1.12.98.1 +xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN +is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors + +[Term] +id: GO:0050455 +name: columbamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O." [EC:1.21.3.2, MetaCyc:COLUMBAMINE-OXIDASE-RXN] +synonym: "berberine synthase activity" EXACT [EC:1.21.3.2] +synonym: "columbamine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.2] +xref: EC:1.21.3.2 +xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0050456 +name: cystine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + NADH + H+." [EC:1.8.1.6, MetaCyc:CYSTINE-REDUCTASE-(NADH)-RXN] +subset: gosubset_prok +synonym: "cystine reductase (NADH) activity" EXACT [EC:1.8.1.6] +synonym: "cystine reductase (NADH2)" EXACT [EC:1.8.1.6] +synonym: "L-cysteine:NAD+ oxidoreductase" EXACT [EC:1.8.1.6] +synonym: "NADH-dependent cystine reductase activity" EXACT [EC:1.8.1.6] +synonym: "NADH2:L-cystine oxidoreductase" EXACT [EC:1.8.1.6] +synonym: "NADH:L-cystine oxidoreductase activity" EXACT [EC:1.8.1.6] +xref: EC:1.8.1.6 +xref: MetaCyc:CYSTINE-REDUCTASE-(NADH)-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050457 +name: decylcitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA ." [EC:2.3.3.2, MetaCyc:DECYLCITRATE-SYNTHASE-RXN] +synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.2] +synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" EXACT [EC:2.3.3.2] +synonym: "2-decylcitrate synthase activity" EXACT [EC:2.3.3.2] +synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.2] +xref: EC:2.3.3.2 +xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050458 +name: decylhomocitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA ." [EC:2.3.3.4, MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN] +synonym: "2-decylhomocitrate synthase activity" EXACT [EC:2.3.3.4] +synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.4] +synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" EXACT [EC:2.3.3.4] +synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.4] +xref: EC:2.3.3.4 +xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050459 +name: ethanolamine-phosphate phospho-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate." [EC:4.2.3.2, MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN] +synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2] +synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" EXACT [EC:4.2.3.2] +synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" EXACT [EC:4.2.3.2] +synonym: "O-phosphoethanolamine-phospholyase activity" EXACT [EC:4.2.3.2] +synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2] +xref: EC:4.2.3.2 +xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050460 +name: hydroxylamine reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-(NADH)-RXN] +synonym: "ammonium dehydrogenase activity" EXACT [EC:1.7.1.10] +synonym: "ammonium:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.10] +synonym: "hydroxylamine reductase (NADH2)" EXACT [EC:1.7.1.10] +synonym: "N-hydroxy amine reductase activity" EXACT [EC:1.7.1.10] +synonym: "NADH-hydroxylamine reductase activity" EXACT [EC:1.7.1.10] +synonym: "NADH2:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] +synonym: "NADH:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10] +xref: EC:1.7.1.10 +xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-(NADH)-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050461 +name: L-mimosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate." [EC:2.5.1.52, MetaCyc:L-MIMOSINE-SYNTHASE-RXN] +synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" EXACT [EC:2.5.1.52] +synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" EXACT [EC:2.5.1.52] +synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52] +xref: EC:2.5.1.52 +xref: MetaCyc:L-MIMOSINE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050462 +name: N-acetylneuraminate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate ." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN] +synonym: "(NANA)condensing enzyme activity" EXACT [EC:2.5.1.56] +synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.56] +synonym: "N-acetylneuraminic acid synthase activity" EXACT [EC:2.5.1.56] +synonym: "NeuAc synthase activity" EXACT [EC:2.5.1.56] +synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.56] +xref: EC:2.5.1.56 +xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050463 +name: nitrate reductase [NAD(P)H] activity +namespace: molecular_function +def: "Catalysis of the reaction: NO2- (nitrite) + NAD(P)+ + H2O = NO3- (nitrate) + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-(NAD(P)H)-RXN] +synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2] +synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2] +synonym: "NAD(P)H bispecific nitrate reductase activity" EXACT [EC:1.7.1.2] +synonym: "NAD(P)H-nitrate reductase activity" EXACT [EC:1.7.1.2] +synonym: "NAD(P)H2:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] +synonym: "NAD(P)H:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2] +synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.2] +synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2] +synonym: "nitrate reductase NAD(P)H activity" EXACT [EC:1.7.1.2] +synonym: "nitrite:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.2] +xref: EC:1.7.1.2 +xref: MetaCyc:NITRATE-REDUCTASE-(NAD(P)H)-RXN +is_a: GO:0008940 ! nitrate reductase activity +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050464 +name: nitrate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN] +synonym: "assimilatory NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] +synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3] +synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" EXACT [EC:1.7.1.3] +synonym: "NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3] +synonym: "NADPH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.3] +synonym: "NADPH:nitrate reductase activity" EXACT [EC:1.7.1.3] +synonym: "nitrate reductase (NADPH(2)) activity" EXACT [EC:1.7.1.3] +synonym: "nitrate reductase (NADPH2)" EXACT [EC:1.7.1.3] +synonym: "nitrite:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.3] +synonym: "triphosphopyridine nucleotide-nitrate reductase activity" EXACT [EC:1.7.1.3] +xref: EC:1.7.1.3 +xref: MetaCyc:NITRATE-REDUCTASE-(NADPH)-RXN +is_a: GO:0008940 ! nitrate reductase activity +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050465 +name: nitroquinoline-N-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN] +synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.9] +synonym: "4-nitroquinoline 1-oxide reductase activity" EXACT [EC:1.7.1.9] +synonym: "4NQO reductase activity" EXACT [EC:1.7.1.9] +synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] +synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9] +xref: EC:1.7.1.9 +xref: MetaCyc:1.7.1.9-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050466 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0046992 + +[Term] +id: GO:0050467 +name: pentalenene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = pentalenene + diphosphate." [EC:4.2.3.7, MetaCyc:PENTALENENE-SYNTHASE-RXN] +subset: gosubset_prok +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] +synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7] +synonym: "pentalenene synthetase activity" EXACT [EC:4.2.3.7] +xref: EC:4.2.3.7 +xref: MetaCyc:PENTALENENE-SYNTHASE-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050468 +name: reticuline oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2." [EC:1.21.3.3, MetaCyc:RETICULINE-OXIDASE-RXN] +synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" EXACT [EC:1.21.3.3] +synonym: "BBE" RELATED [EC:1.21.3.3] +synonym: "berberine bridge enzyme activity" EXACT [EC:1.21.3.3] +synonym: "berberine-bridge-forming enzyme activity" EXACT [EC:1.21.3.3] +synonym: "tetrahydroprotoberberine synthase activity" EXACT [EC:1.21.3.3] +xref: EC:1.21.3.3 +xref: MetaCyc:RETICULINE-OXIDASE-RXN +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0050469 +name: sabinene-hydrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + sabinene hydrate." [EC:4.2.3.11, MetaCyc:4.2.3.11-RXN] +synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" EXACT [EC:4.2.3.11] +synonym: "sabinene hydrate cyclase activity" EXACT [EC:4.2.3.11] +xref: EC:4.2.3.11 +xref: MetaCyc:4.2.3.11-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050470 +name: trimethylamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN] +subset: gosubset_prok +synonym: "TMADh activity" EXACT [EC:1.5.8.2] +synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2] +xref: EC:1.5.8.2 +xref: MetaCyc:1.5.8.2-RXN +xref: UM-BBD_enzymeID:e0854 +is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor + +[Term] +id: GO:0050471 +name: uracilylalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN] +synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] +synonym: "isowillardiine synthase activity" EXACT [EC:2.5.1.53] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" EXACT [EC:2.5.1.53] +synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" EXACT [EC:2.5.1.53] +synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53] +synonym: "willardiine synthase activity" EXACT [EC:2.5.1.53] +synonym: "Willardiine synthase activity" EXACT [EC:2.5.1.53] +xref: EC:2.5.1.53 +xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050472 +name: zeatin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrozeatin + NADP+ = zeatin + NADPH." [EC:1.3.1.69, MetaCyc:ZEATIN-REDUCTASE-RXN] +synonym: "dihydrozeatin:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.69] +xref: EC:1.3.1.69 +xref: MetaCyc:ZEATIN-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050473 +name: arachidonate 15-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33] +subset: gosubset_prok +synonym: "15-lipoxygenase activity" EXACT [EC:1.13.11.33] +synonym: "arachidonate omega(6) lipoxygenase activity" EXACT [EC:1.13.11.33] +synonym: "arachidonate omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] +synonym: "arachidonate:oxygen 15-oxidoreductase activity" EXACT [EC:1.13.11.33] +synonym: "linoleic acid omega6-lipoxygenase activity" EXACT [EC:1.13.11.33] +synonym: "omega6 lipoxygenase activity" EXACT [EC:1.13.11.33] +xref: EC:1.13.11.33 +xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050474 +name: (S)-norcoclaurine synthase activity +namespace: molecular_function +alt_id: GO:0050475 +def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78] +synonym: "(S)-norlaudanosoline synthase activity" EXACT [EC:4.2.1.78] +synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" EXACT [EC:4.2.1.78] +synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78] +xref: EC:4.2.1.78 +xref: MetaCyc:(S)-NORLAUDANOSOLINE-SYNTHASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050476 +name: acetylenedicarboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78] +synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.78] +synonym: "acetylenedicarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.78] +synonym: "acetylenedicarboxylate hydrase activity" EXACT [EC:4.1.1.78] +synonym: "acetylenedicarboxylate hydratase activity" EXACT [EC:4.1.1.78] +xref: EC:4.1.1.78 +xref: MetaCyc:4.1.1.78-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050477 +name: acyl-lysine deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17] +synonym: "6-N-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] +synonym: "epsilon-lysine acylase activity" EXACT [EC:3.5.1.17] +synonym: "N6-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17] +xref: EC:3.5.1.17 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050478 +name: anthranilate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + anthranilate + (tetrahydrobiopterin/tetrahydropteridine) = 3-hydroxanthranilate + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.3, MetaCyc:ANTHRANILATE-3-MONOOXYGENASE-RXN] +synonym: "anthranilate 3-hydroxylase activity" EXACT [] +synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.3] +synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.16.3] +synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.16.3] +xref: EC:1.14.16.3 +xref: MetaCyc:ANTHRANILATE-3-MONOOXYGENASE-RXN +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050479 +name: glyceryl-ether monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN] +synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" EXACT [EC:1.14.16.5] +synonym: "alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] +synonym: "glyceryl ether oxygenase activity" EXACT [EC:1.14.16.5] +synonym: "glyceryl etherase activity" EXACT [EC:1.14.16.5] +synonym: "glyceryl-ether cleaving enzyme activity" EXACT [EC:1.14.16.5] +synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5] +xref: EC:1.14.16.5 +xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050480 +name: imidazolonepropionase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = H+ + N-formimidoyl-L-glutamate." [EC:3.5.2.7, MetaCyc:IMIDAZOLONEPROPIONASE-RXN] +subset: gosubset_prok +synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" EXACT [EC:3.5.2.7] +synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" EXACT [EC:3.5.2.7] +synonym: "imidazolone propionic acid hydrolase activity" EXACT [EC:3.5.2.7] +synonym: "imidazolone-5-propionate hydrolase activity" EXACT [EC:3.5.2.7] +xref: EC:3.5.2.7 +xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0050481 +name: mandelate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + O2 + (tetrahydrobiopterin/tetrahydropteridine) = (S)-4-hydroxymandelate + H2O + (dihydrobiopterin/dihydropteridine). (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN] +synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.6] +synonym: "L-mandelate 4-hydroxylase activity" EXACT [] +synonym: "mandelic acid 4-hydroxylase activity" EXACT [EC:1.14.16.6] +xref: EC:1.14.16.6 +xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050482 +name: arachidonic acid secretion +namespace: biological_process +def: "The regulated release of arachidonic acid from a cell or group of cells." [GOC:ai] +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0050483 +name: IMP 5'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai] +synonym: "IMP 5' nucleotidase activity" EXACT [] +synonym: "IMP-GMP specific 5'-nucleotidase activity" NARROW [] +is_a: GO:0008253 ! 5'-nucleotidase activity + +[Term] +id: GO:0050484 +name: GMP 5'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai] +synonym: "GMP 5' nucleotidase activity" EXACT [] +synonym: "IMP-GMP specific 5'-nucleotidase activity" NARROW [] +is_a: GO:0008253 ! 5'-nucleotidase activity + +[Term] +id: GO:0050485 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT [] +xref: EC:1.21.4 +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0050486 +name: intramolecular transferase activity, transferring hydroxy groups +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah] +subset: gosubset_prok +xref: EC:5.4.4 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0050487 +name: sulfoacetaldehyde acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: SO3(2-) (sulfite) + acetyl phosphate = 2-sulfoacetaldehyde + phosphate." [EC:2.3.3.15] +comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312). +subset: gosubset_prok +synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" EXACT [EC:2.3.3.15] +synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT [] +xref: EC:2.3.3.15 +is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050488 +name: ecdysteroid UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai] +synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050489 +name: ecdysteroid UDP-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate + ecdysteroid = UDP + glucuronosyl-ecdysteroid." [GOC:ai] +synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050490 +name: 1,4-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:1\,4-LACTONASE-RXN] +synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25] +synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25] +xref: EC:3.1.1.25 +xref: MetaCyc:1\,4-LACTONASE-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050491 +name: sulcatone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + sulcatol = NADH + H+ + sulcatone." [EC:1.1.1.260, MetaCyc:1.1.1.260-RXN] +synonym: "sulcatol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.260] +xref: EC:1.1.1.260 +xref: MetaCyc:1.1.1.260-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050492 +name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN] +subset: gosubset_prok +synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261] +xref: EC:1.1.1.261 +xref: MetaCyc:1.1.1.261-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050493 +name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164] +subset: gosubset_prok +synonym: "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0164 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0050494 +name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165] +subset: gosubset_prok +synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] +xref: RESID:AA0165 +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0042082 ! GSI anchor biosynthetic process + +[Term] +id: GO:0050495 +name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346] +subset: gosubset_prok +synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT [] +xref: RESID:AA0346 +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0050496 +name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine +namespace: biological_process +def: "The posttranslational modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347] +subset: gosubset_prok +synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT [] +xref: RESID:AA0340 +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0050497 +name: transferase activity, transferring alkylthio groups +namespace: molecular_function +def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai] +subset: gosubset_prok +xref: EC:2.8.4 +is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups + +[Term] +id: GO:0050498 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah] +subset: gosubset_prok +xref: EC:1.14.20 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050499 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah] +subset: gosubset_prok +xref: EC:1.20.1 +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0050500 +name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1,3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN] +synonym: "1,3-b-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT [] +synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211] +xref: EC:2.4.1.211 +xref: MetaCyc:2.4.1.211-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0050501 +name: hyaluronan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN] +subset: gosubset_prok +synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212] +synonym: "HAS activity" EXACT [EC:2.4.1.212] +synonym: "seHAS" RELATED [EC:2.4.1.212] +synonym: "spHAS" RELATED [EC:2.4.1.212] +xref: EC:2.4.1.212 +xref: MetaCyc:2.4.1.212-RXN +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050502 +name: cis-zeatin O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + UDP." [EC:2.4.1.215, MetaCyc:2.4.1.215-RXN] +synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] +synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215] +xref: EC:2.4.1.215 +xref: MetaCyc:2.4.1.215-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050503 +name: trehalose 6-phosphate phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN] +subset: gosubset_prok +synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.216] +xref: EC:2.4.1.216 +xref: MetaCyc:2.4.1.216-RXN +is_a: GO:0004645 ! phosphorylase activity + +[Term] +id: GO:0050504 +name: mannosyl-3-phosphoglycerate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate." [EC:2.4.1.217, MetaCyc:2.4.1.217-RXN] +subset: gosubset_prok +synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.217] +synonym: "MPG synthase activity" EXACT [EC:2.4.1.217] +xref: EC:2.4.1.217 +xref: MetaCyc:2.4.1.217-RXN +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050505 +name: hydroquinone glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = hydroquinone-O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, MetaCyc:2.4.1.218-RXN] +synonym: "arbutin synthase activity" EXACT [EC:2.4.1.218] +synonym: "hydroquinone:O-glucosyltransferase activity" EXACT [EC:2.4.1.218] +synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] +synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218] +xref: EC:2.4.1.218 +xref: MetaCyc:2.4.1.218-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050506 +name: vomilenine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: vomilenine + UDP-D-glucose = raucaffricine + UDP." [EC:2.4.1.219, MetaCyc:2.4.1.219-RXN] +synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] +synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] +synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219] +synonym: "vomilenine-glucosyltransferase activity" EXACT [EC:2.4.1.219] +xref: EC:2.4.1.219 +xref: MetaCyc:2.4.1.219-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050507 +name: indoxyl-UDPG glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = indican + UDP." [EC:2.4.1.220, MetaCyc:2.4.1.220-RXN] +synonym: "indoxyl-UDPG-glucosyltransferase activity" EXACT [EC:2.4.1.220] +synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.220] +xref: EC:2.4.1.220 +xref: MetaCyc:2.4.1.220-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050508 +name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN] +synonym: "alpha-N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.224] +synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224] +xref: EC:2.4.1.224 +xref: MetaCyc:2.4.1.224-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0050509 +name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN] +synonym: "heparan glucuronyltransferase II activity" EXACT [EC:2.4.1.225] +synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT [] +synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" EXACT [EC:2.4.1.225] +synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.225] +xref: EC:2.4.1.225 +xref: MetaCyc:2.4.1.225-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050510 +name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN] +synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.226] +synonym: "chondroitin glucuronyltransferase II activity" EXACT [EC:2.4.1.226] +synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT [] +xref: EC:2.4.1.226 +xref: MetaCyc:2.4.1.226-RXN +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050511 +name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN] +subset: gosubset_prok +synonym: "MurG transferase activity" RELATED [EC:2.4.1.227] +synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" EXACT [EC:2.4.1.227] +synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" EXACT [EC:2.4.1.227] +synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.227] +synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT [] +xref: EC:2.4.1.227 +xref: MetaCyc:2.4.1.227-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0050512 +name: lactosylceramide 4-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] +synonym: "Gal-beta-1-4Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] +synonym: "galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228] +synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228] +synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228] +synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228] +synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.228] +xref: EC:2.4.1.228 +xref: MetaCyc:2.4.1.228-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0050513 +name: glycoprotein 2-beta-D-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP-L-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP." [EC:2.4.2.38, MetaCyc:2.4.2.38-RXN] +synonym: "beta-1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] +synonym: "beta1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38] +synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT [] +xref: EC:2.4.2.38 +xref: MetaCyc:2.4.2.38-RXN +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0050514 +name: homospermidine synthase (spermidine-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN] +synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" EXACT [EC:2.5.1.45] +xref: EC:2.5.1.45 +xref: MetaCyc:2.5.1.45-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050515 +name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity +namespace: molecular_function +alt_id: GO:0008698 +def: "Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol." [EC:2.7.1.148, MetaCyc:2.7.1.148-RXN] +subset: gosubset_prok +synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" EXACT [EC:2.7.1.148] +synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT [] +synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" EXACT [EC:2.7.1.148] +synonym: "CDP-ME kinase activity" EXACT [EC:2.7.1.148] +synonym: "CMK activity" RELATED [EC:2.7.1.148] +xref: EC:2.7.1.148 +xref: MetaCyc:2.7.1.148-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050516 +name: inositol polyphosphate multikinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN] +comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products. +synonym: "ArgRIII" RELATED [EC:2.7.1.151] +synonym: "AtIpk2-alpha activity" NARROW [EC:2.7.1.151] +synonym: "AtIpk2-beta activity" NARROW [EC:2.7.1.151] +synonym: "AtIpk2alpha" RELATED [EC:2.7.1.151] +synonym: "AtIpk2beta" RELATED [EC:2.7.1.151] +synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.151] +synonym: "inositol polyphosphate 6-/3-/5-kinase activity" EXACT [EC:2.7.1.151] +synonym: "inositol-polyphosphate multikinase activity" EXACT [] +synonym: "IP3/IP4 6-/3-kinase activity" EXACT [EC:2.7.1.151] +synonym: "IP3/IP4 dual-specificity 6-/3-kinase activity" EXACT [EC:2.7.1.151] +synonym: "IpK2 activity" RELATED [EC:2.7.1.151] +synonym: "IpmK" RELATED [EC:2.7.1.151] +xref: EC:2.7.1.151 +xref: MetaCyc:2.7.1.151-RXN +is_obsolete: true + +[Term] +id: GO:0050517 +name: inositol hexakisphosphate kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN] +comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products. +synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.4.21] +synonym: "ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.21] +synonym: "inositol-hexakisphosphate kinase activity" EXACT [] +xref: EC:2.7.4.21 +xref: MetaCyc:2.7.1.152-RXN +is_obsolete: true + +[Term] +id: GO:0050518 +name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity +namespace: molecular_function +alt_id: GO:0008699 +def: "Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol." [EC:2.7.7.60, MetaCyc:2.7.7.60-RXN] +subset: gosubset_prok +synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" EXACT [EC:2.7.7.60] +synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT [] +synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT [] +synonym: "MCT activity" RELATED [EC:2.7.7.60] +synonym: "MEP cytidylyltransferase activity" EXACT [] +xref: EC:2.7.7.60 +xref: MetaCyc:2.7.7.60-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0050519 +name: holo-citrate lyase synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = pyrophosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN] +subset: gosubset_prok +synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" EXACT [EC:2.7.7.61] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" EXACT [EC:2.7.7.61] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" EXACT [EC:2.7.7.61] +synonym: "CitX" RELATED [EC:2.7.7.61] +synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61] +xref: EC:2.7.7.61 +xref: MetaCyc:2.7.7.61-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0050520 +name: phosphatidylcholine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + choline = CMP + phosphatidylcholine." [EC:2.7.8.24, MetaCyc:2.7.8.24-RXN] +subset: gosubset_prok +synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] +synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] +synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24] +synonym: "PC synthase activity" EXACT [EC:2.7.8.24] +xref: EC:2.7.8.24 +xref: MetaCyc:2.7.8.24-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0050521 +name: alpha-glucan, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN] +synonym: "a-glucan, water dikinase activity" EXACT [] +synonym: "alpha-glucan,water dikinase activity" EXACT [EC:2.7.9.4] +synonym: "ATP:alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.4] +synonym: "GWD" RELATED [EC:2.7.9.4] +synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4] +xref: EC:2.7.9.4 +xref: MetaCyc:2.7.9.4-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0050522 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai] +subset: gosubset_prok +xref: EC:1.20.98 +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0050523 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +is_obsolete: true +consider: GO:0030613 + +[Term] +id: GO:0050524 +name: coenzyme-B sulfoethylthiotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane. 2-(methylthio)ethanesulfonate is also known as methyl-CoM; N-(7-mercaptoheptanoyl)threonine 3-O-phosphate is also known as coenzyme B." [EC:2.8.4.1, MetaCyc:2.8.4.1-RXN] +subset: gosubset_prok +synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" EXACT [EC:2.8.4.1] +synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT [] +synonym: "methyl coenzyme M reductase activity" EXACT [EC:2.8.4.1] +synonym: "methyl-CoM reductase activity" EXACT [EC:2.8.4.1] +xref: EC:2.8.4.1 +xref: MetaCyc:2.8.4.1-RXN +is_a: GO:0050497 ! transferase activity, transferring alkylthio groups + +[Term] +id: GO:0050525 +name: cutinase activity +namespace: molecular_function +def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN] +subset: gosubset_prok +synonym: "cutin hydrolase activity" EXACT [EC:3.1.1.74] +xref: EC:3.1.1.74 +xref: MetaCyc:3.1.1.74-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050526 +name: poly(3-hydroxybutyrate) depolymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x = 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN] +subset: gosubset_prok +synonym: "PHB depolymerase activity" EXACT [EC:3.1.1.75] +synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75] +synonym: "poly(3HB) depolymerase activity" EXACT [EC:3.1.1.75] +synonym: "poly(HA(SCL)) depolymerase activity" EXACT [EC:3.1.1.75] +synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75] +synonym: "poly(HASCL) depolymerase activity" EXACT [EC:3.1.1.75] +synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75] +synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75] +xref: EC:3.1.1.75 +xref: MetaCyc:3.1.1.75-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050527 +name: poly(3-hydroxyoctanoate) depolymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x = 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN] +subset: gosubset_prok +synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76] +synonym: "PHO depolymerase activity" EXACT [EC:3.1.1.76] +synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" EXACT [EC:3.1.1.76] +synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76] +synonym: "poly(3HO) depolymerase activity" EXACT [EC:3.1.1.76] +synonym: "poly(HA(MCL)) depolymerase activity" EXACT [EC:3.1.1.76] +synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76] +synonym: "poly(HAMCL) depolymerase activity" EXACT [EC:3.1.1.76] +synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" EXACT [EC:3.1.1.76] +synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76] +synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" EXACT [EC:3.1.1.76] +xref: EC:3.1.1.76 +xref: MetaCyc:3.1.1.76-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050528 +name: acyloxyacyl hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN] +xref: EC:3.1.1.77 +xref: MetaCyc:3.1.1.77-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050529 +name: polyneuridine-aldehyde esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + polyneuridine aldehyde = methanol + CO2 + 16-epivellosimine." [EC:3.1.1.78, MetaCyc:3.1.1.78-RXN] +synonym: "PNAE activity" EXACT [EC:3.1.1.78] +synonym: "polyneuridine aldehyde esterase activity" EXACT [EC:3.1.1.78] +synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" EXACT [EC:3.1.1.78] +xref: EC:3.1.1.78 +xref: MetaCyc:3.1.1.78-RXN +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0050530 +name: glucosylglycerol 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, MetaCyc:3.1.3.69-RXN] +subset: gosubset_prok +synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.69] +synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69] +synonym: "StpA" RELATED [EC:3.1.3.69] +xref: EC:3.1.3.69 +xref: MetaCyc:3.1.3.69-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050531 +name: mannosyl-3-phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, MetaCyc:3.1.3.70-RXN] +subset: gosubset_prok +synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.70] +xref: EC:3.1.3.70 +xref: MetaCyc:3.1.3.70-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050532 +name: 2-phosphosulfolactate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-3-sulfolactate + H2O = 3-sulfolactate + phosphate." [EC:3.1.3.71, MetaCyc:3.1.3.71-RXN] +subset: gosubset_prok +synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] +synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71] +synonym: "2-phosphosulpholactate phosphatase activity" EXACT [] +synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71] +xref: EC:3.1.3.71 +xref: MetaCyc:R229-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050533 +name: 5-phytase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN] +synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.72] +xref: EC:3.1.3.72 +xref: MetaCyc:3.1.3.72-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050534 +name: 3-deoxyoctulosonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN] +synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" EXACT [EC:3.2.1.144] +synonym: "alpha-Kdo-ase activity" EXACT [EC:3.2.1.144] +xref: EC:3.2.1.144 +xref: MetaCyc:3.2.1.144-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050535 +name: beta-primeverosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN] +synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" EXACT [EC:3.2.1.149] +synonym: "b-primeverosidase activity" EXACT [] +xref: EC:3.2.1.149 +xref: MetaCyc:3.2.1.149-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050536 +name: (S)-N-acetyl-1-phenylethylamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylphenylethylamine + H2O = phenylethylamine + acetate." [EC:3.5.1.85, MetaCyc:3.5.1.85-RXN] +synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" EXACT [EC:3.5.1.85] +synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" EXACT [EC:3.5.1.85] +xref: EC:3.5.1.85 +xref: MetaCyc:3.5.1.85-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050537 +name: mandelamide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH3." [EC:3.5.1.86, MetaCyc:3.5.1.86-RXN] +synonym: "mandelamide hydrolase activity" EXACT [EC:3.5.1.86] +synonym: "Pseudomonas mandelamide hydrolase activity" EXACT [EC:3.5.1.86] +xref: EC:3.5.1.86 +xref: MetaCyc:3.5.1.86-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050538 +name: N-carbamoyl-L-amino-acid hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O = L-2-amino acid + NH3 + CO2." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN] +subset: gosubset_prok +synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87] +synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87] +xref: EC:3.5.1.87 +xref: MetaCyc:3.5.1.87-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050539 +name: maleimide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: maleimide + H2O = maleamic acid." [EC:3.5.2.16, MetaCyc:3.5.2.16-RXN] +synonym: "cyclic imide hydrolase activity" EXACT [EC:3.5.2.16] +synonym: "cyclic-imide amidohydrolase (decyclicizing)" EXACT [EC:3.5.2.16] +synonym: "cyclic-imide amidohydrolase (decyclizing)" EXACT [EC:3.5.2.16] +synonym: "imidase activity" BROAD [EC:3.5.2.16] +xref: EC:3.5.2.16 +xref: MetaCyc:3.5.2.16-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0050540 +name: 2-aminomuconate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminomuconate + H2O = 4-oxalocrotonate + NH3." [EC:3.5.99.5, MetaCyc:3.5.99.5-RXN] +subset: gosubset_prok +synonym: "2-aminomuconate aminohydrolase activity" EXACT [EC:3.5.99.5] +xref: EC:3.5.99.5 +xref: MetaCyc:3.5.99.5-RXN +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050541 +name: beta,beta-carotene-9',10'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918] +synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT [] +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050542 +name: icosanoid binding +namespace: molecular_function +def: "Interacting selectively with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "eicosanoid binding" EXACT [] +is_a: GO:0005504 ! fatty acid binding + +[Term] +id: GO:0050543 +name: icosatetraenoic acid binding +namespace: molecular_function +def: "Interacting selectively with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "eicosatetraenoic acid binding" EXACT [] +is_a: GO:0050542 ! icosanoid binding + +[Term] +id: GO:0050544 +name: arachidonic acid binding +namespace: molecular_function +def: "Interacting selectively with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai] +synonym: "arachidonate binding" EXACT [] +is_a: GO:0050543 ! icosatetraenoic acid binding + +[Term] +id: GO:0050545 +name: sulfopyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2." [EC:4.1.1.79, MetaCyc:4.1.1.79-RXN] +subset: gosubset_prok +synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" EXACT [EC:4.1.1.79] +synonym: "sulfopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.79] +synonym: "sulphopyruvate decarboxylase activity" EXACT [] +xref: EC:4.1.1.79 +xref: MetaCyc:R231-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050546 +name: 4-hydroxyphenylpyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2." [EC:4.1.1.80, MetaCyc:4.1.1.80-RXN] +synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" EXACT [EC:4.1.1.80] +synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.80] +xref: EC:4.1.1.80 +xref: MetaCyc:4.1.1.80-RXN +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050547 +name: vanillin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA = vanillin + acetyl-CoA." [EC:4.1.2.41, MetaCyc:4.1.2.41-RXN] +synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] +synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41] +xref: EC:4.1.2.41 +xref: MetaCyc:4.1.2.41-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050548 +name: trans-feruloyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN] +synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" EXACT [EC:4.2.1.101] +synonym: "trans-feruloyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.101] +xref: EC:4.2.1.101 +xref: MetaCyc:4.2.1.101-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050549 +name: cyclohexyl-isocyanide hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclohexylformamide = cyclohexyl isocyanide + H2O." [EC:4.2.1.103, MetaCyc:4.2.1.103-RXN] +subset: gosubset_prok +synonym: "isonitrile hydratase activity" EXACT [EC:4.2.1.103] +synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" EXACT [EC:4.2.1.103] +synonym: "N-cyclohexylformamide hydro-lyase activity" EXACT [EC:4.2.1.103] +xref: EC:4.2.1.103 +xref: MetaCyc:4.2.1.103-RXN +xref: UM-BBD_enzymeID:e0638 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050550 +name: pinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN] +synonym: "(-)-(1S,5S)-pinene synthase activity" EXACT [EC:4.2.3.14] +synonym: "beta-geraniolene synthase activity" EXACT [EC:4.2.3.14] +synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" EXACT [EC:4.2.3.14] +synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" EXACT [EC:4.2.3.14] +xref: EC:4.2.3.14 +xref: MetaCyc:4.2.3.14-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050551 +name: myrcene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = myrcene + diphosphate." [EC:4.2.3.15, MetaCyc:4.2.3.15-RXN] +synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT [] +xref: EC:4.2.3.15 +xref: MetaCyc:RXN-5110 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050552 +name: (4S)-limonene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN] +synonym: "(-)-(4S)-limonene synthase activity" EXACT [] +synonym: "4S-(-)-limonene synthase activity" EXACT [EC:4.2.3.16] +synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16] +synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" EXACT [EC:4.2.3.16] +synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16] +xref: EC:4.2.3.16 +xref: MetaCyc:4.2.3.16-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050553 +name: taxadiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate." [EC:4.2.3.17, MetaCyc:4.2.3.17-RXN] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" EXACT [EC:4.2.3.17] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" EXACT [EC:4.2.3.17] +synonym: "taxa-4(5),11(12)-diene synthase activity" EXACT [EC:4.2.3.17] +xref: EC:4.2.3.17 +xref: MetaCyc:4.2.3.17-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050554 +name: abietadiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, MetaCyc:4.2.3.18-RXN] +synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" EXACT [EC:4.2.3.18] +synonym: "abietadiene cyclase activity" EXACT [EC:4.2.3.18] +synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.18] +xref: EC:4.2.3.18 +xref: MetaCyc:4.2.3.18-RXN +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050555 +name: 2-hydroxypropyl-CoM lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-[or (S)-]2-hydroxypropyl-CoM = H-S-CoM + (R)-[or (S)-]1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN] +subset: gosubset_prok +synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] +synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] +synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23] +synonym: "coenzyme M-epoxyalkane ligase activity" EXACT [EC:4.4.1.23] +synonym: "EaCoMT activity" EXACT [EC:4.4.1.23] +synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" EXACT [EC:4.4.1.23] +synonym: "epoxyalkane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] +synonym: "epoxyalkane:CoM transferase activity" EXACT [EC:4.4.1.23] +synonym: "epoxyalkyl:CoM transferase activity" EXACT [EC:4.4.1.23] +synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23] +synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23] +xref: EC:4.4.1.23 +xref: MetaCyc:4.2.99.19-RXN +xref: UM-BBD_enzymeID:e0538 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050556 +name: deacetylisoipecoside synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: dopamine + secologanin = deacetylisoipecoside + H2O." [EC:4.3.3.3, MetaCyc:4.3.3.3-RXN] +synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.3] +synonym: "deacetylisoipecoside dopamine-lyase activity" EXACT [EC:4.3.3.3] +xref: EC:4.3.3.3 +xref: MetaCyc:4.3.3.3-RXN +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0050557 +name: deacetylipecoside synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: dopamine + secologanin = deacetylipecoside + H2O." [EC:4.3.3.4, MetaCyc:4.3.3.4-RXN] +synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.4] +synonym: "deacetylipecoside dopamine-lyase activity" EXACT [EC:4.3.3.4] +xref: EC:4.3.3.4 +xref: MetaCyc:4.3.3.4-RXN +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0050558 +name: maltose epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, MetaCyc:5.1.3.21-RXN] +synonym: "maltose 1-epimerase activity" EXACT [EC:5.1.3.21] +xref: EC:5.1.3.21 +xref: MetaCyc:5.1.3.21-RXN +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050559 +name: copalyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, MetaCyc:5.5.1.12-RXN] +synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.12] +synonym: "diterpene cyclase activity" BROAD [] +xref: EC:5.5.1.12 +xref: MetaCyc:5.5.1.12-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0050560 +name: aspartate-tRNA(Asn) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + pyrophosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN] +synonym: "aspartate-tRNAAsn ligase activity" EXACT [] +synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23] +synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23] +xref: EC:6.1.1.23 +xref: MetaCyc:6.1.1.23-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0050561 +name: glutamate-tRNA(Gln) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + pyrophosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN] +synonym: "glutamate-tRNAGln ligase activity" EXACT [] +synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" EXACT [EC:6.1.1.24] +synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24] +xref: EC:6.1.1.24 +xref: MetaCyc:6.1.1.24-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0050562 +name: lysine-tRNA(Pyl) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + pyrophosphate + AMP." [EC:6.1.1.25, MetaCyc:6.1.1.25-RXN] +synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [EC:6.1.1.25] +synonym: "lysine-tRNAPyl ligase activity" EXACT [] +xref: EC:6.1.1.25 +xref: MetaCyc:6.1.1.25-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0050563 +name: trans-feruloyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN] +synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34] +synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34] +xref: EC:6.2.1.34 +xref: MetaCyc:6.2.1.34-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050564 +name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H2O = N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate." [EC:6.3.2.26, MetaCyc:6.3.2.26-RXN] +subset: gosubset_prok +synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26] +synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" EXACT [EC:6.3.2.26] +synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" EXACT [EC:6.3.2.26] +synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" EXACT [EC:6.3.2.26] +xref: EC:6.3.2.26 +xref: MetaCyc:6.3.2.26-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0050565 +name: aerobactin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin." [EC:6.3.2.27, MetaCyc:6.3.2.27-RXN] +synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27] +synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27] +xref: EC:6.3.2.27 +xref: MetaCyc:6.3.2.27-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0050566 +name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN] +synonym: "Asp-AdT activity" EXACT [EC:6.3.5.6] +synonym: "Asp-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] +synonym: "Asp-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] +synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] +synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.6] +synonym: "aspartyl-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6] +synonym: "aspartyl-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6] +synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6] +xref: EC:6.3.5.6 +xref: MetaCyc:6.3.5.6-RXN +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0050567 +name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +alt_id: GO:0008264 +alt_id: GO:0017068 +def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] +subset: gosubset_prok +synonym: "Glu-AdT activity" EXACT [EC:6.3.5.-] +synonym: "glu-tRNA(gln) amidotransferase activity" EXACT [EC:6.3.5.-] +synonym: "Glu-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] +synonym: "Glu-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] +synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] +synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.7] +synonym: "glutamyl-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-] +synonym: "glutamyl-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7] +synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7] +xref: EC:6.3.5.- +xref: EC:6.3.5.7 +xref: MetaCyc:6.3.5.7-RXN +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0050568 +name: protein-glutamine glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN] +synonym: "destabilase activity" EXACT [EC:3.5.1.44] +synonym: "glutaminyl-peptide glutaminase activity" EXACT [EC:3.5.1.44] +synonym: "glutaminylpeptide glutaminase activity" EXACT [EC:3.5.1.44] +synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44] +synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44] +synonym: "protein-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.44] +xref: EC:3.5.1.44 +xref: MetaCyc:CHEBDEAMID-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050569 +name: glycolaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+." [EC:1.1.1.262, EC:1.2.1.21, MetaCyc:1.1.1.262-RXN, MetaCyc:GLYCOLALD-DEHYDROG-RXN] +subset: gosubset_prok +synonym: "glycol aldehyde dehydrogenase activity" EXACT [EC:1.2.1.21] +synonym: "glycolaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.21] +xref: EC:1.2.1.21 +xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050570 +name: 4-hydroxythreonine-4-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN] +subset: gosubset_prok +synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" EXACT [EC:1.1.1.262] +synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.262] +synonym: "L-threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] +synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] +synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262] +synonym: "PdxA" RELATED [EC:1.1.1.262] +xref: EC:1.1.1.262 +xref: MetaCyc:1.1.1.262-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050571 +name: 1,5-anhydro-D-fructose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+." [EC:1.1.1.263, MetaCyc:1.1.1.263-RXN] +synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.263] +synonym: "AF reductase activity" EXACT [EC:1.1.1.263] +xref: EC:1.1.1.263 +xref: MetaCyc:1.1.1.263-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050572 +name: L-idonate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN] +subset: gosubset_prok +synonym: "L-idonate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.264] +xref: EC:1.1.1.264 +xref: MetaCyc:1.1.1.264-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050573 +name: dTDP-4-dehydro-6-deoxyglucose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+." [EC:1.1.1.266, MetaCyc:1.1.1.266-RXN] +synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266] +synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266] +xref: EC:1.1.1.266 +xref: MetaCyc:1.1.1.266-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050574 +name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+." [EC:1.1.1.268, MetaCyc:1.1.1.268-RXN] +subset: gosubset_prok +synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.268] +synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.268] +xref: EC:1.1.1.268 +xref: MetaCyc:1.1.1.268-RXN +xref: UM-BBD_enzymeID:e0539 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050575 +name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+." [EC:1.1.1.269, MetaCyc:1.1.1.269-RXN] +subset: gosubset_prok +synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.269] +synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.269] +xref: EC:1.1.1.269 +xref: MetaCyc:1.1.1.269-RXN +xref: UM-BBD_enzymeID:e0540 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050576 +name: 3-keto-steroid reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH + H+." [EC:1.1.1.270, MetaCyc:1.1.1.270-RXN] +synonym: "3-KSR activity" EXACT [EC:1.1.1.270] +synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] +xref: EC:1.1.1.270 +xref: MetaCyc:1.1.1.270-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050577 +name: GDP-L-fucose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN] +subset: gosubset_prok +synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" EXACT [EC:1.1.1.271] +synonym: "GDP-fucose synthetase activity" EXACT [EC:1.1.1.271] +synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" EXACT [EC:1.1.1.271] +xref: EC:1.1.1.271 +xref: MetaCyc:1.1.1.271-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050578 +name: (R)-2-hydroxyacid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN] +subset: gosubset_prok +synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] +synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" EXACT [EC:1.1.1.272] +synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272] +synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272] +xref: EC:1.1.1.272 +xref: MetaCyc:1.1.1.272-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050579 +name: vellosimine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+." [EC:1.1.1.273, MetaCyc:1.1.1.273-RXN] +synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.273] +xref: EC:1.1.1.273 +xref: MetaCyc:1.1.1.273-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050580 +name: 2,5-didehydrogluconate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN] +subset: gosubset_prok +synonym: "2,5-diketo-D-gluconate reductase activity" EXACT [EC:1.1.1.274] +synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.274] +synonym: "YqhE reductase" RELATED [EC:1.1.1.274] +xref: EC:1.1.1.274 +xref: MetaCyc:1.1.1.274-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050581 +name: D-mannitol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN] +synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40] +synonym: "D-arabitol oxidase activity" EXACT [EC:1.1.3.40] +synonym: "mannitol oxidase activity" EXACT [EC:1.1.3.40] +synonym: "mannitol:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.1.3.40] +xref: EC:1.1.3.40 +xref: MetaCyc:1.1.3.40-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050582 +name: xylitol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN] +subset: gosubset_prok +synonym: "xylitol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.41] +xref: EC:1.1.3.41 +xref: MetaCyc:1.1.3.41-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050583 +name: hydrogen dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN] +synonym: "hydrogen:NADP+ oxidoreductase activity" EXACT [EC:1.12.1.3] +synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3] +synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3] +xref: EC:1.12.1.3 +xref: MetaCyc:1.12.1.3-RXN +is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor + +[Term] +id: GO:0050584 +name: linoleate 11-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, MetaCyc:1.13.11.45-RXN] +synonym: "linoleate dioxygenase activity" EXACT [EC:1.13.11.45] +synonym: "linoleate:oxygen 11S-oxidoreductase activity" EXACT [EC:1.13.11.45] +synonym: "manganese lipoxygenase activity" EXACT [EC:1.13.11.45] +xref: EC:1.13.11.45 +xref: MetaCyc:1.13.11.45-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050585 +name: 4-hydroxymandelate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN] +synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46] +synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46] +xref: EC:1.13.11.46 +xref: MetaCyc:1.13.11.46-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050586 +name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO." [EC:1.13.11.48, MetaCyc:1.13.11.48-RXN] +subset: gosubset_prok +synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [EC:1.13.11.48] +synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT [] +synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [] +synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.48] +synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT [] +xref: EC:1.13.11.48 +xref: MetaCyc:1.13.11.48-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050587 +name: chlorite O2-lyase activity +namespace: molecular_function +alt_id: GO:0030065 +def: "Catalysis of the reaction: O2 + Cl- = chlorite." [EC:1.13.11.49, MetaCyc:1.13.11.49-RXN] +synonym: "chloride:oxygen oxidoreductase activity" EXACT [EC:1.13.11.49] +synonym: "chlorite dismutase activity" EXACT [EC:1.13.11.49] +xref: EC:1.13.11.49 +xref: MetaCyc:1.13.11.49-RXN +xref: UM-BBD_enzymeID:e0610 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050588 +name: apo-beta-carotenoid-14',13'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = 14'-apo-beta-carotenal + H2O." [EC:1.13.12.12, MetaCyc:1.13.12.12-RXN] +synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" EXACT [EC:1.13.12.12] +synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT [] +xref: EC:1.13.12.12 +xref: MetaCyc:1.13.12.12-RXN +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050589 +name: leucocyanidin oxygenase activity +namespace: molecular_function +alt_id: GO:0045432 +def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.11.19, MetaCyc:1.14.11.19-RXN] +synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.11.19] +synonym: "leucoanthocyanidin dioxygenase activity" EXACT [EC:1.14.11.19] +synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.11.19] +synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.19] +xref: EC:1.14.11.19 +xref: MetaCyc:RXN-602 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0050590 +name: desacetoxyvindoline 4-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN] +synonym: "D17H activity" RELATED [EC:1.14.11.20] +synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] +synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" EXACT [EC:1.14.11.20] +synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20] +synonym: "desacetoxyvindoline-4-hydroxylase activity" EXACT [EC:1.14.11.20] +synonym: "desacetyoxyvindoline-17-hydroxylase activity" EXACT [EC:1.14.11.20] +xref: EC:1.14.11.20 +xref: MetaCyc:1.14.11.20-RXN +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors + +[Term] +id: GO:0050591 +name: quinine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinine + NADPH + H+ + O2 = 3-hydroxyquinine + NADP+ + H2O." [EC:1.14.13.67, MetaCyc:1.14.13.67-RXN] +synonym: "nifedipine oxidase activity" EXACT [EC:1.14.13.67] +synonym: "quinine 3-hydroxylase activity" EXACT [] +synonym: "quinine,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.67] +xref: EC:1.14.13.67 +xref: MetaCyc:1.14.13.67-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050592 +name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylacetaldehyde oxime + NADPH + H+ + O2 = 4-hydroxymandelonitrile + NADP+ + 2 H2O." [EC:1.14.13.68, MetaCyc:1.14.13.68-RXN] +synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68] +synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" EXACT [EC:1.14.13.68] +synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68] +synonym: "CYP71E1 activity" NARROW [EC:1.14.13.68] +synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.13.68] +synonym: "cytochrome P450II-dependent monooxygenase activity" EXACT [EC:1.14.13.68] +synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" EXACT [EC:1.14.13.68] +xref: EC:1.14.13.68 +xref: MetaCyc:1.14.13.68-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050593 +name: N-methylcoclaurine 3'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3'-hydroxy-N-methylcoclaurine + NADP+ + H2O." [EC:1.14.13.71, MetaCyc:1.14.13.71-RXN] +synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" EXACT [EC:1.14.13.71] +synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.71] +synonym: "cytochrome P450 80B1 activity" EXACT [EC:1.14.13.71] +synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT [] +xref: EC:1.14.13.71 +xref: MetaCyc:1.14.13.71-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050594 +name: tabersonine 16-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tabersonine + NADPH + H+ + O2 = 16-hydroxytabersonine + NADP+ + H2O." [EC:1.14.13.73, MetaCyc:1.14.13.73-RXN] +synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" EXACT [EC:1.14.13.73] +xref: EC:1.14.13.73 +xref: MetaCyc:1.14.13.73-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050595 +name: 7-deoxyloganin 7-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN] +synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.74] +xref: EC:1.14.13.74 +xref: MetaCyc:1.14.13.74-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050596 +name: vinorine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: vinorine + NADPH + H+ + O2 = vomilenine + NADP+ + H2O." [EC:1.14.13.75, MetaCyc:1.14.13.75-RXN] +synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" EXACT [EC:1.14.13.75] +xref: EC:1.14.13.75 +xref: MetaCyc:1.14.13.75-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050597 +name: taxane 10-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-yl acetate = H2O + NADP+ + 10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate." [EC:1.14.13.76, MetaCyc:1.14.13.76-RXN] +synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" EXACT [EC:1.14.13.76] +synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" EXACT [EC:1.14.13.76] +synonym: "taxane 10b-hydroxylase activity" EXACT [] +synonym: "taxane 10beta-hydroxylase activity" EXACT [EC:1.14.13.76] +xref: EC:1.14.13.76 +xref: MetaCyc:1.14.13.76-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050598 +name: taxane 13-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5-alpha,13-alpha-diol." [EC:1.14.13.77, MetaCyc:1.14.13.77-RXN] +synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" EXACT [EC:1.14.13.77] +synonym: "taxane 13a-hydroxylase activity" EXACT [] +synonym: "taxane 13alpha-hydroxylase activity" EXACT [EC:1.14.13.77] +xref: EC:1.14.13.77 +xref: MetaCyc:1.14.13.77-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050599 +name: deacetoxycephalosporin-C synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: penicillin-N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O." [EC:1.14.20.1, MetaCyc:1.14.20.1-RXN] +subset: gosubset_prok +synonym: "DAOC synthase activity" EXACT [EC:1.14.20.1] +synonym: "DAOCS activity" EXACT [EC:1.14.20.1] +synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1] +synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" EXACT [EC:1.14.20.1] +xref: EC:1.14.20.1 +xref: MetaCyc:1.14.20.1-RXN +is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated + +[Term] +id: GO:0050600 +name: myristoyl-CoA 11-(E) desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.31, MetaCyc:1.14.99.31-RXN] +synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] +synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] +xref: EC:1.14.99.31 +xref: MetaCyc:1.14.99.31-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050601 +name: myristoyl-CoA 11-(Z) desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.32, MetaCyc:1.14.99.32-RXN] +synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32] +synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32] +xref: EC:1.14.99.32 +xref: MetaCyc:1.14.99.32-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050602 +name: monoprenyl isoflavone epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN] +synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] +synonym: "7-O-methylluteone:O2 oxidoreductase activity" EXACT [EC:1.14.99.34] +synonym: "monoprenyl isoflavone monooxygenase activity" EXACT [EC:1.14.99.34] +xref: EC:1.14.99.34 +xref: MetaCyc:1.14.99.34-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050603 +name: thiophene-2-carbonyl-CoA monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O." [EC:1.14.99.35, MetaCyc:1.14.99.35-RXN] +synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.35] +synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" EXACT [EC:1.14.99.35] +synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" EXACT [EC:1.14.99.35] +synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" EXACT [EC:1.14.99.35] +xref: EC:1.14.99.35 +xref: MetaCyc:1.14.99.35-RXN +xref: UM-BBD_enzymeID:e0775 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050604 +name: taxadiene 5-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + donor-H2 + taxa-4,11-diene = H2O + acceptor + taxa-4(20),11-dien-5-alpha-ol." [EC:1.14.99.37, MetaCyc:1.14.99.37-RXN] +synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" EXACT [EC:1.14.99.37] +synonym: "taxadiene 5a-hydroxylase activity" EXACT [] +synonym: "taxadiene 5alpha-hydroxylase activity" EXACT [EC:1.14.99.37] +xref: EC:1.14.99.37 +xref: MetaCyc:1.14.99.37-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050605 +name: superoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2(-) + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN] +subset: gosubset_prok +synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2] +synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2] +synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2] +xref: EC:1.15.1.2 +xref: MetaCyc:1.15.1.2-RXN +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0050606 +name: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ = 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + H+." [EC:1.2.1.45, MetaCyc:1.2.1.45-RXN] +synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45] +synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase activity" EXACT [EC:1.2.1.45] +synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.45] +synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45] +xref: EC:1.2.1.45 +xref: MetaCyc:1.2.1.45-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050607 +name: mycothiol-dependent formaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.2.1.66, MetaCyc:1.2.1.66-RXN] +subset: gosubset_prok +synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [EC:1.2.1.66] +synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.2.1.66] +xref: EC:1.2.1.66 +xref: MetaCyc:1.2.1.66-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050608 +name: vanillin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillin + NAD+ + H2O = vanillate + NADH + H+." [EC:1.2.1.67, MetaCyc:1.2.1.67-RXN] +synonym: "vanillin:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.67] +xref: EC:1.2.1.67 +xref: MetaCyc:1.2.1.67-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050609 +name: phosphonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphonate + NAD+ + H2O = phosphate + NADH + H+." [EC:1.20.1.1, MetaCyc:1.20.1.1-RXN] +subset: gosubset_prok +synonym: "NAD-dependent phosphite dehydrogenas activity" EXACT [EC:1.20.1.1] +synonym: "NAD:phosphite oxidoreductase activity" EXACT [EC:1.20.1.1] +synonym: "phosphite dehydrogenase activity" EXACT [EC:1.20.1.1] +synonym: "phosphonate:NAD+ oxidoreductase activity" EXACT [EC:1.20.1.1] +xref: EC:1.20.1.1 +xref: MetaCyc:1.20.1.1-RXN +xref: UM-BBD_enzymeID:e0658 +is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor + +[Term] +id: GO:0050610 +name: methylarsonate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced glutathione + methylarsonate = oxidized glutathione + methylarsonite." [EC:1.20.4.2, MetaCyc:1.20.4.2-RXN] +synonym: "gluthathione:methylarsonate oxidoreductase activity" EXACT [EC:1.20.4.2] +synonym: "MMA(V) reductase activity" EXACT [EC:1.20.4.2] +xref: EC:1.20.4.2 +xref: MetaCyc:1.20.4.2-RXN +xref: UM-BBD_enzymeID:e0528 +is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor + +[Term] +id: GO:0050611 +name: arsenate reductase (azurin) activity +namespace: molecular_function +def: "Catalysis of the reaction: azurin(ox) + H2O + arsenite = azurin(red) + arsenate." [EC:1.20.98.1, MetaCyc:1.20.98.1-RXN] +subset: gosubset_prok +synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.98.1] +xref: EC:1.20.98.1 +xref: MetaCyc:1.20.98.1-RXN +is_a: GO:0050522 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors + +[Term] +id: GO:0050612 +name: arsenate reductase (donor) activity +namespace: molecular_function +def: "Catalysis of the reaction: acceptor + arsenite = donor-H2 + arsenate." [EC:1.20.99.1, MetaCyc:1.20.99.1-RXN] +synonym: "arsenate:(acceptor) oxidoreductase activity" EXACT [EC:1.20.99.1] +synonym: "arsenate:acceptor oxidoreductase activity" EXACT [EC:1.20.99.1] +xref: EC:1.20.99.1 +xref: MetaCyc:1.20.99.1-RXN +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0050613 +name: delta14-sterol reductase activity +namespace: molecular_function +alt_id: GO:0000251 +def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" EXACT [EC:1.3.1.70] +synonym: "C-14 sterol reductase activity" EXACT [] +synonym: "D14-sterol reductase activity" EXACT [] +synonym: "sterol C-14 reductase activity" EXACT [] +synonym: "sterol C14-reductase activity" EXACT [EC:1.3.1.70] +xref: EC:1.3.1.70 +xref: MetaCyc:1.3.1.70-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050614 +name: delta24-sterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN] +synonym: "D24-sterol reductase activity" EXACT [] +synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72] +synonym: "lanosterol delta24-reductase activity" EXACT [EC:1.3.1.72] +synonym: "sterol:NADP+ delta24-oxidoreductase activity" EXACT [EC:1.3.1.72] +xref: EC:1.3.1.72 +xref: MetaCyc:1.3.1.72-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050615 +name: 1,2-dihydrovomilenine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + NADPH + H+." [EC:1.3.1.73, MetaCyc:1.3.1.73-RXN] +synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.73] +xref: EC:1.3.1.73 +xref: MetaCyc:1.3.1.73-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050616 +name: secologanin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.3.3.9, MetaCyc:1.3.3.9-RXN] +synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" EXACT [EC:1.3.3.9] +xref: EC:1.3.3.9 +xref: MetaCyc:1.3.3.9-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050617 +name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN] +subset: gosubset_prok +synonym: "PebA" RELATED [EC:1.3.7.2] +xref: EC:1.3.7.2 +xref: MetaCyc:1.3.7.2-RXN +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050618 +name: phycoerythrobilin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN] +subset: gosubset_prok +synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.3] +synonym: "PebB" RELATED [EC:1.3.7.3] +xref: EC:1.3.7.3 +xref: MetaCyc:1.3.7.3-RXN +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050619 +name: phytochromobilin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN] +synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.4] +synonym: "HY2" RELATED [EC:1.3.7.4] +synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4] +synonym: "PFB synthase activity" EXACT [EC:1.3.7.4] +synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4] +synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4] +xref: EC:1.3.7.4 +xref: MetaCyc:1.3.7.4-RXN +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050620 +name: phycocyanobilin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN] +subset: gosubset_prok +synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5] +xref: EC:1.3.7.5 +xref: MetaCyc:1.3.7.5-RXN +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050621 +name: tryptophan alpha,beta-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2." [EC:1.3.3.10, MetaCyc:1.4.3.17-RXN] +comment: Note that this was EC:1.4.3.17. +synonym: "L-tryptophan 2',3'-oxidase activity" EXACT [EC:1.3.3.10] +synonym: "L-tryptophan alpha,beta-dehydrogenase activity" EXACT [EC:1.3.3.10] +synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" EXACT [EC:1.3.3.10] +synonym: "tryptophan a,b-oxidase activity" EXACT [] +xref: EC:1.3.3.10 +xref: MetaCyc:1.4.3.17-RXN +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050622 +name: glycine dehydrogenase (cyanide-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN] +synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" EXACT [EC:1.4.99.5] +synonym: "HCN synthase activity" EXACT [EC:1.4.99.5] +synonym: "hydrogen cyanide synthase activity" EXACT [EC:1.4.99.5] +xref: EC:1.4.99.5 +xref: MetaCyc:1.4.99.5-RXN +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0050623 +name: berberine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+." [EC:1.5.1.31, MetaCyc:1.5.1.31-RXN] +synonym: "(R)-canadine synthase activity" EXACT [EC:1.5.1.31] +synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.31] +xref: EC:1.5.1.31 +xref: MetaCyc:1.5.1.31-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050624 +name: vomilenine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+." [EC:1.5.1.32, MetaCyc:1.5.1.32-RXN] +synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.32] +xref: EC:1.5.1.32 +xref: MetaCyc:1.5.1.32-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050625 +name: 2-hydroxy-1,4-benzoquinone reductase activity +namespace: molecular_function +alt_id: GO:0018540 +def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + NADH + H+ = NAD+ + 1,2,4-benzenetriol." [EC:1.6.5.7, MetaCyc:1.6.5.7-RXN] +synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" EXACT [EC:1.6.5.7] +synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" EXACT [EC:1.6.5.7] +synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" EXACT [EC:1.6.5.7] +synonym: "hydroxybenzoquinone reductase activity" EXACT [EC:1.6.5.-] +synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.7] +xref: EC:1.6.5.- +xref: EC:1.6.5.7 +xref: MetaCyc:1.6.5.7-RXN +xref: UM-BBD_enzymeID:e0424 +is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor + +[Term] +id: GO:0050626 +name: trimethylamine-N-oxide reductase (cytochrome c) activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ ." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN] +subset: gosubset_prok +synonym: "TMAO reductase activity" EXACT [EC:1.7.2.3] +synonym: "TOR activity" EXACT [EC:1.7.2.3] +synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3] +xref: EC:1.7.2.3 +xref: MetaCyc:1.7.2.3-RXN +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0050627 +name: mycothione reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN] +synonym: "mycothiol-disulfide reductase activity" EXACT [EC:1.8.1.15] +synonym: "mycothiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.15] +xref: EC:1.8.1.15 +xref: MetaCyc:1.8.1.15-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050628 +name: 2-oxopropyl-CoM reductase (carboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+." [EC:1.8.1.5, MetaCyc:1.8.1.5-RXN] +subset: gosubset_prok +synonym: "2-KPCC activity" EXACT [EC:1.8.1.5] +synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.8.1.5] +synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] +synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5] +xref: EC:1.8.1.5 +xref: MetaCyc:1.8.1.5-RXN +xref: UM-BBD_enzymeID:e0541 +is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050629 +name: tetrachloroethene reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.97.1.8, MetaCyc:1.97.1.8-RXN] +subset: gosubset_prok +synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" EXACT [EC:1.97.1.8] +synonym: "tetrachloroethene reductase activity" EXACT [EC:1.97.1.8] +xref: EC:1.97.1.8 +xref: MetaCyc:1.97.1.8-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0050630 +name: (iso)eugenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN] +synonym: "isoeugenol O-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" EXACT [EC:2.1.1.146] +xref: EC:2.1.1.146 +xref: MetaCyc:2.1.1.146-RXN +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0050631 +name: corydaline synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+." [EC:2.1.1.147, MetaCyc:2.1.1.147-RXN] +synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" EXACT [EC:2.1.1.147] +xref: EC:2.1.1.147 +xref: MetaCyc:2.1.1.147-RXN +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0050632 +name: propionyl-CoA C2-trimethyltridecanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.154, MetaCyc:2.3.1.154-RXN] +synonym: "3-oxopristanoyl-CoA hydrolase activity" EXACT [EC:2.3.1.154] +synonym: "3-oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154] +synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154] +synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154] +synonym: "oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154] +synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.154] +synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.154] +synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT [] +synonym: "SCPx" RELATED [EC:2.3.1.154] +synonym: "sterol carrier protein" RELATED [EC:2.3.1.154] +xref: EC:2.3.1.154 +xref: MetaCyc:2.3.1.154-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050633 +name: acetyl-CoA C-myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN] +synonym: "3-oxopalmitoyl-CoA hydrolase activity" EXACT [EC:2.3.1.155] +synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" EXACT [EC:2.3.1.155] +synonym: "myristoyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.155] +synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" EXACT [EC:2.3.1.155] +xref: EC:2.3.1.155 +xref: MetaCyc:2.3.1.155-RXN +is_a: GO:0016408 ! C-acyltransferase activity +is_a: GO:0019107 ! myristoyltransferase activity + +[Term] +id: GO:0050634 +name: phloroisovalerophenone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN] +synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" EXACT [EC:2.3.1.156] +synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" EXACT [EC:2.3.1.156] +synonym: "valerophenone synthase activity" EXACT [EC:2.3.1.156] +xref: EC:2.3.1.156 +xref: MetaCyc:2.3.1.156-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050635 +name: acridone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2." [EC:2.3.1.159, MetaCyc:2.3.1.159-RXN] +synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.159] +xref: EC:2.3.1.159 +xref: MetaCyc:2.3.1.159-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050636 +name: vinorine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 16-epivellosimine = CoA + vinorine." [EC:2.3.1.160, MetaCyc:2.3.1.160-RXN] +synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" EXACT [EC:2.3.1.160] +xref: EC:2.3.1.160 +xref: MetaCyc:2.3.1.160-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050637 +name: lovastatin nonaketide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O." [EC:2.3.1.161, MetaCyc:2.3.1.161-RXN] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" EXACT [EC:2.3.1.161] +xref: EC:2.3.1.161 +xref: MetaCyc:2.3.1.161-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050638 +name: taxadien-5-alpha-ol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5-alpha-ol = CoA + taxa-4(20),11-dien-5-alpha-yl acetate." [EC:2.3.1.162, MetaCyc:2.3.1.162-RXN] +synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] +synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162] +synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] +synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" EXACT [EC:2.3.1.162] +synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT [] +synonym: "taxadien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162] +synonym: "taxadienol acetyltransferase activity" EXACT [EC:2.3.1.162] +xref: EC:2.3.1.162 +xref: MetaCyc:2.3.1.162-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050639 +name: 10-hydroxytaxane O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C." [EC:2.3.1.163, MetaCyc:2.3.1.163-RXN] +synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] +synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163] +synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163] +xref: EC:2.3.1.163 +xref: MetaCyc:2.3.1.163-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050640 +name: isopenicillin-N N-acyltransferase activity +namespace: molecular_function +alt_id: GO:0042319 +alt_id: GO:0045440 +def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin-N + H2O = CoA + penicillin-G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN] +synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" EXACT [EC:2.3.1.164] +synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" EXACT [EC:2.3.1.164] +synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" EXACT [EC:2.3.1.164] +synonym: "isopenicillin N:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.164] +synonym: "isopenicillin-N acyltransferase activity" EXACT [] +xref: EC:2.3.1.164 +xref: MetaCyc:2.3.1.164-RXN +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0050641 +name: 6-methylsalicylic acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+." [EC:2.3.1.165, MetaCyc:2.3.1.165-RXN] +synonym: "6-MSAS activity" EXACT [EC:2.3.1.165] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" EXACT [EC:2.3.1.165] +synonym: "MSAS activity" EXACT [EC:2.3.1.165] +xref: EC:2.3.1.165 +xref: MetaCyc:2.3.1.165-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050642 +name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III." [EC:2.3.1.166, MetaCyc:2.3.1.166-RXN] +synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" EXACT [EC:2.3.1.166] +synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [] +synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] +synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" EXACT [EC:2.3.1.166] +synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] +synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166] +xref: EC:2.3.1.166 +xref: MetaCyc:2.3.1.166-RXN +is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups + +[Term] +id: GO:0050643 +name: 10-deacetylbaccatin III 10-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III." [EC:2.3.1.167, MetaCyc:2.3.1.167-RXN] +synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167] +xref: EC:2.3.1.167 +xref: MetaCyc:2.3.1.167-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050644 +name: cis-p-coumarate glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-p-coumarate + UDP-D-glucose = UDP + 4'-O-beta-D-glucosyl-cis-p-coumarate." [EC:2.4.1.209, MetaCyc:2.4.1.209-RXN] +synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.209] +xref: EC:2.4.1.209 +xref: MetaCyc:2.4.1.209-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050645 +name: limonoid glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210] +synonym: "LGTase activity" EXACT [EC:2.4.1.210] +synonym: "limonoid UDP-glucosyltransferase activity" EXACT [EC:2.4.1.210] +synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" EXACT [EC:2.4.1.210] +xref: EC:2.4.1.210 +xref: MetaCyc:2.4.1.210-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050646 +name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding +namespace: molecular_function +def: "Interacting selectively with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] +synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] +is_a: GO:0050543 ! icosatetraenoic acid binding + +[Term] +id: GO:0050647 +name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding +namespace: molecular_function +def: "Interacting selectively with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] +synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] +is_a: GO:0050543 ! icosatetraenoic acid binding + +[Term] +id: GO:0050648 +name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding +namespace: molecular_function +def: "Interacting selectively with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] +synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] +is_a: GO:0050543 ! icosatetraenoic acid binding + +[Term] +id: GO:0050649 +name: testosterone 6-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664] +synonym: "testosterone 6b-hydroxylase activity" EXACT [] +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0050650 +name: chondroitin sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] +subset: gosubset_prok +synonym: "chondroitin sulfate proteoglycan anabolism" EXACT [] +synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT [] +synonym: "chondroitin sulfate proteoglycan formation" EXACT [] +synonym: "chondroitin sulfate proteoglycan synthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT [] +is_a: GO:0030166 ! proteoglycan biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process + +[Term] +id: GO:0050651 +name: dermatan sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] +subset: gosubset_prok +synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT [] +synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT [] +synonym: "dermatan sulfate proteoglycan anabolism" EXACT [] +synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT [] +synonym: "dermatan sulfate proteoglycan formation" EXACT [] +synonym: "dermatan sulfate proteoglycan synthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT [] +is_a: GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process +is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process + +[Term] +id: GO:0050652 +name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process +namespace: biological_process +def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602] +subset: gosubset_prok +synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT [] +synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] +synonym: "dermatan sulfate proteoglycan chain elongation" EXACT [] +synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] +synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] +synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0050653 +name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process +namespace: biological_process +def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602] +subset: gosubset_prok +synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] +synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT [] +synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] +synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] +synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0050654 +name: chondroitin sulfate proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] +subset: gosubset_prok +synonym: "chondroitin sulfate proteoglycan metabolism" EXACT [] +synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT [] +synonym: "chondroitin sulphate proteoglycan metabolism" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0050655 +name: dermatan sulfate proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] +subset: gosubset_prok +synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT [] +synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT [] +synonym: "dermatan sulfate proteoglycan metabolism" EXACT [] +synonym: "dermatan sulphate proteoglycan metabolic process" EXACT [] +synonym: "dermatan sulphate proteoglycan metabolism" EXACT [] +is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process + +[Term] +id: GO:0050656 +name: 3'-phosphoadenosine 5'-phosphosulfate binding +namespace: molecular_function +def: "Interacting selectively with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai] +synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate binding" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT [] +synonym: "PAPS binding" EXACT [] +synonym: "phosphoadenosine phosphosulfate binding" EXACT [] +is_a: GO:0030554 ! adenyl nucleotide binding + +[Term] +id: GO:0050657 +name: nucleic acid transport +namespace: biological_process +def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of, within or between cells." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport + +[Term] +id: GO:0050658 +name: RNA transport +namespace: biological_process +def: "The directed movement of RNA, ribonucleic acids, into, out of, within or between cells." [GOC:ai] +is_a: GO:0050657 ! nucleic acid transport +is_a: GO:0051236 ! establishment of RNA localization + +[Term] +id: GO:0050659 +name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33] +synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" EXACT [EC:2.8.2.33] +synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33] +synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" EXACT [EC:2.8.2.33] +xref: EC:2.8.2.33 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050660 +name: FAD binding +namespace: molecular_function +def: "Interacting selectively with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "flavin adenine dinucleotide binding" EXACT [] +synonym: "flavine-adenine dinucleotide binding" EXACT [] +is_a: GO:0030554 ! adenyl nucleotide binding +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0050661 +name: NADP binding +namespace: molecular_function +def: "Interacting selectively with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH." [GOC:ai] +synonym: "NADP (oxidized) binding" EXACT [] +synonym: "NADP (reduced) binding" EXACT [] +synonym: "NADPH binding" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT [] +synonym: "oxidized NADP binding" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [] +synonym: "reduced NADP binding" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [] +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0050662 +name: coenzyme binding +namespace: molecular_function +def: "Interacting selectively with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0048037 ! cofactor binding + +[Term] +id: GO:0050663 +name: cytokine secretion +namespace: biological_process +def: "The regulated release of cytokines from a cell or group of cells. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] +is_a: GO:0009306 ! protein secretion +relationship: part_of GO:0001816 ! cytokine production + +[Term] +id: GO:0050664 +name: oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-] +xref: EC:1.6.3 +is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH + +[Term] +id: GO:0050665 +name: hydrogen peroxide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai] +subset: gosubset_prok +synonym: "hydrogen peroxide anabolism" EXACT [] +synonym: "hydrogen peroxide biosynthesis" EXACT [] +synonym: "hydrogen peroxide formation" EXACT [] +synonym: "hydrogen peroxide generation" EXACT [] +synonym: "hydrogen peroxide synthesis" EXACT [] +is_a: GO:0042743 ! hydrogen peroxide metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0050666 +name: regulation of homocysteine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of Hcy metabolic process" EXACT [] +synonym: "regulation of Hcy metabolism" EXACT [] +synonym: "regulation of homocysteine metabolism" EXACT [] +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +relationship: regulates GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0050667 +name: homocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "Hcy metabolic process" EXACT [] +synonym: "Hcy metabolism" EXACT [] +synonym: "homocysteine metabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0050668 +name: positive regulation of homocysteine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] +subset: gosubset_prok +synonym: "activation of homocysteine metabolic process" NARROW [] +synonym: "positive regulation of Hcy metabolic process" EXACT [] +synonym: "positive regulation of Hcy metabolism" EXACT [] +synonym: "positive regulation of homocysteine metabolism" EXACT [] +synonym: "stimulation of homocysteine metabolic process" NARROW [] +synonym: "up regulation of homocysteine metabolic process" EXACT [] +synonym: "up-regulation of homocysteine metabolic process" EXACT [] +synonym: "upregulation of homocysteine metabolic process" EXACT [] +is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process +is_a: GO:0050666 ! regulation of homocysteine metabolic process +relationship: positively_regulates GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0050669 +name: negative regulation of homocysteine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of homocysteine metabolic process" EXACT [] +synonym: "down-regulation of homocysteine metabolic process" EXACT [] +synonym: "downregulation of homocysteine metabolic process" EXACT [] +synonym: "inhibition of homocysteine metabolic process" NARROW [] +synonym: "negative regulation of Hcy metabolic process" EXACT [] +synonym: "negative regulation of Hcy metabolism" EXACT [] +synonym: "negative regulation of homocysteine metabolism" EXACT [] +is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process +is_a: GO:0050666 ! regulation of homocysteine metabolic process +relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0050670 +name: regulation of lymphocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai] +is_a: GO:0032944 ! regulation of mononuclear cell proliferation +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0050671 +name: positive regulation of lymphocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai] +synonym: "activation of lymphocyte proliferation" NARROW [] +synonym: "stimulation of lymphocyte proliferation" NARROW [] +synonym: "up regulation of lymphocyte proliferation" EXACT [] +synonym: "up-regulation of lymphocyte proliferation" EXACT [] +synonym: "upregulation of lymphocyte proliferation" EXACT [] +is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0050672 +name: negative regulation of lymphocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai] +synonym: "down regulation of lymphocyte proliferation" EXACT [] +synonym: "down-regulation of lymphocyte proliferation" EXACT [] +synonym: "downregulation of lymphocyte proliferation" EXACT [] +synonym: "inhibition of lymphocyte proliferation" NARROW [] +is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0050673 +name: epithelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0050674 +name: urothelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050675 +name: regulation of urothelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0050674 ! urothelial cell proliferation + +[Term] +id: GO:0050676 +name: negative regulation of urothelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai] +synonym: "down regulation of urothelial cell proliferation" EXACT [] +synonym: "down-regulation of urothelial cell proliferation" EXACT [] +synonym: "downregulation of urothelial cell proliferation" EXACT [] +synonym: "inhibition of urothelial cell proliferation" NARROW [] +is_a: GO:0050675 ! regulation of urothelial cell proliferation +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation + +[Term] +id: GO:0050677 +name: positive regulation of urothelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai] +synonym: "activation of urothelial cell proliferation" NARROW [] +synonym: "stimulation of urothelial cell proliferation" NARROW [] +synonym: "up regulation of urothelial cell proliferation" EXACT [] +synonym: "up-regulation of urothelial cell proliferation" EXACT [] +synonym: "upregulation of urothelial cell proliferation" EXACT [] +is_a: GO:0050675 ! regulation of urothelial cell proliferation +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: positively_regulates GO:0050674 ! urothelial cell proliferation + +[Term] +id: GO:0050678 +name: regulation of epithelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050679 +name: positive regulation of epithelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] +synonym: "activation of epithelial cell proliferation" NARROW [] +synonym: "stimulation of epithelial cell proliferation" NARROW [] +synonym: "up regulation of epithelial cell proliferation" EXACT [] +synonym: "up-regulation of epithelial cell proliferation" EXACT [] +synonym: "upregulation of epithelial cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: positively_regulates GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050680 +name: negative regulation of epithelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] +synonym: "down regulation of epithelial cell proliferation" EXACT [] +synonym: "down-regulation of epithelial cell proliferation" EXACT [] +synonym: "downregulation of epithelial cell proliferation" EXACT [] +synonym: "inhibition of epithelial cell proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050681 +name: androgen receptor binding +namespace: molecular_function +def: "Interacting selectively with an androgen receptor." [GOC:ai] +synonym: "AR binding" EXACT [] +is_a: GO:0035258 ! steroid hormone receptor binding + +[Term] +id: GO:0050682 +name: AF-2 domain binding +namespace: molecular_function +def: "Interacting selectively with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050683 +name: AF-1 domain binding +namespace: molecular_function +def: "Interacting selectively with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050684 +name: regulation of mRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] +subset: gosubset_prok +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0006397 ! mRNA processing + +[Term] +id: GO:0050685 +name: positive regulation of mRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai] +subset: gosubset_prok +synonym: "activation of mRNA processing" NARROW [] +synonym: "stimulation of mRNA processing" NARROW [] +synonym: "up regulation of mRNA processing" EXACT [] +synonym: "up-regulation of mRNA processing" EXACT [] +synonym: "upregulation of mRNA processing" EXACT [] +is_a: GO:0050684 ! regulation of mRNA processing +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0006397 ! mRNA processing + +[Term] +id: GO:0050686 +name: negative regulation of mRNA processing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA processing." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of mRNA processing" EXACT [] +synonym: "down-regulation of mRNA processing" EXACT [] +synonym: "downregulation of mRNA processing" EXACT [] +synonym: "inhibition of mRNA processing" NARROW [] +is_a: GO:0050684 ! regulation of mRNA processing +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0006397 ! mRNA processing + +[Term] +id: GO:0050687 +name: negative regulation of defense response to virus +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai] +synonym: "down regulation of antiviral response" EXACT [] +synonym: "down-regulation of antiviral response" EXACT [] +synonym: "downregulation of antiviral response" EXACT [] +synonym: "inhibition of antiviral response" NARROW [] +synonym: "negative regulation of antiviral response" EXACT [GOC:dph] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0050688 ! regulation of defense response to virus +relationship: negatively_regulates GO:0051607 ! defense response to virus + +[Term] +id: GO:0050688 +name: regulation of defense response to virus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai] +synonym: "regulation of antiviral response" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0051607 ! defense response to virus + +[Term] +id: GO:0050689 +name: negative regulation of defense response to virus by host +namespace: biological_process +def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb] +synonym: "down regulation of antiviral response by host" EXACT [] +synonym: "down-regulation of antiviral response by host" EXACT [] +synonym: "downregulation of antiviral response by host" EXACT [] +synonym: "inhibition of antiviral response by host" NARROW [] +synonym: "negative regulation by host of antiviral response" EXACT [] +synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] +is_a: GO:0050687 ! negative regulation of defense response to virus +is_a: GO:0050691 ! regulation of defense response to virus by host + +[Term] +id: GO:0050690 +name: regulation of defense response to virus by virus +namespace: biological_process +def: "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph] +synonym: "regulation by virus of antiviral response" EXACT [] +synonym: "regulation of antiviral response by virus" EXACT [GOC:dph] +synonym: "viral regulation of antiviral response" EXACT [] +is_a: GO:0050688 ! regulation of defense response to virus + +[Term] +id: GO:0050691 +name: regulation of defense response to virus by host +namespace: biological_process +def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph] +synonym: "host regulation of antiviral response" EXACT [] +synonym: "regulation by host of antiviral response" EXACT [] +synonym: "regulation of antiviral response by host" RELATED [GOC:dph] +is_a: GO:0050688 ! regulation of defense response to virus + +[Term] +id: GO:0050692 +name: DBD domain binding +namespace: molecular_function +def: "Interacting selectively with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors." [PMID:9682036] +synonym: "DNA binding domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050693 +name: LBD domain binding +namespace: molecular_function +def: "Interacting selectively with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036] +synonym: "ligand binding domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050694 +name: galactose 3-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829] +synonym: "Gal-3-O-sulfotransferase activity" EXACT [] +synonym: "galactose 3-O-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050695 +name: benzoylformate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN] +subset: gosubset_prok +synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" EXACT [EC:4.1.1.7] +synonym: "benzoylformate carboxy-lyase activity" EXACT [EC:4.1.1.7] +synonym: "phenylglyoxylate decarboxylase activity" EXACT [] +xref: EC:4.1.1.7 +xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN +xref: UM-BBD_enzymeID:e0652 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050696 +name: trichloroethylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai] +subset: gosubset_prok +synonym: "trichloroethene catabolic process" EXACT [] +synonym: "trichloroethene catabolism" EXACT [] +synonym: "trichloroethylene breakdown" EXACT [] +synonym: "trichloroethylene catabolism" EXACT [] +synonym: "trichloroethylene degradation" EXACT [] +is_a: GO:0018979 ! trichloroethylene metabolic process +is_a: GO:0042206 ! halogenated hydrocarbon catabolic process + +[Term] +id: GO:0050697 +name: 1,1,2-trichloroethene reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271] +synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT [] +synonym: "TCE-reductive dehalogenase activity" EXACT [] +xref: MetaCyc:TCEREDCHLOR-RXN +xref: UM-BBD_enzymeID:e0271 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0050698 +name: proteoglycan sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai] +synonym: "proteoglycan sulfate transfer" RELATED [] +synonym: "proteoglycan sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050699 +name: WW domain binding +namespace: molecular_function +def: "Interacting selectively with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050700 +name: CARD domain binding +namespace: molecular_function +def: "Interacting selectively with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050701 +name: interleukin-1 secretion +namespace: biological_process +def: "The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "IL-1 secretion" EXACT [] +is_a: GO:0050663 ! cytokine secretion + +[Term] +id: GO:0050702 +name: interleukin-1 beta secretion +namespace: biological_process +def: "The regulated release of interleukin 1 beta from a cell or group of cells." [GOC:ai] +synonym: "IL-1b secretion" EXACT [] +is_a: GO:0050701 ! interleukin-1 secretion + +[Term] +id: GO:0050703 +name: interleukin-1 alpha secretion +namespace: biological_process +def: "The regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] +synonym: "IL-1a secretion" EXACT [] +is_a: GO:0050701 ! interleukin-1 secretion + +[Term] +id: GO:0050704 +name: regulation of interleukin-1 secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai] +is_a: GO:0050707 ! regulation of cytokine secretion +relationship: regulates GO:0050701 ! interleukin-1 secretion + +[Term] +id: GO:0050705 +name: regulation of interleukin-1 alpha secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] +is_a: GO:0050704 ! regulation of interleukin-1 secretion +relationship: regulates GO:0050703 ! interleukin-1 alpha secretion + +[Term] +id: GO:0050706 +name: regulation of interleukin-1 beta secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai] +is_a: GO:0050704 ! regulation of interleukin-1 secretion +relationship: regulates GO:0050702 ! interleukin-1 beta secretion + +[Term] +id: GO:0050707 +name: regulation of cytokine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0050663 ! cytokine secretion + +[Term] +id: GO:0050708 +name: regulation of protein secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a protein from a cell or group of cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0009306 ! protein secretion + +[Term] +id: GO:0050709 +name: negative regulation of protein secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a protein from a cell or group of cells." [GOC:ai] +synonym: "down regulation of protein secretion" EXACT [] +synonym: "down-regulation of protein secretion" EXACT [] +synonym: "downregulation of protein secretion" EXACT [] +synonym: "inhibition of protein secretion" NARROW [] +is_a: GO:0050708 ! regulation of protein secretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051224 ! negative regulation of protein transport +relationship: negatively_regulates GO:0009306 ! protein secretion + +[Term] +id: GO:0050710 +name: negative regulation of cytokine secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai] +synonym: "down regulation of cytokine secretion" EXACT [] +synonym: "down-regulation of cytokine secretion" EXACT [] +synonym: "downregulation of cytokine secretion" EXACT [] +synonym: "inhibition of cytokine secretion" NARROW [] +is_a: GO:0050707 ! regulation of cytokine secretion +is_a: GO:0050709 ! negative regulation of protein secretion +relationship: negatively_regulates GO:0050663 ! cytokine secretion + +[Term] +id: GO:0050711 +name: negative regulation of interleukin-1 secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai] +synonym: "down regulation of interleukin-1 secretion" EXACT [] +synonym: "down-regulation of interleukin-1 secretion" EXACT [] +synonym: "downregulation of interleukin-1 secretion" EXACT [] +synonym: "inhibition of interleukin-1 secretion" NARROW [] +is_a: GO:0050704 ! regulation of interleukin-1 secretion +is_a: GO:0050710 ! negative regulation of cytokine secretion +relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion + +[Term] +id: GO:0050712 +name: negative regulation of interleukin-1 alpha secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] +synonym: "down regulation of interleukin-1 alpha secretion" EXACT [] +synonym: "down-regulation of interleukin-1 alpha secretion" EXACT [] +synonym: "downregulation of interleukin-1 alpha secretion" EXACT [] +synonym: "inhibition of interleukin-1 alpha secretion" NARROW [] +is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion +is_a: GO:0050711 ! negative regulation of interleukin-1 secretion +relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion + +[Term] +id: GO:0050713 +name: negative regulation of interleukin-1 beta secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai] +synonym: "down regulation of interleukin-1 beta secretion" EXACT [] +synonym: "down-regulation of interleukin-1 beta secretion" EXACT [] +synonym: "downregulation of interleukin-1 beta secretion" EXACT [] +synonym: "inhibition of interleukin-1 beta secretion" NARROW [] +is_a: GO:0050706 ! regulation of interleukin-1 beta secretion +is_a: GO:0050711 ! negative regulation of interleukin-1 secretion +relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion + +[Term] +id: GO:0050714 +name: positive regulation of protein secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a protein from a cell or group of cells." [GOC:ai] +synonym: "activation of protein secretion" NARROW [] +synonym: "stimulation of protein secretion" NARROW [] +synonym: "up regulation of protein secretion" EXACT [] +synonym: "up-regulation of protein secretion" EXACT [] +synonym: "upregulation of protein secretion" EXACT [] +is_a: GO:0050708 ! regulation of protein secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051222 ! positive regulation of protein transport +relationship: positively_regulates GO:0009306 ! protein secretion + +[Term] +id: GO:0050715 +name: positive regulation of cytokine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai] +synonym: "activation of cytokine secretion" NARROW [] +synonym: "stimulation of cytokine secretion" NARROW [] +synonym: "up regulation of cytokine secretion" EXACT [] +synonym: "up-regulation of cytokine secretion" EXACT [] +synonym: "upregulation of cytokine secretion" EXACT [] +is_a: GO:0050707 ! regulation of cytokine secretion +is_a: GO:0050714 ! positive regulation of protein secretion +relationship: positively_regulates GO:0050663 ! cytokine secretion + +[Term] +id: GO:0050716 +name: positive regulation of interleukin-1 secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai] +synonym: "activation of interleukin-1 secretion" NARROW [] +synonym: "stimulation of interleukin-1 secretion" NARROW [] +synonym: "up regulation of interleukin-1 secretion" EXACT [] +synonym: "up-regulation of interleukin-1 secretion" EXACT [] +synonym: "upregulation of interleukin-1 secretion" EXACT [] +is_a: GO:0050704 ! regulation of interleukin-1 secretion +is_a: GO:0050715 ! positive regulation of cytokine secretion +relationship: positively_regulates GO:0050701 ! interleukin-1 secretion + +[Term] +id: GO:0050717 +name: positive regulation of interleukin-1 alpha secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai] +synonym: "activation of interleukin-1 alpha secretion" NARROW [] +synonym: "stimulation of interleukin-1 alpha secretion" NARROW [] +synonym: "up regulation of interleukin-1 alpha secretion" EXACT [] +synonym: "up-regulation of interleukin-1 alpha secretion" EXACT [] +synonym: "upregulation of interleukin-1 alpha secretion" EXACT [] +is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion +is_a: GO:0050716 ! positive regulation of interleukin-1 secretion +relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion + +[Term] +id: GO:0050718 +name: positive regulation of interleukin-1 beta secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai] +synonym: "activation of interleukin-1 beta secretion" NARROW [] +synonym: "stimulation of interleukin-1 beta secretion" NARROW [] +synonym: "up regulation of interleukin-1 beta secretion" EXACT [] +synonym: "up-regulation of interleukin-1 beta secretion" EXACT [] +synonym: "upregulation of interleukin-1 beta secretion" EXACT [] +is_a: GO:0050706 ! regulation of interleukin-1 beta secretion +is_a: GO:0050716 ! positive regulation of interleukin-1 secretion +relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion + +[Term] +id: GO:0050719 +name: interleukin-1 alpha biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] +synonym: "interleukin-1 alpha anabolism" EXACT [] +synonym: "interleukin-1 alpha biosynthesis" EXACT [] +synonym: "interleukin-1 alpha formation" EXACT [] +synonym: "interleukin-1 alpha synthesis" EXACT [] +is_a: GO:0042222 ! interleukin-1 biosynthetic process +relationship: part_of GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0050720 +name: interleukin-1 beta biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] +synonym: "interleukin-1 beta anabolism" EXACT [] +synonym: "interleukin-1 beta biosynthesis" EXACT [] +synonym: "interleukin-1 beta formation" EXACT [] +synonym: "interleukin-1 beta synthesis" EXACT [] +is_a: GO:0042222 ! interleukin-1 biosynthetic process +relationship: part_of GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0050721 +name: regulation of interleukin-1 alpha biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] +synonym: "regulation of interleukin-1 alpha anabolism" EXACT [] +synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT [] +synonym: "regulation of interleukin-1 alpha formation" EXACT [] +synonym: "regulation of interleukin-1 alpha synthesis" EXACT [] +is_a: GO:0032650 ! regulation of interleukin-1 alpha production +is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process +relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process + +[Term] +id: GO:0050722 +name: regulation of interleukin-1 beta biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] +synonym: "regulation of interleukin-1 beta anabolism" EXACT [] +synonym: "regulation of interleukin-1 beta biosynthesis" EXACT [] +synonym: "regulation of interleukin-1 beta formation" EXACT [] +synonym: "regulation of interleukin-1 beta synthesis" EXACT [] +is_a: GO:0032651 ! regulation of interleukin-1 beta production +is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process +relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process + +[Term] +id: GO:0050723 +name: negative regulation of interleukin-1 alpha biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] +synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT [] +synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-1 alpha formation" EXACT [] +synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT [] +is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process +is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process +relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process + +[Term] +id: GO:0050724 +name: negative regulation of interleukin-1 beta biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] +synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT [] +synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT [] +synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT [] +synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 beta anabolism" EXACT [] +synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT [] +synonym: "negative regulation of interleukin-1 beta formation" EXACT [] +synonym: "negative regulation of interleukin-1 beta synthesis" EXACT [] +is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process +is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process +relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process + +[Term] +id: GO:0050725 +name: positive regulation of interleukin-1 beta biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai] +synonym: "activation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 beta anabolism" EXACT [] +synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-1 beta formation" EXACT [] +synonym: "positive regulation of interleukin-1 beta synthesis" EXACT [] +synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT [] +is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process +is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process +relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process + +[Term] +id: GO:0050726 +name: positive regulation of interleukin-1 alpha biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai] +synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT [] +synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT [] +synonym: "positive regulation of interleukin-1 alpha formation" EXACT [] +synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT [] +synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT [] +synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT [] +synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT [] +is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process +is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process +relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process + +[Term] +id: GO:0050727 +name: regulation of inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0006954 ! inflammatory response + +[Term] +id: GO:0050728 +name: negative regulation of inflammatory response +namespace: biological_process +alt_id: GO:0030236 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] +synonym: "anti-inflammatory response" EXACT [] +synonym: "down regulation of inflammatory response" EXACT [] +synonym: "down-regulation of inflammatory response" EXACT [] +synonym: "downregulation of inflammatory response" EXACT [] +synonym: "inhibition of inflammatory response" NARROW [] +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0050727 ! regulation of inflammatory response +relationship: negatively_regulates GO:0006954 ! inflammatory response + +[Term] +id: GO:0050729 +name: positive regulation of inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] +synonym: "activation of inflammatory response" NARROW [] +synonym: "stimulation of inflammatory response" NARROW [] +synonym: "up regulation of inflammatory response" EXACT [] +synonym: "up-regulation of inflammatory response" EXACT [] +synonym: "upregulation of inflammatory response" EXACT [] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0050727 ! regulation of inflammatory response +relationship: positively_regulates GO:0006954 ! inflammatory response + +[Term] +id: GO:0050730 +name: regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +subset: gosubset_prok +is_a: GO:0001932 ! regulation of protein amino acid phosphorylation +relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050731 +name: positive regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +subset: gosubset_prok +synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW [] +synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW [] +synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT [] +is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050732 +name: negative regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW [] +is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050733 +name: RS domain binding +namespace: molecular_function +def: "Interacting selectively with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050734 +name: hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai] +is_a: GO:0008415 ! acyltransferase activity + +[Term] +id: GO:0050735 +name: N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0016420 ! malonyltransferase activity + +[Term] +id: GO:0050736 +name: O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016420 ! malonyltransferase activity + +[Term] +id: GO:0050737 +name: O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0050734 ! hydroxycinnamoyltransferase activity + +[Term] +id: GO:0050738 +name: fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0050739 +name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium +namespace: biological_process +def: "The posttranslational cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348] +subset: gosubset_prok +xref: RESID:AA0348 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0018211 ! peptidyl-tryptophan modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0050740 +name: protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine +namespace: biological_process +def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349] +subset: gosubset_prok +xref: RESID:AA0349 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050741 +name: protein-FMN linkage via O3-riboflavin phosphoryl-L-serine +namespace: biological_process +def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350] +subset: gosubset_prok +xref: RESID:AA0350 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050742 +name: protein-FMN linkage via S-(4a-FMN)-L-cysteine +namespace: biological_process +def: "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351] +subset: gosubset_prok +xref: RESID:AA0351 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050743 +name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine +namespace: biological_process +def: "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352] +subset: gosubset_prok +xref: RESID:AA0352 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050744 +name: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine +namespace: biological_process +def: "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353] +subset: gosubset_prok +xref: RESID:AA0353 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050745 +name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188] +subset: gosubset_prok +xref: RESID:AA0188 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine + +[Term] +id: GO:0050746 +name: regulation of lipoprotein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of lipoprotein metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0050747 +name: positive regulation of lipoprotein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:ai] +subset: gosubset_prok +synonym: "activation of lipoprotein metabolic process" NARROW [] +synonym: "positive regulation of lipoprotein metabolism" EXACT [] +synonym: "stimulation of lipoprotein metabolic process" NARROW [] +synonym: "up regulation of lipoprotein metabolic process" EXACT [] +synonym: "up-regulation of lipoprotein metabolic process" EXACT [] +synonym: "upregulation of lipoprotein metabolic process" EXACT [] +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0050748 +name: negative regulation of lipoprotein metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of lipoprotein metabolic process" EXACT [] +synonym: "down-regulation of lipoprotein metabolic process" EXACT [] +synonym: "downregulation of lipoprotein metabolic process" EXACT [] +synonym: "inhibition of lipoprotein metabolic process" NARROW [] +synonym: "negative regulation of lipoprotein metabolism" EXACT [] +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0050749 +name: apolipoprotein E receptor binding +namespace: molecular_function +def: "Interacting selectively with an apolipoprotein E receptor." [GOC:ai] +is_a: GO:0034190 ! apolipoprotein receptor binding +is_a: GO:0050750 ! low-density lipoprotein receptor binding + +[Term] +id: GO:0050750 +name: low-density lipoprotein receptor binding +namespace: molecular_function +def: "Interacting selectively with a low density lipoprotein receptor." [GOC:ai] +synonym: "LDL receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0050751 +name: fractalkine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] +synonym: "ABCD-3 biosynthesis" EXACT [] +synonym: "ABCD-3 biosynthetic process" EXACT [] +synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT [] +synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT [] +synonym: "CX3CL1 biosynthesis" EXACT [] +synonym: "CX3CL1 biosynthetic process" EXACT [] +synonym: "fractalkine anabolism" EXACT [] +synonym: "fractalkine biosynthesis" EXACT [] +synonym: "fractalkine formation" EXACT [] +synonym: "fractalkine synthesis" EXACT [] +synonym: "neurotactin biosynthesis" EXACT [] +synonym: "neurotactin biosynthetic process" EXACT [] +is_a: GO:0042033 ! chemokine biosynthetic process +is_a: GO:0050756 ! fractalkine metabolic process +relationship: part_of GO:0032603 ! fractalkine production + +[Term] +id: GO:0050752 +name: regulation of fractalkine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] +synonym: "regulation of CX3CL1 biosynthesis" EXACT [] +synonym: "regulation of CX3CL1 biosynthetic process" EXACT [] +synonym: "regulation of fractalkine anabolism" EXACT [] +synonym: "regulation of fractalkine biosynthesis" EXACT [] +synonym: "regulation of fractalkine formation" EXACT [] +synonym: "regulation of fractalkine synthesis" EXACT [] +synonym: "regulation of neurotactin biosynthesis" EXACT [] +synonym: "regulation of neurotactin biosynthetic process" EXACT [] +is_a: GO:0032644 ! regulation of fractalkine production +is_a: GO:0045073 ! regulation of chemokine biosynthetic process +relationship: regulates GO:0050751 ! fractalkine biosynthetic process + +[Term] +id: GO:0050753 +name: negative regulation of fractalkine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] +synonym: "down regulation of fractalkine biosynthetic process" EXACT [] +synonym: "down-regulation of fractalkine biosynthetic process" EXACT [] +synonym: "downregulation of fractalkine biosynthetic process" EXACT [] +synonym: "inhibition of fractalkine biosynthetic process" NARROW [] +synonym: "negative regulation of CX3CL1 biosynthesis" EXACT [] +synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT [] +synonym: "negative regulation of fractalkine anabolism" EXACT [] +synonym: "negative regulation of fractalkine biosynthesis" EXACT [] +synonym: "negative regulation of fractalkine formation" EXACT [] +synonym: "negative regulation of fractalkine synthesis" EXACT [] +synonym: "negative regulation of neurotactin biosynthesis" EXACT [] +synonym: "negative regulation of neurotactin biosynthetic process" EXACT [] +is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process +is_a: GO:0050752 ! regulation of fractalkine biosynthetic process +relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process + +[Term] +id: GO:0050754 +name: positive regulation of fractalkine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de] +synonym: "activation of fractalkine biosynthetic process" NARROW [] +synonym: "positive regulation of CX3CL1 biosynthesis" EXACT [] +synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT [] +synonym: "positive regulation of fractalkine anabolism" EXACT [] +synonym: "positive regulation of fractalkine biosynthesis" EXACT [] +synonym: "positive regulation of fractalkine formation" EXACT [] +synonym: "positive regulation of fractalkine synthesis" EXACT [] +synonym: "positive regulation of neurotactin biosynthesis" EXACT [] +synonym: "positive regulation of neurotactin biosynthetic process" EXACT [] +synonym: "stimulation of fractalkine biosynthetic process" NARROW [] +synonym: "up regulation of fractalkine biosynthetic process" EXACT [] +synonym: "up-regulation of fractalkine biosynthetic process" EXACT [] +synonym: "upregulation of fractalkine biosynthetic process" EXACT [] +is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process +is_a: GO:0050752 ! regulation of fractalkine biosynthetic process +relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process + +[Term] +id: GO:0050755 +name: chemokine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "chemokine metabolism" EXACT [] +is_a: GO:0042107 ! cytokine metabolic process + +[Term] +id: GO:0050756 +name: fractalkine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de] +synonym: "ABCD-3 metabolic process" EXACT [] +synonym: "ABCD-3 metabolism" EXACT [] +synonym: "CX3C membrane-anchored chemokine metabolic process" EXACT [] +synonym: "CX3C membrane-anchored chemokine metabolism" EXACT [] +synonym: "CX3CL1 metabolic process" EXACT [] +synonym: "CX3CL1 metabolism" EXACT [] +synonym: "fractalkine metabolism" EXACT [] +synonym: "neurotactin metabolic process" EXACT [] +synonym: "neurotactin metabolism" EXACT [] +is_a: GO:0050755 ! chemokine metabolic process + +[Term] +id: GO:0050757 +name: thymidylate synthase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45] +subset: gosubset_prok +synonym: "thymidylate synthase anabolism" EXACT [] +synonym: "thymidylate synthase biosynthesis" EXACT [] +synonym: "thymidylate synthase formation" EXACT [] +synonym: "thymidylate synthase synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0050758 +name: regulation of thymidylate synthase biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of thymidylate synthase anabolism" EXACT [] +synonym: "regulation of thymidylate synthase biosynthesis" EXACT [] +synonym: "regulation of thymidylate synthase formation" EXACT [] +synonym: "regulation of thymidylate synthase synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0050757 ! thymidylate synthase biosynthetic process + +[Term] +id: GO:0050759 +name: positive regulation of thymidylate synthase biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] +subset: gosubset_prok +synonym: "activation of thymidylate synthase biosynthetic process" NARROW [] +synonym: "positive regulation of thymidylate synthase anabolism" EXACT [] +synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT [] +synonym: "positive regulation of thymidylate synthase formation" EXACT [] +synonym: "positive regulation of thymidylate synthase synthesis" EXACT [] +synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW [] +synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process +relationship: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process + +[Term] +id: GO:0050760 +name: negative regulation of thymidylate synthase biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW [] +synonym: "negative regulation of thymidylate synthase anabolism" EXACT [] +synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT [] +synonym: "negative regulation of thymidylate synthase formation" EXACT [] +synonym: "negative regulation of thymidylate synthase synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process +relationship: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process + +[Term] +id: GO:0050761 +name: depsipeptide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +synonym: "depsipeptide metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0050762 +name: depsipeptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] +subset: gosubset_prok +synonym: "depsipeptide breakdown" EXACT [] +synonym: "depsipeptide catabolism" EXACT [] +synonym: "depsipeptide degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0050761 ! depsipeptide metabolic process + +[Term] +id: GO:0050763 +name: depsipeptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] +subset: gosubset_prok +synonym: "depsipeptide anabolism" EXACT [] +synonym: "depsipeptide biosynthesis" EXACT [] +synonym: "depsipeptide formation" EXACT [] +synonym: "depsipeptide synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0050761 ! depsipeptide metabolic process + +[Term] +id: GO:0050764 +name: regulation of phagocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process whereby phagocytes engulf external particulate material." [GOC:ai] +is_a: GO:0030100 ! regulation of endocytosis +relationship: regulates GO:0006909 ! phagocytosis + +[Term] +id: GO:0050765 +name: negative regulation of phagocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phagocytosis." [GOC:ai] +synonym: "down regulation of phagocytosis" EXACT [] +synonym: "down-regulation of phagocytosis" EXACT [] +synonym: "downregulation of phagocytosis" EXACT [] +synonym: "inhibition of phagocytosis" NARROW [] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0050764 ! regulation of phagocytosis +relationship: negatively_regulates GO:0006909 ! phagocytosis + +[Term] +id: GO:0050766 +name: positive regulation of phagocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai] +synonym: "activation of phagocytosis" NARROW [] +synonym: "stimulation of phagocytosis" NARROW [] +synonym: "up regulation of phagocytosis" EXACT [] +synonym: "up-regulation of phagocytosis" EXACT [] +synonym: "upregulation of phagocytosis" EXACT [] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0050764 ! regulation of phagocytosis +relationship: positively_regulates GO:0006909 ! phagocytosis + +[Term] +id: GO:0050767 +name: regulation of neurogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] +is_a: GO:0051960 ! regulation of nervous system development +relationship: part_of GO:0048699 ! generation of neurons +relationship: regulates GO:0022008 ! neurogenesis + +[Term] +id: GO:0050768 +name: negative regulation of neurogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] +synonym: "down regulation of neurogenesis" EXACT [] +synonym: "down-regulation of neurogenesis" EXACT [] +synonym: "downregulation of neurogenesis" EXACT [] +synonym: "inhibition of neurogenesis" NARROW [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0050767 ! regulation of neurogenesis +relationship: negatively_regulates GO:0022008 ! neurogenesis + +[Term] +id: GO:0050769 +name: positive regulation of neurogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai] +synonym: "activation of neurogenesis" NARROW [] +synonym: "stimulation of neurogenesis" NARROW [] +synonym: "up regulation of neurogenesis" EXACT [] +synonym: "up-regulation of neurogenesis" EXACT [] +synonym: "upregulation of neurogenesis" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0050767 ! regulation of neurogenesis +relationship: positively_regulates GO:0022008 ! neurogenesis + +[Term] +id: GO:0050770 +name: regulation of axonogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0007409 ! axonogenesis + +[Term] +id: GO:0050771 +name: negative regulation of axonogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] +synonym: "down regulation of axonogenesis" EXACT [] +synonym: "down-regulation of axonogenesis" EXACT [] +synonym: "downregulation of axonogenesis" EXACT [] +synonym: "inhibition of axonogenesis" NARROW [] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0050768 ! negative regulation of neurogenesis +is_a: GO:0050770 ! regulation of axonogenesis +relationship: negatively_regulates GO:0007409 ! axonogenesis + +[Term] +id: GO:0050772 +name: positive regulation of axonogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] +synonym: "activation of axonogenesis" NARROW [] +synonym: "stimulation of axonogenesis" NARROW [] +synonym: "up regulation of axonogenesis" EXACT [] +synonym: "up-regulation of axonogenesis" EXACT [] +synonym: "upregulation of axonogenesis" EXACT [] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0050769 ! positive regulation of neurogenesis +is_a: GO:0050770 ! regulation of axonogenesis +relationship: positively_regulates GO:0007409 ! axonogenesis + +[Term] +id: GO:0050773 +name: regulation of dendrite development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0016358 ! dendrite development + +[Term] +id: GO:0050774 +name: negative regulation of dendrite morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] +synonym: "down regulation of dendrite morphogenesis" EXACT [] +synonym: "down-regulation of dendrite morphogenesis" EXACT [] +synonym: "downregulation of dendrite morphogenesis" EXACT [] +synonym: "inhibition of dendrite morphogenesis" NARROW [] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0048814 ! regulation of dendrite morphogenesis +is_a: GO:0050768 ! negative regulation of neurogenesis +relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0050775 +name: positive regulation of dendrite morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] +synonym: "activation of dendrite morphogenesis" NARROW [] +synonym: "stimulation of dendrite morphogenesis" NARROW [] +synonym: "up regulation of dendrite morphogenesis" EXACT [] +synonym: "up-regulation of dendrite morphogenesis" EXACT [] +synonym: "upregulation of dendrite morphogenesis" EXACT [] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0048814 ! regulation of dendrite morphogenesis +is_a: GO:0050769 ! positive regulation of neurogenesis +relationship: positively_regulates GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0050776 +name: regulation of immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0006955 ! immune response + +[Term] +id: GO:0050777 +name: negative regulation of immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] +synonym: "down regulation of immune response" EXACT [] +synonym: "down-regulation of immune response" EXACT [] +synonym: "downregulation of immune response" EXACT [] +synonym: "inhibition of immune response" NARROW [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0050776 ! regulation of immune response +relationship: negatively_regulates GO:0006955 ! immune response + +[Term] +id: GO:0050778 +name: positive regulation of immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] +synonym: "stimulation of immune response" NARROW [] +synonym: "up regulation of immune response" EXACT [] +synonym: "up-regulation of immune response" EXACT [] +synonym: "upregulation of immune response" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0050776 ! regulation of immune response +relationship: positively_regulates GO:0006955 ! immune response + +[Term] +id: GO:0050779 +name: RNA destabilization +namespace: biological_process +def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] +subset: gosubset_prok +is_a: GO:0043487 ! regulation of RNA stability + +[Term] +id: GO:0050780 +name: dopamine receptor binding +namespace: molecular_function +def: "Interacting selectively with a dopamine receptor." [GOC:ai] +is_a: GO:0001664 ! G-protein-coupled receptor binding + +[Term] +id: GO:0050781 +name: ortho-trichlorophenol reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trichlorophenol +2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029] +subset: gosubset_prok +synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT [] +synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0050782 +name: galactose uniporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6] +synonym: "galactose, glucose uniporter activity" BROAD [] +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0008516 ! hexose uniporter activity + +[Term] +id: GO:0050783 +name: cocaine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cocaine metabolism" EXACT [] +is_a: GO:0017144 ! drug metabolic process + +[Term] +id: GO:0050784 +name: cocaine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cocaine breakdown" EXACT [] +synonym: "cocaine catabolism" EXACT [] +synonym: "cocaine degradation" EXACT [] +is_a: GO:0042737 ! drug catabolic process +is_a: GO:0050783 ! cocaine metabolic process + +[Term] +id: GO:0050785 +name: advanced glycation end-product receptor activity +namespace: molecular_function +def: "Combining with advanced glycation end-products to initiate a change in cell activity." [PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812] +synonym: "RAGE receptor activity" EXACT [] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0050786 +name: RAGE receptor binding +namespace: molecular_function +def: "Interacting selectively with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai] +synonym: "advanced glycation end-product receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0050787 +name: detoxification of mercury ion +namespace: biological_process +def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920] +subset: gosubset_prok +is_a: GO:0009636 ! response to toxin +is_a: GO:0046689 ! response to mercury ion + +[Term] +id: GO:0050788 +name: sequestering of mercury +namespace: biological_process +def: "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920] +synonym: "mercuric ion (Hg2+) sequestering" EXACT [] +synonym: "mercuric ion (Hg2+) sequestration" EXACT [] +synonym: "mercury (Hg) ion sequestering" EXACT [] +synonym: "mercury (Hg) ion sequestration" EXACT [] +synonym: "mercury (Hg2+) ion retention" EXACT [] +synonym: "mercury (Hg2+) ion storage" EXACT [] +synonym: "retention of mercury (Hg2+) ion" EXACT [] +synonym: "sequestering of mercuric ion (Hg2+)" EXACT [] +synonym: "sequestering of mercury (Hg) ion" EXACT [] +synonym: "sequestration of mercuric ion (Hg2+)" EXACT [] +synonym: "sequestration of mercury (Hg) ion" EXACT [] +synonym: "storage of mercury (Hg2+) ion" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +relationship: part_of GO:0050787 ! detoxification of mercury ion + +[Term] +id: GO:0050789 +name: regulation of biological process +namespace: biological_process +alt_id: GO:0050791 +def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] +subset: goslim_generic +subset: goslim_goa +subset: gosubset_prok +synonym: "regulation of physiological process" EXACT [] +is_a: GO:0065007 ! biological regulation +relationship: regulates GO:0008150 ! biological_process + +[Term] +id: GO:0050790 +name: regulation of catalytic activity +namespace: biological_process +def: "Any process that modulates the activity of an enzyme." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of enzyme activity" EXACT [] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0050792 +name: regulation of viral reproduction +namespace: biological_process +def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] +synonym: "regulation of viral life cycle" EXACT [GOC:tb] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0016032 ! viral reproduction + +[Term] +id: GO:0050793 +name: regulation of developmental process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0032502 ! developmental process + +[Term] +id: GO:0050794 +name: regulation of cellular process +namespace: biological_process +alt_id: GO:0051244 +def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of cellular physiological process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0009987 ! cellular process + +[Term] +id: GO:0050795 +name: regulation of behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:go_curators] +subset: gosubset_prok +synonym: "regulation of behaviour" EXACT [] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0007610 ! behavior + +[Term] +id: GO:0050796 +name: regulation of insulin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0030073 ! insulin secretion + +[Term] +id: GO:0050797 +name: thymidylate synthase (FAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + FADH2 = dTMP + tetrahydrofolate + FAD." [EC:2.1.1.148] +subset: gosubset_prok +synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.148] +synonym: "FDTS activity" EXACT [EC:2.1.1.148] +synonym: "flavin dependent thymidylate synthase activity" EXACT [EC:2.1.1.148] +synonym: "Thy1 activity" EXACT [] +synonym: "ThyX activity" EXACT [] +xref: EC:2.1.1.148 +is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0050798 +name: activated T cell proliferation +namespace: biological_process +def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph] +comment: Note that this term is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells. +synonym: "activated T lymphocyte proliferation" EXACT [] +synonym: "activated T-cell proliferation" EXACT [] +synonym: "activated T-lymphocyte proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0050799 +name: cocaine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai] +subset: gosubset_prok +synonym: "cocaine anabolism" EXACT [] +synonym: "cocaine biosynthesis" EXACT [] +synonym: "cocaine formation" EXACT [] +synonym: "cocaine synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0050783 ! cocaine metabolic process + +[Term] +id: GO:0050800 +name: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai] +comment: This term was made obsolete because it represents both process and function information. +is_obsolete: true +replaced_by: GO:0003924 +replaced_by: GO:0006810 + +[Term] +id: GO:0050801 +name: ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of ions within an organism or cell." [GOC:ai] +subset: gosubset_prok +synonym: "electrolyte homeostasis" RELATED [] +synonym: "negative regulation of crystal biosynthesis" RELATED [] +synonym: "negative regulation of crystal formation" RELATED [] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0050802 +name: circadian sleep/wake cycle, sleep +namespace: biological_process +def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] +is_a: GO:0022410 ! circadian sleep/wake cycle process + +[Term] +id: GO:0050803 +name: regulation of synapse structure and activity +namespace: biological_process +def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0007268 ! synaptic transmission + +[Term] +id: GO:0050804 +name: regulation of synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] +is_a: GO:0051969 ! regulation of transmission of nerve impulse +relationship: regulates GO:0007268 ! synaptic transmission + +[Term] +id: GO:0050805 +name: negative regulation of synaptic transmission +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] +synonym: "down regulation of synaptic transmission" EXACT [] +synonym: "down-regulation of synaptic transmission" EXACT [] +synonym: "downregulation of synaptic transmission" EXACT [] +synonym: "inhibition of synaptic transmission" NARROW [] +is_a: GO:0050804 ! regulation of synaptic transmission +is_a: GO:0051970 ! negative regulation of transmission of nerve impulse +relationship: negatively_regulates GO:0007268 ! synaptic transmission + +[Term] +id: GO:0050806 +name: positive regulation of synaptic transmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] +synonym: "activation of synaptic transmission" NARROW [] +synonym: "stimulation of synaptic transmission" NARROW [] +synonym: "up regulation of synaptic transmission" EXACT [] +synonym: "up-regulation of synaptic transmission" EXACT [] +synonym: "upregulation of synaptic transmission" EXACT [] +is_a: GO:0050804 ! regulation of synaptic transmission +is_a: GO:0051971 ! positive regulation of transmission of nerve impulse +relationship: positively_regulates GO:0007268 ! synaptic transmission + +[Term] +id: GO:0050807 +name: regulation of synapse organization +namespace: biological_process +def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] +synonym: "regulation of synapse organization and biogenesis" EXACT [] +synonym: "regulation of synapse structure" EXACT [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: part_of GO:0050803 ! regulation of synapse structure and activity +relationship: regulates GO:0050808 ! synapse organization + +[Term] +id: GO:0050808 +name: synapse organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] +synonym: "synapse development" EXACT [] +synonym: "synapse organisation and biogenesis" EXACT [] +synonym: "synapse organization and biogenesis" EXACT [] +is_a: GO:0043062 ! extracellular structure organization + +[Term] +id: GO:0050809 +name: diazepam binding +namespace: molecular_function +def: "Interacting selectively with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "diazepam binding inhibitor activity" RELATED [] +synonym: "Valium binding" EXACT [] +is_a: GO:0008144 ! drug binding + +[Term] +id: GO:0050810 +name: regulation of steroid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of steroid anabolism" EXACT [] +synonym: "regulation of steroid biosynthesis" EXACT [] +synonym: "regulation of steroid formation" EXACT [] +synonym: "regulation of steroid synthesis" EXACT [] +synonym: "regulation of steroidogenesis" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006694 ! steroid biosynthetic process + +[Term] +id: GO:0050811 +name: GABA receptor binding +namespace: molecular_function +def: "Interacting selectively with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] +synonym: "4-aminobutanoate receptor binding" EXACT [] +synonym: "4-aminobutyrate receptor binding" EXACT [] +synonym: "diazepam binding inhibitor activity" RELATED [] +synonym: "gamma-aminobutyric acid receptor binding" EXACT [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0050812 +name: regulation of acyl-CoA biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of acyl-CoA anabolism" EXACT [] +synonym: "regulation of acyl-CoA biosynthesis" EXACT [] +synonym: "regulation of acyl-CoA formation" EXACT [] +synonym: "regulation of acyl-CoA synthesis" EXACT [] +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: regulates GO:0046949 ! acyl-CoA biosynthetic process + +[Term] +id: GO:0050813 +name: epothilone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "epothilone metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0050814 +name: epothilone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai] +subset: gosubset_prok +synonym: "epothilone anabolism" EXACT [] +synonym: "epothilone biosynthesis" EXACT [] +synonym: "epothilone formation" EXACT [] +synonym: "epothilone synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0050813 ! epothilone metabolic process + +[Term] +id: GO:0050815 +name: phosphoserine binding +namespace: molecular_function +def: "Interacting selectively with a phosphorylated serine residue within a protein." [GOC:ai] +synonym: "phosphoserine/phosphothreonine binding" BROAD [] +is_a: GO:0045309 ! protein phosphorylated amino acid binding + +[Term] +id: GO:0050816 +name: phosphothreonine binding +namespace: molecular_function +def: "Interacting selectively with a phosphorylated threonine residue within a protein." [GOC:ai] +synonym: "phosphoserine/phosphothreonine binding" BROAD [] +is_a: GO:0045309 ! protein phosphorylated amino acid binding + +[Term] +id: GO:0050817 +name: coagulation +namespace: biological_process +def: "The process by which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_pir +synonym: "clotting" EXACT [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0050818 +name: regulation of coagulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai] +synonym: "regulation of clotting" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0050817 ! coagulation + +[Term] +id: GO:0050819 +name: negative regulation of coagulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of coagulation." [GOC:ai] +synonym: "anticoagulant activity" RELATED [] +synonym: "down regulation of coagulation" EXACT [] +synonym: "down-regulation of coagulation" EXACT [] +synonym: "downregulation of coagulation" EXACT [] +synonym: "inhibition of coagulation" NARROW [] +synonym: "negative regulation of clotting." EXACT [] +is_a: GO:0050818 ! regulation of coagulation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0050817 ! coagulation + +[Term] +id: GO:0050820 +name: positive regulation of coagulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai] +synonym: "activation of coagulation" NARROW [] +synonym: "positive regulation of clotting" EXACT [] +synonym: "stimulation of coagulation" NARROW [] +synonym: "up regulation of coagulation" EXACT [] +synonym: "up-regulation of coagulation" EXACT [] +synonym: "upregulation of coagulation" EXACT [] +is_a: GO:0050818 ! regulation of coagulation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0050817 ! coagulation + +[Term] +id: GO:0050821 +name: protein stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] +subset: gosubset_prok +synonym: "lysosomal protein stabilization" NARROW [] +synonym: "positive regulation of protein stability" EXACT [] +synonym: "protein sequestering" RELATED [] +synonym: "protein stabilization activity" RELATED [] +is_a: GO:0031647 ! regulation of protein stability + +[Term] +id: GO:0050822 +name: peptide stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai] +subset: gosubset_prok +synonym: "peptide stabilization activity" RELATED [] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:0050823 +name: peptide antigen stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai] +subset: gosubset_prok +synonym: "peptide antigen stabilization activity" RELATED [] +is_a: GO:0050822 ! peptide stabilization +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0050824 +name: water binding +namespace: molecular_function +def: "Interacting selectively with water (H2O)." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050825 +name: ice binding +namespace: molecular_function +def: "Interacting selectively with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [http://cancerweb.ncl.ac.uk/] +subset: gosubset_prok +synonym: "antifreeze activity" RELATED [] +synonym: "ice crystal binding" EXACT [] +synonym: "ice nucleation activity" RELATED [] +synonym: "ice nucleation inhibitor activity" RELATED [] +is_a: GO:0050824 ! water binding + +[Term] +id: GO:0050826 +name: response to freezing +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl] +subset: gosubset_prok +synonym: "antifreeze activity" RELATED [] +synonym: "ice nucleation inhibitor activity" RELATED [] +is_a: GO:0009409 ! response to cold + +[Term] +id: GO:0050827 +name: toxin receptor binding +namespace: molecular_function +def: "Interacting selectively with a toxin receptor, a receptor for substances that cause injury to living organisms." [GOC:ai] +synonym: "channel-forming toxin activity" RELATED [] +synonym: "cytotoxin activity" RELATED [] +synonym: "endotoxin activity" RELATED [] +synonym: "enterotoxin activity" RELATED [] +synonym: "exotoxin activity" RELATED [] +synonym: "lipoprotein toxin" RELATED [] +synonym: "neurotoxin activity" RELATED [] +synonym: "pore-forming toxin activity" RELATED [] +synonym: "toxin activity" RELATED [] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0050828 +name: regulation of liquid surface tension +namespace: biological_process +def: "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "regulation of surface tension of a liquid" EXACT [] +synonym: "surfactant activity" RELATED [] +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0050829 +name: defense response to Gram-negative bacterium +namespace: biological_process +def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] +synonym: "defence response to Gram-negative bacteria" EXACT [] +synonym: "defence response to Gram-negative bacterium" EXACT [] +synonym: "defense response to Gram-negative bacteria" EXACT [] +synonym: "Gram-negative antibacterial peptide activity" RELATED [] +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0050830 +name: defense response to Gram-positive bacterium +namespace: biological_process +def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] +subset: gosubset_prok +synonym: "defence response to Gram-positive bacteria" EXACT [] +synonym: "defence response to Gram-positive bacterium" EXACT [] +synonym: "defense response to Gram-positive bacteria" EXACT [] +synonym: "Gram-positive antibacterial peptide activity" RELATED [] +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0050831 +name: male-specific defense response to bacterium +namespace: biological_process +def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai] +synonym: "male-specific antibacterial peptide activity" RELATED [] +synonym: "male-specific defence response to bacteria" EXACT [] +synonym: "male-specific defence response to bacterium" EXACT [] +synonym: "male-specific defense response to bacteria" EXACT [] +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0050832 +name: defense response to fungus +namespace: biological_process +alt_id: GO:0042831 +def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] +synonym: "defence response to fungi" EXACT [] +synonym: "defence response to fungus" EXACT [] +synonym: "defense response to fungi" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0009620 ! response to fungus + +[Term] +id: GO:0050833 +name: pyruvate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0050834 +name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide +namespace: biological_process +def: "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] +subset: gosubset_prok +xref: RESID:AA0355 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0050835 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356] +subset: gosubset_prok +xref: RESID:AA0356 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster +is_a: GO:0050843 ! S-adenosylmethionine catabolic process + +[Term] +id: GO:0050836 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357] +subset: gosubset_prok +xref: RESID:AA0357 +is_a: GO:0018195 ! peptidyl-arginine modification +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0050837 +name: peptide cross-linking via L-cysteinyl-L-selenocysteine +namespace: biological_process +def: "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358] +subset: gosubset_prok +xref: RESID:AA0358 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0050844 ! peptidyl-selenocysteine modification + +[Term] +id: GO:0050838 +name: peptidyl-5-hydroxy-L-lysine trimethylation +namespace: biological_process +def: "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] +subset: gosubset_prok +xref: RESID:AA0359 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0050839 +name: cell adhesion molecule binding +namespace: molecular_function +def: "Interacting selectively with a cell adhesion molecule." [GOC:ai] +synonym: "adhesive extracellular matrix constituent" RELATED [] +synonym: "CAM binding" EXACT [] +synonym: "cell adhesion molecule activity" RELATED [] +synonym: "cell adhesion receptor activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0050840 +name: extracellular matrix binding +namespace: molecular_function +def: "Interacting selectively with a component of the extracellular matrix." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "adhesive extracellular matrix constituent" RELATED [] +synonym: "extracellular matrix constituent binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050841 +name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine +namespace: biological_process +def: "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] +subset: gosubset_prok +synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT [] +synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT [] +xref: RESID:AA0359 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0050842 +name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide +namespace: biological_process +def: "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] +subset: gosubset_prok +xref: RESID:AA0355 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster + +[Term] +id: GO:0050843 +name: S-adenosylmethionine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] +subset: gosubset_prok +synonym: "S-adenosyl methionine catabolic process" EXACT [] +synonym: "S-adenosyl methionine catabolism" EXACT [] +synonym: "S-adenosylmethionine breakdown" EXACT [] +synonym: "S-adenosylmethionine catabolism" EXACT [] +synonym: "S-adenosylmethionine degradation" EXACT [] +synonym: "SAM catabolic process" EXACT [] +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046500 ! S-adenosylmethionine metabolic process + +[Term] +id: GO:0050844 +name: peptidyl-selenocysteine modification +namespace: biological_process +def: "The modification of peptidyl-selenocysteine." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0050845 +name: teichuronic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] +subset: gosubset_prok +synonym: "teichuronic acid anabolism" EXACT [] +synonym: "teichuronic acid biosynthesis" EXACT [] +synonym: "teichuronic acid formation" EXACT [] +synonym: "teichuronic acid synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0050846 ! teichuronic acid metabolic process +relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0050846 +name: teichuronic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] +subset: gosubset_prok +synonym: "teichuronic acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process + +[Term] +id: GO:0050847 +name: progesterone receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870] +synonym: "progesterone receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! steroid hormone receptor signaling pathway + +[Term] +id: GO:0050848 +name: regulation of calcium-mediated signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process by which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] +synonym: "regulation of calcium-mediated signalling" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0050849 +name: negative regulation of calcium-mediated signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592] +synonym: "down regulation of calcium-mediated signaling" EXACT [] +synonym: "down-regulation of calcium-mediated signaling" EXACT [] +synonym: "downregulation of calcium-mediated signaling" EXACT [] +synonym: "inhibition of calcium-mediated signaling" NARROW [] +synonym: "negative regulation of calcium-mediated signalling" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0050848 ! regulation of calcium-mediated signaling +relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0050850 +name: positive regulation of calcium-mediated signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] +synonym: "activation of calcium-mediated signaling" NARROW [] +synonym: "positive regulation of calcium-mediated signalling" EXACT [] +synonym: "stimulation of calcium-mediated signaling" NARROW [] +synonym: "up regulation of calcium-mediated signaling" EXACT [] +synonym: "up-regulation of calcium-mediated signaling" EXACT [] +synonym: "upregulation of calcium-mediated signaling" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0050848 ! regulation of calcium-mediated signaling +relationship: positively_regulates GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0050851 +name: antigen receptor-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add] +synonym: "antigen receptor-mediated signalling pathway" EXACT [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway + +[Term] +id: GO:0050852 +name: T cell receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add] +synonym: "T lymphocyte receptor signaling pathway" EXACT [] +synonym: "T lymphocyte receptor signalling pathway" EXACT [] +synonym: "T-cell receptor signaling pathway" EXACT [] +synonym: "T-cell receptor signalling pathway" EXACT [] +synonym: "T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "TCR signaling pathway" EXACT [] +is_a: GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050853 +name: B cell receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add] +synonym: "B cell receptor signalling pathway" EXACT [] +synonym: "B lymphocyte receptor signaling pathway" EXACT [] +synonym: "B lymphocyte receptor signalling pathway" EXACT [] +synonym: "B-cell receptor signaling pathway" EXACT [] +synonym: "B-cell receptor signalling pathway" EXACT [] +synonym: "B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "B-lymphocyte receptor signalling pathway" EXACT [] +is_a: GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050854 +name: regulation of antigen receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] +synonym: "regulation of antigen receptor mediated signalling pathway" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050855 +name: regulation of B cell receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] +synonym: "regulation of B cell receptor signalling pathway" EXACT [] +synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT [] +synonym: "regulation of B-cell receptor signaling pathway" EXACT [] +synonym: "regulation of B-cell receptor signalling pathway" EXACT [] +synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT [] +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: regulates GO:0050853 ! B cell receptor signaling pathway + +[Term] +id: GO:0050856 +name: regulation of T cell receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] +synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT [] +synonym: "regulation of T-cell receptor signaling pathway" EXACT [] +synonym: "regulation of T-cell receptor signalling pathway" EXACT [] +synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "regulation of TCR signaling pathway" EXACT [] +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: regulates GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0050857 +name: positive regulation of antigen receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] +synonym: "activation of antigen receptor-mediated signaling pathway" NARROW [] +synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT [] +synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW [] +synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050858 +name: negative regulation of antigen receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] +synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW [] +synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050859 +name: negative regulation of B cell receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] +synonym: "down regulation of B cell receptor signaling pathway" EXACT [] +synonym: "down-regulation of B cell receptor signaling pathway" EXACT [] +synonym: "downregulation of B cell receptor signaling pathway" EXACT [] +synonym: "inhibition of B cell receptor signaling pathway" NARROW [] +synonym: "negative regulation of B cell receptor signalling pathway" EXACT [] +synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT [] +synonym: "negative regulation of B-cell receptor signaling pathway" EXACT [] +synonym: "negative regulation of B-cell receptor signalling pathway" EXACT [] +synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT [] +is_a: GO:0050855 ! regulation of B cell receptor signaling pathway +is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway +relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway + +[Term] +id: GO:0050860 +name: negative regulation of T cell receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] +synonym: "down regulation of T cell receptor signaling pathway" EXACT [] +synonym: "down-regulation of T cell receptor signaling pathway" EXACT [] +synonym: "downregulation of T cell receptor signaling pathway" EXACT [] +synonym: "inhibition of T cell receptor signaling pathway" NARROW [] +synonym: "negative regulation of T cell receptor signalling pathway" EXACT [] +synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT [] +synonym: "negative regulation of T-cell receptor signaling pathway" EXACT [] +synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "negative regulation of TCR signaling pathway" EXACT [] +is_a: GO:0050856 ! regulation of T cell receptor signaling pathway +is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway +relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0050861 +name: positive regulation of B cell receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] +synonym: "activation of B cell receptor signaling pathway" NARROW [] +synonym: "positive regulation of B cell receptor signalling pathway" EXACT [] +synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT [] +synonym: "positive regulation of B-cell receptor signaling pathway" EXACT [] +synonym: "positive regulation of B-cell receptor signalling pathway" EXACT [] +synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT [] +synonym: "stimulation of B cell receptor signaling pathway" NARROW [] +synonym: "up regulation of B cell receptor signaling pathway" EXACT [] +synonym: "up-regulation of B cell receptor signaling pathway" EXACT [] +synonym: "upregulation of B cell receptor signaling pathway" EXACT [] +is_a: GO:0050855 ! regulation of B cell receptor signaling pathway +is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway +relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway + +[Term] +id: GO:0050862 +name: positive regulation of T cell receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] +synonym: "activation of T cell receptor signaling pathway" NARROW [] +synonym: "positive regulation of T cell receptor signalling pathway" EXACT [] +synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT [] +synonym: "positive regulation of T-cell receptor signaling pathway" EXACT [] +synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "positive regulation of TCR signaling pathway" EXACT [] +synonym: "stimulation of T cell receptor signaling pathway" NARROW [] +synonym: "up regulation of T cell receptor signaling pathway" EXACT [] +synonym: "up-regulation of T cell receptor signaling pathway" EXACT [] +synonym: "upregulation of T cell receptor signaling pathway" EXACT [] +is_a: GO:0050856 ! regulation of T cell receptor signaling pathway +is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway +relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0050863 +name: regulation of T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai] +synonym: "regulation of T lymphocyte activation" EXACT [] +synonym: "regulation of T-cell activation" EXACT [] +synonym: "regulation of T-lymphocyte activation" EXACT [] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0042110 ! T cell activation + +[Term] +id: GO:0050864 +name: regulation of B cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai] +synonym: "regulation of B lymphocyte activation" EXACT [] +synonym: "regulation of B-cell activation" EXACT [] +synonym: "regulation of B-lymphocyte activation" EXACT [] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0042113 ! B cell activation + +[Term] +id: GO:0050865 +name: regulation of cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0001775 ! cell activation + +[Term] +id: GO:0050866 +name: negative regulation of cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell activation." [GOC:ai] +synonym: "down regulation of cell activation" EXACT [] +synonym: "down-regulation of cell activation" EXACT [] +synonym: "downregulation of cell activation" EXACT [] +synonym: "inhibition of cell activation" NARROW [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0050865 ! regulation of cell activation +relationship: negatively_regulates GO:0001775 ! cell activation + +[Term] +id: GO:0050867 +name: positive regulation of cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] +synonym: "activation of cell activation" NARROW [] +synonym: "stimulation of cell activation" NARROW [] +synonym: "up regulation of cell activation" EXACT [] +synonym: "up-regulation of cell activation" EXACT [] +synonym: "upregulation of cell activation" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0050865 ! regulation of cell activation +relationship: positively_regulates GO:0001775 ! cell activation + +[Term] +id: GO:0050868 +name: negative regulation of T cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation." [GOC:ai] +synonym: "down regulation of T cell activation" EXACT [] +synonym: "down-regulation of T cell activation" EXACT [] +synonym: "downregulation of T cell activation" EXACT [] +synonym: "inhibition of T cell activation" NARROW [] +synonym: "negative regulation of T lymphocyte activation" EXACT [] +synonym: "negative regulation of T-cell activation" EXACT [] +synonym: "negative regulation of T-lymphocyte activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0042110 ! T cell activation + +[Term] +id: GO:0050869 +name: negative regulation of B cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation." [GOC:ai] +synonym: "down regulation of B cell activation" EXACT [] +synonym: "down-regulation of B cell activation" EXACT [] +synonym: "downregulation of B cell activation" EXACT [] +synonym: "inhibition of B cell activation" NARROW [] +synonym: "negative regulation of B lymphocyte activation" EXACT [] +synonym: "negative regulation of B-cell activation" EXACT [] +synonym: "negative regulation of B-lymphocyte activation" EXACT [] +is_a: GO:0050864 ! regulation of B cell activation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0042113 ! B cell activation + +[Term] +id: GO:0050870 +name: positive regulation of T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai] +synonym: "activation of T cell activation" NARROW [] +synonym: "positive regulation of T lymphocyte activation" EXACT [] +synonym: "positive regulation of T-cell activation" EXACT [] +synonym: "positive regulation of T-lymphocyte activation" EXACT [] +synonym: "stimulation of T cell activation" NARROW [] +synonym: "up regulation of T cell activation" EXACT [] +synonym: "up-regulation of T cell activation" EXACT [] +synonym: "upregulation of T cell activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0042110 ! T cell activation + +[Term] +id: GO:0050871 +name: positive regulation of B cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai] +synonym: "activation of B cell activation" NARROW [] +synonym: "positive regulation of B lymphocyte activation" EXACT [] +synonym: "positive regulation of B-cell activation" EXACT [] +synonym: "positive regulation of B-lymphocyte activation" EXACT [] +synonym: "stimulation of B cell activation" NARROW [] +synonym: "up regulation of B cell activation" EXACT [] +synonym: "up-regulation of B cell activation" EXACT [] +synonym: "upregulation of B cell activation" EXACT [] +is_a: GO:0050864 ! regulation of B cell activation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0042113 ! B cell activation + +[Term] +id: GO:0050872 +name: white fat cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945] +synonym: "white adipocyte cell differentiation" EXACT [] +synonym: "white adipocyte differentiation" EXACT [] +is_a: GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0050873 +name: brown fat cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810] +synonym: "brown adipocyte cell differentiation" EXACT [] +synonym: "brown adipocyte differentiation" EXACT [] +is_a: GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0050877 +name: neurological system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio] +subset: goslim_pir +synonym: "neurophysiological process" EXACT [] +synonym: "pan-neural process" RELATED [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0050878 +name: regulation of body fluid levels +namespace: biological_process +def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0050879 +name: multicellular organismal movement +namespace: biological_process +def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0050880 +name: regulation of blood vessel size +namespace: biological_process +def: "Any process that modulates the size of blood vessels." [GOC:ai] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0035150 ! regulation of tube size +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0050881 +name: musculoskeletal movement +namespace: biological_process +def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] +is_a: GO:0050879 ! multicellular organismal movement + +[Term] +id: GO:0050882 +name: voluntary musculoskeletal movement +namespace: biological_process +def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph] +is_a: GO:0050881 ! musculoskeletal movement + +[Term] +id: GO:0050883 +name: musculoskeletal movement, spinal reflex action +namespace: biological_process +def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph] +is_a: GO:0050881 ! musculoskeletal movement +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0050884 +name: neuromuscular process controlling posture +namespace: biological_process +def: "Any process by which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb] +synonym: "regulation of posture" EXACT [] +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0050885 +name: neuromuscular process controlling balance +namespace: biological_process +def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph, http://www.onelook.com/] +synonym: "regulation of balance" RELATED [] +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0050886 +name: endocrine process +namespace: biological_process +def: "Any of the hormonal, neural, and secretory processes that release products into the blood or lymph. These products have specific effects on other organs." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: goslim_pir +synonym: "endocrine physiological process" EXACT [] +synonym: "endocrine physiology" EXACT [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0050887 +name: determination of sensory modality +namespace: biological_process +def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050888 +name: determination of stimulus location +namespace: biological_process +def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050889 +name: determination of stimulus intensity +namespace: biological_process +def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050890 +name: cognition +namespace: biological_process +def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [http://www.onelook.com/, ISBN:0721619908] +is_a: GO:0050877 ! neurological system process + +[Term] +id: GO:0050891 +name: multicellular organismal water homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb] +synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0030104 ! water homeostasis +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0050892 +name: intestinal absorption +namespace: biological_process +def: "Any process by which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph] +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0050893 +name: sensory processing +namespace: biological_process +def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0050877 ! neurological system process +relationship: part_of GO:0007600 ! sensory perception + +[Term] +id: GO:0050894 +name: determination of affect +namespace: biological_process +def: "Any process by which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050896 +name: response to stimulus +namespace: biological_process +alt_id: GO:0051869 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:ai] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "physiological response to stimulus" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0050897 +name: cobalt ion binding +namespace: molecular_function +def: "Interacting selectively with a cobalt (Co) ion." [GOC:ai] +subset: gosubset_prok +synonym: "cobalt binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0050898 +name: nitrile metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "nitrile metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0050899 +name: nitrile catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "nitrile breakdown" EXACT [] +synonym: "nitrile catabolism" EXACT [] +synonym: "nitrile degradation" EXACT [] +is_a: GO:0044270 ! nitrogen compound catabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0050900 +name: leukocyte migration +namespace: biological_process +def: "The movement of leukocytes within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "immune cell migration" EXACT [] +synonym: "immune cell trafficking" EXACT [] +synonym: "leucocyte migration" EXACT [] +synonym: "leucocyte trafficking" EXACT [] +synonym: "leukocyte trafficking" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0050901 +name: leukocyte tethering or rolling +namespace: biological_process +def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +is_a: GO:0007159 ! leukocyte adhesion +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050902 +name: leukocyte adhesive activation +namespace: biological_process +def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "leukocyte adhesive triggering" EXACT [] +is_a: GO:0045321 ! leukocyte activation +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050903 +name: leukocyte activation-dependent arrest +namespace: biological_process +def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +is_a: GO:0007159 ! leukocyte adhesion +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050904 +name: diapedesis +namespace: biological_process +def: "The passage of leukocytes between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:078173514, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic. +is_a: GO:0050900 ! leukocyte migration +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050905 +name: neuromuscular process +namespace: biological_process +def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] +synonym: "neuromotor process" EXACT [] +synonym: "neuromuscular physiological process" EXACT [] +is_a: GO:0050877 ! neurological system process + +[Term] +id: GO:0050906 +name: detection of stimulus involved in sensory perception +namespace: biological_process +def: "The series of events involved in sensory perception in which a sensory stimulus is received by a cell and converted into a molecular signal." [GOC:ai, GOC:dph] +synonym: "sensory detection of stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of stimulus" EXACT [] +synonym: "sensory perception, stimulus detection" EXACT [] +synonym: "sensory transduction" EXACT [] +is_a: GO:0051606 ! detection of stimulus +relationship: part_of GO:0007600 ! sensory perception + +[Term] +id: GO:0050907 +name: detection of chemical stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a sensory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0007606 ! sensory perception of chemical stimulus + +[Term] +id: GO:0050908 +name: detection of light stimulus involved in visual perception +namespace: biological_process +def: "The series of events involved in visual perception in which a sensory light stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of light during visual perception" EXACT [] +synonym: "sensory detection of light stimulus during visual perception" EXACT [] +synonym: "sensory transduction of light during visual perception" EXACT [] +synonym: "sensory transduction of light stimulus during visual perception" EXACT [] +synonym: "visual perception, detection of light stimulus" EXACT [] +synonym: "visual perception, sensory transduction during perception of light" EXACT [] +synonym: "visual perception, sensory transduction of light stimulus" EXACT [] +is_a: GO:0009584 ! detection of visible light +is_a: GO:0050962 ! detection of light stimulus involved in sensory perception +relationship: part_of GO:0007601 ! visual perception + +[Term] +id: GO:0050909 +name: sensory perception of taste +namespace: biological_process +def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells." [GOC:ai, http://www.onelook.com/] +synonym: "gustation" EXACT [] +synonym: "sense of taste" EXACT [] +synonym: "taste" EXACT [] +synonym: "taste perception" EXACT [] +is_a: GO:0007606 ! sensory perception of chemical stimulus + +[Term] +id: GO:0050910 +name: detection of mechanical stimulus involved in sensory perception of sound +namespace: biological_process +alt_id: GO:0009592 +def: "The series of events involved in the perception of sound in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. Sound is picked up in the form of vibrations." [GOC:ai] +synonym: "detection of sound" EXACT [] +synonym: "hearing, sensory transduction of sound" EXACT [] +synonym: "perception of sound, detection of mechanical stimulus" EXACT [] +synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT [] +synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT [] +synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT [] +synonym: "sensory transduction of sound" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0007605 ! sensory perception of sound + +[Term] +id: GO:0050911 +name: detection of chemical stimulus involved in sensory perception of smell +namespace: biological_process +def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of smell, detection of chemical stimulus" EXACT [] +synonym: "perception of smell, sensory detection of chemical stimulus" EXACT [] +synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of smell" EXACT [] +synonym: "sensory detection of scent" EXACT [] +synonym: "sensory detection of smell" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT [] +synonym: "sensory transduction of scent" EXACT [] +synonym: "sensory transduction of smell" EXACT [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0007608 ! sensory perception of smell + +[Term] +id: GO:0050912 +name: detection of chemical stimulus involved in sensory perception of taste +namespace: biological_process +def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of taste, detection of chemical stimulus" EXACT [] +synonym: "perception of taste, sensory detection of chemical stimulus" EXACT [] +synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of taste" EXACT [] +synonym: "sensory detection of taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT [] +synonym: "sensory transduction of taste" EXACT [] +synonym: "taste perception" BROAD [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050913 +name: sensory perception of bitter taste +namespace: biological_process +def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "bitter taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050914 +name: sensory perception of salty taste +namespace: biological_process +def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "salty taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050915 +name: sensory perception of sour taste +namespace: biological_process +def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "sour taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050916 +name: sensory perception of sweet taste +namespace: biological_process +def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "sweet taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050917 +name: sensory perception of umami taste +namespace: biological_process +def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai] +synonym: "umami taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050918 +name: positive chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a higher concentration, in a concentration gradient of a specific chemical." [GOC:ai, GOC:isa_complete] +subset: gosubset_prok +synonym: "chemoattraction" EXACT [] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0050919 +name: negative chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a lower concentration, in a concentration gradient of a specific chemical." [GOC:ai, GOC:isa_complete] +synonym: "chemoaversion" EXACT [] +synonym: "chemorepulsion" EXACT [] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0050920 +name: regulation of chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] +subset: gosubset_prok +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0006935 ! chemotaxis + +[Term] +id: GO:0050921 +name: positive regulation of chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] +subset: gosubset_prok +synonym: "activation of chemotaxis" NARROW [] +synonym: "stimulation of chemotaxis" NARROW [] +synonym: "up regulation of chemotaxis" EXACT [] +synonym: "up-regulation of chemotaxis" EXACT [] +synonym: "upregulation of chemotaxis" EXACT [] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0050920 ! regulation of chemotaxis +relationship: positively_regulates GO:0006935 ! chemotaxis + +[Term] +id: GO:0050922 +name: negative regulation of chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] +synonym: "down regulation of chemotaxis" EXACT [] +synonym: "down-regulation of chemotaxis" EXACT [] +synonym: "downregulation of chemotaxis" EXACT [] +synonym: "inhibition of chemotaxis" NARROW [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0050920 ! regulation of chemotaxis +relationship: negatively_regulates GO:0006935 ! chemotaxis + +[Term] +id: GO:0050923 +name: regulation of negative chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0050919 ! negative chemotaxis + +[Term] +id: GO:0050924 +name: positive regulation of negative chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "activation of negative chemotaxis" NARROW [] +synonym: "stimulation of negative chemotaxis" NARROW [] +synonym: "up regulation of negative chemotaxis" EXACT [] +synonym: "up-regulation of negative chemotaxis" EXACT [] +synonym: "upregulation of negative chemotaxis" EXACT [] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:0050923 ! regulation of negative chemotaxis +relationship: positively_regulates GO:0050919 ! negative chemotaxis + +[Term] +id: GO:0050925 +name: negative regulation of negative chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "down regulation of negative chemotaxis" EXACT [] +synonym: "down-regulation of negative chemotaxis" EXACT [] +synonym: "downregulation of negative chemotaxis" EXACT [] +synonym: "inhibition of negative chemotaxis" NARROW [] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0050923 ! regulation of negative chemotaxis +relationship: negatively_regulates GO:0050919 ! negative chemotaxis + +[Term] +id: GO:0050926 +name: regulation of positive chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +subset: gosubset_prok +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0050918 ! positive chemotaxis + +[Term] +id: GO:0050927 +name: positive regulation of positive chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +subset: gosubset_prok +synonym: "activation of positive chemotaxis" NARROW [] +synonym: "stimulation of positive chemotaxis" NARROW [] +synonym: "up regulation of positive chemotaxis" EXACT [] +synonym: "up-regulation of positive chemotaxis" EXACT [] +synonym: "upregulation of positive chemotaxis" EXACT [] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:0050926 ! regulation of positive chemotaxis +relationship: positively_regulates GO:0050918 ! positive chemotaxis + +[Term] +id: GO:0050928 +name: negative regulation of positive chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "down regulation of positive chemotaxis" EXACT [] +synonym: "down-regulation of positive chemotaxis" EXACT [] +synonym: "downregulation of positive chemotaxis" EXACT [] +synonym: "inhibition of positive chemotaxis" NARROW [] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0050926 ! regulation of positive chemotaxis +relationship: negatively_regulates GO:0050918 ! positive chemotaxis + +[Term] +id: GO:0050929 +name: induction of negative chemotaxis +namespace: biological_process +def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +is_a: GO:0050924 ! positive regulation of negative chemotaxis + +[Term] +id: GO:0050930 +name: induction of positive chemotaxis +namespace: biological_process +def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +subset: gosubset_prok +is_a: GO:0050927 ! positive regulation of positive chemotaxis + +[Term] +id: GO:0050931 +name: pigment cell differentiation +namespace: biological_process +alt_id: GO:0043357 +alt_id: GO:0043358 +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] +comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. +synonym: "chromatophore differentiation" EXACT [] +synonym: "pigment cell differentiation (sensu Nematoda and Protostomia)" EXACT [] +synonym: "pigment cell differentiation (sensu Vertebrata)" EXACT [] +synonym: "pigmented cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +is_a: GO:0048066 ! pigmentation during development + +[Term] +id: GO:0050932 +name: regulation of pigment cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0048070 ! regulation of pigmentation during development +relationship: regulates GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050933 +name: early stripe melanocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836] +synonym: "early stripe melanocyte cell differentiation" EXACT [] +synonym: "early stripe melanophore differentiation" EXACT [] +is_a: GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0050934 +name: late stripe melanocyte differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836] +synonym: "late stripe melanocyte cell differentiation" EXACT [] +synonym: "late stripe melanophore differentiation" EXACT [] +is_a: GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0050935 +name: iridophore differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jic, GOC:mh, PMID:11858836] +synonym: "iridophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050936 +name: xanthophore differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jic, GOC:mh, PMID:11858836] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +synonym: "xanthophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050937 +name: regulation of iridophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0050935 ! iridophore differentiation + +[Term] +id: GO:0050938 +name: regulation of xanthophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0050936 ! xanthophore differentiation + +[Term] +id: GO:0050939 +name: regulation of early stripe melanocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] +synonym: "regulation of early stripe melanophore differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +relationship: regulates GO:0050933 ! early stripe melanocyte differentiation + +[Term] +id: GO:0050940 +name: regulation of late stripe melanocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] +synonym: "regulation of late stripe melanophore differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +relationship: regulates GO:0050934 ! late stripe melanocyte differentiation + +[Term] +id: GO:0050941 +name: negative regulation of pigment cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] +synonym: "down regulation of pigment cell differentiation" EXACT [] +synonym: "down-regulation of pigment cell differentiation" EXACT [] +synonym: "downregulation of pigment cell differentiation" EXACT [] +synonym: "inhibition of pigment cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0048086 ! negative regulation of pigmentation during development +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: negatively_regulates GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050942 +name: positive regulation of pigment cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] +synonym: "activation of pigment cell differentiation" NARROW [] +synonym: "stimulation of pigment cell differentiation" NARROW [] +synonym: "up regulation of pigment cell differentiation" EXACT [] +synonym: "up-regulation of pigment cell differentiation" EXACT [] +synonym: "upregulation of pigment cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0048087 ! positive regulation of pigmentation during development +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: positively_regulates GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050943 +name: negative regulation of iridophore differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai] +synonym: "down regulation of iridophore differentiation" EXACT [] +synonym: "down-regulation of iridophore differentiation" EXACT [] +synonym: "downregulation of iridophore differentiation" EXACT [] +synonym: "inhibition of iridophore differentiation" NARROW [] +is_a: GO:0050937 ! regulation of iridophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0050935 ! iridophore differentiation + +[Term] +id: GO:0050944 +name: negative regulation of xanthophore differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +synonym: "down regulation of xanthophore differentiation" EXACT [] +synonym: "down-regulation of xanthophore differentiation" EXACT [] +synonym: "downregulation of xanthophore differentiation" EXACT [] +synonym: "inhibition of xanthophore differentiation" NARROW [] +is_a: GO:0050938 ! regulation of xanthophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0050936 ! xanthophore differentiation + +[Term] +id: GO:0050945 +name: positive regulation of iridophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai] +synonym: "activation of iridophore differentiation" NARROW [] +synonym: "stimulation of iridophore differentiation" NARROW [] +synonym: "up regulation of iridophore differentiation" EXACT [] +synonym: "up-regulation of iridophore differentiation" EXACT [] +synonym: "upregulation of iridophore differentiation" EXACT [] +is_a: GO:0050937 ! regulation of iridophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0050935 ! iridophore differentiation + +[Term] +id: GO:0050946 +name: positive regulation of xanthophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +synonym: "activation of xanthophore differentiation" NARROW [] +synonym: "stimulation of xanthophore differentiation" NARROW [] +synonym: "up regulation of xanthophore differentiation" EXACT [] +synonym: "up-regulation of xanthophore differentiation" EXACT [] +synonym: "upregulation of xanthophore differentiation" EXACT [] +is_a: GO:0050938 ! regulation of xanthophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0050936 ! xanthophore differentiation + +[Term] +id: GO:0050947 +name: negative regulation of early stripe melanocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] +synonym: "down regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "down-regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "downregulation of early stripe melanocyte differentiation" EXACT [] +synonym: "inhibition of early stripe melanocyte differentiation" NARROW [] +synonym: "negative regulation of early stripe melanophore differentiation" EXACT [] +is_a: GO:0045635 ! negative regulation of melanocyte differentiation +is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation +relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation + +[Term] +id: GO:0050948 +name: positive regulation of early stripe melanocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] +synonym: "activation of early stripe melanocyte differentiation" NARROW [] +synonym: "positive regulation of early stripe melanophore differentiation" EXACT [] +synonym: "stimulation of early stripe melanocyte differentiation" NARROW [] +synonym: "up regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "up-regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "upregulation of early stripe melanocyte differentiation" EXACT [] +is_a: GO:0045636 ! positive regulation of melanocyte differentiation +is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation +relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation + +[Term] +id: GO:0050949 +name: negative regulation of late stripe melanocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] +synonym: "down regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "down-regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "downregulation of late stripe melanocyte differentiation" EXACT [] +synonym: "inhibition of late stripe melanocyte differentiation" NARROW [] +synonym: "negative regulation of late stripe melanophore differentiation" EXACT [] +is_a: GO:0045635 ! negative regulation of melanocyte differentiation +is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation +relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation + +[Term] +id: GO:0050950 +name: positive regulation of late stripe melanocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] +synonym: "activation of late stripe melanocyte differentiation" NARROW [] +synonym: "positive regulation of late stripe melanophore differentiation" EXACT [] +synonym: "stimulation of late stripe melanocyte differentiation" NARROW [] +synonym: "up regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "up-regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "upregulation of late stripe melanocyte differentiation" EXACT [] +is_a: GO:0045636 ! positive regulation of melanocyte differentiation +is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation +relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation + +[Term] +id: GO:0050951 +name: sensory perception of temperature stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "sensory perception of thermal stimulus" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050952 +name: sensory perception of electrical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050953 +name: sensory perception of light stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050954 +name: sensory perception of mechanical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +synonym: "chemi-mechanical coupling" RELATED [] +synonym: "mechanosensory perception" EXACT [] +synonym: "perception of mechanical stimulus" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050955 +name: thermoception +namespace: biological_process +def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, http://www.wikipedia.org/] +synonym: "thermoreception" EXACT [] +is_a: GO:0050951 ! sensory perception of temperature stimulus + +[Term] +id: GO:0050956 +name: electroception +namespace: biological_process +def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, http://www.wikipedia.org/] +synonym: "electroception sense" EXACT [] +synonym: "electroceptive sense" EXACT [] +is_a: GO:0050952 ! sensory perception of electrical stimulus + +[Term] +id: GO:0050957 +name: equilibrioception +namespace: biological_process +def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com, http://www.onelook.com/] +synonym: "sensory perception of orientation with respect to gravity" EXACT [] +is_a: GO:0007600 ! sensory perception +relationship: part_of GO:0050885 ! neuromuscular process controlling balance + +[Term] +id: GO:0050958 +name: magnetoreception +namespace: biological_process +def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, http://www.wikipedia.org/] +synonym: "magnetoception" EXACT [] +synonym: "sensory perception of magnetic field" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050959 +name: echolocation +namespace: biological_process +def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [http://www.onelook.com/, http://www.wikipedia.org/] +synonym: "perception of environment using reflected sound waves" EXACT [] +is_a: GO:0050877 ! neurological system process + +[Term] +id: GO:0050960 +name: detection of temperature stimulus involved in thermoception +namespace: biological_process +def: "The series of events v thermoception in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of heat stimulus during thermoception" NARROW [] +synonym: "sensory detection of temperature stimulus during thermoception" EXACT [] +synonym: "sensory detection of thermal stimulus during thermoception" EXACT [] +synonym: "sensory transduction of heat stimulus during thermoception" NARROW [] +synonym: "sensory transduction of temperature stimulus during thermoception" EXACT [] +synonym: "sensory transduction of thermal stimulus during thermoception" EXACT [] +synonym: "thermoception, sensory detection of heat stimulus" NARROW [] +synonym: "thermoception, sensory detection of temperature stimulus" EXACT [] +synonym: "thermoception, sensory detection of thermal stimulus" EXACT [] +synonym: "thermoception, sensory transduction of heat stimulus" NARROW [] +synonym: "thermoception, sensory transduction of temperature stimulus" EXACT [] +synonym: "thermoception, sensory transduction of thermal stimulus" EXACT [] +is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception +relationship: part_of GO:0050955 ! thermoception + +[Term] +id: GO:0050961 +name: detection of temperature stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of heat stimulus during sensory perception" NARROW [] +synonym: "sensory detection of temperature stimulus" EXACT [] +synonym: "sensory detection of temperature stimulus during sensory perception" EXACT [] +synonym: "sensory detection of thermal stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of heat stimulus" NARROW [] +synonym: "sensory perception, sensory detection of temperature stimulus" EXACT [] +synonym: "sensory perception, sensory detection of thermal stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of heat stimulus" NARROW [] +synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT [] +synonym: "sensory transduction of heat stimulus during sensory perception" NARROW [] +synonym: "sensory transduction of temperature stimulus" EXACT [] +synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT [] +synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT [] +is_a: GO:0016048 ! detection of temperature stimulus +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0050951 ! sensory perception of temperature stimulus + +[Term] +id: GO:0050962 +name: detection of light stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a sensory light stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of light stimulus" EXACT [] +synonym: "sensory detection of light stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of light stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] +synonym: "sensory transduction of light stimulus" EXACT [] +synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] +is_a: GO:0009583 ! detection of light stimulus +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0050953 ! sensory perception of light stimulus + +[Term] +id: GO:0050963 +name: detection of electrical stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of electrical stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT [] +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +is_a: GO:0050981 ! detection of electrical stimulus +relationship: part_of GO:0050952 ! sensory perception of electrical stimulus + +[Term] +id: GO:0050964 +name: detection of electrical stimulus during electroception +namespace: biological_process +def: "The series of events during electroception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "electroception, detection of electrical stimulus" EXACT [] +synonym: "electroception, sensory detection of electrical stimulus" EXACT [] +synonym: "electroception, sensory transduction" EXACT [] +synonym: "electroception, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during electroception" EXACT [] +synonym: "sensory transduction of electrical stimulus during electroception" EXACT [] +is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception +relationship: part_of GO:0050956 ! electroception + +[Term] +id: GO:0050965 +name: detection of temperature stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of pain, detection of temperature stimulus" EXACT [] +synonym: "perception of pain, sensory detection of temperature stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT [] +synonym: "sensory detection of temperature stimulus during perception of pain" EXACT [] +synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT [] +synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT [] +synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT [] +synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT [] +is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception +relationship: part_of GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0050966 +name: detection of mechanical stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of pain, detection of mechanical stimulus" EXACT [] +synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0050967 +name: detection of electrical stimulus during sensory perception of pain +namespace: biological_process +def: "The series of events during the perception of pain in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of pain, detection of electrical stimulus" EXACT [] +synonym: "perception of pain, sensory detection of electrical stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of electrical stimulus during perception of pain" EXACT [] +is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception +relationship: part_of GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0050968 +name: detection of chemical stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a sensory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of pain, detection of chemical stimulus" EXACT [] +synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0050969 +name: detection of chemical stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events involved in magnetoception in which a sensory chemical stimulus is received by a cell and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai] +synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT [] +synonym: "magnetoreception, detection of chemical stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0050977 ! magnetoreception, using chemical stimulus + +[Term] +id: GO:0050970 +name: detection of electrical stimulus during magnetoreception +namespace: biological_process +def: "The series of events during magnetoception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, http://www.wikipedia.org/] +synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT [] +synonym: "magnetoreception, detection of electrical stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of electrical stimulus during magnetoreception" EXACT [] +is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception +relationship: part_of GO:0050978 ! magnetoreception, using electrical stimulus + +[Term] +id: GO:0050971 +name: detection of mechanical stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events involved in magnetoception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai] +synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "magnetoreception, detection of mechanical stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050979 ! magnetoreception, using mechanical stimulus + +[Term] +id: GO:0050972 +name: detection of mechanical stimulus involved in echolocation +namespace: biological_process +def: "The series of events involved in echolocation in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai] +synonym: "echolocation, detection of mechanical stimulus" EXACT [] +synonym: "echolocation, sensory detection of mechanical stimulus" EXACT [] +synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during echolocation" EXACT [] +synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050959 ! echolocation + +[Term] +id: GO:0050973 +name: detection of mechanical stimulus involved in equilibrioception +namespace: biological_process +def: "The series of events involved in equilibrioception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai] +synonym: "equilibrioception, detection of mechanical stimulus" EXACT [] +synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT [] +synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT [] +synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050957 ! equilibrioception + +[Term] +id: GO:0050974 +name: detection of mechanical stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "sensory detection of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT [] +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +is_a: GO:0050982 ! detection of mechanical stimulus +relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0050975 +name: sensory perception of touch +namespace: biological_process +def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] +synonym: "perception of touch" EXACT [] +synonym: "tactile sense" EXACT [] +synonym: "taction" EXACT [] +synonym: "tactition" EXACT [] +is_a: GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0050976 +name: detection of mechanical stimulus involved in sensory perception of touch +namespace: biological_process +def: "The series of events involved in the perception of touch in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "perception of touch, detection of mechanical stimulus" EXACT [] +synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT [] +synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT [] +synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT [] +synonym: "tactition, sensory detection of mechanical stimulus" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050975 ! sensory perception of touch + +[Term] +id: GO:0050977 +name: magnetoreception, using chemical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, http://www.wikipedia.org/] +synonym: "magnetoreception by chemical stimulus" EXACT [] +synonym: "magnetoreception through chemical stimulus" EXACT [] +synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT [] +is_a: GO:0007606 ! sensory perception of chemical stimulus +is_a: GO:0050958 ! magnetoreception + +[Term] +id: GO:0050978 +name: magnetoreception, using electrical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, http://www.wikipedia.org/] +synonym: "magnetoreception by electrical stimulus" EXACT [] +synonym: "magnetoreception through electrical stimulus" EXACT [] +synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT [] +is_a: GO:0050952 ! sensory perception of electrical stimulus +is_a: GO:0050958 ! magnetoreception + +[Term] +id: GO:0050979 +name: magnetoreception, using mechanical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, http://www.wikipedia.org/] +synonym: "magnetoreception by sensory perception of mechanical stimulus" EXACT [] +synonym: "magnetoreception through mechanical stimulus" EXACT [] +synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT [] +is_a: GO:0050954 ! sensory perception of mechanical stimulus +is_a: GO:0050958 ! magnetoreception + +[Term] +id: GO:0050980 +name: detection of light stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events involved in magnetoception in which a light stimulus is received by a cell and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, http://www.wikipedia.org/] +synonym: "magnetoreception, detection of light stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of light stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of light stimulus" EXACT [] +synonym: "sensory detection of light stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of light stimulus during magnetoreception" EXACT [] +is_a: GO:0050962 ! detection of light stimulus involved in sensory perception +relationship: part_of GO:0050958 ! magnetoreception + +[Term] +id: GO:0050981 +name: detection of electrical stimulus +namespace: biological_process +def: "The series of events by which an electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +is_a: GO:0009582 ! detection of abiotic stimulus +is_a: GO:0051602 ! response to electrical stimulus + +[Term] +id: GO:0050982 +name: detection of mechanical stimulus +namespace: biological_process +def: "The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0050983 +name: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase +namespace: biological_process +def: "The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN] +comment: Note that this reaction is catalyzed by a single enzyme but since it has multiple steps, it appears in the process ontology. +subset: gosubset_prok +synonym: "(4-aminobutyl)lysine synthase activity" RELATED [EC:2.5.1.46] +synonym: "[eIF-5A]-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46] +synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT [] +synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT [] +xref: EC:2.5.1.46 +xref: MetaCyc:2.5.1.46-RXN +is_a: GO:0046203 ! spermidine catabolic process + +[Term] +id: GO:0050984 +name: peptidyl-serine sulfation +namespace: biological_process +def: "The posttranslational sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361] +subset: gosubset_prok +xref: RESID:AA0361 +is_a: GO:0006477 ! protein amino acid sulfation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0050985 +name: peptidyl-threonine sulfation +namespace: biological_process +def: "The posttranslational sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362] +subset: gosubset_prok +xref: RESID:AA0362 +is_a: GO:0006477 ! protein amino acid sulfation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0050986 +name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360] +subset: gosubset_prok +xref: RESID:AA0360 +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0050987 +name: enzyme active site formation via O-sulfo-L-serine +namespace: biological_process +def: "The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361] +subset: gosubset_prok +xref: RESID:AA0361 +is_a: GO:0018307 ! enzyme active site formation +is_a: GO:0050984 ! peptidyl-serine sulfation + +[Term] +id: GO:0050988 +name: N-terminal peptidyl-methionine carboxylation +namespace: biological_process +def: "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363] +subset: gosubset_prok +xref: RESID:AA0363 +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0050989 ! N-terminal protein amino acid carboxylation + +[Term] +id: GO:0050989 +name: N-terminal protein amino acid carboxylation +namespace: biological_process +def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai] +subset: gosubset_prok +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0050990 +name: N-terminal protein amino acid carbamoylation +namespace: biological_process +def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai] +subset: gosubset_prok +synonym: "N-terminal protein amino acid carbamylation" EXACT [] +is_a: GO:0018409 ! peptide or protein amino-terminal blocking + +[Term] +id: GO:0050991 +name: enzyme active site formation via O-sulfo-L-threonine +namespace: biological_process +def: "The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362] +subset: gosubset_prok +xref: RESID:AA0362 +is_a: GO:0018307 ! enzyme active site formation +is_a: GO:0050985 ! peptidyl-threonine sulfation + +[Term] +id: GO:0050992 +name: dimethylallyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "dimethylallyl diphosphate anabolism" EXACT [] +synonym: "dimethylallyl diphosphate biosynthesis" EXACT [] +synonym: "dimethylallyl diphosphate formation" EXACT [] +synonym: "dimethylallyl diphosphate synthesis" EXACT [] +synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT [] +synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT [] +synonym: "DPP biosynthesis" EXACT [] +synonym: "DPP biosynthetic process" EXACT [] +is_a: GO:0016091 ! prenol biosynthetic process +is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process + +[Term] +id: GO:0050993 +name: dimethylallyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "dimethylallyl diphosphate metabolism" EXACT [] +synonym: "dimethylallyl pyrophosphate metabolic process" EXACT [] +synonym: "dimethylallyl pyrophosphate metabolism" EXACT [] +synonym: "DPP metabolic process" EXACT [] +synonym: "DPP metabolism" EXACT [] +is_a: GO:0016090 ! prenol metabolic process + +[Term] +id: GO:0050994 +name: regulation of lipid catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] +synonym: "regulation of lipid breakdown" EXACT [] +synonym: "regulation of lipid catabolism" EXACT [] +synonym: "regulation of lipid degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: regulates GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0050995 +name: negative regulation of lipid catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] +synonym: "down regulation of lipid catabolic process" EXACT [] +synonym: "down-regulation of lipid catabolic process" EXACT [] +synonym: "downregulation of lipid catabolic process" EXACT [] +synonym: "inhibition of lipid catabolic process" NARROW [] +synonym: "negative regulation of lipid breakdown" EXACT [] +synonym: "negative regulation of lipid catabolism" EXACT [] +synonym: "negative regulation of lipid degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: negatively_regulates GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0050996 +name: positive regulation of lipid catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] +synonym: "activation of lipid catabolic process" NARROW [] +synonym: "positive regulation of lipid breakdown" EXACT [] +synonym: "positive regulation of lipid catabolism" EXACT [] +synonym: "positive regulation of lipid degradation" EXACT [] +synonym: "stimulation of lipid catabolic process" NARROW [] +synonym: "up regulation of lipid catabolic process" EXACT [] +synonym: "up-regulation of lipid catabolic process" EXACT [] +synonym: "upregulation of lipid catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: positively_regulates GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0050997 +name: quaternary ammonium group binding +namespace: molecular_function +def: "Interacting selectively with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai] +subset: gosubset_prok +synonym: "quaternary amine binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050998 +name: nitric-oxide synthase binding +namespace: molecular_function +def: "Interacting selectively with the enzyme nitric-oxide synthase." [GOC:ai] +synonym: "NOS binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0050999 +name: regulation of nitric-oxide synthase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai] +subset: gosubset_prok +synonym: "nitric-oxide synthase regulator" EXACT [] +synonym: "NOS regulator" EXACT [] +synonym: "regulation of NOS activity" EXACT [] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0051000 +name: positive regulation of nitric-oxide synthase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai] +subset: gosubset_prok +synonym: "activation of nitric-oxide synthase activity" NARROW [] +synonym: "nitric-oxide synthase activator" EXACT [] +synonym: "NOS activator" EXACT [] +synonym: "positive regulation of NOS activity" EXACT [] +synonym: "stimulation of nitric-oxide synthase activity" NARROW [] +synonym: "up regulation of nitric-oxide synthase activity" EXACT [] +synonym: "up-regulation of nitric-oxide synthase activity" EXACT [] +synonym: "upregulation of nitric-oxide synthase activity" EXACT [] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:0050999 ! regulation of nitric-oxide synthase activity + +[Term] +id: GO:0051001 +name: negative regulation of nitric-oxide synthase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of nitric-oxide synthase activity" EXACT [] +synonym: "down-regulation of nitric-oxide synthase activity" EXACT [] +synonym: "downregulation of nitric-oxide synthase activity" EXACT [] +synonym: "inhibition of nitric-oxide synthase activity" NARROW [] +synonym: "negative regulation of NOS activity" EXACT [] +synonym: "nitric-oxide synthase inhibitor" NARROW [] +synonym: "NOS inhibitor" NARROW [] +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:0050999 ! regulation of nitric-oxide synthase activity + +[Term] +id: GO:0051002 +name: ligase activity, forming nitrogen-metal bonds +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a nitrogen-metal bond." [EC:6.6.-.-] +subset: gosubset_prok +xref: EC:6.6 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0051003 +name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-] +subset: gosubset_prok +xref: EC:6.6.1 +is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds + +[Term] +id: GO:0051004 +name: regulation of lipoprotein lipase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai] +subset: gosubset_prok +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0051005 +name: negative regulation of lipoprotein lipase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of lipoprotein lipase activity" EXACT [] +synonym: "down-regulation of lipoprotein lipase activity" EXACT [] +synonym: "downregulation of lipoprotein lipase activity" EXACT [] +synonym: "inhibition of lipoprotein lipase activity" NARROW [] +is_a: GO:0051004 ! regulation of lipoprotein lipase activity +is_a: GO:0060192 ! negative regulation of lipase activity + +[Term] +id: GO:0051006 +name: positive regulation of lipoprotein lipase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai] +subset: gosubset_prok +synonym: "activation of lipoprotein lipase activity" NARROW [] +synonym: "stimulation of lipoprotein lipase activity" NARROW [] +synonym: "up regulation of lipoprotein lipase activity" EXACT [] +synonym: "up-regulation of lipoprotein lipase activity" EXACT [] +synonym: "upregulation of lipoprotein lipase activity" EXACT [] +is_a: GO:0051004 ! regulation of lipoprotein lipase activity +is_a: GO:0060193 ! positive regulation of lipase activity + +[Term] +id: GO:0051007 +name: squalene-hopene cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17] +subset: gosubset_prok +synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17] +synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581] +xref: EC:5.4.99.17 +is_a: GO:0016866 ! intramolecular transferase activity +is_a: GO:0034072 ! squalene cyclase activity + +[Term] +id: GO:0051008 +name: Hsp27 protein binding +namespace: molecular_function +def: "Interacting selectively with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai] +is_a: GO:0031072 ! heat shock protein binding + +[Term] +id: GO:0051009 +name: O-acetylhomoserine sulfhydrylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acetyl-L-homoserine + H2S = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN] +xref: MetaCyc:ACETYLHOMOSER-CYS-RXN +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0051010 +name: microtubule plus-end binding +namespace: molecular_function +def: "Interacting selectively with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] +is_a: GO:0008017 ! microtubule binding + +[Term] +id: GO:0051011 +name: microtubule minus-end binding +namespace: molecular_function +def: "Interacting selectively with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] +is_a: GO:0008017 ! microtubule binding + +[Term] +id: GO:0051012 +name: microtubule sliding +namespace: biological_process +def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826] +synonym: "microtubule translocation" EXACT [] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0051013 +name: microtubule severing +namespace: biological_process +def: "The process by which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234] +synonym: "microtubule severing activity" RELATED [] +is_a: GO:0007017 ! microtubule-based process + +[Term] +id: GO:0051014 +name: actin filament severing +namespace: biological_process +def: "The process by which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] +synonym: "actin filament severing activity" RELATED [] +synonym: "barbed-end actin capping/severing activity" RELATED [] +synonym: "F-actin severing" EXACT [] +is_a: GO:0030029 ! actin filament-based process + +[Term] +id: GO:0051015 +name: actin filament binding +namespace: molecular_function +def: "Interacting selectively with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +synonym: "actin cross-linking activity" RELATED [] +synonym: "F-actin binding" EXACT [] +is_a: GO:0003779 ! actin binding + +[Term] +id: GO:0051016 +name: barbed-end actin filament capping +namespace: biological_process +def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] +synonym: "barbed-end actin capping activity" EXACT [] +synonym: "barbed-end F-actin capping activity" EXACT [] +synonym: "plus-end actin filament capping activity" EXACT [] +synonym: "plus-end F-actin capping activity" EXACT [] +is_a: GO:0051693 ! actin filament capping + +[Term] +id: GO:0051017 +name: actin filament bundle formation +namespace: biological_process +def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] +synonym: "actin bundling activity" RELATED [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0051018 +name: protein kinase A binding +namespace: molecular_function +def: "Interacting selectively with any subunit of protein kinase A." [GOC:ai] +comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity. +synonym: "PKA binding" EXACT [] +synonym: "protein kinase A anchoring activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051019 +name: mitogen-activated protein kinase binding +namespace: molecular_function +def: "Interacting selectively with a mitogen-activated protein kinase." [GOC:ai] +synonym: "MAP kinase binding" EXACT [] +synonym: "MAP-kinase anchoring activity" RELATED [] +synonym: "MAPK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0051020 +name: GTPase binding +namespace: molecular_function +def: "Interacting selectively with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0051021 +name: GDP-dissociation inhibitor binding +namespace: molecular_function +def: "Interacting selectively with a GDP-dissociation inhibitor protein." [GOC:ai] +synonym: "GDI binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051022 +name: Rho GDP-dissociation inhibitor binding +namespace: molecular_function +def: "Interacting selectively with a Rho GDP-dissociation inhibitor protein." [GOC:ai] +synonym: "Rho GDI binding" EXACT [] +is_a: GO:0051021 ! GDP-dissociation inhibitor binding + +[Term] +id: GO:0051023 +name: regulation of immunoglobulin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai] +synonym: "regulation of antibody secretion" EXACT [] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0048305 ! immunoglobulin secretion + +[Term] +id: GO:0051024 +name: positive regulation of immunoglobulin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai] +synonym: "activation of immunoglobulin secretion" NARROW [] +synonym: "positive regulation of antibody secretion" EXACT [] +synonym: "stimulation of immunoglobulin secretion" NARROW [] +synonym: "up regulation of immunoglobulin secretion" EXACT [] +synonym: "up-regulation of immunoglobulin secretion" EXACT [] +synonym: "upregulation of immunoglobulin secretion" EXACT [] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:0051023 ! regulation of immunoglobulin secretion +relationship: positively_regulates GO:0048305 ! immunoglobulin secretion + +[Term] +id: GO:0051025 +name: negative regulation of immunoglobulin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai] +synonym: "down regulation of immunoglobulin secretion" EXACT [] +synonym: "down-regulation of immunoglobulin secretion" EXACT [] +synonym: "downregulation of immunoglobulin secretion" EXACT [] +synonym: "inhibition of immunoglobulin secretion" NARROW [] +synonym: "negative regulation of antibody secretion" EXACT [] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:0051023 ! regulation of immunoglobulin secretion +relationship: negatively_regulates GO:0048305 ! immunoglobulin secretion + +[Term] +id: GO:0051026 +name: chiasma formation +namespace: biological_process +def: "The cell cycle process whereby a connection between chromatids forms, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007129 ! synapsis + +[Term] +id: GO:0051027 +name: DNA transport +namespace: biological_process +def: "The directed movement of RNA, deoxyribonucleic acid, into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0050657 ! nucleic acid transport + +[Term] +id: GO:0051028 +name: mRNA transport +namespace: biological_process +def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of, within or between cells." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051029 +name: rRNA transport +namespace: biological_process +def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of, within or between cells." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051030 +name: snRNA transport +namespace: biological_process +def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of, within or between cells." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051031 +name: tRNA transport +namespace: biological_process +def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of, within or between cells." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051032 +name: nucleic acid transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] +is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity + +[Term] +id: GO:0051033 +name: RNA transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0051032 ! nucleic acid transmembrane transporter activity + +[Term] +id: GO:0051034 +name: tRNA transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0051033 ! RNA transmembrane transporter activity + +[Term] +id: GO:0051035 +name: DNA transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0051032 ! nucleic acid transmembrane transporter activity + +[Term] +id: GO:0051036 +name: regulation of endosome size +namespace: biological_process +def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai] +synonym: "endosome enlargement" RELATED [] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0051037 +name: regulation of transcription, meiotic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription during meiosis." [GOC:go_curators] +synonym: "meiotic regulation of transcription" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent + +[Term] +id: GO:0051038 +name: negative regulation of transcription, meiotic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai] +synonym: "down regulation of transcription, meiotic" EXACT [] +synonym: "down-regulation of transcription, meiotic" EXACT [] +synonym: "downregulation of transcription, meiotic" EXACT [] +synonym: "inhibition of transcription, meiotic" NARROW [] +synonym: "meiotic repression of transcription" EXACT [] +synonym: "negative regulation of meiotic transcription" EXACT [] +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +is_a: GO:0051037 ! regulation of transcription, meiotic + +[Term] +id: GO:0051039 +name: positive regulation of transcription, meiotic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription during meiosis." [GOC:ai] +synonym: "activation of transcription, meiotic" NARROW [] +synonym: "positive regulation of meiotic transcription" EXACT [] +synonym: "stimulation of transcription, meiotic" NARROW [] +synonym: "up regulation of transcription, meiotic" EXACT [] +synonym: "up-regulation of transcription, meiotic" EXACT [] +synonym: "upregulation of transcription, meiotic" EXACT [] +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +is_a: GO:0051037 ! regulation of transcription, meiotic + +[Term] +id: GO:0051040 +name: regulation of calcium-independent cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion + +[Term] +id: GO:0051041 +name: positive regulation of calcium-independent cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] +synonym: "activation of calcium-independent cell-cell adhesion" NARROW [] +synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW [] +synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion +relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion + +[Term] +id: GO:0051042 +name: negative regulation of calcium-independent cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] +synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion +relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion + +[Term] +id: GO:0051043 +name: regulation of membrane protein ectodomain proteolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai] +subset: gosubset_prok +is_a: GO:0030162 ! regulation of proteolysis +relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051044 +name: positive regulation of membrane protein ectodomain proteolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai] +subset: gosubset_prok +synonym: "activation of membrane protein ectodomain proteolysis" NARROW [] +synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW [] +synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT [] +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis +relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051045 +name: negative regulation of membrane protein ectodomain proteolysis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW [] +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis +relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051046 +name: regulation of secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a substance from a cell or group of cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0046903 ! secretion + +[Term] +id: GO:0051047 +name: positive regulation of secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a substance from a cell or group of cells." [GOC:ai] +synonym: "activation of secretion" NARROW [] +synonym: "stimulation of secretion" NARROW [] +synonym: "up regulation of secretion" EXACT [] +synonym: "up-regulation of secretion" EXACT [] +synonym: "upregulation of secretion" EXACT [] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0046903 ! secretion + +[Term] +id: GO:0051048 +name: negative regulation of secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a substance from a cell or group of cells." [GOC:ai] +synonym: "down regulation of secretion" EXACT [] +synonym: "down-regulation of secretion" EXACT [] +synonym: "downregulation of secretion" EXACT [] +synonym: "inhibition of secretion" NARROW [] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0046903 ! secretion + +[Term] +id: GO:0051049 +name: regulation of transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0006810 ! transport + +[Term] +id: GO:0051050 +name: positive regulation of transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "activation of transport" NARROW [] +synonym: "stimulation of transport" NARROW [] +synonym: "up regulation of transport" EXACT [] +synonym: "up-regulation of transport" EXACT [] +synonym: "upregulation of transport" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051049 ! regulation of transport +relationship: positively_regulates GO:0006810 ! transport + +[Term] +id: GO:0051051 +name: negative regulation of transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of transport" EXACT [] +synonym: "down-regulation of transport" EXACT [] +synonym: "downregulation of transport" EXACT [] +synonym: "inhibition of transport" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051049 ! regulation of transport +relationship: negatively_regulates GO:0006810 ! transport + +[Term] +id: GO:0051052 +name: regulation of DNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of DNA metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0051053 +name: negative regulation of DNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of DNA metabolic process" EXACT [] +synonym: "down-regulation of DNA metabolic process" EXACT [] +synonym: "downregulation of DNA metabolic process" EXACT [] +synonym: "inhibition of DNA metabolic process" NARROW [] +synonym: "negative regulation of DNA metabolism" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: negatively_regulates GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0051054 +name: positive regulation of DNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] +subset: gosubset_prok +synonym: "activation of DNA metabolic process" NARROW [] +synonym: "positive regulation of DNA metabolism" EXACT [] +synonym: "stimulation of DNA metabolic process" NARROW [] +synonym: "up regulation of DNA metabolic process" EXACT [] +synonym: "up-regulation of DNA metabolic process" EXACT [] +synonym: "upregulation of DNA metabolic process" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: positively_regulates GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0051055 +name: negative regulation of lipid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of lipid biosynthetic process" EXACT [] +synonym: "down-regulation of lipid biosynthetic process" EXACT [] +synonym: "downregulation of lipid biosynthetic process" EXACT [] +synonym: "inhibition of lipid biosynthetic process" NARROW [] +synonym: "negative regulation of lipid anabolism" EXACT [] +synonym: "negative regulation of lipid biosynthesis" EXACT [] +synonym: "negative regulation of lipid formation" EXACT [] +synonym: "negative regulation of lipid synthesis" EXACT [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0051056 +name: regulation of small GTPase mediated signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0051057 +name: positive regulation of small GTPase mediated signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] +synonym: "activation of small GTPase mediated signal transduction" NARROW [] +synonym: "stimulation of small GTPase mediated signal transduction" NARROW [] +synonym: "up regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "up-regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "upregulation of small GTPase mediated signal transduction" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +relationship: positively_regulates GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0051058 +name: negative regulation of small GTPase mediated signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] +synonym: "down regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "down-regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "downregulation of small GTPase mediated signal transduction" EXACT [] +synonym: "inhibition of small GTPase mediated signal transduction" NARROW [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +relationship: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0051059 +name: NF-kappaB binding +namespace: molecular_function +def: "Interacting selectively with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0051060 +name: pullulanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41] +subset: gosubset_prok +synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT [] +synonym: "amylopectin 6-glucanohydrolase activity" EXACT [] +synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41] +synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41] +synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.41] +synonym: "pullulan 6-glucanohydrolase activity" EXACT [] +synonym: "pullulan alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.41] +synonym: "R-enzyme" RELATED [EC:3.2.1.41] +xref: EC:3.2.1.41 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051061 +name: ADP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN] +synonym: "ADP reduction" RELATED [] +xref: MetaCyc:ADPREDUCT-RXN +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0051062 +name: UDP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN] +synonym: "UDP reduction" RELATED [] +xref: MetaCyc:UDPREDUCT-RXN +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0051063 +name: CDP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN] +synonym: "CDP reduction" RELATED [] +xref: MetaCyc:CDPREDUCT-RXN +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0051064 +name: TTP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] +synonym: "TTP reduction" RELATED [] +xref: EC:1.17.4.- +is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity + +[Term] +id: GO:0051065 +name: CTP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] +synonym: "CTP reduction" RELATED [] +xref: EC:1.17.4.- +is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity + +[Term] +id: GO:0051066 +name: dihydrobiopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [http://www.onelook.com] +subset: gosubset_prok +synonym: "dihydrobiopterin metabolism" EXACT [] +synonym: "dihydrobiopterin reduction" NARROW [] +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0051067 +name: dihydropteridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dihydropteridine, a bicyclic compound with the formula C6H6N4." [GOC:ai] +subset: gosubset_prok +synonym: "dihydropteridine metabolism" EXACT [] +synonym: "dihydropteridine reduction" NARROW [] +is_a: GO:0042558 ! pteridine and derivative metabolic process + +[Term] +id: GO:0051068 +name: dihydrolipoamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464] +subset: gosubset_prok +synonym: "dihydrolipoamide metabolism" EXACT [] +synonym: "dihydrolipoamide reduction" NARROW [] +synonym: "dihydrothioctamide metabolic process" EXACT [] +synonym: "dihydrothioctamide metabolism" EXACT [] +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051069 +name: galactomannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/] +subset: gosubset_prok +synonym: "galactomannan metabolism" EXACT [] +is_a: GO:0006080 ! substituted mannan metabolic process + +[Term] +id: GO:0051070 +name: galactomannan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] +subset: gosubset_prok +synonym: "galactomannan anabolism" EXACT [] +synonym: "galactomannan biosynthesis" EXACT [] +synonym: "galactomannan formation" EXACT [] +synonym: "galactomannan synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0051069 ! galactomannan metabolic process + +[Term] +id: GO:0051071 +name: 4,6-pyruvylated galactose residue metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] +subset: gosubset_prok +synonym: "4,6-pyruvylated galactose residue metabolism" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT [] +synonym: "PvGal metabolic process" EXACT [] +synonym: "PvGal metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0051072 +name: 4,6-pyruvylated galactose residue biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] +subset: gosubset_prok +synonym: "4,6-pyruvylated galactose residue anabolism" EXACT [] +synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT [] +synonym: "4,6-pyruvylated galactose residue formation" EXACT [] +synonym: "4,6-pyruvylated galactose residue synthesis" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT [] +synonym: "PvGal biosynthesis" EXACT [] +synonym: "PvGal biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0051071 ! 4,6-pyruvylated galactose residue metabolic process + +[Term] +id: GO:0051073 +name: adenosylcobinamide-GDP ribazoletransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN] +synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" EXACT [EC:2.7.8.26] +synonym: "cobalamin (5'-phosphate) synthase activity" EXACT [EC:2.7.8.26] +synonym: "cobalamin synthase activity" EXACT [] +synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26] +synonym: "CobS" RELATED [EC:2.7.8.26] +xref: EC:2.7.8.26 +xref: MetaCyc:COBALAMINSYN-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0051074 +name: protein tetramerization activity +namespace: molecular_function +def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] +comment: This term was made obsolete because it represents a process. +is_obsolete: true +replaced_by: GO:0051262 + +[Term] +id: GO:0051075 +name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA [preQ1-tRNA] = adenine + methionine + epoxyqueuosine-tRNA [oQ-tRNA]." [PMID:12731872] +subset: gosubset_prok +synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT [] +is_a: GO:0016740 ! transferase activity +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0051076 +name: Gram-positive bacterial binding +namespace: molecular_function +def: "Interacting selectively with any part of a Gram-positive bacterial cell." [GOC:ai] +subset: gosubset_prok +synonym: "binding to Gram-positive bacterium" EXACT [] +synonym: "Gram-positive bacterium binding" EXACT [] +is_a: GO:0008367 ! bacterial binding + +[Term] +id: GO:0051077 +name: secondary cell septum +namespace: cellular_component +def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814] +synonym: "secondary cell septum (sensu Fungi)" EXACT [] +synonym: "secondary septum (sensu Fungi)" EXACT [] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0051078 +name: meiotic nuclear envelope disassembly +namespace: biological_process +def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf] +synonym: "meiotic nuclear envelope breakdown" EXACT [] +synonym: "meiotic nuclear envelope catabolism" EXACT [] +synonym: "meiotic nuclear envelope degradation" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051081 ! nuclear envelope disassembly +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051079 +name: meiosis I nuclear envelope disassembly +namespace: biological_process +def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf] +synonym: "meiosis I nuclear envelope breakdown" EXACT [] +synonym: "meiosis I nuclear envelope catabolism" EXACT [] +synonym: "meiosis I nuclear envelope degradation" EXACT [] +is_a: GO:0051078 ! meiotic nuclear envelope disassembly +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0051080 +name: meiosis II nuclear envelope disassembly +namespace: biological_process +def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf] +synonym: "meiosis II nuclear envelope breakdown" EXACT [] +synonym: "meiosis II nuclear envelope catabolism" EXACT [] +synonym: "meiosis II nuclear envelope degradation" EXACT [] +is_a: GO:0051078 ! meiotic nuclear envelope disassembly +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0051081 +name: nuclear envelope disassembly +namespace: biological_process +def: "The controlled breakdown of the nuclear envelope in the context of a normal process." [GOC:ai] +synonym: "nuclear envelope breakdown" EXACT [] +synonym: "nuclear envelope catabolism" EXACT [] +synonym: "nuclear envelope degradation" EXACT [] +is_a: GO:0006998 ! nuclear envelope organization +is_a: GO:0030397 ! membrane disassembly + +[Term] +id: GO:0051082 +name: unfolded protein binding +namespace: molecular_function +def: "Interacting selectively with an unfolded protein." [GOC:ai] +subset: gosubset_prok +synonym: "binding unfolded ER proteins" NARROW [] +synonym: "chaperone activity" RELATED [] +synonym: "fimbrium-specific chaperone activity" RELATED [] +synonym: "glycoprotein-specific chaperone activity" RELATED [] +synonym: "histone-specific chaperone activity" RELATED [] +synonym: "ribosomal chaperone activity" RELATED [] +synonym: "tubulin-specific chaperone activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051083 +name: 'de novo' cotranslational protein folding +namespace: biological_process +alt_id: GO:0006444 +def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb] +subset: gosubset_prok +synonym: "'de novo' co-translational protein folding" EXACT [] +synonym: "multidomain protein assembly" EXACT [] +synonym: "nascent polypeptide association" EXACT [] +is_a: GO:0006458 ! 'de novo' protein folding + +[Term] +id: GO:0051084 +name: 'de novo' posttranslational protein folding +namespace: biological_process +def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] +subset: gosubset_prok +synonym: "'de novo' post-translational protein folding" EXACT [] +is_a: GO:0006458 ! 'de novo' protein folding + +[Term] +id: GO:0051085 +name: chaperone cofactor-dependent protein folding +namespace: biological_process +def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] +subset: gosubset_prok +synonym: "chaperone co-factor-dependent protein folding" EXACT [] +is_a: GO:0051084 ! 'de novo' posttranslational protein folding + +[Term] +id: GO:0051086 +name: chaperone cofactor-independent protein folding +namespace: biological_process +def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] +subset: gosubset_prok +is_a: GO:0051084 ! 'de novo' posttranslational protein folding + +[Term] +id: GO:0051087 +name: chaperone binding +namespace: molecular_function +def: "Interacting selectively with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com] +subset: gosubset_prok +synonym: "chaperone protein binding" EXACT [] +synonym: "co-chaperone activity" RELATED [] +synonym: "co-chaperonin activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051088 +name: PMA-inducible membrane protein ectodomain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508] +is_a: GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051089 +name: constitutive protein ectodomain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508] +subset: gosubset_prok +is_a: GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051090 +name: regulation of transcription factor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] +subset: gosubset_prok +is_a: GO:0045449 ! regulation of transcription +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:0051091 +name: positive regulation of transcription factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] +subset: gosubset_prok +synonym: "activation of transcription factor activity" NARROW [] +synonym: "stimulation of transcription factor activity" NARROW [] +synonym: "up regulation of transcription factor activity" EXACT [] +synonym: "up-regulation of transcription factor activity" EXACT [] +synonym: "upregulation of transcription factor activity" EXACT [] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:0051090 ! regulation of transcription factor activity + +[Term] +id: GO:0051092 +name: positive regulation of NF-kappaB transcription factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030] +synonym: "activation of NF-kappaB" EXACT [] +synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "NF-kappaB activation" EXACT [] +is_a: GO:0051091 ! positive regulation of transcription factor activity + +[Term] +id: GO:0051093 +name: negative regulation of developmental process +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of developmental process" EXACT [] +synonym: "down-regulation of developmental process" EXACT [] +synonym: "downregulation of developmental process" EXACT [] +synonym: "inhibition of developmental process" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050793 ! regulation of developmental process +relationship: negatively_regulates GO:0032502 ! developmental process + +[Term] +id: GO:0051094 +name: positive regulation of developmental process +namespace: biological_process +def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] +subset: gosubset_prok +synonym: "activation of developmental process" NARROW [] +synonym: "stimulation of developmental process" NARROW [] +synonym: "up regulation of developmental process" EXACT [] +synonym: "up-regulation of developmental process" EXACT [] +synonym: "upregulation of developmental process" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0050793 ! regulation of developmental process +relationship: positively_regulates GO:0032502 ! developmental process + +[Term] +id: GO:0051095 +name: regulation of helicase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai] +subset: gosubset_prok +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051096 +name: positive regulation of helicase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a helicase." [GOC:ai] +subset: gosubset_prok +synonym: "activation of helicase activity" NARROW [] +synonym: "stimulation of helicase activity" NARROW [] +synonym: "up regulation of helicase activity" EXACT [] +synonym: "up-regulation of helicase activity" EXACT [] +synonym: "upregulation of helicase activity" EXACT [] +is_a: GO:0051095 ! regulation of helicase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0051097 +name: negative regulation of helicase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a helicase." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of helicase activity" EXACT [] +synonym: "down-regulation of helicase activity" EXACT [] +synonym: "downregulation of helicase activity" EXACT [] +synonym: "inhibition of helicase activity" NARROW [] +is_a: GO:0051095 ! regulation of helicase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0051098 +name: regulation of binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] +subset: gosubset_prok +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0051099 +name: positive regulation of binding +namespace: biological_process +def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] +subset: gosubset_prok +synonym: "activation of binding" NARROW [] +synonym: "stimulation of binding" NARROW [] +synonym: "up regulation of binding" EXACT [] +synonym: "up-regulation of binding" EXACT [] +synonym: "upregulation of binding" EXACT [] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0051100 +name: negative regulation of binding +namespace: biological_process +def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of binding" EXACT [] +synonym: "down-regulation of binding" EXACT [] +synonym: "downregulation of binding" EXACT [] +synonym: "inhibition of binding" NARROW [] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0051101 +name: regulation of DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA binding, selective interaction with deoxyribonucleic acid." [GOC:ai] +subset: gosubset_prok +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0051102 +name: DNA ligation during DNA recombination +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA recombination." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006266 ! DNA ligation +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0051103 +name: DNA ligation during DNA repair +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA repair." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006266 ! DNA ligation +relationship: part_of GO:0006281 ! DNA repair + +[Term] +id: GO:0051104 +name: DNA ligation during DNA-dependent DNA replication +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA-dependent DNA replication." [GOC:ai] +subset: gosubset_prok +is_a: GO:0006266 ! DNA ligation +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0051105 +name: regulation of DNA ligation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] +subset: gosubset_prok +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006266 ! DNA ligation + +[Term] +id: GO:0051106 +name: positive regulation of DNA ligation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] +subset: gosubset_prok +synonym: "activation of DNA ligation" NARROW [] +synonym: "stimulation of DNA ligation" NARROW [] +synonym: "up regulation of DNA ligation" EXACT [] +synonym: "up-regulation of DNA ligation" EXACT [] +synonym: "upregulation of DNA ligation" EXACT [] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0051105 ! regulation of DNA ligation +relationship: positively_regulates GO:0006266 ! DNA ligation + +[Term] +id: GO:0051107 +name: negative regulation of DNA ligation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of DNA ligation" EXACT [] +synonym: "down-regulation of DNA ligation" EXACT [] +synonym: "downregulation of DNA ligation" EXACT [] +synonym: "inhibition of DNA ligation" NARROW [] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:0051105 ! regulation of DNA ligation +relationship: negatively_regulates GO:0006266 ! DNA ligation + +[Term] +id: GO:0051108 +name: carnitine-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN] +synonym: "carnitine synthetase activity" EXACT [] +synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] +xref: MetaCyc:DCARNCOALIG-RXN +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0051109 +name: crotonobetaine-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN] +synonym: "crotonobetaine-CoA synthase activity" EXACT [] +synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] +xref: MetaCyc:CROTCOALIG-RXN +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0051110 +name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine +namespace: biological_process +def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] +subset: gosubset_prok +xref: RESID:AA0372 +is_a: GO:0051114 ! peptidyl-histidine uridylylation + +[Term] +id: GO:0051111 +name: peptidyl-histidine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371] +subset: gosubset_prok +xref: RESID:AA0371 +is_a: GO:0018117 ! protein amino acid adenylylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0051112 +name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine +namespace: biological_process +def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] +subset: gosubset_prok +xref: RESID:AA0371 +is_a: GO:0051111 ! peptidyl-histidine adenylylation + +[Term] +id: GO:0051113 +name: enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine +namespace: biological_process +def: "The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] +subset: gosubset_prok +xref: RESID:AA0371 +is_a: GO:0018307 ! enzyme active site formation +is_a: GO:0051112 ! peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine + +[Term] +id: GO:0051114 +name: peptidyl-histidine uridylylation +namespace: biological_process +def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372] +subset: gosubset_prok +xref: RESID:AA0372 +is_a: GO:0018177 ! protein amino acid uridylylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0051115 +name: enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine +namespace: biological_process +def: "The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] +subset: gosubset_prok +xref: RESID:AA0372 +is_a: GO:0018307 ! enzyme active site formation +is_a: GO:0051110 ! peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine + +[Term] +id: GO:0051116 +name: cobaltochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + hydrogenobyrinic acid a,c-diamide + Co2+ = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H+." [EC:6.6.1.2] +subset: gosubset_prok +synonym: "CobN-CobST" RELATED [EC:6.6.1.2] +synonym: "CobNST" NARROW [] +synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT [] +synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" EXACT [EC:6.6.1.2] +xref: EC:6.6.1.2 +xref: MetaCyc:R342-RXN +is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes + +[Term] +id: GO:0051117 +name: ATPase binding +namespace: molecular_function +def: "Interacting selectively with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0051118 +name: glucan endo-1,3-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59] +synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.59] +synonym: "cariogenanase activity" EXACT [EC:3.2.1.59] +synonym: "cariogenase activity" EXACT [EC:3.2.1.59] +synonym: "endo-(1->3)-alpha-glucanase activity" EXACT [EC:3.2.1.59] +synonym: "endo-1,3-alpha-D-glucanase activity" EXACT [EC:3.2.1.59] +synonym: "endo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.59] +synonym: "mutanase activity" EXACT [EC:3.2.1.59] +xref: EC:3.2.1.59 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0051119 +name: sugar transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +subset: gosubset_prok +synonym: "sugar/polyol channel activity" NARROW [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0051120 +name: hepoxilin A3 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid [12S-HpETE] = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate [hepoxilin A3]." [PMID:15123652] +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0051121 +name: hepoxilin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652] +subset: gosubset_prok +synonym: "hepoxilin metabolism" EXACT [] +is_a: GO:0006690 ! icosanoid metabolic process + +[Term] +id: GO:0051122 +name: hepoxilin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai] +subset: gosubset_prok +synonym: "hepoxilin anabolism" EXACT [] +synonym: "hepoxilin biosynthesis" EXACT [] +synonym: "hepoxilin formation" EXACT [] +synonym: "hepoxilin synthesis" EXACT [] +is_a: GO:0046456 ! icosanoid biosynthetic process +is_a: GO:0051121 ! hepoxilin metabolic process + +[Term] +id: GO:0051123 +name: transcriptional preinitiation complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the RNA polymerase II promoter." [PMID:10882737] +synonym: "transcription PIC biosynthesis" EXACT [] +synonym: "transcription PIC formation" EXACT [] +synonym: "transcriptional preinitiation complex formation" EXACT [] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0065004 ! protein-DNA complex assembly + +[Term] +id: GO:0051124 +name: synaptic growth at neuromuscular junction +namespace: biological_process +def: "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "cholinergic synaptogenesis" RELATED [] +is_a: GO:0007416 ! synaptogenesis +is_a: GO:0007528 ! neuromuscular junction development +is_a: GO:0048589 ! developmental growth + +[Term] +id: GO:0051125 +name: regulation of actin nucleation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0045010 ! actin nucleation + +[Term] +id: GO:0051126 +name: negative regulation of actin nucleation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] +synonym: "down regulation of actin nucleation" EXACT [] +synonym: "down-regulation of actin nucleation" EXACT [] +synonym: "downregulation of actin nucleation" EXACT [] +synonym: "inhibition of actin nucleation" NARROW [] +is_a: GO:0051125 ! regulation of actin nucleation +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0045010 ! actin nucleation + +[Term] +id: GO:0051127 +name: positive regulation of actin nucleation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] +synonym: "activation of actin nucleation" NARROW [] +synonym: "stimulation of actin nucleation" NARROW [] +synonym: "up regulation of actin nucleation" EXACT [] +synonym: "up-regulation of actin nucleation" EXACT [] +synonym: "upregulation of actin nucleation" EXACT [] +is_a: GO:0051125 ! regulation of actin nucleation +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0045010 ! actin nucleation + +[Term] +id: GO:0051128 +name: regulation of cellular component organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of cell organisation" EXACT [] +synonym: "regulation of cell organization" EXACT [] +synonym: "regulation of cellular component organisation" EXACT [] +synonym: "regulation of cellular component organization and biogenesis" EXACT [] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0016043 ! cellular component organization + +[Term] +id: GO:0051129 +name: negative regulation of cellular component organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of cell organization" EXACT [] +synonym: "down-regulation of cell organization" EXACT [] +synonym: "downregulation of cell organization" EXACT [] +synonym: "inhibition of cell organization and biogenesis" NARROW [] +synonym: "negative regulation of cell organisation" EXACT [] +synonym: "negative regulation of cellular component organization and biogenesis" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: negatively_regulates GO:0016043 ! cellular component organization + +[Term] +id: GO:0051130 +name: positive regulation of cellular component organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] +synonym: "activation of cell organization" NARROW [] +synonym: "positive regulation of cell organisation" EXACT [] +synonym: "positive regulation of cellular component organization and biogenesis" EXACT [] +synonym: "stimulation of cell organization" NARROW [] +synonym: "up regulation of cell organization and biogenesis" EXACT [] +synonym: "up-regulation of cell organization" EXACT [] +synonym: "upregulation of cell organization" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: positively_regulates GO:0016043 ! cellular component organization + +[Term] +id: GO:0051131 +name: chaperone-mediated protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] +subset: gosubset_prok +synonym: "chaperone activity" RELATED [] +synonym: "protein complex assembly, multichaperone pathway" EXACT [] +is_a: GO:0006461 ! protein complex assembly + +[Term] +id: GO:0051132 +name: NK T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments. +synonym: "natural killer T cell activation" EXACT [] +synonym: "natural T cell activation" EXACT [] +synonym: "NK T lymphocyte activation" EXACT [] +synonym: "NK T-cell activation" EXACT [] +synonym: "NK T-lymphocyte activation" EXACT [] +synonym: "NKT cell activation" EXACT [] +synonym: "NT cell activation" EXACT [] +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0051133 +name: regulation of NK T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "regulation of natural killer T cell activation" EXACT [] +synonym: "regulation of natural T cell activation" EXACT [] +synonym: "regulation of NK T lymphocyte activation" EXACT [] +synonym: "regulation of NK T-cell activation" EXACT [] +synonym: "regulation of NK T-lymphocyte activation" EXACT [] +synonym: "regulation of NKT cell activation" EXACT [] +synonym: "regulation of NT cell activation" EXACT [] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0051132 ! NK T cell activation + +[Term] +id: GO:0051134 +name: negative regulation of NK T cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "down regulation of NK T cell activation" EXACT [] +synonym: "down-regulation of NK T cell activation" EXACT [] +synonym: "downregulation of NK T cell activation" EXACT [] +synonym: "inhibition of NK T cell activation" NARROW [] +synonym: "negative regulation of natural killer T cell activation" EXACT [] +synonym: "negative regulation of natural T cell activation" EXACT [] +synonym: "negative regulation of NK T lymphocyte activation" EXACT [] +synonym: "negative regulation of NK T-cell activation" EXACT [] +synonym: "negative regulation of NK T-lymphocyte activation" EXACT [] +synonym: "negative regulation of NKT cell activation" EXACT [] +synonym: "negative regulation of NT cell activation" EXACT [] +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:0051133 ! regulation of NK T cell activation +relationship: negatively_regulates GO:0051132 ! NK T cell activation + +[Term] +id: GO:0051135 +name: positive regulation of NK T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "activation of NK T cell activation" NARROW [] +synonym: "positive regulation of natural killer T cell activation" EXACT [] +synonym: "positive regulation of natural T cell activation" EXACT [] +synonym: "positive regulation of NK T lymphocyte activation" EXACT [] +synonym: "positive regulation of NK T-cell activation" EXACT [] +synonym: "positive regulation of NK T-lymphocyte activation" EXACT [] +synonym: "positive regulation of NKT cell activation" EXACT [] +synonym: "positive regulation of NT cell activation" EXACT [] +synonym: "stimulation of NK T cell activation" NARROW [] +synonym: "up regulation of NK T cell activation" EXACT [] +synonym: "up-regulation of NK T cell activation" EXACT [] +synonym: "upregulation of NK T cell activation" EXACT [] +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:0051133 ! regulation of NK T cell activation +relationship: positively_regulates GO:0051132 ! NK T cell activation + +[Term] +id: GO:0051136 +name: regulation of NK T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "regulation of natural killer T cell differentiation" EXACT [] +synonym: "regulation of natural T cell differentiation" EXACT [] +synonym: "regulation of NK T lymphocyte differentiation" EXACT [] +synonym: "regulation of NK T-cell differentiation" EXACT [] +synonym: "regulation of NK T-lymphocyte differentiation" EXACT [] +synonym: "regulation of NKT cell differentiation" EXACT [] +synonym: "regulation of NT cell differentiation" EXACT [] +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: regulates GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0051137 +name: negative regulation of NK T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "down regulation of NK T cell differentiation" EXACT [] +synonym: "down-regulation of NK T cell differentiation" EXACT [] +synonym: "downregulation of NK T cell differentiation" EXACT [] +synonym: "inhibition of NK T cell differentiation" NARROW [] +synonym: "negative regulation of natural killer T cell differentiation" EXACT [] +synonym: "negative regulation of natural T cell differentiation" EXACT [] +synonym: "negative regulation of NK T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of NK T-cell differentiation" EXACT [] +synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of NKT cell differentiation" EXACT [] +synonym: "negative regulation of NT cell differentiation" EXACT [] +is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation +is_a: GO:0051136 ! regulation of NK T cell differentiation +relationship: negatively_regulates GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0051138 +name: positive regulation of NK T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "activation of NK T cell differentiation" NARROW [] +synonym: "positive regulation of natural killer T cell differentiation" EXACT [] +synonym: "positive regulation of natural T cell differentiation" EXACT [] +synonym: "positive regulation of NK T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of NK T-cell differentiation" EXACT [] +synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of NKT cell differentiation" EXACT [] +synonym: "positive regulation of NT cell differentiation" EXACT [] +synonym: "stimulation of NK T cell differentiation" NARROW [] +synonym: "up regulation of NK T cell differentiation" EXACT [] +synonym: "up-regulation of NK T cell differentiation" EXACT [] +synonym: "upregulation of NK T cell differentiation" EXACT [] +is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation +is_a: GO:0051136 ! regulation of NK T cell differentiation +relationship: positively_regulates GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0051139 +name: metal ion:hydrogen antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg] +subset: gosubset_prok +synonym: "metal ion:proton antiporter activity" EXACT [] +is_a: GO:0015299 ! solute:hydrogen antiporter activity + +[Term] +id: GO:0051140 +name: regulation of NK T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "regulation of natural killer T cell proliferation" EXACT [] +synonym: "regulation of natural T cell proliferation" EXACT [] +synonym: "regulation of NK T lymphocyte proliferation" EXACT [] +synonym: "regulation of NK T-cell proliferation" EXACT [] +synonym: "regulation of NK T-lymphocyte proliferation" EXACT [] +synonym: "regulation of NKT cell proliferation" EXACT [] +synonym: "regulation of NT cell proliferation" EXACT [] +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +relationship: regulates GO:0001866 ! NK T cell proliferation + +[Term] +id: GO:0051141 +name: negative regulation of NK T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "down regulation of NK T cell proliferation" EXACT [] +synonym: "down-regulation of NK T cell proliferation" EXACT [] +synonym: "downregulation of NK T cell proliferation" EXACT [] +synonym: "inhibition of NK T cell proliferation" NARROW [] +synonym: "negative regulation of natural killer T cell proliferation" EXACT [] +synonym: "negative regulation of natural T cell proliferation" EXACT [] +synonym: "negative regulation of NK T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of NK T-cell proliferation" EXACT [] +synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT [] +synonym: "negative regulation of NKT cell proliferation" EXACT [] +synonym: "negative regulation of NT cell proliferation" EXACT [] +is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation +is_a: GO:0051140 ! regulation of NK T cell proliferation +relationship: negatively_regulates GO:0001866 ! NK T cell proliferation + +[Term] +id: GO:0051142 +name: positive regulation of NK T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426] +synonym: "activation of NK T cell proliferation" NARROW [] +synonym: "positive regulation of natural killer T cell proliferation" EXACT [] +synonym: "positive regulation of natural T cell proliferation" EXACT [] +synonym: "positive regulation of NK T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of NK T-cell proliferation" EXACT [] +synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT [] +synonym: "positive regulation of NKT cell proliferation" EXACT [] +synonym: "positive regulation of NT cell proliferation" EXACT [] +synonym: "stimulation of NK T cell proliferation" NARROW [] +synonym: "up regulation of NK T cell proliferation" EXACT [] +synonym: "up-regulation of NK T cell proliferation" EXACT [] +synonym: "upregulation of NK T cell proliferation" EXACT [] +is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation +is_a: GO:0051140 ! regulation of NK T cell proliferation +relationship: positively_regulates GO:0001866 ! NK T cell proliferation + +[Term] +id: GO:0051143 +name: propanediol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [http://www.onelook.com] +subset: gosubset_prok +synonym: "1,2-dihydroxypropane metabolic process" EXACT [] +synonym: "1,2-dihydroxypropane metabolism" EXACT [] +synonym: "propanediol metabolism" EXACT [] +synonym: "propylene glycol metabolic process" EXACT [] +synonym: "propylene glycol metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:0051144 +name: propanediol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai] +subset: gosubset_prok +synonym: "1,2-dihydroxypropane catabolic process" EXACT [] +synonym: "1,2-dihydroxypropane catabolism" EXACT [] +synonym: "propanediol breakdown" EXACT [] +synonym: "propanediol catabolism" EXACT [] +synonym: "propanediol degradation" EXACT [] +synonym: "propylene glycol catabolic process" EXACT [] +synonym: "propylene glycol catabolism" EXACT [] +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0051143 ! propanediol metabolic process + +[Term] +id: GO:0051145 +name: smooth muscle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] +synonym: "nonstriated muscle cell differentiation" EXACT [] +is_a: GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051146 +name: striated muscle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] +synonym: "voluntary muscle cell differentiation" NARROW [] +is_a: GO:0042692 ! muscle cell differentiation +relationship: part_of GO:0014706 ! striated muscle development + +[Term] +id: GO:0051147 +name: regulation of muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051148 +name: negative regulation of muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] +synonym: "down regulation of muscle cell differentiation" EXACT [] +synonym: "down-regulation of muscle cell differentiation" EXACT [] +synonym: "downregulation of muscle cell differentiation" EXACT [] +synonym: "inhibition of muscle cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: negatively_regulates GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051149 +name: positive regulation of muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] +synonym: "activation of muscle cell differentiation" NARROW [] +synonym: "stimulation of muscle cell differentiation" NARROW [] +synonym: "up regulation of muscle cell differentiation" EXACT [] +synonym: "up-regulation of muscle cell differentiation" EXACT [] +synonym: "upregulation of muscle cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: positively_regulates GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051150 +name: regulation of smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: regulates GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:0051151 +name: negative regulation of smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] +synonym: "down regulation of smooth muscle cell differentiation" EXACT [] +synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] +synonym: "downregulation of smooth muscle cell differentiation" EXACT [] +synonym: "inhibition of smooth muscle cell differentiation" NARROW [] +is_a: GO:0051148 ! negative regulation of muscle cell differentiation +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:0051152 +name: positive regulation of smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] +synonym: "activation of smooth muscle cell differentiation" NARROW [] +synonym: "stimulation of smooth muscle cell differentiation" NARROW [] +synonym: "up regulation of smooth muscle cell differentiation" EXACT [] +synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] +synonym: "upregulation of smooth muscle cell differentiation" EXACT [] +is_a: GO:0051149 ! positive regulation of muscle cell differentiation +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:0051153 +name: regulation of striated muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] +is_a: GO:0016202 ! regulation of striated muscle development +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: regulates GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0051154 +name: negative regulation of striated muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] +synonym: "down regulation of striated muscle cell differentiation" EXACT [] +synonym: "down-regulation of striated muscle cell differentiation" EXACT [] +synonym: "downregulation of striated muscle cell differentiation" EXACT [] +synonym: "inhibition of striated muscle cell differentiation" NARROW [] +is_a: GO:0051148 ! negative regulation of muscle cell differentiation +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0051155 +name: positive regulation of striated muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] +synonym: "activation of striated muscle cell differentiation" NARROW [] +synonym: "stimulation of striated muscle cell differentiation" NARROW [] +synonym: "up regulation of striated muscle cell differentiation" EXACT [] +synonym: "up-regulation of striated muscle cell differentiation" EXACT [] +synonym: "upregulation of striated muscle cell differentiation" EXACT [] +is_a: GO:0051149 ! positive regulation of muscle cell differentiation +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0051156 +name: glucose 6-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] +subset: gosubset_prok +synonym: "glucose 6-phosphate metabolism" EXACT [] +xref: Reactome:170810 +xref: Reactome:170822 +xref: Reactome:170824 +xref: Reactome:208670 +xref: Reactome:209899 +xref: Reactome:211743 +xref: Reactome:221577 +xref: Reactome:230178 +xref: Reactome:235534 +xref: Reactome:236576 +xref: Reactome:238156 +xref: Reactome:244792 +is_a: GO:0006006 ! glucose metabolic process + +[Term] +id: GO:0051157 +name: arabitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "arabitol breakdown" EXACT [] +synonym: "arabitol catabolism" EXACT [] +synonym: "arabitol degradation" EXACT [] +is_a: GO:0019527 ! pentitol catabolic process +is_a: GO:0051161 ! arabitol metabolic process + +[Term] +id: GO:0051158 +name: L-arabitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-arabitol breakdown" EXACT [] +synonym: "L-arabitol catabolism" EXACT [] +synonym: "L-arabitol degradation" EXACT [] +is_a: GO:0051157 ! arabitol catabolic process +is_a: GO:0051162 ! L-arabitol metabolic process + +[Term] +id: GO:0051159 +name: D-arabitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-arabitol breakdown" EXACT [] +synonym: "D-arabitol catabolism" EXACT [] +synonym: "D-arabitol degradation" EXACT [] +is_a: GO:0051157 ! arabitol catabolic process +is_a: GO:0051163 ! D-arabitol metabolic process + +[Term] +id: GO:0051160 +name: L-xylitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai] +subset: gosubset_prok +synonym: "L-xylitol breakdown" EXACT [] +synonym: "L-xylitol catabolism" EXACT [] +synonym: "L-xylitol degradation" EXACT [] +is_a: GO:0019527 ! pentitol catabolic process +is_a: GO:0051164 ! L-xylitol metabolic process + +[Term] +id: GO:0051161 +name: arabitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "arabitol metabolism" EXACT [] +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0051162 +name: L-arabitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "L-arabitol metabolism" EXACT [] +is_a: GO:0051161 ! arabitol metabolic process + +[Term] +id: GO:0051163 +name: D-arabitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "D-arabitol metabolism" EXACT [] +is_a: GO:0051161 ! arabitol metabolic process + +[Term] +id: GO:0051164 +name: L-xylitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai, http://www.onelook.com] +subset: gosubset_prok +synonym: "L-xylitol metabolism" EXACT [] +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0051165 +name: 2,5-dihydroxypyridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [GOC:ai] +subset: gosubset_prok +synonym: "2,5-dihydroxypyridine metabolism" EXACT [] +is_a: GO:0019507 ! pyridine metabolic process + +[Term] +id: GO:0051166 +name: 2,5-dihydroxypyridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [GOC:ai] +subset: gosubset_prok +synonym: "2,5-dihydroxypyridine breakdown" EXACT [] +synonym: "2,5-dihydroxypyridine catabolism" EXACT [] +synonym: "2,5-dihydroxypyridine degradation" EXACT [] +is_a: GO:0046221 ! pyridine catabolic process +is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process + +[Term] +id: GO:0051167 +name: xylulose 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +subset: gosubset_prok +synonym: "D-xylulose 5-phosphate metabolic process" EXACT [] +synonym: "D-xylulose 5-phosphate metabolism" EXACT [] +synonym: "D-xylulose-5-phosphate metabolic process" EXACT [] +synonym: "D-xylulose-5-phosphate metabolism" EXACT [] +synonym: "xylulose 5-phosphate metabolism" EXACT [] +synonym: "xylulose-5-phosphate metabolic process" EXACT [] +synonym: "xylulose-5-phosphate metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0051168 +name: nuclear export +namespace: biological_process +def: "The directed movement of substances out of the nucleus." [GOC:ai] +synonym: "export from nucleus" EXACT [] +synonym: "nucleus export" EXACT [] +synonym: "substance nuclear export" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0051169 +name: nuclear transport +namespace: biological_process +def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] +synonym: "nucleus transport" EXACT [] +xref: Reactome:162590 +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0051170 +name: nuclear import +namespace: biological_process +def: "The directed movement of substances into the nucleus." [GOC:ai] +synonym: "import into nucleus" EXACT [] +synonym: "nucleus import" EXACT [] +synonym: "substance nuclear import" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0051171 +name: regulation of nitrogen compound metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] +subset: gosubset_prok +synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] +synonym: "regulation of nitrogen metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0051172 +name: negative regulation of nitrogen compound metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] +synonym: "down regulation of nitrogen metabolic process" EXACT [] +synonym: "down-regulation of nitrogen metabolic process" EXACT [] +synonym: "downregulation of nitrogen metabolic process" EXACT [] +synonym: "inhibition of nitrogen metabolic process" NARROW [] +synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] +synonym: "negative regulation of nitrogen metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0051173 +name: positive regulation of nitrogen compound metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] +synonym: "activation of nitrogen metabolic process" NARROW [] +synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] +synonym: "positive regulation of nitrogen metabolism" EXACT [] +synonym: "stimulation of nitrogen metabolic process" NARROW [] +synonym: "up regulation of nitrogen metabolic process" EXACT [] +synonym: "up-regulation of nitrogen metabolic process" EXACT [] +synonym: "upregulation of nitrogen metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0051174 +name: regulation of phosphorus metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of phosphorus metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0051175 +name: negative regulation of sulfur metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of sulfur metabolic process" EXACT [] +synonym: "down-regulation of sulfur metabolic process" EXACT [] +synonym: "downregulation of sulfur metabolic process" EXACT [] +synonym: "inhibition of sulfur metabolic process" NARROW [] +synonym: "negative regulation of sulfur metabolism" EXACT [] +synonym: "negative regulation of sulphur metabolic process" EXACT [] +synonym: "negative regulation of sulphur metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: negatively_regulates GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0051176 +name: positive regulation of sulfur metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] +subset: gosubset_prok +synonym: "activation of sulfur metabolic process" NARROW [] +synonym: "positive regulation of sulfur metabolism" EXACT [] +synonym: "positive regulation of sulphur metabolic process" EXACT [] +synonym: "positive regulation of sulphur metabolism" EXACT [] +synonym: "stimulation of sulfur metabolic process" NARROW [] +synonym: "up regulation of sulfur metabolic process" EXACT [] +synonym: "up-regulation of sulfur metabolic process" EXACT [] +synonym: "upregulation of sulfur metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: positively_regulates GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0051177 +name: meiotic sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] +is_a: GO:0007062 ! sister chromatid cohesion +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051178 +name: meiotic chromosome decondensation +namespace: biological_process +def: "The cell cycle process whereby chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051312 ! chromosome decondensation +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051179 +name: localization +namespace: biological_process +def: "Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "establishment and maintenance of cellular component location" NARROW [] +synonym: "establishment and maintenance of localization" EXACT [] +synonym: "establishment and maintenance of position" EXACT [] +synonym: "establishment and maintenance of substance location" NARROW [] +synonym: "establishment and maintenance of substrate location" NARROW [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0051180 +name: vitamin transport +namespace: biological_process +def: "The directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "vitamin or cofactor transport" BROAD [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0051181 +name: cofactor transport +namespace: biological_process +def: "The directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "vitamin or cofactor transport" BROAD [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0051182 +name: coenzyme transport +namespace: biological_process +def: "The directed movement of a coenzyme into, out of, within or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +is_a: GO:0051181 ! cofactor transport + +[Term] +id: GO:0051183 +name: vitamin transporter activity +namespace: molecular_function +def: "Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin or cofactor transporter activity" BROAD [] +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0051184 +name: cofactor transporter activity +namespace: molecular_function +def: "Enables the directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +subset: gosubset_prok +synonym: "vitamin or cofactor transporter activity" BROAD [] +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0051185 +name: coenzyme transporter activity +namespace: molecular_function +def: "Enables the directed movement of a coenzyme into, out of, within or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0051186 +name: cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] +subset: goslim_pir +subset: goslim_yeast +subset: gosubset_prok +synonym: "cofactor metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0051187 +name: cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +subset: gosubset_prok +synonym: "cofactor breakdown" EXACT [] +synonym: "cofactor catabolism" EXACT [] +synonym: "cofactor degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051188 +name: cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +subset: gosubset_prok +synonym: "cofactor anabolism" EXACT [] +synonym: "cofactor biosynthesis" EXACT [] +synonym: "cofactor formation" EXACT [] +synonym: "cofactor synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051189 +name: prosthetic group metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "coenzyme and prosthetic group metabolism" BROAD [] +synonym: "prosthetic group metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +relationship: part_of GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0051190 +name: prosthetic group catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] +subset: gosubset_prok +synonym: "coenzyme and prosthetic group catabolic process" BROAD [] +synonym: "coenzyme and prosthetic group catabolism" BROAD [] +synonym: "prosthetic group breakdown" EXACT [] +synonym: "prosthetic group catabolism" EXACT [] +synonym: "prosthetic group degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0051189 ! prosthetic group metabolic process +relationship: part_of GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0051191 +name: prosthetic group biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] +subset: gosubset_prok +synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] +synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] +synonym: "prosthetic group anabolism" EXACT [] +synonym: "prosthetic group biosynthesis" EXACT [] +synonym: "prosthetic group formation" EXACT [] +synonym: "prosthetic group synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0051189 ! prosthetic group metabolic process +relationship: part_of GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0051192 +name: prosthetic group binding +namespace: molecular_function +def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0051193 +name: regulation of cofactor metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of cofactor metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051194 +name: positive regulation of cofactor metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +subset: gosubset_prok +synonym: "activation of cofactor metabolic process" NARROW [] +synonym: "positive regulation of cofactor metabolism" EXACT [] +synonym: "stimulation of cofactor metabolic process" NARROW [] +synonym: "up regulation of cofactor metabolic process" EXACT [] +synonym: "up-regulation of cofactor metabolic process" EXACT [] +synonym: "upregulation of cofactor metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051193 ! regulation of cofactor metabolic process +relationship: positively_regulates GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051195 +name: negative regulation of cofactor metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of cofactor metabolic process" EXACT [] +synonym: "down-regulation of cofactor metabolic process" EXACT [] +synonym: "downregulation of cofactor metabolic process" EXACT [] +synonym: "inhibition of cofactor metabolic process" NARROW [] +synonym: "negative regulation of cofactor metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051193 ! regulation of cofactor metabolic process +relationship: negatively_regulates GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051196 +name: regulation of coenzyme metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "regulation of coenzyme metabolism" EXACT [] +is_a: GO:0051193 ! regulation of cofactor metabolic process +relationship: regulates GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0051197 +name: positive regulation of coenzyme metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +subset: gosubset_prok +synonym: "activation of coenzyme metabolic process" NARROW [] +synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "positive regulation of coenzyme metabolism" EXACT [] +synonym: "stimulation of coenzyme metabolic process" NARROW [] +synonym: "up regulation of coenzyme metabolic process" EXACT [] +synonym: "up-regulation of coenzyme metabolic process" EXACT [] +synonym: "upregulation of coenzyme metabolic process" EXACT [] +is_a: GO:0051194 ! positive regulation of cofactor metabolic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: positively_regulates GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0051198 +name: negative regulation of coenzyme metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of coenzyme metabolic process" EXACT [] +synonym: "down-regulation of coenzyme metabolic process" EXACT [] +synonym: "downregulation of coenzyme metabolic process" EXACT [] +synonym: "inhibition of coenzyme metabolic process" NARROW [] +synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "negative regulation of coenzyme metabolism" EXACT [] +is_a: GO:0051195 ! negative regulation of cofactor metabolic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process + +[Term] +id: GO:0051199 +name: regulation of prosthetic group metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "regulation of prosthetic group metabolism" EXACT [] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0051200 +name: positive regulation of prosthetic group metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] +subset: gosubset_prok +synonym: "activation of prosthetic group metabolic process" NARROW [] +synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "positive regulation of prosthetic group metabolism" EXACT [] +synonym: "stimulation of prosthetic group metabolic process" NARROW [] +synonym: "up regulation of prosthetic group metabolic process" EXACT [] +synonym: "up-regulation of prosthetic group metabolic process" EXACT [] +synonym: "upregulation of prosthetic group metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051199 ! regulation of prosthetic group metabolic process +relationship: positively_regulates GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0051201 +name: negative regulation of prosthetic group metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of prosthetic group metabolic process" EXACT [] +synonym: "down-regulation of prosthetic group metabolic process" EXACT [] +synonym: "downregulation of prosthetic group metabolic process" EXACT [] +synonym: "inhibition of prosthetic group metabolic process" NARROW [] +synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "negative regulation of prosthetic group metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051199 ! regulation of prosthetic group metabolic process +relationship: negatively_regulates GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0051202 +name: phytochromobilin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553] +subset: gosubset_prok +synonym: "phytochromobilin metabolism" EXACT [] +is_a: GO:0051186 ! cofactor metabolic process + +[Term] +id: GO:0051203 +name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde +namespace: biological_process +def: "The posttranslational reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373] +comment: See also UniProtKB:P04160. +subset: gosubset_prok +synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT [] +synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT [] +xref: RESID:AA0373 +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0051204 +name: protein insertion into mitochondrial membrane +namespace: biological_process +def: "The process by which a protein is incorporated into a mitochondrial membrane." [GOC:ai] +synonym: "integral mitochondrial membrane protein localization" EXACT [] +synonym: "integral mitochondrial membrane protein positioning" EXACT [] +synonym: "localization of protein in mitochondrial membrane" EXACT [] +synonym: "positioning of protein in mitochondrial membrane" EXACT [] +synonym: "protein insertion into mitochondrion membrane" EXACT [] +synonym: "protein-mitochondrial membrane insertion" EXACT [] +synonym: "protein-mitochondrion membrane insertion" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization +is_a: GO:0051205 ! protein insertion into membrane + +[Term] +id: GO:0051205 +name: protein insertion into membrane +namespace: biological_process +def: "The process by which a protein is incorporated into a biological membrane." [GOC:ai] +subset: gosubset_prok +synonym: "integral membrane protein localization" EXACT [] +synonym: "integral membrane protein positioning" EXACT [] +synonym: "membrane protein localization" EXACT [] +synonym: "membrane protein positioning" EXACT [] +synonym: "protein-membrane insertion" EXACT [] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0051668 ! localization within membrane +relationship: part_of GO:0016044 ! membrane organization + +[Term] +id: GO:0051206 +name: silicate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai] +subset: gosubset_prok +synonym: "silicate metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0051207 +name: silicic acid transport +namespace: biological_process +def: "The directed movement of silicic acid into, out of, within or between cells. Silicic acid, Si(OH)4, is a hydrated form of silicon dioxide that occurs in nature; it is insoluble in water or acids except hydrofluoric acid." [GOC:ai, http://www.onelook.com] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0051208 +name: sequestering of calcium ion +namespace: biological_process +def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "calcium ion (Ca2+) retention" EXACT [] +synonym: "calcium ion (Ca2+) sequestering" EXACT [] +synonym: "calcium ion (Ca2+) sequestration" EXACT [] +synonym: "calcium ion (Ca2+) storage" EXACT [] +synonym: "calcium ion storage activity" RELATED [] +synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED [] +synonym: "retention of calcium ion (Ca2+)" EXACT [] +synonym: "sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +relationship: part_of GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0051209 +name: release of sequestered calcium ion into cytosol +namespace: biological_process +def: "The process by which calcium ions sequestered in the endoplasmic reticulum or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung] +synonym: "calcium ion (Ca2+) mobilization" BROAD [] +synonym: "calcium mobilization" BROAD [] +synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "release of stored calcium ion (Ca2+)" BROAD [] +synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration +is_a: GO:0051283 ! negative regulation of sequestering of calcium ion + +[Term] +id: GO:0051210 +name: isotropic cell growth +namespace: biological_process +def: "The process by which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jic] +synonym: "uniform cell growth" RELATED [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0051211 +name: anisotropic cell growth +namespace: biological_process +def: "The process by which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai] +synonym: "non-isotropic cell growth" EXACT [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0051212 +name: vanadium ion binding +namespace: molecular_function +def: "Interacting selectively with vanadium (V) ions." [GOC:ai] +subset: gosubset_prok +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0051213 +name: dioxygenase activity +namespace: molecular_function +def: "Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate." [http://www.onelook.com/] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0051214 +name: RNA virus induced gene silencing +namespace: biological_process +def: "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191] +synonym: "RNA VIGS" EXACT [] +synonym: "RNA virus-induced gene silencing" EXACT [] +is_a: GO:0009616 ! virus induced gene silencing + +[Term] +id: GO:0051215 +name: DNA virus induced gene silencing +namespace: biological_process +def: "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191] +synonym: "DNA VIGS" EXACT [] +synonym: "DNA virus-induced gene silencing" EXACT [] +is_a: GO:0009616 ! virus induced gene silencing + +[Term] +id: GO:0051216 +name: cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [http://www.onelook.com] +synonym: "cartilage biogenesis" EXACT [] +synonym: "cartilage biosynthesis" EXACT [] +synonym: "cartilage formation" EXACT [] +synonym: "chondrogenesis" EXACT [] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0001501 ! skeletal system development + +[Term] +id: GO:0051217 +name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375] +subset: gosubset_prok +xref: RESID:AA0375 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0051218 +name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) +namespace: biological_process +def: "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376] +subset: gosubset_prok +xref: RESID:AA02376 +is_a: GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex +is_a: GO:0050844 ! peptidyl-selenocysteine modification + +[Term] +id: GO:0051219 +name: phosphoprotein binding +namespace: molecular_function +def: "Interacting selectively with a phosphorylated protein." [GOC:ai] +synonym: "phosphorylated protein binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051220 +name: cytoplasmic sequestering of protein +namespace: biological_process +def: "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai] +synonym: "cytoplasmic retention of protein" EXACT [] +synonym: "cytoplasmic sequestration of protein" EXACT [] +synonym: "cytoplasmic storage of protein" EXACT [] +synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] +synonym: "retention of protein in cytoplasm" EXACT [] +synonym: "sequestering of protein in cytoplasm" EXACT [] +synonym: "sequestration of protein in cytoplasm" EXACT [] +synonym: "storage of protein in cytoplasm" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +is_a: GO:0051224 ! negative regulation of protein transport + +[Term] +id: GO:0051221 +name: tungsten incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai] +subset: gosubset_prok +synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0051222 +name: positive regulation of protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells." [GOC:ai] +synonym: "activation of protein transport" NARROW [] +synonym: "stimulation of protein transport" NARROW [] +synonym: "up regulation of protein transport" EXACT [] +synonym: "up-regulation of protein transport" EXACT [] +synonym: "upregulation of protein transport" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051223 ! regulation of protein transport +relationship: positively_regulates GO:0015031 ! protein transport + +[Term] +id: GO:0051223 +name: regulation of protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells." [GOC:ai] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015031 ! protein transport + +[Term] +id: GO:0051224 +name: negative regulation of protein transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells." [GOC:ai] +synonym: "down regulation of protein transport" EXACT [] +synonym: "down-regulation of protein transport" EXACT [] +synonym: "downregulation of protein transport" EXACT [] +synonym: "inhibition of protein transport" NARROW [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051223 ! regulation of protein transport +relationship: negatively_regulates GO:0015031 ! protein transport + +[Term] +id: GO:0051225 +name: spindle assembly +namespace: biological_process +alt_id: GO:0051226 +alt_id: GO:0051227 +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:mtg_sensu, GOC:rg, GOC:tb] +synonym: "bipolar spindle biosynthesis" EXACT [] +synonym: "bipolar spindle formation" EXACT [] +synonym: "meiotic spindle assembly" NARROW [] +synonym: "meiotic spindle biogenesis" NARROW [] +synonym: "meiotic spindle biosynthesis" NARROW [] +synonym: "meiotic spindle formation" NARROW [] +synonym: "mitotic spindle assembly" NARROW [] +synonym: "mitotic spindle biogenesis" NARROW [] +synonym: "mitotic spindle biosynthesis" NARROW [] +synonym: "mitotic spindle formation" NARROW [] +synonym: "spindle assembly involved in meiosis" NARROW [] +synonym: "spindle assembly involved in mitosis" NARROW [] +synonym: "spindle biogenesis" EXACT [] +synonym: "spindle biogenesis involved in meiosis" NARROW [] +synonym: "spindle biogenesis involved in mitosis" NARROW [] +synonym: "spindle biosynthesis" EXACT [] +synonym: "spindle formation" EXACT [] +synonym: "spindle formation involved in meiosis" NARROW [] +synonym: "spindle formation involved in mitosis" NARROW [] +is_a: GO:0007051 ! spindle organization +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0051228 +name: mitotic spindle disassembly +namespace: biological_process +def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai] +synonym: "mitotic spindle breakdown" EXACT [] +synonym: "mitotic spindle catabolism" EXACT [] +synonym: "mitotic spindle degradation" EXACT [] +synonym: "spindle breakdown during mitosis" EXACT [] +synonym: "spindle degradation during mitosis" EXACT [] +synonym: "spindle disassembly during mitosis" EXACT [] +is_a: GO:0007052 ! mitotic spindle organization +is_a: GO:0051230 ! spindle disassembly + +[Term] +id: GO:0051229 +name: meiotic spindle disassembly +namespace: biological_process +def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai] +synonym: "meiotic spindle breakdown" EXACT [] +synonym: "meiotic spindle catabolism" EXACT [] +synonym: "meiotic spindle degradation" EXACT [] +synonym: "spindle breakdown during meiosis" EXACT [] +synonym: "spindle degradation during meiosis" EXACT [] +synonym: "spindle disassembly during meiosis" EXACT [] +is_a: GO:0000212 ! meiotic spindle organization +is_a: GO:0051230 ! spindle disassembly + +[Term] +id: GO:0051230 +name: spindle disassembly +namespace: biological_process +def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai] +synonym: "spindle breakdown" EXACT [] +synonym: "spindle catabolism" EXACT [] +synonym: "spindle degradation" EXACT [] +is_a: GO:0007051 ! spindle organization +is_a: GO:0022411 ! cellular component disassembly + +[Term] +id: GO:0051231 +name: spindle elongation +namespace: biological_process +def: "The cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:ai] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007051 ! spindle organization + +[Term] +id: GO:0051232 +name: meiotic spindle elongation +namespace: biological_process +def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai] +synonym: "spindle elongation during meiosis" EXACT [] +is_a: GO:0051231 ! spindle elongation +relationship: part_of GO:0000212 ! meiotic spindle organization + +[Term] +id: GO:0051233 +name: spindle midzone +namespace: cellular_component +def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] +synonym: "spindle equator" EXACT [] +is_a: GO:0044430 ! cytoskeletal part +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0051234 +name: establishment of localization +namespace: biological_process +def: "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0008150 ! biological_process +relationship: part_of GO:0051179 ! localization + +[Term] +id: GO:0051235 +name: maintenance of location +namespace: biological_process +def: "Any process by which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "retention" NARROW [] +synonym: "sequestering" NARROW [] +synonym: "storage" NARROW [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0051179 ! localization + +[Term] +id: GO:0051236 +name: establishment of RNA localization +namespace: biological_process +def: "The directed movement of RNA to a specific location." [GOC:ai] +synonym: "RNA positioning" EXACT [] +synonym: "RNA recruitment" EXACT [] +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0006403 ! RNA localization + +[Term] +id: GO:0051237 +name: maintenance of RNA location +namespace: biological_process +def: "Any process by which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai] +synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb] +synonym: "RNA retention" EXACT [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0006403 ! RNA localization + +[Term] +id: GO:0051238 +name: sequestering of metal ion +namespace: biological_process +def: "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai] +subset: gosubset_prok +synonym: "metal ion retention" EXACT [] +synonym: "metal ion sequestering" EXACT [] +synonym: "metal ion sequestration" EXACT [] +synonym: "metal ion storage" EXACT [] +synonym: "retention of metal ion" EXACT [] +synonym: "sequestration of metal ion" EXACT [] +synonym: "storage of metal ion" EXACT [] +is_a: GO:0051235 ! maintenance of location + +[Term] +id: GO:0051239 +name: regulation of multicellular organismal process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051240 +name: positive regulation of multicellular organismal process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] +synonym: "activation of multicellular organismal process" NARROW [] +synonym: "stimulation of multicellular organismal process" NARROW [] +synonym: "up regulation of multicellular organismal process" EXACT [] +synonym: "up-regulation of multicellular organismal process" EXACT [] +synonym: "upregulation of multicellular organismal process" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: positively_regulates GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051241 +name: negative regulation of multicellular organismal process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] +synonym: "down regulation of multicellular organismal process" EXACT [] +synonym: "down-regulation of multicellular organismal process" EXACT [] +synonym: "downregulation of multicellular organismal process" EXACT [] +synonym: "inhibition of multicellular organismal process" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: negatively_regulates GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051245 +name: negative regulation of cellular defense response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai] +synonym: "down regulation of cellular defense response" EXACT [] +synonym: "down-regulation of cellular defense response" EXACT [] +synonym: "downregulation of cellular defense response" EXACT [] +synonym: "inhibition of cellular defense response" NARROW [] +synonym: "negative regulation of cellular defence response" EXACT [] +is_a: GO:0010185 ! regulation of cellular defense response +is_a: GO:0031348 ! negative regulation of defense response +relationship: negatively_regulates GO:0006968 ! cellular defense response + +[Term] +id: GO:0051246 +name: regulation of protein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of protein metabolism" EXACT [] +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0019538 ! protein metabolic process + +[Term] +id: GO:0051247 +name: positive regulation of protein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] +subset: gosubset_prok +synonym: "activation of protein metabolic process" NARROW [] +synonym: "positive regulation of protein metabolism" EXACT [] +synonym: "stimulation of protein metabolic process" NARROW [] +synonym: "up regulation of protein metabolic process" EXACT [] +synonym: "up-regulation of protein metabolic process" EXACT [] +synonym: "upregulation of protein metabolic process" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: positively_regulates GO:0019538 ! protein metabolic process + +[Term] +id: GO:0051248 +name: negative regulation of protein metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of protein metabolic process" EXACT [] +synonym: "down-regulation of protein metabolic process" EXACT [] +synonym: "downregulation of protein metabolic process" EXACT [] +synonym: "inhibition of protein metabolic process" NARROW [] +synonym: "negative regulation of protein metabolism" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: negatively_regulates GO:0019538 ! protein metabolic process + +[Term] +id: GO:0051249 +name: regulation of lymphocyte activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0051250 +name: negative regulation of lymphocyte activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] +synonym: "down regulation of lymphocyte activation" EXACT [] +synonym: "down-regulation of lymphocyte activation" EXACT [] +synonym: "downregulation of lymphocyte activation" EXACT [] +synonym: "inhibition of lymphocyte activation" NARROW [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: negatively_regulates GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0051251 +name: positive regulation of lymphocyte activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] +synonym: "activation of lymphocyte activation" NARROW [] +synonym: "stimulation of lymphocyte activation" NARROW [] +synonym: "up regulation of lymphocyte activation" EXACT [] +synonym: "up-regulation of lymphocyte activation" EXACT [] +synonym: "upregulation of lymphocyte activation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: positively_regulates GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0051252 +name: regulation of RNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of RNA metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0051253 +name: negative regulation of RNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of RNA metabolic process" EXACT [] +synonym: "down-regulation of RNA metabolic process" EXACT [] +synonym: "downregulation of RNA metabolic process" EXACT [] +synonym: "inhibition of RNA metabolic process" NARROW [] +synonym: "negative regulation of RNA metabolism" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: negatively_regulates GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0051254 +name: positive regulation of RNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] +subset: gosubset_prok +synonym: "activation of RNA metabolic process" NARROW [] +synonym: "positive regulation of RNA metabolism" EXACT [] +synonym: "stimulation of RNA metabolic process" NARROW [] +synonym: "up regulation of RNA metabolic process" EXACT [] +synonym: "up-regulation of RNA metabolic process" EXACT [] +synonym: "upregulation of RNA metabolic process" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: positively_regulates GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0051255 +name: spindle midzone assembly +namespace: biological_process +def: "The cell cycle process whereby aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] +synonym: "spindle midzone biogenesis" EXACT [] +synonym: "spindle midzone biosynthesis" EXACT [] +synonym: "spindle midzone formation" EXACT [] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022402 ! cell cycle process +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0051225 ! spindle assembly + +[Term] +id: GO:0051256 +name: spindle midzone assembly involved in mitosis +namespace: biological_process +def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of mitosis." [GOC:ai, GOC:rg, GOC:tb] +synonym: "mitotic spindle midzone assembly" RELATED [] +synonym: "mitotic spindle midzone biogenesis" EXACT [] +synonym: "mitotic spindle midzone biosynthesis" EXACT [] +synonym: "mitotic spindle midzone formation" EXACT [] +synonym: "spindle midzone biogenesis involved in mitosis" EXACT [] +synonym: "spindle midzone formation involved in mitosis" EXACT [] +is_a: GO:0051255 ! spindle midzone assembly + +[Term] +id: GO:0051257 +name: spindle midzone assembly involved in meiosis +namespace: biological_process +def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of meiosis." [GOC:ai, GOC:rg, GOC:tb] +synonym: "meiotic spindle midzone assembly" RELATED [] +synonym: "meiotic spindle midzone biogenesis" EXACT [] +synonym: "meiotic spindle midzone biosynthesis" EXACT [] +synonym: "meiotic spindle midzone formation" EXACT [] +synonym: "spindle midzone biogenesis involved in meiosis" EXACT [] +synonym: "spindle midzone biosynthesis involved in meiosis" EXACT [] +synonym: "spindle midzone formation involved in meiosis" EXACT [] +is_a: GO:0051255 ! spindle midzone assembly + +[Term] +id: GO:0051258 +name: protein polymerization +namespace: biological_process +def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "protein polymer biosynthesis" EXACT [] +synonym: "protein polymer biosynthetic process" EXACT [] +synonym: "protein polymer formation" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0051259 +name: protein oligomerization +namespace: biological_process +def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] +subset: gosubset_prok +synonym: "protein oligomer assembly" EXACT [] +synonym: "protein oligomer biosynthesis" EXACT [] +synonym: "protein oligomer biosynthetic process" EXACT [] +synonym: "protein oligomer formation" EXACT [] +is_a: GO:0006461 ! protein complex assembly + +[Term] +id: GO:0051260 +name: protein homooligomerization +namespace: biological_process +def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] +subset: gosubset_prok +synonym: "protein homooligomer assembly" EXACT [] +synonym: "protein homooligomer biosynthesis" EXACT [] +synonym: "protein homooligomer biosynthetic process" EXACT [] +synonym: "protein homooligomer formation" EXACT [] +synonym: "protein homooligomerization activity" RELATED [] +is_a: GO:0051259 ! protein oligomerization + +[Term] +id: GO:0051261 +name: protein depolymerization +namespace: biological_process +def: "The process by which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "protein polymer breakdown" EXACT [] +synonym: "protein polymer catabolic process" EXACT [] +synonym: "protein polymer catabolism" EXACT [] +synonym: "protein polymer degradation" EXACT [] +is_a: GO:0043624 ! cellular protein complex disassembly + +[Term] +id: GO:0051262 +name: protein tetramerization +namespace: biological_process +def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] +subset: gosubset_prok +synonym: "protein tetramer assembly" EXACT [] +synonym: "protein tetramer biosynthesis" EXACT [] +synonym: "protein tetramer biosynthetic process" EXACT [] +synonym: "protein tetramer formation" EXACT [] +is_a: GO:0051259 ! protein oligomerization + +[Term] +id: GO:0051263 +name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine +namespace: biological_process +def: "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374] +subset: gosubset_prok +synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT [] +synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT [] +synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT [] +xref: RESID:AA0374 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018350 ! protein amino acid esterification + +[Term] +id: GO:0051264 +name: mono-olein transacylation activity +namespace: molecular_function +def: "Catalysis of the reaction: mono-olein (mono-oleoylglycerol) + mono-olein = diolein (dioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid." [GOC:ai, PMID:15364929] +synonym: "acyl-CoA-independent mono-olein transacylation" EXACT [] +synonym: "MOG transacylation" EXACT [] +synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT [] +synonym: "mono-oleoylglycerol transacylase activity" EXACT [] +synonym: "monoolein transacylation" EXACT [] +synonym: "monooleoylglycerol O-acyltransferase activity" EXACT [] +synonym: "monooleoylglycerol transacylase activity" EXACT [] +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0051265 +name: diolein transacylation activity +namespace: molecular_function +def: "Catalysis of the reaction: diolein (dioleoylglycerol) + mono-olein (mono-oleoylglycerol) = triolein (trioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid; triolein or trioleoylglycerol is also known as olein." [GOC:ai, PMID:15364929] +synonym: "acyl-CoA-independent diolein transacylation" EXACT [] +synonym: "dioleoylglycerol O-acyltransferase activity" EXACT [] +synonym: "dioleoylglycerol transacylase activity" EXACT [] +synonym: "DOG transacylation" EXACT [] +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0051266 +name: sirohydrochlorin ferrochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sirohydrochlorin + Fe2+ = siroheme + 2 H+." [EC:4.99.1.4, MetaCyc:SIROHEME-FERROCHELAT-RXN] +subset: gosubset_prok +synonym: "CysG" RELATED [EC:4.99.1.4] +synonym: "Met8P" RELATED [EC:4.99.1.4] +synonym: "SirB" RELATED [EC:4.99.1.4] +synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.4] +synonym: "siroheme synthase activity" BROAD [] +synonym: "sirohydrochlorin ferro-lyase activity" EXACT [] +xref: EC:4.99.1.4 +xref: MetaCyc:SIROHEME-FERROCHELAT-RXN +is_a: GO:0004325 ! ferrochelatase activity + +[Term] +id: GO:0051267 +name: CP2 mannose-ethanolamine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine phosphate (EtN-P) + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134] +synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT [] +synonym: "CP2 ethanolamine phosphate transferase activity" EXACT [] +synonym: "CP2 EtN-P transferase activity" EXACT [] +synonym: "CP2 phosphoethanolamine transferase activity" EXACT [] +synonym: "gpi7 activity" RELATED [] +is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity + +[Term] +id: GO:0051268 +name: alpha-keto amide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669] +xref: EC:1.2.-.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0051269 +name: alpha-keto ester reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669] +xref: EC:1.2.-.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0051270 +name: regulation of cell motion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the movement of a cell." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of cell movement" EXACT [] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0006928 ! cell motion + +[Term] +id: GO:0051271 +name: negative regulation of cell motion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a cell." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of cell motility" EXACT [] +synonym: "down-regulation of cell motility" EXACT [] +synonym: "downregulation of cell motility" EXACT [] +synonym: "inhibition of cell motility" NARROW [] +synonym: "negative regulation of cell movement" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051270 ! regulation of cell motion +relationship: negatively_regulates GO:0006928 ! cell motion + +[Term] +id: GO:0051272 +name: positive regulation of cell motion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the movement of a cell." [GOC:ai] +subset: gosubset_prok +synonym: "activation of cell motility" NARROW [] +synonym: "positive regulation of cell movement" EXACT [] +synonym: "stimulation of cell motility" NARROW [] +synonym: "up regulation of cell motility" EXACT [] +synonym: "up-regulation of cell motility" EXACT [] +synonym: "upregulation of cell motility" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051270 ! regulation of cell motion +relationship: positively_regulates GO:0006928 ! cell motion + +[Term] +id: GO:0051273 +name: beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai] +subset: gosubset_prok +synonym: "beta-glucan metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process + +[Term] +id: GO:0051274 +name: beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai] +subset: gosubset_prok +synonym: "beta-glucan anabolism" EXACT [] +synonym: "beta-glucan biosynthesis" EXACT [] +synonym: "beta-glucan formation" EXACT [] +synonym: "beta-glucan synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0051275 +name: beta-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai] +subset: gosubset_prok +synonym: "beta-glucan breakdown" EXACT [] +synonym: "beta-glucan catabolism" EXACT [] +synonym: "beta-glucan degradation" EXACT [] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0051276 +name: chromosome organization +namespace: biological_process +alt_id: GO:0007001 +alt_id: GO:0051277 +def: "A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "chromosome organisation and biogenesis (sensu Bacteria)" EXACT [] +synonym: "chromosome organisation and biogenesis (sensu Eukaryota)" EXACT [] +synonym: "chromosome organization and biogenesis" EXACT [] +synonym: "chromosome organization and biogenesis (sensu Bacteria)" EXACT [] +synonym: "chromosome organization and biogenesis (sensu Eukaryota)" EXACT [] +synonym: "maintenance of genome integrity" RELATED [] +synonym: "nuclear genome maintenance" RELATED [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0051278 +name: fungal-type cell wall polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu] +synonym: "cell wall polysaccharide anabolism (sensu Fungi)" EXACT [] +synonym: "cell wall polysaccharide formation (sensu Fungi)" EXACT [] +synonym: "cell wall polysaccharide synthesis (sensu Fungi)" EXACT [] +synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0051279 +name: regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb] +synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT [] +synonym: "regulation of calcium mobilization" EXACT [] +synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT [] +synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051280 +name: negative regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] +synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD [] +synonym: "negative regulation of calcium mobilization" BROAD [] +synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051281 +name: positive regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] +synonym: "activation of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD [] +synonym: "positive regulation of calcium mobilization" BROAD [] +synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT [] +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051282 +name: regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051283 +name: negative regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "down regulation of sequestering of calcium ion" EXACT [] +synonym: "down-regulation of sequestering of calcium ion" EXACT [] +synonym: "downregulation of sequestering of calcium ion" EXACT [] +synonym: "inhibition of sequestering of calcium ion" NARROW [] +synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051282 ! regulation of sequestering of calcium ion +relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051284 +name: positive regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "activation of sequestering of calcium ion" NARROW [] +synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT [] +synonym: "stimulation of sequestering of calcium ion" NARROW [] +synonym: "up regulation of sequestering of calcium ion" EXACT [] +synonym: "up-regulation of sequestering of calcium ion" EXACT [] +synonym: "upregulation of sequestering of calcium ion" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051282 ! regulation of sequestering of calcium ion +relationship: positively_regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051285 +name: cell cortex of cell tip +namespace: cellular_component +def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai] +synonym: "cell cortex of cell end" EXACT [] +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0051286 ! cell tip + +[Term] +id: GO:0051286 +name: cell tip +namespace: cellular_component +def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth may occur." [GOC:ai, GOC:vw] +synonym: "cell end" EXACT [] +is_a: GO:0030427 ! site of polarized growth + +[Term] +id: GO:0051287 +name: NAD binding +namespace: molecular_function +alt_id: GO:0051288 +def: "Interacting selectively with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai] +synonym: "NAD (oxidized) binding" EXACT [] +synonym: "NAD (reduced) binding" EXACT [] +synonym: "NADH binding" EXACT [] +synonym: "nicotinamide adenine dinucleotide binding" EXACT [] +synonym: "oxidized NAD binding" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [] +synonym: "reduced NAD binding" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [] +is_a: GO:0050662 ! coenzyme binding + +[Term] +id: GO:0051289 +name: protein homotetramerization +namespace: biological_process +def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators] +subset: gosubset_prok +synonym: "protein homotetramer assembly" EXACT [] +synonym: "protein homotetramer biosynthesis" EXACT [] +synonym: "protein homotetramer biosynthetic process" EXACT [] +synonym: "protein homotetramer formation" EXACT [] +is_a: GO:0051260 ! protein homooligomerization +is_a: GO:0051262 ! protein tetramerization + +[Term] +id: GO:0051290 +name: protein heterotetramerization +namespace: biological_process +def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated nonidentical subunits." [GOC:go_curators] +subset: gosubset_prok +synonym: "protein heterotetramer assembly" EXACT [] +synonym: "protein heterotetramer biosynthesis" EXACT [] +synonym: "protein heterotetramer biosynthetic process" EXACT [] +synonym: "protein heterotetramer formation" EXACT [] +is_a: GO:0051262 ! protein tetramerization +is_a: GO:0051291 ! protein heterooligomerization + +[Term] +id: GO:0051291 +name: protein heterooligomerization +namespace: biological_process +def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of nonidentical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] +subset: gosubset_prok +synonym: "protein heterooligomer assembly" EXACT [] +synonym: "protein heterooligomer biosynthesis" EXACT [] +synonym: "protein heterooligomer biosynthetic process" EXACT [] +synonym: "protein heterooligomer formation" EXACT [] +is_a: GO:0051259 ! protein oligomerization + +[Term] +id: GO:0051292 +name: nuclear pore complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah] +synonym: "NPC assembly" EXACT [] +synonym: "nuclear pore assembly" EXACT [] +synonym: "nuclear pore biogenesis" EXACT [] +synonym: "nuclear pore biosynthesis" EXACT [] +synonym: "nuclear pore complex biogenesis" EXACT [] +synonym: "nuclear pore complex biosynthesis" EXACT [] +synonym: "nuclear pore complex formation" EXACT [] +synonym: "nuclear pore formation" EXACT [] +is_a: GO:0006999 ! nuclear pore organization +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0051293 +name: establishment of spindle localization +namespace: biological_process +def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai] +synonym: "spindle positioning" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051653 ! spindle localization + +[Term] +id: GO:0051294 +name: establishment of spindle orientation +namespace: biological_process +def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] +synonym: "orienting of spindle" EXACT [] +synonym: "spindle orientation" EXACT [] +is_a: GO:0051293 ! establishment of spindle localization + +[Term] +id: GO:0051295 +name: establishment of meiotic spindle localization +namespace: biological_process +def: "The cell cycle process whereby the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai] +synonym: "meiotic spindle positioning" EXACT [] +synonym: "spindle positioning during meiosis" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051293 ! establishment of spindle localization +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051296 +name: establishment of meiotic spindle orientation +namespace: biological_process +def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai] +synonym: "establishment of spindle orientation during meiosis" EXACT [] +synonym: "meiotic spindle orientation" EXACT [] +synonym: "orienting of meiotic spindle" EXACT [] +is_a: GO:0051294 ! establishment of spindle orientation +is_a: GO:0051295 ! establishment of meiotic spindle localization + +[Term] +id: GO:0051297 +name: centrosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "centrosome organisation and biogenesis" EXACT [] +synonym: "centrosome organization and biogenesis" EXACT [] +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0051298 +name: centrosome duplication +namespace: biological_process +def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] +synonym: "centrosome replication" EXACT [] +is_a: GO:0051297 ! centrosome organization +relationship: part_of GO:0007098 ! centrosome cycle + +[Term] +id: GO:0051299 +name: centrosome separation +namespace: biological_process +def: "The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] +is_a: GO:0051297 ! centrosome organization +relationship: part_of GO:0007098 ! centrosome cycle + +[Term] +id: GO:0051300 +name: spindle pole body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "SPB organization and biogenesis" EXACT [] +synonym: "spindle pole body organisation and biogenesis" EXACT [] +synonym: "spindle pole body organization and biogenesis" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0051301 +name: cell division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0051302 +name: regulation of cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051301 ! cell division + +[Term] +id: GO:0051303 +name: establishment of chromosome localization +namespace: biological_process +def: "The directed movement of a chromosome to a specific location." [GOC:ai] +synonym: "chromosome positioning" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0050000 ! chromosome localization + +[Term] +id: GO:0051304 +name: chromosome separation +namespace: biological_process +def: "The cell cycle process whereby paired chromosomes are detached from each other. In budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051305 +name: chromosome movement towards spindle pole +namespace: biological_process +def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai] +synonym: "chromosome migration to spindle pole" EXACT [] +synonym: "chromosome movement" BROAD [] +synonym: "chromosome movement to spindle pole" EXACT [] +is_a: GO:0051303 ! establishment of chromosome localization +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051306 +name: mitotic sister chromatid separation +namespace: biological_process +def: "The process by which sister chromatids are physically detached from each other during mitosis." [GOC:ai] +synonym: "chromosome separation during mitosis" RELATED [] +synonym: "mitotic chromosome separation" RELATED [] +synonym: "sister chromatid separation during mitosis" EXACT [] +is_a: GO:0051304 ! chromosome separation +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0051307 +name: meiotic chromosome separation +namespace: biological_process +def: "The process by which chromosomes are physically detached from each other during meiosis." [GOC:ai] +synonym: "chromosome separation during meiosis" EXACT [] +is_a: GO:0051304 ! chromosome separation +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051308 +name: male meiosis chromosome separation +namespace: biological_process +def: "The process by which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai] +synonym: "chromosome separation during male meiosis" EXACT [] +is_a: GO:0007060 ! male meiosis chromosome segregation +is_a: GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0051309 +name: female meiosis chromosome separation +namespace: biological_process +def: "The process by which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai] +synonym: "chromosome separation during female meiosis" EXACT [] +is_a: GO:0016321 ! female meiosis chromosome segregation +is_a: GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0051310 +name: metaphase plate congression +namespace: biological_process +def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai] +is_a: GO:0051303 ! establishment of chromosome localization +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051311 +name: meiotic metaphase plate congression +namespace: biological_process +def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai] +synonym: "metaphase plate congression during meiosis" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051310 ! metaphase plate congression +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051312 +name: chromosome decondensation +namespace: biological_process +def: "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0051313 +name: attachment of spindle microtubules to chromosome +namespace: biological_process +def: "The process by which spindle microtubules become physically associated with a chromosome." [GOC:ai] +synonym: "microtubule and chromosome interaction" BROAD [] +synonym: "spindle chromosome attachment" EXACT [] +synonym: "spindle-chromosome interaction" BROAD [] +is_a: GO:0007017 ! microtubule-based process +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051314 +name: attachment of spindle microtubules to mitotic chromosome +namespace: biological_process +def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during mitosis." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051313 ! attachment of spindle microtubules to chromosome +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0051315 +name: attachment of spindle microtubules to kinetochore during mitosis +namespace: biological_process +def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt] +is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0051316 +name: attachment of spindle microtubules to kinetochore during meiotic chromosome segregation +namespace: biological_process +def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiotic chromosome segregation." [GOC:ai] +synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED [] +is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051317 +name: attachment of spindle microtubules to meiotic chromosome +namespace: biological_process +def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during meiosis." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051313 ! attachment of spindle microtubules to chromosome +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051318 +name: G1 phase +namespace: biological_process +def: "Progression through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:ai] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051319 +name: G2 phase +namespace: biological_process +def: "Progression through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:ai] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051320 +name: S phase +namespace: biological_process +def: "Progression through S phase, the part of the cell cycle during which DNA synthesis takes place." [GOC:ai] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051321 +name: meiotic cell cycle +namespace: biological_process +def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai] +is_a: GO:0007049 ! cell cycle + +[Term] +id: GO:0051322 +name: anaphase +namespace: biological_process +def: "Progression through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [http://www.onelook.com] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051323 +name: metaphase +namespace: biological_process +def: "Progression through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell." [http://www.onelook.com] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051324 +name: prophase +namespace: biological_process +def: "Progression through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:ai] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051325 +name: interphase +namespace: biological_process +def: "Progression through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [http://www.onelook.com] +synonym: "karyostasis" EXACT [] +synonym: "resting phase" BROAD [] +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0051326 +name: telophase +namespace: biological_process +def: "Progression through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [http://www.onelook.com] +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051327 +name: M phase of meiotic cell cycle +namespace: biological_process +def: "Progression through M phase, the part of the meiotic cell cycle during which meiosis takes place." [GOC:ai] +is_a: GO:0000279 ! M phase +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051328 +name: interphase of meiotic cell cycle +namespace: biological_process +def: "Progression through interphase, the stage of cell cycle between successive rounds of meiosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai] +is_a: GO:0051325 ! interphase +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051329 +name: interphase of mitotic cell cycle +namespace: biological_process +def: "Progression through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai] +is_a: GO:0051325 ! interphase +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0051330 +name: G1 phase of meiotic cell cycle +namespace: biological_process +def: "Progression through G1 phase, one of two 'gap' phases in the meiotic cell cycle; G1 is the interval between the completion of meiosis and the beginning of DNA synthesis." [GOC:ai] +is_a: GO:0051318 ! G1 phase +relationship: part_of GO:0051328 ! interphase of meiotic cell cycle + +[Term] +id: GO:0051331 +name: G2 phase of meiotic cell cycle +namespace: biological_process +def: "Progression through G2 phase, one of two 'gap' phases in the meiotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of meiosis." [GOC:ai] +is_a: GO:0051319 ! G2 phase +relationship: part_of GO:0051328 ! interphase of meiotic cell cycle + +[Term] +id: GO:0051332 +name: S phase of meiotic cell cycle +namespace: biological_process +def: "Progression through S phase, the part of the meiotic cell cycle during which DNA synthesis takes place." [GOC:ai] +is_a: GO:0051320 ! S phase +relationship: part_of GO:0051328 ! interphase of meiotic cell cycle + +[Term] +id: GO:0051333 +name: meiotic nuclear envelope reassembly +namespace: biological_process +def: "The cell cycle process whereby the reformation of the nuclear envelope during meiosis occurs." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031468 ! nuclear envelope reassembly +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051334 +name: meiosis I nuclear envelope reassembly +namespace: biological_process +def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai] +is_a: GO:0051333 ! meiotic nuclear envelope reassembly +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0051335 +name: meiosis II nuclear envelope reassembly +namespace: biological_process +def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai] +is_a: GO:0051333 ! meiotic nuclear envelope reassembly +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0051336 +name: regulation of hydrolase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai] +subset: gosubset_prok +synonym: "hydrolase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051337 +name: amitosis +namespace: biological_process +def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "direct nuclear division" EXACT [] +synonym: "Remak nuclear division" EXACT [] +is_a: GO:0000280 ! nuclear division + +[Term] +id: GO:0051338 +name: regulation of transferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai] +subset: gosubset_prok +synonym: "transferase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051339 +name: regulation of lyase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, GOC:ai] +subset: gosubset_prok +synonym: "lyase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051340 +name: regulation of ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai] +subset: gosubset_prok +synonym: "ligase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051341 +name: regulation of oxidoreductase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai] +subset: gosubset_prok +synonym: "oxidoreductase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051342 +name: regulation of cyclic-nucleotide phosphodiesterase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb] +synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT [] +synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW [] +synonym: "cAMP phosphodiesterase regulator" NARROW [] +synonym: "phosphodiesterase regulator" RELATED [] +synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] +synonym: "regulation of cAMP phosphodiesterase activity" NARROW [] +synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051343 +name: positive regulation of cyclic-nucleotide phosphodiesterase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] +synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT [] +synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW [] +synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW [] +synonym: "cAMP phosphodiesterase activator" NARROW [] +synonym: "phosphodiesterase activator" RELATED [] +synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] +synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW [] +synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] +synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW [] +synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0051344 +name: negative regulation of cyclic-nucleotide phosphodiesterase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] +synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT [] +synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW [] +synonym: "cAMP phosphodiesterase inhibitor" NARROW [] +synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW [] +synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] +synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW [] +synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] +synonym: "phosphodiesterase inhibitor" RELATED [] +is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0051345 +name: positive regulation of hydrolase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] +subset: gosubset_prok +synonym: "activation of hydrolase activity" NARROW [] +synonym: "hydrolase activator" EXACT [] +synonym: "stimulation of hydrolase activity" NARROW [] +synonym: "up regulation of hydrolase activity" EXACT [] +synonym: "up-regulation of hydrolase activity" EXACT [] +synonym: "upregulation of hydrolase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051346 +name: negative regulation of hydrolase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of hydrolase activity" EXACT [] +synonym: "down-regulation of hydrolase activity" EXACT [] +synonym: "downregulation of hydrolase activity" EXACT [] +synonym: "hydrolase inhibitor" EXACT [] +synonym: "inhibition of hydrolase activity" NARROW [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051347 +name: positive regulation of transferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] +subset: gosubset_prok +synonym: "activation of transferase activity" NARROW [] +synonym: "stimulation of transferase activity" NARROW [] +synonym: "transferase activator" EXACT [] +synonym: "up regulation of transferase activity" EXACT [] +synonym: "up-regulation of transferase activity" EXACT [] +synonym: "upregulation of transferase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0051348 +name: negative regulation of transferase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of transferase activity" EXACT [] +synonym: "down-regulation of transferase activity" EXACT [] +synonym: "downregulation of transferase activity" EXACT [] +synonym: "inhibition of transferase activity" NARROW [] +synonym: "transferase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0051349 +name: positive regulation of lyase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] +synonym: "activation of lyase activity" NARROW [] +synonym: "lyase activator" EXACT [] +synonym: "stimulation of lyase activity" NARROW [] +synonym: "up regulation of lyase activity" EXACT [] +synonym: "up-regulation of lyase activity" EXACT [] +synonym: "upregulation of lyase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0051350 +name: negative regulation of lyase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] +synonym: "down regulation of lyase activity" EXACT [] +synonym: "down-regulation of lyase activity" EXACT [] +synonym: "downregulation of lyase activity" EXACT [] +synonym: "inhibition of lyase activity" NARROW [] +synonym: "lyase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0051351 +name: positive regulation of ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "activation of ligase activity" NARROW [] +synonym: "ligase activator" EXACT [] +synonym: "stimulation of ligase activity" NARROW [] +synonym: "up regulation of ligase activity" EXACT [] +synonym: "up-regulation of ligase activity" EXACT [] +synonym: "upregulation of ligase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0051352 +name: negative regulation of ligase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of ligase activity" EXACT [] +synonym: "down-regulation of ligase activity" EXACT [] +synonym: "downregulation of ligase activity" EXACT [] +synonym: "inhibition of ligase activity" NARROW [] +synonym: "ligase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0051353 +name: positive regulation of oxidoreductase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] +subset: gosubset_prok +synonym: "activation of oxidoreductase activity" NARROW [] +synonym: "oxidoreductase activator" EXACT [] +synonym: "stimulation of oxidoreductase activity" NARROW [] +synonym: "up regulation of oxidoreductase activity" EXACT [] +synonym: "up-regulation of oxidoreductase activity" EXACT [] +synonym: "upregulation of oxidoreductase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0051354 +name: negative regulation of oxidoreductase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of oxidoreductase activity" EXACT [] +synonym: "down-regulation of oxidoreductase activity" EXACT [] +synonym: "downregulation of oxidoreductase activity" EXACT [] +synonym: "inhibition of oxidoreductase activity" NARROW [] +synonym: "oxidoreductase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0051355 +name: proprioception during equilibrioception +namespace: biological_process +def: "The series of events during equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] +synonym: "equilibrioception by proprioception" EXACT [] +synonym: "perception of orientation with respect to gravity by proprioception" EXACT [] +is_a: GO:0019230 ! proprioception +relationship: part_of GO:0050957 ! equilibrioception + +[Term] +id: GO:0051356 +name: visual perception during equilibrioception +namespace: biological_process +def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] +synonym: "equilibrioception by visual perception" NARROW [] +synonym: "perception of orientation with respect to gravity by visual perception" EXACT [] +is_a: GO:0007601 ! visual perception +relationship: part_of GO:0050957 ! equilibrioception + +[Term] +id: GO:0051357 +name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one +namespace: biological_process +def: "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377] +comment: Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'. +synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] +xref: RESID:AA0377 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051358 +name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine +namespace: biological_process +def: "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0378 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051359 +name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine +namespace: biological_process +def: "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0379 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051360 +name: peptide cross-linking via L-asparagine 5-imidazolinone glycine +namespace: biological_process +def: "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0380 +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051361 +name: peptide cross-linking via L-lysine 5-imidazolinone glycine +namespace: biological_process +def: "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0381 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051362 +name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] +xref: RESID:AA0382 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051363 +name: peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein +namespace: biological_process +def: "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383] +comment: Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus. +subset: gosubset_prok +xref: RESID:AA0383 +is_a: GO:0018104 ! peptidoglycan-protein cross-linking +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0051364 +name: N-terminal peptidyl-proline N-formylation +namespace: biological_process +def: "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384] +xref: RESID:AA0384 +is_a: GO:0018004 ! N-terminal protein formylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0051365 +name: cellular response to potassium ion starvation +namespace: biological_process +def: "A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm] +synonym: "cellular response to K+ ion deprivation" EXACT [] +synonym: "cellular response to K+ ion starvation" EXACT [] +synonym: "cellular response to potassium ion deprivation" EXACT [] +synonym: "cellular response to potassium starvation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0051366 +name: protein amino acid decanoylation +namespace: biological_process +def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg] +is_a: GO:0006497 ! protein amino acid lipidation +is_a: GO:0043543 ! protein amino acid acylation + +[Term] +id: GO:0051367 +name: peptidyl-serine decanoylation +namespace: biological_process +def: "The posttranslational decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385] +xref: RESID:AA0385 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0051366 ! protein amino acid decanoylation + +[Term] +id: GO:0051368 +name: peptidyl-threonine octanoylation +namespace: biological_process +def: "The posttranslational octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] +xref: RESID:AA0386 +is_a: GO:0018190 ! protein amino acid octanoylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0051369 +name: peptidyl-threonine decanoylation +namespace: biological_process +def: "The posttranslational decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] +xref: RESID:AA0387 +is_a: GO:0018210 ! peptidyl-threonine modification +is_a: GO:0051366 ! protein amino acid decanoylation + +[Term] +id: GO:0051370 +name: ZASP binding +namespace: molecular_function +def: "Interacting selectively with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871] +synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051371 +name: muscle alpha-actinin binding +namespace: molecular_function +def: "Interacting selectively with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] +synonym: "alpha-actinin 2 binding" NARROW [] +synonym: "alpha-actinin 3 binding" NARROW [] +is_a: GO:0051393 ! alpha-actinin binding + +[Term] +id: GO:0051372 +name: nonmuscle alpha-actinin binding +namespace: molecular_function +def: "Interacting selectively with nonmuscle isoforms of actinin. Nonmuscle alpha-actinin is found at the leading edge of motile cells, cell adhesion sites, focal contacts and along actin stress fibers in migrating cells." [PMID:15014165] +synonym: "alpha-actinin 1 binding" NARROW [] +synonym: "alpha-actinin 4 binding" EXACT [] +is_a: GO:0051393 ! alpha-actinin binding + +[Term] +id: GO:0051373 +name: FATZ binding +namespace: molecular_function +def: "Interacting selectively with a family of FATZ proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] +synonym: "calsarcin binding" EXACT [] +synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051374 +name: FATZ 1 binding +namespace: molecular_function +def: "Interacting selectively with FATZ 1, a protein of FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871] +synonym: "calsarcin 2 binding" EXACT [] +is_a: GO:0051373 ! FATZ binding + +[Term] +id: GO:0051375 +name: FATZ 2 binding +namespace: molecular_function +def: "Interacting selectively with FATZ 2, a protein of the FATZ family that is highly expressed in skeletal muscle fiber fast IIa and slow I and in cardiac muscle." [PMID:10984498, PMID:11699871] +synonym: "calsarcin 1 binding" EXACT [] +is_a: GO:0051373 ! FATZ binding + +[Term] +id: GO:0051376 +name: FATZ 3 binding +namespace: molecular_function +def: "Interacting selectively with FATZ 3, a protein of the FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871] +synonym: "calsarcin 3 binding" EXACT [] +is_a: GO:0051373 ! FATZ binding + +[Term] +id: GO:0051377 +name: mannose-ethanolamine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136] +synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT [] +synonym: "ethanolamine phosphate transferase activity" BROAD [] +synonym: "EtN-P transferase activity" EXACT [] +synonym: "phosphoethanolamine transferase activity" BROAD [] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0051378 +name: serotonin binding +namespace: molecular_function +def: "Interacting selectively with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] +synonym: "5-hydroxytryptamine binding" EXACT [] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0051379 +name: epinephrine binding +namespace: molecular_function +def: "Interacting selectively with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] +synonym: "adrenaline binding" EXACT [] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0051380 +name: norepinephrine binding +namespace: molecular_function +def: "Interacting selectively with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] +synonym: "noradrenaline binding" EXACT [] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0051381 +name: histamine binding +namespace: molecular_function +def: "Interacting selectively with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0051382 +name: kinetochore assembly +namespace: biological_process +alt_id: GO:0000069 +def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai] +synonym: "centromere and kinetochore complex maturation" NARROW [] +synonym: "centromere/kinetochore complex maturation" NARROW [] +synonym: "kinetochore biogenesis" EXACT [] +synonym: "kinetochore biosynthesis" EXACT [] +synonym: "kinetochore formation" EXACT [] +is_a: GO:0043623 ! cellular protein complex assembly +is_a: GO:0051383 ! kinetochore organization +relationship: part_of GO:0034508 ! centromere complex assembly + +[Term] +id: GO:0051383 +name: kinetochore organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "kinetochore organisation and biogenesis" EXACT [] +synonym: "kinetochore organization and biogenesis" EXACT [] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0051384 +name: response to glucocorticoid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123] +is_a: GO:0031960 ! response to corticosteroid stimulus + +[Term] +id: GO:0051385 +name: response to mineralocorticoid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123] +is_a: GO:0031960 ! response to corticosteroid stimulus + +[Term] +id: GO:0051386 +name: regulation of nerve growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai] +synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT [] +synonym: "regulation of NGF receptor signaling pathway" EXACT [] +synonym: "regulation of NGF receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048011 ! nerve growth factor receptor signaling pathway + +[Term] +id: GO:0051387 +name: negative regulation of nerve growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai] +synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT [] +synonym: "negative regulation of NGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of NGF receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048011 ! nerve growth factor receptor signaling pathway + +[Term] +id: GO:0051388 +name: positive regulation of nerve growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai] +synonym: "activation of nerve growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT [] +synonym: "positive regulation of NGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of NGF receptor signalling pathway" EXACT [] +synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway +relationship: positively_regulates GO:0048011 ! nerve growth factor receptor signaling pathway + +[Term] +id: GO:0051389 +name: inactivation of MAPKK activity +namespace: biological_process +def: "Any process that terminates the activity of the active enzyme MAP kinase kinase." [GOC:ai] +synonym: "inactivation of MAP kinase kinase activity" EXACT [] +synonym: "termination of MAP kinase kinase activity" EXACT [] +synonym: "termination of MAPKK activity" EXACT [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0051390 +name: inactivation of MAPKKK activity +namespace: biological_process +def: "Any process that terminates the activity of the active enzyme MAP kinase kinase kinase." [GOC:ai] +synonym: "inactivation of MAP kinase kinase kinase activity" EXACT [] +synonym: "termination of MAP kinase kinase kinase activity" EXACT [] +synonym: "termination of MAPKKK activity" EXACT [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +relationship: part_of GO:0000165 ! MAPKKK cascade + +[Term] +id: GO:0051391 +name: tRNA acetylation +namespace: biological_process +def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0051392 +name: tRNA N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780] +synonym: "tRNA cytidine N-acetyltransferase activity" EXACT [] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0051393 +name: alpha-actinin binding +namespace: molecular_function +def: "Interacting selectively with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] +is_a: GO:0042805 ! actinin binding + +[Term] +id: GO:0051394 +name: regulation of nerve growth factor receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai] +synonym: "regulation of NGF receptor activity" EXACT [] +is_a: GO:0010469 ! regulation of receptor activity +is_a: GO:0043393 ! regulation of protein binding +is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway + +[Term] +id: GO:0051395 +name: negative regulation of nerve growth factor receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai] +synonym: "down regulation of nerve growth factor receptor activity" EXACT [] +synonym: "down-regulation of nerve growth factor receptor activity" EXACT [] +synonym: "downregulation of nerve growth factor receptor activity" EXACT [] +synonym: "inhibition of nerve growth factor receptor activity" NARROW [] +synonym: "negative regulation of NGF receptor activity" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:0051394 ! regulation of nerve growth factor receptor activity + +[Term] +id: GO:0051396 +name: positive regulation of nerve growth factor receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai] +synonym: "activation of nerve growth factor receptor activity" NARROW [] +synonym: "positive regulation of NGF receptor activity" EXACT [] +synonym: "stimulation of nerve growth factor receptor activity" NARROW [] +synonym: "up regulation of nerve growth factor receptor activity" EXACT [] +synonym: "up-regulation of nerve growth factor receptor activity" EXACT [] +synonym: "upregulation of nerve growth factor receptor activity" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:0051394 ! regulation of nerve growth factor receptor activity + +[Term] +id: GO:0051397 +name: N-terminal basic amino acid aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0051398 +name: N-terminal lysine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] +comment: This term was made obsolete because it represents a gene product. +synonym: "lysine aminopeptidase activity" BROAD [] +synonym: "lysyl aminopeptidase activity" BROAD [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0051399 +name: N-terminal arginine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] +comment: This term was made obsolete because it represents a gene product. +synonym: "arginine aminopeptidase activity" BROAD [] +synonym: "argininyl aminopeptidase activity" BROAD [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0051400 +name: BH domain binding +namespace: molecular_function +def: "Interacting selectively with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] +synonym: "Bcl-2 homology domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0051401 +name: CH domain binding +namespace: molecular_function +def: "Interacting selectively with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021] +synonym: "calponin homology domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0051402 +name: neuron apoptosis +namespace: biological_process +def: "The process of apoptosis in neurons, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MeSH:A.08.663] +synonym: "apoptosis of neuronal cells" EXACT [] +synonym: "apoptosis of neurons" EXACT [] +synonym: "neuron programmed cell death by apoptosis" EXACT [] +synonym: "neuronal cell apoptosis" EXACT [] +synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] +synonym: "programmed cell death of neurons by apoptosis" EXACT [] +synonym: "programmed cell death, neuronal cells" EXACT [] +synonym: "programmed cell death, neurons" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0051403 +name: stress-activated MAPK cascade +namespace: biological_process +def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] +synonym: "p38 MAPK signaling" EXACT [] +synonym: "p38 MAPK signalling" EXACT [] +synonym: "stress-activated MAPK signaling pathway" EXACT [] +synonym: "stress-activated MAPK signalling pathway" EXACT [] +synonym: "stress-activated MAPKKK cascade" EXACT [] +synonym: "stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "stress-activated MAPKKK signalling pathway" EXACT [] +is_a: GO:0000165 ! MAPKKK cascade +is_a: GO:0031098 ! stress-activated protein kinase signaling pathway + +[Term] +id: GO:0051404 +name: clostripain activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8] +synonym: "clostridiopeptidase B activity" EXACT [] +synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8] +xref: EC:3.4.22.8 +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0051405 +name: microbial collagenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3] +synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3] +synonym: "azocollase activity" EXACT [EC:3.4.24.3] +synonym: "clostridiopeptidase A activity" EXACT [] +synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3] +synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3] +synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3] +synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3] +synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3] +synonym: "collagen protease activity" EXACT [EC:3.4.24.3] +synonym: "collagenase 1 activity" EXACT [] +synonym: "collagenase A activity" EXACT [] +synonym: "collagenase I activity" EXACT [EC:3.4.24.3] +synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3] +synonym: "kollaza" RELATED [EC:3.4.24.3] +synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3] +synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3] +synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3] +synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3] +synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3] +synonym: "nucleolysin" RELATED [EC:3.4.24.3] +synonym: "soycollagestin" RELATED [EC:3.4.24.3] +xref: EC:3.4.24.3 +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0051406 +name: beta-actinin binding +namespace: molecular_function +def: "Interacting selectively with beta-actinin, a heterodimeric actin-binding protein which caps the barbed end of actin filaments and nucleates actin polymerization in a calcium-independent manner. In myofibrils it is localized in the Z-lines." [PMID:11699871, PMID:2341404, PMID:9742448] +synonym: "capZ binding" EXACT [] +is_a: GO:0042805 ! actinin binding + +[Term] +id: GO:0051407 +name: glycerone phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai] +synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT [] +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0051408 +name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai] +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0051409 +name: response to nitrosative stress +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0051410 +name: detoxification of nitrogen compound +namespace: biological_process +def: "Any process that reduce or remove the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] +synonym: "detoxification of nitrogenous compound" EXACT [] +synonym: "nitric oxide (NO) detoxification" NARROW [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0009636 ! response to toxin +is_a: GO:0051409 ! response to nitrosative stress + +[Term] +id: GO:0051411 +name: ALP binding +namespace: molecular_function +def: "Interacting selectively wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871] +synonym: "actinin-associated LIM protein binding" EXACT [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051412 +name: response to corticosterone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347] +is_a: GO:0051384 ! response to glucocorticoid stimulus +is_a: GO:0051385 ! response to mineralocorticoid stimulus + +[Term] +id: GO:0051413 +name: response to cortisone stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11276391] +is_a: GO:0051384 ! response to glucocorticoid stimulus + +[Term] +id: GO:0051414 +name: response to cortisol stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11276391] +synonym: "response to hydrocortisone stimulus" EXACT [] +is_a: GO:0051384 ! response to glucocorticoid stimulus + +[Term] +id: GO:0051415 +name: interphase microtubule nucleation by interphase microtubule organizing center +namespace: biological_process +def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai] +synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT [] +synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT [] +synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT [] +synonym: "microtubule nucleation during interphase by IMTOC" EXACT [] +synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT [] +is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051416 +name: myotilin binding +namespace: molecular_function +def: "Interacting selectively with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051417 +name: microtubule nucleation by spindle pole body +namespace: biological_process +def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai] +synonym: "microtubule nucleation by SPB" EXACT [] +synonym: "SPB-mediated microtubule nucleation" EXACT [] +synonym: "spindle pole body-mediated microtubule nucleation" EXACT [] +is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center + +[Term] +id: GO:0051418 +name: microtubule nucleation by microtubule organizing center +namespace: biological_process +def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai] +synonym: "microtubule nucleation by microtubule organising centre" EXACT [] +synonym: "microtubule nucleation by MTOC" EXACT [] +synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT [] +synonym: "MTOC-mediated microtubule nucleation" EXACT [] +is_a: GO:0007020 ! microtubule nucleation + +[Term] +id: GO:0051419 +name: nebulin binding +namespace: molecular_function +def: "Interacting selectively with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051420 +name: nebulette binding +namespace: molecular_function +def: "Interacting selectively with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051421 +name: regulation of endo-1,4-beta-xylanase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] +synonym: "endo-1,4-beta-xylanase regulator" RELATED [] +synonym: "xylanase regulator" RELATED [] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051422 +name: negative regulation of endo-1,4-beta-xylanase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] +synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "endo-1,4-beta-xylanase inhibitor" RELATED [] +synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW [] +synonym: "xylanase inhibitor" RELATED [] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity + +[Term] +id: GO:0051423 +name: positive regulation of endo-1,4-beta-xylanase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] +synonym: "activation of endo-1,4-beta-xylanase activity" NARROW [] +synonym: "endo-1,4-beta-xylanase activator" RELATED [] +synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW [] +synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "xylanase activator" RELATED [] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity + +[Term] +id: GO:0051424 +name: corticotropin-releasing hormone binding +namespace: molecular_function +def: "Interacting selectively with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [http://www.onelook.com] +synonym: "corticoliberin binding" EXACT [] +synonym: "corticotropin-releasing factor binding" EXACT [] +synonym: "CRH binding" EXACT [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0051425 +name: PTB domain binding +namespace: molecular_function +def: "Interacting selectively with a phosphotyrosine-binding (PTB) domain of a protein." [Pfam:PF02174.5, PMID:15924411] +synonym: "phosphotyrosine-interacting domain binding" EXACT [] +synonym: "PID binding" BROAD [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0051426 +name: spindle pole body maturation +namespace: biological_process +def: "Any process by which the newly duplicated spindle pole body (SPB) is processed to attain its full functional capacity. In S. pombe, early maturation includes increase in size of the lamellar bodies, invagination of the nuclear envelope, and accumulation of material in a pocket under the SPB. Late maturation includes fenestration of the nuclear envelope, SPB separation and entry into the nucleus, giving rise to the spindle." [GOC:ai, PMID:15132994, PMID:15385623] +synonym: "SPB maturation" EXACT [] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051300 ! spindle pole body organization + +[Term] +id: GO:0051427 +name: hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a receptor for hormones." [GOC:ai] +is_a: GO:0005102 ! receptor binding + +[Term] +id: GO:0051428 +name: peptide hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a receptor for peptide hormones." [GOC:ai] +synonym: "polypeptide hormone receptor binding" EXACT [] +is_a: GO:0051427 ! hormone receptor binding + +[Term] +id: GO:0051429 +name: corticotropin-releasing hormone receptor binding +namespace: molecular_function +def: "Interacting selectively with a receptor for corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai] +is_a: GO:0051428 ! peptide hormone receptor binding + +[Term] +id: GO:0051430 +name: corticotropin-releasing hormone receptor 1 binding +namespace: molecular_function +def: "Interacting selectively with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on adrenocorticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857] +synonym: "CRHR1 binding" EXACT [] +is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding + +[Term] +id: GO:0051431 +name: corticotropin-releasing hormone receptor 2 binding +namespace: molecular_function +def: "Interacting selectively with the protein corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857] +synonym: "CRHR2 binding" EXACT [] +is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding + +[Term] +id: GO:0051432 +name: BH1 domain binding +namespace: molecular_function +def: "Interacting selectively with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051433 +name: BH2 domain binding +namespace: molecular_function +def: "Interacting selectively with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051434 +name: BH3 domain binding +namespace: molecular_function +def: "Interacting selectively with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051435 +name: BH4 domain binding +namespace: molecular_function +def: "Interacting selectively with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051436 +name: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai, GOC:tb] +synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW [] +synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW [] +synonym: "APC inhibition during mitotic cell cycle" NARROW [] +synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] +synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] +synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] +synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW [] +synonym: "mitotic anaphase promoting complex inhibition" NARROW [] +synonym: "mitotic anaphase promoting complex inhibitor" NARROW [] +synonym: "mitotic anaphase-promoting complex inhibition" NARROW [] +synonym: "mitotic anaphase-promoting complex inhibitor" NARROW [] +synonym: "mitotic APC inhibition" NARROW [] +synonym: "mitotic APC inhibitor" NARROW [] +synonym: "mitotic SCF complex inhibitor" NARROW [] +synonym: "mitotic ubiquitin ligase inhibitor" NARROW [] +synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb] +xref: Reactome:141405 +xref: Reactome:174079 +xref: Reactome:174084 +xref: Reactome:174097 +xref: Reactome:174139 +xref: Reactome:174235 +xref: Reactome:174251 +xref: Reactome:205333 +xref: Reactome:205338 +xref: Reactome:207432 +xref: Reactome:210208 +xref: Reactome:210209 +xref: Reactome:211754 +xref: Reactome:211831 +xref: Reactome:214680 +xref: Reactome:214685 +xref: Reactome:217035 +xref: Reactome:220042 +xref: Reactome:220043 +xref: Reactome:221521 +xref: Reactome:221596 +xref: Reactome:224156 +xref: Reactome:224161 +xref: Reactome:225859 +xref: Reactome:228630 +xref: Reactome:228631 +xref: Reactome:230140 +xref: Reactome:230196 +xref: Reactome:232620 +xref: Reactome:232625 +xref: Reactome:234526 +xref: Reactome:236793 +xref: Reactome:236794 +xref: Reactome:238166 +xref: Reactome:238230 +xref: Reactome:242235 +xref: Reactome:243841 +xref: Reactome:243842 +xref: Reactome:244755 +xref: Reactome:244807 +xref: Reactome:248864 +xref: Reactome:251887 +xref: Reactome:252478 +xref: Reactome:255069 +xref: Reactome:255640 +xref: Reactome:258367 +xref: Reactome:259034 +xref: Reactome:261840 +xref: Reactome:262399 +xref: Reactome:264678 +xref: Reactome:265238 +xref: Reactome:267832 +xref: Reactome:267834 +xref: Reactome:268363 +xref: Reactome:272160 +xref: Reactome:273334 +xref: Reactome:273335 +xref: Reactome:274029 +xref: Reactome:274074 +xref: Reactome:278147 +xref: Reactome:279794 +xref: Reactome:279795 +xref: Reactome:280507 +xref: Reactome:280548 +xref: Reactome:282372 +xref: Reactome:285037 +xref: Reactome:285935 +xref: Reactome:285936 +xref: Reactome:286529 +xref: Reactome:286565 +is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle +is_a: GO:0051444 ! negative regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051437 +name: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai, GOC:tb] +synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] +synonym: "mitotic SCF complex activator" NARROW [] +synonym: "mitotic ubiquitin ligase activator" NARROW [] +synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb] +synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] +synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] +synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] +synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [] +xref: Reactome:174113 +xref: Reactome:174238 +xref: Reactome:176412 +xref: Reactome:204045 +xref: Reactome:211808 +xref: Reactome:211883 +xref: Reactome:213017 +xref: Reactome:221572 +xref: Reactome:221647 +xref: Reactome:222830 +xref: Reactome:230174 +xref: Reactome:230238 +xref: Reactome:231347 +xref: Reactome:238210 +xref: Reactome:238277 +xref: Reactome:239364 +xref: Reactome:244788 +xref: Reactome:244876 +xref: Reactome:249766 +xref: Reactome:255691 +xref: Reactome:259083 +xref: Reactome:262443 +xref: Reactome:265278 +xref: Reactome:269402 +xref: Reactome:274058 +xref: Reactome:275312 +xref: Reactome:280534 +xref: Reactome:283577 +xref: Reactome:286552 +xref: Reactome:286607 +is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle +is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051438 +name: regulation of ubiquitin-protein ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb] +synonym: "anaphase-promoting complex regulator" NARROW [] +synonym: "APC regulator" NARROW [] +synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:tb] +synonym: "SCF complex regulator" NARROW [] +synonym: "ubiquitin ligase regulator" RELATED [] +synonym: "ubiquitin-protein ligase regulator" RELATED [] +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0051439 +name: regulation of ubiquitin-protein ligase activity during mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai] +synonym: "mitotic anaphase-promoting complex regulator" NARROW [] +synonym: "mitotic APC regulator" NARROW [] +synonym: "mitotic SCF complex regulator" NARROW [] +synonym: "mitotic ubiquitin ligase regulator" RELATED [] +synonym: "mitotic ubiquitin-protein ligase regulator" RELATED [] +synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb] +xref: Reactome:176407 +xref: Reactome:176408 +xref: Reactome:211657 +xref: Reactome:211661 +xref: Reactome:221429 +xref: Reactome:221433 +xref: Reactome:230061 +xref: Reactome:230065 +xref: Reactome:238081 +xref: Reactome:238084 +xref: Reactome:244690 +xref: Reactome:244694 +xref: Reactome:249666 +xref: Reactome:249745 +xref: Reactome:252447 +xref: Reactome:252500 +xref: Reactome:255612 +xref: Reactome:255673 +xref: Reactome:258992 +xref: Reactome:259065 +xref: Reactome:262363 +xref: Reactome:262427 +xref: Reactome:265207 +xref: Reactome:265263 +xref: Reactome:268331 +xref: Reactome:268391 +xref: Reactome:273978 +xref: Reactome:273981 +xref: Reactome:280457 +xref: Reactome:280460 +xref: Reactome:282833 +xref: Reactome:286479 +xref: Reactome:286539 +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0051440 +name: regulation of ubiquitin-protein ligase activity during meiotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [EC:6.3.2.19, GOC:ai, GOC:tb] +synonym: "meiotic anaphase-promoting complex regulator" NARROW [] +synonym: "meiotic APC regulator" NARROW [] +synonym: "meiotic SCF complex regulator" NARROW [] +synonym: "meiotic ubiquitin ligase regulator" RELATED [] +synonym: "meiotic ubiquitin-protein ligase regulator" RELATED [] +synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051441 +name: positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] +synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] +synonym: "meiotic SCF complex activator" NARROW [] +synonym: "meiotic ubiquitin ligase activator" NARROW [] +synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb] +synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] +synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] +synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] +synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] +is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity during meiotic cell cycle +is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051442 +name: negative regulation of ubiquitin-protein ligase activity during meiotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] +synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW [] +synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW [] +synonym: "APC inhibition during meiotic cell cycle" NARROW [] +synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] +synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] +synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [] +synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW [] +synonym: "meiotic anaphase promoting complex inhibition" NARROW [] +synonym: "meiotic anaphase promoting complex inhibitor" NARROW [] +synonym: "meiotic anaphase-promoting complex inhibition" NARROW [] +synonym: "meiotic anaphase-promoting complex inhibitor" NARROW [] +synonym: "meiotic APC inhibition" NARROW [] +synonym: "meiotic APC inhibitor" NARROW [] +synonym: "meiotic SCF complex inhibitor" NARROW [] +synonym: "meiotic ubiquitin ligase inhibitor" NARROW [] +synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb] +is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity during meiotic cell cycle +is_a: GO:0051444 ! negative regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051443 +name: positive regulation of ubiquitin-protein ligase activity +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb] +synonym: "activation of ubiquitin ligase activity" NARROW [] +synonym: "anaphase promoting complex activator" NARROW [] +synonym: "anaphase-promoting complex activator" NARROW [] +synonym: "APC activation" NARROW [] +synonym: "APC activator" NARROW [] +synonym: "positive regulation of ubiquitin ligase activity" EXACT [GOC:tb] +synonym: "SCF complex activator" NARROW [] +synonym: "stimulation of ubiquitin ligase activity" NARROW [] +synonym: "ubiquitin ligase activator" NARROW [] +synonym: "up regulation of ubiquitin ligase activity" EXACT [] +synonym: "up-regulation of ubiquitin ligase activity" EXACT [] +synonym: "upregulation of ubiquitin ligase activity" EXACT [] +is_a: GO:0051351 ! positive regulation of ligase activity +is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051444 +name: negative regulation of ubiquitin-protein ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb] +synonym: "anaphase promoting complex inhibition" NARROW [] +synonym: "anaphase promoting complex inhibitor" NARROW [] +synonym: "anaphase-promoting complex inhibition" NARROW [] +synonym: "anaphase-promoting complex inhibitor" NARROW [] +synonym: "APC inhibition" NARROW [] +synonym: "APC inhibitor" NARROW [] +synonym: "down regulation of ubiquitin ligase activity" EXACT [] +synonym: "down-regulation of ubiquitin ligase activity" EXACT [] +synonym: "downregulation of ubiquitin ligase activity" EXACT [] +synonym: "inhibition of ubiquitin ligase activity" NARROW [] +synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:tb] +synonym: "SCF complex inhibitor" NARROW [] +synonym: "ubiquitin ligase inhibitor" NARROW [] +is_a: GO:0051352 ! negative regulation of ligase activity +is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051445 +name: regulation of meiotic cell cycle +namespace: biological_process +def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "control of meiotic cell cycle progression" EXACT [] +synonym: "meiotic cell cycle control" EXACT [] +synonym: "meiotic cell cycle modulation" EXACT [] +synonym: "meiotic cell cycle regulation" EXACT [] +synonym: "meiotic cell cycle regulator" RELATED [] +synonym: "modulation of meiotic cell cycle progression" EXACT [] +synonym: "regulation of meiotic cell cycle progression" EXACT [] +synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051726 ! regulation of cell cycle +relationship: regulates GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051446 +name: positive regulation of meiotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "activation of progression through meiotic cell cycle" NARROW [] +synonym: "positive regulation of meiotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through meiotic cell cycle" NARROW [] +synonym: "up regulation of progression through meiotic cell cycle" EXACT [] +synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] +synonym: "upregulation of progression through meiotic cell cycle" EXACT [] +is_a: GO:0045787 ! positive regulation of cell cycle +is_a: GO:0051445 ! regulation of meiotic cell cycle +relationship: positively_regulates GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051447 +name: negative regulation of meiotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "down regulation of progression through meiotic cell cycle" EXACT [] +synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] +synonym: "downregulation of progression through meiotic cell cycle" EXACT [] +synonym: "inhibition of progression through meiotic cell cycle" NARROW [] +synonym: "negative regulation of meiotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0045786 ! negative regulation of cell cycle +is_a: GO:0051445 ! regulation of meiotic cell cycle +relationship: negatively_regulates GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051448 +name: gonadotropin-releasing hormone binding +namespace: molecular_function +def: "Interacting selectively with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus." [PMID:1984190] +synonym: "gonadotrophin-releasing hormone binding" EXACT [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0051449 +name: thyrotropin-releasing hormone binding +namespace: molecular_function +def: "Interacting selectively with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0051450 +name: myoblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] +is_a: GO:0008283 ! cell proliferation + +[Term] +id: GO:0051451 +name: myoblast migration +namespace: biological_process +def: "The orderly movement of myoblasts from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] +is_a: GO:0014812 ! muscle cell migration +relationship: part_of GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0051452 +name: intracellular pH reduction +namespace: biological_process +def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] +synonym: "cell pH reduction" EXACT [] +synonym: "cellular acidification" EXACT [] +synonym: "intracellular acidification" RELATED [] +synonym: "reduction of cellular pH" EXACT [] +synonym: "reduction of pH in cell" EXACT [] +is_a: GO:0045851 ! pH reduction +is_a: GO:0051453 ! regulation of intracellular pH + +[Term] +id: GO:0051453 +name: regulation of intracellular pH +namespace: biological_process +def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb] +synonym: "cell pH regulation" EXACT [] +synonym: "cellular pH regulation" EXACT [] +synonym: "pH regulation in cell" EXACT [] +synonym: "regulation of cell pH" EXACT [] +is_a: GO:0030641 ! regulation of cellular pH + +[Term] +id: GO:0051454 +name: intracellular pH elevation +namespace: biological_process +def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] +synonym: "cell pH elevation" EXACT [] +synonym: "cellular alkalinization" EXACT [] +synonym: "elevation of cellular pH" EXACT [] +synonym: "intracellular alkalinization" EXACT [] +synonym: "pH elevation in cell" EXACT [] +is_a: GO:0045852 ! pH elevation +is_a: GO:0051453 ! regulation of intracellular pH + +[Term] +id: GO:0051455 +name: attachment of spindle microtubules to kinetochore during meiosis I +namespace: biological_process +def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt] +comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. +synonym: "monopolar attachment" EXACT [] +synonym: "sister kinetochore monoorientation" EXACT [] +is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0051456 +name: attachment of spindle microtubules to kinetochore during meiosis II +namespace: biological_process +def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt] +is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0051457 +name: maintenance of protein location in nucleus +namespace: biological_process +def: "Any process by which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] +synonym: "maintenance of nuclear protein localization" EXACT [] +synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protein location in cell nucleus" EXACT [] +synonym: "nuclear protein retention" NARROW [] +synonym: "nuclear protein sequestering" NARROW [] +synonym: "nuclear protein sequestration" NARROW [] +synonym: "protein retention in nucleus" NARROW [] +synonym: "protein sequestration in nucleus" NARROW [] +synonym: "protein storage in nucleus" NARROW [] +synonym: "protein-nuclear retention" NARROW [] +synonym: "sequestration of protein in nucleus" NARROW [] +synonym: "storage of protein in nucleus" NARROW [] +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0051458 +name: adrenocorticotropin hormone secretion +namespace: biological_process +def: "The regulated release of adrenocorticotropin hormone, also known as corticotropin, by a cell or group of cells. Adrenocorticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [PMID:11027914] +synonym: "adrenocorticotropic hormone secretion" EXACT [] +synonym: "adrenotropic hormone secretion" EXACT [] +synonym: "adrenotropin secretion" EXACT [] +synonym: "ATCH secretion" EXACT [] +synonym: "corticotropic hormone secretion" EXACT [] +synonym: "corticotropin secretion" EXACT [] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0051459 +name: regulation of adrenocorticotropin hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells." [GOC:ai, GOC:dph] +synonym: "regulation of adrenocorticotropic hormone secreteion" EXACT [GOC:dph] +synonym: "regulation of adrenocorticotropin secretion" EXACT [] +synonym: "regulation of adrenotropin hormone secretion" EXACT [] +synonym: "regulation of adrenotropin secretion" EXACT [] +synonym: "regulation of ATCH secretion" EXACT [] +synonym: "regulation of corticotropic hormone secretion" EXACT [] +synonym: "regulation of corticotropin secretion" EXACT [] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0051458 ! adrenocorticotropin hormone secretion + +[Term] +id: GO:0051460 +name: negative regulation of adrenocorticotropic hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells." [GOC:ai] +synonym: "down regulation of adrenocorticotropin hormone secretion" EXACT [] +synonym: "down-regulation of adrenocorticotropin hormone secretion" EXACT [] +synonym: "downregulation of adrenocorticotropin hormone secretion" EXACT [] +synonym: "inhibition of adrenocorticotropin hormone secretion" NARROW [] +synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] +synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] +synonym: "negative regulation of adrenotropin secretion" EXACT [] +synonym: "negative regulation of ATCH secretion" EXACT [] +synonym: "negative regulation of corticotropic hormone secretion" EXACT [] +synonym: "negative regulation of corticotropin secretion" EXACT [] +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051459 ! regulation of adrenocorticotropin hormone secretion +relationship: negatively_regulates GO:0051458 ! adrenocorticotropin hormone secretion + +[Term] +id: GO:0051461 +name: positive regulation of adrenocorticotropic hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells." [GOC:ai] +synonym: "activation of adrenocorticotropin hormone secretion" NARROW [] +synonym: "positive regulation of adrenocorticotropin secretion" EXACT [] +synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] +synonym: "positive regulation of adrenotropin secretion" EXACT [] +synonym: "positive regulation of ATCH secretion" EXACT [] +synonym: "positive regulation of corticotropic hormone secretion" EXACT [] +synonym: "positive regulation of corticotropin secretion" EXACT [] +synonym: "stimulation of adrenocorticotropin hormone secretion" NARROW [] +synonym: "up regulation of adrenocorticotropin hormone secretion" EXACT [] +synonym: "up-regulation of adrenocorticotropin hormone secretion" EXACT [] +synonym: "upregulation of adrenocorticotropin hormone secretion" EXACT [] +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0051459 ! regulation of adrenocorticotropin hormone secretion +relationship: positively_regulates GO:0051458 ! adrenocorticotropin hormone secretion + +[Term] +id: GO:0051462 +name: regulation of cortisol secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0043400 ! cortisol secretion + +[Term] +id: GO:0051463 +name: negative regulation of cortisol secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai] +synonym: "down regulation of cortisol secretion" EXACT [] +synonym: "down-regulation of cortisol secretion" EXACT [] +synonym: "downregulation of cortisol secretion" EXACT [] +synonym: "inhibition of cortisol secretion" NARROW [] +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051462 ! regulation of cortisol secretion +relationship: negatively_regulates GO:0043400 ! cortisol secretion + +[Term] +id: GO:0051464 +name: positive regulation of cortisol secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai] +synonym: "activation of cortisol secretion" NARROW [] +synonym: "stimulation of cortisol secretion" NARROW [] +synonym: "up regulation of cortisol secretion" EXACT [] +synonym: "up-regulation of cortisol secretion" EXACT [] +synonym: "upregulation of cortisol secretion" EXACT [] +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0051462 ! regulation of cortisol secretion +relationship: positively_regulates GO:0043400 ! cortisol secretion + +[Term] +id: GO:0051465 +name: negative regulation of corticotropin-releasing hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells." [GOC:ai] +synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW [] +synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT [] +synonym: "negative regulation of CRF secretion" EXACT [] +synonym: "negative regulation of CRH secretion" EXACT [] +is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion + +[Term] +id: GO:0051466 +name: positive regulation of corticotropin-releasing hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells." [GOC:ai] +synonym: "activation of corticotropin-releasing hormone secretion" NARROW [] +synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT [] +synonym: "positive regulation of CRF secretion" EXACT [] +synonym: "positive regulation of CRH secretion" EXACT [] +synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW [] +synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT [] +is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion + +[Term] +id: GO:0051467 +name: detection of steroid hormone stimulus +namespace: biological_process +def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0048545 ! response to steroid hormone stimulus + +[Term] +id: GO:0051468 +name: detection of glucocorticoid hormone stimulus +namespace: biological_process +def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai] +is_a: GO:0051384 ! response to glucocorticoid stimulus +is_a: GO:0051467 ! detection of steroid hormone stimulus + +[Term] +id: GO:0051469 +name: vesicle fusion with vacuole +namespace: biological_process +alt_id: GO:0042146 +def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] +synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] +synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0007033 ! vacuole organization + +[Term] +id: GO:0051470 +name: ectoine transport +namespace: biological_process +def: "The directed movement of ectoine into, out of, within or between cells. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] +subset: gosubset_prok +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0051471 +name: ectoine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of ectoine from one side of the membrane to the other. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] +subset: gosubset_prok +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0051472 +name: glucosylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] +synonym: "glucosylglycerol metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process + +[Term] +id: GO:0051473 +name: glucosylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] +synonym: "glucosylglycerol anabolism" EXACT [] +synonym: "glucosylglycerol biosynthesis" EXACT [] +synonym: "glucosylglycerol formation" EXACT [] +synonym: "glucosylglycerol synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0051472 ! glucosylglycerol metabolic process + +[Term] +id: GO:0051474 +name: glucosylglycerol transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosylglycerol from one side of the membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0051475 +name: glucosylglycerol transport +namespace: biological_process +def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of, within or between cells." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0051476 +name: mannosylglycerate transport +namespace: biological_process +def: "The directed movement of mannosylglycerate into, out of, within or between cells." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0051477 +name: mannosylglycerate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannosylglycerate from one side of the membrane to the other." [GOC:ai, PMID:15034926] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0051478 +name: mannosylglycerate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374] +synonym: "mannosylglycerate metabolism" EXACT [] +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0051479 +name: mannosylglycerate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai] +synonym: "mannosylglycerate anabolism" EXACT [] +synonym: "mannosylglycerate biosynthesis" EXACT [] +synonym: "mannosylglycerate formation" EXACT [] +synonym: "mannosylglycerate synthesis" EXACT [] +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0051478 ! mannosylglycerate metabolic process + +[Term] +id: GO:0051480 +name: cytosolic calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai] +synonym: "calcium ion homeostasis in cytoplasm" BROAD [] +synonym: "calcium ion homeostasis in cytosol" EXACT [] +synonym: "cytoplasmic calcium ion concentration regulation" BROAD [] +synonym: "cytoplasmic calcium ion homeostasis" BROAD [] +synonym: "cytosolic calcium ion concentration regulation" EXACT [] +synonym: "regulation of calcium ion concentration in cytoplasm" BROAD [] +synonym: "regulation of calcium ion concentration in cytosol" EXACT [] +synonym: "regulation of cytoplasmic calcium ion concentration" BROAD [] +synonym: "regulation of cytosolic calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0051481 +name: reduction of cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the cytodol." [GOC:ai] +synonym: "cytoplasmic calcium ion concentration reduction" BROAD [] +synonym: "cytosolic calcium ion concentration reduction" EXACT [] +synonym: "reduction of calcium ion concentration in cytoplasm" BROAD [] +synonym: "reduction of calcium ion concentration in cytosol" EXACT [] +synonym: "reduction of cytoplasmic calcium ion concentration" BROAD [] +is_a: GO:0051480 ! cytosolic calcium ion homeostasis + +[Term] +id: GO:0051482 +name: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger." [GOC:ai] +synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] +synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] +synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] +synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration +relationship: part_of GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) + +[Term] +id: GO:0051483 +name: terpenoid biosynthetic process, mevalonate-independent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] +synonym: "mevalonate-independent terpene biosynthesis" NARROW [] +synonym: "mevalonate-independent terpene biosynthetic process" NARROW [] +synonym: "mevalonate-independent terpenoid biosynthesis" EXACT [] +synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT [] +synonym: "terpene biosynthesis, mevalonate-independent" NARROW [] +synonym: "terpene biosynthetic process, mevalonate-independent" NARROW [] +synonym: "terpenoid anabolism, mevalonate-independent" EXACT [] +synonym: "terpenoid formation, mevalonate-independent" EXACT [] +synonym: "terpenoid synthesis, mevalonate-independent" EXACT [] +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0051484 +name: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway during terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] +synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" EXACT [] +synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" EXACT [] +xref: MetaCyc:NONMEVIPP-PWY +is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway +relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent + +[Term] +id: GO:0051485 +name: terpenoid biosynthetic process, mevalonate-dependent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] +synonym: "terpene biosynthesis, mevalonate-dependent" NARROW [] +synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW [] +synonym: "terpenoid anabolism, mevalonate-dependent" EXACT [] +synonym: "terpenoid formation, mevalonate-dependent" EXACT [] +synonym: "terpenoid synthesis, mevalonate-dependent" EXACT [] +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0051486 +name: isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway during terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] +synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" EXACT [] +synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" EXACT [] +is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway +relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent + +[Term] +id: GO:0051487 +name: activation of anaphase-promoting complex during meiotic cell cycle +namespace: biological_process +def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] +synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" EXACT [] +synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" EXACT [] +synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" EXACT [] +synonym: "anaphase promoting complex activation during meiotic cell cycle" EXACT [] +synonym: "anaphase-promoting complex activation during meiotic cell cycle" EXACT [] +synonym: "APC activation during meiotic cell cycle" EXACT [] +synonym: "meiotic anaphase promoting complex activation" EXACT [] +synonym: "meiotic anaphase promoting complex activator" NARROW [] +synonym: "meiotic anaphase-promoting complex activator" NARROW [] +synonym: "meiotic APC activation" EXACT [] +synonym: "meiotic APC activator" NARROW [] +is_a: GO:0051441 ! positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle +is_a: GO:0051488 ! activation of anaphase-promoting complex + +[Term] +id: GO:0051488 +name: activation of anaphase-promoting complex +namespace: biological_process +def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] +synonym: "activation of ubiquitin ligase activity of anaphase promoting complex" EXACT [] +synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex" EXACT [] +synonym: "activation of ubiquitin ligase activity of APC" EXACT [] +synonym: "anaphase promoting complex activation" EXACT [] +synonym: "anaphase promoting complex activator" NARROW [] +synonym: "anaphase-promoting complex activation" EXACT [] +synonym: "anaphase-promoting complex activator" NARROW [] +synonym: "APC activation" EXACT [] +synonym: "APC activator" NARROW [] +is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity + +[Term] +id: GO:0051489 +name: regulation of filopodium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai] +synonym: "regulation of filopodia biosynthesis" EXACT [] +synonym: "regulation of filopodia formation" EXACT [] +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0046847 ! filopodium formation + +[Term] +id: GO:0051490 +name: negative regulation of filopodium formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai] +synonym: "down regulation of filopodium formation" EXACT [] +synonym: "down-regulation of filopodium formation" EXACT [] +synonym: "downregulation of filopodium formation" EXACT [] +synonym: "inhibition of filopodium formation" NARROW [] +synonym: "negative regulation of filopodia biosynthesis" EXACT [] +synonym: "negative regulation of filopodia formation" EXACT [] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0051489 ! regulation of filopodium formation +relationship: negatively_regulates GO:0046847 ! filopodium formation + +[Term] +id: GO:0051491 +name: positive regulation of filopodium formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai] +synonym: "activation of filopodium formation" NARROW [] +synonym: "positive regulation of filopodia biosynthesis" EXACT [] +synonym: "positive regulation of filopodia formation" EXACT [] +synonym: "stimulation of filopodium formation" NARROW [] +synonym: "up regulation of filopodium formation" EXACT [] +synonym: "up-regulation of filopodium formation" EXACT [] +synonym: "upregulation of filopodium formation" EXACT [] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0051489 ! regulation of filopodium formation +relationship: positively_regulates GO:0046847 ! filopodium formation + +[Term] +id: GO:0051492 +name: regulation of stress fiber formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] +synonym: "regulation of stress fibre biosynthesis" EXACT [] +synonym: "regulation of stress fibre formation" EXACT [] +is_a: GO:0032231 ! regulation of actin filament bundle formation +relationship: regulates GO:0043149 ! stress fiber formation + +[Term] +id: GO:0051493 +name: regulation of cytoskeleton organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] +synonym: "regulation of cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0051494 +name: negative regulation of cytoskeleton organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] +synonym: "down regulation of cytoskeleton organization and biogenesis" EXACT [] +synonym: "down-regulation of cytoskeleton organization and biogenesis" EXACT [] +synonym: "downregulation of cytoskeleton organization and biogenesis" EXACT [] +synonym: "inhibition of cytoskeleton organization and biogenesis" NARROW [] +synonym: "negative regulation of cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: negatively_regulates GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0051495 +name: positive regulation of cytoskeleton organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] +synonym: "activation of cytoskeleton organization and biogenesis" NARROW [] +synonym: "positive regulation of cytoskeleton organization and biogenesis" EXACT [] +synonym: "stimulation of cytoskeleton organization and biogenesis" NARROW [] +synonym: "up regulation of cytoskeleton organization and biogenesis" EXACT [] +synonym: "up-regulation of cytoskeleton organization and biogenesis" EXACT [] +synonym: "upregulation of cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: positively_regulates GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0051496 +name: positive regulation of stress fiber formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] +synonym: "activation of stress fiber formation" NARROW [] +synonym: "positive regulation of stress fibre biosynthesis" EXACT [] +synonym: "positive regulation of stress fibre formation" EXACT [] +synonym: "stimulation of stress fiber formation" NARROW [] +synonym: "up regulation of stress fiber formation" EXACT [] +synonym: "up-regulation of stress fiber formation" EXACT [] +synonym: "upregulation of stress fiber formation" EXACT [] +is_a: GO:0032233 ! positive regulation of actin filament bundle formation +is_a: GO:0051492 ! regulation of stress fiber formation +relationship: positively_regulates GO:0043149 ! stress fiber formation + +[Term] +id: GO:0051497 +name: negative regulation of stress fiber formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] +synonym: "down regulation of stress fiber formation" EXACT [] +synonym: "down-regulation of stress fiber formation" EXACT [] +synonym: "downregulation of stress fiber formation" EXACT [] +synonym: "inhibition of stress fiber formation" NARROW [] +synonym: "negative regulation of stress fibre biosynthesis" EXACT [] +synonym: "negative regulation of stress fibre formation" EXACT [] +is_a: GO:0032232 ! negative regulation of actin filament bundle formation +is_a: GO:0051492 ! regulation of stress fiber formation +relationship: negatively_regulates GO:0043149 ! stress fiber formation + +[Term] +id: GO:0051498 +name: syn-copalyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = syn-copalyl diphosphate." [MetaCyc:RXN-4861] +synonym: "diterpene cyclase activity" BROAD [] +xref: MetaCyc:RXN-4861 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0051499 +name: D-aminoacyl-tRNA deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667] +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0051500 +name: D-tyrosyl-tRNA(Tyr) deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine resides in charged tRNA." [PMID:14527667] +is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity + +[Term] +id: GO:0051501 +name: diterpene phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, http://www.onelook.com, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "diterpene phytoalexin metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0051502 +name: diterpene phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai] +synonym: "diterpene phytoalexin anabolism" EXACT [] +synonym: "diterpene phytoalexin biosynthesis" EXACT [] +synonym: "diterpene phytoalexin formation" EXACT [] +synonym: "diterpene phytoalexin synthesis" EXACT [] +is_a: GO:0051501 ! diterpene phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0051503 +name: adenine nucleotide transport +namespace: biological_process +def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of, within or between cells." [GOC:ai] +is_a: GO:0015865 ! purine nucleotide transport + +[Term] +id: GO:0051504 +name: diterpene phytoalexin precursor biosynthetic process pathway +namespace: biological_process +def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981] +synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT [] +synonym: "diterpene phytoalexin precursor formation pathway" EXACT [] +synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT [] +xref: MetaCyc:PWY-2981 +is_a: GO:0046246 ! terpene biosynthetic process +relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process + +[Term] +id: GO:0051505 +name: cholesterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol." [GOC:ai] +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051506 +name: ergosterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol." [GOC:ai] +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051507 +name: beta-sitosterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai] +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051508 +name: stigmasterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol." [GOC:ai] +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051509 +name: tomatidine UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine." [GOC:ai] +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051510 +name: regulation of unidimensional cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] +is_a: GO:0001558 ! regulation of cell growth +relationship: regulates GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0051511 +name: negative regulation of unidimensional cell growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] +synonym: "down regulation of unidimensional cell growth" EXACT [] +synonym: "down-regulation of unidimensional cell growth" EXACT [] +synonym: "downregulation of unidimensional cell growth" EXACT [] +synonym: "inhibition of unidimensional cell growth" NARROW [] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: negatively_regulates GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0051512 +name: positive regulation of unidimensional cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] +synonym: "activation of unidimensional cell growth" NARROW [] +synonym: "stimulation of unidimensional cell growth" NARROW [] +synonym: "up regulation of unidimensional cell growth" EXACT [] +synonym: "up-regulation of unidimensional cell growth" EXACT [] +synonym: "upregulation of unidimensional cell growth" EXACT [] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: positively_regulates GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0051513 +name: regulation of monopolar cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: regulates GO:0042814 ! monopolar cell growth + +[Term] +id: GO:0051514 +name: negative regulation of monopolar cell growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +synonym: "down regulation of monopolar cell growth" EXACT [] +synonym: "down-regulation of monopolar cell growth" EXACT [] +synonym: "downregulation of monopolar cell growth" EXACT [] +synonym: "inhibition of monopolar cell growth" NARROW [] +is_a: GO:0051511 ! negative regulation of unidimensional cell growth +is_a: GO:0051513 ! regulation of monopolar cell growth +relationship: negatively_regulates GO:0042814 ! monopolar cell growth + +[Term] +id: GO:0051515 +name: positive regulation of monopolar cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +synonym: "stimulation of monopolar cell growth" NARROW [] +synonym: "up regulation of monopolar cell growth" EXACT [] +synonym: "up-regulation of monopolar cell growth" EXACT [] +synonym: "upregulation of monopolar cell growth" EXACT [] +is_a: GO:0051512 ! positive regulation of unidimensional cell growth +is_a: GO:0051513 ! regulation of monopolar cell growth +relationship: positively_regulates GO:0042814 ! monopolar cell growth + +[Term] +id: GO:0051516 +name: regulation of bipolar cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: regulates GO:0042815 ! bipolar cell growth + +[Term] +id: GO:0051517 +name: negative regulation of bipolar cell growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +synonym: "down regulation of bipolar cell growth" EXACT [] +synonym: "down-regulation of bipolar cell growth" EXACT [] +synonym: "downregulation of bipolar cell growth" EXACT [] +synonym: "inhibition of bipolar cell growth" NARROW [] +is_a: GO:0051511 ! negative regulation of unidimensional cell growth +is_a: GO:0051516 ! regulation of bipolar cell growth +relationship: negatively_regulates GO:0042815 ! bipolar cell growth + +[Term] +id: GO:0051518 +name: positive regulation of bipolar cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +synonym: "stimulation of bipolar cell growth" NARROW [] +synonym: "up regulation of bipolar cell growth" EXACT [] +synonym: "up-regulation of bipolar cell growth" EXACT [] +synonym: "upregulation of bipolar cell growth" EXACT [] +is_a: GO:0051512 ! positive regulation of unidimensional cell growth +is_a: GO:0051516 ! regulation of bipolar cell growth +relationship: positively_regulates GO:0042815 ! bipolar cell growth + +[Term] +id: GO:0051519 +name: activation of bipolar cell growth +namespace: biological_process +def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +synonym: "NETO" NARROW [] +synonym: "new end take off" NARROW [] +synonym: "new end take-off" NARROW [] +is_a: GO:0051518 ! positive regulation of bipolar cell growth + +[Term] +id: GO:0051520 +name: termination of bipolar cell growth +namespace: biological_process +def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +is_a: GO:0051517 ! negative regulation of bipolar cell growth + +[Term] +id: GO:0051521 +name: termination of monopolar cell growth +namespace: biological_process +def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai] +is_a: GO:0051514 ! negative regulation of monopolar cell growth + +[Term] +id: GO:0051522 +name: activation of monopolar cell growth +namespace: biological_process +def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +is_a: GO:0051515 ! positive regulation of monopolar cell growth + +[Term] +id: GO:0051523 +name: cell growth mode switching, monopolar to bipolar +namespace: biological_process +def: "The process by which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai] +is_a: GO:0051510 ! regulation of unidimensional cell growth + +[Term] +id: GO:0051524 +name: cell growth mode switch, bipolar to monopolar +namespace: biological_process +def: "The process by which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai] +is_a: GO:0051510 ! regulation of unidimensional cell growth + +[Term] +id: GO:0051525 +name: NFAT protein binding +namespace: molecular_function +def: "Interacting selectively with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679] +synonym: "NFAT binding" EXACT [] +synonym: "nuclear factor of activated T cell protein binding" EXACT [] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0051526 +name: NFAT1 protein binding +namespace: molecular_function +def: "Interacting selectively with NFAT1 (nuclear factor of activated T cells 1 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] +synonym: "NFATc2 binding" EXACT [] +synonym: "NFATp binding" EXACT [] +is_a: GO:0051525 ! NFAT protein binding + +[Term] +id: GO:0051527 +name: NFAT2 protein binding +namespace: molecular_function +def: "Interacting selectively with NFAT2 (nuclear factor of activated T cells 2 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] +synonym: "NFATc binding" EXACT [] +synonym: "NFATc1 binding" EXACT [] +is_a: GO:0051525 ! NFAT protein binding + +[Term] +id: GO:0051528 +name: NFAT3 protein binding +namespace: molecular_function +def: "Interacting selectively with NFAT3 (nuclear factor of activated T cells 3 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] +synonym: "NFATc4 binding" EXACT [] +is_a: GO:0051525 ! NFAT protein binding + +[Term] +id: GO:0051529 +name: NFAT4 protein binding +namespace: molecular_function +def: "Interacting selectively with NFAT4 (nuclear factor of activated T cells 4 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai] +synonym: "NFATc3 binding" RELATED [] +synonym: "NFATx binding" EXACT [] +is_a: GO:0051525 ! NFAT protein binding + +[Term] +id: GO:0051530 +name: NFAT5 protein binding +namespace: molecular_function +def: "Interacting selectively with NFAT1 (nuclear factor of activated T cells 1 protein), a member of the NFAT transcription factor family which is not calcium regulated." [GOC:ai] +synonym: "non-calcium-regulated NFAT protein binding" EXACT [] +is_a: GO:0051525 ! NFAT protein binding + +[Term] +id: GO:0051531 +name: NFAT protein import into nucleus +namespace: biological_process +def: "The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane." [PMID:11983154, PMID:15870113, PMID:15928679] +synonym: "NFAT protein import into cell nucleus" EXACT [] +synonym: "NFAT protein nuclear translocation" EXACT [] +synonym: "NFAT protein nucleus import" EXACT [] +synonym: "NFAT protein transport from cytoplasm to nucleus" EXACT [] +synonym: "NFAT protein-nucleus import" EXACT [] +is_a: GO:0042991 ! transcription factor import into nucleus + +[Term] +id: GO:0051532 +name: regulation of NFAT protein import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] +synonym: "regulation of NFAT protein import into cell nucleus" EXACT [] +synonym: "regulation of NFAT protein transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of NFAT protein-nucleus import" EXACT [] +is_a: GO:0042990 ! regulation of transcription factor import into nucleus +relationship: regulates GO:0051531 ! NFAT protein import into nucleus + +[Term] +id: GO:0051533 +name: positive regulation of NFAT protein import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] +synonym: "activation of NFAT protein import into nucleus" NARROW [] +synonym: "positive regulation of NFAT protein import into cell nucleus" EXACT [] +synonym: "positive regulation of NFAT protein transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of NFAT protein-nucleus import" EXACT [] +synonym: "stimulation of NFAT protein import into nucleus" NARROW [] +synonym: "up regulation of NFAT protein import into nucleus" EXACT [] +synonym: "up-regulation of NFAT protein import into nucleus" EXACT [] +synonym: "upregulation of NFAT protein import into nucleus" EXACT [] +is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus +is_a: GO:0051532 ! regulation of NFAT protein import into nucleus +relationship: positively_regulates GO:0051531 ! NFAT protein import into nucleus + +[Term] +id: GO:0051534 +name: negative regulation of NFAT protein import into nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai] +synonym: "down regulation of NFAT protein import into nucleus" EXACT [] +synonym: "down-regulation of NFAT protein import into nucleus" EXACT [] +synonym: "downregulation of NFAT protein import into nucleus" EXACT [] +synonym: "inhibition of NFAT protein import into nucleus" NARROW [] +synonym: "negative regulation of NFAT protein import into cell nucleus" EXACT [] +synonym: "negative regulation of NFAT protein transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of NFAT protein-nucleus import" EXACT [] +is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus +is_a: GO:0051532 ! regulation of NFAT protein import into nucleus +relationship: negatively_regulates GO:0051531 ! NFAT protein import into nucleus + +[Term] +id: GO:0051535 +name: syntaxin-5 binding +namespace: molecular_function +def: "Interacting selectively with the SNAP receptor syntaxin-5." [GOC:ai, PMID:12388752] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0051536 +name: iron-sulfur cluster binding +namespace: molecular_function +def: "Interacting selectively with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] +synonym: "Fe/S binding" EXACT [] +synonym: "iron sulfur cluster binding" EXACT [] +synonym: "iron sulphur cluster binding" EXACT [] +synonym: "iron-sulphur cluster binding" EXACT [] +is_a: GO:0051540 ! metal cluster binding + +[Term] +id: GO:0051537 +name: 2 iron, 2 sulfur cluster binding +namespace: molecular_function +def: "Interacting selectively with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, http://en.wikipedia.org/wiki/Iron-sulfur_cluster] +synonym: "2 Fe 2 S cluster binding" EXACT [] +synonym: "2 iron, 2 sulphur cluster binding" EXACT [] +synonym: "2Fe-2S cluster binding" EXACT [] +synonym: "diiron disulfide cluster binding" EXACT [] +synonym: "diiron disulphide cluster binding" EXACT [] +synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT [] +synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:0051538 +name: 3 iron, 4 sulfur cluster binding +namespace: molecular_function +def: "Interacting selectively with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, http://en.wikipedia.org/wiki/Iron-sulfur_cluster] +synonym: "3 Fe 4 S cluster binding" EXACT [] +synonym: "3 iron, 4 sulphur cluster binding" EXACT [] +synonym: "3Fe-4S cluster binding" EXACT [] +synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT [] +synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT [] +synonym: "triiron tetrasulfide cluster binding" EXACT [] +synonym: "triiron tetrasulphide cluster binding" EXACT [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:0051539 +name: 4 iron, 4 sulfur cluster binding +namespace: molecular_function +def: "Interacting selectively with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, http://en.wikipedia.org/wiki/Iron-sulfur_cluster] +synonym: "4 Fe 4 S cluster binding" EXACT [] +synonym: "4 iron, 4 sulphur cluster binding" EXACT [] +synonym: "4Fe-4S cluster binding" EXACT [] +synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT [] +synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT [] +synonym: "tetrairon tetrasulfide cluster binding" EXACT [] +synonym: "tetrairon tetrasulphide cluster binding" EXACT [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:0051540 +name: metal cluster binding +namespace: molecular_function +def: "Interacting selectively with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0051541 +name: elastin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and cross linked to form elastic fibres that are found in connective tissue." [http://www.onelook.com] +synonym: "elastin metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0051542 +name: elastin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai] +is_a: GO:0009101 ! glycoprotein biosynthetic process +is_a: GO:0051541 ! elastin metabolic process + +[Term] +id: GO:0051543 +name: regulation of elastin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0051542 ! elastin biosynthetic process + +[Term] +id: GO:0051544 +name: positive regulation of elastin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] +synonym: "activation of elastin biosynthetic process" NARROW [] +synonym: "stimulation of elastin biosynthetic process" NARROW [] +synonym: "up regulation of elastin biosynthetic process" EXACT [] +synonym: "up-regulation of elastin biosynthetic process" EXACT [] +synonym: "upregulation of elastin biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0051543 ! regulation of elastin biosynthetic process +relationship: positively_regulates GO:0051542 ! elastin biosynthetic process + +[Term] +id: GO:0051545 +name: negative regulation of elastin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] +synonym: "down regulation of elastin biosynthetic process" EXACT [] +synonym: "down-regulation of elastin biosynthetic process" EXACT [] +synonym: "downregulation of elastin biosynthetic process" EXACT [] +synonym: "inhibition of elastin biosynthetic process" NARROW [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0051543 ! regulation of elastin biosynthetic process +relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process + +[Term] +id: GO:0051546 +name: keratinocyte migration +namespace: biological_process +def: "The directed movement of keratinocytes, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0051547 +name: regulation of keratinocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0051546 ! keratinocyte migration + +[Term] +id: GO:0051548 +name: negative regulation of keratinocyte migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai] +synonym: "down regulation of keratinocyte migration" EXACT [] +synonym: "down-regulation of keratinocyte migration" EXACT [] +synonym: "downregulation of keratinocyte migration" EXACT [] +synonym: "inhibition of keratinocyte migration" NARROW [] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0051547 ! regulation of keratinocyte migration +relationship: negatively_regulates GO:0051546 ! keratinocyte migration + +[Term] +id: GO:0051549 +name: positive regulation of keratinocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai] +synonym: "activation of keratinocyte migration" NARROW [] +synonym: "stimulation of keratinocyte migration" NARROW [] +synonym: "up regulation of keratinocyte migration" EXACT [] +synonym: "up-regulation of keratinocyte migration" EXACT [] +synonym: "upregulation of keratinocyte migration" EXACT [] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0051547 ! regulation of keratinocyte migration +relationship: positively_regulates GO:0051546 ! keratinocyte migration + +[Term] +id: GO:0051550 +name: aurone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [http://cancerweb.ncl.ac.uk/] +synonym: "aurone metabolism" EXACT [] +synonym: "benzalcoumaran-3-one metabolic process" EXACT [] +synonym: "benzalcoumaran-3-one metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0051551 +name: aurone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai] +synonym: "benzalcoumaran-3-one biosynthesis" EXACT [] +synonym: "benzalcoumaran-3-one biosynthetic process" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051550 ! aurone metabolic process + +[Term] +id: GO:0051552 +name: flavone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [http://www.onelook.com] +synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW [] +synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW [] +synonym: "2-phenylchromone metabolic process" NARROW [] +synonym: "2-phenylchromone metabolism" NARROW [] +synonym: "flavone metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0051553 +name: flavone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai] +synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW [] +synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW [] +synonym: "2-phenylchromone biosynthesis" NARROW [] +synonym: "2-phenylchromone biosynthetic process" NARROW [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051552 ! flavone metabolic process + +[Term] +id: GO:0051554 +name: flavonol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179] +synonym: "flavonol metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0051555 +name: flavonol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai] +xref: MetaCyc:PWY-3101 +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051554 ! flavonol metabolic process + +[Term] +id: GO:0051556 +name: leucoanthocyanidin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] +synonym: "leucoanthocyanidin metabolism" EXACT [] +xref: MetaCyc:PWY1F-823 +is_a: GO:0009812 ! flavonoid metabolic process + +[Term] +id: GO:0051557 +name: leucoanthocyanidin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0051556 ! leucoanthocyanidin metabolic process + +[Term] +id: GO:0051558 +name: phlobaphene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] +synonym: "phlobaphene metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0051559 +name: phlobaphene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051558 ! phlobaphene metabolic process + +[Term] +id: GO:0051560 +name: mitochondrial calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai] +synonym: "calcium ion homeostasis in mitochondria" EXACT [] +synonym: "calcium ion homeostasis in mitochondrion" EXACT [] +synonym: "mitochondrial calcium ion concentration regulation" EXACT [] +synonym: "regulation of calcium ion concentration in mitochondria" EXACT [] +synonym: "regulation of calcium ion concentration in mitochondrion" EXACT [] +synonym: "regulation of mitochondrial calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0051561 +name: elevation of mitochondrial calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai] +synonym: "elevation of calcium ion concentration in mitochondria" EXACT [] +synonym: "elevation of calcium ion concentration in mitochondrion" EXACT [] +synonym: "mitochondrial calcium ion concentration elevation" EXACT [] +is_a: GO:0051560 ! mitochondrial calcium ion homeostasis + +[Term] +id: GO:0051562 +name: reduction of mitochondrial calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai] +synonym: "mitochondrial calcium ion concentration reduction" EXACT [] +synonym: "reduction of calcium ion concentration in mitochondria" EXACT [] +synonym: "reduction of calcium ion concentration in mitochondrion" EXACT [] +is_a: GO:0051560 ! mitochondrial calcium ion homeostasis + +[Term] +id: GO:0051563 +name: smooth endoplasmic reticulum calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai] +synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT [] +synonym: "calcium ion homeostasis in smooth ER" EXACT [] +synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] +synonym: "regulation of calcium ion concentration in smooth ER" EXACT [] +synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "regulation of smooth ER calcium ion concentration" EXACT [] +synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT [] +synonym: "smooth ER calcium ion concentration regulation" EXACT [] +synonym: "smooth ER calcium ion homeostasis" EXACT [] +is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0051564 +name: elevation of smooth endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] +synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] +synonym: "elevation of smooth ER calcium ion concentration" EXACT [] +synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT [] +is_a: GO:0032470 ! elevation of endoplasmic reticulum calcium ion concentration +is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0051565 +name: reduction of smooth endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] +synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] +synonym: "reduction of calcium ion concentration in smooth ER" EXACT [] +synonym: "reduction of smooth ER calcium ion concentration" EXACT [] +synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT [] +synonym: "smooth ER calcium ion concentration reduction" EXACT [] +is_a: GO:0032471 ! reduction of endoplasmic reticulum calcium ion concentration +is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0051566 +name: anthocyanidin-3-glucoside rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800] +synonym: "3RT activity" BROAD [] +synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT [] +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + +[Term] +id: GO:0051567 +name: histone H3-K9 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai] +synonym: "histone H3 K9 methylation" EXACT [] +synonym: "histone H3K9me" EXACT [] +synonym: "histone lysine H3 K9 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0051568 +name: histone H3-K4 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] +synonym: "histone H3 K4 methylation" EXACT [] +synonym: "histone H3K4me" EXACT [] +synonym: "histone lysine H3 K4 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0051569 +name: regulation of histone H3-K4 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0051570 +name: regulation of histone H3-K9 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0051571 +name: positive regulation of histone H3-K4 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] +synonym: "activation of histone H3-K4 methylation" NARROW [] +synonym: "stimulation of histone H3-K4 methylation" NARROW [] +synonym: "up regulation of histone H3-K4 methylation" EXACT [] +synonym: "up-regulation of histone H3-K4 methylation" EXACT [] +synonym: "upregulation of histone H3-K4 methylation" EXACT [] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:0051569 ! regulation of histone H3-K4 methylation +relationship: positively_regulates GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0051572 +name: negative regulation of histone H3-K4 methylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] +synonym: "down regulation of histone H3-K4 methylation" EXACT [] +synonym: "down-regulation of histone H3-K4 methylation" EXACT [] +synonym: "downregulation of histone H3-K4 methylation" EXACT [] +synonym: "inhibition of histone H3-K4 methylation" NARROW [] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:0051569 ! regulation of histone H3-K4 methylation +relationship: negatively_regulates GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0051573 +name: negative regulation of histone H3-K9 methylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] +synonym: "down regulation of histone H3-K9 methylation" EXACT [] +synonym: "down-regulation of histone H3-K9 methylation" EXACT [] +synonym: "downregulation of histone H3-K9 methylation" EXACT [] +synonym: "inhibition of histone H3-K9 methylation" NARROW [] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:0051570 ! regulation of histone H3-K9 methylation +relationship: negatively_regulates GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0051574 +name: positive regulation of histone H3-K9 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] +synonym: "activation of histone H3-K9 methylation" NARROW [] +synonym: "stimulation of histone H3-K9 methylation" NARROW [] +synonym: "up regulation of histone H3-K9 methylation" EXACT [] +synonym: "up-regulation of histone H3-K9 methylation" EXACT [] +synonym: "upregulation of histone H3-K9 methylation" EXACT [] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:0051570 ! regulation of histone H3-K9 methylation +relationship: positively_regulates GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0051575 +name: 5'-deoxyribose-5-phosphate lyase activity +namespace: molecular_function +def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966] +synonym: "5'-deoxyribose phosphate activity" EXACT [] +synonym: "dRP lyase activity" BROAD [] +synonym: "dRPase activity" BROAD [] +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0051576 +name: Myf5 binding +namespace: molecular_function +def: "Interacting selectively with the muscle regulatory factor Myf5." [GOC:ai] +is_a: GO:0043426 ! MRF binding + +[Term] +id: GO:0051577 +name: MyoD binding +namespace: molecular_function +def: "Interacting selectively with the muscle regulatory factor MyoD." [GOC:ai] +is_a: GO:0043426 ! MRF binding + +[Term] +id: GO:0051578 +name: Mrf4 binding +namespace: molecular_function +def: "Interacting selectively with the muscle regulatory factor Mrf4." [GOC:ai] +is_a: GO:0043426 ! MRF binding + +[Term] +id: GO:0051579 +name: myogenin binding +namespace: molecular_function +def: "Interacting selectively with the muscle regulatory factor myogenin." [GOC:ai] +is_a: GO:0043426 ! MRF binding + +[Term] +id: GO:0051580 +name: regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of neurotransmitter reuptake" EXACT [] +is_a: GO:0050804 ! regulation of synaptic transmission +is_a: GO:0051588 ! regulation of neurotransmitter transport +relationship: regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051581 +name: negative regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of neurotransmitter uptake" EXACT [] +synonym: "down-regulation of neurotransmitter uptake" EXACT [] +synonym: "downregulation of neurotransmitter uptake" EXACT [] +synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051589 ! negative regulation of neurotransmitter transport +relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051582 +name: positive regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "activation of neurotransmitter uptake" NARROW [] +synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of neurotransmitter uptake" NARROW [] +synonym: "up regulation of neurotransmitter uptake" EXACT [] +synonym: "up-regulation of neurotransmitter uptake" EXACT [] +synonym: "upregulation of neurotransmitter uptake" EXACT [] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051590 ! positive regulation of neurotransmitter transport +relationship: positively_regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051583 +name: dopamine uptake +namespace: biological_process +def: "The directed movement of dopamine into a cell, typically presynaptic neurons or glial cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] +synonym: "dopamine import" EXACT [GOC:dph, GOC:tb] +synonym: "dopamine reuptake" EXACT [] +is_a: GO:0015872 ! dopamine transport +is_a: GO:0051934 ! catecholamine uptake during transmission of nerve impulse +relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0051584 +name: regulation of dopamine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai] +synonym: "regulation of dopamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic +is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse +relationship: regulates GO:0051583 ! dopamine uptake + +[Term] +id: GO:0051585 +name: negative regulation of dopamine uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai] +synonym: "down regulation of dopamine uptake" EXACT [] +synonym: "down-regulation of dopamine uptake" EXACT [] +synonym: "downregulation of dopamine uptake" EXACT [] +synonym: "negative regulation of dopamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051584 ! regulation of dopamine uptake +is_a: GO:0051945 ! negative regulation of catecholamine uptake during transmission of nerve impulse +relationship: negatively_regulates GO:0051583 ! dopamine uptake + +[Term] +id: GO:0051586 +name: positive regulation of dopamine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai] +synonym: "activation of dopamine uptake" NARROW [] +synonym: "positive regulation of dopamine import" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of dopamine uptake" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of dopamine uptake" NARROW [] +synonym: "up regulation of dopamine uptake" EXACT [] +synonym: "up-regulation of dopamine uptake" EXACT [] +synonym: "upregulation of dopamine uptake" EXACT [] +is_a: GO:0051584 ! regulation of dopamine uptake +is_a: GO:0051944 ! positive regulation of catecholamine uptake during transmission of nerve impulse +relationship: positively_regulates GO:0051583 ! dopamine uptake + +[Term] +id: GO:0051587 +name: inhibition of dopamine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai] +synonym: "inhibition of dopamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051585 ! negative regulation of dopamine uptake +is_a: GO:0051609 ! inhibition of neurotransmitter uptake + +[Term] +id: GO:0051588 +name: regulation of neurotransmitter transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells." [GOC:ai] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0051589 +name: negative regulation of neurotransmitter transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells." [GOC:ai] +synonym: "down regulation of neurotransmitter transport" EXACT [] +synonym: "down-regulation of neurotransmitter transport" EXACT [] +synonym: "downregulation of neurotransmitter transport" EXACT [] +synonym: "inhibition of neurotransmitter transport" NARROW [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051588 ! regulation of neurotransmitter transport +relationship: negatively_regulates GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0051590 +name: positive regulation of neurotransmitter transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells." [GOC:ai] +synonym: "activation of neurotransmitter transport" NARROW [] +synonym: "stimulation of neurotransmitter transport" NARROW [] +synonym: "up regulation of neurotransmitter transport" EXACT [] +synonym: "up-regulation of neurotransmitter transport" EXACT [] +synonym: "upregulation of neurotransmitter transport" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051588 ! regulation of neurotransmitter transport +relationship: positively_regulates GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0051591 +name: response to cAMP +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai] +synonym: "response to 3',5' cAMP" EXACT [] +synonym: "response to 3',5'-cAMP" EXACT [] +synonym: "response to adenosine 3',5'-cyclophosphate" EXACT [] +synonym: "response to cyclic AMP" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0051592 +name: response to calcium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai] +synonym: "response to Ca2+ ion" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0051593 +name: response to folic acid +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai] +synonym: "response to folate" EXACT [] +synonym: "response to vitamin B9" EXACT [] +is_a: GO:0001101 ! response to acid +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0051594 +name: detection of glucose +namespace: biological_process +def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "glucose detection" EXACT [] +synonym: "glucose perception" RELATED [] +synonym: "glucose sensing" RELATED [] +is_a: GO:0009732 ! detection of hexose stimulus +is_a: GO:0009749 ! response to glucose stimulus + +[Term] +id: GO:0051595 +name: response to methylglyoxal +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus." [GOC:ai] +subset: gosubset_prok +synonym: "response to pyruvaldehyde" EXACT [] +is_a: GO:0009636 ! response to toxin + +[Term] +id: GO:0051596 +name: methylglyoxal catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] +subset: gosubset_prok +synonym: "methylglyoxal breakdown" EXACT [] +synonym: "methylglyoxal catabolism" EXACT [] +synonym: "methylglyoxal degradation" EXACT [] +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0046185 ! aldehyde catabolic process + +[Term] +id: GO:0051597 +name: response to methylmercury +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai] +synonym: "response to CH3-Hg+" EXACT [] +synonym: "response to MeHg+" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0051598 +name: meiotic recombination checkpoint +namespace: biological_process +def: "A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes." [PMID:14718568] +synonym: "pachytene checkpoint" EXACT [] +is_a: GO:0033313 ! meiotic cell cycle checkpoint +is_a: GO:0045835 ! negative regulation of meiosis +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0051599 +name: response to hydrostatic pressure +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [http://en.wikipedia.org/wiki/Hydrostatic_pressure] +synonym: "response to biomechanical stress" BROAD [] +synonym: "response to static fluid pressure" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0051600 +name: regulation of exocyst localization during endocytosis +namespace: biological_process +def: "Any process that modulates the localization of exocysts during endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse." [GOC:ai] +synonym: "regulation of site selection of endocytosis" RELATED [] +synonym: "relocation of endocytosis" RELATED [] +synonym: "spatial regulation of endocytosis" RELATED [] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0060178 ! regulation of exocyst localization + +[Term] +id: GO:0051601 +name: exocyst localization +namespace: biological_process +def: "Any process by which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse." [GOC:ai] +synonym: "establishment and maintenance of exocyst localization" EXACT [] +is_a: GO:0034629 ! cellular protein complex localization + +[Term] +id: GO:0051602 +name: response to electrical stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai] +synonym: "response to electricity" RELATED [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0051603 +name: proteolysis involved in cellular protein catabolic process +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein during the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai] +subset: gosubset_prok +synonym: "peptidolysis during cellular protein catabolic process" EXACT [] +synonym: "peptidolysis during cellular protein catabolism" EXACT [] +synonym: "peptidolysis involved in cellular protein catabolic process" EXACT [] +synonym: "peptidolysis involved in cellular protein catabolism" EXACT [] +synonym: "proteolysis during cellular protein catabolic process" EXACT [] +synonym: "proteolysis during cellular protein catabolism" EXACT [] +is_a: GO:0006508 ! proteolysis +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0051604 +name: protein maturation +namespace: biological_process +def: "The process leading to the attainment of the full functional capacity of a protein." [GOC:ai] +subset: goslim_pir +is_a: GO:0019538 ! protein metabolic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0051605 +name: protein maturation via proteolysis +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein during protein maturation, the process leading to the attainment of the full functional capacity of a protein." [GOC:ai] +synonym: "peptidolysis during protein maturation" EXACT [] +is_a: GO:0006508 ! proteolysis +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0051606 +name: detection of stimulus +namespace: biological_process +def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] +subset: goslim_pir +subset: gosubset_prok +synonym: "perception of stimulus" RELATED [] +synonym: "stimulus detection" EXACT [] +synonym: "stimulus sensing" RELATED [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0051607 +name: defense response to virus +namespace: biological_process +def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] +synonym: "antiviral response" EXACT [] +synonym: "defence response to virus" EXACT [] +synonym: "defense response to viruses" EXACT [] +is_a: GO:0002252 ! immune effector process +is_a: GO:0006952 ! defense response +is_a: GO:0009615 ! response to virus + +[Term] +id: GO:0051608 +name: histamine transport +namespace: biological_process +def: "The directed movement of histamine into, out of, within or between cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0051609 +name: inhibition of neurotransmitter uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai] +synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake + +[Term] +id: GO:0051610 +name: serotonin uptake +namespace: biological_process +def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] +synonym: "5-HT uptake" EXACT [] +synonym: "5-hydroxytryptamine uptake" EXACT [] +synonym: "5HT uptake" EXACT [] +synonym: "serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0006837 ! serotonin transport + +[Term] +id: GO:0051611 +name: regulation of serotonin uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai] +synonym: "regulation of 5-HT uptake" EXACT [] +synonym: "regulation of 5-hydroxytryptamine uptake" EXACT [] +synonym: "regulation of 5HT uptake" EXACT [] +synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +relationship: regulates GO:0051610 ! serotonin uptake + +[Term] +id: GO:0051612 +name: negative regulation of serotonin uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] +synonym: "down regulation of serotonin uptake" EXACT [] +synonym: "down-regulation of serotonin uptake" EXACT [] +synonym: "downregulation of serotonin uptake" EXACT [] +synonym: "negative regulation of 5-HT uptake" EXACT [] +synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT [] +synonym: "negative regulation of 5HT uptake" EXACT [] +synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051611 ! regulation of serotonin uptake +relationship: negatively_regulates GO:0051610 ! serotonin uptake + +[Term] +id: GO:0051613 +name: positive regulation of serotonin uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] +synonym: "activation of serotonin uptake" NARROW [] +synonym: "positive regulation of 5-HT uptake" EXACT [] +synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT [] +synonym: "positive regulation of 5HT uptake" EXACT [] +synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of serotonin uptake" NARROW [] +synonym: "up regulation of serotonin uptake" EXACT [] +synonym: "up-regulation of serotonin uptake" EXACT [] +synonym: "upregulation of serotonin uptake" EXACT [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051611 ! regulation of serotonin uptake +relationship: positively_regulates GO:0051610 ! serotonin uptake + +[Term] +id: GO:0051614 +name: inhibition of serotonin uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai] +synonym: "inhibition of 5-HT uptake" EXACT [] +synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT [] +synonym: "inhibition of 5HT uptake" EXACT [] +synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051612 ! negative regulation of serotonin uptake + +[Term] +id: GO:0051615 +name: histamine uptake +namespace: biological_process +def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +synonym: "histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0051608 ! histamine transport + +[Term] +id: GO:0051616 +name: regulation of histamine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai] +synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051617 +name: negative regulation of histamine uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] +synonym: "down regulation of histamine uptake" EXACT [] +synonym: "down-regulation of histamine uptake" EXACT [] +synonym: "downregulation of histamine uptake" EXACT [] +synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051616 ! regulation of histamine uptake +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051618 +name: positive regulation of histamine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] +synonym: "activation of histamine uptake" NARROW [] +synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of histamine uptake" NARROW [] +synonym: "up regulation of histamine uptake" EXACT [] +synonym: "up-regulation of histamine uptake" EXACT [] +synonym: "upregulation of histamine uptake" EXACT [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051616 ! regulation of histamine uptake +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051619 +name: inhibition of histamine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai] +synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051617 ! negative regulation of histamine uptake + +[Term] +id: GO:0051620 +name: norepinephrine uptake +namespace: biological_process +def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] +synonym: "levarterenol reuptake" EXACT [] +synonym: "levarterenol uptake" EXACT [] +synonym: "noradrenaline reuptake" EXACT [] +synonym: "noradrenaline uptake" EXACT [] +synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "norepinephrine reuptake" EXACT [] +is_a: GO:0015874 ! norepinephrine transport +is_a: GO:0051934 ! catecholamine uptake during transmission of nerve impulse + +[Term] +id: GO:0051621 +name: regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] +synonym: "regulation of levarterenol uptake" EXACT [] +synonym: "regulation of noradrenaline uptake" EXACT [] +synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse +relationship: regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051622 +name: negative regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "down regulation of norepinephrine uptake" EXACT [] +synonym: "down-regulation of norepinephrine uptake" EXACT [] +synonym: "downregulation of norepinephrine uptake" EXACT [] +synonym: "negative regulation of levarterenol uptake" EXACT [] +synonym: "negative regulation of noradrenaline uptake" EXACT [] +synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051621 ! regulation of norepinephrine uptake +is_a: GO:0051945 ! negative regulation of catecholamine uptake during transmission of nerve impulse +relationship: negatively_regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051623 +name: positive regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "activation of norepinephrine uptake" NARROW [] +synonym: "positive regulation of levarterenol uptake" EXACT [] +synonym: "positive regulation of noradrenaline uptake" EXACT [] +synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of norepinephrine uptake" NARROW [] +synonym: "up regulation of norepinephrine uptake" EXACT [] +synonym: "up-regulation of norepinephrine uptake" EXACT [] +synonym: "upregulation of norepinephrine uptake" EXACT [] +is_a: GO:0051621 ! regulation of norepinephrine uptake +is_a: GO:0051944 ! positive regulation of catecholamine uptake during transmission of nerve impulse +relationship: positively_regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051624 +name: inhibition of norepinephrine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "inhibition of levarterenol uptake" EXACT [] +synonym: "inhibition of noradrenaline uptake" EXACT [] +synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051622 ! negative regulation of norepinephrine uptake + +[Term] +id: GO:0051625 +name: epinephrine uptake +namespace: biological_process +def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] +synonym: "adrenaline reuptake" EXACT [] +synonym: "adrenaline uptake" EXACT [] +synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "epinephrine reuptake" EXACT [] +is_a: GO:0048241 ! epinephrine transport +is_a: GO:0051934 ! catecholamine uptake during transmission of nerve impulse + +[Term] +id: GO:0051626 +name: regulation of epinephrine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai] +synonym: "regulation of adrenaline uptake" EXACT [] +synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse +relationship: regulates GO:0051625 ! epinephrine uptake + +[Term] +id: GO:0051627 +name: negative regulation of epinephrine uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] +synonym: "down regulation of epinephrine uptake" EXACT [] +synonym: "down-regulation of epinephrine uptake" EXACT [] +synonym: "downregulation of epinephrine uptake" EXACT [] +synonym: "negative regulation of adrenaline uptake" EXACT [] +synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051626 ! regulation of epinephrine uptake +is_a: GO:0051945 ! negative regulation of catecholamine uptake during transmission of nerve impulse +relationship: negatively_regulates GO:0051625 ! epinephrine uptake + +[Term] +id: GO:0051628 +name: positive regulation of epinephrine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] +synonym: "activation of epinephrine uptake" NARROW [] +synonym: "positive regulation of adrenaline uptake" EXACT [] +synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of epinephrine uptake" NARROW [] +synonym: "up regulation of epinephrine uptake" EXACT [] +synonym: "up-regulation of epinephrine uptake" EXACT [] +synonym: "upregulation of epinephrine uptake" EXACT [] +is_a: GO:0051626 ! regulation of epinephrine uptake +is_a: GO:0051944 ! positive regulation of catecholamine uptake during transmission of nerve impulse +relationship: positively_regulates GO:0051625 ! epinephrine uptake + +[Term] +id: GO:0051629 +name: inhibition of epinephrine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai] +synonym: "inhibition of adrenaline uptake" EXACT [] +synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051627 ! negative regulation of epinephrine uptake + +[Term] +id: GO:0051630 +name: acetylcholine uptake +namespace: biological_process +def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] +synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0015870 ! acetylcholine transport + +[Term] +id: GO:0051631 +name: regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] +synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051632 +name: negative regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "down regulation of acetylcholine uptake" EXACT [] +synonym: "down-regulation of acetylcholine uptake" EXACT [] +synonym: "downregulation of acetylcholine uptake" EXACT [] +synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051631 ! regulation of acetylcholine uptake +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051633 +name: positive regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "activation of acetylcholine uptake" NARROW [] +synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of acetylcholine uptake" NARROW [] +synonym: "up regulation of acetylcholine uptake" EXACT [] +synonym: "up-regulation of acetylcholine uptake" EXACT [] +synonym: "upregulation of acetylcholine uptake" EXACT [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051631 ! regulation of acetylcholine uptake +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051634 +name: inhibition of acetylcholine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051632 ! negative regulation of acetylcholine uptake + +[Term] +id: GO:0051635 +name: bacterial cell surface binding +namespace: molecular_function +def: "Interacting selectively with any component on the surface of a bacterial cell." [GOC:ai] +subset: gosubset_prok +synonym: "bacterium cell surface binding" EXACT [] +is_a: GO:0008367 ! bacterial binding +is_a: GO:0043498 ! cell surface binding + +[Term] +id: GO:0051636 +name: Gram-negative bacterial cell surface binding +namespace: molecular_function +def: "Interacting selectively with any component on the surface of a Gram-negative bacterial cell." [GOC:ai] +subset: gosubset_prok +synonym: "Gram-negative bacterium cell surface binding" EXACT [] +is_a: GO:0008368 ! Gram-negative bacterial binding +is_a: GO:0051635 ! bacterial cell surface binding + +[Term] +id: GO:0051637 +name: Gram-positive bacterial cell surface binding +namespace: molecular_function +def: "Interacting selectively with any component on the surface of a Gram-positive bacterium." [GOC:ai] +subset: gosubset_prok +synonym: "Gram-positive bacterium cell surface binding" EXACT [] +is_a: GO:0051076 ! Gram-positive bacterial binding +is_a: GO:0051635 ! bacterial cell surface binding + +[Term] +id: GO:0051638 +name: barbed-end actin filament uncapping +namespace: biological_process +def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] +synonym: "barbed end actin filament uncapping" EXACT [] +synonym: "barbed end F-actin uncapping" EXACT [] +synonym: "barbed-end F-actin uncapping" EXACT [] +synonym: "plus end actin filament uncapping" EXACT [] +synonym: "plus end F-actin uncapping" EXACT [] +synonym: "plus-end actin filament uncapping" EXACT [] +synonym: "plus-end F-actin uncapping" EXACT [] +is_a: GO:0051695 ! actin filament uncapping + +[Term] +id: GO:0051639 +name: actin filament network formation +namespace: biological_process +def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai] +synonym: "actin gel biosynthesis" EXACT [] +synonym: "actin gel formation" EXACT [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0051640 +name: organelle localization +namespace: biological_process +def: "Any process by which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] +subset: goslim_pir +synonym: "establishment and maintenance of organelle localization" EXACT [] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0051641 +name: cellular localization +namespace: biological_process +def: "Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "establishment and maintenance of cellular localization" EXACT [] +synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] +synonym: "intracellular localization" NARROW [] +synonym: "localization within cell" NARROW [] +is_a: GO:0009987 ! cellular process +is_a: GO:0051179 ! localization + +[Term] +id: GO:0051642 +name: centrosome localization +namespace: biological_process +def: "Any process by which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of centrosome localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051643 +name: ER localization +namespace: biological_process +def: "Any process by which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of ER localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051644 +name: plastid localization +namespace: biological_process +def: "Any process by which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of plastid localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051645 +name: Golgi localization +namespace: biological_process +def: "Any process by which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of Golgi localization" EXACT [] +synonym: "Golgi apparatus localization" EXACT [] +synonym: "Golgi body localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051646 +name: mitochondrion localization +namespace: biological_process +def: "Any process by which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of mitochondria localization" EXACT [] +synonym: "establishment and maintenance of mitochondrion localization" EXACT [] +synonym: "localization of mitochondria" EXACT [] +synonym: "localization of mitochondrion" EXACT [] +synonym: "mitochondria localization" EXACT [] +synonym: "mitochondrial localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051647 +name: nucleus localization +namespace: biological_process +def: "Any process by which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "cell nucleus localization" EXACT [] +synonym: "establishment and maintenance of nucleus localization" EXACT [] +synonym: "localization of nucleus" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051648 +name: vesicle localization +namespace: biological_process +def: "Any process by which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] +synonym: "cytoplasmic vesicle localization" EXACT [] +synonym: "establishment and maintenance of vesicle localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051649 +name: establishment of localization in cell +namespace: biological_process +def: "The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell." [GOC:ai, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] +synonym: "establishment of intracellular localization" NARROW [] +synonym: "establishment of localization within cell" NARROW [] +synonym: "positioning within cell" NARROW [] +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0051641 ! cellular localization + +[Term] +id: GO:0051650 +name: establishment of vesicle localization +namespace: biological_process +def: "The directed movement of a vesicle to a specific location." [GOC:ai] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051648 ! vesicle localization + +[Term] +id: GO:0051651 +name: maintenance of location in cell +namespace: biological_process +def: "Any process by which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] +subset: gosubset_prok +synonym: "cellular retention" NARROW [] +synonym: "cellular sequestering" NARROW [] +synonym: "cellular storage" NARROW [] +synonym: "intracellular retention" NARROW [] +synonym: "intracellular sequestering" NARROW [] +synonym: "intracellular storage" NARROW [] +synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of intracellular localization" NARROW [] +synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of localization within cell" NARROW [] +synonym: "retention within cell" NARROW [] +synonym: "sequestering within cell" NARROW [] +synonym: "storage within cell" NARROW [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0051641 ! cellular localization + +[Term] +id: GO:0051652 +name: maintenance of chromosome location +namespace: biological_process +def: "Any process by which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0050000 ! chromosome localization + +[Term] +id: GO:0051653 +name: spindle localization +namespace: biological_process +def: "Any process by which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of spindle localization" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051654 +name: establishment of mitochondrion localization +namespace: biological_process +def: "The directed movement of the mitochondrion to a specific location." [GOC:ai] +synonym: "establishment of mitochondria localization" EXACT [] +synonym: "mitochondria positioning" EXACT [] +synonym: "mitochondrial migration" EXACT [] +synonym: "mitochondrion positioning" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051646 ! mitochondrion localization + +[Term] +id: GO:0051655 +name: maintenance of vesicle location +namespace: biological_process +def: "Any process by which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051648 ! vesicle localization + +[Term] +id: GO:0051656 +name: establishment of organelle localization +namespace: biological_process +def: "The directed movement of an organelle to a specific location." [GOC:ai] +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0051640 ! organelle localization + +[Term] +id: GO:0051657 +name: maintenance of organelle location +namespace: biological_process +def: "Any process by which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0051640 ! organelle localization + +[Term] +id: GO:0051658 +name: maintenance of nucleus location +namespace: biological_process +def: "Any process by which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of cell nucleus location" EXACT [] +synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051647 ! nucleus localization + +[Term] +id: GO:0051659 +name: maintenance of mitochondrion location +namespace: biological_process +def: "Any process by which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of mitochondria localization" EXACT [] +synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051646 ! mitochondrion localization + +[Term] +id: GO:0051660 +name: establishment of centrosome localization +namespace: biological_process +def: "The directed movement of the centrosome to a specific location." [GOC:ai] +synonym: "centrosome positioning" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051642 ! centrosome localization + +[Term] +id: GO:0051661 +name: maintenance of centrosome location +namespace: biological_process +def: "Any process by which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051642 ! centrosome localization + +[Term] +id: GO:0051663 +name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0051662 +def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb] +synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT [] +synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus localization" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus localization (sensu Insecta)" EXACT [] +synonym: "oocyte nucleus localization during oocyte axis determination" EXACT [] +synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb] +synonym: "oocyte nucleus localization during oocyte axis determination (sensu Insecta)" EXACT [] +synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051647 ! nucleus localization +relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification + +[Term] +id: GO:0051664 +name: nuclear pore localization +namespace: biological_process +def: "Any process by which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of nuclear pore localization" EXACT [] +is_a: GO:0034629 ! cellular protein complex localization +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0051665 +name: membrane raft localization +namespace: biological_process +def: "Any process by which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198] +synonym: "establishment and maintenance of membrane raft localization" EXACT [] +synonym: "lipid raft localization" EXACT [] +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0051666 +name: actin cortical patch localization +namespace: biological_process +def: "Any process by which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah] +synonym: "establishment and maintenance of actin cortical patch localization" EXACT [] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0051667 +name: establishment of plastid localization +namespace: biological_process +def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051644 ! plastid localization + +[Term] +id: GO:0051668 +name: localization within membrane +namespace: biological_process +def: "Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] +subset: gosubset_prok +synonym: "establishment and maintenance of localization in membrane" EXACT [] +synonym: "establishment and maintenance of position in membrane" EXACT [] +synonym: "localization to membrane" EXACT [] +synonym: "positioning within membrane" NARROW [] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0051669 +name: fructan beta-fructosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80] +synonym: "beta-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.80] +synonym: "exo-beta-D-fructosidase activity" EXACT [] +synonym: "exo-beta-fructosidase activity" EXACT [] +synonym: "fructan b-fructosidase activity" EXACT [] +synonym: "fructan exohydrolase activity" EXACT [] +synonym: "fructanase activity" EXACT [EC:3.2.1.80] +synonym: "polysaccharide beta-fructofuranosidase activity" EXACT [] +xref: EC:3.2.1.80 +xref: MetaCyc:3.2.1.80-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051670 +name: inulinase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7] +synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT [] +synonym: "endo-inulinase activity" EXACT [] +synonym: "exoinulinase activity" EXACT [] +synonym: "indoinulinase activity" EXACT [] +synonym: "inulase activity" EXACT [] +xref: EC:3.2.1.7 +xref: MetaCyc:3.2.1.7-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051671 +name: induction of autolysin activity in another organism +namespace: biological_process +def: "Any process by which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai] +subset: gosubset_prok +synonym: "activation of autolysin activity in another organism" EXACT [] +synonym: "activation of autolysis in other organism" NARROW [] +synonym: "activation of autolytic activity in other organism" NARROW [] +synonym: "induction of autolysis in other organism" NARROW [] +synonym: "induction of autolytic activity in other organism" NARROW [] +synonym: "positive regulation of autolysin activity in another organism" BROAD [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0043946 ! positive regulation of catalytic activity in other organism during symbiotic interaction + +[Term] +id: GO:0051672 +name: cell wall peptidoglycan catabolic process in another organism +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai] +subset: gosubset_prok +synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT [] +synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT [] +synonym: "cell wall catabolic process in other organism" NARROW [] +synonym: "cell wall catabolism in other organism" NARROW [] +is_a: GO:0009253 ! peptidoglycan catabolic process +is_a: GO:0016998 ! cell wall catabolic process +relationship: part_of GO:0009617 ! response to bacterium + +[Term] +id: GO:0051673 +name: membrane disruption in another organism +namespace: biological_process +def: "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism." [GOC:ai] +subset: gosubset_prok +synonym: "cytolysis, by membrane disruption, in other organism" NARROW [] +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0051674 +name: localization of cell +namespace: biological_process +def: "Any process by which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] +subset: gosubset_prok +synonym: "cell localization" EXACT [] +synonym: "establishment and maintenance of cell localization" EXACT [] +synonym: "establishment and maintenance of localization of cell" EXACT [] +is_a: GO:0051179 ! localization + +[Term] +id: GO:0051675 +name: isopullulanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57] +synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT [] +xref: EC:3.2.1.57 +xref: MetaCyc:3.2.1.57-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051676 +name: pullulan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381] +synonym: "pullulan metabolism" EXACT [] +is_a: GO:0006073 ! glucan metabolic process + +[Term] +id: GO:0051677 +name: pullulan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0051676 ! pullulan metabolic process + +[Term] +id: GO:0051678 +name: pullulan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0051676 ! pullulan metabolic process + +[Term] +id: GO:0051679 +name: 6-alpha-maltosylglucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem:439991] +synonym: "6-alpha-maltosylglucose metabolism" EXACT [] +synonym: "isopanose metabolic process" EXACT [] +synonym: "isopanose metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0051680 +name: 6-alpha-maltosylglucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] +synonym: "isopanose biosynthesis" EXACT [] +synonym: "isopanose biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process + +[Term] +id: GO:0051681 +name: 6-alpha-maltosylglucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] +synonym: "isopanose catabolic process" EXACT [] +synonym: "isopanose catabolism" EXACT [] +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process + +[Term] +id: GO:0051682 +name: galactomannan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0051069 ! galactomannan metabolic process + +[Term] +id: GO:0051683 +name: establishment of Golgi localization +namespace: biological_process +def: "The directed movement of the Golgi to a specific location." [GOC:ai] +synonym: "establishment of Golgi apparatus localization" EXACT [] +synonym: "establishment of Golgi body localization" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051645 ! Golgi localization + +[Term] +id: GO:0051684 +name: maintenance of Golgi location +namespace: biological_process +def: "Any process by which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of Golgi apparatus localization" EXACT [] +synonym: "maintenance of Golgi body localization" EXACT [] +synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051645 ! Golgi localization + +[Term] +id: GO:0051685 +name: maintenance of ER location +namespace: biological_process +def: "Any process by which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of endoplasmic reticulum localization" EXACT [] +synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051643 ! ER localization + +[Term] +id: GO:0051686 +name: establishment of ER localization +namespace: biological_process +def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai] +synonym: "establishment of endoplasmic reticulum localization" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0051643 ! ER localization + +[Term] +id: GO:0051687 +name: maintenance of spindle location +namespace: biological_process +def: "Any process by which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051653 ! spindle localization + +[Term] +id: GO:0051688 +name: maintenance of plastid location +namespace: biological_process +def: "Any process by which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051657 ! maintenance of organelle location +relationship: part_of GO:0051644 ! plastid localization + +[Term] +id: GO:0051689 +name: multicellular organismal oligosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai] +synonym: "organismal oligosaccharide breakdown" EXACT [] +synonym: "organismal oligosaccharide catabolism" EXACT [] +synonym: "organismal oligosaccharide degradation" EXACT [] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0044276 ! multicellular organismal carbohydrate catabolic process +is_a: GO:0051690 ! multicellular organismal oligosaccharide metabolic process + +[Term] +id: GO:0051690 +name: multicellular organismal oligosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai] +synonym: "organismal oligosaccharide metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process + +[Term] +id: GO:0051691 +name: cellular oligosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] +synonym: "cellular oligosaccharide metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0051692 +name: cellular oligosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] +synonym: "cellular oligosaccharide breakdown" EXACT [] +synonym: "cellular oligosaccharide catabolism" EXACT [] +synonym: "cellular oligosaccharide degradation" EXACT [] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0051691 ! cellular oligosaccharide metabolic process + +[Term] +id: GO:0051693 +name: actin filament capping +namespace: biological_process +def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] +synonym: "actin capping activity" RELATED [] +synonym: "F-actin capping activity" RELATED [] +is_a: GO:0030835 ! negative regulation of actin filament depolymerization + +[Term] +id: GO:0051694 +name: pointed-end actin filament capping +namespace: biological_process +def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] +synonym: "minus-end actin filament capping activity" EXACT [] +synonym: "minus-end F-actin capping activity" EXACT [] +synonym: "pointed-end actin capping activity" EXACT [] +synonym: "pointed-end F-actin capping activity" EXACT [] +is_a: GO:0051693 ! actin filament capping + +[Term] +id: GO:0051695 +name: actin filament uncapping +namespace: biological_process +def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] +synonym: "F-actin uncapping" EXACT [] +is_a: GO:0030836 ! positive regulation of actin filament depolymerization + +[Term] +id: GO:0051696 +name: pointed-end actin filament uncapping +namespace: biological_process +def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] +synonym: "minus end actin filament uncapping" EXACT [] +synonym: "minus end F-actin uncapping" EXACT [] +synonym: "minus-end actin filament uncapping" EXACT [] +synonym: "minus-end F-actin uncapping" EXACT [] +synonym: "pointed end actin filament uncapping" EXACT [] +synonym: "pointed end F-actin uncapping" EXACT [] +synonym: "pointed-end F-actin uncapping" EXACT [] +is_a: GO:0051695 ! actin filament uncapping + +[Term] +id: GO:0051697 +name: protein delipidation +namespace: biological_process +def: "The breakage of covalent or non-covalent bonds to detach lipid moieties from a protein." [GOC:ai] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0051698 +name: saccharopine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628] +synonym: "SAX activity" BROAD [] +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0051699 +name: proline oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821] +xref: EC:1.5.3.- +xref: MetaCyc:RXN-821 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0051700 +name: fructosyl-amino acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628] +synonym: "FAOD activity" EXACT [] +xref: EC:1.5.3.- +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0051701 +name: interaction with host +namespace: biological_process +def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051702 +name: interaction with symbiont +namespace: biological_process +def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051703 +name: intraspecies interaction between organisms +namespace: biological_process +def: "Any process by which an organism has an effect on an organism of the same species." [GOC:ai] +subset: goslim_pir +subset: gosubset_prok +synonym: "intraspecies interaction with other organisms" EXACT [] +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0051704 +name: multi-organism process +namespace: biological_process +alt_id: GO:0051706 +def: "Any process by which an organism has an effect on another organism of the same or different species." [GOC:ai] +subset: goslim_goa +subset: goslim_pir +subset: gosubset_prok +synonym: "interaction between organisms" EXACT [] +synonym: "physiological interaction between organisms" EXACT [] +synonym: "physiological interaction with other organism" EXACT [] +is_a: GO:0008150 ! biological_process +disjoint_from: GO:0009987 ! cellular process +disjoint_from: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051705 +name: behavioral interaction between organisms +namespace: biological_process +def: "Any process by which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai] +subset: goslim_pir +synonym: "behavioral interaction with other organism" EXACT [] +synonym: "behavioural interaction between organisms" EXACT [] +synonym: "behavioural interaction with other organism" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0051707 +name: response to other organism +namespace: biological_process +alt_id: GO:0009613 +alt_id: GO:0042828 +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] +subset: gosubset_prok +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0051704 ! multi-organism process + +[Term] +id: GO:0051708 +name: intracellular protein transport in other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of an organism's proteins within a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051709 +name: regulation of killing of cells of another organism +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] +subset: gosubset_prok +is_a: GO:0031341 ! regulation of cell killing +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051710 +name: regulation of cytolysis of cells of another organism +namespace: biological_process +alt_id: GO:0001902 +def: "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] +subset: gosubset_prok +synonym: "regulation of cytolysis of cells of another, non-host, organism" NARROW [] +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: regulates GO:0051715 ! cytolysis of cells of another organism + +[Term] +id: GO:0051711 +name: negative regulation of killing of cells of another organism +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of killing of cells of another organism" EXACT [] +synonym: "down-regulation of killing of cells of another organism" EXACT [] +synonym: "downregulation of killing of cells of another organism" EXACT [] +synonym: "inhibition of killing of cells of another organism" NARROW [] +is_a: GO:0031342 ! negative regulation of cell killing +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: negatively_regulates GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051712 +name: positive regulation of killing of cells of another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] +subset: gosubset_prok +synonym: "activation of killing of cells of another organism" NARROW [] +synonym: "stimulation of killing of cells of another organism" NARROW [] +synonym: "up regulation of killing of cells of another organism" EXACT [] +synonym: "up-regulation of killing of cells of another organism" EXACT [] +synonym: "upregulation of killing of cells of another organism" EXACT [] +is_a: GO:0031343 ! positive regulation of cell killing +is_a: GO:0043902 ! positive regulation of multi-organism process +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: positively_regulates GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051713 +name: negative regulation of cytolysis of cells of another organism +namespace: biological_process +alt_id: GO:0001903 +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of cytolysis of cells of another organism" EXACT [] +synonym: "down-regulation of cytolysis of cells of another organism" EXACT [] +synonym: "downregulation of cytolysis of cells of another organism" EXACT [] +synonym: "inhibition of cytolysis of cells of another organism" NARROW [] +synonym: "negative regulation of cytolysis of cells of another, non-host, organism" NARROW [] +is_a: GO:0051710 ! regulation of cytolysis of cells of another organism +is_a: GO:0051711 ! negative regulation of killing of cells of another organism +relationship: negatively_regulates GO:0051715 ! cytolysis of cells of another organism + +[Term] +id: GO:0051714 +name: positive regulation of cytolysis of cells of another organism +namespace: biological_process +alt_id: GO:0001904 +def: "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] +subset: gosubset_prok +synonym: "activation of cytolysis of cells of another organism" NARROW [] +synonym: "positive regulation of cytolysis of cells of another, non-host, organism" NARROW [] +synonym: "stimulation of cytolysis of cells of another organism" NARROW [] +synonym: "up regulation of cytolysis of cells of another organism" EXACT [] +synonym: "up-regulation of cytolysis of cells of another organism" EXACT [] +synonym: "upregulation of cytolysis of cells of another organism" EXACT [] +is_a: GO:0051710 ! regulation of cytolysis of cells of another organism +is_a: GO:0051712 ! positive regulation of killing of cells of another organism +relationship: positively_regulates GO:0051715 ! cytolysis of cells of another organism + +[Term] +id: GO:0051715 +name: cytolysis of cells of another organism +namespace: biological_process +alt_id: GO:0001901 +def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai] +subset: gosubset_prok +synonym: "cytolysis of cells of another, non-host, organism" NARROW [] +synonym: "cytolysis of cells of competing organism" NARROW [] +is_a: GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051716 +name: cellular response to stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jl] +subset: gosubset_prok +is_a: GO:0009987 ! cellular process +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0051717 +name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN] +synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" EXACT [EC:2.7.1.-] +synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" EXACT [EC:2.7.1.-] +synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" EXACT [EC:2.7.1.-] +xref: MetaCyc:3.1.3.62-RXN +is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity + +[Term] +id: GO:0051718 +name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpG." [EC:2.1.1.37, PMID:15689527] +synonym: "HpaII methylase" NARROW [EC:2.1.1.37] +synonym: "HpaII' methylase" NARROW [EC:2.1.1.37] +synonym: "M.BsuRIa" NARROW [EC:2.1.1.37] +synonym: "M.BsuRIb" NARROW [EC:2.1.1.37] +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity + +[Term] +id: GO:0051719 +name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527] +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity + +[Term] +id: GO:0051720 +name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527] +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity + +[Term] +id: GO:0051721 +name: protein phosphatase 2A binding +namespace: molecular_function +def: "Interacting selectively with the enzyme protein phosphatase 2A." [GOC:ai] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:0051722 +name: protein C-terminal methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216] +synonym: "protein phosphatase methylesterase activity" NARROW [] +is_a: GO:0051723 ! protein methylesterase activity + +[Term] +id: GO:0051723 +name: protein methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai] +subset: gosubset_prok +synonym: "PME activity" EXACT [EC:2.7.1.-] +synonym: "protein carboxyl methylesterase activity" EXACT [EC:2.7.1.-] +synonym: "protein carboxylic ester hydrolase activity" EXACT [] +synonym: "protein methyl-esterase activity" EXACT [EC:2.7.1.-] +is_a: GO:0004091 ! carboxylesterase activity + +[Term] +id: GO:0051724 +name: NAD transporter activity +namespace: molecular_function +def: "Enables the directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai] +synonym: "NAD (oxidized) transporter activity" EXACT [] +synonym: "NAD (reduced) transporter activity" EXACT [] +synonym: "NAD+ transporter activity" EXACT [] +synonym: "NADH transporter activity" EXACT [] +synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] +synonym: "oxidized NAD transporter activity" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] +synonym: "reduced NAD transporter activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0051184 ! cofactor transporter activity + +[Term] +id: GO:0051725 +name: protein amino acid de-ADP-ribosylation +namespace: biological_process +def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai] +synonym: "poly(ADP-ribose) removal from protein" EXACT [] +synonym: "protein poly(ADP-ribose) catabolic process" EXACT [] +synonym: "protein poly(ADP-ribose) catabolism" EXACT [] +synonym: "protein poly(ADP-ribose) degradation" EXACT [] +synonym: "protein poly(ADP-ribose) hydrolysis" EXACT [] +synonym: "removal of ADP-ribose from protein" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0051726 +name: regulation of cell cycle +namespace: biological_process +alt_id: GO:0000074 +def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] +subset: gosubset_prok +synonym: "cell cycle control" EXACT [] +synonym: "cell cycle modulation" EXACT [] +synonym: "cell cycle regulation" EXACT [] +synonym: "cell cycle regulator" RELATED [] +synonym: "control of cell cycle progression" EXACT [] +synonym: "modulation of cell cycle progression" EXACT [] +synonym: "regulation of cell cycle progression" EXACT [] +synonym: "regulation of progression through cell cycle" EXACT [] +synonym: "tumor suppressor" RELATED [] +xref: Reactome:156678 +xref: Reactome:156699 +xref: Reactome:156711 +xref: Reactome:162657 +xref: Reactome:204139 +xref: Reactome:209045 +xref: Reactome:209050 +xref: Reactome:211608 +xref: Reactome:213123 +xref: Reactome:218715 +xref: Reactome:218726 +xref: Reactome:221382 +xref: Reactome:222877 +xref: Reactome:227596 +xref: Reactome:230018 +xref: Reactome:235842 +xref: Reactome:235853 +xref: Reactome:238231 +xref: Reactome:239383 +xref: Reactome:243028 +xref: Reactome:243033 +xref: Reactome:244651 +xref: Reactome:245640 +xref: Reactome:248176 +xref: Reactome:248181 +xref: Reactome:249585 +xref: Reactome:250281 +xref: Reactome:251600 +xref: Reactome:252387 +xref: Reactome:253031 +xref: Reactome:254679 +xref: Reactome:255542 +xref: Reactome:256281 +xref: Reactome:257921 +xref: Reactome:258917 +xref: Reactome:259656 +xref: Reactome:261512 +xref: Reactome:262291 +xref: Reactome:264389 +xref: Reactome:265239 +xref: Reactome:267430 +xref: Reactome:267435 +xref: Reactome:268364 +xref: Reactome:280849 +xref: Reactome:282764 +xref: Reactome:285431 +xref: Reactome:285436 +xref: Reactome:286566 +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007049 ! cell cycle + +[Term] +id: GO:0051727 +name: cell cycle switching, meiotic to mitotic cell cycle +namespace: biological_process +def: "The process by which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai] +synonym: "cell cycle switching, meiosis to mitosis" NARROW [] +synonym: "conversion to mitosis" NARROW [] +synonym: "conversion to mitotic cell cycle" EXACT [] +synonym: "entry into mitosis" NARROW [] +synonym: "entry into mitotic cell cycle" EXACT [] +synonym: "initiation of mitosis" NARROW [] +synonym: "initiation of mitotic cell cycle" EXACT [] +synonym: "mitotic entry" NARROW [] +is_a: GO:0060184 ! cell cycle switching + +[Term] +id: GO:0051728 +name: cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +alt_id: GO:0042061 +def: "The process by which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] +synonym: "cell cycle switching, mitotis to meiosis" NARROW [] +synonym: "conversion to meiosis" NARROW [] +synonym: "conversion to meiotic cell cycle" EXACT [] +synonym: "entry into meiosis" NARROW [] +synonym: "entry into meiotic cell cycle" EXACT [] +synonym: "initiation of meiosis" NARROW [] +synonym: "initiation of meiotic cell cycle" EXACT [] +synonym: "meiotic entry" NARROW [] +is_a: GO:0060184 ! cell cycle switching + +[Term] +id: GO:0051729 +name: germline cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +def: "The process by which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] +synonym: "germline cell cycle switching, mitotis to meiosis" NARROW [] +synonym: "germline conversion to meiosis" NARROW [] +synonym: "germline conversion to meiotic cell cycle" EXACT [] +synonym: "germline entry into meiosis" NARROW [] +synonym: "germline entry into meiotic cell cycle" EXACT [] +synonym: "germline initiation of meiosis" NARROW [] +synonym: "germline initiation of meiotic cell cycle" EXACT [] +synonym: "germline meiotic entry" NARROW [] +is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle + +[Term] +id: GO:0051730 +name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918] +synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT [] +synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "GTP-dependent RNA kinase activity" EXACT [] +synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051732 ! polyribonucleotide kinase activity +is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity + +[Term] +id: GO:0051731 +name: polynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] +synonym: "5'-dephosphopolynucleotide kinase activity" EXACT [] +synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [EC:2.7.1.78] +synonym: "PNK" RELATED [EC:2.7.1.78] +synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [EC:2.7.1.78] +synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [EC:2.7.1.78] +synonym: "polynucleotide 5'-hydroxyl-kinase activity" EXACT [EC:2.7.1.78] +xref: EC:2.7.1.- +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity + +[Term] +id: GO:0051732 +name: polyribonucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [EC:2.7.1.78] +synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [EC:2.7.1.78] +synonym: "5'-hydroxyl RNA kinase activity" EXACT [EC:2.7.1.78] +synonym: "RNA 5'-hydroxyl kinase activity" EXACT [] +synonym: "RNA kinase activity" EXACT [] +is_a: GO:0051731 ! polynucleotide kinase activity + +[Term] +id: GO:0051733 +name: polydeoxyribonucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [EC:2.7.1.78] +synonym: "DNA 5'-hydroxyl kinase activity" EXACT [] +synonym: "DNA kinase activity" EXACT [] +is_a: GO:0051731 ! polynucleotide kinase activity + +[Term] +id: GO:0051734 +name: ATP-dependent polynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] +synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] +synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78] +synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] +xref: EC:2.7.1.- +is_a: GO:0051731 ! polynucleotide kinase activity + +[Term] +id: GO:0051735 +name: GTP-dependent polynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78] +synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] +synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] +xref: EC:2.7.1.- +is_a: GO:0051731 ! polynucleotide kinase activity + +[Term] +id: GO:0051736 +name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78] +synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT [] +synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "ATP-dependent RNA kinase activity" EXACT [] +synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051732 ! polyribonucleotide kinase activity +is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity + +[Term] +id: GO:0051737 +name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918] +synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "GTP-dependent DNA kinase activity" EXACT [] +synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT [] +synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity +is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity + +[Term] +id: GO:0051738 +name: xanthophyll binding +namespace: molecular_function +def: "Interacting selectively with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743] +is_a: GO:0019840 ! isoprenoid binding +is_a: GO:0031409 ! pigment binding + +[Term] +id: GO:0051739 +name: ammonia transporter activity +namespace: molecular_function +def: "Enables the directed movement of ammonia into, out of, within or between cells." [GOC:go_curators] +subset: gosubset_prok +is_a: GO:0022892 ! substrate-specific transporter activity + +[Term] +id: GO:0051740 +name: ethylene binding +namespace: molecular_function +def: "Interacting selectively with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai] +synonym: "ethene binding" EXACT [] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0051741 +name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542] +synonym: "MPBQ methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-2542 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0051742 +name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762] +synonym: "MSBQ methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-2762 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0051743 +name: red chlorophyll catabolite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: red chlorophyll catabolite (RCC) + reduced ferredoxin + 2 H+ = primary fluorescent catabolite (pFCC) + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite to a colorless tetrapyrrole with a strong blue fluorescence." [PMID:10743659] +synonym: "RCC reductase activity" EXACT [] +xref: EC:1.3.7.- +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0051744 +name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72] +xref: MetaCyc:RXN1F-72 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0051745 +name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.1.2] +synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" EXACT [EC:1.17.1.2] +synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT [] +xref: EC:1.17.1.2 +xref: MetaCyc:1.17.1.2-RXN +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0051746 +name: thalianol synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655] +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0051747 +name: DNA demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851] +synonym: "DNA demethylase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0051748 +name: UTP-monosaccharide-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] +subset: gosubset_prok +synonym: "PsUSP" RELATED [EC:2.7.7.64] +synonym: "UDP-monosaccharide diphosphorylase activity" EXACT [] +synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT [] +synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64] +synonym: "USP" RELATED [EC:2.7.7.64] +xref: EC:2.7.7.64 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0051749 +name: indole acetic acid carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896] +synonym: "IAA carboxyl methyltransferase activity" EXACT [] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0051750 +name: delta3,5-delta2,4-dienoyl-CoA isomerase activity +namespace: molecular_function +def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:16040662] +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0051751 +name: alpha-1,4-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,4-linkage." [PMID:15772281] +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0051752 +name: phosphoglucan, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411] +synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.5] +synonym: "OK1" RELATED [EC:2.7.9.5] +synonym: "PWD" RELATED [EC:2.7.9.5] +xref: EC:2.7.9.5 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0051753 +name: mannan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-1,4-linked mannan backbone in substrates such as galactomannan." [PMID:14726589] +synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW [] +synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT [] +is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity + +[Term] +id: GO:0051754 +name: meiotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "The cell cycle process whereby centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576] +synonym: "meiotic sister chromatid cohesion at centromere" EXACT [] +synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0051755 +name: meiotic sister chromatid arm separation +namespace: biological_process +def: "The cell cycle process whereby sister chromatid arms are physically detached from each other during meiosis." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007127 ! meiosis I +relationship: part_of GO:0051757 ! meiotic sister chromatid separation + +[Term] +id: GO:0051756 +name: meiotic sister chromatid centromere separation +namespace: biological_process +def: "The cell cycle process whereby the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] +is_a: GO:0034510 ! centromere separation +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation +relationship: part_of GO:0051757 ! meiotic sister chromatid separation + +[Term] +id: GO:0051757 +name: meiotic sister chromatid separation +namespace: biological_process +def: "The process by which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] +is_a: GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0051758 +name: homologous chromosome movement towards spindle pole during meiosis I +namespace: biological_process +def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I." [GOC:ai] +synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0051759 +name: sister chromosome movement towards spindle pole during meiosis II +namespace: biological_process +def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai] +synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0051760 +name: meiotic sister chromatid cohesion, arms +namespace: biological_process +def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576] +synonym: "meiotic sister chromatid cohesion along arms" EXACT [] +synonym: "sister chromatid cohesion along arms at meiosis I" EXACT [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0051761 +name: sesquiterpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] +subset: gosubset_prok +synonym: "sesquiterpene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0051762 +name: sesquiterpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] +subset: gosubset_prok +is_a: GO:0046246 ! terpene biosynthetic process +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:0051763 +name: sesquiterpene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] +subset: gosubset_prok +is_a: GO:0046247 ! terpene catabolic process +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:0051764 +name: actin crosslink formation +namespace: biological_process +def: "The process by which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai] +comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'. +synonym: "actin bundling" RELATED [] +synonym: "actin crosslinking" EXACT [] +synonym: "bridging actin filaments" NARROW [] +synonym: "formation of actin crosslink" EXACT [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0051765 +name: inositol tetrakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai] +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0051766 +name: inositol trisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai] +is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0051767 +name: nitric-oxide synthase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, GOC:ai] +synonym: "NO synthase biosynthesis" EXACT [] +synonym: "NO synthase biosynthetic process" EXACT [] +synonym: "NOS biosynthesis" EXACT [] +synonym: "NOS biosynthetic process" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0051768 +name: nitric-oxide synthase 2 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nitric-oxide synthase 2, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [GOC:ai] +synonym: "nitric-oxide synthase (type 2) biosynthesis" EXACT [] +synonym: "nitric-oxide synthase (type 2) biosynthetic process" EXACT [] +synonym: "nitric-oxide synthase (type II) biosynthesis" EXACT [] +synonym: "nitric-oxide synthase (type II) biosynthetic process" EXACT [] +synonym: "NOS2 synthase biosynthesis" EXACT [] +synonym: "NOS2 synthase biosynthetic process" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0051769 +name: regulation of nitric-oxide synthase biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase." [GOC:ai] +synonym: "regulation of NO synthase biosynthesis" EXACT [] +synonym: "regulation of NO synthase biosynthetic process" EXACT [] +synonym: "regulation of NOS biosynthesis" EXACT [] +synonym: "regulation of NOS biosynthetic process" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process + +[Term] +id: GO:0051770 +name: positive regulation of nitric-oxide synthase biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase." [GOC:ai] +synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW [] +synonym: "positive regulation of NO synthase biosynthesis" EXACT [] +synonym: "positive regulation of NO synthase biosynthetic process" EXACT [] +synonym: "positive regulation of NOS biosynthesis" EXACT [] +synonym: "positive regulation of NOS biosynthetic process" EXACT [] +synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW [] +synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process +relationship: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process + +[Term] +id: GO:0051771 +name: negative regulation of nitric-oxide synthase biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase." [GOC:ai] +synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW [] +synonym: "negative regulation of NO synthase biosynthesis" EXACT [] +synonym: "negative regulation of NO synthase biosynthetic process" EXACT [] +synonym: "negative regulation of NOS biosynthesis" EXACT [] +synonym: "negative regulation of NOS biosynthetic process" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process +relationship: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process + +[Term] +id: GO:0051772 +name: regulation of nitric-oxide synthase 2 biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2." [GOC:ai] +synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT [] +synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT [] +synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" EXACT [] +synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT [] +synonym: "regulation of NOS2 synthase biosynthesis" EXACT [] +synonym: "regulation of NOS2 synthase biosynthetic process" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process + +[Term] +id: GO:0051773 +name: positive regulation of nitric-oxide synthase 2 biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase 2." [GOC:ai] +synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT [] +synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT [] +synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" EXACT [] +synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT [] +synonym: "positive regulation of NOS2 synthase biosynthesis" EXACT [] +synonym: "positive regulation of NOS2 synthase biosynthetic process" EXACT [] +synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] +synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] +synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0051772 ! regulation of nitric-oxide synthase 2 biosynthetic process +relationship: positively_regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process + +[Term] +id: GO:0051774 +name: negative regulation of nitric-oxide synthase 2 biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2." [GOC:ai] +synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] +synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] +synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" EXACT [] +synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT [] +synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT [] +synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" EXACT [] +synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT [] +synonym: "negative regulation of NOS2 synthase biosynthesis" EXACT [] +synonym: "negative regulation of NOS2 synthase biosynthetic process" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0051772 ! regulation of nitric-oxide synthase 2 biosynthetic process +relationship: negatively_regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process + +[Term] +id: GO:0051775 +name: response to redox state +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] +subset: gosubset_prok +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0051776 +name: detection of redox state +namespace: biological_process +def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] +synonym: "redox sensing" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051775 ! response to redox state + +[Term] +id: GO:0051777 +name: ent-kaurenoate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159] +comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. +synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79] +synonym: "ent-kaurenoic acid oxidase activity" EXACT [] +xref: MetaCyc:RXN1F-159 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0051778 +name: ent-7-alpha-hydroxykaurenoate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160] +comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. +xref: MetaCyc:RXN1F-160 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0051779 +name: gibberellin 12-aldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + O2 = gibberellin 12 (GA12) + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161] +comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. +synonym: "GA12-aldehyde oxidase activity" EXACT [] +xref: MetaCyc:RXN1F-161 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0051780 +name: behavioral response to nutrient +namespace: biological_process +def: "A change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] +synonym: "behavioural response to nutrient" EXACT [] +is_a: GO:0007584 ! response to nutrient + +[Term] +id: GO:0051781 +name: positive regulation of cell division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] +synonym: "activation of cell division" NARROW [] +synonym: "stimulation of cell division" NARROW [] +synonym: "up regulation of cell division" EXACT [] +synonym: "up-regulation of cell division" EXACT [] +synonym: "upregulation of cell division" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051302 ! regulation of cell division +relationship: positively_regulates GO:0051301 ! cell division + +[Term] +id: GO:0051782 +name: negative regulation of cell division +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell division." [GOC:ai] +synonym: "down regulation of cell division" EXACT [] +synonym: "down-regulation of cell division" EXACT [] +synonym: "downregulation of cell division" EXACT [] +synonym: "inhibition of cell division" NARROW [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051302 ! regulation of cell division +relationship: negatively_regulates GO:0051301 ! cell division + +[Term] +id: GO:0051783 +name: regulation of nuclear division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0000280 ! nuclear division + +[Term] +id: GO:0051784 +name: negative regulation of nuclear division +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] +synonym: "down regulation of nuclear division" EXACT [] +synonym: "down-regulation of nuclear division" EXACT [] +synonym: "downregulation of nuclear division" EXACT [] +synonym: "inhibition of nuclear division" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0051783 ! regulation of nuclear division +relationship: negatively_regulates GO:0000280 ! nuclear division + +[Term] +id: GO:0051785 +name: positive regulation of nuclear division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] +synonym: "activation of nuclear division" NARROW [] +synonym: "stimulation of nuclear division" NARROW [] +synonym: "up regulation of nuclear division" EXACT [] +synonym: "up-regulation of nuclear division" EXACT [] +synonym: "upregulation of nuclear division" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0051783 ! regulation of nuclear division +relationship: positively_regulates GO:0000280 ! nuclear division + +[Term] +id: GO:0051786 +name: all-trans-retinol 13,14-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23] +synonym: "(13,14)-all-trans-retinol saturase activity" EXACT [] +synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT [] +synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT [] +synonym: "retinol saturase activity" EXACT [EC:1.3.99.23] +synonym: "RetSat activity" EXACT [EC:1.3.99.23] +xref: EC:1.3.99.23 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0051787 +name: misfolded protein binding +namespace: molecular_function +def: "Interacting selectively with a misfolded protein." [GOC:ai] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051788 +name: response to misfolded protein +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators] +is_a: GO:0006950 ! response to stress +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0051789 ! response to protein stimulus + +[Term] +id: GO:0051789 +name: response to protein stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai] +subset: gosubset_prok +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0051790 +name: short-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than 8 carbons." [GOC:go_curators] +synonym: "short chain fatty acid biosynthesis" EXACT [] +synonym: "short chain fatty acid biosynthetic process" EXACT [] +synonym: "short-chain fatty acid anabolism" EXACT [] +synonym: "short-chain fatty acid biosynthesis" EXACT [] +synonym: "short-chain fatty acid formation" EXACT [] +synonym: "short-chain fatty acid synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0051791 +name: medium-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving medium-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C8-12." [GOC:go_curators] +synonym: "medium chain fatty acid metabolic process" EXACT [] +synonym: "medium chain fatty acid metabolism" EXACT [] +synonym: "medium-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0051792 +name: medium-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] +synonym: "medium chain fatty acid biosynthesis" EXACT [] +synonym: "medium chain fatty acid biosynthetic process" EXACT [] +synonym: "medium-chain fatty acid anabolism" EXACT [] +synonym: "medium-chain fatty acid biosynthesis" EXACT [] +synonym: "medium-chain fatty acid formation" EXACT [] +synonym: "medium-chain fatty acid synthesis" EXACT [] +is_a: GO:0051791 ! medium-chain fatty acid metabolic process + +[Term] +id: GO:0051793 +name: medium-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] +synonym: "medium chain fatty acid catabolic process" EXACT [] +synonym: "medium chain fatty acid catabolism" EXACT [] +synonym: "medium-chain fatty acid breakdown" EXACT [] +synonym: "medium-chain fatty acid catabolism" EXACT [] +synonym: "medium-chain fatty acid degradation" EXACT [] +is_a: GO:0051791 ! medium-chain fatty acid metabolic process + +[Term] +id: GO:0051794 +name: regulation of catagen +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai] +is_a: GO:0048819 ! regulation of hair follicle maturation +relationship: regulates GO:0042637 ! catagen + +[Term] +id: GO:0051795 +name: positive regulation of catagen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai] +synonym: "activation of catagen" NARROW [] +synonym: "stimulation of catagen" NARROW [] +synonym: "up regulation of catagen" EXACT [] +synonym: "up-regulation of catagen" EXACT [] +synonym: "upregulation of catagen" EXACT [] +is_a: GO:0048818 ! positive regulation of hair follicle maturation +is_a: GO:0051794 ! regulation of catagen +relationship: positively_regulates GO:0042637 ! catagen + +[Term] +id: GO:0051796 +name: negative regulation of catagen +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai] +synonym: "down regulation of catagen" EXACT [] +synonym: "down-regulation of catagen" EXACT [] +synonym: "downregulation of catagen" EXACT [] +synonym: "inhibition of catagen" NARROW [] +is_a: GO:0048817 ! negative regulation of hair follicle maturation +is_a: GO:0051794 ! regulation of catagen +relationship: negatively_regulates GO:0042637 ! catagen + +[Term] +id: GO:0051797 +name: regulation of hair follicle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:0045682 ! regulation of epidermis development +relationship: regulates GO:0001942 ! hair follicle development + +[Term] +id: GO:0051798 +name: positive regulation of hair follicle development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai] +synonym: "activation of hair follicle development" NARROW [] +synonym: "stimulation of hair follicle development" NARROW [] +synonym: "up regulation of hair follicle development" EXACT [] +synonym: "up-regulation of hair follicle development" EXACT [] +synonym: "upregulation of hair follicle development" EXACT [] +is_a: GO:0045684 ! positive regulation of epidermis development +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0051797 ! regulation of hair follicle development +relationship: positively_regulates GO:0001942 ! hair follicle development + +[Term] +id: GO:0051799 +name: negative regulation of hair follicle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hair follicle development." [GOC:ai] +synonym: "down regulation of hair follicle development" EXACT [] +synonym: "down-regulation of hair follicle development" EXACT [] +synonym: "downregulation of hair follicle development" EXACT [] +synonym: "inhibition of hair follicle development" NARROW [] +is_a: GO:0045683 ! negative regulation of epidermis development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0051797 ! regulation of hair follicle development +relationship: negatively_regulates GO:0001942 ! hair follicle development + +[Term] +id: GO:0051800 +name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidyl inositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831] +synonym: "PTEN activity" BROAD [] +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0051801 +name: cytolysis of cells in other organism during symbiotic interaction +namespace: biological_process +def: "The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0051715 ! cytolysis of cells of another organism +is_a: GO:0051883 ! killing of cells in other organism during symbiotic interaction + +[Term] +id: GO:0051802 +name: regulation of cytolysis of cells in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism +is_a: GO:0051710 ! regulation of cytolysis of cells of another organism +relationship: regulates GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction + +[Term] +id: GO:0051803 +name: negative regulation of cytolysis of cells in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW [] +is_a: GO:0051713 ! negative regulation of cytolysis of cells of another organism +is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction +relationship: negatively_regulates GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction + +[Term] +id: GO:0051804 +name: positive regulation of cytolysis of cells in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +is_a: GO:0051714 ! positive regulation of cytolysis of cells of another organism +is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction +relationship: positively_regulates GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction + +[Term] +id: GO:0051805 +name: evasion or tolerance of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism avoids the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mb] +subset: gosubset_prok +synonym: "immune evasion" EXACT [] +is_a: GO:0051807 ! evasion or tolerance of defense response of other organism during symbiotic interaction +is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction + +[Term] +id: GO:0051806 +name: entry into cell of other organism during symbiotic interaction +namespace: biological_process +def: "The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:njm] +subset: gosubset_prok +synonym: "other organism cell invasion" EXACT [] +is_a: GO:0051828 ! entry into other organism during symbiotic interaction + +[Term] +id: GO:0051807 +name: evasion or tolerance of defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense response; the defense response is mounted by the second organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mah] +subset: gosubset_prok +synonym: "evasion of other organism defence response" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction + +[Term] +id: GO:0051808 +name: translocation of peptides or proteins into other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of peptides or proteins produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction + +[Term] +id: GO:0051809 +name: passive evasion of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism avoids the immune response of a second organism without directly interfering with the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615] +subset: gosubset_prok +synonym: "passive immune evasion" EXACT [] +is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0051810 +name: active evasion of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism avoids the immune response of a second organism which directly affects the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615] +subset: gosubset_prok +synonym: "active immune evasion" EXACT [] +is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0051811 +name: active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism avoids the immune response of a second organism by regulating the second organism's complement system, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] +synonym: "active immune evasion via modulation of complement system of other organism" EXACT [] +synonym: "active immune evasion via regulation of complement system of other organism" EXACT [] +is_a: GO:0051810 ! active evasion of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0051812 +name: active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism avoids the immune response of a second organism by regulating the second organism's cytokine networks, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] +synonym: "active immune evasion via modulation of cytokine network of other organism" EXACT [] +synonym: "active immune evasion via regulation of cytokine network of other organism" EXACT [] +is_a: GO:0051810 ! active evasion of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0051813 +name: active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism avoids the immune response of a second organism by regulating the second organism's antigen processing or presentation pathways, where the two organisms are in a symbiotic interaction." [PMID:12439615] +synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation pathway in other organism during symbiotic interaction" EXACT [] +synonym: "active immune evasion via modulation of antigen processing and presentation in other organism" EXACT [] +synonym: "active immune evasion via modulation of antigen processing/presentation in other organism" EXACT [] +synonym: "active immune evasion via regulation of antigen processing and presentation in other organism" EXACT [] +is_a: GO:0042786 ! active evasion of host immune response via regulation of host antigen processing and presentation + +[Term] +id: GO:0051814 +name: movement within other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0051815 +name: migration within other organism during symbiotic interaction +namespace: biological_process +def: "The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051814 ! movement within other organism during symbiotic interaction + +[Term] +id: GO:0051816 +name: acquisition of nutrients from other organism during symbiotic interaction +namespace: biological_process +def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051817 +name: modification of morphology or physiology of other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" EXACT [] +synonym: "regulation of morphology of other organism" NARROW [] +synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" EXACT [] +synonym: "regulation of physiological process in other organism" NARROW [] +synonym: "regulation of physiology of other organism" NARROW [] +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051818 +name: disruption of cells of other organism during symbiotic interaction +namespace: biological_process +def: "A process by which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0051819 +name: induction of tumor, nodule, or growth in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism causes the formation of an abnormal mass of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0051820 +name: induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism causes the formation in a second organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism during symbiotic interaction + +[Term] +id: GO:0051821 +name: dissemination or transmission of organism from other organism during symbiotic interaction +namespace: biological_process +def: "The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051822 +name: dissemination or transmission of organism from other organism by vector during symbiotic interaction +namespace: biological_process +def: "The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051821 ! dissemination or transmission of organism from other organism during symbiotic interaction + +[Term] +id: GO:0051823 +name: regulation of synapse structural plasticity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123] +synonym: "regulation of synaptic structural plasticity" EXACT [] +is_a: GO:0050807 ! regulation of synapse organization + +[Term] +id: GO:0051824 +name: recognition of other organism during symbiotic interaction +namespace: biological_process +def: "The set of specific processes that allow an organism to detect the presence of a second organism via physical or chemical signals, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051825 +name: adhesion to other organism during symbiotic interaction +namespace: biological_process +def: "The attachment of an organism to a second organism, where the two organisms are in a symbiotic interaction. Adhesion may be via adhesion molecules, general stickiness etc., and may be either direct or indirect." [GOC:cc] +subset: gosubset_prok +is_a: GO:0022610 ! biological adhesion +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051826 +name: negative regulation of synapse structural plasticity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai] +synonym: "down regulation of synapse structural plasticity" EXACT [] +synonym: "down-regulation of synapse structural plasticity" EXACT [] +synonym: "downregulation of synapse structural plasticity" EXACT [] +synonym: "inhibition of synapse structural plasticity" NARROW [] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051823 ! regulation of synapse structural plasticity + +[Term] +id: GO:0051827 +name: growth or development on or near surface of other organism during symbiotic interaction +namespace: biological_process +def: "The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0052171 ! growth or development during symbiotic interaction + +[Term] +id: GO:0051828 +name: entry into other organism during symbiotic interaction +namespace: biological_process +def: "Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "invasion into other organism" EXACT [] +synonym: "invasion of other organism" EXACT [] +synonym: "invasive growth" RELATED [] +synonym: "other organism invasion" EXACT [] +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0051829 +name: entry into other organism through natural portals during symbiotic interaction +namespace: biological_process +def: "Penetration by an organism into a second organism via naturally occurring openings in the second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051828 ! entry into other organism during symbiotic interaction + +[Term] +id: GO:0051830 +name: entry into other organism through barriers of other organism during symbiotic interaction +namespace: biological_process +def: "Penetration by an organism into a second organism via active breaching of physical barriers, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051828 ! entry into other organism during symbiotic interaction + +[Term] +id: GO:0051831 +name: growth or development within other organism during symbiotic interaction +namespace: biological_process +def: "The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc] +subset: gosubset_prok +synonym: "invasive growth" BROAD [] +is_a: GO:0052171 ! growth or development during symbiotic interaction + +[Term] +id: GO:0051832 +name: avoidance of defenses of other organism during symbiotic interaction +namespace: biological_process +def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction + +[Term] +id: GO:0051833 +name: suppression of defenses of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense(s) of a second organism, where the two organisms are in a symbiotic interaction. Suppression occurs by active mechanisms that normally result in the shutting down of pathways in the second organism." [GOC:cc] +subset: gosubset_prok +synonym: "negative regulation of defenses of other organism during symbiotic interaction" EXACT [] +is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction + +[Term] +id: GO:0051834 +name: evasion or tolerance of defenses of other organism during symbiotic interaction +namespace: biological_process +def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. Defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers)." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction + +[Term] +id: GO:0051835 +name: positive regulation of synapse structural plasticity +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai] +synonym: "activation of synapse structural plasticity" NARROW [] +synonym: "stimulation of synapse structural plasticity" NARROW [] +synonym: "up regulation of synapse structural plasticity" EXACT [] +synonym: "up-regulation of synapse structural plasticity" EXACT [] +synonym: "upregulation of synapse structural plasticity" EXACT [] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051823 ! regulation of synapse structural plasticity + +[Term] +id: GO:0051836 +name: translocation of molecules into other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a molecule(s) produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "transport of molecules into other organism during symbiotic interaction" EXACT [] +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0051837 +name: translocation of DNA into other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of DNA from an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction + +[Term] +id: GO:0051838 +name: cytolysis by host of symbiont cells +namespace: biological_process +def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction +is_a: GO:0051873 ! killing by host of symbiont cells +is_a: GO:0052337 ! modification by host of symbiont cell membrane + +[Term] +id: GO:0051839 +name: regulation by host of cytolysis of symbiont cells +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction +relationship: part_of GO:0051838 ! cytolysis by host of symbiont cells + +[Term] +id: GO:0051840 +name: negative regulation by host of cytolysis of symbiont cells +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +synonym: "down regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "downregulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "inhibition by host of cytolysis of symbiont cells" NARROW [] +is_a: GO:0051803 ! negative regulation of cytolysis of cells in other organism during symbiotic interaction +is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells + +[Term] +id: GO:0051841 +name: positive regulation by host of cytolysis of symbiont cells +namespace: biological_process +def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +synonym: "activation by host of cytolysis of symbiont cells" NARROW [] +synonym: "stimulation by host of cytolysis of symbiont cells" NARROW [] +synonym: "up regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "upregulation by host of cytolysis of symbiont cells" EXACT [] +is_a: GO:0051804 ! positive regulation of cytolysis of cells in other organism during symbiotic interaction +is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells + +[Term] +id: GO:0051842 +name: evasion or tolerance of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb] +comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. +synonym: "immune evasion" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051843 +name: evasion or tolerance of symbiont defense response +namespace: biological_process +def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "evasion of symbiont defence response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051844 +name: translocation of peptides or proteins into symbiont +namespace: biological_process +def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051808 ! translocation of peptides or proteins into other organism during symbiotic interaction +is_a: GO:0051862 ! translocation of molecules into symbiont + +[Term] +id: GO:0051845 +name: passive evasion of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "passive immune evasion" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051846 +name: active evasion of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active immune evasion" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051847 +name: active evasion of symbiont immune response via regulation of symbiont complement system +namespace: biological_process +def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active immune evasion via modulation of symbiont complement system" EXACT [] +synonym: "active immune evasion via regulation of symbiont complement system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051848 +name: active evasion of symbiont immune response via regulation of symbiont cytokine network +namespace: biological_process +def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT [] +synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051849 +name: active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation +namespace: biological_process +def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT [] +synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT [] +synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT [] +synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051850 +name: acquisition of nutrients from symbiont +namespace: biological_process +def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction + +[Term] +id: GO:0051851 +name: modification by host of symbiont morphology or physiology +namespace: biological_process +def: "The process by which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0051852 +name: disruption by host of symbiont cells +namespace: biological_process +def: "Any process by which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051818 ! disruption of cells of other organism during symbiotic interaction +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology + +[Term] +id: GO:0051853 +name: induction in symbiont of tumor, nodule, or growth +namespace: biological_process +def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +is_obsolete: true + +[Term] +id: GO:0051854 +name: induction in symbiont of tumor, nodule, or growth containing transformed cells +namespace: biological_process +def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +is_obsolete: true + +[Term] +id: GO:0051855 +name: recognition of symbiont +namespace: biological_process +def: "The set of specific processes that allow an organism to detect the presence of its symbiont via physical or chemical signals. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051824 ! recognition of other organism during symbiotic interaction + +[Term] +id: GO:0051856 +name: adhesion to symbiont +namespace: biological_process +def: "The attachment of an organism to its symbiont via adhesion molecules, general stickiness etc., either directly or indirectly. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051825 ! adhesion to other organism during symbiotic interaction + +[Term] +id: GO:0051857 +name: growth or development of organism on or near symbiont surface +namespace: biological_process +def: "The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "growth or development of organism during interaction with symbiont" EXACT [] +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051827 ! growth or development on or near surface of other organism during symbiotic interaction + +[Term] +id: GO:0051858 +name: avoidance of symbiont defenses +namespace: biological_process +def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction +is_a: GO:0052201 ! response to symbiont defenses + +[Term] +id: GO:0051859 +name: suppression of symbiont defenses +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051833 ! suppression of defenses of other organism during symbiotic interaction +is_a: GO:0051858 ! avoidance of symbiont defenses + +[Term] +id: GO:0051860 +name: evasion or tolerance of symbiont defenses +namespace: biological_process +def: "The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction +is_a: GO:0051858 ! avoidance of symbiont defenses + +[Term] +id: GO:0051861 +name: glycolipid binding +namespace: molecular_function +def: "Interacting selectively with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0051862 +name: translocation of molecules into symbiont +namespace: biological_process +def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction + +[Term] +id: GO:0051863 +name: translocation of DNA into symbiont +namespace: biological_process +def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +is_obsolete: true + +[Term] +id: GO:0051864 +name: histone demethylase activity (H3-K36 specific) +namespace: molecular_function +def: "Catalysis of the reaction: methyl-lysine + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. The methyl-lysine residue is at position 36 of histone 3." [PMID:16362057] +synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT [] +synonym: "H3-K36-specific demethylase activity" EXACT [EC:1.14.11.27] +synonym: "histone H3-lysine-36 demethylase activity" EXACT [EC:1.14.11.27] +synonym: "histone-lysine (H3-K36) demethylase activity" EXACT [EC:1.14.11.27] +synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT [] +synonym: "histone-lysine(H3-K36) demethylase activity" EXACT [] +synonym: "JHDM1A activity" NARROW [EC:1.14.11.27] +synonym: "JmjC domain-containing histone demethylase 1A activity" NARROW [EC:1.14.11.27] +synonym: "protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] +synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27] +xref: EC:1.14.11.27 +is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0051865 +name: protein autoubiquitination +namespace: biological_process +def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] +synonym: "protein auto-ubiquitination" EXACT [] +synonym: "protein auto-ubiquitinylation" EXACT [] +synonym: "protein autoubiquitinylation" EXACT [] +synonym: "protein self-ubiquitination" EXACT [] +synonym: "protein self-ubiquitinylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0051866 +name: general adaptation syndrome +namespace: biological_process +alt_id: GO:0051868 +def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [http://en.wikipedia.org/wiki/General_adaptation_syndrome, http://www.onelook.com] +synonym: "general adaptation syndrome, physiological process" EXACT [] +synonym: "general adaptation syndrome, physiological response" EXACT [] +synonym: "physiological process during general adaptation syndrome" EXACT [] +synonym: "physiological response during general adaptation syndrome" EXACT [] +is_a: GO:0033555 ! multicellular organismal response to stress + +[Term] +id: GO:0051867 +name: general adaptation syndrome, behavioral process +namespace: biological_process +def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai] +synonym: "behavioral process during general adaptation syndrome" EXACT [] +synonym: "behavioral response during general adaptation syndrome" EXACT [] +synonym: "behavioural process during general adaptation syndrome" EXACT [] +synonym: "behavioural response during general adaptation syndrome" EXACT [] +synonym: "general adaptation syndrome, behavioral response" EXACT [] +synonym: "general adaptation syndrome, behavioural process" EXACT [] +synonym: "general adaptation syndrome, behavioural response" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0051866 ! general adaptation syndrome + +[Term] +id: GO:0051870 +name: methotrexate binding +namespace: molecular_function +def: "Interacting selectively with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln] +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0051871 +name: dihydrofolic acid binding +namespace: molecular_function +def: "Interacting selectively with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "DHF binding" RELATED [] +synonym: "dihydrofolate binding" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0051872 +name: sphingosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai] +synonym: "(4E)-sphing-4-enine catabolic process" EXACT [] +synonym: "(4E)-sphing-4-enine catabolism" EXACT [] +synonym: "sphing-4-enine catabolic process" EXACT [] +synonym: "sphing-4-enine catabolism" EXACT [] +is_a: GO:0006670 ! sphingosine metabolic process +is_a: GO:0009310 ! amine catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0046521 ! sphingoid catabolic process + +[Term] +id: GO:0051873 +name: killing by host of symbiont cells +namespace: biological_process +def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0051852 ! disruption by host of symbiont cells +is_a: GO:0051883 ! killing of cells in other organism during symbiotic interaction + +[Term] +id: GO:0051874 +name: sphinganine-1-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT [] +synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT [] +is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process + +[Term] +id: GO:0051875 +name: pigment granule localization +namespace: biological_process +def: "Any process by which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +is_a: GO:0051648 ! vesicle localization +relationship: part_of GO:0033059 ! cellular pigmentation + +[Term] +id: GO:0051876 +name: pigment granule dispersal +namespace: biological_process +def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh] +is_a: GO:0051905 ! establishment of pigment granule localization + +[Term] +id: GO:0051877 +name: pigment granule aggregation in cell center +namespace: biological_process +def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh] +is_a: GO:0051905 ! establishment of pigment granule localization + +[Term] +id: GO:0051878 +name: lateral element assembly +namespace: biological_process +def: "The cell cycle process whereby lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007130 ! synaptonemal complex assembly + +[Term] +id: GO:0051879 +name: Hsp90 protein binding +namespace: molecular_function +def: "Interacting selectively with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] +synonym: "Hsp90 binding" EXACT [] +synonym: "Hsp90 class protein binding" EXACT [] +is_a: GO:0031072 ! heat shock protein binding + +[Term] +id: GO:0051880 +name: G-quadruplex DNA binding +namespace: molecular_function +def: "Interacting selectively with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530] +synonym: "G-DNA binding" EXACT [] +synonym: "G-quartet binding" EXACT [] +synonym: "quadruplex DNA binding" EXACT [] +synonym: "tetraplex DNA binding" EXACT [] +is_a: GO:0043566 ! structure-specific DNA binding + +[Term] +id: GO:0051881 +name: regulation of mitochondrial membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0051882 +name: mitochondrial depolarization +namespace: biological_process +def: "The process in which the membrane potential of the mitochondria changes in the depolarizing direction from the resting potential, from negative to positive." [http://en.wikipedia.org/wiki/ "Wikipedia"] +synonym: "mitochondria depolarization" EXACT [] +synonym: "mitochondrial depolarization" EXACT [] +synonym: "mitochondrial membrane depolarization" EXACT [] +synonym: "mitochondrion depolarization" EXACT [] +is_a: GO:0051881 ! regulation of mitochondrial membrane potential +is_a: GO:0051899 ! membrane depolarization + +[Term] +id: GO:0051883 +name: killing of cells in other organism during symbiotic interaction +namespace: biological_process +def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +subset: gosubset_prok +is_a: GO:0031640 ! killing of cells of another organism +is_a: GO:0051818 ! disruption of cells of other organism during symbiotic interaction + +[Term] +id: GO:0051884 +name: regulation of anagen +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0048819 ! regulation of hair follicle maturation +relationship: regulates GO:0042640 ! anagen + +[Term] +id: GO:0051885 +name: positive regulation of anagen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai] +synonym: "activation of anagen" NARROW [] +synonym: "stimulation of anagen" NARROW [] +synonym: "up regulation of anagen" EXACT [] +synonym: "up-regulation of anagen" EXACT [] +synonym: "upregulation of anagen" EXACT [] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0048818 ! positive regulation of hair follicle maturation +is_a: GO:0051884 ! regulation of anagen +relationship: positively_regulates GO:0042640 ! anagen + +[Term] +id: GO:0051886 +name: negative regulation of anagen +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai] +synonym: "down regulation of anagen" EXACT [] +synonym: "down-regulation of anagen" EXACT [] +synonym: "downregulation of anagen" EXACT [] +synonym: "inhibition of anagen" NARROW [] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0048817 ! negative regulation of hair follicle maturation +is_a: GO:0051884 ! regulation of anagen +relationship: negatively_regulates GO:0042640 ! anagen + +[Term] +id: GO:0051887 +name: regulation of exogen +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai] +is_a: GO:0048819 ! regulation of hair follicle maturation +relationship: regulates GO:0042638 ! exogen + +[Term] +id: GO:0051888 +name: positive regulation of exogen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai] +synonym: "activation of exogen" NARROW [] +synonym: "stimulation of exogen" NARROW [] +synonym: "up regulation of exogen" EXACT [] +synonym: "up-regulation of exogen" EXACT [] +synonym: "upregulation of exogen" EXACT [] +is_a: GO:0048818 ! positive regulation of hair follicle maturation +is_a: GO:0051887 ! regulation of exogen +relationship: positively_regulates GO:0042638 ! exogen + +[Term] +id: GO:0051889 +name: negative regulation of exogen +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai] +synonym: "down regulation of exogen" EXACT [] +synonym: "down-regulation of exogen" EXACT [] +synonym: "downregulation of exogen" EXACT [] +synonym: "inhibition of exogen" NARROW [] +is_a: GO:0048817 ! negative regulation of hair follicle maturation +is_a: GO:0051887 ! regulation of exogen +relationship: negatively_regulates GO:0042638 ! exogen + +[Term] +id: GO:0051890 +name: regulation of cardioblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast." [GOC:ai] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0051891 +name: positive regulation of cardioblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast." [GOC:ai] +synonym: "activation of cardioblast differentiation" NARROW [] +synonym: "stimulation of cardioblast differentiation" NARROW [] +synonym: "up regulation of cardioblast differentiation" EXACT [] +synonym: "up-regulation of cardioblast differentiation" EXACT [] +synonym: "upregulation of cardioblast differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051890 ! regulation of cardioblast differentiation +relationship: positively_regulates GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0051892 +name: negative regulation of cardioblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast." [GOC:ai] +synonym: "down regulation of cardioblast differentiation" EXACT [] +synonym: "down-regulation of cardioblast differentiation" EXACT [] +synonym: "downregulation of cardioblast differentiation" EXACT [] +synonym: "inhibition of cardioblast differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051890 ! regulation of cardioblast differentiation +relationship: negatively_regulates GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0051893 +name: regulation of focal adhesion formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +relationship: regulates GO:0048041 ! focal adhesion formation + +[Term] +id: GO:0051894 +name: positive regulation of focal adhesion formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] +synonym: "activation of focal adhesion formation" NARROW [] +synonym: "stimulation of focal adhesion formation" NARROW [] +synonym: "up regulation of focal adhesion formation" EXACT [] +synonym: "up-regulation of focal adhesion formation" EXACT [] +synonym: "upregulation of focal adhesion formation" EXACT [] +is_a: GO:0001954 ! positive regulation of cell-matrix adhesion +is_a: GO:0051893 ! regulation of focal adhesion formation +relationship: positively_regulates GO:0048041 ! focal adhesion formation + +[Term] +id: GO:0051895 +name: negative regulation of focal adhesion formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] +synonym: "down regulation of focal adhesion formation" EXACT [] +synonym: "down-regulation of focal adhesion formation" EXACT [] +synonym: "downregulation of focal adhesion formation" EXACT [] +synonym: "inhibition of focal adhesion formation" NARROW [] +is_a: GO:0001953 ! negative regulation of cell-matrix adhesion +is_a: GO:0051893 ! regulation of focal adhesion formation +relationship: negatively_regulates GO:0048041 ! focal adhesion formation + +[Term] +id: GO:0051896 +name: regulation of protein kinase B signaling cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] +synonym: "regulation of AKT signaling cascade" EXACT [] +synonym: "regulation of AKT signalling cascade" EXACT [] +synonym: "regulation of PKB signaling cascade" EXACT [] +synonym: "regulation of PKB signalling cascade" EXACT [] +synonym: "regulation of protein kinase B signalling cascade" EXACT [] +is_a: GO:0010627 ! regulation of protein kinase cascade +relationship: regulates GO:0043491 ! protein kinase B signaling cascade + +[Term] +id: GO:0051897 +name: positive regulation of protein kinase B signaling cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] +synonym: "activation of protein kinase B signaling cascade" NARROW [] +synonym: "positive regulation of AKT signaling cascade" EXACT [] +synonym: "positive regulation of AKT signalling cascade" EXACT [] +synonym: "positive regulation of PKB signaling cascade" EXACT [] +synonym: "positive regulation of PKB signalling cascade" EXACT [] +synonym: "positive regulation of protein kinase B signalling cascade" EXACT [] +synonym: "stimulation of protein kinase B signaling cascade" NARROW [] +synonym: "up regulation of protein kinase B signaling cascade" EXACT [] +synonym: "up-regulation of protein kinase B signaling cascade" EXACT [] +synonym: "upregulation of protein kinase B signaling cascade" EXACT [] +is_a: GO:0010740 ! positive regulation of protein kinase cascade +is_a: GO:0051896 ! regulation of protein kinase B signaling cascade +relationship: positively_regulates GO:0043491 ! protein kinase B signaling cascade + +[Term] +id: GO:0051898 +name: negative regulation of protein kinase B signaling cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] +synonym: "down regulation of protein kinase B signaling cascade" EXACT [] +synonym: "down-regulation of protein kinase B signaling cascade" EXACT [] +synonym: "downregulation of protein kinase B signaling cascade" EXACT [] +synonym: "inhibition of protein kinase B signaling cascade" NARROW [] +synonym: "negative regulation of AKT signaling cascade" EXACT [] +synonym: "negative regulation of AKT signalling cascade" EXACT [] +synonym: "negative regulation of PKB signaling cascade" EXACT [] +synonym: "negative regulation of PKB signalling cascade" EXACT [] +synonym: "negative regulation of protein kinase B signalling cascade" EXACT [] +is_a: GO:0010741 ! negative regulation of protein kinase cascade +is_a: GO:0051896 ! regulation of protein kinase B signaling cascade +relationship: negatively_regulates GO:0043491 ! protein kinase B signaling cascade + +[Term] +id: GO:0051899 +name: membrane depolarization +namespace: biological_process +def: "The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [http://en.wikipedia.org/wiki/Depolarization] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0051900 +name: regulation of mitochondrial depolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] +is_a: GO:0032844 ! regulation of homeostatic process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051882 ! mitochondrial depolarization + +[Term] +id: GO:0051901 +name: positive regulation of mitochondrial depolarization +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] +synonym: "activation of mitochondrial depolarization" NARROW [] +synonym: "stimulation of mitochondrial depolarization" NARROW [] +synonym: "up regulation of mitochondrial depolarization" EXACT [] +synonym: "up-regulation of mitochondrial depolarization" EXACT [] +synonym: "upregulation of mitochondrial depolarization" EXACT [] +is_a: GO:0032846 ! positive regulation of homeostatic process +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051900 ! regulation of mitochondrial depolarization +relationship: positively_regulates GO:0051882 ! mitochondrial depolarization + +[Term] +id: GO:0051902 +name: negative regulation of mitochondrial depolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] +synonym: "down regulation of mitochondrial depolarization" EXACT [] +synonym: "down-regulation of mitochondrial depolarization" EXACT [] +synonym: "downregulation of mitochondrial depolarization" EXACT [] +synonym: "inhibition of mitochondrial depolarization" NARROW [] +is_a: GO:0032845 ! negative regulation of homeostatic process +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051900 ! regulation of mitochondrial depolarization +relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization + +[Term] +id: GO:0051903 +name: S-(hydroxymethyl)glutathione dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284] +synonym: "ADH3 activity" NARROW [EC:1.1.1.284] +synonym: "chi-ADH activity" NARROW [EC:1.1.1.284] +synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "FDH activity" RELATED [EC:1.1.1.284] +synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "GD-FALDH activity" EXACT [EC:1.1.1.284] +synonym: "glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] +synonym: "GS-FDH activity" EXACT [EC:1.1.1.284] +synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] +synonym: "NAD-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] +synonym: "NAD-linked formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284] +synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.284] +xref: EC:1.1.1.284 +xref: MetaCyc:RXN-2962 +xref: UM-BBD_enzymeID:e0709 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0051904 +name: pigment granule transport +namespace: biological_process +def: "The directed movement of pigment granules into, out of, within or between cells." [GOC:ai] +synonym: "pigment granule translocation" EXACT [] +is_a: GO:0006810 ! transport +is_a: GO:0051905 ! establishment of pigment granule localization + +[Term] +id: GO:0051905 +name: establishment of pigment granule localization +namespace: biological_process +def: "The directed movement of a pigment granule to a specific location." [GOC:ai] +is_a: GO:0051650 ! establishment of vesicle localization +relationship: part_of GO:0051875 ! pigment granule localization + +[Term] +id: GO:0051906 +name: maintenance of pigment granule location +namespace: biological_process +def: "Any process by which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051655 ! maintenance of vesicle location +relationship: part_of GO:0051875 ! pigment granule localization + +[Term] +id: GO:0051907 +name: S-(hydroxymethyl)glutathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = glutathione + formaldehyde." [EC:4.4.1.22] +synonym: "Gfa" RELATED [EC:4.4.1.22] +synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT [] +synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" EXACT [EC:4.4.1.22] +synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" EXACT [EC:4.4.1.22] +xref: EC:4.4.1.22 +xref: MetaCyc:RXN-2961 +xref: UM-BBD_enzymeID:e0710 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0051908 +name: double-stranded DNA specific 5'-3' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] +is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity +is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity + +[Term] +id: GO:0051909 +name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN] +synonym: "3-hydroxypropenoate dehydratase activity" EXACT [] +synonym: "acetylenecarboxylate hydratase activity" BROAD [] +synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] +synonym: "alkynoate hydratase activity" BROAD [] +xref: EC:4.2.1.- +xref: MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0051910 +name: heparitin sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparitin = adenosine 3',5'-bisphosphate + N-sulfoheparitin." [MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN] +synonym: "heparitin N-sulfotransferase activity" EXACT [] +synonym: "heparitin N-sulphotransferase activity" EXACT [] +xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0051911 +name: Methanosarcina-phenazine hydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3] +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] +synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" EXACT [EC:1.12.98.3] +synonym: "methanophenazine hydrogenase activity" EXACT [] +synonym: "methylviologen-reducing hydrogenase activity" EXACT [] +xref: EC:1.12.98.3 +xref: MetaCyc:RXN-7733 +is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors + +[Term] +id: GO:0051912 +name: CoB--CoM heterodisulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [EC:1.8.98.1] +synonym: "CoB-CoM heterodisulfide reductase activity" EXACT [] +synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT [] +synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" EXACT [EC:1.8.98.1] +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] +synonym: "heterodisulfide reductase activity" BROAD [] +synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1] +xref: EC:1.8.98.1 +xref: MetaCyc:1.8.98.1-RXN +is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors + +[Term] +id: GO:0051913 +name: regulation of synaptic plasticity by chemical substance +namespace: biological_process +def: "The process by which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] +synonym: "regulation of synaptic plasticity by drug" NARROW [] +is_a: GO:0042221 ! response to chemical stimulus +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0051914 +name: positive regulation of synaptic plasticity by chemical substance +namespace: biological_process +def: "The process by which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] +synonym: "activation of synaptic plasticity by chemical substance" NARROW [] +synonym: "positive regulation of synaptic plasticity by drug" NARROW [] +synonym: "stimulation of synaptic plasticity by chemical substance" NARROW [] +synonym: "up regulation of synaptic plasticity by chemical substance" EXACT [] +synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT [] +synonym: "upregulation of synaptic plasticity by chemical substance" EXACT [] +is_a: GO:0031915 ! positive regulation of synaptic plasticity +is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance + +[Term] +id: GO:0051915 +name: induction of synaptic plasticity by chemical substance +namespace: biological_process +def: "The process by which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] +synonym: "activation of synaptic plasticity by chemical substance" EXACT [] +synonym: "activation of synaptic plasticity by drug" NARROW [] +synonym: "induction of synaptic plasticity by drug" NARROW [] +is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance + +[Term] +id: GO:0051916 +name: granulocyte colony-stimulating factor binding +namespace: molecular_function +def: "Interacting selectively with granulocyte colony-stimulating factor, G-CSF." [GOC:ai] +synonym: "G-CSF binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0051917 +name: regulation of fibrinolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0042730 ! fibrinolysis + +[Term] +id: GO:0051918 +name: negative regulation of fibrinolysis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] +synonym: "down regulation of fibrinolysis" EXACT [] +synonym: "down-regulation of fibrinolysis" EXACT [] +synonym: "downregulation of fibrinolysis" EXACT [] +synonym: "inhibition of fibrinolysis" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051917 ! regulation of fibrinolysis +relationship: negatively_regulates GO:0042730 ! fibrinolysis + +[Term] +id: GO:0051919 +name: positive regulation of fibrinolysis +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] +synonym: "activation of fibrinolysis" NARROW [] +synonym: "stimulation of fibrinolysis" NARROW [] +synonym: "up regulation of fibrinolysis" EXACT [] +synonym: "up-regulation of fibrinolysis" EXACT [] +synonym: "upregulation of fibrinolysis" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051917 ! regulation of fibrinolysis +relationship: positively_regulates GO:0042730 ! fibrinolysis + +[Term] +id: GO:0051920 +name: peroxiredoxin activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] +subset: gosubset_prok +synonym: "AhpC activity" NARROW [] +synonym: "alkyl hydroperoxide reductase C22 activity" NARROW [] +synonym: "PRDX activity" EXACT [] +synonym: "Prx activity" EXACT [] +synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15] +xref: EC:1.11.1.15 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0051921 +name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate." [EC:6.3.5.10] +synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT [] +synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT [] +synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.10] +synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT [] +synonym: "CobQ activity" BROAD [] +synonym: "cobyric acid synthase activity" RELATED [] +xref: EC:6.3.5.10 +xref: MetaCyc:R345-RXN +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0051922 +name: cholesterol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293] +xref: EC:2.8.2.- +is_a: GO:0004027 ! alcohol sulfotransferase activity + +[Term] +id: GO:0051923 +name: sulfation +namespace: biological_process +def: "The addition of a sulfate group to a molecule." [http://www.onelook.com] +subset: gosubset_prok +synonym: "sulfur addition" EXACT [] +synonym: "sulphation" EXACT [] +synonym: "sulphur addition" EXACT [] +is_a: GO:0006790 ! sulfur metabolic process + +[Term] +id: GO:0051924 +name: regulation of calcium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells." [GOC:ai] +synonym: "regulation of calcium transport" EXACT [] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0006816 ! calcium ion transport + +[Term] +id: GO:0051925 +name: regulation of calcium ion transport via voltage-gated calcium channel +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] +synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT [] +synonym: "regulation of voltage-gated calcium channel activity" EXACT [] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0051924 ! regulation of calcium ion transport + +[Term] +id: GO:0051926 +name: negative regulation of calcium ion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells." [GOC:ai] +synonym: "down regulation of calcium ion transport" EXACT [] +synonym: "down-regulation of calcium ion transport" EXACT [] +synonym: "downregulation of calcium ion transport" EXACT [] +synonym: "inhibition of calcium ion transport" NARROW [] +synonym: "negative regulation of calcium transport" EXACT [] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051924 ! regulation of calcium ion transport +relationship: negatively_regulates GO:0006816 ! calcium ion transport + +[Term] +id: GO:0051927 +name: negative regulation of calcium ion transport via voltage-gated calcium channel +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] +synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW [] +synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED [] +synonym: "negative regulation of voltage-gated calcium channel activity" EXACT [] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel +is_a: GO:0051926 ! negative regulation of calcium ion transport + +[Term] +id: GO:0051928 +name: positive regulation of calcium ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells." [GOC:ai] +synonym: "activation of calcium ion transport" NARROW [] +synonym: "positive regulation of calcium transport" EXACT [] +synonym: "stimulation of calcium ion transport" NARROW [] +synonym: "up regulation of calcium ion transport" EXACT [] +synonym: "up-regulation of calcium ion transport" EXACT [] +synonym: "upregulation of calcium ion transport" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051924 ! regulation of calcium ion transport +relationship: positively_regulates GO:0006816 ! calcium ion transport + +[Term] +id: GO:0051929 +name: positive regulation of calcium ion transport via voltage-gated calcium channel +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] +synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW [] +synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT [] +synonym: "positive regulation of voltage-gated calcium channel activity" EXACT [] +synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW [] +synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT [] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel +is_a: GO:0051928 ! positive regulation of calcium ion transport + +[Term] +id: GO:0051930 +name: regulation of sensory perception of pain +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +is_a: GO:0051931 ! regulation of sensory perception +relationship: regulates GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0051931 +name: regulation of sensory perception +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +is_a: GO:0031644 ! regulation of neurological system process +relationship: regulates GO:0007600 ! sensory perception + +[Term] +id: GO:0051932 +name: synaptic transmission, GABAergic +namespace: biological_process +def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [ISBN:0126603030] +synonym: "synaptic transmission, GABA mediated" EXACT [] +synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] +synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] +is_a: GO:0007270 ! nerve-nerve synaptic transmission + +[Term] +id: GO:0051933 +name: amino acid uptake during transmission of nerve impulse +namespace: biological_process +def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "amino acid neurotransmitter import into glial cell" NARROW [] +synonym: "amino acid neurotransmitter import into neuron" NARROW [] +synonym: "amino acid neurotransmitter recycling" BROAD [] +synonym: "amino acid neurotransmitter reuptake" EXACT [] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0051934 +name: catecholamine uptake during transmission of nerve impulse +namespace: biological_process +def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "catecholamine neurotransmitter import into glial cell" NARROW [] +synonym: "catecholamine neurotransmitter import into neuron" NARROW [] +synonym: "catecholamine neurotransmitter recycling" BROAD [] +synonym: "catecholamine neurotransmitter reuptake" EXACT [] +synonym: "catecholamine reuptake during transmission of nerve impulse" EXACT [] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0051935 +name: glutamate uptake during transmission of nerve impulse +namespace: biological_process +def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "glutamate import into glial cell" NARROW [] +synonym: "glutamate import into neuron" NARROW [] +synonym: "glutamate recycling" BROAD [] +synonym: "glutamate reuptake" EXACT [] +synonym: "L-glutamate reuptake" EXACT [] +synonym: "L-glutamate uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0051933 ! amino acid uptake during transmission of nerve impulse +is_a: GO:0051938 ! L-glutamate import + +[Term] +id: GO:0051936 +name: gamma-aminobutyric acid uptake during transmission of nerve impulse +namespace: biological_process +def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "GABA import into glial cell" NARROW [] +synonym: "GABA import into neuron" NARROW [] +synonym: "GABA recycling" BROAD [] +synonym: "GABA reuptake" EXACT [] +synonym: "gamma-aminobutyric acid import into glial cell" NARROW [] +synonym: "gamma-aminobutyric acid import into neuron" NARROW [] +synonym: "gamma-aminobutyric acid recycling" BROAD [] +synonym: "gamma-aminobutyric acid reuptake" EXACT [] +is_a: GO:0051933 ! amino acid uptake during transmission of nerve impulse +is_a: GO:0051939 ! gamma-aminobutyric acid import + +[Term] +id: GO:0051937 +name: catecholamine transport +namespace: biological_process +def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0015844 ! monoamine transport + +[Term] +id: GO:0051938 +name: L-glutamate import +namespace: biological_process +def: "The directed movement of L-glutamate, the levorotatory isomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015813 ! L-glutamate transport +is_a: GO:0043092 ! L-amino acid import + +[Term] +id: GO:0051939 +name: gamma-aminobutyric acid import +namespace: biological_process +def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai] +subset: gosubset_prok +synonym: "4-aminobutyrate import" EXACT [] +synonym: "GABA import" EXACT [] +synonym: "gamma-aminobutyrate import" EXACT [] +synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0015812 ! gamma-aminobutyric acid transport +is_a: GO:0043092 ! L-amino acid import + +[Term] +id: GO:0051940 +name: regulation of catecholamine uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT [] +synonym: "regulation of catecholamine neurotransmitter uptake" EXACT [] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0051934 ! catecholamine uptake during transmission of nerve impulse + +[Term] +id: GO:0051941 +name: regulation of amino acid uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "regulation of amino acid neurotransmitter reuptake" EXACT [] +synonym: "regulation of amino acid neurotransmitter uptake" EXACT [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0051933 ! amino acid uptake during transmission of nerve impulse + +[Term] +id: GO:0051942 +name: negative regulation of amino acid uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of amino acid uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of amino acid uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of amino acid uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT [] +synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse +is_a: GO:0051956 ! negative regulation of amino acid transport +relationship: negatively_regulates GO:0051933 ! amino acid uptake during transmission of nerve impulse + +[Term] +id: GO:0051943 +name: positive regulation of amino acid uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "activation of amino acid uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT [] +synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT [] +synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of amino acid uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of amino acid uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse +is_a: GO:0051957 ! positive regulation of amino acid transport +relationship: positively_regulates GO:0051933 ! amino acid uptake during transmission of nerve impulse + +[Term] +id: GO:0051944 +name: positive regulation of catecholamine uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT [] +synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT [] +synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0051934 ! catecholamine uptake during transmission of nerve impulse + +[Term] +id: GO:0051945 +name: negative regulation of catecholamine uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT [] +synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT [] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0051934 ! catecholamine uptake during transmission of nerve impulse + +[Term] +id: GO:0051946 +name: regulation of glutamate uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] +synonym: "regulation of glutamate reuptake" EXACT [] +synonym: "regulation of L-glutamate reuptake" EXACT [] +synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0002036 ! regulation of L-glutamate transport +is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse +relationship: regulates GO:0051935 ! glutamate uptake during transmission of nerve impulse + +[Term] +id: GO:0051947 +name: regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] +synonym: "regulation of 4-aminobutyrate reuptake" EXACT [] +synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] +synonym: "regulation of GABA reuptake" EXACT [] +synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT [] +synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT [] +is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse +relationship: regulates GO:0051936 ! gamma-aminobutyric acid uptake during transmission of nerve impulse + +[Term] +id: GO:0051948 +name: negative regulation of glutamate uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of glutamate reuptake" EXACT [] +is_a: GO:0002037 ! negative regulation of L-glutamate transport +is_a: GO:0051942 ! negative regulation of amino acid uptake during transmission of nerve impulse +is_a: GO:0051946 ! regulation of glutamate uptake during transmission of nerve impulse +relationship: negatively_regulates GO:0051935 ! glutamate uptake during transmission of nerve impulse + +[Term] +id: GO:0051949 +name: negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT [] +synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] +synonym: "negative regulation of GABA reuptake" EXACT [] +synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT [] +synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT [] +is_a: GO:0051942 ! negative regulation of amino acid uptake during transmission of nerve impulse +is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse +relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid uptake during transmission of nerve impulse + +[Term] +id: GO:0051950 +name: positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] +synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT [] +synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] +synonym: "positive regulation of GABA reuptake" EXACT [] +synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT [] +synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT [] +synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0051943 ! positive regulation of amino acid uptake during transmission of nerve impulse +is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse +relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid uptake during transmission of nerve impulse + +[Term] +id: GO:0051951 +name: positive regulation of glutamate uptake during transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] +synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of glutamate reuptake" EXACT [] +synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0002038 ! positive regulation of L-glutamate transport +is_a: GO:0051943 ! positive regulation of amino acid uptake during transmission of nerve impulse +is_a: GO:0051946 ! regulation of glutamate uptake during transmission of nerve impulse +relationship: positively_regulates GO:0051935 ! glutamate uptake during transmission of nerve impulse + +[Term] +id: GO:0051952 +name: regulation of amine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of, within or between cells." [GOC:ai] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015837 ! amine transport + +[Term] +id: GO:0051953 +name: negative regulation of amine transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amines into, out of, within or between cells." [GOC:ai] +synonym: "down regulation of amine transport" EXACT [] +synonym: "down-regulation of amine transport" EXACT [] +synonym: "downregulation of amine transport" EXACT [] +synonym: "inhibition of amine transport" NARROW [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051952 ! regulation of amine transport +relationship: negatively_regulates GO:0015837 ! amine transport + +[Term] +id: GO:0051954 +name: positive regulation of amine transport +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of, within or between cells." [GOC:ai] +synonym: "activation of amine transport" NARROW [] +synonym: "stimulation of amine transport" NARROW [] +synonym: "up regulation of amine transport" EXACT [] +synonym: "up-regulation of amine transport" EXACT [] +synonym: "upregulation of amine transport" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051952 ! regulation of amine transport +relationship: positively_regulates GO:0015837 ! amine transport + +[Term] +id: GO:0051955 +name: regulation of amino acid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells." [GOC:ai] +is_a: GO:0032890 ! regulation of organic acid transport +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0006865 ! amino acid transport + +[Term] +id: GO:0051956 +name: negative regulation of amino acid transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells." [GOC:ai] +synonym: "down regulation of amino acid transport" EXACT [] +synonym: "down-regulation of amino acid transport" EXACT [] +synonym: "downregulation of amino acid transport" EXACT [] +synonym: "inhibition of amino acid transport" NARROW [] +is_a: GO:0032891 ! negative regulation of organic acid transport +is_a: GO:0051953 ! negative regulation of amine transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: negatively_regulates GO:0006865 ! amino acid transport + +[Term] +id: GO:0051957 +name: positive regulation of amino acid transport +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells." [GOC:ai] +synonym: "activation of amino acid transport" NARROW [] +synonym: "stimulation of amino acid transport" NARROW [] +synonym: "up regulation of amino acid transport" EXACT [] +synonym: "up-regulation of amino acid transport" EXACT [] +synonym: "upregulation of amino acid transport" EXACT [] +is_a: GO:0032892 ! positive regulation of organic acid transport +is_a: GO:0051954 ! positive regulation of amine transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: positively_regulates GO:0006865 ! amino acid transport + +[Term] +id: GO:0051958 +name: methotrexate transport +namespace: biological_process +def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] +is_a: GO:0015893 ! drug transport + +[Term] +id: GO:0051959 +name: dynein light intermediate chain binding +namespace: molecular_function +def: "Interacting selectively with a light intermediate chain of the dynein complex." [GOC:bf] +is_a: GO:0045502 ! dynein binding + +[Term] +id: GO:0051960 +name: regulation of nervous system development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007399 ! nervous system development + +[Term] +id: GO:0051961 +name: negative regulation of nervous system development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] +synonym: "down regulation of nervous system development" EXACT [] +synonym: "down-regulation of nervous system development" EXACT [] +synonym: "downregulation of nervous system development" EXACT [] +synonym: "inhibition of nervous system development" NARROW [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051960 ! regulation of nervous system development +relationship: negatively_regulates GO:0007399 ! nervous system development + +[Term] +id: GO:0051962 +name: positive regulation of nervous system development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] +synonym: "activation of nervous system development" NARROW [] +synonym: "stimulation of nervous system development" NARROW [] +synonym: "up regulation of nervous system development" EXACT [] +synonym: "up-regulation of nervous system development" EXACT [] +synonym: "upregulation of nervous system development" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051960 ! regulation of nervous system development +relationship: positively_regulates GO:0007399 ! nervous system development + +[Term] +id: GO:0051963 +name: regulation of synaptogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai] +is_a: GO:0050807 ! regulation of synapse organization +is_a: GO:0051960 ! regulation of nervous system development +relationship: regulates GO:0007416 ! synaptogenesis + +[Term] +id: GO:0051964 +name: negative regulation of synaptogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai] +synonym: "down regulation of synaptogenesis" EXACT [] +synonym: "down-regulation of synaptogenesis" EXACT [] +synonym: "downregulation of synaptogenesis" EXACT [] +synonym: "inhibition of synaptogenesis" NARROW [] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051961 ! negative regulation of nervous system development +is_a: GO:0051963 ! regulation of synaptogenesis +relationship: negatively_regulates GO:0007416 ! synaptogenesis + +[Term] +id: GO:0051965 +name: positive regulation of synaptogenesis +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai] +synonym: "activation of synaptogenesis" NARROW [] +synonym: "stimulation of synaptogenesis" NARROW [] +synonym: "up regulation of synaptogenesis" EXACT [] +synonym: "up-regulation of synaptogenesis" EXACT [] +synonym: "upregulation of synaptogenesis" EXACT [] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051962 ! positive regulation of nervous system development +is_a: GO:0051963 ! regulation of synaptogenesis +relationship: positively_regulates GO:0007416 ! synaptogenesis + +[Term] +id: GO:0051966 +name: regulation of synaptic transmission, glutamatergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] +is_a: GO:0050804 ! regulation of synaptic transmission +relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0051967 +name: negative regulation of synaptic transmission, glutamatergic +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] +synonym: "down regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "downregulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "inhibition of synaptic transmission, glutamatergic" NARROW [] +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic +relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0051968 +name: positive regulation of synaptic transmission, glutamatergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] +synonym: "activation of synaptic transmission, glutamatergic" NARROW [] +synonym: "stimulation of synaptic transmission, glutamatergic" NARROW [] +synonym: "up regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "upregulation of synaptic transmission, glutamatergic" EXACT [] +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic +relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0051969 +name: regulation of transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0031644 ! regulation of neurological system process +relationship: regulates GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0051970 +name: negative regulation of transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] +synonym: "down regulation of transmission of nerve impulse" EXACT [] +synonym: "down-regulation of transmission of nerve impulse" EXACT [] +synonym: "downregulation of transmission of nerve impulse" EXACT [] +synonym: "inhibition of transmission of nerve impulse" NARROW [] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0031645 ! negative regulation of neurological system process +is_a: GO:0051969 ! regulation of transmission of nerve impulse +relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0051971 +name: positive regulation of transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] +synonym: "activation of transmission of nerve impulse" NARROW [] +synonym: "stimulation of transmission of nerve impulse" NARROW [] +synonym: "up regulation of transmission of nerve impulse" EXACT [] +synonym: "up-regulation of transmission of nerve impulse" EXACT [] +synonym: "upregulation of transmission of nerve impulse" EXACT [] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0031646 ! positive regulation of neurological system process +is_a: GO:0051969 ! regulation of transmission of nerve impulse +relationship: positively_regulates GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0051972 +name: regulation of telomerase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai] +subset: gosubset_prok +synonym: "telomerase regulator" EXACT [] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0051973 +name: positive regulation of telomerase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] +synonym: "activation of telomerase activity" NARROW [] +synonym: "stimulation of telomerase activity" NARROW [] +synonym: "telomerase activator" RELATED [] +synonym: "up regulation of telomerase activity" EXACT [] +synonym: "up-regulation of telomerase activity" EXACT [] +synonym: "upregulation of telomerase activity" EXACT [] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:0051972 ! regulation of telomerase activity + +[Term] +id: GO:0051974 +name: negative regulation of telomerase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] +subset: gosubset_prok +synonym: "down regulation of telomerase activity" EXACT [] +synonym: "down-regulation of telomerase activity" EXACT [] +synonym: "downregulation of telomerase activity" EXACT [] +synonym: "inhibition of telomerase activity" NARROW [] +synonym: "telomerase inhibitor" RELATED [] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:0051972 ! regulation of telomerase activity + +[Term] +id: GO:0051975 +name: lysine biosynthetic process via alpha-aminoadipate and saccharopine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY] +synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [] +synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [] +xref: MetaCyc:LYSINE-AMINOAD-PWY +is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid + +[Term] +id: GO:0051976 +name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081] +synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] +synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] +xref: MetaCyc:PWY-3081 +is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid + +[Term] +id: GO:0051977 +name: lysophospholipid transport +namespace: biological_process +def: "The directed movement of phospholipids into, out of, within or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] +is_a: GO:0015914 ! phospholipid transport + +[Term] +id: GO:0051978 +name: lysophospholipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of lysophospholipids into, out of, within or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] +subset: gosubset_prok +is_a: GO:0005548 ! phospholipid transporter activity + +[Term] +id: GO:0051979 +name: alginic acid acetylation +namespace: biological_process +def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg] +synonym: "alginate acetylation" EXACT [] +is_a: GO:0042120 ! alginic acid metabolic process + +[Term] +id: GO:0051980 +name: iron-nicotianamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai] +synonym: "Fe-NA chelate transporter activity" EXACT [] +is_a: GO:0015603 ! iron chelate transmembrane transporter activity + +[Term] +id: GO:0051981 +name: copper chelate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] +subset: gosubset_prok +is_a: GO:0005375 ! copper ion transmembrane transporter activity + +[Term] +id: GO:0051982 +name: copper-nicotianamine transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai] +synonym: "Cu-NA chelate transporter activity" EXACT [] +is_a: GO:0051981 ! copper chelate transmembrane transporter activity + +[Term] +id: GO:0051983 +name: regulation of chromosome segregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051984 +name: positive regulation of chromosome segregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +synonym: "activation of chromosome segregation" NARROW [] +synonym: "stimulation of chromosome segregation" NARROW [] +synonym: "up regulation of chromosome segregation" EXACT [] +synonym: "up-regulation of chromosome segregation" EXACT [] +synonym: "upregulation of chromosome segregation" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: positively_regulates GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051985 +name: negative regulation of chromosome segregation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +synonym: "down regulation of chromosome segregation" EXACT [] +synonym: "down-regulation of chromosome segregation" EXACT [] +synonym: "downregulation of chromosome segregation" EXACT [] +synonym: "inhibition of chromosome segregation" NARROW [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: negatively_regulates GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051986 +name: negative regulation of attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] +synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW [] +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:0051985 ! negative regulation of chromosome segregation +is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore +relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore + +[Term] +id: GO:0051987 +name: positive regulation of attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] +synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW [] +synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW [] +synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT [] +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0051984 ! positive regulation of chromosome segregation +is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore +relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore + +[Term] +id: GO:0051988 +name: regulation of attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0032886 ! regulation of microtubule-based process +is_a: GO:0051983 ! regulation of chromosome segregation +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore + +[Term] +id: GO:0051989 +name: coproporphyrinogen dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.99.22] +synonym: "coproporphyrinogen III oxidase activity" EXACT [EC:1.3.99.22] +synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.22] +synonym: "HemN" RELATED [EC:1.3.99.22] +synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT [] +synonym: "radical SAM enzyme activity" RELATED [EC:1.3.99.22] +xref: EC:1.3.99.22 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0051990 +name: (R)-2-hydroxyglutarate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] +subset: gosubset_prok +synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT [] +xref: EC:1.1.1.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0052000 +name: Type IV pili-dependent aggregation +namespace: biological_process +def: "The formation of bacterial aggregates in liquid culture dependent on the presence of Type IV pili." [GOC:ml] +subset: gosubset_prok +synonym: "auto-aggregation" BROAD [] +synonym: "bfp-dependent aggregation" EXACT [] +synonym: "bundle-forming fimbriae-dependent aggregation" EXACT [] +synonym: "bundle-forming pili-dependent aggregation" EXACT [] +synonym: "tfp-dependent aggregation" EXACT [] +is_a: GO:0016337 ! cell-cell adhesion + +[Term] +id: GO:0052001 +name: Type IV pili-dependent localized adherence to host +namespace: biological_process +def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml] +subset: gosubset_prok +is_a: GO:0044406 ! adhesion to host + +[Term] +id: GO:0052002 +name: metabolism by symbiont of substance in host +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052003 +name: negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] +synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] +is_a: GO:0052004 ! negative regulation by symbiont of host salicylic acid-mediated defense response +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +is_a: GO:0052252 ! negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction + +[Term] +id: GO:0052004 +name: negative regulation by symbiont of host salicylic acid-mediated defense response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW [] +synonym: "negative regulation of host SA-mediated defense response" EXACT [] +synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT [] +synonym: "suppression of host SA mediated defense response" EXACT [] +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response +is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052005 +name: negative regulation by symbiont of host ethylene-mediated defense response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW [] +synonym: "suppression by organism of host ethylene-mediated defense response" EXACT [] +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response +is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052006 +name: catabolism by symbiont of substance in host +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism by organism of substance in host" EXACT [] +is_a: GO:0052002 ! metabolism by symbiont of substance in host +is_a: GO:0052227 ! catabolism of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052007 +name: biosynthesis by symbiont of substance in host +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "biosynthesis by organism of substance in host" EXACT [] +is_a: GO:0052002 ! metabolism by symbiont of substance in host +is_a: GO:0052226 ! biosynthesis of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052008 +name: disassembly by symbiont of host cellular component +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "catabolism of host cellular component by organism" EXACT [] +synonym: "catabolism of host structural constituent by organism" EXACT [] +synonym: "degradation of host cellular component by organism" EXACT [] +synonym: "disassembly by organism of host cellular component" EXACT [] +is_a: GO:0052043 ! modification by symbiont of host cellular component +is_a: GO:0052368 ! disassembly by organism of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052009 +name: disassembly by symbiont of host cell wall +namespace: biological_process +def: "The breakdown of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "catabolism of host cell wall by organism" EXACT [] +synonym: "degradation of host cell wall by organism" EXACT [] +synonym: "disassembly by organism of host cell wall" EXACT [] +is_a: GO:0052008 ! disassembly by symbiont of host cellular component +is_a: GO:0052020 ! modification by symbiont of host cell wall +is_a: GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052010 +name: catabolism by symbiont of host cell wall cellulose +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "catabolism by organism of host cell wall cellulose" EXACT [] +is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate +is_a: GO:0052172 ! metabolism by symbiont of host cell wall cellulose +is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism during symbiotic interaction +relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall + +[Term] +id: GO:0052011 +name: catabolism by symbiont of host cell wall pectin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "catabolism by organism of host cell wall pectin" EXACT [] +is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate +is_a: GO:0052179 ! metabolism by symbiont of host cell wall pectin +is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism during symbiotic interaction +relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall + +[Term] +id: GO:0052012 +name: catabolism by symbiont of host cell wall chitin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "catabolism by organism of host cell wall chitin" EXACT [] +is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate +is_a: GO:0052178 ! metabolism by symbiont of host cell wall chitin +is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism during symbiotic interaction +relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall + +[Term] +id: GO:0052013 +name: catabolism by symbiont of host macromolecule +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism by organism of host macromolecule" EXACT [] +is_a: GO:0052006 ! catabolism by symbiont of substance in host +is_a: GO:0052174 ! metabolism by symbiont of host macromolecule +is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction + +[Term] +id: GO:0052014 +name: catabolism by symbiont of host protein +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism by organism of host protein" EXACT [] +is_a: GO:0052013 ! catabolism by symbiont of host macromolecule +is_a: GO:0052228 ! metabolism by symbiont of host protein +is_a: GO:0052363 ! catabolism by organism of protein in other organism during symbiotic interaction + +[Term] +id: GO:0052015 +name: catabolism by symbiont of host carbohydrate +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism by organism of host carbohydrate" EXACT [] +is_a: GO:0052013 ! catabolism by symbiont of host macromolecule +is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052016 +name: catabolism by symbiont of host glucan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism by organism of host glucan" EXACT [] +is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate +is_a: GO:0052176 ! metabolism by symbiont of host glucan +is_a: GO:0052359 ! catabolism by organism of glucan in other organism during symbiotic interaction + +[Term] +id: GO:0052017 +name: catabolism by symbiont of host xylan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism by organism of host xylan" EXACT [] +is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate +is_a: GO:0052177 ! metabolism by symbiont of host xylan +is_a: GO:0052366 ! catabolism by organism of xylan in other organism during symbiotic interaction + +[Term] +id: GO:0052018 +name: modulation by symbiont of host RNA levels +namespace: biological_process +def: "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052249 ! modulation of RNA levels in other organism during symbiotic interaction + +[Term] +id: GO:0052019 +name: modulation by symbiont of host hormone or growth regulator levels +namespace: biological_process +def: "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction + +[Term] +id: GO:0052020 +name: modification by symbiont of host cell wall +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "metabolism of host cell wall by organism" EXACT [] +is_a: GO:0052043 ! modification by symbiont of host cellular component +is_a: GO:0052333 ! modification by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052021 +name: modulation by symbiont of ethylene levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels +is_a: GO:0052449 ! modulation by organism of ethylene levels in other organism during symbiotic interaction + +[Term] +id: GO:0052022 +name: modulation by symbiont of jasmonic acid levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels +is_a: GO:0052456 ! modulation by organism of jasmonic acid levels in other organism during symbiotic interaction + +[Term] +id: GO:0052023 +name: modulation by symbiont of salicylic acid levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels +is_a: GO:0052469 ! modulation by organism of salicylic acid levels in other organism during symbiotic interaction + +[Term] +id: GO:0052024 +name: positive regulation by symbiont of hormone or growth regulator levels in host +namespace: biological_process +def: "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW [] +synonym: "positive modulation of hormone or growth regulator levels in host" EXACT [] +synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW [] +synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT [] +synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT [] +synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT [] +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels +is_a: GO:0052513 ! positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction + +[Term] +id: GO:0052025 +name: modification by symbiont of host cell membrane +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the host cell membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052043 ! modification by symbiont of host cellular component +is_a: GO:0052332 ! modification by organism of cell membrane in other organism during symbiotic interaction + +[Term] +id: GO:0052026 +name: modulation by symbiont of host transcription +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of host transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052312 ! modulation of transcription in other organism during symbiotic interaction + +[Term] +id: GO:0052027 +name: modulation by symbiont of host signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052028 +name: positive regulation by symbiont of host signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host signal transduction pathway" NARROW [] +synonym: "stimulation by symbiont of host signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "upregulation by symbiont of host signal transduction pathway" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway +is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052029 +name: negative regulation by symbiont of host signal transduction pathway +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of host signal transduction pathway" NARROW [] +synonym: "negative modulation by organism of host signal transduction pathway" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway +is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052030 +name: induction by symbiont of host apoptosis +namespace: biological_process +def: "Any process by which an organism activates programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of host apoptosis" EXACT [] +synonym: "activation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "induction by organism of host apoptotic programmed cell death" EXACT [] +is_a: GO:0052044 ! induction by symbiont of host programmed cell death +is_a: GO:0052151 ! positive regulation by symbiont of host apoptosis +is_a: GO:0052388 ! induction by organism of apoptosis in other organism during symbiotic interaction + +[Term] +id: GO:0052031 +name: modulation by symbiont of host defense response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052200 ! response to host defenses +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052032 +name: modulation by symbiont of host inflammatory response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism during symbiotic interaction + +[Term] +id: GO:0052033 +name: pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity +namespace: biological_process +subset: gosubset_prok +synonym: "general elicitor-dependent activation of host innate immunity" EXACT [] +synonym: "general elicitor-dependent induction of host innate immunity" EXACT [] +synonym: "MAMP dependent activation of host innate immunity" EXACT [] +synonym: "MAMP dependent induction of host innate immunity" EXACT [] +synonym: "PAMP dependent activation of host innate immunity" EXACT [] +synonym: "PAMP dependent induction of host innate immunity" EXACT [] +synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT [] +is_a: GO:0052166 ! positive regulation by symbiont of host innate immunity +is_a: GO:0052169 ! pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity +is_a: GO:0052257 ! pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction + +[Term] +id: GO:0052034 +name: negative regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity +namespace: biological_process +subset: gosubset_prok +synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] +synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] +synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] +synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW [] +synonym: "suppression of general elicitor induced host innate immunity" EXACT [] +synonym: "suppression of general elicitor-induced host innate immunity" EXACT [] +synonym: "suppression of MAMP induced host innate immunity" EXACT [] +synonym: "suppression of MAMP-induced host innate immunity" EXACT [] +synonym: "suppression of PAMP induced host innate immunity" EXACT [] +synonym: "suppression of PAMP-induced host innate immunity" EXACT [] +synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" EXACT [] +is_a: GO:0052157 ! modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity +is_a: GO:0052170 ! negative regulation by symbiont of host innate immunity +is_a: GO:0052258 ! negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction + +[Term] +id: GO:0052035 +name: positive regulation by symbiont of host inflammatory response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host inflammatory response" NARROW [] +synonym: "stimulation by symbiont of host inflammatory response" NARROW [] +synonym: "up regulation by symbiont of host inflammatory response" EXACT [] +synonym: "up-regulation by symbiont of host inflammatory response" EXACT [] +synonym: "upregulation by symbiont of host inflammatory response" EXACT [] +is_a: GO:0052032 ! modulation by symbiont of host inflammatory response +is_a: GO:0052259 ! positive regulation by organism of inflammatory response of other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0052036 +name: negative regulation by symbiont of host inflammatory response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host inflammatory response" EXACT [] +synonym: "down-regulation by symbiont of host inflammatory response" EXACT [] +synonym: "downregulation by symbiont of host inflammatory response" EXACT [] +synonym: "inhibition by symbiont of host inflammatory response" NARROW [] +is_a: GO:0052032 ! modulation by symbiont of host inflammatory response +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052260 ! negative regulation by organism of inflammatory response of other organism during symbiotic interaction + +[Term] +id: GO:0052037 +name: negative regulation by symbiont of host defense response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host defense response" EXACT [] +synonym: "down-regulation by symbiont of host defense response" EXACT [] +synonym: "downregulation by symbiont of host defense response" EXACT [] +synonym: "inhibition by symbiont of host defense response" NARROW [] +synonym: "suppression of host defense response" EXACT [] +is_a: GO:0044414 ! suppression of host defenses +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052038 +name: modulation by symbiont of host intracellular transport +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of host intracellular trafficking" EXACT [] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052230 ! modulation of intracellular transport in other organism during symbiotic interaction + +[Term] +id: GO:0052039 +name: modification by symbiont of host cytoskeleton +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052043 ! modification by symbiont of host cellular component +is_a: GO:0052334 ! modification by organism of cytoskeleton in other organism during symbiotic interaction + +[Term] +id: GO:0052040 +name: modulation by symbiont of host programmed cell death +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of host PCD" EXACT [] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052041 +name: negative regulation by symbiont of host programmed cell death +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host programmed cell death" EXACT [] +synonym: "down-regulation by symbiont of host programmed cell death" EXACT [] +synonym: "downregulation by symbiont of host programmed cell death" EXACT [] +synonym: "inhibition by symbiont of host programmed cell death" NARROW [] +synonym: "inhibition of host programmed cell death" EXACT [] +synonym: "suppression by symbiont of host PCD" EXACT [] +synonym: "suppression by symbiont of host programmed cell death" EXACT [] +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052042 +name: positive regulation by symbiont of host programmed cell death +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host programmed cell death" NARROW [] +synonym: "enhancement of host programmed cell death" EXACT [] +synonym: "stimulation by symbiont of host programmed cell death" NARROW [] +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction +relationship: part_of GO:0001907 ! killing by symbiont of host cells + +[Term] +id: GO:0052043 +name: modification by symbiont of host cellular component +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052111 ! modification by symbiont of host structure +is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052044 +name: induction by symbiont of host programmed cell death +namespace: biological_process +def: "The activation by an organism of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of host programmed cell death" EXACT [] +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052400 ! induction by organism of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052045 +name: upregulation by symbiont of host programmed cell death +namespace: biological_process +def: "Any process by which an organism increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "enhancement of host programmed cell death by organism" EXACT [] +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052529 ! upregulation by organism of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052046 +name: modification by symbiont of host morphology or physiology via secreted substance +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modification of host morphology or physiology via effector molecule" NARROW [] +synonym: "modification of host morphology or physiology via ellicitor" NARROW [] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052048 ! interaction with host via secreted substance +is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052047 +name: interaction with other organism via secreted substance during symbiotic interaction +namespace: biological_process +def: "An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0052048 +name: interaction with host via secreted substance +namespace: biological_process +def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051701 ! interaction with host +is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052049 +name: interaction with host via protein secreted by type III secretion system +namespace: biological_process +def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052048 ! interaction with host via secreted substance +is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system during symbiotic interaction + +[Term] +id: GO:0052050 +name: interaction with host via substance secreted by type IV secretion system +namespace: biological_process +def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052048 ! interaction with host via secreted substance +is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction + +[Term] +id: GO:0052051 +name: interaction with host via protein secreted by type II secretion system +namespace: biological_process +def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052048 ! interaction with host via secreted substance +is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system during symbiotic interaction + +[Term] +id: GO:0052052 +name: modification by symbiont of host morphology or physiology via protein secreted by type II secretion system +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance +is_a: GO:0052051 ! interaction with host via protein secreted by type II secretion system +is_a: GO:0052206 ! modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction + +[Term] +id: GO:0052053 +name: negative regulation by symbiont of host enzyme activity +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host enzyme activity" EXACT [] +synonym: "down-regulation by symbiont of host enzyme activity" EXACT [] +synonym: "downregulation by symbiont of host enzyme activity" EXACT [] +synonym: "inhibition by symbiont of host enzyme activity" NARROW [] +synonym: "inhibition of host enzyme activity" EXACT [] +is_a: GO:0052056 ! negative regulation by symbiont of host molecular function +is_a: GO:0052148 ! modification by symbiont of host catalytic activity +is_a: GO:0052199 ! negative regulation of catalytic activity in other organism during symbiotic interaction + +[Term] +id: GO:0052054 +name: negative regulation by symbiont of host peptidase activity +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "down regulation by symbiont of host protease activity" EXACT [] +synonym: "down-regulation by symbiont of host protease activity" EXACT [] +synonym: "downregulation by symbiont of host protease activity" EXACT [] +synonym: "inhibition by symbiont of host protease activity" NARROW [] +synonym: "inhibition of host protease activity" EXACT [] +synonym: "negative regulation by symbiont of host protease activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052053 ! negative regulation by symbiont of host enzyme activity +is_a: GO:0052149 ! modification by symbiont of host protease activity +is_a: GO:0052180 ! negative regulation of peptidase activity in other organism during symbiotic interaction + +[Term] +id: GO:0052055 +name: modification by symbiont of host molecular function +namespace: biological_process +def: "The process by which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance +is_a: GO:0052205 ! modification of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0052056 +name: negative regulation by symbiont of host molecular function +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "down regulation by symbiont of host protein function" EXACT [] +synonym: "down-regulation by symbiont of host protein function" EXACT [] +synonym: "downregulation by symbiont of host protein function" EXACT [] +synonym: "inhibition by symbiont of host protein function" NARROW [] +synonym: "inhibition of host protein function" EXACT [] +synonym: "negative regulation by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052055 ! modification by symbiont of host molecular function +is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0052057 +name: modification by symbiont of host morphology or physiology via protein secreted by type III secretion system +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance +is_a: GO:0052049 ! interaction with host via protein secreted by type III secretion system +is_a: GO:0052207 ! modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction + +[Term] +id: GO:0052058 +name: modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance +is_a: GO:0052050 ! interaction with host via substance secreted by type IV secretion system +is_a: GO:0052208 ! modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction + +[Term] +id: GO:0052059 +name: evasion or tolerance by symbiont of host-produced reactive oxygen species +namespace: biological_process +def: "The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion by organism of cellular damage caused by host oxidative burst" NARROW [] +synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT [] +synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT [] +synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT [] +synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT [] +synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT [] +synonym: "evasion or tolerance of host-produced active oxygen species" EXACT [] +synonym: "evasion or tolerance of host-produced AOS" EXACT [] +synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT [] +synonym: "evasion or tolerance of host-produced ROIs" EXACT [] +synonym: "evasion or tolerance of host-produced ROS" EXACT [] +synonym: "evasion or tolerance of reactive oxygen species produced by host in response to organism" EXACT [] +is_a: GO:0020012 ! evasion or tolerance of host immune response +is_a: GO:0052385 ! evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction +is_a: GO:0052567 ! response to defense-related host reactive oxygen species production + +[Term] +id: GO:0052060 +name: evasion or tolerance by symbiont of host-produced nitric oxide +namespace: biological_process +def: "The process by which an organism avoids the effects of nitric oxide produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion or tolerance by organism of host nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of host NO" EXACT [] +synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of host-produced NO" EXACT [] +synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT [] +synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT [] +is_a: GO:0020012 ! evasion or tolerance of host immune response +is_a: GO:0052376 ! evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction +is_a: GO:0052565 ! response to defense-related host nitric oxide production + +[Term] +id: GO:0052061 +name: evasion or tolerance by symbiont of host-produced phytoalexins +namespace: biological_process +def: "The process by which an organism avoids the effects of phytoalexins produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion or tolerance by organism of host phytoalexins" EXACT [] +synonym: "evasion or tolerance by organism of host-produced phytoalexins" EXACT [] +synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT [] +synonym: "host phytoalexin detoxification" NARROW [] +is_a: GO:0020012 ! evasion or tolerance of host immune response +is_a: GO:0052378 ! evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction +is_a: GO:0052566 ! response to host phytoalexin production + +[Term] +id: GO:0052062 +name: induction by symbiont of host phytoalexin production +namespace: biological_process +def: "The activation by an organism of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of host phytoalexin production" EXACT [] +is_a: GO:0052262 ! induction by organism of phytoalexin production in other organism during symbiotic interaction +is_a: GO:0052344 ! positive regulation by symbiont of host phytoalexin production +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052063 +name: induction by symbiont of defense-related host nitric oxide production +namespace: biological_process +def: "The activation by an organism of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host nitric oxide production" EXACT [] +synonym: "activation by organism of defense-related host NO production" EXACT [] +synonym: "induction by organism of defense-related host NO production" EXACT [] +is_a: GO:0052263 ! induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction +is_a: GO:0052347 ! positive regulation by symbiont of defense-related host nitric oxide production +is_a: GO:0052509 ! positive regulation by symbiont of host defense response +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052064 +name: induction by symbiont of defense-related host reactive oxygen species production +namespace: biological_process +def: "The activation by an organism of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host active oxygen species production" EXACT [] +synonym: "activation by organism of defense-related host AOS production" EXACT [] +synonym: "activation by organism of defense-related host metabolic burst" EXACT [] +synonym: "activation by organism of defense-related host oxidative burst" EXACT [] +synonym: "activation by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "activation by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "activation by organism of defense-related host reactive oxygen species production" EXACT [] +synonym: "activation by organism of defense-related host respiratory burst" EXACT [] +synonym: "activation by organism of defense-related host ROI production" EXACT [] +synonym: "activation by organism of defense-related host ROS production" EXACT [] +synonym: "induction by organism of defense-related host active oxygen species production" EXACT [] +synonym: "induction by organism of defense-related host AOS production" EXACT [] +synonym: "induction by organism of defense-related host metabolic burst" EXACT [] +synonym: "induction by organism of defense-related host oxidative burst" EXACT [] +synonym: "induction by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "induction by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "induction by organism of defense-related host respiratory burst" EXACT [] +synonym: "induction by organism of defense-related host ROI production" EXACT [] +synonym: "induction by organism of defense-related host ROS production" EXACT [] +is_a: GO:0052264 ! induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +is_a: GO:0052369 ! positive regulation by symbiont of defense-related host reactive oxygen species production +is_a: GO:0052509 ! positive regulation by symbiont of host defense response +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052065 +name: positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" RELATED [] +synonym: "stimulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052066 +name: entry of symbiont into host cell by promotion of host phagocytosis +namespace: biological_process +def: "The invasion by an organism of a cell of its host organism by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT [] +is_a: GO:0030260 ! entry into host cell +is_a: GO:0052191 ! positive regulation by symbiont of host phagocytosis +is_a: GO:0052370 ! entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052067 +name: negative regulation by symbiont of entry into host cell via phagocytosis +namespace: biological_process +def: "Any process by which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of entry into host cell via phagocytosis" EXACT [] +synonym: "down-regulation by symbiont of entry into host cell via phagocytosis" EXACT [] +synonym: "downregulation by symbiont of entry into host cell via phagocytosis" EXACT [] +synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW [] +synonym: "negative regulation by organism of entry into host cell via host phagocytosis" EXACT [] +is_a: GO:0044415 ! evasion or tolerance of host defenses +is_a: GO:0052374 ! negative regulation by symbiont of entry into host +is_a: GO:0052380 ! modulation by symbiont of entry into host via phagocytosis +is_a: GO:0052483 ! negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction + +[Term] +id: GO:0052068 +name: negative regulation by symbiont of host jasmonic acid-mediated defense response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "suppression by organism of host JA-mediated defense response" EXACT [] +is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response +is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052562 ! negative regulation by symbiont of host immune response + +[Term] +id: GO:0052069 +name: negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "negative regulation by organism of defense-related host JA-mediated signal transduction pathway" EXACT [] +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0052068 ! negative regulation by symbiont of host jasmonic acid-mediated defense response +is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway +is_a: GO:0052267 ! negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052070 +name: negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW [] +synonym: "suppression by organism of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +is_a: GO:0052005 ! negative regulation by symbiont of host ethylene-mediated defense response +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway +is_a: GO:0052268 ! negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052071 +name: positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW [] +synonym: "stimulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT [] +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0052076 ! positive regulation by symbiont of host ethylene-mediated defense response +is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway +is_a: GO:0052269 ! positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052072 +name: positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0052074 ! positive regulation by symbiont of host salicylic acid-mediated defense response +is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +is_a: GO:0052270 ! positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052073 +name: positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] +synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT [] +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0052075 ! positive regulation by symbiont of host jasmonic acid-mediated defense response +is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway +is_a: GO:0052271 ! positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052074 +name: positive regulation by symbiont of host salicylic acid-mediated defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW [] +synonym: "induction by organism of host SA-mediated defense response" NARROW [] +synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of host SA-mediated defense response" EXACT [] +synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW [] +synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response +is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0052075 +name: positive regulation by symbiont of host jasmonic acid-mediated defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "induction by organism of host JA-mediated defense response" NARROW [] +synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of host JA-mediated defense response" EXACT [] +synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response +is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052076 +name: positive regulation by symbiont of host ethylene-mediated defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of host ethylene-mediated defense response" NARROW [] +synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW [] +synonym: "induction by organism of host ethylene-mediated defense response" NARROW [] +synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW [] +synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "upregulation by organism of host ethylene-mediated defense response" NARROW [] +synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT [] +is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response +is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0052077 +name: modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052078 +name: negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +is_a: GO:0052275 ! negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0075132 ! negative regulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0052079 +name: positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response +is_a: GO:0075131 ! positive regulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0052080 +name: modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" EXACT [] +synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0052081 +name: modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway +is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052082 +name: modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of defense-related host JA-mediated signal transduction pathway by organism" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052083 +name: negative regulation by symbiont of host cell-mediated immune response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT [] +synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT [] +synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT [] +synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW [] +synonym: "negative regulation by organism of host cell-based immune response" EXACT [] +is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response +is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction +is_a: GO:0052562 ! negative regulation by symbiont of host immune response + +[Term] +id: GO:0052084 +name: modulation by symbiont of host ethylene-mediated defense response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052085 +name: negative regulation by symbiont of host T-cell mediated immune response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT [] +synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT [] +synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT [] +synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW [] +is_a: GO:0052083 ! negative regulation by symbiont of host cell-mediated immune response +is_a: GO:0052156 ! modulation by symbiont of host T-cell mediated immune response +is_a: GO:0052280 ! negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052086 +name: negative regulation by symbiont of host B-cell mediated immune response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT [] +synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT [] +synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT [] +synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW [] +is_a: GO:0052154 ! modulation by symbiont of host B-cell mediated immune response +is_a: GO:0052281 ! negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction +is_a: GO:0052562 ! negative regulation by symbiont of host immune response + +[Term] +id: GO:0052087 +name: negative regulation by symbiont of defense-related host callose deposition +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of callose deposition performed by the host as part of its defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of defense-related host callose deposition" EXACT [] +synonym: "down-regulation by symbiont of defense-related host callose deposition" EXACT [] +synonym: "downregulation by symbiont of defense-related host callose deposition" EXACT [] +synonym: "inhibition by symbiont of defense-related host callose deposition" NARROW [] +synonym: "suppression by organism of defense-related host callose deposition" EXACT [] +is_a: GO:0052037 ! negative regulation by symbiont of host defense response +is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition +is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction + +[Term] +id: GO:0052088 +name: modulation by symbiont of host jasmonic acid-mediated defense response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of host JA-mediated defense response" EXACT [] +is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052089 +name: modulation by symbiont of host salicylic acid-mediated defense response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of host SA-mediated defense response" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052090 +name: modulation by symbiont of defense-related host callose deposition +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction + +[Term] +id: GO:0052091 +name: modulation by symbiont of nutrient release from host +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052313 ! modulation of nutrient release from other organism during symbiotic interaction +relationship: part_of GO:0044002 ! acquisition of nutrients from host + +[Term] +id: GO:0052092 +name: positive regulation by symbiont of nutrient release from host +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of nutrient release from host" NARROW [] +synonym: "promotion of nutrient release from host" EXACT [] +synonym: "stimulation by symbiont of nutrient release from host" NARROW [] +synonym: "up regulation by symbiont of nutrient release from host" EXACT [] +synonym: "up-regulation by symbiont of nutrient release from host" EXACT [] +synonym: "upregulation by symbiont of nutrient release from host" EXACT [] +is_a: GO:0052091 ! modulation by symbiont of nutrient release from host +is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism during symbiotic interaction + +[Term] +id: GO:0052093 +name: formation of specialized structure for nutrient acquisition from host +namespace: biological_process +def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT [] +synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT [] +is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction +is_a: GO:0052108 ! growth or development of symbiont during interaction with host +relationship: part_of GO:0044002 ! acquisition of nutrients from host + +[Term] +id: GO:0052094 +name: formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "The assembly by an organism of a haustorium, a projection from a cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.onelook.com] +synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT [] +synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host +is_a: GO:0075065 ! growth or development of symbiont in host cell + +[Term] +id: GO:0052095 +name: formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction +namespace: biological_process +def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0048646 ! anatomical structure formation +is_a: GO:0052171 ! growth or development during symbiotic interaction +relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction + +[Term] +id: GO:0052096 +name: formation by symbiont of syncytium involving giant cell for nutrient acquisition from host +namespace: biological_process +def: "The assembly by an organism of a syncytium, a nematode-induced multi-nucleate and physiologically active aggregation of fused root cells which exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "formation by organism of syncitium involving giant cell for nutrient acquisition from host" EXACT [] +synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host + +[Term] +id: GO:0052097 +name: interspecies quorum sensing +namespace: biological_process +def: "The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0009372 ! quorum sensing +is_a: GO:0044419 ! interspecies interaction between organisms + +[Term] +id: GO:0052098 +name: formation by host of specialized structure for nutrient acquisition from symbiont +namespace: biological_process +def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051850 ! acquisition of nutrients from symbiont +is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction + +[Term] +id: GO:0052099 +name: acquisition by symbiont of nutrients from host via siderophores +namespace: biological_process +synonym: "acquisition by organism of nutrients from host via siderophores" EXACT [] +is_a: GO:0044002 ! acquisition of nutrients from host + +[Term] +id: GO:0052100 +name: intraspecies quorum sensing +namespace: biological_process +def: "The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0009372 ! quorum sensing +is_a: GO:0051703 ! intraspecies interaction between organisms + +[Term] +id: GO:0052101 +name: induction by symbiont of host resistance gene-dependent defense response +namespace: biological_process +def: "The activation by an organism of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense response in host by specific elicitors" EXACT [] +synonym: "activation by organism of host gene-for-gene resistance" EXACT [] +synonym: "activation by organism of host resistance gene-dependent defense response" EXACT [] +synonym: "activation by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT [] +synonym: "induction by organism of defense response in host by specific elicitors" EXACT [] +synonym: "induction by organism of host gene-for-gene resistance" EXACT [] +synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT [] +is_a: GO:0052286 ! induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +is_a: GO:0052527 ! positive regulation by symbiont of host resistance gene-dependent defense response +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052102 +name: positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] +synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT [] +synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] +synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] +is_a: GO:0052168 ! modulation by symbiont of defense-related host calcium-dependent protein kinase pathway +is_a: GO:0052287 ! positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0052103 +name: induction by symbiont of induced systemic resistance in host +namespace: biological_process +def: "Any process by which an organism activates induced systemic resistance in the host; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of induced systemic resistance in host" EXACT [] +synonym: "activation by organism of ISR in host" EXACT [] +synonym: "induction by organism of ISR in host" EXACT [] +is_a: GO:0052288 ! induction by organism of induced systemic resistance in other organism during symbiotic interaction +is_a: GO:0052533 ! positive regulation by symbiont of induced systemic resistance in host +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052104 +name: induction by symbiont of systemic acquired resistance in host +namespace: biological_process +def: "Any process by which an organism activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of SAR in host" EXACT [] +synonym: "activation by organism of systemic acquired resistance in host" EXACT [] +synonym: "induction by organism of SAR in host" EXACT [] +is_a: GO:0052289 ! induction by organism of systemic acquired resistance in other organism during symbiotic interaction +is_a: GO:0052537 ! positive regulation by symbiont of systemic acquired resistance in host +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052105 +name: induction by symbiont of defense-related host cell wall thickening +namespace: biological_process +def: "The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related host cell wall thickening" EXACT [] +synonym: "activation by organism of host defensive cell wall thickening" EXACT [] +synonym: "induction by organism of host defensive cell wall thickening" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052290 ! induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction +is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening + +[Term] +id: GO:0052106 +name: quorum sensing during interaction with host +namespace: biological_process +def: "The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052097 ! interspecies quorum sensing +relationship: part_of GO:0051701 ! interaction with host + +[Term] +id: GO:0052107 +name: positive regulation by symbiont of defense-related host callose deposition +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host callose deposition" NARROW [] +synonym: "induction by organism of defense-related host callose deposition" NARROW [] +synonym: "induction by organism of defense-related papilla formation in host" NARROW [] +synonym: "positive regulation by organism of defense-related papilla formation in host" EXACT [] +synonym: "stimulation by symbiont of defense-related host callose deposition" NARROW [] +synonym: "up regulation by symbiont of defense-related host callose deposition" EXACT [] +synonym: "up-regulation by symbiont of defense-related host callose deposition" EXACT [] +synonym: "upregulation by symbiont of defense-related host callose deposition" EXACT [] +is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition +is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0052108 +name: growth or development of symbiont during interaction with host +namespace: biological_process +def: "The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "growth or development of organism during interaction with host" EXACT [] +synonym: "growth or development of organism in response to host" EXACT [] +is_a: GO:0052171 ! growth or development during symbiotic interaction +relationship: part_of GO:0051701 ! interaction with host + +[Term] +id: GO:0052109 +name: positive regulation by symbiont of defense-related host cell wall callose deposition +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host cell wall callose deposition" NARROW [] +synonym: "induction by organism of defense-related host cell wall callose deposition" NARROW [] +synonym: "positive regulation by organism of defense-related host cell wall callose deposition" EXACT [] +synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" NARROW [] +synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +is_a: GO:0052107 ! positive regulation by symbiont of defense-related host callose deposition +is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition +is_a: GO:0052292 ! positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction +is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening + +[Term] +id: GO:0052110 +name: occlusion by symbiont of host vascular system +namespace: biological_process +def: "The process by which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] +subset: gosubset_prok +is_a: GO:0052111 ! modification by symbiont of host structure +is_a: GO:0052495 ! occlusion by organism of vascular system in other organism during symbiotic interaction + +[Term] +id: GO:0052111 +name: modification by symbiont of host structure +namespace: biological_process +def: "The process by which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction + +[Term] +id: GO:0052112 +name: occlusion by symbiont of host xylem +namespace: biological_process +def: "The process by which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052110 ! occlusion by symbiont of host vascular system +is_a: GO:0052497 ! occlusion by organism of xylem in other organism during symbiotic interaction + +[Term] +id: GO:0052113 +name: adaptation to host osmotic environment +namespace: biological_process +def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. +subset: gosubset_prok +synonym: "osmotic tolerance to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052114 +name: adaptation to host pH environment +namespace: biological_process +def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. +subset: gosubset_prok +synonym: "pH tolerance to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052115 +name: energy taxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "energy taxis in response to host environment" EXACT [] +is_a: GO:0052126 ! movement in host environment +is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052116 +name: chemotaxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "chemotaxis in response to host environment" EXACT [] +is_a: GO:0052126 ! movement in host environment +is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052117 +name: aerotaxis in host environment +namespace: biological_process +def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "aerotaxis in response to host environment" EXACT [] +is_a: GO:0052115 ! energy taxis in host environment +is_a: GO:0052116 ! chemotaxis in host environment +is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052118 +name: positive energy taxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "positive energy taxis in response to host environment" EXACT [] +is_a: GO:0052115 ! energy taxis in host environment +is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052119 +name: negative energy taxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "negative energy taxis in response to host environment" EXACT [] +is_a: GO:0052115 ! energy taxis in host environment +is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052120 +name: positive aerotaxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "positive aerotaxis in response to host environment" EXACT [] +is_a: GO:0052117 ! aerotaxis in host environment +is_a: GO:0052118 ! positive energy taxis in host environment +is_a: GO:0052121 ! positive chemotaxis in host environment +is_a: GO:0052220 ! positive aerotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052121 +name: positive chemotaxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "positive chemotaxis in response to host environment" EXACT [] +is_a: GO:0052116 ! chemotaxis in host environment +is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052122 +name: negative aerotaxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "negative aerotaxis in response to host environment" EXACT [] +is_a: GO:0052117 ! aerotaxis in host environment +is_a: GO:0052119 ! negative energy taxis in host environment +is_a: GO:0052123 ! negative chemotaxis in host environment +is_a: GO:0052222 ! negative aerotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052123 +name: negative chemotaxis in host environment +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "negative chemotaxis in response to host environment" EXACT [] +is_a: GO:0052116 ! chemotaxis in host environment +is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052124 +name: energy taxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044000 ! movement within host +is_a: GO:0052115 ! energy taxis in host environment +is_a: GO:0052224 ! energy taxis within other organism during symbiotic interaction + +[Term] +id: GO:0052125 +name: energy taxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052115 ! energy taxis in host environment +is_a: GO:0052127 ! movement on or near host +is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052126 +name: movement in host environment +namespace: biological_process +def: "The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "movement in response to host" EXACT [] +is_a: GO:0051701 ! interaction with host +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052127 +name: movement on or near host +namespace: biological_process +def: "The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052126 ! movement in host environment +is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction + +[Term] +id: GO:0052128 +name: positive energy taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0052129 +name: negative energy taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0052130 +name: negative aerotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] +is_a: GO:0009454 ! aerotaxis +is_a: GO:0050919 ! negative chemotaxis +is_a: GO:0052129 ! negative energy taxis + +[Term] +id: GO:0052131 +name: positive aerotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] +is_a: GO:0009454 ! aerotaxis +is_a: GO:0050918 ! positive chemotaxis +is_a: GO:0052128 ! positive energy taxis + +[Term] +id: GO:0052132 +name: positive aerotaxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052120 ! positive aerotaxis in host environment +is_a: GO:0052138 ! aerotaxis on or near host +is_a: GO:0052141 ! positive chemotaxis on or near host +is_a: GO:0052146 ! positive energy taxis on or near host +is_a: GO:0052232 ! positive aerotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052133 +name: positive aerotaxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052120 ! positive aerotaxis in host environment +is_a: GO:0052137 ! aerotaxis within host +is_a: GO:0052140 ! positive chemotaxis within host +is_a: GO:0052147 ! positive energy taxis within host +is_a: GO:0052233 ! positive aerotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052134 +name: negative aerotaxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052122 ! negative aerotaxis in host environment +is_a: GO:0052136 ! negative chemotaxis on or near host +is_a: GO:0052138 ! aerotaxis on or near host +is_a: GO:0052145 ! negative energy taxis on or near host +is_a: GO:0052234 ! negative aerotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052135 +name: negative aerotaxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052122 ! negative aerotaxis in host environment +is_a: GO:0052137 ! aerotaxis within host +is_a: GO:0052139 ! negative chemotaxis within host +is_a: GO:0052144 ! negative energy taxis within host +is_a: GO:0052235 ! negative aerotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052136 +name: negative chemotaxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052123 ! negative chemotaxis in host environment +is_a: GO:0052143 ! chemotaxis on or near host during symbiotic interaction +is_a: GO:0052236 ! negative chemotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052137 +name: aerotaxis within host +namespace: biological_process +def: "The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052117 ! aerotaxis in host environment +is_a: GO:0052124 ! energy taxis within host +is_a: GO:0052142 ! chemotaxis within host +is_a: GO:0052237 ! aerotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052138 +name: aerotaxis on or near host +namespace: biological_process +def: "The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052117 ! aerotaxis in host environment +is_a: GO:0052125 ! energy taxis on or near host +is_a: GO:0052143 ! chemotaxis on or near host during symbiotic interaction +is_a: GO:0052238 ! aerotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052139 +name: negative chemotaxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052123 ! negative chemotaxis in host environment +is_a: GO:0052142 ! chemotaxis within host +is_a: GO:0052239 ! negative chemotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052140 +name: positive chemotaxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052121 ! positive chemotaxis in host environment +is_a: GO:0052142 ! chemotaxis within host +is_a: GO:0052240 ! positive chemotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052141 +name: positive chemotaxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052121 ! positive chemotaxis in host environment +is_a: GO:0052143 ! chemotaxis on or near host during symbiotic interaction +is_a: GO:0052241 ! positive chemotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052142 +name: chemotaxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044000 ! movement within host +is_a: GO:0052116 ! chemotaxis in host environment +is_a: GO:0052242 ! chemotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052143 +name: chemotaxis on or near host during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052116 ! chemotaxis in host environment +is_a: GO:0052127 ! movement on or near host +is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052144 +name: negative energy taxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052119 ! negative energy taxis in host environment +is_a: GO:0052124 ! energy taxis within host + +[Term] +id: GO:0052145 +name: negative energy taxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052119 ! negative energy taxis in host environment +is_a: GO:0052125 ! energy taxis on or near host +is_a: GO:0052245 ! negative energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052146 +name: positive energy taxis on or near host +namespace: biological_process +def: "The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052118 ! positive energy taxis in host environment +is_a: GO:0052125 ! energy taxis on or near host +is_a: GO:0052246 ! positive energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052147 +name: positive energy taxis within host +namespace: biological_process +def: "The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052118 ! positive energy taxis in host environment +is_a: GO:0052124 ! energy taxis within host + +[Term] +id: GO:0052148 +name: modification by symbiont of host catalytic activity +namespace: biological_process +def: "The process by which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "modification by symbiont of host enzyme activity" EXACT [GOC:tb] +synonym: "modification of catalytic activity of host by symbiont" EXACT [] +synonym: "regulation by symbiont of host catalytic activity" EXACT [] +synonym: "regulation of catalytic activity of host by symbiont" EXACT [] +synonym: "regulation of host catalytic activity by symbiont" EXACT [] +is_a: GO:0052055 ! modification by symbiont of host molecular function +is_a: GO:0052203 ! modification of catalytic activity in other organism during symbiotic interaction + +[Term] +id: GO:0052149 +name: modification by symbiont of host protease activity +namespace: biological_process +def: "The process by which an organism effects a change in host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052148 ! modification by symbiont of host catalytic activity +is_a: GO:0052198 ! modification of protease activity in other organism during symbiotic interaction + +[Term] +id: GO:0052150 +name: modulation by symbiont of host apoptosis +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. +subset: gosubset_prok +synonym: "modulation by organism of host apoptotic programmed cell death" EXACT [] +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +is_a: GO:0052433 ! modulation by organism of apoptosis in other organism during symbiotic interaction + +[Term] +id: GO:0052151 +name: positive regulation by symbiont of host apoptosis +namespace: biological_process +alt_id: GO:0033669 +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'. +subset: gosubset_prok +synonym: "activation by symbiont of host apoptosis" NARROW [] +synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "stimulation by symbiont of host apoptosis" NARROW [] +synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "up regulation by symbiont of host apoptosis" EXACT [] +synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "up-regulation by symbiont of host apoptosis" EXACT [] +synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "upregulation by symbiont of host apoptosis" EXACT [] +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052150 ! modulation by symbiont of host apoptosis +is_a: GO:0052501 ! positive regulation by organism of apoptosis in other organism during symbiotic interaction + +[Term] +id: GO:0052152 +name: modulation by symbiont of host non-apoptotic programmed cell death +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by a non-apoptotic pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +is_a: GO:0052459 ! modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052153 +name: positive regulation by symbiont of host non-apoptotic programmed cell death +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by a non-apoptotic pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host non-apoptotic programmed cell death" NARROW [] +synonym: "stimulation by symbiont of host non-apoptotic programmed cell death" NARROW [] +synonym: "up regulation by symbiont of host non-apoptotic programmed cell death" EXACT [] +synonym: "up-regulation by symbiont of host non-apoptotic programmed cell death" EXACT [] +synonym: "upregulation by symbiont of host non-apoptotic programmed cell death" EXACT [] +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052152 ! modulation by symbiont of host non-apoptotic programmed cell death +is_a: GO:0052518 ! positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052154 +name: modulation by symbiont of host B-cell mediated immune response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "regulation by organism of host B-cell mediated immune response" EXACT [] +is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052155 +name: modulation by symbiont of host cell-mediated immune response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of host cell-based immune response" EXACT [] +is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052156 +name: modulation by symbiont of host T-cell mediated immune response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response +is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052157 +name: modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity +namespace: biological_process +subset: gosubset_prok +is_a: GO:0052167 ! modulation by symbiont of host innate immunity +is_a: GO:0052296 ! modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction + +[Term] +id: GO:0052158 +name: modulation by symbiont of host resistance gene-dependent defense response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense response in host by specific elicitors" EXACT [] +synonym: "modulation by organism of host gene-for-gene resistance" EXACT [] +synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] +is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052159 +name: modulation by symbiont of induced systemic resistance in host +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052160 +name: modulation by symbiont of systemic acquired resistance in host +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052161 +name: modulation by symbiont of defense-related host cell wall thickening +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of host defensive cell wall thickening" RELATED [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction + +[Term] +id: GO:0052162 +name: modulation by symbiont of defense-related host calcium ion flux +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction + +[Term] +id: GO:0052163 +name: modulation by symbiont of defense-related host nitric oxide production +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related host NO production" EXACT [] +is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response +is_a: GO:0052565 ! response to defense-related host nitric oxide production + +[Term] +id: GO:0052164 +name: modulation by symbiont of defense-related host reactive oxygen species production +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related host active oxygen species production" EXACT [] +synonym: "modulation by organism of defense-related host AOS production" EXACT [] +synonym: "modulation by organism of defense-related host metabolic burst" EXACT [] +synonym: "modulation by organism of defense-related host oxidative burst" EXACT [] +synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "modulation by organism of defense-related host respiratory burst" EXACT [] +synonym: "modulation by organism of defense-related host ROI production" EXACT [] +synonym: "modulation by organism of defense-related host ROS production" EXACT [] +is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response +is_a: GO:0052567 ! response to defense-related host reactive oxygen species production + +[Term] +id: GO:0052165 +name: modulation by symbiont of host phytoalexin production +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response +is_a: GO:0052566 ! response to host phytoalexin production + +[Term] +id: GO:0052166 +name: positive regulation by symbiont of host innate immunity +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host innate immunity" NARROW [] +synonym: "induction of host innate immune response" NARROW [] +synonym: "induction of host innate immunity" NARROW [] +synonym: "positive regulation of host innate immune response" EXACT [] +synonym: "stimulation by symbiont of host innate immunity" NARROW [] +synonym: "up regulation by symbiont of host innate immunity" EXACT [] +synonym: "up-regulation by symbiont of host innate immunity" EXACT [] +synonym: "upregulation by symbiont of host innate immunity" EXACT [] +is_a: GO:0052167 ! modulation by symbiont of host innate immunity +is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052167 +name: modulation by symbiont of host innate immunity +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of host innate immune response" EXACT [] +is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052168 +name: modulation by symbiont of defense-related host calcium-dependent protein kinase pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related host CDPK pathway" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052169 +name: pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity +namespace: biological_process +subset: gosubset_prok +is_a: GO:0052167 ! modulation by symbiont of host innate immunity +is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction + +[Term] +id: GO:0052170 +name: negative regulation by symbiont of host innate immunity +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host innate immunity" EXACT [] +synonym: "down-regulation by symbiont of host innate immunity" EXACT [] +synonym: "downregulation by symbiont of host innate immunity" EXACT [] +synonym: "inhibition by symbiont of host innate immunity" NARROW [] +synonym: "negative regulation of host innate immune response" EXACT [] +is_a: GO:0052167 ! modulation by symbiont of host innate immunity +is_a: GO:0052309 ! negative regulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052562 ! negative regulation by symbiont of host immune response + +[Term] +id: GO:0052171 +name: growth or development during symbiotic interaction +namespace: biological_process +def: "The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0052172 +name: metabolism by symbiont of host cell wall cellulose +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate +is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism during symbiotic interaction + +[Term] +id: GO:0052173 +name: response to defenses of other organism during symbiotic interaction +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0052174 +name: metabolism by symbiont of host macromolecule +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052002 ! metabolism by symbiont of substance in host +is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction + +[Term] +id: GO:0052175 +name: metabolism by symbiont of host carbohydrate +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052174 ! metabolism by symbiont of host macromolecule +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052176 +name: metabolism by symbiont of host glucan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate +is_a: GO:0052415 ! metabolism by organism of glucan in other organism during symbiotic interaction + +[Term] +id: GO:0052177 +name: metabolism by symbiont of host xylan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate +is_a: GO:0052421 ! metabolism by organism of xylan in other organism during symbiotic interaction + +[Term] +id: GO:0052178 +name: metabolism by symbiont of host cell wall chitin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate +is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism during symbiotic interaction + +[Term] +id: GO:0052179 +name: metabolism by symbiont of host cell wall pectin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate +is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism during symbiotic interaction + +[Term] +id: GO:0052180 +name: negative regulation of peptidase activity in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:0052198 ! modification of protease activity in other organism during symbiotic interaction +is_a: GO:0052199 ! negative regulation of catalytic activity in other organism during symbiotic interaction + +[Term] +id: GO:0052181 +name: modulation by host of symbiont defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052201 ! response to symbiont defenses +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052182 +name: modification by host of symbiont morphology or physiology via secreted substance +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction +is_a: GO:0052213 ! interaction with symbiont via secreted substance + +[Term] +id: GO:0052183 +name: modification by host of symbiont structure +namespace: biological_process +def: "The process by which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction + +[Term] +id: GO:0052184 +name: modulation by organism of symbiont hormone or growth regulator levels +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052185 +name: modification of structure of other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052186 +name: modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction +namespace: biological_process +def: "The alteration by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052187 +name: modification by host of symbiont cellular component +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052183 ! modification by host of symbiont structure +is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052188 +name: modification of cellular component in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction + +[Term] +id: GO:0052189 +name: modulation by symbiont of defense-related host cell wall callose deposition +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition +is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening +is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction + +[Term] +id: GO:0052190 +name: modulation by symbiont of host phagocytosis +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0044003 ! modification by symbiont of host morphology or physiology +is_a: GO:0052231 ! modulation of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052191 +name: positive regulation by symbiont of host phagocytosis +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host phagocytosis" NARROW [] +synonym: "stimulation by symbiont of host phagocytosis" NARROW [] +synonym: "up regulation by symbiont of host phagocytosis" EXACT [] +synonym: "up-regulation by symbiont of host phagocytosis" EXACT [] +synonym: "upregulation by symbiont of host phagocytosis" EXACT [] +is_a: GO:0052190 ! modulation by symbiont of host phagocytosis +is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052192 +name: movement in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "locomotion in environment of other organism during symbiotic interaction" EXACT [] +is_a: GO:0040011 ! locomotion +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0052193 +name: movement in symbiont environment +namespace: biological_process +def: "The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052194 +name: movement on or near symbiont +namespace: biological_process +def: "The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052193 ! movement in symbiont environment +is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction + +[Term] +id: GO:0052195 +name: movement on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052196 +name: negative regulation by host of symbiont defense response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by host of symbiont defense response" EXACT [] +synonym: "down-regulation by host of symbiont defense response" EXACT [] +synonym: "downregulation by host of symbiont defense response" EXACT [] +synonym: "inhibition by host of symbiont defense response" NARROW [] +is_a: GO:0051859 ! suppression of symbiont defenses +is_a: GO:0052181 ! modulation by host of symbiont defense response +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052197 +name: positive regulation by host of symbiont defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by host of symbiont defense response" NARROW [] +synonym: "stimulation by host of symbiont defense response" NARROW [] +synonym: "up regulation by host of symbiont defense response" EXACT [] +synonym: "up-regulation by host of symbiont defense response" EXACT [] +synonym: "upregulation by host of symbiont defense response" EXACT [] +is_a: GO:0052181 ! modulation by host of symbiont defense response +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052198 +name: modification of protease activity in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052203 ! modification of catalytic activity in other organism during symbiotic interaction + +[Term] +id: GO:0052199 +name: negative regulation of catalytic activity in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition of enzyme activity in other organism" EXACT [] +synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0052203 ! modification of catalytic activity in other organism during symbiotic interaction +is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0052200 +name: response to host defenses +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction + +[Term] +id: GO:0052201 +name: response to symbiont defenses +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction + +[Term] +id: GO:0052202 +name: negative regulation by symbiont of defense-related host cell wall callose deposition +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW [] +is_a: GO:0052087 ! negative regulation by symbiont of defense-related host callose deposition +is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition +is_a: GO:0052311 ! negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction + +[Term] +id: GO:0052203 +name: modification of catalytic activity in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "modification of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb] +is_a: GO:0050790 ! regulation of catalytic activity +is_a: GO:0052205 ! modification of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0052204 +name: negative regulation of molecular function in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition of protein function in other organism" EXACT [] +synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052205 ! modification of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0052205 +name: modification of molecular function in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +subset: gosubset_prok +synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052206 +name: modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system during symbiotic interaction +is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052207 +name: modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system during symbiotic interaction +is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052208 +name: modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction +is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052209 +name: interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction +namespace: biological_process +def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052210 +name: interaction with other organism via protein secreted by type III secretion system during symbiotic interaction +namespace: biological_process +def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052211 +name: interaction with other organism via protein secreted by type II secretion system during symbiotic interaction +namespace: biological_process +def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052212 +name: modification of morphology or physiology of other organism via secreted substance during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modification of host morphology or physiology via effector molecule" NARROW [] +synonym: "modification of host morphology or physiology via ellicitor" NARROW [] +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction +is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052213 +name: interaction with symbiont via secreted substance +namespace: biological_process +def: "An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051702 ! interaction with symbiont +is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction + +[Term] +id: GO:0052214 +name: metabolism of substance in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052215 +name: energy taxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "energy taxis in response to environment of other organism" EXACT [] +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052216 +name: chemotaxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "chemotaxis in response to environment of other organism" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052217 +name: aerotaxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "aerotaxis in response to environment of other organism" EXACT [] +is_a: GO:0009454 ! aerotaxis +is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052218 +name: positive energy taxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "positive energy taxis in response to environment of other organism" EXACT [] +is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052219 +name: negative energy taxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "negative energy taxis in response to environment of other organism" EXACT [] +is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052220 +name: positive aerotaxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "positive aerotaxis in response to environment of other organism" EXACT [] +is_a: GO:0052131 ! positive aerotaxis +is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052221 +name: positive chemotaxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "positive chemotaxis in response to environment of other organism" EXACT [] +is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052222 +name: negative aerotaxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "negative aerotaxis in response to environment of other organism" EXACT [] +is_a: GO:0052130 ! negative aerotaxis +is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052223 +name: negative chemotaxis in environment of other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "negative chemotaxis in response to environment of other organism" EXACT [] +is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052224 +name: energy taxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051814 ! movement within other organism during symbiotic interaction +is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052225 +name: energy taxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction +is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052226 +name: biosynthesis of substance in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052227 +name: catabolism of substance in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052228 +name: metabolism by symbiont of host protein +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052174 ! metabolism by symbiont of host macromolecule +is_a: GO:0052418 ! metabolism by organism of protein in other organism during symbiotic interaction + +[Term] +id: GO:0052229 +name: metabolism of macromolecule in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052230 +name: modulation of intracellular transport in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of intracellular trafficking in other organism" EXACT [] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052231 +name: modulation of phagocytosis in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0050764 ! regulation of phagocytosis +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052232 +name: positive aerotaxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052220 ! positive aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052238 ! aerotaxis on or near other organism during symbiotic interaction +is_a: GO:0052241 ! positive chemotaxis on or near other organism during symbiotic interaction +is_a: GO:0052246 ! positive energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052233 +name: positive aerotaxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052220 ! positive aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052237 ! aerotaxis within other organism during symbiotic interaction +is_a: GO:0052240 ! positive chemotaxis within other organism during symbiotic interaction +is_a: GO:0052247 ! positive energy taxis within other organism during symbiotic interaction + +[Term] +id: GO:0052234 +name: negative aerotaxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052222 ! negative aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052236 ! negative chemotaxis on or near other organism during symbiotic interaction +is_a: GO:0052238 ! aerotaxis on or near other organism during symbiotic interaction +is_a: GO:0052245 ! negative energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052235 +name: negative aerotaxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052222 ! negative aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052237 ! aerotaxis within other organism during symbiotic interaction +is_a: GO:0052239 ! negative chemotaxis within other organism during symbiotic interaction +is_a: GO:0052244 ! negative energy taxis within other organism during symbiotic interaction + +[Term] +id: GO:0052236 +name: negative chemotaxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052237 +name: aerotaxis within other organism during symbiotic interaction +namespace: biological_process +def: "The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052224 ! energy taxis within other organism during symbiotic interaction +is_a: GO:0052242 ! chemotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052238 +name: aerotaxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction +is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052239 +name: negative chemotaxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052242 ! chemotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052240 +name: positive chemotaxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052242 ! chemotaxis within other organism during symbiotic interaction + +[Term] +id: GO:0052241 +name: positive chemotaxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction +is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052242 +name: chemotaxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051814 ! movement within other organism during symbiotic interaction +is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052243 +name: chemotaxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction +is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction + +[Term] +id: GO:0052244 +name: negative energy taxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052224 ! energy taxis within other organism during symbiotic interaction + +[Term] +id: GO:0052245 +name: negative energy taxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052246 +name: positive energy taxis on or near other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction + +[Term] +id: GO:0052247 +name: positive energy taxis within other organism during symbiotic interaction +namespace: biological_process +def: "The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction +is_a: GO:0052224 ! energy taxis within other organism during symbiotic interaction + +[Term] +id: GO:0052248 +name: modulation of programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052249 +name: modulation of RNA levels in other organism during symbiotic interaction +namespace: biological_process +def: "The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052250 +name: modulation of signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, occurring in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052251 +name: induction by organism of defense response of other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +subset: gosubset_prok +synonym: "activation of defense response of other organism" EXACT [] +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052252 +name: negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" NARROW [] +synonym: "negative modulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] +synonym: "negative modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" EXACT [] +synonym: "negative regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] +is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052253 +name: negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of SA-mediated defense response of other organism" EXACT [] +synonym: "suppression by organism of salicylic acid-mediated defense response of other organism" EXACT [] +synonym: "suppression of SA mediated defense response of other organism" EXACT [] +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052254 +name: negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "suppression by organism of ethylene-mediated defense response of other organism" EXACT [] +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052255 +name: modulation by organism of defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the defense response of a second organism, the response mounted by that organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction +is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction + +[Term] +id: GO:0052256 +name: modulation by organism of inflammatory response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0050727 ! regulation of inflammatory response +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052257 +name: pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction +namespace: biological_process +subset: gosubset_prok +synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT [] +synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT [] +synonym: "MAMP dependent induction of innate immunity of other organism" EXACT [] +synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT [] +synonym: "PAMP dependent induction of innate immunity of other organism" EXACT [] +synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT [] +is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction + +[Term] +id: GO:0052258 +name: negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction +namespace: biological_process +subset: gosubset_prok +synonym: "down regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" NARROW [] +synonym: "suppression of general elicitor induced innate immunity of other organism" EXACT [] +synonym: "suppression of general elicitor-induced innate immunity of other organism" EXACT [] +synonym: "suppression of MAMP induced innate immunity of other organism" EXACT [] +synonym: "suppression of MAMP-induced innate immunity of other organism" EXACT [] +synonym: "suppression of PAMP induced innate immunity of other organism" EXACT [] +synonym: "suppression of PAMP-induced innate immunity of other organism" EXACT [] +synonym: "suppression of pathogen-associated molecular pattern-induced innate immunity of other organism" EXACT [] +is_a: GO:0052296 ! modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction +is_a: GO:0052309 ! negative regulation by organism of innate immunity in other organism during symbiotic interaction + +[Term] +id: GO:0052259 +name: positive regulation by organism of inflammatory response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of inflammatory response of other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of inflammatory response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052260 +name: negative regulation by organism of inflammatory response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of inflammatory response of other organism during symbiotic interaction" NARROW [] +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism during symbiotic interaction +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052261 +name: negative regulation by organism of defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW [] +synonym: "suppression of defense response of other organism" EXACT [] +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0051833 ! suppression of defenses of other organism during symbiotic interaction +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052262 +name: induction by organism of phytoalexin production in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism during symbiotic interaction +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052263 +name: induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related nitric oxide production in other organism" EXACT [] +synonym: "activation by organism of defense-related NO production in other organism" EXACT [] +synonym: "induction by organism of defense-related NO production in other organism" EXACT [] +is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction + +[Term] +id: GO:0052264 +name: induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related active oxygen species production in other organism" EXACT [] +synonym: "activation by organism of defense-related AOS production in other organism" EXACT [] +synonym: "activation by organism of defense-related metabolic burst in other organism" EXACT [] +synonym: "activation by organism of defense-related oxidative burst in other organism" EXACT [] +synonym: "activation by organism of defense-related reactive oxidative species production in other organism" EXACT [] +synonym: "activation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] +synonym: "activation by organism of defense-related reactive oxygen species production in other organism" EXACT [] +synonym: "activation by organism of defense-related respiratory burst in other organism" EXACT [] +synonym: "activation by organism of defense-related ROI production in other organism" EXACT [] +synonym: "activation by organism of defense-related ROS production in other organism" EXACT [] +synonym: "induction by organism of defense-related active oxygen species production in other organism" EXACT [] +synonym: "induction by organism of defense-related AOS production in other organism" EXACT [] +synonym: "induction by organism of defense-related metabolic burst in other organism" EXACT [] +synonym: "induction by organism of defense-related oxidative burst in other organism" EXACT [] +synonym: "induction by organism of defense-related reactive oxidative species production in other organism" EXACT [] +synonym: "induction by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] +synonym: "induction by organism of defense-related respiratory burst in other organism" EXACT [] +synonym: "induction by organism of defense-related ROI production in other organism" EXACT [] +synonym: "induction by organism of defense-related ROS production in other organism" EXACT [] +is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052265 +name: induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of Ca2+ flux of other organism" EXACT [] +synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT [] +synonym: "induction by organism of Ca2+ flux of other organism" EXACT [] +is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction +is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052266 +name: negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "suppression by organism of JA-mediated defense response of other organism" EXACT [] +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052267 +name: negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation by organism of defense-related JA-mediated signal transduction pathway in other organism" EXACT [] +is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052268 +name: negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052269 +name: positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] +synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] +synonym: "stimulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] +synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052270 +name: positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW [] +synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +synonym: "induction by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW [] +synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +synonym: "stimulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW [] +synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052271 +name: positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW [] +synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +synonym: "induction by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW [] +synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] +synonym: "stimulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW [] +synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW [] +is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052272 +name: positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of SA-mediated defense response of other organism" NARROW [] +synonym: "induction by organism of salicylic acid-mediated defense response of other organism" NARROW [] +synonym: "positive regulation by organism of SA-mediated defense response of other organism" EXACT [] +synonym: "stimulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052273 +name: positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of JA-mediated defense response of other organism" NARROW [] +synonym: "induction by organism of jasmonic acid-mediated defense response of other organism" NARROW [] +synonym: "positive regulation by organism of JA-mediated defense response of other organism" EXACT [] +synonym: "stimulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052274 +name: positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of ethylene-mediated defense response of other organism" NARROW [] +synonym: "activation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of ethylene-mediated defense response of other organism" NARROW [] +synonym: "stimulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of ethylene-mediated defense response of other organism" NARROW [] +synonym: "upregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052275 +name: negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT [] +synonym: "negative regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT [] +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052276 +name: positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] +synonym: "activation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] +synonym: "positive regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT [] +synonym: "stimulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW [] +synonym: "upregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052277 +name: modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of defense-related MAPK-mediated signal transduction pathway of other organism" EXACT [] +synonym: "modulation of defense-related mitogen activated protein kinase-mediated signal transduction pathway of other organism" EXACT [] +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052278 +name: negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of cell-mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of cell-mediated immune response of other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation by organism of cell-based immune response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism during symbiotic interaction +is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052279 +name: modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052280 +name: negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of T-cell mediated immune response of other organism during symbiotic interaction" NARROW [] +is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction +is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052281 +name: negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of B-cell mediated immune response of other organism during symbiotic interaction" NARROW [] +is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction +is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052282 +name: negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW [] +synonym: "suppression by organism of defense-related callose deposition of other organism" EXACT [] +is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction + +[Term] +id: GO:0052283 +name: modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of JA-mediated defense response of other organism" EXACT [] +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052284 +name: modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of SA-mediated defense response of other organism" EXACT [] +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052285 +name: modulation by organism of defense-related callose deposition of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052286 +name: induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense response of other organism by specific elicitors" EXACT [] +synonym: "activation by organism of gene-for-gene resistance in other organism" EXACT [] +synonym: "activation by organism of resistance gene-dependent defense response of other organism" EXACT [] +synonym: "induction by organism of defense response of other organism by specific elicitors" EXACT [] +synonym: "induction by organism of gene-for-gene resistance in other organism" EXACT [] +is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052287 +name: positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of calcium-dependent protein kinase pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of defense-related CDPK pathway of other organism" EXACT [] +synonym: "stimulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052288 +name: induction by organism of induced systemic resistance in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT [] +synonym: "activation by organism of ISR in other organism" EXACT [] +synonym: "induction by organism of ISR in other organism" EXACT [] +is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052289 +name: induction by organism of systemic acquired resistance in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of SAR in other organism" EXACT [] +synonym: "activation by organism of systemic acquired resistance in other organism" EXACT [] +synonym: "induction by organism of SAR in other organism" EXACT [] +is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052290 +name: induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT [] +synonym: "activation by organism of defensive cell wall thickening in other organism during symbiotic interaction" EXACT [] +synonym: "induction by organism of defensive cell wall thickening in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction + +[Term] +id: GO:0052291 +name: positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of defense-related callose deposition of other organism" NARROW [] +synonym: "induction by organism of defense-related papilla formation in other organism" NARROW [] +synonym: "positive regulation by organism of defense-related papilla formation in other organism" EXACT [] +synonym: "stimulation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052292 +name: positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition by a second organism of callose in its cell walls, occurring as part of the defense response, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of defense-related cell wall callose deposition in other organism" NARROW [] +synonym: "stimulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction +is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction +is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction + +[Term] +id: GO:0052293 +name: modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "regulation by organism of B-cell mediated immune response of other organism" EXACT [] +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052294 +name: modulation by organism of cell-mediated immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of cell-based immune response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052295 +name: modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052296 +name: modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction +namespace: biological_process +is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction + +[Term] +id: GO:0052297 +name: modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense response in other organism by specific elicitors" EXACT [] +synonym: "modulation by organism of gene-for-gene resistance in other organism" EXACT [] +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052298 +name: modulation by organism of induced systemic resistance in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052299 +name: modulation by organism of systemic acquired resistance in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0010112 ! regulation of systemic acquired resistance +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052300 +name: modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED [] +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052301 +name: modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052302 +name: modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related NO production in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism during symbiotic interaction +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052303 +name: modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related active oxygen species production in other organism" EXACT [] +synonym: "modulation by organism of defense-related AOS production in other organism" EXACT [] +synonym: "modulation by organism of defense-related metabolic burst in other organism" EXACT [] +synonym: "modulation by organism of defense-related oxidative burst in other organism" EXACT [] +synonym: "modulation by organism of defense-related reactive oxidative species production in other organism" EXACT [] +synonym: "modulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] +synonym: "modulation by organism of defense-related respiratory burst in other organism" EXACT [] +synonym: "modulation by organism of defense-related ROI production in other organism" EXACT [] +synonym: "modulation by organism of defense-related ROS production in other organism" EXACT [] +is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism during symbiotic interaction +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052304 +name: modulation by organism of phytoalexin production in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052549 ! response to phytoalexin production by other organism during symbiotic interaction +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052305 +name: positive regulation by organism of innate immunity in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of innate immunity in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation of innate immune response of other organism" EXACT [] +synonym: "stimulation by organism of innate immunity in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052306 +name: modulation by organism of innate immunity in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of innate immune response of other organism" EXACT [] +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052307 +name: modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of calcium-dependent protein kinase signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of defense-related CDPK pathway in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052308 +name: pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction +namespace: biological_process +is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction + +[Term] +id: GO:0052309 +name: negative regulation by organism of innate immunity in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of innate immunity in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of innate immune response of other organism" EXACT [] +is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052310 +name: modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction +is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction + +[Term] +id: GO:0052311 +name: negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW [] +is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction + +[Term] +id: GO:0052312 +name: modulation of transcription in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0045449 ! regulation of transcription +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0052313 +name: modulation of nutrient release from other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction +relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction + +[Term] +id: GO:0052314 +name: phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [http://en.wikipedia.org "Wikipedia"] +subset: goslim_pir +subset: gosubset_prok +synonym: "phytoalexin metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0052315 +name: phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [http://en.wikipedia.org "Wikipedia"] +synonym: "phytoalexin biosynthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052316 +name: phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] +synonym: "phytoalexin catabolism" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052317 +name: camalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai] +synonym: "camalexin metabolism" EXACT [] +is_a: GO:0046217 ! indole phytoalexin metabolic process + +[Term] +id: GO:0052318 +name: regulation of phytoalexin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] +synonym: "regulation of phytoalexin metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052319 +name: regulation of phytoalexin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] +synonym: "regulation of phytoalexin biosynthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0052318 ! regulation of phytoalexin metabolic process +relationship: regulates GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0052320 +name: positive regulation of phytoalexin metabolic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06] +synonym: "activation of phytoalexin metabolism" NARROW [] +synonym: "positive regulation of phytoalexin metabolism" RELATED [] +synonym: "stimulation of phytoalexin metabolism" NARROW [] +synonym: "up regulation of phytoalexin metabolism" EXACT [] +synonym: "up-regulation of phytoalexin metabolism" EXACT [] +synonym: "upregulation of phytoalexin metabolism" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0052318 ! regulation of phytoalexin metabolic process +relationship: positively_regulates GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052321 +name: negative regulation of phytoalexin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai] +synonym: "down regulation of phytoalexin metabolism" EXACT [] +synonym: "down-regulation of phytoalexin metabolism" EXACT [] +synonym: "downregulation of phytoalexin metabolism" EXACT [] +synonym: "inhibition of phytoalexin metabolism" NARROW [] +synonym: "negative regulation of phytoalexin metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0052318 ! regulation of phytoalexin metabolic process +relationship: negatively_regulates GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052322 +name: positive regulation of phytoalexin biosynthetic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06] +synonym: "activation of phytoalexin biosynthesis" NARROW [] +synonym: "positive regulation of phytoalexin biosynthesis" EXACT [] +synonym: "stimulation of phytoalexin biosynthesis" NARROW [] +synonym: "up regulation of phytoalexin biosynthesis" EXACT [] +synonym: "up-regulation of phytoalexin biosynthesis" EXACT [] +synonym: "upregulation of phytoalexin biosynthesis" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process +is_a: GO:0052320 ! positive regulation of phytoalexin metabolic process +relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0052323 +name: negative regulation of phytoalexin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] +synonym: "down regulation of phytoalexin biosynthesis" EXACT [] +synonym: "down-regulation of phytoalexin biosynthesis" EXACT [] +synonym: "downregulation of phytoalexin biosynthesis" EXACT [] +synonym: "inhibition of phytoalexin biosynthesis" NARROW [] +synonym: "negative regulation of phytoalexin biosynthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process +is_a: GO:0052321 ! negative regulation of phytoalexin metabolic process +relationship: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0052324 +name: cell wall cellulose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai] +synonym: "cell wall cellulose biosynthesis" EXACT [] +synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED [] +is_a: GO:0030244 ! cellulose biosynthetic process +is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process +relationship: part_of GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0052325 +name: cell wall pectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] +synonym: "cell wall pectin biosynthesis" EXACT [] +synonym: "pectin biosynthesis during cell wall organization and biogenesis" EXACT [] +is_a: GO:0045489 ! pectin biosynthetic process +is_a: GO:0052546 ! cell wall pectin metabolic process +relationship: part_of GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0052326 +name: interaction with symbiont via protein secreted by type IV secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052327 +name: interaction with symbiont via protein secreted by type II secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052328 +name: interaction with symbiont via protein secreted by type III secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052329 +name: positive regulation by organism of phytoalexin production in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052330 +name: positive regulation by organism of programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] +is_a: GO:0051712 ! positive regulation of killing of cells of another organism +is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction +relationship: positively_regulates GO:0051883 ! killing of cells in other organism during symbiotic interaction + +[Term] +id: GO:0052331 +name: hemolysis by organism of red blood cells in other organism during symbiotic interaction +namespace: biological_process +def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, SP_KW:KW-0354] +subset: gosubset_prok +synonym: "haemolysis in other organism" EXACT [] +synonym: "hemolysin activity" RELATED [] +is_a: GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction + +[Term] +id: GO:0052332 +name: modification by organism of cell membrane in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the cell membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052333 +name: modification by organism of cell wall of other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "metabolism by organism of cell wall of other organism" RELATED [] +is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052334 +name: modification by organism of cytoskeleton in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052335 +name: modification by host of symbiont cytoskeleton +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052187 ! modification by host of symbiont cellular component +is_a: GO:0052334 ! modification by organism of cytoskeleton in other organism during symbiotic interaction + +[Term] +id: GO:0052336 +name: modification by host of symbiont cell wall +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "metabolism of symbiont cell wall by organism" EXACT [] +is_a: GO:0052187 ! modification by host of symbiont cellular component +is_a: GO:0052333 ! modification by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052337 +name: modification by host of symbiont cell membrane +namespace: biological_process +def: "The process by which an organism effects a change in the structure or function of the symbiont cell membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052187 ! modification by host of symbiont cellular component +is_a: GO:0052332 ! modification by organism of cell membrane in other organism during symbiotic interaction + +[Term] +id: GO:0052338 +name: disassembly by host of symbiont cell wall +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism of symbiont cell wall by organism" EXACT [] +synonym: "degradation of symbiont cell wall by organism" EXACT [] +is_a: GO:0052336 ! modification by host of symbiont cell wall +is_a: GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction +is_a: GO:0052367 ! disassembly by host of symbiont cellular component + +[Term] +id: GO:0052339 +name: disassembly by organism of cell wall of other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052333 ! modification by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052340 +name: catabolism by organism of cell wall cellulose in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism during symbiotic interaction +relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052341 +name: catabolism by organism of cell wall pectin in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism during symbiotic interaction +relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052342 +name: catabolism by organism of cell wall chitin in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism during symbiotic interaction +relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction + +[Term] +id: GO:0052343 +name: positive regulation by organism of symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052344 +name: positive regulation by symbiont of host phytoalexin production +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host phytoalexin production" NARROW [] +synonym: "stimulation by symbiont of host phytoalexin production" NARROW [] +synonym: "up regulation by symbiont of host phytoalexin production" EXACT [] +synonym: "up-regulation by symbiont of host phytoalexin production" EXACT [] +synonym: "upregulation by symbiont of host phytoalexin production" EXACT [] +is_a: GO:0052165 ! modulation by symbiont of host phytoalexin production +is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052345 +name: positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of defense-related NO production in other organism during symbiotic interaction" EXACT [] +synonym: "stimulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052346 +name: positive regulation by organism of defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052347 +name: positive regulation by symbiont of defense-related host nitric oxide production +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host nitric oxide production" NARROW [] +synonym: "positive regulation by organism of defense-related host NO production" EXACT [] +synonym: "stimulation by symbiont of defense-related host nitric oxide production" NARROW [] +synonym: "up regulation by symbiont of defense-related host nitric oxide production" EXACT [] +synonym: "up-regulation by symbiont of defense-related host nitric oxide production" EXACT [] +synonym: "upregulation by symbiont of defense-related host nitric oxide production" EXACT [] +is_a: GO:0052163 ! modulation by symbiont of defense-related host nitric oxide production +is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052348 +name: positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of defense-related active oxygen species production in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related AOS production in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related metabolic burst in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related oxidative burst in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related reactive oxidative species production in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related respiratory burst in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related ROI production in other organism" EXACT [] +synonym: "positive regulation by organism of defense-related ROS production in other organism" EXACT [] +synonym: "stimulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052349 +name: positive regulation by organism of defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052350 +name: induction by organism of induced systemic resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of induced systemic resistance in symbiont" EXACT [] +synonym: "activation by organism of ISR in symbiont" EXACT [] +synonym: "induction by organism of ISR in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052351 +name: induction by organism of systemic acquired resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of SAR in symbiont" EXACT [] +synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT [] +synonym: "induction by organism of SAR in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052352 +name: biosynthesis by host of substance in symbiont +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052226 ! biosynthesis of substance in other organism during symbiotic interaction +is_a: GO:0052419 ! metabolism by host of substance in symbiont + +[Term] +id: GO:0052353 +name: catabolism by host of symbiont carbohydrate +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052360 ! catabolism by host of symbiont macromolecule +is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate + +[Term] +id: GO:0052354 +name: catabolism by organism of carbohydrate in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052355 +name: catabolism by host of symbiont cell wall cellulose +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism during symbiotic interaction +is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate +is_a: GO:0052408 ! metabolism by host of symbiont cell wall cellulose +relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall + +[Term] +id: GO:0052356 +name: catabolism by host of symbiont cell wall chitin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism during symbiotic interaction +is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate +is_a: GO:0052410 ! metabolism by host of symbiont cell wall chitin +relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall + +[Term] +id: GO:0052357 +name: catabolism by host of symbiont cell wall pectin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism during symbiotic interaction +is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate +is_a: GO:0052412 ! metabolism by host of symbiont cell wall pectin +relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall + +[Term] +id: GO:0052358 +name: catabolism by host of symbiont glucan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate +is_a: GO:0052359 ! catabolism by organism of glucan in other organism during symbiotic interaction +is_a: GO:0052414 ! metabolism by host of symbiont glucan + +[Term] +id: GO:0052359 +name: catabolism by organism of glucan in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052415 ! metabolism by organism of glucan in other organism during symbiotic interaction + +[Term] +id: GO:0052360 +name: catabolism by host of symbiont macromolecule +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction +is_a: GO:0052364 ! catabolism by host of substance in symbiont +is_a: GO:0052416 ! metabolism by host of symbiont macromolecule + +[Term] +id: GO:0052361 +name: catabolism by organism of macromolecule in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052227 ! catabolism of substance in other organism during symbiotic interaction +is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction + +[Term] +id: GO:0052362 +name: catabolism by host of symbiont protein +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052360 ! catabolism by host of symbiont macromolecule +is_a: GO:0052363 ! catabolism by organism of protein in other organism during symbiotic interaction +is_a: GO:0052417 ! metabolism by host of symbiont protein + +[Term] +id: GO:0052363 +name: catabolism by organism of protein in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction +is_a: GO:0052418 ! metabolism by organism of protein in other organism during symbiotic interaction + +[Term] +id: GO:0052364 +name: catabolism by host of substance in symbiont +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052227 ! catabolism of substance in other organism during symbiotic interaction +is_a: GO:0052419 ! metabolism by host of substance in symbiont + +[Term] +id: GO:0052365 +name: catabolism by host of symbiont xylan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate +is_a: GO:0052366 ! catabolism by organism of xylan in other organism during symbiotic interaction +is_a: GO:0052420 ! metabolism by host of symbiont xylan + +[Term] +id: GO:0052366 +name: catabolism by organism of xylan in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052421 ! metabolism by organism of xylan in other organism during symbiotic interaction + +[Term] +id: GO:0052367 +name: disassembly by host of symbiont cellular component +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism of symbiont cellular component by organism" EXACT [] +synonym: "catabolism of symbiont structural constituent by organism" EXACT [] +synonym: "degradation of symbiont cellular component by organism" EXACT [] +is_a: GO:0052187 ! modification by host of symbiont cellular component +is_a: GO:0052368 ! disassembly by organism of cellular component in other organism during symbiotic interaction + +[Term] +id: GO:0052368 +name: disassembly by organism of cellular component in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +subset: gosubset_prok +synonym: "catabolism of cellular component in other organism" EXACT [] +synonym: "catabolism of structural constituent in other organism" EXACT [] +synonym: "degradation of cellular component in other organism" EXACT [] +is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction + +[Term] +id: GO:0052369 +name: positive regulation by symbiont of defense-related host reactive oxygen species production +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host reactive oxygen species production" NARROW [] +synonym: "positive regulation by organism of defense-related host active oxygen species production" EXACT [] +synonym: "positive regulation by organism of defense-related host AOS production" EXACT [] +synonym: "positive regulation by organism of defense-related host metabolic burst" EXACT [] +synonym: "positive regulation by organism of defense-related host oxidative burst" EXACT [] +synonym: "positive regulation by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "positive regulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "positive regulation by organism of defense-related host respiratory burst" EXACT [] +synonym: "positive regulation by organism of defense-related host ROI production" EXACT [] +synonym: "positive regulation by organism of defense-related host ROS production" EXACT [] +synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" NARROW [] +synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" EXACT [] +synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" EXACT [] +synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" EXACT [] +is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production +is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052370 +name: entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction +namespace: biological_process +def: "The invasion by an organism of a cell of a second organism by utilizing the second organism's phagocytosis mechanism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051806 ! entry into cell of other organism during symbiotic interaction +is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052371 +name: regulation by organism of entry into other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of entry into other organism during symbiotic interaction" EXACT [] +is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism +relationship: part_of GO:0051828 ! entry into other organism during symbiotic interaction + +[Term] +id: GO:0052372 +name: modulation by symbiont of entry into host +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction + +[Term] +id: GO:0052373 +name: negative regulation by organism of entry into other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by organism of entry into other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of entry into other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW [] +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction + +[Term] +id: GO:0052374 +name: negative regulation by symbiont of entry into host +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of entry into host" EXACT [] +synonym: "down-regulation by symbiont of entry into host" EXACT [] +synonym: "downregulation by symbiont of entry into host" EXACT [] +synonym: "inhibition by symbiont of entry into host" NARROW [] +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:0052373 ! negative regulation by organism of entry into other organism during symbiotic interaction + +[Term] +id: GO:0052375 +name: evasion or tolerance by organism of symbiont-produced nitric oxide +namespace: biological_process +def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of symbiont NO" EXACT [] +synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT [] +synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT [] +synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052376 +name: evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism avoids the effects of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion or tolerance by organism of NO produced by other organism during symbiotic interaction" EXACT [] +synonym: "evasion or tolerance by organism of other organism-produced nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of other organism-produced NO" EXACT [] +is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction +is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism during symbiotic interaction + +[Term] +id: GO:0052377 +name: evasion or tolerance by organism of symbiont-produced phytoalexins +namespace: biological_process +def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT [] +synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT [] +synonym: "symbiont phytoalexin detoxification" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052378 +name: evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism avoids the effects of phytoalexins produced as a defense response by the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion or tolerance of other organism phytoalexins" EXACT [] +synonym: "evasion or tolerance of phytoalexins produced by other organism" EXACT [] +synonym: "phytoalexin detoxification" NARROW [] +is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction +is_a: GO:0052549 ! response to phytoalexin production by other organism during symbiotic interaction + +[Term] +id: GO:0052379 +name: modulation by organism of entry into other organism via phagocytosis during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" EXACT [] +is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction + +[Term] +id: GO:0052380 +name: modulation by symbiont of entry into host via phagocytosis +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into the host, via the phagocytotic processes of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of entry into host via host phagocytosis" EXACT [] +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis during symbiotic interaction + +[Term] +id: GO:0052382 +name: induction by organism of innate immunity in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of innate immune response in other organism during symbiotic interaction" EXACT [] +synonym: "activation by organism of innate immunity in other organism during symbiotic interaction" EXACT [] +synonym: "induction by organism of innate immune response in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052383 +name: induction by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont innate immune response" EXACT [] +synonym: "activation by organism of symbiont innate immunity" EXACT [] +synonym: "induction by organism of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052384 +name: evasion or tolerance by organism of symbiont-produced reactive oxygen species +namespace: biological_process +def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW [] +synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT [] +synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT [] +synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT [] +synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT [] +synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT [] +synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT [] +synonym: "evasion or tolerance of symbiont-produced AOS" EXACT [] +synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT [] +synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT [] +synonym: "evasion or tolerance of symbiont-produced ROS" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052385 +name: evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion by organism of cellular damage caused by oxidative burst of other organism" NARROW [] +synonym: "evasion or tolerance by organism of defense-related metabolic burst in other organism during symbiotic interaction" EXACT [] +synonym: "evasion or tolerance by organism of defense-related oxidative burst in other organism during symbiotic interaction" EXACT [] +synonym: "evasion or tolerance by organism of defense-related respiratory burst in other organism during symbiotic interaction" EXACT [] +synonym: "evasion or tolerance by organism of reactive oxygen species produced during defense response of other organism" EXACT [] +synonym: "evasion or tolerance of active oxygen species produced by other organism" EXACT [] +synonym: "evasion or tolerance of AOS produced by other organism" EXACT [] +synonym: "evasion or tolerance of reactive oxygen intermediates produced by other organism" EXACT [] +synonym: "evasion or tolerance of reactive oxygen species produced by other organism" EXACT [] +synonym: "evasion or tolerance of ROIs produced by other organism" EXACT [] +synonym: "evasion or tolerance of ROS produced by other organism" EXACT [] +is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction +is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism during symbiotic interaction + +[Term] +id: GO:0052386 +name: cell wall thickening +namespace: biological_process +def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06] +is_a: GO:0042545 ! cell wall modification + +[Term] +id: GO:0052387 +name: induction by organism of symbiont apoptosis +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont apoptosis" EXACT [] +synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT [] +synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052388 +name: induction by organism of apoptosis in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" EXACT [] +synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "induction by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052400 ! induction by organism of programmed cell death in other organism during symbiotic interaction +is_a: GO:0052501 ! positive regulation by organism of apoptosis in other organism during symbiotic interaction + +[Term] +id: GO:0052389 +name: positive regulation by symbiont of defense-related host calcium ion flux +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host calcium ion flux" NARROW [] +synonym: "positive regulation by organism of defense-related host Ca2+ flux" EXACT [] +synonym: "stimulation by symbiont of defense-related host calcium ion flux" NARROW [] +synonym: "up regulation by symbiont of defense-related host calcium ion flux" EXACT [] +synonym: "up-regulation by symbiont of defense-related host calcium ion flux" EXACT [] +synonym: "upregulation by symbiont of defense-related host calcium ion flux" EXACT [] +is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction +is_a: GO:0052162 ! modulation by symbiont of defense-related host calcium ion flux +is_a: GO:0052509 ! positive regulation by symbiont of host defense response + +[Term] +id: GO:0052390 +name: induction by symbiont of host innate immunity +namespace: biological_process +def: "The activation by an organism of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of host innate immune response" EXACT [] +synonym: "activation by organism of host innate immunity" EXACT [] +synonym: "induction by organism of host innate immune response" RELATED [] +is_a: GO:0052166 ! positive regulation by symbiont of host innate immunity +is_a: GO:0052382 ! induction by organism of innate immunity in other organism during symbiotic interaction +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052391 +name: induction by symbiont of defense-related host calcium ion flux +namespace: biological_process +def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of host Ca2+ flux" EXACT [] +synonym: "activation by organism of host calcium ion flux" EXACT [] +synonym: "induction by organism of host Ca2+ flux" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052265 ! induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction +is_a: GO:0052389 ! positive regulation by symbiont of defense-related host calcium ion flux + +[Term] +id: GO:0052392 +name: induction by organism of defense-related symbiont calcium ion flux +namespace: biological_process +def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont Ca2+ flux" EXACT [] +synonym: "activation by organism of symbiont calcium ion flux" EXACT [] +synonym: "induction by organism of symbiont Ca2+ flux" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052393 +name: induction by host of symbiont defense response +namespace: biological_process +def: "The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "activation of symbiont defense response" EXACT [] +is_a: GO:0052197 ! positive regulation by host of symbiont defense response +is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052394 +name: induction by organism of defense-related symbiont cell wall thickening +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT [] +synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT [] +synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052395 +name: induction by organism of defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT [] +synonym: "activation by organism of defense-related symbiont NO production" EXACT [] +synonym: "induction by organism of defense-related symbiont NO production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052396 +name: induction by organism of symbiont non-apoptotic programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052397 +name: induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates programmed cell death by a non-apoptotic pathway in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of non-apoptotic programmed cell death in other organism" EXACT [] +is_a: GO:0052400 ! induction by organism of programmed cell death in other organism during symbiotic interaction +is_a: GO:0052518 ! positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052398 +name: induction by organism of symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont phytoalexin production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052399 +name: induction by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052400 +name: induction by organism of programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "The activation by an organism of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052401 +name: induction by organism of defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "activation by organism of defense-related symbiont AOS production" EXACT [] +synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT [] +synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT [] +synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "activation by organism of defense-related symbiont ROI production" EXACT [] +synonym: "activation by organism of defense-related symbiont ROS production" EXACT [] +synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "induction by organism of defense-related symbiont AOS production" EXACT [] +synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "induction by organism of defense-related symbiont ROI production" EXACT [] +synonym: "induction by organism of defense-related symbiont ROS production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052402 +name: induction by organism of symbiont resistance gene-dependent defense response +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT [] +synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT [] +synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052403 +name: negative regulation by host of symbiont enzyme activity +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by host of symbiont enzyme activity" EXACT [] +synonym: "down-regulation by host of symbiont enzyme activity" EXACT [] +synonym: "downregulation by host of symbiont enzyme activity" EXACT [] +synonym: "inhibition by host of symbiont enzyme activity" NARROW [] +synonym: "inhibition of symbiont enzyme activity" EXACT [] +is_a: GO:0052199 ! negative regulation of catalytic activity in other organism during symbiotic interaction +is_a: GO:0052405 ! negative regulation by host of symbiont molecular function +is_a: GO:0052422 ! modification by host of symbiont catalytic activity + +[Term] +id: GO:0052404 +name: negative regulation by host of symbiont peptidase activity +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "down regulation by host of symbiont protease activity" EXACT [] +synonym: "down-regulation by host of symbiont protease activity" EXACT [] +synonym: "downregulation by host of symbiont protease activity" EXACT [] +synonym: "inhibition by host of symbiont protease activity" NARROW [] +synonym: "inhibition of symbiont protease activity" EXACT [] +synonym: "negative regulation by host of symbiont protease activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052180 ! negative regulation of peptidase activity in other organism during symbiotic interaction +is_a: GO:0052403 ! negative regulation by host of symbiont enzyme activity +is_a: GO:0052427 ! modification by host of symbiont protease activity + +[Term] +id: GO:0052405 +name: negative regulation by host of symbiont molecular function +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "down regulation by host of symbiont protein function" EXACT [] +synonym: "down-regulation by host of symbiont protein function" EXACT [] +synonym: "downregulation by host of symbiont protein function" EXACT [] +synonym: "inhibition by host of symbiont protein function" NARROW [] +synonym: "inhibition of symbiont protein function" EXACT [] +synonym: "negative regulation by host of symbiont protein function" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction +is_a: GO:0052428 ! modification by host of symbiont molecular function + +[Term] +id: GO:0052406 +name: metabolism by host of symbiont carbohydrate +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction +is_a: GO:0052416 ! metabolism by host of symbiont macromolecule + +[Term] +id: GO:0052407 +name: metabolism by organism of carbohydrate in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction + +[Term] +id: GO:0052408 +name: metabolism by host of symbiont cell wall cellulose +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate +is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism during symbiotic interaction + +[Term] +id: GO:0052409 +name: metabolism by organism of cell wall cellulose in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052410 +name: metabolism by host of symbiont cell wall chitin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate +is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism during symbiotic interaction + +[Term] +id: GO:0052411 +name: metabolism by organism of cell wall chitin in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052412 +name: metabolism by host of symbiont cell wall pectin +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate +is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism during symbiotic interaction + +[Term] +id: GO:0052413 +name: metabolism by organism of cell wall pectin in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052414 +name: metabolism by host of symbiont glucan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate +is_a: GO:0052415 ! metabolism by organism of glucan in other organism during symbiotic interaction + +[Term] +id: GO:0052415 +name: metabolism by organism of glucan in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052416 +name: metabolism by host of symbiont macromolecule +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction +is_a: GO:0052419 ! metabolism by host of substance in symbiont + +[Term] +id: GO:0052417 +name: metabolism by host of symbiont protein +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052416 ! metabolism by host of symbiont macromolecule +is_a: GO:0052418 ! metabolism by organism of protein in other organism during symbiotic interaction + +[Term] +id: GO:0052418 +name: metabolism by organism of protein in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction + +[Term] +id: GO:0052419 +name: metabolism by host of substance in symbiont +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction + +[Term] +id: GO:0052420 +name: metabolism by host of symbiont xylan +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate +is_a: GO:0052421 ! metabolism by organism of xylan in other organism during symbiotic interaction + +[Term] +id: GO:0052421 +name: metabolism by organism of xylan in other organism during symbiotic interaction +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction + +[Term] +id: GO:0052422 +name: modification by host of symbiont catalytic activity +namespace: biological_process +def: "The process by which an organism effects a change in symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "modification by host of symbiont enzyme activity" EXACT [GOC:tb] +is_a: GO:0052203 ! modification of catalytic activity in other organism during symbiotic interaction +is_a: GO:0052428 ! modification by host of symbiont molecular function + +[Term] +id: GO:0052423 +name: positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of defense response in other organism by specific elicitors" EXACT [] +synonym: "positive regulation by organism of gene-for-gene resistance in other organism" EXACT [] +synonym: "stimulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052424 +name: modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system +namespace: biological_process +def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052425 +name: modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system +namespace: biological_process +def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052426 +name: modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system +namespace: biological_process +def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052427 +name: modification by host of symbiont protease activity +namespace: biological_process +def: "The process by which an organism effects a change in symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052198 ! modification of protease activity in other organism during symbiotic interaction +is_a: GO:0052422 ! modification by host of symbiont catalytic activity + +[Term] +id: GO:0052428 +name: modification by host of symbiont molecular function +namespace: biological_process +def: "The process by which an organism effects a change in the function of proteins in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "modification by host of symbiont protein function" EXACT [GOC:dph, GOC:tb] +is_a: GO:0052182 ! modification by host of symbiont morphology or physiology via secreted substance +is_a: GO:0052205 ! modification of molecular function in other organism during symbiotic interaction + +[Term] +id: GO:0052429 +name: modulation by organism of symbiont B-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052430 +name: modulation by host of symbiont RNA levels +namespace: biological_process +def: "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052249 ! modulation of RNA levels in other organism during symbiotic interaction + +[Term] +id: GO:0052431 +name: modulation by organism of symbiont T-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052432 +name: modulation by organism of symbiont apoptosis +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052433 +name: modulation by organism of apoptosis in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +is_a: GO:0042981 ! regulation of apoptosis +is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052434 +name: modulation by organism of symbiont cell-mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont cell-based immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052435 +name: modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT [] +synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] +is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction + +[Term] +id: GO:0052436 +name: modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052437 +name: modulation by organism of defense-related symbiont calcium ion flux +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052438 +name: modulation by organism of defense-related symbiont callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052439 +name: modulation by organism of defense-related symbiont cell wall callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052440 +name: modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052441 +name: modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052442 +name: modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052443 +name: modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of defense-related JA-mediated signal transduction pathway in other organism" EXACT [] +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052444 +name: modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052445 +name: modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "modulation of defense-related SA-mediated signal transduction pathway in other organism" EXACT [] +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052446 +name: modulation by organism of defense-related symbiont cell wall thickening +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052447 +name: modulation by organism of symbiont ethylene-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052448 +name: modulation by organism of ethylene levels in symbiont +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052449 +name: modulation by organism of ethylene levels in other organism during symbiotic interaction +namespace: biological_process +def: "The alteration by an organism of the levels of ethylene in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction + +[Term] +id: GO:0052450 +name: modulation by organism of induced systemic resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052451 +name: modulation by organism of symbiont inflammatory response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052452 +name: modulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052453 +name: modulation by organism of symbiont intracellular transport +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation of symbiont intracellular trafficking" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052454 +name: modulation by organism of symbiont jasmonic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052455 +name: modulation by organism of jasmonic acid levels in symbiont +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052456 +name: modulation by organism of jasmonic acid levels in other organism during symbiotic interaction +namespace: biological_process +def: "The alteration by an organism of the levels of jasmonic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction + +[Term] +id: GO:0052457 +name: modulation by organism of defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont NO production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052458 +name: modulation by organism of symbiont non-apoptotic programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052459 +name: modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death by a non-apoptotic pathway in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0043070 ! regulation of non-apoptotic programmed cell death +is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052460 +name: modulation by host of nutrient release from symbiont +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052313 ! modulation of nutrient release from other organism during symbiotic interaction +relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont + +[Term] +id: GO:0052461 +name: modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052462 +name: modulation by host of symbiont phagocytosis +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052231 ! modulation of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052463 +name: modulation by organism of symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052464 +name: modulation by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation of symbiont HR" BROAD [] +synonym: "modulation of symbiont hypersensitive response" NARROW [] +synonym: "modulation of symbiont PCD" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052465 +name: modulation by organism of defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "modulation by organism of defense-related symbiont AOS production" EXACT [] +synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] +synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "modulation by organism of defense-related symbiont ROI production" EXACT [] +synonym: "modulation by organism of defense-related symbiont ROS production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052466 +name: modulation by organism of symbiont resistance gene-dependent defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052467 +name: modulation by organism of symbiont salicylic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052468 +name: modulation by organism of salicylic acid levels in symbiont +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052469 +name: modulation by organism of salicylic acid levels in other organism during symbiotic interaction +namespace: biological_process +def: "The alteration by an organism of the levels of salicylic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction + +[Term] +id: GO:0052470 +name: modulation by host of symbiont signal transduction pathway +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052471 +name: modulation by organism of systemic acquired resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052472 +name: modulation by host of symbiont transcription +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of symbiont transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modification by host of symbiont morphology or physiology +is_a: GO:0052312 ! modulation of transcription in other organism during symbiotic interaction + +[Term] +id: GO:0052473 +name: negative regulation by organism of symbiont B-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052474 +name: negative regulation by organism of symbiont T-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052475 +name: negative regulation by organism of symbiont cell-mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052476 +name: negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. +synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052477 +name: negative regulation by organism of defense-related symbiont callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052478 +name: negative regulation by organism of defense-related symbiont cell wall callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. +is_obsolete: true + +[Term] +id: GO:0052479 +name: negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052480 +name: negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052481 +name: negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] +synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052482 +name: cell wall thickening during defense response +namespace: biological_process +def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06] +is_a: GO:0006952 ! defense response +is_a: GO:0052386 ! cell wall thickening + +[Term] +id: GO:0052483 +name: negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops or prevents itself undergoing phagocytosis into a cell in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" NARROW [] +synonym: "negative regulation by organism of entry into cell of other organism via other organism phagocytosis during symbiotic interaction" EXACT [] +is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction +is_a: GO:0052373 ! negative regulation by organism of entry into other organism during symbiotic interaction +is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis during symbiotic interaction + +[Term] +id: GO:0052484 +name: negative regulation by organism of symbiont ethylene-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052485 +name: negative regulation by organism of symbiont inflammatory response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052486 +name: negative regulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052487 +name: negative regulation by organism of symbiont jasmonic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052488 +name: negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT [] +synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT [] +synonym: "suppression of MAMP induced symbiont innate immunity" EXACT [] +synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT [] +synonym: "suppression of PAMP induced symbiont innate immunity" EXACT [] +synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT [] +synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052489 +name: negative regulation by host of symbiont programmed cell death +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by host of symbiont programmed cell death" EXACT [] +synonym: "down-regulation by host of symbiont programmed cell death" EXACT [] +synonym: "downregulation by host of symbiont programmed cell death" EXACT [] +synonym: "inhibition by host of symbiont programmed cell death" NARROW [] +synonym: "inhibition of symbiont programmed cell death" EXACT [] +is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052490 +name: negative regulation by organism of programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of programmed cell death in other organism during symbiotic interaction" NARROW [] +synonym: "inhibition of programmed cell death in other organism" EXACT [] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052491 +name: negative regulation by organism of symbiont salicylic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation of symbiont SA-mediated defense response" EXACT [] +synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT [] +synonym: "suppression of symbiont SA mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052492 +name: negative regulation by host of symbiont signal transduction pathway +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "downregulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "inhibition by host of symbiont signal transduction pathway" NARROW [] +synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT [] +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway +is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052493 +name: negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "negative modulation by organism of other organism signal transduction pathway" EXACT [] +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052494 +name: occlusion by host of symbiont vascular system +namespace: biological_process +def: "The process by which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] +subset: gosubset_prok +is_a: GO:0052183 ! modification by host of symbiont structure +is_a: GO:0052495 ! occlusion by organism of vascular system in other organism during symbiotic interaction + +[Term] +id: GO:0052495 +name: occlusion by organism of vascular system in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] +subset: gosubset_prok +is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction + +[Term] +id: GO:0052496 +name: occlusion by host of symbiont xylem +namespace: biological_process +def: "The process by which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052494 ! occlusion by host of symbiont vascular system +is_a: GO:0052497 ! occlusion by organism of xylem in other organism during symbiotic interaction + +[Term] +id: GO:0052497 +name: occlusion by organism of xylem in other organism during symbiotic interaction +namespace: biological_process +def: "The process by which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052495 ! occlusion by organism of vascular system in other organism during symbiotic interaction + +[Term] +id: GO:0052498 +name: pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT [] +synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT [] +synonym: "MAMP dependent activation of symbiont innate immunity" EXACT [] +synonym: "MAMP dependent induction of symbiont innate immunity" EXACT [] +synonym: "PAMP dependent activation of symbiont innate immunity" EXACT [] +synonym: "PAMP dependent induction of symbiont innate immunity" EXACT [] +synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052499 +name: pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052500 +name: positive regulation by organism of symbiont apoptosis +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052501 +name: positive regulation by organism of apoptosis in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "stimulation by organism of apoptosis in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of apoptosis in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of apoptosis in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of apoptosis in other organism during symbiotic interaction" EXACT [] +is_a: GO:0043065 ! positive regulation of apoptosis +is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction +is_a: GO:0052433 ! modulation by organism of apoptosis in other organism during symbiotic interaction + +[Term] +id: GO:0052502 +name: positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction +is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway +is_a: GO:0075100 ! positive regulation by host of symbiont protein kinase-mediated signal transduction + +[Term] +id: GO:0052503 +name: positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052504 +name: positive regulation by organism of defense-related symbiont callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW [] +synonym: "induction by organism of defense-related symbiont callose deposition" NARROW [] +synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052505 +name: positive regulation by organism of defense-related symbiont cell wall callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052506 +name: positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052507 +name: positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052508 +name: positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052509 +name: positive regulation by symbiont of host defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host defense response" NARROW [] +synonym: "stimulation by symbiont of host defense response" NARROW [] +synonym: "up regulation by symbiont of host defense response" EXACT [] +synonym: "up-regulation by symbiont of host defense response" EXACT [] +synonym: "upregulation by symbiont of host defense response" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052510 +name: positive regulation by organism of defense response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense response of other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of defense response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052511 +name: positive regulation by organism of symbiont ethylene-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW [] +synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW [] +synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052512 +name: positive regulation by organism of hormone or growth regulator levels in symbiont +namespace: biological_process +def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052513 +name: positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction +namespace: biological_process +def: "The increase by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW [] +synonym: "positive modulation of hormone or growth regulator levels in other organism" EXACT [] +synonym: "stimulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction + +[Term] +id: GO:0052514 +name: positive regulation by organism of symbiont inflammatory response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052515 +name: positive regulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052516 +name: positive regulation by organism of symbiont jasmonic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of symbiont JA-mediated defense response" NARROW [] +synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052517 +name: positive regulation by organism of symbiont non-apoptotic programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052518 +name: positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by a non-apoptotic pathway in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" EXACT [] +is_a: GO:0043071 ! positive regulation of non-apoptotic programmed cell death +is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction +is_a: GO:0052459 ! modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052519 +name: positive regulation by host of nutrient release from symbiont +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by host of nutrient release from symbiont" NARROW [] +synonym: "promotion of nutrient release from symbiont" EXACT [] +synonym: "stimulation by host of nutrient release from symbiont" NARROW [] +synonym: "up regulation by host of nutrient release from symbiont" EXACT [] +synonym: "up-regulation by host of nutrient release from symbiont" EXACT [] +synonym: "upregulation by host of nutrient release from symbiont" EXACT [] +is_a: GO:0052460 ! modulation by host of nutrient release from symbiont +is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism during symbiotic interaction + +[Term] +id: GO:0052520 +name: positive regulation by organism of nutrient release from other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] +synonym: "promotion of nutrient release from other organism" EXACT [] +synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" EXACT [] +is_a: GO:0052313 ! modulation of nutrient release from other organism during symbiotic interaction + +[Term] +id: GO:0052521 +name: positive regulation by host of symbiont phagocytosis +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by host of symbiont phagocytosis" NARROW [] +synonym: "stimulation by host of symbiont phagocytosis" NARROW [] +synonym: "up regulation by host of symbiont phagocytosis" EXACT [] +synonym: "up-regulation by host of symbiont phagocytosis" EXACT [] +synonym: "upregulation by host of symbiont phagocytosis" EXACT [] +is_a: GO:0052462 ! modulation by host of symbiont phagocytosis +is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052522 +name: positive regulation by organism of phagocytosis in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" EXACT [] +is_a: GO:0050766 ! positive regulation of phagocytosis +is_a: GO:0052231 ! modulation of phagocytosis in other organism during symbiotic interaction + +[Term] +id: GO:0052523 +name: positive regulation by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "enhancement or induction of symbiont programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052524 +name: positive regulation by organism of symbiont salicylic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of symbiont SA-mediated defense response" NARROW [] +synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052525 +name: positive regulation by host of symbiont signal transduction pathway +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by host of symbiont signal transduction pathway" NARROW [] +synonym: "stimulation by host of symbiont signal transduction pathway" NARROW [] +synonym: "up regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "upregulation by host of symbiont signal transduction pathway" EXACT [] +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway +is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052526 +name: positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction + +[Term] +id: GO:0052527 +name: positive regulation by symbiont of host resistance gene-dependent defense response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host resistance gene-dependent defense response" NARROW [] +synonym: "positive regulation by organism of defense response in host by specific elicitors" EXACT [] +synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT [] +synonym: "positive regulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "stimulation by symbiont of host resistance gene-dependent defense response" NARROW [] +synonym: "up regulation by symbiont of host resistance gene-dependent defense response" EXACT [] +synonym: "up-regulation by symbiont of host resistance gene-dependent defense response" EXACT [] +synonym: "upregulation by symbiont of host resistance gene-dependent defense response" EXACT [] +is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response +is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052528 +name: upregulation by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "enhancement of symbiont programmed cell death by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052529 +name: upregulation by organism of programmed cell death in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism increases the frequency, rate or extent of programmed cell death in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "enhancement of other organism programmed cell death by organism" EXACT [] +is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction + +[Term] +id: GO:0052530 +name: positive regulation by organism of symbiont resistance gene-dependent defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052531 +name: positive regulation by organism of defense-related symbiont calcium ion flux +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052532 +name: positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT [] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052533 +name: positive regulation by symbiont of induced systemic resistance in host +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of induced systemic resistance in host" NARROW [] +synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW [] +synonym: "up regulation by symbiont of induced systemic resistance in host" EXACT [] +synonym: "up-regulation by symbiont of induced systemic resistance in host" EXACT [] +synonym: "upregulation by symbiont of induced systemic resistance in host" EXACT [] +is_a: GO:0052159 ! modulation by symbiont of induced systemic resistance in host +is_a: GO:0052509 ! positive regulation by symbiont of host defense response +is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052534 +name: positive regulation by organism of induced systemic resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052535 +name: positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of systemic acquired resistance in other organism during symbiotic interaction" EXACT [] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052536 +name: positive regulation by organism of systemic acquired resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052537 +name: positive regulation by symbiont of systemic acquired resistance in host +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of systemic acquired resistance in host" NARROW [] +synonym: "stimulation by symbiont of systemic acquired resistance in host" NARROW [] +synonym: "up regulation by symbiont of systemic acquired resistance in host" EXACT [] +synonym: "up-regulation by symbiont of systemic acquired resistance in host" EXACT [] +synonym: "upregulation by symbiont of systemic acquired resistance in host" EXACT [] +is_a: GO:0052160 ! modulation by symbiont of systemic acquired resistance in host +is_a: GO:0052509 ! positive regulation by symbiont of host defense response +is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction +is_a: GO:0052556 ! positive regulation by symbiont of host immune response + +[Term] +id: GO:0052538 +name: positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" EXACT [] +synonym: "stimulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT [] +is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction +is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction + +[Term] +id: GO:0052539 +name: positive regulation by symbiont of defense-related host cell wall thickening +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of a host process resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of defense-related host cell wall thickening" NARROW [] +synonym: "positive regulation by organism of host defensive cell wall thickening" EXACT [] +synonym: "stimulation by symbiont of defense-related host cell wall thickening" NARROW [] +synonym: "up regulation by symbiont of defense-related host cell wall thickening" EXACT [] +synonym: "up-regulation by symbiont of defense-related host cell wall thickening" EXACT [] +synonym: "upregulation by symbiont of defense-related host cell wall thickening" EXACT [] +is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening +is_a: GO:0052509 ! positive regulation by symbiont of host defense response +is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction + +[Term] +id: GO:0052540 +name: positive regulation by organism of defense-related symbiont cell wall thickening +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052541 +name: plant-type cell wall cellulose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "cell wall cellulose metabolism" EXACT [] +synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT [] +is_a: GO:0009664 ! plant-type cell wall organization +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0030243 ! cellulose metabolic process + +[Term] +id: GO:0052542 +name: callose deposition during defense response +namespace: biological_process +def: "Any process by which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] +synonym: "callose localization during defense response" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0052545 ! callose localization + +[Term] +id: GO:0052543 +name: callose deposition in cell wall +namespace: biological_process +def: "Any process by which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] +synonym: "callose localization in cell wall" EXACT [] +synonym: "cell wall callose deposition" EXACT [] +synonym: "cell wall callose localization" EXACT [] +is_a: GO:0052386 ! cell wall thickening +is_a: GO:0052545 ! callose localization + +[Term] +id: GO:0052544 +name: callose deposition in cell wall during defense response +namespace: biological_process +def: "Any process by which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] +synonym: "callose localization in cell wall during defense response" EXACT [] +synonym: "cell wall callose deposition during defense response" EXACT [] +synonym: "cell wall callose localization during defense response" EXACT [] +is_a: GO:0052482 ! cell wall thickening during defense response +is_a: GO:0052542 ! callose deposition during defense response +is_a: GO:0052543 ! callose deposition in cell wall + +[Term] +id: GO:0052545 +name: callose localization +namespace: biological_process +def: "Any process by which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, http://www.onelook.com] +is_a: GO:0033037 ! polysaccharide localization + +[Term] +id: GO:0052546 +name: cell wall pectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] +synonym: "cell wall pectin metabolism" EXACT [] +synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT [] +synonym: "pectin metabolism during cell wall organization and biogenesis" EXACT [] +synonym: "plant-type cell wall pectin metabolic process" EXACT [] +is_a: GO:0009664 ! plant-type cell wall organization +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0045488 ! pectin metabolic process + +[Term] +id: GO:0052547 +name: regulation of peptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [EC:3.4, GOC:ai] +synonym: "peptidase regulator activity" RELATED [] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0052548 +name: regulation of endopeptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd] +synonym: "protease regulator activity" RELATED [] +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:0052549 +name: response to phytoalexin production by other organism during symbiotic interaction +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052550 +name: response to defense-related reactive oxygen species production by other organism during symbiotic interaction +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052551 +name: response to defense-related nitric oxide production by other organism during symbiotic interaction +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052552 +name: modulation by organism of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0050776 ! regulation of immune response +is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction +is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052553 +name: modulation by symbiont of host immune response +namespace: biological_process +def: "Any process by which an organism modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0052554 +name: modulation by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052555 +name: positive regulation by organism of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of immune response of other organism during symbiotic interaction" NARROW [] +synonym: "stimulation by organism of immune response of other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of immune response of other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of immune response of other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of immune response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052556 +name: positive regulation by symbiont of host immune response +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by symbiont of host immune response" NARROW [] +synonym: "stimulation by symbiont of host immune response" NARROW [] +synonym: "up regulation by symbiont of host immune response" EXACT [] +synonym: "up-regulation by symbiont of host immune response" EXACT [] +synonym: "upregulation by symbiont of host immune response" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052557 +name: positive regulation by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052558 +name: induction by organism of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism activates the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "activation by organism of immune response of other organism during symbiotic interaction" EXACT [] +is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052559 +name: induction by symbiont of host immune response +namespace: biological_process +def: "Any process by which an organism activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052556 ! positive regulation by symbiont of host immune response +is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052560 +name: induction by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052561 +name: negative regulation by organism of immune response of other organism during symbiotic interaction +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by organism of immune response of other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation by organism of immune response of other organism during symbiotic interaction" EXACT [] +synonym: "downregulation by organism of immune response of other organism during symbiotic interaction" EXACT [] +synonym: "inhibition by organism of immune response of other organism during symbiotic interaction" NARROW [] +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052562 +name: negative regulation by symbiont of host immune response +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +synonym: "down regulation by symbiont of host immune response" EXACT [] +synonym: "down-regulation by symbiont of host immune response" EXACT [] +synonym: "downregulation by symbiont of host immune response" EXACT [] +synonym: "inhibition by symbiont of host immune response" NARROW [] +is_a: GO:0052553 ! modulation by symbiont of host immune response +is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction + +[Term] +id: GO:0052563 +name: negative regulation by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052564 +name: response to immune response of other organism during symbiotic interaction +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction + +[Term] +id: GO:0052565 +name: response to defense-related host nitric oxide production +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism during symbiotic interaction +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0052566 +name: response to host phytoalexin production +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052549 ! response to phytoalexin production by other organism during symbiotic interaction +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0052567 +name: response to defense-related host reactive oxygen species production +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism during symbiotic interaction +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0052568 +name: response to symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052569 +name: response to defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052570 +name: response to defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052571 +name: response to symbiont immune response +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +is_obsolete: true + +[Term] +id: GO:0052572 +name: response to host immune response +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +subset: gosubset_prok +is_a: GO:0052200 ! response to host defenses +is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction + +[Term] +id: GO:0055001 +name: muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0055002 +name: striated muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] +is_a: GO:0055001 ! muscle cell development +relationship: part_of GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0055003 +name: cardiac myofibril assembly +namespace: biological_process +def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] +synonym: "cardiac myofibril development" EXACT [] +synonym: "cardiac myofibril morphogenesis" EXACT [] +synonym: "heart myofibril assembly" RELATED [] +is_a: GO:0030239 ! myofibril assembly +relationship: part_of GO:0055013 ! cardiac muscle cell development + +[Term] +id: GO:0055004 +name: atrial cardiac myofibril development +namespace: biological_process +def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] +synonym: "atrial heart myofibril development" EXACT [] +is_a: GO:0055003 ! cardiac myofibril assembly +relationship: part_of GO:0055014 ! atrial cardiac muscle cell development + +[Term] +id: GO:0055005 +name: ventricular cardiac myofibril development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] +synonym: "ventricular heart myofibril development" EXACT [] +is_a: GO:0055003 ! cardiac myofibril assembly +relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development + +[Term] +id: GO:0055006 +name: cardiac cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] +synonym: "heart cell development" RELATED [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0035051 ! cardiac cell differentiation + +[Term] +id: GO:0055007 +name: cardiac muscle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol] +synonym: "cardiomyocyte differentiation" EXACT [] +synonym: "heart muscle cell differentiation" RELATED [] +is_a: GO:0035051 ! cardiac cell differentiation +is_a: GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0055008 +name: cardiac muscle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of cardiac muscle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:devbiol] +synonym: "heart muscle morphogensis" EXACT [] +is_a: GO:0048644 ! muscle morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0055009 +name: atrial cardiac muscle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structure of cardiac atrium muscle is generated and organized. Morphogenesis pertains to the creation of form." [GOC:devbiol] +synonym: "atrial heart muscle morphogenesis" EXACT [] +synonym: "cardiac atrium muscle morphogenesis" EXACT [] +is_a: GO:0055008 ! cardiac muscle morphogenesis + +[Term] +id: GO:0055010 +name: ventricular cardiac muscle morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form." [GOC:devbiol] +synonym: "cardiac ventricle muscle morphogenesis" EXACT [] +synonym: "ventricular heart muscle morphogenesis" EXACT [] +is_a: GO:0055008 ! cardiac muscle morphogenesis + +[Term] +id: GO:0055011 +name: atrial cardiac muscle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that allows blood to return to the organ." [GOC:devbiol] +synonym: "atrial cardiomyocyte differentiation" EXACT [] +synonym: "atrial heart muscle cell differentiation" EXACT [] +is_a: GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0055012 +name: ventricular cardiac muscle cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood away from the organ." [GOC:devbiol] +synonym: "ventricular cardiomyocyte differentiation" EXACT [] +synonym: "ventricular heart muscle cell differentiation" EXACT [] +is_a: GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0055013 +name: cardiac muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol] +synonym: "heart muscle cell development" EXACT [] +is_a: GO:0055001 ! muscle cell development + +[Term] +id: GO:0055014 +name: atrial cardiac muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that allows blood to return to the organ." [GOC:devbiol] +synonym: "atrial cardiomyocyte development" EXACT [] +synonym: "atrial heart muscle development" EXACT [] +is_a: GO:0055013 ! cardiac muscle cell development +relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation + +[Term] +id: GO:0055015 +name: ventricular cardiac muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood away from the organ." [GOC:devbiol, GOC:mtg_muscle] +synonym: "ventricular cardiomyocyte development" EXACT [] +synonym: "ventricular heart muscle cell development" EXACT [] +is_a: GO:0055013 ! cardiac muscle cell development +relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation + +[Term] +id: GO:0055016 +name: hypochord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb] +synonym: "subnotochordal rod development" EXACT [] +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0055017 +name: cardiac muscle growth +namespace: biological_process +def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] +synonym: "heart muscle growth" EXACT [] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048738 ! cardiac muscle development + +[Term] +id: GO:0055018 +name: regulation of cardiac muscle fiber development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] +synonym: "regulation of cardiac muscle fibre development" EXACT [] +synonym: "regulation of heart muscle fiber development" EXACT [] +is_a: GO:0055024 ! regulation of cardiac muscle development +relationship: regulates GO:0048739 ! cardiac muscle fiber development + +[Term] +id: GO:0055019 +name: negative regulation of cardiac muscle fiber development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] +synonym: "down regulation of cardiac muscle fiber development" EXACT [] +synonym: "down-regulation of cardiac muscle fiber development" EXACT [] +synonym: "downregulation of cardiac muscle fiber development" EXACT [] +synonym: "inhibition of cardiac muscle fiber development" NARROW [] +synonym: "negative regulation of cardiac muscle fibre development" EXACT [] +synonym: "negative regulation of heart muscle fiber development" RELATED [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0055018 ! regulation of cardiac muscle fiber development +relationship: negatively_regulates GO:0048739 ! cardiac muscle fiber development +relationship: part_of GO:0055026 ! negative regulation of cardiac muscle development + +[Term] +id: GO:0055020 +name: positive regulation of cardiac muscle fiber development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] +synonym: "activation of cardiac muscle fiber development" NARROW [] +synonym: "positive regulation of cardiac muscle fibre development" EXACT [] +synonym: "positive regulation of heart muscle fiber development" EXACT [] +synonym: "stimulation of cardiac muscle fiber development" NARROW [] +synonym: "up regulation of cardiac muscle fiber development" EXACT [] +synonym: "up-regulation of cardiac muscle fiber development" EXACT [] +synonym: "upregulation of cardiac muscle fiber development" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0055018 ! regulation of cardiac muscle fiber development +relationship: part_of GO:0055025 ! positive regulation of cardiac muscle development +relationship: positively_regulates GO:0048739 ! cardiac muscle fiber development + +[Term] +id: GO:0055021 +name: regulation of cardiac muscle growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0055024 ! regulation of cardiac muscle development +relationship: regulates GO:0055017 ! cardiac muscle growth + +[Term] +id: GO:0055022 +name: negative regulation of cardiac muscle growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] +synonym: "down regulation of cardiac muscle growth" EXACT [] +synonym: "down-regulation of cardiac muscle growth" EXACT [] +synonym: "downregulation of cardiac muscle growth" EXACT [] +synonym: "inhibition of cardiac muscle growth" NARROW [] +synonym: "negative regulation of heart muscle growth" RELATED [] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0055021 ! regulation of cardiac muscle growth +relationship: negatively_regulates GO:0055017 ! cardiac muscle growth +relationship: part_of GO:0055026 ! negative regulation of cardiac muscle development + +[Term] +id: GO:0055023 +name: positive regulation of cardiac muscle growth +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] +synonym: "activation of cardiac muscle growth" NARROW [] +synonym: "positive regulation of heart muscle growth" EXACT [] +synonym: "stimulation of cardiac muscle growth" NARROW [] +synonym: "up regulation of cardiac muscle growth" EXACT [] +synonym: "up-regulation of cardiac muscle growth" EXACT [] +synonym: "upregulation of cardiac muscle growth" EXACT [] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0055021 ! regulation of cardiac muscle growth +relationship: part_of GO:0055025 ! positive regulation of cardiac muscle development +relationship: positively_regulates GO:0055017 ! cardiac muscle growth + +[Term] +id: GO:0055024 +name: regulation of cardiac muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle development." [GOC:vk] +synonym: "regulation of heart muscle development" EXACT [] +is_a: GO:0016202 ! regulation of striated muscle development +relationship: regulates GO:0048738 ! cardiac muscle development + +[Term] +id: GO:0055025 +name: positive regulation of cardiac muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle development." [GOC:vk] +synonym: "activation of cardiac muscle development" NARROW [] +synonym: "positive regulation of heart muscle development" EXACT [] +synonym: "stimulation of cardiac muscle development" NARROW [] +synonym: "up regulation of cardiac muscle development" EXACT [] +synonym: "up-regulation of cardiac muscle development" EXACT [] +synonym: "upregulation of cardiac muscle development" EXACT [] +is_a: GO:0045844 ! positive regulation of striated muscle development +is_a: GO:0055024 ! regulation of cardiac muscle development +relationship: positively_regulates GO:0048738 ! cardiac muscle development + +[Term] +id: GO:0055026 +name: negative regulation of cardiac muscle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle development." [GOC:vk] +synonym: "down regulation of cardiac muscle development" EXACT [] +synonym: "down-regulation of cardiac muscle development" EXACT [] +synonym: "downregulation of cardiac muscle development" EXACT [] +synonym: "inhibition of cardiac muscle development" NARROW [] +synonym: "negative regulation of heart muscle development" EXACT [] +is_a: GO:0045843 ! negative regulation of striated muscle development +is_a: GO:0055024 ! regulation of cardiac muscle development +relationship: negatively_regulates GO:0048738 ! cardiac muscle development + +[Term] +id: GO:0055028 +name: cortical microtubule +namespace: cellular_component +def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu] +is_a: GO:0005881 ! cytoplasmic microtubule +is_a: GO:0044448 ! cell cortex part +relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton + +[Term] +id: GO:0055029 +name: nuclear DNA-directed RNA polymerase complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex + +[Term] +id: GO:0055030 +name: peptidoglycan-based spore wall +namespace: cellular_component +def: "A spore wall consisting of a peptidoglycan-containing inner layer (the spore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:mtg_sensu, PMID:15035041] +synonym: "spore wall (sensu Bacteria)" EXACT [] +is_a: GO:0031160 ! spore wall + +[Term] +id: GO:0055031 +name: gamma-tubulin large complex, equatorial microtubule organizing center +namespace: cellular_component +def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers." [GOC:mtg_sensu] +synonym: "gamma-tubulin large complex, eMTOC" EXACT [] +synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" EXACT [] +is_a: GO:0000931 ! gamma-tubulin large complex +is_a: GO:0032155 ! cell division site part +relationship: part_of GO:0000923 ! equatorial microtubule organizing center + +[Term] +id: GO:0055032 +name: gamma-tubulin large complex, spindle pole body +namespace: cellular_component +def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body." [GOC:mtg_sensu] +is_a: GO:0000931 ! gamma-tubulin large complex +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0055033 +name: gamma-tubulin large complex, interphase microtubule organizing center +namespace: cellular_component +def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers." [GOC:mtg_sensu] +synonym: "gamma-tubulin large complex, iMTOC" EXACT [] +synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" EXACT [] +is_a: GO:0000931 ! gamma-tubulin large complex +relationship: part_of GO:0031021 ! interphase microtubule organizing center + +[Term] +id: GO:0055034 +name: Bolwig's organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu] +is_a: GO:0001654 ! eye development + +[Term] +id: GO:0055035 +name: plastid thylakoid membrane +namespace: cellular_component +def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jic, GOC:rph] +is_a: GO:0042651 ! thylakoid membrane +is_a: GO:0044435 ! plastid part +relationship: part_of GO:0031976 ! plastid thylakoid + +[Term] +id: GO:0055036 +name: virion membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a virion." [GOC:jic, GOC:rph, PMID:213106] +is_a: GO:0044423 ! virion part + +[Term] +id: GO:0055037 +name: recycling endosome +namespace: cellular_component +def: "Organelle consisting of networks of 60nm tubules organized around the microtubule organizing centre in some cell types. They transport receptors from late endosomes back to the plasma membrane for recycling and are also involved in membrane trafficking." [GOC:jic, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0055038 +name: recycling endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a recycling endosome." [GOC:jic, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0055037 ! recycling endosome + +[Term] +id: GO:0055039 +name: trichocyst +namespace: cellular_component +def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in \"nets\" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jic, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715] +is_a: GO:0043264 ! extracellular non-membrane-bounded organelle + +[Term] +id: GO:0055040 +name: periplasmic flagellum +namespace: cellular_component +def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jic, GOC:rph, PMID:15175283, PMID:1624463] +is_a: GO:0009288 ! flagellin-based flagellum +relationship: part_of GO:0042597 ! periplasmic space + +[Term] +id: GO:0055041 +name: cyclopentanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + NADH + H+." [EC:1.1.1.163, GOC:jic, GOC:mlg] +synonym: "cyclopentanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.163] +synonym: "cyclopentanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.163] +xref: EC:1.1.1.163 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0055042 +name: 5-valerolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jic, GOC:mlg] +is_a: GO:0046573 ! lactonohydrolase activity + +[Term] +id: GO:0055043 +name: 5-oxovalerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jic, GOC:mlg] +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0055044 +name: symplast +namespace: cellular_component +def: "The interconnected protoplasts of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu] +subset: goslim_pir +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0055045 +name: antipodal cell degeneration +namespace: biological_process +def: "The process whereby the antipodal cells undergo programmed cell death." [GOC:mtg_plant] +is_a: GO:0010623 ! developmental programmed cell death +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0055046 +name: microgametogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant] +synonym: "pollen development from the microspore" EXACT systematic_synonym [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0055047 +name: generative cell mitosis +namespace: biological_process +def: "The process whereby the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant] +is_a: GO:0007067 ! mitosis +relationship: part_of GO:0048232 ! male gamete generation + +[Term] +id: GO:0055048 +name: anastral spindle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:mtg_sensu, GOC:rg, GOC:tb, PMID:15034926] +is_a: GO:0051225 ! spindle assembly + +[Term] +id: GO:0055049 +name: astral spindle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb] +is_a: GO:0051225 ! spindle assembly + +[Term] +id: GO:0055050 +name: astral spindle assembly involved in male meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb] +is_a: GO:0055049 ! astral spindle assembly + +[Term] +id: GO:0055051 +name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding +namespace: cellular_component +def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a \"half transporter\". Two \"half-transporters\" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:0055052 +name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing +namespace: cellular_component +def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:0055053 +name: mannose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct] +is_a: GO:0009679 ! hexose:hydrogen symporter activity +is_a: GO:0015578 ! mannose transmembrane transporter activity + +[Term] +id: GO:0055054 +name: fructose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct] +is_a: GO:0005353 ! fructose transmembrane transporter activity +is_a: GO:0009679 ! hexose:hydrogen symporter activity + +[Term] +id: GO:0055055 +name: D-glucose:hydrogen symporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory isomer of glucose." [GOC:ct] +is_a: GO:0005356 ! hydrogen:glucose symporter activity +is_a: GO:0055056 ! D-glucose transmembrane transporter activity + +[Term] +id: GO:0055056 +name: D-glucose transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of the dextrorotatory isomer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:jic] +is_a: GO:0005355 ! glucose transmembrane transporter activity + +[Term] +id: GO:0055057 +name: neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] +synonym: "neuroblast cell division" EXACT [] +is_a: GO:0048103 ! somatic stem cell division +relationship: part_of GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:0055058 +name: symmetric neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph] +is_a: GO:0055057 ! neuroblast division + +[Term] +id: GO:0055059 +name: asymmetric neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +is_a: GO:0055057 ! neuroblast division + +[Term] +id: GO:0055060 +name: asymmetric neuroblast division resulting in ganglion mother cell formation +namespace: biological_process +def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph] +is_a: GO:0014017 ! neuroblast fate commitment +is_a: GO:0055059 ! asymmetric neuroblast division + +[Term] +id: GO:0055061 +name: di-, tri-valent inorganic anion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic anions." [GOC:ai, GOC:jid] +is_a: GO:0055081 ! anion homeostasis + +[Term] +id: GO:0055062 +name: phosphate ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of phosphate ions." [GOC:jid, GOC:mah] +is_a: GO:0055061 ! di-, tri-valent inorganic anion homeostasis + +[Term] +id: GO:0055063 +name: sulfate ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of sulfate ions." [GOC:jid, GOC:mah] +synonym: "sulphate ion homeostasis" EXACT [] +is_a: GO:0055061 ! di-, tri-valent inorganic anion homeostasis + +[Term] +id: GO:0055064 +name: chloride ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of chloride ions." [GOC:jid, GOC:mah] +is_a: GO:0055083 ! monovalent inorganic anion homeostasis + +[Term] +id: GO:0055065 +name: metal ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of metal ions." [GOC:ai, GOC:jid] +subset: gosubset_prok +is_a: GO:0055080 ! cation homeostasis + +[Term] +id: GO:0055066 +name: di-, tri-valent inorganic cation homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of divalent and trivalent inorganic cations." [GOC:ceb, GOC:jid] +subset: gosubset_prok +is_a: GO:0055080 ! cation homeostasis + +[Term] +id: GO:0055067 +name: monovalent inorganic cation homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of monovalent inorganic cations." [GOC:ai, GOC:jid] +subset: gosubset_prok +is_a: GO:0055080 ! cation homeostasis + +[Term] +id: GO:0055068 +name: cobalt ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of cobalt ions." [GOC:ai, GOC:jid] +synonym: "cobalt homeostasis" BROAD [] +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055069 +name: zinc ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of zinc ions." [GOC:ai, GOC:jid] +synonym: "zinc homeostasis" BROAD [] +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055070 +name: copper ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of copper ions." [GOC:ai, GOC:jid] +subset: gosubset_prok +synonym: "copper homeostasis" BROAD [] +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055071 +name: manganese ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of manganese ions." [GOC:jid, GOC:mah] +subset: gosubset_prok +synonym: "manganese homeostasis" BROAD [] +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055072 +name: iron ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of iron ions." [GOC:ai, GOC:jid] +subset: gosubset_prok +synonym: "iron homeostasis" BROAD [] +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055073 +name: cadmium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of cadmium ions." [GOC:ai, GOC:jid] +synonym: "cadmium homeostasis" EXACT [] +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055074 +name: calcium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of calcium ions." [GOC:ceb, GOC:jid] +synonym: "regulation of calcium ion concentration" EXACT [] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis + +[Term] +id: GO:0055075 +name: potassium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of potassium ions." [GOC:jid, GOC:mah] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0055076 +name: transition metal ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of transition metal ions. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0055065 ! metal ion homeostasis + +[Term] +id: GO:0055077 +name: gap junction hemi-channel activity +namespace: molecular_function +def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh] +synonym: "connexon channel activity" EXACT [] +is_a: GO:0022829 ! wide pore channel activity +relationship: part_of GO:0005243 ! gap junction channel activity + +[Term] +id: GO:0055078 +name: sodium ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of sodium ions." [GOC:ai, GOC:jid] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0055079 +name: aluminum ion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of aluminum ions." [GOC:jid, GOC:lr] +is_a: GO:0055065 ! metal ion homeostasis + +[Term] +id: GO:0055080 +name: cation homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of cations." [GOC:ceb, GOC:jid] +subset: gosubset_prok +is_a: GO:0050801 ! ion homeostasis + +[Term] +id: GO:0055081 +name: anion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of anions." [GOC:ceb, GOC:jid] +is_a: GO:0050801 ! ion homeostasis + +[Term] +id: GO:0055082 +name: cellular chemical homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal equilibrium of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid] +subset: gosubset_prok +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0055083 +name: monovalent inorganic anion homeostasis +namespace: biological_process +def: "The regulation of the levels, transport, and metabolism of monovalent inorganic anions." [GOC:ai, GOC:jid] +is_a: GO:0055081 ! anion homeostasis + +[Term] +id: GO:0055084 +name: fruiting body development in response to starvation +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins with a response to a lack of nutrients and ends when the fruiting body is a mature structure." [GOC:mtg_sensu] +is_a: GO:0030582 ! fruiting body development +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0055085 +name: transmembrane transport +namespace: biological_process +def: "The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute." [GOC:jid] +is_a: GO:0006810 ! transport +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0055086 +name: nucleobase, nucleoside and nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nucleobases, nucleosides and nucleotides." [GOC:vw] +subset: gosubset_prok +synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] +is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process + +[Term] +id: GO:0055087 +name: Ski complex +namespace: cellular_component +def: "A heterotrimeric protein complex that regulates RNA degradation by the exosome complex." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509] +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0055088 +name: lipid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of lipid within an organism or cell." [GOC:rl] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0055089 +name: fatty acid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of fatty acid within an organism or cell." [GOC:rl] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055090 +name: acylglycerol homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of acylglycerol within an organism or cell." [GOC:rl] +synonym: "glyceride homeostasis" EXACT [] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055091 +name: phospholipid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of phospholipid within an organism or cell." [GOC:rl] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055092 +name: sterol homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of sterol within an organism or cell." [GOC:rl] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055093 +name: response to hyperoxia +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv] +synonym: "response to hyperoxic stress" EXACT [] +synonym: "response to increased oxygen tension" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0055094 +name: response to lipoprotein stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein stimulus." [GOC:rl] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0055095 +name: lipoprotein mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of lipoprotein." [GOC:rl] +synonym: "lipoprotein mediated signalling " EXACT [] +is_a: GO:0007242 ! intracellular signaling cascade +relationship: part_of GO:0055094 ! response to lipoprotein stimulus + +[Term] +id: GO:0055096 +name: low density lipoprotein mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of low density lipoprotein." [GOC:rl] +synonym: "low density lipoprotein mediated signalling" EXACT [] +is_a: GO:0055095 ! lipoprotein mediated signaling +relationship: part_of GO:0055098 ! response to low density lipoprotein stimulus + +[Term] +id: GO:0055097 +name: high density lipoprotein mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of high density lipoprotein." [GOC:rl] +synonym: "high density lipoprotein mediated signalling" EXACT [] +is_a: GO:0055095 ! lipoprotein mediated signaling +relationship: part_of GO:0055099 ! response to high density lipoprotein stimulus + +[Term] +id: GO:0055098 +name: response to low density lipoprotein stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low density lipoprotein stimulus." [GOC:rl] +is_a: GO:0055094 ! response to lipoprotein stimulus + +[Term] +id: GO:0055099 +name: response to high density lipoprotein stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein stimulus." [GOC:rl] +is_a: GO:0055094 ! response to lipoprotein stimulus + +[Term] +id: GO:0055100 +name: adiponectin binding +namespace: molecular_function +def: "Interacting selectively with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:rl, PMID:15210937] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0055101 +name: glycerophospholipase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:rl] +is_a: GO:0004859 ! phospholipase inhibitor activity + +[Term] +id: GO:0055102 +name: lipase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:rl] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0055103 +name: ligase regulator activity +namespace: molecular_function +def: "Modulates the activity of a ligase." [GOC:rl] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0055104 +name: ligase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a ligase." [GOC:rl] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0055105 +name: ubiquitin-protein ligase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a ubiquitin-protein ligase." [GOC:rl] +is_a: GO:0055104 ! ligase inhibitor activity +is_a: GO:0055106 ! ubiquitin-protein ligase regulator activity + +[Term] +id: GO:0055106 +name: ubiquitin-protein ligase regulator activity +namespace: molecular_function +def: "Modulates the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:rl] +is_a: GO:0055103 ! ligase regulator activity + +[Term] +id: GO:0055107 +name: Golgi to secretory granule transport +namespace: biological_process +def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:jid, http://cancerweb.ncl.ac.uk] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0055108 +name: Golgi to transport vesicle transport +namespace: biological_process +def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0055109 +name: invagination involved in gastrulation with mouth forming second +namespace: biological_process +def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055110 +name: involution involved in gastrulation with mouth forming second +namespace: biological_process +def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055111 +name: ingression involved in gastrulation with mouth forming second +namespace: biological_process +def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055112 +name: delamination involved in gastrulation with mouth forming second +namespace: biological_process +def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0060232 ! delamination +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055113 +name: epiboly involved in gastrulation with mouth forming second +namespace: biological_process +def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055114 +name: oxidation reduction +namespace: biological_process +def: "The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons." [GOC:dl, GOC:ed, GOC:jid, GOC:jm, GOC:mlg, GOC:rh] +subset: gosubset_prok +synonym: "electron transport process" EXACT systematic_synonym [] +synonym: "oxidoreductase process" EXACT systematic_synonym [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0055115 +name: diapause +namespace: biological_process +def: "A neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0055116 +name: reproductive diapause +namespace: biological_process +def: "A form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid] +is_a: GO:0055115 ! diapause + +[Term] +id: GO:0055117 +name: regulation of cardiac muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ed] +is_a: GO:0006942 ! regulation of striated muscle contraction +is_a: GO:0008016 ! regulation of heart contraction +relationship: regulates GO:0060048 ! cardiac muscle contraction + +[Term] +id: GO:0055118 +name: negative regulation of cardiac muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ed] +is_a: GO:0045988 ! negative regulation of striated muscle contraction +is_a: GO:0055117 ! regulation of cardiac muscle contraction +relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction + +[Term] +id: GO:0055119 +name: relaxation of cardiac muscle +namespace: biological_process +def: "The process whereby the extent of cardiac muscle contraction is reduced." [GOC:ed] +is_a: GO:0055118 ! negative regulation of cardiac muscle contraction + +[Term] +id: GO:0055120 +name: striated muscle dense body +namespace: cellular_component +def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481] +is_a: GO:0044449 ! contractile fiber part + +[Term] +id: GO:0055121 +name: response to high fluence blue light stimulus by blue high-fluence system +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red] +synonym: "response to high fluence blue light" BROAD [] +synonym: "response to high fluence blue light by bhf system" RELATED [] +is_a: GO:0009637 ! response to blue light +is_a: GO:0009644 ! response to high light intensity + +[Term] +id: GO:0055122 +name: response to very low light intensity stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0060001 +name: minus-end directed microfilament motor activity +namespace: molecular_function +def: "Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] +synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph] +synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph] +synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph] +is_a: GO:0000146 ! microfilament motor activity + +[Term] +id: GO:0060002 +name: plus-end directed microfilament motor activity +namespace: molecular_function +def: "Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers." [GOC:dph, PMID:10519557] +synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph] +synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph] +synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph] +is_a: GO:0000146 ! microfilament motor activity + +[Term] +id: GO:0060003 +name: copper ion export +namespace: biological_process +def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph] +synonym: "copper export" EXACT [GOC:dph] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0034220 ! transmembrane ion transport + +[Term] +id: GO:0060004 +name: reflex +namespace: biological_process +def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:087797099] +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0060005 +name: vestibular reflex +namespace: biological_process +def: "A reflex process by which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060006 +name: angular vestibuloocular reflex +namespace: biological_process +def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] +is_a: GO:0060005 ! vestibular reflex + +[Term] +id: GO:0060007 +name: linear vestibuloocular reflex +namespace: biological_process +def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] +is_a: GO:0060005 ! vestibular reflex + +[Term] +id: GO:0060008 +name: Sertoli cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0060009 +name: Sertoli cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060008 ! Sertoli cell differentiation + +[Term] +id: GO:0060010 +name: Sertoli cell fate commitment +namespace: biological_process +def: "The process by which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0060008 ! Sertoli cell differentiation + +[Term] +id: GO:0060011 +name: Sertoli cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] +is_a: GO:0008283 ! cell proliferation +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0060012 +name: synaptic transmission, glycinergic +namespace: biological_process +def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dph] +synonym: "glycinergic synaptic transmission" EXACT [] +is_a: GO:0007270 ! nerve-nerve synaptic transmission + +[Term] +id: GO:0060013 +name: righting reflex +namespace: biological_process +def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460] +synonym: "righting response" EXACT [GOC:dph] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060014 +name: granulosa cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0060015 +name: granulosa cell fate commitment +namespace: biological_process +def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0060014 ! granulosa cell differentiation + +[Term] +id: GO:0060016 +name: granulosa cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060014 ! granulosa cell differentiation + +[Term] +id: GO:0060017 +name: parathyroid gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0060018 +name: astrocyte fate commitment +namespace: biological_process +def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph] +is_a: GO:0021781 ! glial cell fate commitment +relationship: part_of GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0060019 +name: radial glial cell differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0060020 +name: Bergmann glial cell differentiation +namespace: biological_process +def: "The process whereby neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] +is_a: GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0060021 +name: palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "palatum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0060022 +name: hard palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "palatum durum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060021 ! palate development + +[Term] +id: GO:0060023 +name: soft palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "palatum molle development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "velum palatum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060021 ! palate development + +[Term] +id: GO:0060024 +name: rhythmic synaptic transmission +namespace: biological_process +def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph] +is_a: GO:0050804 ! regulation of synaptic transmission + +[Term] +id: GO:0060025 +name: regulation of synaptic activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] +is_a: GO:0050804 ! regulation of synaptic transmission +relationship: part_of GO:0050803 ! regulation of synapse structure and activity + +[Term] +id: GO:0060026 +name: convergent extension +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:df, GOC:dph, PMID:12062082] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0060027 +name: convergent extension involved in gastrulation +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082] +is_a: GO:0060026 ! convergent extension +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0060028 +name: convergent extension involved in axis elongation +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082] +is_a: GO:0060026 ! convergent extension + +[Term] +id: GO:0060029 +name: convergent extension involved in organogenesis +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082] +is_a: GO:0060026 ! convergent extension +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0060030 +name: dorsal convergence +namespace: biological_process +def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:df, GOC:dph, PMID:12062082] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:0060031 +name: mediolateral intercalation +namespace: biological_process +def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:df, GOC:dph, PMID:12062082] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:0060032 +name: notochord regression +namespace: biological_process +def: "The developmental process by which the stucture of the notochord is destroyed in an embryo." [GOC:dph] +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0048570 ! notochord morphogenesis + +[Term] +id: GO:0060033 +name: anatomical structure regression +namespace: biological_process +def: "The developmental process by which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0060034 +name: notochord cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030903 ! notochord development + +[Term] +id: GO:0060035 +name: notochord cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060034 ! notochord cell differentiation + +[Term] +id: GO:0060036 +name: notochord cell vacuolation +namespace: biological_process +def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477] +is_a: GO:0007033 ! vacuole organization +relationship: part_of GO:0060035 ! notochord cell development + +[Term] +id: GO:0060037 +name: pharyngeal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] +is_a: GO:0048731 ! system development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0060038 +name: cardiac muscle cell proliferation +namespace: biological_process +def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rh1, PMID:11161571] +synonym: "cardiac myocyte proliferation" EXACT [] +synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] +synonym: "heart muscle cell proliferation" EXACT [] +is_a: GO:0014855 ! striated muscle cell proliferation +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0060039 +name: pericardium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rh1, PMID:15138308, PMID:16376438] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0060040 +name: retinal bipolar neuron differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:bf, GOC:dph] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060041 +name: retina development in camera-type eye +namespace: biological_process +alt_id: GO:0002073 +def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, GOC:mtg_transport, ISBN:0815340729] +synonym: "retina development (sensu Mammalia)" EXACT [] +synonym: "retina development in camera-style eye" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0060042 +name: retina morphogenesis in camera-type eye +namespace: biological_process +def: "The process by which the anatomical structure of the retina is generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf, GOC:dph, GOC:mtg_sensu] +synonym: "retina morphogenesis in camera-style eye" EXACT [] +synonym: "retinogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048593 ! camera-type eye morphogenesis +relationship: part_of GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:0060043 +name: regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rh] +synonym: "regulation of heart muscle cell proliferation" EXACT [] +is_a: GO:0042127 ! regulation of cell proliferation +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0060038 ! cardiac muscle cell proliferation + +[Term] +id: GO:0060044 +name: negative regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rh] +synonym: "negative regulation of heart muscle cell proliferation" EXACT [] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation +relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation + +[Term] +id: GO:0060045 +name: positive regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rh] +synonym: "positive regulation of heart muscle cell proliferation" RELATED [] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation +relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation + +[Term] +id: GO:0060046 +name: regulation of acrosome reaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +relationship: regulates GO:0007340 ! acrosome reaction + +[Term] +id: GO:0060047 +name: heart contraction +namespace: biological_process +def: "The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] +synonym: "cardiac contraction" RELATED [] +synonym: "heart beating" EXACT [] +is_a: GO:0003015 ! heart process +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0060048 +name: cardiac muscle contraction +namespace: biological_process +def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] +synonym: "heart muscle contraction" EXACT [] +is_a: GO:0006941 ! striated muscle contraction +relationship: part_of GO:0060047 ! heart contraction + +[Term] +id: GO:0060049 +name: regulation of protein amino acid glycosylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein amino acid glycosylation. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0060050 +name: positive regulation of protein amino acid glycosylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:0060049 ! regulation of protein amino acid glycosylation +relationship: positively_regulates GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0060051 +name: negative regulation of protein amino acid glycosylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:0060049 ! regulation of protein amino acid glycosylation +relationship: negatively_regulates GO:0006486 ! protein amino acid glycosylation + +[Term] +id: GO:0060052 +name: neurofilament cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph] +synonym: "neurofilament cytoskeleton organization and biogenesis" EXACT [] +is_a: GO:0045104 ! intermediate filament cytoskeleton organization + +[Term] +id: GO:0060053 +name: neurofilament cytoskeleton +namespace: cellular_component +def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph] +is_a: GO:0045111 ! intermediate filament cytoskeleton + +[Term] +id: GO:0060054 +name: positive regulation of epithelial cell proliferation involved in wound healing +namespace: biological_process +def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0060055 +name: angiogenesis involved in wound healing +namespace: biological_process +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218] +is_a: GO:0001525 ! angiogenesis +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0060056 +name: mammary gland involution +namespace: biological_process +def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0060057 +name: apoptosis involved in mammary gland involution +namespace: biological_process +def: "The form of programmed cell death that triggers the activity of proteolytic caspases, whose actions dismantle the mammary epithelial cells resulting in their death." [GOC:dph] +is_a: GO:0006915 ! apoptosis +relationship: part_of GO:0060056 ! mammary gland involution + +[Term] +id: GO:0060058 +name: positive regulation of apoptosis involved in mammary gland involution +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptosis of mammary epithelial cells during mammary gland involution." [GOC:dph, PMID:15282149] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: positively_regulates GO:0060057 ! apoptosis involved in mammary gland involution + +[Term] +id: GO:0060059 +name: embryonic retina morphogenesis in camera-type eye +namespace: biological_process +def: "The process by which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage . Morphogenesis pertains to the creation of form." [GOC:dgh, GOC:dph] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060060 +name: post-embryonic retina morphogenesis in camera-type eye +namespace: biological_process +def: "The process by which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage . Morphogenesis pertains to the creation of form." [GOC:dgh, GOC:dph] +is_a: GO:0009886 ! post-embryonic morphogenesis +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060061 +name: Spemann organizer formation +namespace: biological_process +def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, GOC:ref] +synonym: "Spemann's organizer formation" EXACT [] +synonym: "Spemann-Mangold organizer formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0031128 ! induction + +[Term] +id: GO:0060062 +name: Spemann organizer formation at the dorsal lip of the blastopore +namespace: biological_process +def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883] +comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish. +synonym: "Spemann organizer formation (Sensu amphibia)" RELATED [] +synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT [] +synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT [] +is_a: GO:0060061 ! Spemann organizer formation + +[Term] +id: GO:0060063 +name: Spemann organizer formation at the embryonic shield +namespace: biological_process +def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883] +comment: Occurs in Teleost fish. +synonym: "Spemann organizer formation (Sensu Teleost)" EXACT [] +synonym: "Spemann's organizer formation at the embryonic shield" EXACT [] +synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT [] +is_a: GO:0060061 ! Spemann organizer formation + +[Term] +id: GO:0060064 +name: Spemann organizer formation at the anterior end of the primitive streak +namespace: biological_process +def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883] +comment: Occurs in reptiles, birds and mammals. +synonym: "Spemann organizer formation in amniotes" RELATED [] +synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT [] +synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED [] +is_a: GO:0060061 ! Spemann organizer formation + +[Term] +id: GO:0060065 +name: uterus development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ec] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060066 +name: fallopian tube development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the fallopian tubes over time, from their formation to the mature structures." [GOC:dph, GOC:ec] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060067 +name: cervix development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ec] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060068 +name: vagina development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ec] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060069 +name: Wnt receptor signaling pathway, regulating spindle positioning +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397] +synonym: "non-canonical Wnt signaling pathway" BROAD [] +synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT [] +is_a: GO:0016055 ! Wnt receptor signaling pathway + +[Term] +id: GO:0060070 +name: Wnt receptor signaling pathway through beta-catenin +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397] +synonym: "canonical Wnt signaling pathway" EXACT [] +synonym: "frizzled-1 receptor signaling pathway" NARROW [] +synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT [] +is_a: GO:0016055 ! Wnt receptor signaling pathway + +[Term] +id: GO:0060071 +name: Wnt receptor signaling pathway, planar cell polarity pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [] +synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf] +synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rh] +is_a: GO:0016055 ! Wnt receptor signaling pathway +relationship: part_of GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0060072 +name: large conductance calcium-activated potassium channel activity +namespace: molecular_function +alt_id: GO:0022895 +def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074] +synonym: "BK calcium-activated potassium channel activity" EXACT [] +synonym: "BK channel activity" RELATED [] +synonym: "BK KCa channels" EXACT [] +synonym: "large conductance KCa channels" EXACT [] +is_a: GO:0015269 ! calcium-activated potassium channel activity + +[Term] +id: GO:0060073 +name: micturition +namespace: biological_process +def: "The regulation of body fluids process by which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph] +synonym: "urination" EXACT [] +synonym: "urine voiding" EXACT [] +is_a: GO:0003014 ! renal system process +is_a: GO:0007588 ! excretion + +[Term] +id: GO:0060074 +name: synapse maturation +namespace: biological_process +def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef] +synonym: "synaptic maturation" EXACT [] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0060075 +name: regulation of resting membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433] +synonym: "regulation of resting potential" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0060076 +name: excitatory synapse +namespace: cellular_component +def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0060077 +name: inhibitory synapse +namespace: cellular_component +def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0060078 +name: regulation of postsynaptic membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron." [GOC:dph, GOC:ef] +is_a: GO:0042391 ! regulation of membrane potential +relationship: part_of GO:0007268 ! synaptic transmission + +[Term] +id: GO:0060079 +name: regulation of excitatory postsynaptic membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef] +synonym: "EPSP" RELATED [] +is_a: GO:0051899 ! membrane depolarization +is_a: GO:0060078 ! regulation of postsynaptic membrane potential + +[Term] +id: GO:0060080 +name: regulation of inhibitory postsynaptic membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of the inhibitory postsynaptic potential (IPSP) which is a temporay decrease in postsynaptic potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef] +synonym: "IPSP" RELATED [] +is_a: GO:0060078 ! regulation of postsynaptic membrane potential +is_a: GO:0060081 ! membrane hyperpolarization + +[Term] +id: GO:0060081 +name: membrane hyperpolarization +namespace: biological_process +def: "The process in which membrane potential changes in the hyperpolarizing direction from the resting potential, usually from negative to more negative." [GOC:dph] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0060082 +name: eye blink reflex +namespace: biological_process +def: "The reflex process by which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208] +synonym: "nictitating membrane reflex" EXACT [] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060083 +name: smooth muscle contraction involved in micturition +namespace: biological_process +def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347] +synonym: "smooth muscle contraction involved in urination" RELATED [] +synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph] +is_a: GO:0014832 ! urinary bladder smooth muscle contraction +relationship: part_of GO:0060073 ! micturition + +[Term] +id: GO:0060084 +name: synaptic transmission involved in micturition +namespace: biological_process +def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] +synonym: "synaptic transmission involved in urination" RELATED [] +is_a: GO:0007274 ! neuromuscular synaptic transmission +relationship: part_of GO:0060073 ! micturition + +[Term] +id: GO:0060085 +name: smooth muscle relaxation of the bladder outlet +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] +synonym: "synaptic transmission involved in urination" EXACT [] +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +relationship: part_of GO:0060073 ! micturition + +[Term] +id: GO:0060086 +name: circadian temperature homeostasis +namespace: biological_process +def: "Any homeostatic process by which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb] +synonym: "circadian regulation of body temperature" RELATED [] +synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001659 ! temperature homeostasis +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0060087 +name: relaxation of vascular smooth muscle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GOC:dph, PMID:15867178] +synonym: "vascular smooth muscle relaxation" EXACT [] +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +relationship: part_of GO:0042311 ! vasodilation + +[Term] +id: GO:0060088 +name: auditory receptor cell stereocilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835] +synonym: "auditory receptor cell stereocilium organization and biogenesis" EXACT [] +synonym: "stereocilium organisation and biogenesis" EXACT [] +is_a: GO:0060122 ! inner ear receptor stereocilium organization +relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis + +[Term] +id: GO:0060089 +name: molecular transducer activity +namespace: molecular_function +def: "The molecular function that accepts an input of one form and creates an output of a different form." [GOC:mtg_MIT_16mar07] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0060090 +name: molecular adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07] +subset: goslim_pir +subset: gosubset_prok +is_a: GO:0005488 ! binding + +[Term] +id: GO:0060091 +name: kinocilium +namespace: cellular_component +def: "An immotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:dph, PMID:15882574] +is_a: GO:0031513 ! nonmotile primary cilium +is_a: GO:0044422 ! organelle part +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0032421 ! stereocilium bundle + +[Term] +id: GO:0060092 +name: regulation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +is_a: GO:0050804 ! regulation of synaptic transmission +relationship: regulates GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0060093 +name: negative regulation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +synonym: "negative regulation of glycinergic synaptic transmission" EXACT [] +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic +relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0060094 +name: positive regulation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +synonym: "positive regulation of glycinergic synaptic transmission" EXACT [] +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic +relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0060095 +name: zinc potentiation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT [] +is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic + +[Term] +id: GO:0060096 +name: serotonin secretion, neurotransmission +namespace: biological_process +def: "The regulated release of serotonin by a cell or group of cells, in which released serotonin acts as a neurotransmitter." [GOC:dph] +is_a: GO:0001820 ! serotonin secretion +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0060097 +name: cytoskeletal rearrangement involved in phagocytosis, engulfment +namespace: biological_process +def: "The assembly and arrangement of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0007010 ! cytoskeleton organization +relationship: part_of GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060098 +name: membrane reorganization involved in phagocytosis, engulfment +namespace: biological_process +def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0007009 ! plasma membrane organization +relationship: part_of GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060099 +name: regulation of phagocytosis, engulfment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0050764 ! regulation of phagocytosis +relationship: regulates GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060100 +name: positive regulation of phagocytosis, engulfment +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0050766 ! positive regulation of phagocytosis +is_a: GO:0060099 ! regulation of phagocytosis, engulfment +relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060101 +name: negative regulation of phagocytosis, engulfment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0050765 ! negative regulation of phagocytosis +is_a: GO:0060099 ! regulation of phagocytosis, engulfment +relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060102 +name: collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] +synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0005578 ! proteinaceous extracellular matrix + +[Term] +id: GO:0060103 +name: collagen and cuticulin-based cuticle extracellular matrix part +namespace: cellular_component +def: "Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph] +is_a: GO:0044420 ! extracellular matrix part + +[Term] +id: GO:0060104 +name: surface coat of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "surface coat of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] +synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060105 +name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "epicuticle of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] +synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060106 +name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "cortical layer of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] +synonym: "cortical layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060107 +name: annuli extracellular matrix +namespace: cellular_component +def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "annulae" RELATED [] +synonym: "annular rings" RELATED [] +synonym: "annule(s)" RELATED [] +synonym: "annulus" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060108 +name: annular furrow extracellular matrix +namespace: cellular_component +def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060109 +name: medial layer of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "medial layer struts" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060110 +name: basal layer of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "basal layer of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] +synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060111 +name: alae of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "alae of collagen and cuticulin-based cuticle extracellular matrix (sensu Nematoda)" RELATED [] +synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060112 +name: generation of ovulation cycle rhythm +namespace: biological_process +def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph] +synonym: "generation of estrus cycle rhythm" EXACT [] +synonym: "generation of menstrual cycle rhythm" RELATED [] +synonym: "generation of oestrus cycle rhythm" EXACT [] +is_a: GO:0022602 ! ovulation cycle process + +[Term] +id: GO:0060113 +name: inner ear receptor cell differentiation +namespace: biological_process +def: "The process whereby relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph] +synonym: "inner ear hair cell differentiation" EXACT [] +is_a: GO:0042490 ! mechanoreceptor differentiation +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0060114 +name: vestibular receptor cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph] +synonym: "vestibular hair cell differentiation" EXACT [] +is_a: GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0060115 +name: vestibular receptor cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become a vestibular receptor cell." [GOC:dph] +synonym: "vestibular hair cell fate commitment" EXACT [] +is_a: GO:0060120 ! inner ear receptor cell fate commitment +relationship: part_of GO:0060114 ! vestibular receptor cell differentiation + +[Term] +id: GO:0060116 +name: vestibular receptor cell morphogenesis +namespace: biological_process +def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb] +synonym: "vestibular hair cell morphogenesis" EXACT [] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0060118 ! vestibular receptor cell development + +[Term] +id: GO:0060117 +name: auditory receptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +synonym: "auditory hair cell development" EXACT [] +is_a: GO:0060119 ! inner ear receptor cell development +relationship: part_of GO:0042491 ! auditory receptor cell differentiation + +[Term] +id: GO:0060118 +name: vestibular receptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +synonym: "vestibular hair cell development" EXACT [] +is_a: GO:0060119 ! inner ear receptor cell development +relationship: part_of GO:0060114 ! vestibular receptor cell differentiation + +[Term] +id: GO:0060119 +name: inner ear receptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +synonym: "inner ear hair cell development" EXACT [] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0060120 +name: inner ear receptor cell fate commitment +namespace: biological_process +def: "The process by which a cell becomes committed to become an inner ear receptor cell." [GOC:dph] +synonym: "inner ear hair cell fate commitment" EXACT [] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0060121 +name: vestibular receptor cell stereocilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph] +synonym: "vestibular hair cell stereocilium organization and biogenesis" EXACT [] +synonym: "vestibular receptor cell stereocilium organization and biogenesis" EXACT [] +is_a: GO:0060122 ! inner ear receptor stereocilium organization +relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis + +[Term] +id: GO:0060122 +name: inner ear receptor stereocilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph] +synonym: "inner ear hair cell receptor stereocilium organization" EXACT [] +synonym: "inner ear receptor stereocilium organization and biogenesis" EXACT [] +is_a: GO:0030030 ! cell projection organization +relationship: part_of GO:0060119 ! inner ear receptor cell development + +[Term] +id: GO:0060123 +name: regulation of growth hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0030252 ! growth hormone secretion + +[Term] +id: GO:0060124 +name: positive regulation of growth hormone secretion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph] +is_a: GO:0002793 ! positive regulation of peptide secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0060123 ! regulation of growth hormone secretion +relationship: positively_regulates GO:0030252 ! growth hormone secretion + +[Term] +id: GO:0060125 +name: negative regulation of growth hormone secretion +namespace: biological_process +def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph] +is_a: GO:0002792 ! negative regulation of peptide secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0060123 ! regulation of growth hormone secretion +relationship: negatively_regulates GO:0030252 ! growth hormone secretion + +[Term] +id: GO:0060126 +name: somatotropin secreting cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] +synonym: "growth hormone secreting cell differentiation" RELATED [] +synonym: "somatotrope differentiation" RELATED [] +synonym: "somatotroph differentiation" RELATED [] +synonym: "somatotrophin secreting cell differentiation" EXACT [] +synonym: "somatotropic cell differentiation" RELATED [] +synonym: "somatrophic cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060127 +name: prolactin secreting cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] +synonym: "epsilon-acidophil differentiation" EXACT [] +synonym: "lactotrope differentiation" EXACT [] +synonym: "lactotroph differentiation" EXACT [] +synonym: "lactotropic cell differentiation" EXACT [] +synonym: "mammotrope differentiation" EXACT [] +synonym: "mammotroph differentiation" EXACT [] +synonym: "mammotrophic cell differentiation" EXACT [] +synonym: "mammotropic cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060128 +name: adrenocorticotropin hormone secreting cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a adrenocorticotropic hormone secreting cell. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin." [GOC:dph] +synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT [] +synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph] +synonym: "corticotrope differentiation" EXACT [] +synonym: "corticotroph differentiation" EXACT [] +synonym: "corticotrophin hormone secreting cell differentiation" RELATED [] +synonym: "corticotropin hormone secreting cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060129 +name: thyroid stimulating hormone secreting cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell, acquires specialized structural and/or functional features of a adrenocorticotropi hormone secreting cell. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph] +synonym: "beta-basophil differentiation" EXACT [] +synonym: "thyrotrope differentiation" EXACT [] +synonym: "thyrotroph differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060130 +name: thyroid stimulating hormone secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a thyroid stimulating hormone secreting cell over time, from its formation to the mature structure. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph] +synonym: "beta-basophil development" EXACT [] +synonym: "thyrotrope development" EXACT [] +synonym: "thyrotroph development" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060129 ! thyroid stimulating hormone secreting cell differentiation + +[Term] +id: GO:0060131 +name: adrenocorticotropin hormone secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a adrenocorticotropic hormone secreting cell over time, from its formation to the mature structure. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin." [GOC:dph] +synonym: "adrenocorticotrophic hormone secreting cell development" EXACT [] +synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph] +synonym: "corticotrope development" EXACT [] +synonym: "corticotroph development" RELATED [] +synonym: "corticotrophin hormone secreting cell development" RELATED [] +synonym: "corticotropin hormone secreting cell development" RELATED [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060128 ! adrenocorticotropin hormone secreting cell differentiation + +[Term] +id: GO:0060132 +name: prolactin secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] +synonym: "epsilon-acidophil development" EXACT [] +synonym: "lactotrope development" EXACT [] +synonym: "lactotroph development" EXACT [] +synonym: "lactotropic cell development" EXACT [] +synonym: "mammotrope development" EXACT [] +synonym: "mammotroph development" EXACT [] +synonym: "mammotrophic cell development" EXACT [] +synonym: "mammotropic cell development" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060127 ! prolactin secreting cell differentiation + +[Term] +id: GO:0060133 +name: somatotropin secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] +synonym: "growth hormone secreting cell development" RELATED [] +synonym: "somatotrope development" RELATED [] +synonym: "somatotroph development" RELATED [] +synonym: "somatotrophin secreting cell development" EXACT [] +synonym: "somatotropic cell development" EXACT [] +synonym: "somatrophic cell development" RELATED [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation + +[Term] +id: GO:0060134 +name: prepulse inhibition +namespace: biological_process +def: "The process by which a startle magnitude is reduced when the startling stimulus is preceeded by a low-intensity prepulse." [GOC:dph, PMID:10341260] +synonym: "PPI" RELATED [] +synonym: "pre-pulse inhibition" EXACT [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +relationship: part_of GO:0001964 ! startle response + +[Term] +id: GO:0060135 +name: maternal process involved in pregnancy +namespace: biological_process +def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007565 ! female pregnancy + +[Term] +id: GO:0060136 +name: embryonic process involved in female pregnancy +namespace: biological_process +def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007565 ! female pregnancy +relationship: part_of GO:0009792 ! embryonic development ending in birth or egg hatching + +[Term] +id: GO:0060137 +name: maternal process involved in parturition +namespace: biological_process +def: "A reproductive process occurring in the mother that results in birth." [GOC:dph] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007567 ! parturition + +[Term] +id: GO:0060138 +name: fetal process involved in parturition +namespace: biological_process +def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0007567 ! parturition +relationship: part_of GO:0009792 ! embryonic development ending in birth or egg hatching + +[Term] +id: GO:0060139 +name: positive regulation of apoptosis by virus +namespace: biological_process +def: "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptosis." [GOC:dph] +is_a: GO:0019048 ! virus-host interaction +is_a: GO:0043065 ! positive regulation of apoptosis +relationship: part_of GO:0006926 ! virus-infected cell apoptosis + +[Term] +id: GO:0060140 +name: syncytium formation by plasma membrane fusion of virally targeted cells +namespace: biological_process +def: "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0000768 ! syncytium formation by plasma membrane fusion +relationship: part_of GO:0006948 ! induction by virus of cell-cell fusion in host + +[Term] +id: GO:0060141 +name: positive regulation of syncytium formation by virus +namespace: biological_process +def: "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0019054 ! modification by virus of host cellular process +is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion +relationship: part_of GO:0006948 ! induction by virus of cell-cell fusion in host + +[Term] +id: GO:0060142 +name: regulation of syncytium formation by plasma membrane fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0060143 +name: positive regulation of syncytium formation by plasma membrane fusion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0060144 +name: host cellular processes involved in virus induced gene silencing +namespace: biological_process +def: "The set of cellular processes occurring in the host cell that contribute to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0009616 ! virus induced gene silencing + +[Term] +id: GO:0060145 +name: viral gene silencing in virus induced gene silencing +namespace: biological_process +def: "The posttranscriptional gene silencing of viral genes after viral infection." [GOC:dph] +is_a: GO:0016441 ! posttranscriptional gene silencing +relationship: part_of GO:0009616 ! virus induced gene silencing + +[Term] +id: GO:0060146 +name: host gene silencing in virus induced gene silencing +namespace: biological_process +def: "The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph] +is_a: GO:0016441 ! posttranscriptional gene silencing +relationship: part_of GO:0009616 ! virus induced gene silencing + +[Term] +id: GO:0060147 +name: regulation of posttranscriptional gene silencing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] +is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +relationship: regulates GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0060148 +name: positive regulation of posttranscriptional gene silencing +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] +is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0060149 +name: negative regulation of posttranscriptional gene silencing +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] +is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process +is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0060150 +name: viral triggering of virus induced gene silencing +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression of both viral genes and host homologues to those genes by a posttranscriptional mechanism in a virally infected cell." [GOC:dph] +is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing +relationship: part_of GO:0009616 ! virus induced gene silencing + +[Term] +id: GO:0060151 +name: peroxisome localization +namespace: biological_process +def: "Any process by which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0060152 +name: microtubule-based peroxisome localization +namespace: biological_process +def: "The microtubule-based process by which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] +is_a: GO:0007017 ! microtubule-based process +relationship: part_of GO:0060151 ! peroxisome localization + +[Term] +id: GO:0060153 +name: viral process regulating host cell cycle +namespace: biological_process +def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph] +is_a: GO:0051726 ! regulation of cell cycle +relationship: part_of GO:0019055 ! modification by virus of host cell cycle regulation + +[Term] +id: GO:0060154 +name: cellular process regulating host cell cycle in response to virus +namespace: biological_process +def: "Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph] +is_a: GO:0009615 ! response to virus +is_a: GO:0051726 ! regulation of cell cycle +relationship: part_of GO:0019055 ! modification by virus of host cell cycle regulation + +[Term] +id: GO:0060155 +name: platelet dense granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378] +synonym: "bull's eye body organization and biogenesis" RELATED [] +synonym: "platelet dense body organization and biogenesis" RELATED [] +synonym: "platelet dense granule organization and biogenesis" EXACT [] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0060156 +name: milk ejection +namespace: biological_process +def: "An automatic response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:dph, GOC:st] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060157 +name: urinary bladder development +namespace: biological_process +def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln] +is_a: GO:0048513 ! organ development +relationship: part_of GO:0001655 ! urogenital system development + +[Term] +id: GO:0060158 +name: dopamine receptor, phospholipase C activating pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, PMID:12675914] +is_a: GO:0007200 ! G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) +is_a: GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060159 +name: regulation of dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +relationship: regulates GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060160 +name: negative regulation of dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway +relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060161 +name: positive regulation of dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway +relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060162 +name: negative regulation of dopamine receptor, phospholipase C activating pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, PMID:15016423] +is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway +relationship: negatively_regulates GO:0060158 ! dopamine receptor, phospholipase C activating pathway + +[Term] +id: GO:0060163 +name: subpallium neuron fate commitment +namespace: biological_process +def: "The process whereby in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] +synonym: "subpallium neuronal precursor fate commitment" RELATED [] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0060164 +name: regulation of timing of neuron differentiation +namespace: biological_process +def: "The process controlling the timing and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph] +is_a: GO:0045664 ! regulation of neuron differentiation +is_a: GO:0048505 ! regulation of timing of cell differentiation + +[Term] +id: GO:0060165 +name: regulation of timing of subpallium neuron differentiation +namespace: biological_process +def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] +is_a: GO:0060164 ! regulation of timing of neuron differentiation +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0060166 +name: olfactory pit development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043584 ! nose development + +[Term] +id: GO:0060167 +name: regulation of adenosine receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +relationship: regulates GO:0001973 ! adenosine receptor signaling pathway + +[Term] +id: GO:0060168 +name: positive regulation of adenosine receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway +relationship: positively_regulates GO:0001973 ! adenosine receptor signaling pathway + +[Term] +id: GO:0060169 +name: negative regulation of adenosine receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway +relationship: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway + +[Term] +id: GO:0060170 +name: cilium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a cilium." [GOC:dph, GOC:rh] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0044441 ! cilium part + +[Term] +id: GO:0060171 +name: stereocilium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rh] +is_a: GO:0031528 ! microvillus membrane +is_a: GO:0044422 ! organelle part +is_a: GO:0044424 ! intracellular part +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0060172 +name: spindle astral microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph] +is_a: GO:0007019 ! microtubule depolymerization +is_a: GO:0030953 ! spindle astral microtubule organization + +[Term] +id: GO:0060173 +name: limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] +synonym: "limb bud development" NARROW [GOC:dph] +is_a: GO:0048736 ! appendage development + +[Term] +id: GO:0060174 +name: limb bud formation +namespace: biological_process +def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field ends when a limb bud is recognizable." [GOC:dgh, GOC:dph] +synonym: "limb formation" EXACT [] +synonym: "limbbud formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0060175 +name: brain-derived neurotrophic factor receptor activity +namespace: molecular_function +def: "Combining with brain-derived neurotrophic factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph] +synonym: "BDNF receptor activity" RELATED [GOC:dph] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +is_a: GO:0005030 ! neurotrophin receptor activity + +[Term] +id: GO:0060176 +name: regulation of aggregation involved in sorocarp development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb] +is_a: GO:0031156 ! regulation of sorocarp development +relationship: regulates GO:0031152 ! aggregation involved in sorocarp development + +[Term] +id: GO:0060177 +name: regulation of angiotensin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb] +synonym: "regulation of angiotensin metabolism" EXACT [] +is_a: GO:0051246 ! regulation of protein metabolic process + +[Term] +id: GO:0060178 +name: regulation of exocyst localization +namespace: biological_process +def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse." [GOC:dph, GOC:tb] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0051601 ! exocyst localization + +[Term] +id: GO:0060179 +name: male mating behavior +namespace: biological_process +def: "The specific actions or reactions of a male organism that are associated with reproduction." [GOC:dph, GOC:tb] +is_a: GO:0033057 ! reproductive behavior in a multicellular organism +relationship: part_of GO:0007617 ! mating behavior + +[Term] +id: GO:0060180 +name: female mating behavior +namespace: biological_process +def: "The specific actions or reactions of a female organism that are associated with reproduction." [GOC:dph, GOC:tb] +is_a: GO:0033057 ! reproductive behavior in a multicellular organism +relationship: part_of GO:0007617 ! mating behavior + +[Term] +id: GO:0060181 +name: female receptivity +namespace: biological_process +def: "The biological process that controls the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:tb] +is_a: GO:0060180 ! female mating behavior + +[Term] +id: GO:0060182 +name: apelin receptor activity +namespace: molecular_function +def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph] +is_a: GO:0008528 ! peptide receptor activity, G-protein coupled + +[Term] +id: GO:0060183 +name: apelin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph] +is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway + +[Term] +id: GO:0060184 +name: cell cycle switching +namespace: biological_process +def: "The process by which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0060185 +name: outer ear unfolding +namespace: biological_process +def: "The opening and spreading out of the outer ear." [GOC:dph] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0042473 ! outer ear morphogenesis + +[Term] +id: GO:0060186 +name: outer ear emergence +namespace: biological_process +def: "The growth of the outer ear." [GOC:dph] +synonym: "ear elevation" RELATED [GOC:dph] +synonym: "ear extroversion" RELATED [GOC:dph] +synonym: "outer ear growth" RELATED [GOC:dph] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0042473 ! outer ear morphogenesis + +[Term] +id: GO:0060187 +name: cell pole +namespace: cellular_component +def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] +is_a: GO:0044464 ! cell part + +[Term] +id: GO:0060188 +name: regulation of protein desumoylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0016926 ! protein desumoylation + +[Term] +id: GO:0060189 +name: positive regulation of protein desumoylation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0060188 ! regulation of protein desumoylation +relationship: positively_regulates GO:0016926 ! protein desumoylation + +[Term] +id: GO:0060190 +name: negative regulation of protein desumoylation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0060188 ! regulation of protein desumoylation +relationship: negatively_regulates GO:0016926 ! protein desumoylation + +[Term] +id: GO:0060191 +name: regulation of lipase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] +subset: gosubset_prok +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0060192 +name: negative regulation of lipase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0060193 +name: positive regulation of lipase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0060194 +name: regulation of antisense RNA transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +relationship: regulates GO:0009300 ! antisense RNA transcription + +[Term] +id: GO:0060195 +name: negative regulation of antisense RNA transcription +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] +is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent +is_a: GO:0060194 ! regulation of antisense RNA transcription +relationship: negatively_regulates GO:0009300 ! antisense RNA transcription + +[Term] +id: GO:0060196 +name: positive regulation of antisense RNA transcription +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] +is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent +is_a: GO:0060194 ! regulation of antisense RNA transcription +relationship: positively_regulates GO:0009300 ! antisense RNA transcription + +[Term] +id: GO:0060197 +name: cloacal septation +namespace: biological_process +def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0001655 ! urogenital system development +relationship: part_of GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0060198 +name: clathrin sculpted vesicle +namespace: cellular_component +def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph] +is_a: GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0060199 +name: clathrin sculpted glutamate transport vesicle +namespace: cellular_component +def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0060198 ! clathrin sculpted vesicle + +[Term] +id: GO:0060200 +name: clathrin sculpted acetylcholine transport vesicle +namespace: cellular_component +def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0060198 ! clathrin sculpted vesicle + +[Term] +id: GO:0060201 +name: clathrin sculpted acetylcholine transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin sculpted acetylcholine transport vesicle." [GOC:dph] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030665 ! clathrin coated vesicle membrane +relationship: part_of GO:0060200 ! clathrin sculpted acetylcholine transport vesicle + +[Term] +id: GO:0060202 +name: clathrin sculpted acetylcholine transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin sculpted acetylcholine transport vesicle." [GOC:dph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0060200 ! clathrin sculpted acetylcholine transport vesicle + +[Term] +id: GO:0060203 +name: clathrin sculpted glutamate transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin sculpted glutamate transport vesicle." [GOC:dph] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030665 ! clathrin coated vesicle membrane +relationship: part_of GO:0060199 ! clathrin sculpted glutamate transport vesicle + +[Term] +id: GO:0060204 +name: clathrin sculpted glutamate transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin sculpted glutamate transport vesicle." [GOC:dph] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0060199 ! clathrin sculpted glutamate transport vesicle + +[Term] +id: GO:0060205 +name: cytoplasmic membrane-bounded vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle." [GOC:dph] +synonym: "cytoplasmic membrane-enclosed vesicle lumen" EXACT [] +is_a: GO:0031983 ! vesicle lumen +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle + +[Term] +id: GO:0060206 +name: estrous cycle phase +namespace: biological_process +def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph] +is_a: GO:0022602 ! ovulation cycle process + +[Term] +id: GO:0060207 +name: diestrus +namespace: biological_process +def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060208 +name: proestrus +namespace: biological_process +def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060209 +name: estrus +namespace: biological_process +def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +synonym: "oestrus" EXACT [] +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060210 +name: metestrus +namespace: biological_process +def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060211 +name: regulation of nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] +synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED [] +synonym: "regulation of mRNA deadenylation" RELATED [] +synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening + +[Term] +id: GO:0060212 +name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] +synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing +is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening +relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening + +[Term] +id: GO:0060213 +name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] +synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing +is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening +relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening + +[Term] +id: GO:0060214 +name: endocardium formation +namespace: biological_process +def: "Formation of the inner endothelial cell layer of the heart, which connects the heart to the vascular system." [GOC:dph, GOC:rf, PMID:17722983] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0060215 +name: primitive hemopoiesis +namespace: biological_process +def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] +synonym: "primitive haematopoiesis" EXACT [] +synonym: "primitive haemopoiesis" EXACT [] +synonym: "primitive hematopoiesis" RELATED [] +is_a: GO:0035162 ! embryonic hemopoiesis + +[Term] +id: GO:0060216 +name: definitive hemopoiesis +namespace: biological_process +def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] +synonym: "definitive haematopoiesis" RELATED [] +synonym: "definitive haemopoiesis" EXACT [] +synonym: "definitive hematopoiesis" EXACT [] +is_a: GO:0030097 ! hemopoiesis + +[Term] +id: GO:0060217 +name: hemangioblast cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, GOC:ref, PMID:15378083, PMID:9670018] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0060215 ! primitive hemopoiesis + +[Term] +id: GO:0060218 +name: hemopoietic stem cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a hemopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:dph, PMID:15378083] +synonym: "haematopoietic stem cell differentiation" EXACT [] +synonym: "haemopoietic stem cell differentiation" EXACT [] +synonym: "hematopoietic stem cell differentiation" EXACT [] +is_a: GO:0048863 ! stem cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0060219 +name: camera-type eye photoreceptor cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:dph] +is_a: GO:0001754 ! eye photoreceptor cell differentiation +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060220 +name: camera-type eye photoreceptor cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph] +is_a: GO:0042706 ! eye photoreceptor cell fate commitment +relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation + +[Term] +id: GO:0060221 +name: retinal rod cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] +is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation + +[Term] +id: GO:0060222 +name: regulation of retinal cone cell fate commitment +namespace: biological_process +def: "Any process that modulates the process whereby a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0060223 +name: retinal rod cell fate commitment +namespace: biological_process +def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] +is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment +relationship: part_of GO:0060221 ! retinal rod cell differentiation + +[Term] +id: GO:0060224 +name: regulation of retinal rod cell fate commitment +namespace: biological_process +def: "Any process that modulates the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0060223 ! retinal rod cell fate commitment + +[Term] +id: GO:0060225 +name: positive regulation of retinal rod cell fate commitment +namespace: biological_process +def: "Any process that increases the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation +is_a: GO:0060224 ! regulation of retinal rod cell fate commitment +relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment + +[Term] +id: GO:0060226 +name: negative regulation of retinal cone cell fate commitment +namespace: biological_process +def: "Any process that increases the process whereby a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation +is_a: GO:0060222 ! regulation of retinal cone cell fate commitment +relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0060227 +name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment + +[Term] +id: GO:0060228 +name: phosphatidylcholine-sterol O-acyltransferase activator activity +namespace: molecular_function +def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:dph, GOC:tb, PMID:4335615] +synonym: "LCAT activator activity" NARROW [GOC:tb] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0060229 +name: lipase activator activity +namespace: molecular_function +def: "Increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:dph, GOC:tb] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0060230 +name: lipoprotein lipase activator activity +namespace: molecular_function +def: "Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:dph, GOC:tb, PMID:10727238] +is_a: GO:0060229 ! lipase activator activity + +[Term] +id: GO:0060231 +name: mesenchymal to epithelial transition +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:dph] +synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0002064 ! epithelial cell development + +[Term] +id: GO:0060232 +name: delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process by which a cell or sheet of cells splits off of an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion + +[Term] +id: GO:0060233 +name: oenocyte delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process by which an oenocyte splits off of an existing epithelial sheet." [GOC:dph] +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0060234 +name: neuroblast delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process by which a neuroblast slits off of a neurectodermal sheet." [GOC:dph] +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0060235 +name: lens induction in camera-type eye +namespace: biological_process +def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437] +is_a: GO:0031128 ! induction +relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye + +[Term] +id: GO:0060236 +name: regulation of mitotic spindle organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the microtubule spindle during a mitotic cell cycle." [GOC:dph, GOC:tb] +synonym: "regulation of mitotic spindle organization and biogenesis" EXACT [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0060237 +name: regulation of fungal-type cell wall organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb] +synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0031505 ! fungal-type cell wall organization + +[Term] +id: GO:0060238 +name: regulation of signal transduction during conjugation with cellular fusion +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0032005 ! signal transduction during conjugation with cellular fusion + +[Term] +id: GO:0060239 +name: positive regulation of signal transduction during conjugation with cellular fusion +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0060238 ! regulation of signal transduction during conjugation with cellular fusion +relationship: positively_regulates GO:0032005 ! signal transduction during conjugation with cellular fusion + +[Term] +id: GO:0060240 +name: negative regulation of signal transduction during conjugation with cellular fusion +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0060238 ! regulation of signal transduction during conjugation with cellular fusion +relationship: negatively_regulates GO:0032005 ! signal transduction during conjugation with cellular fusion + +[Term] +id: GO:0060241 +name: lysozyme inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a lysozyme, an enzyme that hydrolyses the beta- (1,4) glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan." [GOC:dph] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0060242 +name: contact inhibition +namespace: biological_process +def: "The cellular process by which cells stop growing or dividing in response to increased cell density." [GOC:dph, PMID:17376520] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0060243 +name: negative regulation of cell growth involved in contact inhibition +namespace: biological_process +def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph] +is_a: GO:0030308 ! negative regulation of cell growth +relationship: part_of GO:0060242 ! contact inhibition + +[Term] +id: GO:0060244 +name: negative regulation of cell proliferation involved in contact inhibition +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph] +is_a: GO:0008285 ! negative regulation of cell proliferation +relationship: part_of GO:0060242 ! contact inhibition + +[Term] +id: GO:0060245 +name: detection of cell density +namespace: biological_process +def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph] +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0060246 +name: detection of cell density by contact stimulus +namespace: biological_process +def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal." [GOC:dph] +is_a: GO:0060245 ! detection of cell density + +[Term] +id: GO:0060247 +name: detection of cell density by secreted molecule +namespace: biological_process +def: "The series of events in which information about the density of cells in a population is received by the detection of a secreted molecule and is converted into a molecular signal." [GOC:dph] +is_a: GO:0060245 ! detection of cell density + +[Term] +id: GO:0060248 +name: detection of cell density by contact stimulus involved in contact inhibition +namespace: biological_process +def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph] +is_a: GO:0060246 ! detection of cell density by contact stimulus +relationship: part_of GO:0060242 ! contact inhibition + +[Term] +id: GO:0060249 +name: anatomical structure homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] +synonym: "anatomical structure maintenance" EXACT [GOC:dph] +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0060250 +name: germ-line stem-cell niche maintenance +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal equilibrium within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] +synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph] +synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph] +synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph] +synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph] +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0060251 +name: regulation of glial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] +is_a: GO:0014013 ! regulation of gliogenesis +is_a: GO:0042127 ! regulation of cell proliferation +relationship: regulates GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0060252 +name: positive regulation of glial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0008284 ! positive regulation of cell proliferation +is_a: GO:0014015 ! positive regulation of gliogenesis +is_a: GO:0060251 ! regulation of glial cell proliferation +relationship: positively_regulates GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0060253 +name: negative regulation of glial cell proliferation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0008285 ! negative regulation of cell proliferation +is_a: GO:0014014 ! negative regulation of gliogenesis +is_a: GO:0060251 ! regulation of glial cell proliferation +relationship: negatively_regulates GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0060254 +name: regulation of N-terminal protein palmitoylation +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of the covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +relationship: regulates GO:0006500 ! N-terminal protein palmitoylation + +[Term] +id: GO:0060255 +name: regulation of macromolecule metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +subset: gosubset_prok +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0060256 +name: regulation of flocculation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] +is_a: GO:0043900 ! regulation of multi-organism process +relationship: regulates GO:0000128 ! flocculation + +[Term] +id: GO:0060257 +name: negative regulation of flocculation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0060256 ! regulation of flocculation +relationship: negatively_regulates GO:0000128 ! flocculation + +[Term] +id: GO:0060258 +name: negative regulation of filamentous growth +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] +is_a: GO:0010570 ! regulation of filamentous growth +is_a: GO:0045926 ! negative regulation of growth +relationship: negatively_regulates GO:0030447 ! filamentous growth + +[Term] +id: GO:0060259 +name: regulation of feeding behavior +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:dph, GOC:tb] +synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb] +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0007631 ! feeding behavior + +[Term] +id: GO:0060260 +name: regulation of transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from the RNA polymerase II promoter." [GOC:dph, GOC:tb] +is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0060261 +name: positive regulation of transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from the RNA polymerase II promoter." [GOC:dph, GOC:tb] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter +relationship: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0060262 +name: negative regulation of N-terminal protein palmitoylation +namespace: biological_process +def: "Any process that decreases the rate frequency or extent of the covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process +is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation +relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation + +[Term] +id: GO:0060263 +name: regulation of respiratory burst +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0045730 ! respiratory burst + +[Term] +id: GO:0060264 +name: regulation of respiratory burst during acute inflammatory response +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0060263 ! regulation of respiratory burst +relationship: regulates GO:0002536 ! respiratory burst during acute inflammatory response + +[Term] +id: GO:0060265 +name: positive regulation of respiratory burst during acute inflammatory response +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0060264 ! regulation of respiratory burst during acute inflammatory response +is_a: GO:0060267 ! positive regulation of respiratory burst +relationship: positively_regulates GO:0002536 ! respiratory burst during acute inflammatory response + +[Term] +id: GO:0060266 +name: negative regulation of respiratory burst during acute inflammatory response +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0060264 ! regulation of respiratory burst during acute inflammatory response +is_a: GO:0060268 ! negative regulation of respiratory burst +relationship: negatively_regulates GO:0002536 ! respiratory burst during acute inflammatory response + +[Term] +id: GO:0060267 +name: positive regulation of respiratory burst +namespace: biological_process +def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0060263 ! regulation of respiratory burst +relationship: positively_regulates GO:0045730 ! respiratory burst + +[Term] +id: GO:0060268 +name: negative regulation of respiratory burst +namespace: biological_process +def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0060263 ! regulation of respiratory burst +relationship: negatively_regulates GO:0045730 ! respiratory burst + +[Term] +id: GO:0060269 +name: centripetally migrating follicle cell migration +namespace: biological_process +def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph] +is_a: GO:0007297 ! ovarian follicle cell migration + +[Term] +id: GO:0060270 +name: main body follicle cell migration +namespace: biological_process +def: "The ovarian follicle cell migration process in which follicle cells migrate posteeriorly to form a columnar epithelium over the oocyte." [GOC:dph] +is_a: GO:0007297 ! ovarian follicle cell migration + +[Term] +id: GO:0060271 +name: cilium morphogenesis +namespace: biological_process +def: "A process that is carried out at the cellular level and by which the structure of a cilium is organized. Morphogenesis pertains to the creation of form." [GOC:dph] +synonym: "cilium organization" RELATED [GOC:dph] +is_a: GO:0048858 ! cell projection morphogenesis + +[Term] +id: GO:0060272 +name: embryonic skeletal joint morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A joint is the connecting structure between the bones of the skeleton. Morphogenesis pertains to the creation of form." [GOC:dph] +is_a: GO:0048704 ! embryonic skeletal system morphogenesis + +[Term] +id: GO:0060273 +name: crying behavior +namespace: biological_process +def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0060274 +name: maintenance of stationary phase +namespace: biological_process +def: "The homeostatic process by which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrientsor a build-up of toxic substances in the environment." [GOC:dph] +is_a: GO:0048874 ! homeostasis of number of cells in a free-living population + +[Term] +id: GO:0060275 +name: maintenance of stationary phase in response to starvation +namespace: biological_process +def: "The homeostatic process by which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph] +is_a: GO:0042594 ! response to starvation +is_a: GO:0060274 ! maintenance of stationary phase + +[Term] +id: GO:0060276 +name: maintenance of stationary phase in response to toxin +namespace: biological_process +def: "The homeostatic process by which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph] +is_a: GO:0009636 ! response to toxin +is_a: GO:0060274 ! maintenance of stationary phase + +[Term] +id: GO:0060277 +name: negative regulation of transcription during G1 phase of mitotic cell cycle +namespace: biological_process +def: "Any process that stop, prevents or decreases transcription during the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb] +synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000114 ! regulation of transcription during G1 phase of mitotic cell cycle +is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0060278 +name: regulation of ovulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0030728 ! ovulation + +[Term] +id: GO:0060279 +name: positive regulation of ovulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0060278 ! regulation of ovulation +relationship: positively_regulates GO:0030728 ! ovulation + +[Term] +id: GO:0060280 +name: negative regulation of ovulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060278 ! regulation of ovulation +relationship: negatively_regulates GO:0030728 ! ovulation + +[Term] +id: GO:0060281 +name: regulation of oocyte development +namespace: biological_process +def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060282 +name: positive regulation of oocyte development +namespace: biological_process +def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0060281 ! regulation of oocyte development +relationship: positively_regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060283 +name: negative regulation of oocyte development +namespace: biological_process +def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0060281 ! regulation of oocyte development +relationship: negatively_regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060284 +name: regulation of cell development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0048468 ! cell development + +[Term] +id: GO:0060285 +name: ciliary cell motility +namespace: biological_process +def: "Cell motility due to the motion of one or more cilia." [GOC:dgh, GOC:dph, GOC:mlg] +is_a: GO:0001539 ! ciliary or flagellar motility + +[Term] +id: GO:0060286 +name: flagellar cell motility +namespace: biological_process +def: "Cell motility due to the motion of one or more flagellum." [GOC:dgh, GOC:dph, GOC:mlg] +is_a: GO:0001539 ! ciliary or flagellar motility + +[Term] +id: GO:0060287 +name: cilium motion involved in determination of left/right asymmetry +namespace: biological_process +def: "The movement of cilia of epithelial cells reasulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:mlg] +synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT [] +is_a: GO:0006928 ! cell motion +relationship: part_of GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:0060288 +name: formation of a compartment boundary +namespace: biological_process +def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] +synonym: " compartment boundary formation" EXACT [] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0007386 ! compartment specification + +[Term] +id: GO:0060289 +name: compartment boundary maintenance +namespace: biological_process +def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] +is_a: GO:0001894 ! tissue homeostasis +relationship: part_of GO:0007386 ! compartment specification + +[Term] +id: GO:0060290 +name: transdifferentiation +namespace: biological_process +def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0060291 +name: long-term synaptic potentiation +namespace: biological_process +def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] +synonym: "long-term potentiation" BROAD [GOC:dph] +synonym: "LTP" RELATED [GOC:dph] +is_a: GO:0048167 ! regulation of synaptic plasticity +is_a: GO:0050806 ! positive regulation of synaptic transmission + +[Term] +id: GO:0060292 +name: long term synaptic depression +namespace: biological_process +def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] +synonym: "long term depression" BROAD [GOC:dph] +synonym: "LTD" RELATED [GOC:dph] +is_a: GO:0048167 ! regulation of synaptic plasticity +is_a: GO:0050805 ! negative regulation of synaptic transmission + +[Term] +id: GO:0060293 +name: germ plasm +namespace: cellular_component +def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph] +is_a: GO:0045495 ! pole plasm + +[Term] +id: GO:0060294 +name: cilium movement involved in ciliary motility +namespace: biological_process +def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:dph, GOC:tb] +is_a: GO:0007018 ! microtubule-based movement +relationship: part_of GO:0060285 ! ciliary cell motility + +[Term] +id: GO:0060295 +name: regulation of cilium movement involved in ciliary motility +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:dph, GOC:tb] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0032886 ! regulation of microtubule-based process +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0051270 ! regulation of cell motion +relationship: regulates GO:0060294 ! cilium movement involved in ciliary motility + +[Term] +id: GO:0060296 +name: regulation of cilium beat frequency involved in ciliary motility +namespace: biological_process +def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:dph, GOC:tb] +is_a: GO:0060295 ! regulation of cilium movement involved in ciliary motility +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0060297 +name: regulation of sarcomere organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:dph, GOC:tb] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0045214 ! sarcomere organization + +[Term] +id: GO:0060298 +name: positive regulation of sarcomere organization +namespace: biological_process +def: "Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:dph, GOC:tb] +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0060297 ! regulation of sarcomere organization +relationship: positively_regulates GO:0045214 ! sarcomere organization + +[Term] +id: GO:0060299 +name: negative regulation of sarcomere organization +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:dph, GOC:tb] +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:0060297 ! regulation of sarcomere organization +relationship: negatively_regulates GO:0045214 ! sarcomere organization + +[Term] +id: GO:0060300 +name: regulation of cytokine activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:dph, GOC:tb] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0060301 +name: positive regulation of cytokine activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:dph, GOC:tb] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:0060300 ! regulation of cytokine activity + +[Term] +id: GO:0060302 +name: negative regulation of cytokine activity +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:dph, GOC:tb] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:0060300 ! regulation of cytokine activity + +[Term] +id: GO:0060303 +name: regulation of nucleosome density +namespace: biological_process +def: "Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb] +is_a: GO:0034728 ! nucleosome organization +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0060304 +name: regulation of phosphoinosotide dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives." [GOC:dph, GOC:tb] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0046856 ! phosphoinositide dephosphorylation + +[Term] +id: GO:0060305 +name: regulation of cell diameter +namespace: biological_process +def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb] +is_a: GO:0008361 ! regulation of cell size + +[Term] +id: GO:0060306 +name: regulation of membrane repolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:dph, GOC:tb] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0060307 +name: regulation of ventricular cardiomyocyte membrane repolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb] +synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0055117 ! regulation of cardiac muscle contraction +is_a: GO:0060306 ! regulation of membrane repolarization + +[Term] +id: GO:0060308 +name: GTP cyclohydrolase I regulator activity +namespace: molecular_function +def: "Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0060309 +name: elastin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and cross linked to form elastic fibres that are found in connective tissue." [GOC:dph, GOC:tb] +synonym: "elastin breakdown" EXACT [] +synonym: "elastin catabolism" EXACT [] +synonym: "elastin degradation" EXACT [] +is_a: GO:0006516 ! glycoprotein catabolic process +is_a: GO:0051541 ! elastin metabolic process + +[Term] +id: GO:0060310 +name: regulation of elastin catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:dph, GOC:tb] +synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0060309 ! elastin catabolic process + +[Term] +id: GO:0060311 +name: negative regulation of elastin catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:dph, GOC:tb] +synonym: "down-regulation of elastin catabolic process" EXACT [] +synonym: "negative regulation of elastin breakdown" EXACT [] +synonym: "negative regulation of elastin catabolism" EXACT [] +synonym: "negative regulation of elastin degradation" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0060310 ! regulation of elastin catabolic process +relationship: negatively_regulates GO:0060309 ! elastin catabolic process + +[Term] +id: GO:0060312 +name: regulation of blood vessel remodeling +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0001974 ! blood vessel remodeling + +[Term] +id: GO:0060313 +name: negative regulation of blood vessel remodeling +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:dph, GOC:tb] +synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0060312 ! regulation of blood vessel remodeling +relationship: negatively_regulates GO:0001974 ! blood vessel remodeling + +[Term] +id: GO:0060314 +name: regulation of ryanodine-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0060315 +name: negative regulation of ryanodine-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity + +[Term] +id: GO:0060316 +name: positive regulation of ryanodine-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity + +[Term] +id: GO:0060317 +name: cardiac epithelial to mesenchymal transition +namespace: biological_process +def: "A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:16314491, PMID:1996351] +synonym: "heart epithelial to mesenchymal transition" EXACT [] +is_a: GO:0001837 ! epithelial to mesenchymal transition +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0060318 +name: definitive erythrocyte differentiation +namespace: biological_process +def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph] +synonym: "definitive erythropoiesis" EXACT [] +is_a: GO:0030218 ! erythrocyte differentiation +relationship: part_of GO:0060216 ! definitive hemopoiesis + +[Term] +id: GO:0060319 +name: primitive erythrocyte differentiation +namespace: biological_process +def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:adiehl, GOC:dph] +synonym: "primitive erythropoiesis" EXACT [GOC:adiehl, GOC:dph] +is_a: GO:0030218 ! erythrocyte differentiation +relationship: part_of GO:0060215 ! primitive hemopoiesis + +[Term] +id: GO:0060320 +name: rejection of self pollen +namespace: biological_process +def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma." [GOC:dph, GOC:tb] +is_a: GO:0048544 ! recognition of pollen + +[Term] +id: GO:0060321 +name: acceptance of pollen +namespace: biological_process +def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma." [GOC:dph, GOC:tb] +synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb] +synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb] +is_a: GO:0048544 ! recognition of pollen + +[Term] +id: GO:0060322 +name: head development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0060323 +name: head morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0010171 ! body morphogenesis +relationship: part_of GO:0060322 ! head development + +[Term] +id: GO:0060324 +name: face development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060322 ! head development + +[Term] +id: GO:0060325 +name: face morphogenesis +namespace: biological_process +def: "The process by which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060323 ! head morphogenesis +relationship: part_of GO:0060324 ! face development + +[Term] +id: GO:0060326 +name: cell chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0060327 +name: cytoplasmic actin-based contraction involved in cell motility +namespace: biological_process +def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph] +is_a: GO:0030048 ! actin filament-based movement +relationship: part_of GO:0048870 ! cell motility + +[Term] +id: GO:0060328 +name: cytoplasmic actin-based contraction involved in forward cell motility +namespace: biological_process +def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph] +synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED [] +is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility + +[Term] +id: GO:0060329 +name: cytoplasmic actin-based contraction involved in rearward cell motility +namespace: biological_process +def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph] +synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED [] +is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility + +[Term] +id: GO:0060330 +name: regulation of response to interferon-gamma +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] +synonym: "regulation of response to gamma-interferon" RELATED [] +synonym: "regulation of response to immune interferon" EXACT [] +synonym: "regulation of response to type II IFN" EXACT [] +synonym: "regulation of response to type II interferon" EXACT [] +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0034341 ! response to interferon-gamma + +[Term] +id: GO:0060331 +name: negative regulation of response to interferon-gamma +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] +synonym: "negative regulation of response to gamma-interferon" RELATED [] +synonym: "negative regulation of response to immune interferon" EXACT [] +synonym: "negative regulation of response to type II IFN" EXACT [] +synonym: "negative regulation of response to type II interferon" EXACT [] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0060330 ! regulation of response to interferon-gamma +relationship: negatively_regulates GO:0034341 ! response to interferon-gamma + +[Term] +id: GO:0060332 +name: positive regulation of response to interferon-gamma +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] +synonym: "positive regulation of response to gamma-interferon" RELATED [] +synonym: "positive regulation of response to immune interferon" EXACT [] +synonym: "positive regulation of response to type II IFN" EXACT [] +synonym: "positive regulation of response to type II interferon" EXACT [] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0060330 ! regulation of response to interferon-gamma +relationship: positively_regulates GO:0034341 ! response to interferon-gamma + +[Term] +id: GO:0060333 +name: interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "A series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:add, GOC:dph] +synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph] +synonym: "immune interferon signaling pathway" EXACT [GOC:dph] +synonym: "type II IFN-mediated signaling pathway" RELATED [] +synonym: "type II interferon-mediated signaling pathway" EXACT [GOC:dph] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0060334 +name: regulation of interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] +synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] +synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph] +synonym: "regulation of type II IFN-mediated signaling pathway" EXACT [GOC:dph] +synonym: "regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +relationship: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway + +[Term] +id: GO:0060335 +name: positive regulation of interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] +synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] +synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] +synonym: "positive regulation of type II IFN-mediated pathway" EXACT [GOC:dph] +synonym: "positive regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph] +is_a: GO:0001961 ! positive regulation of cytokine mediated signaling pathway +is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway +relationship: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway + +[Term] +id: GO:0060336 +name: negative regulation of interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] +synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] +synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] +synonym: "negative regulation of type II IFN-mediated signaling pathway" EXACT [GOC:dph] +synonym: "negative regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph] +is_a: GO:0001960 ! negative regulation of cytokine mediated signaling pathway +is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway +relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway + +[Term] +id: GO:0060337 +name: type I interferon-mediated signaling pathway +namespace: biological_process +def: "A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0060338 +name: regulation of type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +relationship: regulates GO:0060337 ! type I interferon-mediated signaling pathway + +[Term] +id: GO:0060339 +name: negative regulation of type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] +is_a: GO:0001960 ! negative regulation of cytokine mediated signaling pathway +is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway +relationship: negatively_regulates GO:0060337 ! type I interferon-mediated signaling pathway + +[Term] +id: GO:0060340 +name: positive regulation of type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] +is_a: GO:0001961 ! positive regulation of cytokine mediated signaling pathway +is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway +relationship: positively_regulates GO:0060337 ! type I interferon-mediated signaling pathway + +[Term] +id: GO:0060341 +name: regulation of cellular localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process by which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051641 ! cellular localization + +[Term] +id: GO:0060342 +name: photoreceptor inner segment membrane +namespace: cellular_component +def: "The membrane surrounding the outer segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0001917 ! photoreceptor inner segment + +[Term] +id: GO:0060343 +name: trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] +synonym: "trabecula biogenesis" RELATED [GOC:dph] +synonym: "trabeculation" EXACT [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0009887 ! organ morphogenesis + +[Term] +id: GO:0060344 +name: liver trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "liver trabecula biogenesis" RELATED [] +synonym: "liver trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0060345 +name: spleen trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "spleen trabecula biogenesis" RELATED [GOC:dph] +synonym: "spleen trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0048536 ! spleen development + +[Term] +id: GO:0060346 +name: bone trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "bone trabecula biogenesis" RELATED [GOC:dph] +synonym: "bone trabeculation" EXACT [GOC:dph] +synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph] +synonym: "skeletal trabecula formation" EXACT [GOC:dph] +synonym: "skeletal trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0048705 ! skeletal system morphogenesis + +[Term] +id: GO:0060347 +name: heart trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "cardiac trabecula formation" EXACT [GOC:dph] +synonym: "cardiac trabeculation" EXACT [GOC:dph] +synonym: "heart trabecula biogenesis" RELATED [GOC:dph] +synonym: "heart trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0060348 +name: bone development +namespace: biological_process +def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001501 ! skeletal system development + +[Term] +id: GO:0060349 +name: bone morphogenesis +namespace: biological_process +def: "The process by which bones are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0060350 +name: endochondral bone morphogenesis +namespace: biological_process +def: "The process by which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] +is_a: GO:0060349 ! bone morphogenesis + +[Term] +id: GO:0060351 +name: cartilage development involved in endochondral bone morphogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] +is_a: GO:0051216 ! cartilage development +relationship: part_of GO:0060350 ! endochondral bone morphogenesis + +[Term] +id: GO:0060352 +name: cell adhesion molecule production +namespace: biological_process +def: "The appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:rl] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0060353 +name: regulation of cell adhesion molecule production +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:rl] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0060352 ! cell adhesion molecule production + +[Term] +id: GO:0060354 +name: negative regulation of cell adhesion molecule production +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:rl] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0060353 ! regulation of cell adhesion molecule production +relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production + +[Term] +id: GO:0060355 +name: positive regulation of cell adhesion molecule production +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:rl] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0060353 ! regulation of cell adhesion molecule production +relationship: positively_regulates GO:0060352 ! cell adhesion molecule production + +[Term] +id: GO:0060356 +name: leucine import +namespace: biological_process +def: "The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "L-leucine import" NARROW [] +synonym: "L-leucine uptake" NARROW [] +synonym: "leucine uptake" EXACT [] +is_a: GO:0015820 ! leucine transport + +[Term] +id: GO:0060357 +name: regulation of leucine import +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0060356 ! leucine import + +[Term] +id: GO:0060358 +name: negative regulation of leucine import +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:0060357 ! regulation of leucine import +relationship: negatively_regulates GO:0060356 ! leucine import + +[Term] +id: GO:0060359 +name: response to ammonium ion +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0060360 +name: negative regulation of leucine import in response to ammonium ion +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT [] +is_a: GO:0060358 ! negative regulation of leucine import +is_a: GO:0060359 ! response to ammonium ion + +[Term] +id: GO:0060361 +name: flight +namespace: biological_process +def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] +is_a: GO:0040011 ! locomotion + +[Term] +id: GO:0060362 +name: flight involved in flight behavior +namespace: biological_process +def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph] +is_a: GO:0060361 ! flight +relationship: part_of GO:0007629 ! flight behavior + +[Term] +id: GO:0060363 +name: cranial suture morphogenesis +namespace: biological_process +def: "The process by which the cranial suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060349 ! bone morphogenesis + +[Term] +id: GO:0060364 +name: frontal suture morphogenesis +namespace: biological_process +def: "The process by which the frontal suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060365 +name: coronal suture morphogenesis +namespace: biological_process +def: "The process by which the coronal suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060366 +name: lambdoid suture morphogenesis +namespace: biological_process +def: "The process by which the lambdoid suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060367 +name: saggital suture morphogenesis +namespace: biological_process +def: "The process by which the saggital suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0065001 +name: specification of axis polarity +namespace: biological_process +def: "The pattern specification process by which the polarity of a body or organ axis is established and maintained." [GOC:mah] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0065002 +name: intracellular protein transmembrane transport +namespace: biological_process +def: "The directed movement of proteins in a cell, from one side of a membrane to another." [GOC:isa_complete] +synonym: "intracellular membrane translocation of a protein" EXACT [] +synonym: "intracellular protein transport across a membrane" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0065003 +name: macromolecular complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex." [GOC:jl] +subset: goslim_pir +subset: gosubset_prok +synonym: "macromolecule complex assembly" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0043933 ! macromolecular complex subunit organization + +[Term] +id: GO:0065004 +name: protein-DNA complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] +subset: gosubset_prok +is_a: GO:0034622 ! cellular macromolecular complex assembly + +[Term] +id: GO:0065005 +name: protein-lipid complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl] +subset: gosubset_prok +is_a: GO:0065003 ! macromolecular complex assembly + +[Term] +id: GO:0065006 +name: protein-carbohydrate complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and carbohydrates to form a protein-carbohydrate complex." [GOC:jl] +subset: gosubset_prok +is_a: GO:0065003 ! macromolecular complex assembly + +[Term] +id: GO:0065007 +name: biological regulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any biological process, quality or function." [GOC:isa_complete] +subset: goslim_pir +subset: gosubset_prok +synonym: "regulation" BROAD [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0065008 +name: regulation of biological quality +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:isa_complete] +subset: gosubset_prok +synonym: "regulation of biological attribute" EXACT [] +synonym: "regulation of biological characteristic" EXACT [] +is_a: GO:0065007 ! biological regulation + +[Term] +id: GO:0065009 +name: regulation of molecular function +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of molecular functions. Molecular functions are elemental biological activities occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] +subset: gosubset_prok +synonym: "regulation of a molecular function" EXACT [] +is_a: GO:0065007 ! biological regulation + +[Term] +id: GO:0065010 +name: extracellular membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] +synonym: "extracellular membrane-enclosed organelle" EXACT [] +is_a: GO:0043227 ! membrane-bounded organelle +is_a: GO:0043230 ! extracellular organelle + +[Term] +id: GO:0070001 +name: aspartic-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0070002 +name: glutamic-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0070003 +name: threonine-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides + +[Term] +id: GO:0070004 +name: cysteine-type exopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE] +is_a: GO:0008234 ! cysteine-type peptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0070005 +name: cysteine-type aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +xref: EC:3.4.18 +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0070004 ! cysteine-type exopeptidase activity + +[Term] +id: GO:0070006 +name: metalloaminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0008235 ! metalloexopeptidase activity + +[Term] +id: GO:0070007 +name: glutamic-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0070002 ! glutamic-type peptidase activity + +[Term] +id: GO:0070008 +name: serine-type exopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE, ISBN:0716720094] +subset: gosubset_prok +xref: EC:3.4.21 +xref: Reactome:1683 +is_a: GO:0008236 ! serine-type peptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0070009 +name: serine-type aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0070008 ! serine-type exopeptidase activity + +[Term] +id: GO:0070010 +name: peptidase activity, acting on D-amino acid peptides +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070011 +name: peptidase activity, acting on L-amino acid peptides +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah] +subset: gosubset_prok +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070012 +name: oligopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070013 +name: intracellular organelle lumen +namespace: cellular_component +def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] +is_a: GO:0043233 ! organelle lumen +is_a: GO:0044446 ! intracellular organelle part + +[Term] +id: GO:0070014 +name: sucrase-isomaltase complex +namespace: cellular_component +def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777] +synonym: "oligo-1,6-glucosidase complex" RELATED [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0070015 +name: glycine decarboxylase complex +namespace: cellular_component +def: "A protein complex that possesses glycine dehydrogenase (decarboxylating) activity. The complex is a heterotetramer, with subunits referred to as H, P, L, and T." [MeSH:D05.500.562.452, PMID:3080433] +synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0070016 +name: armadillo repeat domain binding +namespace: molecular_function +def: "Interacting selectively with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation." [GOC:mah, GOC:vk, InterPro:IPR000225] +synonym: "Arm repeat domain binding" EXACT [] +synonym: "armadillo domain binding" EXACT [] +synonym: "armadillo repeat binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070017 +name: alphav-beta3 integrin-thrombospondin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219] +synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070018 +name: transforming growth factor beta type I receptor complex +namespace: cellular_component +def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [Reactome:REACT_7737] +synonym: "TGF-beta type I receptor complex" EXACT [] +synonym: "TGF-beta type I receptor dimer" EXACT [Reactome:REACT_7737] +is_a: GO:0070022 ! transforming growth factor beta receptor complex + +[Term] +id: GO:0070019 +name: transforming growth factor beta type II receptor complex +namespace: cellular_component +def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [Reactome:REACT_7415] +synonym: "TGF-beta type II receptor complex" EXACT [] +synonym: "TGF-beta type II receptor dimer" EXACT [Reactome:REACT_7415] +is_a: GO:0070022 ! transforming growth factor beta receptor complex + +[Term] +id: GO:0070020 +name: transforming growth factor beta1-type II receptor complex +namespace: cellular_component +def: "A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:REACT_7218] +subset: goslim_pir +synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT [] +synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:REACT_7218] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070021 +name: transforming growth factor beta1-type II receptor-type I receptor complex +namespace: cellular_component +def: "A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer." [Reactome:REACT_7425] +subset: goslim_pir +synonym: "TGF-beta 1:type II receptor:type I receptor complex" EXACT [Reactome:REACT_7425] +synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" EXACT [] +synonym: "TGF-beta1-type II receptor-type I receptor complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070022 +name: transforming growth factor beta receptor complex +namespace: cellular_component +def: "A dimeric receptor complex that binds transforming growth factor beta (TGF-beta); consists of two TGF-beta receptor monomers." [GOC:mah, Reactome:REACT_7415, Reactome:REACT_7737] +synonym: "TGF-beta receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0070023 +name: interleukin12-interleukin-12 receptor complex +namespace: cellular_component +def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991] +subset: goslim_pir +synonym: "IL12-IL12 receptor complex" EXACT [] +synonym: "IL12B-IL12RB1-IL12RB2 complex" RELATED [CORUM:2020] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070024 +name: CD19-Vav-PIK3R1 complex +namespace: cellular_component +def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218] +subset: goslim_pir +synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070025 +name: carbon monoxide binding +namespace: molecular_function +def: "Interacting selectively with carbon monoxide (CO)." [GOC:ecd] +subset: gosubset_prok +synonym: "CO binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0070026 +name: nitric oxide binding +namespace: molecular_function +def: "Interacting selectively with nitric oxide (NO)." [GOC:ecd] +subset: gosubset_prok +synonym: "nitrogen monoxide binding" EXACT [] +synonym: "nitrosyl binding" EXACT [ChEBI:16480] +synonym: "NO binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0070027 +name: carbon monoxide sensor activity +namespace: molecular_function +def: "Interacting selectively with and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd] +is_a: GO:0070025 ! carbon monoxide binding + +[Term] +id: GO:0070028 +name: regulation of transcription by carbon monoxide +namespace: biological_process +def: "Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd] +subset: gosubset_prok +synonym: "regulation of transcription by CO" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-dependent +is_a: GO:0034465 ! response to carbon monoxide + +[Term] +id: GO:0070029 +name: alphav-beta3 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190] +synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070030 +name: alphav-beta1 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829] +synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070031 +name: alphav-beta5 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829] +synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347] +is_a: GO:0043234 ! protein complex +is_a: GO:0044459 ! plasma membrane part + +[Term] +id: GO:0070032 +name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862] +synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795] +synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070033 +name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862] +synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796] +synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070034 +name: telomeric RNA binding +namespace: molecular_function +def: "Interacting selectively with the telomerase RNA template or to RNA complementary to it." [GOC:krc, PMID:16884717] +synonym: "telomeric RNA repeat binding" NARROW [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0070035 +name: purine NTP-dependent helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0004386 ! helicase activity + +[Term] +id: GO:0070036 +name: GTP-dependent helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah] +comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'. +subset: gosubset_prok +is_a: GO:0042623 ! ATPase activity, coupled +is_a: GO:0070035 ! purine NTP-dependent helicase activity + +[Term] +id: GO:0070037 +name: rRNA (pseudouridine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0070038 +name: rRNA (pseudouridine-N3-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity + +[Term] +id: GO:0070039 +name: rRNA (guanosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0070040 +name: rRNA (adenine-C2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0070041 +name: rRNA (uridine-C5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity + +[Term] +id: GO:0070042 +name: rRNA (uridine-N3-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity + +[Term] +id: GO:0070043 +name: rRNA (guanine-N7-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah] +subset: gosubset_prok +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0070044 +name: synaptobrevin 2-SNAP-25-syntaxin-1a complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] +synonym: "Snap25-Stx1a-Vamp2 complex" NARROW [] +synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070045 +name: synaptobrevin 2-SNAP-25-syntaxin-2 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851] +synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070046 +name: synaptobrevin 2-SNAP-25-syntaxin-3 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852] +synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070047 +name: synaptobrevin 2-SNAP-25-syntaxin-4 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853] +synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070048 +name: endobrevin-SNAP-25-syntaxin-1a complex +namespace: cellular_component +def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854] +synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070049 +name: endobrevin-SNAP-25-syntaxin-2 complex +namespace: cellular_component +def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855] +synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070050 +name: neuron maintenance +namespace: biological_process +def: "The cellular homeostatic process by which a neuron is preserved in a stable, differentiated functional and structural state." [GOC:mah] +is_a: GO:0019725 ! cellular homeostasis + +[Term] +id: GO:0070051 +name: fibrinogen binding +namespace: molecular_function +def: "Interacting selectively with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:mah, GOC:vk] +is_a: GO:0032403 ! protein complex binding + +[Term] +id: GO:0070052 +name: collagen V binding +namespace: molecular_function +def: "Interacting selectively with a type V collagen." [GOC:mah] +is_a: GO:0005518 ! collagen binding + +[Term] +id: GO:0070053 +name: thrombospondin receptor activity +namespace: molecular_function +def: "Combining with thrombospondin to initiate a change in cell activity." [GOC:vk] +is_a: GO:0004872 ! receptor activity + +[Term] +id: GO:0070054 +name: mRNA splicing, via endonucleolytic cleavage and ligation +namespace: biological_process +def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah] +comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. +subset: gosubset_prok +is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation +is_a: GO:0008033 ! tRNA processing + +[Term] +id: GO:0070055 +name: HAC1-type intron splice site recognition and cleavage +namespace: biological_process +def: "The process by which the tertiary structure of a HAC1 type intron is recognized, and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, PMID:10357823] +subset: gosubset_prok +is_a: GO:0006396 ! RNA processing +relationship: part_of GO:0070054 ! mRNA splicing, via endonucleolytic cleavage and ligation + +[Term] +id: GO:0070056 +name: prospore membrane leading edge +namespace: cellular_component +def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385] +synonym: "forespore membrane leading edge" EXACT [] +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0005628 ! prospore membrane + +[Term] +id: GO:0070057 +name: prospore membrane spindle pole body attachment site +namespace: cellular_component +def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385] +synonym: "forespore membrane SPB attachment site" EXACT [] +synonym: "forespore membrane spindle pole body attachment site" EXACT [] +synonym: "prospore membrane SPB attachment site" EXACT [] +is_a: GO:0044425 ! membrane part +relationship: part_of GO:0005628 ! prospore membrane + +[Term] +id: GO:0070058 +name: tRNA gene clustering +namespace: biological_process +def: "The process by which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579] +is_a: GO:0051276 ! chromosome organization +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0070059 +name: apoptosis in response to endoplasmic reticulum stress +namespace: biological_process +def: "Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, PMID:18701708] +synonym: "apoptosis in response to ER stress" EXACT [] +synonym: "apoptosis triggered by ER stress" EXACT [] +synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT [] +synonym: "ER stress-induced apoptosis" EXACT [] +is_a: GO:0006915 ! apoptosis + +[Term] +id: GO:0070060 +name: 'de novo' actin filament nucleation +namespace: biological_process +def: "The actin nucleation process by which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841] +synonym: "formin-mediated actin filament nucleation" NARROW [] +synonym: "unbranched actin filament nucleation" RELATED [] +is_a: GO:0045010 ! actin nucleation + +[Term] +id: GO:0070061 +name: fructose binding +namespace: molecular_function +def: "Interacting selectively with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [ChEBI:28757, GOC:mah] +subset: gosubset_prok +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0070062 +name: extracellular vesicular exosome +namespace: cellular_component +def: "A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:mah, PMID:15908444, PMID:17641064] +is_a: GO:0031988 ! membrane-bounded vesicle +is_a: GO:0065010 ! extracellular membrane-bounded organelle + +[Term] +id: GO:0070063 +name: RNA polymerase binding +namespace: molecular_function +def: "Interacting selectively with an RNA polymerase." [GOC:mah] +subset: gosubset_prok +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0070064 +name: proline-rich region binding +namespace: molecular_function +def: "Interacting selectively with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0070065 +name: cellubrevin-VAMP4-syntaxin-16 complex +namespace: cellular_component +def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770] +synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875] +synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070066 +name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex +namespace: cellular_component +def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770] +synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874] +synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070067 +name: syntaxin-6-syntaxin-16-Vti1a complex +namespace: cellular_component +def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070068 +name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex +namespace: cellular_component +def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] +synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877] +synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070069 +name: cytochrome complex +namespace: cellular_component +def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah] +is_a: GO:0043234 ! protein complex + +[Term] +id: GO:0070070 +name: proton-transporting V-type ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah] +synonym: "V-ATPase assembly" RELATED [] +synonym: "V-ATPase complex assembly" RELATED [] +is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly + +[Term] +id: GO:0070071 +name: proton-transporting two-sector ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah] +subset: gosubset_prok +is_a: GO:0043623 ! cellular protein complex assembly + +[Term] +id: GO:0070072 +name: vacuolar proton-transporting V-type ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:mah] +synonym: "V-ATPase assembly" BROAD [] +synonym: "V-ATPase complex assembly" BROAD [] +is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly + +[Term] +id: GO:0070073 +name: clustering of voltage-gated calcium channels +namespace: biological_process +def: "The process by which voltage-gated calcium channels become localized together in high densities." [GOC:sart, PMID:183853250] +synonym: "clustering of voltage gated calcium channels" EXACT [] +synonym: "clustering of voltage-dependent calcium channels" EXACT [] +synonym: "voltage-gated calcium channel clustering" EXACT [] +is_a: GO:0045161 ! neuronal ion channel clustering + +[Term] +id: GO:0070074 +name: mononeme +namespace: cellular_component +def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merosoites from schizonts." [PMID:18048320] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0070075 +name: tear secretion +namespace: biological_process +def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0070076 +name: histone lysine demethylation +namespace: biological_process +def: "The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah] +is_a: GO:0016577 ! histone demethylation + +[Term] +id: GO:0070077 +name: histone arginine demethylation +namespace: biological_process +def: "The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah] +is_a: GO:0016577 ! histone demethylation + +[Term] +id: GO:0070078 +name: histone H3-R2 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:vk] +is_a: GO:0070077 ! histone arginine demethylation + +[Term] +id: GO:0070079 +name: histone H4-R3 demethylation +namespace: biological_process +def: "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:vk] +is_a: GO:0070077 ! histone arginine demethylation + +[Term] +id: GO:0070080 +name: titin Z domain binding +namespace: molecular_function +def: "Interacting selectively with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129] +synonym: "Z repeat domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070081 +name: clathrin sculpted monoamine transport vesicle +namespace: cellular_component +def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0060198 ! clathrin sculpted vesicle + +[Term] +id: GO:0070082 +name: clathrin sculpted monoamine transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin sculpted monoamine transport vesicle." [GOC:mg2] +is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen +relationship: part_of GO:0070081 ! clathrin sculpted monoamine transport vesicle + +[Term] +id: GO:0070083 +name: clathrin sculpted monoamine transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin sculpted monoamine transport vesicle." [GOC:mg2] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030665 ! clathrin coated vesicle membrane +relationship: part_of GO:0070081 ! clathrin sculpted monoamine transport vesicle + +[Term] +id: GO:0070084 +name: protein initiator methionine removal +namespace: biological_process +def: "The post-translational protein modification process by which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah] +synonym: "removal of initiator methionine from protein" EXACT [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0070085 +name: glycosylation +namespace: biological_process +def: "The covalent attachment of a glycosyl residue to a substrate molecule." [GOC:mah] +is_a: GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0070086 +name: ubiquitin-dependent endocytosis +namespace: biological_process +def: "Endocytosis of a protein that requires the substrate to be modified by uniquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540] +synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp] +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0070087 +name: chromo shadow domain binding +namespace: molecular_function +def: "Interacting selectively with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:vk, InterPro:IPR008251, PMID:7667093] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070088 +name: PHA granule +namespace: cellular_component +def: "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerases and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expresssion PhaR." [GOC:mah, PMID:15762612] +synonym: "PHB granule" NARROW [] +synonym: "polyhydroxyalkanoate granule" EXACT [] +is_a: GO:0016234 ! inclusion body +is_a: GO:0044444 ! cytoplasmic part + +[Term] +id: GO:0070089 +name: chloride-activated potassium channel activity +namespace: molecular_function +def: "Catalysis of the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:kmv, GOC:mtg_transport] +subset: gosubset_prok +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0070090 +name: metaphase plate +namespace: cellular_component +def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah] +is_a: GO:0044424 ! intracellular part + +[Term] +id: GO:0070091 +name: glucagon secretion +namespace: biological_process +def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:rl] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0070092 +name: regulation of glucagon secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:mah] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0070091 ! glucagon secretion + +[Term] +id: GO:0070093 +name: negative regulation of glucagon secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:mah] +synonym: "down regulation of glucagon secretion" EXACT [] +synonym: "down-regulation of glucagon secretion" EXACT [] +synonym: "downregulation of glucagon secretion" EXACT [] +synonym: "inhibition of glucagon secretion" NARROW [] +is_a: GO:0002792 ! negative regulation of peptide secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0070092 ! regulation of glucagon secretion +relationship: negatively_regulates GO:0070091 ! glucagon secretion + +[Term] +id: GO:0070094 +name: positive regulation of glucagon secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:mah] +synonym: "activation of glucagon secretion" NARROW [] +synonym: "stimulation of glucagon secretion" NARROW [] +synonym: "up regulation of glucagon secretion" EXACT [] +synonym: "up-regulation of glucagon secretion" EXACT [] +synonym: "upregulation of glucagon secretion" EXACT [] +is_a: GO:0002793 ! positive regulation of peptide secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0070092 ! regulation of glucagon secretion +relationship: positively_regulates GO:0070091 ! glucagon secretion + +[Term] +id: GO:0070095 +name: fructose-6-phosphate binding +namespace: molecular_function +def: "Interacting selectively with fructose 6-phosphate." [GOC:mah] +synonym: "D-fructose 6-phosphate binding" NARROW [] +synonym: "fructose 6-phosphate binding" EXACT [] +is_a: GO:0070061 ! fructose binding + +[Term] +id: GO:0070096 +name: mitochondrial outer membrane translocase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:vk] +is_a: GO:0043623 ! cellular protein complex assembly +relationship: part_of GO:0007008 ! outer mitochondrial membrane organization + +[Term] +id: GO:0070097 +name: delta-catenin binding +namespace: molecular_function +def: "Interacting selectively with the delta subunit of the catenin complex." [GOC:rph] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0070098 +name: chemokine-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070099 +name: regulation of chemokine-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0070100 +name: negative regulation of chemokine-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine mediated signaling pathway +is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway +relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0070101 +name: positive regulation of chemokine-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine mediated signaling pathway +is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway +relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0070102 +name: interleukin-6-mediated signaling pathway +namespace: biological_process +def: "A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:add, GOC:mah] +synonym: "IL-6-mediated signaling pathway" RELATED [] +synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070103 +name: regulation of interleukin-6-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor." [GOC:mah] +synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] +synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway + +[Term] +id: GO:0070104 +name: negative regulation of interleukin-6-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:mah] +synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine mediated signaling pathway +is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway +relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway + +[Term] +id: GO:0070105 +name: positive regulation of interleukin-6-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:mah] +synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine mediated signaling pathway +is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway +relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway + +[Term] +id: GO:0070106 +name: interleukin-27-mediated signaling pathway +namespace: biological_process +def: "A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:add, GOC:mah] +synonym: "IL-27-mediated signaling pathway" RELATED [] +synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070107 +name: regulation of interleukin-27-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor." [GOC:mah] +synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "regulation of IL27RA/IL6ST signaling pathway" RELATED [GOC:add] +synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine mediated signaling pathway +relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway + +[Term] +id: GO:0070108 +name: negative regulation of interleukin-27-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:mah] +synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine mediated signaling pathway +is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway +relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway + +[Term] +id: GO:0070109 +name: positive regulation of interleukin-27-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:mah] +synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine mediated signaling pathway +is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway +relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway + +[Term] +id: GO:0070110 +name: ciliary neurotrophic factor receptor complex +namespace: cellular_component +def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:mah, GOC:rl, PMID:12707266] +is_a: GO:0043235 ! receptor complex +is_a: GO:0044459 ! plasma membrane part +relationship: part_of GO:0005887 ! integral to plasma membrane + +[Term] +id: GO:0070111 +name: organellar chromatophore +namespace: cellular_component +def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055] +synonym: "Paulinella-type chromatophore" EXACT [] +is_a: GO:0043660 ! bacteroid-containing symbiosome + +[Term] +id: GO:0070112 +name: organellar chromatophore membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah] +subset: gosubset_prok +synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0070111 ! organellar chromatophore + +[Term] +id: GO:0070113 +name: organellar chromatophore inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah] +is_a: GO:0070112 ! organellar chromatophore membrane + +[Term] +id: GO:0070114 +name: organellar chromatophore outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah] +is_a: GO:0043661 ! peribacteroid membrane +is_a: GO:0070112 ! organellar chromatophore membrane + +[Term] +id: GO:0070115 +name: organellar chromatophore intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah] +subset: gosubset_prok +synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah] +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0070111 ! organellar chromatophore + +[Term] +id: GO:0070116 +name: organellar chromatophore thylakoid +namespace: cellular_component +def: "A thylakoid located in an organellar chromatophore." [GOC:mah] +subset: gosubset_prok +synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah] +is_a: GO:0009579 ! thylakoid +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0070111 ! organellar chromatophore + +[Term] +id: GO:0070117 +name: organellar chromatophore thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah] +synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah] +is_a: GO:0031977 ! thylakoid lumen +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0070116 ! organellar chromatophore thylakoid + +[Term] +id: GO:0070118 +name: organellar chromatophore thylakoid membrane +namespace: cellular_component +def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah] +is_a: GO:0042651 ! thylakoid membrane +is_a: GO:0044433 ! cytoplasmic vesicle part +relationship: part_of GO:0070116 ! organellar chromatophore thylakoid + +[Term] +id: GO:0070119 +name: ciliary neurotrophic factor binding +namespace: molecular_function +def: "Interacting selectively with the cytokine ciliary neurotrophic factor." [GOC:mah] +synonym: "CNTF binding" EXACT [GOC:mah] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0070120 +name: ciliary neurotrophic factor-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of ciliary neurotrophic factor binding to a cell surface receptor." [GOC:mah] +synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah] +synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070121 +name: Kupffer's vesicle development +namespace: biological_process +def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh] +synonym: "KV development" EXACT [GOC:dgh] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0070122 +name: isopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, http:128.240.24.212/cgi-bin/omd?isopeptide+bond] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070123 +name: transforming growth factor beta receptor activity, type III +namespace: molecular_function +def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:mah, PMID:9759503] +synonym: "betaglycan" NARROW [] +synonym: "endoglin" NARROW [] +synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] +synonym: "type III TGF-beta receptor activity" EXACT [] +synonym: "type III TGFbeta receptor activity" EXACT [] +synonym: "type III transforming growth factor beta receptor activity" EXACT [] +is_a: GO:0005024 ! transforming growth factor beta receptor activity + +[Term] +id: GO:0070124 +name: mitochondrial translational initiation +namespace: biological_process +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah] +synonym: "mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0006413 ! translational initiation +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070125 +name: mitochondrial translational elongation +namespace: biological_process +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] +synonym: "mitochondrial translation elongation" EXACT [GOC:mah] +is_a: GO:0006414 ! translational elongation +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070126 +name: mitochondrial translational termination +namespace: biological_process +def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http:mitogenome.org/index.php/Genetic_Code_of_mitochondria] +synonym: "mitochondrial translation termination" EXACT [GOC:mah] +is_a: GO:0006415 ! translational termination +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070127 +name: tRNA aminoacylation for mitochondrial protein translation +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070128 +name: conversion of mitochondrial met-tRNAf to fmet-tRNA +namespace: biological_process +def: "The process whereby methionine carried by an initiator methionine tRNA ina mitochondrion is N-formylated." [GOC:mah] +synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" EXACT [] +is_a: GO:0001718 ! conversion of met-tRNAf to fmet-tRNA +relationship: part_of GO:0006413 ! translational initiation + +[Term] +id: GO:0070129 +name: regulation of mitochondrial translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] +synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah] +synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] +synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah] +synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah] +is_a: GO:0006417 ! regulation of translation +relationship: regulates GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070130 +name: negative regulation of mitochondrial translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] +synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0070129 ! regulation of mitochondrial translation +relationship: negatively_regulates GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070131 +name: positive regulation of mitochondrial translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] +synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0070129 ! regulation of mitochondrial translation +relationship: positively_regulates GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070132 +name: regulation of mitochondrial translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] +synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0006446 ! regulation of translational initiation +relationship: regulates GO:0070124 ! mitochondrial translational initiation + +[Term] +id: GO:0070133 +name: negative regulation of mitochondrial translational initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] +synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0045947 ! negative regulation of translational initiation +is_a: GO:0070132 ! regulation of mitochondrial translational initiation +relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation + +[Term] +id: GO:0070134 +name: positive regulation of mitochondrial translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] +synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0045948 ! positive regulation of translational initiation +is_a: GO:0070132 ! regulation of mitochondrial translational initiation +relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation + +[Term] +id: GO:0070135 +name: beta-1,2-oligomannoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] +synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process + +[Term] +id: GO:0070136 +name: beta-1,2-oligomannoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] +synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah] +synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah] +synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah] +synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah] +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process +is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process + +[Term] +id: GO:0070137 +name: small conjugating protein-specific endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds between analpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah] +is_a: GO:0004197 ! cysteine-type endopeptidase activity +is_a: GO:0019783 ! small conjugating protein-specific protease activity + +[Term] +id: GO:0070138 +name: small conjugating protein-specific isopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated." [GOC:mah] +is_a: GO:0019783 ! small conjugating protein-specific protease activity +is_a: GO:0070122 ! isopeptidase activity + +[Term] +id: GO:0070139 +name: SUMO-specific endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds between analpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah] +is_a: GO:0016929 ! SUMO-specific protease activity +is_a: GO:0070137 ! small conjugating protein-specific endopeptidase activity + +[Term] +id: GO:0070140 +name: SUMO-specific isopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah] +is_a: GO:0016929 ! SUMO-specific protease activity +is_a: GO:0070138 ! small conjugating protein-specific isopeptidase activity + +[Term] +id: GO:0070141 +name: response to UV-A +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 400 to 500 nm." [GOC:mah] +synonym: "response to UV-A light stimulus" EXACT [] +synonym: "response to UV-A radiation stimulus" EXACT [] +synonym: "response to UVA light stimulus" EXACT [] +synonym: "response to UVA radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0070142 +name: synaptic vesicle budding +namespace: biological_process +def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah] +is_a: GO:0006900 ! membrane budding +relationship: part_of GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:0070143 +name: mitochondrial alanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006419 ! alanyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070144 +name: mitochondrial arginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006420 ! arginyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070145 +name: mitochondrial asparaginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070146 +name: mitochondrial aspartyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006422 ! aspartyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070147 +name: mitochondrial cysteinyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070148 +name: mitochondrial glutaminyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070149 +name: mitochondrial glutamyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006424 ! glutamyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070150 +name: mitochondrial glycyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006426 ! glycyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070151 +name: mitochondrial histidyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006427 ! histidyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070152 +name: mitochondrial isoleucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070153 +name: mitochondrial leucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006429 ! leucyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070154 +name: mitochondrial lysyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006430 ! lysyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070155 +name: mitochondrial methionyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006431 ! methionyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070156 +name: mitochondrial phenylalanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070157 +name: mitochondrial prolyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006433 ! prolyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070158 +name: mitochondrial seryl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006434 ! seryl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070159 +name: mitochondrial threonyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006435 ! threonyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070160 +name: occluding junction +namespace: cellular_component +def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] +synonym: "occluding cell junction" EXACT [GOC:mah] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0070161 +name: anchoring junction +namespace: cellular_component +def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] +synonym: "anchoring cell junction" EXACT [GOC:mah] +is_a: GO:0030054 ! cell junction + +[Term] +id: GO:0075000 +name: response to host osmotic environment +namespace: biological_process +def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response of symbiont to host osmotic environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075001 +name: adhesion of symbiont infection structure to host +namespace: biological_process +def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. +synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT [] +synonym: "attachment of symbiont infection structure to host" EXACT [] +is_a: GO:0044406 ! adhesion to host + +[Term] +id: GO:0075002 +name: adhesion of symbiont germination tube to host +namespace: biological_process +def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075003 +name: adhesion of symbiont appressorium to host +namespace: biological_process +def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075004 +name: adhesion of symbiont spore to host +namespace: biological_process +def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT [] +is_a: GO:0044406 ! adhesion to host + +[Term] +id: GO:0075005 +name: spore germination on or near host +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0009847 ! spore germination +is_a: GO:0044408 ! growth or development of symbiont on or near host +is_a: GO:0051701 ! interaction with host + +[Term] +id: GO:0075006 +name: modulation of spore germination on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +relationship: regulates GO:0075005 ! spore germination on or near host + +[Term] +id: GO:0075007 +name: positive regulation of spore germination on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075006 ! modulation of spore germination on or near host +is_a: GO:0075337 ! positive regulation of growth or development of symbiont on or near host surface +relationship: positively_regulates GO:0075005 ! spore germination on or near host + +[Term] +id: GO:0075008 +name: negative regulation of spore germination on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075006 ! modulation of spore germination on or near host +is_a: GO:0075309 ! negative regulation of growth or development of symbiont on or near host surface +relationship: negatively_regulates GO:0075005 ! spore germination on or near host + +[Term] +id: GO:0075009 +name: germ tube formation on or near host +namespace: biological_process +def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044408 ! growth or development of symbiont on or near host +relationship: part_of GO:0075005 ! spore germination on or near host + +[Term] +id: GO:0075010 +name: modulation of germ tube formation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075006 ! modulation of spore germination on or near host +relationship: regulates GO:0075009 ! germ tube formation on or near host + +[Term] +id: GO:0075011 +name: positive regulation of germ tube formation on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075007 ! positive regulation of spore germination on or near host +is_a: GO:0075010 ! modulation of germ tube formation on or near host +relationship: positively_regulates GO:0075009 ! germ tube formation on or near host + +[Term] +id: GO:0075012 +name: negative regulation of germ tube formation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075008 ! negative regulation of spore germination on or near host +is_a: GO:0075010 ! modulation of germ tube formation on or near host +relationship: negatively_regulates GO:0075009 ! germ tube formation on or near host + +[Term] +id: GO:0075013 +name: growth or development of symbiont on or near host phyllosphere +namespace: biological_process +def: "The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075014 +name: growth or development of symbiont on or near host rhizosphere +namespace: biological_process +def: "The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075015 +name: formation of infection structure on or near host +namespace: biological_process +def: "The process by which a symbiont structure that serves to infect the host is formed on or near its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. +synonym: "formation by symbiont of infection structure on or near host" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +is_a: GO:0052108 ! growth or development of symbiont during interaction with host + +[Term] +id: GO:0075016 +name: appressorium formation on or near host +namespace: biological_process +def: "The process by which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "appressorium formation for entry into host, on or near host" EXACT [] +synonym: "formation of an appressorium by symbiont on or near host" EXACT [] +is_a: GO:0075013 ! growth or development of symbiont on or near host phyllosphere +is_a: GO:0075015 ! formation of infection structure on or near host + +[Term] +id: GO:0075017 +name: regulation of appressorium formation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +relationship: regulates GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075018 +name: positive regulation of appressorium formation on or near host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075017 ! regulation of appressorium formation on or near host +is_a: GO:0075337 ! positive regulation of growth or development of symbiont on or near host surface +relationship: positively_regulates GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075019 +name: negative regulation of appressorium formation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075017 ! regulation of appressorium formation on or near host +is_a: GO:0075309 ! negative regulation of growth or development of symbiont on or near host surface +relationship: negatively_regulates GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075020 +name: calcium or calmodulin-mediated activation of appressorium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT [] +synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT [] +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host + +[Term] +id: GO:0075021 +name: cAMP-mediated activation of appressorium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "cyclic AMP mediated activation of appressorium formation" EXACT [] +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host + +[Term] +id: GO:0075022 +name: ethylene-mediated activation of appressorium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host + +[Term] +id: GO:0075023 +name: MAPK-mediated regulation of appressorium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT [] +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host + +[Term] +id: GO:0075024 +name: phospholipase C-mediated activation of appressorium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host + +[Term] +id: GO:0075025 +name: initiation of appressorium on or near host +namespace: biological_process +def: "The process whereby a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "appressorium initiation on or near host" EXACT [] +synonym: "initiation of appressorium by symbiont on or near host" EXACT [] +synonym: "initiation of symbiont appressorium on or near host" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075026 +name: regulation of appressorium initiation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "regulation of initiation of appressorium on or near host" EXACT [] +is_a: GO:0075017 ! regulation of appressorium formation on or near host +relationship: regulates GO:0075025 ! initiation of appressorium on or near host + +[Term] +id: GO:0075027 +name: positive regulation of appressorium initiation on or near host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation of initiation of appressorium on or near host" EXACT [] +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host +is_a: GO:0075026 ! regulation of appressorium initiation on or near host +relationship: positively_regulates GO:0075025 ! initiation of appressorium on or near host + +[Term] +id: GO:0075028 +name: negative regulation of appressorium initiation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent symbiont appressorium initiation near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "negative regulation of initiation of appressorium on or near host" EXACT [] +is_a: GO:0075019 ! negative regulation of appressorium formation on or near host +is_a: GO:0075026 ! regulation of appressorium initiation on or near host +relationship: negatively_regulates GO:0075025 ! initiation of appressorium on or near host + +[Term] +id: GO:0075029 +name: formation of symbiont germ tube hook structure on or near host +namespace: biological_process +def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +synonym: "symbiont germ tube hook structure formation on or near host" EXACT [] +is_a: GO:0075015 ! formation of infection structure on or near host +relationship: part_of GO:0075025 ! initiation of appressorium on or near host + +[Term] +id: GO:0075030 +name: modulation of symbiont germ tube hook structure formation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] +is_a: GO:0075026 ! regulation of appressorium initiation on or near host +relationship: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host + +[Term] +id: GO:0075031 +name: positive regulation of symbiont germ tube hook structure formation on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] +synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +is_a: GO:0075027 ! positive regulation of appressorium initiation on or near host +is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host +relationship: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host + +[Term] +id: GO:0075032 +name: negative regulation of symbiont germ tube hook structure formation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] +synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +is_a: GO:0075028 ! negative regulation of appressorium initiation on or near host +is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host +relationship: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host + +[Term] +id: GO:0075033 +name: septum formation during appressorium formation on or near host +namespace: biological_process +def: "The process by which a symbiont partition is formed to separate the appressorium from the germination tube, occurring on or near the exterior of its host organism during appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044408 ! growth or development of symbiont on or near host +relationship: part_of GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075034 +name: nuclear division during appressorium formation on or near host +namespace: biological_process +def: "The process by which nuclear division occurs within a symbiont spore during appressorium formation on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0000280 ! nuclear division +relationship: part_of GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075035 +name: maturation of appressorium on or near host +namespace: biological_process +def: "The process whereby specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "appressorium maturation on or near host" EXACT [] +synonym: "maturation of symbiont appressorium on or near host" EXACT [] +is_a: GO:0052108 ! growth or development of symbiont during interaction with host +relationship: part_of GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075036 +name: regulation of appressorium maturation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "regulation of maturation of appressorium on or near host" EXACT [] +is_a: GO:0075017 ! regulation of appressorium formation on or near host +relationship: regulates GO:0075035 ! maturation of appressorium on or near host + +[Term] +id: GO:0075037 +name: positive regulation of appressorium maturation on or near host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation maturation of appressorium on or near host" EXACT [] +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host +is_a: GO:0075036 ! regulation of appressorium maturation on or near host +relationship: positively_regulates GO:0075035 ! maturation of appressorium on or near host + +[Term] +id: GO:0075038 +name: negative regulation of appressorium maturation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent symbiont appressorium maturation in, near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "negative regulation of maturation of appressorium on or near host" EXACT [] +is_a: GO:0075019 ! negative regulation of appressorium formation on or near host +is_a: GO:0075036 ! regulation of appressorium maturation on or near host +relationship: negatively_regulates GO:0075035 ! maturation of appressorium on or near host + +[Term] +id: GO:0075039 +name: establishment of turgor in appressorium +namespace: biological_process +def: "The process whereby hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT [] +synonym: "formation of turgor in appressorium" EXACT [] +synonym: "generation of turgor in appressorium" EXACT [] +is_a: GO:0052108 ! growth or development of symbiont during interaction with host +relationship: part_of GO:0075035 ! maturation of appressorium on or near host + +[Term] +id: GO:0075040 +name: regulation of establishment of turgor in appressorium +namespace: biological_process +def: "Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "regulation of turgor formation in appressorium" RELATED [] +is_a: GO:0075036 ! regulation of appressorium maturation on or near host +relationship: regulates GO:0075039 ! establishment of turgor in appressorium + +[Term] +id: GO:0075041 +name: positive regulation of establishment of turgor in appressorium +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075018 ! positive regulation of appressorium formation on or near host +is_a: GO:0075040 ! regulation of establishment of turgor in appressorium +relationship: positively_regulates GO:0075039 ! establishment of turgor in appressorium + +[Term] +id: GO:0075042 +name: negative regulation of establishment of turgor in appressorium +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075038 ! negative regulation of appressorium maturation on or near host +is_a: GO:0075040 ! regulation of establishment of turgor in appressorium +relationship: negatively_regulates GO:0075039 ! establishment of turgor in appressorium + +[Term] +id: GO:0075043 +name: maintenance of turgor in appressorium by melanization +namespace: biological_process +def: "The process whereby melanin is produced in the appressorium of the symbiont on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "melanization of appressorium to maintain turgor pressure" EXACT [] +is_a: GO:0042438 ! melanin biosynthetic process +is_a: GO:0075040 ! regulation of establishment of turgor in appressorium + +[Term] +id: GO:0075044 +name: autophagy of host cells during interaction with symbiont +namespace: biological_process +def: "The process by which the host cells digest parts of their own cytoplasm during interaction with its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should be used to annotate gene products of host. +is_a: GO:0075071 ! autophagy during symbiotic interaction + +[Term] +id: GO:0075045 +name: regulation of formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0033665 ! regulation of growth or development of symbiont within host +relationship: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host + +[Term] +id: GO:0075046 +name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0033666 ! positive regulation of growth or development of symbiont within host +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host +relationship: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host + +[Term] +id: GO:0075047 +name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0033667 ! negative regulation of growth or development of symbiont within host +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host +relationship: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host + +[Term] +id: GO:0075048 +name: cell wall strengthening in symbiont during entry into host +namespace: biological_process +def: "A process whereby the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "cell wall thickening in symbiont during entry into host" EXACT [] +synonym: "symbiont cell wall strengthening during entry into host" EXACT [] +is_a: GO:0052386 ! cell wall thickening +relationship: part_of GO:0044409 ! entry into host + +[Term] +id: GO:0075049 +name: modulation of symbiont cell wall strengthening during entry into host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0044419 ! interspecies interaction between organisms +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0052372 ! modulation by symbiont of entry into host +relationship: regulates GO:0075048 ! cell wall strengthening in symbiont during entry into host + +[Term] +id: GO:0075050 +name: positive regulation of symbiont cell wall strengthening during entry into host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0075049 ! modulation of symbiont cell wall strengthening during entry into host +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +relationship: positively_regulates GO:0075048 ! cell wall strengthening in symbiont during entry into host + +[Term] +id: GO:0075051 +name: negative regulation of symbiont cell wall strengthening during entry into host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0052374 ! negative regulation by symbiont of entry into host +is_a: GO:0075049 ! modulation of symbiont cell wall strengthening during entry into host +relationship: negatively_regulates GO:0075048 ! cell wall strengthening in symbiont during entry into host + +[Term] +id: GO:0075052 +name: entry into host via a specialized structure +namespace: biological_process +def: "Penetration via a specialized structure of symbiont into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "entry into host via a specialized structure during symbiotic interaction" EXACT [] +is_a: GO:0044409 ! entry into host + +[Term] +id: GO:0075053 +name: formation of symbiont penetration peg for entry into host +namespace: biological_process +def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "symbiont penetration peg formation for entry into host" EXACT [] +is_a: GO:0075015 ! formation of infection structure on or near host +relationship: part_of GO:0075052 ! entry into host via a specialized structure + +[Term] +id: GO:0075054 +name: modulation of symbiont penetration peg formation for entry into host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: regulates GO:0075053 ! formation of symbiont penetration peg for entry into host + +[Term] +id: GO:0075055 +name: positive regulation of symbiont penetration peg formation for entry into host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host + +[Term] +id: GO:0075056 +name: negative regulation of symbiont penetration peg formation for entry into host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0052374 ! negative regulation by symbiont of entry into host +is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host + +[Term] +id: GO:0075057 +name: initiation of symbiont penetration peg +namespace: biological_process +def: "The process whereby a relatively unspecialized cell of the symbiont starts to acquire the characteristics of a mature penetration peg to penetrate into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "symbiont penetration peg initiation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation +relationship: part_of GO:0075053 ! formation of symbiont penetration peg for entry into host + +[Term] +id: GO:0075058 +name: modulation of symbiont penetration peg initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of penetration peg initiation, the process whereby a relatively unspecialized cell start to acquire the characteristics of a mature penetration peg when the symbiont penetrates its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host +relationship: regulates GO:0075057 ! initiation of symbiont penetration peg + +[Term] +id: GO:0075059 +name: positive regulation of symbiont penetration peg initiation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg initiation, the process whereby a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075055 ! positive regulation of symbiont penetration peg formation for entry into host +is_a: GO:0075058 ! modulation of symbiont penetration peg initiation +relationship: positively_regulates GO:0075057 ! initiation of symbiont penetration peg + +[Term] +id: GO:0075060 +name: negative regulation of symbiont penetration peg initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont penetration peg initiation, the process whereby a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075056 ! negative regulation of symbiont penetration peg formation for entry into host +is_a: GO:0075058 ! modulation of symbiont penetration peg initiation +relationship: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg + +[Term] +id: GO:0075061 +name: formation of symbiont invasive hypha within host +namespace: biological_process +def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of invasive growth within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT [] +synonym: "symbiont invasive hypha formation within host" EXACT [] +is_a: GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0075062 +name: regulation of symbiont invasive hypha formation within host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0033665 ! regulation of growth or development of symbiont within host +relationship: regulates GO:0075061 ! formation of symbiont invasive hypha within host + +[Term] +id: GO:0075063 +name: positive regulation of symbiont invasive hypha formation within host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0033666 ! positive regulation of growth or development of symbiont within host +is_a: GO:0075062 ! regulation of symbiont invasive hypha formation within host +relationship: positively_regulates GO:0075061 ! formation of symbiont invasive hypha within host + +[Term] +id: GO:0075064 +name: negative regulation of symbiont invasive hypha formation within host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0033667 ! negative regulation of growth or development of symbiont within host +is_a: GO:0075062 ! regulation of symbiont invasive hypha formation within host +relationship: negatively_regulates GO:0075061 ! formation of symbiont invasive hypha within host + +[Term] +id: GO:0075065 +name: growth or development of symbiont in host cell +namespace: biological_process +def: "The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0075066 +name: growth or development of symbiont in host organelle +namespace: biological_process +def: "The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075065 ! growth or development of symbiont in host cell + +[Term] +id: GO:0075067 +name: growth or development of symbiont in host intercellular space +namespace: biological_process +def: "The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0075068 +name: growth or development of symbiont in host vascular tissue +namespace: biological_process +def: "The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0044412 ! growth or development of symbiont within host + +[Term] +id: GO:0075069 +name: adhesion of symbiont infection cushion to host +namespace: biological_process +def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075070 +name: adhesion of symbiont hyphopodium to host +namespace: biological_process +def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075071 +name: autophagy during symbiotic interaction +namespace: biological_process +def: "The process by which cells digest parts of their own cytoplasm during a symbiotic interaction; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should be used to annotate gene products of the organism involved in this process. +is_a: GO:0006914 ! autophagy +relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism + +[Term] +id: GO:0075072 +name: autophagy of symbiont cells during interaction with host +namespace: biological_process +def: "The process by which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should be used to annotate gene products of symbiont. +is_a: GO:0075071 ! autophagy during symbiotic interaction +relationship: part_of GO:0051701 ! interaction with host + +[Term] +id: GO:0075073 +name: autophagy of symbiont cells on or near host surface +namespace: biological_process +def: "The process by which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should be used to annotate gene products of symbiont. +is_a: GO:0075072 ! autophagy of symbiont cells during interaction with host + +[Term] +id: GO:0075074 +name: spore autophagy during appressorium formation on or near host +namespace: biological_process +def: "The process by which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "autophagy of spores during appressorium formation on or near host" EXACT [] +is_a: GO:0075073 ! autophagy of symbiont cells on or near host surface +relationship: part_of GO:0075016 ! appressorium formation on or near host + +[Term] +id: GO:0075075 +name: modulation by host of symbiont adenylate cyclase activity +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase activity ; GO:0075106". +is_a: GO:0045761 ! regulation of adenylate cyclase activity +is_a: GO:0052422 ! modification by host of symbiont catalytic activity + +[Term] +id: GO:0075076 +name: positive regulation by host of symbiont adenylate cyclase activity +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase activity ; GO:0075107". +is_a: GO:0043947 ! positive regulation by host of symbiont enzyme activity +is_a: GO:0045762 ! positive regulation of adenylate cyclase activity +is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity + +[Term] +id: GO:0075077 +name: negative regulation by host of symbiont adenylate cyclase activity +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host adenylate cyclase activity ; GO:0075108". +is_a: GO:0007194 ! negative regulation of adenylate cyclase activity +is_a: GO:0052403 ! negative regulation by host of symbiont enzyme activity +is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity + +[Term] +id: GO:0075078 +name: modulation by host of symbiont receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host receptor-mediated signal transduction ; GO:0075109". +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway + +[Term] +id: GO:0075079 +name: positive regulation by host of symbiont receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host receptor-mediated signal transduction ; GO:0075110". +is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction + +[Term] +id: GO:0075080 +name: negative regulation by host of symbiont receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host receptor-mediated signal transduction ; GO:0075111". +is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction + +[Term] +id: GO:0075081 +name: modulation by host of symbiont transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075112". +is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction + +[Term] +id: GO:0075082 +name: positive regulation by host of symbiont transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075113". +is_a: GO:0075079 ! positive regulation by host of symbiont receptor-mediated signal transduction +is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075083 +name: negative regulation by host of symbiont transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075114". +is_a: GO:0075080 ! negative regulation by host of symbiont receptor-mediated signal transduction +is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075084 +name: modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075115". +synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] +is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction +is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction + +[Term] +id: GO:0075085 +name: positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075116". +synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] +synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT [] +synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] +is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction +is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +is_a: GO:0075206 ! positive regulation by host of symbiont cAMP-mediated signal transduction + +[Term] +id: GO:0075086 +name: negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075117". +synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] +is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction +is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +is_a: GO:0075207 ! negative regulation by host of symbiont cAMP-mediated signal transduction + +[Term] +id: GO:0075087 +name: modulation by host of symbiont G-protein coupled receptor protein signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075118". +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075088 +name: positive regulation by host of symbiont G-protein coupled receptor protein signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075119". +is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction +is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075089 +name: negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075120". +is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction +is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075090 +name: modulation by host of symbiont signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075121". +is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075091 +name: positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075122". +is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction +is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit + +[Term] +id: GO:0075092 +name: negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075123". +is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit + +[Term] +id: GO:0075093 +name: modulation by host of symbiont signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075124". +is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075094 +name: positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075125". +is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction +is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit + +[Term] +id: GO:0075095 +name: negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075126". +is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit + +[Term] +id: GO:0075096 +name: modulation by host of symbiont signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075127". +is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075097 +name: positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075128". +is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction +is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit + +[Term] +id: GO:0075098 +name: negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075129". +is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit + +[Term] +id: GO:0075099 +name: modulation by host of symbiont protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075130". +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway + +[Term] +id: GO:0075100 +name: positive regulation by host of symbiont protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075131". +is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction + +[Term] +id: GO:0075101 +name: negative regulation by host of symbiont protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075132". +is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction + +[Term] +id: GO:0075102 +name: negative regulation by host of symbiont MAP kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host MAP kinase-mediated signal transduction pathway ; GO:0052078". +is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway +is_a: GO:0075101 ! negative regulation by host of symbiont protein kinase-mediated signal transduction + +[Term] +id: GO:0075103 +name: modulation by host of symbiont calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075133". +synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway + +[Term] +id: GO:0075104 +name: positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075134". +synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway +is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction + +[Term] +id: GO:0075105 +name: negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075135". +synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway +is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction + +[Term] +id: GO:0075106 +name: modulation by symbiont of host adenylate cyclase activity +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont adenylate cyclase activity ; GO:0075075". +synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] +synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT [] +synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT [] +synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT [] +synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] +synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] +synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] +synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED [] +is_a: GO:0045761 ! regulation of adenylate cyclase activity +is_a: GO:0052148 ! modification by symbiont of host catalytic activity + +[Term] +id: GO:0075107 +name: positive regulation by symbiont of host adenylate cyclase activity +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont adenylate cyclase activity ; GO:0075076". +synonym: "Positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] +synonym: "Positive regulation by symbiont of host adenyl cyclase activity" EXACT [] +synonym: "Positive regulation by symbiont of host adenylyl cyclase activity" EXACT [] +synonym: "Positive regulation by symbiont of host adenylylcyclase activity" EXACT [] +synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] +synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] +synonym: "Positive regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] +synonym: "Positive regulation by symbiont of host cAMP generating peptide activity" RELATED [] +is_a: GO:0043948 ! positive regulation by symbiont of host enzyme activity +is_a: GO:0045762 ! positive regulation of adenylate cyclase activity +is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity + +[Term] +id: GO:0075108 +name: negative regulation by symbiont of host adenylate cyclase activity +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont adenylate cyclase activity ; GO:0075077". +synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] +synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT [] +synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT [] +synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT [] +synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] +synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] +synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] +synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED [] +is_a: GO:0007194 ! negative regulation of adenylate cyclase activity +is_a: GO:0052053 ! negative regulation by symbiont of host enzyme activity +is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity + +[Term] +id: GO:0075109 +name: modulation by symbiont of host receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078". +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075110 +name: positive regulation by symbiont of host receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079". +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0075111 +name: negative regulation by symbiont of host receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080". +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0075112 +name: modulation by symbiont of host transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081". +is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0075113 +name: positive regulation by symbiont of host transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082". +is_a: GO:0075110 ! positive regulation by symbiont of host receptor-mediated signal transduction +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075114 +name: negative regulation by symbiont of host transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083". +is_a: GO:0075111 ! negative regulation by symbiont of host receptor-mediated signal transduction +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075115 +name: modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075084". +synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075116 +name: positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075085". +synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] +synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction +is_a: GO:0075209 ! positive regulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075117 +name: negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075086". +synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] +is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction +is_a: GO:0075210 ! negative regulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075118 +name: modulation by symbiont of host G-protein coupled receptor protein signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075087". +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075119 +name: positive regulation by symbiont of host G-protein coupled receptor protein signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075088". +is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075120 +name: negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075089". +is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075121 +name: modulation by symbiont of host signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075090". +is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075122 +name: positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075091". +is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction +is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit + +[Term] +id: GO:0075123 +name: negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075092". +is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit + +[Term] +id: GO:0075124 +name: modulation by symbiont of host signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075093". +is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075125 +name: positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075094". +is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction +is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit + +[Term] +id: GO:0075126 +name: negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075095". +is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit + +[Term] +id: GO:0075127 +name: modulation by symbiont of host signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075096". +is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction + +[Term] +id: GO:0075128 +name: positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075097". +is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction +is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit + +[Term] +id: GO:0075129 +name: negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075098". +is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit + +[Term] +id: GO:0075130 +name: modulation by symbiont of host protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099". +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075131 +name: positive regulation by symbiont of host protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100". +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0075132 +name: negative regulation by symbiont of host protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101". +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0075133 +name: modulation by symbiont of host calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103". +synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075134 +name: positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104". +synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction + +[Term] +id: GO:0075135 +name: negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105". +synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction + +[Term] +id: GO:0075136 +name: response to host +namespace: biological_process +def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +subset: gosubset_prok +synonym: "response of symbiont to host" RELATED [] +is_a: GO:0051701 ! interaction with host +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0075137 +name: response to host redox environment +namespace: biological_process +def: "A change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host redox environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075138 +name: response to host oxygen tension environment +namespace: biological_process +def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host oxygen tension environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075139 +name: response to host iron concentration +namespace: biological_process +def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host iron concentration" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075140 +name: response to host defense molecules +namespace: biological_process +def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting host defense molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host defense molecules" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075141 +name: maintenance of symbiont tolerance to host environment +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075142 +name: maintenance of symbiont tolerance to host oxygen tension environment +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against oxygen tension environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075138 ! response to host oxygen tension environment +is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment + +[Term] +id: GO:0075143 +name: maintenance of symbiont tolerance to host redox environment +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against redox environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075137 ! response to host redox environment +is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment + +[Term] +id: GO:0075144 +name: maintenance of symbiont tolerance to host iron concentration +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against iron concentration environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075139 ! response to host iron concentration +is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment + +[Term] +id: GO:0075145 +name: maintenance of symbiont tolerance to host defense molecules +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against defense molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075140 ! response to host defense molecules +is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment + +[Term] +id: GO:0075146 +name: maintenance of symbiont tolerance to host osmotic environment +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against osmotic environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075000 ! response to host osmotic environment +is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment + +[Term] +id: GO:0075147 +name: regulation of signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont signal transduction in response to host" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075148 +name: positive regulation of signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont signal transduction in response to host" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075149 +name: negative regulation of signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont signal transduction in response to host" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075150 +name: regulation of receptor-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075151 +name: positive regulation of receptor-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075148 ! positive regulation of signal transduction in response to host +is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host + +[Term] +id: GO:0075152 +name: negative regulation of receptor-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075149 ! negative regulation of signal transduction in response to host +is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host + +[Term] +id: GO:0075153 +name: regulation of transmembrane receptor-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host + +[Term] +id: GO:0075154 +name: positive regulation of transmembrane receptor-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075151 ! positive regulation of receptor-mediated signal transduction in response to host +is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host + +[Term] +id: GO:0075155 +name: negative regulation of transmembrane receptor-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075152 ! negative regulation of receptor-mediated signal transduction in response to host +is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host + +[Term] +id: GO:0075156 +name: regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] +is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host + +[Term] +id: GO:0075157 +name: positive regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] +is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host +is_a: GO:0075156 ! regulation of G-protein coupled receptor protein-mediated signal transduction in response to host + +[Term] +id: GO:0075158 +name: negative regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] +is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway +is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host +is_a: GO:0075156 ! regulation of G-protein coupled receptor protein-mediated signal transduction in response to host + +[Term] +id: GO:0075159 +name: regulation of G-protein alpha subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075156 ! regulation of G-protein coupled receptor protein-mediated signal transduction in response to host + +[Term] +id: GO:0075160 +name: positive regulation of G-protein alpha subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host + +[Term] +id: GO:0075161 +name: negative regulation of G-protein alpha subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host + +[Term] +id: GO:0075162 +name: regulation of G-protein beta subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075156 ! regulation of G-protein coupled receptor protein-mediated signal transduction in response to host + +[Term] +id: GO:0075163 +name: positive regulation of G-protein beta subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host + +[Term] +id: GO:0075164 +name: negative regulation of G-protein beta subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host + +[Term] +id: GO:0075165 +name: regulation of G-protein gamma subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075156 ! regulation of G-protein coupled receptor protein-mediated signal transduction in response to host + +[Term] +id: GO:0075166 +name: positive regulation of G-protein gamma subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host + +[Term] +id: GO:0075167 +name: negative regulation of G-protein gamma subunit-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein-mediated signal transduction in response to host +is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host + +[Term] +id: GO:0075168 +name: regulation of protein kinase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075169 +name: positive regulation of symbiont protein kinase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075148 ! positive regulation of signal transduction in response to host +is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host + +[Term] +id: GO:0075170 +name: negative regulation of protein kinase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075149 ! negative regulation of signal transduction in response to host +is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host + +[Term] +id: GO:0075171 +name: regulation of MAP kinase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host + +[Term] +id: GO:0075172 +name: positive regulation of MAP kinase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075169 ! positive regulation of symbiont protein kinase-mediated signal transduction in response to host +is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host + +[Term] +id: GO:0075173 +name: negative regulation of MAP kinase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075170 ! negative regulation of protein kinase-mediated signal transduction in response to host +is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host + +[Term] +id: GO:0075174 +name: regulation of cAMP-mediated signaling in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT [] +synonym: "regulation of cAMP-mediated signalling in response to host" EXACT [] +synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075175 +name: positive regulation of cAMP-mediated signaling in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT [] +synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT [] +synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075148 ! positive regulation of signal transduction in response to host +is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host + +[Term] +id: GO:0075176 +name: negative regulation of cAMP-mediated signaling in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT [] +synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT [] +synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] +is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling +is_a: GO:0075149 ! negative regulation of signal transduction in response to host +is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host + +[Term] +id: GO:0075177 +name: regulation of calcium or calmodulin-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] +synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075178 +name: positive regulation of calcium or calmodulin-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] +synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075148 ! positive regulation of signal transduction in response to host +is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host + +[Term] +id: GO:0075179 +name: negative regulation of calcium or calmodulin-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] +synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] +is_a: GO:0075149 ! negative regulation of signal transduction in response to host +is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host + +[Term] +id: GO:0075180 +name: regulation of transcription in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont transcription in response to host" EXACT [] +is_a: GO:0045449 ! regulation of transcription +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075181 +name: positive regulation of symbiont transcription in response to host +namespace: biological_process +def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0045941 ! positive regulation of transcription +is_a: GO:0075180 ! regulation of transcription in response to host + +[Term] +id: GO:0075182 +name: negative regulation of symbiont transcription in response to host +namespace: biological_process +def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0016481 ! negative regulation of transcription +is_a: GO:0075180 ! regulation of transcription in response to host + +[Term] +id: GO:0075183 +name: infection cushion formation on or near host +namespace: biological_process +def: "The process by which an organized mass of hyphae is formed on or near the host organism, and numerous infective hyphae develop from the hyphae mass. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075015 ! formation of infection structure on or near host + +[Term] +id: GO:0075184 +name: regulation of infection cushion formation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism +relationship: regulates GO:0075183 ! infection cushion formation on or near host + +[Term] +id: GO:0075185 +name: positive regulation of infection cushion formation on or near host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075184 ! regulation of infection cushion formation on or near host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0075183 ! infection cushion formation on or near host + +[Term] +id: GO:0075186 +name: negative regulation of infection cushion formation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075184 ! regulation of infection cushion formation on or near host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0075183 ! infection cushion formation on or near host + +[Term] +id: GO:0075187 +name: hyphopodium formation on or near host +namespace: biological_process +def: "The process by which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075015 ! formation of infection structure on or near host + +[Term] +id: GO:0075188 +name: regulation of hyphopodium formation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +relationship: regulates GO:0075187 ! hyphopodium formation on or near host + +[Term] +id: GO:0075189 +name: positive regulation of hyphopodium formation on or near host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075188 ! regulation of hyphopodium formation on or near host +is_a: GO:0075337 ! positive regulation of growth or development of symbiont on or near host surface +relationship: positively_regulates GO:0075187 ! hyphopodium formation on or near host + +[Term] +id: GO:0075190 +name: negative regulation of hyphopodium formation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075188 ! regulation of hyphopodium formation on or near host +is_a: GO:0075309 ! negative regulation of growth or development of symbiont on or near host surface +relationship: negatively_regulates GO:0075187 ! hyphopodium formation on or near host + +[Term] +id: GO:0075191 +name: autophagy of host cells on or near symbiont surface +namespace: biological_process +def: "The process by which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should be used to annotate gene products of host. +is_a: GO:0075044 ! autophagy of host cells during interaction with symbiont + +[Term] +id: GO:0075192 +name: haustorium mother cell formation on or near host +namespace: biological_process +def: "The process by which a symbiont cell is formed on or near its host organism, via separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075015 ! formation of infection structure on or near host + +[Term] +id: GO:0075193 +name: regulation of haustorium mother cell formation on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +relationship: regulates GO:0075192 ! haustorium mother cell formation on or near host + +[Term] +id: GO:0075194 +name: positive regulation of haustorium mother cell formation on or near host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host +is_a: GO:0075337 ! positive regulation of growth or development of symbiont on or near host surface +relationship: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host + +[Term] +id: GO:0075195 +name: negative regulation of haustorium mother cell formation on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host +is_a: GO:0075309 ! negative regulation of growth or development of symbiont on or near host surface +relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host + +[Term] +id: GO:0075196 +name: adhesion of symbiont haustorium mother cell to host +namespace: biological_process +def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: " adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075197 +name: formation of symbiont haustorium neck for entry into host +namespace: biological_process +def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "symbiont haustorium neck formation for entry into host" EXACT [] +is_a: GO:0075015 ! formation of infection structure on or near host +relationship: part_of GO:0075052 ! entry into host via a specialized structure + +[Term] +id: GO:0075198 +name: modulation of symbiont haustorium neck formation for entry into host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host + +[Term] +id: GO:0075199 +name: positive regulation of symbiont haustorium neck formation for entry into host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host + +[Term] +id: GO:0075200 +name: negative regulation of symbiont haustorium neck formation for entry into host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0052374 ! negative regulation by symbiont of entry into host +is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host + +[Term] +id: GO:0075201 +name: formation of symbiont penetration hypha for entry into host +namespace: biological_process +def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process by which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "symbiont penetration hypha formation for entry into host" EXACT [] +is_a: GO:0075015 ! formation of infection structure on or near host +relationship: part_of GO:0075052 ! entry into host via a specialized structure + +[Term] +id: GO:0075202 +name: modulation of symbiont penetration hypha formation for entry into host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host + +[Term] +id: GO:0075203 +name: positive regulation of symbiont penetration hypha formation for entry into host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host + +[Term] +id: GO:0075204 +name: negative regulation of symbiont penetration hypha formation for entry into host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0052374 ! negative regulation by symbiont of entry into host +is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host + +[Term] +id: GO:0075205 +name: modulation by host of symbiont cAMP-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host cAMP-mediated signal transduction ; GO:0075208". +synonym: "modulation by host of symbiont cAMP-mediated signal transduction" EXACT [] +synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED [] +synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT [] +synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT [] +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway + +[Term] +id: GO:0075206 +name: positive regulation by host of symbiont cAMP-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075209". +synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT [] +is_a: GO:0043950 ! positive regulation of cAMP-mediated signaling +is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway +is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction + +[Term] +id: GO:0075207 +name: negative regulation by host of symbiont cAMP-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075210". +synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT [] +is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling +is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway +is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction + +[Term] +id: GO:0075208 +name: modulation by symbiont of host cAMP-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205". +synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT [] +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075209 +name: positive regulation by symbiont of host cAMP-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206". +synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway +is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075210 +name: negative regulation by symbiont of host cAMP-mediated signal transduction +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207". +synonym: "negative regulation by symbiont of host cAMP-mediated signaling" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway +is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075211 +name: regulation of transmembrane receptor-mediated cAMP signaling in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] +synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] +synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT [] +is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host +is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host + +[Term] +id: GO:0075212 +name: positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED [] +is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host +is_a: GO:0075175 ! positive regulation of cAMP-mediated signaling in response to host +is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host + +[Term] +id: GO:0075213 +name: negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] +is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host +is_a: GO:0075176 ! negative regulation of cAMP-mediated signaling in response to host +is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host + +[Term] +id: GO:0075214 +name: spore encystment on host +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075215 +name: modulation of spore encystment on host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +relationship: regulates GO:0075214 ! spore encystment on host + +[Term] +id: GO:0075216 +name: positive regulation of spore encystment on host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075215 ! modulation of spore encystment on host +is_a: GO:0075337 ! positive regulation of growth or development of symbiont on or near host surface +relationship: positively_regulates GO:0075214 ! spore encystment on host + +[Term] +id: GO:0075217 +name: negative regulation of spore encystment on host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075215 ! modulation of spore encystment on host +is_a: GO:0075309 ! negative regulation of growth or development of symbiont on or near host surface +relationship: negatively_regulates GO:0075214 ! spore encystment on host + +[Term] +id: GO:0075218 +name: zoospore encystment on host +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075214 ! spore encystment on host + +[Term] +id: GO:0075219 +name: modulation of zoospore encystment on host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075215 ! modulation of spore encystment on host +relationship: regulates GO:0075218 ! zoospore encystment on host + +[Term] +id: GO:0075220 +name: positive regulation of zoospore encystment on host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075216 ! positive regulation of spore encystment on host +is_a: GO:0075219 ! modulation of zoospore encystment on host +relationship: positively_regulates GO:0075218 ! zoospore encystment on host + +[Term] +id: GO:0075221 +name: negative regulation of zoospore encystment on host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075217 ! negative regulation of spore encystment on host +is_a: GO:0075219 ! modulation of zoospore encystment on host +relationship: negatively_regulates GO:0075218 ! zoospore encystment on host + +[Term] +id: GO:0075222 +name: sporangium germination on or near host +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth occurring on or near its host organism. A sporangium is a structure producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [pamgo:go_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "direct germination on or near host" NARROW [] +synonym: "germination of symbiont sporangium on or near host" EXACT [] +synonym: "symbiont sporangium germination on or near host" EXACT [] +is_a: GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075223 +name: modulation of sporangium germination on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporangium germination. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +relationship: regulates GO:0075222 ! sporangium germination on or near host + +[Term] +id: GO:0075224 +name: positive regulation of sporangium germination on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075223 ! modulation of sporangium germination on or near host +is_a: GO:0075337 ! positive regulation of growth or development of symbiont on or near host surface +relationship: positively_regulates GO:0075222 ! sporangium germination on or near host + +[Term] +id: GO:0075225 +name: negative regulation of sporangium germination on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075223 ! modulation of sporangium germination on or near host +is_a: GO:0075309 ! negative regulation of growth or development of symbiont on or near host surface +relationship: negatively_regulates GO:0075222 ! sporangium germination on or near host + +[Term] +id: GO:0075226 +name: encysted zoospore germination on or near host +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in the symbiont encysted zoospore, which is on or near its host organism and germinates by developing a germ tube that may penetrate the host directly or indirectly through an appresorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075005 ! spore germination on or near host + +[Term] +id: GO:0075227 +name: modulation of encysted zoospore germination on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075006 ! modulation of spore germination on or near host +relationship: regulates GO:0075226 ! encysted zoospore germination on or near host + +[Term] +id: GO:0075228 +name: positive regulation of encysted zoospore germination on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075007 ! positive regulation of spore germination on or near host +is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host +relationship: positively_regulates GO:0075226 ! encysted zoospore germination on or near host + +[Term] +id: GO:0075229 +name: negative regulation of encysted zoospore germination on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0075008 ! negative regulation of spore germination on or near host +is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host +relationship: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host + +[Term] +id: GO:0075230 +name: spore movement on or near host +namespace: biological_process +def: "Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052127 ! movement on or near host + +[Term] +id: GO:0075231 +name: modulation of spore movement on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: regulates GO:0075230 ! spore movement on or near host + +[Term] +id: GO:0075232 +name: positive regulation of spore movement on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0043902 ! positive regulation of multi-organism process +is_a: GO:0075231 ! modulation of spore movement on or near host +relationship: positively_regulates GO:0075230 ! spore movement on or near host + +[Term] +id: GO:0075233 +name: negative regulation of spore movement on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0075231 ! modulation of spore movement on or near host +relationship: negatively_regulates GO:0075230 ! spore movement on or near host + +[Term] +id: GO:0075234 +name: zoospore movement on or near host +namespace: biological_process +def: "Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "zoospore motility on or near host" EXACT [] +is_a: GO:0075230 ! spore movement on or near host + +[Term] +id: GO:0075235 +name: modulation of zoospore movement on or near host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "regulation of zoospore motility on or near host" EXACT [] +is_a: GO:0075231 ! modulation of spore movement on or near host +relationship: regulates GO:0075234 ! zoospore movement on or near host + +[Term] +id: GO:0075236 +name: positive regulation of zoospore movement on or near host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075232 ! positive regulation of spore movement on or near host +is_a: GO:0075235 ! modulation of zoospore movement on or near host +relationship: positively_regulates GO:0075234 ! zoospore movement on or near host + +[Term] +id: GO:0075237 +name: negative regulation of zoospore movement on or near host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075233 ! negative regulation of spore movement on or near host +is_a: GO:0075235 ! modulation of zoospore movement on or near host +relationship: negatively_regulates GO:0075234 ! zoospore movement on or near host + +[Term] +id: GO:0075238 +name: maintenance of symbiont tolerance to host pH environment +namespace: biological_process +def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against pH environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment +is_a: GO:0075293 ! response to host pH environment + +[Term] +id: GO:0075239 +name: zoospore formation +namespace: biological_process +def: "The process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile uninucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075240 +name: regulation of zoospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile uninucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: regulates GO:0075239 ! zoospore formation + +[Term] +id: GO:0075241 +name: positive regulation of zoospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile uninucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0075240 ! regulation of zoospore formation +is_a: GO:0075287 ! positive regulation of sporangiospore formation +relationship: positively_regulates GO:0075239 ! zoospore formation + +[Term] +id: GO:0075242 +name: negative regulation of zoospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of zoospore formation, a process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile uninucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0075240 ! regulation of zoospore formation +is_a: GO:0075288 ! negative regulation of sporangiospore formation +relationship: negatively_regulates GO:0075239 ! zoospore formation + +[Term] +id: GO:0075243 +name: oospore formation +namespace: biological_process +def: "The process by which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075244 +name: regulation of oospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oospore formation, a process by which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075243 ! oospore formation + +[Term] +id: GO:0075245 +name: positive regulation of oospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process by which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075244 ! regulation of oospore formation +relationship: positively_regulates GO:0075243 ! oospore formation + +[Term] +id: GO:0075246 +name: negative regulation of oospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oospore formation, a process by which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075244 ! regulation of oospore formation +relationship: negatively_regulates GO:0075243 ! oospore formation + +[Term] +id: GO:0075247 +name: aeciospore formation +namespace: biological_process +def: "The process by which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075248 +name: regulation of aeciospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process by which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075247 ! aeciospore formation + +[Term] +id: GO:0075249 +name: positive regulation of aeciospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process by which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075248 ! regulation of aeciospore formation +relationship: positively_regulates GO:0075247 ! aeciospore formation + +[Term] +id: GO:0075250 +name: negative regulation of aeciospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aeciospore formation, a process by which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075248 ! regulation of aeciospore formation +relationship: negatively_regulates GO:0075247 ! aeciospore formation + +[Term] +id: GO:0075251 +name: ureidospore formation +namespace: biological_process +def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators] +synonym: "urediniospore formation" EXACT [] +synonym: "uredospore formation" EXACT [] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075252 +name: regulation of ureidospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ureidospore formation, a process by which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075251 ! ureidospore formation + +[Term] +id: GO:0075253 +name: positive regulation of ureidospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of ureidospore formation, a process by which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075252 ! regulation of ureidospore formation +relationship: positively_regulates GO:0075251 ! ureidospore formation + +[Term] +id: GO:0075254 +name: negative regulation of ureidospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ureidospore formation, a process by which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] +synonym: "teleutospore formation" EXACT [] +synonym: "teleutosporodesm formation" EXACT [] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075252 ! regulation of ureidospore formation +relationship: negatively_regulates GO:0075251 ! ureidospore formation + +[Term] +id: GO:0075255 +name: teliospore formation +namespace: biological_process +def: "The processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075256 +name: regulation of teliospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075255 ! teliospore formation + +[Term] +id: GO:0075257 +name: positive regulation of teliospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075256 ! regulation of teliospore formation +relationship: positively_regulates GO:0075255 ! teliospore formation + +[Term] +id: GO:0075258 +name: negative regulation of teliospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075256 ! regulation of teliospore formation +relationship: negatively_regulates GO:0075255 ! teliospore formation + +[Term] +id: GO:0075259 +name: spore-bearing organ development +namespace: biological_process +def: "The process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +synonym: "fruiting structure development" EXACT [] +is_a: GO:0048513 ! organ development + +[Term] +id: GO:0075260 +name: regulation of spore-bearing organ development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075261 +name: positive regulation of spore-bearing organ development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: positively_regulates GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075262 +name: negative regulation of spore-bearing organ development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore-bearing organ development, a process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: negatively_regulates GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075263 +name: oogonium development +namespace: biological_process +def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075264 +name: regulation of oogonium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075263 ! oogonium development + +[Term] +id: GO:0075265 +name: positive regulation of oogonium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075264 ! regulation of oogonium development +relationship: positively_regulates GO:0075263 ! oogonium development + +[Term] +id: GO:0075266 +name: negative regulation of oogonium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075264 ! regulation of oogonium development +relationship: negatively_regulates GO:0075263 ! oogonium development + +[Term] +id: GO:0075267 +name: aecium development +namespace: biological_process +def: "The process by which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075268 +name: regulation of aecium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aecium development, a process by which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075267 ! aecium development + +[Term] +id: GO:0075269 +name: positive regulation of aecium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process by which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075268 ! regulation of aecium development +relationship: positively_regulates GO:0075267 ! aecium development + +[Term] +id: GO:0075270 +name: negative regulation of aecium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aecium development, a process by which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075268 ! regulation of aecium development +relationship: negatively_regulates GO:0075267 ! aecium development + +[Term] +id: GO:0075271 +name: zygosporangium development +namespace: biological_process +def: "The process by which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075272 +name: regulation of zygosporangium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process by which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075271 ! zygosporangium development + +[Term] +id: GO:0075273 +name: positive regulation of zygosporangium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process by which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075272 ! regulation of zygosporangium development +relationship: positively_regulates GO:0075271 ! zygosporangium development + +[Term] +id: GO:0075274 +name: negative regulation of zygosporangium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of zygosporangium development, a process by which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075272 ! regulation of zygosporangium development +relationship: negatively_regulates GO:0075271 ! zygosporangium development + +[Term] +id: GO:0075275 +name: telium development +namespace: biological_process +def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075276 +name: regulation of telium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075275 ! telium development + +[Term] +id: GO:0075277 +name: positive regulation of telium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075276 ! regulation of telium development +relationship: positively_regulates GO:0075275 ! telium development + +[Term] +id: GO:0075278 +name: negative regulation of telium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075276 ! regulation of telium development +relationship: negatively_regulates GO:0075275 ! telium development + +[Term] +id: GO:0075279 +name: uredinium development +namespace: biological_process +def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +synonym: "development of uredium" EXACT [] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075280 +name: regulation of uredinium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075279 ! uredinium development + +[Term] +id: GO:0075281 +name: positive regulation of uredinium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075280 ! regulation of uredinium development +relationship: positively_regulates GO:0075279 ! uredinium development + +[Term] +id: GO:0075282 +name: negative regulation of uredinium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075280 ! regulation of uredinium development +relationship: negatively_regulates GO:0075279 ! uredinium development + +[Term] +id: GO:0075283 +name: sporulation resulting in formation of a multicellular or syncytial spore +namespace: biological_process +def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0043934 ! sporulation + +[Term] +id: GO:0075284 +name: asexual sporulation resulting in formation of a multicellular or syncytial spore +namespace: biological_process +def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators] +is_a: GO:0030436 ! asexual sporulation +is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore + +[Term] +id: GO:0075285 +name: sexual sporulation resulting in formation of a multicellular or syncytial spore +namespace: biological_process +def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] +is_a: GO:0034293 ! sexual sporulation +is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore + +[Term] +id: GO:0075286 +name: regulation of sporangiospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075287 +name: positive regulation of sporangiospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: positively_regulates GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075288 +name: negative regulation of sporangiospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporangiospore formation, a process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: negatively_regulates GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075289 +name: aplanospore formation +namespace: biological_process +def: "The process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075290 +name: regulation of aplanospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: regulates GO:0075289 ! aplanospore formation + +[Term] +id: GO:0075291 +name: positive regulation of aplanospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0075287 ! positive regulation of sporangiospore formation +is_a: GO:0075290 ! regulation of aplanospore formation +relationship: positively_regulates GO:0075289 ! aplanospore formation + +[Term] +id: GO:0075292 +name: negative regulation of aplanospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aplanospore formation, a process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0075288 ! negative regulation of sporangiospore formation +is_a: GO:0075290 ! regulation of aplanospore formation +relationship: negatively_regulates GO:0075289 ! aplanospore formation + +[Term] +id: GO:0075293 +name: response to host pH environment +namespace: biological_process +def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response of symbiont to host pH environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075294 +name: positive regulation by symbiont of entry into host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "activation by symbiont of entry into host" NARROW [] +synonym: "up regulation by symbiont of entry into host" EXACT [] +synonym: "up-regulation by symbiont of entry into host" EXACT [] +synonym: "upregulation by symbiont of entry into host" EXACT [] +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:0075295 ! positive regulation by organism of entry into other organism during symbiotic interaction + +[Term] +id: GO:0075295 +name: positive regulation by organism of entry into other organism during symbiotic interaction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of entry into other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" EXACT [] +synonym: "upregulation by organism of entry into other organism during symbiotic interaction" EXACT [] +is_a: GO:0043902 ! positive regulation of multi-organism process +is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction + +[Term] +id: GO:0075296 +name: positive regulation of ascospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process by which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] +is_a: GO:0034307 ! regulation of ascospore formation +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0051781 ! positive regulation of cell division +relationship: positively_regulates GO:0030437 ! ascospore formation + +[Term] +id: GO:0075297 +name: negative regulation of ascospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ascospore formation, a process by which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] +is_a: GO:0034307 ! regulation of ascospore formation +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0051782 ! negative regulation of cell division +relationship: negatively_regulates GO:0030437 ! ascospore formation + +[Term] +id: GO:0075298 +name: regulation of zygospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process by which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0034296 ! zygospore formation + +[Term] +id: GO:0075299 +name: positive regulation of zygospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process by which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075298 ! regulation of zygospore formation +relationship: positively_regulates GO:0034296 ! zygospore formation + +[Term] +id: GO:0075300 +name: negative regulation of zygospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of zygospore formation, a process by which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075298 ! regulation of zygospore formation +relationship: negatively_regulates GO:0034296 ! zygospore formation + +[Term] +id: GO:0075301 +name: cell differentiation involved in spore germination +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009847 ! spore germination + +[Term] +id: GO:0075302 +name: regulation of basidiospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process by which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0034295 ! basidiospore formation + +[Term] +id: GO:0075303 +name: positive regulation of basidiospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process by which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075302 ! regulation of basidiospore formation + +[Term] +id: GO:0075304 +name: negative regulation of basidiospore formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of basidiospore formation, a process by which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075302 ! regulation of basidiospore formation +relationship: negatively_regulates GO:0034295 ! basidiospore formation + +[Term] +id: GO:0075305 +name: modulation of growth or development of symbiont on or near host +namespace: biological_process +def: "Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] +synonym: "modulation of growth or development of symbiont on or near host surface" EXACT [] +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: regulates GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075306 +name: regulation of conidium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0034305 ! regulation of asexual sporulation +relationship: regulates GO:0048315 ! conidium formation + +[Term] +id: GO:0075307 +name: positive regulation of conidium formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators] +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075306 ! regulation of conidium formation +relationship: positively_regulates GO:0048315 ! conidium formation + +[Term] +id: GO:0075308 +name: negative regulation of conidium formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators] +is_a: GO:0043939 ! negative regulation of sporulation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075306 ! regulation of conidium formation +relationship: negatively_regulates GO:0048315 ! conidium formation + +[Term] +id: GO:0075309 +name: negative regulation of growth or development of symbiont on or near host surface +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075310 +name: regulation of sporangium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0043582 ! sporangium development + +[Term] +id: GO:0075311 +name: positive regulation of sporangium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075310 ! regulation of sporangium development +relationship: positively_regulates GO:0043582 ! sporangium development + +[Term] +id: GO:0075312 +name: negative regulation of sporangium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075310 ! regulation of sporangium development +relationship: negatively_regulates GO:0043582 ! sporangium development + +[Term] +id: GO:0075313 +name: basidium development +namespace: biological_process +def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075314 +name: regulation of basidium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075313 ! basidium development + +[Term] +id: GO:0075315 +name: positive regulation of basidium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075314 ! regulation of basidium development +relationship: positively_regulates GO:0075313 ! basidium development + +[Term] +id: GO:0075316 +name: negative regulation of basidium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075314 ! regulation of basidium development +relationship: negatively_regulates GO:0075313 ! basidium development + +[Term] +id: GO:0075317 +name: ascus development +namespace: biological_process +def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing organ development + +[Term] +id: GO:0075318 +name: regulation of ascus development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075317 ! ascus development + +[Term] +id: GO:0075319 +name: positive regulation of ascus development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075318 ! regulation of ascus development +relationship: positively_regulates GO:0075317 ! ascus development + +[Term] +id: GO:0075320 +name: negative regulation of ascus development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075318 ! regulation of ascus development +relationship: negatively_regulates GO:0075317 ! ascus development + +[Term] +id: GO:0075321 +name: oomycete sporangium development +namespace: biological_process +def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0030436 ! asexual sporulation +is_a: GO:0043582 ! sporangium development + +[Term] +id: GO:0075322 +name: regulation of oomycete sporangium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0034305 ! regulation of asexual sporulation +is_a: GO:0075310 ! regulation of sporangium development +relationship: regulates GO:0075321 ! oomycete sporangium development + +[Term] +id: GO:0075323 +name: positive regulation of oomycete sporangium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0075311 ! positive regulation of sporangium development +is_a: GO:0075322 ! regulation of oomycete sporangium development +relationship: positively_regulates GO:0075321 ! oomycete sporangium development + +[Term] +id: GO:0075324 +name: negative regulation of oomycete sporangium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0043939 ! negative regulation of sporulation +is_a: GO:0075312 ! negative regulation of sporangium development +is_a: GO:0075322 ! regulation of oomycete sporangium development +relationship: negatively_regulates GO:0075321 ! oomycete sporangium development + +[Term] +id: GO:0075325 +name: spore dispersal on or near host +namespace: biological_process +def: "Any process by which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "spore dispersal on or near host during symbiotic interaction" EXACT [] +is_a: GO:0051701 ! interaction with host + +[Term] +id: GO:0075326 +name: active spore dispersal on or near host +namespace: biological_process +def: "Any active process by which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "active spore dispersal on or near host during symbiotic interaction" EXACT [] +is_a: GO:0075325 ! spore dispersal on or near host + +[Term] +id: GO:0075327 +name: passive spore dispersal on or near host +namespace: biological_process +def: "Any passive process by which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "passive spore dispersal on or near host during symbiotic interaction" EXACT [] +is_a: GO:0075325 ! spore dispersal on or near host + +[Term] +id: GO:0075328 +name: formation by symbiont of arbuscule for nutrient acquisition from host +namespace: biological_process +def: "The assembly by an organism of an arbuscule, a fine, tree-like hyphal structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host + +[Term] +id: GO:0075329 +name: regulation of arbuscule formation for nutrient acquisition from host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host + +[Term] +id: GO:0075330 +name: positive regulation of arbuscule formation for nutrient acquisition from host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host + +[Term] +id: GO:0075331 +name: negative regulation of arbuscule formation for nutrient acquisition from host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host +is_a: GO:0075340 ! negative regulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host + +[Term] +id: GO:0075332 +name: modulation by host of symbiont adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075335". +is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway +is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity + +[Term] +id: GO:0075333 +name: positive regulation by host of symbiont adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336". +is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway +is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction + +[Term] +id: GO:0075334 +name: modulation of symbiont adenylate cyclase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075147 ! regulation of signal transduction in response to host + +[Term] +id: GO:0075335 +name: positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075148 ! positive regulation of signal transduction in response to host +is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host + +[Term] +id: GO:0075336 +name: negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host +namespace: biological_process +def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +is_a: GO:0075149 ! negative regulation of signal transduction in response to host +is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host + +[Term] +id: GO:0075337 +name: positive regulation of growth or development of symbiont on or near host surface +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont adenylate cyclase-mediated signal transduction; GO:0075334". +is_a: GO:0075305 ! modulation of growth or development of symbiont on or near host +is_a: GO:0075335 ! positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host +is_a: GO:0075339 ! positive regulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0044408 ! growth or development of symbiont on or near host + +[Term] +id: GO:0075338 +name: modulation of growth or development of symbiont during interaction with host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] +is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism +is_a: GO:0044419 ! interspecies interaction between organisms +relationship: regulates GO:0052108 ! growth or development of symbiont during interaction with host + +[Term] +id: GO:0075339 +name: positive regulation of growth or development of symbiont during interaction with host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] +is_a: GO:0043902 ! positive regulation of multi-organism process +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: positively_regulates GO:0052108 ! growth or development of symbiont during interaction with host + +[Term] +id: GO:0075340 +name: negative regulation of growth or development of symbiont during interaction with host +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] +is_a: GO:0043901 ! negative regulation of multi-organism process +is_a: GO:0075338 ! modulation of growth or development of symbiont during interaction with host +relationship: negatively_regulates GO:0052108 ! growth or development of symbiont during interaction with host + +[Term] +id: GO:0075341 +name: host cell PML body +namespace: cellular_component +def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:jl] +synonym: "host cell PML NB" EXACT [] +synonym: "host cell PML nuclear body" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0042025 ! host cell nucleus + +[Term] +id: GO:0075342 +name: disassembly by symbiont of host cell PML body +namespace: biological_process +def: "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl] +synonym: "catabolism by symbiont of host cell PML body" EXACT [] +synonym: "degradation by symbiont of host cell PML body" EXACT [] +synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT [] +synonym: "disassembly by symbiont of host cell PML NB" EXACT [] +synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT [] +synonym: "disruption by symbiont of host cell PML body" EXACT [] +is_a: GO:0052008 ! disassembly by symbiont of host cellular component + +[Term] +id: GO:0075343 +name: modulation by symbiont of abscisic acid levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'. +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0075344 +name: modulation by symbiont of host protein levels +namespace: biological_process +def: "The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is intended for use in annotation of symbiont gene products. +is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction + +[Term] +id: GO:0075345 +name: modification by symbiont of host protein +namespace: biological_process +def: "The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that modify host proteins, consider annotation to 'protein modification process' GO:0006464. +is_a: GO:0052228 ! metabolism by symbiont of host protein + +[Term] +id: GO:0075346 +name: modification by symbiont of host protein by ubiquitination +namespace: biological_process +def: "The process by which an organism adds one or more ubiquitin moieties to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that ubiquitinate host proteins, consider annotation to 'protein ubiquitination ; GO:0016567'. +synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT [] +synonym: "modification by symbiont of host protein by ubiquitylation " EXACT [] +is_a: GO:0075345 ! modification by symbiont of host protein + +[Term] +id: GO:0080001 +name: mucilage extrusion from seed coat +namespace: biological_process +def: "The process by which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922] +synonym: "mucilage release from seed coat" RELATED [] +synonym: "secretion of mucilage from seed coat" RELATED [] +is_a: GO:0048609 ! reproductive process in a multicellular organism +relationship: part_of GO:0009845 ! seed germination +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0080002 +name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [EC:2.4.1.-, PMID:18385129] +synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED [] +synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED [] +synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED [] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080003 +name: thalianol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490] +synonym: "thalianol metabolism" EXACT [GOC:tair_curators] +is_a: GO:0010683 ! tricyclic triterpenoid metabolic process + +[Term] +id: GO:0080004 +name: thalian-diol desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0080005 +name: photosystem stoichiometry adjustment +namespace: biological_process +def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105] +is_a: GO:0010109 ! regulation of photosynthesis + +[Term] +id: GO:0080006 +name: internode patterning +namespace: biological_process +def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0048367 ! shoot development + +[Term] +id: GO:0080007 +name: S-nitrosoglutathione reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-nitrosoglutathione (GSNO) + NADH = GSNHOH + NAD, GSNHOH can be further metabolized to ammonia (NH3) and glutathione disulphide (GSSG)." [PMID:11260719] +is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor + +[Term] +id: GO:0080008 +name: CUL4 RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0080009 +name: mRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803] +is_a: GO:0001510 ! RNA methylation +is_a: GO:0016556 ! mRNA modification + +[Term] +id: GO:0080010 +name: regulation of oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006800 ! oxygen and reactive oxygen species metabolic process + +[Term] +id: GO:0080011 +name: baruol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol (D:B-Friedo-Baccharan-5,21-dien-3-ol)." [PMID:17705488] +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0080012 +name: N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine + S-adenosylmethionine = N',N''-bis(5-hydroxyferuloyl)-N'''-sinapoylspermidine." [PMID:18557837] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0080013 +name: (E,E)-geranyllinalool synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E,E,E)-geranylgeranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [PMID:18398052] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0080014 +name: thalianol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create thalian-diol((13R,14R,17E)-podioda-8,17,21-trien-3beta,?-diol). Several thalian-diol isomers may be created by the same enzyme because the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol (as indicated by the ''?'')." [PMID:17474751, PMID:18356490] +comment: In Field and Osbourn 2008 (PMID: 18356490), thalianol is referred to as (3S,13S, 3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S, 13S, 14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID: 17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008). +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0080015 +name: sabinene synthase activity +namespace: molecular_function +def: "Catalysis of the conversion of geranyl diphosphate (GPP) into the cyclic monoterpene sabinene." [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540] +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0080016 +name: (-)-E-beta-caryophyllene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047] +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0080017 +name: alpha-humulene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047] +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0080018 +name: anthocyanin 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction:anthocyanin + UDP-D-glucose = anthocyanin-5-O-glucoside + UDP." [PMID:15807784] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080019 +name: fatty acyl-CoA reductase (alcohol-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA." [PMID:16980563] +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0080020 +name: regulation of coenzyme A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051196 ! regulation of coenzyme metabolic process +relationship: regulates GO:0015937 ! coenzyme A biosynthetic process + +[Term] +id: GO:0080021 +name: response to benzoic acid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285] +is_a: GO:0042221 ! response to chemical stimulus + +[Term] +id: GO:0080022 +name: primary root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:DL] +is_a: GO:0048364 ! root development + +[Term] +id: GO:0080023 +name: 3R-hydroxyacyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0080024 +name: indolebutyric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356] +synonym: "IBA metabolic process" EXACT [] +synonym: "IBA metabolism" EXACT [] +synonym: "indole-3-butyric acid metabolic process" NARROW [] +is_a: GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0080025 +name: phosphatidylinositol-3,5-bisphosphate binding +namespace: molecular_function +def: "Interacting selectively with phosphatidylinositol-3,5-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [PMID:18397324] +synonym: "PtdIns(3,5)P2 binding" EXACT [] +is_a: GO:0035091 ! phosphoinositide binding + +[Term] +id: GO:0080026 +name: response to indolebutyric acid stimulus +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356] +synonym: "response to IBA stimulus" EXACT [] +synonym: "response to indole-3-butyric acid stimulus" NARROW [] +is_a: GO:0009733 ! response to auxin stimulus + +[Typedef] +id: negatively_regulates +name: negatively_regulates +is_a: regulates ! regulates + +[Typedef] +id: part_of +name: part_of +xref: OBO_REL:part_of +is_transitive: true + +[Typedef] +id: positively_regulates +name: positively_regulates +is_a: regulates ! regulates + +[Typedef] +id: regulates +name: regulates +transitive_over: part_of + diff --git a/forester/test_data/gene_tree_1.xml b/forester/test_data/gene_tree_1.xml new file mode 100644 index 0000000..ceac55f --- /dev/null +++ b/forester/test_data/gene_tree_1.xml @@ -0,0 +1,117 @@ + + + + + + + + + + + + + + + + + + MOUSE + + + + + RAT + + + + + + MOUSE + + + + + + CIOIN + + + + + + XENLA + + + + + + CHICK + + + + + + BRAFL + + + + + + LOTGI + + + + + + + + DROME + + + + + CAEEL + + + + + + STRPU + + + + + + + + NEMVE + + + + + BEROV + + + + + + + TRIAD + + + + + + MONBE + + + + + + YEAST + + + + + diff --git a/forester/test_data/gene_tree_2.xml b/forester/test_data/gene_tree_2.xml new file mode 100644 index 0000000..1158307 --- /dev/null +++ b/forester/test_data/gene_tree_2.xml @@ -0,0 +1,117 @@ + + + + + + + + + + + + + + + + + + HUMAN + + + + + RAT + + + + + + MOUSE + + + + + + CHICK + + + + + + XENLA + + + + + + BRAFL + + + + + + CIOIN + + + + + + LOTGI + + + + + + + + DROME + + + + + CAEEL + + + + + + STRPU + + + + + + + + NEMVE + + + + + TRIAD + + + + + + + BEROV + + + + + + MONBE + + + + + + YEAST + + + + + diff --git a/forester/test_data/hmmpfam_output b/forester/test_data/hmmpfam_output new file mode 100644 index 0000000..5cc6089 --- /dev/null +++ b/forester/test_data/hmmpfam_output @@ -0,0 +1,128 @@ +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: ENSP00000285681 +Accession: acc_ENSP00000285681 +Description: pep:known chromosome:NCBI36:21:16024215:16174248:1 gene:ENSG00000155313 transcript:ENST00000285681 + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- +UCH Ubiquitin carboxyl-terminal hydrolase 176.2 7.7e-50 1 +UIM Ubiquitin interaction motif 38.8 1.7e-08 2 +UBA UBA/TS-N domain 23.2 0.00084 1 + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +UBA 1/1 16 57 .. 1 41 [] 23.2 0.00084 +UIM 1/2 96 113 .. 1 18 [] 24.5 0.00035 +UIM 2/2 123 140 .. 1 18 [] 14.3 7.7e-50 +UCH 1/1 166 654 .. 1 318 [] 176.2 0.3 + +Alignments of top-scoring domains: +UBA: domain 1 of 1, from 16 to 57: score 23.2, E = 0.00084 + *->ideeavkqLreMTGf.dreeakkALeatngnverAvewLleh<-* + ++ + qLre TG +d + ++AL+ +ngn+e Av +L + + ENSP000002 16 HQQTFLNQLREITGInDTQILQQALKDSNGNLELAVAFLTAK 57 + +UIM: domain 1 of 2, from 96 to 113: score 24.5, E = 0.00035 + *->mdEEedLqlALalSlqea<-* + +d+ +dLq+A+alSl+e+ + ENSP000002 96 GDDKDDLQRAIALSLAES 113 + +UIM: domain 2 of 2, from 123 to 140: score 14.3, E = 0.3 + *->mdEEedLqlALalSlqea<-* + +dEE+ + + L+ S++e+ + ENSP000002 123 TDEEQAISRVLEASIAEN 140 + +UCH: domain 1 of 1, from 166 to 654: score 176.2, E = 7.7e-50 + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx + *->pgptGLvNlGNTCYmNSvLQcLfsipplrdyflsdsyesein...es + p+GL+N GNTC+ ++v+Q+Lf+ ++r+ +l++++ s ++ ++ + ENSP000002 166 KAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQdlpRN 212 + + RF xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx + nplgskgsllcaladLfnalqsg.yksvapsplkflqfkltlgkineefs + ++++++ + ++l+ Lf+ l ++k+v ps+ ++ +l+ +++ + + ENSP000002 213 QKEHRNLPFMRELRYLFALLVGTkRKYVDPSR-----AVEILKDAFKS-N 256 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx + gymQQDAhEFllfLLdgLhedlnrvnkkpytepessdkrpdkaa.eawkn + ++QQD+ EF LLd+L+++++ ka++e ++ + ENSP000002 257 DSQQQDVSEFTHKLLDWLEDAFQM-----------------KAEeETDE- 288 + + RF xxxxxxxxxxxxxxxxxxx + hltrnesiitdlFqGqlks............................... + ++ +++ ++lF G++ + ++++ ++++ ++ + + ++ ++ +++ + ENSP000002 289 --EKPKNPMVELFYGRFLAvgvlegkkfentemfgqyplqvngfkdlhec 336 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxx + .......................klkikrLPpvLiihLKRFsyngetgln + + +++ ++ ++++++++++ + ++ LPpvL++ L+RF++n +g++ + ENSP000002 337 leaamiegeieslhsensgksgqEHWFTELPPVLTFELSRFEFNQALGRP 386 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx xxxxxxxxxx + kKiddkVefPleLdlssycnaelkekevlrkd.ek.ieklkeerqr.... + +Ki++k+efP L+l++y+ ++ + ++r++ ++ ++ l++ +qr ++ + ENSP000002 387 EKIHNKLEFPQVLYLDRYMHRNREITRIKREEiKRlKDYLTVLQQRlery 436 + + RF + .................................................. + + ++++++ + + + + ++++ +++ ++ + +++++++ ++++ + ENSP000002 437 lsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqt 486 + + RF + .................................................. + ++++++++ +++ +++++++ ++++ +++ ++++ +++ + ++ + ENSP000002 487 lpstteqqgalsselpstspssvaaissrsvihkpftqsrippdlpmhpa 536 + + RF xxxxx xx xx + .......................................dedgn.ne.ee + +++ ++++ + ++ ++ +++ ++++++ +++ ++ +++ +++ +++ + + ENSP000002 537 prhiteeelsvlesclhrwrteiendtrdlqesisrihrTIELMySDkSM 586 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx + peeeekdneegenpptkYeLyaVvvHsGsslssGHYiayikkkkengkWy + + Y+L+aV+vH G +++ GHY+ayi + +++W + ENSP000002 587 -------------IQVPYRLHAVLVHEG-QANAGHYWAYIF-DHRESRWM 621 + + RF xxxxxxxxxxxxxxxxx xxxxxxxxxx + kfDDekVsevteeevle......rsssAYiLFY<-* + k++D V+ ++ ee +++ ++ r+ sAY L+Y + ENSP000002 622 KYNDIAVTKSSWEELVRdsfggyRNASAYCLMY 654 + +// + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: ENSP00000310334 +Accession: [none] +Description: pep:known chromosome:NCBI36:21:16364713:16901413:1 gene:ENSG00000174496 transcript:ENST00000308787 + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + [no hits above thresholds] + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- + [no hits above thresholds] + +Alignments of top-scoring domains: + [no hits above thresholds] +// diff --git a/forester/test_data/hmmpfam_output2 b/forester/test_data/hmmpfam_output2 new file mode 100644 index 0000000..0ed2001 --- /dev/null +++ b/forester/test_data/hmmpfam_output2 @@ -0,0 +1,612 @@ + +Query sequence: 1 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +A 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + +Query sequence: 2 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 3 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 4 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + + + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: 5 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: 6 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +Y 1/1 16 57 .. 1 41 [] 23.2 0.01 + + + +// + +Query sequence: 7 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +X 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 8 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +Z 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 9 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +U 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: 10 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +U 1/1 16 57 .. 1 41 [] 23.2 0.01 +U 1/1 16 57 .. 1 41 [] 23.2 0.01 +U 1/1 16 57 .. 1 41 [] 23.2 0.01 +U 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 11 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +V 1/1 16 57 .. 1 41 [] 23.2 0.01 +V 1/1 16 57 .. 1 41 [] 23.2 0.01 + +// + + +Query sequence: 12 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +W 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + + +Query sequence: 13 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +D 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 14 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 15 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + + +Query sequence: 16 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +Query sequence: 17 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + + +Query sequence: 18 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +D 1/1 16 57 .. 1 41 [] 23.2 0.01 +E 1/1 16 57 .. 1 41 [] 23.2 0.01 +X 1/1 16 57 .. 1 41 [] 23.2 0.01 +Y 1/1 16 57 .. 1 41 [] 23.2 0.01 +Z 1/1 16 57 .. 1 41 [] 23.2 0.01 +U 1/1 16 57 .. 1 41 [] 23.2 0.01 +V 1/1 16 57 .. 1 41 [] 23.2 0.01 +W 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + + +Query sequence: 19 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +NN 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + +Query sequence: 20 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +MM 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + +Query sequence: 21 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +MM 1/1 16 57 .. 1 41 [] 23.2 0.01 +OO 1/1 16 57 .. 1 41 [] 23.2 0.01 +OO 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + +Query sequence: 22 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +PP 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +Alignments of top-scoring domains: + +// + +Query sequence: 23 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +PP 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +Alignments of top-scoring domains: + +// + +Query sequence: 24 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + +Query sequence: 25 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + +Query sequence: 26 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// + +Query sequence: 27 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +QQ 1/1 16 57 .. 1 41 [] 23.2 0.01 + +Alignments of top-scoring domains: + +// +Query sequence: 28 +Accession: sdfjspdjfsjf +Description: sdf;smdf;ms;fdm +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +singlet 1/1 16 57 .. 1 41 [] 23.2 0.01 +// +Query sequence: 29 +Accession: sdfjspdjfsjf +Description: sdf;smdf;ms;fdm +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +three 1/3 16 57 .. 1 41 [] 23.2 0.01 +three 2/3 16 57 .. 1 41 [] 23.2 0.01 +three 3/3 16 57 .. 1 41 [] 23.2 0.01 +// \ No newline at end of file diff --git a/forester/test_data/hmmpfam_output3 b/forester/test_data/hmmpfam_output3 new file mode 100644 index 0000000..ab68357 --- /dev/null +++ b/forester/test_data/hmmpfam_output3 @@ -0,0 +1,178 @@ +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: ENSP00000285681 +Accession: acc_ENSP00000285681 +Description: pep:known chromosome:NCBI36:21:16024215:16174248:1 gene:ENSG00000155313 transcript:ENST00000285681 + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- +UCH Ubiquitin carboxyl-terminal hydrolase 176.2 7.7e-50 1 +UIM Ubiquitin interaction motif 38.8 1.7e-08 2 +UBA UBA/TS-N domain 23.2 0.00084 1 + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +UBA 1/1 16 57 .. 1 41 [] 23.2 0.00084 +UIM 1/2 96 113 .. 1 18 [] 24.5 0.00035 +UIM 2/2 123 140 .. 1 18 [] 14.3 7.7e-50 +UCH 1/1 166 654 .. 1 318 [] 176.2 0.3 + +Alignments of top-scoring domains: +UBA: domain 1 of 1, from 16 to 57: score 23.2, E = 0.00084 + *->ideeavkqLreMTGf.dreeakkALeatngnverAvewLleh<-* + ++ + qLre TG +d + ++AL+ +ngn+e Av +L + + ENSP000002 16 HQQTFLNQLREITGInDTQILQQALKDSNGNLELAVAFLTAK 57 + +UIM: domain 1 of 2, from 96 to 113: score 24.5, E = 0.00035 + *->mdEEedLqlALalSlqea<-* + +d+ +dLq+A+alSl+e+ + ENSP000002 96 GDDKDDLQRAIALSLAES 113 + +UIM: domain 2 of 2, from 123 to 140: score 14.3, E = 0.3 + *->mdEEedLqlALalSlqea<-* + +dEE+ + + L+ S++e+ + ENSP000002 123 TDEEQAISRVLEASIAEN 140 + +UCH: domain 1 of 1, from 166 to 654: score 176.2, E = 7.7e-50 + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx + *->pgptGLvNlGNTCYmNSvLQcLfsipplrdyflsdsyesein...es + p+GL+N GNTC+ ++v+Q+Lf+ ++r+ +l++++ s ++ ++ + ENSP000002 166 KAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQdlpRN 212 + + RF xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx + nplgskgsllcaladLfnalqsg.yksvapsplkflqfkltlgkineefs + ++++++ + ++l+ Lf+ l ++k+v ps+ ++ +l+ +++ + + ENSP000002 213 QKEHRNLPFMRELRYLFALLVGTkRKYVDPSR-----AVEILKDAFKS-N 256 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx + gymQQDAhEFllfLLdgLhedlnrvnkkpytepessdkrpdkaa.eawkn + ++QQD+ EF LLd+L+++++ ka++e ++ + ENSP000002 257 DSQQQDVSEFTHKLLDWLEDAFQM-----------------KAEeETDE- 288 + + RF xxxxxxxxxxxxxxxxxxx + hltrnesiitdlFqGqlks............................... + ++ +++ ++lF G++ + ++++ ++++ ++ + + ++ ++ +++ + ENSP000002 289 --EKPKNPMVELFYGRFLAvgvlegkkfentemfgqyplqvngfkdlhec 336 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxx + .......................klkikrLPpvLiihLKRFsyngetgln + + +++ ++ ++++++++++ + ++ LPpvL++ L+RF++n +g++ + ENSP000002 337 leaamiegeieslhsensgksgqEHWFTELPPVLTFELSRFEFNQALGRP 386 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx xxxxxxxxxx + kKiddkVefPleLdlssycnaelkekevlrkd.ek.ieklkeerqr.... + +Ki++k+efP L+l++y+ ++ + ++r++ ++ ++ l++ +qr ++ + ENSP000002 387 EKIHNKLEFPQVLYLDRYMHRNREITRIKREEiKRlKDYLTVLQQRlery 436 + + RF + .................................................. + + ++++++ + + + + ++++ +++ ++ + +++++++ ++++ + ENSP000002 437 lsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqt 486 + + RF + .................................................. + ++++++++ +++ +++++++ ++++ +++ ++++ +++ + ++ + ENSP000002 487 lpstteqqgalsselpstspssvaaissrsvihkpftqsrippdlpmhpa 536 + + RF xxxxx xx xx + .......................................dedgn.ne.ee + +++ ++++ + ++ ++ +++ ++++++ +++ ++ +++ +++ +++ + + ENSP000002 537 prhiteeelsvlesclhrwrteiendtrdlqesisrihrTIELMySDkSM 586 + + RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx + peeeekdneegenpptkYeLyaVvvHsGsslssGHYiayikkkkengkWy + + Y+L+aV+vH G +++ GHY+ayi + +++W + ENSP000002 587 -------------IQVPYRLHAVLVHEG-QANAGHYWAYIF-DHRESRWM 621 + + RF xxxxxxxxxxxxxxxxx xxxxxxxxxx + kfDDekVsevteeevle......rsssAYiLFY<-* + k++D V+ ++ ee +++ ++ r+ sAY L+Y + ENSP000002 622 KYNDIAVTKSSWEELVRdsfggyRNASAYCLMY 654 + +// + + + + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: 5 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +A 1/1 16 57 .. 1 41 [] 23.2 0.01 +B 1/1 16 57 .. 1 41 [] 23.2 0.01 +C 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// + +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: 6 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +Y 1/1 16 57 .. 1 41 [] 23.2 0.01 + + + +// + +Query sequence: 7 +Accession: [none] +Description: + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +C 1/1 16 57 .. 1 41 [] 23.2 0.01 +X 1/1 16 57 .. 1 41 [] 23.2 0.01 + + +// \ No newline at end of file diff --git a/forester/test_data/hmmpfam_output_short b/forester/test_data/hmmpfam_output_short new file mode 100644 index 0000000..c5f08a0 --- /dev/null +++ b/forester/test_data/hmmpfam_output_short @@ -0,0 +1,44 @@ +hmmpfam - search one or more sequences against HMM database +HMMER 2.3.2 (Oct 2003) +Copyright (C) 1992-2003 HHMI/Washington University School of Medicine +Freely distributed under the GNU General Public License (GPL) +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - +HMM file: /home/yye/db/pfam20.0/Pfam_ls +Sequence file: Human.fasta.1 +- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + +Query sequence: ENSP00000285681 +Accession: 223 +Description: pep:known chromosome:NCBI36:21:16024215:16174248:1 gene:ENSG00000155313 transcript:ENST00000285681 + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- +UCH Ubiquitin carboxyl-terminal hydrolase 176.2 7.7e-50 1 +UIM Ubiquitin interaction motif 38.8 1.7e-08 2 +UBA UBA/TS-N domain 23.2 0.00084 1 + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- +UBA 1/1 16 57 .. 1 41 [] 23.2 0.00084 +UIM 1/2 96 113 .. 1 18 [] 24.5 0.00035 +UIM 2/2 123 140 .. 1 18 [] 14.3 7.7e-50 +UCH 1/1 166 654 .. 1 318 [] 176.2 0.3 +// + +Query sequence: ENSP00000310334 +Accession: [none] +Description: pep:known chromosome:NCBI36:21:16364713:16901413:1 gene:ENSG00000174496 transcript:ENST00000308787 + +Scores for sequence family classification (score includes all domains): +Model Description Score E-value N +-------- ----------- ----- ------- --- + [no hits above thresholds] + +Parsed for domains: +Model Domain seq-f seq-t hmm-f hmm-t score E-value +-------- ------- ----- ----- ----- ----- ----- ------- + [no hits above thresholds] + +// diff --git a/forester/test_data/hmmscan30b3_output_1 b/forester/test_data/hmmscan30b3_output_1 new file mode 100644 index 0000000..88802c8 --- /dev/null +++ b/forester/test_data/hmmscan30b3_output_1 @@ -0,0 +1,2264 @@ +# --- full sequence --- -------------- this domain ------------- hmm coord ali coord env coord +# target name accession tlen query name accession qlen E-value score bias # of c-Evalue i-Evalue score bias from to from to from to acc description of target +#------------------- ---------- ----- -------------------- ---------- ----- --------- ------ ----- --- --- --------- --------- ------ ----- ----- ----- ----- ----- ----- ----- ---- --------------------- +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 1 9 4e-06 0.012 15.5 0.0 4 51 1 47 1 47 0.97 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 2 9 0.25 7.5e+02 0.1 0.0 1 12 50 61 50 63 0.84 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 3 9 0.081 2.4e+02 1.7 0.0 29 50 79 99 76 100 0.81 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 4 9 2.4e-16 7.2e-13 48.2 0.2 1 51 103 150 103 150 0.95 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 5 9 6.7e-18 2e-14 53.2 0.7 2 51 154 205 153 205 0.88 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 6 9 3.1e-12 9.4e-09 35.0 0.0 1 51 208 253 208 253 0.94 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 7 9 3.7e-10 1.1e-06 28.4 0.3 1 51 256 305 256 305 0.97 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 8 9 3e-09 9e-06 25.5 0.0 2 39 309 348 308 352 0.85 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 9 9 4 1.2e+04 -3.9 0.0 23 35 541 553 539 554 0.80 Regulator of chromosome condensation (RCC1) repeat +HECT PF00632.18 308 jgi|Monbr1|55|gw1.3.11.1 - 850 1.6e-56 191.4 0.0 1 1 8e-60 2.4e-56 190.8 0.0 22 301 562 830 533 833 0.84 HECT-domain (ubiquitin-transferase) +Cupin_2 PF07883.4 71 jgi|Monbr1|55|gw1.3.11.1 - 850 0.014 14.5 0.0 1 2 0.041 1.2e+02 1.9 0.0 21 37 42 59 33 65 0.80 Cupin domain +Cupin_2 PF07883.4 71 jgi|Monbr1|55|gw1.3.11.1 - 850 0.014 14.5 0.0 2 2 0.00017 0.5 9.6 0.0 26 57 255 287 248 297 0.87 Cupin domain +NHL PF01436.14 28 jgi|Monbr1|55|gw1.3.11.1 - 850 0.031 13.9 0.5 1 3 0.47 1.4e+03 -0.8 0.0 5 16 146 157 146 158 0.88 NHL repeat +NHL PF01436.14 28 jgi|Monbr1|55|gw1.3.11.1 - 850 0.031 13.9 0.5 2 3 0.018 54 3.7 0.0 2 16 198 212 197 212 0.89 NHL repeat +NHL PF01436.14 28 jgi|Monbr1|55|gw1.3.11.1 - 850 0.031 13.9 0.5 3 3 0.0054 16 5.3 0.1 5 17 301 313 301 313 0.97 NHL repeat +ABC_membrane PF00664.16 275 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.9e-58 197.7 23.2 1 2 2.9e-30 1.4e-27 96.4 9.2 4 274 70 335 67 336 0.89 ABC transporter transmembrane region +ABC_membrane PF00664.16 275 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.9e-58 197.7 23.2 2 2 1.7e-33 8.6e-31 107.0 1.5 1 273 731 1008 727 1010 0.93 ABC transporter transmembrane region +ABC_tran PF00005.20 118 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.4e-38 129.6 0.0 1 2 2.7e-18 1.4e-15 57.4 0.0 1 117 465 575 465 576 0.96 ABC transporter +ABC_tran PF00005.20 118 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.4e-38 129.6 0.0 2 2 4.4e-22 2.2e-19 69.6 0.0 1 118 1097 1221 1097 1221 0.95 ABC transporter +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 1 4 0.018 9 5.1 0.5 27 51 454 478 446 504 0.77 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 2 4 0.0062 3.1 6.6 0.0 120 210 514 618 493 625 0.76 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 3 4 0.5 2.5e+02 0.4 0.0 28 42 1087 1101 1072 1117 0.81 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 4 4 0.00028 0.14 11.0 0.0 135 209 1174 1262 1111 1268 0.78 RecF/RecN/SMC N terminal domain +Miro PF08477.6 119 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.9e-05 23.2 0.2 1 2 7.2e-05 0.036 14.2 0.0 2 37 454 483 454 526 0.69 Miro-like protein +Miro PF08477.6 119 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.9e-05 23.2 0.2 2 2 0.023 12 6.1 0.0 1 16 1085 1100 1085 1124 0.86 Miro-like protein +DUF258 PF03193.9 161 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00029 19.7 0.1 1 2 0.0011 0.53 9.1 0.1 35 67 451 483 441 487 0.88 Protein of unknown function, DUF258 +DUF258 PF03193.9 161 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00029 19.7 0.1 2 2 0.0024 1.2 8.0 0.0 36 68 1084 1116 1068 1142 0.72 Protein of unknown function, DUF258 +DUF87 PF01935.10 229 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00096 18.7 0.0 1 2 0.03 15 5.0 0.0 10 47 436 475 430 482 0.81 Domain of unknown function DUF87 +DUF87 PF01935.10 229 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00096 18.7 0.0 2 2 0.0005 0.25 10.8 0.0 25 47 1085 1107 1075 1115 0.83 Domain of unknown function DUF87 +ArgK PF03308.9 267 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0014 17.1 0.0 1 2 0.00086 0.42 9.0 0.0 17 54 439 476 422 490 0.81 ArgK protein +ArgK PF03308.9 267 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0014 17.1 0.0 2 2 0.0081 4 5.8 0.0 18 50 1072 1104 1064 1118 0.80 ArgK protein +Dynamin_N PF00350.16 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0029 17.1 0.0 1 2 2.2e-05 0.011 15.2 0.0 1 40 454 493 454 554 0.85 Dynamin family +Dynamin_N PF00350.16 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0029 17.1 0.0 2 2 6.6 3.3e+03 -2.6 0.0 1 15 1086 1100 1086 1105 0.84 Dynamin family +PRK PF00485.11 194 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0044 16.2 0.1 1 2 0.015 7.5 5.7 0.0 1 29 453 478 453 529 0.75 Phosphoribulokinase / Uridine kinase family +PRK PF00485.11 194 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0044 16.2 0.1 2 2 0.0025 1.2 8.2 0.0 2 24 1086 1108 1085 1132 0.86 Phosphoribulokinase / Uridine kinase family +FtsK_SpoIIIE PF01580.11 205 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0045 16.1 0.0 1 2 0.011 5.4 6.1 0.0 28 59 437 472 415 478 0.70 FtsK/SpoIIIE family +FtsK_SpoIIIE PF01580.11 205 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0045 16.1 0.0 2 2 0.0049 2.5 7.2 0.0 29 58 1074 1103 1060 1107 0.87 FtsK/SpoIIIE family +AAA PF00004.22 130 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0052 16.7 0.2 1 2 0.017 8.4 6.3 0.0 3 40 456 492 454 513 0.85 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0052 16.7 0.2 2 2 0.024 12 5.8 0.0 4 95 1089 1243 1086 1264 0.60 ATPase family associated with various cellular activities (AAA) +GSPII_E PF00437.13 282 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0055 15.3 0.0 1 2 0.0016 0.78 8.2 0.0 134 167 447 480 410 486 0.83 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0055 15.3 0.0 2 2 0.035 17 3.8 0.0 141 161 1086 1106 1071 1116 0.79 Type II/IV secretion system protein +NB-ARC PF00931.15 285 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.019 13.5 1.2 1 3 0.041 20 3.5 0.0 20 58 452 494 445 522 0.73 NB-ARC domain +NB-ARC PF00931.15 285 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.019 13.5 1.2 2 3 0.0075 3.7 6.0 0.0 22 40 1086 1104 1074 1112 0.84 NB-ARC domain +NB-ARC PF00931.15 285 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.019 13.5 1.2 3 3 0.34 1.7e+02 0.5 0.1 74 106 1216 1248 1204 1265 0.82 NB-ARC domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.02 13.5 0.0 1 2 0.0086 4.2 5.9 0.0 21 47 452 478 442 689 0.81 KAP family P-loop domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.02 13.5 0.0 2 2 0.019 9.4 4.8 0.0 23 107 1086 1262 1081 1271 0.71 KAP family P-loop domain +Zeta_toxin PF06414.5 201 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.072 11.8 0.7 1 2 0.0047 2.3 6.9 0.1 19 44 454 480 447 484 0.82 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.072 11.8 0.7 2 2 0.088 44 2.7 0.0 21 49 1088 1117 1085 1122 0.85 Zeta toxin +ATP-synt_ab PF00006.18 215 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.077 12.1 0.1 1 2 0.0076 3.8 6.6 0.0 8 43 444 479 440 659 0.85 ATP synthase alpha/beta family, nucleotide-binding domain +ATP-synt_ab PF00006.18 215 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.077 12.1 0.1 2 2 0.13 64 2.6 0.0 16 35 1084 1103 1078 1113 0.87 ATP synthase alpha/beta family, nucleotide-binding domain +Arch_ATPase PF01637.11 234 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.091 12.1 0.0 1 2 0.042 21 4.3 0.0 22 68 453 505 447 549 0.73 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.091 12.1 0.0 2 2 0.033 16 4.7 0.0 25 44 1088 1107 1082 1134 0.85 Archaeal ATPase +PTS_EIIC PF02378.11 321 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.11 11.0 4.2 1 3 0.71 3.5e+02 -0.6 0.0 68 127 60 112 57 123 0.81 Phosphotransferase system, EIIC +PTS_EIIC PF02378.11 321 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.11 11.0 4.2 2 3 1.6 8e+02 -1.7 0.0 223 274 725 795 695 807 0.54 Phosphotransferase system, EIIC +PTS_EIIC PF02378.11 321 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.11 11.0 4.2 3 3 0.00026 0.13 10.7 0.2 136 184 834 885 828 901 0.87 Phosphotransferase system, EIIC +MobB PF03205.7 137 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.12 11.8 0.6 1 2 0.018 8.9 5.8 0.1 3 26 454 477 452 484 0.86 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.12 11.8 0.6 2 2 0.071 35 3.8 0.0 3 22 1086 1105 1085 1111 0.83 Molybdopterin guanine dinucleotide synthesis protein B +DUF265 PF03266.8 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 11.6 0.5 1 2 0.21 1e+02 2.1 0.0 2 26 454 478 453 487 0.85 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 11.6 0.5 2 2 0.0072 3.6 6.9 0.0 1 26 1085 1110 1085 1128 0.78 Protein of unknown function, DUF265 +RNA_helicase PF00910.15 107 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 12.1 0.2 1 2 0.2 98 2.8 0.0 3 29 456 482 454 521 0.69 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 12.1 0.2 2 2 0.012 6.1 6.7 0.0 3 23 1088 1108 1086 1121 0.81 RNA helicase +CoaE PF01121.13 180 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.23 10.5 1.3 1 2 0.0065 3.2 6.7 0.1 2 24 453 476 452 496 0.78 Dephospho-CoA kinase +CoaE PF01121.13 180 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.23 10.5 1.3 2 2 0.21 1e+02 1.8 0.0 3 20 1086 1103 1085 1124 0.84 Dephospho-CoA kinase +NhaB PF06450.5 515 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.57 8.4 2.7 1 1 0.002 0.97 7.6 1.9 96 176 75 158 63 210 0.85 Bacterial Na+/H+ antiporter B (NhaB) +Pex24p PF06398.4 354 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.8 6.9 6.2 1 2 0.0035 1.7 7.0 0.1 134 202 174 245 151 282 0.81 Integral peroxisomal membrane peroxin +Pex24p PF06398.4 354 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.8 6.9 6.2 2 2 0.26 1.3e+02 0.8 1.7 44 156 861 976 856 994 0.66 Integral peroxisomal membrane peroxin +DNA_pol_B PF00136.14 467 jgi|Monbr1|107|gw1.5.19.1 - 1089 3.3e-120 401.7 0.3 1 1 1.2e-123 4.9e-120 401.1 0.2 1 464 475 932 475 935 0.90 DNA polymerase family B +DNA_pol_B_exo PF03104.12 317 jgi|Monbr1|107|gw1.5.19.1 - 1089 8.3e-40 136.3 0.0 1 1 3.1e-43 1.2e-39 135.7 0.0 3 316 51 395 49 396 0.92 DNA polymerase family B, exonuclease domain +zf-DNA_Pol PF08996.3 187 jgi|Monbr1|107|gw1.5.19.1 - 1089 1.3e-37 128.6 4.7 1 2 0.47 1.9e+03 -2.3 0.0 49 70 698 719 690 723 0.77 DNA Polymerase alpha zinc finger +zf-DNA_Pol PF08996.3 187 jgi|Monbr1|107|gw1.5.19.1 - 1089 1.3e-37 128.6 4.7 2 2 3.5e-41 1.4e-37 128.5 2.1 2 133 953 1088 952 1089 0.95 DNA Polymerase alpha zinc finger +PI3_PI4_kinase PF00454.20 235 jgi|Monbr1|169|gw1.2.38.1 - 846 2.6e-41 141.3 0.1 1 1 5.1e-44 3e-40 137.8 0.1 4 234 590 793 587 794 0.95 Phosphatidylinositol 3- and 4-kinase +PI3Ka PF00613.13 185 jgi|Monbr1|169|gw1.2.38.1 - 846 1.2e-23 82.9 0.1 1 1 4.7e-27 2.8e-23 81.7 0.1 43 182 341 474 323 479 0.84 Phosphoinositide 3-kinase family, accessory domain (PIK domain) +PDZ PF00595.17 81 jgi|Monbr1|209|gw1.4.39.1 - 664 5.7e-51 170.3 2.0 1 3 1.1e-19 3.3e-16 58.9 0.1 4 71 5 76 2 82 0.93 PDZ domain (Also known as DHR or GLGF) +PDZ PF00595.17 81 jgi|Monbr1|209|gw1.4.39.1 - 664 5.7e-51 170.3 2.0 2 3 2.3e-22 6.9e-19 67.5 0.1 2 81 95 179 94 179 0.97 PDZ domain (Also known as DHR or GLGF) +PDZ PF00595.17 81 jgi|Monbr1|209|gw1.4.39.1 - 664 5.7e-51 170.3 2.0 3 3 2.5e-14 7.6e-11 41.7 0.0 2 79 239 323 238 325 0.92 PDZ domain (Also known as DHR or GLGF) +Guanylate_kin PF00625.14 183 jgi|Monbr1|209|gw1.4.39.1 - 664 1.9e-48 164.0 0.0 1 1 1.3e-51 4e-48 162.9 0.0 2 181 480 654 479 656 0.98 Guanylate kinase +SH3_1 PF00018.21 48 jgi|Monbr1|209|gw1.4.39.1 - 664 1.8e-06 26.8 0.0 1 1 1.3e-09 3.8e-06 25.8 0.0 1 48 363 412 363 412 0.91 SH3 domain +DHFR_2 PF06442.4 78 jgi|Monbr1|209|gw1.4.39.1 - 664 0.1 11.9 0.0 1 2 0.00016 0.47 9.7 0.0 24 65 248 289 240 299 0.79 R67 dihydrofolate reductase +DHFR_2 PF06442.4 78 jgi|Monbr1|209|gw1.4.39.1 - 664 0.1 11.9 0.0 2 2 1.9 5.7e+03 -3.3 0.0 17 33 415 431 404 434 0.77 R67 dihydrofolate reductase +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 1 12 4 1.2e+04 -4.4 2.6 10 18 28 36 25 38 0.77 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 2 12 0.15 4.6e+02 0.6 0.3 4 10 91 97 76 97 0.80 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 3 12 0.00035 1 9.0 12.8 1 18 97 120 93 122 0.89 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 4 12 6.1e-06 0.018 14.6 8.2 1 18 160 177 160 178 0.97 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 5 12 9.5e-07 0.0028 17.2 12.5 1 18 223 240 223 242 0.97 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 6 12 1e-07 0.0003 20.3 12.5 1 20 286 304 286 304 0.96 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 7 12 2.6e-05 0.078 12.6 3.7 1 13 348 360 348 361 0.97 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 8 12 0.078 2.3e+02 1.5 0.2 4 10 372 378 371 379 0.92 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 9 12 0.029 86 2.9 8.0 5 18 387 401 384 403 0.85 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 10 12 0.0035 10 5.8 10.0 1 18 441 458 441 459 0.96 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 11 12 5.8e-06 0.017 14.7 3.1 1 15 494 508 494 510 0.95 NF-X1 type zinc finger +zf-NF-X1 PF01422.10 20 jgi|Monbr1|220|gw1.6.11.1 - 554 3.2e-11 42.6 195.5 12 12 0.0099 30 4.4 7.8 1 18 524 543 524 544 0.90 NF-X1 type zinc finger +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 1 8 2.4e-07 0.00071 18.9 2.1 13 50 8 44 3 47 0.89 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 2 8 4 1.2e+04 -8.7 9.7 17 52 93 130 57 131 0.78 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 3 8 4 1.2e+04 -6.8 9.4 17 44 150 176 143 188 0.65 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 4 8 4 1.2e+04 -7.3 5.7 33 42 227 237 211 246 0.61 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 5 8 2.3 6.8e+03 -3.5 8.7 24 53 279 313 266 313 0.81 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 6 8 4 1.2e+04 -5.5 3.4 17 31 338 353 315 359 0.58 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 7 8 4 1.2e+04 -7.0 9.2 16 42 373 397 372 416 0.85 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|220|gw1.6.11.1 - 554 0.00071 18.9 3.0 8 8 4 1.2e+04 -24.4 19.5 37 45 502 511 430 554 0.67 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 1 7 5.5e-06 0.016 14.9 0.8 2 30 8 37 7 37 0.95 C1-like domain +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 2 7 0.74 2.2e+03 -1.6 0.3 3 18 58 74 57 75 0.73 C1-like domain +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 3 7 4 1.2e+04 -3.9 0.9 18 27 174 183 173 186 0.52 C1-like domain +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 4 7 1.6 4.6e+03 -2.6 0.7 16 25 211 221 208 224 0.72 C1-like domain +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 5 7 0.65 1.9e+03 -1.4 0.2 4 17 399 411 399 419 0.71 C1-like domain +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 6 7 4 1.2e+04 -4.4 1.6 6 12 441 447 441 459 0.54 C1-like domain +C1_3 PF07649.5 30 jgi|Monbr1|220|gw1.6.11.1 - 554 0.016 14.9 1.1 7 7 4 1.2e+04 -4.1 1.0 5 10 523 528 523 532 0.75 C1-like domain +Peptidase_M24 PF00557.17 203 jgi|Monbr1|220|gw1.6.11.1 - 554 0.018 14.4 0.8 1 2 0.00013 0.39 10.0 0.5 45 117 145 214 123 235 0.69 Metallopeptidase family M24 +Peptidase_M24 PF00557.17 203 jgi|Monbr1|220|gw1.6.11.1 - 554 0.018 14.4 0.8 2 2 0.042 1.3e+02 1.8 0.0 143 161 518 537 502 550 0.73 Metallopeptidase family M24 +tRNA-synt_1e PF01406.12 301 jgi|Monbr1|223|gw1.5.33.1 - 667 3.5e-127 423.3 0.0 1 1 3.1e-130 5.2e-127 422.7 0.0 6 300 5 399 1 400 0.96 tRNA synthetases class I (C) catalytic domain +tRNA-synt_1g PF09334.4 391 jgi|Monbr1|223|gw1.5.33.1 - 667 3.1e-11 42.2 1.1 1 2 4.3e-06 0.0073 14.6 0.0 12 63 20 72 14 123 0.87 tRNA synthetases class I (M) +tRNA-synt_1g PF09334.4 391 jgi|Monbr1|223|gw1.5.33.1 - 667 3.1e-11 42.2 1.1 2 2 1.8e-09 3e-06 25.8 0.1 313 371 338 395 326 410 0.82 tRNA synthetases class I (M) +tRNA-synt_1 PF00133.15 601 jgi|Monbr1|223|gw1.5.33.1 - 667 6.1e-05 20.9 1.7 1 3 0.19 3.3e+02 -1.4 0.0 29 67 13 52 5 57 0.82 tRNA synthetases class I (I, L, M and V) +tRNA-synt_1 PF00133.15 601 jgi|Monbr1|223|gw1.5.33.1 - 667 6.1e-05 20.9 1.7 2 3 1e-07 0.00018 19.3 0.0 516 589 307 380 297 391 0.88 tRNA synthetases class I (I, L, M and V) +tRNA-synt_1 PF00133.15 601 jgi|Monbr1|223|gw1.5.33.1 - 667 6.1e-05 20.9 1.7 3 3 0.23 3.9e+02 -1.6 0.2 439 491 577 635 572 661 0.55 tRNA synthetases class I (I, L, M and V) +tRNA-synt_1f PF01921.11 360 jgi|Monbr1|223|gw1.5.33.1 - 667 0.0054 15.1 0.0 1 2 0.026 45 2.2 0.0 31 73 16 59 6 89 0.81 tRNA synthetases class I (K) +tRNA-synt_1f PF01921.11 360 jgi|Monbr1|223|gw1.5.33.1 - 667 0.0054 15.1 0.0 2 2 9.5e-05 0.16 10.2 0.0 278 323 349 393 335 426 0.77 tRNA synthetases class I (K) +tRNA-synt_1c PF00749.14 314 jgi|Monbr1|223|gw1.5.33.1 - 667 0.0072 14.7 1.1 1 2 7e-05 0.12 10.7 0.0 50 97 166 213 161 219 0.91 tRNA synthetases class I (E and Q), catalytic domain +tRNA-synt_1c PF00749.14 314 jgi|Monbr1|223|gw1.5.33.1 - 667 0.0072 14.7 1.1 2 2 0.049 84 1.3 0.6 102 152 576 613 561 633 0.62 tRNA synthetases class I (E and Q), catalytic domain +DUF1663 PF07909.4 497 jgi|Monbr1|223|gw1.5.33.1 - 667 0.67 8.0 2.6 1 1 0.00062 1 7.4 1.8 193 238 576 621 565 634 0.86 Protein of unknown function (DUF1663) +tRNA-synt_1d PF00750.12 354 jgi|Monbr1|223|gw1.5.33.1 - 667 1.8 7.0 4.2 1 3 0.027 47 2.3 0.0 33 60 20 48 13 81 0.86 tRNA synthetases class I (R) +tRNA-synt_1d PF00750.12 354 jgi|Monbr1|223|gw1.5.33.1 - 667 1.8 7.0 4.2 2 3 0.0032 5.5 5.3 0.0 174 211 194 231 135 236 0.67 tRNA synthetases class I (R) +tRNA-synt_1d PF00750.12 354 jgi|Monbr1|223|gw1.5.33.1 - 667 1.8 7.0 4.2 3 3 1.4 2.4e+03 -3.3 0.7 291 322 564 600 556 609 0.53 tRNA synthetases class I (R) +PMT PF02366.11 245 jgi|Monbr1|262|gw1.5.39.1 - 669 2.7e-50 170.7 13.6 1 1 1.4e-53 5.5e-50 169.6 9.4 3 243 10 255 8 256 0.93 Dolichyl-phosphate-mannose-protein mannosyltransferase +MIR PF02815.12 192 jgi|Monbr1|262|gw1.5.39.1 - 669 1e-13 50.9 0.0 1 1 4.3e-17 1.7e-13 50.2 0.0 3 186 307 496 305 502 0.84 MIR domain +ATPase_gene1 PF09527.3 61 jgi|Monbr1|262|gw1.5.39.1 - 669 0.69 9.4 3.6 1 2 0.00032 1.3 8.5 1.4 15 54 147 186 142 193 0.88 Putative F0F1-ATPase subunit (ATPase_gene1) +ATPase_gene1 PF09527.3 61 jgi|Monbr1|262|gw1.5.39.1 - 669 0.69 9.4 3.6 2 2 1.2 4.7e+03 -2.9 0.0 3 13 191 201 189 202 0.81 Putative F0F1-ATPase subunit (ATPase_gene1) +SNF2_N PF00176.16 297 jgi|Monbr1|323|gw1.2.79.1 - 470 1.6e-82 276.6 0.6 1 1 1e-85 3e-82 275.8 0.4 1 297 4 297 4 297 0.90 SNF2 family N-terminal domain +Helicase_C PF00271.24 78 jgi|Monbr1|323|gw1.2.79.1 - 470 4.5e-16 58.1 0.0 1 2 2.1 6.4e+03 -3.3 0.0 25 41 327 343 325 346 0.76 Helicase conserved C-terminal domain +Helicase_C PF00271.24 78 jgi|Monbr1|323|gw1.2.79.1 - 470 4.5e-16 58.1 0.0 2 2 4.9e-19 1.4e-15 56.5 0.0 1 78 353 432 353 432 0.97 Helicase conserved C-terminal domain +HDA2-3 PF11496.1 296 jgi|Monbr1|323|gw1.2.79.1 - 470 5.9e-10 38.1 0.1 1 1 5.1e-13 1.5e-09 36.7 0.1 10 260 235 462 229 468 0.77 Class II histone deacetylase complex subunits 2 and 3 +ResIII PF04851.8 184 jgi|Monbr1|323|gw1.2.79.1 - 470 0.00056 19.4 0.0 1 1 1.2e-05 0.036 13.5 0.0 7 182 4 152 1 154 0.64 Type III restriction enzyme, res subunit +Glyco_hydro_3 PF00933.14 227 jgi|Monbr1|337|gw1.3.61.1 - 521 5.1e-42 143.3 0.0 1 1 2.2e-45 8.9e-42 142.5 0.0 31 226 2 217 1 218 0.95 Glycosyl hydrolase family 3 N terminal domain +Glyco_hydro_3_C PF01915.15 211 jgi|Monbr1|337|gw1.3.61.1 - 521 2.5e-38 131.4 0.4 1 1 9.7e-42 3.8e-38 130.8 0.3 1 211 289 519 289 519 0.78 Glycosyl hydrolase family 3 C terminal domain +VASP PF11643.1 30 jgi|Monbr1|337|gw1.3.61.1 - 521 0.22 10.3 0.9 1 1 0.00011 0.44 9.4 0.6 8 18 366 376 362 377 0.86 Vasodilator-stimulated phosphoprotein VASP +Peptidase_M41 PF01434.11 213 jgi|Monbr1|340|gw1.4.53.1 - 442 1.1e-69 233.8 0.1 1 1 1.5e-72 1.5e-69 233.4 0.1 3 212 237 436 235 437 0.96 Peptidase family M41 +AAA PF00004.22 130 jgi|Monbr1|340|gw1.4.53.1 - 442 1e-41 141.8 0.0 1 1 2.3e-44 2.3e-41 140.7 0.0 2 128 39 170 38 172 0.97 ATPase family associated with various cellular activities (AAA) +AAA_5 PF07728.7 139 jgi|Monbr1|340|gw1.4.53.1 - 442 5.2e-05 22.6 0.0 1 1 2.5e-07 0.00025 20.4 0.0 3 79 39 108 37 161 0.81 AAA domain (dynein-related subfamily) +TIP49 PF06068.6 398 jgi|Monbr1|340|gw1.4.53.1 - 442 0.0007 18.1 0.1 1 1 1.4e-06 0.0014 17.0 0.0 51 88 36 71 27 77 0.88 TIP49 C-terminus +AAA_2 PF07724.7 171 jgi|Monbr1|340|gw1.4.53.1 - 442 0.00089 18.8 0.0 1 1 4.4e-06 0.0044 16.6 0.0 7 100 39 130 35 144 0.73 AAA domain (Cdc48 subfamily) +IstB PF01695.10 178 jgi|Monbr1|340|gw1.4.53.1 - 442 0.0022 17.1 0.1 1 1 6.1e-06 0.0061 15.6 0.1 50 71 38 59 33 74 0.90 IstB-like ATP binding protein +RuvB_N PF05496.5 234 jgi|Monbr1|340|gw1.4.53.1 - 442 0.0024 16.6 0.0 1 1 4.6e-06 0.0045 15.7 0.0 53 84 38 69 2 109 0.85 Holliday junction DNA helicase ruvB N-terminus +Zeta_toxin PF06414.5 201 jgi|Monbr1|340|gw1.4.53.1 - 442 0.0082 14.9 0.0 1 2 4.2e-05 0.041 12.6 0.0 15 53 34 71 25 106 0.85 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|340|gw1.4.53.1 - 442 0.0082 14.9 0.0 2 2 0.7 6.9e+02 -1.2 0.0 135 176 311 348 307 362 0.66 Zeta toxin +Mg_chelatase PF01078.14 207 jgi|Monbr1|340|gw1.4.53.1 - 442 0.018 13.9 0.2 1 1 3.9e-05 0.039 12.8 0.2 26 43 39 56 29 60 0.90 Magnesium chelatase, subunit ChlI +DUF265 PF03266.8 168 jgi|Monbr1|340|gw1.4.53.1 - 442 0.053 12.9 0.2 1 2 0.00024 0.24 10.7 0.0 3 32 39 68 38 75 0.86 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|340|gw1.4.53.1 - 442 0.053 12.9 0.2 2 2 2.3 2.3e+03 -2.2 0.0 90 104 88 103 76 105 0.74 Protein of unknown function, DUF265 +PhoH PF02562.9 205 jgi|Monbr1|340|gw1.4.53.1 - 442 0.085 11.7 0.3 1 1 0.00022 0.22 10.4 0.2 23 42 39 58 32 62 0.86 PhoH-like protein +CPT PF07931.5 174 jgi|Monbr1|340|gw1.4.53.1 - 442 0.11 11.7 0.2 1 3 0.0015 1.5 8.1 0.0 5 41 39 75 36 110 0.90 Chloramphenicol phosphotransferase-like protein +CPT PF07931.5 174 jgi|Monbr1|340|gw1.4.53.1 - 442 0.11 11.7 0.2 2 3 0.82 8.2e+02 -0.9 0.0 81 111 228 262 208 276 0.49 Chloramphenicol phosphotransferase-like protein +CPT PF07931.5 174 jgi|Monbr1|340|gw1.4.53.1 - 442 0.11 11.7 0.2 3 3 0.74 7.4e+02 -0.7 0.0 10 50 375 414 372 428 0.77 Chloramphenicol phosphotransferase-like protein +DEAD PF00270.22 167 jgi|Monbr1|387|gw1.8.56.1 - 498 6.6e-51 171.7 0.0 1 2 6.4e-53 3.8e-49 166.0 0.0 1 165 84 259 84 261 0.96 DEAD/DEAH box helicase +DEAD PF00270.22 167 jgi|Monbr1|387|gw1.8.56.1 - 498 6.6e-51 171.7 0.0 2 2 0.0058 35 3.5 0.0 48 102 312 367 280 381 0.81 DEAD/DEAH box helicase +Helicase_C PF00271.24 78 jgi|Monbr1|387|gw1.8.56.1 - 498 9e-25 86.0 0.0 1 2 0.56 3.4e+03 -2.4 0.0 1 27 158 184 158 188 0.82 Helicase conserved C-terminal domain +Helicase_C PF00271.24 78 jgi|Monbr1|387|gw1.8.56.1 - 498 9e-25 86.0 0.0 2 2 4.7e-28 2.8e-24 84.4 0.0 2 78 329 405 328 405 0.98 Helicase conserved C-terminal domain +Pkinase PF00069.18 260 jgi|Monbr1|409|gw1.3.73.1 - 499 2e-64 216.9 0.0 1 1 9.3e-68 2.8e-64 216.4 0.0 1 260 177 435 177 435 0.96 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|409|gw1.3.73.1 - 499 1.6e-34 118.8 0.0 1 1 7.8e-38 2.3e-34 118.3 0.0 2 249 178 418 177 421 0.89 Protein tyrosine kinase +C2 PF00168.23 85 jgi|Monbr1|409|gw1.3.73.1 - 499 3.1e-17 61.8 0.0 1 1 2.2e-20 6.5e-17 60.8 0.0 1 83 1 89 1 91 0.90 C2 domain +Pkinase_C PF00433.17 49 jgi|Monbr1|409|gw1.3.73.1 - 499 1.2e-07 31.6 2.1 1 1 7.9e-11 2.4e-07 30.6 1.4 5 47 459 499 455 499 0.94 Protein kinase C terminal domain +Rep_fac-A_C PF08646.3 146 jgi|Monbr1|451|gw1.4.73.1 - 540 4.5e-47 159.1 0.3 1 2 0.039 47 3.3 0.0 55 80 162 187 158 231 0.83 Replication factor-A C terminal domain +Rep_fac-A_C PF08646.3 146 jgi|Monbr1|451|gw1.4.73.1 - 540 4.5e-47 159.1 0.3 2 2 1.9e-48 2.3e-45 153.5 0.2 2 146 397 539 396 539 0.99 Replication factor-A C terminal domain +Rep-A_N PF04057.5 102 jgi|Monbr1|451|gw1.4.73.1 - 540 6.5e-14 51.2 0.8 1 2 2.5e-16 3e-13 49.1 0.7 44 101 2 59 1 60 0.93 Replication factor-A protein 1, N-terminal domain +Rep-A_N PF04057.5 102 jgi|Monbr1|451|gw1.4.73.1 - 540 6.5e-14 51.2 0.8 2 2 1.7 2.1e+03 -1.8 0.0 30 50 480 500 478 505 0.81 Replication factor-A protein 1, N-terminal domain +tRNA_anti PF01336.18 76 jgi|Monbr1|451|gw1.4.73.1 - 540 4.8e-10 38.8 0.2 1 3 0.17 2e+02 1.6 0.0 43 69 25 58 16 63 0.69 OB-fold nucleic acid binding domain +tRNA_anti PF01336.18 76 jgi|Monbr1|451|gw1.4.73.1 - 540 4.8e-10 38.8 0.2 2 3 1.2e-11 1.5e-08 34.0 0.0 2 72 139 223 138 227 0.93 OB-fold nucleic acid binding domain +tRNA_anti PF01336.18 76 jgi|Monbr1|451|gw1.4.73.1 - 540 4.8e-10 38.8 0.2 3 3 4.1 4.8e+03 -2.9 0.0 30 64 296 332 286 340 0.51 OB-fold nucleic acid binding domain +DUF1407 PF07191.5 70 jgi|Monbr1|451|gw1.4.73.1 - 540 0.019 14.4 2.7 1 1 3.2e-05 0.038 13.4 1.8 3 29 415 442 413 445 0.81 Protein of unknown function (DUF1407) +DUF223 PF02721.7 95 jgi|Monbr1|451|gw1.4.73.1 - 540 0.034 13.9 0.1 1 2 2.8 3.4e+03 -2.1 0.0 72 89 15 32 9 34 0.77 Domain of unknown function DUF223 +DUF223 PF02721.7 95 jgi|Monbr1|451|gw1.4.73.1 - 540 0.034 13.9 0.1 2 2 0.00012 0.15 11.8 0.0 48 81 210 243 172 252 0.83 Domain of unknown function DUF223 +Ribosomal_L37ae PF01780.12 90 jgi|Monbr1|451|gw1.4.73.1 - 540 0.14 11.7 0.4 1 1 0.00026 0.31 10.6 0.2 37 64 415 441 402 452 0.79 Ribosomal L37ae protein family +DUF2318 PF10080.2 102 jgi|Monbr1|451|gw1.4.73.1 - 540 0.16 11.4 0.5 1 1 0.00034 0.41 10.1 0.3 29 62 407 440 383 446 0.79 Predicted membrane protein (DUF2318) +Alpha_GJ PF03229.6 126 jgi|Monbr1|451|gw1.4.73.1 - 540 0.22 11.5 4.5 1 1 0.00046 0.54 10.2 3.1 31 88 64 128 48 131 0.45 Alphavirus glycoprotein J +Transposase_35 PF07282.4 69 jgi|Monbr1|451|gw1.4.73.1 - 540 0.27 10.6 2.1 1 2 5.4 6.4e+03 -3.5 0.0 16 32 283 299 276 305 0.77 Putative transposase DNA-binding domain +Transposase_35 PF07282.4 69 jgi|Monbr1|451|gw1.4.73.1 - 540 0.27 10.6 2.1 2 2 0.00036 0.43 9.9 0.9 29 54 414 438 404 441 0.92 Putative transposase DNA-binding domain +EGF_CA PF07645.8 42 jgi|Monbr1|451|gw1.4.73.1 - 540 0.51 10.0 3.2 1 1 0.0012 1.5 8.5 2.2 15 34 421 441 412 446 0.79 Calcium-binding EGF domain +OATP PF03137.13 540 jgi|Monbr1|460|gw1.5.71.1 - 402 2.3e-73 246.8 8.3 1 1 6.1e-75 8e-72 241.7 5.7 18 423 3 369 1 390 0.88 Organic Anion Transporter Polypeptide (OATP) family +MFS_1 PF07690.9 353 jgi|Monbr1|460|gw1.5.71.1 - 402 6.3e-24 84.0 25.0 1 1 7e-27 9.2e-24 83.5 17.3 11 297 3 341 1 381 0.81 Major Facilitator Superfamily +Nuc_H_symport PF03825.9 400 jgi|Monbr1|460|gw1.5.71.1 - 402 0.0096 14.4 0.1 1 1 1.6e-05 0.021 13.2 0.1 299 394 108 214 100 219 0.81 Nucleoside H+ symporter +Kazal_2 PF07648.8 42 jgi|Monbr1|460|gw1.5.71.1 - 402 0.015 14.8 2.8 1 1 2.1e-05 0.028 14.0 1.9 1 25 377 402 377 402 0.88 Kazal-type serine protease inhibitor domain +COX5C PF05799.5 62 jgi|Monbr1|460|gw1.5.71.1 - 402 0.059 12.6 0.9 1 2 0.29 3.9e+02 0.4 0.1 22 33 158 169 155 173 0.88 Cytochrome c oxidase subunit Vc (COX5C) +COX5C PF05799.5 62 jgi|Monbr1|460|gw1.5.71.1 - 402 0.059 12.6 0.9 2 2 0.00035 0.46 9.7 0.0 19 47 298 327 296 331 0.88 Cytochrome c oxidase subunit Vc (COX5C) +Cortexin PF11057.1 81 jgi|Monbr1|460|gw1.5.71.1 - 402 0.1 11.8 0.0 1 1 0.00016 0.21 10.9 0.0 29 71 324 367 316 373 0.67 Cortexin of kidney +DUF204 PF02659.8 67 jgi|Monbr1|460|gw1.5.71.1 - 402 0.24 11.2 11.8 1 3 0.05 66 3.4 0.6 20 65 16 63 5 81 0.75 Domain of unknown function DUF +DUF204 PF02659.8 67 jgi|Monbr1|460|gw1.5.71.1 - 402 0.24 11.2 11.8 2 3 0.012 15 5.4 0.1 22 60 145 199 128 205 0.61 Domain of unknown function DUF +DUF204 PF02659.8 67 jgi|Monbr1|460|gw1.5.71.1 - 402 0.24 11.2 11.8 3 3 0.0024 3.2 7.6 0.5 20 58 281 319 255 334 0.82 Domain of unknown function DUF +NADH_dehy_S2_C PF06444.4 56 jgi|Monbr1|460|gw1.5.71.1 - 402 0.41 10.6 3.0 1 1 0.0011 1.5 8.9 2.1 26 55 315 342 311 343 0.74 NADH dehydrogenase subunit 2 C-terminus +Toxin_4 PF00706.10 43 jgi|Monbr1|460|gw1.5.71.1 - 402 0.75 9.7 3.5 1 1 0.0016 2.2 8.2 2.4 1 28 374 401 374 402 0.95 Anenome neurotoxin +GTP_EFTU PF00009.20 189 jgi|Monbr1|476|gw1.6.34.1 - 430 6.8e-46 155.7 0.0 1 2 7.7e-49 1.5e-45 154.6 0.0 2 178 3 218 2 255 0.90 Elongation factor Tu GTP binding domain +GTP_EFTU PF00009.20 189 jgi|Monbr1|476|gw1.6.34.1 - 430 6.8e-46 155.7 0.0 2 2 1.4 2.8e+03 -2.8 0.0 92 111 382 401 379 405 0.87 Elongation factor Tu GTP binding domain +GTP_EFTU_D3 PF03143.10 101 jgi|Monbr1|476|gw1.6.34.1 - 430 1.8e-21 76.0 0.0 1 2 0.038 76 3.4 0.0 51 80 280 309 248 317 0.82 Elongation factor Tu C-terminal domain +GTP_EFTU_D3 PF03143.10 101 jgi|Monbr1|476|gw1.6.34.1 - 430 1.8e-21 76.0 0.0 2 2 6.6e-23 1.3e-19 70.0 0.0 2 100 319 428 318 429 0.96 Elongation factor Tu C-terminal domain +GTP_EFTU_D2 PF03144.18 74 jgi|Monbr1|476|gw1.6.34.1 - 430 2.4e-08 33.6 0.1 1 1 3.2e-11 6.3e-08 32.3 0.0 1 74 246 313 246 313 0.90 Elongation factor Tu domain 2 +FeoB_N PF02421.11 189 jgi|Monbr1|476|gw1.6.34.1 - 430 0.0084 15.0 0.0 1 2 0.24 4.7e+02 -0.5 0.0 2 21 6 25 5 49 0.73 Ferrous iron transport protein B +FeoB_N PF02421.11 189 jgi|Monbr1|476|gw1.6.34.1 - 430 0.0084 15.0 0.0 2 2 2.5e-05 0.049 12.5 0.0 32 60 67 95 65 116 0.89 Ferrous iron transport protein B +PipA PF07108.4 228 jgi|Monbr1|476|gw1.6.34.1 - 430 0.063 11.9 0.0 1 1 5.2e-05 0.1 11.2 0.0 55 96 135 177 126 185 0.82 PipA protein +PduV-EutP PF10662.2 143 jgi|Monbr1|476|gw1.6.34.1 - 430 0.14 11.2 0.6 1 3 0.026 51 3.0 0.0 3 19 6 22 4 34 0.86 Ethanolamine utilisation - propanediol utilisation +PduV-EutP PF10662.2 143 jgi|Monbr1|476|gw1.6.34.1 - 430 0.14 11.2 0.6 2 3 0.0034 6.8 5.8 0.0 39 76 85 118 74 163 0.88 Ethanolamine utilisation - propanediol utilisation +PduV-EutP PF10662.2 143 jgi|Monbr1|476|gw1.6.34.1 - 430 0.14 11.2 0.6 3 3 4.1 8.2e+03 -4.2 0.1 5 13 248 256 247 257 0.90 Ethanolamine utilisation - propanediol utilisation +Glyco_hydro_59 PF02057.8 669 jgi|Monbr1|480|gw1.8.65.1 - 624 6.2e-131 437.3 14.6 1 3 1.3e-104 7.9e-101 337.8 4.2 45 337 7 299 1 303 0.96 Glycosyl hydrolase family 59 +Glyco_hydro_59 PF02057.8 669 jgi|Monbr1|480|gw1.8.65.1 - 624 6.2e-131 437.3 14.6 2 3 1.3e-28 7.6e-25 86.7 0.0 336 531 323 522 316 526 0.88 Glycosyl hydrolase family 59 +Glyco_hydro_59 PF02057.8 669 jgi|Monbr1|480|gw1.8.65.1 - 624 6.2e-131 437.3 14.6 3 3 1.7e-07 0.001 16.9 0.8 576 664 527 623 524 624 0.85 Glycosyl hydrolase family 59 +Glyco_hydro_30 PF02055.9 496 jgi|Monbr1|480|gw1.8.65.1 - 624 0.02 12.7 0.4 1 2 1.7e-05 0.1 10.4 0.0 156 182 77 103 52 111 0.85 O-Glycosyl hydrolase family 30 +Glyco_hydro_30 PF02055.9 496 jgi|Monbr1|480|gw1.8.65.1 - 624 0.02 12.7 0.4 2 2 0.033 2e+02 -0.4 0.1 370 427 246 301 218 311 0.76 O-Glycosyl hydrolase family 30 +CPL PF08144.4 148 jgi|Monbr1|506|gw1.2.108.1 - 408 2.5e-23 82.2 0.1 1 2 0.44 2.6e+03 -2.2 0.0 44 62 220 238 186 245 0.58 CPL (NUC119) domain +CPL PF08144.4 148 jgi|Monbr1|506|gw1.2.108.1 - 408 2.5e-23 82.2 0.1 2 2 2.2e-26 1.3e-22 79.8 0.0 2 97 313 408 312 408 0.98 CPL (NUC119) domain +PUF PF00806.12 35 jgi|Monbr1|506|gw1.2.108.1 - 408 0.0024 16.9 0.1 1 6 0.0026 15 4.9 0.0 16 34 60 78 59 79 0.91 Pumilio-family RNA binding repeat +PUF PF00806.12 35 jgi|Monbr1|506|gw1.2.108.1 - 408 0.0024 16.9 0.1 2 6 0.085 5.1e+02 0.1 0.0 2 30 82 110 81 115 0.79 Pumilio-family RNA binding repeat +PUF PF00806.12 35 jgi|Monbr1|506|gw1.2.108.1 - 408 0.0024 16.9 0.1 3 6 0.25 1.5e+03 -1.3 0.0 2 19 118 135 117 135 0.85 Pumilio-family RNA binding repeat +PUF PF00806.12 35 jgi|Monbr1|506|gw1.2.108.1 - 408 0.0024 16.9 0.1 4 6 0.29 1.7e+03 -1.6 0.0 22 32 250 260 249 263 0.84 Pumilio-family RNA binding repeat +PUF PF00806.12 35 jgi|Monbr1|506|gw1.2.108.1 - 408 0.0024 16.9 0.1 5 6 1.3 8e+03 -3.6 0.0 1 10 265 274 265 275 0.85 Pumilio-family RNA binding repeat +PUF PF00806.12 35 jgi|Monbr1|506|gw1.2.108.1 - 408 0.0024 16.9 0.1 6 6 0.0037 22 4.4 0.0 1 15 303 317 303 321 0.87 Pumilio-family RNA binding repeat +ABC_tran PF00005.20 118 jgi|Monbr1|515|gw1.6.38.1 - 481 4.7e-31 107.3 0.5 1 3 1.9e-15 7.4e-13 48.5 0.0 64 118 75 149 12 149 0.77 ABC transporter +ABC_tran PF00005.20 118 jgi|Monbr1|515|gw1.6.38.1 - 481 4.7e-31 107.3 0.5 2 3 5.4 2.1e+03 -1.3 0.0 64 72 225 233 186 291 0.55 ABC transporter +ABC_tran PF00005.20 118 jgi|Monbr1|515|gw1.6.38.1 - 481 4.7e-31 107.3 0.5 3 3 1.2e-17 4.6e-15 55.7 0.0 1 118 327 433 327 433 0.87 ABC transporter +SMC_N PF02463.12 220 jgi|Monbr1|515|gw1.6.38.1 - 481 3.4e-15 55.5 0.0 1 3 2.3e-09 9e-07 28.0 0.0 30 204 4 182 2 194 0.82 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|515|gw1.6.38.1 - 481 3.4e-15 55.5 0.0 2 3 0.00088 0.35 9.7 0.0 27 44 316 333 305 341 0.85 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|515|gw1.6.38.1 - 481 3.4e-15 55.5 0.0 3 3 6.2e-05 0.024 13.5 0.0 131 208 399 471 379 479 0.80 RecF/RecN/SMC N terminal domain +AAA PF00004.22 130 jgi|Monbr1|515|gw1.6.38.1 - 481 1.3e-05 25.1 0.0 1 2 0.00081 0.32 10.9 0.0 3 35 3 50 1 166 0.73 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|515|gw1.6.38.1 - 481 1.3e-05 25.1 0.0 2 2 0.0024 0.94 9.4 0.0 3 35 318 352 316 430 0.82 ATPase family associated with various cellular activities (AAA) +DUF87 PF01935.10 229 jgi|Monbr1|515|gw1.6.38.1 - 481 2e-05 24.2 0.0 1 2 0.13 53 3.2 0.0 32 60 7 37 2 100 0.84 Domain of unknown function DUF87 +DUF87 PF01935.10 229 jgi|Monbr1|515|gw1.6.38.1 - 481 2e-05 24.2 0.0 2 2 4.7e-06 0.0019 17.7 0.0 15 56 307 344 299 359 0.82 Domain of unknown function DUF87 +NACHT PF05729.5 166 jgi|Monbr1|515|gw1.6.38.1 - 481 2.4e-05 23.6 0.3 1 2 0.0027 1.1 8.5 0.0 6 20 4 18 3 36 0.85 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|515|gw1.6.38.1 - 481 2.4e-05 23.6 0.3 2 2 0.00024 0.097 11.9 0.4 3 27 316 340 314 472 0.74 NACHT domain +DUF258 PF03193.9 161 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00013 20.9 0.2 1 3 0.0054 2.2 7.1 0.0 40 59 3 22 1 73 0.87 Protein of unknown function, DUF258 +DUF258 PF03193.9 161 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00013 20.9 0.2 2 3 2.4 9.6e+02 -1.5 0.1 139 160 213 234 187 235 0.80 Protein of unknown function, DUF258 +DUF258 PF03193.9 161 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00013 20.9 0.2 3 3 0.00057 0.23 10.3 0.0 38 79 316 359 298 376 0.73 Protein of unknown function, DUF258 +MobB PF03205.7 137 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00018 21.0 0.1 1 2 0.002 0.79 9.2 0.0 4 20 2 18 1 26 0.88 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00018 21.0 0.1 2 2 0.0026 1.1 8.8 0.0 3 24 316 337 315 353 0.85 Molybdopterin guanine dinucleotide synthesis protein B +Zeta_toxin PF06414.5 201 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00021 20.1 0.1 1 3 0.15 61 2.3 0.0 23 38 5 20 3 36 0.86 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00021 20.1 0.1 2 3 2.3 9.3e+02 -1.6 0.0 52 86 212 233 182 291 0.65 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00021 20.1 0.1 3 3 2.8e-05 0.011 14.5 0.0 21 50 318 348 313 375 0.87 Zeta toxin +ArgK PF03308.9 267 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00063 18.2 0.1 1 3 0.022 8.6 4.7 0.0 33 53 2 22 1 26 0.87 ArgK protein +ArgK PF03308.9 267 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00063 18.2 0.1 2 3 2.1 8.1e+02 -1.8 0.0 9 65 224 280 216 287 0.66 ArgK protein +ArgK PF03308.9 267 jgi|Monbr1|515|gw1.6.38.1 - 481 0.00063 18.2 0.1 3 3 0.00039 0.16 10.4 0.0 14 54 298 338 288 346 0.82 ArgK protein +Miro PF08477.6 119 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0011 19.1 0.0 1 2 0.023 9.1 6.4 0.0 5 41 4 36 2 70 0.68 Miro-like protein +Miro PF08477.6 119 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0011 19.1 0.0 2 2 0.0028 1.1 9.4 0.0 1 23 315 337 315 369 0.78 Miro-like protein +NB-ARC PF00931.15 285 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0013 17.3 0.0 1 2 0.04 16 3.9 0.0 24 41 3 20 1 32 0.86 NB-ARC domain +NB-ARC PF00931.15 285 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0013 17.3 0.0 2 2 0.00027 0.11 11.0 0.0 21 43 315 337 303 396 0.85 NB-ARC domain +FtsK_SpoIIIE PF01580.11 205 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0016 17.6 0.0 1 2 0.014 5.6 6.0 0.0 45 117 5 73 3 132 0.71 FtsK/SpoIIIE family +FtsK_SpoIIIE PF01580.11 205 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0016 17.6 0.0 2 2 0.0013 0.51 9.4 0.0 28 63 303 338 264 341 0.76 FtsK/SpoIIIE family +DUF815 PF05673.6 250 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0016 17.0 0.0 1 3 0.066 26 3.3 0.0 59 80 4 25 3 51 0.78 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0016 17.0 0.0 2 3 9.9 3.9e+03 -3.9 0.0 206 235 215 244 200 247 0.59 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0016 17.0 0.0 3 3 0.00032 0.13 10.8 0.0 52 90 312 349 280 358 0.84 Protein of unknown function (DUF815) +Arch_ATPase PF01637.11 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0019 17.6 0.2 1 4 0.0042 1.6 8.0 0.0 27 44 5 22 3 87 0.76 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0019 17.6 0.2 2 4 5.5 2.2e+03 -2.2 0.1 157 186 167 197 161 235 0.57 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0019 17.6 0.2 3 4 3.6 1.4e+03 -1.6 0.1 51 88 203 240 190 278 0.64 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0019 17.6 0.2 4 4 0.018 7 5.9 0.0 25 44 318 337 312 361 0.89 Archaeal ATPase +RNA_helicase PF00910.15 107 jgi|Monbr1|515|gw1.6.38.1 - 481 0.002 17.9 0.0 1 2 0.016 6.4 6.6 0.0 3 23 3 23 2 70 0.82 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|515|gw1.6.38.1 - 481 0.002 17.9 0.0 2 2 0.0032 1.3 8.9 0.0 3 26 318 341 316 372 0.75 RNA helicase +AAA_5 PF07728.7 139 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0029 17.0 0.2 1 3 0.044 17 4.7 0.0 5 19 4 18 3 27 0.86 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0029 17.0 0.2 2 3 5.6 2.2e+03 -2.1 0.0 47 47 127 127 77 165 0.60 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0029 17.0 0.2 3 3 0.0025 0.98 8.8 0.0 2 35 316 351 315 356 0.80 AAA domain (dynein-related subfamily) +MutS_V PF00488.14 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0034 16.5 0.0 1 2 0.0099 3.9 6.4 0.0 49 63 5 19 3 24 0.88 MutS domain V +MutS_V PF00488.14 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0034 16.5 0.0 2 2 0.0047 1.9 7.5 0.0 12 60 278 331 269 337 0.81 MutS domain V +cobW PF02492.12 173 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0038 16.3 0.2 1 2 0.005 2 7.5 0.0 5 22 3 20 1 43 0.81 CobW/HypB/UreG, nucleotide-binding domain +cobW PF02492.12 173 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0038 16.3 0.2 2 2 0.014 5.7 6.0 0.1 4 20 317 333 315 344 0.82 CobW/HypB/UreG, nucleotide-binding domain +Dynamin_N PF00350.16 168 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0057 16.1 0.2 1 3 0.013 5.1 6.5 0.0 3 23 3 23 2 33 0.87 Dynamin family +Dynamin_N PF00350.16 168 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0057 16.1 0.2 2 3 5.8 2.3e+03 -2.1 0.0 62 79 210 227 159 249 0.48 Dynamin family +Dynamin_N PF00350.16 168 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0057 16.1 0.2 3 3 0.014 5.6 6.4 0.0 1 22 316 336 316 347 0.77 Dynamin family +ATP_bind_1 PF03029.10 238 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0061 15.8 0.0 1 2 0.001 0.42 9.8 0.0 2 21 4 23 3 29 0.89 Conserved hypothetical ATP binding protein +ATP_bind_1 PF03029.10 238 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0061 15.8 0.0 2 2 0.094 37 3.4 0.0 2 16 319 333 318 349 0.83 Conserved hypothetical ATP binding protein +KAP_NTPase PF07693.7 325 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0076 14.9 0.0 1 3 0.57 2.3e+02 0.2 0.0 30 42 8 20 4 141 0.88 KAP family P-loop domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0076 14.9 0.0 2 3 1.7 6.6e+02 -1.3 0.0 237 271 199 234 153 277 0.57 KAP family P-loop domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|515|gw1.6.38.1 - 481 0.0076 14.9 0.0 3 3 0.00023 0.09 11.4 0.0 23 45 316 338 302 422 0.92 KAP family P-loop domain +PduV-EutP PF10662.2 143 jgi|Monbr1|515|gw1.6.38.1 - 481 0.011 14.8 0.1 1 3 0.024 9.7 5.3 0.0 6 27 3 24 2 45 0.84 Ethanolamine utilisation - propanediol utilisation +PduV-EutP PF10662.2 143 jgi|Monbr1|515|gw1.6.38.1 - 481 0.011 14.8 0.1 2 3 2.4 9.5e+02 -1.1 0.0 79 119 33 75 25 82 0.79 Ethanolamine utilisation - propanediol utilisation +PduV-EutP PF10662.2 143 jgi|Monbr1|515|gw1.6.38.1 - 481 0.011 14.8 0.1 3 3 0.018 7.2 5.7 0.0 4 24 316 336 314 341 0.87 Ethanolamine utilisation - propanediol utilisation +DUF265 PF03266.8 168 jgi|Monbr1|515|gw1.6.38.1 - 481 0.022 14.1 0.1 1 2 0.16 64 2.8 0.0 6 20 5 19 2 25 0.87 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|515|gw1.6.38.1 - 481 0.022 14.1 0.1 2 2 0.0031 1.2 8.4 0.0 1 24 315 338 315 345 0.88 Protein of unknown function, DUF265 +ABC_ATPase PF09818.2 448 jgi|Monbr1|515|gw1.6.38.1 - 481 0.048 11.9 0.0 1 2 0.0029 1.1 7.3 0.0 250 284 4 38 3 43 0.86 Predicted ATPase of the ABC class +ABC_ATPase PF09818.2 448 jgi|Monbr1|515|gw1.6.38.1 - 481 0.048 11.9 0.0 2 2 0.18 71 1.4 0.1 249 265 318 334 313 337 0.87 Predicted ATPase of the ABC class +Thymidylate_kin PF02223.10 186 jgi|Monbr1|515|gw1.6.38.1 - 481 0.05 12.6 0.7 1 3 0.085 34 3.4 0.0 3 19 5 21 3 28 0.86 Thymidylate kinase +Thymidylate_kin PF02223.10 186 jgi|Monbr1|515|gw1.6.38.1 - 481 0.05 12.6 0.7 2 3 1.6 6.2e+02 -0.7 0.3 136 161 215 239 204 264 0.51 Thymidylate kinase +Thymidylate_kin PF02223.10 186 jgi|Monbr1|515|gw1.6.38.1 - 481 0.05 12.6 0.7 3 3 0.019 7.4 5.5 0.0 3 21 320 338 318 344 0.89 Thymidylate kinase +Mg_chelatase PF01078.14 207 jgi|Monbr1|515|gw1.6.38.1 - 481 0.072 11.9 0.2 1 3 0.12 47 2.7 0.0 27 42 3 18 2 32 0.84 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|515|gw1.6.38.1 - 481 0.072 11.9 0.2 2 3 5 2e+03 -2.6 0.0 109 138 141 171 101 182 0.76 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|515|gw1.6.38.1 - 481 0.072 11.9 0.2 3 3 0.013 5.3 5.8 0.0 24 65 315 356 306 371 0.74 Magnesium chelatase, subunit ChlI +YflT PF11181.1 103 jgi|Monbr1|515|gw1.6.38.1 - 481 0.085 12.7 0.4 1 3 9.4 3.7e+03 -2.3 0.0 68 83 95 110 63 118 0.65 Heat induced stress protein YflT +YflT PF11181.1 103 jgi|Monbr1|515|gw1.6.38.1 - 481 0.085 12.7 0.4 2 3 0.08 32 4.4 0.1 29 96 170 236 152 237 0.74 Heat induced stress protein YflT +YflT PF11181.1 103 jgi|Monbr1|515|gw1.6.38.1 - 481 0.085 12.7 0.4 3 3 0.048 19 5.1 0.0 35 85 347 397 343 400 0.84 Heat induced stress protein YflT +GSPII_E PF00437.13 282 jgi|Monbr1|515|gw1.6.38.1 - 481 0.088 11.3 0.9 1 3 0.036 14 4.1 0.0 144 158 4 18 3 31 0.89 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|515|gw1.6.38.1 - 481 0.088 11.3 0.9 2 3 7.2 2.9e+03 -3.5 0.1 113 137 216 240 211 243 0.81 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|515|gw1.6.38.1 - 481 0.088 11.3 0.9 3 3 0.02 7.8 4.9 0.0 143 165 318 340 281 359 0.84 Type II/IV secretion system protein +RuvB_N PF05496.5 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.17 10.6 0.8 1 2 3.5 1.4e+03 -2.2 0.0 55 71 3 19 3 25 0.83 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|515|gw1.6.38.1 - 481 0.17 10.6 0.8 2 2 0.0011 0.43 9.2 0.0 39 75 302 338 294 346 0.88 Holliday junction DNA helicase ruvB N-terminus +DUF3584 PF12128.1 1202 jgi|Monbr1|515|gw1.6.38.1 - 481 0.25 8.3 8.6 1 3 0.16 65 0.3 0.1 24 37 5 18 3 19 0.90 Protein of unknown function (DUF3584) +DUF3584 PF12128.1 1202 jgi|Monbr1|515|gw1.6.38.1 - 481 0.25 8.3 8.6 2 3 0.24 96 -0.3 0.5 603 641 210 248 185 278 0.53 Protein of unknown function (DUF3584) +DUF3584 PF12128.1 1202 jgi|Monbr1|515|gw1.6.38.1 - 481 0.25 8.3 8.6 3 3 7.7e-05 0.031 11.3 0.1 13 37 309 333 305 334 0.94 Protein of unknown function (DUF3584) +Pkinase PF00069.18 260 jgi|Monbr1|532|gw1.8.70.1 - 488 1.2e-38 132.4 0.1 1 2 1.9e-23 5.7e-20 71.2 0.1 1 132 27 169 27 178 0.89 Protein kinase domain +Pkinase PF00069.18 260 jgi|Monbr1|532|gw1.8.70.1 - 488 1.2e-38 132.4 0.1 2 2 9.4e-20 2.8e-16 59.1 0.0 134 260 322 486 315 486 0.94 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|532|gw1.8.70.1 - 488 1.5e-09 37.1 0.3 1 2 5.3e-09 1.6e-05 23.8 0.1 3 137 29 169 27 187 0.75 Protein tyrosine kinase +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|532|gw1.8.70.1 - 488 1.5e-09 37.1 0.3 2 2 3.7e-05 0.11 11.2 0.0 142 201 325 379 317 391 0.77 Protein tyrosine kinase +Pox_ser-thr_kin PF05445.4 434 jgi|Monbr1|532|gw1.8.70.1 - 488 0.0037 15.7 0.0 1 1 1.9e-06 0.0055 15.2 0.0 296 332 152 188 120 192 0.76 Poxvirus serine/threonine protein kinase +APH PF01636.16 238 jgi|Monbr1|532|gw1.8.70.1 - 488 0.17 11.2 0.5 1 3 0.0055 17 4.7 0.0 4 59 32 96 29 135 0.75 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|532|gw1.8.70.1 - 488 0.17 11.2 0.5 2 3 0.01 30 3.9 0.0 163 180 152 169 128 176 0.74 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|532|gw1.8.70.1 - 488 0.17 11.2 0.5 3 3 0.8 2.4e+03 -2.4 0.1 96 153 212 228 185 313 0.57 Phosphotransferase enzyme family +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 1 7 6.7e-06 0.013 15.0 0.0 4 33 3 32 1 33 0.92 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 2 7 0.00062 1.2 8.8 0.1 2 33 35 66 34 67 0.90 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 3 7 1.2 2.4e+03 -1.4 0.0 18 28 75 85 74 85 0.86 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 4 7 0.0001 0.2 11.3 0.0 1 32 278 309 278 311 0.91 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 5 7 9.4e-06 0.019 14.5 0.0 1 27 318 344 318 345 0.93 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 6 7 0.00057 1.1 9.0 0.3 5 27 359 381 356 387 0.86 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|542|gw1.3.102.1 - 437 3.4e-16 57.4 18.8 7 7 0.0028 5.5 6.8 0.3 4 31 398 425 396 428 0.82 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|542|gw1.3.102.1 - 437 8.8e-16 56.4 8.2 1 6 3.6e-05 0.072 12.4 0.0 10 34 9 33 3 33 0.96 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|542|gw1.3.102.1 - 437 8.8e-16 56.4 8.2 2 6 0.0002 0.4 10.0 0.0 3 33 36 66 35 67 0.92 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|542|gw1.3.102.1 - 437 8.8e-16 56.4 8.2 3 6 0.00063 1.3 8.4 0.0 1 33 278 310 278 311 0.92 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|542|gw1.3.102.1 - 437 8.8e-16 56.4 8.2 4 6 9.3e-06 0.019 14.2 0.0 1 27 318 344 318 345 0.95 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|542|gw1.3.102.1 - 437 8.8e-16 56.4 8.2 5 6 0.0027 5.3 6.5 0.1 7 23 361 377 357 377 0.93 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|542|gw1.3.102.1 - 437 8.8e-16 56.4 8.2 6 6 0.018 36 3.8 0.1 17 31 411 425 398 427 0.84 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|542|gw1.3.102.1 - 437 4.5e-06 26.2 7.1 1 6 0.013 25 5.3 0.0 7 22 6 21 2 21 0.84 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|542|gw1.3.102.1 - 437 4.5e-06 26.2 7.1 2 6 6 1.2e+04 -4.3 0.0 18 23 39 44 37 47 0.60 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|542|gw1.3.102.1 - 437 4.5e-06 26.2 7.1 3 6 0.54 1.1e+03 0.3 0.0 1 20 278 297 278 301 0.75 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|542|gw1.3.102.1 - 437 4.5e-06 26.2 7.1 4 6 0.00024 0.47 10.7 0.0 1 24 318 341 318 343 0.91 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|542|gw1.3.102.1 - 437 4.5e-06 26.2 7.1 5 6 0.0017 3.4 8.0 0.1 2 22 356 376 355 377 0.91 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|542|gw1.3.102.1 - 437 4.5e-06 26.2 7.1 6 6 1.9 3.8e+03 -1.4 0.2 17 26 418 427 402 427 0.80 Tetratricopeptide repeat +Rapsyn_N PF10579.2 80 jgi|Monbr1|542|gw1.3.102.1 - 437 0.0017 17.7 0.1 1 2 0.34 6.7e+02 -0.2 0.0 65 80 301 315 277 315 0.70 Rapsyn N-terminal myristoylation and linker region +Rapsyn_N PF10579.2 80 jgi|Monbr1|542|gw1.3.102.1 - 437 0.0017 17.7 0.1 2 2 9.8e-06 0.019 14.4 0.1 21 78 333 390 326 392 0.92 Rapsyn N-terminal myristoylation and linker region +DUF3359 PF11839.1 96 jgi|Monbr1|542|gw1.3.102.1 - 437 0.014 15.3 1.1 1 3 5.9 1.2e+04 -3.6 0.0 45 51 21 27 14 50 0.45 Protein of unknown function (DUF3359) +DUF3359 PF11839.1 96 jgi|Monbr1|542|gw1.3.102.1 - 437 0.014 15.3 1.1 2 3 0.88 1.7e+03 -1.0 0.1 64 82 279 297 243 311 0.49 Protein of unknown function (DUF3359) +DUF3359 PF11839.1 96 jgi|Monbr1|542|gw1.3.102.1 - 437 0.014 15.3 1.1 3 3 7.3e-06 0.014 15.3 0.8 14 84 316 390 310 396 0.79 Protein of unknown function (DUF3359) +Thioesterase PF00975.13 229 jgi|Monbr1|542|gw1.3.102.1 - 437 0.081 12.8 2.0 1 2 2.1 4.2e+03 -2.6 0.0 110 139 138 171 110 228 0.55 Thioesterase domain +Thioesterase PF00975.13 229 jgi|Monbr1|542|gw1.3.102.1 - 437 0.081 12.8 2.0 2 2 3.4e-05 0.067 13.0 0.4 123 227 295 430 256 432 0.81 Thioesterase domain +Glyco_hydro_59 PF02057.8 669 jgi|Monbr1|566|gw1.2.121.1 - 481 1.6e-120 402.9 0.4 1 1 1.4e-123 5.4e-120 401.1 0.3 27 481 1 463 1 480 0.88 Glycosyl hydrolase family 59 +Glyco_hydro_30 PF02055.9 496 jgi|Monbr1|566|gw1.2.121.1 - 481 0.0019 16.2 0.1 1 1 6.2e-07 0.0025 15.7 0.1 155 189 88 122 30 167 0.84 O-Glycosyl hydrolase family 30 +Borealin PF10512.2 116 jgi|Monbr1|566|gw1.2.121.1 - 481 0.11 12.0 0.0 1 2 0.00013 0.52 9.9 0.0 24 97 195 268 176 272 0.83 Cell division cycle-associated protein 8 +Borealin PF10512.2 116 jgi|Monbr1|566|gw1.2.121.1 - 481 0.11 12.0 0.0 2 2 0.39 1.5e+03 -1.3 0.0 69 84 413 429 395 434 0.70 Cell division cycle-associated protein 8 +DNA_pol_A PF00476.13 383 jgi|Monbr1|624|gw1.8.75.1 - 882 1.2e-84 283.8 0.0 1 1 7e-88 1.7e-84 283.3 0.0 17 383 449 849 439 849 0.89 DNA polymerase family A +DUF3670 PF12419.1 141 jgi|Monbr1|624|gw1.8.75.1 - 882 0.015 14.4 0.0 1 1 1.5e-05 0.035 13.2 0.0 73 108 299 334 283 336 0.84 SNF2 Helicase protein +3_5_exonuc PF01612.13 174 jgi|Monbr1|624|gw1.8.75.1 - 882 0.041 13.0 0.0 1 1 3.5e-05 0.083 12.0 0.0 117 172 202 265 165 266 0.72 3'-5' exonuclease +DUF1454 PF07305.5 200 jgi|Monbr1|624|gw1.8.75.1 - 882 0.084 11.6 0.0 1 2 0.00015 0.37 9.5 0.0 125 160 666 701 635 709 0.86 Protein of unknown function (DUF1454) +DUF1454 PF07305.5 200 jgi|Monbr1|624|gw1.8.75.1 - 882 0.084 11.6 0.0 2 2 0.3 7.1e+02 -1.2 0.0 167 185 803 821 791 830 0.80 Protein of unknown function (DUF1454) +Feld-I_B PF09252.3 67 jgi|Monbr1|624|gw1.8.75.1 - 882 0.11 12.0 0.0 1 1 9.6e-05 0.23 11.0 0.0 7 46 657 696 655 702 0.89 Allergen Fel d I-B chain +FbpA PF05833.4 453 jgi|Monbr1|628|gw1.2.134.1 - 1051 1.4e-39 135.6 8.4 1 2 4.7e-43 1.4e-39 135.6 5.8 3 407 8 506 6 526 0.84 Fibronectin-binding protein A N-terminus (FbpA) +FbpA PF05833.4 453 jgi|Monbr1|628|gw1.2.134.1 - 1051 1.4e-39 135.6 8.4 2 2 2 6e+03 -5.0 2.5 385 424 857 896 843 916 0.73 Fibronectin-binding protein A N-terminus (FbpA) +DUF3441 PF11923.1 113 jgi|Monbr1|628|gw1.2.134.1 - 1051 6.5e-28 96.2 0.0 1 1 9.1e-31 2.7e-27 94.2 0.0 2 111 950 1050 949 1051 0.97 Domain of unknown function (DUF3441) +DUF814 PF05670.6 90 jgi|Monbr1|628|gw1.2.134.1 - 1051 8e-23 79.8 0.0 1 1 9.7e-26 2.9e-22 78.0 0.0 1 82 534 616 534 634 0.84 Domain of unknown function (DUF814) +Osteoregulin PF07175.4 163 jgi|Monbr1|628|gw1.2.134.1 - 1051 0.15 11.5 2.8 1 1 0.00014 0.41 10.1 2.0 50 152 786 891 769 896 0.86 Osteoregulin +DUF663 PF04950.5 297 jgi|Monbr1|635|gw1.6.50.1 - 990 3.1e-82 275.5 0.0 1 2 3.6e-85 3.1e-82 275.5 0.0 10 297 541 825 530 825 0.87 Protein of unknown function (DUF663) +DUF663 PF04950.5 297 jgi|Monbr1|635|gw1.6.50.1 - 990 3.1e-82 275.5 0.0 2 2 6.8 5.8e+03 -4.4 1.9 30 61 927 956 904 987 0.48 Protein of unknown function (DUF663) +AARP2CN PF08142.5 84 jgi|Monbr1|635|gw1.6.50.1 - 990 3.1e-27 93.6 0.0 1 1 7.6e-30 6.5e-27 92.5 0.0 1 84 175 261 175 261 0.97 AARP2CN (NUC121) domain +GTP_EFTU PF00009.20 189 jgi|Monbr1|635|gw1.6.50.1 - 990 8e-09 34.8 0.0 1 1 9.1e-10 7.8e-07 28.3 0.0 55 170 57 165 24 188 0.78 Elongation factor Tu GTP binding domain +AAA PF00004.22 130 jgi|Monbr1|635|gw1.6.50.1 - 990 0.00011 22.1 0.0 1 2 2e-05 0.017 15.0 0.0 1 52 29 87 29 100 0.63 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|635|gw1.6.50.1 - 990 0.00011 22.1 0.0 2 2 0.046 39 4.1 0.0 42 101 533 594 523 611 0.78 ATPase family associated with various cellular activities (AAA) +Miro PF08477.6 119 jgi|Monbr1|635|gw1.6.50.1 - 990 0.0015 18.6 0.0 1 1 4.6e-06 0.0039 17.3 0.0 2 82 29 99 28 116 0.78 Miro-like protein +MobB PF03205.7 137 jgi|Monbr1|635|gw1.6.50.1 - 990 0.0025 17.3 0.1 1 1 7.4e-06 0.0063 16.0 0.1 2 28 28 54 27 59 0.88 Molybdopterin guanine dinucleotide synthesis protein B +DUF265 PF03266.8 168 jgi|Monbr1|635|gw1.6.50.1 - 990 0.0069 15.7 0.3 1 1 1.7e-05 0.014 14.7 0.2 2 36 29 64 28 75 0.76 Protein of unknown function, DUF265 +PduV-EutP PF10662.2 143 jgi|Monbr1|635|gw1.6.50.1 - 990 0.025 13.7 0.0 1 1 9.9e-05 0.084 12.0 0.0 4 124 29 155 27 160 0.76 Ethanolamine utilisation - propanediol utilisation +SRPRB PF09439.3 181 jgi|Monbr1|635|gw1.6.50.1 - 990 0.035 13.0 0.0 1 1 0.00011 0.093 11.6 0.0 6 57 29 78 26 87 0.86 Signal recognition particle receptor beta subunit +RNA_helicase PF00910.15 107 jgi|Monbr1|635|gw1.6.50.1 - 990 0.093 12.6 0.0 1 1 0.0004 0.34 10.8 0.0 1 32 29 60 29 92 0.76 RNA helicase +DnaB_C PF03796.8 185 jgi|Monbr1|635|gw1.6.50.1 - 990 0.1 11.5 0.0 1 1 0.00031 0.26 10.1 0.0 13 47 20 54 12 64 0.84 DnaB-like helicase C terminal domain +NACHT PF05729.5 166 jgi|Monbr1|635|gw1.6.50.1 - 990 0.1 11.8 0.0 1 1 0.00028 0.24 10.7 0.0 2 31 28 57 27 81 0.88 NACHT domain +Arch_ATPase PF01637.11 234 jgi|Monbr1|635|gw1.6.50.1 - 990 0.14 11.5 1.1 1 2 0.00028 0.24 10.7 0.0 21 44 27 50 19 61 0.85 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|635|gw1.6.50.1 - 990 0.14 11.5 1.1 2 2 4.7 4e+03 -3.1 0.4 177 197 950 970 913 988 0.47 Archaeal ATPase +Zeta_toxin PF06414.5 201 jgi|Monbr1|635|gw1.6.50.1 - 990 0.21 10.3 0.0 1 2 0.00025 0.21 10.3 0.0 12 41 22 51 12 60 0.80 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|635|gw1.6.50.1 - 990 0.21 10.3 0.0 2 2 8.6 7.3e+03 -4.5 0.5 153 184 917 948 898 964 0.60 Zeta toxin +UPF1_Zn_bind PF09416.3 152 jgi|Monbr1|650|gw1.2.137.1 - 856 2.9e-72 240.9 5.9 1 2 2.1e-74 1.5e-71 238.6 1.6 1 152 16 167 16 167 0.99 RNA helicase (UPF2 interacting domain) +UPF1_Zn_bind PF09416.3 152 jgi|Monbr1|650|gw1.2.137.1 - 856 2.9e-72 240.9 5.9 2 2 0.058 41 3.4 0.1 31 61 398 429 394 454 0.77 RNA helicase (UPF2 interacting domain) +ResIII PF04851.8 184 jgi|Monbr1|650|gw1.2.137.1 - 856 6.6e-10 38.7 0.0 1 1 1.8e-12 1.3e-09 37.8 0.0 3 155 369 537 367 560 0.70 Type III restriction enzyme, res subunit +DUF699 PF05127.7 174 jgi|Monbr1|650|gw1.2.137.1 - 856 4.6e-05 22.7 0.0 1 1 1.5e-07 0.0001 21.6 0.0 2 57 389 445 388 539 0.80 Putative ATPase (DUF699) +DEAD PF00270.22 167 jgi|Monbr1|650|gw1.2.137.1 - 856 9.5e-05 21.6 0.2 1 1 2.8e-07 0.00019 20.6 0.1 3 104 373 472 371 542 0.80 DEAD/DEAH box helicase +DUF2075 PF09848.2 352 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00012 20.8 1.5 1 3 9e-07 0.00063 18.5 0.0 3 55 386 437 384 544 0.67 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00012 20.8 1.5 2 3 1.4 9.5e+02 -1.9 0.0 273 291 720 738 697 747 0.74 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00012 20.8 1.5 3 3 0.46 3.3e+02 -0.3 0.0 334 349 757 772 752 774 0.91 Uncharacterized conserved protein (DUF2075) +SRP54 PF00448.15 196 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00038 19.6 0.0 1 1 9.2e-07 0.00064 18.9 0.0 5 66 388 450 385 523 0.82 SRP54-type protein, GTPase domain +Viral_helicase1 PF01443.11 226 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00048 19.4 0.1 1 3 0.9 6.3e+02 -0.6 0.0 2 21 388 407 387 455 0.70 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00048 19.4 0.1 2 3 0.0099 6.9 5.8 0.0 54 97 523 566 475 589 0.78 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|650|gw1.2.137.1 - 856 0.00048 19.4 0.1 3 3 0.00058 0.41 9.8 0.0 159 225 701 772 650 773 0.64 Viral (Superfamily 1) RNA helicase +PhoH PF02562.9 205 jgi|Monbr1|650|gw1.2.137.1 - 856 0.0016 17.4 0.0 1 2 9.8e-06 0.0069 15.3 0.0 6 57 371 422 367 440 0.84 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|650|gw1.2.137.1 - 856 0.0016 17.4 0.0 2 2 1.6 1.1e+03 -1.7 0.0 115 155 526 562 518 581 0.64 PhoH-like protein +UvrD-helicase PF00580.14 533 jgi|Monbr1|650|gw1.2.137.1 - 856 0.0025 16.2 0.0 1 2 2.1e-05 0.014 13.7 0.0 1 68 370 443 370 513 0.77 UvrD/REP helicase +UvrD-helicase PF00580.14 533 jgi|Monbr1|650|gw1.2.137.1 - 856 0.0025 16.2 0.0 2 2 0.31 2.1e+02 -0.1 0.0 241 280 527 564 517 565 0.78 UvrD/REP helicase +Ribosomal_S13_N PF08069.5 60 jgi|Monbr1|650|gw1.2.137.1 - 856 0.016 14.7 0.0 1 1 4.9e-05 0.034 13.6 0.0 28 53 667 692 657 693 0.90 Ribosomal S13/S15 N-terminal domain +KaiC PF06745.6 226 jgi|Monbr1|650|gw1.2.137.1 - 856 0.018 13.8 0.0 1 2 0.00012 0.082 11.6 0.0 17 74 382 440 363 501 0.81 KaiC +KaiC PF06745.6 226 jgi|Monbr1|650|gw1.2.137.1 - 856 0.018 13.8 0.0 2 2 0.92 6.5e+02 -1.1 0.0 36 96 676 735 675 758 0.84 KaiC +SNF2_N PF00176.16 297 jgi|Monbr1|650|gw1.2.137.1 - 856 0.03 13.1 0.0 1 1 8.7e-05 0.061 12.1 0.0 26 87 394 455 391 538 0.76 SNF2 family N-terminal domain +IstB PF01695.10 178 jgi|Monbr1|650|gw1.2.137.1 - 856 0.037 13.1 0.0 1 1 0.00015 0.11 11.6 0.0 45 77 382 414 355 437 0.78 IstB-like ATP binding protein +AAA_5 PF07728.7 139 jgi|Monbr1|650|gw1.2.137.1 - 856 0.092 12.1 0.0 1 1 0.00037 0.26 10.7 0.0 3 46 388 434 387 451 0.83 AAA domain (dynein-related subfamily) +GSPII_E PF00437.13 282 jgi|Monbr1|650|gw1.2.137.1 - 856 0.098 11.2 0.0 1 1 0.00024 0.17 10.4 0.0 125 167 376 413 328 434 0.77 Type II/IV secretion system protein +AAA PF00004.22 130 jgi|Monbr1|650|gw1.2.137.1 - 856 0.11 12.4 0.0 1 1 0.00038 0.27 11.1 0.0 2 22 388 408 387 459 0.67 ATPase family associated with various cellular activities (AAA) +NACHT PF05729.5 166 jgi|Monbr1|650|gw1.2.137.1 - 856 0.12 11.6 0.0 1 1 0.00036 0.25 10.6 0.0 3 123 387 511 385 538 0.64 NACHT domain +SNF2_N PF00176.16 297 jgi|Monbr1|689|gw1.3.143.1 - 751 2.4e-85 285.9 2.9 1 1 3.7e-88 5.5e-85 284.7 2.0 1 296 165 446 165 447 0.92 SNF2 family N-terminal domain +Helicase_C PF00271.24 78 jgi|Monbr1|689|gw1.3.143.1 - 751 2.3e-16 59.1 0.1 1 2 0.23 3.4e+02 0.8 0.0 6 40 235 271 231 274 0.76 Helicase conserved C-terminal domain +Helicase_C PF00271.24 78 jgi|Monbr1|689|gw1.3.143.1 - 751 2.3e-16 59.1 0.1 2 2 3e-18 4.5e-15 54.9 0.0 3 78 506 584 504 584 0.95 Helicase conserved C-terminal domain +Chromo PF00385.17 55 jgi|Monbr1|689|gw1.3.143.1 - 751 1.7e-15 56.0 9.9 1 3 4.6e-06 0.0068 15.7 0.1 20 43 5 28 2 36 0.92 'chromo' (CHRromatin Organisation MOdifier) domain +Chromo PF00385.17 55 jgi|Monbr1|689|gw1.3.143.1 - 751 1.7e-15 56.0 9.9 2 3 3.9e-14 5.9e-11 41.5 0.7 2 53 78 126 77 128 0.92 'chromo' (CHRromatin Organisation MOdifier) domain +Chromo PF00385.17 55 jgi|Monbr1|689|gw1.3.143.1 - 751 1.7e-15 56.0 9.9 3 3 0.046 68 2.9 0.1 2 22 393 410 392 411 0.88 'chromo' (CHRromatin Organisation MOdifier) domain +DEAD PF00270.22 167 jgi|Monbr1|689|gw1.3.143.1 - 751 8.4e-09 34.7 0.0 1 1 1.2e-11 1.8e-08 33.7 0.0 12 162 178 327 163 332 0.83 DEAD/DEAH box helicase +ResIII PF04851.8 184 jgi|Monbr1|689|gw1.3.143.1 - 751 2e-07 30.7 0.0 1 2 8.7e-10 1.3e-06 28.0 0.0 2 182 160 324 159 326 0.87 Type III restriction enzyme, res subunit +ResIII PF04851.8 184 jgi|Monbr1|689|gw1.3.143.1 - 751 2e-07 30.7 0.0 2 2 0.74 1.1e+03 -1.1 0.0 35 56 468 492 462 538 0.78 Type III restriction enzyme, res subunit +HDA2-3 PF11496.1 296 jgi|Monbr1|689|gw1.3.143.1 - 751 4.2e-07 28.7 0.6 1 1 7.7e-10 1.1e-06 27.3 0.4 86 264 460 618 397 653 0.79 Class II histone deacetylase complex subunits 2 and 3 +OTCace PF00185.17 158 jgi|Monbr1|689|gw1.3.143.1 - 751 0.11 12.0 0.4 1 2 0.00029 0.43 10.1 0.0 14 91 221 296 216 319 0.77 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain +OTCace PF00185.17 158 jgi|Monbr1|689|gw1.3.143.1 - 751 0.11 12.0 0.4 2 2 1.8 2.8e+03 -2.3 0.0 88 116 586 614 556 625 0.66 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain +Borrelia_lipo_1 PF05714.4 207 jgi|Monbr1|689|gw1.3.143.1 - 751 0.15 10.8 2.8 1 2 0.00077 1.1 8.0 0.5 120 167 20 67 15 90 0.85 Borrelia burgdorferi virulent strain associated lipoprotein +Borrelia_lipo_1 PF05714.4 207 jgi|Monbr1|689|gw1.3.143.1 - 751 0.15 10.8 2.8 2 2 0.042 63 2.3 0.0 63 101 407 445 398 483 0.81 Borrelia burgdorferi virulent strain associated lipoprotein +SNF2_N PF00176.16 297 jgi|Monbr1|717|gw1.2.155.1 - 649 6.1e-62 209.1 0.0 1 1 4.9e-65 8.3e-62 208.6 0.0 1 297 48 382 48 382 0.90 SNF2 family N-terminal domain +Helicase_C PF00271.24 78 jgi|Monbr1|717|gw1.2.155.1 - 649 3.6e-13 48.8 0.0 1 1 4.7e-16 8e-13 47.7 0.0 3 78 518 595 516 595 0.97 Helicase conserved C-terminal domain +DEAD PF00270.22 167 jgi|Monbr1|717|gw1.2.155.1 - 649 9.3e-08 31.4 0.0 1 1 1.5e-10 2.6e-07 29.9 0.0 19 142 69 202 49 218 0.79 DEAD/DEAH box helicase +ResIII PF04851.8 184 jgi|Monbr1|717|gw1.2.155.1 - 649 5e-05 22.8 0.0 1 2 8.6e-08 0.00015 21.3 0.0 4 182 45 218 42 220 0.73 Type III restriction enzyme, res subunit +ResIII PF04851.8 184 jgi|Monbr1|717|gw1.2.155.1 - 649 5e-05 22.8 0.0 2 2 4 6.9e+03 -3.7 0.0 61 76 342 357 341 364 0.79 Type III restriction enzyme, res subunit +zf-C3HC4 PF00097.18 42 jgi|Monbr1|717|gw1.2.155.1 - 649 0.00045 19.7 2.2 1 3 3.9 6.6e+03 -3.2 5.1 19 42 239 263 231 263 0.80 Zinc finger, C3HC4 type (RING finger) +zf-C3HC4 PF00097.18 42 jgi|Monbr1|717|gw1.2.155.1 - 649 0.00045 19.7 2.2 2 3 7 1.2e+04 -8.6 7.3 13 23 258 272 243 273 0.54 Zinc finger, C3HC4 type (RING finger) +zf-C3HC4 PF00097.18 42 jgi|Monbr1|717|gw1.2.155.1 - 649 0.00045 19.7 2.2 3 3 2.7e-07 0.00045 19.7 1.6 1 42 397 439 397 439 0.89 Zinc finger, C3HC4 type (RING finger) +zf-Nse PF11789.1 57 jgi|Monbr1|717|gw1.2.155.1 - 649 0.017 14.3 2.8 1 1 3.6e-05 0.061 12.5 1.9 9 56 392 439 387 440 0.82 Zinc-finger of the MIZ type in Nse subunit +DNA_RNApol_7kD PF03604.6 32 jgi|Monbr1|717|gw1.2.155.1 - 649 1.9 7.7 6.0 1 1 0.0065 11 5.2 4.1 1 28 241 268 241 269 0.67 DNA directed RNA polymerase, 7 kDa subunit +DUF1205 PF06722.5 97 jgi|Monbr1|776|gw1.7.65.1 - 501 0.024 14.5 0.0 1 2 0.46 5.5e+03 -2.7 0.0 41 68 127 153 115 163 0.76 Protein of unknown function (DUF1205) +DUF1205 PF06722.5 97 jgi|Monbr1|776|gw1.7.65.1 - 501 0.024 14.5 0.0 2 2 1.2e-05 0.15 12.0 0.0 38 79 293 334 283 350 0.86 Protein of unknown function (DUF1205) +Thioredoxin PF00085.13 104 jgi|Monbr1|784|gw1.5.103.1 - 436 1.1e-63 211.1 0.0 1 4 3.7e-36 5.5e-33 112.4 0.0 2 103 2 102 1 103 0.96 Thioredoxin +Thioredoxin PF00085.13 104 jgi|Monbr1|784|gw1.5.103.1 - 436 1.1e-63 211.1 0.0 2 4 0.15 2.2e+02 1.2 0.0 60 103 159 202 145 203 0.83 Thioredoxin +Thioredoxin PF00085.13 104 jgi|Monbr1|784|gw1.5.103.1 - 436 1.1e-63 211.1 0.0 3 4 0.013 19 4.6 0.0 40 103 240 306 235 307 0.83 Thioredoxin +Thioredoxin PF00085.13 104 jgi|Monbr1|784|gw1.5.103.1 - 436 1.1e-63 211.1 0.0 4 4 2e-28 2.9e-25 87.6 0.0 4 103 331 433 328 434 0.94 Thioredoxin +AhpC-TSA PF00578.14 124 jgi|Monbr1|784|gw1.5.103.1 - 436 1.1e-08 34.4 0.0 1 2 3.3e-07 0.00049 19.4 0.0 24 67 15 58 4 81 0.85 AhpC/TSA family +AhpC-TSA PF00578.14 124 jgi|Monbr1|784|gw1.5.103.1 - 436 1.1e-08 34.4 0.0 2 2 7.2e-05 0.11 11.9 0.0 26 64 346 383 327 396 0.83 AhpC/TSA family +Redoxin PF08534.3 146 jgi|Monbr1|784|gw1.5.103.1 - 436 1.8e-08 33.7 0.8 1 3 0.00012 0.17 11.0 0.0 27 67 15 55 4 71 0.77 Redoxin +Redoxin PF08534.3 146 jgi|Monbr1|784|gw1.5.103.1 - 436 1.8e-08 33.7 0.8 2 3 0.049 73 2.5 0.0 33 96 96 164 74 173 0.75 Redoxin +Redoxin PF08534.3 146 jgi|Monbr1|784|gw1.5.103.1 - 436 1.8e-08 33.7 0.8 3 3 2.5e-06 0.0038 16.4 0.0 27 67 344 383 319 396 0.89 Redoxin +Calsequestrin PF01216.10 383 jgi|Monbr1|784|gw1.5.103.1 - 436 5.3e-08 31.7 0.1 1 1 4.8e-11 7.1e-08 31.2 0.1 82 244 42 201 3 241 0.85 Calsequestrin +ERp29_N PF07912.6 126 jgi|Monbr1|784|gw1.5.103.1 - 436 8.9e-07 28.5 0.0 1 2 0.00022 0.33 10.5 0.0 7 97 3 87 1 105 0.73 ERp29, N-terminal domain +ERp29_N PF07912.6 126 jgi|Monbr1|784|gw1.5.103.1 - 436 8.9e-07 28.5 0.0 2 2 7e-06 0.01 15.4 0.0 72 119 262 308 256 312 0.84 ERp29, N-terminal domain +Glutaredoxin PF00462.17 60 jgi|Monbr1|784|gw1.5.103.1 - 436 0.022 14.4 0.2 1 2 0.072 1.1e+02 2.6 0.1 6 15 26 35 19 77 0.78 Glutaredoxin +Glutaredoxin PF00462.17 60 jgi|Monbr1|784|gw1.5.103.1 - 436 0.022 14.4 0.2 2 2 0.00077 1.2 8.9 0.0 5 27 354 375 345 405 0.67 Glutaredoxin +DSBA PF01323.13 193 jgi|Monbr1|784|gw1.5.103.1 - 436 0.28 10.3 1.5 1 4 0.52 7.7e+02 -0.9 0.0 2 26 21 45 20 53 0.79 DSBA-like thioredoxin domain +DSBA PF01323.13 193 jgi|Monbr1|784|gw1.5.103.1 - 436 0.28 10.3 1.5 2 4 0.074 1.1e+02 1.9 0.0 156 190 61 98 40 101 0.75 DSBA-like thioredoxin domain +DSBA PF01323.13 193 jgi|Monbr1|784|gw1.5.103.1 - 436 0.28 10.3 1.5 3 4 0.14 2.1e+02 1.0 0.1 133 176 136 179 127 200 0.71 DSBA-like thioredoxin domain +DSBA PF01323.13 193 jgi|Monbr1|784|gw1.5.103.1 - 436 0.28 10.3 1.5 4 4 0.026 38 3.4 0.0 9 29 356 376 349 402 0.85 DSBA-like thioredoxin domain +Mu-like_Com PF10122.2 51 jgi|Monbr1|784|gw1.5.103.1 - 436 0.65 8.7 2.6 1 2 0.032 48 2.7 0.1 7 13 29 35 28 46 0.82 Mu-like prophage protein Com +Mu-like_Com PF10122.2 51 jgi|Monbr1|784|gw1.5.103.1 - 436 0.65 8.7 2.6 2 2 0.0045 6.8 5.5 0.2 7 13 357 363 356 372 0.87 Mu-like prophage protein Com +MatE PF01554.11 162 jgi|Monbr1|790|gw1.5.105.1 - 446 9.5e-54 181.0 30.6 1 4 3.5e-29 4.2e-25 87.9 7.6 1 161 14 174 14 175 0.98 MatE +MatE PF01554.11 162 jgi|Monbr1|790|gw1.5.105.1 - 446 9.5e-54 181.0 30.6 2 4 0.43 5.1e+03 -3.4 0.3 43 58 184 199 182 202 0.75 MatE +MatE PF01554.11 162 jgi|Monbr1|790|gw1.5.105.1 - 446 9.5e-54 181.0 30.6 3 4 4.4e-35 5.3e-31 107.1 8.1 1 162 236 397 236 397 0.98 MatE +MatE PF01554.11 162 jgi|Monbr1|790|gw1.5.105.1 - 446 9.5e-54 181.0 30.6 4 4 0.23 2.7e+03 -2.5 0.1 36 57 408 429 402 442 0.58 MatE +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 1 9 0.0002 0.33 10.5 0.5 28 41 3 16 1 16 0.88 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 2 9 1.4e-13 2.4e-10 39.5 0.2 2 40 19 57 18 58 0.94 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 3 9 5.5e-07 0.00094 18.6 0.1 2 41 61 101 60 101 0.94 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 4 9 1e-07 0.00018 20.9 0.0 14 41 116 143 102 143 0.76 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 5 9 1.9e-11 3.2e-08 32.7 0.0 3 41 147 185 145 185 0.91 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 6 9 1.6e-13 2.8e-10 39.3 0.6 1 40 187 226 187 227 0.97 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 7 9 0.027 45 3.7 0.0 4 38 232 266 232 269 0.90 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 8 9 2.8e-06 0.0048 16.3 0.0 2 39 273 310 272 312 0.87 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|793|gw1.2.178.1 - 365 4.7e-53 174.9 22.1 9 9 0.16 2.7e+02 1.2 0.0 2 28 322 348 321 356 0.73 Armadillo/beta-catenin-like repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 1 7 0.74 1.3e+03 -0.3 0.0 20 28 7 15 5 20 0.83 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 2 7 0.00036 0.62 10.0 0.0 2 28 31 57 30 58 0.93 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 3 7 0.23 3.9e+02 1.2 0.0 19 30 91 102 89 103 0.88 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 4 7 1.3 2.2e+03 -1.1 0.0 11 29 125 143 117 144 0.76 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 5 7 0.00043 0.73 9.7 0.0 3 29 159 185 157 187 0.91 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 6 7 0.16 2.6e+02 1.8 0.1 1 28 199 226 199 226 0.79 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|793|gw1.2.178.1 - 365 8e-08 31.4 7.3 7 7 0.016 28 4.8 0.1 2 29 285 312 284 313 0.91 HEAT repeat +DUF634 PF04826.6 254 jgi|Monbr1|793|gw1.2.178.1 - 365 2e-06 26.8 0.0 1 3 0.00084 1.4 7.6 0.0 56 114 31 92 14 99 0.76 Protein of unknown function (DUF634) +DUF634 PF04826.6 254 jgi|Monbr1|793|gw1.2.178.1 - 365 2e-06 26.8 0.0 2 3 6.4e-06 0.011 14.5 0.0 17 189 118 297 111 323 0.79 Protein of unknown function (DUF634) +DUF634 PF04826.6 254 jgi|Monbr1|793|gw1.2.178.1 - 365 2e-06 26.8 0.0 3 3 0.22 3.7e+02 -0.3 0.0 47 75 325 353 308 359 0.80 Protein of unknown function (DUF634) +Adaptin_N PF01602.13 536 jgi|Monbr1|793|gw1.2.178.1 - 365 2.4e-05 22.5 0.1 1 3 0.019 33 2.2 0.0 389 454 31 99 8 143 0.76 Adaptin N terminal region +Adaptin_N PF01602.13 536 jgi|Monbr1|793|gw1.2.178.1 - 365 2.4e-05 22.5 0.1 2 3 2.2e-06 0.0037 15.3 0.0 88 138 165 222 153 267 0.87 Adaptin N terminal region +Adaptin_N PF01602.13 536 jgi|Monbr1|793|gw1.2.178.1 - 365 2.4e-05 22.5 0.1 3 3 0.051 87 0.8 0.0 275 320 281 329 272 332 0.75 Adaptin N terminal region +Atx10homo_assoc PF09759.2 102 jgi|Monbr1|793|gw1.2.178.1 - 365 0.003 16.9 1.8 1 4 0.00029 0.5 9.8 0.0 9 71 10 70 5 72 0.87 Spinocerebellar ataxia type 10 protein domain +Atx10homo_assoc PF09759.2 102 jgi|Monbr1|793|gw1.2.178.1 - 365 0.003 16.9 1.8 2 4 0.00018 0.31 10.4 0.0 3 59 46 101 44 105 0.90 Spinocerebellar ataxia type 10 protein domain +Atx10homo_assoc PF09759.2 102 jgi|Monbr1|793|gw1.2.178.1 - 365 0.003 16.9 1.8 3 4 0.097 1.7e+02 1.7 0.1 8 61 178 229 174 239 0.68 Spinocerebellar ataxia type 10 protein domain +Atx10homo_assoc PF09759.2 102 jgi|Monbr1|793|gw1.2.178.1 - 365 0.003 16.9 1.8 4 4 2.7 4.7e+03 -3.0 0.0 37 59 290 312 287 318 0.76 Spinocerebellar ataxia type 10 protein domain +HEAT_PBS PF03130.9 27 jgi|Monbr1|793|gw1.2.178.1 - 365 0.0055 16.7 6.4 1 6 0.056 96 3.6 0.1 4 26 6 39 3 40 0.70 PBS lyase HEAT-like repeat +HEAT_PBS PF03130.9 27 jgi|Monbr1|793|gw1.2.178.1 - 365 0.0055 16.7 6.4 2 6 0.1 1.8e+02 2.7 0.0 2 14 46 58 45 69 0.83 PBS lyase HEAT-like repeat +HEAT_PBS PF03130.9 27 jgi|Monbr1|793|gw1.2.178.1 - 365 0.0055 16.7 6.4 3 6 0.64 1.1e+03 0.3 0.0 5 22 92 120 91 123 0.73 PBS lyase HEAT-like repeat +HEAT_PBS PF03130.9 27 jgi|Monbr1|793|gw1.2.178.1 - 365 0.0055 16.7 6.4 4 6 6 1e+04 -2.7 0.0 7 21 136 153 134 156 0.67 PBS lyase HEAT-like repeat +HEAT_PBS PF03130.9 27 jgi|Monbr1|793|gw1.2.178.1 - 365 0.0055 16.7 6.4 5 6 0.014 23 5.5 0.0 5 26 176 208 176 209 0.91 PBS lyase HEAT-like repeat +HEAT_PBS PF03130.9 27 jgi|Monbr1|793|gw1.2.178.1 - 365 0.0055 16.7 6.4 6 6 0.25 4.2e+02 1.6 0.0 9 26 276 293 257 294 0.73 PBS lyase HEAT-like repeat +Proteasom_PSMB PF10508.2 505 jgi|Monbr1|793|gw1.2.178.1 - 365 0.011 13.6 0.8 1 3 0.0053 9 4.0 0.0 102 154 12 64 2 82 0.85 Proteasome non-ATPase 26S subunit +Proteasom_PSMB PF10508.2 505 jgi|Monbr1|793|gw1.2.178.1 - 365 0.011 13.6 0.8 2 3 0.0043 7.4 4.3 0.0 80 144 201 265 188 272 0.86 Proteasome non-ATPase 26S subunit +Proteasom_PSMB PF10508.2 505 jgi|Monbr1|793|gw1.2.178.1 - 365 0.011 13.6 0.8 3 3 0.059 1e+02 0.5 0.0 295 315 288 308 276 315 0.88 Proteasome non-ATPase 26S subunit +MFS_1 PF07690.9 353 jgi|Monbr1|813|gw1.4.138.1 - 384 7e-08 31.2 22.2 1 1 1.7e-11 1e-07 30.7 15.4 1 350 8 377 8 378 0.77 Major Facilitator Superfamily +DUF2162 PF09930.2 224 jgi|Monbr1|813|gw1.4.138.1 - 384 0.059 12.1 0.0 1 3 0.21 1.3e+03 -2.0 0.0 70 86 77 93 37 125 0.55 Predicted transporter (DUF2162) +DUF2162 PF09930.2 224 jgi|Monbr1|813|gw1.4.138.1 - 384 0.059 12.1 0.0 2 3 9.9e-06 0.059 12.1 0.0 124 182 141 203 126 210 0.76 Predicted transporter (DUF2162) +DUF2162 PF09930.2 224 jgi|Monbr1|813|gw1.4.138.1 - 384 0.059 12.1 0.0 3 3 0.37 2.2e+03 -2.8 0.2 131 167 329 365 310 371 0.49 Predicted transporter (DUF2162) +Reo_sigmaC PF04582.5 326 jgi|Monbr1|823|gw1.7.70.1 - 519 0.0051 15.7 27.4 1 4 1.6e-05 0.062 12.1 3.0 39 159 48 168 36 179 0.89 Reovirus sigma C capsid protein +Reo_sigmaC PF04582.5 326 jgi|Monbr1|823|gw1.7.70.1 - 519 0.0051 15.7 27.4 2 4 0.00023 0.93 8.2 0.1 46 113 195 262 186 281 0.82 Reovirus sigma C capsid protein +Reo_sigmaC PF04582.5 326 jgi|Monbr1|823|gw1.7.70.1 - 519 0.0051 15.7 27.4 3 4 0.0051 20 3.8 1.8 35 131 310 413 292 418 0.58 Reovirus sigma C capsid protein +Reo_sigmaC PF04582.5 326 jgi|Monbr1|823|gw1.7.70.1 - 519 0.0051 15.7 27.4 4 4 0.0027 11 4.8 0.8 50 137 444 510 407 517 0.42 Reovirus sigma C capsid protein +IncA PF04156.7 191 jgi|Monbr1|823|gw1.7.70.1 - 519 0.013 14.8 116.0 1 5 0.0057 22 4.2 16.8 66 181 45 161 26 164 0.71 IncA protein +IncA PF04156.7 191 jgi|Monbr1|823|gw1.7.70.1 - 519 0.013 14.8 116.0 2 5 0.00095 3.8 6.7 17.9 67 188 107 214 104 214 0.90 IncA protein +IncA PF04156.7 191 jgi|Monbr1|823|gw1.7.70.1 - 519 0.013 14.8 116.0 3 5 0.0036 14 4.8 23.6 66 185 176 316 164 317 0.72 IncA protein +IncA PF04156.7 191 jgi|Monbr1|823|gw1.7.70.1 - 519 0.013 14.8 116.0 4 5 0.76 3e+03 -2.8 20.3 92 181 279 368 275 423 0.61 IncA protein +IncA PF04156.7 191 jgi|Monbr1|823|gw1.7.70.1 - 519 0.013 14.8 116.0 5 5 0.0022 8.7 5.5 20.3 76 169 412 517 369 519 0.86 IncA protein +DUF827 PF05701.4 487 jgi|Monbr1|823|gw1.7.70.1 - 519 1.2 7.3 114.8 1 3 0.0033 13 3.9 20.2 291 440 16 161 10 165 0.83 Plant protein of unknown function (DUF827) +DUF827 PF05701.4 487 jgi|Monbr1|823|gw1.7.70.1 - 519 1.2 7.3 114.8 2 3 1.4 5.4e+03 -4.8 31.9 187 395 152 352 134 361 0.75 Plant protein of unknown function (DUF827) +DUF827 PF05701.4 487 jgi|Monbr1|823|gw1.7.70.1 - 519 1.2 7.3 114.8 3 3 2.5e-06 0.01 14.2 22.8 73 249 354 518 351 519 0.85 Plant protein of unknown function (DUF827) +Sulfatase PF00884.16 379 jgi|Monbr1|849|gw1.5.117.1 - 486 9.9e-51 172.6 1.8 1 1 2.9e-54 1.2e-50 172.3 1.3 2 374 10 452 9 457 0.89 Sulfatase +Phosphodiest PF01663.15 364 jgi|Monbr1|849|gw1.5.117.1 - 486 1.2e-05 24.5 0.9 1 1 2.5e-08 9.8e-05 21.5 0.6 200 247 251 306 36 322 0.80 Type I phosphodiesterase / nucleotide pyrophosphatase +DUF229 PF02995.10 499 jgi|Monbr1|849|gw1.5.117.1 - 486 0.00047 18.4 0.0 1 1 1.7e-07 0.00069 17.8 0.0 310 353 267 310 237 341 0.79 Protein of unknown function (DUF229) +Sulfatase PF00884.16 379 jgi|Monbr1|891|gw1.5.124.1 - 328 4.3e-58 196.8 0.2 1 1 8.1e-62 4.8e-58 196.6 0.1 5 306 4 328 1 328 0.94 Sulfatase +Phosphodiest PF01663.15 364 jgi|Monbr1|891|gw1.5.124.1 - 328 0.0013 17.7 0.0 1 2 0.073 4.4e+02 -0.4 0.0 21 59 24 61 12 63 0.71 Type I phosphodiesterase / nucleotide pyrophosphatase +Phosphodiest PF01663.15 364 jgi|Monbr1|891|gw1.5.124.1 - 328 0.0013 17.7 0.0 2 2 1.4e-06 0.0084 15.1 0.0 210 244 228 262 190 276 0.88 Type I phosphodiesterase / nucleotide pyrophosphatase +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 1 14 7.5e-06 0.045 13.4 0.1 1 21 12 33 12 34 0.92 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 2 14 0.00032 1.9 8.5 0.1 1 19 36 54 36 57 0.86 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 3 14 0.00029 1.7 8.6 0.1 1 18 60 77 60 81 0.87 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 4 14 0.0002 1.2 9.1 0.1 1 19 84 103 84 105 0.91 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 5 14 0.00081 4.8 7.2 0.0 2 21 109 129 108 130 0.94 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 6 14 0.0074 44 4.3 0.3 2 22 133 154 133 154 0.90 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 7 14 0.00019 1.1 9.2 0.0 1 19 156 175 156 178 0.89 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 8 14 0.00064 3.8 7.6 0.0 2 21 181 201 180 202 0.89 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 9 14 0.0018 11 6.2 0.0 1 22 204 226 204 226 0.85 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 10 14 1.6e-05 0.098 12.4 0.0 1 22 228 250 228 250 0.93 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 11 14 0.0098 59 3.9 0.1 1 22 252 274 252 274 0.78 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 12 14 1.4e-05 0.082 12.6 0.0 1 19 276 295 276 297 0.89 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 13 14 0.0086 51 4.1 0.0 1 19 300 319 300 322 0.85 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|898|gw1.2.200.1 - 333 3e-28 93.1 34.0 14 14 1.7 1e+04 -2.9 0.0 1 8 324 331 324 332 0.81 Leucine Rich Repeat +Aldolase PF01081.12 196 jgi|Monbr1|898|gw1.2.200.1 - 333 0.064 12.1 0.0 1 1 1.7e-05 0.099 11.4 0.0 102 168 264 330 252 333 0.90 KDPG and KHG aldolase +IGPS PF00218.14 255 jgi|Monbr1|903|gw1.2.202.1 - 499 4.2e-74 248.5 0.6 1 3 0.00018 0.35 9.5 0.1 1 42 3 44 3 46 0.93 Indole-3-glycerol phosphate synthase +IGPS PF00218.14 255 jgi|Monbr1|903|gw1.2.202.1 - 499 4.2e-74 248.5 0.6 2 3 2.5e-74 4.9e-71 238.4 0.0 63 255 42 243 41 243 0.96 Indole-3-glycerol phosphate synthase +IGPS PF00218.14 255 jgi|Monbr1|903|gw1.2.202.1 - 499 4.2e-74 248.5 0.6 3 3 0.79 1.6e+03 -2.4 0.0 175 208 267 300 251 337 0.60 Indole-3-glycerol phosphate synthase +PRAI PF00697.15 197 jgi|Monbr1|903|gw1.2.202.1 - 499 3.9e-43 146.9 0.0 1 2 0.00022 0.43 9.7 0.0 1 49 253 301 253 309 0.93 N-(5'phosphoribosyl)anthranilate (PRA) isomerase +PRAI PF00697.15 197 jgi|Monbr1|903|gw1.2.202.1 - 499 3.9e-43 146.9 0.0 2 2 6.6e-43 1.3e-39 135.4 0.0 37 196 329 496 297 497 0.79 N-(5'phosphoribosyl)anthranilate (PRA) isomerase +His_biosynth PF00977.14 228 jgi|Monbr1|903|gw1.2.202.1 - 499 0.011 14.6 0.1 1 3 0.0048 9.4 5.1 0.0 80 106 205 231 178 236 0.78 Histidine biosynthesis protein +His_biosynth PF00977.14 228 jgi|Monbr1|903|gw1.2.202.1 - 499 0.011 14.6 0.1 2 3 0.15 2.9e+02 0.2 0.0 80 101 256 277 233 336 0.71 Histidine biosynthesis protein +His_biosynth PF00977.14 228 jgi|Monbr1|903|gw1.2.202.1 - 499 0.011 14.6 0.1 3 3 0.0041 8.2 5.3 0.0 65 199 308 457 286 471 0.77 Histidine biosynthesis protein +QRPTase_C PF01729.12 169 jgi|Monbr1|903|gw1.2.202.1 - 499 0.033 13.4 0.0 1 3 1.6 3.1e+03 -2.8 0.0 70 104 31 65 24 89 0.68 Quinolinate phosphoribosyl transferase, C-terminal domain +QRPTase_C PF01729.12 169 jgi|Monbr1|903|gw1.2.202.1 - 499 0.033 13.4 0.0 2 3 0.00013 0.25 10.5 0.0 84 156 147 228 131 235 0.73 Quinolinate phosphoribosyl transferase, C-terminal domain +QRPTase_C PF01729.12 169 jgi|Monbr1|903|gw1.2.202.1 - 499 0.033 13.4 0.0 3 3 0.66 1.3e+03 -1.6 0.0 114 148 462 492 450 495 0.63 Quinolinate phosphoribosyl transferase, C-terminal domain +Glyco_hydro_3_C PF01915.15 211 jgi|Monbr1|903|gw1.2.202.1 - 499 0.12 11.6 0.0 1 1 9.6e-05 0.19 10.9 0.0 49 159 204 376 6 383 0.78 Glycosyl hydrolase family 3 C terminal domain +DUF305 PF03713.6 53 jgi|Monbr1|903|gw1.2.202.1 - 499 0.31 10.6 2.4 1 2 0.21 4.2e+02 0.5 0.0 19 40 25 46 23 47 0.89 Domain of unknown function (DUF305) +DUF305 PF03713.6 53 jgi|Monbr1|903|gw1.2.202.1 - 499 0.31 10.6 2.4 2 2 0.0013 2.6 7.6 0.9 17 46 294 323 290 325 0.89 Domain of unknown function (DUF305) +Nramp PF01566.11 356 jgi|Monbr1|905|gw1.2.204.1 - 396 4.9e-103 344.3 17.0 1 1 9.4e-107 5.6e-103 344.1 11.8 1 355 28 387 28 388 0.95 Natural resistance-associated macrophage protein +CitMHS PF03600.9 349 jgi|Monbr1|905|gw1.2.204.1 - 396 0.075 11.3 3.6 1 2 0.00066 3.9 5.6 0.2 122 215 137 249 124 258 0.67 Citrate transporter +CitMHS PF03600.9 349 jgi|Monbr1|905|gw1.2.204.1 - 396 0.075 11.3 3.6 2 2 0.00062 3.7 5.7 0.1 79 121 277 318 272 349 0.77 Citrate transporter +FMO-like PF00743.12 532 jgi|Monbr1|913|gw1.4.144.1 - 473 1.8e-58 197.7 0.0 1 1 2.7e-61 2e-58 197.5 0.0 3 477 1 473 1 473 0.84 Flavin-binding monooxygenase-like +Pyr_redox_2 PF07992.7 202 jgi|Monbr1|913|gw1.4.144.1 - 473 7.2e-13 48.2 0.0 1 1 6.5e-15 4.8e-12 45.5 0.0 2 160 2 258 1 288 0.68 Pyridine nucleotide-disulphide oxidoreductase +DAO PF01266.17 358 jgi|Monbr1|913|gw1.4.144.1 - 473 6.1e-07 28.3 1.4 1 2 1.9e-08 1.4e-05 23.8 0.1 3 33 3 34 1 49 0.91 FAD dependent oxidoreductase +DAO PF01266.17 358 jgi|Monbr1|913|gw1.4.144.1 - 473 6.1e-07 28.3 1.4 2 2 0.032 24 3.3 0.1 151 202 86 146 75 205 0.85 FAD dependent oxidoreductase +Amino_oxidase PF01593.17 449 jgi|Monbr1|913|gw1.4.144.1 - 473 2e-06 26.8 0.0 1 2 4.8e-08 3.6e-05 22.7 0.0 2 28 10 36 9 36 0.98 Flavin containing amine oxidoreductase +Amino_oxidase PF01593.17 449 jgi|Monbr1|913|gw1.4.144.1 - 473 2e-06 26.8 0.0 2 2 0.13 94 1.5 0.0 210 260 87 142 79 155 0.77 Flavin containing amine oxidoreductase +HI0933_like PF03486.7 409 jgi|Monbr1|913|gw1.4.144.1 - 473 7.2e-06 24.4 0.0 1 1 1.8e-08 1.3e-05 23.5 0.0 3 36 2 35 1 40 0.93 HI0933-like protein +FAD_binding_3 PF01494.12 356 jgi|Monbr1|913|gw1.4.144.1 - 473 9.8e-05 21.2 0.0 1 1 2.9e-07 0.00021 20.1 0.0 5 35 3 33 1 35 0.93 FAD binding domain +Pyr_redox PF00070.20 81 jgi|Monbr1|913|gw1.4.144.1 - 473 0.00016 21.7 0.9 1 2 9.8e-07 0.00073 19.5 0.1 2 35 2 35 1 39 0.92 Pyridine nucleotide-disulphide oxidoreductase +Pyr_redox PF00070.20 81 jgi|Monbr1|913|gw1.4.144.1 - 473 0.00016 21.7 0.9 2 2 1.6 1.2e+03 -0.4 0.0 1 27 183 209 183 218 0.84 Pyridine nucleotide-disulphide oxidoreductase +FAD_binding_2 PF00890.17 421 jgi|Monbr1|913|gw1.4.144.1 - 473 0.0011 17.5 0.0 1 1 2.6e-06 0.002 16.7 0.0 3 36 3 36 1 41 0.94 FAD binding domain +Thi4 PF01946.10 230 jgi|Monbr1|913|gw1.4.144.1 - 473 0.0036 16.1 0.2 1 2 1.1e-05 0.0081 14.9 0.0 21 54 3 36 2 40 0.94 Thi4 family +Thi4 PF01946.10 230 jgi|Monbr1|913|gw1.4.144.1 - 473 0.0036 16.1 0.2 2 2 6.7 5e+03 -4.0 0.0 120 149 411 440 407 446 0.75 Thi4 family +UDPG_MGDP_dh_N PF03721.7 185 jgi|Monbr1|913|gw1.4.144.1 - 473 0.0066 15.5 0.0 1 1 2.2e-05 0.017 14.2 0.0 2 33 1 32 1 33 0.95 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain +TrkA_N PF02254.11 116 jgi|Monbr1|913|gw1.4.144.1 - 473 0.0086 15.7 0.1 1 2 3.3e-05 0.024 14.3 0.0 2 31 3 32 2 48 0.92 TrkA-N domain +TrkA_N PF02254.11 116 jgi|Monbr1|913|gw1.4.144.1 - 473 0.0086 15.7 0.1 2 2 4.8 3.6e+03 -2.4 0.0 2 19 185 202 184 211 0.78 TrkA-N domain +DFP PF04127.8 199 jgi|Monbr1|913|gw1.4.144.1 - 473 0.01 15.1 0.0 1 1 2.6e-05 0.019 14.2 0.0 28 114 7 134 5 148 0.91 DNA / pantothenate metabolism flavoprotein +GIDA PF01134.15 392 jgi|Monbr1|913|gw1.4.144.1 - 473 0.022 13.3 0.1 1 1 4.7e-05 0.035 12.6 0.1 2 36 2 35 1 38 0.90 Glucose inhibited division protein A +Mqo PF06039.8 489 jgi|Monbr1|913|gw1.4.144.1 - 473 0.038 11.8 0.0 1 1 8.2e-05 0.061 11.1 0.0 181 238 84 140 76 155 0.77 Malate:quinone oxidoreductase (Mqo) +3HCDH_N PF02737.11 180 jgi|Monbr1|913|gw1.4.144.1 - 473 0.05 12.9 0.9 1 2 0.00049 0.36 10.1 0.0 3 32 3 32 1 35 0.92 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain +3HCDH_N PF02737.11 180 jgi|Monbr1|913|gw1.4.144.1 - 473 0.05 12.9 0.9 2 2 0.3 2.2e+02 1.0 0.1 2 21 184 203 183 213 0.88 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain +NAD_Gly3P_dh_N PF01210.16 159 jgi|Monbr1|913|gw1.4.144.1 - 473 0.11 11.9 0.1 1 2 0.0017 1.3 8.4 0.0 3 32 2 31 1 36 0.92 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus +NAD_Gly3P_dh_N PF01210.16 159 jgi|Monbr1|913|gw1.4.144.1 - 473 0.11 11.9 0.1 2 2 0.3 2.2e+02 1.1 0.0 2 33 183 214 182 221 0.86 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus +IMS PF00817.13 150 jgi|Monbr1|946|gw1.8.115.1 - 456 1.1e-44 151.5 0.1 1 2 0.12 3.6e+02 0.5 0.0 86 115 13 70 3 90 0.65 impB/mucB/samB family +IMS PF00817.13 150 jgi|Monbr1|946|gw1.8.115.1 - 456 1.1e-44 151.5 0.1 2 2 3.3e-47 9.7e-44 148.4 0.0 1 149 94 284 94 285 0.97 impB/mucB/samB family +IMS_C PF11799.1 135 jgi|Monbr1|946|gw1.8.115.1 - 456 1.7e-10 41.1 0.1 1 1 1e-13 3.1e-10 40.2 0.1 14 120 354 453 341 456 0.80 impB/mucB/samB family C-terminal +IMS_HHH PF11798.1 33 jgi|Monbr1|946|gw1.8.115.1 - 456 1.4e-06 27.6 0.0 1 1 1.2e-09 3.4e-06 26.4 0.0 3 33 300 330 298 330 0.94 IMS family HHH motif +Cdd1 PF11731.1 93 jgi|Monbr1|946|gw1.8.115.1 - 456 0.013 15.1 0.0 1 2 0.29 8.6e+02 -0.4 0.0 16 34 266 285 248 289 0.73 Pathogenicity locus +Cdd1 PF11731.1 93 jgi|Monbr1|946|gw1.8.115.1 - 456 0.013 15.1 0.0 2 2 4.1e-05 0.12 11.9 0.0 15 44 312 341 304 345 0.91 Pathogenicity locus +Peptidase_M20 PF01546.21 171 jgi|Monbr1|950|gw1.6.68.1 - 387 1.1e-23 83.3 0.0 1 1 8.7e-27 2.6e-23 82.1 0.0 1 170 16 386 16 387 0.88 Peptidase family M20/M25/M40 +M20_dimer PF07687.7 109 jgi|Monbr1|950|gw1.6.68.1 - 387 4e-13 48.7 0.1 1 1 2.3e-16 6.8e-13 48.0 0.0 2 104 140 286 139 290 0.94 Peptidase dimerisation domain +Peptidase_M28 PF04389.10 176 jgi|Monbr1|950|gw1.6.68.1 - 387 0.004 16.6 0.1 1 2 3e-06 0.0091 15.4 0.1 4 71 16 104 13 124 0.78 Peptidase family M28 +Peptidase_M28 PF04389.10 176 jgi|Monbr1|950|gw1.6.68.1 - 387 0.004 16.6 0.1 2 2 1.3 4e+03 -2.9 0.0 79 103 272 297 263 334 0.56 Peptidase family M28 +Peptidase_M42 PF05343.7 292 jgi|Monbr1|950|gw1.6.68.1 - 387 0.092 11.1 0.0 1 1 6.2e-05 0.18 10.1 0.0 128 175 46 100 31 117 0.77 M42 glutamyl aminopeptidase +PA26 PF04636.6 451 jgi|Monbr1|1017|gw1.6.77.1 - 403 2.7e-93 312.8 0.1 1 2 1.1e-55 6.8e-52 176.3 0.0 31 184 2 156 1 197 0.94 PA26 p53-induced protein (sestrin) +PA26 PF04636.6 451 jgi|Monbr1|1017|gw1.6.77.1 - 403 2.7e-93 312.8 0.1 2 2 4.5e-43 2.7e-39 134.8 0.0 313 448 268 401 258 403 0.97 PA26 p53-induced protein (sestrin) +CMD PF02627.13 85 jgi|Monbr1|1017|gw1.6.77.1 - 403 0.073 12.6 0.0 1 1 2.8e-05 0.17 11.4 0.0 5 60 23 78 19 85 0.87 Carboxymuconolactone decarboxylase family +Cellulase PF00150.11 287 jgi|Monbr1|1029|gw1.2.235.1 - 313 1e-20 73.8 0.0 1 1 7e-24 1.7e-20 73.1 0.0 17 212 38 290 26 306 0.82 Cellulase (glycosyl hydrolase family 5) +Glyco_hydro_42 PF02449.8 375 jgi|Monbr1|1029|gw1.2.235.1 - 313 0.0049 15.7 0.0 1 1 4e-06 0.0095 14.7 0.0 12 65 46 101 38 124 0.85 Beta-galactosidase +Glyco_hydro_1 PF00232.11 455 jgi|Monbr1|1029|gw1.2.235.1 - 313 0.014 13.3 0.0 1 1 9.7e-06 0.023 12.5 0.0 57 121 43 105 37 116 0.89 Glycosyl hydrolase family 1 +Glyco_hydro_2_C PF02836.10 298 jgi|Monbr1|1029|gw1.2.235.1 - 313 0.02 13.5 0.1 1 3 0.51 1.2e+03 -2.3 0.1 38 57 2 21 1 23 0.90 Glycosyl hydrolases family 2, TIM barrel domain +Glyco_hydro_2_C PF02836.10 298 jgi|Monbr1|1029|gw1.2.235.1 - 313 0.02 13.5 0.1 2 3 0.39 9.3e+02 -1.9 0.0 97 121 72 96 42 103 0.61 Glycosyl hydrolases family 2, TIM barrel domain +Glyco_hydro_2_C PF02836.10 298 jgi|Monbr1|1029|gw1.2.235.1 - 313 0.02 13.5 0.1 3 3 4.1e-05 0.097 11.2 0.0 127 164 222 259 190 266 0.85 Glycosyl hydrolases family 2, TIM barrel domain +Glyco_hydro_35 PF01301.12 319 jgi|Monbr1|1029|gw1.2.235.1 - 313 0.069 12.1 0.0 1 1 4.5e-05 0.11 11.5 0.0 32 81 52 101 43 125 0.89 Glycosyl hydrolases family 35 +Aa_trans PF01490.11 409 jgi|Monbr1|1039|gw1.5.139.1 - 389 5.3e-75 252.1 30.0 1 1 3.3e-78 6.5e-75 251.8 20.8 5 400 2 389 1 389 0.92 Transmembrane amino acid transporter protein +Trp_Tyr_perm PF03222.6 394 jgi|Monbr1|1039|gw1.5.139.1 - 389 4.6e-07 28.6 2.5 1 3 2.3e-10 4.6e-07 28.6 1.7 17 99 14 99 9 109 0.86 Tryptophan/tyrosine permease family +Trp_Tyr_perm PF03222.6 394 jgi|Monbr1|1039|gw1.5.139.1 - 389 4.6e-07 28.6 2.5 2 3 0.29 5.7e+02 -1.3 4.0 96 145 137 184 130 248 0.73 Tryptophan/tyrosine permease family +Trp_Tyr_perm PF03222.6 394 jgi|Monbr1|1039|gw1.5.139.1 - 389 4.6e-07 28.6 2.5 3 3 0.12 2.3e+02 0.0 0.2 340 361 342 364 326 369 0.86 Tryptophan/tyrosine permease family +EcsB PF05975.5 386 jgi|Monbr1|1039|gw1.5.139.1 - 389 0.0077 14.4 1.1 1 3 3.9e-06 0.0077 14.4 0.8 117 202 18 101 12 110 0.71 Bacterial ABC transporter protein EcsB +EcsB PF05975.5 386 jgi|Monbr1|1039|gw1.5.139.1 - 389 0.0077 14.4 1.1 2 3 3.6 7.1e+03 -5.2 4.5 109 128 171 190 136 261 0.53 Bacterial ABC transporter protein EcsB +EcsB PF05975.5 386 jgi|Monbr1|1039|gw1.5.139.1 - 389 0.0077 14.4 1.1 3 3 0.6 1.2e+03 -2.7 0.3 165 197 316 348 274 365 0.56 Bacterial ABC transporter protein EcsB +Spore_permease PF03845.6 320 jgi|Monbr1|1039|gw1.5.139.1 - 389 0.064 11.5 19.7 1 2 0.005 9.8 4.3 0.6 15 62 13 61 3 88 0.77 Spore germination protein +Spore_permease PF03845.6 320 jgi|Monbr1|1039|gw1.5.139.1 - 389 0.064 11.5 19.7 2 2 1.7e-05 0.033 12.5 7.1 141 267 159 288 135 299 0.82 Spore germination protein +PHO4 PF01384.13 319 jgi|Monbr1|1039|gw1.5.139.1 - 389 0.16 10.3 1.2 1 1 0.00023 0.45 8.8 0.8 21 80 234 288 224 296 0.82 Phosphate transporter family +Tmemb_40 PF10160.2 261 jgi|Monbr1|1039|gw1.5.139.1 - 389 1.6 7.6 3.8 1 2 0.00027 0.54 9.1 0.1 100 177 20 98 10 111 0.87 Predicted membrane protein +Tmemb_40 PF10160.2 261 jgi|Monbr1|1039|gw1.5.139.1 - 389 1.6 7.6 3.8 2 2 0.93 1.8e+03 -2.5 0.3 225 242 169 188 154 197 0.61 Predicted membrane protein +DUF3336 PF11815.1 145 jgi|Monbr1|1048|gw1.4.161.1 - 472 3e-33 114.0 0.1 1 1 7.3e-37 4.3e-33 113.5 0.1 14 144 2 132 1 133 0.97 Domain of unknown function (DUF3336) +Patatin PF01734.15 204 jgi|Monbr1|1048|gw1.4.161.1 - 472 2.2e-14 53.5 0.0 1 1 7.3e-18 4.3e-14 52.6 0.0 2 183 140 299 139 316 0.85 Patatin-like phospholipase +PI3_PI4_kinase PF00454.20 235 jgi|Monbr1|1112|gw1.6.86.1 - 332 4e-45 153.7 0.0 1 1 4.4e-49 5.2e-45 153.4 0.0 9 223 30 305 24 323 0.91 Phosphatidylinositol 3- and 4-kinase +LRR_1 PF00560.26 22 jgi|Monbr1|1116|gw1.6.87.1 - 371 0.00087 18.6 7.0 1 4 0.00081 4.8 7.2 0.3 1 22 42 62 42 62 0.88 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1116|gw1.6.87.1 - 371 0.00087 18.6 7.0 2 4 0.014 81 3.5 0.1 2 21 65 83 64 84 0.86 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1116|gw1.6.87.1 - 371 0.00087 18.6 7.0 3 4 0.2 1.2e+03 -0.1 0.0 2 15 87 100 86 106 0.83 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1116|gw1.6.87.1 - 371 0.00087 18.6 7.0 4 4 0.00052 3.1 7.8 0.0 1 14 111 124 111 142 0.74 Leucine Rich Repeat +CS PF04969.9 78 jgi|Monbr1|1116|gw1.6.87.1 - 371 0.011 15.9 0.0 1 1 3.9e-06 0.023 14.9 0.0 20 67 305 347 293 360 0.79 CS domain +MOZ_SAS PF01853.11 189 jgi|Monbr1|1144|gw1.3.222.1 - 246 7.6e-80 266.2 0.1 1 1 3.1e-83 9.2e-80 266.0 0.0 3 186 62 245 60 246 0.99 MOZ/SAS family +Acetyltransf_1 PF00583.17 83 jgi|Monbr1|1144|gw1.3.222.1 - 246 0.022 14.4 0.0 1 1 1.4e-05 0.042 13.5 0.0 3 48 122 162 120 165 0.84 Acetyltransferase (GNAT) family +zf-C2H2 PF00096.19 23 jgi|Monbr1|1144|gw1.3.222.1 - 246 0.047 13.8 0.2 1 1 4.1e-05 0.12 12.5 0.2 1 23 33 56 33 56 0.95 Zinc finger, C2H2 type +FR47 PF08445.3 86 jgi|Monbr1|1144|gw1.3.222.1 - 246 0.088 12.2 0.0 1 2 0.00012 0.37 10.2 0.0 24 42 142 160 135 167 0.90 FR47-like protein +FR47 PF08445.3 86 jgi|Monbr1|1144|gw1.3.222.1 - 246 0.088 12.2 0.0 2 2 0.51 1.5e+03 -1.4 0.0 68 85 226 243 213 244 0.75 FR47-like protein +UPF0052 PF01933.11 301 jgi|Monbr1|1225|gw1.3.240.1 - 319 2.9e-50 171.0 0.0 1 1 2.7e-54 3.2e-50 170.8 0.0 3 234 8 310 6 319 0.94 Uncharacterised protein family UPF0052 +Pkinase PF00069.18 260 jgi|Monbr1|1233|gw1.6.109.1 - 380 5.8e-61 205.6 0.0 1 1 9e-64 1.5e-60 204.2 0.0 1 260 78 368 78 368 0.91 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1233|gw1.6.109.1 - 380 1.5e-29 102.6 0.0 1 2 3.4e-24 5.8e-21 74.4 0.0 3 153 80 226 78 245 0.88 Protein tyrosine kinase +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1233|gw1.6.109.1 - 380 1.5e-29 102.6 0.0 2 2 1.8e-09 3.1e-06 26.1 0.0 162 218 264 319 253 353 0.69 Protein tyrosine kinase +APH PF01636.16 238 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.00048 19.6 6.7 1 3 1.4 2.3e+03 -2.3 0.4 106 134 24 52 15 76 0.52 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.00048 19.6 6.7 2 3 0.0011 1.8 7.8 0.0 17 85 98 170 80 195 0.74 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.00048 19.6 6.7 3 3 5.1e-06 0.0087 15.5 0.1 164 194 194 223 173 224 0.78 Phosphotransferase enzyme family +Pox_ser-thr_kin PF05445.4 434 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.01 14.3 0.0 1 1 9.6e-06 0.016 13.6 0.0 295 312 192 209 179 223 0.77 Poxvirus serine/threonine protein kinase +Kdo PF06293.7 206 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.017 13.8 0.0 1 2 1.7 2.8e+03 -3.2 0.1 156 172 40 56 21 70 0.64 Lipopolysaccharide kinase (Kdo/WaaP) family +Kdo PF06293.7 206 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.017 13.8 0.0 2 2 2.7e-05 0.046 12.4 0.0 104 168 162 223 155 239 0.88 Lipopolysaccharide kinase (Kdo/WaaP) family +Seadorna_VP7 PF07387.4 308 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.05 12.1 0.0 1 1 4.7e-05 0.079 11.4 0.0 153 187 188 220 169 227 0.83 Seadornavirus VP7 +zf-primase PF09329.4 46 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.18 11.1 4.1 1 2 0.0023 4 6.8 1.5 27 44 8 25 5 27 0.82 Primase zinc finger +zf-primase PF09329.4 46 jgi|Monbr1|1233|gw1.6.109.1 - 380 0.18 11.1 4.1 2 2 0.023 40 3.6 0.0 3 16 217 231 216 233 0.80 Primase zinc finger +Glyco_hydro_18 PF00704.21 342 jgi|Monbr1|1237|gw1.4.191.1 - 360 7.3e-88 294.9 0.1 1 1 6.9e-92 8.2e-88 294.7 0.0 6 342 1 344 1 344 0.97 Glycosyl hydrolases family 18 +Pkinase PF00069.18 260 jgi|Monbr1|1270|gw1.2.286.1 - 327 2.8e-59 200.0 0.0 1 1 1.6e-62 3.2e-59 199.9 0.0 5 260 2 264 1 264 0.91 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1270|gw1.2.286.1 - 327 4.4e-26 91.2 0.0 1 1 2.8e-29 5.6e-26 90.9 0.0 5 228 2 225 1 243 0.86 Protein tyrosine kinase +Pkinase_C PF00433.17 49 jgi|Monbr1|1270|gw1.2.286.1 - 327 1.9e-06 27.6 0.3 1 1 2.5e-09 5.1e-06 26.3 0.2 1 47 281 323 281 324 0.84 Protein kinase C terminal domain +Seadorna_VP7 PF07387.4 308 jgi|Monbr1|1270|gw1.2.286.1 - 327 0.0062 15.0 0.0 1 1 4.7e-06 0.0093 14.5 0.0 152 188 107 141 96 145 0.87 Seadornavirus VP7 +Kdo PF06293.7 206 jgi|Monbr1|1270|gw1.2.286.1 - 327 0.02 13.6 0.0 1 1 1.7e-05 0.034 12.9 0.0 131 170 109 145 82 150 0.88 Lipopolysaccharide kinase (Kdo/WaaP) family +APH PF01636.16 238 jgi|Monbr1|1270|gw1.2.286.1 - 327 0.13 11.6 0.2 1 1 0.00017 0.35 10.2 0.1 144 194 94 143 81 146 0.71 Phosphotransferase enzyme family +DUF21 PF01595.13 183 jgi|Monbr1|1294|gw1.3.250.1 - 288 2.3e-31 108.2 1.7 1 1 7.1e-35 2.8e-31 107.9 1.2 2 177 4 170 3 176 0.94 Domain of unknown function DUF21 +CBS PF00571.21 57 jgi|Monbr1|1294|gw1.3.250.1 - 288 0.0042 16.4 0.0 1 3 0.9 3.6e+03 -2.6 0.0 16 34 136 154 133 154 0.85 CBS domain +CBS PF00571.21 57 jgi|Monbr1|1294|gw1.3.250.1 - 288 0.0042 16.4 0.0 2 3 8.6e-06 0.034 13.4 0.0 1 54 196 253 196 256 0.79 CBS domain +CBS PF00571.21 57 jgi|Monbr1|1294|gw1.3.250.1 - 288 0.0042 16.4 0.0 3 3 0.24 9.6e+02 -0.8 0.0 4 27 264 287 261 288 0.77 CBS domain +Col_cuticle_N PF01484.10 53 jgi|Monbr1|1294|gw1.3.250.1 - 288 0.92 8.9 3.8 1 2 0.0014 5.6 6.4 0.3 6 38 8 40 1 43 0.71 Nematode cuticle collagen N-terminal domain +Col_cuticle_N PF01484.10 53 jgi|Monbr1|1294|gw1.3.250.1 - 288 0.92 8.9 3.8 2 2 0.017 69 2.9 0.2 4 16 87 99 86 105 0.89 Nematode cuticle collagen N-terminal domain +Pantoate_transf PF02548.8 261 jgi|Monbr1|1298|gw1.2.299.1 - 286 3.2e-99 330.9 2.4 1 1 3.2e-103 3.9e-99 330.7 1.7 3 259 1 268 1 270 0.97 Ketopantoate hydroxymethyltransferase +efhand PF00036.25 29 jgi|Monbr1|1300|gw1.5.172.1 - 387 3.6e-06 25.5 0.0 1 4 1.6 6.5e+03 -3.4 0.0 15 24 93 102 83 105 0.60 EF hand +efhand PF00036.25 29 jgi|Monbr1|1300|gw1.5.172.1 - 387 3.6e-06 25.5 0.0 2 4 0.095 3.8e+02 0.5 0.0 8 26 119 137 117 140 0.81 EF hand +efhand PF00036.25 29 jgi|Monbr1|1300|gw1.5.172.1 - 387 3.6e-06 25.5 0.0 3 4 3.6e-05 0.14 11.2 0.0 9 24 226 241 223 243 0.91 EF hand +efhand PF00036.25 29 jgi|Monbr1|1300|gw1.5.172.1 - 387 3.6e-06 25.5 0.0 4 4 0.00027 1.1 8.4 0.0 2 26 287 311 286 314 0.80 EF hand +SPARC_Ca_bdg PF10591.2 113 jgi|Monbr1|1300|gw1.5.172.1 - 387 0.012 15.3 0.0 1 2 2.2e-05 0.086 12.5 0.0 47 81 210 244 182 257 0.78 Secreted protein acidic and rich in cysteine Ca binding region +SPARC_Ca_bdg PF10591.2 113 jgi|Monbr1|1300|gw1.5.172.1 - 387 0.012 15.3 0.0 2 2 0.17 6.9e+02 -0.1 0.0 54 81 285 321 277 355 0.67 Secreted protein acidic and rich in cysteine Ca binding region +Pex26 PF07163.5 309 jgi|Monbr1|1300|gw1.5.172.1 - 387 0.053 12.1 0.1 1 1 1.8e-05 0.073 11.6 0.1 259 304 265 310 143 315 0.65 Pex26 protein +DUF3459 PF11941.1 115 jgi|Monbr1|1351|gw1.2.310.1 - 365 0.072 12.4 1.3 1 1 3e-05 0.36 10.2 0.5 9 44 278 313 270 333 0.84 Domain of unknown function (DUF3459) +RRM_1 PF00076.15 70 jgi|Monbr1|1352|gw1.2.311.1 - 431 3.5e-24 83.9 0.2 1 4 0.00016 1.9 7.8 0.0 1 20 93 112 93 114 0.95 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +RRM_1 PF00076.15 70 jgi|Monbr1|1352|gw1.2.311.1 - 431 3.5e-24 83.9 0.2 2 4 1.6e-06 0.019 14.2 0.0 24 70 127 167 121 167 0.88 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +RRM_1 PF00076.15 70 jgi|Monbr1|1352|gw1.2.311.1 - 431 3.5e-24 83.9 0.2 3 4 3.6e-13 4.3e-09 35.5 0.0 3 49 218 265 216 288 0.86 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +RRM_1 PF00076.15 70 jgi|Monbr1|1352|gw1.2.311.1 - 431 3.5e-24 83.9 0.2 4 4 1.2e-08 0.00014 21.0 0.0 13 69 356 416 355 417 0.88 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +CwfJ_C_1 PF04677.8 122 jgi|Monbr1|1359|gw1.4.211.1 - 292 8.4e-27 92.9 0.4 1 1 2.8e-30 1.1e-26 92.5 0.3 3 122 89 211 87 211 0.97 Protein similar to CwfJ C-terminus 1 +CwfJ_C_2 PF04676.7 98 jgi|Monbr1|1359|gw1.4.211.1 - 292 1.4e-14 54.0 0.0 1 1 8.3e-18 3.3e-14 52.8 0.0 1 73 220 288 220 292 0.94 Protein similar to CwfJ C-terminus 2 +DcpS_C PF11969.1 114 jgi|Monbr1|1359|gw1.4.211.1 - 292 0.068 13.1 0.0 1 1 2.9e-05 0.12 12.3 0.0 21 77 120 176 96 204 0.75 Scavenger mRNA decapping enzyme C-term binding +PLDc PF00614.15 28 jgi|Monbr1|1366|gw1.2.312.1 - 411 3.1e-05 23.3 0.4 1 2 0.00061 7.3 6.2 0.1 5 28 135 158 133 158 0.91 Phospholipase D Active site motif +PLDc PF00614.15 28 jgi|Monbr1|1366|gw1.2.312.1 - 411 3.1e-05 23.3 0.4 2 2 1.6e-06 0.019 14.4 0.0 1 16 331 346 331 353 0.87 Phospholipase D Active site motif +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 1 7 0.00014 0.82 9.3 0.0 19 39 5 25 2 25 0.91 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 2 7 0.047 2.8e+02 1.3 0.1 17 36 49 68 45 70 0.81 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 3 7 0.4 2.4e+03 -1.7 0.0 16 39 96 119 95 119 0.74 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 4 7 8.9e-13 5.3e-09 35.3 0.3 7 39 129 162 126 162 0.96 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 5 7 1.9e-11 1.1e-07 31.1 0.2 2 39 172 209 171 209 0.97 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 6 7 8.3e-06 0.049 13.2 0.0 18 39 263 288 261 288 0.92 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|1381|gw1.6.124.1 - 321 6.7e-28 95.2 15.0 7 7 0.00011 0.66 9.6 0.0 14 29 306 321 303 321 0.93 WD domain, G-beta repeat +PQQ PF01011.14 38 jgi|Monbr1|1381|gw1.6.124.1 - 321 0.0011 18.1 0.1 1 2 0.048 2.9e+02 0.9 0.0 1 18 9 27 9 27 0.92 PQQ enzyme repeat +PQQ PF01011.14 38 jgi|Monbr1|1381|gw1.6.124.1 - 321 0.0011 18.1 0.1 2 2 3.2e-06 0.019 14.1 0.0 3 25 275 297 273 303 0.88 PQQ enzyme repeat +Helicase_C PF00271.24 78 jgi|Monbr1|1393|gw1.5.188.1 - 304 3.3e-09 36.1 0.0 1 1 1.7e-12 6.7e-09 35.1 0.0 6 78 198 280 194 280 0.92 Helicase conserved C-terminal domain +DEAD PF00270.22 167 jgi|Monbr1|1393|gw1.5.188.1 - 304 0.016 14.3 0.0 1 1 1.2e-05 0.046 12.8 0.0 17 83 16 70 5 144 0.87 DEAD/DEAH box helicase +Zot PF05707.5 193 jgi|Monbr1|1393|gw1.5.188.1 - 304 0.049 12.7 0.0 1 2 2.5e-05 0.1 11.7 0.0 2 97 15 111 14 169 0.76 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|1393|gw1.5.188.1 - 304 0.049 12.7 0.0 2 2 0.97 3.9e+03 -3.2 0.0 5 30 272 297 271 300 0.80 Zonular occludens toxin (Zot) +TTL PF03133.8 294 jgi|Monbr1|1395|gw1.5.189.1 - 367 1.7e-82 276.3 0.0 1 1 3.6e-86 2.2e-82 276.0 0.0 8 284 50 341 44 350 0.96 Tubulin-tyrosine ligase family +RimK PF08443.4 190 jgi|Monbr1|1395|gw1.5.189.1 - 367 0.018 14.2 0.0 1 2 0.0022 13 4.8 0.0 33 75 108 150 85 193 0.69 RimK-like ATP-grasp domain +RimK PF08443.4 190 jgi|Monbr1|1395|gw1.5.189.1 - 367 0.018 14.2 0.0 2 2 0.00043 2.6 7.1 0.0 129 174 268 323 258 336 0.71 RimK-like ATP-grasp domain +60KD_IMP PF02096.13 196 jgi|Monbr1|1400|gw1.2.322.1 - 235 1.3e-45 155.1 3.8 1 1 1.3e-49 1.5e-45 154.9 2.7 3 193 27 220 25 223 0.91 60Kd inner membrane protein +Octopine_DH PF02317.10 152 jgi|Monbr1|1409|gw1.4.217.1 - 376 1.1e-33 115.6 0.0 1 1 5.7e-37 1.7e-33 115.1 0.0 3 151 194 362 192 363 0.96 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain +NAD_Gly3P_dh_N PF01210.16 159 jgi|Monbr1|1409|gw1.4.217.1 - 376 3.9e-05 23.0 0.0 1 1 3.5e-08 0.0001 21.7 0.0 3 135 1 140 1 160 0.76 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus +ApbA PF02558.9 151 jgi|Monbr1|1409|gw1.4.217.1 - 376 0.034 13.2 0.0 1 1 1.8e-05 0.054 12.6 0.0 1 97 1 107 1 111 0.69 Ketopantoate reductase PanE/ApbA +OCD_Mu_crystall PF02423.8 314 jgi|Monbr1|1409|gw1.4.217.1 - 376 0.11 10.9 0.0 1 1 6.2e-05 0.18 10.1 0.0 178 225 62 111 47 139 0.85 Ornithine cyclodeaminase/mu-crystallin family +Kinesin PF00225.16 333 jgi|Monbr1|1417|gw1.6.130.1 - 343 2.2e-94 315.6 0.0 1 1 6.4e-98 2.5e-94 315.3 0.0 32 329 61 341 31 343 0.91 Kinesin motor domain +PhoH PF02562.9 205 jgi|Monbr1|1417|gw1.6.130.1 - 343 0.11 11.4 0.0 1 1 4.3e-05 0.17 10.7 0.0 20 89 103 176 89 212 0.79 PhoH-like protein +DUF87 PF01935.10 229 jgi|Monbr1|1417|gw1.6.130.1 - 343 0.28 10.6 2.1 1 2 0.0011 4.4 6.7 0.2 30 40 109 119 105 120 0.92 Domain of unknown function DUF87 +DUF87 PF01935.10 229 jgi|Monbr1|1417|gw1.6.130.1 - 343 0.28 10.6 2.1 2 2 0.012 46 3.4 0.1 89 214 149 256 127 274 0.61 Domain of unknown function DUF87 +JmjC PF02373.15 114 jgi|Monbr1|1419|gw1.7.125.1 - 360 2.5e-19 69.2 0.0 1 1 5.3e-22 1.6e-18 66.7 0.0 1 114 247 358 247 358 0.86 JmjC domain +Cupin_4 PF08007.5 319 jgi|Monbr1|1419|gw1.7.125.1 - 360 1.8e-05 23.7 0.0 1 2 0.062 1.9e+02 0.7 0.0 190 266 153 235 151 241 0.82 Cupin superfamily protein +Cupin_4 PF08007.5 319 jgi|Monbr1|1419|gw1.7.125.1 - 360 1.8e-05 23.7 0.0 2 2 6.9e-08 0.00021 20.3 0.0 173 206 322 355 308 360 0.85 Cupin superfamily protein +Cupin_2 PF07883.4 71 jgi|Monbr1|1419|gw1.7.125.1 - 360 0.0027 16.8 0.0 1 2 2.4 7.2e+03 -3.8 0.0 44 52 256 264 253 276 0.57 Cupin domain +Cupin_2 PF07883.4 71 jgi|Monbr1|1419|gw1.7.125.1 - 360 0.0027 16.8 0.0 2 2 2.6e-06 0.0077 15.4 0.0 40 63 328 351 324 355 0.86 Cupin domain +F-box PF00646.26 48 jgi|Monbr1|1419|gw1.7.125.1 - 360 0.02 14.2 1.1 1 2 9.3e-06 0.028 13.7 0.0 5 30 11 36 9 50 0.91 F-box domain +F-box PF00646.26 48 jgi|Monbr1|1419|gw1.7.125.1 - 360 0.02 14.2 1.1 2 2 2.2 6.4e+03 -3.4 0.1 33 44 269 280 268 281 0.86 F-box domain +TBC PF00566.11 214 jgi|Monbr1|1452|gw1.8.161.1 - 321 5e-30 104.2 5.2 1 2 3.8e-22 2.2e-18 66.2 0.6 4 130 29 209 27 222 0.85 TBC domain +TBC PF00566.11 214 jgi|Monbr1|1452|gw1.8.161.1 - 321 5e-30 104.2 5.2 2 2 4.7e-14 2.8e-10 39.7 0.1 143 210 251 320 236 321 0.87 TBC domain +DUF2017 PF09438.3 181 jgi|Monbr1|1452|gw1.8.161.1 - 321 0.047 12.9 0.2 1 1 1.4e-05 0.085 12.1 0.2 53 170 19 136 16 139 0.77 Domain of unknown function (DUF2017) +MFS_1 PF07690.9 353 jgi|Monbr1|1453|gw1.4.228.1 - 382 2.9e-05 22.6 37.6 1 1 3.9e-07 0.00092 17.7 22.4 28 352 20 355 4 356 0.74 Major Facilitator Superfamily +BT1 PF03092.9 433 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.0047 15.3 2.8 1 3 2e-06 0.0047 15.3 1.9 30 127 28 137 18 158 0.70 BT1 family +BT1 PF03092.9 433 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.0047 15.3 2.8 2 3 0.068 1.6e+02 0.4 1.2 91 158 216 279 195 284 0.76 BT1 family +BT1 PF03092.9 433 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.0047 15.3 2.8 3 3 0.0037 8.8 4.6 1.6 92 161 306 376 266 379 0.75 BT1 family +DUF3457 PF11939.1 156 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.038 13.1 0.6 1 2 0.00014 0.33 10.1 0.1 39 82 22 64 9 69 0.73 Protein of unknown function (DUF3457) +DUF3457 PF11939.1 156 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.038 13.1 0.6 2 2 0.14 3.4e+02 0.3 0.0 112 133 191 212 182 214 0.84 Protein of unknown function (DUF3457) +Sugar_tr PF00083.17 451 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.061 11.5 14.9 1 3 0.022 53 1.8 0.1 314 399 55 145 39 171 0.71 Sugar (and other) transporter +Sugar_tr PF00083.17 451 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.061 11.5 14.9 2 3 0.0033 8 4.6 2.5 14 84 221 283 209 309 0.76 Sugar (and other) transporter +Sugar_tr PF00083.17 451 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.061 11.5 14.9 3 3 2e-05 0.047 11.9 0.6 31 80 324 373 293 378 0.71 Sugar (and other) transporter +PUCC PF03209.8 403 jgi|Monbr1|1453|gw1.4.228.1 - 382 0.31 9.3 26.9 1 1 0.0013 3.2 6.0 18.6 190 364 191 366 56 371 0.80 PUCC protein +Met_10 PF02475.9 200 jgi|Monbr1|1458|gw1.7.132.1 - 296 2e-71 239.4 0.0 1 1 1.6e-74 2.4e-71 239.1 0.0 2 191 24 224 23 243 0.93 Met-10+ like-protein +TRM PF02005.9 377 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.00074 18.2 0.0 1 1 7.4e-07 0.0011 17.6 0.0 69 115 143 185 96 195 0.82 N2,N2-dimethylguanosine tRNA methyltransferase +PrmA PF06325.6 295 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.012 14.4 0.0 1 1 1.2e-05 0.017 13.9 0.0 155 220 117 181 114 215 0.86 Ribosomal protein L11 methyltransferase (PrmA) +tRNA_U5-meth_tr PF05958.4 352 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.015 13.7 0.0 1 1 1.5e-05 0.022 13.1 0.0 201 245 128 172 112 182 0.89 tRNA (Uracil-5-)-methyltransferase +TehB PF03848.7 192 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.017 14.0 0.0 1 1 1.8e-05 0.027 13.3 0.0 8 87 100 180 94 191 0.89 Tellurite resistance protein TehB +MethyltransfD12 PF02086.8 260 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.029 13.5 0.0 1 1 3e-05 0.045 12.8 0.0 16 70 121 174 113 181 0.81 D12 class N6 adenine-specific DNA methyltransferase +RrnaAD PF00398.13 262 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.042 12.5 0.0 1 2 0.19 2.9e+02 -0.1 0.0 80 108 4 34 3 37 0.88 Ribosomal RNA adenine dimethylase +RrnaAD PF00398.13 262 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.042 12.5 0.0 2 2 0.00021 0.32 9.6 0.0 15 84 107 180 98 186 0.84 Ribosomal RNA adenine dimethylase +Methyltransf_15 PF09445.3 164 jgi|Monbr1|1458|gw1.7.132.1 - 296 0.057 12.6 0.0 1 1 7.3e-05 0.11 11.7 0.0 2 64 125 187 124 195 0.91 RNA cap guanine-N2 methyltransferase +DNA_methylase PF00145.10 335 jgi|Monbr1|1464|gw1.2.331.1 - 356 1.2e-28 99.9 0.0 1 1 1.3e-31 1.6e-27 96.2 0.0 37 330 1 354 1 355 0.66 C-5 cytosine-specific DNA methylase +JmjC PF02373.15 114 jgi|Monbr1|1474|gw1.8.163.1 - 293 2.1e-20 72.7 0.0 1 1 5.5e-24 3.3e-20 72.1 0.0 1 114 117 227 117 227 0.91 JmjC domain +GPI PF06560.4 182 jgi|Monbr1|1474|gw1.8.163.1 - 293 0.006 15.3 0.1 1 1 1.6e-06 0.0096 14.6 0.1 115 145 199 229 186 243 0.85 Glucose-6-phosphate isomerase (GPI) +Peptidase_A22B PF04258.6 301 jgi|Monbr1|1476|gw1.4.234.1 - 287 1.2e-55 188.7 7.0 1 1 4.9e-58 5.8e-54 183.2 4.8 10 298 2 287 1 287 0.86 Signal peptide peptidase +CBAH PF02275.11 316 jgi|Monbr1|1488|gw1.4.237.1 - 250 5.4e-10 38.8 0.0 1 1 6e-14 7.2e-10 38.4 0.0 1 194 36 206 36 243 0.78 Linear amide C-N hydrolases, choloylglycine hydrolase family +DUF914 PF06027.5 335 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.3e-95 319.7 13.7 1 1 1.1e-98 1.6e-95 319.5 9.5 9 303 4 296 1 299 0.97 Eukaryotic protein of unknown function (DUF914) +TPT PF03151.9 153 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.5e-10 40.6 21.8 1 3 0.16 2.5e+02 0.9 0.1 36 87 7 54 3 64 0.67 Triose-phosphate Transporter family +TPT PF03151.9 153 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.5e-10 40.6 21.8 2 3 2.7e-05 0.04 13.2 1.1 102 148 93 139 72 145 0.79 Triose-phosphate Transporter family +TPT PF03151.9 153 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.5e-10 40.6 21.8 3 3 1.1e-11 1.6e-08 33.9 6.2 5 151 166 296 164 298 0.91 Triose-phosphate Transporter family +UAA PF08449.4 303 jgi|Monbr1|1512|gw1.2.347.1 - 300 3.9e-10 38.8 10.1 1 1 4.7e-13 6.9e-10 37.9 7.0 40 295 44 296 4 300 0.79 UAA transporter family +EamA PF00892.13 126 jgi|Monbr1|1512|gw1.2.347.1 - 300 2.3e-08 33.8 21.7 1 2 4.4e-05 0.066 12.9 2.8 28 125 48 143 19 144 0.84 EamA-like transporter family +EamA PF00892.13 126 jgi|Monbr1|1512|gw1.2.347.1 - 300 2.3e-08 33.8 21.7 2 2 2e-09 2.9e-06 27.0 6.7 2 123 172 295 171 298 0.89 EamA-like transporter family +Nuc_sug_transp PF04142.8 238 jgi|Monbr1|1512|gw1.2.347.1 - 300 0.00028 19.8 7.6 1 1 3.9e-07 0.00058 18.8 5.2 30 238 85 289 61 289 0.80 Nucleotide-sugar transporter +DUF803 PF05653.7 300 jgi|Monbr1|1512|gw1.2.347.1 - 300 0.0027 16.4 1.5 1 2 1.8e-06 0.0027 16.4 1.1 46 159 66 179 49 210 0.76 Protein of unknown function (DUF803) +DUF803 PF05653.7 300 jgi|Monbr1|1512|gw1.2.347.1 - 300 0.0027 16.4 1.5 2 2 0.49 7.3e+02 -1.5 0.1 90 116 266 292 230 294 0.66 Protein of unknown function (DUF803) +DUF1686 PF07937.4 185 jgi|Monbr1|1512|gw1.2.347.1 - 300 0.081 12.2 1.3 1 2 0.00015 0.23 10.7 0.7 74 150 108 182 96 209 0.80 Protein of unknown function (DUF1686) +DUF1686 PF07937.4 185 jgi|Monbr1|1512|gw1.2.347.1 - 300 0.081 12.2 1.3 2 2 1.1 1.6e+03 -1.8 0.0 75 95 204 224 183 231 0.59 Protein of unknown function (DUF1686) +DUF3185 PF11381.1 59 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.6 8.2 4.0 1 3 3.6 5.4e+03 -3.1 0.0 5 17 132 144 130 152 0.75 Protein of unknown function (DUF3185) +DUF3185 PF11381.1 59 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.6 8.2 4.0 2 3 0.58 8.7e+02 -0.6 0.2 41 58 224 241 222 242 0.70 Protein of unknown function (DUF3185) +DUF3185 PF11381.1 59 jgi|Monbr1|1512|gw1.2.347.1 - 300 1.6 8.2 4.0 3 3 0.0012 1.8 8.1 0.1 40 57 277 294 270 296 0.87 Protein of unknown function (DUF3185) +Kinesin PF00225.16 333 jgi|Monbr1|1544|gw1.3.292.1 - 296 1.1e-91 306.7 0.0 1 1 1e-95 1.2e-91 306.6 0.0 32 331 8 292 1 294 0.93 Kinesin motor domain +MFS_1 PF07690.9 353 jgi|Monbr1|1561|gw1.2.362.1 - 364 1.4e-32 112.5 21.0 1 1 6.9e-36 1.6e-32 112.3 14.6 42 353 1 354 1 354 0.81 Major Facilitator Superfamily +Sugar_tr PF00083.17 451 jgi|Monbr1|1561|gw1.2.362.1 - 364 9.5e-05 20.8 14.0 1 1 8.2e-08 0.0002 19.7 9.7 57 402 2 354 1 362 0.75 Sugar (and other) transporter +PUCC PF03209.8 403 jgi|Monbr1|1561|gw1.2.362.1 - 364 0.023 13.1 0.1 1 1 1.9e-05 0.046 12.1 0.1 70 207 24 176 2 191 0.71 PUCC protein +MerE PF05052.5 75 jgi|Monbr1|1561|gw1.2.362.1 - 364 0.18 11.5 0.1 1 4 0.028 67 3.2 1.3 16 55 7 47 4 67 0.62 MerE protein +MerE PF05052.5 75 jgi|Monbr1|1561|gw1.2.362.1 - 364 0.18 11.5 0.1 2 4 0.99 2.4e+03 -1.8 0.1 42 54 76 88 48 93 0.68 MerE protein +MerE PF05052.5 75 jgi|Monbr1|1561|gw1.2.362.1 - 364 0.18 11.5 0.1 3 4 7.5e-05 0.18 11.5 0.1 29 54 125 148 115 151 0.83 MerE protein +MerE PF05052.5 75 jgi|Monbr1|1561|gw1.2.362.1 - 364 0.18 11.5 0.1 4 4 0.65 1.6e+03 -1.2 0.6 17 33 298 314 268 318 0.63 MerE protein +DUF2142 PF09913.2 389 jgi|Monbr1|1561|gw1.2.362.1 - 364 1.5 7.1 7.2 1 1 0.0014 3.3 5.9 5.0 148 363 21 283 6 295 0.58 Predicted membrane protein (DUF2142) +4HBT PF03061.15 79 jgi|Monbr1|1579|gw1.2.366.1 - 327 1.2e-27 95.4 0.5 1 2 6.5e-18 7.7e-14 51.2 0.0 2 76 19 101 18 104 0.96 Thioesterase superfamily +4HBT PF03061.15 79 jgi|Monbr1|1579|gw1.2.366.1 - 327 1.2e-27 95.4 0.5 2 2 3.5e-15 4.2e-11 42.5 0.0 2 74 200 271 199 276 0.91 Thioesterase superfamily +Glyco_hydro_18 PF00704.21 342 jgi|Monbr1|1599|gw1.7.144.1 - 307 1.1e-17 64.1 0.0 1 1 1.2e-21 1.4e-17 63.8 0.0 4 341 2 298 1 299 0.79 Glycosyl hydrolases family 18 +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1610|gw1.2.379.1 - 251 8.2e-87 290.2 0.0 1 1 1.6e-90 9.4e-87 290.0 0.0 31 259 1 227 1 227 0.97 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|1610|gw1.2.379.1 - 251 1.5e-40 138.7 0.0 1 1 3e-44 1.8e-40 138.4 0.0 27 256 1 225 1 227 0.88 Protein kinase domain +PAE PF03283.6 366 jgi|Monbr1|1630|gw1.8.184.1 - 325 4.3e-65 219.4 7.5 1 1 1.3e-68 1.5e-64 217.5 5.2 29 361 1 324 1 325 0.92 Pectinacetylesterase +HlyIII PF03006.13 221 jgi|Monbr1|1642|gw1.2.388.1 - 255 1.2e-51 174.9 28.2 1 1 3.5e-55 1.4e-51 174.7 19.5 1 221 29 255 29 255 0.94 Haemolysin-III related +TRI12 PF06609.6 599 jgi|Monbr1|1642|gw1.2.388.1 - 255 0.12 10.2 1.2 1 1 4e-05 0.16 9.8 0.9 177 288 47 157 27 174 0.67 Fungal trichothecene efflux pump (TRI12) +DUF2684 PF10885.1 89 jgi|Monbr1|1642|gw1.2.388.1 - 255 0.53 9.8 2.1 1 1 0.00026 1 8.9 1.0 25 67 36 79 26 91 0.77 Protein of unknown function (DUF2684) +Peptidase_M20 PF01546.21 171 jgi|Monbr1|1658|gw1.3.312.1 - 330 1.2e-17 63.7 0.2 1 1 4.2e-21 1.7e-17 63.2 0.1 1 135 57 326 57 329 0.90 Peptidase family M20/M25/M40 +M20_dimer PF07687.7 109 jgi|Monbr1|1658|gw1.3.312.1 - 330 3.6e-09 36.0 0.1 1 1 1.8e-12 7.2e-09 35.0 0.0 8 101 168 259 165 264 0.91 Peptidase dimerisation domain +Neocarzinostat PF00960.11 110 jgi|Monbr1|1658|gw1.3.312.1 - 330 0.71 9.5 3.2 1 2 0.32 1.3e+03 -1.0 0.1 82 103 160 181 151 196 0.62 Neocarzinostatin family +Neocarzinostat PF00960.11 110 jgi|Monbr1|1658|gw1.3.312.1 - 330 0.71 9.5 3.2 2 2 0.00015 0.58 9.8 0.2 16 61 214 259 205 296 0.74 Neocarzinostatin family +JmjC PF02373.15 114 jgi|Monbr1|1660|gw1.8.185.1 - 304 3.3e-40 136.5 0.0 1 1 8.7e-44 5.2e-40 135.9 0.0 1 114 73 189 73 189 0.97 JmjC domain +zf-C5HC2 PF02928.9 54 jgi|Monbr1|1660|gw1.8.185.1 - 304 0.093 12.5 2.1 1 1 2.7e-05 0.16 11.8 1.5 1 20 279 298 279 304 0.88 C5HC2 zinc finger +AAA PF00004.22 130 jgi|Monbr1|1680|gw1.4.258.1 - 226 5.9e-32 110.3 0.0 1 1 1.9e-34 8.2e-32 109.8 0.0 1 129 50 195 50 196 0.92 ATPase family associated with various cellular activities (AAA) +AAA_2 PF07724.7 171 jgi|Monbr1|1680|gw1.4.258.1 - 226 2e-05 24.2 0.0 1 1 7.1e-08 3.1e-05 23.6 0.0 5 104 49 160 47 179 0.84 AAA domain (Cdc48 subfamily) +NACHT PF05729.5 166 jgi|Monbr1|1680|gw1.4.258.1 - 226 2.9e-05 23.4 0.4 1 1 1.5e-06 0.00067 19.0 0.3 2 127 49 174 48 183 0.56 NACHT domain +Viral_helicase1 PF01443.11 226 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0001 21.7 0.0 1 1 3.3e-07 0.00015 21.1 0.0 1 71 50 133 50 144 0.91 Viral (Superfamily 1) RNA helicase +UPF0079 PF02367.10 123 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.00031 20.0 0.0 1 1 1.2e-06 0.00052 19.3 0.0 15 54 47 83 39 94 0.83 Uncharacterised P-loop hydrolase UPF0079 +Mg_chelatase PF01078.14 207 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.00047 19.0 0.0 1 2 4.2e-06 0.0019 17.1 0.0 22 78 47 108 43 147 0.68 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.00047 19.0 0.0 2 2 1.2 5.3e+02 -0.7 0.0 185 200 180 195 166 201 0.80 Magnesium chelatase, subunit ChlI +IstB PF01695.10 178 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.00057 19.0 0.0 1 2 3.6e-06 0.0016 17.5 0.0 44 70 44 70 39 91 0.89 IstB-like ATP binding protein +IstB PF01695.10 178 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.00057 19.0 0.0 2 2 5.5 2.4e+03 -2.6 0.0 86 120 128 165 111 167 0.52 IstB-like ATP binding protein +AAA_5 PF07728.7 139 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.00083 18.7 0.1 1 1 3.5e-06 0.0015 17.9 0.1 2 77 50 132 49 188 0.63 AAA domain (dynein-related subfamily) +Arch_ATPase PF01637.11 234 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0012 18.3 0.1 1 1 0.00027 0.12 11.7 0.1 22 131 49 133 44 181 0.59 Archaeal ATPase +DUF815 PF05673.6 250 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0012 17.4 0.0 1 1 5.2e-06 0.0023 16.5 0.0 54 92 48 92 44 130 0.83 Protein of unknown function (DUF815) +RuvB_N PF05496.5 234 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0016 17.1 0.0 1 1 7.1e-06 0.0031 16.2 0.0 52 76 49 73 21 82 0.92 Holliday junction DNA helicase ruvB N-terminus +RNA_helicase PF00910.15 107 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0016 18.2 0.0 1 1 6.6e-06 0.0029 17.4 0.0 1 23 50 72 50 98 0.87 RNA helicase +KAP_NTPase PF07693.7 325 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0036 16.0 0.0 1 2 0.0017 0.75 8.4 0.0 22 44 49 71 39 83 0.90 KAP family P-loop domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0036 16.0 0.0 2 2 0.011 5 5.6 0.0 139 190 88 138 73 142 0.80 KAP family P-loop domain +Zeta_toxin PF06414.5 201 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0039 16.0 0.0 1 1 1.3e-05 0.0057 15.4 0.0 11 42 41 76 32 140 0.79 Zeta toxin +TIP49 PF06068.6 398 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0051 15.2 0.0 1 1 1.3e-05 0.0059 15.0 0.0 51 75 48 72 17 147 0.86 TIP49 C-terminus +PduV-EutP PF10662.2 143 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.0096 15.1 0.0 1 1 4.4e-05 0.019 14.1 0.0 2 24 48 70 47 93 0.84 Ethanolamine utilisation - propanediol utilisation +DUF2075 PF09848.2 352 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.032 12.9 0.0 1 1 9.8e-05 0.043 12.4 0.0 2 96 48 133 47 190 0.60 Uncharacterized conserved protein (DUF2075) +GSPII_E PF00437.13 282 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.034 12.7 0.1 1 2 0.00019 0.083 11.4 0.0 135 162 44 71 35 77 0.90 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.034 12.7 0.1 2 2 3.3 1.5e+03 -2.5 0.0 154 177 106 130 99 156 0.56 Type II/IV secretion system protein +Sigma54_activat PF00158.19 168 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.044 12.9 0.0 1 1 0.00019 0.084 12.0 0.0 20 69 45 95 39 138 0.74 Sigma-54 interaction domain +AAA_3 PF07726.4 131 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.049 12.9 0.0 1 1 0.00023 0.1 11.8 0.0 2 25 50 73 49 82 0.91 ATPase family associated with various cellular activities (AAA) +MobB PF03205.7 137 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.056 12.9 0.0 1 2 0.00037 0.17 11.4 0.0 3 25 50 72 48 91 0.87 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.056 12.9 0.0 2 2 2.6 1.1e+03 -1.1 0.0 61 61 155 155 97 219 0.59 Molybdopterin guanine dinucleotide synthesis protein B +Parvo_NS1 PF01057.10 272 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.064 11.8 0.0 1 1 0.00023 0.1 11.1 0.0 116 137 49 70 45 74 0.91 Parvovirus non-structural protein NS1 +KTI12 PF08433.3 270 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.066 12.0 0.0 1 1 0.0002 0.087 11.6 0.0 4 47 50 93 48 140 0.63 Chromatin associated protein KTI12 +PhoH PF02562.9 205 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.069 12.0 0.0 1 3 0.00059 0.26 10.1 0.0 18 42 46 70 40 83 0.85 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.069 12.0 0.0 2 3 7 3.1e+03 -3.2 0.0 122 134 123 135 111 167 0.69 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.069 12.0 0.0 3 3 3.1 1.4e+03 -2.0 0.0 182 201 204 223 200 225 0.81 PhoH-like protein +Rad17 PF03215.8 498 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.073 11.5 0.0 1 1 0.00021 0.093 11.1 0.0 46 138 48 130 40 181 0.59 Rad17 cell cycle checkpoint protein +DUF265 PF03266.8 168 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.076 12.4 0.2 1 2 0.00053 0.23 10.8 0.1 2 23 50 71 49 75 0.91 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.076 12.4 0.2 2 2 3.1 1.4e+03 -1.5 0.0 94 104 117 129 97 135 0.60 Protein of unknown function, DUF265 +DUF258 PF03193.9 161 jgi|Monbr1|1680|gw1.4.258.1 - 226 0.083 11.7 0.0 1 1 0.00025 0.11 11.3 0.0 35 60 47 72 25 123 0.86 Protein of unknown function, DUF258 +CAF1 PF04857.13 262 jgi|Monbr1|1697|gw1.2.411.1 - 231 7.1e-30 103.8 0.0 1 1 8.9e-34 1.1e-29 103.3 0.0 2 218 3 205 2 218 0.93 CAF1 family ribonuclease +ADH_N PF08240.5 109 jgi|Monbr1|1704|gw1.3.327.1 - 275 3.2e-11 42.6 0.1 1 1 2.7e-14 8e-11 41.3 0.0 2 65 26 91 25 134 0.87 Alcohol dehydrogenase GroES-like domain +ADH_zinc_N PF00107.19 130 jgi|Monbr1|1704|gw1.3.327.1 - 275 2.4e-08 33.3 0.0 1 1 1.7e-11 5.1e-08 32.2 0.0 1 115 152 272 152 274 0.88 Zinc-binding dehydrogenase +adh_short PF00106.18 167 jgi|Monbr1|1704|gw1.3.327.1 - 275 5.1e-06 26.1 1.2 1 1 3.8e-09 1.1e-05 25.0 0.8 6 99 147 235 142 244 0.88 short chain dehydrogenase +KR PF08659.3 181 jgi|Monbr1|1704|gw1.3.327.1 - 275 0.0015 17.9 0.5 1 1 8.7e-07 0.0026 17.1 0.3 6 77 147 215 143 239 0.87 KR domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1712|gw1.8.192.1 - 264 4.6e-77 258.3 0.0 1 1 1.8e-80 5.2e-77 258.1 0.0 1 259 10 258 10 258 0.97 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|1712|gw1.8.192.1 - 264 2.6e-47 160.8 0.0 1 1 1e-50 3e-47 160.6 0.0 2 256 11 256 10 259 0.90 Protein kinase domain +RIO1 PF01163.15 187 jgi|Monbr1|1712|gw1.8.192.1 - 264 0.0085 15.1 0.0 1 1 4.9e-06 0.015 14.3 0.0 50 157 46 155 18 158 0.73 RIO1 family +APH PF01636.16 238 jgi|Monbr1|1712|gw1.8.192.1 - 264 0.0088 15.4 0.1 1 2 0.001 3.1 7.1 0.0 5 59 16 71 13 115 0.77 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|1712|gw1.8.192.1 - 264 0.0088 15.4 0.1 2 2 0.0014 4.1 6.7 0.0 144 198 104 153 90 189 0.74 Phosphotransferase enzyme family +Pkinase PF00069.18 260 jgi|Monbr1|1727|gw1.4.264.1 - 251 2.6e-56 190.3 0.0 1 1 1e-59 3e-56 190.1 0.0 48 258 1 230 1 232 0.91 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1727|gw1.4.264.1 - 251 2.5e-39 134.6 0.0 1 1 1.1e-42 3.3e-39 134.2 0.0 51 256 1 227 1 230 0.83 Protein tyrosine kinase +Kdo PF06293.7 206 jgi|Monbr1|1727|gw1.4.264.1 - 251 0.053 12.2 0.0 1 1 2.5e-05 0.074 11.7 0.0 114 166 53 102 9 119 0.84 Lipopolysaccharide kinase (Kdo/WaaP) family +Seadorna_VP7 PF07387.4 308 jgi|Monbr1|1727|gw1.4.264.1 - 251 0.086 11.3 0.1 1 1 4.4e-05 0.13 10.7 0.1 147 187 63 101 42 111 0.77 Seadornavirus VP7 +Y_phosphatase PF00102.20 235 jgi|Monbr1|1775|gw1.8.202.1 - 253 2.6e-72 242.6 0.0 1 1 5e-76 3e-72 242.5 0.0 1 233 14 253 14 253 0.96 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|1775|gw1.8.202.1 - 253 0.0047 16.1 0.2 1 1 1.7e-06 0.01 15.1 0.1 77 92 193 208 174 209 0.90 Dual specificity phosphatase, catalytic domain +Pkinase PF00069.18 260 jgi|Monbr1|1780|gw1.4.274.1 - 221 2.9e-48 163.9 0.0 1 1 5.9e-52 3.5e-48 163.7 0.0 10 193 1 198 1 208 0.95 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1780|gw1.4.274.1 - 221 4.7e-43 146.8 0.0 1 1 1e-46 6.1e-43 146.4 0.0 10 201 1 200 1 212 0.87 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|1800|gw1.3.352.1 - 222 7.1e-55 185.6 0.0 1 1 1.4e-58 8.3e-55 185.4 0.0 1 202 2 212 2 221 0.91 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1800|gw1.3.352.1 - 222 3.1e-34 117.9 0.0 1 1 7.3e-38 4.3e-34 117.4 0.0 3 214 4 217 2 221 0.88 Protein tyrosine kinase +BP28CT PF08146.5 154 jgi|Monbr1|1836|gw1.7.152.1 - 242 2.7e-22 78.8 0.0 1 1 8.8e-26 5.2e-22 77.9 0.0 42 154 1 107 1 107 0.97 BP28CT (NUC211) domain +PA28_alpha PF02251.11 64 jgi|Monbr1|1836|gw1.7.152.1 - 242 0.022 14.5 0.1 1 1 7.7e-06 0.046 13.5 0.0 22 48 196 221 190 236 0.89 Proteasome activator pa28 alpha subunit +Y_phosphatase PF00102.20 235 jgi|Monbr1|1850|gw1.5.238.1 - 246 2.5e-72 242.7 0.0 1 1 4.7e-76 2.8e-72 242.5 0.0 3 234 5 242 3 243 0.94 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|1850|gw1.5.238.1 - 246 0.00064 19.0 0.0 1 1 1.8e-07 0.0011 18.2 0.0 71 120 176 230 125 240 0.72 Dual specificity phosphatase, catalytic domain +Pkinase PF00069.18 260 jgi|Monbr1|1855|gw1.7.157.1 - 324 5e-57 192.7 0.0 1 1 3.9e-60 9.3e-57 191.8 0.0 1 260 15 310 15 310 0.91 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1855|gw1.7.157.1 - 324 8.6e-32 109.9 0.0 1 2 0.0036 8.5 5.0 0.0 4 38 18 48 15 58 0.77 Protein tyrosine kinase +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1855|gw1.7.157.1 - 324 8.6e-32 109.9 0.0 2 2 5e-33 1.2e-29 102.9 0.0 45 254 86 303 80 307 0.86 Protein tyrosine kinase +APH PF01636.16 238 jgi|Monbr1|1855|gw1.7.157.1 - 324 0.0031 16.9 0.0 1 2 5.5e-06 0.013 14.9 0.0 157 192 154 191 133 219 0.75 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|1855|gw1.7.157.1 - 324 0.0031 16.9 0.0 2 2 0.64 1.5e+03 -1.7 0.0 127 166 265 308 248 313 0.57 Phosphotransferase enzyme family +RIO1 PF01163.15 187 jgi|Monbr1|1855|gw1.7.157.1 - 324 0.028 13.4 0.0 1 1 2.1e-05 0.049 12.6 0.0 56 159 90 201 75 208 0.63 RIO1 family +Glyco_hydro_72 PF03198.7 315 jgi|Monbr1|1855|gw1.7.157.1 - 324 0.12 11.0 0.0 1 1 7.5e-05 0.18 10.4 0.0 57 112 90 146 76 166 0.80 Glycolipid anchored surface protein (GAS1) +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1858|gw1.7.158.1 - 137 6.8e-28 97.1 0.0 1 1 1.5e-31 8.9e-28 96.7 0.0 136 253 2 133 1 137 0.86 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|1858|gw1.7.158.1 - 137 5.7e-15 54.8 0.0 1 1 1.1e-18 6.5e-15 54.6 0.0 132 251 3 132 1 136 0.80 Protein kinase domain +TTL PF03133.8 294 jgi|Monbr1|1873|gw1.4.286.1 - 283 3.8e-55 186.5 0.0 1 1 6e-58 2.4e-54 183.9 0.0 13 264 3 281 1 283 0.86 Tubulin-tyrosine ligase family +ATP-grasp_3 PF02655.7 161 jgi|Monbr1|1873|gw1.4.286.1 - 283 0.002 17.6 0.0 1 2 2.5e-05 0.098 12.2 0.0 22 71 54 104 32 106 0.74 ATP-grasp domain +ATP-grasp_3 PF02655.7 161 jgi|Monbr1|1873|gw1.4.286.1 - 283 0.002 17.6 0.0 2 2 0.014 58 3.2 0.0 137 156 256 276 246 279 0.87 ATP-grasp domain +RimK PF08443.4 190 jgi|Monbr1|1873|gw1.4.286.1 - 283 0.019 14.1 0.0 1 2 0.0001 0.41 9.7 0.0 39 96 63 120 29 134 0.79 RimK-like ATP-grasp domain +RimK PF08443.4 190 jgi|Monbr1|1873|gw1.4.286.1 - 283 0.019 14.1 0.0 2 2 0.02 80 2.3 0.0 147 171 255 280 244 282 0.87 RimK-like ATP-grasp domain +Pkinase PF00069.18 260 jgi|Monbr1|1900|gw1.2.468.1 - 278 2.1e-69 233.3 0.0 1 1 7.8e-73 2.3e-69 233.1 0.0 1 253 4 278 4 278 0.95 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1900|gw1.2.468.1 - 278 4.1e-36 124.1 0.0 1 1 2.7e-39 8e-36 123.1 0.0 3 218 6 211 4 278 0.85 Protein tyrosine kinase +RIO1 PF01163.15 187 jgi|Monbr1|1900|gw1.2.468.1 - 278 0.0057 15.7 0.0 1 1 2.7e-06 0.0082 15.2 0.0 41 149 33 145 20 158 0.79 RIO1 family +APH PF01636.16 238 jgi|Monbr1|1900|gw1.2.468.1 - 278 0.025 13.9 0.9 1 2 0.14 4.1e+02 0.2 0.0 28 84 36 89 21 103 0.64 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|1900|gw1.2.468.1 - 278 0.025 13.9 0.9 2 2 4.4e-05 0.13 11.6 0.2 164 194 118 147 86 152 0.83 Phosphotransferase enzyme family +FtsJ PF01728.12 181 jgi|Monbr1|1907|gw1.4.288.1 - 181 2e-19 69.9 0.0 1 1 2.2e-23 2.7e-19 69.5 0.0 28 177 5 181 2 181 0.81 FtsJ-like methyltransferase +RhoGAP PF00620.20 153 jgi|Monbr1|1913|gw1.6.163.1 - 118 5e-23 81.1 0.0 1 1 4.8e-27 5.7e-23 80.8 0.0 53 150 1 98 1 102 0.97 RhoGAP domain +DnaJ PF00226.24 64 jgi|Monbr1|1919|gw1.8.216.1 - 258 1.1e-22 79.2 1.0 1 1 3.5e-26 2.1e-22 78.3 0.7 1 64 32 92 32 92 0.97 DnaJ domain +IncA PF04156.7 191 jgi|Monbr1|1919|gw1.8.216.1 - 258 0.08 12.2 0.0 1 3 2 1.2e+04 -5.7 2.0 41 56 1 15 1 16 0.54 IncA protein +IncA PF04156.7 191 jgi|Monbr1|1919|gw1.8.216.1 - 258 0.08 12.2 0.0 2 3 0.59 3.5e+03 -3.0 0.0 125 145 65 85 43 87 0.63 IncA protein +IncA PF04156.7 191 jgi|Monbr1|1919|gw1.8.216.1 - 258 0.08 12.2 0.0 3 3 1.3e-05 0.08 12.2 0.0 44 104 117 171 112 173 0.88 IncA protein +Mito_carr PF00153.20 96 jgi|Monbr1|1922|gw1.4.290.1 - 230 1.9e-54 181.0 0.9 1 3 1e-29 1.2e-25 88.6 0.0 8 94 1 97 1 99 0.97 Mitochondrial carrier protein +Mito_carr PF00153.20 96 jgi|Monbr1|1922|gw1.4.290.1 - 230 1.9e-54 181.0 0.9 2 3 1.8e-27 2.2e-23 81.4 0.0 3 92 104 192 102 195 0.95 Mitochondrial carrier protein +Mito_carr PF00153.20 96 jgi|Monbr1|1922|gw1.4.290.1 - 230 1.9e-54 181.0 0.9 3 3 9.6e-05 1.1 8.6 0.0 3 29 204 230 202 230 0.90 Mitochondrial carrier protein +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 1 8 0.0034 41 4.4 0.1 5 21 1 18 1 19 0.85 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 2 8 0.0017 20 5.4 0.0 5 18 25 38 21 42 0.80 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 3 8 0.02 2.3e+02 2.1 0.0 6 21 50 66 45 67 0.76 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 4 8 1.1e-06 0.013 15.0 0.0 2 20 70 89 69 91 0.87 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 5 8 0.00043 5.2 7.2 0.2 2 22 94 115 93 115 0.82 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 6 8 2.6e-05 0.31 10.9 0.0 2 21 118 138 117 139 0.88 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 7 8 0.00028 3.3 7.7 0.0 2 20 142 161 141 162 0.90 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|1925|gw1.6.166.1 - 174 1.3e-12 45.6 18.5 8 8 0.14 1.7e+03 -0.5 0.2 1 10 165 174 165 174 0.89 Leucine Rich Repeat +Pkinase PF00069.18 260 jgi|Monbr1|1938|gw1.7.164.1 - 205 4.7e-45 153.4 0.0 1 1 2.6e-48 5.2e-45 153.3 0.0 1 200 4 205 4 205 0.92 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|1938|gw1.7.164.1 - 205 5.9e-28 97.3 0.0 1 1 3.4e-31 6.8e-28 97.1 0.0 3 197 6 196 4 204 0.93 Protein tyrosine kinase +APH PF01636.16 238 jgi|Monbr1|1938|gw1.7.164.1 - 205 5e-07 29.3 3.2 1 2 2.3e-07 0.00047 19.6 0.2 4 108 9 121 8 123 0.81 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|1938|gw1.7.164.1 - 205 5e-07 29.3 3.2 2 2 7.3e-05 0.15 11.4 0.2 166 195 122 150 120 153 0.91 Phosphotransferase enzyme family +RIO1 PF01163.15 187 jgi|Monbr1|1938|gw1.7.164.1 - 205 5.7e-07 28.7 0.0 1 1 1.3e-09 2.7e-06 26.5 0.0 47 159 36 157 15 160 0.70 RIO1 family +Kdo PF06293.7 206 jgi|Monbr1|1938|gw1.7.164.1 - 205 0.0011 17.7 0.0 1 1 8.7e-07 0.0017 17.1 0.0 115 166 99 147 84 159 0.85 Lipopolysaccharide kinase (Kdo/WaaP) family +ABC1 PF03109.9 119 jgi|Monbr1|1938|gw1.7.164.1 - 205 0.061 12.9 0.4 1 1 5.2e-05 0.1 12.2 0.3 17 48 8 40 5 60 0.77 ABC1 family +SIR2 PF02146.10 181 jgi|Monbr1|1942|gw1.2.483.1 - 246 8.2e-58 194.7 0.0 1 1 1.6e-61 9.6e-58 194.5 0.0 1 181 19 210 19 210 0.96 Sir2 family +TPP_enzyme_M PF00205.15 137 jgi|Monbr1|1942|gw1.2.483.1 - 246 0.009 15.4 0.0 1 2 9.9e-05 0.59 9.5 0.0 2 26 2 26 1 33 0.87 Thiamine pyrophosphate enzyme, central domain +TPP_enzyme_M PF00205.15 137 jgi|Monbr1|1942|gw1.2.483.1 - 246 0.009 15.4 0.0 2 2 0.0056 34 3.8 0.0 74 92 192 210 182 240 0.74 Thiamine pyrophosphate enzyme, central domain +Glyco_transf_8 PF01501.13 242 jgi|Monbr1|1946|gw1.6.167.1 - 225 5.8e-43 146.6 0.0 1 1 1.4e-46 8.6e-43 146.0 0.0 2 238 6 219 5 222 0.96 Glycosyl transferase family 8 +Mannosyl_trans3 PF11051.1 265 jgi|Monbr1|1946|gw1.6.167.1 - 225 7.7e-05 21.8 0.0 1 1 1.6e-08 9.2e-05 21.5 0.0 79 129 84 132 5 149 0.71 Mannosyltransferase putative +tRNA_m1G_MT PF01746.14 186 jgi|Monbr1|1950|gw1.2.485.1 - 174 5.6e-39 133.3 0.0 1 1 1.3e-42 7.6e-39 132.9 0.0 3 186 10 171 8 171 0.91 tRNA (Guanine-1)-methyltransferase +Plectin PF00681.13 45 jgi|Monbr1|1950|gw1.2.485.1 - 174 0.048 12.8 0.0 1 1 1.7e-05 0.099 11.8 0.0 6 32 96 122 95 122 0.94 Plectin repeat +DUF1630 PF07792.5 584 jgi|Monbr1|1970|gw1.3.373.1 - 236 1.1e-50 172.2 0.3 1 2 1.6e-29 1.9e-25 88.8 0.0 255 344 1 103 1 124 0.89 Protein of unknown function (DUF1630) +DUF1630 PF07792.5 584 jgi|Monbr1|1970|gw1.3.373.1 - 236 1.1e-50 172.2 0.3 2 2 2.1e-27 2.5e-23 81.8 0.1 409 501 146 236 134 236 0.92 Protein of unknown function (DUF1630) +Peptidase_C1 PF00112.16 220 jgi|Monbr1|1982|gw1.7.171.1 - 294 3.1e-82 275.4 4.8 1 1 9.8e-86 3.9e-82 275.0 3.4 3 220 84 293 82 293 0.96 Papain family cysteine protease +Inhibitor_I29 PF08246.5 58 jgi|Monbr1|1982|gw1.7.171.1 - 294 1.2e-14 53.9 0.8 1 1 5.6e-18 2.2e-14 53.1 0.6 4 58 1 58 1 58 0.97 Cathepsin propeptide inhibitor domain (I29) +Peptidase_C1_2 PF03051.8 438 jgi|Monbr1|1982|gw1.7.171.1 - 294 0.02 13.1 2.6 1 2 0.0011 4.4 5.3 0.0 55 73 94 112 74 119 0.83 Peptidase C1-like family +Peptidase_C1_2 PF03051.8 438 jgi|Monbr1|1982|gw1.7.171.1 - 294 0.02 13.1 2.6 2 2 0.00025 1 7.5 0.4 378 398 254 274 239 278 0.86 Peptidase C1-like family +PPTA PF01239.15 31 jgi|Monbr1|1999|gw1.3.380.1 - 234 7.8e-40 132.2 20.3 1 5 1.9e-05 0.12 11.5 0.0 3 27 49 73 49 77 0.92 Protein prenyltransferase alpha subunit repeat +PPTA PF01239.15 31 jgi|Monbr1|1999|gw1.3.380.1 - 234 7.8e-40 132.2 20.3 2 5 2.3e-14 1.4e-10 39.7 0.7 2 28 88 114 87 115 0.95 Protein prenyltransferase alpha subunit repeat +PPTA PF01239.15 31 jgi|Monbr1|1999|gw1.3.380.1 - 234 7.8e-40 132.2 20.3 3 5 6.8e-13 4.1e-09 35.1 0.2 2 30 124 152 123 153 0.97 Protein prenyltransferase alpha subunit repeat +PPTA PF01239.15 31 jgi|Monbr1|1999|gw1.3.380.1 - 234 7.8e-40 132.2 20.3 4 5 3.5e-10 2.1e-06 26.5 1.0 2 30 161 189 160 190 0.93 Protein prenyltransferase alpha subunit repeat +PPTA PF01239.15 31 jgi|Monbr1|1999|gw1.3.380.1 - 234 7.8e-40 132.2 20.3 5 5 1.7e-11 1e-07 30.6 0.1 2 29 206 233 205 234 0.95 Protein prenyltransferase alpha subunit repeat +SWIRM PF04433.10 84 jgi|Monbr1|1999|gw1.3.380.1 - 234 0.21 11.3 1.7 1 2 0.00021 1.2 8.9 0.1 17 45 10 39 5 46 0.85 SWIRM domain +SWIRM PF04433.10 84 jgi|Monbr1|1999|gw1.3.380.1 - 234 0.21 11.3 1.7 2 2 0.06 3.6e+02 1.0 0.2 18 49 123 148 86 179 0.60 SWIRM domain +Kinesin PF00225.16 333 jgi|Monbr1|2025|gw1.5.252.1 - 298 7.3e-84 281.0 0.1 1 2 1.9e-31 2.2e-27 95.3 0.0 1 126 6 135 6 138 0.93 Kinesin motor domain +Kinesin PF00225.16 333 jgi|Monbr1|2025|gw1.5.252.1 - 298 7.3e-84 281.0 0.1 2 2 7.4e-58 8.8e-54 182.1 1.9 173 333 137 296 132 296 0.94 Kinesin motor domain +3HCDH_N PF02737.11 180 jgi|Monbr1|2035|gw1.2.507.1 - 253 1.1e-52 178.0 0.0 1 1 1.3e-55 1.3e-52 177.7 0.0 1 178 1 179 1 182 0.98 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain +3HCDH PF00725.15 97 jgi|Monbr1|2035|gw1.2.507.1 - 253 2.9e-18 65.7 0.0 1 1 5.5e-21 5.4e-18 64.8 0.0 1 69 184 251 184 253 0.94 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain +NAD_Gly3P_dh_N PF01210.16 159 jgi|Monbr1|2035|gw1.2.507.1 - 253 4.2e-07 29.4 0.1 1 1 9.9e-10 9.8e-07 28.2 0.0 2 107 1 118 1 148 0.77 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus +UDPG_MGDP_dh_N PF03721.7 185 jgi|Monbr1|2035|gw1.2.507.1 - 253 4.2e-05 22.6 0.0 1 1 6.2e-08 6.1e-05 22.1 0.0 2 80 1 83 1 135 0.78 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain +NAD_binding_2 PF03446.8 163 jgi|Monbr1|2035|gw1.2.507.1 - 253 7.5e-05 22.3 0.0 1 1 1.7e-07 0.00016 21.2 0.0 3 106 1 124 1 140 0.85 NAD binding domain of 6-phosphogluconate dehydrogenase +F420_oxidored PF03807.10 96 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.00083 19.4 0.1 1 2 2.2e-06 0.0022 18.0 0.0 1 81 1 77 1 87 0.91 NADP oxidoreductase coenzyme F420-dependent +F420_oxidored PF03807.10 96 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.00083 19.4 0.1 2 2 4.2 4.1e+03 -2.1 0.0 60 81 128 151 118 162 0.58 NADP oxidoreductase coenzyme F420-dependent +Pyr_redox PF00070.20 81 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.0067 16.4 0.0 1 1 1.2e-05 0.011 15.7 0.0 1 54 1 50 1 63 0.83 Pyridine nucleotide-disulphide oxidoreductase +AlaDh_PNT_C PF01262.14 168 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.0081 15.4 0.0 1 1 1.1e-05 0.011 14.9 0.0 22 70 1 49 1 88 0.83 Alanine dehydrogenase/PNT, C-terminal domain +ApbA PF02558.9 151 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.011 14.8 0.0 1 1 1.7e-05 0.017 14.2 0.0 1 37 2 39 2 60 0.87 Ketopantoate reductase PanE/ApbA +DAO PF01266.17 358 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.018 13.6 0.0 1 1 2.6e-05 0.025 13.1 0.0 2 40 2 42 1 80 0.80 FAD dependent oxidoreductase +TrkA_N PF02254.11 116 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.033 13.9 0.0 1 1 5.7e-05 0.057 13.1 0.0 1 41 2 42 2 73 0.84 TrkA-N domain +2-Hacid_dh_C PF02826.12 178 jgi|Monbr1|2035|gw1.2.507.1 - 253 0.12 11.2 0.0 1 1 0.00018 0.18 10.6 0.0 38 80 1 41 1 55 0.76 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain +Actin PF00022.12 381 jgi|Monbr1|2044|gw1.6.184.1 - 277 4.1e-35 120.6 0.0 1 1 4.6e-39 5.4e-35 120.2 0.0 88 372 1 277 1 277 0.87 Actin +Pkinase PF00069.18 260 jgi|Monbr1|2068|gw1.7.180.1 - 206 5.3e-58 195.9 0.0 1 1 1.5e-61 5.9e-58 195.7 0.0 1 200 3 205 3 206 0.97 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2068|gw1.7.180.1 - 206 5.2e-35 120.4 0.0 1 1 1.5e-38 6e-35 120.2 0.0 4 201 6 200 3 205 0.90 Protein tyrosine kinase +APH PF01636.16 238 jgi|Monbr1|2068|gw1.7.180.1 - 206 0.027 13.9 0.0 1 2 0.25 9.8e+02 -1.1 0.0 33 76 43 86 5 111 0.55 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|2068|gw1.7.180.1 - 206 0.027 13.9 0.0 2 2 2.4e-05 0.096 12.0 0.0 166 197 121 151 116 153 0.87 Phosphotransferase enzyme family +Y_phosphatase PF00102.20 235 jgi|Monbr1|2085|gw1.3.394.1 - 234 6.9e-70 234.7 0.2 1 1 1.3e-73 7.7e-70 234.6 0.2 5 229 1 234 1 234 0.97 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|2085|gw1.3.394.1 - 234 0.0012 18.1 0.0 1 1 3.4e-07 0.002 17.3 0.0 65 92 162 194 127 195 0.78 Dual specificity phosphatase, catalytic domain +Pkinase PF00069.18 260 jgi|Monbr1|2100|gw1.3.399.1 - 308 1.1e-60 204.7 0.0 1 1 7.9e-64 1.3e-60 204.4 0.0 2 255 8 291 7 294 0.93 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2100|gw1.3.399.1 - 308 4.8e-32 110.7 0.0 1 1 4.3e-34 7.3e-31 106.9 0.0 4 255 10 290 7 293 0.80 Protein tyrosine kinase +RIO1 PF01163.15 187 jgi|Monbr1|2100|gw1.3.399.1 - 308 0.0001 21.3 0.0 1 1 7.9e-08 0.00013 21.0 0.0 8 152 28 174 20 186 0.81 RIO1 family +APH PF01636.16 238 jgi|Monbr1|2100|gw1.3.399.1 - 308 0.00043 19.7 0.1 1 1 4.3e-07 0.00073 19.0 0.0 130 193 106 172 54 175 0.74 Phosphotransferase enzyme family +Kdo PF06293.7 206 jgi|Monbr1|2100|gw1.3.399.1 - 308 0.014 14.1 0.1 1 1 1.8e-05 0.03 13.0 0.1 122 165 130 170 111 175 0.84 Lipopolysaccharide kinase (Kdo/WaaP) family +essB PF10140.2 359 jgi|Monbr1|2100|gw1.3.399.1 - 308 0.041 12.1 0.0 1 1 3.2e-05 0.054 11.7 0.0 59 106 126 175 77 184 0.76 Predicted membrane protein essB +YrbL-PhoP_reg PF10707.2 199 jgi|Monbr1|2100|gw1.3.399.1 - 308 0.11 11.5 0.0 1 1 0.00012 0.2 10.6 0.0 123 154 131 162 109 170 0.77 PhoP regulatory network protein YrbL +zf-CCCH PF00642.17 27 jgi|Monbr1|2116|gw1.2.524.1 - 229 3.1e-09 36.0 2.7 1 2 1.3e-12 3.1e-09 36.0 1.8 1 26 96 121 96 122 0.92 Zinc finger C-x8-C-x5-C-x3-H type (and similar) +zf-CCCH PF00642.17 27 jgi|Monbr1|2116|gw1.2.524.1 - 229 3.1e-09 36.0 2.7 2 2 1.9 4.5e+03 -2.9 0.1 5 9 179 183 178 184 0.80 Zinc finger C-x8-C-x5-C-x3-H type (and similar) +zf-C3HC4 PF00097.18 42 jgi|Monbr1|2116|gw1.2.524.1 - 229 1.3e-06 27.8 10.3 1 2 1.9 4.5e+03 -2.7 0.1 3 10 100 107 99 117 0.65 Zinc finger, C3HC4 type (RING finger) +zf-C3HC4 PF00097.18 42 jgi|Monbr1|2116|gw1.2.524.1 - 229 1.3e-06 27.8 10.3 2 2 5.5e-10 1.3e-06 27.8 7.2 1 42 165 202 165 202 0.96 Zinc finger, C3HC4 type (RING finger) +zf-P11 PF03854.7 50 jgi|Monbr1|2116|gw1.2.524.1 - 229 0.00021 20.4 5.3 1 1 1.7e-07 0.0004 19.4 3.7 3 44 163 205 162 211 0.86 P-11 zinc finger +zf-Nse PF11789.1 57 jgi|Monbr1|2116|gw1.2.524.1 - 229 0.0035 16.5 6.8 1 1 2.6e-06 0.0063 15.7 4.7 9 56 160 202 155 203 0.85 Zinc-finger of the MIZ type in Nse subunit +Triabin PF03973.6 148 jgi|Monbr1|2116|gw1.2.524.1 - 229 0.28 10.5 2.4 1 2 0.0087 21 4.4 0.0 41 73 97 135 91 167 0.72 Triabin +Triabin PF03973.6 148 jgi|Monbr1|2116|gw1.2.524.1 - 229 0.28 10.5 2.4 2 2 0.0059 14 5.0 0.8 23 47 180 204 159 208 0.92 Triabin +2OG-FeII_Oxy PF03171.13 97 jgi|Monbr1|2133|gw1.5.270.1 - 302 1.2e-07 31.6 0.0 1 2 0.92 1.1e+04 -3.5 0.0 16 24 147 155 143 169 0.72 2OG-Fe(II) oxygenase superfamily +2OG-FeII_Oxy PF03171.13 97 jgi|Monbr1|2133|gw1.5.270.1 - 302 1.2e-07 31.6 0.0 2 2 2.3e-11 2.8e-07 30.5 0.0 12 97 201 302 175 302 0.78 2OG-Fe(II) oxygenase superfamily +UQ_con PF00179.19 140 jgi|Monbr1|2142|gw1.3.412.1 - 234 1.9e-41 140.4 0.0 1 1 3.9e-45 2.3e-41 140.1 0.0 2 136 11 160 10 164 0.91 Ubiquitin-conjugating enzyme +TFIIA PF03153.6 358 jgi|Monbr1|2142|gw1.3.412.1 - 234 0.17 11.5 4.8 1 1 3.1e-05 0.19 11.3 3.3 214 300 147 233 70 234 0.57 Transcription factor IIA, alpha/beta subunit +PAE PF03283.6 366 jgi|Monbr1|2156|gw1.4.320.1 - 265 6.2e-58 195.8 0.0 1 1 6.3e-62 7.4e-58 195.5 0.0 28 269 2 247 1 259 0.89 Pectinacetylesterase +Y_phosphatase PF00102.20 235 jgi|Monbr1|2175|gw1.4.323.1 - 212 1e-69 234.2 0.0 1 1 1.9e-73 1.1e-69 234.0 0.0 30 233 1 203 1 205 0.99 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|2175|gw1.4.323.1 - 212 0.0036 16.5 0.1 1 2 0.5 3e+03 -2.6 0.0 102 118 26 42 17 46 0.71 Dual specificity phosphatase, catalytic domain +DSPc PF00782.13 133 jgi|Monbr1|2175|gw1.4.323.1 - 212 0.0036 16.5 0.1 2 2 1.9e-06 0.011 14.9 0.1 62 91 127 157 59 161 0.67 Dual specificity phosphatase, catalytic domain +Lactamase_B PF00753.20 194 jgi|Monbr1|2176|gw1.8.237.1 - 224 6.8e-19 68.0 4.6 1 1 1.4e-22 8.3e-19 67.7 3.2 4 194 8 171 5 171 0.84 Metallo-beta-lactamase superfamily +Stathmin PF00836.12 140 jgi|Monbr1|2176|gw1.8.237.1 - 224 0.061 12.6 0.0 1 1 1.5e-05 0.09 12.1 0.0 43 76 187 220 174 222 0.91 Stathmin family +Abhydrolase_1 PF00561.13 231 jgi|Monbr1|2177|gw1.3.423.1 - 248 5.5e-16 58.4 0.1 1 1 1.2e-17 1.1e-14 54.1 0.1 2 228 29 247 28 248 0.80 alpha/beta hydrolase fold +Thioesterase PF00975.13 229 jgi|Monbr1|2177|gw1.3.423.1 - 248 8.2e-10 38.9 0.0 1 1 1e-12 9.2e-10 38.8 0.0 2 119 1 118 1 214 0.77 Thioesterase domain +PGAP1 PF07819.6 225 jgi|Monbr1|2177|gw1.3.423.1 - 248 9.1e-10 38.1 0.0 1 1 1.5e-12 1.4e-09 37.5 0.0 6 136 1 117 1 124 0.78 PGAP1-like protein +DUF676 PF05057.7 224 jgi|Monbr1|2177|gw1.3.423.1 - 248 4.4e-06 25.8 0.0 1 1 6.2e-09 5.7e-06 25.4 0.0 8 104 2 91 1 111 0.68 Putative serine esterase (DUF676) +Abhydrolase_3 PF07859.6 211 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.00016 21.0 0.1 1 1 2.7e-07 0.00025 20.3 0.0 2 108 3 103 2 194 0.70 alpha/beta hydrolase fold +Lipase_3 PF01764.18 143 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.00024 20.3 0.0 1 1 4.1e-07 0.00038 19.7 0.0 46 85 51 91 15 139 0.79 Lipase (class 3) +Esterase PF00756.13 252 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.00043 19.4 0.0 1 1 6.7e-07 0.00061 18.9 0.0 100 143 54 95 13 133 0.80 Putative esterase +DLH PF01738.11 217 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.0036 16.2 0.0 1 2 1.9e-05 0.018 14.0 0.0 17 122 2 92 1 99 0.79 Dienelactone hydrolase family +DLH PF01738.11 217 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.0036 16.2 0.0 2 2 4.4 4e+03 -3.5 0.0 137 164 188 215 186 233 0.69 Dienelactone hydrolase family +DUF1234 PF06821.6 171 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.0071 15.6 0.0 1 1 1.3e-05 0.012 14.9 0.0 47 97 60 108 37 130 0.67 Alpha/Beta hydrolase family of unknown function (DUF1234) +DUF2048 PF09752.2 349 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.0078 14.8 0.3 1 1 0.00014 0.13 10.8 0.2 241 328 44 234 2 248 0.60 Uncharacterized conserved protein (DUF2048) +Hydrolase_4 PF12146.1 79 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.016 14.7 0.0 1 1 3e-05 0.028 13.9 0.0 19 76 2 58 1 65 0.81 Putative lysophospholipase +DUF2974 PF11187.1 224 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.02 13.9 0.0 1 1 3.2e-05 0.029 13.4 0.0 75 110 60 94 43 140 0.78 Protein of unknown function (DUF2974) +PAF-AH_p_II PF03403.6 381 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.044 11.8 0.0 1 2 0.033 30 2.4 0.0 105 127 2 24 1 28 0.91 isoform II +PAF-AH_p_II PF03403.6 381 jgi|Monbr1|2177|gw1.3.423.1 - 248 0.044 11.8 0.0 2 2 0.00098 0.9 7.5 0.0 232 263 67 101 34 115 0.74 isoform II +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2178|gw1.2.535.1 - 278 9.1e-84 280.2 0.0 1 1 4.3e-87 1e-83 280.1 0.0 3 256 15 277 13 278 0.92 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2178|gw1.2.535.1 - 278 1.4e-46 158.4 0.0 1 1 7.1e-50 1.7e-46 158.1 0.0 5 254 17 276 14 278 0.88 Protein kinase domain +Kdo PF06293.7 206 jgi|Monbr1|2178|gw1.2.535.1 - 278 0.00011 21.0 0.0 1 1 6.7e-08 0.00016 20.4 0.0 57 165 67 166 59 183 0.83 Lipopolysaccharide kinase (Kdo/WaaP) family +APH PF01636.16 238 jgi|Monbr1|2178|gw1.2.535.1 - 278 0.03 13.7 0.0 1 1 2.6e-05 0.061 12.7 0.0 161 194 121 169 19 173 0.54 Phosphotransferase enzyme family +RIO1 PF01163.15 187 jgi|Monbr1|2178|gw1.2.535.1 - 278 0.087 11.8 0.0 1 1 5.4e-05 0.13 11.2 0.0 94 148 108 166 59 175 0.76 RIO1 family +EXS PF03124.7 346 jgi|Monbr1|2215|gw1.6.203.1 - 229 1.7e-73 247.3 7.2 1 1 4.8e-77 1.9e-73 247.1 5.0 130 345 2 222 1 223 0.96 EXS family +DUF805 PF05656.7 120 jgi|Monbr1|2215|gw1.6.203.1 - 229 0.027 13.9 2.5 1 1 2.2e-05 0.088 12.3 1.8 24 101 17 134 4 210 0.73 Protein of unknown function (DUF805) +DUF2919 PF11143.1 149 jgi|Monbr1|2215|gw1.6.203.1 - 229 0.047 13.2 0.1 1 1 2.5e-05 0.1 12.1 0.1 60 135 53 127 46 138 0.88 Protein of unknown function (DUF2919) +Pkinase PF00069.18 260 jgi|Monbr1|2234|gw1.8.245.1 - 247 5.8e-59 199.0 0.0 1 1 6.6e-62 1.6e-58 197.6 0.0 1 260 1 243 1 243 0.95 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2234|gw1.8.245.1 - 247 4.1e-28 97.9 0.0 1 1 1.6e-30 3.8e-27 94.7 0.0 4 256 4 238 1 240 0.88 Protein tyrosine kinase +Kdo PF06293.7 206 jgi|Monbr1|2234|gw1.8.245.1 - 247 0.015 14.0 0.1 1 1 1.2e-05 0.028 13.1 0.0 104 155 85 136 46 146 0.80 Lipopolysaccharide kinase (Kdo/WaaP) family +APH PF01636.16 238 jgi|Monbr1|2234|gw1.8.245.1 - 247 0.047 13.1 1.7 1 3 0.38 9e+02 -1.0 0.0 37 75 68 79 21 116 0.48 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|2234|gw1.8.245.1 - 247 0.047 13.1 1.7 2 3 2.9e-05 0.068 12.5 0.3 156 186 109 138 42 142 0.63 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|2234|gw1.8.245.1 - 247 0.047 13.1 1.7 3 3 0.82 1.9e+03 -2.1 0.0 98 98 199 199 143 244 0.46 Phosphotransferase enzyme family +FliT PF05400.6 109 jgi|Monbr1|2234|gw1.8.245.1 - 247 0.11 12.2 0.1 1 2 0.00028 0.68 9.6 0.0 66 99 40 74 12 83 0.79 Flagellar protein FliT +FliT PF05400.6 109 jgi|Monbr1|2234|gw1.8.245.1 - 247 0.11 12.2 0.1 2 2 0.26 6.1e+02 0.1 0.0 55 79 207 231 198 239 0.79 Flagellar protein FliT +HhH-GPD PF00730.18 121 jgi|Monbr1|2248|gw1.5.282.1 - 221 4.9e-18 65.2 0.0 1 1 1.8e-21 7e-18 64.7 0.0 1 106 47 167 47 180 0.92 HhH-GPD superfamily base excision DNA repair protein +EndIII_4Fe-2S PF10576.2 17 jgi|Monbr1|2248|gw1.5.282.1 - 221 6e-06 25.9 8.2 1 1 2.5e-09 9.7e-06 25.2 5.7 1 17 205 221 205 221 0.99 Iron-sulfur binding domain of endonuclease III +HHH PF00633.16 30 jgi|Monbr1|2248|gw1.5.282.1 - 221 0.0093 15.3 0.1 1 1 5.1e-06 0.02 14.2 0.1 17 30 128 141 128 141 0.93 Helix-hairpin-helix motif +IspD PF01128.12 221 jgi|Monbr1|2255|gw1.3.435.1 - 224 4.2e-44 150.3 0.0 1 1 1.2e-47 4.6e-44 150.2 0.0 1 219 1 223 1 224 0.94 Uncharacterized protein family UPF0007 +Nckap1 PF09735.2 1119 jgi|Monbr1|2255|gw1.3.435.1 - 224 0.057 10.5 0.0 1 1 1.9e-05 0.074 10.1 0.0 696 746 145 195 131 202 0.93 Membrane-associated apoptosis protein +DUF2249 PF10006.2 69 jgi|Monbr1|2255|gw1.3.435.1 - 224 0.11 11.8 0.0 1 2 0.0004 1.6 8.1 0.0 10 50 79 120 75 126 0.79 Uncharacterized conserved protein (DUF2249) +DUF2249 PF10006.2 69 jgi|Monbr1|2255|gw1.3.435.1 - 224 0.11 11.8 0.0 2 2 0.056 2.2e+02 1.2 0.0 42 66 188 211 186 214 0.80 Uncharacterized conserved protein (DUF2249) +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2266|gw1.2.562.1 - 192 2.3e-54 183.9 0.0 1 1 1.1e-57 2.5e-54 183.8 0.0 50 243 2 192 1 192 0.97 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2266|gw1.2.562.1 - 192 1.5e-51 174.7 0.0 1 1 7e-55 1.7e-51 174.6 0.0 47 242 2 192 1 192 0.95 Protein kinase domain +Kdo PF06293.7 206 jgi|Monbr1|2266|gw1.2.562.1 - 192 0.0011 17.7 0.2 1 1 6.2e-07 0.0015 17.3 0.2 93 166 29 100 15 112 0.82 Lipopolysaccharide kinase (Kdo/WaaP) family +APH PF01636.16 238 jgi|Monbr1|2266|gw1.2.562.1 - 192 0.014 14.8 0.2 1 2 1.2e-05 0.028 13.8 0.0 163 197 72 105 26 109 0.77 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|2266|gw1.2.562.1 - 192 0.014 14.8 0.2 2 2 0.81 1.9e+03 -2.0 0.0 55 108 123 169 112 185 0.58 Phosphotransferase enzyme family +RIO1 PF01163.15 187 jgi|Monbr1|2266|gw1.2.562.1 - 192 0.056 12.4 0.1 1 1 2.8e-05 0.067 12.2 0.1 80 156 27 107 1 112 0.69 RIO1 family +Y_phosphatase PF00102.20 235 jgi|Monbr1|2269|gw1.2.563.1 - 249 4.1e-73 245.3 0.0 1 1 7.8e-77 4.6e-73 245.1 0.0 1 234 10 246 10 247 0.96 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|2269|gw1.2.563.1 - 249 7.5e-06 25.2 0.0 1 1 2e-09 1.2e-05 24.6 0.0 56 129 163 243 131 246 0.73 Dual specificity phosphatase, catalytic domain +Pkinase PF00069.18 260 jgi|Monbr1|2270|gw1.3.436.1 - 196 5.5e-40 136.8 0.0 1 1 2e-43 6.1e-40 136.7 0.0 3 199 3 196 1 196 0.95 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2270|gw1.3.436.1 - 196 4.1e-22 78.2 0.0 1 1 1.6e-25 4.9e-22 77.9 0.0 3 199 3 190 2 196 0.89 Protein tyrosine kinase +APH PF01636.16 238 jgi|Monbr1|2270|gw1.3.436.1 - 196 0.0042 16.5 0.1 1 1 2.6e-06 0.0077 15.6 0.1 142 191 98 141 72 151 0.65 Phosphotransferase enzyme family +RIO1 PF01163.15 187 jgi|Monbr1|2270|gw1.3.436.1 - 196 0.0072 15.3 0.0 1 1 4.2e-06 0.013 14.5 0.0 79 159 67 152 34 156 0.71 RIO1 family +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2309|gw1.5.287.1 - 248 1.7e-73 246.6 0.0 1 1 3.1e-77 1.8e-73 246.5 0.0 6 255 1 248 1 248 0.96 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2309|gw1.5.287.1 - 248 2.7e-41 141.1 0.0 1 1 5.1e-45 3e-41 140.9 0.0 6 253 1 247 1 248 0.88 Protein kinase domain +Endonuclease_NS PF01223.16 204 jgi|Monbr1|2310|gw1.6.218.1 - 222 1.5e-51 174.6 0.0 1 1 1.5e-55 1.8e-51 174.4 0.0 4 199 15 219 13 222 0.97 DNA/RNA non-specific endonuclease +VSP PF03302.6 397 jgi|Monbr1|2316|gw1.4.339.1 - 241 1.2e-07 30.4 86.7 1 5 0.00025 1.5 7.0 3.2 109 134 2 27 1 31 0.71 Giardia variant-specific surface protein +VSP PF03302.6 397 jgi|Monbr1|2316|gw1.4.339.1 - 241 1.2e-07 30.4 86.7 2 5 2.9e-07 0.0017 16.7 14.7 89 159 30 100 27 104 0.89 Giardia variant-specific surface protein +VSP PF03302.6 397 jgi|Monbr1|2316|gw1.4.339.1 - 241 1.2e-07 30.4 86.7 3 5 5.2e-06 0.031 12.6 8.3 92 139 85 139 80 142 0.78 Giardia variant-specific surface protein +VSP PF03302.6 397 jgi|Monbr1|2316|gw1.4.339.1 - 241 1.2e-07 30.4 86.7 4 5 2.5e-05 0.15 10.3 8.5 92 138 139 184 135 190 0.75 Giardia variant-specific surface protein +VSP PF03302.6 397 jgi|Monbr1|2316|gw1.4.339.1 - 241 1.2e-07 30.4 86.7 5 5 0.00034 2 6.6 10.3 284 327 191 236 183 241 0.72 Giardia variant-specific surface protein +Furin-like PF00757.13 149 jgi|Monbr1|2316|gw1.4.339.1 - 241 0.00081 18.7 86.2 1 4 8e-06 0.047 13.0 8.6 50 95 2 49 1 51 0.83 Furin-like cysteine rich region +Furin-like PF00757.13 149 jgi|Monbr1|2316|gw1.4.339.1 - 241 0.00081 18.7 86.2 2 4 0.32 1.9e+03 -2.0 13.9 49 89 49 95 45 108 0.71 Furin-like cysteine rich region +Furin-like PF00757.13 149 jgi|Monbr1|2316|gw1.4.339.1 - 241 0.00081 18.7 86.2 3 4 0.0019 12 5.2 20.3 35 124 94 190 88 194 0.79 Furin-like cysteine rich region +Furin-like PF00757.13 149 jgi|Monbr1|2316|gw1.4.339.1 - 241 0.00081 18.7 86.2 4 4 4.4e-05 0.26 10.6 11.6 39 94 184 241 172 241 0.77 Furin-like cysteine rich region +Rad10 PF03834.7 69 jgi|Monbr1|2344|gw1.2.588.1 - 194 1.9e-25 88.0 0.0 1 1 1.5e-28 3.7e-25 87.1 0.0 5 67 1 63 1 65 0.95 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) +HHH PF00633.16 30 jgi|Monbr1|2344|gw1.2.588.1 - 194 0.0011 18.2 0.0 1 1 1.6e-06 0.0039 16.5 0.0 2 26 159 183 158 187 0.89 Helix-hairpin-helix motif +DUF2529 PF10740.2 172 jgi|Monbr1|2344|gw1.2.588.1 - 194 0.029 13.4 0.1 1 1 2.2e-05 0.053 12.6 0.0 37 101 102 166 91 173 0.87 Protein of unknown function (DUF2529) +HRDC PF00570.16 68 jgi|Monbr1|2344|gw1.2.588.1 - 194 0.037 13.4 0.0 1 2 0.98 2.3e+03 -2.0 0.0 20 32 83 95 74 96 0.67 HRDC domain +HRDC PF00570.16 68 jgi|Monbr1|2344|gw1.2.588.1 - 194 0.037 13.4 0.0 2 2 7.4e-05 0.18 11.2 0.0 34 59 158 183 154 188 0.87 HRDC domain +NUMOD1 PF07453.6 37 jgi|Monbr1|2344|gw1.2.588.1 - 194 0.52 9.9 2.5 1 2 0.0012 2.8 7.5 0.0 17 26 99 108 92 113 0.84 NUMOD1 domain +NUMOD1 PF07453.6 37 jgi|Monbr1|2344|gw1.2.588.1 - 194 0.52 9.9 2.5 2 2 0.12 2.9e+02 1.1 0.2 12 25 152 165 136 167 0.72 NUMOD1 domain +adh_short PF00106.18 167 jgi|Monbr1|2360|gw1.4.342.1 - 234 6.3e-25 87.6 1.9 1 1 2.2e-28 8.6e-25 87.2 1.3 3 166 6 174 4 175 0.89 short chain dehydrogenase +KR PF08659.3 181 jgi|Monbr1|2360|gw1.4.342.1 - 234 8.9e-12 44.7 2.5 1 2 3.2e-11 1.3e-07 31.1 0.1 3 92 6 93 5 111 0.84 KR domain +KR PF08659.3 181 jgi|Monbr1|2360|gw1.4.342.1 - 234 8.9e-12 44.7 2.5 2 2 7.1e-06 0.028 13.7 0.1 131 164 138 171 123 187 0.84 KR domain +DUF2177 PF09945.2 128 jgi|Monbr1|2360|gw1.4.342.1 - 234 0.19 11.4 1.1 1 1 7.6e-05 0.3 10.7 0.7 9 98 72 163 65 170 0.76 Predicted membrane protein (DUF2177) +Gly_transf_sug PF04488.8 105 jgi|Monbr1|2363|gw1.5.290.1 - 168 1.1e-11 44.7 0.0 1 1 1.4e-15 1.6e-11 44.1 0.0 1 92 16 96 16 106 0.86 Glycosyltransferase sugar-binding region containing DXD motif +Ribosomal_L18e PF00828.12 129 jgi|Monbr1|2372|gw1.2.598.1 - 180 1.4e-22 80.1 0.1 1 1 3.1e-26 1.8e-22 79.7 0.0 3 126 7 130 5 133 0.92 Ribosomal protein L18e/L15 +HasA PF06438.5 202 jgi|Monbr1|2372|gw1.2.598.1 - 180 0.061 12.3 0.0 1 1 1.3e-05 0.078 12.0 0.0 63 110 60 108 43 135 0.78 Heme-binding protein A (HasA) +dCMP_cyt_deam_2 PF08211.4 124 jgi|Monbr1|2378|gw1.6.226.1 - 248 4.5e-30 103.9 0.6 1 2 0.00013 0.53 9.9 0.1 43 95 8 62 2 74 0.87 Cytidine and deoxycytidylate deaminase zinc-binding region +dCMP_cyt_deam_2 PF08211.4 124 jgi|Monbr1|2378|gw1.6.226.1 - 248 4.5e-30 103.9 0.6 2 2 4e-30 1.6e-26 92.4 0.0 3 122 108 240 106 242 0.94 Cytidine and deoxycytidylate deaminase zinc-binding region +dCMP_cyt_deam_1 PF00383.15 102 jgi|Monbr1|2378|gw1.6.226.1 - 248 1.4e-18 66.0 1.2 1 2 3.2e-19 1.3e-15 56.5 0.2 17 93 11 88 1 93 0.84 Cytidine and deoxycytidylate deaminase zinc-binding region +dCMP_cyt_deam_1 PF00383.15 102 jgi|Monbr1|2378|gw1.6.226.1 - 248 1.4e-18 66.0 1.2 2 2 0.00029 1.1 8.5 0.0 5 78 152 224 149 234 0.81 Cytidine and deoxycytidylate deaminase zinc-binding region +Mg_chelatase PF01078.14 207 jgi|Monbr1|2378|gw1.6.226.1 - 248 0.0031 16.3 0.5 1 2 0.00014 0.54 9.0 0.0 97 166 19 83 8 94 0.85 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|2378|gw1.6.226.1 - 248 0.0031 16.3 0.5 2 2 0.0019 7.7 5.3 0.0 14 33 130 149 122 162 0.87 Magnesium chelatase, subunit ChlI +HhH-GPD PF00730.18 121 jgi|Monbr1|2386|gw1.2.604.1 - 224 2.3e-21 75.9 0.0 1 1 1e-24 3e-21 75.5 0.0 1 119 47 185 47 187 0.94 HhH-GPD superfamily base excision DNA repair protein +HHH PF00633.16 30 jgi|Monbr1|2386|gw1.2.604.1 - 224 1.9e-08 33.2 0.0 1 2 0.52 1.6e+03 -1.2 0.0 13 18 67 72 56 72 0.79 Helix-hairpin-helix motif +HHH PF00633.16 30 jgi|Monbr1|2386|gw1.2.604.1 - 224 1.9e-08 33.2 0.0 2 2 3.6e-11 1.1e-07 30.8 0.0 2 25 115 138 114 141 0.95 Helix-hairpin-helix motif +DNA_binding_1 PF01035.13 85 jgi|Monbr1|2386|gw1.2.604.1 - 224 0.11 11.9 0.2 1 1 6.4e-05 0.19 11.1 0.1 30 58 131 162 120 183 0.78 6-O-methylguanine DNA methyltransferase, DNA binding domain +EndIII_4Fe-2S PF10576.2 17 jgi|Monbr1|2386|gw1.2.604.1 - 224 0.16 11.9 5.5 1 1 0.00011 0.31 10.9 3.8 1 17 205 221 205 221 0.98 Iron-sulfur binding domain of endonuclease III +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2396|gw1.6.234.1 - 157 6.7e-27 93.9 0.0 1 1 1.9e-30 7.6e-27 93.7 0.0 5 151 10 155 6 157 0.91 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2396|gw1.6.234.1 - 157 3.1e-25 88.4 0.0 1 1 8.7e-29 3.5e-25 88.3 0.0 7 144 12 153 6 157 0.87 Protein kinase domain +APH PF01636.16 238 jgi|Monbr1|2396|gw1.6.234.1 - 157 0.00072 19.0 0.2 1 2 0.00089 3.5 6.9 0.0 24 108 34 126 8 129 0.81 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|2396|gw1.6.234.1 - 157 0.00072 19.0 0.2 2 2 4.7e-05 0.19 11.1 0.0 168 192 129 152 125 157 0.80 Phosphotransferase enzyme family +RRM_1 PF00076.15 70 jgi|Monbr1|2423|gw1.4.348.1 - 159 3e-37 125.7 0.1 1 2 9.3e-21 3.7e-17 61.4 0.0 1 60 2 60 2 71 0.90 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +RRM_1 PF00076.15 70 jgi|Monbr1|2423|gw1.4.348.1 - 159 3e-37 125.7 0.1 2 2 3.3e-21 1.3e-17 62.8 0.0 1 68 91 158 91 159 0.94 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +NID PF07292.6 88 jgi|Monbr1|2423|gw1.4.348.1 - 159 0.0018 17.9 0.0 1 2 0.0017 6.7 6.5 0.0 2 23 45 66 44 76 0.88 Nmi/IFP 35 domain (NID) +NID PF07292.6 88 jgi|Monbr1|2423|gw1.4.348.1 - 159 0.0018 17.9 0.0 2 2 0.00024 0.95 9.2 0.0 2 23 134 155 133 159 0.92 Nmi/IFP 35 domain (NID) +RRM_3 PF08777.4 105 jgi|Monbr1|2423|gw1.4.348.1 - 159 0.055 13.0 0.0 1 2 0.11 4.2e+02 0.5 0.0 7 28 5 26 2 35 0.85 RNA binding motif +RRM_3 PF08777.4 105 jgi|Monbr1|2423|gw1.4.348.1 - 159 0.055 13.0 0.0 2 2 0.00016 0.63 9.6 0.0 6 60 93 153 90 159 0.77 RNA binding motif +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2432|gw1.3.464.1 - 263 1.5e-77 259.8 0.0 1 1 2.9e-81 1.7e-77 259.7 0.0 2 255 8 262 7 263 0.95 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2432|gw1.3.464.1 - 263 3.2e-39 134.3 0.0 1 1 5.9e-43 3.5e-39 134.2 0.0 3 253 9 261 7 263 0.88 Protein kinase domain +Y_phosphatase PF00102.20 235 jgi|Monbr1|2433|gw1.7.211.1 - 207 4e-62 209.3 0.0 1 1 7.4e-66 4.4e-62 209.2 0.0 28 228 3 206 1 207 0.96 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|2433|gw1.7.211.1 - 207 0.00021 20.5 0.0 1 1 4.8e-08 0.00029 20.1 0.0 70 99 145 174 78 206 0.72 Dual specificity phosphatase, catalytic domain +DPRP PF04244.6 224 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.12 11.5 5.8 1 2 1.2e-05 0.036 13.2 0.7 56 126 96 166 93 188 0.87 Deoxyribodipyrimidine photo-lyase-related protein +DPRP PF04244.6 224 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.12 11.5 5.8 2 2 0.13 4e+02 -0.0 0.2 7 41 194 228 190 237 0.67 Deoxyribodipyrimidine photo-lyase-related protein +IncA PF04156.7 191 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.37 10.0 39.0 1 2 0.00076 2.3 7.4 10.6 77 168 30 124 2 138 0.84 IncA protein +IncA PF04156.7 191 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.37 10.0 39.0 2 2 0.00039 1.1 8.4 10.9 81 179 147 243 128 245 0.68 IncA protein +DUF910 PF06014.4 62 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.5 10.0 6.6 1 4 0.00058 1.7 8.2 0.1 21 45 65 90 63 94 0.82 Bacterial protein of unknown function (DUF910) +DUF910 PF06014.4 62 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.5 10.0 6.6 2 4 0.68 2e+03 -1.6 0.0 46 57 175 186 167 188 0.71 Bacterial protein of unknown function (DUF910) +DUF910 PF06014.4 62 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.5 10.0 6.6 3 4 0.16 4.9e+02 0.4 0.1 20 45 203 227 199 233 0.78 Bacterial protein of unknown function (DUF910) +DUF910 PF06014.4 62 jgi|Monbr1|2444|gw1.7.212.1 - 245 0.5 10.0 6.6 4 4 0.034 1e+02 2.6 0.1 20 38 224 242 220 244 0.84 Bacterial protein of unknown function (DUF910) +Tmemb_cc2 PF10267.2 395 jgi|Monbr1|2444|gw1.7.212.1 - 245 1.3 7.1 21.6 1 2 1.4e-05 0.041 12.1 3.9 198 274 55 130 46 135 0.85 Predicted transmembrane and coiled-coil 2 protein +Tmemb_cc2 PF10267.2 395 jgi|Monbr1|2444|gw1.7.212.1 - 245 1.3 7.1 21.6 2 2 0.031 91 1.1 5.4 220 270 191 241 153 245 0.74 Predicted transmembrane and coiled-coil 2 protein +AAA PF00004.22 130 jgi|Monbr1|2458|gw1.5.298.1 - 168 2.1e-13 50.3 0.0 1 1 3.7e-16 2.3e-13 50.1 0.0 1 91 2 84 2 144 0.78 ATPase family associated with various cellular activities (AAA) +AAA_5 PF07728.7 139 jgi|Monbr1|2458|gw1.5.298.1 - 168 2.8e-10 39.7 0.0 1 1 6.4e-13 4e-10 39.2 0.0 2 97 2 92 1 102 0.90 AAA domain (dynein-related subfamily) +RuvB_N PF05496.5 234 jgi|Monbr1|2458|gw1.5.298.1 - 168 9.9e-06 24.4 0.0 1 1 1.9e-08 1.2e-05 24.1 0.0 53 76 2 25 1 84 0.77 Holliday junction DNA helicase ruvB N-terminus +DUF265 PF03266.8 168 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.00036 19.9 0.1 1 2 5.1e-06 0.0032 16.8 0.0 2 28 2 28 1 33 0.83 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.00036 19.9 0.1 2 2 0.31 1.9e+02 1.3 0.0 87 129 53 95 29 106 0.66 Protein of unknown function, DUF265 +AAA_3 PF07726.4 131 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.00042 19.6 0.0 1 1 9.5e-07 0.00059 19.1 0.0 2 87 2 85 1 96 0.81 ATPase family associated with various cellular activities (AAA) +SRP54 PF00448.15 196 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.00059 19.0 0.0 1 1 1.3e-06 0.00083 18.5 0.0 3 94 1 89 1 95 0.80 SRP54-type protein, GTPase domain +Viral_helicase1 PF01443.11 226 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.00086 18.6 0.0 1 1 1.9e-06 0.0012 18.2 0.0 3 83 4 85 2 87 0.71 Viral (Superfamily 1) RNA helicase +Zeta_toxin PF06414.5 201 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.0011 17.7 0.0 1 1 2.4e-06 0.0015 17.3 0.0 18 52 1 34 1 56 0.89 Zeta toxin +RNA_helicase PF00910.15 107 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.0026 17.5 0.0 1 1 6.9e-06 0.0043 16.9 0.0 1 77 2 84 2 91 0.79 RNA helicase +AAA_2 PF07724.7 171 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.0037 16.8 0.0 1 1 7.9e-06 0.005 16.4 0.0 6 105 2 86 1 92 0.82 AAA domain (Cdc48 subfamily) +NACHT PF05729.5 166 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.0051 16.1 0.0 1 2 2.6e-05 0.016 14.5 0.0 2 24 1 23 1 34 0.87 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.0051 16.1 0.0 2 2 1.1 6.7e+02 -0.6 0.0 84 95 55 74 26 121 0.66 NACHT domain +IstB PF01695.10 178 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.0058 15.7 0.1 1 1 1.3e-05 0.0084 15.2 0.1 50 77 2 29 1 91 0.71 IstB-like ATP binding protein +Rad17 PF03215.8 498 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.013 14.0 0.0 1 1 2.5e-05 0.016 13.7 0.0 47 80 1 33 1 79 0.81 Rad17 cell cycle checkpoint protein +DUF258 PF03193.9 161 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.032 13.1 0.0 1 1 6.9e-05 0.043 12.6 0.0 38 72 2 36 1 100 0.88 Protein of unknown function, DUF258 +NB-ARC PF00931.15 285 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.046 12.2 0.0 1 1 0.0001 0.064 11.7 0.0 21 42 1 22 1 31 0.87 NB-ARC domain +Mg_chelatase PF01078.14 207 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.056 12.2 0.0 1 1 0.00018 0.12 11.2 0.0 25 42 2 19 1 33 0.90 Magnesium chelatase, subunit ChlI +TIP49 PF06068.6 398 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.062 11.6 0.0 1 1 0.00012 0.077 11.3 0.0 53 76 2 25 1 56 0.81 TIP49 C-terminus +MobB PF03205.7 137 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.12 11.8 0.0 1 1 0.0003 0.19 11.2 0.0 2 24 1 23 1 53 0.89 Molybdopterin guanine dinucleotide synthesis protein B +PhoH PF02562.9 205 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.13 11.1 0.4 1 2 0.0022 1.4 7.8 0.1 21 42 1 22 1 30 0.87 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|2458|gw1.5.298.1 - 168 0.13 11.1 0.4 2 2 0.13 82 2.0 0.0 93 139 34 80 21 89 0.82 PhoH-like protein +CH PF00307.24 109 jgi|Monbr1|2477|gw1.3.472.1 - 183 1.3e-06 27.9 0.0 1 1 1.6e-10 1.9e-06 27.4 0.0 9 106 31 137 20 139 0.77 Calponin homology (CH) domain +Methyltransf_15 PF09445.3 164 jgi|Monbr1|2498|gw1.2.631.1 - 205 2.3e-36 124.5 0.0 1 1 2.1e-39 2.7e-36 124.2 0.0 3 162 46 203 44 205 0.91 RNA cap guanine-N2 methyltransferase +UPF0020 PF01170.11 171 jgi|Monbr1|2498|gw1.2.631.1 - 205 2.1e-11 43.2 0.0 1 1 2.1e-14 2.7e-11 42.9 0.0 28 109 43 128 31 158 0.89 Putative RNA methylase family UPF0020 +Methyltransf_3 PF01596.10 205 jgi|Monbr1|2498|gw1.2.631.1 - 205 3.7e-06 25.8 0.0 1 1 3.9e-09 5.1e-06 25.3 0.0 60 127 56 122 34 136 0.86 O-methyltransferase +Cons_hypoth95 PF03602.8 183 jgi|Monbr1|2498|gw1.2.631.1 - 205 6.2e-06 25.4 0.0 1 1 7.2e-09 9.5e-06 24.8 0.0 43 129 44 131 32 145 0.86 Conserved hypothetical protein 95 +PrmA PF06325.6 295 jgi|Monbr1|2498|gw1.2.631.1 - 205 3.6e-05 22.7 0.3 1 1 3.7e-08 4.9e-05 22.2 0.2 162 218 44 98 31 119 0.84 Ribosomal protein L11 methyltransferase (PrmA) +Met_10 PF02475.9 200 jgi|Monbr1|2498|gw1.2.631.1 - 205 3.8e-05 23.0 0.0 1 1 3.1e-08 4.1e-05 22.9 0.0 100 168 42 108 33 203 0.85 Met-10+ like-protein +DUF548 PF04445.6 235 jgi|Monbr1|2498|gw1.2.631.1 - 205 0.00014 20.7 0.0 1 1 1.4e-07 0.00019 20.3 0.0 57 161 24 126 9 151 0.83 Protein of unknown function (DUF548) +Methyltransf_11 PF08241.5 95 jgi|Monbr1|2498|gw1.2.631.1 - 205 0.0002 21.4 0.0 1 1 2.8e-07 0.00037 20.5 0.0 5 53 52 103 48 124 0.80 Methyltransferase domain +Methyltransf_12 PF08242.5 99 jgi|Monbr1|2498|gw1.2.631.1 - 205 0.093 12.9 0.0 1 1 0.00011 0.14 12.3 0.0 5 71 52 121 48 161 0.74 Methyltransferase domain +RhoGAP PF00620.20 153 jgi|Monbr1|2505|gw1.5.301.1 - 182 4.6e-41 139.6 0.0 1 1 4.5e-45 5.3e-41 139.4 0.0 1 150 1 153 1 157 0.97 RhoGAP domain +MIP PF00230.13 227 jgi|Monbr1|2529|gw1.2.644.1 - 213 5.7e-52 176.1 12.6 1 1 1.6e-55 6.4e-52 175.9 8.8 8 227 1 213 1 213 0.95 Major intrinsic protein +Xan_ur_permease PF00860.13 389 jgi|Monbr1|2529|gw1.2.644.1 - 213 0.12 10.4 4.0 1 1 3.4e-05 0.14 10.3 2.8 42 199 3 168 1 201 0.82 Permease family +Competence PF03772.9 271 jgi|Monbr1|2529|gw1.2.644.1 - 213 0.96 8.1 4.0 1 2 0.00012 0.47 9.1 0.8 8 61 34 85 27 103 0.69 Competence protein +Competence PF03772.9 271 jgi|Monbr1|2529|gw1.2.644.1 - 213 0.96 8.1 4.0 2 2 0.18 7.3e+02 -1.4 0.0 59 72 153 166 125 194 0.54 Competence protein +Kinesin PF00225.16 333 jgi|Monbr1|2537|gw1.2.645.1 - 242 1.5e-64 217.5 0.0 1 1 2.9e-68 1.7e-64 217.3 0.0 101 333 1 236 1 236 0.94 Kinesin motor domain +HET-s_218-289 PF11558.1 72 jgi|Monbr1|2537|gw1.2.645.1 - 242 0.025 14.1 0.0 1 1 8.4e-06 0.05 13.1 0.0 14 53 117 163 108 169 0.78 Het-s 218-289 +DUF3595 PF12166.1 422 jgi|Monbr1|2538|gw1.4.369.1 - 220 2e-22 79.2 0.0 1 1 2.4e-26 2.8e-22 78.8 0.0 1 113 103 219 103 220 0.93 Protein of unknown function (DUF3595) +SSrecog PF03531.7 216 jgi|Monbr1|2543|gw1.7.222.1 - 175 6e-11 41.6 0.4 1 2 0.13 8e+02 -1.3 0.0 55 77 52 74 24 85 0.67 Structure-specific recognition protein (SSRP1) +SSrecog PF03531.7 216 jgi|Monbr1|2543|gw1.7.222.1 - 175 6e-11 41.6 0.4 2 2 2.4e-14 1.4e-10 40.4 0.1 2 48 129 174 128 175 0.89 Structure-specific recognition protein (SSRP1) +DUF2126 PF09899.2 819 jgi|Monbr1|2543|gw1.7.222.1 - 175 0.097 10.3 0.0 1 1 1.9e-05 0.11 10.1 0.0 221 288 9 77 5 128 0.70 Putative amidoligase enzyme (DUF2126) +Sulfatase PF00884.16 379 jgi|Monbr1|2548|gw1.2.649.1 - 241 2.3e-37 128.5 0.1 1 1 6.6e-41 2.6e-37 128.4 0.1 100 329 1 239 1 241 0.89 Sulfatase +DUF229 PF02995.10 499 jgi|Monbr1|2548|gw1.2.649.1 - 241 0.017 13.3 0.0 1 1 4.4e-06 0.018 13.2 0.0 307 346 116 155 66 194 0.86 Protein of unknown function (DUF229) +Phosphodiest PF01663.15 364 jgi|Monbr1|2548|gw1.2.649.1 - 241 0.029 13.4 0.0 1 1 1e-05 0.041 12.9 0.0 210 243 121 154 73 155 0.87 Type I phosphodiesterase / nucleotide pyrophosphatase +PAPS_reduct PF01507.12 174 jgi|Monbr1|2558|gw1.3.487.1 - 239 1.7e-37 128.5 0.0 1 1 1.7e-41 2.1e-37 128.3 0.0 2 174 36 209 35 209 0.98 Phosphoadenosine phosphosulfate reductase family +Cupin_4 PF08007.5 319 jgi|Monbr1|2560|gw1.2.653.1 - 217 4e-10 39.0 0.2 1 1 1.2e-13 4.9e-10 38.8 0.1 111 207 103 215 72 217 0.79 Cupin superfamily protein +JmjC PF02373.15 114 jgi|Monbr1|2560|gw1.2.653.1 - 217 1.4e-06 28.2 0.0 1 1 1e-09 4e-06 26.7 0.0 73 114 177 217 112 217 0.85 JmjC domain +Cupin_2 PF07883.4 71 jgi|Monbr1|2560|gw1.2.653.1 - 217 0.015 14.4 0.0 1 1 7.6e-06 0.03 13.4 0.0 39 62 186 209 179 216 0.87 Cupin domain +DUF3595 PF12166.1 422 jgi|Monbr1|2570|gw1.4.376.1 - 237 2.8e-38 131.5 0.1 1 1 1.3e-41 3.8e-38 131.0 0.1 2 124 105 227 104 236 0.94 Protein of unknown function (DUF3595) +Per1 PF04080.6 267 jgi|Monbr1|2570|gw1.4.376.1 - 237 0.0076 15.3 2.1 1 1 6.4e-06 0.019 14.0 1.5 112 246 16 223 9 229 0.81 Per1-like +7tm_1 PF00001.14 255 jgi|Monbr1|2570|gw1.4.376.1 - 237 0.48 9.2 6.6 1 1 0.013 38 2.9 4.6 186 230 132 198 3 212 0.57 7 transmembrane receptor (rhodopsin family) +BPD_transp_2 PF02653.9 267 jgi|Monbr1|2570|gw1.4.376.1 - 237 1.5 7.4 4.9 1 1 0.00066 2 7.0 3.4 57 148 28 185 3 188 0.78 Branched-chain amino acid transport system / permease component +Lactamase_B PF00753.20 194 jgi|Monbr1|2631|gw1.2.671.1 - 194 8.1e-05 22.0 4.6 1 1 5.7e-08 0.00068 19.0 3.2 48 147 20 108 15 118 0.88 Metallo-beta-lactamase superfamily +GDA1_CD39 PF01150.10 436 jgi|Monbr1|2652|gw1.2.677.1 - 162 7.7e-53 179.2 0.0 1 1 2.1e-56 8.5e-53 179.0 0.0 10 179 2 162 1 162 0.94 GDA1/CD39 (nucleoside phosphatase) family +Ppx-GppA PF02541.9 285 jgi|Monbr1|2652|gw1.2.677.1 - 162 0.004 16.0 0.0 1 1 1.2e-06 0.0047 15.8 0.0 87 126 118 162 72 162 0.71 Ppx/GppA phosphatase family +DUF1028 PF06267.5 190 jgi|Monbr1|2652|gw1.2.677.1 - 162 0.023 13.8 0.0 1 1 8.5e-06 0.034 13.2 0.0 46 91 114 159 111 162 0.89 Family of unknown function (DUF1028) +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2660|gw1.4.388.1 - 215 2.7e-59 200.0 0.0 1 1 5e-63 3e-59 199.9 0.0 48 258 1 214 1 215 0.96 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2660|gw1.4.388.1 - 215 1.2e-30 106.2 0.0 1 1 2.2e-34 1.3e-30 106.1 0.0 47 256 3 213 1 215 0.88 Protein kinase domain +VHS PF00790.12 141 jgi|Monbr1|2665|gw1.4.390.1 - 212 3.7e-32 110.5 7.6 1 2 9e-35 1.3e-31 108.7 1.6 9 141 3 131 1 131 0.95 VHS domain +VHS PF00790.12 141 jgi|Monbr1|2665|gw1.4.390.1 - 212 3.7e-32 110.5 7.6 2 2 0.009 13 5.0 0.2 72 86 176 190 167 193 0.89 VHS domain +FYVE PF01363.14 69 jgi|Monbr1|2665|gw1.4.390.1 - 212 8.4e-18 63.7 9.9 1 2 0.41 6.1e+02 0.1 0.0 32 53 74 92 66 125 0.73 FYVE zinc finger +FYVE PF01363.14 69 jgi|Monbr1|2665|gw1.4.390.1 - 212 8.4e-18 63.7 9.9 2 2 5.6e-21 8.4e-18 63.7 6.9 2 66 152 211 151 212 0.94 FYVE zinc finger +Ipi1_N PF12333.1 102 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.0041 16.7 0.0 1 2 2.6e-05 0.039 13.6 0.0 16 65 42 92 36 102 0.81 Rix1 complex component involved in 60S ribosome maturation +Ipi1_N PF12333.1 102 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.0041 16.7 0.0 2 2 0.15 2.3e+02 1.5 0.0 25 45 94 114 93 127 0.83 Rix1 complex component involved in 60S ribosome maturation +Adaptin_N PF01602.13 536 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.0043 15.1 0.8 1 1 3.7e-06 0.0055 14.7 0.5 258 337 18 103 4 105 0.87 Adaptin N terminal region +IBR PF01485.14 64 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.011 15.3 4.4 1 1 2e-05 0.03 13.8 3.0 18 57 156 189 141 194 0.79 IBR domain +DUF3361 PF11841.1 160 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.016 14.5 0.2 1 1 1.5e-05 0.023 14.1 0.1 70 127 47 105 25 130 0.83 Domain of unknown function (DUF3361) +C1_1 PF00130.15 53 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.37 10.2 8.3 1 2 0.0001 0.15 11.4 3.5 9 45 154 189 146 194 0.89 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|2665|gw1.4.390.1 - 212 0.37 10.2 8.3 2 2 2.6 3.9e+03 -2.7 0.0 28 34 202 208 196 211 0.58 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_4 PF07975.5 51 jgi|Monbr1|2665|gw1.4.390.1 - 212 1.1 9.0 9.4 1 2 1.4 2e+03 -1.5 0.0 4 18 80 94 78 120 0.62 TFIIH C1-like domain +C1_4 PF07975.5 51 jgi|Monbr1|2665|gw1.4.390.1 - 212 1.1 9.0 9.4 2 2 0.00097 1.4 8.6 5.2 1 35 158 186 158 187 0.90 TFIIH C1-like domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2692|gw1.2.689.1 - 192 3.9e-45 153.6 0.0 1 1 7.2e-49 4.3e-45 153.5 0.0 60 251 1 192 1 192 0.97 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|2692|gw1.2.689.1 - 192 3.9e-19 68.5 0.0 1 1 7.5e-23 4.5e-19 68.3 0.0 73 250 17 192 1 192 0.84 Protein kinase domain +Ank PF00023.23 33 jgi|Monbr1|2701|gw1.3.509.1 - 173 1.4e-28 96.9 8.1 1 4 1.4e-09 5.6e-06 25.5 0.0 2 32 1 31 1 32 0.97 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2701|gw1.3.509.1 - 173 1.4e-28 96.9 8.1 2 4 0.00074 2.9 7.5 0.0 1 22 33 54 33 58 0.84 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2701|gw1.3.509.1 - 173 1.4e-28 96.9 8.1 3 4 2e-11 8.1e-08 31.4 0.7 2 33 102 133 101 133 0.96 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2701|gw1.3.509.1 - 173 1.4e-28 96.9 8.1 4 4 2e-12 8e-09 34.5 0.2 1 33 134 166 134 166 0.96 Ankyrin repeat +TAFH PF07531.7 97 jgi|Monbr1|2701|gw1.3.509.1 - 173 0.062 12.6 0.0 1 1 2.8e-05 0.11 11.8 0.0 24 70 11 57 6 67 0.92 NHR1 homology to TAF +FAD_binding_2 PF00890.17 421 jgi|Monbr1|2701|gw1.3.509.1 - 173 0.12 10.9 1.7 1 1 4.2e-05 0.17 10.4 1.2 14 91 81 160 79 163 0.87 FAD binding domain +Ank PF00023.23 33 jgi|Monbr1|2715|gw1.6.271.1 - 127 1.5e-21 74.7 1.5 1 4 1.5e-05 0.17 11.4 0.1 2 24 2 24 1 32 0.88 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2715|gw1.6.271.1 - 127 1.5e-21 74.7 1.5 2 4 3.5e-09 4.1e-05 22.8 0.0 1 23 34 57 34 72 0.93 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2715|gw1.6.271.1 - 127 1.5e-21 74.7 1.5 3 4 5.7e-13 6.8e-09 34.7 0.0 2 32 77 107 76 108 0.91 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2715|gw1.6.271.1 - 127 1.5e-21 74.7 1.5 4 4 0.012 1.4e+02 2.2 0.0 2 9 110 117 109 122 0.83 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2724|gw1.4.402.1 - 159 2.8e-24 83.3 2.9 1 3 9.2e-13 1.1e-08 34.1 0.1 3 32 1 30 1 31 0.97 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2724|gw1.4.402.1 - 159 2.8e-24 83.3 2.9 2 3 1.8e-11 2.2e-07 30.0 0.1 1 32 67 98 67 99 0.97 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|2724|gw1.4.402.1 - 159 2.8e-24 83.3 2.9 3 3 1.2e-07 0.0014 17.9 0.0 2 32 101 131 100 132 0.91 Ankyrin repeat +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 1 7 2.5e-06 0.015 15.1 7.6 1 32 1 28 1 28 0.91 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 2 7 2.6e-07 0.0015 18.2 7.8 1 32 28 54 28 54 0.92 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 3 7 7e-08 0.00041 20.1 9.3 1 32 59 90 59 90 0.91 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 4 7 1.7e-06 0.01 15.6 11.1 1 32 101 127 95 127 0.88 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 5 7 2.4e-09 1.4e-05 24.8 8.5 1 32 132 163 132 163 0.90 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 6 7 1.6e-07 0.00096 18.9 8.2 1 32 168 205 168 205 0.92 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 6.7e-27 93.0 131.1 7 7 5.7e-07 0.0034 17.1 7.4 1 32 210 242 210 242 0.90 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 1 7 0.004 24 4.7 8.2 1 26 1 21 1 26 0.88 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 2 7 0.011 64 3.3 4.0 1 30 28 51 28 53 0.81 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 3 7 1.1e-05 0.066 12.9 3.3 6 31 66 88 59 89 0.92 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 4 7 0.002 12 5.7 8.8 1 25 101 119 88 125 0.86 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 5 7 0.00066 4 7.2 3.7 5 28 138 158 132 161 0.88 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 6 7 0.98 5.8e+03 -3.0 6.7 21 30 193 202 163 204 0.71 EGF-like domain +EGF PF00008.20 32 jgi|Monbr1|2753|gw1.4.410.1 - 242 0.0079 15.8 9.4 7 7 1.3e-06 0.0079 15.8 6.5 4 32 212 241 205 241 0.88 EGF-like domain +IGPD PF00475.11 145 jgi|Monbr1|2754|gw1.2.701.1 - 170 5.7e-63 210.7 0.4 1 1 5.5e-67 6.5e-63 210.6 0.3 1 145 9 153 9 153 1.00 Imidazoleglycerol-phosphate dehydratase +Glyco_transf_8 PF01501.13 242 jgi|Monbr1|2764|gw1.8.280.1 - 191 1.2e-35 122.6 0.0 1 1 1.2e-39 1.4e-35 122.4 0.0 75 241 1 179 1 180 0.95 Glycosyl transferase family 8 +TPR_1 PF00515.21 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.8e-36 121.9 17.7 1 4 3.3e-13 1.7e-10 39.7 0.3 1 30 16 45 16 46 0.94 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.8e-36 121.9 17.7 2 4 9.8e-09 5.1e-06 25.5 0.3 1 30 58 87 58 88 0.95 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.8e-36 121.9 17.7 3 4 1.7e-13 8.9e-11 40.6 0.4 1 30 100 129 100 130 0.94 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.8e-36 121.9 17.7 4 4 2.8e-09 1.4e-06 27.3 0.2 1 30 142 171 142 172 0.95 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.8e-28 94.8 15.0 1 4 1e-10 5.4e-08 31.8 0.3 2 29 17 44 16 46 0.93 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.8e-28 94.8 15.0 2 4 1.4e-06 0.00071 19.0 0.2 1 30 58 87 58 89 0.94 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.8e-28 94.8 15.0 3 4 5.1e-11 2.6e-08 32.8 0.3 2 30 101 129 100 130 0.94 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.8e-28 94.8 15.0 4 4 6e-07 0.00031 20.1 0.1 1 30 142 171 142 172 0.94 Tetratricopeptide repeat +PPR PF01535.13 31 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.6e-10 39.9 4.0 1 4 0.00014 0.075 12.7 0.0 2 27 18 43 17 47 0.91 PPR repeat +PPR PF01535.13 31 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.6e-10 39.9 4.0 2 4 0.0063 3.3 7.6 0.0 2 23 60 81 59 87 0.90 PPR repeat +PPR PF01535.13 31 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.6e-10 39.9 4.0 3 4 0.00011 0.055 13.1 0.0 2 28 102 128 101 131 0.90 PPR repeat +PPR PF01535.13 31 jgi|Monbr1|2766|gw1.6.278.1 - 174 1.6e-10 39.9 4.0 4 4 0.029 15 5.5 0.0 2 23 144 165 143 171 0.89 PPR repeat +DUF357 PF04010.6 75 jgi|Monbr1|2766|gw1.6.278.1 - 174 7e-07 28.5 2.4 1 4 0.0014 0.73 9.2 0.1 33 57 14 38 4 40 0.88 Protein of unknown function (DUF357) +DUF357 PF04010.6 75 jgi|Monbr1|2766|gw1.6.278.1 - 174 7e-07 28.5 2.4 2 4 0.09 46 3.4 0.0 31 56 54 79 44 84 0.88 Protein of unknown function (DUF357) +DUF357 PF04010.6 75 jgi|Monbr1|2766|gw1.6.278.1 - 174 7e-07 28.5 2.4 3 4 0.00099 0.51 9.7 0.1 24 57 89 122 81 124 0.83 Protein of unknown function (DUF357) +DUF357 PF04010.6 75 jgi|Monbr1|2766|gw1.6.278.1 - 174 7e-07 28.5 2.4 4 4 0.11 56 3.2 0.0 31 56 138 163 128 166 0.88 Protein of unknown function (DUF357) +TPR_3 PF07720.5 36 jgi|Monbr1|2766|gw1.6.278.1 - 174 9.8e-06 24.9 14.6 1 4 5.3e-05 0.027 13.9 1.4 10 28 25 42 16 44 0.88 Tetratricopeptide repeat +TPR_3 PF07720.5 36 jgi|Monbr1|2766|gw1.6.278.1 - 174 9.8e-06 24.9 14.6 2 4 2.9 1.5e+03 -1.2 0.0 7 23 64 80 57 80 0.55 Tetratricopeptide repeat +TPR_3 PF07720.5 36 jgi|Monbr1|2766|gw1.6.278.1 - 174 9.8e-06 24.9 14.6 3 4 3.4e-05 0.018 14.5 1.2 10 29 109 127 100 129 0.88 Tetratricopeptide repeat +TPR_3 PF07720.5 36 jgi|Monbr1|2766|gw1.6.278.1 - 174 9.8e-06 24.9 14.6 4 4 1.1 5.5e+02 0.2 0.0 8 16 142 150 137 151 0.85 Tetratricopeptide repeat +Rab5-bind PF09311.4 181 jgi|Monbr1|2766|gw1.6.278.1 - 174 1e-05 25.1 0.0 1 4 0.0015 0.76 9.3 0.0 135 180 11 56 5 57 0.93 Rab5 binding +Rab5-bind PF09311.4 181 jgi|Monbr1|2766|gw1.6.278.1 - 174 1e-05 25.1 0.0 2 4 0.1 53 3.3 0.0 141 180 59 98 58 98 0.92 Rab5 binding +Rab5-bind PF09311.4 181 jgi|Monbr1|2766|gw1.6.278.1 - 174 1e-05 25.1 0.0 3 4 0.00022 0.12 11.9 0.0 126 180 86 140 75 141 0.92 Rab5 binding +Rab5-bind PF09311.4 181 jgi|Monbr1|2766|gw1.6.278.1 - 174 1e-05 25.1 0.0 4 4 0.91 4.7e+02 0.2 0.0 136 168 138 170 135 173 0.85 Rab5 binding +RPN7 PF10602.2 177 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.9e-05 22.7 10.7 1 4 0.00051 0.26 10.3 0.2 34 65 14 45 11 53 0.88 26S proteasome subunit RPN7 +RPN7 PF10602.2 177 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.9e-05 22.7 10.7 2 4 0.061 32 3.5 0.1 34 64 56 86 52 96 0.88 26S proteasome subunit RPN7 +RPN7 PF10602.2 177 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.9e-05 22.7 10.7 3 4 0.00041 0.21 10.6 0.2 34 64 98 128 93 138 0.88 26S proteasome subunit RPN7 +RPN7 PF10602.2 177 jgi|Monbr1|2766|gw1.6.278.1 - 174 3.9e-05 22.7 10.7 4 4 0.054 28 3.7 0.0 34 63 140 169 133 172 0.74 26S proteasome subunit RPN7 +TPR_4 PF07721.7 26 jgi|Monbr1|2766|gw1.6.278.1 - 174 4.8e-05 23.0 1.7 1 4 0.014 7.3 7.0 0.0 3 22 18 37 16 37 0.89 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|2766|gw1.6.278.1 - 174 4.8e-05 23.0 1.7 2 4 0.26 1.4e+02 3.1 0.0 1 21 58 78 58 79 0.86 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|2766|gw1.6.278.1 - 174 4.8e-05 23.0 1.7 3 4 0.014 7.3 7.0 0.0 3 22 102 121 100 121 0.89 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|2766|gw1.6.278.1 - 174 4.8e-05 23.0 1.7 4 4 0.79 4.1e+02 1.6 0.0 2 21 143 162 142 163 0.81 Tetratricopeptide repeat +Pep3_Vps18 PF05131.7 147 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.0015 17.6 0.8 1 4 0.036 19 4.3 0.0 108 128 21 41 19 51 0.83 Pep3/Vps18/deep orange family +Pep3_Vps18 PF05131.7 147 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.0015 17.6 0.8 2 4 0.12 62 2.6 0.0 111 129 66 84 61 95 0.82 Pep3/Vps18/deep orange family +Pep3_Vps18 PF05131.7 147 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.0015 17.6 0.8 3 4 0.043 22 4.1 0.0 108 128 105 125 103 134 0.85 Pep3/Vps18/deep orange family +Pep3_Vps18 PF05131.7 147 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.0015 17.6 0.8 4 4 0.21 1.1e+02 1.8 0.0 111 128 150 167 146 173 0.84 Pep3/Vps18/deep orange family +UBA PF00627.24 37 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.005 16.3 0.6 1 2 0.011 5.5 6.6 0.0 17 31 72 86 69 87 0.84 UBA/TS-N domain +UBA PF00627.24 37 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.005 16.3 0.6 2 2 0.011 5.5 6.6 0.0 17 31 156 170 153 171 0.84 UBA/TS-N domain +Foie-gras_1 PF11817.1 260 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.0062 15.6 1.0 1 2 0.0052 2.7 7.0 0.1 196 217 21 42 15 49 0.87 Foie gras liver health family 1 +Foie-gras_1 PF11817.1 260 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.0062 15.6 1.0 2 2 0.0039 2 7.4 0.1 195 217 104 126 84 133 0.86 Foie gras liver health family 1 +SPO22 PF08631.3 280 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.012 14.4 3.6 1 2 0.0054 2.8 6.6 0.1 253 275 21 43 15 47 0.90 Meiosis protein SPO22/ZIP4 like +SPO22 PF08631.3 280 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.012 14.4 3.6 2 2 0.0012 0.64 8.7 0.3 3 65 68 129 66 171 0.67 Meiosis protein SPO22/ZIP4 like +DUF2225 PF09986.2 214 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.015 14.4 2.8 1 2 0.0035 1.8 7.6 0.2 125 193 16 86 11 96 0.69 Uncharacterized protein conserved in bacteria (DUF2225) +DUF2225 PF09986.2 214 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.015 14.4 2.8 2 2 0.0035 1.8 7.6 0.1 124 192 99 169 80 173 0.74 Uncharacterized protein conserved in bacteria (DUF2225) +SHNi-TPR PF10516.2 38 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.019 13.9 5.0 1 4 0.39 2e+02 1.0 0.0 24 36 32 44 30 46 0.88 SHNi-TPR +SHNi-TPR PF10516.2 38 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.019 13.9 5.0 2 4 0.019 9.8 5.2 0.1 3 32 60 89 58 94 0.90 SHNi-TPR +SHNi-TPR PF10516.2 38 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.019 13.9 5.0 3 4 0.41 2.1e+02 0.9 0.0 24 35 116 127 112 130 0.75 SHNi-TPR +SHNi-TPR PF10516.2 38 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.019 13.9 5.0 4 4 0.01 5.4 6.0 0.0 3 32 144 173 142 174 0.92 SHNi-TPR +DUF2753 PF10952.1 140 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.024 14.3 0.8 1 2 0.002 1 9.0 0.1 7 80 15 88 10 101 0.84 Protein of unknown function (DUF2753) +DUF2753 PF10952.1 140 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.024 14.3 0.8 2 2 0.044 23 4.6 0.0 3 76 95 168 93 174 0.84 Protein of unknown function (DUF2753) +DUF627 PF04781.5 112 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.027 13.7 6.1 1 4 0.019 9.9 5.5 0.1 74 108 12 46 6 51 0.88 Protein of unknown function (DUF627) +DUF627 PF04781.5 112 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.027 13.7 6.1 2 4 0.17 87 2.4 0.0 74 107 54 87 47 93 0.89 Protein of unknown function (DUF627) +DUF627 PF04781.5 112 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.027 13.7 6.1 3 4 0.04 21 4.5 0.1 74 107 96 129 89 133 0.84 Protein of unknown function (DUF627) +DUF627 PF04781.5 112 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.027 13.7 6.1 4 4 0.18 92 2.4 0.0 74 107 138 171 131 173 0.89 Protein of unknown function (DUF627) +BTAD PF03704.10 146 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.035 14.0 5.6 1 3 0.035 18 5.2 0.2 98 131 18 51 5 65 0.78 Bacterial transcriptional activator domain +BTAD PF03704.10 146 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.035 14.0 5.6 2 3 0.00054 0.28 11.1 0.6 79 131 83 135 57 148 0.80 Bacterial transcriptional activator domain +BTAD PF03704.10 146 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.035 14.0 5.6 3 3 6.8 3.5e+03 -2.2 0.0 13 34 149 170 139 171 0.74 Bacterial transcriptional activator domain +Sipho_tail PF05709.4 248 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.045 12.5 0.0 1 2 0.0041 2.1 7.0 0.0 8 63 11 67 5 73 0.86 Phage tail protein +Sipho_tail PF05709.4 248 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.045 12.5 0.0 2 2 0.046 24 3.6 0.0 9 61 96 149 90 156 0.89 Phage tail protein +IML2 PF10300.2 466 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.046 12.0 0.3 1 2 0.00033 0.17 10.1 0.2 238 329 34 128 5 131 0.73 Putative mitochondrial outer membrane protein +IML2 PF10300.2 466 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.046 12.0 0.3 2 2 0.00045 0.23 9.6 0.1 224 290 61 128 36 172 0.56 Putative mitochondrial outer membrane protein +Chitin_bind_1 PF00187.12 40 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.047 13.3 2.6 1 2 0.011 5.8 6.6 0.1 16 34 66 83 60 88 0.83 Chitin recognition protein +Chitin_bind_1 PF00187.12 40 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.047 13.3 2.6 2 2 0.012 6.1 6.6 0.2 16 34 150 167 145 172 0.82 Chitin recognition protein +DUF2959 PF11172.1 201 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.049 13.0 0.2 1 2 0.011 5.5 6.3 0.0 40 77 28 65 21 85 0.88 Protein of unknown function (DUF2959) +DUF2959 PF11172.1 201 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.049 13.0 0.2 2 2 0.04 21 4.5 0.0 40 75 112 147 106 153 0.91 Protein of unknown function (DUF2959) +MIT PF04212.11 69 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.14 11.7 12.7 1 4 0.0029 1.5 8.4 0.2 18 33 29 44 14 51 0.82 MIT (microtubule interacting and transport) domain +MIT PF04212.11 69 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.14 11.7 12.7 2 4 0.35 1.8e+02 1.7 0.2 18 39 71 92 57 112 0.81 MIT (microtubule interacting and transport) domain +MIT PF04212.11 69 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.14 11.7 12.7 3 4 0.021 11 5.7 2.4 17 33 112 128 76 134 0.86 MIT (microtubule interacting and transport) domain +MIT PF04212.11 69 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.14 11.7 12.7 4 4 1.5 8e+02 -0.3 0.0 19 33 156 170 154 173 0.59 MIT (microtubule interacting and transport) domain +EGF_2 PF07974.6 32 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.66 9.8 6.4 1 2 0.016 8.3 6.3 0.3 6 19 66 82 60 83 0.81 EGF-like domain +EGF_2 PF07974.6 32 jgi|Monbr1|2766|gw1.6.278.1 - 174 0.66 9.8 6.4 2 2 0.015 7.8 6.4 0.6 5 19 149 166 145 167 0.81 EGF-like domain +NHL PF01436.14 28 jgi|Monbr1|2797|gw1.4.419.1 - 119 5.2e-05 22.6 0.2 1 1 3.3e-08 0.00019 20.8 0.2 1 27 79 106 79 107 0.95 NHL repeat +PQQ PF01011.14 38 jgi|Monbr1|2797|gw1.4.419.1 - 119 0.00046 19.2 0.5 1 3 1.6 9.8e+03 -3.9 0.0 10 14 10 14 8 14 0.79 PQQ enzyme repeat +PQQ PF01011.14 38 jgi|Monbr1|2797|gw1.4.419.1 - 119 0.00046 19.2 0.5 2 3 0.025 1.5e+02 1.9 0.0 17 25 60 68 51 69 0.77 PQQ enzyme repeat +PQQ PF01011.14 38 jgi|Monbr1|2797|gw1.4.419.1 - 119 0.00046 19.2 0.5 3 3 1.8e-06 0.011 14.9 0.0 3 27 94 119 93 119 0.91 PQQ enzyme repeat +HCaRG PF07258.7 178 jgi|Monbr1|2798|gw1.8.281.1 - 130 1.3e-17 63.6 0.2 1 1 1.1e-21 1.3e-17 63.6 0.1 54 173 6 125 1 130 0.89 HCaRG protein +Abi PF02517.9 99 jgi|Monbr1|2805|gw1.5.334.1 - 100 3.2e-15 55.9 4.7 1 1 2.9e-19 3.5e-15 55.8 3.3 3 96 2 99 1 100 0.93 CAAX amino terminal protease family +DnaJ PF00226.24 64 jgi|Monbr1|2825|gw1.5.338.1 - 193 9.4e-20 69.8 2.4 1 2 8.7e-23 3.5e-19 67.9 0.3 2 64 16 79 15 79 0.97 DnaJ domain +DnaJ PF00226.24 64 jgi|Monbr1|2825|gw1.5.338.1 - 193 9.4e-20 69.8 2.4 2 2 0.057 2.3e+02 1.3 0.0 14 23 127 136 121 138 0.82 DnaJ domain +AIP3 PF03915.6 422 jgi|Monbr1|2825|gw1.5.338.1 - 193 0.024 13.2 0.1 1 1 1e-05 0.041 12.4 0.0 308 368 15 75 2 77 0.89 Actin interacting protein 3 +YodA PF09223.4 182 jgi|Monbr1|2825|gw1.5.338.1 - 193 0.045 13.1 0.2 1 1 2.2e-05 0.086 12.1 0.2 8 64 81 135 72 157 0.79 YodA +NIF PF03031.11 148 jgi|Monbr1|2855|gw1.6.296.1 - 167 5.1e-46 155.8 0.0 1 1 4.8e-50 5.7e-46 155.6 0.0 2 141 14 166 13 167 0.89 NLI interacting factor-like phosphatase +TBC PF00566.11 214 jgi|Monbr1|2868|gw1.4.423.1 - 211 4.5e-41 140.3 0.1 1 1 4.8e-45 5.7e-41 140.0 0.1 54 213 1 162 1 163 0.93 TBC domain +Pkinase PF00069.18 260 jgi|Monbr1|2871|gw1.8.288.1 - 171 6.4e-41 139.9 0.0 1 1 3.6e-44 7.1e-41 139.7 0.0 27 192 1 170 1 171 0.96 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|2871|gw1.8.288.1 - 171 2.6e-25 88.7 0.0 1 1 1.4e-28 2.8e-25 88.5 0.0 31 198 1 170 1 171 0.85 Protein tyrosine kinase +Kdo PF06293.7 206 jgi|Monbr1|2871|gw1.8.288.1 - 171 1.3e-09 37.0 0.1 1 1 8.3e-13 1.6e-09 36.7 0.0 56 177 17 134 3 165 0.79 Lipopolysaccharide kinase (Kdo/WaaP) family +APH PF01636.16 238 jgi|Monbr1|2871|gw1.8.288.1 - 171 0.00022 20.7 0.5 1 2 0.00075 1.5 8.1 0.2 33 108 15 98 4 99 0.77 Phosphotransferase enzyme family +APH PF01636.16 238 jgi|Monbr1|2871|gw1.8.288.1 - 171 0.00022 20.7 0.5 2 2 3.1e-05 0.063 12.7 0.0 164 196 97 128 71 148 0.77 Phosphotransferase enzyme family +Seadorna_VP7 PF07387.4 308 jgi|Monbr1|2871|gw1.8.288.1 - 171 0.016 13.7 0.0 1 1 9.2e-06 0.018 13.5 0.0 146 188 84 124 49 141 0.81 Seadornavirus VP7 +Pox_ser-thr_kin PF05445.4 434 jgi|Monbr1|2871|gw1.8.288.1 - 171 0.032 12.7 0.0 1 1 2e-05 0.039 12.4 0.0 274 312 78 112 55 128 0.80 Poxvirus serine/threonine protein kinase +TPR_1 PF00515.21 34 jgi|Monbr1|2888|gw1.7.261.1 - 125 1.2e-08 33.9 2.4 1 3 9.5e-05 0.57 9.5 0.0 8 34 45 71 41 71 0.91 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|2888|gw1.7.261.1 - 125 1.2e-08 33.9 2.4 2 3 1.5e-06 0.009 15.2 0.0 3 31 74 102 73 105 0.93 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|2888|gw1.7.261.1 - 125 1.2e-08 33.9 2.4 3 3 0.00031 1.8 7.9 0.1 2 20 107 125 106 125 0.95 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2888|gw1.7.261.1 - 125 4.9e-06 25.7 7.4 1 3 6.8e-06 0.041 13.5 0.1 6 29 43 66 39 71 0.89 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2888|gw1.7.261.1 - 125 4.9e-06 25.7 7.4 2 3 0.0014 8.1 6.3 0.2 4 31 75 102 73 105 0.88 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|2888|gw1.7.261.1 - 125 4.9e-06 25.7 7.4 3 3 0.00014 0.84 9.4 0.1 2 20 107 125 106 125 0.95 Tetratricopeptide repeat +Peptidase_M14 PF00246.17 277 jgi|Monbr1|2908|gw1.3.538.1 - 197 2.2e-18 66.5 0.0 1 1 2.6e-22 3.1e-18 66.0 0.0 5 130 57 180 53 196 0.90 Zinc carboxypeptidase +Arf PF00025.14 175 jgi|Monbr1|2913|gw1.2.753.1 - 167 9.6e-37 125.5 0.0 1 1 6.5e-40 1.1e-36 125.4 0.0 7 160 10 166 4 167 0.88 ADP-ribosylation factor family +G-alpha PF00503.13 351 jgi|Monbr1|2913|gw1.2.753.1 - 167 6.2e-10 38.3 0.0 1 2 4.6e-06 0.0079 14.9 0.0 26 61 15 50 10 58 0.88 G-protein alpha subunit +G-alpha PF00503.13 351 jgi|Monbr1|2913|gw1.2.753.1 - 167 6.2e-10 38.3 0.0 2 2 6.9e-08 0.00012 21.0 0.0 192 272 65 135 57 159 0.86 G-protein alpha subunit +Ras PF00071.15 162 jgi|Monbr1|2913|gw1.2.753.1 - 167 1.3e-09 37.3 0.0 1 1 1.8e-12 3.1e-09 36.1 0.0 2 127 20 143 19 166 0.78 Ras family +SRPRB PF09439.3 181 jgi|Monbr1|2913|gw1.2.753.1 - 167 6.6e-09 34.9 0.0 1 1 5.4e-12 9.2e-09 34.4 0.0 5 136 19 144 15 165 0.77 Signal recognition particle receptor beta subunit +Miro PF08477.6 119 jgi|Monbr1|2913|gw1.2.753.1 - 167 8.7e-08 32.3 0.0 1 1 8.2e-11 1.4e-07 31.7 0.0 2 119 20 131 19 131 0.81 Miro-like protein +Gtr1_RagA PF04670.5 231 jgi|Monbr1|2913|gw1.2.753.1 - 167 0.00016 20.6 0.0 1 1 1.9e-07 0.00032 19.6 0.0 2 102 20 113 19 142 0.73 Gtr1/RagA G protein conserved region +GTP_EFTU PF00009.20 189 jgi|Monbr1|2913|gw1.2.753.1 - 167 0.011 14.8 0.0 1 1 0.00013 0.23 10.5 0.0 71 171 64 165 16 167 0.70 Elongation factor Tu GTP binding domain +Ras PF00071.15 162 jgi|Monbr1|2929|gw1.2.762.1 - 178 5.6e-28 97.0 0.0 1 1 4.2e-31 6.2e-28 96.9 0.0 1 160 10 171 10 173 0.95 Ras family +Miro PF08477.6 119 jgi|Monbr1|2929|gw1.2.762.1 - 178 2.1e-20 73.1 0.0 1 1 1.8e-23 2.6e-20 72.7 0.0 1 119 10 126 10 126 0.95 Miro-like protein +Arf PF00025.14 175 jgi|Monbr1|2929|gw1.2.762.1 - 178 1.3e-10 40.4 0.0 1 1 1e-13 1.5e-10 40.2 0.0 12 135 6 135 1 165 0.86 ADP-ribosylation factor family +GTP_EFTU PF00009.20 189 jgi|Monbr1|2929|gw1.2.762.1 - 178 0.0033 16.5 0.0 1 1 5e-06 0.0075 15.3 0.0 43 156 30 149 6 166 0.73 Elongation factor Tu GTP binding domain +Gtr1_RagA PF04670.5 231 jgi|Monbr1|2929|gw1.2.762.1 - 178 0.0059 15.4 0.0 1 1 5.7e-06 0.0085 14.9 0.0 1 125 10 129 10 155 0.71 Gtr1/RagA G protein conserved region +NACHT PF05729.5 166 jgi|Monbr1|2929|gw1.2.762.1 - 178 0.0068 15.7 0.1 1 2 0.0035 5.2 6.3 0.0 3 18 11 26 10 31 0.88 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|2929|gw1.2.762.1 - 178 0.0068 15.7 0.1 2 2 0.0017 2.5 7.4 0.0 17 76 100 167 99 176 0.86 NACHT domain +AIG1 PF04548.9 212 jgi|Monbr1|2929|gw1.2.762.1 - 178 0.049 12.4 0.0 1 1 5.2e-05 0.078 11.7 0.0 2 44 10 52 9 110 0.82 AIG1 family +NPHI_C PF08469.3 148 jgi|Monbr1|2929|gw1.2.762.1 - 178 0.083 12.4 0.0 1 1 8.9e-05 0.13 11.8 0.0 40 90 83 134 78 143 0.86 Nucleoside triphosphatase I C-terminal +Y_phosphatase PF00102.20 235 jgi|Monbr1|2986|gw1.7.271.1 - 62 2.4e-20 72.6 0.0 1 1 6.3e-24 2.5e-20 72.5 0.0 130 188 3 62 1 62 0.93 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|2986|gw1.7.271.1 - 62 0.00022 20.4 0.0 1 1 5.6e-08 0.00022 20.4 0.0 63 91 34 62 3 62 0.72 Dual specificity phosphatase, catalytic domain +Y_phosphatase2 PF03162.6 165 jgi|Monbr1|2986|gw1.7.271.1 - 62 0.016 14.2 0.0 1 1 4.2e-06 0.017 14.2 0.0 59 109 7 62 1 62 0.75 Tyrosine phosphatase family +Peptidase_M48 PF01435.11 225 jgi|Monbr1|3000|gw1.7.272.1 - 116 2.4e-19 69.4 0.4 1 1 1.1e-22 6.5e-19 68.0 0.3 51 181 2 115 1 116 0.86 Peptidase family M48 +SprT-like PF10263.2 159 jgi|Monbr1|3000|gw1.7.272.1 - 116 0.036 13.4 0.1 1 1 6.7e-06 0.04 13.2 0.1 55 75 32 52 24 96 0.85 SprT-like family +Fer2_2 PF01799.13 75 jgi|Monbr1|3012|gw1.8.307.1 - 156 7.7e-27 92.6 0.3 1 1 4.1e-30 1.2e-26 92.0 0.2 1 74 78 152 78 153 0.96 [2Fe-2S] binding domain +Fer2 PF00111.20 77 jgi|Monbr1|3012|gw1.8.307.1 - 156 1.5e-08 34.0 0.8 1 2 4.9e-12 1.5e-08 34.0 0.6 2 50 4 53 3 69 0.83 2Fe-2S iron-sulfur cluster binding domain +Fer2 PF00111.20 77 jgi|Monbr1|3012|gw1.8.307.1 - 156 1.5e-08 34.0 0.8 2 2 0.098 2.9e+02 0.9 0.2 38 53 102 121 86 142 0.62 2Fe-2S iron-sulfur cluster binding domain +SUI1 PF01253.15 83 jgi|Monbr1|3012|gw1.8.307.1 - 156 0.048 13.1 0.1 1 2 0.029 87 2.7 0.0 29 52 23 49 3 58 0.59 Translation initiation factor SUI1 +SUI1 PF01253.15 83 jgi|Monbr1|3012|gw1.8.307.1 - 156 0.048 13.1 0.1 2 2 0.00049 1.4 8.4 0.0 19 48 75 104 71 129 0.84 Translation initiation factor SUI1 +DHODB_Fe-S_bind PF10418.2 40 jgi|Monbr1|3012|gw1.8.307.1 - 156 0.72 9.0 10.8 1 2 5e-05 0.15 11.2 3.2 6 21 38 53 36 66 0.82 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B +DHODB_Fe-S_bind PF10418.2 40 jgi|Monbr1|3012|gw1.8.307.1 - 156 0.72 9.0 10.8 2 2 0.092 2.7e+02 0.8 0.3 11 17 104 110 102 114 0.82 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B +DUF2452 PF10504.2 160 jgi|Monbr1|3023|gw1.7.273.1 - 136 1.9e-50 169.9 0.2 1 1 5.2e-54 2.1e-50 169.8 0.2 19 147 3 135 1 136 0.96 Protein of unknown function (DUF2452) +Zot PF05707.5 193 jgi|Monbr1|3023|gw1.7.273.1 - 136 0.11 11.6 0.8 1 1 7.2e-05 0.29 10.2 0.2 120 147 39 66 33 95 0.74 Zonular occludens toxin (Zot) +Phasin_2 PF09361.3 102 jgi|Monbr1|3023|gw1.7.273.1 - 136 0.59 9.8 2.5 1 3 0.35 1.4e+03 -1.0 0.0 46 65 2 21 1 30 0.70 Phasin protein +Phasin_2 PF09361.3 102 jgi|Monbr1|3023|gw1.7.273.1 - 136 0.59 9.8 2.5 2 3 0.0006 2.4 7.9 2.0 42 86 24 66 14 68 0.74 Phasin protein +Phasin_2 PF09361.3 102 jgi|Monbr1|3023|gw1.7.273.1 - 136 0.59 9.8 2.5 3 3 2.1 8.2e+03 -3.4 0.0 50 67 94 112 93 114 0.69 Phasin protein +DSPc PF00782.13 133 jgi|Monbr1|3024|gw1.7.274.1 - 131 2.9e-28 97.7 0.0 1 1 5.4e-32 3.2e-28 97.6 0.0 1 131 1 130 1 131 0.96 Dual specificity phosphatase, catalytic domain +Y_phosphatase PF00102.20 235 jgi|Monbr1|3024|gw1.7.274.1 - 131 2.8e-05 23.3 0.0 1 1 5e-09 3e-05 23.2 0.0 166 211 67 114 16 118 0.72 Protein-tyrosine phosphatase +CRAL_TRIO PF00650.13 139 jgi|Monbr1|3060|gw1.4.445.1 - 112 2.6e-22 78.5 0.0 1 1 2.5e-26 2.9e-22 78.4 0.0 1 112 7 112 7 112 0.97 CRAL/TRIO domain +Calcipressin PF04847.5 185 jgi|Monbr1|3061|gw1.8.315.1 - 53 3.4e-16 59.0 5.2 1 1 2.9e-20 3.4e-16 59.0 3.6 82 132 1 48 1 53 0.94 Calcipressin +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|3066|gw1.2.788.1 - 139 1.2e-51 175.0 0.0 1 1 2.2e-55 1.3e-51 174.9 0.0 111 252 1 139 1 139 0.99 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|3066|gw1.2.788.1 - 139 8e-26 90.4 0.0 1 1 1.5e-29 8.9e-26 90.2 0.0 106 250 1 138 1 139 0.92 Protein kinase domain +Cytochrom_B558a PF05038.6 186 jgi|Monbr1|3080|gw1.8.321.1 - 110 6.3e-29 100.5 0.1 1 1 1.2e-32 7e-29 100.4 0.1 45 157 1 110 1 110 0.92 Cytochrome Cytochrome b558 alpha-subunit +Cg6151-P PF10233.2 113 jgi|Monbr1|3080|gw1.8.321.1 - 110 0.24 11.0 1.3 1 1 8.3e-05 0.49 10.0 0.9 36 112 2 83 1 84 0.56 Uncharacterized conserved protein CG6151-P +Y_phosphatase PF00102.20 235 jgi|Monbr1|3088|gw1.8.322.1 - 171 8.7e-47 159.1 0.0 1 1 2.4e-50 9.6e-47 159.0 0.0 66 235 2 169 1 169 0.98 Protein-tyrosine phosphatase +DSPc PF00782.13 133 jgi|Monbr1|3088|gw1.8.322.1 - 171 1e-05 24.8 0.0 1 1 3.5e-09 1.4e-05 24.3 0.0 63 91 90 122 37 131 0.79 Dual specificity phosphatase, catalytic domain +Y_phosphatase2 PF03162.6 165 jgi|Monbr1|3088|gw1.8.322.1 - 171 0.032 13.2 0.0 1 1 9e-06 0.036 13.1 0.0 86 120 99 133 40 141 0.88 Tyrosine phosphatase family +TMPIT PF07851.6 330 jgi|Monbr1|3096|gw1.7.278.1 - 97 9.5e-34 116.6 7.9 1 1 8.7e-38 1e-33 116.5 5.5 154 250 1 97 1 97 0.97 TMPIT-like protein +NDT80_PhoG PF05224.5 186 jgi|Monbr1|3104|gw1.2.799.1 - 172 1e-10 41.6 0.0 1 2 1.7e-14 2e-10 40.6 0.0 132 185 2 56 1 57 0.94 NDT80 / PhoG like DNA-binding family +NDT80_PhoG PF05224.5 186 jgi|Monbr1|3104|gw1.2.799.1 - 172 1e-10 41.6 0.0 2 2 0.31 3.7e+03 -2.6 0.0 100 124 103 127 85 134 0.57 NDT80 / PhoG like DNA-binding family +SNARE_assoc PF09335.4 123 jgi|Monbr1|3127|gw1.7.284.1 - 146 6e-10 39.0 1.6 1 2 4.5e-13 6e-10 39.0 1.1 23 122 2 98 1 99 0.86 SNARE associated Golgi protein +SNARE_assoc PF09335.4 123 jgi|Monbr1|3127|gw1.7.284.1 - 146 6e-10 39.0 1.6 2 2 3.7 4.9e+03 -2.7 0.1 7 20 119 132 115 137 0.41 SNARE associated Golgi protein +PTS_EIIC PF02378.11 321 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.011 14.2 1.1 1 2 0.00014 0.19 10.2 0.0 123 151 3 31 2 71 0.86 Phosphotransferase system, EIIC +PTS_EIIC PF02378.11 321 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.011 14.2 1.1 2 2 0.025 33 2.8 0.3 90 142 84 136 66 145 0.72 Phosphotransferase system, EIIC +SHR3_chaperone PF08229.4 196 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.013 14.1 0.2 1 1 1.1e-05 0.014 14.0 0.1 88 143 77 130 25 138 0.80 ER membrane protein SH3 +DUF1469 PF07332.4 121 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.046 13.1 0.4 1 2 1.7 2.2e+03 -2.0 0.0 85 97 8 20 3 44 0.52 Protein of unknown function (DUF1469) +DUF1469 PF07332.4 121 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.046 13.1 0.4 2 2 7.5e-05 0.099 12.0 0.2 36 101 76 143 67 146 0.87 Protein of unknown function (DUF1469) +DUF1294 PF06961.6 55 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.074 12.7 0.2 1 1 0.0001 0.13 11.8 0.2 30 48 1 19 1 22 0.92 Protein of unknown function (DUF1294) +zf-LITAF-like PF10601.2 73 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.078 12.5 0.1 1 2 0.00049 0.64 9.6 0.0 8 35 15 42 12 68 0.71 LITAF-like zinc ribbon domain +zf-LITAF-like PF10601.2 73 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.078 12.5 0.1 2 2 0.32 4.2e+02 0.5 0.0 31 54 118 139 88 142 0.64 LITAF-like zinc ribbon domain +DUF26 PF01657.10 53 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.12 11.7 0.1 1 1 0.00015 0.2 11.0 0.1 15 49 16 57 12 61 0.76 Domain of unknown function DUF26 +UPF0016 PF01169.12 78 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.12 12.2 2.3 1 2 0.5 6.6e+02 0.2 0.0 37 46 8 17 1 35 0.63 Uncharacterized protein family UPF0016 +UPF0016 PF01169.12 78 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.12 12.2 2.3 2 2 0.00044 0.59 10.0 0.7 25 59 70 102 65 137 0.82 Uncharacterized protein family UPF0016 +DuoxA PF10204.2 281 jgi|Monbr1|3127|gw1.7.284.1 - 146 0.22 10.2 0.9 1 1 0.00021 0.27 9.9 0.6 178 270 56 144 48 146 0.76 Dual oxidase maturation factor +UCH PF00443.22 271 jgi|Monbr1|3133|gw1.5.364.1 - 157 1.3e-29 102.8 0.1 1 1 3.7e-33 1.5e-29 102.6 0.0 148 271 3 152 1 152 0.91 Ubiquitin carboxyl-terminal hydrolase +AA_kinase PF00696.21 243 jgi|Monbr1|3133|gw1.5.364.1 - 157 0.079 12.1 0.0 1 1 2.7e-05 0.11 11.7 0.0 35 103 73 146 52 152 0.72 Amino acid kinase family +Paramyx_RNA_pol PF00946.12 1168 jgi|Monbr1|3133|gw1.5.364.1 - 157 0.083 9.8 0.0 1 1 2.7e-05 0.11 9.4 0.0 428 468 27 67 18 70 0.92 Paramyxovirus RNA dependent RNA polymerase +dCMP_cyt_deam_1 PF00383.15 102 jgi|Monbr1|3136|gw1.7.285.1 - 143 7.6e-27 92.6 0.6 1 1 1.5e-30 8.9e-27 92.4 0.4 4 101 9 121 6 122 0.96 Cytidine and deoxycytidylate deaminase zinc-binding region +APOBEC_N PF08210.4 117 jgi|Monbr1|3136|gw1.7.285.1 - 143 0.051 13.6 0.2 1 1 1.4e-05 0.085 12.9 0.2 50 98 70 112 51 116 0.71 APOBEC-like N-terminal domain +RRM_1 PF00076.15 70 jgi|Monbr1|3176|gw1.3.593.1 - 95 1.2e-19 69.3 0.0 1 1 1.2e-23 1.5e-19 69.1 0.0 1 70 13 82 13 82 0.99 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +TBC PF00566.11 214 jgi|Monbr1|3177|gw1.7.290.1 - 140 3.8e-33 114.4 1.0 1 1 3.5e-37 4.1e-33 114.3 0.7 50 188 2 139 1 140 0.92 TBC domain +zf-AN1 PF01428.9 43 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.2e-21 75.9 30.8 1 3 9e-12 1.5e-08 34.0 5.8 1 36 10 45 10 55 0.91 AN1-like Zinc finger +zf-AN1 PF01428.9 43 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.2e-21 75.9 30.8 2 3 0.17 2.9e+02 1.1 0.2 14 21 55 62 49 64 0.83 AN1-like Zinc finger +zf-AN1 PF01428.9 43 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.2e-21 75.9 30.8 3 3 3.9e-17 6.7e-14 51.1 5.7 1 38 98 135 98 141 0.94 AN1-like Zinc finger +zf-Sec23_Sec24 PF04810.8 40 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.11 11.7 0.1 1 3 0.06 1e+02 2.3 0.6 4 10 24 30 22 36 0.83 Sec23/Sec24 zinc finger +zf-Sec23_Sec24 PF04810.8 40 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.11 11.7 0.1 2 3 6.7e-05 0.11 11.7 0.0 18 33 49 63 46 68 0.81 Sec23/Sec24 zinc finger +zf-Sec23_Sec24 PF04810.8 40 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.11 11.7 0.1 3 3 2 3.4e+03 -2.6 0.5 5 31 113 117 110 123 0.60 Sec23/Sec24 zinc finger +Rad50_zn_hook PF04423.7 54 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.12 11.6 3.2 1 2 0.00047 0.8 8.9 0.0 18 30 51 64 47 65 0.80 Rad50 zinc hook motif +Rad50_zn_hook PF04423.7 54 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.12 11.6 3.2 2 2 0.045 77 2.6 0.6 22 35 112 125 109 128 0.88 Rad50 zinc hook motif +Ribosomal_S27e PF01667.10 55 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.17 11.1 10.4 1 3 0.0052 8.8 5.6 0.9 28 39 24 35 9 37 0.85 Ribosomal protein S27 +Ribosomal_S27e PF01667.10 55 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.17 11.1 10.4 2 3 0.068 1.2e+02 2.0 0.0 9 37 56 65 46 77 0.67 Ribosomal protein S27 +Ribosomal_S27e PF01667.10 55 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.17 11.1 10.4 3 3 0.0012 2.1 7.6 0.6 3 16 106 119 104 127 0.85 Ribosomal protein S27 +Ins_element1 PF03811.6 88 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.35 10.4 0.2 1 3 0.068 1.2e+02 2.3 1.2 29 47 22 39 14 52 0.73 Insertion element protein +Ins_element1 PF03811.6 88 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.35 10.4 0.2 2 3 0.0002 0.35 10.4 0.1 6 36 55 85 51 90 0.91 Insertion element protein +Ins_element1 PF03811.6 88 jgi|Monbr1|3192|gw1.2.819.1 - 147 0.35 10.4 0.2 3 3 0.13 2.3e+02 1.4 0.6 6 40 111 121 98 139 0.70 Insertion element protein +zf-HIT PF04438.9 30 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.2 8.5 22.3 1 3 0.012 21 4.5 3.1 8 24 15 33 8 33 0.76 HIT zinc finger +zf-HIT PF04438.9 30 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.2 8.5 22.3 2 3 0.0031 5.3 6.4 0.1 13 21 54 62 48 64 0.83 HIT zinc finger +zf-HIT PF04438.9 30 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.2 8.5 22.3 3 3 0.0079 13 5.1 4.2 2 24 95 121 94 122 0.90 HIT zinc finger +IBR PF01485.14 64 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.6 8.3 29.9 1 2 0.1 1.8e+02 1.8 6.2 39 56 16 38 3 46 0.68 IBR domain +IBR PF01485.14 64 jgi|Monbr1|3192|gw1.2.819.1 - 147 1.6 8.3 29.9 2 2 0.00074 1.3 8.6 10.3 20 58 56 128 41 134 0.72 IBR domain +TBC PF00566.11 214 jgi|Monbr1|3202|gw1.5.371.1 - 168 4.4e-34 117.5 0.6 1 1 4.1e-38 4.9e-34 117.3 0.4 26 188 2 165 1 167 0.95 TBC domain +p25-alpha PF05517.5 154 jgi|Monbr1|3203|gw1.3.600.1 - 128 1e-36 126.2 1.4 1 1 9.6e-41 1.1e-36 126.0 0.9 18 137 1 119 1 126 0.96 p25-alpha +Peptidase_S24 PF00717.16 70 jgi|Monbr1|3212|gw1.5.375.1 - 110 2e-12 46.2 0.1 1 2 1.1e-15 4.4e-12 45.1 0.0 4 55 1 58 1 67 0.93 Peptidase S24-like +Peptidase_S24 PF00717.16 70 jgi|Monbr1|3212|gw1.5.375.1 - 110 2e-12 46.2 0.1 2 2 0.52 2e+03 -1.9 0.0 44 60 66 82 59 94 0.67 Peptidase S24-like +Peptidase_S26 PF10502.2 138 jgi|Monbr1|3212|gw1.5.375.1 - 110 1.4e-08 34.0 0.1 1 2 7.4e-05 0.29 10.3 0.0 22 67 27 60 7 63 0.70 Peptidase S26 +Peptidase_S26 PF10502.2 138 jgi|Monbr1|3212|gw1.5.375.1 - 110 1.4e-08 34.0 0.1 2 2 5.8e-08 0.00023 20.3 0.0 92 132 63 103 60 109 0.86 Peptidase S26 +DUF2635 PF10948.1 47 jgi|Monbr1|3212|gw1.5.375.1 - 110 0.1 11.6 0.6 1 4 0.034 1.4e+02 1.6 0.1 38 45 12 19 10 21 0.87 Protein of unknown function (DUF2635) +DUF2635 PF10948.1 47 jgi|Monbr1|3212|gw1.5.375.1 - 110 0.1 11.6 0.6 2 4 0.00091 3.6 6.6 0.0 33 46 25 38 24 39 0.86 Protein of unknown function (DUF2635) +DUF2635 PF10948.1 47 jgi|Monbr1|3212|gw1.5.375.1 - 110 0.1 11.6 0.6 3 4 1.6 6.3e+03 -3.8 0.0 28 35 42 49 40 50 0.79 Protein of unknown function (DUF2635) +DUF2635 PF10948.1 47 jgi|Monbr1|3212|gw1.5.375.1 - 110 0.1 11.6 0.6 4 4 0.26 1e+03 -1.2 0.0 23 32 69 78 69 79 0.85 Protein of unknown function (DUF2635) +RhoGAP PF00620.20 153 jgi|Monbr1|3215|gw1.5.376.1 - 101 2.9e-34 117.5 0.0 1 1 2.6e-38 3.1e-34 117.4 0.0 53 149 2 97 1 101 0.96 RhoGAP domain +Glycos_transf_1 PF00534.13 172 jgi|Monbr1|3219|gw1.2.822.1 - 118 1.4e-10 40.5 0.1 1 1 3.9e-14 2.3e-10 39.8 0.0 93 170 2 93 1 95 0.84 Glycosyl transferases group 1 +Glycogen_syn PF05693.6 633 jgi|Monbr1|3219|gw1.2.822.1 - 118 0.025 12.5 0.0 1 1 4.9e-06 0.029 12.3 0.0 474 549 6 86 3 101 0.78 Glycogen synthase +Ribosomal_S5_C PF03719.8 74 jgi|Monbr1|3220|gw1.3.602.1 - 144 9.9e-19 66.0 0.4 1 2 0.62 3.7e+03 -3.1 0.1 54 62 47 55 43 58 0.67 Ribosomal protein S5, C-terminal domain +Ribosomal_S5_C PF03719.8 74 jgi|Monbr1|3220|gw1.3.602.1 - 144 9.9e-19 66.0 0.4 2 2 2.8e-22 1.7e-18 65.3 0.0 2 74 72 144 71 144 0.96 Ribosomal protein S5, C-terminal domain +Ribosomal_S5 PF00333.13 67 jgi|Monbr1|3220|gw1.3.602.1 - 144 2.6e-15 55.5 3.6 1 1 6.7e-19 4e-15 55.0 2.5 7 65 1 59 1 61 0.93 Ribosomal protein S5, N-terminal domain +Pkinase PF00069.18 260 jgi|Monbr1|3240|gw1.7.293.1 - 121 9.3e-23 80.3 0.0 1 1 3e-26 1.2e-22 80.0 0.0 103 198 4 112 2 114 0.89 Protein kinase domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|3240|gw1.7.293.1 - 121 7.4e-15 54.4 0.0 1 1 3.7e-18 1.5e-14 53.4 0.0 107 200 3 108 1 117 0.74 Protein tyrosine kinase +APH PF01636.16 238 jgi|Monbr1|3240|gw1.7.293.1 - 121 0.068 12.5 0.0 1 1 2.1e-05 0.084 12.2 0.0 165 185 18 38 5 54 0.78 Phosphotransferase enzyme family +7tm_2 PF00002.17 242 jgi|Monbr1|3267|gw1.2.830.1 - 139 1.2e-23 83.2 7.7 1 1 1.1e-26 1.4e-23 83.0 5.3 2 107 38 138 37 139 0.96 7 transmembrane receptor (Secretin family) +GPS PF01825.14 45 jgi|Monbr1|3267|gw1.2.830.1 - 139 1.4e-07 31.2 2.8 1 1 1.9e-10 2.3e-07 30.5 2.0 19 44 1 25 1 26 0.96 Latrophilin/CL-1-like GPS domain +DUF2231 PF09990.2 104 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.12 12.4 4.2 1 2 0.00046 0.54 10.3 0.7 43 91 47 93 19 95 0.74 Predicted membrane protein (DUF2231) +DUF2231 PF09990.2 104 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.12 12.4 4.2 2 2 0.00025 0.29 11.1 2.5 11 102 46 133 43 135 0.83 Predicted membrane protein (DUF2231) +Pox_P21 PF05313.5 190 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.14 11.0 2.6 1 1 0.00015 0.17 10.7 1.8 79 134 36 92 29 131 0.83 Poxvirus P21 membrane protein +Cyto_ox_2 PF02322.8 328 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.39 9.5 5.4 1 1 0.00038 0.45 9.3 3.7 177 276 21 120 9 135 0.74 Cytochrome oxidase subunit II +Herpes_LMP2 PF07415.4 489 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.82 7.8 5.4 1 1 0.00082 0.97 7.6 3.7 185 285 18 121 6 128 0.70 Gammaherpesvirus latent membrane protein (LMP2) protein +Frizzled PF01534.10 328 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.88 7.8 6.0 1 2 0.18 2.1e+02 0.0 0.9 165 202 57 94 37 97 0.64 Frizzled/Smoothened family membrane region +Frizzled PF01534.10 328 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.88 7.8 6.0 2 2 0.00012 0.14 10.5 0.3 87 114 96 123 91 136 0.82 Frizzled/Smoothened family membrane region +DUF2142 PF09913.2 389 jgi|Monbr1|3267|gw1.2.830.1 - 139 0.98 7.6 3.8 1 1 0.0012 1.4 7.1 2.6 179 256 20 93 13 138 0.61 Predicted membrane protein (DUF2142) +Adeno_E3_CR2 PF02439.8 38 jgi|Monbr1|3267|gw1.2.830.1 - 139 1.3 8.3 4.4 1 2 0.00049 0.58 9.4 0.4 10 31 46 67 41 72 0.88 Adenovirus E3 region protein CR2 +Adeno_E3_CR2 PF02439.8 38 jgi|Monbr1|3267|gw1.2.830.1 - 139 1.3 8.3 4.4 2 2 0.76 9e+02 -0.8 0.1 21 28 85 92 82 94 0.70 Adenovirus E3 region protein CR2 +Chromate_transp PF02417.8 169 jgi|Monbr1|3267|gw1.2.830.1 - 139 1.6 8.0 5.5 1 1 0.0022 2.6 7.2 3.8 78 152 46 119 34 135 0.77 Chromate transporter +Melibiase PF02065.11 394 jgi|Monbr1|3278|gw1.6.337.1 - 139 3.4e-05 22.4 0.1 1 1 3.5e-09 4.1e-05 22.1 0.1 39 125 4 107 2 129 0.85 Melibiase +LIM PF00412.15 58 jgi|Monbr1|3283|gw1.7.300.1 - 80 4.1e-15 55.2 3.3 1 1 3e-18 5.1e-15 54.9 2.3 1 57 1 56 1 57 0.96 LIM domain +zf-dskA_traR PF01258.10 36 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.014 14.8 0.3 1 2 0.22 3.8e+02 0.6 0.1 6 14 1 9 1 16 0.88 Prokaryotic dksA/traR C4-type zinc finger +zf-dskA_traR PF01258.10 36 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.014 14.8 0.3 2 2 4.9e-05 0.083 12.3 0.0 5 31 26 53 19 56 0.84 Prokaryotic dksA/traR C4-type zinc finger +DUF560 PF04575.6 304 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.033 12.9 0.0 1 1 2.2e-05 0.038 12.7 0.0 76 149 6 79 3 80 0.95 Protein of unknown function (DUF560) +TNFR_c6 PF00020.11 39 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.13 12.0 1.5 1 2 0.6 1e+03 -0.5 0.0 18 26 1 9 1 13 0.71 TNFR/NGFR cysteine-rich region +TNFR_c6 PF00020.11 39 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.13 12.0 1.5 2 2 0.00019 0.33 10.7 0.2 12 23 22 33 17 39 0.84 TNFR/NGFR cysteine-rich region +zf-C2H2 PF00096.19 23 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.22 11.7 2.2 1 3 0.19 3.2e+02 1.7 0.0 3 9 1 7 1 16 0.77 Zinc finger, C2H2 type +zf-C2H2 PF00096.19 23 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.22 11.7 2.2 2 3 0.011 18 5.7 0.1 1 9 26 34 26 37 0.86 Zinc finger, C2H2 type +zf-C2H2 PF00096.19 23 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.22 11.7 2.2 3 3 0.11 1.8e+02 2.5 0.1 5 12 48 55 47 63 0.86 Zinc finger, C2H2 type +DUF3330 PF11809.1 70 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.42 10.1 1.8 1 2 0.79 1.3e+03 -1.1 0.0 14 31 1 18 1 24 0.65 Domain of unknown function (DUF3330) +DUF3330 PF11809.1 70 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.42 10.1 1.8 2 2 0.00024 0.41 10.2 0.5 7 38 21 53 15 57 0.79 Domain of unknown function (DUF3330) +C1_1 PF00130.15 53 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.8 9.1 3.9 1 2 0.00082 1.4 8.4 1.5 14 38 1 35 1 38 0.83 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|3283|gw1.7.300.1 - 80 0.8 9.1 3.9 2 2 0.043 73 2.9 2.6 11 21 25 35 22 61 0.71 Phorbol esters/diacylglycerol binding domain (C1 domain) +Ank PF00023.23 33 jgi|Monbr1|3288|gw1.3.611.1 - 85 3.1e-16 57.9 4.3 1 3 2.8e-11 1.7e-07 30.3 0.1 2 32 9 39 8 40 0.94 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3288|gw1.3.611.1 - 85 3.1e-16 57.9 4.3 2 3 1.5e-10 8.9e-07 28.1 0.0 3 27 43 67 41 73 0.92 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3288|gw1.3.611.1 - 85 3.1e-16 57.9 4.3 3 3 0.13 8e+02 -0.2 0.2 2 10 77 85 76 85 0.89 Ankyrin repeat +Antibiotic_NAT PF02522.7 229 jgi|Monbr1|3288|gw1.3.611.1 - 85 0.11 11.4 0.3 1 2 0.047 2.8e+02 0.2 0.0 12 130 17 32 11 44 0.66 Aminoglycoside 3-N-acetyltransferase +Antibiotic_NAT PF02522.7 229 jgi|Monbr1|3288|gw1.3.611.1 - 85 0.11 11.4 0.3 2 2 8.3e-05 0.49 9.2 0.1 116 149 51 84 39 84 0.89 Aminoglycoside 3-N-acetyltransferase +CutC PF03932.7 202 jgi|Monbr1|3296|gw1.6.339.1 - 130 3.8e-46 156.5 0.2 1 1 3.5e-50 4.1e-46 156.4 0.2 3 130 1 128 1 130 0.99 CutC family +DSPc PF00782.13 133 jgi|Monbr1|3300|gw1.7.303.1 - 88 7.3e-27 93.2 0.0 1 1 1.3e-30 7.8e-27 93.1 0.0 44 130 2 88 1 88 0.97 Dual specificity phosphatase, catalytic domain +Y_phosphatase PF00102.20 235 jgi|Monbr1|3300|gw1.7.303.1 - 88 0.0001 21.4 0.0 1 1 1.8e-08 0.00011 21.3 0.0 154 194 20 55 8 73 0.78 Protein-tyrosine phosphatase +Kinesin PF00225.16 333 jgi|Monbr1|3301|gw1.3.618.1 - 156 7e-45 152.8 0.0 1 1 6.5e-49 7.8e-45 152.7 0.0 77 241 1 156 1 156 0.93 Kinesin motor domain +LicD PF04991.6 191 jgi|Monbr1|3312|gw1.7.304.1 - 125 6.5e-07 29.3 0.1 1 2 4.6e-06 0.054 13.2 0.2 18 41 1 24 1 32 0.95 LICD Protein Family +LicD PF04991.6 191 jgi|Monbr1|3312|gw1.7.304.1 - 125 6.5e-07 29.3 0.1 2 2 2.2e-06 0.026 14.3 0.0 164 191 98 125 47 125 0.76 LICD Protein Family +Ank PF00023.23 33 jgi|Monbr1|3317|gw1.2.838.1 - 95 1.3e-33 112.7 0.5 1 3 3e-13 1.2e-09 37.1 0.0 2 32 1 31 1 32 0.96 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3317|gw1.2.838.1 - 95 1.3e-33 112.7 0.5 2 3 2.4e-13 9.5e-10 37.4 0.0 2 32 34 64 33 65 0.96 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3317|gw1.2.838.1 - 95 1.3e-33 112.7 0.5 3 3 8.8e-13 3.5e-09 35.7 0.0 2 27 70 95 69 95 0.98 Ankyrin repeat +Shigella_OspC PF06128.4 284 jgi|Monbr1|3317|gw1.2.838.1 - 95 0.0015 17.7 0.1 1 3 0.35 1.4e+03 -1.8 0.0 258 278 5 25 1 29 0.78 Shigella flexneri OspC protein +Shigella_OspC PF06128.4 284 jgi|Monbr1|3317|gw1.2.838.1 - 95 0.0015 17.7 0.1 2 3 0.00014 0.58 9.3 0.0 250 280 30 60 18 64 0.87 Shigella flexneri OspC protein +Shigella_OspC PF06128.4 284 jgi|Monbr1|3317|gw1.2.838.1 - 95 0.0015 17.7 0.1 3 3 1.7e-05 0.069 12.3 0.0 229 278 46 94 45 95 0.93 Shigella flexneri OspC protein +SPAN PF02510.7 336 jgi|Monbr1|3317|gw1.2.838.1 - 95 0.09 11.4 0.3 1 2 0.00014 0.55 8.9 0.1 63 105 17 59 6 68 0.84 Surface presentation of antigens protein +SPAN PF02510.7 336 jgi|Monbr1|3317|gw1.2.838.1 - 95 0.09 11.4 0.3 2 2 0.0043 17 4.0 0.0 68 104 55 94 54 95 0.75 Surface presentation of antigens protein +Rieske PF00355.19 97 jgi|Monbr1|3327|gw1.4.482.1 - 109 9.6e-08 31.2 0.6 1 1 1.1e-11 1.4e-07 30.7 0.4 25 79 2 58 1 88 0.85 Rieske [2Fe-2S] domain +HSP20 PF00011.14 102 jgi|Monbr1|3340|gw1.8.345.1 - 105 1.8e-24 85.2 0.0 1 1 1.6e-28 2e-24 85.0 0.0 4 101 2 103 1 104 0.93 Hsp20/alpha crystallin family +Helicase_C PF00271.24 78 jgi|Monbr1|3344|gw1.3.627.1 - 102 1e-14 53.7 0.0 1 1 1.1e-18 1.3e-14 53.4 0.0 10 78 8 78 5 78 0.97 Helicase conserved C-terminal domain +UQ_con PF00179.19 140 jgi|Monbr1|3345|gw1.2.844.1 - 113 2.5e-35 120.5 0.2 1 1 4.5e-39 2.7e-35 120.4 0.1 23 132 4 113 1 113 0.94 Ubiquitin-conjugating enzyme +RWD PF05773.15 115 jgi|Monbr1|3345|gw1.2.844.1 - 113 0.099 12.2 0.2 1 1 3.2e-05 0.19 11.3 0.1 51 109 26 87 4 109 0.71 RWD domain +zf-C3HC4 PF00097.18 42 jgi|Monbr1|3354|gw1.7.309.1 - 91 2e-07 30.4 10.0 1 1 1.9e-10 3.7e-07 29.6 7.0 1 42 1 40 1 40 0.97 Zinc finger, C3HC4 type (RING finger) +zf-Nse PF11789.1 57 jgi|Monbr1|3354|gw1.7.309.1 - 91 0.037 13.2 8.0 1 1 3e-05 0.059 12.5 5.5 14 56 1 40 1 45 0.95 Zinc-finger of the MIZ type in Nse subunit +Baculo_LEF5_C PF11792.1 43 jgi|Monbr1|3354|gw1.7.309.1 - 91 0.04 12.9 0.1 1 2 2e-05 0.04 12.9 0.1 6 25 10 31 7 34 0.90 Baculoviridae late expression factor 5 C-terminal domain +Baculo_LEF5_C PF11792.1 43 jgi|Monbr1|3354|gw1.7.309.1 - 91 0.04 12.9 0.1 2 2 2 3.9e+03 -3.0 0.2 36 41 36 41 35 43 0.69 Baculoviridae late expression factor 5 C-terminal domain +Ribonuclease_T2 PF00445.11 189 jgi|Monbr1|3354|gw1.7.309.1 - 91 0.075 12.3 0.6 1 1 4e-05 0.079 12.2 0.4 18 56 40 84 16 91 0.65 Ribonuclease T2 family +zf-MIZ PF02891.13 50 jgi|Monbr1|3354|gw1.7.309.1 - 91 1.3 8.2 6.6 1 1 0.0013 2.5 7.3 4.6 5 49 1 42 1 43 0.93 MIZ/SP-RING zinc finger +DUF1272 PF06906.4 57 jgi|Monbr1|3354|gw1.7.309.1 - 91 1.6 8.3 7.2 1 1 0.0017 3.3 7.3 5.0 29 49 19 42 1 50 0.73 Protein of unknown function (DUF1272) +UQ_con PF00179.19 140 jgi|Monbr1|3366|gw1.4.490.1 - 110 9.2e-27 92.8 0.1 1 1 1.7e-30 9.9e-27 92.7 0.1 23 132 4 110 1 110 0.95 Ubiquitin-conjugating enzyme +RWD PF05773.15 115 jgi|Monbr1|3366|gw1.4.490.1 - 110 0.0012 18.4 0.1 1 1 2e-07 0.0012 18.4 0.1 51 73 25 47 8 91 0.88 RWD domain +RRM_1 PF00076.15 70 jgi|Monbr1|3397|gw1.3.632.1 - 77 3.1e-16 58.4 0.0 1 1 2.8e-20 3.3e-16 58.3 0.0 1 68 6 74 6 76 0.96 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +CH PF00307.24 109 jgi|Monbr1|3432|gw1.7.316.1 - 73 5.7e-13 48.4 0.1 1 1 1.6e-16 6.2e-13 48.3 0.0 25 97 1 72 1 73 0.87 Calponin homology (CH) domain +CDC24 PF06395.4 89 jgi|Monbr1|3432|gw1.7.316.1 - 73 0.0011 18.6 0.0 1 1 3.2e-07 0.0013 18.5 0.0 9 73 5 66 1 72 0.85 CDC24 Calponin +CAMSAP_CH PF11971.1 85 jgi|Monbr1|3432|gw1.7.316.1 - 73 0.005 16.1 0.0 1 1 1.5e-06 0.0058 15.9 0.0 15 68 1 50 1 65 0.86 CAMSAP CH domain +Trypan_PARP PF05887.4 143 jgi|Monbr1|3434|gw1.5.408.1 - 72 0.0037 16.7 19.0 1 1 6.9e-07 0.0041 16.6 13.1 60 122 5 67 1 72 0.35 Procyclic acidic repetitive protein (PARP) +Cytadhesin_P30 PF07271.4 279 jgi|Monbr1|3434|gw1.5.408.1 - 72 0.078 11.9 1.4 1 1 1.4e-05 0.085 11.8 1.0 203 242 24 69 3 72 0.33 Cytadhesin P30/P32 +LSM PF01423.15 68 jgi|Monbr1|3442|gw1.6.354.1 - 73 2.1e-18 65.2 0.0 1 1 2e-22 2.3e-18 65.0 0.0 7 64 3 65 1 69 0.94 LSM domain +Ank PF00023.23 33 jgi|Monbr1|3444|gw1.2.866.1 - 99 4.2e-30 101.7 1.2 1 3 1.3e-12 1.5e-08 33.6 0.1 2 29 1 28 1 31 0.96 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3444|gw1.2.866.1 - 99 4.2e-30 101.7 1.2 2 3 1.3e-13 1.5e-09 36.8 0.0 2 32 34 64 33 65 0.96 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3444|gw1.2.866.1 - 99 4.2e-30 101.7 1.2 3 3 3e-11 3.6e-07 29.3 0.0 3 33 68 99 67 99 0.95 Ankyrin repeat +MORN PF02493.13 23 jgi|Monbr1|3462|gw1.5.415.1 - 89 2.5e-27 92.6 33.0 1 4 4.8e-12 5.7e-08 31.7 0.9 1 22 7 28 7 29 0.96 MORN repeat +MORN PF02493.13 23 jgi|Monbr1|3462|gw1.5.415.1 - 89 2.5e-27 92.6 33.0 2 4 1.5e-11 1.8e-07 30.1 0.7 1 22 30 51 30 52 0.97 MORN repeat +MORN PF02493.13 23 jgi|Monbr1|3462|gw1.5.415.1 - 89 2.5e-27 92.6 33.0 3 4 1.5e-11 1.8e-07 30.1 1.7 1 23 53 75 53 75 0.96 MORN repeat +MORN PF02493.13 23 jgi|Monbr1|3462|gw1.5.415.1 - 89 2.5e-27 92.6 33.0 4 4 9e-08 0.0011 18.2 4.3 1 14 76 89 76 89 0.99 MORN repeat +RRM_1 PF00076.15 70 jgi|Monbr1|3477|gw1.6.358.1 - 86 1.2e-21 75.8 0.0 1 1 3.3e-25 1.3e-21 75.6 0.0 3 70 6 74 4 74 0.97 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +Limkain-b1 PF11608.1 91 jgi|Monbr1|3477|gw1.6.358.1 - 86 0.072 12.5 0.2 1 1 2.8e-05 0.11 11.9 0.1 42 78 46 82 37 85 0.87 Limkain b1 +RRM_3 PF08777.4 105 jgi|Monbr1|3477|gw1.6.358.1 - 86 0.093 12.2 0.0 1 1 3.3e-05 0.13 11.8 0.0 6 61 6 68 2 82 0.68 RNA binding motif +AhpC-TSA PF00578.14 124 jgi|Monbr1|3489|gw1.4.513.1 - 106 4.8e-15 55.0 0.0 1 1 3.1e-18 5.2e-15 54.9 0.0 26 123 2 99 1 100 0.93 AhpC/TSA family +Redoxin PF08534.3 146 jgi|Monbr1|3489|gw1.4.513.1 - 106 2.4e-14 52.8 0.0 1 1 1.5e-17 2.5e-14 52.7 0.0 29 134 2 104 1 106 0.90 Redoxin +Thioredoxin PF00085.13 104 jgi|Monbr1|3489|gw1.4.513.1 - 106 1.8e-09 36.9 0.4 1 2 3.2e-12 5.5e-09 35.3 0.4 20 55 3 39 1 56 0.82 Thioredoxin +Thioredoxin PF00085.13 104 jgi|Monbr1|3489|gw1.4.513.1 - 106 1.8e-09 36.9 0.4 2 2 0.42 7.1e+02 -0.4 0.0 57 82 69 94 43 103 0.69 Thioredoxin +GSHPx PF00255.12 108 jgi|Monbr1|3489|gw1.4.513.1 - 106 0.014 14.4 0.0 1 1 1e-05 0.017 14.1 0.0 22 81 2 55 1 78 0.74 Glutathione peroxidase +DUF899 PF05988.5 211 jgi|Monbr1|3489|gw1.4.513.1 - 106 0.088 11.9 0.0 1 1 5.8e-05 0.098 11.7 0.0 81 147 9 76 3 100 0.78 Bacterial protein of unknown function (DUF899) +Isochorismatase PF00857.13 174 jgi|Monbr1|3489|gw1.4.513.1 - 106 0.1 12.2 0.0 1 1 7.4e-05 0.13 11.9 0.0 13 51 13 45 2 88 0.79 Isochorismatase family +Glutaredoxin PF00462.17 60 jgi|Monbr1|3489|gw1.4.513.1 - 106 0.13 11.9 0.1 1 2 0.2 3.5e+02 0.9 0.3 7 15 11 19 4 44 0.72 Glutaredoxin +Glutaredoxin PF00462.17 60 jgi|Monbr1|3489|gw1.4.513.1 - 106 0.13 11.9 0.1 2 2 0.00058 0.98 9.1 0.0 10 54 44 89 35 96 0.85 Glutaredoxin +zf-C2H2 PF00096.19 23 jgi|Monbr1|3492|gw1.6.360.1 - 78 0.0022 18.0 3.0 1 2 7.4e-07 0.0022 18.0 2.1 1 23 8 31 8 31 0.95 Zinc finger, C2H2 type +zf-C2H2 PF00096.19 23 jgi|Monbr1|3492|gw1.6.360.1 - 78 0.0022 18.0 3.0 2 2 0.12 3.4e+02 1.6 0.4 1 21 45 67 45 71 0.72 Zinc finger, C2H2 type +zf-C2H2_jaz PF12171.1 27 jgi|Monbr1|3492|gw1.6.360.1 - 78 0.04 13.7 2.4 1 2 1.9e-05 0.058 13.2 0.9 1 22 7 28 7 29 0.93 Zinc-finger double-stranded RNA-binding +zf-C2H2_jaz PF12171.1 27 jgi|Monbr1|3492|gw1.6.360.1 - 78 0.04 13.7 2.4 2 2 1.1 3.2e+03 -1.9 0.0 12 21 57 66 51 67 0.73 Zinc-finger double-stranded RNA-binding +FYVE PF01363.14 69 jgi|Monbr1|3492|gw1.6.360.1 - 78 0.26 10.9 2.8 1 1 0.00017 0.5 9.9 1.9 24 46 6 28 2 70 0.55 FYVE zinc finger +GFA PF04828.7 92 jgi|Monbr1|3492|gw1.6.360.1 - 78 1.9 8.1 4.2 1 2 0.0051 15 5.2 0.4 45 59 4 18 1 26 0.82 Glutathione-dependent formaldehyde-activating enzyme +GFA PF04828.7 92 jgi|Monbr1|3492|gw1.6.360.1 - 78 1.9 8.1 4.2 2 2 0.0053 16 5.1 0.1 40 68 38 66 16 71 0.68 Glutathione-dependent formaldehyde-activating enzyme +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|3505|gw1.3.654.1 - 85 1.9e-25 89.1 0.1 1 1 3.5e-29 2.1e-25 89.0 0.1 169 250 4 85 1 85 0.98 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|3505|gw1.3.654.1 - 85 2e-09 36.6 0.0 1 1 4e-13 2.4e-09 36.4 0.0 163 249 5 85 3 85 0.81 Protein kinase domain +Ank PF00023.23 33 jgi|Monbr1|3506|gw1.6.363.1 - 101 2.1e-16 58.5 0.0 1 3 9.9e-10 5.9e-06 25.5 0.0 2 33 17 48 16 48 0.97 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3506|gw1.6.363.1 - 101 2.1e-16 58.5 0.0 2 3 3e-09 1.8e-05 23.9 0.0 1 23 49 71 49 74 0.94 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3506|gw1.6.363.1 - 101 2.1e-16 58.5 0.0 3 3 0.0016 9.5 5.9 0.0 3 17 87 101 85 101 0.90 Ankyrin repeat +DUF2336 PF10098.2 262 jgi|Monbr1|3506|gw1.6.363.1 - 101 0.065 12.1 0.0 1 1 1.4e-05 0.084 11.7 0.0 150 191 3 44 1 50 0.92 Uncharacterized protein conserved in bacteria (DUF2336) +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|3511|gw1.4.516.1 - 84 3.4e-24 85.0 0.0 1 1 6.3e-28 3.8e-24 84.9 0.0 168 251 1 84 1 84 0.99 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|3511|gw1.4.516.1 - 84 0.00026 19.9 0.0 1 1 5.2e-08 0.00031 19.6 0.0 163 250 3 84 2 84 0.78 Protein kinase domain +FHA PF00498.19 68 jgi|Monbr1|3524|gw1.4.518.1 - 92 4.1e-13 48.8 0.0 1 1 4.2e-17 5e-13 48.6 0.0 1 68 19 86 19 86 0.96 FHA domain +DnaJ PF00226.24 64 jgi|Monbr1|3526|gw1.8.361.1 - 65 1.5e-23 81.9 0.3 1 1 4.1e-27 1.6e-23 81.8 0.2 1 64 2 64 2 64 0.99 DnaJ domain +HTH_10 PF04967.5 53 jgi|Monbr1|3526|gw1.8.361.1 - 65 0.012 14.8 0.0 1 1 4.6e-06 0.018 14.2 0.0 31 52 5 26 3 27 0.94 HTH DNA binding domain +Adap_comp_sub PF00928.14 263 jgi|Monbr1|3526|gw1.8.361.1 - 65 0.086 11.6 0.0 1 1 2.5e-05 0.1 11.4 0.0 8 30 36 58 28 62 0.83 Adaptor complexes medium subunit family +Evr1_Alr PF04777.6 97 jgi|Monbr1|3541|gw1.7.320.1 - 111 5e-28 96.5 0.0 1 1 4.9e-32 5.8e-28 96.3 0.0 2 96 11 102 10 103 0.96 Erv1 / Alr family +Metallophos PF00149.21 200 jgi|Monbr1|3574|gw1.3.671.1 - 112 4.3e-07 29.2 1.7 1 1 8.8e-11 5.3e-07 28.9 1.1 136 200 43 112 6 112 0.85 Calcineurin-like phosphoesterase +UPF0054 PF02130.10 145 jgi|Monbr1|3574|gw1.3.671.1 - 112 0.0087 15.0 0.5 1 1 2.3e-06 0.013 14.4 0.3 91 140 40 92 37 97 0.78 Uncharacterized protein family UPF0054 +Bromodomain PF00439.18 84 jgi|Monbr1|3578|gw1.3.673.1 - 72 2.1e-19 68.9 0.0 1 1 1.8e-23 2.2e-19 68.8 0.0 3 68 7 72 5 72 0.96 Bromodomain +ArfGap PF01412.11 117 jgi|Monbr1|3591|gw1.8.364.1 - 95 2.9e-37 126.7 0.0 1 1 5.4e-41 3.2e-37 126.5 0.0 13 108 1 95 1 95 0.97 Putative GTPase activating protein for Arf +A2L_zn_ribbon PF08792.3 33 jgi|Monbr1|3591|gw1.8.364.1 - 95 0.15 11.2 0.7 1 1 6.3e-05 0.38 9.9 0.5 5 29 3 29 1 32 0.89 A2L zinc ribbon domain +Ank PF00023.23 33 jgi|Monbr1|3592|gw1.8.365.1 - 63 7.1e-23 78.9 0.3 1 2 1.8e-15 2.2e-11 42.6 0.0 2 32 1 31 1 32 0.96 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|3592|gw1.8.365.1 - 63 7.1e-23 78.9 0.3 2 2 4.8e-13 5.7e-09 35.0 0.0 2 31 34 63 33 63 0.94 Ankyrin repeat +DnaJ PF00226.24 64 jgi|Monbr1|3605|gw1.2.899.1 - 64 3.2e-25 87.3 1.0 1 1 5.8e-29 3.5e-25 87.2 0.7 1 64 1 63 1 63 0.99 DnaJ domain +RED_N PF07808.6 238 jgi|Monbr1|3605|gw1.2.899.1 - 64 0.22 10.3 1.0 1 1 3.9e-05 0.23 10.3 0.7 12 49 9 45 1 63 0.76 RED-like protein N-terminal region +RRM_1 PF00076.15 70 jgi|Monbr1|3616|gw1.6.378.1 - 71 1.1e-18 66.2 0.0 1 1 1e-22 1.2e-18 66.1 0.0 1 70 2 71 2 71 0.96 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +zf-C3HC4 PF00097.18 42 jgi|Monbr1|3618|gw1.4.537.1 - 58 7.3e-06 25.4 5.0 1 1 9.4e-09 9.4e-06 25.1 3.5 1 42 12 52 12 52 0.93 Zinc finger, C3HC4 type (RING finger) +Di19 PF05605.5 211 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.032 13.4 2.6 1 1 3.9e-05 0.039 13.1 1.8 31 70 6 53 4 57 0.80 Drought induced 19 protein (Di19) +zf-P11 PF03854.7 50 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.048 12.8 3.8 1 2 0.015 15 4.8 0.0 31 41 5 15 2 19 0.82 P-11 zinc finger +zf-P11 PF03854.7 50 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.048 12.8 3.8 2 2 0.00085 0.84 8.8 0.9 25 47 36 58 27 58 0.85 P-11 zinc finger +zf-Nse PF11789.1 57 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.06 12.5 2.2 1 1 8e-05 0.08 12.1 1.5 9 56 7 52 3 53 0.88 Zinc-finger of the MIZ type in Nse subunit +zf-Sec23_Sec24 PF04810.8 40 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.07 12.4 0.2 1 2 0.014 14 5.1 0.0 23 31 8 16 5 24 0.82 Sec23/Sec24 zinc finger +zf-Sec23_Sec24 PF04810.8 40 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.07 12.4 0.2 2 2 0.0086 8.5 5.7 0.0 26 32 48 54 39 57 0.78 Sec23/Sec24 zinc finger +Vps39_2 PF10367.2 109 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.079 12.8 1.4 1 2 0.00016 0.16 11.8 0.2 75 109 6 41 1 41 0.89 Vacuolar sorting protein 39 domain 2 +Vps39_2 PF10367.2 109 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.079 12.8 1.4 2 2 0.56 5.6e+02 0.4 0.0 76 88 44 56 42 58 0.76 Vacuolar sorting protein 39 domain 2 +PHD PF00628.22 51 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.1 11.9 4.5 1 1 0.00017 0.17 11.3 3.1 1 49 11 53 11 55 0.87 PHD-finger +Rad50_zn_hook PF04423.7 54 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.11 11.7 0.2 1 2 0.011 11 5.3 0.0 21 31 10 20 2 28 0.74 Rad50 zinc hook motif +Rad50_zn_hook PF04423.7 54 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.11 11.7 0.2 2 2 0.014 14 4.9 0.0 19 30 46 56 42 58 0.74 Rad50 zinc hook motif +Transposase_35 PF07282.4 69 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.42 9.9 1.8 1 2 0.15 1.5e+02 1.8 0.2 30 50 11 31 8 40 0.66 Putative transposase DNA-binding domain +Transposase_35 PF07282.4 69 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.42 9.9 1.8 2 2 0.0019 1.9 7.8 0.1 22 38 39 56 34 58 0.84 Putative transposase DNA-binding domain +zf-RING-like PF08746.4 43 jgi|Monbr1|3618|gw1.4.537.1 - 58 0.43 10.3 7.8 1 1 0.0013 1.2 8.8 5.4 22 43 18 52 3 52 0.69 RING-like domain +C1_1 PF00130.15 53 jgi|Monbr1|3618|gw1.4.537.1 - 58 1.4 8.4 4.1 1 2 0.003 2.9 7.3 0.9 9 46 7 42 3 47 0.83 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|3618|gw1.4.537.1 - 58 1.4 8.4 4.1 2 2 0.026 26 4.3 0.1 5 21 40 56 39 58 0.84 Phorbol esters/diacylglycerol binding domain (C1 domain) +FANCL_C PF11793.1 70 jgi|Monbr1|3618|gw1.4.537.1 - 58 1.5 8.5 5.3 1 2 0.00071 0.71 9.5 1.0 2 43 9 45 8 48 0.77 FANCL C-terminal domain +FANCL_C PF11793.1 70 jgi|Monbr1|3618|gw1.4.537.1 - 58 1.5 8.5 5.3 2 2 0.62 6.1e+02 0.1 0.1 58 64 49 55 42 58 0.74 FANCL C-terminal domain +DnaJ PF00226.24 64 jgi|Monbr1|3642|gw1.8.368.1 - 68 1.3e-17 62.9 0.0 1 1 1.2e-21 1.4e-17 62.8 0.0 2 64 3 68 2 68 0.97 DnaJ domain +SUI1 PF01253.15 83 jgi|Monbr1|3654|gw1.2.915.1 - 75 1.7e-23 81.8 0.1 1 1 1.6e-27 1.9e-23 81.7 0.1 11 82 1 71 1 72 0.94 Translation initiation factor SUI1 +Ribosomal_S26e PF01283.12 114 jgi|Monbr1|3665|gw1.6.388.1 - 93 1.1e-44 150.9 9.5 1 1 2e-48 1.2e-44 150.8 6.6 3 95 1 93 1 93 0.99 Ribosomal protein S26e +DUF164 PF02591.8 56 jgi|Monbr1|3665|gw1.6.388.1 - 93 0.52 9.8 2.4 1 2 5.6e-05 0.33 10.4 0.2 41 54 13 26 5 28 0.82 Putative zinc ribbon domain +DUF164 PF02591.8 56 jgi|Monbr1|3665|gw1.6.388.1 - 93 0.52 9.8 2.4 2 2 0.56 3.3e+03 -2.4 0.1 46 52 69 75 66 78 0.61 Putative zinc ribbon domain +Fork_head PF00250.11 96 jgi|Monbr1|3671|gw1.3.684.1 - 96 1e-34 118.1 0.0 1 1 9.3e-39 1.1e-34 117.9 0.0 1 94 1 95 1 96 0.95 Fork head domain +PH PF00169.22 104 jgi|Monbr1|3675|gw1.2.921.1 - 50 0.00011 22.0 0.1 1 1 9.2e-09 0.00011 22.0 0.0 4 37 7 40 5 50 0.87 PH domain +Pterin_4a PF01329.12 96 jgi|Monbr1|3695|gw1.5.441.1 - 97 9.8e-33 111.4 0.2 1 1 8.8e-37 1e-32 111.3 0.1 4 95 3 97 1 97 0.91 Pterin 4 alpha carbinolamine dehydratase +SRF-TF PF00319.11 51 jgi|Monbr1|3712|gw1.4.553.1 - 62 1.2e-08 33.7 0.1 1 1 1.1e-12 1.3e-08 33.5 0.1 3 51 2 50 1 50 0.92 SRF-type transcription factor (DNA-binding and dimerisation domain) +NOT2_3_5 PF04153.11 131 jgi|Monbr1|3714|gw1.7.330.1 - 91 4e-35 120.2 11.8 1 1 1.1e-38 4.3e-35 120.1 8.2 44 131 2 90 1 90 0.98 NOT2 / NOT3 / NOT5 family +DUF2373 PF10180.2 65 jgi|Monbr1|3714|gw1.7.330.1 - 91 0.018 14.2 2.5 1 1 7.1e-06 0.028 13.6 1.8 2 28 25 51 24 71 0.84 Uncharacterised conserved protein (DUF2373) +DUF718 PF05336.6 106 jgi|Monbr1|3714|gw1.7.330.1 - 91 0.052 13.0 0.2 1 1 1.8e-05 0.07 12.6 0.1 42 88 3 48 2 63 0.82 Domain of unknown function (DUF718) +CAP_GLY PF01302.18 69 jgi|Monbr1|3717|gw1.2.928.1 - 50 2.5e-19 68.4 0.1 1 1 2.1e-23 2.6e-19 68.3 0.1 17 65 3 50 1 50 0.95 CAP-Gly domain +HMG_box PF00505.12 69 jgi|Monbr1|3720|gw1.7.333.1 - 75 2e-19 69.4 0.7 1 1 3.8e-23 2.3e-19 69.3 0.5 1 68 4 71 4 72 0.99 HMG (high mobility group) box +KfrA_N PF11740.1 120 jgi|Monbr1|3720|gw1.7.333.1 - 75 0.028 14.5 1.4 1 1 5.3e-06 0.032 14.3 1.0 43 107 13 74 4 75 0.69 Plasmid replication region DNA-binding N-term +Bromodomain PF00439.18 84 jgi|Monbr1|3721|gw1.2.929.1 - 63 5.4e-18 64.3 0.1 1 1 4.8e-22 5.7e-18 64.2 0.1 17 77 1 61 1 63 0.97 Bromodomain +Rad60-SLD PF11976.1 72 jgi|Monbr1|3727|gw1.3.689.1 - 55 7.3e-08 31.6 0.0 1 1 7.2e-12 8.5e-08 31.4 0.0 15 68 1 53 1 54 0.98 Ubiquitin-2 like Rad60 SUMO-like +RRM_1 PF00076.15 70 jgi|Monbr1|3751|gw1.3.694.1 - 77 2.5e-20 71.5 0.0 1 1 7.5e-24 3e-20 71.3 0.0 11 69 2 61 1 62 0.97 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +Limkain-b1 PF11608.1 91 jgi|Monbr1|3751|gw1.3.694.1 - 77 0.015 14.7 0.1 1 1 5.1e-06 0.02 14.2 0.0 43 74 35 66 30 73 0.89 Limkain b1 +Sbi-IV PF11621.1 69 jgi|Monbr1|3751|gw1.3.694.1 - 77 0.027 14.2 0.0 1 1 9e-06 0.036 13.9 0.0 12 33 39 60 35 69 0.82 C3 binding domain 4 of IgG-bind protein SBI +CAP_GLY PF01302.18 69 jgi|Monbr1|3756|gw1.6.406.1 - 68 1.6e-25 88.2 0.7 1 1 1.4e-29 1.7e-25 88.1 0.5 2 68 4 68 3 68 0.96 CAP-Gly domain +Fork_head PF00250.11 96 jgi|Monbr1|3759|gw1.5.447.1 - 83 1.4e-27 95.2 0.0 1 1 1.2e-31 1.5e-27 95.1 0.0 1 81 1 81 1 83 0.97 Fork head domain +zf-C2H2 PF00096.19 23 jgi|Monbr1|3760|gw1.2.938.1 - 72 4.8e-09 35.8 21.1 1 3 0.0013 3.9 7.8 0.6 10 23 1 14 1 14 0.94 Zinc finger, C2H2 type +zf-C2H2 PF00096.19 23 jgi|Monbr1|3760|gw1.2.938.1 - 72 4.8e-09 35.8 21.1 2 3 4.3e-07 0.0013 18.7 4.0 1 23 20 42 20 42 0.98 Zinc finger, C2H2 type +zf-C2H2 PF00096.19 23 jgi|Monbr1|3760|gw1.2.938.1 - 72 4.8e-09 35.8 21.1 3 3 1.7e-07 0.0005 20.0 0.6 1 23 48 72 48 72 0.95 Zinc finger, C2H2 type +zf-C2H2_jaz PF12171.1 27 jgi|Monbr1|3760|gw1.2.938.1 - 72 0.031 14.1 9.6 1 3 2.1 6.1e+03 -2.8 0.0 17 20 7 10 2 11 0.54 Zinc-finger double-stranded RNA-binding +zf-C2H2_jaz PF12171.1 27 jgi|Monbr1|3760|gw1.2.938.1 - 72 0.031 14.1 9.6 2 3 0.00011 0.31 10.9 1.8 2 24 20 42 19 43 0.94 Zinc-finger double-stranded RNA-binding +zf-C2H2_jaz PF12171.1 27 jgi|Monbr1|3760|gw1.2.938.1 - 72 0.031 14.1 9.6 3 3 0.0011 3.3 7.6 0.0 7 24 55 72 53 72 0.92 Zinc-finger double-stranded RNA-binding +IBR PF01485.14 64 jgi|Monbr1|3760|gw1.2.938.1 - 72 0.26 10.9 1.4 1 2 0.036 1.1e+02 2.5 0.1 38 49 18 28 4 31 0.74 IBR domain +IBR PF01485.14 64 jgi|Monbr1|3760|gw1.2.938.1 - 72 0.26 10.9 1.4 2 2 0.00062 1.9 8.1 0.1 11 35 38 64 27 70 0.68 IBR domain +zf-TRAF PF02176.11 60 jgi|Monbr1|3760|gw1.2.938.1 - 72 0.5 10.4 5.5 1 1 0.00016 0.47 10.5 3.3 11 54 21 61 10 68 0.81 TRAF-type zinc finger +Histone PF00125.17 75 jgi|Monbr1|3764|gw1.6.408.1 - 87 1.9e-29 101.3 0.0 1 1 3.5e-33 2.1e-29 101.1 0.0 1 75 8 81 8 81 0.98 Core histone H2A/H2B/H3/H4 +CBFD_NFYB_HMF PF00808.16 65 jgi|Monbr1|3764|gw1.6.408.1 - 87 3.5e-07 29.8 0.0 1 1 6.9e-11 4.1e-07 29.6 0.0 2 65 15 78 14 78 0.98 Histone-like transcription factor (CBF/NF-Y) and archaeal histone +Tudor-knot PF11717.1 55 jgi|Monbr1|3766|gw1.6.409.1 - 50 0.012 14.9 0.2 1 1 2.1e-06 0.013 14.8 0.1 34 50 28 44 8 49 0.87 RNA binding activity-knot of a chromodomain +MBT PF02820.11 73 jgi|Monbr1|3766|gw1.6.409.1 - 50 0.039 13.5 0.0 1 1 7e-06 0.042 13.4 0.0 15 44 13 44 5 49 0.82 mbt repeat +zf-CSL PF05207.6 57 jgi|Monbr1|3774|gw1.2.941.1 - 66 4.3e-25 86.7 2.2 1 1 8.1e-29 4.8e-25 86.5 1.5 1 57 6 60 6 60 0.99 CSL zinc finger +CxxC_CxxC_SSSS PF09723.3 42 jgi|Monbr1|3774|gw1.2.941.1 - 66 0.43 10.2 2.0 1 1 0.00018 1.1 8.9 1.4 4 34 22 53 21 59 0.66 Zinc ribbon domain +COX6B PF02297.10 71 jgi|Monbr1|3788|gw1.5.452.1 - 61 1.3e-18 66.4 5.0 1 1 6.6e-22 1.3e-18 66.4 3.5 7 68 3 60 1 61 0.95 Cytochrome oxidase c subunit VIb +Pet191_N PF10203.2 68 jgi|Monbr1|3788|gw1.5.452.1 - 61 0.0045 16.6 1.0 1 1 3.1e-06 0.0061 16.2 0.7 17 55 4 41 3 54 0.80 Cytochrome c oxidase assembly protein PET191 +CHCH PF06747.6 35 jgi|Monbr1|3788|gw1.5.452.1 - 61 0.021 14.4 0.7 1 1 2.1e-05 0.042 13.4 0.5 7 29 14 36 13 43 0.86 CHCH domain +DUF982 PF06169.5 76 jgi|Monbr1|3788|gw1.5.452.1 - 61 0.12 11.7 0.4 1 1 0.00011 0.22 10.9 0.3 51 71 24 44 2 47 0.88 Protein of unknown function (DUF982) +DUF1903 PF08991.3 63 jgi|Monbr1|3788|gw1.5.452.1 - 61 0.16 11.7 1.2 1 1 0.0001 0.2 11.3 0.8 3 36 7 40 2 54 0.76 Domain of unknown function (DUF1903) +UPF0203 PF05254.5 68 jgi|Monbr1|3788|gw1.5.452.1 - 61 0.49 9.9 3.4 1 2 0.00084 1.7 8.2 0.3 34 51 4 21 1 27 0.76 Uncharacterised protein family (UPF0203) +UPF0203 PF05254.5 68 jgi|Monbr1|3788|gw1.5.452.1 - 61 0.49 9.9 3.4 2 2 0.026 52 3.4 0.1 6 24 26 45 21 56 0.74 Uncharacterised protein family (UPF0203) +zf-C3HC4 PF00097.18 42 jgi|Monbr1|3794|gw1.5.454.1 - 53 3.2e-10 39.4 9.5 1 1 2.2e-13 3.7e-10 39.2 6.6 1 42 5 45 5 45 0.97 Zinc finger, C3HC4 type (RING finger) +FANCL_C PF11793.1 70 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.01 15.4 10.3 1 1 4.1e-05 0.07 12.7 7.1 3 46 3 41 1 53 0.89 FANCL C-terminal domain +PHD PF00628.22 51 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.032 13.6 7.8 1 2 4.1e-05 0.07 12.5 5.5 2 49 5 46 4 48 0.84 PHD-finger +PHD PF00628.22 51 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.032 13.6 7.8 2 2 0.17 2.9e+02 0.9 0.1 1 7 41 47 41 51 0.70 PHD-finger +zf-Nse PF11789.1 57 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.048 12.8 4.1 1 1 4.9e-05 0.084 12.1 2.9 13 57 4 46 2 46 0.84 Zinc-finger of the MIZ type in Nse subunit +Baculo_RING PF05883.4 135 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.091 12.2 4.7 1 1 9.1e-05 0.16 11.5 3.2 28 74 4 44 2 52 0.84 Baculovirus U-box/Ring-like domain +Rad50_zn_hook PF04423.7 54 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.41 9.9 0.1 1 2 0.66 1.1e+03 -1.1 0.2 22 33 4 15 1 18 0.57 Rad50 zinc hook motif +Rad50_zn_hook PF04423.7 54 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.41 9.9 0.1 2 2 0.00024 0.41 9.9 0.1 17 29 37 48 35 52 0.82 Rad50 zinc hook motif +zf-P11 PF03854.7 50 jgi|Monbr1|3794|gw1.5.454.1 - 53 0.86 8.8 7.5 1 1 0.00076 1.3 8.2 5.2 5 43 8 47 2 53 0.77 P-11 zinc finger +PHD PF00628.22 51 jgi|Monbr1|3799|gw1.4.564.1 - 55 3.9e-13 48.5 7.8 1 1 2.6e-16 4.5e-13 48.3 5.4 1 48 6 55 6 55 0.96 PHD-finger +Terminase_GpA PF05876.5 557 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.017 13.2 3.3 1 1 1.1e-05 0.018 13.1 2.3 195 235 13 55 8 55 0.83 Phage terminase large subunit (GpA) +C1_1 PF00130.15 53 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.02 14.3 1.1 1 2 1.2e-05 0.02 14.3 0.8 24 45 14 35 5 42 0.84 Phorbol esters/diacylglycerol binding domain (C1 domain) +C1_1 PF00130.15 53 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.02 14.3 1.1 2 2 0.23 4e+02 0.5 0.2 25 34 46 55 39 55 0.75 Phorbol esters/diacylglycerol binding domain (C1 domain) +zf-RING-like PF08746.4 43 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.062 13.0 7.2 1 1 0.00038 0.65 9.7 5.0 12 43 19 55 16 55 0.71 RING-like domain +zf-C3HC4 PF00097.18 42 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.17 11.4 5.0 1 1 0.00015 0.26 10.9 3.5 3 42 8 55 5 55 0.78 Zinc finger, C3HC4 type (RING finger) +FANCL_C PF11793.1 70 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.39 10.4 4.8 1 1 0.00029 0.49 10.0 3.3 7 61 6 55 1 55 0.74 FANCL C-terminal domain +C1_4 PF07975.5 51 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.65 9.7 8.4 1 2 0.00093 1.6 8.5 1.4 20 35 17 32 8 35 0.87 TFIIH C1-like domain +C1_4 PF07975.5 51 jgi|Monbr1|3799|gw1.4.564.1 - 55 0.65 9.7 8.4 2 2 0.0065 11 5.8 0.2 11 27 39 55 33 55 0.70 TFIIH C1-like domain +SH3_1 PF00018.21 48 jgi|Monbr1|3808|gw1.5.458.1 - 53 4.5e-15 54.4 0.1 1 1 1.2e-18 4.9e-15 54.3 0.1 1 46 2 45 2 47 0.96 SH3 domain +SH3_2 PF07653.10 55 jgi|Monbr1|3808|gw1.5.458.1 - 53 3.3e-10 39.0 0.0 1 1 8.6e-14 3.4e-10 38.9 0.0 3 49 2 47 1 52 0.86 Variant SH3 domain +SH3_3 PF08239.4 52 jgi|Monbr1|3808|gw1.5.458.1 - 53 0.025 13.9 0.0 1 1 7.4e-06 0.029 13.7 0.0 18 52 16 51 9 51 0.90 Bacterial SH3 domain +UBA PF00627.24 37 jgi|Monbr1|3834|gw1.5.462.1 - 53 2.4e-06 26.8 0.1 1 1 2.6e-10 3.1e-06 26.5 0.0 6 37 4 36 1 36 0.92 UBA/TS-N domain +Kunitz_BPTI PF00014.16 53 jgi|Monbr1|3838|gw1.3.704.1 - 51 6.3e-22 77.2 6.4 1 1 5.7e-26 6.8e-22 77.1 4.4 2 52 1 51 1 51 1.00 Kunitz/Bovine pancreatic trypsin inhibitor domain +Ank PF00023.23 33 jgi|Monbr1|4686|fgenesh1_pg.scaffold_2000002 - 205 8.6e-06 25.0 0.0 1 1 2.2e-09 2.6e-05 23.4 0.0 2 33 63 94 62 94 0.97 Ankyrin repeat +MtN3_slv PF03083.9 88 jgi|Monbr1|4695|fgenesh1_pg.scaffold_2000011 - 249 9.1e-36 121.3 4.8 1 2 1.6e-17 9.3e-14 50.7 0.2 12 84 60 131 46 135 0.88 MtN3/saliva family +MtN3_slv PF03083.9 88 jgi|Monbr1|4695|fgenesh1_pg.scaffold_2000011 - 249 9.1e-36 121.3 4.8 2 2 2.5e-24 1.5e-20 72.5 0.3 2 83 164 245 163 249 0.94 MtN3/saliva family +NnrS PF05940.5 379 jgi|Monbr1|4695|fgenesh1_pg.scaffold_2000011 - 249 0.17 10.4 11.4 1 2 0.0012 7.2 5.0 0.4 108 162 55 109 21 129 0.74 NnrS protein +NnrS PF05940.5 379 jgi|Monbr1|4695|fgenesh1_pg.scaffold_2000011 - 249 0.17 10.4 11.4 2 2 4e-05 0.24 9.9 2.8 90 180 150 241 124 245 0.77 NnrS protein +DUF2486 PF10667.2 246 jgi|Monbr1|4706|fgenesh1_pg.scaffold_2000022 - 365 1.5 8.9 7.6 1 1 0.00022 2.6 8.2 5.3 45 166 174 307 166 332 0.69 Protein of unknown function (DUF2486) +SAP PF02037.20 35 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 1.9e-12 46.0 0.9 1 2 1.3e-15 1.9e-12 46.0 0.6 1 35 10 44 10 44 0.97 SAP domain +SAP PF02037.20 35 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 1.9e-12 46.0 0.9 2 2 1.7 2.5e+03 -2.2 0.0 6 17 119 130 119 130 0.73 SAP domain +DUF3275 PF11679.1 214 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 0.0047 16.2 2.8 1 1 3.9e-06 0.0059 15.9 1.9 67 164 15 113 8 157 0.67 Protein of unknown function (DUF3275) +MSP1_C PF07462.4 574 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 0.11 10.4 2.3 1 1 8.7e-05 0.13 10.3 1.6 236 321 25 120 8 146 0.66 Merozoite surface protein 1 (MSP1) C-terminus +DUF2486 PF10667.2 246 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 0.23 11.6 4.2 1 1 0.00017 0.25 11.5 2.9 65 140 55 128 5 157 0.66 Protein of unknown function (DUF2486) +DUF1631 PF07793.4 730 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 0.49 8.1 4.8 1 1 0.00043 0.65 7.7 3.3 570 642 15 112 3 129 0.70 Protein of unknown function (DUF1631) +Herpes_UL25 PF01499.9 540 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 0.5 8.2 7.4 1 1 0.00022 0.32 8.9 4.3 42 124 6 95 1 117 0.68 Herpesvirus UL25 family +Sds3 PF08598.4 205 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 0.59 9.3 5.1 1 1 0.00054 0.81 8.8 3.6 96 189 33 127 2 155 0.74 Sds3-like +TSP9 PF11493.1 80 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 1.2 9.4 7.1 1 2 0.00062 0.92 9.8 1.0 31 71 47 88 30 90 0.80 Thylakoid soluble phosphoprotein TSP9 +TSP9 PF11493.1 80 jgi|Monbr1|4720|fgenesh1_pg.scaffold_2000036 - 163 1.2 9.4 7.1 2 2 0.11 1.6e+02 2.6 0.3 1 35 91 122 88 133 0.74 Thylakoid soluble phosphoprotein TSP9 +DUF1640 PF07798.4 177 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.001 18.8 5.1 1 3 1.7 1.8e+03 -1.6 0.1 122 130 171 179 125 203 0.51 Protein of unknown function (DUF1640) +DUF1640 PF07798.4 177 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.001 18.8 5.1 2 3 0.011 12 5.6 1.5 52 155 214 318 169 328 0.73 Protein of unknown function (DUF1640) +DUF1640 PF07798.4 177 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.001 18.8 5.1 3 3 6.7e-05 0.073 12.8 0.1 50 149 346 516 308 519 0.83 Protein of unknown function (DUF1640) +Syntaxin-6_N PF09177.4 97 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0013 18.7 3.3 1 5 0.44 4.8e+02 0.9 0.2 33 53 128 148 69 176 0.67 Syntaxin 6, N-terminal +Syntaxin-6_N PF09177.4 97 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0013 18.7 3.3 2 5 1.5 1.6e+03 -0.8 0.0 10 32 185 207 178 226 0.71 Syntaxin 6, N-terminal +Syntaxin-6_N PF09177.4 97 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0013 18.7 3.3 3 5 1.2e-06 0.0013 18.7 2.3 26 83 246 310 236 321 0.79 Syntaxin 6, N-terminal +Syntaxin-6_N PF09177.4 97 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0013 18.7 3.3 4 5 0.00091 0.98 9.5 3.7 8 93 326 405 320 427 0.87 Syntaxin 6, N-terminal +Syntaxin-6_N PF09177.4 97 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0013 18.7 3.3 5 5 0.26 2.8e+02 1.7 0.1 10 51 474 517 466 523 0.51 Syntaxin 6, N-terminal +IncA PF04156.7 191 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0018 17.5 24.2 1 4 0.079 86 2.3 3.1 120 185 127 203 121 207 0.76 IncA protein +IncA PF04156.7 191 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0018 17.5 24.2 2 4 1.7e-06 0.0018 17.5 16.8 55 183 252 386 249 394 0.84 IncA protein +IncA PF04156.7 191 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0018 17.5 24.2 3 4 1.1 1.2e+03 -1.5 0.2 157 184 395 422 383 429 0.40 IncA protein +IncA PF04156.7 191 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.0018 17.5 24.2 4 4 1.2 1.3e+03 -1.6 0.0 87 102 497 512 463 519 0.56 IncA protein +Vhr1 PF04001.6 96 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.087 12.4 0.5 1 2 0.22 2.4e+02 1.3 0.0 13 42 7 36 5 59 0.82 Transcription factor Vhr1 +Vhr1 PF04001.6 96 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.087 12.4 0.5 2 2 0.0022 2.4 7.8 0.4 48 93 259 304 247 307 0.90 Transcription factor Vhr1 +DUF2089 PF09862.2 113 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.11 12.0 0.6 1 2 0.00076 0.82 9.1 0.0 41 88 253 300 240 329 0.77 Protein of unknown function(DUF2089) +DUF2089 PF09862.2 113 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.11 12.0 0.6 2 2 0.52 5.7e+02 -0.0 0.1 65 86 358 379 319 395 0.70 Protein of unknown function(DUF2089) +zf-C3HC PF07967.6 134 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.18 11.2 5.0 1 2 0.00054 0.58 9.6 0.4 62 104 271 313 244 336 0.71 C3HC zinc finger-like +zf-C3HC PF07967.6 134 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.18 11.2 5.0 2 2 0.067 72 2.8 0.8 65 126 331 394 315 402 0.79 C3HC zinc finger-like +LIF_OSM PF01291.10 197 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.68 9.1 3.2 1 3 0.00049 0.53 9.5 0.1 89 169 133 214 117 226 0.78 LIF / OSM family +LIF_OSM PF01291.10 197 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.68 9.1 3.2 2 3 3.4 3.7e+03 -3.0 0.0 111 143 259 291 251 305 0.72 LIF / OSM family +LIF_OSM PF01291.10 197 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.68 9.1 3.2 3 3 1.6 1.8e+03 -2.0 0.1 130 130 335 335 289 392 0.58 LIF / OSM family +Polysacc_deac_2 PF04748.6 213 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.81 8.3 5.1 1 3 1.3 1.5e+03 -2.3 0.0 96 117 180 201 169 203 0.84 Divergent polysaccharide deacetylase +Polysacc_deac_2 PF04748.6 213 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.81 8.3 5.1 2 3 0.58 6.3e+02 -1.2 0.1 162 186 283 297 250 325 0.55 Divergent polysaccharide deacetylase +Polysacc_deac_2 PF04748.6 213 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.81 8.3 5.1 3 3 0.00053 0.57 8.8 0.9 77 119 332 374 283 377 0.79 Divergent polysaccharide deacetylase +Cenp-F_N PF10481.2 288 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.84 8.4 3.9 1 1 0.0022 2.4 6.9 2.7 104 187 275 358 250 409 0.83 Cenp-F N-terminal domain +Sipho_Gp157 PF05565.4 162 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.95 8.7 12.5 1 3 0.66 7.2e+02 -0.7 0.1 54 107 166 219 130 223 0.75 Siphovirus Gp157 +Sipho_Gp157 PF05565.4 162 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.95 8.7 12.5 2 3 0.0038 4.1 6.6 0.5 35 84 268 317 247 341 0.82 Siphovirus Gp157 +Sipho_Gp157 PF05565.4 162 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 0.95 8.7 12.5 3 3 0.0012 1.3 8.2 1.2 2 73 355 426 354 432 0.91 Siphovirus Gp157 +TBPIP PF07106.6 169 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 1.1 8.4 20.3 1 4 0.025 28 3.9 0.1 110 157 131 178 122 183 0.88 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) +TBPIP PF07106.6 169 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 1.1 8.4 20.3 2 4 0.012 13 4.9 5.7 78 144 279 351 258 372 0.74 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) +TBPIP PF07106.6 169 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 1.1 8.4 20.3 3 4 0.12 1.3e+02 1.6 1.9 72 102 368 398 345 424 0.42 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) +TBPIP PF07106.6 169 jgi|Monbr1|4724|fgenesh1_pg.scaffold_2000040 - 528 1.1 8.4 20.3 4 4 0.084 91 2.2 0.0 66 91 492 517 456 523 0.73 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) +DUF2215 PF10225.2 261 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 1e-21 77.2 0.2 1 1 1.2e-24 2e-21 76.2 0.1 4 180 132 308 129 406 0.71 Uncharacterized conserved protein (DUF2215) +DUF63 PF01889.10 273 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 0.03 14.0 2.2 1 1 3e-05 0.052 13.3 1.5 92 169 142 220 129 257 0.83 Membrane protein of unknown function DUF63 +DUF2339 PF10101.2 745 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 0.076 10.9 9.1 1 1 6.9e-05 0.12 10.3 6.3 223 374 138 283 92 320 0.68 Predicted membrane protein (DUF2339) +DUF981 PF06168.4 191 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 0.3 10.5 9.6 1 1 0.00035 0.6 9.5 6.6 50 173 142 286 123 303 0.75 Protein of unknown function (DUF981) +DUF2910 PF11139.1 214 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 0.69 8.6 14.0 1 3 2.7 4.6e+03 -3.9 0.2 46 52 10 16 5 32 0.49 Protein of unknown function (DUF2910) +DUF2910 PF11139.1 214 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 0.69 8.6 14.0 2 3 7.8e-06 0.013 14.2 4.0 17 53 148 184 144 237 0.76 Protein of unknown function (DUF2910) +DUF2910 PF11139.1 214 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 0.69 8.6 14.0 3 3 0.63 1.1e+03 -1.8 0.0 39 65 291 316 289 324 0.66 Protein of unknown function (DUF2910) +DUF395 PF04143.7 43 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 1.2 8.9 3.3 1 1 0.0019 3.2 7.5 2.3 5 20 195 210 193 210 0.92 YeeE/YedE family (DUF395) +7TM-7TMR_HD PF07698.4 194 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 1.4 7.9 12.5 1 3 0.0014 2.4 7.2 3.5 107 174 141 208 134 217 0.76 7TM receptor with intracellular HD hydrolase +7TM-7TMR_HD PF07698.4 194 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 1.4 7.9 12.5 2 3 0.011 18 4.3 0.3 47 101 249 308 228 315 0.75 7TM receptor with intracellular HD hydrolase +7TM-7TMR_HD PF07698.4 194 jgi|Monbr1|4730|fgenesh1_pg.scaffold_2000046 - 595 1.4 7.9 12.5 3 3 1.1 1.9e+03 -2.2 0.0 122 145 529 552 527 559 0.82 7TM receptor with intracellular HD hydrolase +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 1 7 0.041 1.2e+02 2.0 6.3 79 139 141 201 110 213 0.54 Autophagy protein 16 (ATG16) +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 2 7 0.17 5e+02 0.0 7.0 86 139 148 201 137 233 0.48 Autophagy protein 16 (ATG16) +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 3 7 0.0024 7 6.1 3.2 13 106 282 375 270 394 0.76 Autophagy protein 16 (ATG16) +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 4 7 0.078 2.3e+02 1.1 10.4 38 137 574 677 527 686 0.69 Autophagy protein 16 (ATG16) +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 5 7 0.23 6.9e+02 -0.4 6.0 52 138 685 775 661 782 0.72 Autophagy protein 16 (ATG16) +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 6 7 5e-08 0.00015 21.3 12.8 20 146 785 917 779 921 0.87 Autophagy protein 16 (ATG16) +ATG16 PF08614.4 194 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.00015 21.3 18.4 7 7 0.002 6.1 6.3 12.9 23 131 936 1037 919 1050 0.70 Autophagy protein 16 (ATG16) +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 1 12 0.69 2e+03 -1.7 0.1 17 44 24 51 11 54 0.79 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 2 12 0.0012 3.7 7.1 3.3 17 68 141 192 139 194 0.90 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 3 12 0.78 2.3e+03 -1.9 0.3 14 24 292 302 278 310 0.50 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 4 12 0.022 64 3.1 0.1 17 43 348 374 343 391 0.62 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 5 12 0.014 42 3.7 3.9 12 72 574 639 568 641 0.78 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 6 12 0.042 1.2e+02 2.2 3.8 25 73 613 661 598 662 0.71 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 7 12 0.0058 17 4.9 0.1 39 72 701 734 669 736 0.82 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 8 12 0.012 35 3.9 1.2 24 73 776 825 769 826 0.68 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 9 12 1.7e-06 0.005 16.3 1.0 13 72 853 912 849 914 0.96 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 10 12 0.4 1.2e+03 -1.0 0.6 37 51 948 962 922 971 0.50 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 11 12 1.2 3.6e+03 -2.5 5.0 16 58 948 990 934 996 0.53 TATA element modulatory factor 1 DNA binding +TMF_DNA_bd PF12329.1 74 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.005 16.3 1.4 12 12 0.079 2.3e+02 1.3 2.7 25 68 975 1029 968 1034 0.57 TATA element modulatory factor 1 DNA binding +DUF2652 PF10851.1 116 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.044 13.4 0.1 1 1 6.9e-05 0.2 11.3 0.1 5 71 634 701 631 708 0.85 Protein of unknown function (DUF2652) +TrbI_Ftype PF09677.3 111 jgi|Monbr1|4737|fgenesh1_pg.scaffold_2000053 - 1061 0.17 11.3 5.2 1 1 0.0004 1.2 8.6 3.6 44 86 962 1004 955 1006 0.92 Type-F conjugative transfer system protein (TrbI_Ftype) +2OG-FeII_Oxy PF03171.13 97 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 7.4e-05 22.7 0.5 1 1 1e-07 0.00031 20.7 0.3 4 95 243 366 240 368 0.87 2OG-Fe(II) oxygenase superfamily +TPR_2 PF07719.10 34 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.0026 17.2 0.0 1 3 0.00021 0.63 9.7 0.0 9 33 39 63 39 64 0.88 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.0026 17.2 0.0 2 3 0.62 1.9e+03 -1.1 0.0 24 34 91 101 84 101 0.79 Tetratricopeptide repeat +TPR_2 PF07719.10 34 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.0026 17.2 0.0 3 3 0.022 66 3.4 0.0 4 27 105 128 102 128 0.87 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.016 14.4 0.1 1 3 0.00093 2.8 7.4 0.0 9 29 39 59 39 64 0.78 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.016 14.4 0.1 2 3 0.62 1.9e+03 -1.6 0.0 25 34 92 101 92 101 0.86 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.016 14.4 0.1 3 3 0.013 39 3.7 0.0 8 27 109 128 102 128 0.89 Tetratricopeptide repeat +TauD PF02668.9 255 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.19 11.0 2.5 1 2 0.74 2.2e+03 -2.3 0.2 233 252 86 106 83 108 0.74 Taurine catabolism dioxygenase TauD, TfdA family +TauD PF02668.9 255 jgi|Monbr1|4738|fgenesh1_pg.scaffold_2000054 - 371 0.19 11.0 2.5 2 2 3e-05 0.089 12.1 0.1 91 186 251 337 189 361 0.77 Taurine catabolism dioxygenase TauD, TfdA family +ELO PF01151.11 250 jgi|Monbr1|4746|fgenesh1_pg.scaffold_2000062 - 1057 2.7e-58 196.9 10.4 1 1 7.8e-62 4.7e-58 196.1 7.2 6 247 821 1049 817 1052 0.89 GNS1/SUR4 family +Nucleotid_trans PF03407.9 212 jgi|Monbr1|4746|fgenesh1_pg.scaffold_2000062 - 1057 1e-14 54.5 0.0 1 2 9.4e-10 5.6e-06 25.9 0.0 4 70 572 639 569 641 0.85 Nucleotide-diphospho-sugar transferase +Nucleotid_trans PF03407.9 212 jgi|Monbr1|4746|fgenesh1_pg.scaffold_2000062 - 1057 1e-14 54.5 0.0 2 2 5.5e-10 3.3e-06 26.7 0.0 114 212 641 757 639 757 0.91 Nucleotide-diphospho-sugar transferase +DUF2365 PF10157.2 149 jgi|Monbr1|4750|fgenesh1_pg.scaffold_2000066 - 155 0.0013 18.3 0.0 1 1 2.7e-07 0.0016 18.0 0.0 48 99 42 93 13 115 0.88 Uncharacterized conserved protein (DUF2365) +Phage_lysis PF03245.6 153 jgi|Monbr1|4750|fgenesh1_pg.scaffold_2000066 - 155 0.43 10.1 2.3 1 1 0.00012 0.73 9.3 1.6 17 93 77 153 62 154 0.81 Bacteriophage lysis protein +DUF294_C PF10335.2 145 jgi|Monbr1|4755|fgenesh1_pg.scaffold_2000071 - 685 1.3 8.3 4.1 1 1 0.00025 3 7.1 2.9 98 133 287 322 285 333 0.86 Putative nucleotidyltransferase substrate binding domain +SAP PF02037.20 35 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.017 14.3 1.6 1 4 0.6 2.4e+03 -2.2 0.1 10 17 95 102 95 103 0.86 SAP domain +SAP PF02037.20 35 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.017 14.3 1.6 2 4 0.9 3.6e+03 -2.7 0.0 27 34 143 150 142 151 0.84 SAP domain +SAP PF02037.20 35 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.017 14.3 1.6 3 4 0.42 1.7e+03 -1.6 0.0 24 34 225 235 220 236 0.82 SAP domain +SAP PF02037.20 35 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.017 14.3 1.6 4 4 2.3e-05 0.093 11.9 0.0 5 27 389 411 385 413 0.91 SAP domain +Amidohydro_3 PF07969.4 404 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.059 12.2 0.1 1 1 2.9e-05 0.12 11.3 0.1 234 317 180 263 145 279 0.83 Amidohydrolase family +Flu_M1 PF00598.12 157 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.14 11.2 0.4 1 2 0.00012 0.49 9.4 0.0 94 152 55 113 25 118 0.92 Influenza Matrix protein (M1) +Flu_M1 PF00598.12 157 jgi|Monbr1|4757|fgenesh1_pg.scaffold_2000073 - 448 0.14 11.2 0.4 2 2 0.26 1e+03 -1.4 0.1 67 90 327 350 323 383 0.67 Influenza Matrix protein (M1) +Laminin_G_2 PF02210.17 128 jgi|Monbr1|4761|fgenesh1_pg.scaffold_2000077 - 634 0.036 13.7 0.1 1 2 8.6e-06 0.1 12.3 0.0 32 82 302 355 272 378 0.64 Laminin G domain +Laminin_G_2 PF02210.17 128 jgi|Monbr1|4761|fgenesh1_pg.scaffold_2000077 - 634 0.036 13.7 0.1 2 2 0.5 5.9e+03 -3.1 0.0 4 34 450 480 449 494 0.73 Laminin G domain +Spore_YhcN_YlaJ PF09580.3 174 jgi|Monbr1|4763|fgenesh1_pg.scaffold_2000079 - 165 0.12 12.1 1.2 1 1 1.1e-05 0.13 12.0 0.8 19 63 102 142 40 154 0.59 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) +Syndecan PF01034.13 328 jgi|Monbr1|4764|fgenesh1_pg.scaffold_2000080 - 293 0.016 14.8 9.7 1 1 1.1e-05 0.023 14.3 6.7 98 214 124 241 80 250 0.69 Syndecan domain +Osteopontin PF00865.11 312 jgi|Monbr1|4764|fgenesh1_pg.scaffold_2000080 - 293 0.074 11.9 0.9 1 1 5.2e-05 0.1 11.4 0.7 56 95 169 208 122 214 0.71 Osteopontin +Herpes_BLLF1 PF05109.6 830 jgi|Monbr1|4764|fgenesh1_pg.scaffold_2000080 - 293 0.35 8.4 10.6 1 1 0.00018 0.36 8.4 7.3 447 571 112 188 21 245 0.60 Herpes virus major outer envelope glycoprotein (BLLF1) +But2 PF09792.2 446 jgi|Monbr1|4764|fgenesh1_pg.scaffold_2000080 - 293 0.39 9.4 5.2 1 1 0.00025 0.49 9.1 3.6 172 234 122 189 91 280 0.65 Ubiquitin 3 binding protein But2 +MSP1_C PF07462.4 574 jgi|Monbr1|4764|fgenesh1_pg.scaffold_2000080 - 293 0.89 7.5 6.4 1 1 0.00059 1.2 7.1 4.4 256 350 112 208 95 215 0.49 Merozoite surface protein 1 (MSP1) C-terminus +Med3 PF11593.1 379 jgi|Monbr1|4764|fgenesh1_pg.scaffold_2000080 - 293 1.2 7.9 8.6 1 1 0.00092 1.8 7.3 6.0 126 200 116 194 95 277 0.59 Mediator complex subunit 3 fungal +Ricin_B_lectin PF00652.15 125 jgi|Monbr1|4769|fgenesh1_pg.scaffold_2000085 - 659 0.0021 17.7 0.1 1 1 6.2e-07 0.0037 16.9 0.0 24 117 159 248 152 255 0.75 Ricin-type beta-trefoil lectin domain +ProSAAS PF07259.5 188 jgi|Monbr1|4769|fgenesh1_pg.scaffold_2000085 - 659 0.3 10.2 3.1 1 1 0.0001 0.61 9.2 2.1 102 145 48 94 34 107 0.71 ProSAAS precursor +Cons_hypoth698 PF03601.7 305 jgi|Monbr1|4770|fgenesh1_pg.scaffold_2000086 - 367 2e-42 144.6 8.0 1 1 5.9e-46 3.5e-42 143.8 5.6 5 303 1 342 1 344 0.87 Conserved hypothetical protein 698 +SirB PF04247.5 123 jgi|Monbr1|4770|fgenesh1_pg.scaffold_2000086 - 367 0.012 15.0 0.1 1 2 2.1e-05 0.13 11.7 0.0 69 108 81 120 74 130 0.76 Invasion gene expression up-regulator, SirB +SirB PF04247.5 123 jgi|Monbr1|4770|fgenesh1_pg.scaffold_2000086 - 367 0.012 15.0 0.1 2 2 0.12 7.2e+02 -0.5 0.0 36 59 268 291 263 302 0.70 Invasion gene expression up-regulator, SirB +TTL PF03133.8 294 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 1.9e-53 181.0 0.0 1 1 9.6e-57 2.9e-53 180.4 0.0 15 278 1154 1388 1148 1389 0.93 Tubulin-tyrosine ligase family +Kelch_1 PF01344.18 47 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 2.5e-27 93.8 0.0 1 5 8.4e-07 0.0025 17.0 0.0 1 45 758 799 758 800 0.89 Kelch motif +Kelch_1 PF01344.18 47 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 2.5e-27 93.8 0.0 2 5 1.2e-11 3.7e-08 32.4 0.0 4 47 806 849 804 849 0.96 Kelch motif +Kelch_1 PF01344.18 47 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 2.5e-27 93.8 0.0 3 5 1e-08 3e-05 23.1 0.0 9 46 860 897 853 898 0.92 Kelch motif +Kelch_1 PF01344.18 47 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 2.5e-27 93.8 0.0 4 5 0.0001 0.3 10.3 0.0 1 31 900 930 900 955 0.83 Kelch motif +Kelch_1 PF01344.18 47 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 2.5e-27 93.8 0.0 5 5 0.019 57 3.0 0.0 1 36 958 995 958 996 0.93 Kelch motif +Kelch_2 PF07646.8 49 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 1.9e-11 43.2 0.2 1 5 0.00019 0.57 10.0 0.0 2 19 759 776 758 786 0.85 Kelch motif +Kelch_2 PF07646.8 49 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 1.9e-11 43.2 0.2 2 5 0.00045 1.3 8.8 0.0 3 43 805 843 803 849 0.77 Kelch motif +Kelch_2 PF07646.8 49 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 1.9e-11 43.2 0.2 3 5 0.00021 0.61 9.9 0.0 7 48 858 897 852 898 0.87 Kelch motif +Kelch_2 PF07646.8 49 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 1.9e-11 43.2 0.2 4 5 0.0011 3.1 7.7 0.0 1 45 900 952 900 956 0.69 Kelch motif +Kelch_2 PF07646.8 49 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 1.9e-11 43.2 0.2 5 5 0.88 2.6e+03 -1.6 0.0 2 22 959 979 958 995 0.74 Kelch motif +DUF1668 PF07893.6 339 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 0.002 17.0 0.1 1 3 0.31 9.3e+02 -1.6 0.0 157 173 583 599 559 606 0.70 Protein of unknown function (DUF1668) +DUF1668 PF07893.6 339 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 0.002 17.0 0.1 2 3 0.053 1.6e+02 0.9 0.0 88 129 739 780 721 806 0.81 Protein of unknown function (DUF1668) +DUF1668 PF07893.6 339 jgi|Monbr1|4775|fgenesh1_pg.scaffold_2000091 - 1389 0.002 17.0 0.1 3 3 1.9e-05 0.055 12.2 0.0 66 132 851 925 823 963 0.74 Protein of unknown function (DUF1668) +DAO PF01266.17 358 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 3.3e-25 88.4 8.5 1 1 2.2e-28 5.1e-25 87.8 5.9 1 356 10 388 10 390 0.73 FAD dependent oxidoreductase +Lycopene_cycl PF05834.5 374 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 5.4e-08 31.8 0.3 1 2 3.1e-07 0.00074 18.2 0.1 1 47 10 60 10 98 0.87 Lycopene cyclase protein +Lycopene_cycl PF05834.5 374 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 5.4e-08 31.8 0.3 2 2 2.7e-05 0.064 11.8 0.0 92 151 181 241 160 256 0.82 Lycopene cyclase protein +Pyr_redox_2 PF07992.7 202 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 0.0014 17.8 0.1 1 1 2.3e-05 0.054 12.7 0.0 1 107 10 230 10 264 0.59 Pyridine nucleotide-disulphide oxidoreductase +FAD_binding_2 PF00890.17 421 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 0.031 12.8 1.1 1 1 4.6e-05 0.11 11.0 0.8 1 43 10 53 10 233 0.92 FAD binding domain +GIDA PF01134.15 392 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 0.12 10.9 0.2 1 2 0.0082 19 3.6 0.1 1 17 10 26 10 54 0.87 Glucose inhibited division protein A +GIDA PF01134.15 392 jgi|Monbr1|4779|fgenesh1_pg.scaffold_2000095 - 414 0.12 10.9 0.2 2 2 0.0026 6.1 5.2 0.0 130 155 210 235 183 247 0.81 Glucose inhibited division protein A +AAA PF00004.22 130 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 9.5e-87 287.5 0.0 1 2 2.6e-40 9e-38 129.1 0.0 1 128 30 169 30 171 0.96 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 9.5e-87 287.5 0.0 2 2 9e-49 3.2e-46 156.4 0.0 1 129 274 406 274 407 0.97 ATPase family associated with various cellular activities (AAA) +AAA_5 PF07728.7 139 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4e-15 55.4 0.3 1 2 7.6e-11 2.7e-08 33.3 0.0 1 137 29 159 29 161 0.73 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4e-15 55.4 0.3 2 2 4.6e-06 0.0016 17.8 0.0 1 76 273 341 273 395 0.68 AAA domain (dynein-related subfamily) +AAA_2 PF07724.7 171 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 5e-14 52.2 0.0 1 2 3.6e-10 1.3e-07 31.4 0.0 6 105 30 128 25 138 0.81 AAA domain (Cdc48 subfamily) +AAA_2 PF07724.7 171 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 5e-14 52.2 0.0 2 2 3.3e-06 0.0012 18.5 0.0 6 98 274 357 271 371 0.72 AAA domain (Cdc48 subfamily) +RuvB_N PF05496.5 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 5.6e-14 51.4 0.2 1 3 5e-10 1.8e-07 30.1 0.1 52 168 29 159 24 175 0.75 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 5.6e-14 51.4 0.2 2 3 2.8e-06 0.00097 17.9 0.0 52 86 273 307 262 344 0.88 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 5.6e-14 51.4 0.2 3 3 5.1 1.8e+03 -2.6 0.0 228 228 369 369 349 405 0.54 Holliday junction DNA helicase ruvB N-terminus +Zeta_toxin PF06414.5 201 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.3e-09 35.8 0.0 1 2 5.7e-05 0.02 13.7 0.0 16 49 27 59 16 63 0.85 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.3e-09 35.8 0.0 2 2 9.8e-07 0.00034 19.4 0.0 14 139 269 416 260 427 0.72 Zeta toxin +Mg_chelatase PF01078.14 207 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 2.8e-08 32.8 3.0 1 3 3.7e-06 0.0013 17.6 0.1 23 46 28 51 23 89 0.82 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 2.8e-08 32.8 3.0 2 3 3.1 1.1e+03 -1.7 0.0 106 120 90 105 79 118 0.73 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 2.8e-08 32.8 3.0 3 3 3e-05 0.011 14.6 0.1 25 43 274 292 264 298 0.91 Magnesium chelatase, subunit ChlI +IstB PF01695.10 178 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4.6e-08 32.3 0.9 1 2 6.3e-05 0.022 13.8 0.1 48 69 28 49 19 56 0.91 IstB-like ATP binding protein +IstB PF01695.10 178 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4.6e-08 32.3 0.9 2 2 1.3e-05 0.0045 16.1 0.0 49 71 273 295 268 314 0.85 IstB-like ATP binding protein +RNA_helicase PF00910.15 107 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.1e-07 31.6 0.0 1 2 0.00011 0.039 13.8 0.0 1 25 30 54 30 77 0.83 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.1e-07 31.6 0.0 2 2 4e-05 0.014 15.2 0.0 1 26 274 299 274 339 0.79 RNA helicase +NACHT PF05729.5 166 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.3e-07 31.1 1.9 1 4 3.5e-05 0.012 14.9 0.0 3 26 30 53 28 60 0.89 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.3e-07 31.1 1.9 2 4 1.6 5.6e+02 -0.3 0.0 73 113 83 123 67 130 0.61 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.3e-07 31.1 1.9 3 4 0.00029 0.1 11.9 0.1 3 26 274 297 273 370 0.93 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.3e-07 31.1 1.9 4 4 2.7 9.3e+02 -1.0 0.0 135 159 354 378 346 379 0.74 NACHT domain +TIP49 PF06068.6 398 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 2.5e-07 29.4 0.0 1 2 6.1e-06 0.0021 16.5 0.0 52 112 29 88 26 129 0.80 TIP49 C-terminus +TIP49 PF06068.6 398 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 2.5e-07 29.4 0.0 2 2 0.00037 0.13 10.6 0.0 52 105 273 325 263 328 0.82 TIP49 C-terminus +KaiC PF06745.6 226 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.8e-06 25.8 0.1 1 3 0.0017 0.6 8.8 0.0 13 37 21 45 15 50 0.85 KaiC +KaiC PF06745.6 226 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.8e-06 25.8 0.1 2 3 0.016 5.5 5.7 0.0 92 149 67 129 55 133 0.78 KaiC +KaiC PF06745.6 226 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.8e-06 25.8 0.1 3 3 0.0043 1.5 7.5 0.0 21 38 273 290 261 303 0.80 KaiC +Viral_helicase1 PF01443.11 226 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4.9e-06 25.9 0.0 1 2 1.9e-05 0.0066 15.7 0.0 2 67 31 100 30 104 0.72 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4.9e-06 25.9 0.0 2 2 0.0042 1.5 8.0 0.0 4 66 277 338 274 344 0.57 Viral (Superfamily 1) RNA helicase +Sigma54_activat PF00158.19 168 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.7e-05 24.0 0.0 1 3 0.0028 0.98 8.5 0.0 23 43 28 48 19 60 0.88 Sigma-54 interaction domain +Sigma54_activat PF00158.19 168 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.7e-05 24.0 0.0 2 3 0.14 50 2.9 0.0 90 108 88 106 79 148 0.84 Sigma-54 interaction domain +Sigma54_activat PF00158.19 168 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 1.7e-05 24.0 0.0 3 3 0.004 1.4 8.0 0.0 21 45 270 294 259 313 0.83 Sigma-54 interaction domain +AAA_3 PF07726.4 131 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.8e-05 22.9 0.1 1 2 0.0014 0.49 9.7 0.0 2 29 30 57 29 124 0.74 ATPase family associated with various cellular activities (AAA) +AAA_3 PF07726.4 131 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 3.8e-05 22.9 0.1 2 2 0.0012 0.41 9.9 0.0 2 31 274 303 273 337 0.89 ATPase family associated with various cellular activities (AAA) +UPF0079 PF02367.10 123 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4.4e-05 22.8 0.0 1 2 0.00074 0.26 10.6 0.0 18 48 30 61 17 64 0.85 Uncharacterised P-loop hydrolase UPF0079 +UPF0079 PF02367.10 123 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 4.4e-05 22.8 0.0 2 2 0.0014 0.49 9.7 0.0 18 42 274 298 261 312 0.81 Uncharacterised P-loop hydrolase UPF0079 +Arch_ATPase PF01637.11 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0001 21.8 0.0 1 4 0.011 4 6.7 0.0 23 44 30 51 18 59 0.86 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0001 21.8 0.0 2 4 3.3 1.2e+03 -1.4 0.0 101 131 70 104 53 129 0.65 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0001 21.8 0.0 3 4 0.0042 1.5 8.1 0.0 22 42 273 293 261 299 0.82 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0001 21.8 0.0 4 4 0.21 74 2.6 0.0 86 165 299 384 288 410 0.70 Archaeal ATPase +PhoH PF02562.9 205 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00014 20.8 0.1 1 3 0.0021 0.74 8.7 0.0 22 41 30 49 19 54 0.88 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00014 20.8 0.1 2 3 0.002 0.69 8.8 0.1 22 40 274 292 266 300 0.88 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00014 20.8 0.1 3 3 7.1 2.5e+03 -2.9 0.0 112 128 323 339 317 345 0.84 PhoH-like protein +Parvo_NS1 PF01057.10 272 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00036 19.1 0.0 1 2 0.0037 1.3 7.5 0.0 117 135 30 48 24 53 0.90 Parvovirus non-structural protein NS1 +Parvo_NS1 PF01057.10 272 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00036 19.1 0.0 2 2 0.0011 0.38 9.2 0.0 117 138 274 295 267 298 0.93 Parvovirus non-structural protein NS1 +NB-ARC PF00931.15 285 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00057 18.5 0.0 1 2 0.001 0.36 9.3 0.0 22 41 30 49 19 54 0.87 NB-ARC domain +NB-ARC PF00931.15 285 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00057 18.5 0.0 2 2 0.0074 2.6 6.5 0.0 22 41 274 293 262 299 0.87 NB-ARC domain +DUF815 PF05673.6 250 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00059 18.5 0.0 1 2 0.0034 1.2 7.6 0.0 51 85 25 59 16 117 0.72 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.00059 18.5 0.0 2 2 0.0022 0.77 8.3 0.0 56 116 274 339 264 396 0.70 Protein of unknown function (DUF815) +Vps4_C PF09336.3 62 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0016 17.9 0.0 1 1 1.2e-05 0.0041 16.6 0.0 26 55 477 506 472 509 0.92 Vps4 C terminal oligomerisation domain +SKI PF01202.15 158 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0018 17.8 0.0 1 2 0.015 5.4 6.5 0.0 1 20 36 55 36 61 0.92 Shikimate kinase +SKI PF01202.15 158 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0018 17.8 0.0 2 2 0.0035 1.2 8.6 0.0 1 23 280 302 280 328 0.77 Shikimate kinase +Rad17 PF03215.8 498 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0044 15.5 0.0 1 2 0.013 4.5 5.6 0.0 48 79 30 61 24 86 0.81 Rad17 cell cycle checkpoint protein +Rad17 PF03215.8 498 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0044 15.5 0.0 2 2 0.0032 1.1 7.6 0.0 48 84 274 310 265 340 0.82 Rad17 cell cycle checkpoint protein +PduV-EutP PF10662.2 143 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.005 16.0 0.0 1 2 0.021 7.4 5.7 0.0 4 24 30 50 28 53 0.90 Ethanolamine utilisation - propanediol utilisation +PduV-EutP PF10662.2 143 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.005 16.0 0.0 2 2 0.0065 2.3 7.4 0.0 4 23 274 293 272 299 0.91 Ethanolamine utilisation - propanediol utilisation +CPT PF07931.5 174 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0052 16.1 0.1 1 3 0.008 2.8 7.2 0.0 4 33 30 59 28 65 0.91 Chloramphenicol phosphotransferase-like protein +CPT PF07931.5 174 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0052 16.1 0.1 2 3 1.7 5.9e+02 -0.4 0.0 74 109 83 122 60 177 0.70 Chloramphenicol phosphotransferase-like protein +CPT PF07931.5 174 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0052 16.1 0.1 3 3 0.076 27 4.0 0.0 4 33 274 303 273 324 0.87 Chloramphenicol phosphotransferase-like protein +ATP-synt_ab PF00006.18 215 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0066 15.6 0.0 1 2 0.15 54 2.8 0.0 19 39 31 51 28 114 0.76 ATP synthase alpha/beta family, nucleotide-binding domain +ATP-synt_ab PF00006.18 215 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0066 15.6 0.0 2 2 0.00084 0.29 10.2 0.0 19 64 275 327 273 356 0.83 ATP synthase alpha/beta family, nucleotide-binding domain +DUF265 PF03266.8 168 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0068 15.8 0.0 1 2 0.021 7.2 5.9 0.0 2 25 30 53 29 67 0.84 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.0068 15.8 0.0 2 2 0.0087 3.1 7.1 0.0 2 32 274 304 273 326 0.90 Protein of unknown function, DUF265 +KTI12 PF08433.3 270 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.011 14.5 0.1 1 2 0.014 4.9 5.9 0.0 4 30 30 56 29 124 0.74 Chromatin associated protein KTI12 +KTI12 PF08433.3 270 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.011 14.5 0.1 2 2 0.011 3.8 6.3 0.0 4 24 274 294 272 311 0.88 Chromatin associated protein KTI12 +SRPRB PF09439.3 181 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.03 13.2 0.0 1 2 0.12 43 2.9 0.0 6 23 30 47 27 74 0.82 Signal recognition particle receptor beta subunit +SRPRB PF09439.3 181 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.03 13.2 0.0 2 2 0.0042 1.5 7.7 0.0 4 29 272 297 269 320 0.78 Signal recognition particle receptor beta subunit +Zot PF05707.5 193 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.038 13.1 0.1 1 2 0.0066 2.3 7.3 0.0 70 106 81 118 30 126 0.75 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.038 13.1 0.1 2 2 2 7.1e+02 -0.8 0.0 4 17 275 288 274 298 0.87 Zonular occludens toxin (Zot) +DUF2075 PF09848.2 352 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.039 12.6 0.1 1 2 0.0065 2.3 6.8 0.0 4 25 30 51 27 88 0.83 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.039 12.6 0.1 2 2 0.064 22 3.5 0.0 7 25 277 295 273 331 0.76 Uncharacterized conserved protein (DUF2075) +DAP3 PF10236.2 309 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.05 12.2 0.0 1 2 0.021 7.4 5.1 0.0 25 45 29 48 17 81 0.83 Mitochondrial ribosomal death-associated protein 3 +DAP3 PF10236.2 309 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.05 12.2 0.0 2 2 0.024 8.3 4.9 0.0 26 60 274 307 261 321 0.83 Mitochondrial ribosomal death-associated protein 3 +Bac_DnaA PF00308.11 219 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.063 12.5 0.0 1 2 0.063 22 4.2 0.0 37 59 30 52 23 123 0.74 Bacterial dnaA protein +Bac_DnaA PF00308.11 219 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.063 12.5 0.0 2 2 0.026 9 5.5 0.0 37 63 274 300 262 327 0.86 Bacterial dnaA protein +cobW PF02492.12 173 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.09 11.9 0.1 1 2 0.031 11 5.1 0.0 4 36 31 62 29 124 0.79 CobW/HypB/UreG, nucleotide-binding domain +cobW PF02492.12 173 jgi|Monbr1|4780|fgenesh1_pg.scaffold_2000096 - 550 0.09 11.9 0.1 2 2 0.053 18 4.3 0.0 3 22 274 293 272 302 0.80 CobW/HypB/UreG, nucleotide-binding domain +LSM PF01423.15 68 jgi|Monbr1|4811|fgenesh1_pg.scaffold_2000127 - 115 1.2e-16 59.5 0.1 1 2 6.1e-20 2.4e-16 58.6 0.0 3 66 7 69 5 71 0.94 LSM domain +LSM PF01423.15 68 jgi|Monbr1|4811|fgenesh1_pg.scaffold_2000127 - 115 1.2e-16 59.5 0.1 2 2 0.55 2.2e+03 -2.1 0.0 36 48 76 88 75 98 0.64 LSM domain +API5 PF05918.4 556 jgi|Monbr1|4811|fgenesh1_pg.scaffold_2000127 - 115 0.06 11.5 6.5 1 1 1.8e-05 0.072 11.2 4.5 514 550 78 111 57 114 0.61 Apoptosis inhibitory protein 5 (API5) +FXR1P_C PF12235.1 155 jgi|Monbr1|4811|fgenesh1_pg.scaffold_2000127 - 115 0.45 10.2 11.7 1 1 0.00017 0.68 9.7 8.1 95 125 81 111 72 115 0.65 Fragile X-related 1 protein C terminal +DnaJ PF00226.24 64 jgi|Monbr1|4812|fgenesh1_pg.scaffold_2000128 - 384 5.2e-13 48.2 0.0 1 1 9e-17 1.1e-12 47.1 0.0 1 63 121 181 121 182 0.96 DnaJ domain +Cyt-b5 PF00173.21 76 jgi|Monbr1|4813|fgenesh1_pg.scaffold_2000129 - 283 1.6e-09 37.1 0.0 1 1 7.3e-13 2.9e-09 36.2 0.0 2 54 88 163 87 211 0.80 Cytochrome b5-like Heme/Steroid binding domain +HemY_N PF07219.6 134 jgi|Monbr1|4813|fgenesh1_pg.scaffold_2000129 - 283 0.29 10.1 1.5 1 2 0.047 1.9e+02 1.0 0.0 47 77 20 57 15 101 0.56 HemY protein N-terminus +HemY_N PF07219.6 134 jgi|Monbr1|4813|fgenesh1_pg.scaffold_2000129 - 283 0.29 10.1 1.5 2 2 0.00036 1.4 7.9 0.2 69 113 170 214 149 234 0.82 HemY protein N-terminus +RskA PF10099.2 175 jgi|Monbr1|4813|fgenesh1_pg.scaffold_2000129 - 283 0.81 9.0 7.3 1 2 0.00025 1 8.7 0.9 32 72 9 44 2 83 0.58 Anti-sigma-K factor rskA +RskA PF10099.2 175 jgi|Monbr1|4813|fgenesh1_pg.scaffold_2000129 - 283 0.81 9.0 7.3 2 2 0.0094 37 3.6 0.3 41 80 156 203 132 221 0.64 Anti-sigma-K factor rskA +HORMA PF02301.11 207 jgi|Monbr1|4816|fgenesh1_pg.scaffold_2000132 - 498 1.1e-22 80.1 0.0 1 1 3.4e-26 2e-22 79.3 0.0 5 206 50 278 47 279 0.81 HORMA domain +DUF605 PF04652.9 383 jgi|Monbr1|4816|fgenesh1_pg.scaffold_2000132 - 498 1.2 8.0 4.0 1 1 0.00022 1.3 7.9 2.7 175 294 308 425 136 449 0.66 Vta1 like +DSPc PF00782.13 133 jgi|Monbr1|4822|fgenesh1_pg.scaffold_2000138 - 510 5.1e-27 93.7 0.0 1 1 2.2e-30 8.9e-27 92.9 0.0 3 132 353 481 351 482 0.92 Dual specificity phosphatase, catalytic domain +Rhodanese PF00581.13 113 jgi|Monbr1|4822|fgenesh1_pg.scaffold_2000138 - 510 4.9e-08 32.9 0.0 1 2 1.1e-09 4.4e-06 26.7 0.0 11 109 201 306 191 309 0.76 Rhodanese-like domain +Rhodanese PF00581.13 113 jgi|Monbr1|4822|fgenesh1_pg.scaffold_2000138 - 510 4.9e-08 32.9 0.0 2 2 0.015 59 3.7 0.0 66 95 421 450 398 460 0.71 Rhodanese-like domain +Y_phosphatase PF00102.20 235 jgi|Monbr1|4822|fgenesh1_pg.scaffold_2000138 - 510 0.011 14.8 0.0 1 1 4.3e-06 0.017 14.1 0.0 146 198 403 450 371 465 0.76 Protein-tyrosine phosphatase +Homeobox PF00046.22 57 jgi|Monbr1|4837|fgenesh1_pg.scaffold_2000153 - 590 5.1e-09 35.3 0.3 1 1 5.9e-12 1.4e-08 33.9 0.2 4 54 263 316 261 318 0.88 Homeobox domain +Coprinus_mating PF05920.4 640 jgi|Monbr1|4837|fgenesh1_pg.scaffold_2000153 - 590 2e-06 26.1 2.0 1 1 1e-09 2.4e-06 25.8 0.5 118 172 262 317 215 355 0.73 Coprinus cinereus mating-type protein +Pox_A11 PF05061.6 314 jgi|Monbr1|4837|fgenesh1_pg.scaffold_2000153 - 590 0.064 12.0 0.3 1 1 4.4e-05 0.1 11.3 0.2 139 178 387 425 329 453 0.73 Poxvirus A11 Protein +Mitofilin PF09731.2 583 jgi|Monbr1|4837|fgenesh1_pg.scaffold_2000153 - 590 0.24 9.7 17.3 1 1 0.00018 0.42 8.9 12.0 85 318 173 454 136 460 0.66 Mitochondrial inner membrane protein +HAP1_N PF04849.6 307 jgi|Monbr1|4837|fgenesh1_pg.scaffold_2000153 - 590 0.44 9.1 9.8 1 1 0.00035 0.84 8.2 6.8 168 264 355 453 229 459 0.71 HAP1 N-terminal conserved region +LRR_1 PF00560.26 22 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 4.5e-08 31.7 3.0 1 5 0.00032 1.9 8.5 0.2 1 14 105 118 105 130 0.81 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 4.5e-08 31.7 3.0 2 5 0.0059 35 4.6 0.0 2 13 134 145 133 159 0.84 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 4.5e-08 31.7 3.0 3 5 0.0012 7.2 6.7 0.1 1 14 161 174 161 184 0.80 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 4.5e-08 31.7 3.0 4 5 0.046 2.8e+02 1.9 0.0 2 14 189 201 188 212 0.78 Leucine Rich Repeat +LRR_1 PF00560.26 22 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 4.5e-08 31.7 3.0 5 5 0.0052 31 4.8 0.0 1 15 216 242 216 250 0.73 Leucine Rich Repeat +LRR_2 PF07723.6 26 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 0.068 13.3 0.8 1 4 0.0072 43 4.5 0.0 3 26 47 70 45 70 0.93 Leucine Rich Repeat +LRR_2 PF07723.6 26 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 0.068 13.3 0.8 2 4 0.066 3.9e+02 1.5 0.1 2 14 106 118 105 124 0.81 Leucine Rich Repeat +LRR_2 PF07723.6 26 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 0.068 13.3 0.8 3 4 0.04 2.4e+02 2.1 0.0 1 15 133 147 133 154 0.82 Leucine Rich Repeat +LRR_2 PF07723.6 26 jgi|Monbr1|4839|fgenesh1_pg.scaffold_2000155 - 262 0.068 13.3 0.8 4 4 0.73 4.4e+03 -1.9 0.0 5 10 192 197 189 207 0.69 Leucine Rich Repeat +Sulfotransfer_2 PF03567.7 253 jgi|Monbr1|4844|fgenesh1_pg.scaffold_2000160 - 324 8.7e-08 31.8 0.0 1 1 2.2e-11 1.3e-07 31.2 0.0 11 110 64 181 62 265 0.84 Sulfotransferase family +Sulfotransfer_1 PF00685.20 257 jgi|Monbr1|4844|fgenesh1_pg.scaffold_2000160 - 324 0.016 14.3 0.2 1 2 2.8e-05 0.17 10.9 0.0 12 126 73 170 65 201 0.70 Sulfotransferase domain +Sulfotransfer_1 PF00685.20 257 jgi|Monbr1|4844|fgenesh1_pg.scaffold_2000160 - 324 0.016 14.3 0.2 2 2 0.044 2.6e+02 0.5 0.0 31 83 227 286 213 308 0.64 Sulfotransferase domain +Misat_Myo_SegII PF10644.2 101 jgi|Monbr1|4850|fgenesh1_pg.scaffold_2000166 - 412 5.8e-25 86.8 0.0 1 1 1.7e-28 1e-24 86.0 0.0 2 75 3 80 1 104 0.87 Misato Segment II myosin-like domain +Tubulin PF00091.18 216 jgi|Monbr1|4850|fgenesh1_pg.scaffold_2000166 - 412 1.4e-14 54.1 0.0 1 1 1.9e-17 1.1e-13 51.1 0.0 1 170 4 227 4 250 0.75 Tubulin/FtsZ family, GTPase domain +PH PF00169.22 104 jgi|Monbr1|4861|fgenesh1_pg.scaffold_2000177 - 239 2.8e-05 23.9 0.1 1 2 0.042 5e+02 0.6 0.0 13 29 83 99 65 113 0.82 PH domain +PH PF00169.22 104 jgi|Monbr1|4861|fgenesh1_pg.scaffold_2000177 - 239 2.8e-05 23.9 0.1 2 2 3.1e-08 0.00037 20.3 0.1 2 103 138 232 137 233 0.84 PH domain +HD-ZIP_N PF04618.5 112 jgi|Monbr1|4870|fgenesh1_pg.scaffold_2000186 - 300 0.015 15.4 0.6 1 2 5.7e-06 0.068 13.4 0.0 7 86 83 180 73 194 0.72 HD-ZIP protein N terminus +HD-ZIP_N PF04618.5 112 jgi|Monbr1|4870|fgenesh1_pg.scaffold_2000186 - 300 0.015 15.4 0.6 2 2 0.095 1.1e+03 -0.2 0.3 44 70 223 243 186 259 0.54 HD-ZIP protein N terminus +MAD PF05557.6 722 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.4 8.4 40.9 1 3 2.7e-05 0.11 10.3 10.7 97 200 240 347 232 350 0.91 Mitotic checkpoint protein +MAD PF05557.6 722 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.4 8.4 40.9 2 3 0.0092 37 1.9 5.5 177 248 369 429 357 471 0.54 Mitotic checkpoint protein +MAD PF05557.6 722 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.4 8.4 40.9 3 3 0.00014 0.54 7.9 1.4 455 514 589 648 572 677 0.81 Mitotic checkpoint protein +AIP3 PF03915.6 422 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.73 8.3 20.6 1 2 2.7e-06 0.011 14.3 5.8 57 197 286 424 277 446 0.85 Actin interacting protein 3 +AIP3 PF03915.6 422 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.73 8.3 20.6 2 2 0.031 1.2e+02 1.0 1.4 109 181 581 655 557 672 0.54 Actin interacting protein 3 +Reo_sigmaC PF04582.5 326 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.78 8.5 11.8 1 3 3.3e-05 0.13 11.1 0.6 39 123 261 343 227 363 0.78 Reovirus sigma C capsid protein +Reo_sigmaC PF04582.5 326 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.78 8.5 11.8 2 3 0.023 90 1.7 0.1 134 158 405 429 372 442 0.66 Reovirus sigma C capsid protein +Reo_sigmaC PF04582.5 326 jgi|Monbr1|4873|fgenesh1_pg.scaffold_2000189 - 783 0.78 8.5 11.8 3 3 0.032 1.3e+02 1.2 0.2 56 100 584 628 571 653 0.60 Reovirus sigma C capsid protein +Ank PF00023.23 33 jgi|Monbr1|4877|fgenesh1_pg.scaffold_2000193 - 371 7.3e-13 47.3 10.6 1 4 1.7e-06 0.0098 15.3 0.1 4 23 42 61 40 64 0.94 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|4877|fgenesh1_pg.scaffold_2000193 - 371 7.3e-13 47.3 10.6 2 4 9.7e-09 5.8e-05 22.3 0.0 3 32 94 123 94 124 0.97 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|4877|fgenesh1_pg.scaffold_2000193 - 371 7.3e-13 47.3 10.6 3 4 0.00036 2.1 7.9 0.4 3 26 127 182 126 186 0.67 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|4877|fgenesh1_pg.scaffold_2000193 - 371 7.3e-13 47.3 10.6 4 4 0.011 68 3.2 0.2 1 32 294 328 294 329 0.87 Ankyrin repeat +CDKN3 PF05706.5 207 jgi|Monbr1|4877|fgenesh1_pg.scaffold_2000193 - 371 0.0016 17.4 0.0 1 1 5.3e-07 0.0032 16.5 0.0 89 152 284 349 272 370 0.65 Cyclin-dependent kinase inhibitor 3 (CDKN3) +DUF1167 PF06657.6 273 jgi|Monbr1|4878|fgenesh1_pg.scaffold_2000194 - 766 3.2e-07 29.7 0.5 1 2 0.11 4.3e+02 -0.2 0.1 191 228 436 473 418 510 0.74 Protein of unknown function (DUF1167) +DUF1167 PF06657.6 273 jgi|Monbr1|4878|fgenesh1_pg.scaffold_2000194 - 766 3.2e-07 29.7 0.5 2 2 6.5e-10 2.6e-06 26.7 0.0 136 182 677 724 662 756 0.80 Protein of unknown function (DUF1167) +DinI PF06183.6 65 jgi|Monbr1|4878|fgenesh1_pg.scaffold_2000194 - 766 0.051 13.2 0.1 1 1 2.7e-05 0.11 12.2 0.0 6 44 462 499 458 505 0.87 DinI-like family +DivIVA PF05103.6 131 jgi|Monbr1|4878|fgenesh1_pg.scaffold_2000194 - 766 0.15 11.8 4.0 1 3 0.62 2.5e+03 -1.9 0.0 34 83 42 91 37 119 0.58 DivIVA protein +DivIVA PF05103.6 131 jgi|Monbr1|4878|fgenesh1_pg.scaffold_2000194 - 766 0.15 11.8 4.0 2 3 1.3 5.3e+03 -3.0 0.0 66 98 399 431 389 437 0.84 DivIVA protein +DivIVA PF05103.6 131 jgi|Monbr1|4878|fgenesh1_pg.scaffold_2000194 - 766 0.15 11.8 4.0 3 3 3.3e-05 0.13 12.0 0.6 27 102 455 526 447 541 0.62 DivIVA protein +MMtag PF10159.2 78 jgi|Monbr1|4886|fgenesh1_pg.scaffold_2000202 - 365 6.2e-24 83.5 4.3 1 1 2.2e-27 1.3e-23 82.4 3.0 1 78 11 99 11 99 0.87 Kinase phosphorylation protein +Trp_oprn_chp PF09534.3 189 jgi|Monbr1|4886|fgenesh1_pg.scaffold_2000202 - 365 1.2 8.4 4.9 1 1 0.00041 2.4 7.3 3.4 29 113 263 350 255 360 0.83 Tryptophan-associated transmembrane protein (Trp_oprn_chp) +DUF1604 PF07713.6 87 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 1e-30 105.0 3.7 1 3 3.4e-34 1e-30 105.0 2.6 2 86 25 124 24 125 0.90 Protein of unknown function (DUF1604) +DUF1604 PF07713.6 87 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 1e-30 105.0 3.7 2 3 1.9 5.6e+03 -3.2 1.5 48 73 611 635 608 648 0.51 Protein of unknown function (DUF1604) +DUF1604 PF07713.6 87 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 1e-30 105.0 3.7 3 3 1 3.1e+03 -2.3 0.3 49 68 643 662 634 677 0.49 Protein of unknown function (DUF1604) +G-patch PF01585.16 45 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 3.2e-07 29.7 3.0 1 1 2.6e-10 7.8e-07 28.4 2.1 2 22 160 186 159 209 0.73 G-patch domain +IR1-M PF12185.1 64 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 0.47 9.9 4.0 1 2 0.18 5.3e+02 0.1 0.0 39 53 104 118 97 123 0.80 Nup358/RanBP2 E3 ligase domain +IR1-M PF12185.1 64 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 0.47 9.9 4.0 2 2 0.00041 1.2 8.5 0.8 12 52 419 463 415 474 0.79 Nup358/RanBP2 E3 ligase domain +BUD22 PF09073.3 430 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 1.4 7.5 26.1 1 2 0.0049 15 4.2 5.8 141 256 368 487 344 493 0.59 BUD22 +BUD22 PF09073.3 430 jgi|Monbr1|4895|fgenesh1_pg.scaffold_2000211 - 728 1.4 7.5 26.1 2 2 0.00019 0.56 8.8 6.8 147 212 610 673 601 724 0.59 BUD22 +Bromodomain PF00439.18 84 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 5.4e-37 125.2 0.1 1 3 1e-12 2.4e-09 36.6 0.0 32 83 1016 1067 990 1068 0.88 Bromodomain +Bromodomain PF00439.18 84 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 5.4e-37 125.2 0.1 2 3 9.5e-14 2.3e-10 39.9 0.0 3 73 1261 1331 1259 1340 0.88 Bromodomain +Bromodomain PF00439.18 84 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 5.4e-37 125.2 0.1 3 3 2.9e-15 7e-12 44.7 0.0 1 78 1393 1472 1393 1478 0.95 Bromodomain +WD40 PF00400.25 39 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 1.8e-25 87.5 12.6 1 6 1.4e-06 0.0035 16.8 0.1 4 38 115 149 112 150 0.94 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 1.8e-25 87.5 12.6 2 6 2.2e-07 0.00052 19.5 0.0 3 39 156 192 154 192 0.96 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 1.8e-25 87.5 12.6 3 6 1.5e-07 0.00037 19.9 0.2 1 38 196 235 196 236 0.96 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 1.8e-25 87.5 12.6 4 6 2.1 5.1e+03 -2.7 0.0 18 29 284 295 284 296 0.89 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 1.8e-25 87.5 12.6 5 6 1.4e-05 0.033 13.7 0.0 3 35 315 347 313 349 0.89 WD domain, G-beta repeat +WD40 PF00400.25 39 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 1.8e-25 87.5 12.6 6 6 4.1e-08 9.8e-05 21.8 0.0 5 39 414 449 411 449 0.95 WD domain, G-beta repeat +Auxin_resp PF06507.6 83 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 3.6e-08 32.8 0.0 1 1 4.8e-11 1.2e-07 31.2 0.0 21 81 857 912 843 914 0.91 Auxin response factor +Prim-Pol PF09250.4 162 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 0.11 12.2 0.1 1 1 0.00011 0.27 10.8 0.1 30 136 379 486 354 510 0.73 Bifunctional DNA primase/polymerase, N-terminal +FbpA PF05833.4 453 jgi|Monbr1|4901|fgenesh1_pg.scaffold_2000217 - 1722 0.76 7.9 3.8 1 1 0.00056 1.3 7.1 2.6 255 331 575 650 522 673 0.77 Fibronectin-binding protein A N-terminus (FbpA) +DUF1565 PF07602.4 243 jgi|Monbr1|4912|fgenesh1_pg.scaffold_2000228 - 644 0.00064 18.6 6.1 1 2 4.7e-07 0.0056 15.5 0.5 2 44 37 84 36 93 0.80 Protein of unknown function (DUF1565) +DUF1565 PF07602.4 243 jgi|Monbr1|4912|fgenesh1_pg.scaffold_2000228 - 644 0.00064 18.6 6.1 2 2 0.00051 6.1 5.5 0.4 107 188 355 474 302 506 0.72 Protein of unknown function (DUF1565) +Ion_trans PF00520.24 201 jgi|Monbr1|4929|fgenesh1_pg.scaffold_2000245 - 167 0.037 13.0 0.7 1 1 5.3e-06 0.064 12.2 0.5 60 84 119 143 90 151 0.60 Ion transport protein +Acetyltransf_1 PF00583.17 83 jgi|Monbr1|4934|fgenesh1_pg.scaffold_2000250 - 181 2.2e-05 24.0 0.0 1 1 8.8e-09 3.5e-05 23.4 0.0 4 62 110 166 107 177 0.84 Acetyltransferase (GNAT) family +DUF448 PF04296.6 78 jgi|Monbr1|4934|fgenesh1_pg.scaffold_2000250 - 181 0.0036 16.5 0.0 1 2 0.88 3.5e+03 -2.6 0.0 39 50 3 14 3 16 0.82 Protein of unknown function (DUF448) +DUF448 PF04296.6 78 jgi|Monbr1|4934|fgenesh1_pg.scaffold_2000250 - 181 0.0036 16.5 0.0 2 2 2.5e-06 0.0098 15.1 0.0 31 66 119 154 104 165 0.79 Protein of unknown function (DUF448) +ACT PF01842.18 66 jgi|Monbr1|4934|fgenesh1_pg.scaffold_2000250 - 181 0.085 12.0 0.1 1 1 3.9e-05 0.15 11.2 0.1 30 64 46 77 44 79 0.89 ACT domain +TGT PF01702.11 238 jgi|Monbr1|4956|fgenesh1_pg.scaffold_2000272 - 364 7.1e-56 188.8 0.0 1 1 1.1e-59 1.3e-55 187.9 0.0 1 147 150 296 150 298 0.98 Queuine tRNA-ribosyltransferase +DDE PF03184.12 217 jgi|Monbr1|4959|fgenesh1_pg.scaffold_2000275 - 734 8.2e-05 21.5 0.0 1 1 2.9e-08 0.00017 20.4 0.0 23 160 280 425 262 441 0.76 DDE superfamily endonuclease +KAR9 PF08580.3 683 jgi|Monbr1|4959|fgenesh1_pg.scaffold_2000275 - 734 1.2 6.9 6.2 1 1 0.00031 1.9 6.3 4.3 531 640 465 587 436 617 0.74 Yeast cortical protein KAR9 +Med26 PF08711.4 53 jgi|Monbr1|4962|fgenesh1_pg.scaffold_2000278 - 312 0.015 14.4 0.0 1 1 7e-06 0.028 13.6 0.0 2 21 96 115 95 132 0.88 TFIIS helical bundle-like domain +DUF2686 PF10887.1 276 jgi|Monbr1|4962|fgenesh1_pg.scaffold_2000278 - 312 0.059 11.7 0.0 1 2 5.1e-05 0.2 10.0 0.0 45 131 59 144 34 154 0.79 Protein of unknown function (DUF2686) +DUF2686 PF10887.1 276 jgi|Monbr1|4962|fgenesh1_pg.scaffold_2000278 - 312 0.059 11.7 0.0 2 2 0.12 4.6e+02 -1.0 0.0 182 230 162 207 158 212 0.73 Protein of unknown function (DUF2686) +DUF1466 PF07326.4 234 jgi|Monbr1|4962|fgenesh1_pg.scaffold_2000278 - 312 0.074 12.0 0.1 1 1 5e-05 0.2 10.6 0.1 177 229 34 85 19 90 0.86 Protein of unknown function (DUF1466) +TMC PF07810.6 111 jgi|Monbr1|4964|fgenesh1_pg.scaffold_2000280 - 1124 0.00043 20.3 0.4 1 2 2 1.2e+04 -4.3 0.6 77 92 743 758 738 763 0.77 TMC domain +TMC PF07810.6 111 jgi|Monbr1|4964|fgenesh1_pg.scaffold_2000280 - 1124 0.00043 20.3 0.4 2 2 7.2e-08 0.00043 20.3 0.3 1 30 904 933 904 993 0.89 TMC domain +FA_desaturase PF00487.17 257 jgi|Monbr1|4964|fgenesh1_pg.scaffold_2000280 - 1124 0.35 9.9 2.7 1 2 0.00084 5 6.1 0.0 87 176 597 689 579 711 0.80 Fatty acid desaturase +FA_desaturase PF00487.17 257 jgi|Monbr1|4964|fgenesh1_pg.scaffold_2000280 - 1124 0.35 9.9 2.7 2 2 0.026 1.5e+02 1.3 1.2 95 176 911 1000 887 1025 0.63 Fatty acid desaturase +DNAP_B_exo_N PF08452.3 22 jgi|Monbr1|4967|fgenesh1_pg.scaffold_2000283 - 415 0.44 9.5 1.9 1 1 0.00012 1.5 7.8 1.3 6 19 218 231 212 233 0.84 DNA polymerase family B exonuclease domain, N-terminal +AP_endonuc_2 PF01261.17 211 jgi|Monbr1|4973|fgenesh1_pg.scaffold_2000289 - 259 4.3e-32 110.8 1.0 1 1 4.9e-36 5.8e-32 110.4 0.7 1 205 22 214 22 238 0.93 Xylose isomerase-like TIM barrel +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 1 8 9.2e-15 1.4e-11 44.0 0.0 2 139 804 962 803 962 0.85 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 2 8 8.5e-08 0.00013 21.4 0.0 10 99 1296 1387 1288 1425 0.77 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 3 8 1.6e-09 2.4e-06 26.9 0.0 3 138 1573 1707 1571 1708 0.85 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 4 8 0.014 21 4.5 0.0 10 47 1892 1929 1885 1941 0.88 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 5 8 8.5e-06 0.013 14.9 0.0 50 139 2148 2232 2134 2232 0.91 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 6 8 6.1e-09 9.1e-06 25.1 0.0 3 87 2416 2501 2415 2517 0.93 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 7 8 2.7e-05 0.04 13.3 0.0 2 81 2728 2809 2727 2832 0.85 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 4.3e-54 181.7 0.0 8 8 4.8e-07 0.00071 19.0 0.0 52 137 2900 2980 2883 2982 0.84 AAA domain (dynein-related subfamily) +VWA PF00092.21 179 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 1.3e-06 27.8 0.0 1 3 6.7e-06 0.0099 15.2 0.0 2 148 6437 6592 6436 6606 0.78 von Willebrand factor type A domain +VWA PF00092.21 179 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 1.3e-06 27.8 0.0 2 3 0.25 3.7e+02 0.4 0.0 5 141 6802 6937 6801 6959 0.76 von Willebrand factor type A domain +VWA PF00092.21 179 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 1.3e-06 27.8 0.0 3 3 0.003 4.4 6.6 0.0 1 109 7041 7157 7041 7171 0.62 von Willebrand factor type A domain +AAA_3 PF07726.4 131 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 5.6e-06 25.6 0.0 1 4 0.0087 13 5.0 0.0 2 101 804 906 803 935 0.73 ATPase family associated with various cellular activities (AAA) +AAA_3 PF07726.4 131 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 5.6e-06 25.6 0.0 2 4 0.0076 11 5.2 0.0 10 67 1296 1353 1289 1375 0.87 ATPase family associated with various cellular activities (AAA) +AAA_3 PF07726.4 131 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 5.6e-06 25.6 0.0 3 4 0.011 16 4.8 0.0 6 125 1576 1704 1572 1710 0.68 ATPase family associated with various cellular activities (AAA) +AAA_3 PF07726.4 131 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 5.6e-06 25.6 0.0 4 4 0.02 29 3.9 0.0 3 62 2416 2474 2415 2503 0.86 ATPase family associated with various cellular activities (AAA) +DUF1194 PF06707.4 206 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.0044 15.6 1.8 1 3 0.028 42 2.7 0.1 2 25 6433 6456 6432 6606 0.75 Protein of unknown function (DUF1194) +DUF1194 PF06707.4 206 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.0044 15.6 1.8 2 3 0.00078 1.2 7.7 0.0 80 163 6865 6945 6853 6961 0.84 Protein of unknown function (DUF1194) +DUF1194 PF06707.4 206 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.0044 15.6 1.8 3 3 0.058 87 1.6 0.0 1 87 7037 7122 7037 7150 0.73 Protein of unknown function (DUF1194) +Alpha-2-MRAP_C PF06401.4 205 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.038 13.4 0.6 1 2 0.00023 0.34 10.3 0.2 101 150 3224 3273 3193 3286 0.81 Alpha-2-macroglobulin RAP, C-terminal domain +Alpha-2-MRAP_C PF06401.4 205 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.038 13.4 0.6 2 2 0.46 6.8e+02 -0.5 0.0 22 54 6699 6731 6695 6780 0.79 Alpha-2-macroglobulin RAP, C-terminal domain +Sec39 PF08314.4 713 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.1 10.1 0.3 1 1 0.00022 0.32 8.5 0.2 208 347 30 181 19 198 0.64 Secretory pathway protein Sec39 +UPF0079 PF02367.10 123 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.13 11.5 4.3 1 5 0.67 1e+03 -1.0 0.0 18 30 804 816 794 822 0.89 Uncharacterised P-loop hydrolase UPF0079 +UPF0079 PF02367.10 123 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.13 11.5 4.3 2 5 5.2 7.7e+03 -3.9 0.0 20 40 1574 1595 1573 1598 0.82 Uncharacterised P-loop hydrolase UPF0079 +UPF0079 PF02367.10 123 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.13 11.5 4.3 3 5 0.0017 2.5 7.4 0.0 7 45 2404 2442 2399 2448 0.88 Uncharacterised P-loop hydrolase UPF0079 +UPF0079 PF02367.10 123 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.13 11.5 4.3 4 5 0.092 1.4e+02 1.8 0.1 13 37 2723 2747 2714 2759 0.81 Uncharacterised P-loop hydrolase UPF0079 +UPF0079 PF02367.10 123 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 0.13 11.5 4.3 5 5 1.4 2.2e+03 -2.1 0.0 84 109 4541 4566 4528 4576 0.75 Uncharacterised P-loop hydrolase UPF0079 +Rabaptin PF03528.8 106 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 1.2 8.7 4.2 1 2 0.029 43 3.7 0.2 47 97 2791 2841 2781 2849 0.77 Rabaptin +Rabaptin PF03528.8 106 jgi|Monbr1|4977|fgenesh1_pg.scaffold_2000293 - 7261 1.2 8.7 4.2 2 2 0.027 40 3.8 0.3 38 88 3697 3754 3662 3768 0.63 Rabaptin +RRM_1 PF00076.15 70 jgi|Monbr1|4979|fgenesh1_pg.scaffold_2000295 - 868 2e-07 30.1 0.0 1 1 8.6e-11 3.4e-07 29.4 0.0 1 69 556 618 556 619 0.94 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) +DUF618 PF04818.6 64 jgi|Monbr1|4979|fgenesh1_pg.scaffold_2000295 - 868 0.00017 21.4 0.4 1 1 7.5e-08 0.0003 20.6 0.3 15 63 82 129 72 130 0.90 Protein of unknown function, DUF618 +U1snRNP70_N PF12220.1 94 jgi|Monbr1|4979|fgenesh1_pg.scaffold_2000295 - 868 1.2 9.1 6.0 1 2 1.8 7e+03 -2.9 0.0 34 55 246 267 243 275 0.76 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal +U1snRNP70_N PF12220.1 94 jgi|Monbr1|4979|fgenesh1_pg.scaffold_2000295 - 868 1.2 9.1 6.0 2 2 0.00059 2.4 8.2 3.3 20 74 330 385 326 388 0.71 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal +AAA PF00004.22 130 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.1e-46 157.9 0.1 1 5 0.0016 0.61 10.0 0.0 1 22 841 862 841 899 0.77 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.1e-46 157.9 0.1 2 5 9 3.4e+03 -2.2 0.1 42 73 1096 1124 1071 1138 0.71 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.1e-46 157.9 0.1 3 5 1.5e-12 5.6e-10 39.2 0.0 3 126 1991 2118 1989 2122 0.77 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.1e-46 157.9 0.1 4 5 2.9e-14 1.1e-11 44.7 0.0 2 112 2389 2506 2388 2523 0.82 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.1e-46 157.9 0.1 5 5 8.8e-18 3.4e-15 56.1 0.0 2 129 2662 2794 2661 2795 0.86 ATPase family associated with various cellular activities (AAA) +AAA_5 PF07728.7 139 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 4.1e-12 45.6 0.9 1 4 0.0055 2.1 7.7 0.0 2 24 841 864 840 876 0.79 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 4.1e-12 45.6 0.9 2 4 0.0037 1.4 8.3 0.0 4 24 1991 2012 1988 2082 0.73 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 4.1e-12 45.6 0.9 3 4 0.00025 0.094 12.1 0.0 3 74 2389 2457 2387 2464 0.84 AAA domain (dynein-related subfamily) +AAA_5 PF07728.7 139 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 4.1e-12 45.6 0.9 4 4 0.0002 0.077 12.4 0.0 3 78 2662 2734 2660 2780 0.86 AAA domain (dynein-related subfamily) +DUF2075 PF09848.2 352 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 36.7 2.7 1 5 5.6e-07 0.00022 20.0 0.0 2 54 839 896 838 916 0.75 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 36.7 2.7 2 5 0.039 15 4.1 0.0 325 348 1420 1443 1393 1445 0.80 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 36.7 2.7 3 5 0.15 57 2.2 0.0 7 20 1992 2005 1989 2014 0.88 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 36.7 2.7 4 5 0.65 2.5e+02 0.1 0.0 8 18 2392 2402 2389 2411 0.90 Uncharacterized conserved protein (DUF2075) +DUF2075 PF09848.2 352 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 36.7 2.7 5 5 0.062 24 3.4 0.0 5 20 2662 2677 2659 2699 0.86 Uncharacterized conserved protein (DUF2075) +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 37.2 0.1 1 6 0.59 2.3e+02 0.9 0.0 2 22 842 863 841 894 0.81 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 37.2 0.1 2 6 0.27 1.1e+02 2.0 0.0 58 99 1108 1147 1066 1165 0.77 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 37.2 0.1 3 6 0.025 9.7 5.3 0.0 176 225 1392 1444 1340 1445 0.72 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 37.2 0.1 4 6 0.0006 0.23 10.7 0.0 5 71 1993 2063 1991 2069 0.89 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 37.2 0.1 5 6 0.32 1.2e+02 1.7 0.0 5 71 2392 2461 2389 2465 0.57 Viral (Superfamily 1) RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.8e-09 37.2 0.1 6 6 0.0091 3.5 6.8 0.0 3 72 2663 2735 2661 2738 0.73 Viral (Superfamily 1) RNA helicase +Mg_chelatase PF01078.14 207 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.3e-09 36.4 2.2 1 6 0.022 8.5 5.1 0.0 24 53 840 869 822 894 0.77 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.3e-09 36.4 2.2 2 6 0.012 4.5 6.0 0.0 23 50 1987 2014 1980 2035 0.85 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.3e-09 36.4 2.2 3 6 0.0099 3.8 6.3 0.0 25 49 2388 2412 2385 2425 0.88 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.3e-09 36.4 2.2 4 6 0.49 1.9e+02 0.7 0.0 89 116 2431 2458 2421 2464 0.87 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.3e-09 36.4 2.2 5 6 0.00093 0.36 9.6 0.0 23 45 2659 2681 2647 2700 0.84 Magnesium chelatase, subunit ChlI +Mg_chelatase PF01078.14 207 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.3e-09 36.4 2.2 6 6 0.89 3.4e+02 -0.1 0.0 90 120 2705 2735 2695 2745 0.80 Magnesium chelatase, subunit ChlI +Sigma54_activat PF00158.19 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.3e-08 34.1 0.7 1 4 0.0027 1 8.5 0.0 16 68 832 887 818 892 0.69 Sigma-54 interaction domain +Sigma54_activat PF00158.19 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.3e-08 34.1 0.7 2 4 0.094 36 3.4 0.0 21 56 1985 2025 1965 2032 0.73 Sigma-54 interaction domain +Sigma54_activat PF00158.19 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.3e-08 34.1 0.7 3 4 0.0075 2.9 7.0 0.0 21 107 2384 2462 2373 2467 0.77 Sigma-54 interaction domain +Sigma54_activat PF00158.19 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 1.3e-08 34.1 0.7 4 4 0.0045 1.7 7.7 0.0 23 115 2659 2743 2641 2793 0.66 Sigma-54 interaction domain +RNA_helicase PF00910.15 107 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.6e-07 30.4 0.3 1 4 0.0061 2.3 8.1 0.0 1 30 841 870 841 888 0.85 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.6e-07 30.4 0.3 2 4 0.22 85 3.0 0.0 3 26 1991 2013 1989 2051 0.68 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.6e-07 30.4 0.3 3 4 0.11 42 4.0 0.0 3 37 2390 2423 2389 2436 0.77 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.6e-07 30.4 0.3 4 4 0.004 1.5 8.6 0.0 2 51 2662 2709 2661 2712 0.80 RNA helicase +IstB PF01695.10 178 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3e-07 29.7 0.1 1 4 8.8e-05 0.034 13.2 0.0 37 75 828 866 796 880 0.76 IstB-like ATP binding protein +IstB PF01695.10 178 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3e-07 29.7 0.1 2 4 0.43 1.7e+02 1.2 0.0 48 65 1987 2004 1965 2009 0.87 IstB-like ATP binding protein +IstB PF01695.10 178 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3e-07 29.7 0.1 3 4 0.19 74 2.3 0.0 48 64 2386 2402 2374 2415 0.85 IstB-like ATP binding protein +IstB PF01695.10 178 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3e-07 29.7 0.1 4 4 0.014 5.3 6.1 0.0 48 69 2659 2680 2648 2687 0.90 IstB-like ATP binding protein +KaiC PF06745.6 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.2e-06 26.6 0.5 1 4 0.00087 0.33 9.6 0.0 17 40 836 859 829 871 0.85 KaiC +KaiC PF06745.6 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.2e-06 26.6 0.5 2 4 0.0023 0.87 8.3 0.0 8 39 1974 2006 1970 2008 0.90 KaiC +KaiC PF06745.6 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.2e-06 26.6 0.5 3 4 0.48 1.8e+02 0.7 0.0 25 37 2391 2403 2386 2406 0.84 KaiC +KaiC PF06745.6 226 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 2.2e-06 26.6 0.5 4 4 0.21 81 1.8 0.0 25 37 2664 2676 2657 2679 0.87 KaiC +PhoH PF02562.9 205 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.6e-06 25.4 5.9 1 4 3.9e-07 0.00015 20.7 0.1 7 49 826 868 822 877 0.84 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.6e-06 25.4 5.9 2 4 0.36 1.4e+02 1.2 0.0 22 40 1989 2007 1980 2014 0.83 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.6e-06 25.4 5.9 3 4 1.1 4.1e+02 -0.3 0.0 24 39 2390 2405 2384 2410 0.85 PhoH-like protein +PhoH PF02562.9 205 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.6e-06 25.4 5.9 4 4 0.28 1.1e+02 1.6 0.1 23 40 2662 2679 2647 2686 0.82 PhoH-like protein +RuvB_N PF05496.5 234 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3.3e-05 22.7 0.7 1 5 0.032 12 4.4 0.0 39 72 821 860 810 873 0.70 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3.3e-05 22.7 0.7 2 5 0.15 58 2.2 0.0 52 70 1988 2006 1947 2065 0.73 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3.3e-05 22.7 0.7 3 5 0.011 4.2 6.0 0.0 34 73 2370 2408 2359 2464 0.77 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3.3e-05 22.7 0.7 4 5 4 1.5e+03 -2.4 0.0 166 205 2515 2556 2506 2573 0.69 Holliday junction DNA helicase ruvB N-terminus +RuvB_N PF05496.5 234 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 3.3e-05 22.7 0.7 5 5 0.083 32 3.1 0.0 52 70 2660 2678 2609 2697 0.66 Holliday junction DNA helicase ruvB N-terminus +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 1 8 0.0039 1.5 7.9 0.0 2 27 840 864 839 888 0.83 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 2 8 5.7 2.2e+03 -2.4 0.0 117 142 1273 1298 1252 1304 0.82 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 3 8 7.9 3.1e+03 -2.9 0.0 6 17 1992 2003 1991 2005 0.88 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 4 8 0.24 94 2.0 0.0 75 102 2046 2071 2011 2115 0.79 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 5 8 2.7 1e+03 -1.4 0.0 4 17 2389 2402 2388 2404 0.89 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 6 8 0.52 2e+02 1.0 0.0 78 102 2447 2471 2436 2525 0.82 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 7 8 0.57 2.2e+02 0.8 0.0 4 17 2662 2675 2661 2680 0.90 Zonular occludens toxin (Zot) +Zot PF05707.5 193 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 5.2e-05 22.4 2.9 8 8 0.19 74 2.4 0.0 77 107 2718 2747 2705 2755 0.78 Zonular occludens toxin (Zot) +NACHT PF05729.5 166 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00016 20.9 1.0 1 5 0.0039 1.5 8.1 0.0 1 32 839 870 839 899 0.77 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00016 20.9 1.0 2 5 1.6 6.2e+02 -0.4 0.0 70 100 1427 1462 1408 1496 0.78 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00016 20.9 1.0 3 5 0.25 95 2.2 0.0 5 19 1991 2005 1988 2048 0.86 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00016 20.9 1.0 4 5 1.7 6.5e+02 -0.5 0.0 5 18 2390 2403 2388 2405 0.86 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00016 20.9 1.0 5 5 0.13 51 3.1 0.0 4 20 2662 2678 2660 2687 0.88 NACHT domain +UvrD-helicase PF00580.14 533 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00019 19.9 0.1 1 3 3.6e-06 0.0014 17.1 0.0 3 57 826 884 824 946 0.88 UvrD/REP helicase +UvrD-helicase PF00580.14 533 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00019 19.9 0.1 2 3 4.5 1.7e+03 -3.1 0.1 365 422 1064 1118 1024 1144 0.53 UvrD/REP helicase +UvrD-helicase PF00580.14 533 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00019 19.9 0.1 3 3 8.2 3.2e+03 -3.9 0.0 16 29 2388 2401 2378 2405 0.78 UvrD/REP helicase +Torsin PF06309.4 127 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00035 20.1 0.0 1 4 0.07 27 4.3 0.0 55 85 840 870 817 883 0.79 Torsin +Torsin PF06309.4 127 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00035 20.1 0.0 2 4 2.8 1.1e+03 -0.8 0.0 54 71 1987 2004 1964 2008 0.83 Torsin +Torsin PF06309.4 127 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00035 20.1 0.0 3 4 0.022 8.4 5.9 0.0 35 85 2366 2417 2344 2450 0.79 Torsin +Torsin PF06309.4 127 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.00035 20.1 0.0 4 4 0.16 61 3.2 0.0 56 89 2661 2695 2640 2701 0.77 Torsin +DEAD PF00270.22 167 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0034 16.5 0.0 1 2 5.6e-05 0.021 13.9 0.0 3 52 827 878 825 928 0.75 DEAD/DEAH box helicase +DEAD PF00270.22 167 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0034 16.5 0.0 2 2 4.7 1.8e+03 -2.1 0.0 43 44 2419 2464 2387 2516 0.46 DEAD/DEAH box helicase +Zeta_toxin PF06414.5 201 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0061 15.3 3.5 1 4 0.0024 0.94 8.2 0.0 7 40 829 862 823 873 0.81 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0061 15.3 3.5 2 4 2.9 1.1e+03 -1.8 0.1 23 34 1993 2004 1992 2007 0.90 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0061 15.3 3.5 3 4 0.8 3.1e+02 -0.0 0.0 23 35 2392 2404 2388 2413 0.87 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0061 15.3 3.5 4 4 0.044 17 4.1 0.0 19 40 2661 2682 2645 2701 0.83 Zeta toxin +KTI12 PF08433.3 270 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0078 15.1 0.6 1 4 0.19 72 2.1 0.0 4 28 841 869 839 882 0.76 Chromatin associated protein KTI12 +KTI12 PF08433.3 270 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0078 15.1 0.6 2 4 0.89 3.4e+02 -0.1 0.0 6 27 1991 2012 1989 2025 0.84 Chromatin associated protein KTI12 +KTI12 PF08433.3 270 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0078 15.1 0.6 3 4 0.72 2.8e+02 0.2 0.0 6 24 2390 2408 2389 2427 0.81 Chromatin associated protein KTI12 +KTI12 PF08433.3 270 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.0078 15.1 0.6 4 4 0.011 4 6.2 0.0 5 25 2662 2682 2661 2704 0.87 Chromatin associated protein KTI12 +GSPII_E PF00437.13 282 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.011 14.3 0.2 1 3 0.0019 0.74 8.3 0.0 123 161 824 865 788 876 0.75 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.011 14.3 0.2 2 3 1.9 7.2e+02 -1.5 0.0 127 155 2377 2402 2356 2410 0.72 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.011 14.3 0.2 3 3 0.23 87 1.5 0.0 138 156 2658 2676 2632 2692 0.81 Type II/IV secretion system protein +ResIII PF04851.8 184 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.011 15.2 0.6 1 3 0.0005 0.19 11.2 0.0 8 70 828 892 815 945 0.78 Type III restriction enzyme, res subunit +ResIII PF04851.8 184 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.011 15.2 0.6 2 3 6.5 2.5e+03 -2.3 0.0 31 44 1992 2005 1982 2016 0.77 Type III restriction enzyme, res subunit +ResIII PF04851.8 184 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.011 15.2 0.6 3 3 4.9 1.9e+03 -1.9 0.0 29 43 2662 2676 2651 2688 0.81 Type III restriction enzyme, res subunit +DUF265 PF03266.8 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.014 14.8 1.7 1 4 0.82 3.1e+02 0.6 0.0 2 24 841 867 840 874 0.61 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.014 14.8 1.7 2 4 0.32 1.2e+02 1.9 0.0 6 23 1993 2010 1988 2016 0.77 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.014 14.8 1.7 3 4 0.64 2.5e+02 0.9 0.0 6 23 2392 2409 2388 2420 0.76 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.014 14.8 1.7 4 4 0.015 5.7 6.3 0.0 3 20 2662 2679 2660 2687 0.82 Protein of unknown function, DUF265 +DUF815 PF05673.6 250 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.029 13.0 0.8 1 5 1.6 6e+02 -1.2 0.0 54 82 839 871 811 880 0.72 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.029 13.0 0.8 2 5 9.6 3.7e+03 -3.8 0.0 30 70 1955 2003 1931 2007 0.50 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.029 13.0 0.8 3 5 2.4 9.1e+02 -1.8 0.0 52 71 2384 2403 2348 2411 0.79 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.029 13.0 0.8 4 5 0.075 29 3.1 0.0 39 82 2644 2687 2616 2703 0.75 Protein of unknown function (DUF815) +DUF815 PF05673.6 250 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.029 13.0 0.8 5 5 0.032 12 4.3 0.0 173 246 2774 2851 2767 2855 0.88 Protein of unknown function (DUF815) +MobB PF03205.7 137 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.035 13.5 0.4 1 4 0.41 1.6e+02 1.7 0.0 2 31 840 873 839 880 0.72 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.035 13.5 0.4 2 4 1.4 5.3e+02 0.0 0.0 6 25 1992 2011 1988 2018 0.77 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.035 13.5 0.4 3 4 0.38 1.5e+02 1.8 0.0 5 26 2390 2411 2388 2415 0.83 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.035 13.5 0.4 4 4 0.15 57 3.1 0.0 4 20 2662 2678 2660 2690 0.85 Molybdopterin guanine dinucleotide synthesis protein B +APS_kinase PF01583.13 157 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.055 12.8 0.5 1 5 5 1.9e+03 -2.0 0.0 4 30 840 866 838 874 0.74 Adenylylsulphate kinase +APS_kinase PF01583.13 157 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.055 12.8 0.5 2 5 0.65 2.5e+02 0.9 0.0 26 80 1036 1094 1017 1135 0.69 Adenylylsulphate kinase +APS_kinase PF01583.13 157 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.055 12.8 0.5 3 5 0.69 2.7e+02 0.8 0.0 3 27 1987 2011 1985 2017 0.81 Adenylylsulphate kinase +APS_kinase PF01583.13 157 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.055 12.8 0.5 4 5 1.8 6.8e+02 -0.5 0.0 7 30 2390 2413 2387 2421 0.85 Adenylylsulphate kinase +APS_kinase PF01583.13 157 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.055 12.8 0.5 5 5 0.085 32 3.8 0.0 6 30 2662 2686 2658 2706 0.86 Adenylylsulphate kinase +PRK PF00485.11 194 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.064 12.4 0.1 1 4 8.3 3.2e+03 -2.9 0.0 2 35 841 874 840 891 0.73 Phosphoribulokinase / Uridine kinase family +PRK PF00485.11 194 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.064 12.4 0.1 2 4 0.54 2.1e+02 1.0 0.0 6 33 1993 2028 1990 2055 0.76 Phosphoribulokinase / Uridine kinase family +PRK PF00485.11 194 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.064 12.4 0.1 3 4 1.1 4.1e+02 0.0 0.0 6 31 2392 2417 2391 2431 0.79 Phosphoribulokinase / Uridine kinase family +PRK PF00485.11 194 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.064 12.4 0.1 4 4 0.025 9.7 5.3 0.0 5 39 2664 2698 2662 2721 0.80 Phosphoribulokinase / Uridine kinase family +TIP49 PF06068.6 398 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.098 11.0 0.1 1 4 0.025 9.8 4.4 0.0 51 74 839 862 831 868 0.86 TIP49 C-terminus +TIP49 PF06068.6 398 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.098 11.0 0.1 2 4 0.13 51 2.0 0.0 25 89 1954 2031 1937 2045 0.65 TIP49 C-terminus +TIP49 PF06068.6 398 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.098 11.0 0.1 3 4 8.6 3.3e+03 -3.9 0.0 54 67 2389 2402 2388 2405 0.90 TIP49 C-terminus +TIP49 PF06068.6 398 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.098 11.0 0.1 4 4 1.9 7.2e+02 -1.7 0.0 53 70 2661 2678 2653 2685 0.79 TIP49 C-terminus +zf-NF-X1 PF01422.10 20 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.14 11.8 12.5 1 1 0.001 0.4 10.3 8.6 1 20 1517 1537 1517 1537 0.97 NF-X1 type zinc finger +SKI PF01202.15 158 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.22 11.0 0.9 1 4 8.3 3.2e+03 -2.5 0.0 88 110 840 862 824 885 0.60 Shikimate kinase +SKI PF01202.15 158 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.22 11.0 0.9 2 4 0.61 2.3e+02 1.2 0.0 1 16 1995 2010 1995 2014 0.88 Shikimate kinase +SKI PF01202.15 158 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.22 11.0 0.9 3 4 0.42 1.6e+02 1.7 0.0 1 17 2394 2410 2394 2412 0.87 Shikimate kinase +SKI PF01202.15 158 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.22 11.0 0.9 4 4 0.22 86 2.6 0.0 1 16 2667 2682 2667 2691 0.91 Shikimate kinase +DUF2934 PF11154.1 40 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.32 10.0 1.6 1 2 0.065 25 4.0 0.5 6 25 1923 1942 1918 1944 0.85 Protein of unknown function (DUF2934) +DUF2934 PF11154.1 40 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.32 10.0 1.6 2 2 0.054 21 4.2 0.0 3 32 2820 2849 2818 2849 0.93 Protein of unknown function (DUF2934) +DUF3373 PF11853.1 489 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.45 8.6 2.9 1 1 0.0021 0.8 7.8 2.0 15 69 1592 1643 1584 1688 0.78 Protein of unknown function (DUF3373) +DUF3340 PF11818.1 143 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.95 9.1 8.8 1 2 0.0005 0.19 11.3 0.6 65 136 1042 1122 1030 1129 0.76 C-terminal domain of tail specific protease (DUF3340) +DUF3340 PF11818.1 143 jgi|Monbr1|5003|fgenesh1_pg.scaffold_2000319 - 3072 0.95 9.1 8.8 2 2 1 4e+02 0.6 1.2 24 96 1604 1644 1594 1690 0.58 C-terminal domain of tail specific protease (DUF3340) +DUF1510 PF07423.4 217 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 0.071 12.1 4.2 1 1 6.6e-05 0.11 11.5 2.9 55 114 95 152 12 174 0.57 Protein of unknown function (DUF1510) +Serinc PF03348.8 429 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 0.55 8.5 2.4 1 1 0.00046 0.79 8.0 1.7 322 351 97 137 9 153 0.63 Serine incorporator (Serinc) +DUF1742 PF08432.3 182 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 0.62 9.7 12.1 1 1 0.00059 1 9.0 8.4 40 157 51 170 49 201 0.53 Fungal protein of unknown function (DUF1742) +Nha1_C PF08619.3 433 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 1 8.2 11.8 1 1 0.00087 1.5 7.7 8.1 317 398 52 155 17 216 0.50 Alkali metal cation/H+ antiporter Nha1 C terminus +SprA-related PF12118.1 295 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 1.2 8.1 32.6 1 1 0.0014 2.3 7.1 22.6 90 147 91 148 61 157 0.50 SprA-related family +Med15 PF09606.3 799 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 1.6 6.5 52.0 1 1 0.0014 2.4 5.9 36.0 203 310 94 208 46 276 0.51 ARC105 or Med15 subunit of Mediator complex non-fungal +Band_3_cyto PF07565.6 257 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 1.9 7.5 10.6 1 2 0.005 8.6 5.4 7.7 100 155 93 158 75 175 0.51 Band 3 cytoplasmic domain +Band_3_cyto PF07565.6 257 jgi|Monbr1|5011|fgenesh1_pg.scaffold_2000327 - 791 1.9 7.5 10.6 2 2 0.85 1.5e+03 -1.9 0.0 225 250 557 582 553 588 0.83 Band 3 cytoplasmic domain +Adeno_E1B_55K_N PF04623.5 71 jgi|Monbr1|5019|fgenesh1_pg.scaffold_2000335 - 443 0.032 14.4 0.2 1 3 2.7e-06 0.032 14.4 0.2 25 67 53 98 39 101 0.73 Adenovirus E1B protein N-terminus +Adeno_E1B_55K_N PF04623.5 71 jgi|Monbr1|5019|fgenesh1_pg.scaffold_2000335 - 443 0.032 14.4 0.2 2 3 0.5 6e+03 -2.5 0.4 38 49 234 245 221 252 0.72 Adenovirus E1B protein N-terminus +Adeno_E1B_55K_N PF04623.5 71 jgi|Monbr1|5019|fgenesh1_pg.scaffold_2000335 - 443 0.032 14.4 0.2 3 3 1 1.2e+04 -3.5 0.6 28 44 393 409 388 419 0.54 Adenovirus E1B protein N-terminus +ParcG PF10274.2 183 jgi|Monbr1|5024|fgenesh1_pg.scaffold_2000340 - 233 2.6e-76 255.3 0.0 1 1 3.2e-79 3.8e-75 251.5 0.0 1 183 17 229 17 229 0.99 Parkin co-regulated protein +Methyltransf_16 PF10294.2 169 jgi|Monbr1|5028|fgenesh1_pg.scaffold_2000344 - 299 1.4e-16 60.1 0.0 1 2 5.8e-16 1.7e-12 46.7 0.1 16 90 72 141 35 153 0.90 Putative methyltransferase +Methyltransf_16 PF10294.2 169 jgi|Monbr1|5028|fgenesh1_pg.scaffold_2000344 - 299 1.4e-16 60.1 0.0 2 2 4.6e-05 0.14 11.3 0.0 96 164 177 256 169 261 0.78 Putative methyltransferase +PrmA PF06325.6 295 jgi|Monbr1|5028|fgenesh1_pg.scaffold_2000344 - 299 0.0044 15.8 0.0 1 1 3.1e-06 0.0092 14.8 0.0 161 208 97 143 84 154 0.86 Ribosomal protein L11 methyltransferase (PrmA) +tRNA_U5-meth_tr PF05958.4 352 jgi|Monbr1|5028|fgenesh1_pg.scaffold_2000344 - 299 0.016 13.5 0.0 1 1 8.1e-06 0.024 13.0 0.0 138 242 36 143 22 147 0.81 tRNA (Uracil-5-)-methyltransferase +MTS PF05175.7 170 jgi|Monbr1|5028|fgenesh1_pg.scaffold_2000344 - 299 0.022 13.8 0.0 1 1 1.2e-05 0.036 13.1 0.0 31 76 97 140 76 153 0.71 Methyltransferase small domain +C2 PF00168.23 85 jgi|Monbr1|5034|fgenesh1_pg.scaffold_2000350 - 469 9.6e-17 60.3 0.0 1 1 2.2e-20 2.6e-16 58.9 0.0 1 78 48 128 48 135 0.89 C2 domain +PB1 PF00564.17 84 jgi|Monbr1|5046|fgenesh1_pg.scaffold_2000362 - 289 9.6e-06 24.8 0.0 1 1 3.4e-09 1.4e-05 24.3 0.0 1 54 8 65 8 90 0.87 PB1 domain +DUF605 PF04652.9 383 jgi|Monbr1|5046|fgenesh1_pg.scaffold_2000362 - 289 0.0047 16.0 29.8 1 1 1.4e-06 0.0056 15.7 20.6 174 327 113 267 45 285 0.48 Vta1 like +PAT1 PF09770.2 805 jgi|Monbr1|5046|fgenesh1_pg.scaffold_2000362 - 289 0.065 11.1 20.8 1 1 2.1e-05 0.084 10.7 14.4 86 230 120 267 99 286 0.49 Topoisomerase II-associated protein PAT1 +NUDIX PF00293.21 135 jgi|Monbr1|5048|fgenesh1_pg.scaffold_2000364 - 207 7.1e-15 54.5 0.1 1 1 8.1e-19 9.7e-15 54.0 0.0 2 119 41 159 40 168 0.84 NUDIX domain +Pkinase_Tyr PF07714.10 259 jgi|Monbr1|5054|fgenesh1_pg.scaffold_2000370 - 1458 2.9e-06 26.2 0.0 1 1 1.3e-09 7.7e-06 24.9 0.0 76 131 395 449 381 478 0.87 Protein tyrosine kinase +Pkinase PF00069.18 260 jgi|Monbr1|5054|fgenesh1_pg.scaffold_2000370 - 1458 0.018 13.8 0.0 1 1 6.3e-06 0.038 12.8 0.0 69 124 391 447 379 465 0.82 Protein kinase domain +DUF2062 PF09835.2 154 jgi|Monbr1|5055|fgenesh1_pg.scaffold_2000371 - 357 0.84 8.9 2.8 1 3 0.17 2.1e+03 -2.1 0.1 43 59 18 34 6 39 0.69 Uncharacterized protein conserved in bacteria (DUF2062) +DUF2062 PF09835.2 154 jgi|Monbr1|5055|fgenesh1_pg.scaffold_2000371 - 357 0.84 8.9 2.8 2 3 0.14 1.6e+03 -1.8 0.0 108 129 69 90 43 99 0.59 Uncharacterized protein conserved in bacteria (DUF2062) +DUF2062 PF09835.2 154 jgi|Monbr1|5055|fgenesh1_pg.scaffold_2000371 - 357 0.84 8.9 2.8 3 3 0.00013 1.5 8.1 0.0 16 53 315 352 301 355 0.82 Uncharacterized protein conserved in bacteria (DUF2062) +WW PF00397.19 30 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 2.8e-07 29.9 2.1 1 1 3.9e-10 5.7e-07 28.9 1.4 4 30 1234 1261 1234 1261 0.97 WW domain +ATP-synt_DE PF00401.13 48 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.02 14.4 1.1 1 3 0.58 8.7e+02 -0.4 0.0 3 16 406 419 405 426 0.75 ATP synthase, Delta/Epsilon chain, long alpha-helix domain +ATP-synt_DE PF00401.13 48 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.02 14.4 1.1 2 3 0.00013 0.19 11.3 0.0 3 19 465 481 463 486 0.90 ATP synthase, Delta/Epsilon chain, long alpha-helix domain +ATP-synt_DE PF00401.13 48 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.02 14.4 1.1 3 3 2 3e+03 -2.1 0.0 9 33 556 580 556 581 0.83 ATP synthase, Delta/Epsilon chain, long alpha-helix domain +Herpes_gE PF02480.9 438 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.021 12.7 0.2 1 1 2.4e-05 0.035 12.0 0.1 301 385 922 1005 920 1037 0.72 Alphaherpesvirus glycoprotein E +Sigma54_CBD PF04963.6 195 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.072 12.2 0.1 1 1 0.00012 0.17 10.9 0.0 105 152 497 544 488 551 0.88 Sigma-54 factor, core binding domain +DUF2029 PF09594.3 241 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.51 9.4 2.3 1 2 2.6 3.9e+03 -3.3 0.0 144 191 279 328 271 369 0.58 Protein of unknown function (DUF2029) +DUF2029 PF09594.3 241 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.51 9.4 2.3 2 2 0.00039 0.58 9.2 0.5 173 227 951 1007 938 1011 0.65 Protein of unknown function (DUF2029) +VSP PF03302.6 397 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 0.56 8.4 3.3 1 1 0.00065 0.97 7.6 2.3 358 380 963 985 946 995 0.77 Giardia variant-specific surface protein +DUF2336 PF10098.2 262 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 1.5 7.6 5.9 1 3 0.00046 0.69 8.7 0.5 193 251 501 556 494 567 0.79 Uncharacterized protein conserved in bacteria (DUF2336) +DUF2336 PF10098.2 262 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 1.5 7.6 5.9 2 3 0.28 4.2e+02 -0.4 0.0 194 229 561 596 553 608 0.80 Uncharacterized protein conserved in bacteria (DUF2336) +DUF2336 PF10098.2 262 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 1.5 7.6 5.9 3 3 1.3 1.9e+03 -2.5 0.2 174 230 623 679 618 705 0.60 Uncharacterized protein conserved in bacteria (DUF2336) +MGC-24 PF05283.4 186 jgi|Monbr1|5062|fgenesh1_pg.scaffold_2000378 - 1268 1.8 8.0 4.3 1 1 0.0033 4.9 6.6 3.0 109 157 1006 1057 993 1059 0.73 Multi-glycosylated core protein 24 (MGC-24) +Sec39 PF08314.4 713 jgi|Monbr1|5066|fgenesh1_pg.scaffold_2000382 - 1942 0.025 12.1 0.5 1 3 0.00051 3 5.3 0.0 2 55 630 681 629 712 0.83 Secretory pathway protein Sec39 +Sec39 PF08314.4 713 jgi|Monbr1|5066|fgenesh1_pg.scaffold_2000382 - 1942 0.025 12.1 0.5 2 3 0.078 4.6e+02 -2.0 0.0 345 441 919 1006 870 1013 0.75 Secretory pathway protein Sec39 +Sec39 PF08314.4 713 jgi|Monbr1|5066|fgenesh1_pg.scaffold_2000382 - 1942 0.025 12.1 0.5 3 3 0.002 12 3.3 0.0 459 530 1096 1162 1086 1186 0.85 Secretory pathway protein Sec39 +DUF445 PF04286.5 367 jgi|Monbr1|5066|fgenesh1_pg.scaffold_2000382 - 1942 0.32 10.1 2.2 1 2 1.2 7.1e+03 -4.2 0.1 225 263 1083 1121 1077 1135 0.72 Protein of unknown function (DUF445) +DUF445 PF04286.5 367 jgi|Monbr1|5066|fgenesh1_pg.scaffold_2000382 - 1942 0.32 10.1 2.2 2 2 3.3e-05 0.2 10.8 0.1 118 245 1405 1527 1312 1639 0.76 Protein of unknown function (DUF445) +Smac_DIABLO PF09057.3 234 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.0074 15.1 1.4 1 1 3.9e-06 0.012 14.4 1.0 146 203 21 78 15 95 0.82 Second Mitochondria-derived Activator of Caspases +Nucleopor_Nup85 PF07575.6 573 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.0097 13.8 0.2 1 1 4.8e-06 0.014 13.3 0.2 157 215 17 74 14 82 0.82 Nup85 Nucleoporin +TPR_1 PF00515.21 34 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.05 12.9 4.1 1 5 0.0092 27 4.2 0.0 13 29 20 36 19 41 0.87 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.05 12.9 4.1 2 5 0.28 8.3e+02 -0.5 0.0 3 19 50 66 48 79 0.81 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.05 12.9 4.1 3 5 0.95 2.8e+03 -2.2 0.0 1 14 88 101 88 101 0.85 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.05 12.9 4.1 4 5 0.094 2.8e+02 1.0 0.0 20 30 150 160 147 161 0.91 Tetratricopeptide repeat +TPR_1 PF00515.21 34 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 0.05 12.9 4.1 5 5 0.0051 15 5.0 0.1 2 25 172 195 171 196 0.94 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 1 9.6 8.8 1 4 0.0039 12 6.4 0.1 13 26 20 33 19 33 0.95 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 1 9.6 8.8 2 4 0.99 2.9e+03 -1.1 0.0 13 26 60 73 55 73 0.80 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 1 9.6 8.8 3 4 0.11 3.2e+02 1.9 0.4 3 14 156 167 155 167 0.85 Tetratricopeptide repeat +TPR_4 PF07721.7 26 jgi|Monbr1|5067|fgenesh1_pg.scaffold_2000383 - 334 1 9.6 8.8 4 4 0.075 2.2e+02 2.4 0.1 3 21 173 191 172 195 0.87 Tetratricopeptide repeat +YbaK PF04073.8 123 jgi|Monbr1|5084|fgenesh1_pg.scaffold_2000400 - 194 1.6e-10 40.5 0.0 1 1 2e-14 2.4e-10 40.0 0.0 30 122 74 172 62 173 0.87 YbaK / prolyl-tRNA synthetases associated domain +FAT PF02259.16 351 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-82 276.8 0.2 1 2 1.1e-85 1.8e-82 276.8 0.2 1 351 972 1310 972 1310 0.93 FAT domain +FAT PF02259.16 351 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-82 276.8 0.2 2 2 0.65 1.1e+03 -2.1 0.1 260 306 1488 1531 1483 1541 0.84 FAT domain +PI3_PI4_kinase PF00454.20 235 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.9e-58 197.3 0.2 1 1 2.1e-61 3.6e-58 196.5 0.1 2 233 1588 1835 1587 1836 0.97 Phosphatidylinositol 3- and 4-kinase +Rapamycin_bind PF08771.4 100 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 2.2e-28 97.9 1.7 1 1 3.9e-31 6.6e-28 96.4 1.2 1 99 1419 1518 1419 1519 0.97 Rapamycin binding domain +DUF3385 PF11865.1 160 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 2.3e-24 85.7 1.1 1 4 2.5e-26 4.3e-23 81.6 0.0 1 158 370 540 370 542 0.83 Domain of unknown function (DUF3385) +DUF3385 PF11865.1 160 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 2.3e-24 85.7 1.1 2 4 0.86 1.5e+03 -1.4 0.0 9 33 580 603 574 614 0.64 Domain of unknown function (DUF3385) +DUF3385 PF11865.1 160 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 2.3e-24 85.7 1.1 3 4 0.6 1e+03 -0.9 0.0 91 138 1305 1349 1293 1366 0.66 Domain of unknown function (DUF3385) +DUF3385 PF11865.1 160 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 2.3e-24 85.7 1.1 4 4 3.7 6.3e+03 -3.4 0.0 5 27 1506 1528 1503 1530 0.82 Domain of unknown function (DUF3385) +FATC PF02260.13 33 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.3e-14 52.9 0.1 1 1 2.4e-17 4.1e-14 51.3 0.0 3 33 1911 1941 1909 1941 0.97 FATC domain +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 1 7 0.00058 0.98 9.3 0.1 5 28 130 153 127 153 0.89 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 2 7 0.098 1.7e+02 2.4 0.0 2 30 213 241 213 242 0.92 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 3 7 0.0088 15 5.6 0.0 1 28 295 322 295 325 0.94 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 4 7 0.004 6.9 6.7 0.0 1 29 336 365 336 367 0.94 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 5 7 4.2 7.2e+03 -2.7 0.0 13 27 393 407 392 409 0.85 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 6 7 0.23 3.9e+02 1.2 0.0 1 27 511 537 511 541 0.80 HEAT repeat +HEAT PF02985.15 31 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 1.8e-06 27.2 7.9 7 7 5.2 8.9e+03 -3.0 0.0 15 25 639 649 639 652 0.83 HEAT repeat +Arm PF00514.16 41 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 0.0048 16.3 0.7 1 4 0.38 6.4e+02 0.1 0.0 20 33 133 146 129 148 0.87 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 0.0048 16.3 0.7 2 4 1.5 2.6e+03 -1.9 0.0 8 40 207 239 205 240 0.83 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 0.0048 16.3 0.7 3 4 0.00045 0.76 9.3 0.0 13 40 295 322 289 323 0.90 Armadillo/beta-catenin-like repeat +Arm PF00514.16 41 jgi|Monbr1|5087|fgenesh1_pg.scaffold_2000403 - 1941 0.0048 16.3 0.7 4 4 1.2 2.1e+03 -1.6 0.0 15 37 378 405 378 407 0.87 Armadillo/beta-catenin-like repeat +MIF4G_like PF09088.4 191 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.035 13.2 0.2 1 2 0.93 3.7e+03 -3.2 0.0 165 181 67 83 58 90 0.70 MIF4G like +MIF4G_like PF09088.4 191 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.035 13.2 0.2 2 2 2.2e-05 0.085 11.9 0.0 94 128 185 219 153 224 0.85 MIF4G like +DUF3437 PF11919.1 90 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.045 13.1 0.6 1 3 0.46 1.8e+03 -1.7 0.0 27 41 70 84 58 89 0.79 Domain of unknown function (DUF3437) +DUF3437 PF11919.1 90 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.045 13.1 0.6 2 3 0.00014 0.54 9.6 0.1 2 50 176 225 175 239 0.73 Domain of unknown function (DUF3437) +DUF3437 PF11919.1 90 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.045 13.1 0.6 3 3 0.13 5.3e+02 0.0 0.0 3 17 257 271 255 276 0.87 Domain of unknown function (DUF3437) +CLASP_N PF12348.1 227 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.12 11.4 0.1 1 2 0.078 3.1e+02 0.2 0.0 73 109 51 88 32 110 0.69 CLASP N terminal +CLASP_N PF12348.1 227 jgi|Monbr1|5088|fgenesh1_pg.scaffold_2000404 - 419 0.12 11.4 0.1 2 2 0.00024 0.96 8.4 0.0 71 185 181 295 153 296 0.74 CLASP N terminal +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 1 7 1.6e-07 0.00048 19.3 0.1 3 21 99 117 97 140 0.80 FG-GAP repeat +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 2 7 5.3e-05 0.16 11.3 0.0 5 28 151 171 148 176 0.86 FG-GAP repeat +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 3 7 1.3e-06 0.0039 16.4 0.6 2 20 198 216 197 232 0.83 FG-GAP repeat +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 4 7 3e-06 0.009 15.3 0.7 5 28 251 272 249 283 0.80 FG-GAP repeat +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 5 7 1.9e-06 0.0056 15.9 0.2 4 20 300 316 297 336 0.84 FG-GAP repeat +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 6 7 3.8e-06 0.011 15.0 0.2 3 20 349 366 347 388 0.84 FG-GAP repeat +FG-GAP PF01839.16 33 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 2.1e-22 77.7 38.3 7 7 0.0014 4.2 6.8 1.8 2 20 398 416 397 432 0.85 FG-GAP repeat +DUF943 PF06092.5 157 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 6.8e-05 21.8 3.6 1 5 0.12 3.7e+02 -0.0 0.1 55 77 122 145 119 172 0.69 Enterobacterial putative membrane protein (DUF943) +DUF943 PF06092.5 157 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 6.8e-05 21.8 3.6 2 5 0.00023 0.69 8.8 0.0 51 98 218 266 200 273 0.75 Enterobacterial putative membrane protein (DUF943) +DUF943 PF06092.5 157 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 6.8e-05 21.8 3.6 3 5 0.016 49 2.8 0.0 55 94 272 312 266 319 0.75 Enterobacterial putative membrane protein (DUF943) +DUF943 PF06092.5 157 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 6.8e-05 21.8 3.6 4 5 0.088 2.6e+02 0.5 0.0 55 90 322 357 316 371 0.79 Enterobacterial putative membrane protein (DUF943) +DUF943 PF06092.5 157 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 6.8e-05 21.8 3.6 5 5 0.0023 6.8 5.6 0.0 55 89 372 406 366 413 0.87 Enterobacterial putative membrane protein (DUF943) +TcdB_toxin_midN PF12256.1 174 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.15 11.2 21.6 1 6 0.0012 3.6 6.7 0.2 24 44 99 119 83 133 0.74 Insecticide toxin TcdB middle/N-terminal region +TcdB_toxin_midN PF12256.1 174 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.15 11.2 21.6 2 6 0.027 80 2.3 0.2 5 41 133 166 129 182 0.69 Insecticide toxin TcdB middle/N-terminal region +TcdB_toxin_midN PF12256.1 174 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.15 11.2 21.6 3 6 0.024 72 2.4 0.1 17 42 192 218 178 233 0.70 Insecticide toxin TcdB middle/N-terminal region +TcdB_toxin_midN PF12256.1 174 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.15 11.2 21.6 4 6 0.0042 12 4.9 0.1 23 46 247 271 227 290 0.70 Insecticide toxin TcdB middle/N-terminal region +TcdB_toxin_midN PF12256.1 174 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.15 11.2 21.6 5 6 0.0037 11 5.1 0.2 23 41 296 316 279 328 0.72 Insecticide toxin TcdB middle/N-terminal region +TcdB_toxin_midN PF12256.1 174 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.15 11.2 21.6 6 6 0.037 1.1e+02 1.8 0.1 6 41 334 366 328 393 0.75 Insecticide toxin TcdB middle/N-terminal region +ENOD93 PF03386.7 79 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.65 9.4 6.4 1 4 0.043 1.3e+02 2.0 0.1 39 65 224 251 214 256 0.79 Early nodulin 93 ENOD93 protein +ENOD93 PF03386.7 79 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.65 9.4 6.4 2 4 2.5 7.4e+03 -3.6 0.0 40 57 275 294 274 297 0.53 Early nodulin 93 ENOD93 protein +ENOD93 PF03386.7 79 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.65 9.4 6.4 3 4 0.0012 3.5 7.0 0.0 39 67 324 353 322 356 0.86 Early nodulin 93 ENOD93 protein +ENOD93 PF03386.7 79 jgi|Monbr1|5094|fgenesh1_pg.scaffold_2000410 - 440 0.65 9.4 6.4 4 4 0.067 2e+02 1.4 0.0 41 67 376 403 373 406 0.74 Early nodulin 93 ENOD93 protein +Lectin_C PF00059.14 108 jgi|Monbr1|5101|fgenesh1_pg.scaffold_2000417 - 121 0.0065 16.4 0.0 1 1 7.3e-07 0.0087 16.0 0.0 3 47 51 96 49 115 0.89 Lectin C-type domain +Recep_L_domain PF01030.17 112 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 2.4e-05 23.9 1.1 1 2 0.021 35 4.0 0.0 61 100 16 52 3 57 0.60 Receptor L domain +Recep_L_domain PF01030.17 112 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 2.4e-05 23.9 1.1 2 2 3.5e-05 0.06 13.0 0.1 20 75 212 259 123 301 0.71 Receptor L domain +Mucin PF01456.10 143 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 0.19 11.2 19.3 1 1 0.00025 0.42 10.0 13.4 46 74 66 94 43 115 0.54 Mucin-like glycoprotein +Sporozoite_P67 PF05642.4 727 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 0.38 8.2 5.7 1 1 0.00027 0.46 7.9 3.9 269 300 59 90 11 113 0.59 Sporozoite P67 surface antigen +Late_protein_L2 PF00513.11 467 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 0.42 9.0 2.1 1 1 0.00032 0.55 8.7 1.4 127 175 65 112 53 162 0.69 Late Protein L2 +SSP160 PF06933.4 756 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 0.57 7.7 16.4 1 1 0.00056 0.95 7.0 11.3 671 706 58 97 31 118 0.58 Special lobe-specific silk protein SSP160 +SoxE PF06525.4 195 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 1.2 8.0 8.9 1 1 0.0013 2.2 7.2 6.1 11 48 60 97 53 111 0.75 Sulfocyanin (SoxE) +DUF3446 PF11928.1 84 jgi|Monbr1|5103|fgenesh1_pg.scaffold_2000419 - 316 1.8 8.5 5.2 1 1 0.0027 4.6 7.2 3.6 26 63 58 93 40 110 0.61 Domain of unknown function (DUF3446) +CAP_GLY PF01302.18 69 jgi|Monbr1|5106|fgenesh1_pg.scaffold_2000422 - 514 7.5e-05 22.0 0.6 1 2 2.3e-07 0.0013 18.0 0.2 7 48 13 53 7 58 0.85 CAP-Gly domain +CAP_GLY PF01302.18 69 jgi|Monbr1|5106|fgenesh1_pg.scaffold_2000422 - 514 7.5e-05 22.0 0.6 2 2 0.00037 2.2 7.7 0.0 11 34 46 68 43 80 0.84 CAP-Gly domain +Troponin PF00992.13 132 jgi|Monbr1|5106|fgenesh1_pg.scaffold_2000422 - 514 0.17 11.6 7.9 1 1 5.7e-05 0.34 10.6 5.5 35 124 395 488 392 492 0.83 Troponin +Cupin_4 PF08007.5 319 jgi|Monbr1|5112|fgenesh1_pg.scaffold_2000428 - 476 1.3e-16 60.4 0.4 1 1 5.6e-20 6.7e-16 58.0 0.3 112 208 162 280 148 296 0.74 Cupin superfamily protein +Peroxin-3 PF04882.5 431 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.01 14.3 1.0 1 1 1.1e-05 0.011 14.1 0.7 68 113 66 111 51 114 0.78 Peroxin-3 +RNA_polI_A14 PF08203.4 160 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.013 14.8 7.6 1 1 1.5e-05 0.016 14.6 5.2 104 152 74 113 45 114 0.50 Yeast RNA polymerase I subunit RPA14 +LcrG PF07216.5 93 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.06 13.0 0.6 1 1 7.1e-05 0.077 12.7 0.4 36 84 56 110 36 113 0.71 LcrG protein +RRS1 PF04939.5 164 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.18 10.9 7.7 1 1 0.00022 0.24 10.5 5.4 123 164 73 113 66 113 0.85 Ribosome biogenesis regulatory protein (RRS1) +UPF0564 PF10595.2 356 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.34 9.4 2.3 1 1 0.00029 0.31 9.5 1.6 278 311 84 112 24 114 0.54 Uncharacterised protein family UPF0564 +DUF3381 PF11861.1 159 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.43 9.7 7.9 1 1 0.00043 0.47 9.6 5.5 109 149 75 112 50 114 0.50 Domain of unknown function (DUF3381) +RNA_polI_A34 PF08208.4 202 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.44 9.8 13.3 1 1 0.00046 0.5 9.6 9.2 150 181 82 112 56 114 0.53 DNA-directed RNA polymerase I subunit RPA34.5 +RNase_H2-Ydr279 PF09468.3 306 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.7 8.7 5.4 1 1 0.00073 0.79 8.5 3.7 233 283 71 112 41 114 0.50 Ydr279p protein family (RNase H2 complex component) +Peptidase_S49_N PF08496.3 155 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 0.76 9.2 7.6 1 1 0.00078 0.84 9.0 5.3 52 88 75 112 51 114 0.71 Peptidase family S49 N-terminal +DUF1682 PF07946.7 321 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 1.7 7.1 6.8 1 1 0.0016 1.7 7.0 4.7 264 296 82 113 46 114 0.69 Protein of unknown function (DUF1682) +RR_TM4-6 PF06459.5 274 jgi|Monbr1|5116|fgenesh1_pg.scaffold_2000432 - 114 1.9 8.0 4.7 1 1 0.0017 1.8 8.0 3.2 94 143 62 110 30 114 0.48 Ryanodine Receptor TM 4-6 +DEAD PF00270.22 167 jgi|Monbr1|5117|fgenesh1_pg.scaffold_2000433 - 591 2.3e-42 144.0 0.0 1 1 1.8e-45 4.4e-42 143.0 0.0 2 162 24 192 23 197 0.92 DEAD/DEAH box helicase +GUCT PF08152.5 97 jgi|Monbr1|5117|fgenesh1_pg.scaffold_2000433 - 591 5e-27 93.4 0.0 1 1 6.3e-30 1.5e-26 91.9 0.0 1 96 430 525 430 526 0.99 GUCT (NUC152) domain +Helicase_C PF00271.24 78 jgi|Monbr1|5117|fgenesh1_pg.scaffold_2000433 - 591 5.4e-26 89.9 0.0 1 1 5.5e-29 1.3e-25 88.6 0.0 9 78 273 342 267 342 0.96 Helicase conserved C-terminal domain +ResIII PF04851.8 184 jgi|Monbr1|5117|fgenesh1_pg.scaffold_2000433 - 591 0.016 14.7 0.0 1 1 3e-05 0.072 12.6 0.0 26 74 37 96 20 191 0.63 Type III restriction enzyme, res subunit +DUF1859 PF08948.3 126 jgi|Monbr1|5117|fgenesh1_pg.scaffold_2000433 - 591 0.046 13.1 0.0 1 1 3.7e-05 0.089 12.2 0.0 10 104 100 196 93 203 0.78 Domain of unknown function (DUF1859) +PKD_channel PF08016.5 426 jgi|Monbr1|5126|fgenesh1_pg.scaffold_2000442 - 786 3.7e-06 25.3 4.9 1 1 1.3e-09 7.5e-06 24.3 3.4 299 425 478 611 471 612 0.88 Polycystin cation channel +Mst1_SARAH PF11629.1 49 jgi|Monbr1|5126|fgenesh1_pg.scaffold_2000442 - 786 0.11 11.9 0.2 1 1 6.8e-05 0.41 10.2 0.1 9 32 741 764 738 766 0.93 C terminal SARAH domain of Mst1 +PC4 PF02229.9 83 jgi|Monbr1|5135|fgenesh1_pg.scaffold_2000451 - 182 1.5e-16 59.5 0.1 1 2 2.3e-14 1.4e-10 40.4 0.1 14 66 58 113 42 141 0.82 Transcriptional Coactivator p15 (PC4) +PC4 PF02229.9 83 jgi|Monbr1|5135|fgenesh1_pg.scaffold_2000451 - 182 1.5e-16 59.5 0.1 2 2 6.2e-07 0.0037 16.6 0.0 58 83 151 176 140 176 0.88 Transcriptional Coactivator p15 (PC4) +Mt_ATP-synt_D PF05873.5 161 jgi|Monbr1|5135|fgenesh1_pg.scaffold_2000451 - 182 0.081 12.2 0.4 1 3 0.00034 2.1 7.6 0.0 30 74 26 71 8 83 0.78 ATP synthase D chain, mitochondrial (ATP5H) +Mt_ATP-synt_D PF05873.5 161 jgi|Monbr1|5135|fgenesh1_pg.scaffold_2000451 - 182 0.081 12.2 0.4 2 3 0.026 1.6e+02 1.5 0.0 18 46 118 146 113 153 0.86 ATP synthase D chain, mitochondrial (ATP5H) +Mt_ATP-synt_D PF05873.5 161 jgi|Monbr1|5135|fgenesh1_pg.scaffold_2000451 - 182 0.081 12.2 0.4 3 3 0.17 1e+03 -1.1 0.0 11 26 161 176 150 180 0.80 ATP synthase D chain, mitochondrial (ATP5H) +Rap_GAP PF02145.8 188 jgi|Monbr1|5147|fgenesh1_pg.scaffold_2000463 - 823 2.1e-56 189.9 0.0 1 1 7.9e-60 4.7e-56 188.8 0.0 1 188 227 414 227 414 0.97 Rap/ran-GAP +CNH PF00780.15 275 jgi|Monbr1|5147|fgenesh1_pg.scaffold_2000463 - 823 1.4e-24 86.6 0.0 1 1 8.3e-28 4.9e-24 84.8 0.0 2 261 495 777 494 787 0.84 CNH domain +PH PF00169.22 104 jgi|Monbr1|5148|fgenesh1_pg.scaffold_2000464 - 266 2.3e-25 88.5 0.0 1 2 1.4e-11 1.7e-07 31.0 0.0 16 103 6 100 3 101 0.92 PH domain +PH PF00169.22 104 jgi|Monbr1|5148|fgenesh1_pg.scaffold_2000464 - 266 2.3e-25 88.5 0.0 2 2 3.6e-19 4.3e-15 55.5 0.0 13 103 158 240 148 241 0.94 PH domain +PARP PF00644.13 205 jgi|Monbr1|5151|fgenesh1_pg.scaffold_2000467 - 399 3.7e-05 22.8 0.2 1 1 5.2e-09 6.1e-05 22.1 0.1 60 114 303 360 269 386 0.76 Poly(ADP-ribose) polymerase catalytic domain +MFS_1 PF07690.9 353 jgi|Monbr1|5154|fgenesh1_pg.scaffold_2000470 - 1270 0.15 10.4 3.7 1 1 5.2e-05 0.31 9.4 2.6 245 333 921 1007 854 1021 0.61 Major Facilitator Superfamily +DUF2339 PF10101.2 745 jgi|Monbr1|5154|fgenesh1_pg.scaffold_2000470 - 1270 0.62 7.9 6.2 1 1 0.00018 1.1 7.1 4.3 357 455 928 1023 895 1046 0.65 Predicted membrane protein (DUF2339) +fn3 PF00041.14 85 jgi|Monbr1|5155|fgenesh1_pg.scaffold_2000471 - 397 0.022 14.5 0.1 1 2 0.32 3.8e+03 -2.2 0.0 70 81 157 168 147 172 0.68 Fibronectin type III domain +fn3 PF00041.14 85 jgi|Monbr1|5155|fgenesh1_pg.scaffold_2000471 - 397 0.022 14.5 0.1 2 2 7.1e-06 0.085 12.6 0.1 15 82 305 371 300 373 0.78 Fibronectin type III domain +DNA_pol_A PF00476.13 383 jgi|Monbr1|5161|fgenesh1_pg.scaffold_2000477 - 632 4.3e-42 143.7 0.0 1 2 7.9e-12 9.4e-08 30.7 0.0 13 118 316 421 307 424 0.85 DNA polymerase family A +DNA_pol_A PF00476.13 383 jgi|Monbr1|5161|fgenesh1_pg.scaffold_2000477 - 632 4.3e-42 143.7 0.0 2 2 2.6e-36 3.1e-32 111.3 0.0 210 342 424 558 420 562 0.97 DNA polymerase family A +Esterase PF00756.13 252 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 3.3e-06 26.3 0.2 1 2 0.59 1.4e+03 -1.9 0.0 19 44 212 236 202 250 0.76 Putative esterase +Esterase PF00756.13 252 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 3.3e-06 26.3 0.2 2 2 6e-09 1.4e-05 24.2 0.1 113 203 375 479 361 508 0.74 Putative esterase +Peptidase_S9 PF00326.14 213 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.01 14.7 0.4 1 1 7.9e-06 0.019 13.8 0.2 60 212 374 532 363 533 0.74 Prolyl oligopeptidase family +Abhydrolase_2 PF02230.9 216 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.016 14.3 0.0 1 3 0.076 1.8e+02 1.1 0.0 9 35 212 238 205 247 0.79 Phospholipase/Carboxylesterase +Abhydrolase_2 PF02230.9 216 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.016 14.3 0.0 2 3 0.013 31 3.6 0.0 102 142 375 415 354 426 0.85 Phospholipase/Carboxylesterase +Abhydrolase_2 PF02230.9 216 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.016 14.3 0.0 3 3 0.0037 8.8 5.3 0.0 144 199 449 504 425 509 0.88 Phospholipase/Carboxylesterase +Abhydrolase_1 PF00561.13 231 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.089 12.0 0.1 1 1 7.5e-05 0.18 11.0 0.0 42 120 376 493 352 563 0.71 alpha/beta hydrolase fold +Esterase_phd PF10503.2 220 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.26 10.1 1.2 1 2 0.00026 0.61 8.9 0.0 93 187 374 478 359 504 0.73 Esterase PHB depolymerase +Esterase_phd PF10503.2 220 jgi|Monbr1|5167|fgenesh1_pg.scaffold_2000483 - 843 0.26 10.1 1.2 2 2 0.41 9.7e+02 -1.5 0.3 85 159 685 764 679 798 0.64 Esterase PHB depolymerase +DUF3418 PF11898.1 586 jgi|Monbr1|5172|fgenesh1_pg.scaffold_2000488 - 1440 0.0079 14.3 1.9 1 1 3.2e-06 0.013 13.6 1.3 374 512 624 783 595 828 0.85 Domain of unknown function (DUF3418) +DUF885 PF05960.4 542 jgi|Monbr1|5172|fgenesh1_pg.scaffold_2000488 - 1440 0.012 14.4 0.1 1 1 8.1e-06 0.032 13.0 0.0 86 189 507 607 498 643 0.76 Bacterial protein of unknown function (DUF885) +DUF883 PF05957.6 94 jgi|Monbr1|5172|fgenesh1_pg.scaffold_2000488 - 1440 0.2 11.8 8.5 1 4 0.026 1e+02 3.0 0.1 6 68 559 621 554 627 0.78 Bacterial protein of unknown function (DUF883) +DUF883 PF05957.6 94 jgi|Monbr1|5172|fgenesh1_pg.scaffold_2000488 - 1440 0.2 11.8 8.5 2 4 0.91 3.6e+03 -1.9 0.0 12 47 652 687 649 692 0.89 Bacterial protein of unknown function (DUF883) +DUF883 PF05957.6 94 jgi|Monbr1|5172|fgenesh1_pg.scaffold_2000488 - 1440 0.2 11.8 8.5 3 4 0.00015 0.58 10.2 0.4 13 64 699 750 696 759 0.89 Bacterial protein of unknown function (DUF883) +DUF883 PF05957.6 94 jgi|Monbr1|5172|fgenesh1_pg.scaffold_2000488 - 1440 0.2 11.8 8.5 4 4 3 1.2e+04 -4.0 0.1 30 49 1218 1237 1210 1255 0.51 Bacterial protein of unknown function (DUF883) +CH PF00307.24 109 jgi|Monbr1|5194|fgenesh1_pg.scaffold_2000510 - 2144 1.3e-05 24.7 0.8 1 2 2e-08 0.00012 21.7 0.0 3 106 65 204 62 207 0.78 Calponin homology (CH) domain +CH PF00307.24 109 jgi|Monbr1|5194|fgenesh1_pg.scaffold_2000510 - 2144 1.3e-05 24.7 0.8 2 2 0.16 9.3e+02 -0.5 0.1 34 78 443 490 422 521 0.71 Calponin homology (CH) domain +GAS2 PF02187.10 73 jgi|Monbr1|5194|fgenesh1_pg.scaffold_2000510 - 2144 0.02 14.3 0.0 1 1 7.3e-06 0.043 13.2 0.0 28 64 264 300 238 307 0.90 Growth-Arrest-Specific Protein 2 Domain +Sec62 PF03839.9 225 jgi|Monbr1|5197|fgenesh1_pg.scaffold_2000513 - 276 4e-30 104.5 1.2 1 1 9.4e-34 5.6e-30 104.1 0.8 75 219 90 235 68 240 0.82 Translocation protein Sec62 +DEP PF00610.14 74 jgi|Monbr1|5197|fgenesh1_pg.scaffold_2000513 - 276 0.00019 20.8 0.0 1 1 5e-08 0.0003 20.1 0.0 16 55 37 76 16 119 0.82 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) +MIP-T3 PF10243.2 538 jgi|Monbr1|5198|fgenesh1_pg.scaffold_2000514 - 194 1.7 6.6 4.3 1 1 0.00017 2.1 6.3 3.0 238 324 31 122 13 143 0.71 Microtubule-binding protein MIP-T3 +F-box PF00646.26 48 jgi|Monbr1|5203|fgenesh1_pg.scaffold_2000519 - 442 2.7e-08 32.9 0.1 1 1 5.1e-12 6e-08 31.8 0.1 3 42 268 307 267 312 0.94 F-box domain +Trehalase PF01204.11 512 jgi|Monbr1|5220|fgenesh1_pg.scaffold_2000536 - 573 1.3e-09 36.8 0.1 1 2 0.012 74 1.3 0.0 178 215 282 319 279 339 0.85 Trehalase +Trehalase PF01204.11 512 jgi|Monbr1|5220|fgenesh1_pg.scaffold_2000536 - 573 1.3e-09 36.8 0.1 2 2 2.9e-12 1.7e-08 33.1 0.0 321 496 370 547 359 565 0.82 Trehalase +Glyco_hydro_63 PF03200.9 801 jgi|Monbr1|5220|fgenesh1_pg.scaffold_2000536 - 573 1.2e-08 33.0 4.9 1 3 0.00073 4.4 4.7 0.1 390 436 222 268 196 270 0.84 Mannosyl oligosaccharide glucosidase +Glyco_hydro_63 PF03200.9 801 jgi|Monbr1|5220|fgenesh1_pg.scaffold_2000536 - 573 1.2e-08 33.0 4.9 2 3 0.036 2.2e+02 -0.9 0.3 519 611 316 408 277 413 0.75 Mannosyl oligosaccharide glucosidase +Glyco_hydro_63 PF03200.9 801 jgi|Monbr1|5220|fgenesh1_pg.scaffold_2000536 - 573 1.2e-08 33.0 4.9 3 3 2.3e-11 1.4e-07 29.5 0.0 658 775 425 529 416 533 0.84 Mannosyl oligosaccharide glucosidase +Transmemb_17 PF09799.2 109 jgi|Monbr1|5230|fgenesh1_pg.scaffold_2000546 - 174 4.2e-14 52.4 6.0 1 1 5e-18 6e-14 51.9 4.2 37 107 21 91 16 93 0.96 Predicted membrane protein +Ank PF00023.23 33 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 3.7e-22 76.6 6.8 1 5 0.00033 2 8.0 0.0 2 15 300 313 299 329 0.81 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 3.7e-22 76.6 6.8 2 5 4.7e-08 0.00028 20.2 0.0 2 33 400 431 399 431 0.97 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 3.7e-22 76.6 6.8 3 5 3.6e-09 2.1e-05 23.7 0.1 1 32 432 464 432 465 0.94 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 3.7e-22 76.6 6.8 4 5 1.3e-05 0.079 12.5 0.1 2 22 479 499 478 510 0.92 Ankyrin repeat +Ank PF00023.23 33 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 3.7e-22 76.6 6.8 5 5 2.8e-05 0.17 11.4 0.0 7 24 518 535 514 544 0.84 Ankyrin repeat +Cytochrom_B561 PF03188.9 137 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 0.12 11.9 0.4 1 2 0.044 2.6e+02 1.0 0.1 67 109 254 294 245 311 0.59 Eukaryotic cytochrome b561 +Cytochrom_B561 PF03188.9 137 jgi|Monbr1|5245|fgenesh1_pg.scaffold_2000561 - 738 0.12 11.9 0.4 2 2 0.00028 1.7 8.1 0.0 30 86 476 537 467 539 0.79 Eukaryotic cytochrome b561 +DSPc PF00782.13 133 jgi|Monbr1|5247|fgenesh1_pg.scaffold_2000563 - 1047 5.6e-31 106.5 0.0 1 1 3.9e-34 9.3e-31 105.8 0.0 1 131 416 544 416 546 0.97 Dual specificity phosphatase, catalytic domain +SAM_1 PF00536.23 64 jgi|Monbr1|5247|fgenesh1_pg.scaffold_2000563 - 1047 4.4e-12 45.6 0.0 1 1 3.9e-15 9.2e-12 44.6 0.0 3 62 959 1018 957 1020 0.95 SAM domain (Sterile alpha motif) +DEK_C PF08766.4 54 jgi|Monbr1|5247|fgenesh1_pg.scaffold_2000563 - 1047 1.3e-11 43.6 5.1 1 1 1.2e-14 2.9e-11 42.6 3.5 2 50 352 400 351 403 0.95 DEK C terminal domain +SAM_2 PF07647.10 66 jgi|Monbr1|5247|fgenesh1_pg.scaffold_2000563 - 1047 1.6e-09 37.1 0.0 1 1 1.4e-12 3.4e-09 36.1 0.0 3 65 958 1019 956 1020 0.95 SAM domain (Sterile alpha motif) +Y_phosphatase PF00102.20 235 jgi|Monbr1|5247|fgenesh1_pg.scaffold_2000563 - 1047 0.0023 17.0 0.1 1 1 2.2e-06 0.0052 15.8 0.0 144 193 465 509 425 528 0.80 Protein-tyrosine phosphatase +DUF1070 PF06376.5 53 jgi|Monbr1|5264|fgenesh1_pg.scaffold_2000580 - 653 0.13 11.8 0.2 1 1 3.2e-05 0.38 10.3 0.1 4 39 21 58 18 60 0.63 Protein of unknown function (DUF1070) +GCC2_GCC3 PF07699.6 48 jgi|Monbr1|5267|fgenesh1_pg.scaffold_2000583 - 2172 0.37 10.0 15.5 1 2 0.00025 1.5 8.1 3.2 6 35 1413 1440 1403 1442 0.77 GCC2 and GCC3 +GCC2_GCC3 PF07699.6 48 jgi|Monbr1|5267|fgenesh1_pg.scaffold_2000583 - 2172 0.37 10.0 15.5 2 2 0.00026 1.5 8.1 7.6 1 34 1424 1476 1424 1488 0.67 GCC2 and GCC3 +Myc_N PF01056.11 329 jgi|Monbr1|5267|fgenesh1_pg.scaffold_2000583 - 2172 0.55 9.0 9.7 1 2 3.9e-05 0.23 10.2 0.3 132 201 1093 1161 1077 1216 0.75 Myc amino-terminal region +Myc_N PF01056.11 329 jgi|Monbr1|5267|fgenesh1_pg.scaffold_2000583 - 2172 0.55 9.0 9.7 2 2 0.027 1.6e+02 0.9 2.5 163 268 1637 1765 1600 1795 0.49 Myc amino-terminal region +SBP_bac_3 PF00497.13 225 jgi|Monbr1|5272|fgenesh1_pg.scaffold_2000588 - 475 0.00015 20.8 0.0 1 1 7.5e-08 0.00018 20.5 0.0 97 171 260 331 46 351 0.79 Bacterial extracellular solute-binding proteins, family 3 +Lig_chan PF00060.19 147 jgi|Monbr1|5272|fgenesh1_pg.scaffold_2000588 - 475 0.041 13.2 0.6 1 1 2.6e-05 0.061 12.7 0.4 8 87 168 250 162 380 0.77 Ligand-gated ion channel +VKOR PF07884.7 138 jgi|Monbr1|5272|fgenesh1_pg.scaffold_2000588 - 475 0.2 11.2 1.5 1 1 0.00024 0.57 9.7 0.9 45 97 178 251 162 262 0.70 Vitamin K epoxide reductase family +DUF2069 PF09842.2 109 jgi|Monbr1|5272|fgenesh1_pg.scaffold_2000588 - 475 0.85 9.2 3.4 1 1 0.001 2.4 7.8 2.3 18 95 146 221 130 232 0.72 Predicted membrane protein (DUF2069) +Na_sulph_symp PF00939.12 471 jgi|Monbr1|5272|fgenesh1_pg.scaffold_2000588 - 475 1 7.8 3.8 1 1 0.00067 1.6 7.2 2.6 70 139 179 263 142 288 0.73 Sodium:sulfate symporter transmembrane region +Cytochrom_B_N PF00033.12 188 jgi|Monbr1|5303|fgenesh1_pg.scaffold_2000619 - 199 6.3e-22 77.5 7.8 1 1 1.3e-25 7.8e-22 77.2 5.4 2 185 10 178 9 181 0.91 Cytochrome b(N-terminal)/b6/petB +Ni_hydr_CYTB PF01292.13 182 jgi|Monbr1|5303|fgenesh1_pg.scaffold_2000619 - 199 2.2e-19 69.2 7.8 1 1 4.4e-23 2.6e-19 68.9 5.4 2 179 12 178 11 181 0.89 Prokaryotic cytochrome b561 +MFS_1 PF07690.9 353 jgi|Monbr1|5313|fgenesh1_pg.scaffold_2000629 - 492 5.1e-08 31.7 20.4 1 2 1.7e-06 0.0069 14.8 4.8 210 331 69 201 34 227 0.62 Major Facilitator Superfamily +MFS_1 PF07690.9 353 jgi|Monbr1|5313|fgenesh1_pg.scaffold_2000629 - 492 5.1e-08 31.7 20.4 2 2 8.4e-09 3.4e-05 22.4 3.6 154 353 253 485 243 485 0.58 Major Facilitator Superfamily +Wzz PF02706.8 152 jgi|Monbr1|5313|fgenesh1_pg.scaffold_2000629 - 492 0.091 12.2 0.1 1 1 5.8e-05 0.23 10.9 0.1 4 38 332 366 330 376 0.88 Chain length determinant protein +Bac_rhodopsin PF01036.11 233 jgi|Monbr1|5313|fgenesh1_pg.scaffold_2000629 - 492 1.7 7.3 5.0 1 3 0.03 1.2e+02 1.3 0.0 154 190 50 86 41 99 0.75 Bacteriorhodopsin-like protein +Bac_rhodopsin PF01036.11 233 jgi|Monbr1|5313|fgenesh1_pg.scaffold_2000629 - 492 1.7 7.3 5.0 2 3 0.45 1.8e+03 -2.6 0.1 143 147 157 161 119 194 0.55 Bacteriorhodopsin-like protein +Bac_rhodopsin PF01036.11 233 jgi|Monbr1|5313|fgenesh1_pg.scaffold_2000629 - 492 1.7 7.3 5.0 3 3 0.00096 3.8 6.2 0.7 4 60 434 489 432 491 0.90 Bacteriorhodopsin-like protein +Arf PF00025.14 175 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 7.6e-67 223.6 0.5 1 1 6.5e-70 8.6e-67 223.4 0.3 3 174 6 177 4 178 0.97 ADP-ribosylation factor family +Ras PF00071.15 162 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 1.9e-15 56.3 0.1 1 1 1.7e-18 2.2e-15 56.1 0.0 1 160 20 178 20 180 0.86 Ras family +SRPRB PF09439.3 181 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 3.1e-12 45.7 0.1 1 1 2.8e-15 3.8e-12 45.4 0.1 3 137 18 144 16 151 0.85 Signal recognition particle receptor beta subunit +Miro PF08477.6 119 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 1.6e-11 44.4 0.0 1 1 1.6e-14 2.2e-11 44.0 0.0 1 119 20 130 20 130 0.81 Miro-like protein +Gtr1_RagA PF04670.5 231 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 1.9e-10 40.0 0.3 1 1 2.9e-13 3.8e-10 39.0 0.2 1 135 20 143 20 157 0.79 Gtr1/RagA G protein conserved region +G-alpha PF00503.13 351 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 2.1e-09 36.5 0.2 1 2 0.0043 5.7 5.5 0.0 26 47 16 37 10 42 0.90 G-protein alpha subunit +G-alpha PF00503.13 351 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 2.1e-09 36.5 0.2 2 2 2.9e-10 3.8e-07 29.1 0.0 176 225 48 97 40 145 0.86 G-protein alpha subunit +GTP_EFTU PF00009.20 189 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 0.00015 20.9 0.0 1 2 0.15 1.9e+02 1.0 0.0 6 22 21 37 17 47 0.79 Elongation factor Tu GTP binding domain +GTP_EFTU PF00009.20 189 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 0.00015 20.9 0.0 2 2 9.1e-07 0.0012 17.9 0.0 55 183 49 174 44 180 0.80 Elongation factor Tu GTP binding domain +MutS_V PF00488.14 234 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 0.017 14.2 0.0 1 1 1.8e-05 0.023 13.7 0.0 41 129 17 106 5 108 0.86 MutS domain V +MuDR PF03108.8 67 jgi|Monbr1|5315|fgenesh1_pg.scaffold_2000631 - 182 0.091 12.0 0.0 1 1 0.00013 0.17 11.1 0.0 9 46 124 161 120 166 0.91 MuDR family transposase +X_fast-SP_rel PF06669.4 70 jgi|Monbr1|5318|fgenesh1_pg.scaffold_2000634 - 125 0.012 15.2 1.4 1 1 2.9e-06 0.017 14.7 1.0 28 69 7 49 3 50 0.92 Xylella fastidiosa surface protein related +KRTAP PF11759.1 66 jgi|Monbr1|5318|fgenesh1_pg.scaffold_2000634 - 125 0.25 11.3 17.8 1 1 8.6e-05 0.51 10.3 12.4 4 44 46 84 40 99 0.81 Keratin-associated matrix +PRP38 PF03371.8 173 jgi|Monbr1|5319|fgenesh1_pg.scaffold_2000635 - 179 8e-64 214.0 0.0 1 1 8.9e-68 1.1e-63 213.7 0.0 6 166 11 170 7 172 0.98 PRP38 family +TBC PF00566.11 214 jgi|Monbr1|5351|fgenesh1_pg.scaffold_2000667 - 391 4.3e-27 94.6 0.2 1 1 5.3e-31 6.3e-27 94.1 0.1 3 214 52 252 50 252 0.92 TBC domain +UME PF08064.6 107 jgi|Monbr1|5354|fgenesh1_pg.scaffold_2000670 - 1005 0.11 12.1 2.6 1 3 3.7e-05 0.44 10.2 0.1 56 104 354 404 348 407 0.82 UME (NUC010) domain +UME PF08064.6 107 jgi|Monbr1|5354|fgenesh1_pg.scaffold_2000670 - 1005 0.11 12.1 2.6 2 3 0.18 2.1e+03 -1.7 0.0 57 86 618 647 611 657 0.84 UME (NUC010) domain +UME PF08064.6 107 jgi|Monbr1|5354|fgenesh1_pg.scaffold_2000670 - 1005 0.11 12.1 2.6 3 3 0.22 2.6e+03 -1.9 0.0 48 66 887 905 881 935 0.73 UME (NUC010) domain +Gal-3-0_sulfotr PF06990.4 402 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 1.6e-11 43.2 0.9 1 2 9e-05 0.27 9.5 0.0 58 94 986 1022 954 1027 0.79 Galactose-3-O-sulfotransferase +Gal-3-0_sulfotr PF06990.4 402 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 1.6e-11 43.2 0.9 2 2 1.4e-11 4.2e-08 31.9 0.1 196 314 1112 1238 1100 1256 0.70 Galactose-3-O-sulfotransferase +Fringe PF02434.9 252 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 1.7e-10 40.2 0.2 1 2 0.14 4.1e+02 -0.4 0.3 45 86 160 201 156 218 0.84 Fringe-like +Fringe PF02434.9 252 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 1.7e-10 40.2 0.2 2 2 4e-13 1.2e-09 37.4 0.0 92 175 354 436 345 459 0.84 Fringe-like +DUF526 PF04380.6 70 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 0.27 10.9 1.3 1 3 0.49 1.4e+03 -1.0 0.0 21 45 255 280 247 285 0.69 Protein of unknown function (DUF526) +DUF526 PF04380.6 70 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 0.27 10.9 1.3 2 3 0.00044 1.3 8.7 0.2 6 45 1124 1163 1118 1172 0.81 Protein of unknown function (DUF526) +DUF526 PF04380.6 70 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 0.27 10.9 1.3 3 3 3.1 9.3e+03 -3.6 0.1 1 31 1208 1238 1208 1240 0.79 Protein of unknown function (DUF526) +Syndecan PF01034.13 328 jgi|Monbr1|5363|fgenesh1_pg.scaffold_2000679 - 1767 0.4 10.2 7.8 1 1 0.00023 0.69 9.4 5.4 123 243 107 227 86 264 0.65 Syndecan domain +Rad17 PF03215.8 498 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 1.9e-17 62.9 0.0 1 2 6.4e-16 7.7e-13 47.7 0.0 48 135 5 90 2 91 0.85 Rad17 cell cycle checkpoint protein +Rad17 PF03215.8 498 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 1.9e-17 62.9 0.0 2 2 1.6e-05 0.019 13.4 0.1 239 263 93 117 90 144 0.85 Rad17 cell cycle checkpoint protein +AAA PF00004.22 130 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.00061 19.7 0.1 1 1 1.2e-06 0.0014 18.5 0.0 2 28 6 32 5 118 0.78 ATPase family associated with various cellular activities (AAA) +AAA_5 PF07728.7 139 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.0032 16.8 0.0 1 1 5.5e-06 0.0065 15.8 0.0 2 27 5 30 4 39 0.85 AAA domain (dynein-related subfamily) +NACHT PF05729.5 166 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.0034 16.7 0.0 1 2 8.2e-06 0.0097 15.2 0.0 2 23 4 25 3 32 0.90 NACHT domain +NACHT PF05729.5 166 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.0034 16.7 0.0 2 2 1.4 1.7e+03 -1.9 0.0 35 71 127 162 110 170 0.71 NACHT domain +Arch_ATPase PF01637.11 234 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.01 15.2 0.0 1 1 9.9e-06 0.012 15.0 0.0 21 82 3 63 1 117 0.63 Archaeal ATPase +cobW PF02492.12 173 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.01 14.9 0.0 1 1 1.2e-05 0.015 14.4 0.0 1 38 3 42 3 97 0.79 CobW/HypB/UreG, nucleotide-binding domain +RNA_helicase PF00910.15 107 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.014 15.3 0.0 1 1 1.8e-05 0.022 14.6 0.0 2 26 6 30 5 60 0.65 RNA helicase +Viral_helicase1 PF01443.11 226 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.02 14.1 0.0 1 1 2.5e-05 0.03 13.5 0.0 2 53 6 56 5 70 0.73 Viral (Superfamily 1) RNA helicase +DUF258 PF03193.9 161 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.022 13.6 0.0 1 1 3.1e-05 0.037 12.9 0.0 37 65 4 32 2 42 0.89 Protein of unknown function, DUF258 +UPF0079 PF02367.10 123 jgi|Monbr1|5377|fgenesh1_pg.scaffold_2000693 - 219 0.1 11.8 0.0 1 1 0.00018 0.22 10.8 0.0 18 39 5 26 1 103 0.83 Uncharacterised P-loop hydrolase UPF0079 +PMG PF05287.5 180 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 2e-06 27.4 0.0 1 3 0.0035 21 4.5 0.0 97 174 22 99 9 104 0.82 PMG protein +PMG PF05287.5 180 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 2e-06 27.4 0.0 2 3 0.00028 1.7 8.1 0.0 119 169 104 154 93 179 0.56 PMG protein +PMG PF05287.5 180 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 2e-06 27.4 0.0 3 3 7.5e-05 0.45 10.0 0.1 112 164 187 239 171 309 0.58 PMG protein +Aegerolysin PF06355.6 131 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 1 8.9 7.4 1 4 0.0035 21 4.6 0.0 18 54 51 87 44 92 0.89 Aegerolysin +Aegerolysin PF06355.6 131 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 1 8.9 7.4 2 4 0.05 3e+02 0.9 0.0 19 49 112 142 95 154 0.54 Aegerolysin +Aegerolysin PF06355.6 131 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 1 8.9 7.4 3 4 0.021 1.2e+02 2.1 0.3 49 55 182 188 146 242 0.63 Aegerolysin +Aegerolysin PF06355.6 131 jgi|Monbr1|5381|fgenesh1_pg.scaffold_2000697 - 382 1 8.9 7.4 4 4 0.04 2.4e+02 1.2 0.0 36 69 254 292 236 295 0.69 Aegerolysin +Rgp1 PF08737.3 414 jgi|Monbr1|5392|fgenesh1_pg.scaffold_2000708 - 275 3.9e-10 39.0 0.0 1 2 0.056 6.7e+02 -1.3 0.0 1 22 35 56 35 65 0.85 Rgp1 +Rgp1 PF08737.3 414 jgi|Monbr1|5392|fgenesh1_pg.scaffold_2000708 - 275 3.9e-10 39.0 0.0 2 2 1e-13 1.2e-09 37.4 0.0 305 396 158 248 151 255 0.90 Rgp1 +Init_tRNA_PT PF04179.5 451 jgi|Monbr1|5406|fgenesh1_pg.scaffold_2000722 - 850 2.3e-71 240.7 0.0 1 1 2.7e-75 3.2e-71 240.2 0.0 2 256 398 678 397 710 0.92 Initiator tRNA phosphoribosyl transferase +EamA PF00892.13 126 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 5.1e-18 65.0 31.0 1 4 0.41 7e+02 -0.1 0.1 49 74 4 28 2 33 0.56 EamA-like transporter family +EamA PF00892.13 126 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 5.1e-18 65.0 31.0 2 4 5.2e-13 8.9e-10 38.3 3.5 3 124 19 149 17 151 0.83 EamA-like transporter family +EamA PF00892.13 126 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 5.1e-18 65.0 31.0 3 4 1.1 1.8e+03 -1.4 0.1 50 71 256 277 245 282 0.68 EamA-like transporter family +EamA PF00892.13 126 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 5.1e-18 65.0 31.0 4 4 3.8e-12 6.4e-09 35.6 9.0 18 124 296 407 271 409 0.90 EamA-like transporter family +UAA PF08449.4 303 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 1.9e-07 29.9 9.5 1 2 0.075 1.3e+02 0.9 0.1 17 142 119 157 104 179 0.58 UAA transporter family +UAA PF08449.4 303 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 1.9e-07 29.9 9.5 2 2 1.1e-10 1.9e-07 29.9 6.6 147 298 253 410 230 415 0.86 UAA transporter family +Nuc_sug_transp PF04142.8 238 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 0.077 11.8 6.4 1 2 0.029 49 2.6 1.4 41 122 96 274 82 348 0.61 Nucleotide-sugar transporter +Nuc_sug_transp PF04142.8 238 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 0.077 11.8 6.4 2 2 0.00014 0.24 10.2 0.1 48 99 368 419 353 426 0.84 Nucleotide-sugar transporter +Branch_AA_trans PF05525.6 428 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 0.47 8.6 4.1 1 1 0.0006 1 7.5 2.8 289 335 348 394 308 406 0.83 Branched-chain amino acid transport protein +DUF914 PF06027.5 335 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 0.62 8.5 4.0 1 1 0.0009 1.5 7.2 2.7 208 313 313 417 295 430 0.62 Eukaryotic protein of unknown function (DUF914) +UPF0546 PF10639.2 113 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 1.5 8.3 4.4 1 2 0.12 2e+02 1.4 0.0 47 64 263 280 230 284 0.76 Uncharacterised protein family UPF0546 +UPF0546 PF10639.2 113 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 1.5 8.3 4.4 2 2 0.0027 4.5 6.8 1.1 68 110 363 405 321 408 0.84 Uncharacterised protein family UPF0546 +DUF2566 PF10753.2 55 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 1.7 8.3 4.2 1 2 0.55 9.3e+02 -0.5 0.0 10 31 309 330 303 346 0.74 Protein of unknown function (DUF2566) +DUF2566 PF10753.2 55 jgi|Monbr1|5412|fgenesh1_pg.scaffold_2000728 - 431 1.7 8.3 4.2 2 2 0.0022 3.7 7.2 1.4 30 53 358 381 339 383 0.84 Protein of unknown function (DUF2566) diff --git a/forester/test_data/hmmscan30b3_output_2 b/forester/test_data/hmmscan30b3_output_2 new file mode 100644 index 0000000..77c1d9e --- /dev/null +++ b/forester/test_data/hmmscan30b3_output_2 @@ -0,0 +1,72 @@ +# --- full sequence --- -------------- this domain ------------- hmm coord ali coord env coord +# target name accession tlen query name accession qlen E-value score bias # of c-Evalue i-Evalue score bias from to from to from to acc description of target +#------------------- ---------- ----- -------------------- ---------- ----- --------- ------ ----- --- --- --------- --------- ------ ----- ----- ----- ----- ----- ----- ----- ---- --------------------- +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 1 9 4e-06 0.012 15.5 0.0 4 51 1 47 1 47 0.97 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 2 9 0.25 7.5e+02 0.1 0.0 1 12 50 61 50 63 0.84 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 3 9 0.081 2.4e+02 1.7 0.0 29 50 79 99 76 100 0.81 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 4 9 2.4e-16 7.2e-13 48.2 0.2 1 51 103 150 103 150 0.95 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 5 9 6.7e-18 2e-14 53.2 0.7 2 51 154 205 153 205 0.88 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 6 9 3.1e-12 9.4e-09 35.0 0.0 1 51 208 253 208 253 0.94 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 7 9 3.7e-10 1.1e-06 28.4 0.3 1 51 256 305 256 305 0.97 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 8 9 3e-09 9e-06 25.5 0.0 2 39 309 348 308 352 0.85 Regulator of chromosome condensation (RCC1) repeat +RCC1 PF00415.11 51 jgi|Monbr1|55|gw1.3.11.1 - 850 3.6e-60 199.6 22.3 9 9 4 1.2e+04 -3.9 0.0 23 35 541 553 539 554 0.80 Regulator of chromosome condensation (RCC1) repeat +HECT PF00632.18 308 jgi|Monbr1|55|gw1.3.11.1 - 850 1.6e-56 191.4 0.0 1 1 8e-60 2.4e-56 190.8 0.0 22 301 562 830 533 833 0.84 HECT-domain (ubiquitin-transferase) +Cupin_2 PF07883.4 71 jgi|Monbr1|55|gw1.3.11.1 - 850 0.014 14.5 0.0 1 2 0.041 1.2e+02 1.9 0.0 21 37 42 59 33 65 0.80 Cupin domain +Cupin_2 PF07883.4 71 jgi|Monbr1|55|gw1.3.11.1 - 850 0.014 14.5 0.0 2 2 0.00017 0.5 9.6 0.0 26 57 255 287 248 297 0.87 Cupin domain +NHL PF01436.14 28 jgi|Monbr1|55|gw1.3.11.1 - 850 0.031 13.9 0.5 1 3 0.47 1.4e+03 -0.8 0.0 5 16 146 157 146 158 0.88 NHL repeat +NHL PF01436.14 28 jgi|Monbr1|55|gw1.3.11.1 - 850 0.031 13.9 0.5 2 3 0.018 54 3.7 0.0 2 16 198 212 197 212 0.89 NHL repeat +NHL PF01436.14 28 jgi|Monbr1|55|gw1.3.11.1 - 850 0.031 13.9 0.5 3 3 0.0054 16 5.3 0.1 5 17 301 313 301 313 0.97 NHL repeat +ABC_membrane PF00664.16 275 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.9e-58 197.7 23.2 1 2 2.9e-30 1.4e-27 96.4 9.2 4 274 70 335 67 336 0.89 ABC transporter transmembrane region +ABC_membrane PF00664.16 275 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.9e-58 197.7 23.2 2 2 1.7e-33 8.6e-31 107.0 1.5 1 273 731 1008 727 1010 0.93 ABC transporter transmembrane region +ABC_tran PF00005.20 118 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.4e-38 129.6 0.0 1 2 2.7e-18 1.4e-15 57.4 0.0 1 117 465 575 465 576 0.96 ABC transporter +ABC_tran PF00005.20 118 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.4e-38 129.6 0.0 2 2 4.4e-22 2.2e-19 69.6 0.0 1 118 1097 1221 1097 1221 0.95 ABC transporter +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 1 4 0.018 9 5.1 0.5 27 51 454 478 446 504 0.77 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 2 4 0.0062 3.1 6.6 0.0 120 210 514 618 493 625 0.76 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 3 4 0.5 2.5e+02 0.4 0.0 28 42 1087 1101 1072 1117 0.81 RecF/RecN/SMC N terminal domain +SMC_N PF02463.12 220 jgi|Monbr1|82|gw1.7.5.1 - 1291 4e-07 29.1 1.0 4 4 0.00028 0.14 11.0 0.0 135 209 1174 1262 1111 1268 0.78 RecF/RecN/SMC N terminal domain +Miro PF08477.6 119 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.9e-05 23.2 0.2 1 2 7.2e-05 0.036 14.2 0.0 2 37 454 483 454 526 0.69 Miro-like protein +Miro PF08477.6 119 jgi|Monbr1|82|gw1.7.5.1 - 1291 5.9e-05 23.2 0.2 2 2 0.023 12 6.1 0.0 1 16 1085 1100 1085 1124 0.86 Miro-like protein +DUF258 PF03193.9 161 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00029 19.7 0.1 1 2 0.0011 0.53 9.1 0.1 35 67 451 483 441 487 0.88 Protein of unknown function, DUF258 +DUF258 PF03193.9 161 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00029 19.7 0.1 2 2 0.0024 1.2 8.0 0.0 36 68 1084 1116 1068 1142 0.72 Protein of unknown function, DUF258 +DUF87 PF01935.10 229 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00096 18.7 0.0 1 2 0.03 15 5.0 0.0 10 47 436 475 430 482 0.81 Domain of unknown function DUF87 +DUF87 PF01935.10 229 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.00096 18.7 0.0 2 2 0.0005 0.25 10.8 0.0 25 47 1085 1107 1075 1115 0.83 Domain of unknown function DUF87 +ArgK PF03308.9 267 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0014 17.1 0.0 1 2 0.00086 0.42 9.0 0.0 17 54 439 476 422 490 0.81 ArgK protein +ArgK PF03308.9 267 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0014 17.1 0.0 2 2 0.0081 4 5.8 0.0 18 50 1072 1104 1064 1118 0.80 ArgK protein +Dynamin_N PF00350.16 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0029 17.1 0.0 1 2 2.2e-05 0.011 15.2 0.0 1 40 454 493 454 554 0.85 Dynamin family +Dynamin_N PF00350.16 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0029 17.1 0.0 2 2 6.6 3.3e+03 -2.6 0.0 1 15 1086 1100 1086 1105 0.84 Dynamin family +PRK PF00485.11 194 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0044 16.2 0.1 1 2 0.015 7.5 5.7 0.0 1 29 453 478 453 529 0.75 Phosphoribulokinase / Uridine kinase family +PRK PF00485.11 194 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0044 16.2 0.1 2 2 0.0025 1.2 8.2 0.0 2 24 1086 1108 1085 1132 0.86 Phosphoribulokinase / Uridine kinase family +FtsK_SpoIIIE PF01580.11 205 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0045 16.1 0.0 1 2 0.011 5.4 6.1 0.0 28 59 437 472 415 478 0.70 FtsK/SpoIIIE family +FtsK_SpoIIIE PF01580.11 205 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0045 16.1 0.0 2 2 0.0049 2.5 7.2 0.0 29 58 1074 1103 1060 1107 0.87 FtsK/SpoIIIE family +AAA PF00004.22 130 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0052 16.7 0.2 1 2 0.017 8.4 6.3 0.0 3 40 456 492 454 513 0.85 ATPase family associated with various cellular activities (AAA) +AAA PF00004.22 130 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0052 16.7 0.2 2 2 0.024 12 5.8 0.0 4 95 1089 1243 1086 1264 0.60 ATPase family associated with various cellular activities (AAA) +GSPII_E PF00437.13 282 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0055 15.3 0.0 1 2 0.0016 0.78 8.2 0.0 134 167 447 480 410 486 0.83 Type II/IV secretion system protein +GSPII_E PF00437.13 282 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.0055 15.3 0.0 2 2 0.035 17 3.8 0.0 141 161 1086 1106 1071 1116 0.79 Type II/IV secretion system protein +NB-ARC PF00931.15 285 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.019 13.5 1.2 1 3 0.041 20 3.5 0.0 20 58 452 494 445 522 0.73 NB-ARC domain +NB-ARC PF00931.15 285 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.019 13.5 1.2 2 3 0.0075 3.7 6.0 0.0 22 40 1086 1104 1074 1112 0.84 NB-ARC domain +NB-ARC PF00931.15 285 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.019 13.5 1.2 3 3 0.34 1.7e+02 0.5 0.1 74 106 1216 1248 1204 1265 0.82 NB-ARC domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.02 13.5 0.0 1 2 0.0086 4.2 5.9 0.0 21 47 452 478 442 689 0.81 KAP family P-loop domain +KAP_NTPase PF07693.7 325 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.02 13.5 0.0 2 2 0.019 9.4 4.8 0.0 23 107 1086 1262 1081 1271 0.71 KAP family P-loop domain +Zeta_toxin PF06414.5 201 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.072 11.8 0.7 1 2 0.0047 2.3 6.9 0.1 19 44 454 480 447 484 0.82 Zeta toxin +Zeta_toxin PF06414.5 201 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.072 11.8 0.7 2 2 0.088 44 2.7 0.0 21 49 1088 1117 1085 1122 0.85 Zeta toxin +ATP-synt_ab PF00006.18 215 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.077 12.1 0.1 1 2 0.0076 3.8 6.6 0.0 8 43 444 479 440 659 0.85 ATP synthase alpha/beta family, nucleotide-binding domain +ATP-synt_ab PF00006.18 215 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.077 12.1 0.1 2 2 0.13 64 2.6 0.0 16 35 1084 1103 1078 1113 0.87 ATP synthase alpha/beta family, nucleotide-binding domain +Arch_ATPase PF01637.11 234 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.091 12.1 0.0 1 2 0.042 21 4.3 0.0 22 68 453 505 447 549 0.73 Archaeal ATPase +Arch_ATPase PF01637.11 234 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.091 12.1 0.0 2 2 0.033 16 4.7 0.0 25 44 1088 1107 1082 1134 0.85 Archaeal ATPase +PTS_EIIC PF02378.11 321 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.11 11.0 4.2 1 3 0.71 3.5e+02 -0.6 0.0 68 127 60 112 57 123 0.81 Phosphotransferase system, EIIC +PTS_EIIC PF02378.11 321 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.11 11.0 4.2 2 3 1.6 8e+02 -1.7 0.0 223 274 725 795 695 807 0.54 Phosphotransferase system, EIIC +PTS_EIIC PF02378.11 321 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.11 11.0 4.2 3 3 0.00026 0.13 10.7 0.2 136 184 834 885 828 901 0.87 Phosphotransferase system, EIIC +MobB PF03205.7 137 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.12 11.8 0.6 1 2 0.018 8.9 5.8 0.1 3 26 454 477 452 484 0.86 Molybdopterin guanine dinucleotide synthesis protein B +MobB PF03205.7 137 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.12 11.8 0.6 2 2 0.071 35 3.8 0.0 3 22 1086 1105 1085 1111 0.83 Molybdopterin guanine dinucleotide synthesis protein B +DUF265 PF03266.8 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 11.6 0.5 1 2 0.21 1e+02 2.1 0.0 2 26 454 478 453 487 0.85 Protein of unknown function, DUF265 +DUF265 PF03266.8 168 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 11.6 0.5 2 2 0.0072 3.6 6.9 0.0 1 26 1085 1110 1085 1128 0.78 Protein of unknown function, DUF265 +RNA_helicase PF00910.15 107 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 12.1 0.2 1 2 0.2 98 2.8 0.0 3 29 456 482 454 521 0.69 RNA helicase +RNA_helicase PF00910.15 107 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.13 12.1 0.2 2 2 0.012 6.1 6.7 0.0 3 23 1088 1108 1086 1121 0.81 RNA helicase +CoaE PF01121.13 180 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.23 10.5 1.3 1 2 0.0065 3.2 6.7 0.1 2 24 453 476 452 496 0.78 Dephospho-CoA kinase +CoaE PF01121.13 180 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.23 10.5 1.3 2 2 0.21 1e+02 1.8 0.0 3 20 1086 1103 1085 1124 0.84 Dephospho-CoA kinase +NhaB PF06450.5 515 jgi|Monbr1|82|gw1.7.5.1 - 1291 0.57 8.4 2.7 1 1 0.002 0.97 7.6 1.9 96 176 75 158 63 210 0.85 Bacterial Na+/H+ antiporter B (NhaB) +Pex24p PF06398.4 354 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.8 6.9 6.2 1 2 0.0035 1.7 7.0 0.1 134 202 174 245 151 282 0.81 Integral peroxisomal membrane peroxin +Pex24p PF06398.4 354 jgi|Monbr1|82|gw1.7.5.1 - 1291 1.8 6.9 6.2 2 2 0.26 1.3e+02 0.8 1.7 44 156 861 976 856 994 0.66 Integral peroxisomal membrane peroxin +DNA_pol_B PF00136.14 467 jgi|Monbr1|107|gw1.5.19.1 - 1089 3.3e-120 401.7 0.3 1 1 1.2e-123 4.9e-120 401.1 0.2 1 464 475 932 475 935 0.90 DNA polymerase family B +DNA_pol_B_exo PF03104.12 317 jgi|Monbr1|107|gw1.5.19.1 - 1089 8.3e-40 136.3 0.0 1 1 3.1e-43 1.2e-39 135.7 0.0 3 316 51 395 49 396 0.92 DNA polymerase family B, exonuclease domain +DNA_pol_B_new PF03104.12 317 jgi|Monbr1|107|gw1.5.19.2 - 1089 8.3e-40 136.3 0.0 1 1 3.1e-43 1.2e-39 135.7 0.0 3 316 51 395 49 396 0.92 DNA polymerase family B, exonuclease domain diff --git a/forester/test_data/midpoint_rooting_neg_bl.nh b/forester/test_data/midpoint_rooting_neg_bl.nh new file mode 100644 index 0000000..010a195 --- /dev/null +++ b/forester/test_data/midpoint_rooting_neg_bl.nh @@ -0,0 +1 @@ +(((((Nevada:2.18821,Florida:2.18821):1.65615,(California:2.62920,Arizona:2.62920):1.21516):5.33716,((((Missouri:0.45603,Delaware:0.45603):0.07880,Washington:0.53483):1.21752,((South_Dako:0.62049,Arkansas:0.62049):0.73251,(((Oklahoma:0.27955,Colorado:0.27955):0.27670,Louisiana:0.55625):0.05870,Mississipp:0.61495):0.73804):0.39936):1.92273,((Rhode_Isla:2.35221,Kentucky:2.35221):0.12516,(Oregon:0.74278,Michigan:0.74278):1.73459):1.19771):5.50644):-3.79953,(((Wyoming:1.59475,Montana:1.59475):0.68090,((Nebraska:0.78639,Iowa:0.78639):0.51349,((Texas:0.23597,New_Mexico:0.23597):0.96343,North_Dako:1.19940):0.10048):0.97577):0.71673,(((((Wisconsin:0.47817,North_Caro:0.47817):0.31884,South_Caro:0.79701):1.02342,Alabama:1.82042):-0.51219,((West_Virgi:0.28732,Tennessee:0.28732):0.33230,(Ohio:0.46883,Indiana:0.46883):0.15079):0.68861):1.10440,(((((Minnesota:0.30805,Maryland:0.30805):0.56496,Utah:0.87301):-0.32441,Pennsylvan:0.54860):0.28559,((Idaho:0.56558,Georgia:0.56558):0.10760,Virginia:0.67317):0.16102):1.20441,((((New_Hampsh:0.56301,Maine:0.56301):0.03371,Massachuse:0.59672):1.09407,(New_Jersey:1.45604,Illinois:1.45604):0.23475):-0.12520,((New_York:12.94928,Alaska:12.94928):-11.53873,((Kansas:0.10408,Connecticu:0.10408):0.05649,Vermont:0.16057):1.24997):0.15504):0.47302):0.37403):0.57974):2.38961):-4.02441,Hawaii:1.35758); diff --git a/forester/test_data/msa_1.txt b/forester/test_data/msa_1.txt new file mode 100644 index 0000000..04f95aa --- /dev/null +++ b/forester/test_data/msa_1.txt @@ -0,0 +1,27 @@ +CLUSTAL v2 +12 12 + +sequence_1 abcdef +sequence_2 efghix +sequence_3 klmnxp + +ee +ff +hh + +sequence_1 ee +sequence_2 ff +sequence_3 hh + ...:: +sequence_1 ee +sequence_2 ff +sequence_3 hh + ** +sequence_1 ee +sequence_2 ff +sequence_3 hh + +//ee +xx +yy +zz \ No newline at end of file diff --git a/forester/test_data/msa_2.txt b/forester/test_data/msa_2.txt new file mode 100644 index 0000000..6ed1454 --- /dev/null +++ b/forester/test_data/msa_2.txt @@ -0,0 +1,13 @@ +PROBCONS v44 + +sequence_1 abcdef + + x + x + +sequence_2 efghix + yy + **** +sequence_3 klmnxp + z + z \ No newline at end of file diff --git a/forester/test_data/msa_3.txt b/forester/test_data/msa_3.txt new file mode 100644 index 0000000..0cce6da --- /dev/null +++ b/forester/test_data/msa_3.txt @@ -0,0 +1,33 @@ +MUSCLE (blah +12 12 + +sequence_1 abcdef +sequence_2 efghix +sequence_3 klmnxp + +ee +ff +hh + +sequence_1 ee + ee +sequence_2 ff + ff +sequence_3 hh + hh + ... :: + + ** +sequence_1 ee +sequence_2 ff +sequence_3 hh + +//ee +xx +yy +zz + + + + + \ No newline at end of file diff --git a/forester/test_data/ncbi.fasta b/forester/test_data/ncbi.fasta new file mode 100644 index 0000000..7c1a7fd --- /dev/null +++ b/forester/test_data/ncbi.fasta @@ -0,0 +1,101 @@ +>gi|14669630|gb|AAK72004.1| Bcl2-beta [Peromyscus polionotus] +WDAGDADAAPLGAAPTPGIFSFQPQSNPTPAVLRDTAARTSPPRPIVATAGPALSPVPPVVHLTLRRAGD +DFSRRYRRDFAEMSSQLHLTP + +>gi|262050658|ref|NP_001159958.1| apoptosis regulator Bcl-2 [Bos taurus] +MAHAGGTGYDNREIVMKYIHYKLSQRGYEWDAGDAGAAPPGAAPAPGILSSQPGRTPAPSRTSPPPPPAA +AAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAF +FEFGGVMCVESVNREMSPLVDSIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKAL +LSLALVGACITLGAYLGHK + +>gi|231633|sp|P10417.2|BCL2_MOUSE RecName: Full=Apoptosis regulator Bcl-2 +MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHREMAARTS +PLRPLVATAGPALSPVPPCVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN +WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFS +WLSLKTLLSLALVGACITLGAYLGHK + +>gi|67003896|gb|AAY60777.1| B-cell CLL/lymphoma 2 [Bos taurus] +PSRTSPPPPPAAAAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELF +RDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDSIALWMTEYLNRHLHTWIQDNGGWVGARLDVSLSGTP +RSQCGPSGGVWLGPGSRAGRWSKTTCVASLSLPLQRALPANPTVITPSLETLLPLSQPLRSKDPAFAAQ + +>gi|133893254|ref|NP_803129.2| apoptosis regulator Bcl-2 isoform 2 [Mus musculus] +MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTS +PLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN +WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWVGACLVE + +>gi|133892547|ref|NP_033871.2| apoptosis regulator Bcl-2 isoform 1 [Mus musculus] +MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTS +PLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN +WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFS +WLSLKTLLSLALVGACITLGAYLGHK + +>gi|231632|sp|P10415.2|BCL2_HUMAN RecName: Full=Apoptosis regulator Bcl-2 +MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTS +PLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRD +GVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLF +DFSWLSLKTLLSLALVGACITLGAYLGHK + +>gi|72198346|ref|NP_000648.2| apoptosis regulator Bcl-2 beta isoform [Homo sapiens] +MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTS +PLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRD +GVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWVGALGDVSLG + +>gi|72198189|ref|NP_000624.2| apoptosis regulator Bcl-2 alpha isoform [Homo sapiens] +MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTS +PLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRD +GVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLF +DFSWLSLKTLLSLALVGACITLGAYLGHK + +>gi|22652877|gb|AAN03862.1| Bcl2 protein [Bos taurus] +MAHAGGTGYDNREIVMKYIHYKLSQRGYEWDAGDAGAAPPGAAPAPGILSSQPGRTPAPSRTSPPPPPAA +AAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAF +FEFGGVMCVESVNREMSPLVDSIALWMTEYLNRHLHTWIQDNGGW + +>gi|66365673|gb|AAH95964.1| Bcl2 protein [Mus musculus] +MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTS +PLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN +WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFS +WLSLKTLLSLALVGACITLGAYLGHK + +>gi|296473656|gb|DAA15771.1| apoptosis regulator Bcl-2 [Bos taurus] +MAHAGGTGYDNREIVMKYIHYKLSQRGYEWDAGDAGAAPPGAAPAPGILSSQPGRTPAPSRTSPPPPPAA +AAGPAPSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAF +FEFGGVMCVESVNREMSPLVDSIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKAL +LSLALVGACITLGAYLGHK + +>gi|68235697|gb|AAY88186.1| Bcl2 [Oryctolagus cuniculus] +CVESVNREMSPLVDNIAL + +>gi|408947|gb|AAA53662.1| BCL2 [Rattus norvegicus] +MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDTGDEDSAPLRAAPTPGIFSFQPESNRTPAVHRDTAARTS +PLRPLVANAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN +WGRIVAFFEFGGVMCVGSVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFS +WLSLKTLLSLALVGACITLGAYLGHK + +>gi|227150149|gb|ACP19736.1| bcl2 [Odontesthes bonariensis] +MSQNRELVVFYIKYKLSQRNYPLNHIVLNEPPNRTGAGDGGLGEEQSTETHANGTFTGTSPGTPPVSPLR +QQPLPSTTTTTRLDAVKEALRDTANEFELRYARAFSDLHSQLHITPATAYQSFENVMDEVFRDGVNWGRI +VGLFAFGGALCVECVEREMSPLVGRIVEWMTVYLDNHIQPWIQSQGGWERFAEIFGQDAAAESRRSQESF +KKWLLVGMTVVTGVVVGSLFAQKRL + +>gi|115607126|gb|ABJ16409.1| BCL2 [Felis catus] +GRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDA +FVELYGPSMQPLFDFSWLSLKALLSLALVGACITLGAYLG + +>gi|56785771|gb|AAW29023.1| Bcl2 [Epinephelus coioides] +DEVFRDGVNWGRIVGLFAFGGALCVECVEKEMSPLVGRIIEWMTVYLDNHIQPWIQSQRGWERFAEIFGQ +DAAAESRRSQESFKKWLLAGMTLVTGVVVGSLIAQKRL + +>gi|56684462|gb|AAW21970.1| Bcl2 [Danio rerio] +MANEISYDNRNIVEKYLKHKLSKRGYVWKCQSSAEEDDTFNKAVEESSPNSDRRLQAPSAGGGNNSECLI +ARVTRSDPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVFNPNSAQRSFLTVAEELFRDGVNWGRIIAFF +EFGGTMCVESVNREMASQVDNIAHWMTDYLNGPLENWIEENGGWDAFVEMYGQQRDSVFHPFSYLTKVLG +LAALGLAGVTIGAFFAQK + +>gi|71834668|ref|NP_001025424.1| Bcl2 [Danio rerio] +MANEISYDNRNIVEKYLKHKLSKRGYVWKCQSSAEEDDTFNKAVEESSPNSDRRLQAPSAGGGNNSECLI +ARVTRSDPHLRLYRVLRDAGDEIERIYQREFEEMSQQMVFNPNSAQRSFLTVAEELFRDGVNWGRIIAFF +EFGGTMCVESVNREMASQVDNIAHWMTDYLNGPLENWIEENGGWDAFVEMYGQQRDSVFHPFSYLTKVLG +LAALGLAGVTIGAFFAQK + diff --git a/forester/test_data/nexus_test_1.nex b/forester/test_data/nexus_test_1.nex new file mode 100644 index 0000000..e0d27ca --- /dev/null +++ b/forester/test_data/nexus_test_1.nex @@ -0,0 +1,5 @@ +#NEXUS +begin trees; +tree=(((Hippo,((Horse,(Monkey,Orangutan)),(Donkey,Mule))),((((Zebra,Camel),(Llama,Bison)),Elephant),((Buffalo, +(Sheep,Fox)),((Pig,GuineaPig),Cat)))),((((Dog,Rat),((Deer,Reindeer),Whale)),Rabbit),(Dolphin,Seal))) +end; \ No newline at end of file diff --git a/forester/test_data/nexus_test_2.nex b/forester/test_data/nexus_test_2.nex new file mode 100644 index 0000000..d6985b6 --- /dev/null +++ b/forester/test_data/nexus_test_2.nex @@ -0,0 +1,9 @@ + + #NEXUS + + begin trees ; + +tree 'name' = (1:0.212481,8:0.297838,(9:0.222729,((6:0.201563,7:0.194547):0.282035,(4:1.146091,(3:1.008881, +(10:0.384105,(2:0.235682,5:0.353432):0.323680):0.103875):0.413540):0.254687):0.095341):0.079254):0.000000; + + end ; \ No newline at end of file diff --git a/forester/test_data/nexus_test_3.nex b/forester/test_data/nexus_test_3.nex new file mode 100644 index 0000000..095523c --- /dev/null +++ b/forester/test_data/nexus_test_3.nex @@ -0,0 +1,4 @@ +#NEXUS +BEGIN TREES; +tree=[&U]((a,b),c); +END; \ No newline at end of file diff --git a/forester/test_data/nexus_test_4.nex b/forester/test_data/nexus_test_4.nex new file mode 100644 index 0000000..218fde3 --- /dev/null +++ b/forester/test_data/nexus_test_4.nex @@ -0,0 +1,89 @@ +#NEXUS + +[!Data from: + Young, D. A. 1981. Are the angiosperm primitively vesselless? + Systematic Botany. 6:313-330. + Character 9 coded "0" for OTU AUST, following Riggins and Farris (1983) +] + +begin assumptions; + options deftype = ord; +end; + + + begin trees; + utree 'tree 0' =(1:0.212481,8:0.297838,(9:0.222729,((6:0.201563,7:0.194547):0.282035,(4:1.146091,(3:1.008881, +(10:0.384105,(2:0.235682,5:0.353432):0.323680):0.103875):0.413540):0.254687):0.095341):0.079254):0.000000; + +tree "tree 1"= (1:0.212481,8:0.297838,(9:0.222729,((6:0.201563,7:0.194547):0.282035,(4:1.146091,(3:1.008881, +(10:0.384105,(2:0.235682,5:0.353432):0.323680):0.103875):0.413540):0.254687):0.095341):0.079254):0.000000 + + tree=[&U]((a,b),c); + utree=[&R]((a,b),c) + + tree=[&R]((a,b),c) + +tree=[&U]((a,b),c); +tree=[&R]((a,b),c); + + tree=[&R] + + ((a,b),c) + + TREE 'tree 8'=[&U]((a,b),c); + tree 'tree 9'=[&R]((a,b),c) + + tree 'tree 10'=[&R]((a,b),c) + +tree 'tree 11'=[&U]((a,b),c); +tree 'tree 12'=[&R]((a,b),c); + + tree 'tree 13' =[&R] + + ((a,b),c) + + + tree "tree 14" = [&R] + + (1:0.212481,8:0.297838,(9:0.222729,((6:0.201563,7:0.194547):0.282035,(4:1.146091,(3:1.008881, + +(10:0.384105,(2:0.235682,5:0.353432):0.323680):0.103875):0.413540):0.254687):0.095341):0.079254):0.000000 + + tree "tree 15" = [&U] + + # (,) + # + # + + (1:0.212481,8:0.297838,(9 + + + + :0.222729,((6:0.201563,7: + 0.194547): + + 0.282035,(4:1.146091,(3:1.008881, + +(10:0.384105,(2:0.235682,5:0.353432):0.323680) + + + +:0.103875): + + + 0.413540): + 0.254687):0.095341):0.079254):0.000000 + +tree "tree 16"=[&R](1:0.212481,8:0.297838,(9:0.222729,((6:0.201563,7:0.194547):0.282035,(4:1.146091,(3:1.008881, +(10:0.384105,(2:0.235682,5:0.353432):0.323680):0.103875):0.413540):0.254687):0.095341):0.079254):0.000000 + +tree "tree 17"=[&U](1:0.212481,8:0.297838,(9:0.222729,((6:0.201563,7:0.194547):0.282035,(4:1.146091,(3:1.008881, +(10:0.384105,(2:0.235682,5:0.353432):0.323680):0.103875):0.413540):0.254687):0.095341):0.079254):0.000000; + + end; + + + + + + \ No newline at end of file diff --git a/forester/test_data/nexus_test_5.nex b/forester/test_data/nexus_test_5.nex new file mode 100644 index 0000000..eea5fa4 --- /dev/null +++ b/forester/test_data/nexus_test_5.nex @@ -0,0 +1,9 @@ +#NEXUS +Begin Taxa; + TaxLabels "Scarabaeus" Drosophila + Aranaeus; +End; +Begin Trees; + Tree Tree0=((1,2),3); +End; + \ No newline at end of file diff --git a/forester/test_data/nexus_test_6.nex b/forester/test_data/nexus_test_6.nex new file mode 100644 index 0000000..09a5a0e --- /dev/null +++ b/forester/test_data/nexus_test_6.nex @@ -0,0 +1,16 @@ +#NEXUS +Begin Taxa; + TaxLabels "Scarabaeus" Drosophila + Aranaeus; +End; +Begin Trees; + Translate beetle Scarabaeus, fly + Drosophila, spider + 'Aranaeus' ; + + Tree Tree0=[&U]((1,2),3); + Tree Tree1=[&U]((beetle,fly), + spider); + Tree Tree2=[&R]((Scarabaeus, + Drosophila),Aranaeus); +End; \ No newline at end of file diff --git a/forester/test_data/nexus_test_7.nex b/forester/test_data/nexus_test_7.nex new file mode 100644 index 0000000..ea35ec4 --- /dev/null +++ b/forester/test_data/nexus_test_7.nex @@ -0,0 +1,54 @@ +#NEXUS +Begin Taxa; + TaxLabels + "Scarabaeus" Drosophila + + + + Aranaeus + + ; +Endblock; +Begin Trees; + Translate beetle Scarabaeus, fly + Drosophila, spider + 'Aranaeus' + + ; + + UTree Tree0 = [&U] ((1,2),3); + + + UTree Tree1=[&U] ((beetle,fly), + spider) + + ; + Tree Tree2=[&R]((Scarabaeus, + Drosophila),Aranaeus) + + ; + +Endblock; + + +Begin Characters; + Dimensions NChar=7; + CharStateLabels + 1 '14-3-3', + 2 "2-Hacid_dh ", + 3 '2-Hacid_dh_C' , + 4 2-oxoacid_dh , + 5 '2OG-FeII_Oxy', + '3-HAO", + 7 '3_5_exonuc' ; + + Format DataType=Standard Symbols="01"; + Matrix + MOUSE 101111111 + NEMVE 101111111 + MONBE 111110111 + DICDI 101111111 + ARATH 111110111; + End; + + \ No newline at end of file diff --git a/forester/test_data/nexus_test_8.nex b/forester/test_data/nexus_test_8.nex new file mode 100644 index 0000000..e6a496a --- /dev/null +++ b/forester/test_data/nexus_test_8.nex @@ -0,0 +1,29 @@ +#NEXUS + +Begin Characters; + Dimensions NChar=7; + CharStateLabels + '14-3-3', + 2 "2-Hacid_dh ", +> +> 3 '14-3-3', +> 3 '14-3-3', + '2-Hacid_dh_C', + 4 2-oxoacid_dh , + + 5 '2OG-FeII_Oxy', + '3-HAO", + + 7 '3_5_exonuc' + + + ; + + Format DataType=Standard Symbols="01"; + Matrix + MOUSE 101111111 + NEMVE 101111111 + MONBE 111110111 + DICDI 101111111 + ARATH 111110111; + End; \ No newline at end of file diff --git a/forester/test_data/nexus_test_9.nex b/forester/test_data/nexus_test_9.nex new file mode 100644 index 0000000..490f2a4 --- /dev/null +++ b/forester/test_data/nexus_test_9.nex @@ -0,0 +1,33 @@ +#NEXUS + +Begin Characters; + Dimensions NChar=9; + ntax=5; + CharStateLabels + '14-3-3', + 2 "2-Hacid_dh ", +> +> 3 '14-3-3', +> 3 '14-3-3', + '2-Hacid_dh_C', + 4 2-oxoacid_dh , + + 5 '2OG-FeII_Oxy', + '3-HAO", + + 7 '3_5_exonuc' + + 8 'duf' + + 9 'bx' + + ; + + Format DataType=Standard Symbols="01"; + Matrix + MOUSE 101111111 + NEMVE 111111111 + MONBE 011110111 + DICDI 101111111 + ARATH 111110111; + End; \ No newline at end of file diff --git a/forester/test_data/obo_test b/forester/test_data/obo_test new file mode 100644 index 0000000..3c4e93b --- /dev/null +++ b/forester/test_data/obo_test @@ -0,0 +1,293 @@ +format-version: 1.2 +date: 05:10:2007 17:50 +saved-by: midori +auto-generated-by: OBO-Edit 1.101 +subsetdef: goslim_generic "Generic GO slim" +subsetdef: goslim_goa "GOA and proteome slim" +subsetdef: goslim_plant "Plant GO slim" +subsetdef: goslim_yeast "Yeast GO slim" +subsetdef: gosubset_prok "Prokaryotic GO subset" +default-namespace: gene_ontology +remark: cvs version: $Revision: 1.4 $ +[Term] +id: GO:0000001 +name: mitochondrion inheritance +namespace: biological_process +def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] +synonym: "mitochondrial inheritance" EXACT [] +is_a: GO:0048308 ! organelle inheritance +is_a: GO:0048311 ! mitochondrion distribution +is_obsolete: true +consider: GO:0009055 +[Term] +id:GO:0000002 +name:mitochondrial genome maintenance +namespace:biological_process +comment:comment +def:"The maintenance of the structure and integrity of the mitochondrial genome." [GOC:ai] +is_a:GO:0007005!mitochondrion organization and biogenesis +is_obsolete: false +xref: EC:2.4.1.- +xref: Reactome:7672 +xref: MetaCyc:SIROHEME-FERROCHELAT-RXN +xref: RESID:AA02376 +xref: UM-BBD_enzymeID:e0271 +relationship: part_of GO:0007052 ! mitotic spindle organization and biogenesis + + + [Term] +id: GO:0000003 +name: reproduction +namespace: biological_process +alt_id: GO:0019952 +alt_id: GO:0050876 +def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: goslim_generic +subset: goslim_plant +subset: gosubset_prok +synonym: "reproductive physiological process" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0000005 +name: ribosomal chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] +comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. +is_obsolete: true +consider: GO:0042254 +consider: GO:0051082 + +[Term] +id: GO:0000006 +name: high affinity zinc uptake transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0000007 +name: low-affinity zinc ion transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0000008 +name: thioredoxin +namespace: molecular_function +alt_id: GO:0000013 +def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] +comment: This term was made obsolete because it represents gene products. +is_obsolete: true +consider: GO:0030508 + +[Term] +id: GO:0000009 +name: alpha-1,6-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248] +xref: EC:2.4.1.- +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000010 +name: trans-hexaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30] +subset: gosubset_prok +synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] +synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30] +synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] +xref: EC:2.5.1.30 +xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0000011 +name: vacuole inheritance +namespace: biological_process +def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] +is_a: GO:0007033 ! vacuole organization and biogenesis +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0000012 +name: single strand break repair +namespace: biological_process +def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] +subset: gosubset_prok +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0000014 +name: single-stranded DNA specific endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0000015 +name: phosphopyruvate hydratase complex +namespace: cellular_component +def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "enolase complex" EXACT [] +is_a: GO:0043234 ! protein complex +is_a: GO:0044445 ! cytosolic part + +[Term] +id: GO:0000016 +name: lactase activity +namespace: molecular_function +def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] +xref: EC:3.2.1.108 +xref: MetaCyc:LACTASE-RXN +xref: Reactome:20536 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0000017 +name: alpha-glucoside transport +namespace: biological_process +def: "The directed movement of alpha-glucosides into, out of, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +is_a: GO:0042946 ! glucoside transport + +[Term] +id: GO:0000018 +name: regulation of DNA recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0000019 +name: regulation of mitotic recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] +synonym: "regulation of recombination within rDNA repeats" NARROW [] +is_a: GO:0000018 ! regulation of DNA recombination +relationship: part_of GO:0006312 ! mitotic recombination + +[Term] +id: GO:0000020 +name: negative regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +comment: This term was made obsolete because it describes a substrate-specific process. +is_obsolete: true +consider: GO:0045950 + +[Term] +id: GO:0000022 +name: mitotic spindle elongation +namespace: biological_process +def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] +synonym: "spindle elongation during mitosis" EXACT [] +is_a: GO:0051231 ! spindle elongation +relationship: part_of GO:0007052 ! mitotic spindle organization and biogenesis + +[Term] +id: GO:0000023 +name: maltose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malt sugar metabolic process" EXACT [] +synonym: "malt sugar metabolism" EXACT [] +synonym: "maltose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0000024 +name: maltose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malt sugar biosynthesis" EXACT [] +synonym: "malt sugar biosynthetic process" EXACT [] +synonym: "maltose anabolism" EXACT [] +synonym: "maltose biosynthesis" EXACT [] +synonym: "maltose formation" EXACT [] +synonym: "maltose synthesis" EXACT [] +is_a: GO:0000023 ! maltose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0000025 +name: maltose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] +subset: gosubset_prok +synonym: "malt sugar catabolic process" EXACT [] +synonym: "malt sugar catabolism" EXACT [] +synonym: "maltose breakdown" EXACT [] +synonym: "maltose degradation" EXACT [] +synonym: "maltose hydrolysis" NARROW [] +xref: MetaCyc:MALTOSECAT-PWY +is_a: GO:0000023 ! maltose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0000026 +name: alpha-1,2-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541] +xref: EC:2.4.1.- +is_a: GO:0000030 ! mannosyltransferase activity +[Term] +id: GO:0000027 +name: ribosomal large subunit assembly and maintenance +namespace: biological_process +def: "The aggregation and bonding together of constituent RNAs and proteins to form and maintain the large ribosomal subunit." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042257 ! ribosomal subunit assembly +relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis and assembly +[Term] +id: GO:0000028 +name: ribosomal small subunit assembly and maintenance +namespace: biological_process +def: "The aggregation and bonding together of constituent RNAs and proteins to form and maintain the small ribosomal subunit." [GOC:jl] +subset: gosubset_prok +is_a: GO:0042257 ! ribosomal subunit assembly +relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis and assembly + +[Other] +id: 12 +name: something else +[Typedef] +id: part_of +name: part of +is_transitive: true +[Term] +id: GO:0000030 +name: mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +subset: gosubset_prok +xref: EC:2.4.1.- +xref: Reactome:7672 +is_a: GO:0016758 ! transferase activity, transferring hexosyl groups + + + + + + + + + + + + + + + + + + + + + diff --git a/forester/test_data/paup_log_test_1 b/forester/test_data/paup_log_test_1 new file mode 100644 index 0000000..8bc6b5f --- /dev/null +++ b/forester/test_data/paup_log_test_1 @@ -0,0 +1,119 @@ +P A U P * +Version 4.0b10 for 32-bit Microsoft Windows +Fri Mar 21 18:53:11 2008 + + -----------------------------NOTICE----------------------------- + This is a beta-test version. Please report any crashes, + apparent calculation errors, or other anomalous results. + There are no restrictions on publication of results obtained + with this version, but you should check the WWW site + frequently for bug announcements and/or updated versions. + See the README file on the distribution media for details. + ---------------------------------------------------------------- + +Tree description: + + Unrooted tree(s) rooted using outgroup method + Optimality criterion = parsimony + Character-status summary: + Of 4978 total characters: + All characters are of type 'unord' + All characters have equal weight + 419 characters are constant + 3179 variable characters are parsimony-uninformative + Number of parsimony-informative characters = 1380 + Character-state optimization: Accelerated transformation (ACCTRAN) + +Tree number 1 (rooted using default outgroup) + +Data matrix and reconstructed states for internal nodes: + + 111111111122222222223333333333444444444455555555556666666 +Taxon/Node 123456789012345678901234567890123456789012345678901234567890123456 +------------------------------------------------------------------------------ +MOUSE 000001111101100010110110001010111111110001111001001110101110001111 +NEMVE 000001111000000000010100001000000000100001011110110001110101110111 +MONBE 000001100001000100010001011111100000000001011000000000000000000100 +DICDI 111101100000011001010100001000000000001110011000000000000000000000 +ARATH 000011100010000001011000101010100000001000011000000000000000000000 +6 000001100000000001010000001010100000001000011000000000000000000000 +7 000001100000000000010000001010100000000001011000000000000000000100 +8 000001111000000000010100001010100000100001011000000000100100000111 + +Data matrix and reconstructed states for internal nodes (continued): + + + 444444444444444444444444444444444444444444444444444444444444444444 + 888888888888888999999999999999999999999999999999999999999999999999 + 888889999999999000000000011111111112222222222333333333344444444445 +Taxon/Node 567890123456789012345678901234567890123456789012345678901234567890 +------------------------------------------------------------------------------ +MOUSE 111110110111001001011110100001111101011101011011100111101011111100 +NEMVE 111100100110000001011110101110011100100001111000010001101011011100 +MONBE 011110100100000111011110000000011000000000010100000000101110001000 +DICDI 000101101100010001100010010000011100010011010000000000101010000000 +ARATH 010101101100100011111111001110011110000000010000001000110010000011 +6 010101101100000011111110000000011100000000010000000000101010000000 +7 011100100100000011011110000000011100000000010000000000101010001000 +8 111100100110000001011110100000011100000001011000000001101011011100 + +Data matrix and reconstructed states for internal nodes (continued): + + 4444444444444444444444444444 + 9999999999999999999999999999 + 5555555556666666666777777777 +Taxon/Node 1234567890123456789012345678 +---------------------------------------- +MOUSE 1100111010111111101011011110 +NEMVE 0100001000101101101000010010 +MONBE 1100001100001111000000001010 +DICDI 0110011000101100110001100001 +ARATH 0111111001001100110110001010 +6 0110011000001100110000001010 +7 0100001000001101100000001010 +8 0100001000101101101000011010 + +Tree length = 5111 +Consistency index (CI) = 0.8920 +Homoplasy index (HI) = 0.1080 +CI excluding uninformative characters = 0.7143 +HI excluding uninformative characters = 0.2857 +Retention index (RI) = 0.6000 +Rescaled consistency index (RC) = 0.5352 + +/------------------------------------------------------------ MOUSE +| ++--------------- NEMVE +8 +| /---------------------------- MONBE +| | +\------------------------------7 /---------------------- DICDI + \---------6 + \------------------------------ ARATH + +/----------------------------------------------------------------------- MOUSE +| ++----------------------------------------------------------------------- NEMVE +8 +| /----------------------------------------------- MONBE +| | +\-----------------------7 /------------------------ DICDI + \----------------------6 + \------------------------ ARATH + +Character change lists: + +Character CI Steps Changes +------------------------------------------------------------------------------ +1 (14-3-3=BRCT) 1.000 1 node_6 0 ==> 1 DICDI +2 (14-3-3=PARP) 1.000 1 node_6 0 ==> 1 DICDI +3 (14-3-3=VIT) 1.000 1 node_6 0 ==> 1 DICDI +4 (14-3-3=VWA) 1.000 1 node_6 0 ==> 1 DICDI +5 (2-Hacid_dh_C=ACT) 1.000 1 node_6 0 ==> 1 ARATH +8 (2OG-FeII_Oxy=Methyltransf_11) 1.000 1 node_8 1 ==> 0 node_7 +9 (2OG-FeII_Oxy=P4Ha_N) 1.000 1 node_8 1 ==> 0 node_7 +10 (2OG-FeII_Oxy=RRM_1) 1.000 1 node_8 0 ==> 1 MOUSE +11 (2OG-FeII_Oxy=ShK) 1.000 1 node_6 0 ==> 1 ARATH +12 (2OG-FeII_Oxy=TPR_2) 0.500 1 node_8 0 --> 1 MOUSE + 1 node_7 0 --> 1 MONBE + diff --git a/forester/test_data/pfam_to_go_test b/forester/test_data/pfam_to_go_test new file mode 100644 index 0000000..e264422 --- /dev/null +++ b/forester/test_data/pfam_to_go_test @@ -0,0 +1,434 @@ +!date: 2007/10/03 17:10:37 +!Mapping of Pfam entries to GO +!http://www.sanger.ac.uk/Software/Pfam/index.shtml +!Uses Interpro2Go by Nicola Mulder, Hinxton +! +Pfam:PF00001 7tm_1 > GO:rhodopsin-like receptor activity ; GO:0001584 + +Pfam:PF00001 7tm_1 > GO:G-protein coupled receptor protein signaling pathway ; GO:0007186 + + +Pfam:PF00001 7tm_1>GO:integral to membrane;GO:0016021 +Pfam:PF00002 7tm_2 > GO:G-protein coupled receptor activity ; GO:0004930 +Pfam:PF00002 7tm_2 > GO:membrane ; GO:0016020 +Pfam:PF00003 7tm_3 > GO:metabotropic glutamate, GABA-B-like receptor activity ; GO:0008067 +Pfam:PF00003 7tm_3 > GO:membrane ; GO:0016020 +Pfam:PF00004 AAA > GO:ATP binding ; GO:0005524 +Pfam:PF00005 ABC_tran > GO:ATP binding ; GO:0005524 +Pfam:PF00005 ABC_tran > GO:ATPase activity ; GO:0016887 +Pfam:PF00006 ATP-synt_ab > GO:ATP binding ; GO:0005524 +Pfam:PF00006 ATP-synt_ab > GO:hydrogen ion transporting ATP synthase activity, rotational mechanism ; GO:0046933 +Pfam:PF00006 ATP-synt_ab > GO:hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961 +Pfam:PF00006 ATP-synt_ab > GO:ATP synthesis coupled proton transport ; GO:0015986 +Pfam:PF00006 ATP-synt_ab > GO:proton-transporting two-sector ATPase complex ; GO:0016469 +Pfam:PF00009 GTP_EFTU > GO:GTPase activity ; GO:0003924 +Pfam:PF00009 GTP_EFTU > GO:GTP binding ; GO:0005525 +Pfam:PF00010 HLH > GO:transcription regulator activity ; GO:0030528 +Pfam:PF00010 HLH > GO:regulation of transcription ; GO:0045449 +Pfam:PF00010 HLH > GO:nucleus ; GO:0005634 +Pfam:PF00013 KH_1 > GO:RNA binding ; GO:0003723 +Pfam:PF00014 Kunitz_BPTI > GO:serine-type endopeptidase inhibitor activity ; GO:0004867 +Pfam:PF00015 MCPsignal > GO:signal transducer activity ; GO:0004871 +Pfam:PF00015 MCPsignal > GO:chemotaxis ; GO:0006935 +Pfam:PF00015 MCPsignal > GO:signal transduction ; GO:0007165 +Pfam:PF00015 MCPsignal > GO:membrane ; GO:0016020 +Pfam:PF00016 RuBisCO_large > GO:ribulose-bisphosphate carboxylase activity ; GO:0016984 +Pfam:PF00016 RuBisCO_large > GO:carbon utilization by fixation of carbon dioxide ; GO:0015977 +Pfam:PF00016 RuBisCO_large > GO:chloroplast ribulose bisphosphate carboxylase complex ; GO:0009573 +Pfam:PF00017 SH2 > GO:intracellular signaling cascade ; GO:0007242 +Pfam:PF00019 TGF_beta > GO:growth factor activity ; GO:0008083 +Pfam:PF00020 TNFR_c6 > GO:receptor activity ; GO:0004872 +Pfam:PF00022 Actin > GO:protein binding ; GO:0005515 +Pfam:PF00025 Arf > GO:GTP binding ; GO:0005525 +Pfam:PF00026 Asp > GO:pepsin A activity ; GO:0004194 +Pfam:PF00026 Asp > GO:proteolysis ; GO:0006508 +Pfam:PF00028 Cadherin > GO:calcium ion binding ; GO:0005509 +Pfam:PF00028 Cadherin > GO:homophilic cell adhesion ; GO:0007156 +Pfam:PF00028 Cadherin > GO:membrane ; GO:0016020 +Pfam:PF00031 Cystatin > GO:cysteine protease inhibitor activity ; GO:0004869 +Pfam:PF00032 Cytochrom_B_C > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00032 Cytochrom_B_C > GO:electron transport ; GO:0006118 +Pfam:PF00032 Cytochrom_B_C > GO:membrane ; GO:0016020 +Pfam:PF00033 Cytochrom_B_N > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00033 Cytochrom_B_N > GO:electron transport ; GO:0006118 +Pfam:PF00033 Cytochrom_B_N > GO:membrane ; GO:0016020 +Pfam:PF00034 Cytochrom_C > GO:iron ion binding ; GO:0005506 +Pfam:PF00034 Cytochrom_C > GO:electron carrier activity ; GO:0009055 +Pfam:PF00034 Cytochrom_C > GO:heme binding ; GO:0020037 +Pfam:PF00034 Cytochrom_C > GO:electron transport ; GO:0006118 +Pfam:PF00035 dsrm > GO:double-stranded RNA binding ; GO:0003725 +Pfam:PF00035 dsrm > GO:intracellular ; GO:0005622 +Pfam:PF00036 efhand > GO:calcium ion binding ; GO:0005509 +Pfam:PF00037 Fer4 > GO:electron carrier activity ; GO:0009055 +Pfam:PF00037 Fer4 > GO:iron-sulfur cluster binding ; GO:0051536 +Pfam:PF00037 Fer4 > GO:electron transport ; GO:0006118 +Pfam:PF00038 Filament > GO:structural molecule activity ; GO:0005198 +Pfam:PF00039 fn1 > GO:extracellular region ; GO:0005576 +Pfam:PF00042 Globin > GO:iron ion binding ; GO:0005506 +Pfam:PF00042 Globin > GO:oxygen binding ; GO:0019825 +Pfam:PF00042 Globin > GO:heme binding ; GO:0020037 +Pfam:PF00042 Globin > GO:oxygen transport ; GO:0015671 +Pfam:PF00044 Gp_dh_N > GO:glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity ; GO:0004365 +Pfam:PF00044 Gp_dh_N > GO:NAD binding ; GO:0051287 +Pfam:PF00044 Gp_dh_N > GO:glycolysis ; GO:0006096 +Pfam:PF00045 Hemopexin > GO:catalytic activity ; GO:0003824 +Pfam:PF00045 Hemopexin > GO:metal ion binding ; GO:0046872 +Pfam:PF00046 Homeobox > GO:transcription factor activity ; GO:0003700 +Pfam:PF00046 Homeobox > GO:sequence-specific DNA binding ; GO:0043565 +Pfam:PF00046 Homeobox > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00046 Homeobox > GO:nucleus ; GO:0005634 +Pfam:PF00048 IL8 > GO:chemokine activity ; GO:0008009 +Pfam:PF00048 IL8 > GO:immune response ; GO:0006955 +Pfam:PF00048 IL8 > GO:extracellular region ; GO:0005576 +Pfam:PF00049 Insulin > GO:hormone activity ; GO:0005179 +Pfam:PF00049 Insulin > GO:extracellular region ; GO:0005576 +Pfam:PF00052 Laminin_B > GO:cell adhesion ; GO:0007155 +Pfam:PF00052 Laminin_B > GO:extracellular matrix ; GO:0031012 +Pfam:PF00055 Laminin_N > GO:proteinaceous extracellular matrix ; GO:0005578 +Pfam:PF00056 Ldh_1_N > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00056 Ldh_1_N > GO:tricarboxylic acid cycle intermediate metabolic process ; GO:0006100 +Pfam:PF00058 Ldl_recept_b > GO:membrane ; GO:0016020 +Pfam:PF00059 Lectin_C > GO:sugar binding ; GO:0005529 +Pfam:PF00060 Lig_chan > GO:ionotropic glutamate receptor activity ; GO:0004970 +Pfam:PF00060 Lig_chan > GO:extracellular-glutamate-gated ion channel activity ; GO:0005234 +Pfam:PF00060 Lig_chan > GO:membrane ; GO:0016020 +Pfam:PF00061 Lipocalin > GO:binding ; GO:0005488 +Pfam:PF00062 Lys > GO:extracellular region ; GO:0005576 +Pfam:PF00063 Myosin_head > GO:motor activity ; GO:0003774 +Pfam:PF00063 Myosin_head > GO:ATP binding ; GO:0005524 +Pfam:PF00063 Myosin_head > GO:myosin complex ; GO:0016459 +Pfam:PF00064 Neur > GO:exo-alpha-sialidase activity ; GO:0004308 +Pfam:PF00064 Neur > GO:carbohydrate metabolic process ; GO:0005975 +Pfam:PF00064 Neur > GO:membrane ; GO:0016020 +Pfam:PF00066 Notch > GO:cell differentiation ; GO:0030154 +Pfam:PF00066 Notch > GO:membrane ; GO:0016020 +Pfam:PF00067 p450 > GO:monooxygenase activity ; GO:0004497 +Pfam:PF00067 p450 > GO:iron ion binding ; GO:0005506 +Pfam:PF00067 p450 > GO:heme binding ; GO:0020037 +Pfam:PF00067 p450 > GO:electron transport ; GO:0006118 +Pfam:PF00068 Phospholip_A2_1 > GO:phospholipase A2 activity ; GO:0004623 +Pfam:PF00068 Phospholip_A2_1 > GO:calcium ion binding ; GO:0005509 +Pfam:PF00068 Phospholip_A2_1 > GO:lipid catabolic process ; GO:0016042 +Pfam:PF00069 Pkinase > GO:protein kinase activity ; GO:0004672 +Pfam:PF00069 Pkinase > GO:ATP binding ; GO:0005524 +Pfam:PF00069 Pkinase > GO:protein amino acid phosphorylation ; GO:0006468 +Pfam:PF00070 Pyr_redox > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00070 Pyr_redox > GO:FAD binding ; GO:0050660 +Pfam:PF00072 Response_reg > GO:two-component response regulator activity ; GO:0000156 +Pfam:PF00072 Response_reg > GO:two-component signal transduction system (phosphorelay) ; GO:0000160 +Pfam:PF00072 Response_reg > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00073 Rhv > GO:structural molecule activity ; GO:0005198 +Pfam:PF00073 Rhv > GO:viral capsid ; GO:0019028 +Pfam:PF00074 RnaseA > GO:nucleic acid binding ; GO:0003676 +Pfam:PF00074 RnaseA > GO:pancreatic ribonuclease activity ; GO:0004522 +Pfam:PF00075 RnaseH > GO:nucleic acid binding ; GO:0003676 +Pfam:PF00075 RnaseH > GO:ribonuclease H activity ; GO:0004523 +Pfam:PF00076 RRM_1 > GO:nucleic acid binding ; GO:0003676 +Pfam:PF00077 RVP > GO:aspartic-type endopeptidase activity ; GO:0004190 +Pfam:PF00077 RVP > GO:proteolysis ; GO:0006508 +Pfam:PF00078 RVT_1 > GO:RNA binding ; GO:0003723 +Pfam:PF00078 RVT_1 > GO:RNA-directed DNA polymerase activity ; GO:0003964 +Pfam:PF00078 RVT_1 > GO:RNA-dependent DNA replication ; GO:0006278 +Pfam:PF00079 Serpin > GO:serine-type endopeptidase inhibitor activity ; GO:0004867 +Pfam:PF00080 Sod_Cu > GO:copper, zinc superoxide dismutase activity ; GO:0004785 +Pfam:PF00080 Sod_Cu > GO:metal ion binding ; GO:0046872 +Pfam:PF00080 Sod_Cu > GO:superoxide metabolic process ; GO:0006801 +Pfam:PF00081 Sod_Fe_N > GO:superoxide dismutase activity ; GO:0004784 +Pfam:PF00081 Sod_Fe_N > GO:metal ion binding ; GO:0046872 +Pfam:PF00081 Sod_Fe_N > GO:superoxide metabolic process ; GO:0006801 +Pfam:PF00082 Peptidase_S8 > GO:subtilase activity ; GO:0004289 +Pfam:PF00082 Peptidase_S8 > GO:proteolysis ; GO:0006508 +Pfam:PF00083 Sugar_tr > GO:transporter activity ; GO:0005215 +Pfam:PF00083 Sugar_tr > GO:transport ; GO:0006810 +Pfam:PF00083 Sugar_tr > GO:integral to membrane ; GO:0016021 +Pfam:PF00087 Toxin_1 > GO:pathogenesis ; GO:0009405 +Pfam:PF00087 Toxin_1 > GO:extracellular region ; GO:0005576 +Pfam:PF00089 Trypsin > GO:serine-type endopeptidase activity ; GO:0004252 +Pfam:PF00089 Trypsin > GO:proteolysis ; GO:0006508 +Pfam:PF00095 WAP > GO:protease inhibitor activity ; GO:0030414 +Pfam:PF00096 zf-C2H2 > GO:nucleic acid binding ; GO:0003676 +Pfam:PF00096 zf-C2H2 > GO:zinc ion binding ; GO:0008270 +Pfam:PF00096 zf-C2H2 > GO:intracellular ; GO:0005622 +Pfam:PF00097 zf-C3HC4 > GO:protein binding ; GO:0005515 +Pfam:PF00097 zf-C3HC4 > GO:zinc ion binding ; GO:0008270 +Pfam:PF00098 zf-CCHC > GO:nucleic acid binding ; GO:0003676 +Pfam:PF00098 zf-CCHC > GO:zinc ion binding ; GO:0008270 +Pfam:PF00101 RuBisCO_small > GO:ribulose-bisphosphate carboxylase activity ; GO:0016984 +Pfam:PF00101 RuBisCO_small > GO:carbon utilization by fixation of carbon dioxide ; GO:0015977 +Pfam:PF00101 RuBisCO_small > GO:chloroplast ribulose bisphosphate carboxylase complex ; GO:0009573 +Pfam:PF00102 Y_phosphatase > GO:protein tyrosine phosphatase activity ; GO:0004725 +Pfam:PF00102 Y_phosphatase > GO:protein amino acid dephosphorylation ; GO:0006470 +Pfam:PF00103 Hormone_1 > GO:hormone activity ; GO:0005179 +Pfam:PF00103 Hormone_1 > GO:extracellular region ; GO:0005576 +Pfam:PF00104 Hormone_recep > GO:transcription factor activity ; GO:0003700 +Pfam:PF00104 Hormone_recep > GO:steroid hormone receptor activity ; GO:0003707 +Pfam:PF00104 Hormone_recep > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00104 Hormone_recep > GO:nucleus ; GO:0005634 +Pfam:PF00105 zf-C4 > GO:transcription factor activity ; GO:0003700 +Pfam:PF00105 zf-C4 > GO:zinc ion binding ; GO:0008270 +Pfam:PF00105 zf-C4 > GO:sequence-specific DNA binding ; GO:0043565 +Pfam:PF00105 zf-C4 > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00105 zf-C4 > GO:nucleus ; GO:0005634 +Pfam:PF00106 adh_short > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00106 adh_short > GO:metabolic process ; GO:0008152 +Pfam:PF00110 wnt > GO:signal transducer activity ; GO:0004871 +Pfam:PF00110 wnt > GO:Wnt receptor signaling pathway, calcium modulating pathway ; GO:0007223 +Pfam:PF00110 wnt > GO:multicellular organismal development ; GO:0007275 +Pfam:PF00110 wnt > GO:extracellular region ; GO:0005576 +Pfam:PF00111 Fer2 > GO:electron carrier activity ; GO:0009055 +Pfam:PF00111 Fer2 > GO:iron-sulfur cluster binding ; GO:0051536 +Pfam:PF00111 Fer2 > GO:electron transport ; GO:0006118 +Pfam:PF00112 Peptidase_C1 > GO:cysteine-type peptidase activity ; GO:0008234 +Pfam:PF00112 Peptidase_C1 > GO:proteolysis ; GO:0006508 +Pfam:PF00113 Enolase_C > GO:phosphopyruvate hydratase activity ; GO:0004634 +Pfam:PF00113 Enolase_C > GO:glycolysis ; GO:0006096 +Pfam:PF00113 Enolase_C > GO:phosphopyruvate hydratase complex ; GO:0000015 +Pfam:PF00114 Pilin > GO:cell adhesion ; GO:0007155 +Pfam:PF00114 Pilin > GO:fimbrium ; GO:0009289 +Pfam:PF00115 COX1 > GO:iron ion binding ; GO:0005506 +Pfam:PF00115 COX1 > GO:heme binding ; GO:0020037 +Pfam:PF00115 COX1 > GO:electron transport ; GO:0006118 +Pfam:PF00115 COX1 > GO:aerobic respiration ; GO:0009060 +Pfam:PF00115 COX1 > GO:integral to membrane ; GO:0016021 +Pfam:PF00116 COX2 > GO:cytochrome-c oxidase activity ; GO:0004129 +Pfam:PF00116 COX2 > GO:copper ion binding ; GO:0005507 +Pfam:PF00116 COX2 > GO:electron transport ; GO:0006118 +Pfam:PF00116 COX2 > GO:membrane ; GO:0016020 +Pfam:PF00117 GATase > GO:catalytic activity ; GO:0003824 +Pfam:PF00118 Cpn60_TCP1 > GO:protein binding ; GO:0005515 +Pfam:PF00118 Cpn60_TCP1 > GO:ATP binding ; GO:0005524 +Pfam:PF00118 Cpn60_TCP1 > GO:cellular protein metabolic process ; GO:0044267 +Pfam:PF00119 ATP-synt_A > GO:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ; GO:0016820 +Pfam:PF00119 ATP-synt_A > GO:proton transport ; GO:0015992 +Pfam:PF00119 ATP-synt_A > GO:membrane ; GO:0016020 +Pfam:PF00119 ATP-synt_A > GO:proton-transporting two-sector ATPase complex ; GO:0016469 +Pfam:PF00120 Gln-synt_C > GO:glutamate-ammonia ligase activity ; GO:0004356 +Pfam:PF00120 Gln-synt_C > GO:nitrogen compound metabolic process ; GO:0006807 +Pfam:PF00121 TIM > GO:triose-phosphate isomerase activity ; GO:0004807 +Pfam:PF00121 TIM > GO:metabolic process ; GO:0008152 +Pfam:PF00122 E1-E2_ATPase > GO:ATP binding ; GO:0005524 +Pfam:PF00122 E1-E2_ATPase > GO:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ; GO:0016820 +Pfam:PF00122 E1-E2_ATPase > GO:membrane ; GO:0016020 +Pfam:PF00123 Hormone_2 > GO:hormone activity ; GO:0005179 +Pfam:PF00123 Hormone_2 > GO:extracellular region ; GO:0005576 +Pfam:PF00124 Photo_RC > GO:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity ; GO:0045156 +Pfam:PF00124 Photo_RC > GO:electron transport ; GO:0006118 +Pfam:PF00124 Photo_RC > GO:photosynthesis, light reaction ; GO:0019684 +Pfam:PF00124 Photo_RC > GO:plasma membrane light-harvesting complex ; GO:0030077 +Pfam:PF00125 Histone > GO:DNA binding ; GO:0003677 +Pfam:PF00126 HTH_1 > GO:transcription factor activity ; GO:0003700 +Pfam:PF00126 HTH_1 > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00127 Copper-bind > GO:copper ion binding ; GO:0005507 +Pfam:PF00127 Copper-bind > GO:electron carrier activity ; GO:0009055 +Pfam:PF00127 Copper-bind > GO:electron transport ; GO:0006118 +Pfam:PF00128 Alpha-amylase > GO:catalytic activity ; GO:0003824 +Pfam:PF00128 Alpha-amylase > GO:cation binding ; GO:0043169 +Pfam:PF00128 Alpha-amylase > GO:carbohydrate metabolic process ; GO:0005975 +Pfam:PF00129 MHC_I > GO:immune response ; GO:0006955 +Pfam:PF00129 MHC_I > GO:antigen processing and presentation ; GO:0019882 +Pfam:PF00129 MHC_I > GO:membrane ; GO:0016020 +Pfam:PF00129 MHC_I > GO:MHC class I protein complex ; GO:0042612 +Pfam:PF00130 C1_1 > GO:intracellular signaling cascade ; GO:0007242 +Pfam:PF00131 Metallothio > GO:metal ion binding ; GO:0046872 +Pfam:PF00132 Hexapep > GO:acyltransferase activity ; GO:0008415 +Pfam:PF00133 tRNA-synt_1 > GO:nucleotide binding ; GO:0000166 +Pfam:PF00133 tRNA-synt_1 > GO:aminoacyl-tRNA ligase activity ; GO:0004812 +Pfam:PF00133 tRNA-synt_1 > GO:ATP binding ; GO:0005524 +Pfam:PF00133 tRNA-synt_1 > GO:translation ; GO:0006412 +Pfam:PF00133 tRNA-synt_1 > GO:tRNA aminoacylation for protein translation ; GO:0006418 +Pfam:PF00133 tRNA-synt_1 > GO:cytoplasm ; GO:0005737 +Pfam:PF00134 Cyclin_N > GO:regulation of progression through cell cycle ; GO:0000074 +Pfam:PF00136 DNA_pol_B > GO:nucleotide binding ; GO:0000166 +Pfam:PF00136 DNA_pol_B > GO:DNA binding ; GO:0003677 +Pfam:PF00136 DNA_pol_B > GO:DNA-directed DNA polymerase activity ; GO:0003887 +Pfam:PF00136 DNA_pol_B > GO:DNA replication ; GO:0006260 +Pfam:PF00137 ATP-synt_C > GO:hydrogen ion transporting ATP synthase activity, rotational mechanism ; GO:0046933 +Pfam:PF00137 ATP-synt_C > GO:hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961 +Pfam:PF00137 ATP-synt_C > GO:ATP synthesis coupled proton transport ; GO:0015986 +Pfam:PF00137 ATP-synt_C > GO:membrane ; GO:0016020 +Pfam:PF00137 ATP-synt_C > GO:proton-transporting two-sector ATPase complex ; GO:0016469 +Pfam:PF00139 Lectin_legB > GO:sugar binding ; GO:0005529 +Pfam:PF00140 Sigma70_r1_2 > GO:DNA binding ; GO:0003677 +Pfam:PF00140 Sigma70_r1_2 > GO:transcription factor activity ; GO:0003700 +Pfam:PF00140 Sigma70_r1_2 > GO:sigma factor activity ; GO:0016987 +Pfam:PF00140 Sigma70_r1_2 > GO:transcription initiation ; GO:0006352 +Pfam:PF00140 Sigma70_r1_2 > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00141 peroxidase > GO:peroxidase activity ; GO:0004601 +Pfam:PF00141 peroxidase > GO:heme binding ; GO:0020037 +Pfam:PF00141 peroxidase > GO:electron transport ; GO:0006118 +Pfam:PF00141 peroxidase > GO:response to oxidative stress ; GO:0006979 +Pfam:PF00142 Fer4_NifH > GO:ATP binding ; GO:0005524 +Pfam:PF00142 Fer4_NifH > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00142 Fer4_NifH > GO:electron transport ; GO:0006118 +Pfam:PF00143 Interferon > GO:hematopoietin/interferon-class (D200-domain) cytokine receptor binding ; GO:0005126 +Pfam:PF00143 Interferon > GO:defense response ; GO:0006952 +Pfam:PF00143 Interferon > GO:extracellular region ; GO:0005576 +Pfam:PF00144 Beta-lactamase > GO:beta-lactamase activity ; GO:0008800 +Pfam:PF00144 Beta-lactamase > GO:beta-lactam antibiotic catabolic process ; GO:0030655 +Pfam:PF00144 Beta-lactamase > GO:response to antibiotic ; GO:0046677 +Pfam:PF00145 DNA_methylase > GO:DNA binding ; GO:0003677 +Pfam:PF00145 DNA_methylase > GO:DNA methylation ; GO:0006306 +Pfam:PF00146 NADHdh > GO:electron transport ; GO:0006118 +Pfam:PF00146 NADHdh > GO:membrane ; GO:0016020 +Pfam:PF00147 Fibrinogen_C > GO:receptor binding ; GO:0005102 +Pfam:PF00147 Fibrinogen_C > GO:signal transduction ; GO:0007165 +Pfam:PF00148 Oxidored_nitro > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00148 Oxidored_nitro > GO:electron transport ; GO:0006118 +Pfam:PF00149 Metallophos > GO:hydrolase activity ; GO:0016787 +Pfam:PF00150 Cellulase > GO:hydrolase activity, hydrolyzing O-glycosyl compounds ; GO:0004553 +Pfam:PF00150 Cellulase > GO:carbohydrate metabolic process ; GO:0005975 +Pfam:PF00152 tRNA-synt_2 > GO:nucleotide binding ; GO:0000166 +Pfam:PF00152 tRNA-synt_2 > GO:aminoacyl-tRNA ligase activity ; GO:0004812 +Pfam:PF00152 tRNA-synt_2 > GO:ATP binding ; GO:0005524 +Pfam:PF00152 tRNA-synt_2 > GO:translation ; GO:0006412 +Pfam:PF00152 tRNA-synt_2 > GO:tRNA aminoacylation for protein translation ; GO:0006418 +Pfam:PF00152 tRNA-synt_2 > GO:cytoplasm ; GO:0005737 +Pfam:PF00153 Mito_carr > GO:binding ; GO:0005488 +Pfam:PF00153 Mito_carr > GO:transport ; GO:0006810 +Pfam:PF00153 Mito_carr > GO:membrane ; GO:0016020 +Pfam:PF00155 Aminotran_1_2 > GO:transferase activity, transferring nitrogenous groups ; GO:0016769 +Pfam:PF00155 Aminotran_1_2 > GO:pyridoxal phosphate binding ; GO:0030170 +Pfam:PF00155 Aminotran_1_2 > GO:biosynthetic process ; GO:0009058 +Pfam:PF00156 Pribosyltran > GO:nucleoside metabolic process ; GO:0009116 +Pfam:PF00157 Pou > GO:transcription factor activity ; GO:0003700 +Pfam:PF00157 Pou > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00157 Pou > GO:nucleus ; GO:0005634 +Pfam:PF00158 Sigma54_activat > GO:ATP binding ; GO:0005524 +Pfam:PF00158 Sigma54_activat > GO:transcription factor binding ; GO:0008134 +Pfam:PF00158 Sigma54_activat > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00158 Sigma54_activat > GO:intracellular ; GO:0005622 +Pfam:PF00159 Hormone_3 > GO:hormone activity ; GO:0005179 +Pfam:PF00159 Hormone_3 > GO:extracellular region ; GO:0005576 +Pfam:PF00160 Pro_isomerase > GO:peptidyl-prolyl cis-trans isomerase activity ; GO:0003755 +Pfam:PF00160 Pro_isomerase > GO:protein folding ; GO:0006457 +Pfam:PF00161 RIP > GO:rRNA N-glycosylase activity ; GO:0030598 +Pfam:PF00161 RIP > GO:negative regulation of protein biosynthetic process ; GO:0017148 +Pfam:PF00162 PGK > GO:phosphoglycerate kinase activity ; GO:0004618 +Pfam:PF00162 PGK > GO:glycolysis ; GO:0006096 +Pfam:PF00163 Ribosomal_S4 > GO:rRNA binding ; GO:0019843 +Pfam:PF00163 Ribosomal_S4 > GO:translation ; GO:0006412 +Pfam:PF00163 Ribosomal_S4 > GO:intracellular ; GO:0005622 +Pfam:PF00163 Ribosomal_S4 > GO:ribonucleoprotein complex ; GO:0030529 +Pfam:PF00164 Ribosomal_S12 > GO:structural constituent of ribosome ; GO:0003735 +Pfam:PF00164 Ribosomal_S12 > GO:translation ; GO:0006412 +Pfam:PF00164 Ribosomal_S12 > GO:intracellular ; GO:0005622 +Pfam:PF00164 Ribosomal_S12 > GO:ribosome ; GO:0005840 +Pfam:PF00165 HTH_AraC > GO:transcription factor activity ; GO:0003700 +Pfam:PF00165 HTH_AraC > GO:sequence-specific DNA binding ; GO:0043565 +Pfam:PF00165 HTH_AraC > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00165 HTH_AraC > GO:intracellular ; GO:0005622 +Pfam:PF00166 Cpn10 > GO:ATP binding ; GO:0005524 +Pfam:PF00166 Cpn10 > GO:protein folding ; GO:0006457 +Pfam:PF00167 FGF > GO:growth factor activity ; GO:0008083 +Pfam:PF00170 bZIP_1 > GO:transcription factor activity ; GO:0003700 +Pfam:PF00170 bZIP_1 > GO:sequence-specific DNA binding ; GO:0043565 +Pfam:PF00170 bZIP_1 > GO:protein dimerization activity ; GO:0046983 +Pfam:PF00170 bZIP_1 > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00170 bZIP_1 > GO:nucleus ; GO:0005634 +Pfam:PF00171 Aldedh > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00171 Aldedh > GO:metabolic process ; GO:0008152 +Pfam:PF00172 Zn_clus > GO:transcription factor activity ; GO:0003700 +Pfam:PF00172 Zn_clus > GO:zinc ion binding ; GO:0008270 +Pfam:PF00172 Zn_clus > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00172 Zn_clus > GO:nucleus ; GO:0005634 +Pfam:PF00173 Cyt-b5 > GO:heme binding ; GO:0020037 +Pfam:PF00173 Cyt-b5 > GO:transition metal ion binding ; GO:0046914 +Pfam:PF00174 Oxidored_molyb > GO:electron transport ; GO:0006118 +Pfam:PF00175 NAD_binding_1 > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00175 NAD_binding_1 > GO:electron transport ; GO:0006118 +Pfam:PF00176 SNF2_N > GO:DNA binding ; GO:0003677 +Pfam:PF00176 SNF2_N > GO:ATP binding ; GO:0005524 +Pfam:PF00177 Ribosomal_S7 > GO:structural constituent of ribosome ; GO:0003735 +Pfam:PF00177 Ribosomal_S7 > GO:translation ; GO:0006412 +Pfam:PF00177 Ribosomal_S7 > GO:intracellular ; GO:0005622 +Pfam:PF00177 Ribosomal_S7 > GO:ribosome ; GO:0005840 +Pfam:PF00178 Ets > GO:transcription factor activity ; GO:0003700 +Pfam:PF00178 Ets > GO:sequence-specific DNA binding ; GO:0043565 +Pfam:PF00178 Ets > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00178 Ets > GO:nucleus ; GO:0005634 +Pfam:PF00179 UQ_con > GO:small conjugating protein ligase activity ; GO:0019787 +Pfam:PF00179 UQ_con > GO:protein modification process ; GO:0006464 +Pfam:PF00179 UQ_con > GO:ubiquitin cycle ; GO:0006512 +Pfam:PF00180 Iso_dh > GO:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; GO:0016616 +Pfam:PF00180 Iso_dh > GO:metabolic process ; GO:0008152 +Pfam:PF00181 Ribosomal_L2 > GO:structural constituent of ribosome ; GO:0003735 +Pfam:PF00181 Ribosomal_L2 > GO:translation ; GO:0006412 +Pfam:PF00181 Ribosomal_L2 > GO:intracellular ; GO:0005622 +Pfam:PF00181 Ribosomal_L2 > GO:ribosome ; GO:0005840 +Pfam:PF00182 Glyco_hydro_19 > GO:chitinase activity ; GO:0004568 +Pfam:PF00182 Glyco_hydro_19 > GO:chitin catabolic process ; GO:0006032 +Pfam:PF00182 Glyco_hydro_19 > GO:cell wall catabolic process ; GO:0016998 +Pfam:PF00183 HSP90 > GO:unfolded protein binding ; GO:0051082 +Pfam:PF00183 HSP90 > GO:protein folding ; GO:0006457 +Pfam:PF00184 Hormone_5 > GO:neurohypophyseal hormone activity ; GO:0005185 +Pfam:PF00184 Hormone_5 > GO:extracellular region ; GO:0005576 +Pfam:PF00185 OTCace > GO:amino acid binding ; GO:0016597 +Pfam:PF00185 OTCace > GO:carboxyl- or carbamoyltransferase activity ; GO:0016743 +Pfam:PF00185 OTCace > GO:amino acid metabolic process ; GO:0006520 +Pfam:PF00186 DHFR_1 > GO:dihydrofolate reductase activity ; GO:0004146 +Pfam:PF00186 DHFR_1 > GO:glycine biosynthetic process ; GO:0006545 +Pfam:PF00186 DHFR_1 > GO:nucleotide biosynthetic process ; GO:0009165 +Pfam:PF00187 Chitin_bind_1 > GO:chitin binding ; GO:0008061 +Pfam:PF00189 Ribosomal_S3_C > GO:structural constituent of ribosome ; GO:0003735 +Pfam:PF00189 Ribosomal_S3_C > GO:translation ; GO:0006412 +Pfam:PF00189 Ribosomal_S3_C > GO:intracellular ; GO:0005622 +Pfam:PF00189 Ribosomal_S3_C > GO:ribosome ; GO:0005840 +Pfam:PF00190 Cupin_1 > GO:nutrient reservoir activity ; GO:0045735 +Pfam:PF00191 Annexin > GO:calcium ion binding ; GO:0005509 +Pfam:PF00191 Annexin > GO:calcium-dependent phospholipid binding ; GO:0005544 +Pfam:PF00193 Xlink > GO:hyaluronic acid binding ; GO:0005540 +Pfam:PF00193 Xlink > GO:cell adhesion ; GO:0007155 +Pfam:PF00194 Carb_anhydrase > GO:carbonate dehydratase activity ; GO:0004089 +Pfam:PF00194 Carb_anhydrase > GO:zinc ion binding ; GO:0008270 +Pfam:PF00194 Carb_anhydrase > GO:one-carbon compound metabolic process ; GO:0006730 +Pfam:PF00195 Chal_sti_synt_N > GO:acyltransferase activity ; GO:0008415 +Pfam:PF00195 Chal_sti_synt_N > GO:biosynthetic process ; GO:0009058 +Pfam:PF00196 GerE > GO:transcription factor activity ; GO:0003700 +Pfam:PF00196 GerE > GO:sequence-specific DNA binding ; GO:0043565 +Pfam:PF00196 GerE > GO:regulation of transcription, DNA-dependent ; GO:0006355 +Pfam:PF00196 GerE > GO:intracellular ; GO:0005622 +Pfam:PF00197 Kunitz_legume > GO:endopeptidase inhibitor activity ; GO:0004866 +Pfam:PF00198 2-oxoacid_dh > GO:acyltransferase activity ; GO:0008415 +Pfam:PF00198 2-oxoacid_dh > GO:metabolic process ; GO:0008152 +Pfam:PF00199 Catalase > GO:catalase activity ; GO:0004096 +Pfam:PF00199 Catalase > GO:electron transport ; GO:0006118 +Pfam:PF00199 Catalase > GO:response to oxidative stress ; GO:0006979 +Pfam:PF00201 UDPGT > GO:transferase activity, transferring hexosyl groups ; GO:0016758 +Pfam:PF00201 UDPGT > GO:metabolic process ; GO:0008152 +Pfam:PF00202 Aminotran_3 > GO:transaminase activity ; GO:0008483 +Pfam:PF00202 Aminotran_3 > GO:pyridoxal phosphate binding ; GO:0030170 +Pfam:PF00203 Ribosomal_S19 > GO:structural constituent of ribosome ; GO:0003735 +Pfam:PF00203 Ribosomal_S19 > GO:translation ; GO:0006412 +Pfam:PF00203 Ribosomal_S19 > GO:intracellular ; GO:0005622 +Pfam:PF00203 Ribosomal_S19 > GO:ribosome ; GO:0005840 +Pfam:PF00204 DNA_gyraseB > GO:DNA binding ; GO:0003677 +Pfam:PF00204 DNA_gyraseB > GO:DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918 +Pfam:PF00204 DNA_gyraseB > GO:ATP binding ; GO:0005524 +Pfam:PF00204 DNA_gyraseB > GO:DNA topological change ; GO:0006265 +Pfam:PF00204 DNA_gyraseB > GO:chromosome ; GO:0005694 +Pfam:PF00205 TPP_enzyme_M > GO:magnesium ion binding ; GO:0000287 +Pfam:PF00205 TPP_enzyme_M > GO:thiamin pyrophosphate binding ; GO:0030976 +Pfam:PF00206 Lyase_1 > GO:catalytic activity ; GO:0003824 +Pfam:PF00207 A2M > GO:endopeptidase inhibitor activity ; GO:0004866 +Pfam:PF00208 ELFV_dehydrog > GO:oxidoreductase activity ; GO:0016491 +Pfam:PF00208 ELFV_dehydrog > GO:amino acid metabolic process ; GO:0006520 +Pfam:PF00209 SNF > GO:neurotransmitter:sodium symporter activity ; GO:0005328 +Pfam:PF00209 SNF > GO:neurotransmitter transport ; GO:0006836 +Pfam:PF00209 SNF > GO:integral to plasma membrane ; GO:0005887 +Pfam:PF00209 SNF > GO:membrane ; GO:0016020 +Pfam:PF00210 Ferritin > GO:ferric iron binding ; GO:0008199 +Pfam:PF00210 Ferritin > GO:cellular iron ion homeostasis ; GO:0006879 +Pfam:PF00211 Guanylate_cyc > GO:phosphorus-oxygen lyase activity ; GO:0016849 +Pfam:PF00211 Guanylate_cyc > GO:intracellular signaling cascade ; GO:0007242 +Pfam:PF00211 Guanylate_cyc > GO:cyclic nucleotide biosynthetic process ; GO:0009190 +Pfam:PF00212 ANP > GO:hormone activity ; GO:0005179 +Pfam:PF00212 ANP > GO:extracellular region ; GO:0005576 +Pfam:PF00213 OSCP > GO:hydrogen ion transporting ATP synthase activity, rotational mechanism ; GO:0046933 +Pfam:PF00213 OSCP > GO:hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961 +Pfam:PF00213 OSCP > GO:ATP synthesis coupled proton transport ; GO:0015986 +Pfam:PF00213 OSCP > GO:proton-transporting two-sector ATPase complex ; GO:0016469 +Pfam:PF00214 Calc_CGRP_IAPP > GO:hormone activity ; GO:0005179 +Pfam:PF00214 Calc_CGRP_IAPP > GO:extracellular region ; GO:0005576 +Pfam:PF00215 OMPdecase > GO:orotidine-5'-phosphate decarboxylase activity ; GO:0004590 +Pfam:PF00215 OMPdecase > GO:'de novo' pyrimidine base biosynthetic process ; GO:0006207 +Pfam:PF00216 Bac_DNA_binding > GO:DNA binding ; GO:0003677 \ No newline at end of file diff --git a/forester/test_data/phylogeny27.nhx b/forester/test_data/phylogeny27.nhx new file mode 100644 index 0000000..41978be --- /dev/null +++ b/forester/test_data/phylogeny27.nhx @@ -0,0 +1 @@ +((((A,B)ab,C)abc,D)abcd,E)abcde diff --git a/forester/test_data/phylogeny28.nhx b/forester/test_data/phylogeny28.nhx new file mode 100644 index 0000000..39d8093 --- /dev/null +++ b/forester/test_data/phylogeny28.nhx @@ -0,0 +1,51 @@ + +; + +; ; ; + + +; + +( ( + + + +( ( A, + + + +B)ab,C)abc,D) a b c d,E) + +a + b +c +d + + + + + + + + +e + + + + + + ( A , ( B , ( C , ( + D , E ) d e ) c d e ) b + + + c d e ) +a b c d e + + + + + +;;; + + +(A,B)ab((((A,B),C),D),;E;) \ No newline at end of file diff --git a/forester/test_data/phyloxml_distribution.xml b/forester/test_data/phyloxml_distribution.xml new file mode 100644 index 0000000..4069534 --- /dev/null +++ b/forester/test_data/phyloxml_distribution.xml @@ -0,0 +1,102 @@ + + + + t3 + 1-1 + test of Distribution Element + + root node + + Hirschweg 38 + + 47.48148427110029 + 8.768951296806335 + 472 + + + + node a + + Nagoya, Aichi, Japan + + 35.155904 + 136.915863 + 10 + + + + San Diego + + 32.880933 + -117.217543 + 104 + + + + + + + Africa + + + + node bb + + + 1 + 2 + 10 + + + 3 + 4 + 20 + + + 5 + 6 + 30 + + + + 0.1 + 0.2 + 10 + + + 0.3 + 0.4 + 20 + + + 0.5 + 0.6 + 30 + + + + + 1.49348902489947473 + 2.567489393947847492 + 10 + + + 1.49348902489947473 + 2.567489393947847492 + 10 + + + 1.49348902489947473 + 2.567489393947847492 + 10 + + + + + + + + + diff --git a/forester/test_data/phyloxml_test_atv.xml b/forester/test_data/phyloxml_test_atv.xml new file mode 100644 index 0000000..47e3906 --- /dev/null +++ b/forester/test_data/phyloxml_test_atv.xml @@ -0,0 +1,142 @@ + + + + t3 + 1-1 + test phylogeny + 0.1 + + root node + 90 + 1e-3 + 2 + 10 + + 2 + 22 + 33 + + root id + + 1 + ECDYS + ecdysozoa + molting animals + phylum + http://www.ecdysozoa.org/ + + + BCL2L14 + Q9BZR8 + Apoptosis facilitator Bcl-2-like 14 protein + 12p13-p12 + MCSTSGCDLEEIPLDDDDLNTIEFKILAYY + http://www.pir.uniprot.org/cgi-bin/upEntry?id=B2L14_HUMAN + + apoptosis + 1 + 0.2 + lymphoma + + + + intracellular organelle + + + + mixed + 1 + 99 + + + irgendwo + + 35.9296730123456789 + -78.9482370123456789 + 0 + + + + bar + + node a + 0.2 + + 12 + 14 + 16 + + a id + + 123 + CAEEL + C elegans + elegant nematode worm + species + http://www.wormbase.org/ + + + CAEEL_XYZ + + + + node b + + 1 + 80 + + + + c + + + d + e + f + + + a + b + + + + node ba + + Africa + + + + node bb + + + A + B + C + + + D + + + X + M + + + + + node bc + + bc seq + + A + B + C + D + + + + + + + diff --git a/forester/test_data/phyloxml_test_t1.xml b/forester/test_data/phyloxml_test_t1.xml new file mode 100644 index 0000000..c6b9e8c --- /dev/null +++ b/forester/test_data/phyloxml_test_t1.xml @@ -0,0 +1,210 @@ + + + + t1 + + + + t2 + + root node + + node a + + some parasite + + + the host + + + actgtgggggtggggaggcggaggggtgtggtacactgactactgactgactga_ctgacgatcatatgac + + + + ctgtgatgcatgcatgcatgcatgcatcgatcgccggcatgcatcgatatctacgctgactgactagctactagtcacacgtgacgcgcgcatgc*** + + + + + node b + 2 + + + + + t3 + 1-1 + test phylogeny + 0.1 + + root node + 90 + 1e-3 + 2 + 10 + + 2 + 22 + 33 + + root id + + 1 + ECDYS + ecdysozoa + molting animals + phylum + http://www.ecdysozoa.org/ + + + BCL2L14 + Q9BZR8 + Apoptosis facilitator Bcl-2-like 14 protein + 12p13-p12 + MCSTSGCDLEEIPLDDDDLNTIEFKILAYY + http://www.pir.uniprot.org/cgi-bin/upEntry?id=B2L14_HUMAN + + intracellular organelle + + + + apoptosis + 1 + 0.2 + lymphoma + + + + mixed + 1 + 99 + + + irgendwo + + 35.9296730123456789 + -78.9482370123456789 + 0 + + + + + Aguinaldo, A. M. A.; J. M. Turbeville, L. S. Linford, M. C. Rivera, J. R. Garey, R. A. Raff, & J. A. Lake (1997). "Evidence for a clade of nematodes, arthropods and other moulting animals". Nature 387 (6632): 489–493. + + + bar + + node a + 0.2 + + 12 + 14 + 16 + + a id + + 123 + CAEEL + C elegans + elegant nematode worm + species + http://www.wormbase.org/ + + + CAEEL_XYZ + + + + node b + + 1 + 80 + + + + c + + + d + e + f + + + a + b + + + + node ba + + Africa + + + Silurian + 435 + 416 + 443.7 + + + + node bb + + 704294 + NEMVE + Nematostella vectensis + Stephenson, 1935 + starlet sea anemone + Nematostella vectensis Stephenson1935 + See + Anemone + + + species + http://www.eol.org/pages/704294 + + + + A + B + C + + + D + + + X + M + + + + Triassic + + + + node bc + + bc seq + + A + B + C + D + + + + 433 + + + + + + + t4 + + + + + + diff --git a/forester/test_data/phyloxml_test_t2.xml b/forester/test_data/phyloxml_test_t2.xml new file mode 100644 index 0000000..90bc285 --- /dev/null +++ b/forester/test_data/phyloxml_test_t2.xml @@ -0,0 +1,48 @@ + + + + + + a + + a1 + + a11 + + + a12 + + + + a2 + + a21 + + + a22 + + + + + b + + + c + + c1 + + c2 + + c31 + + + c32 + + + + + + + diff --git a/forester/test_data/phyloxml_test_t3.xml b/forester/test_data/phyloxml_test_t3.xml new file mode 100644 index 0000000..d68e3ee --- /dev/null +++ b/forester/test_data/phyloxml_test_t3.xml @@ -0,0 +1,54 @@ + + + foo bar + + + 2008-12-12T12:12:12 + + a + + 0.2 + 0.99 + 0.89 + c + + bax + acgtddd + + + fusion + + foo bar + + + + 223 + 0.1 + b + + qwerty + + + qw-_| + bcl2 + + + + + 0.99 + + + big + + + 12 + + foobar + + + tip name + + + diff --git a/forester/test_data/phyloxml_test_t4.xml b/forester/test_data/phyloxml_test_t4.xml new file mode 100644 index 0000000..7962b84 --- /dev/null +++ b/forester/test_data/phyloxml_test_t4.xml @@ -0,0 +1,50 @@ + + + + atcgt + atctt + + + other tree 0 + + + tree 4 + + root node + + node a + + + node b + + node b1 + + b1 species + some species wrong + quite unneededly, this is called at "tip"! + + + b1 gene + b2 gene wrong + + + + node b2 + + + other clade + + + + + + other tree + + + atcgt + atctt + + + diff --git a/forester/test_data/quotes.nhx b/forester/test_data/quotes.nhx new file mode 100644 index 0000000..d735318 --- /dev/null +++ b/forester/test_data/quotes.nhx @@ -0,0 +1,12 @@ +(((A_A:-0.1,B_B:0.12):0.123,C_C:0.1234):0.666,D_D:0.6666666666,E_E:0.9); +((((DEBIL_ECOLI:-0.1,DEBIL_BACSU/1-33:0):0.1,B:0.1):-0.1,C:0.1),D:0.1,E:0.1); +((A:0.1,B:0.1):0.1[&&NHX:B=1.23456789],(C:0.1,D:0.1)); +((A:0.1,B:0.1)1.23456789:0.1,(C:0.1,D:0.1)90:0.1); +(("a name in dou +ble quotes from tree ((a,b),c)"[comment: ignore(,b,,)"]:0.1[comment],"charles darwin 'origin of species'"[&&NHX:S="hsapiens"]:0.1)[13]:0.1,(should be together ' single quotes':0.1, +"'single quotes' inside +double quotes":0.1, +'"double quotes" inside +single quotes':0.1, +no quotes:0.1, +"A ( B C '"[comment))))]:0.1)90[another point less "comment"]:0.1); \ No newline at end of file diff --git a/forester/test_data/special_characters.xml b/forester/test_data/special_characters.xml new file mode 100644 index 0000000..74e825c --- /dev/null +++ b/forester/test_data/special_characters.xml @@ -0,0 +1,31 @@ + + + + + + + + + first + + + <> + + + "<a'b&c'd">" + + + + '''" + + + + """ + + + + dick & doof + + + + diff --git a/forester/test_data/species_tree_1.xml b/forester/test_data/species_tree_1.xml new file mode 100644 index 0000000..0b5c7d7 --- /dev/null +++ b/forester/test_data/species_tree_1.xml @@ -0,0 +1,117 @@ + + + + + + + + + + + + + + + + + + MOUSE + + + + + RAT + + + + + + HUMAN + + + + + + CHICK + + + + + + XENLA + + + + + + CIOIN + + + + + + BRAFL + + + + + + STRPU + + + + + + + + DROME + + + + + CAEEL + + + + + + LOTGI + + + + + + + + NEMVE + + + + + BEROV + + + + + + + TRIAD + + + + + + MONBE + + + + + + YEAST + + + + + diff --git a/forester/test_data/species_tree_1_unresolved.xml b/forester/test_data/species_tree_1_unresolved.xml new file mode 100644 index 0000000..5da2474 --- /dev/null +++ b/forester/test_data/species_tree_1_unresolved.xml @@ -0,0 +1,107 @@ + + + + + + + + + + + + + + + MOUSE + + + + + RAT + + + + + HUMAN + + + + + + CHICK + + + + + + XENLA + + + + + + CIOIN + + + + + BRAFL + + + + + + STRPU + + + + + + + DROME + + + + + CAEEL + + + + + LOTGI + + + + + + + NEMVE + + + + + BEROV + + + + + TRIAD + + + + + + MONBE + + + + + + YEAST + + + + + diff --git a/forester/test_data/tol_16299.tol b/forester/test_data/tol_16299.tol new file mode 100644 index 0000000..84a7b4d --- /dev/null +++ b/forester/test_data/tol_16299.tol @@ -0,0 +1,259 @@ + + + + + + + + + + null + + + + + + + + + + + + + + + null + + + + + + + + + + + + + + + null + + + + + + + + null + + + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + + + + + + + + null + + + + + + + + + + + + + + + + + + + + + + + + + null + + + + + + + + + + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + + + + + + + + 0 + + + + + + + + + + + + + + + 0 + + + + + + + + 0 + + + + + + + + 0 + + + + + + + + 0 + + + + + + + + + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + + + diff --git a/forester/test_data/tol_2.tol b/forester/test_data/tol_2.tol new file mode 100644 index 0000000..61e38ce --- /dev/null +++ b/forester/test_data/tol_2.tol @@ -0,0 +1,6156 @@ + + + + + + + + + + 0 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 0 + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + + + 0 + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + + + 0 + + + + + + + + null + + + + + + + + null + + + + + + + + + + null + + + + + + + + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + null + + + + + + + + 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